Planarian Phenotype Ontology (PLANP)
type: Ontology
version IRI: planp.owl
description: Planarian Phenotype Ontology is an ontology of phenotypes observed in the planarian Schmidtea mediterranea.
license: https://creativecommons.org/licenses/by/3.0/

editor preferred term
type: AnnotationProperty

example of usage
type: AnnotationProperty
has curation status: IAO_0000122
database_cross_reference: IAO:0000112
has_obo_namespace: uberon
id: example_of_usage
is metadata tag: true
shorthand: example_of_usage

has curation status
type: AnnotationProperty

definition
type: AnnotationProperty
editor preferred term: definition
has curation status: IAO_0000122
definition: The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.
editor note: 2012-04-05: Barry Smith The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. Can you fix to something like: A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. Alan Ruttenberg Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. On the specifics of the proposed definition: We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.
term editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>

editor note
type: AnnotationProperty
editor preferred term: editor note
has curation status: IAO_0000122
definition: An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology.
term editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obfoundry.org/obo/obi>
database_cross_reference: IAO:0000116
has_obo_namespace: uberon
id: editor_note
is metadata tag: true
shorthand: editor_note

term editor
type: AnnotationProperty
has curation status: IAO_0000122

alternative term
type: AnnotationProperty
has curation status: IAO_0000125

definition source
type: AnnotationProperty
has curation status: IAO_0000122

curator notes
type: AnnotationProperty
editor preferred term: curator note
has curation status: IAO_0000122
definition: An administrative note of use for a curator but of no use for a user
term editor: PERSON:Alan Ruttenberg
database_cross_reference: IAO:0000232
has_obo_namespace: uberon
id: curator_notes
is metadata tag: true
shorthand: curator_notes
label: curator note

imported from
type: AnnotationProperty
editor preferred term: imported from
has curation status: IAO_0000125
definition: For external terms/classes, the ontology from which the term was imported
term editor: PERSON:Alan Ruttenberg
term editor: PERSON:Melanie Courtot
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>

expand expression to
type: AnnotationProperty

expand assertion to
type: AnnotationProperty

OBO foundry unique label
type: AnnotationProperty
has curation status: IAO_0000125

elucidation
type: AnnotationProperty

term replaced by
type: AnnotationProperty

temporal interpretation
type: AnnotationProperty
definition: An assertion that holds between an OWL Object Property and a temporal interpretation that elucidates how OWL Class Axioms that use this property are to be interpreted in a temporal context.

never in taxon
type: AnnotationProperty
example of usage: tooth SubClassOf 'never in taxon' value 'Aves'
definition: x never in taxon T if and only if T is a class, and x does not instantiate the class expression "in taxon some T". Note that this is a shortcut relation, and should be used as a hasValue restriction in OWL.
term editor: Chris Mungall
definition source: http://www.ncbi.nlm.nih.gov/pubmed/17921072
definition source: http://www.ncbi.nlm.nih.gov/pubmed/20973947
expand assertion to: ?X DisjointWith RO_0002162 some ?Y

dubious for taxon
type: AnnotationProperty
definition: S dubious_for_taxon T if it is probably the case that no instances of S can be found in any instance of T.
term editor: https://orcid.org/0000-0002-6601-2165
definition source: http://www.ncbi.nlm.nih.gov/pubmed/22293552
comment: This relation lacks a strong logical interpretation, but can be used in place of never_in_taxon where it is desirable to state that the definition of the class is too strict for the taxon under consideration, but placing a never_in_taxon link would result in a chain of inconsistencies that will take ongoing coordinated effort to resolve. Example: metencephalon in teleost

defined by inverse
type: AnnotationProperty
sub property of: subset_property

logical macro assertion on an annotation property
type: AnnotationProperty

is direct form of
type: AnnotationProperty
definition: relation p is the direct form of relation q iff p is a subPropertyOf q, p does not have the Transitive characteristic, q does have the Transitive characteristic, and for all x, y: x q y -> exists z1, z2, ..., zn such that x p z1 ... z2n y
editor note: The general property hierarchy is: "directly P" SubPropertyOf "P" Transitive(P) Where we have an annotation assertion "directly P" "is direct form of" "P"
logical macro assertion on an annotation property: If we have the annotation P is-direct-form-of Q, and we have inverses P' and Q', then it follows that P' is-direct-form-of Q'
creator: Chris Mungall

is a defining property chain axiom
type: AnnotationProperty
definition: If R <- P o Q is a defining property chain axiom, then it also holds that R -> P o Q. Note that this cannot be expressed directly in OWL

is a defining property chain axiom where second argument is reflexive
type: AnnotationProperty
definition: If R <- P o Q is a defining property chain axiom, then (1) R -> P o Q holds and (2) Q is either reflexive or locally reflexive. A corollary of this is that P SubPropertyOf R.

is opposite of
type: AnnotationProperty
example of usage: 'anterior end of organism' is-opposite-of 'posterior end of organism'
example of usage: 'increase in temperature' is-opposite-of 'decrease in temperature'
definition: x is the opposite of y if there exists some distance metric M, and there exists no z such as M(x,z) <= M(x,y) or M(y,z) <= M(y,x).
database_cross_reference: RO:0002604
has_obo_namespace: quality
id: is_opposite_of
is class level: true
is metadata tag: true
shorthand: is_opposite_of
label: is_opposite_of

is positive form of
type: AnnotationProperty
created by: cjm
creation date: 2018-03-14T00:03:16Z

is negative form of
type: AnnotationProperty
created by: cjm
creation date: 2018-03-14T00:03:24Z

is homeomorphic for
type: AnnotationProperty
example of usage: part-of is homeomorphic for independent continuants.
definition: R is homemorphic for C iff (1) there exists some x,y such that x R y, and x and y instantiate C and (2) for all x, if x is an instance of C, and there exists some y some such that x R y, then it follows that y is an instance of C.
created by: cjm
creation date: 2018-10-21T19:46:34Z
comment: R homeomorphic-for C expands to: C SubClassOf R only C. Additionally, for any class D that is disjoint with C, we can also expand to C DisjointWith R some D, D DisjointWith R some C.

external_definition
type: AnnotationProperty
definition: An alternate textual definition for a class taken unmodified from an external source. This definition may have been used to derive a generalized definition for the new class.
database_cross_reference: UBPROP:0000001
has_obo_namespace: uberon
id: external_definition
is metadata tag: true
shorthand: external_definition
comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO

Axiom
annotated source: external_definition
annotated property: definition
annotated target: An alternate textual definition for a class taken unmodified from an external source. This definition may have been used to derive a generalized definition for the new class.
database_cross_reference: https://orcid.org/0000-0002-6601-2165

homology_notes
type: AnnotationProperty
definition: Notes on the homology status of this class.
database_cross_reference: UBPROP:0000003
has_obo_namespace: uberon
id: homology_notes
is metadata tag: true
shorthand: homology_notes
comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO

Axiom
annotated source: homology_notes
annotated property: definition
annotated target: Notes on the homology status of this class.
database_cross_reference: https://orcid.org/0000-0002-6601-2165

has_relational_adjective
type: AnnotationProperty
curator notes: Used to connect a class to an adjectival form of its label. For example, a class with label 'intestine' may have a relational adjective 'intestinal'.
database_cross_reference: UBPROP:0000007
has_obo_namespace: uberon
id: has_relational_adjective
is metadata tag: true
shorthand: has_relational_adjective

taxon_notes
type: AnnotationProperty
definition: Notes on the how instances of this class vary across species.
database_cross_reference: UBPROP:0000008
has_obo_namespace: uberon
id: taxon_notes
is metadata tag: true
shorthand: taxon_notes

