Ontology about C. elegans and other nematode phenotypes C elegans Phenotype Ontology C_elegans_phenotype_ontology chris-grove 2023-03-02 definition WB phenotype slim subset_property has_alternative_id has_broad_synonym database_cross_reference has_exact_synonym has_narrow_synonym has_obo_format_version has_obo_namespace has_related_synonym in_subset WBPhenotype:0000311 Variations in the frequencies of translocations, inversions, deletions, or gene amplifications and variations in chromosome fusion events and or chromosomal loss compared to control. C_elegans_phenotype_ontology WBPhenotype:0000000 chromosome instability Variations in the frequencies of translocations, inversions, deletions, or gene amplifications and variations in chromosome fusion events and or chromosomal loss compared to control. WB:WBPerson557 WB:WBPerson712 Animals exhibit variations in body posture compared to control animals. For example, in C. elegans characteristic sinusoidal body posture is altered. body posture abnormal C_elegans_phenotype_ontology WBPhenotype:0000001 body posture variant Animals exhibit variations in body posture compared to control animals. For example, in C. elegans characteristic sinusoidal body posture is altered. WB:WBPerson557 WB:cab The animal moves or rests with uncharacteristic loss of smooth sinusoidal motion or body posture. Movement is often characterized by severe bending motions, more sharply angled and/or much deeper than stereotypical sinusoidal body bends of the control animals. C_elegans_phenotype_ontology WBPhenotype:0000002 kinker The animal moves or rests with uncharacteristic loss of smooth sinusoidal motion or body posture. Movement is often characterized by severe bending motions, more sharply angled and/or much deeper than stereotypical sinusoidal body bends of the control animals. WB:WBPerson2021 WB:WBPerson557 WB:WBPerson712 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000003 obsolete flattened locomotion path true Eggs are laid under conditions where egg laying is normally inhibited. Egl c C_elegans_phenotype_ontology WBPhenotype:0000004 Liquid M9. constitutive egg laying Eggs are laid under conditions where egg laying is normally inhibited. WB:cab Eggs are laid at an earlier stage of development, eggs are laid in the presence of inhibitors of egg laying, or the inactive phase of the egg-laying cycle is significantly shorter when compared to control. C_elegans_phenotype_ontology WBPhenotype:0000005 hyperactive egg laying Eggs are laid at an earlier stage of development, eggs are laid in the presence of inhibitors of egg laying, or the inactive phase of the egg-laying cycle is significantly shorter when compared to control. WB:cab Eggs are not laid, laid at a slower rate or eggs are laid at a later stage of development compared to control. Egl d C_elegans_phenotype_ontology WBPhenotype:0000006 egg laying defective Eggs are not laid, laid at a slower rate or eggs are laid at a later stage of development compared to control. WB:WBPaper00004402 WB:WBPaper00004651 WB:WBPaper00005654 WB:WBPaper00006395 WB:WBPaper00024497 WB:WBPaper00025054 WB:cab A worm carcass is formed with retained eggs that hatch inside. Bag C_elegans_phenotype_ontology WBPhenotype:0000007 bag of worms A worm carcass is formed with retained eggs that hatch inside. WB:cab Animals respond to anesthetic at a lower concentration or a shorter exposure compared to control animals. anaesthetic hypersensitive C_elegans_phenotype_ontology WBPhenotype:0000008 anesthetic hypersensitive Animals respond to anesthetic at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 Animals fail to respond to the concentration of anesthetic that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. anaesthetic resistant C_elegans_phenotype_ontology WBPhenotype:0000009 anesthetic resistant Animals fail to respond to the concentration of anesthetic that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 Animals respond to a specific drug at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000010 drug hypersensitive Animals respond to a specific drug at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 Animals fail to respond to the concentration of a drug that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. Animals are not affected by exposure to the drug. C_elegans_phenotype_ontology WBPhenotype:0000011 drug resistant Animals fail to respond to the concentration of a drug that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. Animals are not affected by exposure to the drug. WB:WBPerson557 Formation of dauer larvae under conditions that do not favor dauer formation. Daf c C_elegans_phenotype_ontology WBPhenotype:0000012 dauer constitutive Formation of dauer larvae under conditions that do not favor dauer formation. WB:kmva Failure to form dauer larvae under dauer-inducing conditions. Daf d C_elegans_phenotype_ontology WBPhenotype:0000013 dauer defective Failure to form dauer larvae under dauer-inducing conditions. WB:kmva Variations in the structure, organization or path of axon tracts that grow circumferentially around the animal in a single, directed trajectory to bridge the ventral and dorsal cords, compared to control animals. cord commissures abnormal C_elegans_phenotype_ontology WBPhenotype:0000014 cord commissures variant Variations in the structure, organization or path of axon tracts that grow circumferentially around the animal in a single, directed trajectory to bridge the ventral and dorsal cords, compared to control animals. WB:WBPaper00001499 WB:WBPaper00029065 WB:WBPerson712 Variations in the movement towards typically attractive chemicals. C_elegans_phenotype_ontology WBPhenotype:0000015 positive chemotaxis defective Variations in the movement towards typically attractive chemicals. WB:cab Animals respond to aldicarb at a lower concentration or a shorter exposure compared to control animals. Hic C_elegans_phenotype_ontology WBPhenotype:0000016 aldicarb hypersensitive Animals respond to aldicarb at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 Animals fail to respond to the concentration of aldicarb that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. Ald R Ric C_elegans_phenotype_ontology WBPhenotype:0000017 aldicarb resistant Animals fail to respond to the concentration of aldicarb that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 The contraction and relaxation movements of the pharynx occur at a greater frequency compared to that observed for control animals. C_elegans_phenotype_ontology WBPhenotype:0000018 pharyngeal pumping increased The contraction and relaxation movements of the pharynx occur at a greater frequency compared to that observed for control animals. WB:WBPerson712 Pharyngeal pumping motion occurs at a slower rate than control animals. C_elegans_phenotype_ontology WBPhenotype:0000019 pharyngeal pumping reduced Pharyngeal pumping motion occurs at a slower rate than control animals. WB:WBPaper00001709 Pharyngeal pumping motion occurs at intervals that vary from control animals. C_elegans_phenotype_ontology WBPhenotype:0000020 pharyngeal pumping irregular Pharyngeal pumping motion occurs at intervals that vary from control animals. WB:WBPaper00001709 Squat animals are dumpy as homozygotes, but roll as heterozygotes. Sqt C_elegans_phenotype_ontology WBPhenotype:0000021 squat Squat animals are dumpy as homozygotes, but roll as heterozygotes. WB:WBPaper00000906 Animals are longer than control animals at the same developmental stage. Lon C_elegans_phenotype_ontology WBPhenotype:0000022 long Animals are longer than control animals at the same developmental stage. WB:cab WB:cgc31 Animals respond to serotonin at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000023 serotonin hypersensitive Animals respond to serotonin at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 Animals fail to respond to the concentration of serotonin that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000024 serotonin resistant Animals fail to respond to the concentration of serotonin that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 Fluid-filled blisters appear on the cuticle. Bli C_elegans_phenotype_ontology WBPhenotype:0000025 blistered Fluid-filled blisters appear on the cuticle. WB:WBPaper00004402 WB:WBPaper00005654 WB:WBPaper00006395 WB:WBPaper00024497 WB:cab WB:cgc31 Animals are unable to take up or store lipids. In C. elegans, this defect results in pale, skinny and arrested larva. Lpd C_elegans_phenotype_ontology fat depleted WBPhenotype:0000026 lipid depleted Animals are unable to take up or store lipids. In C. elegans, this defect results in pale, skinny and arrested larva. GO:0006629 WB:WBPaper00005707 WB:WBPerson712 Variations in the chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances compared to control. organism metabolism processing abnormal C_elegans_phenotype_ontology WBPhenotype:0000027 organism metabolism processing variant Variations in the chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances compared to control. GO:0008152 WB:WBPerson2021 WB:WBPerson557 Variations in the processes involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules compared to control. RNA processing abnormal C_elegans_phenotype_ontology WBPhenotype:0000028 RNA processing variant Variations in the processes involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules compared to control. GO:0006396 WB:WBPerson2021 Animals are defective for RNAi introduced by environmental means such as in the cases of RNAi triggered by soaking or feeding. systemic RNAi abnormal C_elegans_phenotype_ontology Environmental RNAi defective WBPhenotype:0000029 systemic RNAi variant Animals are defective for RNAi introduced by environmental means such as in the cases of RNAi triggered by soaking or feeding. WB:WBPaper00029209 WB:WBPaper00030758 WB:WBPerson712 Variations in the processes that regulate the change (increase) in size or mass of an integrated living unit (a cell, tissue, organ or organism) compared to control animals. growth abnormal C_elegans_phenotype_ontology WBPhenotype:0000030 growth variant Variations in the processes that regulate the change (increase) in size or mass of an integrated living unit (a cell, tissue, organ or organism) compared to control animals. GO:0040007 WB:WBPerson2021 Any variation that causes a reduction in growth rate compared to control. Gro C_elegans_phenotype_ontology WBPhenotype:0000031 slow growth Any variation that causes a reduction in growth rate compared to control. WB:WBPaper00004402 WB:WBPaper00004403 WB:WBPaper00004651 WB:WBPaper00004769 WB:WBPaper00005654 WB:WBPaper00006395 WB:WBPaper00024497 WB:WBPerson557 WB:cab Animals exhibit some combination of abnormal features relating to size, movement, body integrity, pigmentation, viability, fertility etc. Sck C_elegans_phenotype_ontology WBPhenotype:0000032 sick Animals exhibit some combination of abnormal features relating to size, movement, body integrity, pigmentation, viability, fertility etc. WB:WBPaper00000179 WB:WBPaper00000565 WB:WBPerson712 The timing of specific developmental events in some tissues is altered relative to the timing of events in other tissues. WBPhenotype:0000437 heterochronic defect developmental timing abnormal C_elegans_phenotype_ontology WBPhenotype:0000033 Possible XP GO:0040034. developmental timing variant The timing of specific developmental events in some tissues is altered relative to the timing of events in other tissues. WB:cab pmid:6494891 Contents or structures of an embryonic cell are not restricted/localized to the same positions (or poles) compared with control animals. embryonic polarity abnormal C_elegans_phenotype_ontology WBPhenotype:0000034 embryonic polarity variant Contents or structures of an embryonic cell are not restricted/localized to the same positions (or poles) compared with control animals. WB:WBPaper00005079 WB:WBPerson2021 WB:WBPerson712 Any variation in the overall structure or appearance of the animal as it progresses from hatching to adult compared to control animals. larval body morphology abnormal C_elegans_phenotype_ontology larval morphology abnormal WBPhenotype:0000035 larval body morphology variant Any variation in the overall structure or appearance of the animal as it progresses from hatching to adult compared to control animals. WB:WBPerson2021 WB:WBPerson557 Any variation in the overall structure or appearance of the animal after it has completed progression through the larval stages compared to control animals. adult body morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000036 adult body morphology variant Any variation in the overall structure or appearance of the animal after it has completed progression through the larval stages compared to control animals. WB:WBPerson2021 WB:WBPerson557 Any variation in the overall structure or appearance of fertilized oocytes that are laid compared to those laid by control animals. egg morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000037 egg morphology variant Any variation in the overall structure or appearance of fertilized oocytes that are laid compared to those laid by control animals. WB:WBPaper00001075 WB:WBPerson2021 The animal is ruptured at the vulva and displays an extrusion of internal organs at the site of rupture. Rup C_elegans_phenotype_ontology burst vulva gonad eversion gonad exploded through vulva rupture through vulva WBPhenotype:0000038 exploded through vulva The animal is ruptured at the vulva and displays an extrusion of internal organs at the site of rupture. WB:WBPaper00027633 WB:WBPaper00031094 WB:WBPerson712 Adult life span is either longer or shorter than typical of control animals. Age life span abnormal life span variant C_elegans_phenotype_ontology longevity abnormal WBPhenotype:0000039 life span phenotype Adult life span is either longer or shorter than typical of control animals. GO:0008340 WB:WBPaper00005863 WB:WBPaper00026717 WB:WBPerson557 WB:cab Embryos fail to divide and arrest as one-cell embryos. Emb Ocs C_elegans_phenotype_ontology catastrophic one cell arrest WBPhenotype:0000040 one cell arrest early emb Embryos fail to divide and arrest as one-cell embryos. WB:cab WB:cgc5599 catastrophic one cell arrest WB:cgc5599 Any variation in the process involved in the maintenance of an internal equilibrium of water within an organism, compared to control. osmotic integrity abnormal C_elegans_phenotype_ontology osmoregulation variant WBPhenotype:0000041 osmotic integrity variant Any variation in the process involved in the maintenance of an internal equilibrium of water within an organism, compared to control. GO:0030104 WB:WBPerson2021 The progression through stages between fertilization to hatching are temporally retarded. Sle C_elegans_phenotype_ontology WBPhenotype:0000042 slow embryonic development The progression through stages between fertilization to hatching are temporally retarded. WB:WBPerson712 Variations in the progression time of an animal from pronuclei meeting to adulthood compared to control animals. general pace of development abnormal C_elegans_phenotype_ontology WBPhenotype:0000043 general pace of development variant Variations in the progression time of an animal from pronuclei meeting to adulthood compared to control animals. WB:WBPerson2021 WB:WBPerson557 Egg is smaller or larger compared to eggs of control animals. Emb C_elegans_phenotype_ontology WBPhenotype:0000044 egg size defective early emb Egg is smaller or larger compared to eggs of control animals. WB:cab WB:cgc7141 The developmental progression of an animal after the embryonic stage, over time, from its formation to its mature structure is delayed compared to control. C_elegans_phenotype_ontology WBPhenotype:0000045 developmental delay postembryonic The developmental progression of an animal after the embryonic stage, over time, from its formation to its mature structure is delayed compared to control. WB:WBPaper00025054 WB:cab More than five minutes between AB and P1 divisions. Emb pace of P lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000046 pace of P lineage defective early emb More than five minutes between AB and P1 divisions. WB:cab WB:cgc7141 Variations in the process by which the germ layers become positioned in an embryo compared to control animals. Gastrulation involves the proper ingression of small groups of cells at various times into the blastocoel space. gastrulation abnormal C_elegans_phenotype_ontology WBPhenotype:0000047 gastrulation variant Variations in the process by which the germ layers become positioned in an embryo compared to control animals. Gastrulation involves the proper ingression of small groups of cells at various times into the blastocoel space. WB:WBPaper00027251 WB:WBPerson2021 Variations in the ability of an animal to emerge from the protective egg shell compared to control animals. hatching abnormal C_elegans_phenotype_ontology WBPhenotype:0000048 hatching variant Variations in the ability of an animal to emerge from the protective egg shell compared to control animals. GO:0035188 WB:WBPerson2021 Any variation in the progression of an animal over time, from hatching to adulthood, compared to control. postembryonic development abnormal C_elegans_phenotype_ontology WBPhenotype:0000049 postembryonic development variant Any variation in the progression of an animal over time, from hatching to adulthood, compared to control. WB:WBPerson2021 Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die. Emb C_elegans_phenotype_ontology egg lethal embryonic death inviable zygote WBPhenotype:0000050 embryonic lethal Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die. WB:WBPaper00000179 WB:WBPaper00004403 WB:WBPaper00004540 WB:WBPaper00004651 WB:WBPaper00004769 WB:WBPaper00005654 WB:WBPaper00024497 WB:WBPaper00024925 WB:WBPaper00025054 WB:cab The developmental program does not continue past embryogenesis; stage of arrest is not consistent from animal to animal. Emb Etv C_elegans_phenotype_ontology WBPhenotype:0000051 embryonic terminal arrest variable emb The developmental program does not continue past embryogenesis; stage of arrest is not consistent from animal to animal. GO:0009790 WB:WBPaper00004811 WB:WBPaper00024944 WB:WBPerson712 Lethality caused by the perturbation of maternal gene products that are contributed to oogenesis and are required during embryogenesis. Emb Mel C_elegans_phenotype_ontology WBPhenotype:0000052 maternal effect lethal emb Lethality caused by the perturbation of maternal gene products that are contributed to oogenesis and are required during embryogenesis. WB:WBPaper00001109 WB:WBPerson2021 Movement and elongation ceases at the two-fold stage. The myofilament lattice in body wall muscle cells is variant. However, development in embryos continues. Embryos hatch as inviable larvae. Pat C_elegans_phenotype_ontology active elongation arrest two fold arrest WBPhenotype:0000053 paralyzed arrested elongation two fold Movement and elongation ceases at the two-fold stage. The myofilament lattice in body wall muscle cells is variant. However, development in embryos continues. Embryos hatch as inviable larvae. WB:cab WB:cgc1894 The animal dies at any time between hatching and onset to adulthood. Let Lvl C_elegans_phenotype_ontology larval death WBPhenotype:0000054 larval lethal The animal dies at any time between hatching and onset to adulthood. GO:0002119 WB:WBPerson712 Larvae arrest during early larval development. In C. elegans, this occurs during the L1 or L2 stages of larval development. C_elegans_phenotype_ontology WBPhenotype:0000055 early larval arrest Larvae arrest during early larval development. In C. elegans, this occurs during the L1 or L2 stages of larval development. WB:cab Larvae arrest during late larval development. In C. elegans, larval arrest occurs during the L3 or L4 stages of larval development. C_elegans_phenotype_ontology WBPhenotype:0000056 late larval arrest Larvae arrest during late larval development. In C. elegans, larval arrest occurs during the L3 or L4 stages of larval development. WB:cab Animals die during early larval development. In C.elegans, this occurs during the L1- L2 larval stages of the life cycle. Let Lvl C_elegans_phenotype_ontology WBPhenotype:0000057 early larval lethal Animals die during early larval development. In C.elegans, this occurs during the L1- L2 larval stages of the life cycle. WB:WBPerson2021 Animals die during late larval development. In C. elegans, this occurs during the L3- L4 larval stages of the life cycle. Let Lvl C_elegans_phenotype_ontology WBPhenotype:0000058 late larval lethal Animals die during late larval development. In C. elegans, this occurs during the L3- L4 larval stages of the life cycle. WB:WBPerson2021 The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage. Lva C_elegans_phenotype_ontology WBPhenotype:0000059 larval arrest The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage. WB:WBPaper00002958 WB:WBPerson2021 Premature lethality during the adult stage. When applied to large-scale RNAi screens in C. elegans, this phenotype is present in at least 10% of analyzed worms, or at least 30% in the case of rrf-3 perturbed background. Adl Let C_elegans_phenotype_ontology WBPhenotype:0000060 adult lethal Premature lethality during the adult stage. When applied to large-scale RNAi screens in C. elegans, this phenotype is present in at least 10% of analyzed worms, or at least 30% in the case of rrf-3 perturbed background. WB:WBPaper00004402 WB:WBPaper00005654 WB:WBPaper00006395 WB:cab Adl WB:WBPaper00004402 WB:WBPaper00005654 The duration of viability in the adult phase of the life-cycle surpasses that of control animals. Age C_elegans_phenotype_ontology life span increased longevity increased WBPhenotype:0000061 extended life span The duration of viability in the adult phase of the life-cycle surpasses that of control animals. GO:0008340 WB:WBPerson712 Animals die prematurely at any stage of the life cycle. Let C_elegans_phenotype_ontology WBPhenotype:0000062 lethal Animals die prematurely at any stage of the life cycle. WB:WBPaper00001109 WB:WBPerson2021 Variations that cause developmental progression to cease at different stages of the lifecycle. Var C_elegans_phenotype_ontology WBPhenotype:0000063 terminal arrest variable Variations that cause developmental progression to cease at different stages of the lifecycle. WB:WBPerson2021 WB:WBPerson557 Animals die prematurely at any stage of the life cycle in a sex dependent manner. C_elegans_phenotype_ontology Let WBPhenotype:0000064 sexually dimorphic lethality Animals die prematurely at any stage of the life cycle in a sex dependent manner. WB:WBPerson2021 WB:WBPerson557 XO-bearing individuals die preferentially over other animals in the population. In C.elegans, X0 animals die preferentially over XX animals. Let C_elegans_phenotype_ontology male specific lethality WBPhenotype:0000065 X0 lethal XO-bearing individuals die preferentially over other animals in the population. In C.elegans, X0 animals die preferentially over XX animals. WB:WBPerson363 WB:WBPerson712 XX-bearing individuals die preferentially over other animals in the population. In C.elegans, XX animals die preferentially over X0 animals. C_elegans_phenotype_ontology hermaphrodite specific lethality WBPhenotype:0000066 XX lethal XX-bearing individuals die preferentially over other animals in the population. In C.elegans, XX animals die preferentially over X0 animals. WB:WBPerson363 WB:WBPerson712 Animals exhibit variations in response to stress stimuli compared to control animals. organism stress response abnormal C_elegans_phenotype_ontology WBPhenotype:0000067 organism stress response variant Animals exhibit variations in response to stress stimuli compared to control animals. GO:0006950 WB:WBPerson712 Any variation in the state or activity of a cell (in terms of secretion, enzyme production, gene expression, etc.) in response to high levels of reactive oxygen species, compared to control. oxidative stress response abnormal C_elegans_phenotype_ontology WBPhenotype:0000068 cellular oxidative stress response variant Any variation in the state or activity of a cell (in terms of secretion, enzyme production, gene expression, etc.) in response to high levels of reactive oxygen species, compared to control. GO:0034599 WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of the progeny of an animal at any time from its fertilization to adulthood compared to control. progeny abnormal C_elegans_phenotype_ontology WBPhenotype:0000069 progeny variant Any variation in the progression of the progeny of an animal at any time from its fertilization to adulthood compared to control. