format-version: 1.2
data-version: releases/2022-09-13
date: 04:07:2013 20:24
saved-by: jonathanbard
auto-generated-by: OBO-Edit 2.1.1-beta7
default-namespace: anatomical_entity_ontology
remark: this version corrects the namespace and includes some flybase alt_IDs
ontology: aeo
property_value: typeref "anatomical_entity_ontology" xsd:string

[Term]
id: AEO:0000013
name: single-cell tissue
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003013
def: "Anatomical structure composed of a single cell." [CARO:MAH]
is_a: CARO:0000043 ! simple tissue

[Term]
id: AEO:0000078
name: lumen of tube
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003078
alt_id: UBERON:0005082
def: "The inner space within a tube." [AEO:JB]
synonym: "tube lumen" RELATED []
is_a: AEO:0000221 ! open anatomical space

[Term]
id: AEO:0000079
name: lumen of epithelial sac
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003079
def: "A small cavity bounded by an epithelium." [AEO:JB]
synonym: "cavity of vesicle" RELATED []
is_a: AEO:0000222 ! enclosed anatomical space

[Term]
id: AEO:0000080
name: foramen
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003080
def: "A hole in a tissue." [AEO:JB]
is_a: CARO:0000010 ! anatomical surface

[Term]
id: AEO:0000081
name: matrix-based tissue
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003081
def: "A tissue whose predominant feature is extracellular matrix which may or may not be highly hydrated or calcified." [AEO:JB]
is_a: CARO:0000043 ! simple tissue

[Term]
id: AEO:0000082
name: bone
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003082
def: "Ossified structure that is predominantly extracellular matrix and forms part of the support system of the body." [AEO:JB]
is_a: CARO:0000055 ! multi-tissue structure

[Term]
id: AEO:0000083
name: endochondral bone
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003083
def: "Bone that is preformed in cartilage." [AEO:JB, VAO:0000145]
is_a: AEO:0000082 ! bone
relationship: has_part CL:0000058 ! chondroblast
relationship: has_part CL:0000062 ! osteoblast
relationship: has_part CL:0000138 ! chondrocyte
relationship: part_of AEO:0000168 ! skeletal system

[Term]
id: AEO:0000085
name: membrane bone
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003085
def: "Bone that forms directly from mesenchyme." [AEO:JB, VAO:0000023]
is_a: AEO:0000082 ! bone
relationship: has_part CL:0000062 ! osteoblast
relationship: part_of AEO:0000168 ! skeletal system

[Term]
id: AEO:0000086
name: sesamoid bone
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003086
def: "An endochondral bone that forms within tendenous or ligamentous matrix." [AEO:JB, VAO:0000137]
is_a: AEO:0000083 ! endochondral bone
relationship: has_part CL:0000058 ! chondroblast
relationship: has_part CL:0000138 ! chondrocyte
relationship: part_of AEO:0000168 ! skeletal system

[Term]
id: AEO:0000087
name: cartilage
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003087
def: "Dense connective tissue made primarily of type II collagen." [AEO:JB, VAO:0000040]
is_a: AEO:0000081 ! matrix-based tissue
relationship: part_of AEO:0000168 ! skeletal system

[Term]
id: AEO:0000090
name: ligament
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003090
def: "A strap of predominantly extracellular matrix connecting two bones." [AEO:JB]
is_a: AEO:0000081 ! matrix-based tissue
relationship: has_part CL:0000057 ! fibroblast
relationship: has_part CL:0000327 ! extracellular matrix secreting cell
relationship: part_of AEO:0000168 ! skeletal system

[Term]
id: AEO:0000091
name: tendon
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003091
def: "A strap of predominantly extracellular matrix connecting a muscle to a bone." [AEO:JB]
is_a: AEO:0000081 ! matrix-based tissue
relationship: has_part CL:0000057 ! fibroblast
relationship: has_part CL:0000327 ! extracellular matrix secreting cell
relationship: part_of AEO:0000168 ! skeletal system

[Term]
id: AEO:0000092
name: aponeurosis
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003092
def: "A sheet of extracellular matrix." [AEO:JB]
is_a: AEO:0000081 ! matrix-based tissue
relationship: has_part CL:0000327 ! extracellular matrix secreting cell
relationship: has_part CL:0002320 ! connective tissue cell

[Term]
id: AEO:0000093
name: non-connected functional system
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003093
alt_id: FBbt:00007278
def: "An anatomical group whose component structures share a common function." [AEO:JB]
is_a: CARO:0000041 ! anatomical cluster

[Term]
id: AEO:0000094
name: sense organ
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003094f
alt_id: FBbt:00005155
def: "Multicellular anatomical structure with largely bona fide boundary that transduces some sensory stimulus to the nervous system." [AEO:JB]
is_a: CARO:0000024 ! compound organ

[Term]
id: AEO:0000095
name: fluid-based anatomical entity
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003095
def: "Fluid anatomical entity containing cells." [AEO:JB]
is_a: CARO:0000055 ! multi-tissue structure

[Term]
id: AEO:0000096
name: gland
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003096
def: "A multi-tissue structure that produces a secretion for use elsewhere in the body." [AEO:JB]
is_a: CARO:0000055 ! multi-tissue structure

[Term]
id: AEO:0000097
name: ducted gland
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003097
def: "A gland that releases its secretion through a duct." [AEO:JB]
synonym: "exocrine gland." RELATED []
is_a: AEO:0000096 ! gland

[Term]
id: AEO:0000098
name: ductless gland
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003098
def: "A gland that releases its secretion directly into the bloodstream, or equivalent for an invertebrate." [AEO:JB]
synonym: "endocrine gland." RELATED [AEO:JB]
is_a: AEO:0000096 ! gland

[Term]
id: AEO:0000099
name: keratin-based structure
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003099
def: "Acellular anatomical structure whose predominant constituent is keratin." [AEO:JB]
is_a: CARO:0000040 ! acellular anatomical structure

[Term]
id: AEO:0000100
name: chitin-based structure
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003100
def: "Acellular anatomical structure whose predominant constituent is chitin." [AEO:JB]
is_a: CARO:0000040 ! acellular anatomical structure

[Term]
id: AEO:0000103
name: body
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003103
def: "The region of the organism associated with the visceral organs." [AEO:JB]
is_a: CARO:0000032 ! organism subdivision

[Term]
id: AEO:0000106
name: head
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003106
def: "The region of the body containing the brain and mouth." [AEO:JB]
is_a: CARO:0000032 ! organism subdivision

[Term]
id: AEO:0000108
name: neck
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003108
def: "The region of the body connecting the head and the body." [AEO:JB]
is_a: CARO:0000032 ! organism subdivision

[Term]
id: AEO:0000109
name: tail
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003109
def: "An external caudal extension of the body." [AEO:JB]
is_a: AEO:0000193 ! appendage

[Term]
id: AEO:0000111
name: mesothelium
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003111
def: "Epithelium derived from mesenchyme." [AEO:JB]
is_a: CARO:0000070 ! simple squamous epithelium

[Term]
id: AEO:0000114
name: epithelial tube
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003114
def: "An epithelial structure capable of allowing fluid flow." [AEO:JB]
is_a: CARO:0000066 ! epithelium
relationship: has_part CL:0000068 ! duct epithelial cell

[Term]
id: AEO:0000115
name: epithelial sac
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003115
def: "An epithelial pouch with a single opening." [AEO:JB]
is_a: CARO:0000066 ! epithelium
relationship: has_part CL:0000075 ! columnar/cuboidal epithelial cell

[Term]
id: AEO:0000117
name: arborising epithelial duct system
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003117
def: "A group of connected epithelial tubes with a single portal." [AEO:JB]
is_a: AEO:0000115 ! epithelial sac
relationship: has_part CL:0000068 ! duct epithelial cell

[Term]
id: AEO:0000118
name: epithelial plexus
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003118
def: "A network of interlinking epithelial tubes." [AEO:JB]
is_a: AEO:0000114 ! epithelial tube
relationship: has_part CL:0000068 ! duct epithelial cell

[Term]
id: AEO:0000119
name: epithelial vesicle
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003119
def: "A closed epithelium with a lumen." [AEO:JB]
is_a: CARO:0000066 ! epithelium
relationship: has_part CL:0000075 ! columnar/cuboidal epithelial cell