Axiom
annotated source: taxon_notes
annotated property: definition
annotated target: Notes on the how instances of this class vary across species.
database_cross_reference: https://orcid.org/0000-0002-6601-2165

external_ontology_notes
type: AnnotationProperty
definition: Notes on how similar or equivalent classes are represented in other ontologies.
editor note: This annotation property may be replaced with an annotation property from an external ontology such as IAO
database_cross_reference: UBPROP:0000012
has_obo_namespace: uberon
id: external_ontology_notes
is metadata tag: true
shorthand: external_ontology_notes

Axiom
annotated source: external_ontology_notes
annotated property: definition
annotated target: Notes on how similar or equivalent classes are represented in other ontologies.
database_cross_reference: https://orcid.org/0000-0002-6601-2165

synonym typically used in the context of human anatomy
type: AnnotationProperty
database_cross_reference: IAO:0100001
has_scope: has_narrow_synonym

synonym typically used in the context of vertebrate anatomy
type: AnnotationProperty
database_cross_reference: IAO:0100001
has_scope: has_narrow_synonym

gocheck do not annotate
type: AnnotationProperty
comment: Term not to be used for direct annotation
sub property of: subset_property

gocheck do not manually annotate
type: AnnotationProperty
comment: Term not to be used for direct manual annotation
sub property of: subset_property

goslim agr
type: AnnotationProperty
comment: AGR slim
sub property of: subset_property

goslim aspergillus
type: AnnotationProperty
comment: Aspergillus GO slim
sub property of: subset_property

goslim candida
type: AnnotationProperty
comment: Candida GO slim
sub property of: subset_property

goslim chembl
type: AnnotationProperty
comment: ChEMBL protein targets summary
sub property of: subset_property

goslim drosophila
type: AnnotationProperty
comment: Drosophila GO slim
sub property of: subset_property

goslim flybase ribbon
type: AnnotationProperty
comment: FlyBase Drosophila GO ribbon slim
sub property of: subset_property

goslim generic
type: AnnotationProperty
comment: Generic GO slim
sub property of: subset_property

goslim metagenomics
type: AnnotationProperty
comment: Metagenomics GO slim
sub property of: subset_property

goslim mouse
type: AnnotationProperty
comment: Mouse GO slim
sub property of: subset_property

goslim pir
type: AnnotationProperty
comment: PIR GO slim
sub property of: subset_property

goslim plant
type: AnnotationProperty
comment: Plant GO slim
sub property of: subset_property

goslim pombe
type: AnnotationProperty
comment: Fission yeast GO slim
sub property of: subset_property

goslim synapse
type: AnnotationProperty
comment: synapse GO slim
sub property of: subset_property

goslim yeast
type: AnnotationProperty
comment: Yeast GO slim
sub property of: subset_property

Systematic synonym
type: AnnotationProperty
has_scope: has_exact_synonym

abnormal slim
type: AnnotationProperty
comment: Abnormal/normal slim
sub property of: subset_property

absent slim
type: AnnotationProperty
comment: Absent/present slim
sub property of: subset_property

attribute slim
type: AnnotationProperty
comment: Attribute slim
sub property of: subset_property

cell quality
type: AnnotationProperty
comment: cell_quality
sub property of: subset_property

disposition slim
type: AnnotationProperty
comment: Disposition slim
sub property of: subset_property

mpath slim
type: AnnotationProperty
comment: Pathology slim
sub property of: subset_property

relational slim
type: AnnotationProperty
comment: Relational slim: types of quality that require an additional entity in order to exist
sub property of: subset_property

scalar slim
type: AnnotationProperty
comment: Scalar slim
sub property of: subset_property

value slim
type: AnnotationProperty
comment: Value slim
sub property of: subset_property

eco subset
type: AnnotationProperty
sub property of: subset_property

contributor
type: AnnotationProperty
has_obo_namespace: uberon
id: dc-contributor
is metadata tag: true
shorthand: dc-contributor

creator
type: AnnotationProperty
has_obo_namespace: uberon
id: dc-creator
is metadata tag: true
shorthand: dc-creator

derived from resource
type: AnnotationProperty
has_obo_namespace: uberon
id: dc-source
is metadata tag: true
shorthand: dc-source

subset_property
type: AnnotationProperty

synonym_type_property
type: AnnotationProperty
database_cross_reference: IAO:0100001

consider
type: AnnotationProperty

has_alternative_id
type: AnnotationProperty

has_broad_synonym
type: AnnotationProperty

database_cross_reference
type: AnnotationProperty
database_cross_reference: IAO:0100001

has_exact_synonym
type: AnnotationProperty
database_cross_reference: IAO:0100001

has_narrow_synonym
type: AnnotationProperty
database_cross_reference: IAO:0100001

has_obo_format_version
type: AnnotationProperty
database_cross_reference: IAO:0100001

has_obo_namespace
type: AnnotationProperty
database_cross_reference: IAO:0100001

has_related_synonym
type: AnnotationProperty
database_cross_reference: IAO:0100001

has_scope
type: AnnotationProperty
database_cross_reference: IAO:0100001

has_synonym_type
type: AnnotationProperty
database_cross_reference: IAO:0100001

in_subset
type: AnnotationProperty

shorthand
type: AnnotationProperty
database_cross_reference: IAO:0100001

depicted by
type: AnnotationProperty
has_obo_namespace: uberon
id: depicted_by
is metadata tag: true
shorthand: depicted_by

depiction
type: AnnotationProperty
created by: Sofia Robb
creation date: 2017-09-11T16:38:22Z
id: depiction

page
type: AnnotationProperty
has_obo_namespace: uberon
id: foaf-page
is metadata tag: true
shorthand: foaf-page

part of
type: ObjectProperty
equivalent property:
  inverse of: has part
sub property of: overlaps
inverse of: has part
type: TransitiveProperty
editor preferred term: is part of
example of usage: my brain is part of my body (continuant parthood, two material entities)
example of usage: my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)
example of usage: this day is part of this year (occurrent parthood)
definition: a core relation that holds between a part and its whole
editor note: Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other.
editor note: Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime
editor note: Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.) A continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'.
alternative term: part_of
temporal interpretation: RO_0001901
is homeomorphic for: continuant
is homeomorphic for: occurrent
is homeomorphic for: independent continuant
is homeomorphic for: realizable entity
is homeomorphic for: quality
is homeomorphic for: specifically dependent continuant
is homeomorphic for: generically dependent continuant
database_cross_reference: BFO:0000050
has_obo_namespace: external
has_obo_namespace: quality
has_obo_namespace: spatial
has_obo_namespace: uberon
id: part_of
shorthand: part_of
label: part_of

has part
type: ObjectProperty
equivalent property:
  inverse of: part of
sub property of: overlaps
type: TransitiveProperty
editor preferred term: has part
example of usage: my body has part my brain (continuant parthood, two material entities)
example of usage: my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity)
example of usage: this year has part this day (occurrent parthood)
definition: Q1 has_part Q2 if and only if: every instance of Q1 is a quality_of an entity that has_quality some Q2.
definition: a core relation that holds between a whole and its part
editor note: Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part.
editor note: Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime
editor note: Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.) A continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'.
alternative term: has_part
temporal interpretation: RO_0001901
database_cross_reference: BFO:0000051
has_obo_namespace: external
has_obo_namespace: quality
has_obo_namespace: spatial
has_obo_namespace: uberon
id: has_part
shorthand: has_part
comment: We use the has_part relation to relate complex qualities to more primitive ones. A complex quality is a collection of qualities. The complex quality cannot exist without the sub-qualities. For example, the quality 'swollen' necessarily comes with the qualities of 'protruding' and 'increased size'.
label: has_part