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the structure or organization of the somatic reproductive components of the posterior segment of the male from that observed in control males. In C. elegans, this region of the male includes the terminal canals of the reproductive tract, the digestive tract, and spicule channels along with the male specific sensilla (ray, post-cloacal, hook and spicule) and extends to the tip of the acellular fan. Mab male tail morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000070 male tail morphology variant Animals exhibit variations in the structure or organization of the somatic reproductive components of the posterior segment of the male from that observed in control males. In C. elegans, this region of the male includes the terminal canals of the reproductive tract, the digestive tract, and spicule channels along with the male specific sensilla (ray, post-cloacal, hook and spicule) and extends to the tip of the acellular fan. WB:WBPaper00027278 WB:WBPerson712 Animals exhibit variations in the form, structure or composition of any portion of their anterior end (which typically includes the anterior sensilla, pharynx and all muscles that are innervated by the nerve ring) compared to control. head morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000071 head morphology variant Animals exhibit variations in the form, structure or composition of any portion of their anterior end (which typically includes the anterior sensilla, pharynx and all muscles that are innervated by the nerve ring) compared to control. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the form, structure or composition of any portion of their anatomy between the head and the tail compared to control animals. body morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000072 body morphology variant Animals exhibit variations in the form, structure or composition of any portion of their anatomy between the head and the tail compared to control animals. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the form, structure or composition of any portion of the most posterior region of the body compared to control. The anterior bound of the tail is not well defined though it might range from the position of the post-deirids to the opening of the anus (Wormatlas). tail morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000073 tail morphology variant Animals exhibit variations in the form, structure or composition of any portion of the most posterior region of the body compared to control. The anterior bound of the tail is not well defined though it might range from the position of the post-deirids to the opening of the anus (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the set of interactions occurring between a group of genes who depend on each other's individual functions in order to make the aggregate function of the network available to the cell, compared to control. genetic pathway abnormal C_elegans_phenotype_ontology WBPhenotype:0000074 genetic pathway variant Any variation in the set of interactions occurring between a group of genes who depend on each other's individual functions in order to make the aggregate function of the network available to the cell, compared to control. WB:WBPerson2021 WB:WBPerson557 Any variation in the attachment of the rigid external coating (which is secreted by the hypodermis, seam and some interfacial epithelial cells) to the outer body of an animal compared to control (Wormatlas). cuticle attachment abnormal C_elegans_phenotype_ontology WBPhenotype:0000075 cuticle attachment variant Any variation in the attachment of the rigid external coating (which is secreted by the hypodermis, seam and some interfacial epithelial cells) to the outer body of an animal compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Variations in the adhesion of the layer of cells that cover the external surface of an organism which serves to protect the animal from external environment compared to control. epithelial attachment abnormal C_elegans_phenotype_ontology hypodermal attachment abnormal WBPhenotype:0000076 epithelial attachment variant Variations in the adhesion of the layer of cells that cover the external surface of an organism which serves to protect the animal from external environment compared to control. WB:WBPerson2021 WB:WBPerson557 Animals exhibit defects in the process of shedding, part or all of its cuticle, during cuticle replacement. cuticle shedding abnormal C_elegans_phenotype_ontology WBPhenotype:0000077 cuticle shedding defect Animals exhibit defects in the process of shedding, part or all of its cuticle, during cuticle replacement. GO:0018996 The hypodermal cells, which lie along the lateral body wall to form longitudinal stripes of epithelial cells underlying the alae, are misplaced such that they are stacked along the dorsal-ventral axis rather than forming a continuous row of adjacent cells . C_elegans_phenotype_ontology WBPhenotype:0000078 seam cells stacked The hypodermal cells, which lie along the lateral body wall to form longitudinal stripes of epithelial cells underlying the alae, are misplaced such that they are stacked along the dorsal-ventral axis rather than forming a continuous row of adjacent cells . WB:WBPaper00003081 The small linear ridges running along the lateral lines of the cuticle of adults are branched as opposed to having an unbiforcated arrangement, lengthwise along the body (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000079 branched adult alae The small linear ridges running along the lateral lines of the cuticle of adults are branched as opposed to having an unbiforcated arrangement, lengthwise along the body (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Animals lack the anterior portion of the pharynx. Aph C_elegans_phenotype_ontology WBPhenotype:0000080 no anterior pharynx Animals lack the anterior portion of the pharynx. WB:WBPerson2021 WB:WBPerson557 The developmental program of the animals does not continue past the first larval stage (L1). C_elegans_phenotype_ontology WBPhenotype:0000081 L1 arrest The developmental program of the animals does not continue past the first larval stage (L1). WB:WBPaper00003179 WB:WBPerson2021 The developmental program of the animals does not continue past the second larval stage (L2). C_elegans_phenotype_ontology WBPhenotype:0000082 L2 arrest The developmental program of the animals does not continue past the second larval stage (L2). WB:WBPaper00003179 WB:WBPerson2021 The developmental program of the animals does not continue past the third larval stage (L3). C_elegans_phenotype_ontology WBPhenotype:0000083 L3 arrest The developmental program of the animals does not continue past the third larval stage (L3). WB:WBPaper00004813 WB:WBPerson2021 The developmental program of the animals does not continue past the fourth larval stage (L4). C_elegans_phenotype_ontology WBPhenotype:0000084 L4 arrest The developmental program of the animals does not continue past the fourth larval stage (L4). WB:WBPaper00003179 WB:WBPerson2021 The intestinal lumen is expanded and can often be shown to be filled with bacteria. This swelling is distinct from distension of the entire intestine (intestinal edema). C_elegans_phenotype_ontology WBPhenotype:0000085 swollen intestinal lumen The intestinal lumen is expanded and can often be shown to be filled with bacteria. This swelling is distinct from distension of the entire intestine (intestinal edema). WB:WBPaper00026641 WB:WBPerson712 Intestine is shrunken and may appear constricted. C_elegans_phenotype_ontology WBPhenotype:0000086 shrunken intestine Intestine is shrunken and may appear constricted. WB:WBPaper00005941 Any variation in the progression of a body wall muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. body wall cell development abnormal C_elegans_phenotype_ontology body wall muscle cell development abnormal WBPhenotype:0000087 body wall cell development variant Any variation in the progression of a body wall muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. WB:WBPerson2021 The arrangement of the principal muscle cell type whose contractile activity generates body motion in the nematode differs from that observed in control animals. In C. elegans they consist of 95 unfused cells in the adult organized into four muscle quadrants. Their sarcomeres are obliquely striated and lie lengthwise along the body wall (Wormatlas). C_elegans_phenotype_ontology body wall muscle displaced WBPhenotype:0000088 body muscle displaced The arrangement of the principal muscle cell type whose contractile activity generates body motion in the nematode differs from that observed in control animals. In C. elegans they consist of 95 unfused cells in the adult organized into four muscle quadrants. Their sarcomeres are obliquely striated and lie lengthwise along the body wall (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Animals fail to respond to the concentration of alpha amanitin that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000089 alpha amanitin resistant Animals fail to respond to the concentration of alpha amanitin that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 Animals are deficient in the adhesion of the cuticle to the epidermal surface of the animal. C_elegans_phenotype_ontology hypodermis detached from cuticle WBPhenotype:0000090 epidermis cuticle detached Animals are deficient in the adhesion of the cuticle to the epidermal surface of the animal. WB:WBPerson2021 WB:WBPerson557 The cell(s) whose principal function is to provide contractile forces, is separated from the adjacent epidermis. C_elegans_phenotype_ontology hypodermis detached from muscle WBPhenotype:0000091 epidermis muscle detached The cell(s) whose principal function is to provide contractile forces, is separated from the adjacent epidermis. WB:WBPerson2021 WB:WBPerson557 Any variation in the processes that govern the expansion of intestinal cell populations compared to control. intestinal cell proliferation abnormal C_elegans_phenotype_ontology WBPhenotype:0000092 intestinal cell proliferation variant Any variation in the processes that govern the expansion of intestinal cell populations compared to control. WB:WBPerson2021 The descendants of a particular precursor cell exhibit variations in developmental programs compared to their counterparts in control animals. Lin lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000093 lineage variant The descendants of a particular precursor cell exhibit variations in developmental programs compared to their counterparts in control animals. WB:WBPerson2021 Any variation in the progression of the caudal opening of the rectum in the tail over time compared to control (Wormatlas). anus development abnormal C_elegans_phenotype_ontology WBPhenotype:0000094 anus development variant Any variation in the progression of the caudal opening of the rectum in the tail over time compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 The descendants of the M precursor cell exhibit variations in developmental programs compared to their counterparts in control animals. In C. elegans the M lineage is a postembryonic mesodermal lineage. M lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000095 M lineage variant The descendants of the M precursor cell exhibit variations in developmental programs compared to their counterparts in control animals. In C. elegans the M lineage is a postembryonic mesodermal lineage. WB:WBPerson2021 Variations in the progression of the epithelial chamber that links the genital and alimentary tracts to the exterior via the anus (cloacal opening) over time compared to control (Wormatlas). cloacal development abnormal C_elegans_phenotype_ontology WBPhenotype:0000096 cloacal development variant Variations in the progression of the epithelial chamber that links the genital and alimentary tracts to the exterior via the anus (cloacal opening) over time compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 The descendants of the AB blastomere exhibit variations in developmental programs compared to their counterparts in control animals. AB lineage abnormal C_elegans_phenotype_ontology WBPhenotype:0000097 AB lineage variant The descendants of the AB blastomere exhibit variations in developmental programs compared to their counterparts in control animals. WB:WBPaper00001584 WB:WBPerson2021 Any variation in the progression of the cells that form a narrow passage connecting the posterior bulb of the pharynx to the anterior intestine over time compared to control. In C. elegans this valve is composed of 3 pairs of cells each forming a flattened disc-like ring and is lined by a layer of cuticle (Wormatlas). pharyngeal intestinal valve development abnormal C_elegans_phenotype_ontology WBPhenotype:0000098 pharyngeal intestinal valve development variant Any variation in the progression of the cells that form a narrow passage connecting the posterior bulb of the pharynx to the anterior intestine over time compared to control. In C. elegans this valve is composed of 3 pairs of cells each forming a flattened disc-like ring and is lined by a layer of cuticle (Wormatlas). WB:WBPerson2021 WB:WBPerson557 The descendants of any of the P precursor cells exhibit variations in developmental programs compared to their counterparts in control animals. P lineages abnormal C_elegans_phenotype_ontology WBPhenotype:0000099 P lineages variant The descendants of any of the P precursor cells exhibit variations in developmental programs compared to their counterparts in control animals. WB:WBPerson2021 Cells exhibit variations in their response to ultraviolet radiation compared to that observed in control animals. cell UV response abnormal C_elegans_phenotype_ontology WBPhenotype:0000100 cell UV response variant Cells exhibit variations in their response to ultraviolet radiation compared to that observed in control animals. WB:WBPerson557 Animals exhibit an increase in the extent of activation of programmed cell death by exposure to the nucleic acid damaging agent, UV irradiation, compared to control. C_elegans_phenotype_ontology WBPhenotype:0000101 UV induced apoptosis increased Animals exhibit an increase in the extent of activation of programmed cell death by exposure to the nucleic acid damaging agent, UV irradiation, compared to control. WB:WBPerson712 Animals display variations in the organization, accumulation or distribution of transmitter-containing membrane-bound organelles (synaptic vesicles) compared to that observed in control animals. presynaptic vesicle cluster abnormal C_elegans_phenotype_ontology synaptic vesicle cluster abnormal WBPhenotype:0000102 presynaptic vesicle cluster variant Animals display variations in the organization, accumulation or distribution of transmitter-containing membrane-bound organelles (synaptic vesicles) compared to that observed in control animals. WB:WBPaper00027305 Any variation in the progression of the different inclusions within the intestinal cytoplasm, including birefringent crystalline objects and other dark-staining endosomes over time compared to control. In C. elegans these contents might include glycogen granules (polysaccharide storage), rhabditin (carbohydrate storage), yolk granules (lipid and protein), and concentrated waste products (Wormatlas). gut granule development abnormal C_elegans_phenotype_ontology WBPhenotype:0000103 gut granule development variant Any variation in the progression of the different inclusions within the intestinal cytoplasm, including birefringent crystalline objects and other dark-staining endosomes over time compared to control. In C. elegans these contents might include glycogen granules (polysaccharide storage), rhabditin (carbohydrate storage), yolk granules (lipid and protein), and concentrated waste products (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Contents or structures of a cell are no longer restricted/localized to their typical positions within the cell. cell polarity abnormal C_elegans_phenotype_ontology WBPhenotype:0000104 cell polarity variant Contents or structures of a cell are no longer restricted/localized to their typical positions within the cell. WB:WBPaper00031356 WB:WBPerson2021 WB:WBPerson712 Variations in the progression of a developing oocyte, from diakinesis to metaphase (meiosis I), in response to a signal compared to control animals. Meiotic maturation is accompanied by nuclear envelope breakdown (germinal vesicle breakdown), cytoskeletal rearrangement and meiotic spindle assembly. Oma oocyte meiotic maturation abnormal C_elegans_phenotype_ontology WBPhenotype:0000105 oocyte meiotic maturation variant Variations in the progression of a developing oocyte, from diakinesis to metaphase (meiosis I), in response to a signal compared to control animals. Meiotic maturation is accompanied by nuclear envelope breakdown (germinal vesicle breakdown), cytoskeletal rearrangement and meiotic spindle assembly. GO:0001556 WB:WBPaper00026997 WB:WBPerson2021 Variations in the processes that negatively regulate the meiotic progression of oocytes (exit from diakinesis) in the absence of a signal compared to control animals. inhibition of oocyte maturation abnormal C_elegans_phenotype_ontology WBPhenotype:0000106 inhibition of oocyte maturation variant Variations in the processes that negatively regulate the meiotic progression of oocytes (exit from diakinesis) in the absence of a signal compared to control animals. WB:WBPaper00003371 WB:WBPaper00026997 WB:WBPerson2021 Any variation that alters the control mechanisms that inhibit oocyte maturation and release of a mature oocyte into the spermatheca (for subsequent fertilization), compared to control. inhibition of ovulation abnormal C_elegans_phenotype_ontology WBPhenotype:0000107 inhibition of ovulation variant Any variation that alters the control mechanisms that inhibit oocyte maturation and release of a mature oocyte into the spermatheca (for subsequent fertilization), compared to control. GO:0060280 WB:WBPerson2021 WB:WBPerson557 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000108 obsolete severe dumpy true OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000109 obsolete moderate dumpy true OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000110 obsolete slightly dumpy true Any variation in the cellular or subcellular distribution of a gene product compared to that observed in control animals. pattern of gene expression abnormal C_elegans_phenotype_ontology WBPhenotype:0000111 pattern of gene expression variant Any variation in the cellular or subcellular distribution of a gene product compared to that observed in control animals. WB:WBPerson2021 Variations in the biogenesis and stability of protein molecules compared to control. protein expression abnormal C_elegans_phenotype_ontology WBPhenotype:0000112 protein expression variant Variations in the biogenesis and stability of protein molecules compared to control. WB:WBPerson2021 Variations in the biogenesis and stability of any class of RNA molecules (rRNAs, miRNAs, tRNAs etc) compared to control. RNA expression abnormal C_elegans_phenotype_ontology WBPhenotype:0000113 RNA expression variant Variations in the biogenesis and stability of any class of RNA molecules (rRNAs, miRNAs, tRNAs etc) compared to control. WB:WBPerson2021 Variations in the biogenesis and stability of messenger RNA molecules compared to control. mRNA expression abnormal C_elegans_phenotype_ontology WBPhenotype:0000114 mRNA expression variant Variations in the biogenesis and stability of messenger RNA molecules compared to control. GO:0050684 WB:WBPerson2021 Any variation in the progression of the anterior portion of the pharynx over time compared to control. In C. elegans the anterior region includes the corpus (procorpus and metacorpus - first bulb). anterior pharynx abnormal C_elegans_phenotype_ontology WBPhenotype:0000115 anterior pharynx variant Any variation in the progression of the anterior portion of the pharynx over time compared to control. In C. elegans the anterior region includes the corpus (procorpus and metacorpus - first bulb). WB:WBPerson2021 WB:WBPerson557 Animals die in between the early and late larval stages. In C. elegans, this occurs during the L2- L3 larval stages of the life cycle. Let Lvl C_elegans_phenotype_ontology WBPhenotype:0000116 mid larval lethal Animals die in between the early and late larval stages. In C. elegans, this occurs during the L2- L3 larval stages of the life cycle. WB:WBPerson2021 Animals die at the L1 stage of the life cycle. Let Lvl C_elegans_phenotype_ontology WBPhenotype:0000117 L1 lethal Animals die at the L1 stage of the life cycle. WB:WBPerson2021 L2 lethal: Animals die at the L2 stage of the life cycle. Let Lvl C_elegans_phenotype_ontology WBPhenotype:0000118 L2 lethal L2 lethal: Animals die at the L2 stage of the life cycle. WB:WBPerson2021 Any change that results in higher than normal levels of protein expression compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000119 protein expression increased Any change that results in higher than normal levels of protein expression compared to control animals. WB:WBPerson557 Any change that results in lower than normal levels of protein expression compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000120 protein expression reduced Any change that results in lower than normal levels of protein expression compared to control animals. WB:kmva Variations in the chemical reactions and pathways resulting in the formation of a protein, compared to control. translation abnormal C_elegans_phenotype_ontology protein synthesis abnormal WBPhenotype:0000121 translation variant Variations in the chemical reactions and pathways resulting in the formation of a protein, compared to control. GO:0006412 WB:WBPerson2021 Any variation in the posttranslational modification of a protein (which may include cleavage of peptide bonds) leading to the attainment of the full functional capacity of the protein compared to control. post translational processing abnormal C_elegans_phenotype_ontology protein processing variant WBPhenotype:0000122 post translational processing variant Any variation in the posttranslational modification of a protein (which may include cleavage of peptide bonds) leading to the attainment of the full functional capacity of the protein compared to control. GO:0016485 WB:WBPerson2021 WB:WBPerson557 Variations that cause a decrease in the expression level of a biological catalyst, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000123 enzyme expression level reduced Variations that cause a decrease in the expression level of a biological catalyst, compared to control animals. WB:WBPerson2021 Any variation that results in a decrease in the catalytic activity of an enzyme compared to control. Catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component). C_elegans_phenotype_ontology WBPhenotype:0000124 enzyme activity reduced Any variation that results in a decrease in the catalytic activity of an enzyme compared to control. Catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component). WB:WBPerson2021 WB:WBPerson557 Any variation that results in an increase in the catalytic activity of an enzyme compared to control. Catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component). C_elegans_phenotype_ontology WBPhenotype:0000125 enzyme activity increased Any variation that results in an increase in the catalytic activity of an enzyme compared to control. Catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component). WB:WBPerson2021 WB:WBPerson557 Variations in the time from pronuclei meeting to furrow initiation during the first cell division compared to control animals. Emb general pace of development abnormal C_elegans_phenotype_ontology WBPhenotype:0000126 general pace of development defective early emb Variations in the time from pronuclei meeting to furrow initiation during the first cell division compared to control animals. WB:cab WB:cgc7141 Characteristic exit from the dauer stage is altered compared to control animals. dauer recovery abnormal C_elegans_phenotype_ontology WBPhenotype:0000127 dauer recovery variant Characteristic exit from the dauer stage is altered compared to control animals. WB:cab Animals are more likely to form dauers at temperatures that do not induce dauer entry in control animals. Hid C_elegans_phenotype_ontology WBPhenotype:0000128 temperature induced dauer formation increased Animals are more likely to form dauers at temperatures that do not induce dauer entry in control animals. WB:cgc424 Animals do not enter dauer at a temperature that induces dauer formation in control animals. C_elegans_phenotype_ontology WBPhenotype:0000129 temperature induced dauer formation defective Animals do not enter dauer at a temperature that induces dauer formation in control animals. WB:WBPerson2021 WB:WBPerson557 Animals enter the dauer stage when exposed to lower concentrations or shorter exposure times of chemicals that induce dauer formation compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0000130 pheromone induced dauer formation enhanced Animals enter the dauer stage when exposed to lower concentrations or shorter exposure times of chemicals that induce dauer formation compared to that observed in control animals. WB:WBPerson2021 WB:WBPerson557 Animals do not enter dauer when exposed to chemicals that induce dauer formation in control animals. Phd C_elegans_phenotype_ontology WBPhenotype:0000131 pheromone induced dauer formation defective Animals do not enter dauer when exposed to chemicals that induce dauer formation in control animals. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the entry into the dauer stage when exposed to concentrations of chemicals that induce dauer formation in control animals. pheromone induced dauer formation abnormal C_elegans_phenotype_ontology WBPhenotype:0000132 pheromone induced dauer formation variant Animals exhibit variations in the entry into the dauer stage when exposed to concentrations of chemicals that induce dauer formation in control animals. WB:WBPerson2021 WB:WBPerson557 The levels of an enzyme involved in the manufacture of lipids are decreased compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000133 expression lipogenic enzyme reduced The levels of an enzyme involved in the manufacture of lipids are decreased compared to control animals. WB:WBPerson2021 Animals exhibit a decrease in the intensity of expression of a gene product compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0000134 gene expression level reduced Animals exhibit a decrease in the intensity of expression of a gene product compared to that observed in control animals. WB:WBPerson2021 Animals exhibit an increase in the intensity of expression of a gene product compared to that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0000135 gene expression level high Animals exhibit an increase in the intensity of expression of a gene product compared to that observed in control animals. WB:WBPerson2021 Animals exhibit elevated levels of messenger RNA compared to control. C_elegans_phenotype_ontology WBPhenotype:0000136 mRNA levels increased Animals exhibit elevated levels of messenger RNA compared to control. WB:WBPaper00033456 WB:WBPerson2021 Animals exhibit decreased levels of messenger RNA compared to control. C_elegans_phenotype_ontology WBPhenotype:0000137 mRNA levels reduced Animals exhibit decreased levels of messenger RNA compared to control. WB:WBPaper00033456 WB:WBPerson2021 The constituent parts or ratio of elements that make up lipids are altered when compared to that of control animals. lipid composition abnormal C_elegans_phenotype_ontology fat composition abnormal fatty acid composition abnormal WBPhenotype:0000138 lipid composition variant The constituent parts or ratio of elements that make up lipids are altered when compared to that of control animals. WB:WBPerson712 Animals exhibit variations in survival when exposed to stress stimuli that induce lethality in control animals. stress induced lethality abnormal C_elegans_phenotype_ontology WBPhenotype:0000139 stress induced lethality variant Animals exhibit variations in survival when exposed to stress stimuli that induce lethality in control animals. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in cessation of development when exposed to stress stimuli that induce developmental arrest in control animals. stress induced arrest abnormal C_elegans_phenotype_ontology WBPhenotype:0000140 stress induced arrest variant Animals exhibit variations in cessation of development when exposed to stress stimuli that induce developmental arrest in control animals. WB:WBPerson2021 WB:WBPerson557 Animal populations exhibit a further decrease in survival when exposed to stress stimuli compared to the lethality rate observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0000141 stress induced lethality increased Animal populations exhibit a further decrease in survival when exposed to stress stimuli compared to the lethality rate observed in control animals. WB:WBPerson2021 WB:WBPerson557 Variations in the activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress, compared to control. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). cell stress response abnormal C_elegans_phenotype_ontology WBPhenotype:0000142 cell stress response variant Variations in the activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress, compared to control. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). GO:0033554 WB:WBPerson2021 Animals exhibit variations in their response to ultraviolet radiation compared to that observed in control animals. organism UV response abnormal C_elegans_phenotype_ontology WBPhenotype:0000143 organism UV response variant Animals exhibit variations in their response to ultraviolet radiation compared to that observed in control animals. WB:WBPerson557 Animals exhibit an increase in the extent of activation of programmed cell death by exposure to a pathogen or pathogenic cue, compared to control. C_elegans_phenotype_ontology WBPhenotype:0000144 pathogen induced cell death increased Animals exhibit an increase in the extent of activation of programmed cell death by exposure to a pathogen or pathogenic cue, compared to control. WB:WBPerson712 Animals exhibit variations in the time of onset or duration of the fertile period, or production of new individuals that contain some portion of their genetic material inherited from that organism compared to control. fertility variant fertility abnormal C_elegans_phenotype_ontology WBPhenotype:0000145 fertility phenotype Animals exhibit variations in the time of onset or duration of the fertile period, or production of new individuals that contain some portion of their genetic material inherited from that organism compared to control. GO:0000003 WB:WBPerson2021 WB:WBPerson557 Animals do not respond to changes in temperature or thermal stress in the same manner as control animals. In C.elegans this is often measured by changes in the expression of stress proteins or changes in life span. organism temperature response abnormal C_elegans_phenotype_ontology WBPhenotype:0000146 organism temperature response variant Animals do not respond to changes in temperature or thermal stress in the same manner as control animals. In C.elegans this is often measured by changes in the expression of stress proteins or changes in life span. WB:WBPerson712 Any variation in the state or activity of an organism as a result of deprivation of nourishment, compared to control. organism starvation response abnormal C_elegans_phenotype_ontology WBPhenotype:0000147 organism starvation response variant Any variation in the state or activity of an organism as a result of deprivation of nourishment, compared to control. GO:0042594 WB:WBPerson2021 Animals exhibit variations in the entry into the dauer stage when exposed to nutrient poor conditions that induce dauer formation in control animals. starvation induced dauer formation abnormal C_elegans_phenotype_ontology WBPhenotype:0000148 starvation induced dauer formation variant Animals exhibit variations in the entry into the dauer stage when exposed to nutrient poor conditions that induce dauer formation in control animals. WB:WBPerson2021 WB:WBPerson557 Animals are more likely to form dauers under nutrient conditions that do not induce dauer entry in control animals. C_elegans_phenotype_ontology WBPhenotype:0000149 starvation induced dauer formation increased Animals are more likely to form dauers under nutrient conditions that do not induce dauer entry in control animals. WB:WBPerson2021 WB:WBPerson557 Animals do not enter dauer under nutrient-poor conditions that induce dauer formation in control animals. C_elegans_phenotype_ontology WBPhenotype:0000150 starvation induced dauer formation defective Animals do not enter dauer under nutrient-poor conditions that induce dauer formation in control animals. WB:WBPerson2021 WB:WBPerson557 Embryos generate an excess number of anterior derived pharyngeal cells. In C. elegans, embryos generate an excess number of AB blastomere-derived pharyngeal cells. This hyperinduction of anterior pharyngeal tissue is associated with defects in fate specification of the ABp blastomere. Apx C_elegans_phenotype_ontology WBPhenotype:0000151 anterior pharynx extra cells Embryos generate an excess number of anterior derived pharyngeal cells. In C. elegans, embryos generate an excess number of AB blastomere-derived pharyngeal cells. This hyperinduction of anterior pharyngeal tissue is associated with defects in fate specification of the ABp blastomere. WB:WBPaper00001930 WB:WBPerson2021 One-cell embryos do not form the shallow groove in the cell surface near the old metaphase plate at the onset of cytokinesis. Emb C_elegans_phenotype_ontology WBPhenotype:0000152 no cleavage furrow first division early emb One-cell embryos do not form the shallow groove in the cell surface near the old metaphase plate at the onset of cytokinesis. GO:0032154 WB:WBPerson2021 WB:WBPerson557 Initiation, strength, extent or cessation of body wall muscle activity that results in the shortening of the muscle, is aberrant compared to control animals. body wall contraction variant body wall contraction abnormal C_elegans_phenotype_ontology WBPhenotype:0000153 body wall muscle contraction abnormal Initiation, strength, extent or cessation of body wall muscle activity that results in the shortening of the muscle, is aberrant compared to control animals. WB:WBPaper00032190 WB:WBPerson712 The characteristic number of offspring produced is lower compared to that of control animals. C_elegans_phenotype_ontology WBPhenotype:0000154 reduced brood size The characteristic number of offspring produced is lower compared to that of control animals. WB:WBPerson557 Contents or structures of the cell are oriented on the opposite side of the cell compared to control animals; In C. elegans, this can result in the fate pattern of descendants being flipped. C_elegans_phenotype_ontology WBPhenotype:0000155 cell polarity reversed Contents or structures of the cell are oriented on the opposite side of the cell compared to control animals; In C. elegans, this can result in the fate pattern of descendants being flipped. WB:WBPaper00031356 WB:WBPerson2021 WB:WBPerson712 Any variation in the time interval between successive contractions of the body wall muscles during the defecation motor program compared to cantrol. body wall contraction interval abnormal C_elegans_phenotype_ontology body wall muscle contraction interval abnormal WBPhenotype:0000156 body wall muscle contraction interval during defecation abnormal Any variation in the time interval between successive contractions of the body wall muscles during the defecation motor program compared to cantrol. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the sustained posterior body muscle contractions that precede the remaining contractions of the defecation cycle compared to control animals. pBoc posterior body wall contraction abnormal C_elegans_phenotype_ontology posterior body contraction abnormal posterior body wall contraction defective WBPhenotype:0000157 posterior body wall contraction defecation cycle variant Animals exhibit variations in the sustained posterior body muscle contractions that precede the remaining contractions of the defecation cycle compared to control animals. WB:WBPaper00031426 WB:WBPerson712 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000158 obsolete posterior body wall shortened interval true OBSOLETE: Animals exhibit variations in the entry/exit into a state of arrested tissue development during the dauer larval stage in response to harsh environmental conditions, compared to control. In C. elegans, the dauer larva enters a state of arrest in which no developmental changes occur, until the animal finds more suitable growing conditions, or until it spontaneously shifts back into a normal developmental schedule. (WormAtlas). C_elegans_phenotype_ontology WBPhenotype:0000159 obsolete dauer arrest variant true OBSOLETE: Animals exhibit variations in the entry/exit into a state of arrested tissue development during the dauer larval stage in response to harsh environmental conditions, compared to control. In C. elegans, the dauer larva enters a state of arrest in which no developmental changes occur, until the animal finds more suitable growing conditions, or until it spontaneously shifts back into a normal developmental schedule. (WormAtlas). WB:WBPerson2021 WB:WBPerson557 Embryos do not form a defined shallow groove in the cell surface near the old metaphase plate at the onset of cytokinesis. Emb C_elegans_phenotype_ontology WBPhenotype:0000160 cleavage furrow not discrete early emb Embryos do not form a defined shallow groove in the cell surface near the old metaphase plate at the onset of cytokinesis. GO:0032154 WB:WBPerson2021 WB:WBPerson557 Any variation in the rotation of centrosomes and associated pronuclei in one-cell embryo, occurring as a transition between pronuclear migration and pronuclear fusion compared to control. nuclear rotation abnormal C_elegans_phenotype_ontology WBPhenotype:0000161 nuclear rotation variant Any variation in the rotation of centrosomes and associated pronuclei in one-cell embryo, occurring as a transition between pronuclear migration and pronuclear fusion compared to control. GO:0035047 WB:WBPerson2021 WB:WBPerson557 Larva show deficiencies in chroma resulting in increased translucency. C_elegans_phenotype_ontology translucent WBPhenotype:0000162 pale larva Larva show deficiencies in chroma resulting in increased translucency. WB:WBPerson2021 WB:WBPerson557 Larva appear unusually transparent when compared to control. Clr C_elegans_phenotype_ontology transparent WBPhenotype:0000163 clear larva Larva appear unusually transparent when compared to control. WB:WBPerson557 Animals exhibit a reduced girth compared to a control animal of the same developmental stage. C_elegans_phenotype_ontology decreased girth slim WBPhenotype:0000164 thin Animals exhibit a reduced girth compared to a control animal of the same developmental stage. WB:WBPerson712 Variations in the ability of two or more individual cells to form a syncytium (a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane) via the fusion of the plasma membranes. Cell fusion is dependent on the merging of lipid bilayer membranes as well as cytoplasmic mixing. cell fusion abnormal C_elegans_phenotype_ontology WBPhenotype:0000165 cell fusion variant Variations in the ability of two or more individual cells to form a syncytium (a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane) via the fusion of the plasma membranes. Cell fusion is dependent on the merging of lipid bilayer membranes as well as cytoplasmic mixing. GO:0000768 GO:0045026 WB:WBPaper00005122 WB:WBPerson2021 Variations in the ability of seam cells to fuse to form a continuous syncytium along the body wall late larval development, (separate from the hyp 7 syncytium), compared to control (WormAtlas). Hypodermal seam cells lie along the lateral body wall to form longitudinal stripes of epithelial cells underlying the alae, and are required for alae formation. seam cell fusion abnormal C_elegans_phenotype_ontology WBPhenotype:0000166 seam cell fusion variant Variations in the ability of seam cells to fuse to form a continuous syncytium along the body wall late larval development, (separate from the hyp 7 syncytium), compared to control (WormAtlas). Hypodermal seam cells lie along the lateral body wall to form longitudinal stripes of epithelial cells underlying the alae, and are required for alae formation. WB:WBPerson2021 WB:WBPerson557 Seam cells fuse to form a continuous syncytium along the body wall at an earlier stage of development compared to control. C_elegans_phenotype_ontology WBPhenotype:0000167 precocious seam cell fusion Seam cells fuse to form a continuous syncytium along the body wall at an earlier stage of development compared to control. WB:WBPerson2021 WB:WBPerson557 Variations in the regulated release of proteins needed for alae formation by epidermal seam cells compared to control. Alae are small linear ridges running along the lateral lines of the cuticle, lengthwise along the body (WormAtlas). alae secretion abnormal C_elegans_phenotype_ontology alae formation variant WBPhenotype:0000168 alae secretion variant Variations in the regulated release of proteins needed for alae formation by epidermal seam cells compared to control. Alae are small linear ridges running along the lateral lines of the cuticle, lengthwise along the body (WormAtlas). WB:WBPaper00004833 WB:WBPaper00025242 WB:WBPerson2021 Cells leave the M phase (mitosis and cytokinesis) at an earlier time than sister or other control cells. C_elegans_phenotype_ontology WBPhenotype:0000169 early exit cell cycle Cells leave the M phase (mitosis and cytokinesis) at an earlier time than sister or other control cells. GO:0010458 WB:WBPerson557 WB:WBPerson712 Formation of alae occurs earlier in development compared to control animals; In C. elegans, adult lateral alae are typically generated during the late L4 stage. C_elegans_phenotype_ontology WBPhenotype:0000170 precocious alae Formation of alae occurs earlier in development compared to control animals; In C. elegans, adult lateral alae are typically generated during the late L4 stage. WB:cab pmid:3428573 Any aberrancy in the processes that govern expansion of cell populations compared to control animals. cell proliferation abnormal C_elegans_phenotype_ontology WBPhenotype:0000171 cell proliferation variant Any aberrancy in the processes that govern expansion of cell populations compared to control animals. GO:0008283 WB:WBPerson2021 The processes governing the expansion of cell populations are altered compared to control animals, such that cell populations are increased. C_elegans_phenotype_ontology WBPhenotype:0000172 cell proliferation increased The processes governing the expansion of cell populations are altered compared to control animals, such that cell populations are increased. WB:WBPerson2021 The processes governing the expansion of cell populations are altered compared to control animals, such that cell populations are decreased. C_elegans_phenotype_ontology WBPhenotype:0000173 cell proliferation reduced The processes governing the expansion of cell populations are altered compared to control animals, such that cell populations are decreased. WB:WBPerson2021 Any variation in the progression of the layer of connective tissue over the surface of tissues that serves to separate it from neighboring tissues, from its formation to its mature structure compared to control (Wormatlas). basal lamina development abnormal C_elegans_phenotype_ontology WBPhenotype:0000174 basal lamina development variant Any variation in the progression of the layer of connective tissue over the surface of tissues that serves to separate it from neighboring tissues, from its formation to its mature structure compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Excessive and often uncoordinated body wall muscle contraction leading to shortening of the body. C_elegans_phenotype_ontology WBPhenotype:0000175 hypercontracted Excessive and often uncoordinated body wall muscle contraction leading to shortening of the body. WB:WBPerson363 Any variation in the specific actions or reactions of an animal after completion of feeding, typically after a fast, compared to that observed in control animals. In C. elegans worms become behaviorally quiescent and cease feeding and moving when sated. satiety behavior abnormal C_elegans_phenotype_ontology WBPhenotype:0000176 satiety behavior variant Any variation in the specific actions or reactions of an animal after completion of feeding, typically after a fast, compared to that observed in control animals. In C. elegans worms become behaviorally quiescent and cease feeding and moving when sated. WB:WBPerson2021 WB:WBPerson557 Any variation that results in a decrease of acetylcholine esterase levels, compared to control. C_elegans_phenotype_ontology WBPhenotype:0000177 acetylcholinesterase reduced Any variation that results in a decrease of acetylcholine esterase levels, compared to control. WB:WBPaper00024452 WB:WBPerson2021 Cells are observed to undergo a dramatic decrease in cell volume, collapse of the vacuoles, and complete disintegration of the plasma membrane and most organelles. C_elegans_phenotype_ontology WBPhenotype:0000178 cell degeneration Cells are observed to undergo a dramatic decrease in cell volume, collapse of the vacuoles, and complete disintegration of the plasma membrane and most organelles. WB:WBPerson712 Cells specialized for receiving, conducting and transmitting impulses in the nervous system are observed to undergo a dramatic decrease in cell volume, collapse of the vacuoles and processes, and complete disintegration of the plasma membrane and most organelles. C_elegans_phenotype_ontology WBPhenotype:0000179 neuron degeneration Cells specialized for receiving, conducting and transmitting impulses in the nervous system are observed to undergo a dramatic decrease in cell volume, collapse of the vacuoles and processes, and complete disintegration of the plasma membrane and most organelles. WB:WBPerson712 WB:WBperson557 Animals display variations in the structure, organization of components, or spatial pattern of the projection that conducts signal away from the cell body, compared to that observed in control animals. axon morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000180 axon morphology variant Animals display variations in the structure, organization of components, or spatial pattern of the projection that conducts signal away from the cell body, compared to that observed in control animals. GO:0030424 WB:WBPaper00005236 WB:WBPerson712 Animals display variations in the directed path taken by the axon compared to the path the nerve fiber follows in the nervous system in control animals. axon trajectory abnormal C_elegans_phenotype_ontology WBPhenotype:0000181 axon trajectory variant Animals display variations in the directed path taken by the axon compared to the path the nerve fiber follows in the nervous system in control animals. WB:WBPaper00001105 WB:WBPerson712 Any perturbation that causes a decrease in the frequency of cell death by apoptosis compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000182 apoptosis reduced Any perturbation that causes a decrease in the frequency of cell death by apoptosis compared to control animals. GO:0043065 WB:WBPerson2021 Any perturbation that causes an elevation in the frequency of cell death by apoptosis compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000183 apoptosis increased Any perturbation that causes an elevation in the frequency of cell death by apoptosis compared to control animals. GO:0043066 WB:WBPerson2021 Cells do not undergo the form of programmed cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), classically little or no ultrastructural modifications of cytoplasmic organelles, plasma membrane blebbing (but maintenance of its integrity until the final stages of the process) and engulfment by resident phagocytes. C_elegans_phenotype_ontology WBPhenotype:0000184 apoptosis fails to occur Cells do not undergo the form of programmed cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), classically little or no ultrastructural modifications of cytoplasmic organelles, plasma membrane blebbing (but maintenance of its integrity until the final stages of the process) and engulfment by resident phagocytes. WB:WBPerson712 Animals exhibit a decreased pace of the programmed cell death pathway, compared to that observed for control cells. C_elegans_phenotype_ontology WBPhenotype:0000185 apoptosis protracted Animals exhibit a decreased pace of the programmed cell death pathway, compared to that observed for control cells. WB:WBPerson712 Any aberrancy in the processes that influence the generation and maturation of oocytes compared to control animals. WBPhenotype:0000896 oocyte germ cell differentiation abnormal oogenesis abnormal C_elegans_phenotype_ontology oocyte development abnormal WBPhenotype:0000186 oogenesis variant Any aberrancy in the processes that influence the generation and maturation of oocytes compared to control animals. GO:0048477 WB:WBPerson2021 The overall structure or appearance of fertilized oocytes that are laid has every part of their surface equidistant from the center. C_elegans_phenotype_ontology WBPhenotype:0000187 egg round The overall structure or appearance of fertilized oocytes that are laid has every part of their surface equidistant from the center. WB:WBPerson2021 WB:WBPerson557 Any variation in the 'arm-like' form, structure or composition of the specialized tissue of the reproductive tract that produces gametes compared to control. In C. elegans the reproductive tract in the hermaphrodite has two equivalent gonad 'arms', while the male has a one-armed gonad. gonad arm morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000188 gonad arm morphology variant Any variation in the 'arm-like' form, structure or composition of