[Term]
id: AEO:0000122
name: muscle tissue
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003122
def: "A tissue composed of myoblasts or muscle cells." [AEO:JB]
is_a: CARO:0000043 ! simple tissue

[Term]
id: AEO:0000123
name: neural tissue
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003123
def: "Tissue composed predominantly of neurons." [AEO:JB]
is_a: CARO:0000043 ! simple tissue

[Term]
id: AEO:0000125
name: developing anatomical structure
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003125
alt_id: UBERON:0005423
def: "A structure whose morphology or state of differentiation will change during normal development." [AEO:JB]
is_a: CARO:0000003 ! anatomical structure

[Term]
id: AEO:0000126
name: larva
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003126
def: "A post-embryonic juvenile form which will undergo metamorphosis to become the adult." [AEO:JB]
is_a: CARO:0000012 ! multi-cellular organism

[Term]
id: AEO:0000127
name: apoptosing developing anatomical entity
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003127
def: "An embryonic anatomical structure undergoing apoptosis." [AEO:JB]
is_a: AEO:0000125 ! developing anatomical structure
relationship: has_part CL:0000445 ! apoptosis fated cell

[Term]
id: AEO:0000129
name: functioning and developing structure
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003129
def: "An embryonic entity that displays a physiological function but whose strucuture is not yet fully formed." [AEO:JB]
is_a: AEO:0000125 ! developing anatomical structure

[Term]
id: AEO:0000131
name: developing structure with stem cells
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003131
def: "Embronic structure that contains stem cellsr that may contribute to its future development or maintenance or to its future development or maintenance of another tissue." [AEO:JB]
is_a: AEO:0000125 ! developing anatomical structure
relationship: has_part CL:0000034 ! stem cell

[Term]
id: AEO:0000132
name: transitional anatomical structure
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003132
def: "An embryonic anatomical entity that will turn into one or more other anatomical entities, perhaps with other anatomical entities, later in development." [AEO:JB]
is_a: AEO:0000125 ! developing anatomical structure

[Term]
id: AEO:0000135
name: ganglion
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003135
def: "A group of neurons, usually outside the CNS, which relay neuronal signals." [AEO:JB]
is_a: AEO:0000123 ! neural tissue

[Term]
id: AEO:0000136
name: neuronal nucleus
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003136
def: "A localised domain of predominantly neuronal tissue in the central nervous system." [AEO:JB]
is_a: AEO:0001012 ! neuronal grey matter
relationship: has_part CL:0000127 ! astrocyte
relationship: has_part CL:0000128 ! oligodendrocyte
relationship: has_part CL:0000129 ! microglial cell

[Term]
id: AEO:0000137
name: nerve
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003137
def: "A group of neurons that provides a nervous supply." [AEO:JB]
is_a: AEO:0000123 ! neural tissue

[Term]
id: AEO:0000138
name: nerve plexus
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003138
def: "A complex of interconnecting nerves." [AEO:JB]
is_a: AEO:0000123 ! neural tissue
relationship: has_part CL:0000526 ! afferent neuron
relationship: has_part CL:0000527 ! efferent neuron

[Term]
id: AEO:0000139
name: nerve fiber tract
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003139
def: "A fasciculated bundle of neuron projections, largely or completely lacking synapses." [CARO:0001001, GO:0043005]
synonym: "neuron projection bundle" RELATED [GO:0043005]
is_a: AEO:0001011 ! neuronal white matter

[Term]
id: AEO:0000140
name: striated muscle tissue
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003140
def: "A tissue composed of striated muscle cells." [AEO:JB]
is_a: AEO:0000122 ! muscle tissue
relationship: has_part CL:0000737 ! striated muscle cell

[Term]
id: AEO:0000141
name: smooth muscle tissue
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003141
def: "A tissue composed of smooth muscle cells." [AEO:JB]
is_a: AEO:0000122 ! muscle tissue
relationship: has_part CL:0000192 ! smooth muscle cell

[Term]
id: AEO:0000142
name: cardiac muscle tissue
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003142
def: "A tissue composed of cardiac muscle cells." [AEO:JB]
is_a: AEO:0000122 ! muscle tissue
relationship: has_part CL:0000746 ! cardiac muscle cell

[Term]
id: AEO:0000143
name: smooth muscle sphincter
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003143
def: "A ring of smooth muscle cells whose contraction closes the opening of the ring." [AEO:JB]
is_a: AEO:0000141 ! smooth muscle tissue
relationship: has_part CL:0000192 ! smooth muscle cell

[Term]
id: AEO:0000144
name: striated muscle sphincter
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003144
def: "A ring of striated muscle cells whose contraction closes the opening of the ring." [AEO:JB]
is_a: AEO:0000140 ! striated muscle tissue
relationship: has_part CL:0000737 ! striated muscle cell

[Term]
id: AEO:0000145
name: mesenchymal tissue
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003145
def: "A group of not-yet-terminally-differentiatied cells that can pack in three dimensions." [AEO:JB]
is_a: CARO:0000043 ! simple tissue

[Term]
id: AEO:0000146
name: dense mesenchyme tissue
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003146
def: "Mesenchyme with little extracellular matrix." [AEO:JB]
is_a: AEO:0000145 ! mesenchymal tissue
relationship: has_part CL:0000057 ! fibroblast

[Term]
id: AEO:0000147
name: cartilagenous condensation
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003147
def: "Cell condensation that is an aggregation of mesenchymal cells that are committed to differentiate into chondroblasts and chondrocytes." [AEO:JB, GO:curator, VAO:0000092]
is_a: AEO:0000148 ! developing mesenchymal condensation
relationship: has_part CL:0000058 ! chondroblast

[Term]
id: AEO:0000148
name: developing mesenchymal condensation
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003148
def: "A delimited region of dense mesenchyme within looser mesenchyme." [AEO:JB]
is_a: AEO:0000146 ! dense mesenchyme tissue
is_a: AEO:0001016 ! developing mesenchymal structure
relationship: has_part CL:0000335 ! mesenchyme condensation cell

[Term]
id: AEO:0000149
name: pre-muscle condensation
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003149
def: "A delimited region of dense mesenchyme within looser mesenchyme whose cells are committed to become myoblasts." [AEO:JB]
is_a: AEO:0000148 ! developing mesenchymal condensation
relationship: has_part CL:0000680 ! muscle precursor cell

[Term]
id: AEO:0000150
name: pre-cartilage condensation
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003150
def: "A delimited region of dense mesenchyme within looser mesenchyme whose cells are committed to become chondroblasts." [AEO:JB]
is_a: AEO:0000148 ! developing mesenchymal condensation
relationship: has_part CL:0000335 ! mesenchyme condensation cell

[Term]
id: AEO:0000151
name: loose mesenchyme tissue
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003151
def: "Mesenchyme whose cells are embedded in obvious amounts fo extracellular matrix." [AEO:JB]
is_a: AEO:0000145 ! mesenchymal tissue
relationship: has_part CL:0000057 ! fibroblast
relationship: has_part CL:0000327 ! extracellular matrix secreting cell

[Term]
id: AEO:0000152
name: migrating mesenchyme population
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003152
def: "Mesenchymal cells that are migrating." [AEO:JB]
is_a: AEO:0000145 ! mesenchymal tissue
relationship: has_part CL:0000134 ! mesenchymal cell

[Term]
id: AEO:0000153
name: mesenchymal tissue with stem cells
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003153
def: "Multi-tissue mesenchymal structure one of whose parts contains stem cells that can replace other parts." [AEO:JB]
is_a: AEO:0000187 ! multi-tissue structure with stem cells

[Term]
id: AEO:0000154
name: organism surfacef
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003154
def: "The collection of structures that form the exxtenal covering of the organism." [AEO:JB]
is_a: CARO:0000032 ! organism subdivision

[Term]
id: AEO:0000161
name: groove
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003161
alt_id: UBERON:0006846
alt_id: ZFA:0001690
def: "A furrow or an incomplete tube." [AEO:JB]
is_a: CARO:0000010 ! anatomical surface

[Term]
id: AEO:0000162
name: ridge
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003162
def: "A raised strip of tissue." [AEO:JB]
is_a: CARO:0000010 ! anatomical surface