Axiom
annotated source: has part
annotated property: definition
annotated target: Q1 has_part Q2 if and only if: every instance of Q1 is a quality_of an entity that has_quality some Q2.
database_cross_reference: PATOC:CJM

preceded_by
type: ObjectProperty
sub property of: ends after
inverse of: precedes
type: TransitiveProperty
domain: occurrent
range: occurrent
property chain axiom: part of
property chain axiom: starts_during
property chain axiom: happens during
editor preferred term: preceded by
definition: X preceded_by Y iff: end(Y) before_or_simultaneous_with start(X)
definition: x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
editor note: An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other.
alternative term: is preceded by
alternative term: preceded_by
derived from resource: http://www.obofoundry.org/ro/#OBO_REL:preceded_by
database_cross_reference: BFO:0000062
has_exact_synonym: is preceded by
has_exact_synonym: takes place after
has_obo_namespace: uberon
id: preceded_by
in_subset: eco subset
shorthand: preceded_by
label: preceded by

Axiom
annotated source: preceded_by
annotated property: has_exact_synonym
annotated target: is preceded by
database_cross_reference: SIO:000249

Axiom
annotated source: preceded_by
annotated property: has_exact_synonym
annotated target: takes place after
database_cross_reference: Allen:precedes

precedes
type: ObjectProperty
sub property of: temporally related to
type: TransitiveProperty
domain: occurrent
range: occurrent
property chain axiom: part of
property chain axiom: happens during
editor preferred term: precedes
definition: x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
database_cross_reference: BFO:0000063
has_obo_namespace: uberon
id: precedes
in_subset: eco subset
shorthand: precedes

occurs in
type: ObjectProperty
inverse of: contains process
domain: occurrent
range: independent continuant
property chain axiom: part of
editor preferred term: occurs in
definition: b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t
alternative term: occurs_in
alternative term: unfolds in
alternative term: unfolds_in
database_cross_reference: BFO:0000066
has_obo_namespace: external
id: occurs_in
shorthand: occurs_in
comment: Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant

contains process
type: ObjectProperty
editor preferred term: site of
definition: [copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t
database_cross_reference: BFO:0000067
has_obo_namespace: uberon
id: contains_process
shorthand: contains_process
comment: Paraphrase of definition: a relation between an independent continuant and a process, in which the process takes place entirely within the independent continuant

anterior to
type: ObjectProperty
inverse of: posterior to
type: TransitiveProperty
definition: x anterior to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that extends through an organism from head end to opposite end of body or tail.
definition: x anterior_to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail: bearer
created by: cjm
creation date: 2009-07-31T02:15:46Z
database_cross_reference: BSPO:0000096
has_exact_synonym: rostral_to
has_obo_namespace: spatial
has_obo_namespace: uberon
id: anterior_to
shorthand: anterior_to
label: anterior_to

Axiom
annotated source: anterior to
annotated property: definition
annotated target: x anterior to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that extends through an organism from head end to opposite end of body or tail.
database_cross_reference: BSPO:cjm

Axiom
annotated source: anterior to
annotated property: definition
annotated target: x anterior_to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail: bearer
database_cross_reference: http://orcid.org/0000-0002-6601-2165

dorsal to
type: ObjectProperty
inverse of: ventral to
type: TransitiveProperty
definition: x dorsal to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that extends through an organism from back (e.g. spinal column) to front (e.g. belly).
definition: x dorsal_to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly).
database_cross_reference: BSPO:0000098
has_obo_namespace: spatial
has_obo_namespace: uberon
id: dorsal_to
shorthand: dorsal_to
label: dorsal_to

Axiom
annotated source: dorsal to
annotated property: definition
annotated target: x dorsal to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that extends through an organism from back (e.g. spinal column) to front (e.g. belly).
database_cross_reference: BSPO:cjm

Axiom
annotated source: dorsal to
annotated property: definition
annotated target: x dorsal_to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly).
database_cross_reference: http://orcid.org/0000-0002-6601-2165

posterior to
type: ObjectProperty
type: TransitiveProperty
definition: x posterior to y iff x is further along the antero-posterior axis than y, towards the body/tail. An antero-posterior axis is an axis that extends through an organism from head end to opposite end of body or tail.
definition: x posterior_to y iff x is further along the antero-posterior axis than y, towards the body/tail. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail.
database_cross_reference: BSPO:0000099
has_narrow_synonym: caudal to
has_narrow_synonym: caudal_to
has_obo_namespace: spatial
has_obo_namespace: uberon
id: posterior_to
shorthand: posterior_to
label: posterior_to

Axiom
annotated source: posterior to
annotated property: definition
annotated target: x posterior to y iff x is further along the antero-posterior axis than y, towards the body/tail. An antero-posterior axis is an axis that extends through an organism from head end to opposite end of body or tail.
database_cross_reference: BSPO:cjm

Axiom
annotated source: posterior to
annotated property: definition
annotated target: x posterior_to y iff x is further along the antero-posterior axis than y, towards the body/tail. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail.
database_cross_reference: http://orcid.org/0000-0002-6601-2165

Axiom
annotated source: posterior to
annotated property: has_narrow_synonym
annotated target: caudal to
has_synonym_type: synonym typically used in the context of vertebrate anatomy

ventral to
type: ObjectProperty
type: TransitiveProperty
definition: x ventral to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that extends through an organism from back (e.g. spinal column) to front (e.g. belly).
definition: x ventral_to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly).
database_cross_reference: BSPO:0000102
has_obo_namespace: spatial
has_obo_namespace: uberon
id: ventral_to
shorthand: ventral_to
label: ventral_to

Axiom
annotated source: ventral to
annotated property: definition
annotated target: x ventral to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that extends through an organism from back (e.g. spinal column) to front (e.g. belly).
database_cross_reference: BSPO:cjm

Axiom
annotated source: ventral to
annotated property: definition
annotated target: x ventral_to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly).
database_cross_reference: http://orcid.org/0000-0002-6601-2165

approximately perpendicular to
type: ObjectProperty
domain: anatomical axis
range: anatomical axis
definition: Crosses at an angle that is 90 degrees, or close to 90 degrees. In any non-linear organism, the main axes are rarely perpendicular when taken through the organism as a whole.
database_cross_reference: BSPO:0000104
has_obo_namespace: spatial
id: approximately_perpendicular_to
shorthand: approximately_perpendicular_to

Axiom
annotated source: approximately perpendicular to
annotated property: definition
annotated target: Crosses at an angle that is 90 degrees, or close to 90 degrees. In any non-linear organism, the main axes are rarely perpendicular when taken through the organism as a whole.
database_cross_reference: BSPO:cjm

ipsilateral to
type: ObjectProperty
sub property of: in lateral side of
type: SymmetricProperty
definition: On the same side as. For example, the left arm is ipsilateral to the left leg.
database_cross_reference: BSPO:0000105
has_obo_namespace: spatial
id: ipsilateral_to
shorthand: ipsilateral_to

Axiom
annotated source: ipsilateral to
annotated property: definition
annotated target: On the same side as. For example, the left arm is ipsilateral to the left leg.
database_cross_reference: BSPO:cjm

deep to
type: ObjectProperty
inverse of: superficial to
type: TransitiveProperty
definition: Further away from the surface of the organism. Thus, the muscular layer is deep to the skin, but superficial to the intestines.
database_cross_reference: BSPO:0000107
has_obo_namespace: spatial
has_obo_namespace: uberon
id: deep_to
shorthand: deep_to
label: deep_to

Axiom
annotated source: deep to
annotated property: definition
annotated target: Further away from the surface of the organism. Thus, the muscular layer is deep to the skin, but superficial to the intestines.
database_cross_reference: http://orcid.org/0000-0002-6601-2165