the specialized tissue of the reproductive tract that produces gametes compared to control. In C. elegans the reproductive tract in the hermaphrodite has two equivalent gonad 'arms', while the male has a one-armed gonad. WB:WBPerson2021 WB:WBPerson557 Hypodermal cells fail to be organized in the same manner as observed in control animals. In C. elegans, hypodermal cells typically organize into distinct dorsal, lateral and ventral rows and cover the entire body. C_elegans_phenotype_ontology WBPhenotype:0000189 hypodermis disorganized Hypodermal cells fail to be organized in the same manner as observed in control animals. In C. elegans, hypodermal cells typically organize into distinct dorsal, lateral and ventral rows and cover the entire body. WB:WBPaper00027006 WB:WBPerson2021 Animals fail to exit from the facultative diapause of the dauer larval stage of nematode development. C_elegans_phenotype_ontology WBPhenotype:0000190 no dauer recovery Animals fail to exit from the facultative diapause of the dauer larval stage of nematode development. GO:0043054 WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in their response to a situation when there is too high a density of nematodes to be supported by the available amount of food and space compared to that observed in control animals (Wormatlas). organism crowding response abnormal C_elegans_phenotype_ontology WBPhenotype:0000191 organism crowding response variant Animals exhibit variations in their response to a situation when there is too high a density of nematodes to be supported by the available amount of food and space compared to that observed in control animals (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation that results in the misregulation of enzymatic activity such that catalysis occurs at a constant rate regardless of physiological demand or the concentration of a substrate. C_elegans_phenotype_ontology WBPhenotype:0000192 constitutive enzyme activity Any variation that results in the misregulation of enzymatic activity such that catalysis occurs at a constant rate regardless of physiological demand or the concentration of a substrate. WB:WBPerson2021 WB:WBPerson557 Any variation within an enzyme that causes it to act antagonistically towards the wild-type enzymatic product. These mutations usually result in an altered molecular function (often inactive) and are characterized by a dominant or semi-dominant phenotype. C_elegans_phenotype_ontology WBPhenotype:0000193 dominant negative enzyme Any variation within an enzyme that causes it to act antagonistically towards the wild-type enzymatic product. These mutations usually result in an altered molecular function (often inactive) and are characterized by a dominant or semi-dominant phenotype. WB:WBPerson2021 Variations in the placement of the polar body formed in the first division of meiosis of a primary oocyte, compared to control. A polar body is the by-product of meiosis (destined to degenerate) in female or hermaphrodite animals. first polar body position abnormal C_elegans_phenotype_ontology WBPhenotype:0000194 first polar body position variant Variations in the placement of the polar body formed in the first division of meiosis of a primary oocyte, compared to control. A polar body is the by-product of meiosis (destined to degenerate) in female or hermaphrodite animals. WB:WBPerson2021 WB:WBPerson557 Variations in the migration pattern of distal tip cells compared to control animals. In C. elegans, DTCs located on the anterior and posterior ends of the gonad primordium typically migrate in a symmetrical U-shaped pattern. distal tip cell migration abnormal C_elegans_phenotype_ontology DTC migration abnormal WBPhenotype:0000195 distal tip cell migration variant Variations in the migration pattern of distal tip cells compared to control animals. In C. elegans, DTCs located on the anterior and posterior ends of the gonad primordium typically migrate in a symmetrical U-shaped pattern. GO:0040039 WB:WBPaper00003598 WB:WBPerson2021 The morphological appearance of distal tip cells is varied compared to control animals. distal tip cell morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000196 distal tip cell morphology variant The morphological appearance of distal tip cells is varied compared to control animals. WB:cab Variations in a cell's ability to influence the fate of another cell (often of different developmental potential or ancestry via short range signaling). cell induction abnormal C_elegans_phenotype_ontology WBPhenotype:0000197 cell induction variant Variations in a cell's ability to influence the fate of another cell (often of different developmental potential or ancestry via short range signaling). GO:0031128 WB:WBPerson2021 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000198 obsolete vulval cell induction abnormal true Any variation in the progression of the finger-like sensory sensilla that project from the tail and embed in the male fan from its formation to the mature structure when compared to control animals. male tail sensory ray development abnormal C_elegans_phenotype_ontology WBPhenotype:0000199 male tail sensory ray development variant Any variation in the progression of the finger-like sensory sensilla that project from the tail and embed in the male fan from its formation to the mature structure when compared to control animals. WB:WBPerson2021 WB:WBPerson557 Variations in the progression of structures/tissues surrounding a cell over time from its initial formation to its mature form compared to control. pericellular component development abnormal C_elegans_phenotype_ontology WBPhenotype:0000200 pericellular component development variant Variations in the progression of structures/tissues surrounding a cell over time from its initial formation to its mature form compared to control. WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of the formation of the rigid external coating (which is secreted by the hypodermis, seam and some interfacial epithelial cells) over time compared to control animals (Wormatlas). cuticle development abnormal C_elegans_phenotype_ontology WBPhenotype:0000201 cuticle development variant Any variation in the progression of the formation of the rigid external coating (which is secreted by the hypodermis, seam and some interfacial epithelial cells) over time compared to control animals (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the small linear ridges running along the lateral lines of the cuticle, lengthwise along the body compared to control (Wormatlas). alae abnormal C_elegans_phenotype_ontology WBPhenotype:0000202 alae variant Any variation in the small linear ridges running along the lateral lines of the cuticle, lengthwise along the body compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the characteristic desensitization to a volatile organic chemo-attractive signal in a time-concentration dependent and reversible manner compared to control animals. odorant adaptation abnormal C_elegans_phenotype_ontology WBPhenotype:0000203 odorant adaptation variant Animals exhibit variations in the characteristic desensitization to a volatile organic chemo-attractive signal in a time-concentration dependent and reversible manner compared to control animals. WB:WBPerson2021 Variations in the anterior body muscle contraction (aBoc) step of the defecation cycle compared to control animals. Under normal conditions, anterior body wall muscles contract and pressurize the intestinal contents during the aBoc step. aBoc C_elegans_phenotype_ontology anterior body contraction abnormal anterior body contraction defective WBPhenotype:0000204 anterior body contraction defecation cycle variant Variations in the anterior body muscle contraction (aBoc) step of the defecation cycle compared to control animals. Under normal conditions, anterior body wall muscles contract and pressurize the intestinal contents during the aBoc step. WB:WBPerson2021 Any variation in the expulsion of gut contents compared to control. In C. elegans, this refers to the final step of the defecation cycle in which the intestinal muscle and anal depressor contractions further pressurize intestinal contents and open the anus to permit expulsion. expulsion abnormal C_elegans_phenotype_ontology Exp WBPhenotype:0000205 expulsion variant Any variation in the expulsion of gut contents compared to control. In C. elegans, this refers to the final step of the defecation cycle in which the intestinal muscle and anal depressor contractions further pressurize intestinal contents and open the anus to permit expulsion. WB:WBPerson2021 WB:WBPerson557 A non-sex chromosome fails to segregate away from its homologous chromosome, resulting in gametes with no or extra copies of the non-sex homolog. C_elegans_phenotype_ontology WBPhenotype:0000206 autosomal nondisjunction meiosis A non-sex chromosome fails to segregate away from its homologous chromosome, resulting in gametes with no or extra copies of the non-sex homolog. GO:0045143 WB:WBPerson712 Any variation in the stereotyped sequence of muscle contractions that result in defecation over a fixed time period compared to control . defecation cycle abnormal C_elegans_phenotype_ontology Dec WBPhenotype:0000207 defecation cycle variant Any variation in the stereotyped sequence of muscle contractions that result in defecation over a fixed time period compared to control . WB:WBPerson2021 WB:WBPerson557 The mean time between the onset of the defecation motor program is greater than that observed for control animals. C_elegans_phenotype_ontology Dec-l reduced rate of defecation WBPhenotype:0000208 long defecation cycle The mean time between the onset of the defecation motor program is greater than that observed for control animals. WB:WBPaper00002315 WB:WBPaper00031896 WB:WBPerson712 The mean time between the onset of the defecation motor program is shorter than that observed for control animals. posterior body wall shortened interval C_elegans_phenotype_ontology Dec-s fast Dec increased rate of defecation WBPhenotype:0000209 short defecation cycle The mean time between the onset of the defecation motor program is shorter than that observed for control animals. WB:WBPaper00002315 WB:WBPaper00031896 WB:WBPerson712 Any variation in the stereotyped muscle contractions that result in defecation compared to control . In C. elegans these contractions include posterior body contraction (pBoc), anterior body contraction (aBoc), expulsion of gut contents by enteric muscle contraction (Emc) and opening of anus (Exp). defecation contraction abnormal C_elegans_phenotype_ontology WBPhenotype:0000210 defecation contraction variant Any variation in the stereotyped muscle contractions that result in defecation compared to control . In C. elegans these contractions include posterior body contraction (pBoc), anterior body contraction (aBoc), expulsion of gut contents by enteric muscle contraction (Emc) and opening of anus (Exp). WB:WBPerson2021 WB:WBPerson557 The rhythmic contractions of the muscles coordinating the elimination of gut contents are no longer synchronized compared to control. C_elegans_phenotype_ontology defecation contraction mistimed WBPhenotype:0000211 defecation contraction asynchronous The rhythmic contractions of the muscles coordinating the elimination of gut contents are no longer synchronized compared to control. WB:WBPerson2021 WB:WBPerson557 Animals contain body regions that are more narrow or drawn together than adjacent body regions. C_elegans_phenotype_ontology WBPhenotype:0000212 body constriction Animals contain body regions that are more narrow or drawn together than adjacent body regions. WB:WBPerson2021 WB:WBPerson557 Variations in the progression of a zygote from formation (gamete fusion) to just prior to the first cell division compared to control. zygotic development abnormal C_elegans_phenotype_ontology WBPhenotype:0000213 zygotic development variant Variations in the progression of a zygote from formation (gamete fusion) to just prior to the first cell division compared to control. WB:WBPerson2021 WB:WBPerson557 Animals respond to alpha amanitin at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000214 alpha amanitin hypersensitive Animals respond to alpha amanitin at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 Animals lack all germline progenitor cells, thereby resulting in the complete absence of a germline. no germline C_elegans_phenotype_ontology WBPhenotype:0000215 no germ line Animals lack all germline progenitor cells, thereby resulting in the complete absence of a germline. WB:WBPaper00001477 WB:WBPerson2021 Any variation in the processes that govern acquisition of particular cell fates compared to control animals. cell fate specification abnormal C_elegans_phenotype_ontology WBPhenotype:0000216 cell fate specification variant Any variation in the processes that govern acquisition of particular cell fates compared to control animals. WB:kmva The time in which a muscle contraction event that controls feeding is increased compared to control. Contractions of the pharynx are necessary for bacterial uptake from the surrounding environment. C_elegans_phenotype_ontology WBPhenotype:0000217 prolonged pharyngeal contraction The time in which a muscle contraction event that controls feeding is increased compared to control. Contractions of the pharynx are necessary for bacterial uptake from the surrounding environment. WB:WBPerson2021 WB:WBPerson557 An excess number of vulval precursor cells receive an inductive signal leading to an increased number of VPCs adopting vulval fates compared to control animals. Hin overinduced C_elegans_phenotype_ontology WBPhenotype:0000218 vulval cell induction increased An excess number of vulval precursor cells receive an inductive signal leading to an increased number of VPCs adopting vulval fates compared to control animals. WB:WBPerson2021 Vulval precursor cells receive a decrease in inductive signal leading to fewer VPCs adopting vulval fates compared to control animals. underinduced C_elegans_phenotype_ontology WBPhenotype:0000219 vulval cell induction reduced Vulval precursor cells receive a decrease in inductive signal leading to fewer VPCs adopting vulval fates compared to control animals. WB:WBPerson2021 Any aberrancy in the processes that govern acquisition of vulval cell fates compared to control animals. vulva cell fate specification abnormal C_elegans_phenotype_ontology WBPhenotype:0000220 vulva cell fate specification variant Any aberrancy in the processes that govern acquisition of vulval cell fates compared to control animals. WB:WBPerson2021 Animals exhibit variations in any chemical reaction or pathway involving neurotransmitters compared to control animals. Neurotransmitters are any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. neurotransmitter metabolism abnormal C_elegans_phenotype_ontology WBPhenotype:0000221 neurotransmitter metabolism variant Animals exhibit variations in any chemical reaction or pathway involving neurotransmitters compared to control animals. Neurotransmitters are any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. GO:0042133 WB:WBPerson557 WB:WBPerson712 Animals exhibit variations in any chemical reaction or pathway involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter, compared to control. serotonin metabolism abnormal C_elegans_phenotype_ontology WBPhenotype:0000222 serotonin metabolism variant Animals exhibit variations in any chemical reaction or pathway involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter, compared to control. GO:0042428 WB:WBPerson557 WB:WBPerson712 Animals exhibit variations in any chemical reaction or pathway involving acetylcholine, compared to control. Acetylcholine is the acetic acid ester of the organic base choline. acetylcholine metabolism abnormal C_elegans_phenotype_ontology WBPhenotype:0000223 acetylcholine metabolism variant Animals exhibit variations in any chemical reaction or pathway involving acetylcholine, compared to control. Acetylcholine is the acetic acid ester of the organic base choline. GO:0008291 WB:WBPerson557 WB:WBPerson712 Animals do not contain or are unable to maintain a perceivable level of serotonin capable of initiating or maintaining serotonin-dependent cell activity. C_elegans_phenotype_ontology WBPhenotype:0000224 serotonin deficient Animals do not contain or are unable to maintain a perceivable level of serotonin capable of initiating or maintaining serotonin-dependent cell activity. WB:WBPerson712 Animals are unable to carry out the chemical reactions and pathways resulting in the formation of serotonin. C_elegans_phenotype_ontology WBPhenotype:0000225 serotonin synthesis defective Animals are unable to carry out the chemical reactions and pathways resulting in the formation of serotonin. GO:0042427 WB:WBPerson557 WB:WBPerson712 Animals are unable to carry out any chemical reaction or pathway resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter. C_elegans_phenotype_ontology WBPhenotype:0000226 serotonin catabolism defective Animals are unable to carry out any chemical reaction or pathway resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter. GO:0042429 WB:WBPerson557 WB:WBPerson712 The inability of a male to properly turn during mating behavior. In C. elegans, males typically turn via a sharp ventral arch of the tail, as he approaches either the hermaphrodite head or tail. male turning abnormal C_elegans_phenotype_ontology WBPhenotype:0000227 male turning defective The inability of a male to properly turn during mating behavior. In C. elegans, males typically turn via a sharp ventral arch of the tail, as he approaches either the hermaphrodite head or tail. GO:0034607 WB:WBPaper00000392 WB:WBPaper00002109 Animals accumulate a greater number of genetic lesions than control animals in the absence of an externally controlled mutagen. In C. elegans, this is often measured by observing the number of reversion events of a known mutant gene function over a couple generations. C_elegans_phenotype_ontology WBPhenotype:0000228 spontaneous mutation rate increased Animals accumulate a greater number of genetic lesions than control animals in the absence of an externally controlled mutagen. In C. elegans, this is often measured by observing the number of reversion events of a known mutant gene function over a couple generations. WB:WBPaper00000565 WB:WBPerson712 Animals are shorter and thinner than control animals at the same developmental stage. body size reduced C_elegans_phenotype_ontology Sma WBPhenotype:0000229 small Animals are shorter and thinner than control animals at the same developmental stage. WB:cab WB:cgc31 The girth of the region posterior to the vulva is reduced compared to that anterior to the vulva (the Wit phenotype). In C. elegans this phenotype is associated with anteriorward misplacement of the CAN neurons. C_elegans_phenotype_ontology Wit WBPhenotype:0000230 tail withered The girth of the region posterior to the vulva is reduced compared to that anterior to the vulva (the Wit phenotype). In C. elegans this phenotype is associated with anteriorward misplacement of the CAN neurons. WB:WBPaper00002795 WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the physical dimensions of its body compared to control animals of the same developmental stage. body size abnormal C_elegans_phenotype_ontology WBPhenotype:0000231 PATO:0000117. body size variant Animals exhibit variations in the physical dimensions of its body compared to control animals of the same developmental stage. WB:WBPerson712 Variation in the migration pattern of CAN neurons. In C. elegans, CAN neurons move posteriorly from their birthplace in the head to positions near the middle of the embryo. CAN cell migration abnormal C_elegans_phenotype_ontology WBPhenotype:0000232 CAN cell migration variant Variation in the migration pattern of CAN neurons. In C. elegans, CAN neurons move posteriorly from their birthplace in the head to positions near the middle of the embryo. WB:WBPaper00002795 WB:WBPerson2021 Animals exhibit variations in any chemical reaction or pathway involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline, compared to control. dopamine metabolism abnormal C_elegans_phenotype_ontology WBPhenotype:0000233 dopamine metabolism variant Animals exhibit variations in any chemical reaction or pathway involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline, compared to control. GO:0042417 WB:WBPerson557 WB:WBPerson712 Animals do not contain or are unable to maintain a the level of dopamine capable of initiating or maintaining dopamine-dependent cell activity compared to control animals. C_elegans_phenotype_ontology dopamine levels decreased WBPhenotype:0000234 dopamine deficient Animals do not contain or are unable to maintain a the level of dopamine capable of initiating or maintaining dopamine-dependent cell activity compared to control animals. WB:WBPerson712 Animals are unable to carry out the chemical reactions and pathways resulting in the formation of dopamine. C_elegans_phenotype_ontology WBPhenotype:0000235 dopamine synthesis defective Animals are unable to carry out the chemical reactions and pathways resulting in the formation of dopamine. GO:0042416 WB:WBPerson557 WB:WBPerson712 Animals are unable to carry outany chemical reaction or pathway resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. C_elegans_phenotype_ontology WBPhenotype:0000236 dopamine catabolism defective Animals are unable to carry outany chemical reaction or pathway resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. GO:0042420 WB:WBPerson557 WB:WBPerson712 Animals extend intensity of roaming and or dwelling activity compared to control animals. In C. elegans, hyperactivity may include an increase in nose-lifts per minute. C_elegans_phenotype_ontology WBPhenotype:0000237 foraging hyperactive Animals extend intensity of roaming and or dwelling activity compared to control animals. In C. elegans, hyperactivity may include an increase in nose-lifts per minute. WB:WBPaper00031455 WB:WBPaper00031570 WB:WBPerson712 Animals decrease intensity or rate of roaming and or dwelling activity compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000238 foraging reduced Animals decrease intensity or rate of roaming and or dwelling activity compared to control animals. WB:WBPaper00031455 WB:WBPerson712 The descendants of a vulval precursor cell exhibit altered developmental programs compared to their counterparts in control animals. In C. elegans, the VPCs are P3.p-P8.p. vulval cell lineage abnormal C_elegans_phenotype_ontology VPC lineage abnormal WBPhenotype:0000239 vulval cell lineage variant The descendants of a vulval precursor cell exhibit altered developmental programs compared to their counterparts in control animals. In C. elegans, the VPCs are P3.p-P8.p. WB:WBPaper00005610 WB:WBPerson2021 The processes governing the expansion of blast cell populations vary, such that cell populations are decreased compared to control. C_elegans_phenotype_ontology WBPhenotype:0000240 blast cell proliferation reduced The processes governing the expansion of blast cell populations vary, such that cell populations are decreased compared to control. WB:WBPerson2021 Animals exhibit an increase in the quantity of cells that have undergone programmed cell death but have not been engulfed. C_elegans_phenotype_ontology WBPhenotype:0000241 accumulated cell corpses Animals exhibit an increase in the quantity of cells that have undergone programmed cell death but have not been engulfed. WB:WBPerson712 The epidermal cells of the embryo fail to elongate. In C. elegans, this elongation occurs along an anterior-posterior axis, which is required to transform the bean-shaped embryo into the elongated shape of the worm. C_elegans_phenotype_ontology WBPhenotype:0000242 body elongation defective The epidermal cells of the embryo fail to elongate. In C. elegans, this elongation occurs along an anterior-posterior axis, which is required to transform the bean-shaped embryo into the elongated shape of the worm. WB:WBPerson2021 Removal of cell corpses through a dedicated engulfment pathway is defective. C_elegans_phenotype_ontology corpse engulfment defective persistent cell corpses WBPhenotype:0000243 engulfment failure by killer cell Removal of cell corpses through a dedicated engulfment pathway is defective. WB:WBPerson712 Cells fail to complete the form of programmed cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), classically little or no ultrastructural modifications of cytoplasmic organelles, plasma membrane blebbing (but maintenance of its integrity until the final stages of the process) and engulfment by resident phagocytes. C_elegans_phenotype_ontology apoptosis block WBPhenotype:0000244 apoptotic arrest Cells fail to complete the form of programmed cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), classically little or no ultrastructural modifications of