[Term]
id: AEO:0000168
name: skeletal system
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003168
def: "The rigid support system for the body." [AEO:JB, VAO:0000027]
is_a: CARO:0000011 ! anatomical system

[Term]
id: AEO:0000169
name: embryo
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003169
alt_id: UBERON:0000922
alt_id: ZFA:0001105
def: "That part of the conceptus that will form the organism." [AEO:JB]
is_a: CARO:0000012 ! multi-cellular organism
relationship: part_of AEO:0000194 ! conceptus

[Term]
id: AEO:0000170
name: anlage
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003170
def: "Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue." [AEO:JB]
is_a: AEO:0000125 ! developing anatomical structure

[Term]
id: AEO:0000171
name: primordium
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003171
def: "Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue." [AEO:JB]
is_a: AEO:0000125 ! developing anatomical structure

[Term]
id: AEO:0000172
name: limb
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003172
def: "Appendage of an animal used for locomotion or grasping." [AEO:JB]
is_a: AEO:0000193 ! appendage

[Term]
id: AEO:0000173
name: surface sense organ
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003173
def: "Multicellular anatomical structure with largely bona fide boundary that extends outwards from or is part of the organism surface and transduces some sensory stimulus to the nervous system." [AEO:JB]
is_a: AEO:0000094 ! sense organ
relationship: part_of AEO:0000154 ! organism surfacef

[Term]
id: AEO:0000174
name: gender-specific anatomical structure
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003174
def: "A part of the body present only in a specific gender." [AEO:JB]
is_a: CARO:0000003 ! anatomical structure

[Term]
id: AEO:0000175
name: male anatomical structure
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003175
def: "A part of the body present only in males." [AEO:JB]
is_a: AEO:0000174 ! gender-specific anatomical structure

[Term]
id: AEO:0000176
name: female anatomical structure
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003176
def: "A part of the body present only in females." [AEO:JB]
is_a: AEO:0000174 ! gender-specific anatomical structure

[Term]
id: AEO:0000177
name: hermaphrodite anatomical structure
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003177
def: "A part of the body present only in hermaphrodites." [AEO:JB]
is_a: AEO:0000174 ! gender-specific anatomical structure

[Term]
id: AEO:0000178
name: fibrous joint
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003178
def: "A flexible joint between two bones that is made of unossified connective tissue." [AEO:JB]
is_a: AEO:0000081 ! matrix-based tissue
relationship: has_part CL:0002320 ! connective tissue cell
relationship: part_of AEO:0000168 ! skeletal system

[Term]
id: AEO:0000179
name: joint-associated cartilage
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003179
def: "The articular cartilage covering of the region of bone within a synoval joint." [AEO:JB]
is_a: AEO:0000087 ! cartilage
relationship: has_part CL:0000058 ! chondroblast
relationship: has_part CL:0000138 ! chondrocyte
relationship: part_of AEO:0000083 ! endochondral bone
relationship: part_of AEO:0000183 ! synovial joint

[Term]
id: AEO:0000180
name: non-joint-associated cartilage
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003180
def: "Cartilage that may provide the template for an endochondral bone or that may be a disinct entity in the skeleton." [AEO:JB]
is_a: AEO:0000087 ! cartilage
relationship: has_part CL:0000058 ! chondroblast
relationship: has_part CL:0000138 ! chondrocyte
relationship: part_of AEO:0000168 ! skeletal system

[Term]
id: AEO:0000181
name: synovial membrane
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003181
def: "The epithelial membrane between bone ends that forms the lateral borders of the synovial cavity and secretes synovial fluid." [AEO:JB]
is_a: CARO:0000069 ! multilaminar epithelium
relationship: has_part CL:0000079 ! stratified epithelial cell
relationship: part_of AEO:0000183 ! synovial joint

[Term]
id: AEO:0000183
name: synovial joint
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003183
def: "A joint connecting two or more bones with cartilage at the bone ends and a synovial membrane that secretes synovial fluid conecting the bones and sealing the synovial cavity." [AEO:JB]
is_a: CARO:0000055 ! multi-tissue structure
relationship: part_of AEO:0000168 ! skeletal system

[Term]
id: AEO:0000185
name: exoskeletal tissue
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003185
def: "A component of the exoskeleton." [AEO:JB]
is_a: AEO:0000081 ! matrix-based tissue
relationship: has_part CL:0000658 ! cuticle secreting cell
relationship: part_of AEO:0000168 ! skeletal system

[Term]
id: AEO:0000186
name: body cavity
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003186
alt_id: UBERON:0002323
def: "The cavity within the body that contains the visceral organs." [AEO:JB]
is_a: CARO:0000005 ! anatomical space

[Term]
id: AEO:0000187
name: multi-tissue structure with stem cells
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003187
def: "Multi-tissue structure one of whose parts contains stem cells that can replace other parts." [AEO:JB]
is_a: CARO:0000055 ! multi-tissue structure

[Term]
id: AEO:0000188
name: acellular fluid anatomical entity
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003188
def: "An acellular fluid portion of organism substance that is produced by the organism for some non-waste purpose." [AEO:JB]
is_a: CARO:0000040 ! acellular anatomical structure

[Term]
id: AEO:0000189
name: epithelial tissue with stem cells
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003189
def: "Multi-tissue epithelial structure one of whose parts contains stem cells that can replace other parts." [AEO:JB]
is_a: AEO:0000187 ! multi-tissue structure with stem cells

[Term]
id: AEO:0000192
name: anatomical surface feature
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003010
def: "Non-material anatomical entity of two dimensions, that is demarcated by anatomical lines or points on the external or internal surfaces of anatomical structures." [CARO:MAH]
synonym: "anatomical surface." RELATED []
is_obsolete: true

[Term]
id: AEO:0000193
name: appendage
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003193
alt_id: UBERON:0000026
def: "Organ or organ part that is attached to the body of an organism. For example a limb[GO, modified]. An appendage is an external body part, or natural prolongation, that protrudes from an organism's body, such as a vertebrate's limbs." [CARO:MAH]
is_a: CARO:0000032 ! organism subdivision

[Term]
id: AEO:0000194
name: conceptus
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003205
def: "All the products of the fertilized egg." [AEO:JB]
is_a: CARO:0000012 ! multi-cellular organism

[Term]
id: AEO:0000195
name: extraembryonic component
namespace: http://www.xspan.org/obo.owl#
def: "The part of the conceptus that may be lost before birth or will be discarded at birth, or when the embryo becomes an independent organism." [AEO:JB]
is_a: CARO:0000055 ! multi-tissue structure
relationship: part_of AEO:0000194 ! conceptus

[Term]
id: AEO:0000196
name: larval anatomical structure
namespace: http://www.xspan.org/obo.owl#
alt_id: HDAA2:0003126
def: "An anatomical structure present in the larval form of an animal." [AEO:JB]
is_a: AEO:0000125 ! developing anatomical structure
relationship: part_of AEO:0000126 ! larva

[Term]
id: AEO:0000198
name: antenna
namespace: http://www.xspan.org/obo.owl#
def: "A head-associated surface sense organ." [CARO:MAH]
is_a: AEO:0000173 ! surface sense organ
relationship: part_of AEO:0000106 ! head
relationship: part_of AEO:0000154 ! organism surfacef

[Term]
id: AEO:0000199
name: mucous membrane
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003234
def: "A membranous structure with more than one cell type, one or more of which secretes mucus, that lines body passages which communicate with the exterior." [AEO:JB]
synonym: "mucosa" RELATED []
is_a: CARO:0000055 ! multi-tissue structure

[Term]
id: AEO:0000200
name: regenerating anatomical structure
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003233
def: "An anatomical structure that, as part of its normal physiology, undergoes regeneration. Examples include endometrium and antlers." [AEO:JB]
is_a: CARO:0000003 ! anatomical structure

[Term]
id: AEO:0000201
name: afferent nerve
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003200
def: "A group of neurons that provides a nervous response from a tissue." [AEO:JB]
is_a: AEO:0000137 ! nerve
relationship: has_part CL:0000526 ! afferent neuron

[Term]
id: AEO:0000202
name: efferent nerve
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003231
def: "A group of neurons that provides a nervous signal to a tissue." [AEO:JB]
is_a: AEO:0000137 ! nerve
relationship: has_part CL:0000527 ! efferent neuron