Axiom
annotated source: deep to
annotated property: definition
annotated target: Further away from the surface of the organism. Thus, the muscular layer is deep to the skin, but superficial to the intestines.
database_cross_reference: BSPO:cjm

superficial to
type: ObjectProperty
type: TransitiveProperty
definition: Near the outer surface of the organism. Thus, skin is superficial to the muscle layer.
database_cross_reference: BSPO:0000108
has_obo_namespace: spatial
has_obo_namespace: uberon
id: superficial_to
shorthand: superficial_to
label: superficial_to

Axiom
annotated source: superficial to
annotated property: definition
annotated target: Near the outer surface of the organism. Thus, skin is superficial to the muscle layer.
database_cross_reference: http://orcid.org/0000-0002-6601-2165

Axiom
annotated source: superficial to
annotated property: definition
annotated target: Near the outer surface of the organism. Thus, skin is superficial to the muscle layer.
database_cross_reference: BSPO:cjm

opposite to
type: ObjectProperty
sub property of: ipsilateral to
definition: Direcly opposite to. i.e. on the opposite side through the axis.
database_cross_reference: BSPO:0000113
has_obo_namespace: spatial
id: opposite_to
shorthand: opposite_to

Axiom
annotated source: opposite to
annotated property: definition
annotated target: Direcly opposite to. i.e. on the opposite side through the axis.
database_cross_reference: BSPO:cjm

in lateral side of
type: ObjectProperty
sub property of: part of
definition: X in lateral side of Y <=> if X is in left side of Y or X is in right side of Y. X is often, but not always a paired structure
definition: X in_lateral_side_of Y <=> if X is in_left_side_of Y or X is in_right_side_of Y. X is often, but not always a paired structure
database_cross_reference: BSPO:0000126
has_obo_namespace: spatial
has_obo_namespace: uberon
id: in_lateral_side_of
shorthand: in_lateral_side_of
label: in_lateral_side_of

Axiom
annotated source: in lateral side of
annotated property: definition
annotated target: X in lateral side of Y <=> if X is in left side of Y or X is in right side of Y. X is often, but not always a paired structure
database_cross_reference: UBERON:cjm

Axiom
annotated source: in lateral side of
annotated property: definition
annotated target: X in_lateral_side_of Y <=> if X is in_left_side_of Y or X is in_right_side_of Y. X is often, but not always a paired structure
database_cross_reference: https://orcid.org/0000-0002-6601-2165

immediately deep to
type: ObjectProperty
sub property of: deep to
sub property of: adjacent to
inverse of: immediately superficial to
definition: This relation holds when both the deep_to and ajdacent_to relationship similarly hold.
definition: x immediately deep to y iff x deep_to y and x is contiguous with y.
database_cross_reference: BSPO:0001107
has_obo_namespace: spatial
has_obo_namespace: uberon
id: immediately_deep_to
shorthand: immediately_deep_to
label: immediately_deep_to

Axiom
annotated source: immediately deep to
annotated property: definition
annotated target: This relation holds when both the deep_to and ajdacent_to relationship similarly hold.
database_cross_reference: http://orcid.org/0000-0002-6601-2165

Axiom
annotated source: immediately deep to
annotated property: definition
annotated target: x immediately deep to y iff x deep_to y and x is contiguous with y.
database_cross_reference: BSPO:curators

finishes axis
type: ObjectProperty
domain: anatomical side
range: anatomical axis
database_cross_reference: BSPO:0015001
has_obo_namespace: spatial
id: finishes_axis
shorthand: finishes_axis
comment: A directional axis can be divided by a plane. Following Allen Interval Algebra terminology we say that the side on which the axis initiates starts the axis, with the other side finishing the axis. If s finishes axis x, and x has end point p, then x overlaps p

orthogonal to
type: ObjectProperty
domain: anatomical axis
range: anatomical plane
definition: crossing at right angles
database_cross_reference: BSPO:0015005
has_obo_namespace: spatial
id: orthogonal_to
shorthand: orthogonal_to

Axiom
annotated source: orthogonal to
annotated property: definition
annotated target: crossing at right angles
database_cross_reference: BSPO:cjm

passes through
type: ObjectProperty
domain: anatomical axis
definition: Intersects at two points.
database_cross_reference: BSPO:0015006
has_obo_namespace: spatial
id: passes_through
shorthand: passes_through

Axiom
annotated source: passes through
annotated property: definition
annotated target: Intersects at two points.
database_cross_reference: BSPO:cjm

starts axis
type: ObjectProperty
domain: anatomical side
range: anatomical axis
database_cross_reference: BSPO:0015007
has_obo_namespace: spatial
id: starts_axis
shorthand: starts_axis
comment: A directional axis can be divided by a plane. Following Allen Interval Algebra terminology we say that the side on which the axis initiates starts the axis, with the other side finishing the axis. . If s starts axis x, and x has start point p, then x overlaps p

surface of
type: ObjectProperty
domain: anatomical surface
database_cross_reference: BSPO:0015008
has_obo_namespace: spatial
id: surface_of
shorthand: surface_of
comment: placeholder. used for relation between anatomical surface and an anatomical side.

immediately superficial to
type: ObjectProperty
sub property of: superficial to
sub property of: adjacent to
definition: x immediately superficial to y iff x superficial to y and x is contiguous with y.
database_cross_reference: BSPO:0015014
has_obo_namespace: spatial
has_obo_namespace: uberon
id: immediately_superficial_to
shorthand: immediately_superficial_to
label: immediately_superficial_to

Axiom
annotated source: immediately superficial to
annotated property: definition
annotated target: x immediately superficial to y iff x superficial to y and x is contiguous with y.
database_cross_reference: BSPO:curators

is about
type: ObjectProperty
example of usage: This document is about information artifacts and their representations
has curation status: IAO_0000125
definition: is_about is a (currently) primitive relation that relates an information artifact to an entity.
editor note: 7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of "mentions" relation. Weaken the is_about relationship to be primitive. We will try to build it back up by elaborating the various subproperties that are more precisely defined. Some currently missing phenomena that should be considered "about" are predications - "The only person who knows the answer is sitting beside me" , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic.
term editor: person:Alan Ruttenberg
definition source: Smith, Ceusters, Ruttenberg, 2000 years of philosophy

specific_to
type: ObjectProperty
type: TransitiveProperty
definition: Restricted to domain
shorthand: specific_to

inheres in
type: ObjectProperty
sub property of: inheres in part of
inverse of: bearer of
editor preferred term: inheres in
example of usage: this fragility inheres in this vase
example of usage: this red color inheres in this apple
definition: a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence
editor note: A dependent inheres in its bearer at all times for which the dependent exists.
alternative term: inheres_in
temporal interpretation: RO_0001901

bearer of
type: ObjectProperty
range: specifically dependent continuant
editor preferred term: bearer of
example of usage: this apple is bearer of this red color
example of usage: this vase is bearer of this fragility
definition: a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence
editor note: A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist.
alternative term: bearer_of
alternative term: is bearer of
temporal interpretation: RO_0001901
database_cross_reference: RO:0000053
has_obo_namespace: uberon
id: bearer_of
shorthand: bearer_of

participates in
type: ObjectProperty
inverse of: has participant
domain: continuant
range: occurrent
editor preferred term: participates in
example of usage: this blood clot participates in this blood coagulation
example of usage: this input material (or this output material) participates in this process
example of usage: this investigator participates in this investigation
definition: a relation between a continuant and a process, in which the continuant is somehow involved in the process
alternative term: participates_in

has participant
type: ObjectProperty
domain: occurrent
range: continuant
property chain axiom: has part
editor preferred term: has participant
example of usage: this blood coagulation has participant this blood clot
example of usage: this investigation has participant this investigator
example of usage: this process has participant this input material (or this output material)
definition: a relation between a process and a continuant, in which the continuant is somehow involved in the process
editor note: Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time.
alternative term: has_participant
derived from resource: http://www.obofoundry.org/ro/#OBO_REL:has_participant