cytoplasmic organelles, plasma membrane blebbing (but maintenance of its integrity until the final stages of the process) and engulfment by resident phagocytes. WB:WBPerson712 Variations in the movement of sex myoblasts compared to control animals. In C. elegans, the larval SM migrate anteriorly to the precise center of the developing hermaphrodite gonad. SM migration abnormal C_elegans_phenotype_ontology WBPhenotype:0000245 SM migration variant Variations in the movement of sex myoblasts compared to control animals. In C. elegans, the larval SM migrate anteriorly to the precise center of the developing hermaphrodite gonad. WB:WBPaper00003627 WB:WBPerson2021 Animals exhibit variation in the time of onset of the defecation motor program significantly greater than that observed for control animals. C_elegans_phenotype_ontology WBPhenotype:0000246 defecation cycle variable length Animals exhibit variation in the time of onset of the defecation motor program significantly greater than that observed for control animals. WB:WBPaper00031896 WB:WBPerson712 Failure to execute the characteristic response to sodium as defined by control animals. In C. elegans, sodium is typically an attractant. C_elegans_phenotype_ontology Na chemotaxis defective sodium acetate chemotaxis defective WBPhenotype:0000247 sodium chemotaxis defective Failure to execute the characteristic response to sodium as defined by control animals. In C. elegans, sodium is typically an attractant. WB:cab WB:cgc387 sodium acetate chemotaxis defective WB:WBPerson2021 OBSOLETE. sensory neuroanatomy abnormal C_elegans_phenotype_ontology WBPhenotype:0000248 obsolete sensory neuroanatomy variant true OBSOLETE. WB:WBPerson557 Failure to execute the characteristic avoidance response to solutions of high osmotic strength as defined by control animals. C_elegans_phenotype_ontology WBPhenotype:0000249 osmotic avoidance defective Failure to execute the characteristic avoidance response to solutions of high osmotic strength as defined by control animals. WB:WBPerson2021 WB:cab Animals exhibit variations in any chemical reaction or pathway involving octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol, compared to control. octopamine metabolism abnormal C_elegans_phenotype_ontology WBPhenotype:0000250 octopamine metabolism variant Animals exhibit variations in any chemical reaction or pathway involving octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol, compared to control. GO:0046333 WB:WBPerson557 WB:WBPerson712 Animals do not contain or are unable to maintain a perceivable level of octopamine capable of initiating or maintaining dopamine-dependent cell activity. C_elegans_phenotype_ontology WBPhenotype:0000251 octopamine deficient Animals do not contain or are unable to maintain a perceivable level of octopamine capable of initiating or maintaining dopamine-dependent cell activity. WB:WBPerson712 Animals fail to respond to the concentration of caffeine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000252 caffeine resistant Animals fail to respond to the concentration of caffeine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 Animals exhibit a lack of consistency, regularity, or uniformity while traveling from one location to another. C_elegans_phenotype_ontology movement irregular WBPhenotype:0000253 movement erratic Animals exhibit a lack of consistency, regularity, or uniformity while traveling from one location to another. WB:WBPerson2021 WB:WBPerson557 Failure to execute the characteristic response to chloride. In C. elegans, chloride is typically an attractant. C_elegans_phenotype_ontology Cl chemotaxis defective WBPhenotype:0000254 chloride chemotaxis defective Failure to execute the characteristic response to chloride. In C. elegans, chloride is typically an attractant. WB:cab WB:cgc387 Animals exhibit variations in the quantity, structure or organization of the components of the neuronal cells of the amphid and phasmid sensilla from that observed in control animals. In C. elegans, these neurons are commonly assayed by dye-filling experiments using FITC, DiI or DiO. amphid phasmid morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000255 WBbt:0005394, WBbt:0006753. amphid phasmid neuron morphology variant Animals exhibit variations in the quantity, structure or organization of the components of the neuronal cells of the amphid and phasmid sensilla from that observed in control animals. In C. elegans, these neurons are commonly assayed by dye-filling experiments using FITC, DiI or DiO. WB:WBPaper00000938 Animals exhibit variations in the quantity, structure or organization of the components of the neuronal cells of the amphid sensillum, from that observed in control animals. In C. elegans, these neurons are commonly assayed by dye-filling experiments using FITC, DiI or DiO. amphid morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000256 WBbt:0005394. amphid neuron morphology variant Animals exhibit variations in the quantity, structure or organization of the components of the neuronal cells of the amphid sensillum, from that observed in control animals. In C. elegans, these neurons are commonly assayed by dye-filling experiments using FITC, DiI or DiO. WB:WBPaper00000938 Animals exhibit variations in the quantity, structure or organization of the components of the neuronal cells of the phasmid sensillum, from that observed in control animals. In C. elegans, these neurons are commonly assayed by dye-filling experiments using FITC, DiI or DiO. phasmid morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000257 WBbt:0006753. phasmid neuron morphology variant Animals exhibit variations in the quantity, structure or organization of the components of the neuronal cells of the phasmid sensillum, from that observed in control animals. In C. elegans, these neurons are commonly assayed by dye-filling experiments using FITC, DiI or DiO. WB:WBPaper00000938 Variations in the regulated release of substances by a cell compared to control. WBPhenotype:0000723 cellular secretion abnormal cell secretion abnormal C_elegans_phenotype_ontology WBPhenotype:0000258 cell secretion variant Variations in the regulated release of substances by a cell compared to control. GO:0032940 WB:WBPerson2021 Variations in the regulated release of substances by nonneuronal cells that enclose or ensheath the tips of the sensory dendrites compared to control. sheath cell secretion abnormal C_elegans_phenotype_ontology WBPhenotype:0000259 sheath cell secretion variant Variations in the regulated release of substances by nonneuronal cells that enclose or ensheath the tips of the sensory dendrites compared to control. WB:WBPaper00000822 WB:WBPerson2021 The regulated release of materials by sheath cells is disrupted. C_elegans_phenotype_ontology WBPhenotype:0000260 sheath cell secretion failure The regulated release of materials by sheath cells is disrupted. WB:WBPaper00028924 WB:WBPerson2021 Amphid sheath cells lack the ability to secrete vesicles and their contents within the amphid pocket. C_elegans_phenotype_ontology WBPhenotype:0000261 amphid sheath secretion failure Amphid sheath cells lack the ability to secrete vesicles and their contents within the amphid pocket. WB:WBPaper00028924 WB:WBPerson2021 Animals exhibit variations in the structure or composition of the microtubule-based fibrillar bundle (axoneme) that makes up the core of the middle part of the cilium (in a pattern of nine doublet microtubules attached to the membrane and a variable number of smaller singlet microtubules occupying the center). In C. elegans, the axoneme microtubules are arranged in a pattern of nine doublets attached to the membrane with seven smaller singlet microtubules occupying the center. axoneme morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000262 axoneme morphology variant Animals exhibit variations in the structure or composition of the microtubule-based fibrillar bundle (axoneme) that makes up the core of the middle part of the cilium (in a pattern of nine doublet microtubules attached to the membrane and a variable number of smaller singlet microtubules occupying the center). In C. elegans, the axoneme microtubules are arranged in a pattern of nine doublets attached to the membrane with seven smaller singlet microtubules occupying the center. WB:WBPaper00000932 WB:WBPerson557 WB:WBPerson712 The microbule-based fibrillar bundle in the core of the cilium is reduced in length compared to axonemes of similar cells in control animals. C_elegans_phenotype_ontology WBPhenotype:0000263 axoneme short The microbule-based fibrillar bundle in the core of the cilium is reduced in length compared to axonemes of similar cells in control animals. WB:WBPaper00000932 WB:WBPerson557 WB:WBPerson712 Failure to execute the characteristic response to cAMP as defined by control animals. In C. elegans, cAMP is typically an attractant. C_elegans_phenotype_ontology WBPhenotype:0000264 cAMP chemotaxis defective Failure to execute the characteristic response to cAMP as defined by control animals. In C. elegans, cAMP is typically an attractant. WB:WBPaper00001481 WB:WBPaper00002033 WB:cab WB:cgc387 Movement towards typically attractive volatile organic chemicals is altered as defined by control animals. In C. elegans, these odorants are typically sensed by the AWA and AWC neurons. odorant positive chemotaxis abnormal C_elegans_phenotype_ontology WBPhenotype:0000265 odorant positive chemotaxis variant Movement towards typically attractive volatile organic chemicals is altered as defined by control animals. In C. elegans, these odorants are typically sensed by the AWA and AWC neurons. WB:WBPerson2021 WB:cab WB:cgc1786 Variations that disrupt stereotypical cleavage patterns (such as cleavage rate, division axes or asymmetric division) compared to control. cell cleavage abnormal C_elegans_phenotype_ontology WBPhenotype:0000266 cell cleavage variant Variations that disrupt stereotypical cleavage patterns (such as cleavage rate, division axes or asymmetric division) compared to control. WB:WBPerson2021 WB:WBPerson557 Any variation that causes a delay in the stereotypical cleavage event compared to control. C_elegans_phenotype_ontology WBPhenotype:0000267 cell cleavage delayed Any variation that causes a delay in the stereotypical cleavage event compared to control. WB:WBPerson2021 WB:WBPerson557 Any variation that causes a delay in the stereotypical cleavage pattern of the P cell compared to control. C_elegans_phenotype_ontology WBPhenotype:0000268 P cell cleavage delayed Any variation that causes a delay in the stereotypical cleavage pattern of the P cell compared to control. WB:WBPerson2021 WB:WBPerson557 OBSOLETE. Animals display a phenotype that has not yet been assigned to a current classification. C_elegans_phenotype_ontology WBPhenotype:0000269 obsolete unclassified true OBSOLETE. Animals display a phenotype that has not yet been assigned to a current classification. WB:WBPerson2021 WB:WBPerson557 Seemingly unrelated variations that concurrently occur during early embryonic development compared to control animals. In C. elegans, this can include multiple pronuclei, aberrant cytoplasmic texture, decrease in overall pace of development and osmotic sensitivity. Emb C_elegans_phenotype_ontology WBPhenotype:0000270 pleiotropic defects severe early emb Seemingly unrelated variations that concurrently occur during early embryonic development compared to control animals. In C. elegans, this can include multiple pronuclei, aberrant cytoplasmic texture, decrease in overall pace of development and osmotic sensitivity. WB:cab WB:cgc7141 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000271 obsolete cell cycle slow true The rate of the intrinsic behavioral program that serves to move fertilized eggs down the uterus, through the vulva, and out of the worm onto the substrate does not conform to the pattern observed in control animals (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000272 egg laying irregular The rate of the intrinsic behavioral program that serves to move fertilized eggs down the uterus, through the vulva, and out of the worm onto the substrate does not conform to the pattern observed in control animals (Wormatlas). WB:WBPerson2021 WB:WBPerson557 The number of body thrashes within an aqueous environment in a given period of time are reduced compared with control worms. C_elegans_phenotype_ontology WBPhenotype:0000273 thrashing reduced The number of body thrashes within an aqueous environment in a given period of time are reduced compared with control worms. WB:cab WB:cgc7388 Animals lay eggs that are inviable. C_elegans_phenotype_ontology WBPhenotype:0000274 dead eggs laid Animals lay eggs that are inviable. WB:cab Organisms respond to UV at a lower dose or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000275 organism UV hypersensitive Organisms respond to UV at a lower dose or a shorter exposure compared to control animals. WB:WBPerson557 Animals exhibit variations in their response to X-ray radiation compared to that observed in control animals. organism X ray response abnormal C_elegans_phenotype_ontology WBPhenotype:0000276 organism X ray response variant Animals exhibit variations in their response to X-ray radiation compared to that observed in control animals. WB:WBPerson557 The timing of a biological cycle that recurs with regularity is delayed compared to control. C_elegans_phenotype_ontology WBPhenotype:0000277 rhythm slow The timing of a biological cycle that recurs with regularity is delayed compared to control. GO:0048511 WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency or translucency of a particular body region. body region pigmentation abnormal body region pigmentation variant C_elegans_phenotype_ontology WBPhenotype:0000278 body region pigmentation phenotype Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency or translucency of a particular body region. WB:WBPerson557 Males exhibit defects in the insertion of the male copulatory spicules into the mating partner. In C. elegan spicule insertion behavior initiates when the male cloaca contacts the vulva. During most mating encounters, the spicule tips will prod the vulva continuously until they partially penetrate, which then causes the protractors to contract completely so that the spicules extend through the vulva. C_elegans_phenotype_ontology WBPhenotype:0000279 spicule insertion defective Males exhibit defects in the insertion of the male copulatory spicules into the mating partner. In C. elegan spicule insertion behavior initiates when the male cloaca contacts the vulva. During most mating encounters, the spicule tips will prod the vulva continuously until they partially penetrate, which then causes the protractors to contract completely so that the spicules extend through the vulva. GO:0034609 WB:WBPerson2021 WB:WBPerson557 The small linear ridges running along the lateral lines of the cuticle, lengthwise along the body, contain gaps as opposed to a continuous arrangement (Wormatlas). gapped alae C_elegans_phenotype_ontology WBPhenotype:0000280 breaks in alae The small linear ridges running along the lateral lines of the cuticle, lengthwise along the body, contain gaps as opposed to a continuous arrangement (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Variations in the progression of the muscles of the adult male reproductive system over time form their initial formation to their mature structure compared to control. male sex muscle development abnormal C_elegans_phenotype_ontology WBPhenotype:0000281 male sex muscle development variant Variations in the progression of the muscles of the adult male reproductive system over time form their initial formation to their mature structure compared to control. WB:WBPerson2021 WB:WBPerson557 Variations in the progression of the muscles of the adult hermaphrodite reproductive system over time form their initial formation to their mature structure compared to control. hermaphrodite sex muscle development abnormal C_elegans_phenotype_ontology WBPhenotype:0000282 hermaphrodite sex muscle development variant Variations in the progression of the muscles of the adult hermaphrodite reproductive system over time form their initial formation to their mature structure compared to control. WB:WBPerson2021 WB:WBPerson557 Animals exhibit defects in the continuity of lumen between the vulva and uterus compared to control animals. AC block C_elegans_phenotype_ontology WBPhenotype:0000283 vulva uterus connection defective Animals exhibit defects in the continuity of lumen between the vulva and uterus compared to control animals. WB:WBPaper00003386 WB:WBPaper00006298 WB:WBPaper00027236 WB:WBPaper00027316 WB:WBPerson712 Any defect in the process whereby a male inseminates his partner by introducing sperm into the genital tract. C_elegans_phenotype_ontology WBPhenotype:0000284 sperm transfer defective Any defect in the process whereby a male inseminates his partner by introducing sperm into the genital tract. GO:0007320 WB:WBPerson2021 WB:WBPerson557 The extreme ends of any of the finger-like sensory sensilla that project from the tail and embed in the male fan appear bloated or distended. C_elegans_phenotype_ontology WBPhenotype:0000285 ray tips swollen The extreme ends of any of the finger-like sensory sensilla that project from the tail and embed in the male fan appear bloated or distended. WB:WBPerson2021 WB:WBPerson557 Embryos fail to be organized in the same manner as observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0000286 embryo disorganized Embryos fail to be organized in the same manner as observed in control animals. WB:WBPerson2021 WB:WBPerson557 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000287 obsolete vulval invagination L4 abnormal true Variations in the progression of the lineages that gives rise to all germ cells, lying in the region adjacent to the proximal gonad (on the side furthest from the founder cells of the somatic gonad), over time compared to control animals. distal germline abnormal C_elegans_phenotype_ontology distal germ line abnormal WBPhenotype:0000288 distal germline variant Variations in the progression of the lineages that gives rise to all germ cells, lying in the region adjacent to the proximal gonad (on the side furthest from the founder cells of the somatic gonad), over time compared to control animals. WB:WBPerson2021 WB:WBPerson557 Any variation in the form, structure or composition of the portion of the somatic gonad which encloses the fertilized eggs after their passage through the spermatheca compared to control (Wormatlas). uterus morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000289 uterus morphology variant Any variation in the form, structure or composition of the portion of the somatic gonad which encloses the fertilized eggs after their passage through the spermatheca compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Animals lack fully specialized male gametes that are competent for fertilization. C_elegans_phenotype_ontology no sperm WBPhenotype:0000290 sperm absent Animals lack fully specialized male gametes that are competent for fertilization. WB:WBPerson2021 Hermaphrodites lack fully specialized female gametes that are competent for fertilization. C_elegans_phenotype_ontology oocytes absent WBPhenotype:0000291 no oocytes Hermaphrodites lack fully specialized female gametes that are competent for fertilization. WB:WBPerson2021 Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of a organ system. organ system pigmentation abnormal organ system pigmentation variant C_elegans_phenotype_ontology WBPhenotype:0000292 organ system pigmentation phenotype Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of a organ system. WB:WBPerson557 Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of the alimentary system. alimentary system pigmentation abnormal C_elegans_phenotype_ontology WBPhenotype:0000293 alimentary system pigmentation variant Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of the alimentary system. WB:WBPerson557 Animals exhibit variations in the accumulation or expression of biochromes or any other substances that decrease the transparency/translucency of the intestine. Din C_elegans_phenotype_ontology WBPhenotype:0000294 intestine dark Animals exhibit variations in the accumulation or expression of biochromes or any other substances that decrease the transparency/translucency of the intestine. WB:WBPerson557 Animals are able to survive for longer periods at temperatures above standard culture temperatures than control animals. intrinsic thermotolerance increased C_elegans_phenotype_ontology WBPhenotype:0000295 thermotolerance increased Animals are able to survive for longer periods at temperatures above standard culture temperatures than control animals. WB:WBPaper00005836 WB:WBPerson712 The elongated sclerotized structures covered by a hardened layer of cuticle in the male tail (which are actively everted during copulation to fasten the male copulatory fan to the vulva) are deformed. In C. elegans males there are two copulatory spicules. C_elegans_phenotype_ontology WBPhenotype:0000296 spicules crumpled The elongated sclerotized structures covered by a hardened layer of cuticle in the male tail (which are actively everted during copulation to fasten the male copulatory fan to the vulva) are deformed. In C. elegans males there are two copulatory spicules. WB:WBPerson2021 WB:WBPerson557 Any of the finger-like sensory sensilla that project from the tail and embed in the male fan are joined to one another. WBPhenotype:0001241 ray fusion C_elegans_phenotype_ontology WBPhenotype:0000297 rays fused Any of the finger-like sensory sensilla that project from the tail and embed in the male fan are joined to one another. WB:WBPerson2021 WB:WBPerson557 Any of the finger-like sensory sensilla that project from the tail and embed in the male fan are shifted from their customary place. C_elegans_phenotype_ontology WBPhenotype:0000298 rays displaced Any of the finger-like sensory sensilla that project from the tail and embed in the male fan are shifted from their customary place. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the quantity, structure or organization of the components of the sense organs comprised of ciliated sensory nerve endings enveloped by sheath and/or socket cells, from that observed in control animals. sensillum morphology abnormal C_elegans_phenotype_ontology chemosensory cell morphology abnormal WBPhenotype:0000299 sensillum morphology variant Animals exhibit variations in the quantity, structure or organization of the components of the sense organs comprised of ciliated sensory nerve endings enveloped by sheath and/or socket cells, from that observed in control animals. WB:WBPaper00000214 WB:WBPaper00000938 WB:WBPerson712 Animals exhibit variations in the structure or composition of the amphid sensillum cell that ensheathes the dendrite tips of channel neurons and wing cell dedritic processes, from that observed in control animals. Sheath cells in C.elegans have highly invaginated and vesiculated surfaces, which provide a specialized environment for the dendritic structures. amphid sheath cell morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000300 amphid sheath cell morphology variant Animals exhibit variations in the structure or composition of the amphid sensillum cell that ensheathes the dendrite tips of channel neurons and wing cell dedritic processes, from that observed in control animals. Sheath cells in C.elegans have highly invaginated and vesiculated surfaces, which provide a specialized environment for the dendritic structures. WB:WBPaper00000214 WB:WBPaper00000503 WB:WBPaper00000822 WB:WBPerson712 A migrating distal tip cell (DTC) fails to follow the stereotypical path. In C. elegans this path is U-shaped and results in the formation of reflexed gonadal arm. C_elegans_phenotype_ontology WBPhenotype:0000301 distal tip cell reflex failure A migrating distal tip cell (DTC) fails to follow the stereotypical path. In C. elegans this path is U-shaped and results in the formation of reflexed gonadal arm. WB:WBPaper00029151 WB:WBPerson2021 Failure to execute the characteristic response to benzaldehyde as defined by control animals. In C.elegans benzaldehyde is typically attractive. C_elegans_phenotype_ontology WBPhenotype:0000302 benzaldehyde chemotaxis defective Failure to execute the characteristic response to benzaldehyde as defined by control animals. In C.elegans benzaldehyde is typically attractive. WB:WBPaper00001786 Failure to execute the characteristic response to diacetyl as defined by control animals. In C.elegans diacetyl is typically attractive. C_elegans_phenotype_ontology WBPhenotype:0000303 diacetyl chemotaxis defective Failure to execute the characteristic response to diacetyl as defined by control animals. In C.elegans diacetyl is typically attractive. WB:WBPaper00001786 Failure to execute the characteristic response to isoamyl alcohol as defined by control animals. In C.elegans isoamyl alcohol is typically attractive. C_elegans_phenotype_ontology WBPhenotype:0000304 isoamyl alcohol chemotaxis defective Failure to execute the characteristic response to isoamyl alcohol as defined by control animals. In C.elegans isoamyl alcohol is typically attractive. WB:cab WB:cgc1786 Animals exhibit variations in any of a series of events in which a pheromone stimulus is received by a cell and converted into a molecular signal that influences behavior in control animals. pheromone sensation abnormal C_elegans_phenotype_ontology WBPhenotype:0000305 pheromone sensation variant Animals exhibit variations in any of a series of events in which a pheromone stimulus is received by a cell and converted into a molecular signal that influences behavior in control animals. GO:0043695 WB:WBPerson2021 WB:WBPerson557 Any variation in the characteristic expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to control animals. transgene expression abnormal C_elegans_phenotype_ontology WBPhenotype:0000306 transgene expression variant Any variation in the characteristic expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to control animals. WB:WBPerson557 Animals fail to detect a pheromone stimulus that induces dauer formation in control animals. C_elegans_phenotype_ontology WBPhenotype:0000307 dauer pheromone sensation defective Animals fail to detect a pheromone stimulus that induces dauer formation in control animals. WB:WBPerson2021 WB:WBPerson557 Any variation in the processes that govern development of the dauer larva, a developmentally arrested, larval stage that is specialized for survival under harsh, or otherwise unfavorable, environmental conditions. In C. elegans this is an alternative third larval stage. WBPhenotype:0000159 dauer development abnormal dauer development variant C_elegans_phenotype_ontology dauer arrest abnormal dauer arrest variant diapause variant WBPhenotype:0000308 dauer development phenotype Any variation in the processes that govern development of the dauer larva, a developmentally arrested, larval stage that is specialized for survival under harsh, or otherwise unfavorable, environmental conditions. In C. elegans this is an alternative third larval stage. WB:kmva Any variation that decreases the ability of dauer larva to tolerate the exposure to sodium dodecyl sulfate (a detergent) compared to control. C_elegans_phenotype_ontology WBPhenotype:0000309 SDS sensitive dauer Any variation that decreases the ability of dauer larva to tolerate the exposure to sodium dodecyl sulfate (a detergent) compared to control. WB:WBPerson2021 Neurons lack the finger-like dendritic projections, which are observed extending from similar cells in control animals. C_elegans_phenotype_ontology WBPhenotype:0000310 cilia absent Neurons lack the finger-like dendritic projections, which are observed extending from similar cells in control animals. WB:WBPaper00000932 WB:WBPerson712 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000311 obsolete semi sterile true Animals are incapable of synthesizing pheromones that induce dauer formation in control animals. C_elegans_phenotype_ontology WBPhenotype:0000312 dauer pheromone production defective Animals are incapable of synthesizing pheromones that induce dauer formation in control animals. GO:0042446 WB:WBPerson2021 Developing oocytes show defects in their initial entry or progression through the meiotic pathway (such as failure to exit diakinesis). meiotic progression during oogenesis abnormal C_elegans_phenotype_ontology WBPhenotype:0000313 meiotic progression during oogenesis variant Developing oocytes show defects in their initial entry or progression through the meiotic pathway (such as failure to exit diakinesis). WB:WBPaper00026997 WB:WBPerson2021 Animals are slight or meager in body size compared to control animals at the same developmental stage. C_elegans_phenotype_ontology WBPhenotype:0000314 scrawny Animals are slight or meager in body size compared to control animals at the same developmental stage. WB:WBPerson2021 WB:WBPerson557 Any variation with respect to perception or response to mechanical stimuli compared to control animals. WBPhenotype:0000513 Mec touch response abnormal mechanosensation abnormal C_elegans_phenotype_ontology WBPhenotype:0000315 mechanosensation variant Any variation with respect to perception or response to mechanical stimuli compared to control animals. WB:cab Failure to execute a characteristic response when struck or stroked in the posterior region. In C. elegans, animals move forward movement when struck or stroked in the posterior region, usually with a hair or similar fiber. The posterior region lies between the vulva and the tail. touch resistant posterior body C_elegans_phenotype_ontology touch insensitive tail WBPhenotype:0000316 touch resistant tail Failure to execute a characteristic response when struck or stroked in the posterior region. In C. elegans, animals move forward movement when struck or stroked in the posterior region, usually with a hair or similar fiber. The posterior region lies between the vulva and the tail. WB:WBPaper00000502 WB:WBPaper00001133 WB:WBPaper00001705 WB:WBPerson557 Animals are deficient in the foraging response in which an animal quickly pulls its head away from a stimulus to the nose (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000317 head withdrawal defective Animals are deficient in the foraging response in which an animal quickly pulls its head away from a stimulus to the nose (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Cells of the animals proceed through their replicative phase at a pace slower than observed for control cells. C_elegans_phenotype_ontology WBPhenotype:0000318 cell cycle delayed Cells of the animals proceed through their replicative phase at a pace slower than observed for control cells. WB:WBPerson712 Animals have increased girth and increased length compared to control animals at the same developmental stage. body size enlarged C_elegans_phenotype_ontology WBPhenotype:0000319 large Animals have increased girth and increased length compared to control animals at the same developmental stage. WB:WBPerson2021 WB:WBPerson557 Animals show a decrease in survivorship after thawing compared to control. C_elegans_phenotype_ontology WBPhenotype:0000320 reduced viability after freezing Animals show a decrease in survivorship after thawing compared to control. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the form, structure or composition of any portion of the extreme anterior part of their body compared to control. nose morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000321 nose morphology variant Animals exhibit variations in the form, structure or composition of any portion of the extreme anterior part of their body compared to control. WB:WBPerson2021 WB:WBPerson557 The extreme anterior part of the body appears blunted in shape. C_elegans_phenotype_ontology WBPhenotype:0000322 nose rounded The extreme anterior part of the body appears blunted in shape. WB:WBPerson2021 WB:WBPerson557 The most anterior portion of the animal appears bloated or distended. C_elegans_phenotype_ontology WBPhenotype:0000323 head swollen The most anterior portion of the animal appears bloated or distended. WB:WBPerson2021 WB:WBPerson557 Animals exhibit a decreased body length compared to control animals of the same developmental stage. C_elegans_phenotype_ontology WBPhenotype:0000324 short Animals exhibit a decreased body length compared to control animals of the same developmental stage. WB:WBPerson712 Animals respond to arecoline at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000325 arecoline hypersensitive Animals respond to arecoline at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 Animals fail to respond to the concentration of arecoline that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000326 arecoline resistant Animals fail to respond to the concentration of arecoline that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 Any defect in the muscle contractions of the extended anterior region of the pharynx lying just anterior to the isthmus and terminal bulb (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000327 corpus contraction defect Any defect in the muscle contractions of the extended anterior region of the pharynx lying just anterior to the isthmus and terminal bulb (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Variations in the rhythmic contractions of the posterior pharynx (terminal bulb), such as timing, strength etc. In C. elegans contraction of the terminal bulb inverts the grinder, allowing bacteria in front of the grinder to be broken up and transported to the intestine. terminal bulb contraction abnormal C_elegans_phenotype_ontology WBPhenotype:0000328 terminal bulb contraction variant Variations in the rhythmic contractions of the posterior pharynx (terminal bulb), such as timing, strength etc. In C. elegans contraction of the terminal bulb inverts the grinder, allowing bacteria in front of the grinder to be broken up and transported to the intestine. WB:WBPaper00001696 The rhythmic contractions of pharyngeal compartments are no longer synchronized compared to control. In C. elegans the corpus and terminal bulb normally contract simultaneously. C_elegans_phenotype_ontology WBPhenotype:0000329 pumping asynchronous The rhythmic contractions of pharyngeal compartments are no longer synchronized compared to control. In C. elegans the corpus and terminal bulb normally contract simultaneously. WB:WBPaper00001696 Defects in rhythmic pharyngeal relaxations compared to control animals. In C. elegans pharyngeal relaxation follows a contraction event and facilitates bacterial trapping within the pharynx while expelling liquid. C_elegans_phenotype_ontology WBPhenotype:0000330 pharyngeal relaxation defective Defects in rhythmic pharyngeal relaxations compared to control animals. In C. elegans pharyngeal relaxation follows a contraction event and facilitates bacterial trapping within the pharynx while expelling liquid. WB:WBPaper00001709 Animals fail to respond to the concentration of sodium potassium ATPase antagonists that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. ouabain resistant C_elegans_phenotype_ontology WBPhenotype:0000331 inhibitors of na k atpase resistant Animals fail to respond to the concentration of sodium potassium ATPase antagonists that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson2021 Animals respond to inhibitors of sodium potassium ATPase at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000332 inhibitors of sodium potassium ATPase hypersensitive Animals respond to inhibitors of sodium potassium ATPase at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 The time interval of the stereotyped sequence of muscle contractions by individual pharyngeal muscles that act to draw food into the pharynx is shorter compared to that observed in control (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000333 pharyngeal pumps brief The time interval of the stereotyped sequence of muscle contractions by individual pharyngeal muscles that act to draw food into the pharynx is shorter compared to that observed in control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Failure of muscle contractions in the corpus and isthmus to trap and transport bacteria posteriorly in the pharynx. C_elegans_phenotype_ontology WBPhenotype:0000334 isthmus corpus slippery Failure of muscle contractions in the corpus and isthmus to trap and transport bacteria posteriorly in the pharynx. WB:WBPaper00001696 Failure of pharyngeal contractions to trap and transport bacteria posteriorly. In C. elegans this defect results in a distention of the pharyngeal lumen. C_elegans_phenotype_ontology WBPhenotype:0000335 pharynx slippery Failure of pharyngeal contractions to trap and transport bacteria posteriorly. In C. elegans this defect results in a distention of the pharyngeal lumen. WB:WBPaper00001696 Variations in the rhythmic relaxations of the posterior pharynx (terminal bulb). In C. elegans the relaxation of the terminal bulb returns the grinder to its relaxed forward position. terminal bulb relaxation abnormal C_elegans_phenotype_ontology WBPhenotype:0000336 terminal bulb relaxation variant Variations in the rhythmic relaxations of the posterior pharynx (terminal bulb). In C. elegans the relaxation of the terminal bulb returns the grinder to its relaxed forward position. WB:WBPaper00001696 Failure of the grinder to come to a full relaxed position between pumps compared to control. C_elegans_phenotype_ontology WBPhenotype:0000337 grinder relaxation defective Failure of the grinder to come to a full relaxed position between pumps compared to control. WB:WBPaper00001709 Swelling in the post anal region compared to control. In C. elegans this swelling can be associated with infection from the nematode-specific bacterial pathogen, Microbacterium nematophilum. Dar C_elegans_phenotype_ontology deformed anal region WBPhenotype:0000338 tail swelling Swelling in the post anal region compared to control. In C. elegans this swelling can be associated with infection from the nematode-specific bacterial pathogen, Microbacterium nematophilum. WB:WBPaper00026735 WB:cab Worms sporatically appear turgid or swollen as a result of an excess number of eggs being retained in the uterus. C_elegans_phenotype_ontology WBPhenotype:0000339 transient bloating Worms sporatically appear turgid or swollen as a result of an excess number of eggs being retained in the uterus. WB:WBPerson2021 WB:WBPerson557 Animals fail to respond to the concentration of imipramine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000340 imipramine resistant Animals fail to respond to the concentration of imipramine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 Animals respond to imipramine at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000341 imipramine hypersensitive Animals respond to imipramine at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 Any variation in the form, structure or composition of the adult male tail including the lateral fan and rays compared to control. bursa morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000342 bursa morphology variant Any variation in the form, structure or composition of the adult male tail including the lateral fan and rays compared to control. WB:WBPerson2021 WB:WBPerson557 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000343 obsolete cloaca morphology abnormal true Any of the contents that comprise the epithelial chamber that links the genital and alimentary tracts to the exterior via the anus extend into the external environment through the cloacal opening. C_elegans_phenotype_ontology WBPhenotype:0000344 cloacal structures protrude Any of the contents that comprise the epithelial chamber that links the genital and alimentary tracts to the exterior via the anus extend into the external environment through the cloacal opening. WB:WBPerson2021 WB:WBPerson557 Any variation that alters the physical partitioning and separation of a vulval precursor cell into daughter cells compared to control. VPC cell division abnormal C_elegans_phenotype_ontology WBPhenotype:0000345 VPC cell division variant Any variation that alters the physical partitioning and separation of a vulval precursor cell into daughter cells compared to control. WB:WBPerson2021 WB:WBPerson557 Adult animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter its transparency/translucency compared to control animals. adult pigmentation abnormal C_elegans_phenotype_ontology WBPhenotype:0000346 adult pigmentation variant Adult animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter its transparency/translucency compared to control animals. WB:WBPerson557 Any variation in the progression of the cuticle-lined sinus opening on the posterior ventral surface of the animal over time from its formation to its mature structure compared to control (Wormatlas). The function of the rectum is to excrete waste products from the alimentary system. rectal development abnormal C_elegans_phenotype_ontology WBPhenotype:0000347 rectal development variant Any variation in the progression of the cuticle-lined sinus opening on the posterior ventral surface of the animal over time from its formation to its mature structure compared to control (Wormatlas). The function of the rectum is to excrete waste products from the alimentary system. WB:WBPerson2021 WB:WBPerson557 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000348 obsolete muscle activation defective true A semi-paralysed body phenotype in which muscle tone is lost and the animal fails to actively control its body shape (Wormatlas). C_elegans_phenotype_ontology floppy limp WBPhenotype:0000349 flaccid A semi-paralysed body phenotype in which muscle tone is lost and the animal fails to actively control its body shape (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the structure or appearance of the thin cuticle specialization found at the extreme posterior end of the hermaphrodite tail compared to control. C_elegans_phenotype_ontology WBPhenotype:0000350 hermaphrodite tail spike variant Any variation in the structure or appearance of the thin cuticle specialization found at the extreme posterior end of the hermaphrodite tail compared to control. WB:WBPerson2021 WB:WBPerson557 Animals fail to emerge from an egg shell. C_elegans_phenotype_ontology WBPhenotype:0000351 failure to hatch Animals fail to emerge from an egg shell. GO:0035188 WB:WBPerson2021 Backward movement is not coordinated as in control. This often causes jerky or spastic backward locomotion. C_elegans_phenotype_ontology WBPhenotype:0000352 backing uncoordinated Backward movement is not coordinated as in control. This often causes jerky or spastic backward locomotion. WB:WBPaper00001709 Animals spend more time backing compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000353 backing increased Animals spend more time backing compared to control animals. WB:cab Variations in the processes leading to the specialization of cell. Differentiation impacts diverse cellular properties such as size, shape, polarity, gene expression and responsiveness to signals/cues. cell differentiation abnormal C_elegans_phenotype_ontology WBPhenotype:0000354 cell differentiation variant Variations in the processes leading to the specialization of cell. Differentiation impacts diverse cellular properties such as size, shape, polarity, gene expression and responsiveness to signals/cues. WB:WBPerson2021 Specialization of HSN precursor cells to mature HSN neurons occurs at an earlier stage of development compared to control. C_elegans_phenotype_ontology WBPhenotype:0000355 HSN differentiation precocious Specialization of HSN precursor cells to mature HSN neurons occurs at an earlier stage of development compared to control. WB:WBPerson2021 The progression of immature germ cells to functional sperm is retarded compared to control. C_elegans_phenotype_ontology WBPhenotype:0000356 spermatogenesis delayed The progression of immature germ cells to functional sperm is retarded compared to control. WB:WBPaper00005566 WB:WBPerson2021 Animals lay inactivated oocytes. In C elegans this may be due to perturbations that eliminate spermatogenesis or result in the production of defective sperm. C_elegans_phenotype_ontology WBPhenotype:0000357 unfertilized oocytes laid Animals lay inactivated oocytes. In C elegans this may be due to perturbations that eliminate spermatogenesis or result in the production of defective sperm. WB:WBPaper00001075 WB:WBPerson2021 Animals execute supernumerary cell divisions post-hatching. C_elegans_phenotype_ontology supernumerary cell divisions WBPhenotype:0000358 extra cell division postembryonic Animals execute supernumerary cell divisions post-hatching. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the response to the addition of tunicamycin compared to that observed in control animals. Tunicamycin induces the unfolded protein response. tunicamycin response abnormal C_elegans_phenotype_ontology WBPhenotype:0000359 tunicamycin response variant Animals exhibit variations in the response to the addition of tunicamycin compared to that observed in control animals. Tunicamycin induces the unfolded protein response. WB:WBPaper00030877 WB:WBperson557 The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, or within the cytoplasm of a cell is impaired. C_elegans_phenotype_ontology WBPhenotype:0000360 Possible XP. cytoplasmic streaming defective The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, or within the cytoplasm of a cell is impaired. GO:0099636 WB:WBPaper00050908 WB:WBPerson2021 WB:WBPerson557 Cessation of development at an intermediate stage in embryogenesis, immediately following the completion of gastrulation. In C. elegans this occurs around 350-390 minutes after first cleavage, cell number is at approximately 560 cells. At this time cell proliferation ceases and the embryo begins morphogenesis and elongation. The shape of the entire embryo within the eggshell resembles a lima bean (Wormatlas). Emb C_elegans_phenotype_ontology arrest during epiboly WBPhenotype:0000361 lima bean arrest Cessation of development at an intermediate stage in embryogenesis, immediately following the completion of gastrulation. In C. elegans this occurs around 350-390 minutes after first cleavage, cell number is at approximately 560 cells. At this time cell proliferation ceases and the embryo begins morphogenesis and elongation. The shape of the entire embryo within the eggshell resembles a lima bean (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of the fluid-filled compartment inside the developing embryo at the onset of gastrulation over time from its formation to its mature structure compared to control (Wormatlas). blastocoel abnormal C_elegans_phenotype_ontology WBPhenotype:0000362 blastocoel variant Any variation in the progression of the fluid-filled compartment inside the developing embryo at the onset of gastrulation over time from its formation to its mature structure compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation that delays the physical partitioning and separation of a cell into daughter cells compared to control. C_elegans_phenotype_ontology WBPhenotype:0000363 cell division slow Any variation that delays the physical partitioning and separation of a cell into daughter cells compared to control. WB:WBPerson2021 WB:WBPerson557 The birefringent inclusions typically found in the intestinal cytoplasm accumulate extracellularly in the intestinal lumen. C_elegans_phenotype_ontology WBPhenotype:0000364 gut granule birefringence misplaced The birefringent inclusions typically found in the intestinal cytoplasm accumulate extracellularly in the intestinal lumen. WB:WBPaper00025094 Variations in the ability of an embryo to maintain osmotic balance. In C.elegans this can result in an embryo filling the egg shell and lysing. Emb Eos C_elegans_phenotype_ontology WBPhenotype:0000365 embryo osmotic integrity defective early emb Variations in the ability of an embryo to maintain osmotic balance. In C.elegans this can result in an embryo filling the egg shell and lysing. WB:cab WB:cgc7141 Cessation of development that normally occurs in C. elegans 520-620min after the first cleavage at 20C, the stage between the 2-fold and fully elongated embryo. Emb C_elegans_phenotype_ontology active elongation arrest WBPhenotype:0000366 three fold arrest Cessation of development that normally occurs in C. elegans 520-620min after the first cleavage at 20C, the stage between the 2-fold and fully elongated embryo. WB:WBPerson101 Cessation of development during the middle stage in embryogenesis of the worm in which the embryo is slightly folded within the eggshell (Wormatlas). Emb C_elegans_phenotype_ontology end of epiboly arrest WBPhenotype:0000367 comma arrest emb Cessation of development during the middle stage in embryogenesis of the worm in which the embryo is slightly folded within the eggshell (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Cessation of development that normally occurs in C. elegans 420-460 min after the first embryonic cleavage at 20C, the stage between the comma and 2-fold embryo. Emb C_elegans_phenotype_ontology arrest beginning elongation WBPhenotype:0000368 one point five fold arrest emb Cessation of development that normally occurs in C. elegans 420-460 min after the first embryonic cleavage at 20C, the stage between the comma and 2-fold embryo. WB:WBPerson101 Cessation of development during the final two stages in embryogenesis, 'early pretzel' stage and 'late pretzel' stage, just prior to hatching. The animal now is folded into four lengths within the eggshell and resembles a pretzel. By early pretzel stage, the head begins to move independently from the body (Wormatlas). Emb