[Term]
id: AEO:0000203
name: syncytium
namespace: http://www.xspan.org/obo.owl#
alt_id: HDAA2:0003248
def: "An anatomical entity consisting of a single or a few multinucleated structures." [AEO.:JB]
is_a: CARO:0000043 ! simple tissue
relationship: has_part CL:0000228 ! multinucleate cell

[Term]
id: AEO:0000204
name: pit
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:003249
def: "An roughly circular indentation in a surface." [AEO:JB]
is_a: CARO:0000010 ! anatomical surface

[Term]
id: AEO:0000205
name: protuberance
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003250
def: "A roughly circular bulge in a surface." [AEO:JB]
is_a: CARO:0000010 ! anatomical surface

[Term]
id: AEO:0000206
name: migrating epithelium
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003251
def: "An epithelium that extends its surface area by peripheral movement." [AEO:JB]
is_a: CARO:0000066 ! epithelium
relationship: has_part CL:0000066 ! epithelial cell

[Term]
id: AEO:0000207
name: blood vessel
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003252
def: "An epithelial tube that transports blood." [AEO:JB]
is_a: AEO:0000114 ! epithelial tube
relationship: has_part CL:0000071 ! blood vessel endothelial cell

[Term]
id: AEO:0000208
name: artery
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003253
def: "An epithelial tube that transports blood away from the heart." [AEO:JB]
is_a: AEO:0000207 ! blood vessel
relationship: has_part CL:0000071 ! blood vessel endothelial cell

[Term]
id: AEO:0000209
name: vein
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003254
def: "An epithelial tube that transports blood towards the heart." [AEO:JB]
is_a: AEO:0000207 ! blood vessel
relationship: has_part CL:0000071 ! blood vessel endothelial cell

[Term]
id: AEO:0000210
name: row
namespace: http://www.xspan.org/obo.owl#
alt_id: FBbt:00100152
alt_id: HDAA2:0003255
def: "Anatomical group whose component structures are arranged in a row." [DBft:DOS]
is_a: CARO:0000054 ! anatomical group

[Term]
id: AEO:0000211
name: non-connected developing functional system
namespace: http://www.xspan.org/obo.owl#
alt_id: FBbt:0004003
alt_id: HDAA2:0003256
def: "The sum of all the anlagen and primordia that will develop into a single functional system." [FBbt:DOS]
is_a: AEO:0000125 ! developing anatomical structure
is_a: CARO:0000041 ! anatomical cluster

[Term]
id: AEO:0000212
name: sclerotome
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003257
def: "The mesenchymal derivative of a somite that will migrate to surround the neural tube and form vertebrae." [AEO:JB]
is_a: AEO:0000152 ! migrating mesenchyme population
is_a: AEO:0001016 ! developing mesenchymal structure
relationship: has_part CL:0000134 ! mesenchymal cell

[Term]
id: AEO:0000213
name: bone condensation
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003258
def: "A delimited region of osteoblasts representing the early stages of bone formation." [AEO:JB]
is_a: AEO:0000148 ! developing mesenchymal condensation
relationship: has_part CL:0000062 ! osteoblast

[Term]
id: AEO:0000214
name: dermomyotome
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003259
def: "The bilaminar epithelium formed from the myotome and dermatome." [AEO:JB]
is_a: AEO:0000132 ! transitional anatomical structure
is_a: CARO:0000069 ! multilaminar epithelium
relationship: has_part CL:0000075 ! columnar/cuboidal epithelial cell

[Term]
id: AEO:0000215
name: open cavity
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003078
def: "A volume that is mainly bounded but has an opening to another cavity or to the outside." [JB:AEO]
is_a: AEO:0000221 ! open anatomical space

[Term]
id: AEO:0000216
name: epithelial cord
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0004052
def: "A cord of epithelial cells without a lumen and usually several cells thick." [JB:AEO]
is_a: CARO:0000066 ! epithelium
relationship: has_part CL:0000079 ! stratified epithelial cell

[Term]
id: AEO:0000217
name: migrating developing tissue
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0004053
def: "A simple coherent tissue or a localized population of similar cells that are actively migrating." [JB:AEO]
is_a: AEO:0000125 ! developing anatomical structure

[Term]
id: AEO:0000218
name: developing epithelial placode
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003112
def: "A domain of columnar epithelium in an embryo that represents the early stage of the development of the epithelial component of a new anatomical structure." [JB:AEO]
is_a: AEO:0001007 ! developing epithelium
relationship: has_part CL:0000075 ! columnar/cuboidal epithelial cell

[Term]
id: AEO:0000219
name: vascular plexus
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0004112
def: "A network of interlinked veins." [JB:AEO]
is_a: AEO:0000118 ! epithelial plexus
relationship: has_part CL:0000071 ! blood vessel endothelial cell

[Term]
id: AEO:0000220
name: tooth
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0004605
def: "Each of a set of hard, bony enamel-coated structures in the jaws of most vertebrates, used for biting and chewing." [JB:AEO]
is_a: CARO:0000055 ! multi-tissue structure

[Term]
id: AEO:0000221
name: open anatomical space
namespace: http://www.xspan.org/obo.owl#
def: "An anatomical space with at least one opening to another space or the exterior." [JB:AEO]
is_a: CARO:0000005 ! anatomical space

[Term]
id: AEO:0000222
name: enclosed anatomical space
namespace: http://www.xspan.org/obo.owl#
def: "An anatomical space with no opening to another space or to the exterior." [JB:AEO]
is_a: CARO:0000005 ! anatomical space

[Term]
id: AEO:0000493
name: fat tissue
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003120
def: "Tissue that is predominantly made of fat cells." [AEO:JB]
is_a: CARO:0000043 ! simple tissue
relationship: has_part CL:0000136 ! fat cell

[Term]
id: AEO:0001000
name: sensory ganglion
namespace: http://www.xspan.org/obo.owl#
def: "A ganglion containing sensory neurons." [JB:AEO]
is_a: AEO:0000135 ! ganglion
relationship: has_part CL:0000101 ! sensory neuron
relationship: has_part CL:0000243 ! glial cell (sensu Vertebrata)
relationship: has_part CL:0002573 ! Schwann cell

[Term]
id: AEO:0001001
name: autonomic ganglion
namespace: http://www.xspan.org/obo.owl#
def: "A ganglion that is part of the autonomic nervous system." [JB:AEO]
is_a: AEO:0000135 ! ganglion
relationship: has_part CL:0000107 ! autonomic neuron
relationship: has_part CL:0000243 ! glial cell (sensu Vertebrata)
relationship: has_part CL:0000526 ! afferent neuron
relationship: has_part CL:0000527 ! efferent neuron
relationship: has_part CL:0002573 ! Schwann cell

[Term]
id: AEO:0001002
name: capillary bed
namespace: http://www.xspan.org/obo.owl#
def: "A localized group of blood capillaries." [JB:AEO]
is_a: AEO:0000118 ! epithelial plexus

[Term]
id: AEO:0001003
name: acellular extracellular matrix
namespace: http://www.xspan.org/obo.owl#
def: "An acellular structure typically composed of collagen, glycoproteins and glycosaminoglycans." [JB:AEO]
is_a: CARO:0000040 ! acellular anatomical structure

[Term]
id: AEO:0001004
name: fin
namespace: http://www.xspan.org/obo.owl#
def: "A flattened appendage on a marine animal." [JB:AEO, VAO:0000099]
is_a: AEO:0000193 ! appendage

[Term]
id: AEO:0001005
name: secretion
namespace: http://www.xspan.org/obo.owl#
alt_id: UBERON:0000456
def: "A non-cellular substance released by a cell, gland or tissue." [JB:AEO]
is_a: CARO:0000004 ! non-tissue substance

[Term]
id: AEO:0001006
name: excreta
namespace: http://www.xspan.org/obo.owl#
alt_id: UBERON:0000174
def: "Excreta are bodily fluids consisting of waste matter, such as sweat or feces, discharged from the body." [JB:AEO]
is_a: CARO:0000004 ! non-tissue substance

[Term]
id: AEO:0001007
name: developing epithelium
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0004653
def: "An epithelium within an embryo or larva that is undergoing a major developmental change." [AEO:JB]
is_a: AEO:0000125 ! developing anatomical structure
is_a: CARO:0000066 ! epithelium