quality of
type: ObjectProperty
sub property of: inheres in
inverse of: has quality
example of usage: this red color is a quality of this apple
definition: a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence
editor note: A quality inheres in its bearer at all times for which the quality exists.
alternative term: is quality of
alternative term: quality_of

has quality
type: ObjectProperty
sub property of: bearer of
range: quality
example of usage: this apple has quality this red color
definition: a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence
editor note: A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist.
alternative term: has_quality

derives from
type: ObjectProperty
inverse of: derives into
example of usage: this cell derives from this parent cell (cell division)
example of usage: this nucleus derives from this parent nucleus (nuclear division)
has curation status: IAO_0000125
definition: a relation between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity
editor note: This is a very general relation. More specific relations are preferred when applicable, such as 'directly develops from'.
alternative term: derives_from
curator notes: This relation is taken from the RO2005 version of RO. It may be obsoleted and replaced by relations with different definitions. See also the 'develops from' family of relations.
in_subset: eco subset

derives into
type: ObjectProperty
example of usage: this parent cell derives into this cell (cell division)
example of usage: this parent nucleus derives into this nucleus (nuclear division)
has curation status: IAO_0000125
definition: a relation between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity
editor note: This is a very general relation. More specific relations are preferred when applicable, such as 'directly develops into'. To avoid making statements about a future that may not come to pass, it is often better to use the backward-looking 'derives from' rather than the forward-looking 'derives into'.
alternative term: derives_into
in_subset: eco subset

location of
type: ObjectProperty
inverse of: located in
type: TransitiveProperty
editor preferred term: is location of
example of usage: my head is the location of my brain
example of usage: this cage is the location of this rat
definition: a relation between two independent continuants, the location and the target, in which the target is entirely within the location
editor note: Most location relations will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime
alternative term: location_of
temporal interpretation: RO_0001901

contained in
type: ObjectProperty
inverse of: contains
domain: material entity
range: independent continuant
property chain axiom: located in
property chain axiom: part of
editor preferred term: contained in
editor note: Containment is location not involving parthood, and arises only where some immaterial continuant is involved.
editor note: Containment obtains in each case between material and immaterial continuants, for instance: lung contained_in thoracic cavity; bladder contained_in pelvic cavity. Hence containment is not a transitive relation. If c part_of c1 at t then we have also, by our definition and by the axioms of mereology applied to spatial regions, c located_in c1 at t. Thus, many examples of instance-level location relations for continuants are in fact cases of instance-level parthood. For material continuants location and parthood coincide. Containment is location not involving parthood, and arises only where some immaterial continuant is involved. To understand this relation, we first define overlap for continuants as follows: c1 overlap c2 at t =def for some c, c part_of c1 at t and c part_of c2 at t. The containment relation on the instance level can then be defined (see definition):
editor note: Intended meaning: domain: material entity range: spatial region or site (immaterial continuant)
alternative term: contained_in
temporal interpretation: RO_0001901
in_subset: eco subset

contains
type: ObjectProperty
editor preferred term: contains
temporal interpretation: RO_0001901
database_cross_reference: RO:0001019
has_obo_namespace: uberon
id: contains
in_subset: eco subset
shorthand: contains

located in
type: ObjectProperty
type: TransitiveProperty
domain: independent continuant
domain: Class
  intersection of: independent continuant
  intersection of: Class
    complement of: spatial region
range: independent continuant
range: Class
  intersection of: independent continuant
  intersection of: Class
    complement of: spatial region
property chain axiom: part of
editor preferred term: located in
example of usage: my brain is located in my head
example of usage: this rat is located in this cage
definition: a relation between two independent continuants, the target and the location, in which the target is entirely within the location
editor note: Location as a relation between instances: The primitive instance-level relation c located_in r at t reflects the fact that each continuant is at any given time associated with exactly one spatial region, namely its exact location. Following we can use this relation to define a further instance-level location relation - not between a continuant and the region which it exactly occupies, but rather between one continuant and another. c is located in c1, in this sense, whenever the spatial region occupied by c is part_of the spatial region occupied by c1. Note that this relation comprehends both the relation of exact location between one continuant and another which obtains when r and r1 are identical (for example, when a portion of fluid exactly fills a cavity), as well as those sorts of inexact location relations which obtain, for example, between brain and head or between ovum and uterus
editor note: Most location relations will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime
alternative term: located_in
temporal interpretation: RO_0001901
derived from resource: http://www.obofoundry.org/ro/#OBO_REL:located_in

Axiom
annotated source: located in
annotated property: domain
annotated target: independent continuant
editor note: This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation.

Axiom
annotated source: located in
annotated property: range
annotated target: independent continuant
editor note: This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation.

has regulatory component activity
type: ObjectProperty
sub property of: has component activity
sub property of: regulated by
definition: A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B.
created by: dos
creation date: 2017-05-24T09:30:46Z

has negative regulatory component activity
type: ObjectProperty
sub property of: has regulatory component activity
sub property of: negatively regulated by
definition: A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B.
created by: dos
creation date: 2017-05-24T09:31:01Z
comment: By convention GO molecular functions are classified by their effector function. Internal regulatory functions are treated as components. For example, NMDA glutmate receptor activity is a cation channel activity with positive regulatory component 'glutamate binding' and negative regulatory components including 'zinc binding' and 'magnesium binding'.

has positive regulatory component activity
type: ObjectProperty
sub property of: has regulatory component activity
sub property of: positively regulated by
definition: A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B.
created by: dos
creation date: 2017-05-24T09:31:17Z
comment: By convention GO molecular functions are classified by their effector function and internal regulatory functions are treated as components. So, for example calmodulin has a protein binding activity that has positive regulatory component activity calcium binding activity. Receptor tyrosine kinase activity is a tyrosine kinase activity that has positive regulatory component 'ligand binding'.

has component activity
type: ObjectProperty
sub property of: has component process
created by: dos
creation date: 2017-05-24T09:44:33Z
comment: A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B.

has component process
type: ObjectProperty
sub property of: has component
domain: process
range: process
definition: w 'has process component' p if p and w are processes, w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type.
created by: dos
creation date: 2017-05-24T09:49:21Z

has ligand
type: ObjectProperty
sub property of: has input
domain: GO_0004872
definition: A relationship that holds between between a receptor and an chemical entity, typically a small molecule or peptide, that carries information between cells or compartments of a cell and which binds the receptor and regulates its effector function.
created by: dos
creation date: 2017-07-19T17:30:36Z

directly regulated by
type: ObjectProperty
sub property of: regulated by
inverse of: directly regulates
created by: dos
creation date: 2017-09-17T13:52:24Z
comment: Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2.

Axiom
annotated source: directly regulated by
annotated property: comment
annotated target: Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2.
database_cross_reference: GOC:dos

directly negatively regulated by
type: ObjectProperty
sub property of: directly regulated by
inverse of: directly negatively regulates
definition: Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1.
created by: dos
creation date: 2017-09-17T13:52:38Z

Axiom
annotated source: directly negatively regulated by
annotated property: definition
annotated target: Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1.
database_cross_reference: GOC:dos

directly positively regulated by
type: ObjectProperty
sub property of: directly regulated by
inverse of: directly positively regulates
definition: Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1.
created by: dos
creation date: 2017-09-17T13:52:47Z

Axiom
annotated source: directly positively regulated by
annotated property: definition
annotated target: Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1.
database_cross_reference: GOC:dos

has effector activity
type: ObjectProperty
sub property of: has component activity
sub property of: regulates
type: FunctionalProperty
definition: A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity.
created by: dos
creation date: 2017-09-22T14:14:36Z
comment: This relation is designed for constructing compound molecular functions, typically in combination with one or more regulatory component activity relations.