C_elegans_phenotype_ontology end of elongation arrest WBPhenotype:0000369 pretzel arrest Cessation of development during the final two stages in embryogenesis, 'early pretzel' stage and 'late pretzel' stage, just prior to hatching. The animal now is folded into four lengths within the eggshell and resembles a pretzel. By early pretzel stage, the head begins to move independently from the body (Wormatlas). WB:WBPerson2021 WB:WBPerson557 The fertilized oocytes have a greater than standard length measured end to end compared to control. C_elegans_phenotype_ontology WBPhenotype:0000370 egg long The fertilized oocytes have a greater than standard length measured end to end compared to control. WB:WBPerson2021 WB:WBPerson557 The physical partitioning and separation of a cell into daughter cells is interupted. C_elegans_phenotype_ontology WBPhenotype:0000371 cell division incomplete The physical partitioning and separation of a cell into daughter cells is interupted. WB:WBPerson2021 WB:WBPerson557 Animals lack the two small cells produced, each during one of the two meiotic cell divisions (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000372 no polar body formation Animals lack the two small cells produced, each during one of the two meiotic cell divisions (Wormatlas). WB:WBPerson2021 WB:WBPerson557 The overall structure or appearance of fertilized oocytes that are laid exhibit nonconsistent and significant deviation from that of control animals. C_elegans_phenotype_ontology WBPhenotype:0000373 egg shape variable The overall structure or appearance of fertilized oocytes that are laid exhibit nonconsistent and significant deviation from that of control animals. WB:WBPerson2021 WB:WBPerson557 The time interval in which early embryonic cell divisions occur is increased compared to control. C_elegans_phenotype_ontology WBPhenotype:0000374 early divisions prolonged The time interval in which early embryonic cell divisions occur is increased compared to control. WB:WBPerson2021 WB:WBPerson557 The time interval in which late embryonic cell divisions occur is increased compared to control. C_elegans_phenotype_ontology WBPhenotype:0000375 later divisions prolonged The time interval in which late embryonic cell divisions occur is increased compared to control. WB:WBPerson2021 WB:WBPerson557 Animals lack the inner space of the uterus through which the fertilized egg passes on its way out of the nematode via the vulva (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000376 no uterine cavity Animals lack the inner space of the uterus through which the fertilized egg passes on its way out of the nematode via the vulva (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the form, structure or composition of the internal space of the excretory canal compared to control animals. canal lumen morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000377 canal lumen morphology variant Animals exhibit variations in the form, structure or composition of the internal space of the excretory canal compared to control animals. WB:WBPerson2021 WB:WBPerson557 Pharyngeal muscle contractions show less displacement than that observed in control animals. C_elegans_phenotype_ontology WBPhenotype:0000378 pharyngeal pumping shallow Pharyngeal muscle contractions show less displacement than that observed in control animals. WB:WBPerson2021 WB:WBPerson557 The most anterior portion of the animal contains a V-shaped indentation. C_elegans_phenotype_ontology WBPhenotype:0000379 head notched The most anterior portion of the animal contains a V-shaped indentation. WB:WBPaper00000031 The final step of the defecation motor program does not occur at each cycle, but is activated occasionally. During this step in C. elegans specialized enteric muscles contract to expel the contents of the gut through the anus. C_elegans_phenotype_ontology WBPhenotype:0000380 expulsion infrequent The final step of the defecation motor program does not occur at each cycle, but is activated occasionally. During this step in C. elegans specialized enteric muscles contract to expel the contents of the gut through the anus. WB:WBPaper00002315 WB:WBPerson712 Animals fail to respond to the concentration of serotonin reuptake inhibitors that elicit a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000381 serotonin reuptake inhibitor resistant Animals fail to respond to the concentration of serotonin reuptake inhibitors that elicit a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 Animals respond to serotonin reuptake inhibitors at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000382 serotonin reuptake inhibitor hypersensitive Animals respond to serotonin reuptake inhibitors at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 The de novo synthesis of any lipid species is reduced compared to that observed in control animals. C_elegans_phenotype_ontology lipid synthesis decreased WBPhenotype:0000383 lipid synthesis defective The de novo synthesis of any lipid species is reduced compared to that observed in control animals. WB:WBPerson712 Variations in the cue-directed extension of an axon towards a specific target site compared to control. (Axon guidance often depends on a combination of attractive and repulsive cues). axon guidance abnormal C_elegans_phenotype_ontology axon pathfinding abnormal WBPhenotype:0000384 axon guidance variant Variations in the cue-directed extension of an axon towards a specific target site compared to control. (Axon guidance often depends on a combination of attractive and repulsive cues). GO:0048846 WB:WBPerson2021 Animals produce an increased sperm population compared to control. C_elegans_phenotype_ontology WBPhenotype:0000385 sperm excess Animals produce an increased sperm population compared to control. WB:WBPerson2021 Programmed cell death of germ cells caused by exposure to DNA-damaging chemical agents does not occur to the same extent as it does in control animals. genotoxic induced apoptosis abnormal C_elegans_phenotype_ontology DNA damage induced apoptosis abnormal WBPhenotype:0000386 genotoxic chemical induced apoptosis variant Programmed cell death of germ cells caused by exposure to DNA-damaging chemical agents does not occur to the same extent as it does in control animals. WB:WBPaper00032006 WB:WBPaper00032243 WB:WBPaper00032356 WB:WBPerson712 The mature male gametes lack self-propelled movement. C_elegans_phenotype_ontology WBPhenotype:0000387 sperm nonmotile The mature male gametes lack self-propelled movement. GO:0030317 WB:WBPerson2021 WB:WBPerson557 Any variation in the form, structure or composition of the mature male gamete, which merges with an oocyte to create a fertilized embryo copared to control (Wormatlas). sperm morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000388 sperm morphology variant Any variation in the form, structure or composition of the mature male gamete, which merges with an oocyte to create a fertilized embryo copared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any perturbation that renders hermaphrodite derived sperm incompetent at fertilizing an oocyte. Fer Spe C_elegans_phenotype_ontology WBPhenotype:0000389 hermaphrodite sperm fertilization defective Any perturbation that renders hermaphrodite derived sperm incompetent at fertilizing an oocyte. WB:WBPaper00001075 WB:WBPerson2021 Spermatids fail to mature into active sperm. In C. elegans round sessile spermatids mature into spermatozoa (polarized cells with a motile pseudopod), upon copulation or treatment with proteases. C_elegans_phenotype_ontology spermiogenesis defective WBPhenotype:0000390 spermatid activation defective Spermatids fail to mature into active sperm. In C. elegans round sessile spermatids mature into spermatozoa (polarized cells with a motile pseudopod), upon copulation or treatment with proteases. WB:WBPaper00000884 WB:WBPaper00027300 WB:WBPerson2021 Animals lack one or more of the stereotyped muscle contractions that result in defecation compared to control. In C. elegans these contractions include posterior body contraction (pBoc), anterior body contraction (aBoc), expulsion of gut contents by enteric muscle contraction (Emc) and opening of anus (Exp). C_elegans_phenotype_ontology WBPhenotype:0000391 defecation missing motor steps Animals lack one or more of the stereotyped muscle contractions that result in defecation compared to control. In C. elegans these contractions include posterior body contraction (pBoc), anterior body contraction (aBoc), expulsion of gut contents by enteric muscle contraction (Emc) and opening of anus (Exp). WB:WBPerson2021 WB:WBPerson557 Animals exhibit an increase in the accumulation or expression of biochromes or any other substances that fluoresce in the intestine. C_elegans_phenotype_ontology WBPhenotype:0000392 intestinal fluorescence increased Animals exhibit an increase in the accumulation or expression of biochromes or any other substances that fluoresce in the intestine. WB:WBPerson557 Characteristic movement of cells from one site to another is abolished compared to control. C_elegans_phenotype_ontology WBPhenotype:0000393 cell migration failure Characteristic movement of cells from one site to another is abolished compared to control. WB:WBPerson2021 Any variation in the movement of a protein through a gel matrix when an electric field is applied compared to control. C_elegans_phenotype_ontology WBPhenotype:0000394 electrophoretic variant protein Any variation in the movement of a protein through a gel matrix when an electric field is applied compared to control. WB:WBPerson2021 WB:WBPerson557 Animals are agametic (lack mature germ cells). C_elegans_phenotype_ontology WBPhenotype:0000395 no differentiated gametes Animals are agametic (lack mature germ cells). WB:WBPerson2021 Gonadal arms do not bend or curve. In C. elegans gonad arms normally reflex to form a stereotypical U-shaped pattern. C_elegans_phenotype_ontology WBPhenotype:0000396 non reflexed gonad arms Gonadal arms do not bend or curve. In C. elegans gonad arms normally reflex to form a stereotypical U-shaped pattern. WB:WBPaper00005086 WB:WBPaper00029151 WB:WBPerson2021 Animals do not respond to prodding with a fine platinum wire or similar tool compared to controls. C_elegans_phenotype_ontology harsh body touch insensitive WBPhenotype:0000397 harsh body touch resistant Animals do not respond to prodding with a fine platinum wire or similar tool compared to controls. WB:WBPaper00000502 Animals do not respond to stroking to the head or tail with a hair or similar fiber, but does respond to stronger mechanical stimuli such as prodding with a fine platinum wire or similar tool compared to controls. C_elegans_phenotype_ontology light body touch insensitive WBPhenotype:0000398 light body touch resistant Animals do not respond to stroking to the head or tail with a hair or similar fiber, but does respond to stronger mechanical stimuli such as prodding with a fine platinum wire or similar tool compared to controls. WB:WBPaper00000502 Any variation in the progression of the components of the gonad that are separate from the germline proper over time from its formation to its mature structure compared to control (Wormatlas). somatic gonad development abnormal C_elegans_phenotype_ontology WBPhenotype:0000399 somatic gonad development variant Any variation in the progression of the components of the gonad that are separate from the germline proper over time from its formation to its mature structure compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 The developmental progression of the set of precursor cells that later give rise to the somatic tissues of the gonadal tract is impaired (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000400 somatic gonad primordium development defective The developmental progression of the set of precursor cells that later give rise to the somatic tissues of the gonadal tract is impaired (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Animals lack the portion of the somatic gonad which encloses the fertilized eggs after their passage through the spermatheca (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000401 no uterus Animals lack the portion of the somatic gonad which encloses the fertilized eggs after their passage through the spermatheca (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Lawn avoidance refers to behavior in which animals initially enter the bacterial lawn but later exit and remain near the edge of the bacteria. Lawn avoidance is often a response to bacterial food, that is pathogenic or low quality to the animal. C_elegans_phenotype_ontology WBPhenotype:0000402 avoids bacterial lawn Lawn avoidance refers to behavior in which animals initially enter the bacterial lawn but later exit and remain near the edge of the bacteria. Lawn avoidance is often a response to bacterial food, that is pathogenic or low quality to the animal. WB:WBPaper00029071 WB:WBPerson2021 Any defect in the movement of sperm out of the seminal vesicle and into the vas deferens following tonic insertion of spicules into the mating partner compared to control. C_elegans_phenotype_ontology WBPhenotype:0000403 sperm transfer initiation defective Any defect in the movement of sperm out of the seminal vesicle and into the vas deferens following tonic insertion of spicules into the mating partner compared to control. WB:WBPaper00028400 The emergence of larvae from their protective egg shells is retarded compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000404 delayed hatching The emergence of larvae from their protective egg shells is retarded compared to control animals. GO:0035188 WB:WBPerson2021 The size of haploid female germ cells (oocytes) are significantly larger compared to control. C_elegans_phenotype_ontology oocytes large WBPhenotype:0000405 giant oocytes The size of haploid female germ cells (oocytes) are significantly larger compared to control. WB:WBPerson2021 WB:WBPerson557 Animals have protrusions or bumps on their exterior which are not characteristic of control animals. Lpy C_elegans_phenotype_ontology WBPhenotype:0000406 lumpy Animals have protrusions or bumps on their exterior which are not characteristic of control animals. WB:WBPerson557 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000407 obsolete ray loss true The process through which a dauer larva reverts to normal developmental programs is blocked. C_elegans_phenotype_ontology WBPhenotype:0000408 dauer recovery inhibited The process through which a dauer larva reverts to normal developmental programs is blocked. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in the form, structure or composition of any of its parts at different stages of the lifecycle, compared to control animals. Vab C_elegans_phenotype_ontology WBPhenotype:0000409 organism morphology variable Animals exhibit variations in the form, structure or composition of any of its parts at different stages of the lifecycle, compared to control animals. WB:WBPerson2021 WB:WBPerson557 Animals lack the stereotyped sequence of muscle contractions that result in defecation over a fixed time period compared to control. C_elegans_phenotype_ontology WBPhenotype:0000410 no defecation cycle Animals lack the stereotyped sequence of muscle contractions that result in defecation over a fixed time period compared to control. WB:WBPerson2021 WB:WBPerson557 Animals die as rigid, rod-like larva. In C. elegans this defect is often caused by the misspecification of the excretory duct cell. Lvl C_elegans_phenotype_ontology Let WBPhenotype:0000411 rod like larval lethal Animals die as rigid, rod-like larva. In C. elegans this defect is often caused by the misspecification of the excretory duct cell. WB:WBPaper00001366 WB:WBPaper00002764 WB:WBPerson2021 Failure to execute the characteristic response to 1-octanol as defined by control animals. In C.elegans 1-octanol is typically a repellant. C_elegans_phenotype_ontology WBPhenotype:0000412 octanol chemotaxis defective Failure to execute the characteristic response to 1-octanol as defined by control animals. In C.elegans 1-octanol is typically a repellant. WB:WBPaper00002314 Pharyngeal muscle is immobilized resulting in lack of pumping or lack of response to external stimulation. C_elegans_phenotype_ontology WBPhenotype:0000413 pharyngeal muscle paralyzed Pharyngeal muscle is immobilized resulting in lack of pumping or lack of response to external stimulation. WB:WBPerson557 WB:cab The cell takes on a different identity from which it was initially committed. C_elegans_phenotype_ontology WBPhenotype:0000414 cell fate transformation The cell takes on a different identity from which it was initially committed. GO:0045165 WB:WBPaper00002924 WB:WBPerson712 Animals exhibit variations in the cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents, compared to control. necrotic cell death abnormal C_elegans_phenotype_ontology WBPhenotype:0000415 necrotic cell death variant Animals exhibit variations in the cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents, compared to control. GO:0070265 WB:WBPerson712 Variations in the generation of the nutrient protein produced by intestinal cells and secreted by them into the pseudocoelom, from which it can be shared with other tissues in the body compared to control (Wormatlas). yolk synthesis abnormal C_elegans_phenotype_ontology vitellogenin synthesis abnormal WBPhenotype:0000416 yolk synthesis variant Variations in the generation of the nutrient protein produced by intestinal cells and secreted by them into the pseudocoelom, from which it can be shared with other tissues in the body compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 The process of physical partitioning and separation of a cell into daughter cells is abolished. C_elegans_phenotype_ontology WBPhenotype:0000417 cell division failure The process of physical partitioning and separation of a cell into daughter cells is abolished. WB:WBPerson2021 WB:WBPerson557 The physical partitioning and separation of an intestinal cell into daughter cells is abolished. C_elegans_phenotype_ontology WBPhenotype:0000418 intestinal cell division failure The physical partitioning and separation of an intestinal cell into daughter cells is abolished. WB:WBPerson2021 WB:WBPerson557 Animals die at the L3 stage of the life cycle. Let Lvl C_elegans_phenotype_ontology WBPhenotype:0000419 L3 lethal Animals die at the L3 stage of the life cycle. WB:WBPerson2021 Animals respond to levamisole at a lower concentration or a shorter exposure compared to control animals. Levamisole is a cholinergic agonist. C_elegans_phenotype_ontology tetramisole hypersensitive WBPhenotype:0000420 levamisole hypersensitive Animals respond to levamisole at a lower concentration or a shorter exposure compared to control animals. Levamisole is a cholinergic agonist. WB:WBPerson557 Animals fail to respond to the concentration of levamisole that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans resistance to levamisole is often assayed via body contraction response, ventral tail curling response etc. Lev R C_elegans_phenotype_ontology tetramisole resistant WBPhenotype:0000421 levamisole resistant Animals fail to respond to the concentration of levamisole that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans resistance to levamisole is often assayed via body contraction response, ventral tail curling response etc. WB:WBPaper00000484 WB:WBPerson2021 Animals exhibit spasmodic muscle twitching superimposed on normal sinusoidal motion. C_elegans_phenotype_ontology WBPhenotype:0000422 twitcher Animals exhibit spasmodic muscle twitching superimposed on normal sinusoidal motion. WB:WBPaper00000484 Any variation in the contractions of the muscles in the most anterior body region of the animal compared to control. head muscle contraction abnormal C_elegans_phenotype_ontology WBPhenotype:0000423 head muscle contraction variant Any variation in the contractions of the muscles in the most anterior body region of the animal compared to control. WB:WBPerson557 Any variation in the characteristic expression of a gene product, as detected by antibody staining, compared to control animals. antibody staining abnormal C_elegans_phenotype_ontology WBPhenotype:0000424 antibody staining variant Any variation in the characteristic expression of a gene product, as detected by antibody staining, compared to control animals. WB:WBPerson2021 WB:WBPerson557 Any variation that results in a decrease in the characteristic expression of a gene product, as detected by antibody staining, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000425 antibody staining reduced Any variation that results in a decrease in the characteristic expression of a gene product, as detected by antibody staining, compared to control animals. WB:WBPerson2021 WB:WBPerson557 Any variation that results in an increase in the characteristic expression of a gene product, as detected by antibody staining, compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000426 antibody staining increased Any variation that results in an increase in the characteristic expression of a gene product, as detected by antibody staining, compared to control animals. WB:WBPerson2021 WB:WBPerson557 Animals lack the rigid external coating which is secreted by the hypodermis, seam and some interfacial epithelial cells (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000427 no cuticle Animals lack the rigid external coating which is secreted by the hypodermis, seam and some interfacial epithelial cells (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Adult animals lack the rigid external coating which is secreted by the hypodermis, seam and some interfacial epithelial cells (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000428 no adult cuticle Adult animals lack the rigid external coating which is secreted by the hypodermis, seam and some interfacial epithelial cells (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of the specialized structures of the animal which allow the successful transfer of sperm from one organism to another, compared to control. copulatory structure development abnormal C_elegans_phenotype_ontology WBPhenotype:0000429 copulatory structure development variant Any variation in the progression of the specialized structures of the animal which allow the successful transfer of sperm from one organism to another, compared to control. WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of the specialized structures of the male tail which allow the animal to sense the presence of the hermaphrodite, search her body for the vulval opening, grasp onto the vulva, and to transfer sperm over time from its formation to its mature structure compared to control (Wormatlas). male copulatory structure development abnormal C_elegans_phenotype_ontology WBPhenotype:0000430 male copulatory structure development variant Any variation in the progression of the specialized structures of the male tail which allow the animal to sense the presence of the hermaphrodite, search her body for the vulval opening, grasp onto the vulva, and to transfer sperm over time from its formation to its mature structure compared to control (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of the specialized structures of a hermaphrodite which allow the successful transfer of sperm from a male, compared to control. hermaphrodite copulatory structure development abnormal C_elegans_phenotype_ontology WBPhenotype:0000431 hermaphrodite copulatory structure development variant Any variation in the progression of the specialized structures of a hermaphrodite which allow the successful transfer of sperm from a male, compared to control. WB:WBPerson2021 WB:WBPerson557 Animals lack the specialized structures of the male tail which allow the animal to sense the presence of the hermaphrodite, search her body for the vulval opening, grasp onto the vulva, and to transfer sperm (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000432 male copulatory structure absent Animals lack the specialized structures of the male tail which allow the animal to sense the presence of the hermaphrodite, search her body for the vulval opening, grasp onto the vulva, and to transfer sperm (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Variations in the processes involving the production of new DNA strands compared to control. DNA synthesis abnormal C_elegans_phenotype_ontology WBPhenotype:0000433 DNA synthesis variant Variations in the processes involving the production of new DNA strands compared to control. GO:0006260 WB:WBPerson2021 The developmental process by which a progressive change in the state of some part of an organism specifically contributing to its ability to form offspring is impaired. C_elegans_phenotype_ontology WBPhenotype:0000434 sexual maturation defective The developmental process by which a progressive change in the state of some part of an organism specifically contributing to its ability