[Term]
id: AEO:0001008
name: neuroepithelium
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0004654
def: "An embryonic or larval epithelium that is committed to form part of the nervous system." [AEO:JB]
is_a: AEO:0001007 ! developing epithelium
relationship: has_part CL:0000075 ! columnar/cuboidal epithelial cell

[Term]
id: AEO:0001009
name: proliferating neuroepithelium
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0004655
def: "An epithelium that is undergoing proliferation to provide large numbers of neuronal cells." [AEO:JB]
is_a: AEO:0001008 ! neuroepithelium
relationship: has_part CL:0000075 ! columnar/cuboidal epithelial cell

[Term]
id: AEO:0001010
name: differentiating neuroepithelium
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0004656
def: "A neuroepithelium some of whose cells are undergoing terminal differentiation to become neuronal cells." [AEO:JB]
is_a: AEO:0001008 ! neuroepithelium
relationship: has_part CL:0000031 ! neuroblast
relationship: has_part CL:0000468 ! neuroglioblast

[Term]
id: AEO:0001011
name: neuronal white matter
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0004657
def: "Neuronal tissue composed predominantly of axons." [AEO:JB]
is_a: AEO:0000123 ! neural tissue

[Term]
id: AEO:0001012
name: neuronal grey matter
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0004658
def: "A neuronal tissue composed predominantly of nerve bodies and neuronal support cells." [AEO:JB]
is_a: AEO:0000123 ! neural tissue

[Term]
id: AEO:0001013
name: neuronal column
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0004659
def: "An extended columnar domain of predominantly neuronal tissue in the central nervous system." [AEO:JB]
is_a: AEO:0001012 ! neuronal grey matter
relationship: has_part CL:0000127 ! astrocyte
relationship: has_part CL:0000128 ! oligodendrocyte
relationship: has_part CL:0000129 ! microglial cell

[Term]
id: AEO:0001014
name: differentiating neuronal condensation
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0004660
def: "A compact group of cells differentiating to become a ganglion or a neuronal nucleus." [AEO:JB]
is_a: AEO:0000125 ! developing anatomical structure
relationship: has_part CL:0000031 ! neuroblast
relationship: has_part CL:0000468 ! neuroglioblast

[Term]
id: AEO:0001015
name: somite
namespace: http://www.xspan.org/obo.owl#
def: "An epithelial ball that forms from paraxial mesoderm." [JB:AEO]
is_a: AEO:0000119 ! epithelial vesicle

[Term]
id: AEO:0001016
name: developing mesenchymal structure
namespace: http://www.xspan.org/obo.owl#
def: "A mesenchyme-derived anatomical entity undergoing a transtion to become another structure." [AEO:JB]
is_a: AEO:0000125 ! developing anatomical structure

[Term]
id: AEO:0001017
name: dermatome
namespace: http://www.xspan.org/obo.owl#
def: "A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells." [AEO:JB]
is_a: AEO:0000217 ! migrating developing tissue
is_a: AEO:0001016 ! developing mesenchymal structure

[Term]
id: AEO:0001018
name: myotome
namespace: http://www.xspan.org/obo.owl#
def: "A transitional population of migrating mesenchymal cells that derive from somites and that will become muscle cells." [AEO:JB]
is_a: AEO:0000217 ! migrating developing tissue
is_a: AEO:0001016 ! developing mesenchymal structure

[Term]
id: AEO:0001019
name: developing germ cell population
namespace: http://www.xspan.org/obo.owl#
def: "A germ cell population that has not undergone meiosis." [AEO:JB]
is_a: AEO:0000125 ! developing anatomical structure

[Term]
id: AEO:0001020
name: reproductive cell population
namespace: http://www.xspan.org/obo.owl#
def: "A population of cells that are predominantly immature or mature germ cells." [AEO:JB]
is_a: CARO:0000043 ! simple tissue
relationship: has_part CL:0000039 ! germ line cell

[Term]
id: AEO:0001021
name: stem cell population
namespace: http://www.xspan.org/obo.owl#
def: "A group of cells capable of regenerating themselves and also of producing one or more populations of differentiated cells." [AEO:JB]
is_a: CARO:0000043 ! simple tissue

[Term]
id: CARO:0000000
name: anatomical entity
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003000
alt_id: UBERON:0001062
def: "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species." [CARO:MAH]

[Term]
id: CARO:0000003
name: anatomical structure
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003003
alt_id: UBERON:0000061
def: "Material anatomical entity that has inherent 3D shape and is generated by coordinated expression of the organism's own genome." [CARO:MAH]
is_a: CARO:0000006 ! material anatomical entity

[Term]
id: CARO:0000004
name: non-tissue substance
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003004
alt_id: UBERON:0000463
def: "Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body." [CARO:MAH]
synonym: "portion of organism substance" RELATED []
is_a: CARO:0000006 ! material anatomical entity

[Term]
id: CARO:0000005
name: anatomical space
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003005
alt_id: UBERON:0000464
def: "Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures." [CARO:MAH]
is_a: CARO:0000007 ! immaterial anatomical entity

[Term]
id: CARO:0000006
name: material anatomical entity
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003006
alt_id: UBERON:0000465
def: "Anatomical entity that has mass." [CARO:MAH]
is_a: CARO:0000000 ! anatomical entity

[Term]
id: CARO:0000007
name: immaterial anatomical entity
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003007
alt_id: UBERON:0000466
def: "Anatomical entity that has no mass." [CARO:MAH]
is_a: CARO:0000000 ! anatomical entity

[Term]
id: CARO:0000008
name: anatomical line
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003008
def: "Non-material anatomical entity of one dimension, which forms a boundary of an anatomical surface or is a modulation of an anatomical surface." [CARO:MAH]
is_a: CARO:0000007 ! immaterial anatomical entity

[Term]
id: CARO:0000009
name: anatomical point
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003009
def: "Non-material anatomical entity of zero dimension, which forms a boundary of an anatomical line or surface." [CARO:MAH]
is_a: CARO:0000007 ! immaterial anatomical entity

[Term]
id: CARO:0000010
name: anatomical surface
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003192
alt_id: UBERON:0000015
def: "Non-material anatomical entity of two dimensions, that is demarcated by anatomical lines or points on the external or internal surfaces of anatomical structures." [CARO:MAH]
is_a: CARO:0000007 ! immaterial anatomical entity

[Term]
id: CARO:0000011
name: anatomical system
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003011
def: "Anatomical group that is has as its parts distinct anatomical structures interconnected by anatomical structures at a lower level of granularity." [CARO:MAH]
is_a: CARO:0000054 ! anatomical group

[Term]
id: CARO:0000012
name: multi-cellular organism
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003191
alt_id: UBERON:0000468
def: "Anatomical structure that is an individual member of a species and consists of more than one cell." [JB:DEF]
is_a: CARO:0000003 ! anatomical structure

[Term]
id: CARO:0000013
name: cell
namespace: http://www.xspan.org/obo.owl#
def: "Anatomical structure that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." [CARO:MAH]
is_a: CARO:0000003 ! anatomical structure

[Term]
id: CARO:0000014
name: cell component
namespace: http://www.xspan.org/obo.owl#
def: "Anatomical structure that is a direct part of the cell." [CARO:MAH]
is_a: CARO:0000003 ! anatomical structure
relationship: part_of CARO:0000013 ! cell

[Term]
id: CARO:0000019
name: compound organ component
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003019
def: "Multi-tissue structure that is part of a compound organ." [CARO:MAH]
is_a: CARO:0000055 ! multi-tissue structure
relationship: part_of CARO:0000024 ! compound organ

[Term]
id: CARO:0000021
name: simple organ
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003190
def: "Multi-tissue structure that is not part of a compound organ." [CARO:MAH]
is_a: CARO:0000055 ! multi-tissue structure

[Term]
id: CARO:0000024
name: compound organ
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003024
def: "Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types." [CARO:MAH]
is_a: CARO:0000003 ! anatomical structure

[Term]
id: CARO:0000027
name: male organism
namespace: http://www.xspan.org/obo.owl#
def: "Gonochoristic organism that can produce male gametes." [CARO:MAH]
is_a: CARO:0000048 ! gonochoristic organism