Axiom
annotated source: has effector activity
annotated property: definition
annotated target: A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity.
database_cross_reference: GOC:dos

before or simultaneous with
type: ObjectProperty
sub property of: temporally related to
term editor: David Osumi-Sutherland
alternative term: <=
in_subset: eco subset
comment: Primitive instance level timing relation between events

simultaneous with
type: ObjectProperty
sub property of: before or simultaneous with
type: TransitiveProperty
term editor: David Osumi-Sutherland
in_subset: eco subset
comment: t1 simultaneous_with t2 iff:= t1 before_or_simultaneous_with t2 and not (t1 before t2)

during which ends
type: ObjectProperty
sub property of: temporally related to
inverse of: ends_during
term editor: David Osumi-Sutherland
in_subset: eco subset
comment: Previously had ID http://purl.obolibrary.org/obo/RO_0002122 in test files in sandpit - but this seems to have been dropped from ro-edit.owl at some point. No re-use under this ID AFAIK, but leaving note here in case we run in to clashes down the line. Official ID now chosen from DOS ID range.

encompasses
type: ObjectProperty
sub property of: during which starts
inverse of: happens during
type: TransitiveProperty
term editor: David Osumi-Sutherland
alternative term: di
comment: Previously had ID http://purl.obolibrary.org/obo/RO_0002124 in test files in sandpit - but this seems to have been dropped from ro-edit.owl at some point. No re-use under this ID AFAIK, but leaving note here in case we run in to clashes down the line. Official ID now chosen from DOS ID range.

ends after
type: ObjectProperty
sub property of: temporally related to
type: TransitiveProperty
property chain axiom: ends_during
property chain axiom: preceded_by
term editor: David Osumi-Sutherland
in_subset: eco subset
comment: X ends_after Y iff: end(Y) before_or_simultaneous_with end(X)

immediately_preceded_by
type: ObjectProperty
sub property of: preceded_by
inverse of: immediately precedes
property chain axiom: starts with
property chain axiom: ends with
definition: X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)
term editor: David Osumi-Sutherland
alternative term: starts_at_end_of
external_definition: A non-transitive temporal relation in which one process immediately precedes another process, such that there is no interval of time between the two processes[SIO:000251].
database_cross_reference: RO:0002087
has_exact_synonym: directly preceded by
has_exact_synonym: is directly preceded by
has_exact_synonym: is immediately preceded by
has_exact_synonym: starts_at_end_of
has_obo_namespace: uberon
id: immediately_preceded_by
shorthand: immediately_preceded_by
comment: X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)
label: immediately preceded by

Axiom
annotated source: immediately_preceded_by
annotated property: external_definition
annotated target: A non-transitive temporal relation in which one process immediately precedes another process, such that there is no interval of time between the two processes[SIO:000251].
source: SIO:000251

Axiom
annotated source: immediately_preceded_by
annotated property: has_exact_synonym
annotated target: is immediately preceded by
database_cross_reference: SIO:000251

during which starts
type: ObjectProperty
sub property of: temporally related to
inverse of: starts_during
term editor: David Osumi-Sutherland
in_subset: eco subset
comment: Previously had ID http://purl.obolibrary.org/obo/RO_0002123 in test files in sandpit - but this seems to have been dropped from ro-edit.owl at some point. No re-use under this ID AFAIK, but leaving note here in case we run in to clashes down the line. Official ID now chosen from DOS ID range.

immediately precedes
type: ObjectProperty
sub property of: precedes
property chain axiom: ends with
property chain axiom: starts with
term editor: David Osumi-Sutherland
alternative term: ends_at_start_of
alternative term: meets
is direct form of: precedes
in_subset: eco subset
comment: X immediately_precedes_Y iff: end(X) simultaneous_with start(Y)

starts_during
type: ObjectProperty
sub property of: temporally related to
domain: occurrent
range: occurrent
term editor: David Osumi-Sutherland
alternative term: io
database_cross_reference: RO:0002091
has_obo_namespace: external
id: starts_during
in_subset: eco subset
shorthand: starts_during
comment: X starts_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (start(X) before_or_simultaneous_with end(Y))
label: starts during

happens during
type: ObjectProperty
sub property of: ends_during
type: TransitiveProperty
term editor: David Osumi-Sutherland
alternative term: d
alternative term: during
database_cross_reference: RO:0002092
has_obo_namespace: external
id: happens_during
in_subset: eco subset
shorthand: happens_during
comment: X happens_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (end(X) before_or_simultaneous_with end(Y))

ends_during
type: ObjectProperty
sub property of: temporally related to
term editor: David Osumi-Sutherland
alternative term: o
alternative term: overlaps
database_cross_reference: RO:0002093
has_obo_namespace: external
id: ends_during
in_subset: eco subset
shorthand: ends_during
comment: X ends_during Y iff: ((start(Y) before_or_simultaneous_with end(X)) AND end(X) before_or_simultaneous_with end(Y).
label: ends during

has plasma membrane part
type: ObjectProperty
sub property of: has part
domain: material anatomical entity
range: material anatomical entity
example of usage: Every B cell[CL_0000236] has plasma membrane part some immunoglobulin complex[GO_0019814]
has curation status: IAO_0000125
definition: Holds between a cell c and a protein complex or protein p if and only if that cell has as part a plasma_membrane[GO:0005886], and that plasma membrane has p as part.
term editor: Alexander Diehl
term editor: Chris Mungall
term editor: Lindsay Cowell
definition source: http://www.ncbi.nlm.nih.gov/pubmed/19243617
expand expression to: <http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0005886> and <http://purl.obolibrary.org/obo/BFO_0000051> some ?Y)
temporal interpretation: RO_0001901

overlaps
type: ObjectProperty
sub property of: mereotopologically related to
property chain axiom: part of
property chain axiom: has part
has curation status: IAO_0000125
definition: A overlaps B if they share some part in common.
definition: x overlaps y if and only if there exists some z such that x has part z and z part of y
definition: x overlaps y iff they have some part in common.
expand expression to: BFO_0000051 some (BFO_0000050 some ?Y)
expand expression to: http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y)
temporal interpretation: RO_0001901
database_cross_reference: RO:0002131
has_obo_namespace: spatial
has_obo_namespace: uberon
id: overlaps
in_subset: eco subset
shorthand: overlaps
comment: "(forall (x y) (iff (overlaps x y) (exists (z) (and (part of z x) (part of z y)))))" CLIF []

Axiom
annotated source: overlaps
annotated property: propertyChainAxiom
annotated target: has part
annotated target: part of
RO_0002582: true

Axiom
annotated source: overlaps
annotated property: definition
annotated target: x overlaps y iff they have some part in common.
database_cross_reference: BSPO:cjm

derived by descent from
type: ObjectProperty
sub property of: evolutionarily related to
inverse of: has derived by descendant
type: TransitiveProperty
has curation status: IAO_0000125
definition: d derived_by_descent_from a if d is specified by some genetic program that is sequence-inherited-from a genetic program that specifies a.
alternative term: ancestral_stucture_of
alternative term: evolutionarily_descended_from

has derived by descendant
type: ObjectProperty
sub property of: evolutionarily related to
type: TransitiveProperty
has curation status: IAO_0000125
definition: inverse of derived by descent from
in_subset: defined by inverse

shares ancestor with
type: ObjectProperty
sub property of: evolutionarily related to
type: SymmetricProperty
type: TransitiveProperty
property chain axiom: derived by descent from
property chain axiom: has derived by descendant
has curation status: IAO_0000125
definition: two individual entities d1 and d2 stand in a shares_ancestor_with relation if and only if there exists some a such that d1 derived_by_descent_from a and d2 derived_by_descent_from a.
curator notes: Consider obsoleting and merging with child relation, 'in homology relationship with'
comment: VBO calls this homologous_to

serially homologous to
type: ObjectProperty
sub property of: evolutionarily related to
type: SymmetricProperty
type: TransitiveProperty
has curation status: IAO_0000125