to form offspring is impaired. GO:0003006 WB:WBPerson2021 WB:WBPerson557 OBSOLETE. Any change in the subcellular localization of a protein. C_elegans_phenotype_ontology WBPhenotype:0000435 obsolete protein localization abnormal true Any variation in the placement of a protein within in a cell or cellular compartment compared to control. WBPhenotype:0000435 protein localization abnormal protein subcellular localization abnormal C_elegans_phenotype_ontology WBPhenotype:0000436 protein subcellular localization variant Any variation in the placement of a protein within in a cell or cellular compartment compared to control. WB:WBPerson557 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000437 obsolete heterochronic defect true Variations that result in the deceleration of the rate, frequency or extent of the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition, compared to control. C_elegans_phenotype_ontology WBPhenotype:0000438 retarded heterochronic variations Variations that result in the deceleration of the rate, frequency or extent of the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition, compared to control. GO:0040034 WB:WBPerson2021 WB:WBPerson557 Variations that result in the acceleration of the rate, frequency or extent of the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition, compared to control. C_elegans_phenotype_ontology WBPhenotype:0000439 precocious heterochronic variations Variations that result in the acceleration of the rate, frequency or extent of the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition, compared to control. GO:0040034 WB:WBPerson2021 WB:WBPerson557 The structure made by the processes of the excretory canal cell is increased in size compared to control. In C. elegans this is an H-shaped structure which extends almost the full length of the body on both sides of the animal, generally in contact with the lateral hypodermis and the pseudocoelom (Wormatlas). C_elegans_phenotype_ontology long excretory canals WBPhenotype:0000440 excretory canals long The structure made by the processes of the excretory canal cell is increased in size compared to control. In C. elegans this is an H-shaped structure which extends almost the full length of the body on both sides of the animal, generally in contact with the lateral hypodermis and the pseudocoelom (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Tails change shape and undergo retraction thereby forming a 'peloderan' or 'rounded' adult tail. C_elegans_phenotype_ontology WBPhenotype:0000441 tail rounded Tails change shape and undergo retraction thereby forming a 'peloderan' or 'rounded' adult tail. WB:WBPerson2021 WB:WBPerson557 The developmental progression of a larva over time, from its formation to its mature structure is delayed compared to control. The larva is the early, immature form of an animal between hatching and adulthood. C_elegans_phenotype_ontology WBPhenotype:0000442 larval development retarded The developmental progression of a larva over time, from its formation to its mature structure is delayed compared to control. The larva is the early, immature form of an animal between hatching and adulthood. WB:WBPerson2021 WB:WBPerson557 Any variation in the appearance of the elongated sclerotized structures covered by a hardened layer of cuticle in the male tail (which are actively everted during copulation to fasten the male copulatory fan to the vulva) compared to control. spicule morphology abnormal C_elegans_phenotype_ontology WBPhenotype:0000443 spicule morphology variant Any variation in the appearance of the elongated sclerotized structures covered by a hardened layer of cuticle in the male tail (which are actively everted during copulation to fasten the male copulatory fan to the vulva) compared to control. WB:WBPerson2021 WB:WBPerson557 The length of the adult male tail, including the lateral fan and rays, is extended compared to control. C_elegans_phenotype_ontology WBPhenotype:0000444 bursa elongated The length of the adult male tail, including the lateral fan and rays, is extended compared to control. WB:WBPerson2021 WB:WBPerson557 Males generate yolk, the nutrient protein, normally produced and secreted by hermaphrodite or female intestinal cells. C_elegans_phenotype_ontology vitellogenin synthesis in males WBPhenotype:0000445 yolk synthesis in males Males generate yolk, the nutrient protein, normally produced and secreted by hermaphrodite or female intestinal cells. WB:WBPerson2021 WB:WBPerson557 Animals execute extra larval molts compared to control. C_elegans_phenotype_ontology WBPhenotype:0000446 supernumerary molt Animals execute extra larval molts compared to control. WB:WBPerson2021 WB:WBPerson557 Variations in the progression of an animal over time from the end of larval stage to a mature adult compared to control animals. adult development abnormal C_elegans_phenotype_ontology WBPhenotype:0000447 adult development variant Variations in the progression of an animal over time from the end of larval stage to a mature adult compared to control animals. WB:WBPerson2021 WB:WBPerson557 Any variation in the progression of the formation of the rigid external coating (which is secreted by the hypodermis, seam and some interfacial epithelial cells) over time in adults compared to control animals (Wormatlas). adult cuticle development abnormal C_elegans_phenotype_ontology WBPhenotype:0000448 adult cuticle development variant Any variation in the progression of the formation of the rigid external coating (which is secreted by the hypodermis, seam and some interfacial epithelial cells) over time in adults compared to control animals (Wormatlas). WB:WBPerson2021 WB:WBPerson557 A duplication of the developmental program that forms the adult-type rigid external coating which is secreted by the hypodermis, seam and some interfacial epithelial cells. C_elegans_phenotype_ontology WBPhenotype:0000449 second adult cuticle A duplication of the developmental program that forms the adult-type rigid external coating which is secreted by the hypodermis, seam and some interfacial epithelial cells. WB:WBPaper00001439 OBSOLETE. C_elegans_phenotype_ontology WBPhenotype:0000450 obsolete swollen male tail true Any irregular swelling in discrete regions of the head. C_elegans_phenotype_ontology WBPhenotype:0000451 head protrusion Any irregular swelling in discrete regions of the head. WB:WBPerson2021 WB:WBPerson557 Any irregular swelling in discrete regions of the tail, usually caused by a local defect in the normal smooth tapering of the hypodermis and/or cuticle (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000452 tail protrusions Any irregular swelling in discrete regions of the tail, usually caused by a local defect in the normal smooth tapering of the hypodermis and/or cuticle (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Any irregular swelling in discrete regions of the body region between the head and the tail. C_elegans_phenotype_ontology WBPhenotype:0000453 body protrusions Any irregular swelling in discrete regions of the body region between the head and the tail. WB:WBPerson2021 WB:WBPerson557 The anterior end (which typically includes the anterior sensilla, pharynx and all muscles that are innervated by the nerve ring)of the body appears distorted, usually due to uncharacteristic winding. C_elegans_phenotype_ontology WBPhenotype:0000454 head twisted The anterior end (which typically includes the anterior sensilla, pharynx and all muscles that are innervated by the nerve ring)of the body appears distorted, usually due to uncharacteristic winding. WB:WBPerson2021 WB:WBPerson557 Animals exhibit abrupt transitions while traveling from one location to another. C_elegans_phenotype_ontology WBPhenotype:0000455 jerky movement Animals exhibit abrupt transitions while traveling from one location to another. WB:WBPerson2021 WB:WBPerson557 Variations in characteristic response with respect to perception or transmission of a touch stimulus compared to responses in control animals. C_elegans_phenotype_ontology touch insensitive WBPhenotype:0000456 touch resistant Variations in characteristic response with respect to perception or transmission of a touch stimulus compared to responses in control animals. WB:WBPerson557 Animals show enhanced suceptibility to deprivation of nourishment, compared to control. C_elegans_phenotype_ontology WBPhenotype:0000457 organism starvation hypersensitive Animals show enhanced suceptibility to deprivation of nourishment, compared to control. WB:WBPerson2021 Animals show enhanced tolerance to deprivation of nourishment, compared to control. C_elegans_phenotype_ontology WBPhenotype:0000458 starvation resistant Animals show enhanced tolerance to deprivation of nourishment, compared to control. WB:WBPerson2021 Animals exhibit variations in their response to any chemical substance that is used for killing pests, compared to that observed in control animals. pesticide response abnormal C_elegans_phenotype_ontology WBPhenotype:0000459 pesticide response variant Animals exhibit variations in their response to any chemical substance that is used for killing pests, compared to that observed in control animals. WB:WBPerson557 Animals exhibit variations in their response to paraquat compared to that observed in control animals. paraquat response abnormal C_elegans_phenotype_ontology methyl viologen response abnormal WBPhenotype:0000460 paraquat response variant Animals exhibit variations in their response to paraquat compared to that observed in control animals. WB:WBPerson557 Animals fail to respond to the concentration of paraquat that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000461 paraquat resistant Animals fail to respond to the concentration of paraquat that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 Animals respond to paraquat at a lower concentration or a shorter exposure compared to control animals. reactive oxygen species hypersensitive C_elegans_phenotype_ontology WBPhenotype:0000462 paraquat hypersensitive Animals respond to paraquat at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 reactive oxygen species hypersensitive WB:WBPaper00031296 Animals exhibit variations in processes that are responsible for chemical changes compared to control animals. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. metabolic pathway abnormal C_elegans_phenotype_ontology WBPhenotype:0000463 metabolic pathway variant Animals exhibit variations in processes that are responsible for chemical changes compared to control animals. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. GO:0008152 WB:WBPerson712 Animals exhibit variations in their response to oxygen compared to that observed in control animals. oxygen response abnormal C_elegans_phenotype_ontology WBPhenotype:0000464 oxygen response variant Animals exhibit variations in their response to oxygen compared to that observed in control animals. WB:WBPerson557 Animals fail to respond to the high concentrations of oxygen that elicit a response in control animals. C_elegans_phenotype_ontology WBPhenotype:0000465 high oxygen resistant Animals fail to respond to the high concentrations of oxygen that elicit a response in control animals. WB:WBPerson2021 Animals respond to hyperoxic (high oxygen tension) conditions after a shorter exposure time compared to control. C_elegans_phenotype_ontology WBPhenotype:0000466 high oxygen hypersensitive Animals respond to hyperoxic (high oxygen tension) conditions after a shorter exposure time compared to control. GO:0055093 WB:WBPerson2021 Animals exhibit an increase in the intensity of fluorescence signals in intestinal cells with advancing age, compared to control. C_elegans_phenotype_ontology WBPhenotype:0000467 age associated fluorescence increased Animals exhibit an increase in the intensity of fluorescence signals in intestinal cells with advancing age, compared to control. WB:WBPaper00033040 WB:WBPerson2021 Animals exhibit a decrease in the intensity of fluorescence signals in intestinal cells with advancing age, compared to control. C_elegans_phenotype_ontology WBPhenotype:0000468 age associated fluorescence reduced Animals exhibit a decrease in the intensity of fluorescence signals in intestinal cells with advancing age, compared to control. WB:WBPerson2021 The daughters of the Q neuroblasts exhibit variation in their characteristic movements compared to control animals. Q neuroblast lineage migration abnormal C_elegans_phenotype_ontology WBPhenotype:0000469 Q neuroblast lineage migration variant The daughters of the Q neuroblasts exhibit variation in their characteristic movements compared to control animals. WB:WBPaper00001954 WB:WBPaper00031356 WB:WBPerson712 Any variation in the normal anterior movement of the HSN motor neurons from their birthplace in the tail to positions near the middle of the embryo compared to control animals. HSN migration abnormal C_elegans_phenotype_ontology WBPhenotype:0000470 HSN migration variant Any variation in the normal anterior movement of the HSN motor neurons from their birthplace in the tail to positions near the middle of the embryo compared to control animals. WB:WBPaper00001836 WB:WBPerson2021 Any variation in the normal posterior movement of the ALM mechanosensory neurons from their birthplace (anterior to the V1 hypodermal cell) to positions in between the V2 and V3 cells in the embryo compared to control animals. ALM migration abnormal C_elegans_phenotype_ontology WBPhenotype:0000471 ALM migration variant Any variation in the normal posterior movement of the ALM mechanosensory neurons from their birthplace (anterior to the V1 hypodermal cell) to positions in between the V2 and V3 cells in the embryo compared to control animals. WB:WBPaper00001304 WB:WBPaper00003058 WB:WBPerson2021 Animals lack the early blast cells that give rise to the gut tissue (Wormatlas). gutless C_elegans_phenotype_ontology WBPhenotype:0000472 endoderm absent Animals lack the early blast cells that give rise to the gut tissue (Wormatlas). WB:WBPerson2021 WB:WBPerson557 Animals become increasingly sluggish/immobilized as they age. C_elegans_phenotype_ontology WBPhenotype:0000473 progressive paralysis Animals become increasingly sluggish/immobilized as they age. WB:WBPaper00001709 Any variation in the connection of the cell(s) whose principal function is to provide contractile forces with its neighboring cells or tissues compared to control. Mua muscle attachment abnormal C_elegans_phenotype_ontology WBPhenotype:0000474 muscle attachment variant Any variation in the connection of the cell(s) whose principal function is to provide contractile forces with its neighboring cells or tissues compared to control. WB:WBPerson2021 WB:WBPerson557 Animals fail to establish or maintain the connection between cell(s) whose principal function is to provide contractile forces and its neighboring cells or tissues. C_elegans_phenotype_ontology WBPhenotype:0000475 muscle detached Animals fail to establish or maintain the connection between cell(s) whose principal function is to provide contractile forces and its neighboring cells or tissues. WB:WBPerson2021 WB:WBPerson557 The connection between cell(s) whose principal function is to provide contractile forces and its neighboring cells or tissues diminishes over time. C_elegans_phenotype_ontology WBPhenotype:0000476 progressive muscle detachment The connection between cell(s) whose principal function is to provide contractile forces and its neighboring cells or tissues diminishes over time. WB:WBPerson2021 WB:WBPerson557 Any variation in the change in direction of a wave of light after passage through the nucleolus compared to control. The nucleolus is a small dense body in the nucleus. nucleolus refraction abnormal C_elegans_phenotype_ontology WBPhenotype:0000477 nucleolus refraction variant Any variation in the change in direction of a wave of light after passage through the nucleolus compared to control. The nucleolus is a small dense body in the nucleus. WB:WBPerson2021 WB:WBPerson557 Variations in the ability of an animal to remain within a defined temperature. In C. elegans, animals tend to track and stay within a temperature that is most closely related to their cultivation temperature. isothermal tracking behavior abnormal C_elegans_phenotype_ontology thermotaxis abnormal WBPhenotype:0000478 isothermal tracking behavior variant Variations in the ability of an animal to remain within a defined temperature. In C. elegans, animals tend to track and stay within a temperature that is most closely related to their cultivation temperature. WB:WBPaper00002214 Eggs show deficiencies in chroma resulting in increased translucency. C_elegans_phenotype_ontology WBPhenotype:0000479 egg pale Eggs show deficiencies in chroma resulting in increased translucency. WB:WBPerson2021 WB:WBPerson557 Failure to execute the characteristic response to pyrazine as defined by control animals. In C. elegans pyrazine is typically an attractant. C_elegans_phenotype_ontology WBPhenotype:0000480 pyrazine chemotaxis defective Failure to execute the characteristic response to pyrazine as defined by control animals. In C. elegans pyrazine is typically an attractant. WB:WBPaper00001786 Any variation in the directed movement of an animal in response to chemical repellants as defined by control animals. negative chemotaxis abnormal C_elegans_phenotype_ontology chemical avoidance abnormal chemoaversion abnormal WBPhenotype:0000481 negative chemotaxis variant Any variation in the directed movement of an animal in response to chemical repellants as defined by control animals. GO:0050919 WB:cab Failure to execute the characteristic response to garlic as defined by control animals. In C. elegans, garlic is typically a repellent. C_elegans_phenotype_ontology WBPhenotype:0000482 garlic chemotaxis defective Failure to execute the characteristic response to garlic as defined by control animals. In C. elegans, garlic is typically a repellent. WB:WBPaper00001374 Animals lack the different inclusions within the intestinal cytoplasm, including birefringent crystalline objects and other dark-staining endosomes. In C. elegans these contents typically include glycogen granules (polysaccharide storage), rhabditin (carbohydrate storage), yolk granules (lipid and protein), and concentrated waste products (Wormatlas). C_elegans_phenotype_ontology WBPhenotype:0000483 no gut granules Animals lack the different inclusions within the intestinal cytoplasm, including birefringent crystalline objects and other dark-staining endosomes. In C. elegans these contents typically include glycogen granules (polysaccharide storage), rhabditin (carbohydrate storage), yolk granules (lipid and protein), and concentrated waste products (Wormatlas). WB:WBPerson2021 WB:WBPerson557 The organism's size during the embryonic developmental stage is decreased compared to that observed in control. C_elegans_phenotype_ontology WBPhenotype:0000484 embryo small The organism's size during the embryonic developmental stage is decreased compared to that observed in control. WB:WBPerson2021 WB:WBPerson557 The survival of animals in the alternative larval stage which they enter when placed under conditions of environmental stress is reduced. C_elegans_phenotype_ontology reduced dauer survival WBPhenotype:0000485 dauer death increased The survival of animals in the alternative larval stage which they enter when placed under conditions of environmental stress is reduced. WB:WBPerson2021 WB:WBPerson557 Animals respond to colchicine at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000486 colchicine hypersensitive Animals respond to colchicine at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 Animals fail to respond to the concentration of colchicine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000487 colchicine resistant Animals fail to respond to the concentration of colchicine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 Animals respond to chloroquine at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000488 chloroquine hypersensitive Animals respond to chloroquine at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 Animals fail to respond to the concentration of chloroquine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000489 chloroquine resistant Animals fail to respond to the concentration of chloroquine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. WB:WBPerson557 The components of the feeding organ fail to be arranged in the same manner as control animals. C_elegans_phenotype_ontology WBPhenotype:0000490 pharynx disorganized The components of the feeding organ fail to be arranged in the same manner as control animals. WB:WBPerson2021 WB:WBPerson557 Any observed morphological defects of the isthmus. isthmus morphology abnormal C_elegans_phenotype_ontology isthmus malformed WBPhenotype:0000491 isthmus morphology defective Any observed morphological defects of the isthmus. WB:WBPerson2021 Any variation in the form, structure or composition of the extended anterior region of the pharynx lying just anterior to the isthmus and terminal bulb compared to control (Wormatlas). corpus morphology abnormal C_elegans_phenotype_ontology corpus malformed WBPhenotype:0000492 corpus morphology defective Any variation in the form, structure or composition of the extended anterior region of the pharynx lying just anterior to the isthmus and terminal bulb compared to control (Wormatlas). WB:WBPerson2021 Any variation in the form, structure or composition of the first pharyngeal bulb compared to control. metacorpus morphology abnormal C_elegans_phenotype_ontology metacarpas malformed WBPhenotype:0000493 metacorpus morphology defective Any variation in the form, structure or composition of the first pharyngeal bulb compared to control. WB:WBPerson2021 Cessation of development that normally occurs in C. elegans 460-520 min after the first cleavage at 20C, the stage between the 1.5-fold and 3-fold embryo. C_elegans_phenotype_ontology WBPhenotype:0000494 two fold arrest Cessation of development that normally occurs in C. elegans 460-520 min after the first cleavage at 20C, the stage between the 1.5-fold and 3-fold embryo. WB:WBPerson101 Animals have finger-like sensory sensilla (rays) that are present in places they are normally not found, when compared to the location in control animals. C_elegans_phenotype_ontology WBPhenotype:0000495 ray ectopic Animals have finger-like sensory sensilla (rays) that are present in places they are normally not found, when compared to the location in control animals. WB:WBPerson2021 WB:WBPerson557 Males lack the specialized sensory papillae that lie along the posterior half of the body. C_elegans_phenotype_ontology WBPhenotype:0000496 male postdeirid sensilla absent Males lack the specialized sensory papillae that lie along the posterior half of the body. WB:WBPerson2021 WB:WBPerson557 Animals exhibit variations in their response to gamma ray radiation compared to that observed in control animals. organism gamma ray response abnormal C_elegans_phenotype_ontology WBPhenotype:0000497 organism gamma ray response variant Animals exhibit variations in their response to gamma ray radiation compared to that observed in control animals. WB:WBPerson557 Animals exhibit variations in their response to methyl methanesulfonate compared to that observed in control animals. methyl methanesulfonate response abnormal C_elegans_phenotype_ontology MMS response abnormal WBPhenotype:0000498 methyl methanesulfonate response variant Animals exhibit variations in their response to methyl methanesulfonate compared to that observed in control animals. WB:WBPerson557 Animals exhibit variations in their response to ethyl methanesulfonate (EMS) compared to that observed in control animals. ethyl methanesulfonate response abnormal C_elegans_phenotype_ontology EMS response abnormal WBPhenotype:0000499 ethyl methanesulfonate response variant Animals exhibit variations in their response to ethyl methanesulfonate (EMS) compared to that observed in control animals. WB:WBPerson557 Animals respond to an acetylcholinesterase inhibitor at a lower concentration or a shorter exposure compared to control animals. C_elegans_phenotype_ontology WBPhenotype:0000500 acetylcholinesterase inhibitor hypersensitive Animals respond to an acetylcholinesterase inhibitor at a lower concentration or a shorter exposure compared to control animals. WB:WBPerson557 The body of the animal rotates around its long axis as the animal moves, causing the animal to move in a circular pattern in the left-handed direction. In liquid media, wave propogation is helical rather than planar. C_elegans_phenotype_ontology Rol WBPhenotype:0000501 left handed roller The body of the animal rotates around its long axis as the animal moves, causing the animal to move in a circular pattern in the left-handed direction. In liquid media, wave propogation is helical rather than planar. WB:WBPerson2021 WB:WBPerson557