[Term]
id: CARO:0000028
name: female organism
namespace: http://www.xspan.org/obo.owl#
def: "Gonochoristic organism that can produce female gametes." [CARO:MAH]
is_a: CARO:0000048 ! gonochoristic organism

[Term]
id: CARO:0000029
name: hermaphroditic organism
namespace: http://www.xspan.org/obo.owl#
def: "Multi-cellular organism that can produce both male and female gametes." [CARO:MAH]
synonym: "dioecious organism" RELATED []
is_a: CARO:0000012 ! multi-cellular organism

[Term]
id: CARO:0000032
name: organism subdivision
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003032
alt_id: UBERON:0000475
def: "Anatomical structure which is a primary subdivision of whole organism. The mereological sum of these is the whole organism." [CARO:MAH]
is_a: CARO:0000003 ! anatomical structure

[Term]
id: CARO:0000040
name: acellular anatomical structure
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003040
alt_id: UBERON:0000476
def: "Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue." [CARO:MAH]
is_a: CARO:0000003 ! anatomical structure

[Term]
id: CARO:0000041
name: anatomical cluster
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003041
alt_id: UBERON:0000477
def: "Anatomical group that has its parts adjacent to one another. Anatomical structure, which has as its parts a heterogeneous collection of organs, organ parts, cells or body part subdivisions that are adjacent to, or continuous with one another; does not constitute an organ, organ system or organ system subdivision, or body part or body part subdivision." [CARO:MAH]
is_a: CARO:0000054 ! anatomical group

[Term]
id: CARO:0000042
name: extraembryonic structure
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003042
alt_id: UBERON:0000478
def: "Anatomical structure that is contiguous with the embryo and is comprised of portions of tissue or cells that will not contribute to the embryo." [CARO:MAH]
is_a: CARO:0000003 ! anatomical structure

[Term]
id: CARO:0000043
name: simple tissue
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003043
alt_id: UBERON:0000479
def: "Anatomical structure, that consists of similar cells and intercellular matrix, aggregated according to genetically determined spatial relationships." [CARO:MAH]
synonym: "portion of tissue." RELATED []
is_a: CARO:0000003 ! anatomical structure

[Term]
id: CARO:0000045
name: sequential hermaphroditic organism
namespace: http://www.xspan.org/obo.owl#
def: "Hermaphroditic organism that produces gametes first of one sex, and then later of the other sex." [CARO:MAH]
synonym: "consecutive hermaphroditic organism" RELATED []
is_a: CARO:0000029 ! hermaphroditic organism

[Term]
id: CARO:0000046
name: synchronous hermaphroditic organism
namespace: http://www.xspan.org/obo.owl#
def: "Hermaphroditic organism that produces both male and female gametes at the same time." [CARO:MAH]
synonym: "serially hermaphroditic organism" RELATED []
is_a: CARO:0000029 ! hermaphroditic organism

[Term]
id: CARO:0000048
name: gonochoristic organism
namespace: http://www.xspan.org/obo.owl#
def: "Multi-cellular organism that has male and female sexes." [CARO:MAH]
synonym: "monoecious organism" RELATED []
is_a: CARO:0000012 ! multi-cellular organism

[Term]
id: CARO:0000049
name: protandrous hermaphroditic organism
namespace: http://www.xspan.org/obo.owl#
def: "Sequential hermaphroditic organism that produces gametes first of the male sex, and then later of the female sex." [CARO:MAH]
is_a: CARO:0000045 ! sequential hermaphroditic organism

[Term]
id: CARO:0000050
name: protogynous hermaphroditic organism
namespace: http://www.xspan.org/obo.owl#
def: "Sequential hermaphroditic organism that produces gametes first of the female sex, and then later of the male sex." [CARO:MAH]
is_a: CARO:0000045 ! sequential hermaphroditic organism

[Term]
id: CARO:0000054
name: anatomical group
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003054
alt_id: UBERON:0000480
def: "Anatomical structure consisting of at least two non-overlapping organs, multi-tissue aggregates or portion of tissues or cells of different types that does not constitute an organism, organ, multi-tissue aggregate, or portion of tissue." [CARO:MAH]
is_a: CARO:0000003 ! anatomical structure

[Term]
id: CARO:0000055
name: multi-tissue structure
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003055
alt_id: UBERON:0000481
def: "Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types." [CARO:MAH]
is_a: CARO:0000003 ! anatomical structure

[Term]
id: CARO:0000062
name: cell space
namespace: http://www.xspan.org/obo.owl#
def: "Anatomical space that is part of a cell." [CARO:mah]
is_a: CARO:0000005 ! anatomical space

[Term]
id: CARO:0000063
name: asexual organism
namespace: http://www.xspan.org/obo.owl#
def: "Multi-cellular organism that does not produce gametes." [CARO:MAH]
is_a: CARO:0000012 ! multi-cellular organism

[Term]
id: CARO:0000064
name: single cell organism
namespace: http://www.xspan.org/obo.owl#
def: "Cell that is an individual member of a species." [CARO:MAH]
is_a: CARO:0000013 ! cell

[Term]
id: CARO:0000065
name: basal lamina
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003065
def: "Acellular anatomical structure that consists of a thin sheet of fibrous proteins that underlie and support the cells of an epithelium. It separates the cells of an epithelium from any underlying tissue." [CARO:MAH]
is_a: CARO:0000040 ! acellular anatomical structure
relationship: part_of CARO:0000066 ! epithelium

[Term]
id: CARO:0000066
name: epithelium
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003066
def: "Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina." [CARO:MAH]
is_a: CARO:0000043 ! simple tissue

[Term]
id: CARO:0000067
name: simple cuboidal epithelium
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003067
def: "Unilaminar epithelium that consists of a single layer of cuboidal cells." [CARO:MAH]
is_a: CARO:0000073 ! unilaminar epithelium
relationship: has_part CL:0000075 ! columnar/cuboidal epithelial cell

[Term]
id: CARO:0000068
name: columnar epithelium
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003068
def: "Unilaminar epithelium that consists of a single layer of columnar cells." [CARO:MAH]
is_a: CARO:0000073 ! unilaminar epithelium

[Term]
id: CARO:0000069
name: multilaminar epithelium
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003069
def: "Epithelium that consists of more than one layer of epithelial cells." [CARO:MAH]
is_a: CARO:0000066 ! epithelium

[Term]
id: CARO:0000070
name: simple squamous epithelium
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003070
def: "Unilaminar epithelium that consists of a single layer of squamous cells." [CARO:MAH]
is_a: CARO:0000073 ! unilaminar epithelium
relationship: has_part CL:0000076 ! squamous epithelial cell

[Term]
id: CARO:0000071
name: atypical epithelium
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003071
def: "Epithelium that consists of epithelial cells not arranged in one ore more layers." [CARO:MAH]
is_a: CARO:0000066 ! epithelium
relationship: has_part CL:0000066 ! epithelial cell

[Term]
id: CARO:0000072
name: cavitated compound organ
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003072
def: "Compound organ that contains one or more macroscopic anatomical spaces." [CARO:MAH]
is_a: CARO:0000024 ! compound organ

[Term]
id: CARO:0000073
name: unilaminar epithelium
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003073
def: "Epithelium that consists of a single layer of epithelial cells." [CARO:MAH]
is_a: CARO:0000066 ! epithelium

[Term]
id: CARO:0000074
name: solid compound organ
namespace: http://www.xspan.org/obo.owl#
alt_id: EHDAA2:0003074
def: "Compound organ that does not contain macroscopic anatomical spaces." [CARO:MAH]
is_a: CARO:0000024 ! compound organ

[Term]
id: CARO:0000077
name: epithelial cell
namespace: http://www.xspan.org/obo.owl#
def: "Cell which has as its part a cytoskeleton that allows for tight cell to cell contact and which has apical-basal cell polarity." [CARO:MAH, CL:0000066]
is_a: CARO:0000013 ! cell

[Term]
id: CL:0000000
name: cell
namespace: cell
def: "Anatomical structure that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." [CARO:mah]

[Term]
id: CL:0000003
name: cell in vivo
namespace: cell
is_a: CL:0000000 ! cell

[Term]
id: CL:0000012
name: cell by class
namespace: cell
is_a: CL:0000003 ! cell in vivo