only in taxon
type: ObjectProperty
sub property of: in taxon
example of usage: lactation SubClassOf 'only in taxon' some 'Mammalia'
has curation status: IAO_0000125
definition: x only in taxon y if and only if x is in taxon y, and there is no other organism z such that y!=z a and x is in taxon z.
editor note: The original intent was to treat this as a macro that expands to 'in taxon' only ?Y - however, this is not necessary if we instead have supplemental axioms that state that each pair of sibling tax have a disjointness axiom using the 'in taxon' property - e.g. 'in taxon' some Eukaryota DisjointWith 'in taxon' some Eubacteria
term editor: Chris Mungall
definition source: http://www.ncbi.nlm.nih.gov/pubmed/17921072
definition source: http://www.ncbi.nlm.nih.gov/pubmed/20973947

in taxon
type: ObjectProperty
sub property of: evolutionarily related to
range: organism or virus or viroid
property chain axiom: part of
property chain axiom: has part
property chain axiom: develops_from
property chain axiom: capable of
property chain axiom: develops from part of
property chain axiom: has developmental contribution from
has curation status: IAO_0000125
definition: x is in taxon y if an only if y is an organism, and the relationship between x and y is one of: part of (reflexive), developmentally preceded by, derives from, secreted by, expressed.
term editor: Chris Mungall
term editor: Jennifer Deegan
definition source: http://www.ncbi.nlm.nih.gov/pubmed/17921072
definition source: http://www.ncbi.nlm.nih.gov/pubmed/20973947
in_subset: eco subset
comment: Connects a biological entity to its taxon of origin.

spatially disjoint from
type: ObjectProperty
sub property of: mereotopologically related to
has curation status: IAO_0000125
definition: A is spatially_disjoint_from B if and only if they have no parts in common
editor note: There are two ways to encode this as a shortcut relation. The other possibility to use an annotation assertion between two classes, and expand this to a disjointness axiom.
term editor: Chris Mungall
definition source: http://www.ncbi.nlm.nih.gov/pubmed/22293552
curator notes: Note that it would be possible to use the relation to label the relationship between a near infinite number of structures - between the rings of saturn and my left earlobe. The intent is that this is used for parsiomoniously for disambiguation purposes - for example, between siblings in a jointly exhaustive pairwise disjointness hierarchy
expand expression to: BFO_0000051 exactly 0 (BFO_0000050 some ?Y)
temporal interpretation: RO_0001901
in_subset: eco subset

connected to
type: ObjectProperty
sub property of: mereotopologically related to
domain: Restriction
  on property: part of
  some values from: RO_0002577
range: Restriction
  on property: part of
  some values from: RO_0002577
example of usage: a 'toe distal phalanx bone' that is connected to a 'toe medial phalanx bone' (an interphalangeal joint *connects* these two bones).
definition: a is connected to b if and only if a and b are discrete structure, and there exists some connecting structure c, such that c connects a and b
definition source: http://www.ncbi.nlm.nih.gov/pubmed/22293552

attached to part of
type: ObjectProperty
sub property of: mereotopologically related to
sub property of: biomechanically related to
domain: anatomical structure
range: anatomical structure
property chain axiom: attached to
property chain axiom: part of
definition: a is attached to part of b if a is attached to b, or a is attached to some p, where p is part of b.
OBO foundry unique label: attached to part of (anatomical structure to anatomical structure)

Axiom
annotated source: attached to part of
annotated property: propertyChainAxiom
annotated target: attached to
annotated target: part of
RO_0002582: true

has component
type: ObjectProperty
sub property of: has part
has curation status: IAO_0000125
definition: w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type.
editor note: The definition of 'has component' is still under discussion. The challenge is in providing a definition that does not imply transitivity.
curator notes: For use in recording has_part with a cardinality constraint, because OWL does not permit cardinality constraints to be used in combination with transitive object properties. In situations where you would want to say something like 'has part exactly 5 digit, you would instead use has_component exactly 5 digit.
temporal interpretation: RO_0001901
database_cross_reference: RO:0002180
has_obo_namespace: uberon
id: has_component
in_subset: eco subset
shorthand: has_component

has phenotype
type: ObjectProperty
sub property of: topObjectProperty
inverse of: phenotype of
domain: Class
  union of: generically dependent continuant
  union of: material anatomical entity
  union of: OGMS_0000031
range: UPHENO_0001001
has curation status: IAO_0000125
definition: A relationship that holds between a biological entity and a phenotype. Here a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature). The subject of this relationship can be an organism (where the organism has the phenotype, i.e. the qualities inhere in parts of this organism), a genomic entity such as a gene or genotype (if modifications of the gene or the genotype causes the phenotype), or a condition such as a disease (such that if the condition inheres in an organism, then the organism has the phenotype).
term editor: Chris Mungall
in_subset: eco subset

phenotype of
type: ObjectProperty
sub property of: topObjectProperty
type: FunctionalProperty
has curation status: IAO_0000125
definition: inverse of has phenotype
term editor: Chris Mungall
in_subset: defined by inverse
in_subset: eco subset

develops_from
type: ObjectProperty
sub property of: has developmental contribution from
sub property of: developmentally preceded by
inverse of: develops_into
type: TransitiveProperty
domain: independent continuant
range: independent continuant
has curation status: IAO_0000125
definition: x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y
term editor: Chris Mungall
term editor: David Osumi-Sutherland
term editor: Melissa Haendel
term editor: Terry Meehan
database_cross_reference: RO:0002202
has_obo_namespace: uberon
id: develops_from
shorthand: develops_from
comment: This is the transitive form of the develops from relation
label: develops from

develops_into
type: ObjectProperty
sub property of: developmentally succeeded by
sub property of: has potential to develop into
sub property of: has potential to directly develop into
type: TransitiveProperty
has curation status: IAO_0000125
definition: inverse of develops from
term editor: Chris Mungall
term editor: David Osumi-Sutherland
term editor: Terry Meehan
database_cross_reference: RO:0002203
has_obo_namespace: uberon
id: develops_into
in_subset: defined by inverse
shorthand: develops_into
label: develops into

directly develops from
type: ObjectProperty
sub property of: develops_from
inverse of: directly develops into
domain: Class
  union of: multicellular anatomical structure
  union of: cell
range: Class
  union of: multicellular anatomical structure
  union of: cell
has curation status: IAO_0000125
definition: Candidate definition: x directly_develops from y if and only if there exists some developmental process (GO:0032502) p such that x and y both participate in p, and x is the output of p and y is the input of p, and a substantial portion of the matter of x comes from y, and the start of x is coincident with or after the end of y.
term editor: Chris Mungall
term editor: David Osumi-Sutherland
term editor: has developmental precursor
definition source: FBbt
is direct form of: develops_from
comment: TODO - add child relations from DOS

directly develops into
type: ObjectProperty
sub property of: develops_into
has curation status: IAO_0000125
definition: inverse of directly develops from
alternative term: developmental precursor of
in_subset: defined by inverse

regulates
type: ObjectProperty
sub property of: causally upstream of
inverse of: regulated by
type: TransitiveProperty
domain: process
range: process
property chain axiom: ends with
property chain axiom: directly regulates
has curation status: IAO_0000125
definition: process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2.
editor note: We use 'regulates' here to specifically imply control. However, many colloquial usages of the term correctly correspond to the weaker relation of 'causally upstream of or within' (aka influences). Consider relabeling to make things more explicit
term editor: Chris Mungall
term editor: David Hill
term editor: Tanya Berardini
definition source: causal-relations
definition source: GO
curator notes: Regulation precludes parthood; the regulatory process may not be within the regulated process.
OBO foundry unique label: regulates (processual)
elucidation: false
database_cross_reference: RO:0002211
has_obo_namespace: external
id: regulates
shorthand: regulates