[Term]
id: CL:0000015
name: male germ cell
namespace: cell
def: "A germline cell that contributes to the development of the oocyte by transferring cytoplasm directly to oocyte." [GOC:tfm, PMID:15848391]
synonym: "nurse cell" RELATED []
is_a: CL:0000586 ! germ cell

[Term]
id: CL:0000021
name: female germ cell
namespace: cell
def: "Female germ cell is a germ cell that supports female gamete production." [GOC:tfm, PMID:11023867, PMID:20454446]
is_a: CL:0000586 ! germ cell

[Term]
id: CL:0000029
name: neuron neural crest derived
namespace: cell
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000031
name: neuroblast
namespace: cell
is_a: CL:0000055 ! non-terminally differentiated cell

[Term]
id: CL:0000034
name: stem cell
namespace: cell
def: "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:tfm, MESH:A.11.872]
is_a: CL:0000144 ! cell by function

[Term]
id: CL:0000039
name: germ line cell
namespace: cell
def: "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring." [GOC:tfm, ISBN:0721662544]
comment: Originally this term had some plant germ line cell children
is_a: CL:0000144 ! cell by function

[Term]
id: CL:0000055
name: non-terminally differentiated cell
namespace: cell
def: "A precursor cell with a limited number of potential fates." [SANBI:mhl]
synonym: "blast cell" RELATED []
is_a: CL:0000012 ! cell by class

[Term]
id: CL:0000057
name: fibroblast
namespace: cell
def: "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." [http://63.198.234.228/OpenFMA/Fibroblast.html, ISBN:0517223651, MESH:A.11.329.228]
is_a: CL:0002320 ! connective tissue cell

[Term]
id: CL:0000058
name: chondroblast
namespace: cell
def: "An immature cartilage-producing cell found in growing cartilage." [GOC:tfm, ISBN:0618947256]
synonym: "chrondoplast" RELATED []
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0000667 ! collagen secreting cell

[Term]
id: CL:0000062
name: osteoblast
namespace: cell
def: "A bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone." [MESH:A.11.329.629]
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0002320 ! connective tissue cell

[Term]
id: CL:0000063
name: cell by histology
namespace: cell
def: "A classification of cells by their microscopic appearance." [FB:ma, GOC:tfm]
is_a: CL:0000012 ! cell by class

[Term]
id: CL:0000066
name: epithelial cell
namespace: cell
def: "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina." [FB:ma, GOC:tfm, MESH:A.11.436]
synonym: "Epitheliocyte" RELATED []
is_a: CL:0000063 ! cell by histology

[Term]
id: CL:0000068
name: duct epithelial cell
namespace: cell
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000071
name: blood vessel endothelial cell
namespace: cell
def: "An endothelial cell that lines the vasculature." [GOC:tfm]
synonym: "Cuboidal endothelial cell of vascular tree" RELATED []
is_a: CL:0000076 ! squamous epithelial cell

[Term]
id: CL:0000075
name: columnar/cuboidal epithelial cell
namespace: cell
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000076
name: squamous epithelial cell
namespace: cell
is_a: CL:0000066 ! epithelial cell

[Term]
id: CL:0000079
name: stratified epithelial cell
namespace: cell
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000080
name: circulating cell
namespace: cell
def: "A cell which moves among different tissues of the body, via blood, lymph, or other medium." [GOC:add]
is_a: CL:0000144 ! cell by function

[Term]
id: CL:0000081
name: blood cell
namespace: cell
def: "A cell found predominately in the blood." [GOC:add, GOC:tfm]
is_a: CL:0000988 ! hematopoietic cell

[Term]
id: CL:0000095
name: neuron associated cell
namespace: cell
is_a: CL:0002319 ! neural cell

[Term]
id: CL:0000099
name: interneuron
namespace: cell
def: "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions." [GOC:tfm, MESH:A.08.663.358]
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000101
name: sensory neuron
namespace: cell
def: "Any neuron having a sensory function; an afferent neuron conveying sensory impulses." [ISBN:0721662544]
is_a: CL:0000526 ! afferent neuron

[Term]
id: CL:0000107
name: autonomic neuron
namespace: cell
def: "A neruon whose cell body is within an autonomic ganglion." [GOC:tfm]
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000125
name: glial cell
namespace: cell
def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." [MESH:A.08.637]
synonym: "neuroglia" RELATED []
synonym: "neuroglial cell" RELATED []
is_a: CL:0000095 ! neuron associated cell

[Term]
id: CL:0000126
name: macroglial cell
namespace: cell
def: "A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together." [GOC:tfm, ISBN:0721662544]
synonym: "Macrogliocyte" RELATED []
is_a: CL:0000243 ! glial cell (sensu Vertebrata)

[Term]
id: CL:0000127
name: astrocyte
namespace: cell
def: "A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury." [GOC:_tfm, GOC:dsd, MESH:A.08.637.200, MESH:D001253, PMID:11746784, PMID:12162730, PMID:12898703, PMID:20942978]
synonym: "astrocytic glia" RELATED []
is_a: CL:0000128 ! oligodendrocyte

[Term]
id: CL:0000128
name: oligodendrocyte
namespace: cell
def: "A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system." [MESH:A.08.637.600]
synonym: "oligodendroglia" RELATED []
is_a: CL:0000126 ! macroglial cell

[Term]
id: CL:0000129
name: microglial cell
namespace: cell
def: "A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0721601464, MESH:D017628, PMID:11517395, PMID:12430718, PMID:14561199, PMID:14612429, PMID:16177057, PMID:19461673, PMID:2089275]
synonym: "brain macrophage" RELATED []
synonym: "brain-resident macrophage" RELATED []
synonym: "hortega cells" RELATED [http://www.copewithcytokines.de/]
synonym: "MF.microglia.CNS" RELATED []
synonym: "microglia" RELATED []
synonym: "microgliocyte" RELATED [http://www.copewithcytokines.de/]
is_a: CL:0000243 ! glial cell (sensu Vertebrata)

[Term]
id: CL:0000134
name: mesenchymal cell
namespace: cell
alt_id: CL:0002452
def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. This cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro.  Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." [FB:ma, GOC:dsd, http://en.wikipedia.org/wiki/Mesenchymal_stem_cell, http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells, PMCID:PMC2613570, PMID:10102814j, PMID:16923606, PMID:_17986482, PMID:_19960544]
synonym: "BMSC" RELATED []
synonym: "bone marrow stromal cells" RELATED []
synonym: "CFU-F" RELATED []
synonym: "colony-forming unit-fibroblast" RELATED []
synonym: "marrow stromal cells" RELATED [PMID:11378515]
synonym: "mesenchymal precursor cell" RELATED []
synonym: "mesenchymal progenitor cells" RELATED [MESH:D044982]
synonym: "mesenchymal stem cell" RELATED []
synonym: "mesenchymal stromal cell" RELATED []
synonym: "mesenchymal stromal cells" RELATED []
synonym: "MSC" RELATED [PMID:11378515]
synonym: "Stem Cells, Mesenchymal" RELATED [MESH:D044982]
is_a: CL:0000063 ! cell by histology

[Term]
id: CL:0000136
name: fat cell
namespace: cell
alt_id: CL:0000450
def: "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides." [MESH:A.11.329.114]
synonym: "adipocyte" RELATED []
synonym: "adipose cell" RELATED []
is_a: CL:0002320 ! connective tissue cell

[Term]
id: CL:0000138
name: chondrocyte
namespace: cell
def: "Polymorphic cell that form cartilage." [MESH:A.11.329.171]
synonym: "cartilage cell" RELATED []
is_a: CL:0000667 ! collagen secreting cell

[Term]
id: CL:0000144
name: cell by function
namespace: cell
def: "A classification of cells by their primary end goal or behavior." [FB:ma]
is_a: CL:0000012 ! cell by class

[Term]
id: CL:0000151
name: secretory cell
namespace: cell
def: "A cell that specializes in controlled release of one or more substances." [GOC:tfm, ISBN:0721662544]
is_a: CL:0000144 ! cell by function

[Term]
id: CL:0000165
name: neuroendocrine cell
namespace: cell
def: "An endocrine cell that has the specialized function to produce and secrete hormones in response to neuronal signals." [MESH:A.06.688]
synonym: "neurosecretory cell" RELATED []
is_a: CL:0000393 ! electrically responsive cell

[Term]
id: CL:0000187
name: muscle cell
namespace: cell
def: "A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [MESH:A.11.620]
synonym: "myocyte" RELATED []
is_a: CL:0000393 ! electrically responsive cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000188
name: skeletal muscle cell
namespace: cell
def: "A somatic cell located in skeletal muscle." [GOC:tfm]
is_a: CL:0000187 ! muscle cell

[Term]
id: CL:0000192
name: smooth muscle cell
namespace: cell
alt_id: CL:0000191
def: "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)." [MESH:A.11.620.520, MESH:D032389, PMID:9315361]
synonym: "myocytes, smooth muscle" RELATED [MESH:D032389]
synonym: "non-striated muscle cell" RELATED []
synonym: "SMCs" RELATED [PMID:9315361]
synonym: "smooth muscle fiber" RELATED []
is_a: CL:0000187 ! muscle cell

[Term]
id: CL:0000196
name: flight muscle cell
namespace: cell
is_a: CL:0000187 ! muscle cell

[Term]
id: CL:0000211
name: electrically active cell
namespace: cell
def: "A cell whose function is determined by the generation or the reception of an electric signal." [FB:ma]
is_a: CL:0000144 ! cell by function

[Term]
id: CL:0000224
name: cell by nuclear number
namespace: cell
def: "A classification of cells by the number of their nuclei." [FB:ma, GOC:tfm]
is_a: CL:0000012 ! cell by class

[Term]
id: CL:0000228
name: multinucleate cell
namespace: cell
def: "A cell with more than one nucleus." [FB:ma]
synonym: "syncitium" RELATED []
synonym: "syncytial cell" RELATED []
synonym: "syncytium" RELATED []
is_a: CL:0002242 ! nucleate cell

[Term]
id: CL:0000243
name: glial cell (sensu Vertebrata)
namespace: cell
def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear." [MESH:A.08.637]
is_a: CL:0000125 ! glial cell

[Term]
id: CL:0000327
name: extracellular matrix secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell
is_a: CL:0000499 ! stromal cell

[Term]
id: CL:0000335
name: mesenchyme condensation cell
namespace: cell
def: "A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors." [GOC:tfm, PMID:5025404]
is_a: CL:0000134 ! mesenchymal cell

[Term]
id: CL:0000393
name: electrically responsive cell
namespace: cell
def: "A cell whose function is determined by its response to an electric signal." [FB:ma]
is_a: CL:0000211 ! electrically active cell

[Term]
id: CL:0000414
name: cell by ploidy
namespace: cell
def: "A classification of cells by the number of haploid genome equivalents of their nucleus or nuclei." [FB:ma, GOC:tfm]
is_a: CL:0000012 ! cell by class

[Term]
id: CL:0000444
name: obliquely striated muscle cell
namespace: cell
is_a: CL:0000737 ! striated muscle cell

[Term]
id: CL:0000445
name: apoptosis fated cell
namespace: cell
is_a: CL:0000144 ! cell by function

[Term]
id: CL:0000468
name: neuroglioblast
namespace: cell
is_a: CL:0000055 ! non-terminally differentiated cell

[Term]
id: CL:0000499
name: stromal cell
namespace: cell
def: "A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere." [GOC:tfm, MESH:A.11.329.830]
is_a: CL:0002320 ! connective tissue cell

[Term]
id: CL:0000525
name: syncytiotrophoblast cell
namespace: cell
def: "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo. It It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy." [GOC:tfm, ISBN:0323052908]
synonym: "plasmidotrophoblast" RELATED []
synonym: "syncytial trophoblast" RELATED []
synonym: "syntrophoblast" RELATED []
is_a: CL:0000228 ! multinucleate cell

[Term]
id: CL:0000526
name: afferent neuron
namespace: cell
def: "A neuron which conveys sensory information centrally from the periphery." [GOC:tfm, MESH:A.08.663.650]
synonym: "input neuron" RELATED []
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000527
name: efferent neuron
namespace: cell
def: "A neuron which sends impulses peripherally to activate muscles or secretory cells." [MESH:A.08.663.655]
synonym: "output neuron" RELATED []
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000540
name: neuron
namespace: cell
def: "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [MESH:A.08.663, MESH:D009474]
synonym: "nerve cell" RELATED []
is_a: CL:0000393 ! electrically responsive cell

[Term]
id: CL:0000586
name: germ cell
namespace: cell
def: "The reproductive cell in multicellular organisms." [MESH:A.05.360.490]
is_a: CL:0000039 ! germ line cell

[Term]
id: CL:0000658
name: cuticle secreting cell
namespace: cell
def: "An epithelial cell that secretes cuticle." [GOC:tfm]
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000327 ! extracellular matrix secreting cell

[Term]
id: CL:0000667
name: collagen secreting cell
namespace: cell
def: "An extracellular matrix secreting cell that secretes collagen." [GOC:tfm]
is_a: CL:0000327 ! extracellular matrix secreting cell

[Term]
id: CL:0000670
name: primordial germ cell
namespace: cell
def: "A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells." [GOC:tfm, PMID:1381289]
synonym: "Gonocyte" RELATED []
synonym: "Primitive germ cell" RELATED []
is_a: CL:0000039 ! germ line cell

[Term]
id: CL:0000680
name: muscle precursor cell
namespace: cell
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0000737
name: striated muscle cell
namespace: cell
def: "Muscle cell which has as its direct parts myofilaments organized into sarcomeres." [GOC:tfm, ISBN:0721662544]
is_a: CL:0000187 ! muscle cell

[Term]
id: CL:0000746
name: cardiac muscle cell
namespace: cell
def: "A myocyte located in the heart. The contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei." [GOC:tfm, ISBN:0323052908]
synonym: "cardiac myocyte" RELATED []
synonym: "cardiocyte" RELATED []
synonym: "cardiomyocyte" RELATED []
synonym: "heart muscle cell" RELATED []
is_a: CL:0000737 ! striated muscle cell

[Term]
id: CL:0000988
name: hematopoietic cell
namespace: cell
def: "A cell of a hematopoietic lineage." [GO_REF:0000031, GOC:add]
synonym: "haematopoietic cell" RELATED []
synonym: "haemopoietic cell" RELATED []
synonym: "hemopoietic cell" RELATED []
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0002242
name: nucleate cell
namespace: cell
def: "A cell containing at least one nucleus." [GOC:tfm]
is_a: CL:0000224 ! cell by nuclear number

[Term]
id: CL:0002319
name: neural cell
namespace: cell
def: "A cell that is part of the nervous system." [GOC:tfm, ISBN:0618947256]
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0002320
name: connective tissue cell
namespace: cell
alt_id: CL:1000406
def: "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone." [GOC:tfm, ISBN:0618947256]
is_a: CL:0002371 ! somatic cell

[Term]
id: CL:0002371
name: somatic cell
namespace: cell
def: "A cell of an organism that does not pass on its genetic material to the organism's offspring (i.e. a non-germ line cell)." [GOC:tfm, ISBN:0721662544]
is_a: CL:0000144 ! cell by function

[Term]
id: CL:0002372
name: myotube
namespace: cell
alt_id: CL:0000369
def: "A myotube is a multinucleated cells that is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:tfm, ISBN:0323052908]
synonym: "myotubule" RELATED []
synonym: "single cell sarcomere" RELATED []
synonym: "skeletal muscle fiber" RELATED []
is_a: CL:0000188 ! skeletal muscle cell
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0000737 ! striated muscle cell

[Term]
id: CL:0002573
name: Schwann cell
namespace: cell
def: "A glial cell that ensheathes axons of neuron in the peripheral nervous system and are necessary for their maintainance and function." [GOC:tfm]
is_a: CL:0000243 ! glial cell (sensu Vertebrata)

[Typedef]
id: derives_from
name: derives_from

[Typedef]
id: descends
name: descends

[Typedef]
id: develops_from
name: develops_from

[Typedef]
id: endStage
name: endStage

[Typedef]
id: hasMapping
name: hasMapping

[Typedef]
id: has_part
name: has_part

[Typedef]
id: isReferenceForMapping
name: isReferenceForMapping

[Typedef]
id: part_of
name: part_of

[Typedef]
id: startStage
name: startStage

[Typedef]
id: subEventOf
name: subEventOf

[Typedef]
id: type
name: type