negatively regulates
type: ObjectProperty
sub property of: regulates
sub property of: causally upstream of, negative effect
inverse of: negatively regulated by
property chain axiom: ends with
definition: Process(P1) negatively regulates process(P2) iff: P1 terminates P2, or P1 descreases the the frequency of initiation of P2 or the magnitude or rate of output of P2.
term editor: Chris Mungall
definition source: causal-relations
OBO foundry unique label: negatively regulates (process to process)
is negative form of: regulates
database_cross_reference: RO:0002212
has_obo_namespace: external
id: negatively_regulates
shorthand: negatively_regulates

positively regulates
type: ObjectProperty
sub property of: regulates
sub property of: causally upstream of, positive effect
inverse of: positively regulated by
type: TransitiveProperty
property chain axiom: negatively regulates
property chain axiom: ends with
definition: Process(P1) postively regulates process(P2) iff: P1 initiates P2, or P1 increases the the frequency of initiation of P2 or the magnitude or rate of output of P2.
term editor: Chris Mungall
definition source: causal-relations
OBO foundry unique label: positively regulates (process to process)
is positive form of: regulates
database_cross_reference: RO:0002213
has_obo_namespace: external
id: positively_regulates
shorthand: positively_regulates

capable of
type: ObjectProperty
sub property of: capable of part of
sub property of: functionally related to
domain: independent continuant
range: process
example of usage: mechanosensory neuron capable of detection of mechanical stimulus involved in sensory perception (GO:0050974)
example of usage: osteoclast SubClassOf 'capable of' some 'bone resorption'
definition: A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process.
term editor: Chris Mungall
alternative term: has function realized in
definition source: http://www.ncbi.nlm.nih.gov/pubmed/20123131
definition source: http://www.ncbi.nlm.nih.gov/pubmed/21208450
curator notes: For compatibility with BFO, this relation has a shortcut definition in which the expression "capable of some P" expands to "bearer_of (some realized_by only P)".
expand expression to: RO_0000053 some (RO_0000054 only ?Y)
database_cross_reference: RO:0002215
has_obo_namespace: uberon
id: capable_of
in_subset: eco subset
shorthand: capable_of

capable of part of
type: ObjectProperty
sub property of: functionally related to
sub property of: causal agent in process
property chain axiom: capable of
property chain axiom: part of
definition: c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p.
term editor: Chris Mungall
alternative term: has function in
expand expression to: RO_0000053 some (RO_0000054 only (BFO_0000050 some ?Y))
database_cross_reference: RO:0002216
has_obo_namespace: uberon
id: capable_of_part_of
shorthand: capable_of_part_of

Axiom
annotated source: capable of part of
annotated property: propertyChainAxiom
annotated target: capable of
annotated target: part of
RO_0002582: true

actively participates in
type: ObjectProperty
sub property of: participates in
inverse of: obsolete has active participant
definition: OBSOLETE x actively participates in y if and only if x participates in y and x realizes some active role
definition: x actively participates in y if and only if x participates in y and x realizes some active role
term editor: Chris Mungall
alternative term: agent in
comment: Obsoleted as the inverse property was obsoleted.
label: obsolete actively participates in
deprecated: true

obsolete has active participant
type: ObjectProperty
sub property of: has participant
example of usage: 'heart development' has active participant some Shh protein
has curation status: IAO_0000125
definition: x has participant y if and only if x realizes some active role that inheres in y
editor note: This may be obsoleted and replaced by the original 'has agent' relation
term editor: Chris Mungall
alternative term: has agent
in_subset: eco subset
deprecated: true

surrounded by
type: ObjectProperty
sub property of: adjacent to
inverse of: surrounds
has curation status: IAO_0000125
definition: x surrounded_by y if and only if (1) x is adjacent to y and for every region r that is adjacent to x, r overlaps y (2) the shared boundary between x and y occupies the majority of the outermost boundary of x
term editor: Chris Mungall
temporal interpretation: RO_0001901

adjacent to
type: ObjectProperty
sub property of: spatially disjoint from
type: SymmetricProperty
domain: independent continuant
range: independent continuant
example of usage: A caterpillar walking on the surface of a leaf is adjacent_to the leaf, if one of the caterpillar appendages is touching the leaf. In contrast, a butterfly flying close to a flower is not considered adjacent, unless there are any touching parts.
example of usage: The epidermis layer of a vertebrate is adjacent to the dermis.
example of usage: The plasma membrane of a cell is adjacent to the cytoplasm, and also to the cell lumen which the cytoplasm occupies.
example of usage: The skin of the forelimb is adjacent to the skin of the torso if these are considered anatomical subdivisions with a defined border. Otherwise a relation such as continuous_with would be used.
has curation status: IAO_0000125
definition: x adjacent to y if and only if x and y share a boundary.
definition: x adjacent_to y iff: x and y share a boundary
editor note: This relation acts as a join point with BSPO
term editor: Chris Mungall
temporal interpretation: RO_0001901
database_cross_reference: RO:0002220
has_obo_namespace: spatial
has_obo_namespace: uberon
id: adjacent_to
shorthand: adjacent_to
label: adjacent_to

Axiom
annotated source: adjacent to
annotated property: example of usage
annotated target: A caterpillar walking on the surface of a leaf is adjacent_to the leaf, if one of the caterpillar appendages is touching the leaf. In contrast, a butterfly flying close to a flower is not considered adjacent, unless there are any touching parts.

surrounds
type: ObjectProperty
sub property of: adjacent to
has curation status: IAO_0000125
definition: inverse of surrounded by
term editor: Chris Mungall
temporal interpretation: RO_0001901
in_subset: defined by inverse

temporally related to
type: ObjectProperty
domain: occurrent
range: occurrent
has curation status: IAO_0000125
term editor: Chris Mungall
definition source: Allen's interval algebra
curator notes: Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends.
source: https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit
in_subset: eco subset
comment: A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations.

starts
type: ObjectProperty
sub property of: part of
sub property of: temporally related to
inverse of: starts with
has curation status: IAO_0000125
definition: inverse of starts with
term editor: Chris Mungall
definition source: Allen
in_subset: eco subset

starts with
type: ObjectProperty
sub property of: has part
sub property of: temporally related to
type: TransitiveProperty
example of usage: Every insulin receptor signaling pathway starts with the binding of a ligand to the insulin receptor
has curation status: IAO_0000125
definition: x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
term editor: Chris Mungall
alternative term: started by
in_subset: eco subset

develops from part of
type: ObjectProperty
sub property of: develops_from
property chain axiom: directly develops from
property chain axiom: part of
has curation status: IAO_0000125
definition: x develops from part of y if and only if there exists some z such that x develops from z and z is part of y
term editor: Chris Mungall

develops in
type: ObjectProperty
sub property of: developmentally preceded by
domain: anatomical entity
property chain axiom: directly develops from
property chain axiom: located in
has curation status: IAO_0000125
definition: x develops_in y if x is located in y whilst x is developing
term editor: Chris Mungall
definition source: EHDAA2
definition source: Jonathan Bard, EHDAA2

ends
type: ObjectProperty
sub property of: part of
sub property of: temporally related to
inverse of: ends with
has curation status: IAO_0000125
definition: inverse of ends with
term editor: Chris Mungall
in_subset: eco subset

ends with
type: ObjectProperty
sub property of: has part
sub property of: temporally related to
type: TransitiveProperty
has curation status: IAO_0000125
definition: x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
term editor: Chris Mungall
alternative term: finished by
in_subset: eco subset

has start location
type: ObjectProperty
sub property of: has part that occurs in
domain: process
range: independent continuant
property chain axiom: starts with
property chain axiom: occurs in
has curation status: IAO_0000125
definition: x 'has starts location' y if and only if there exists some process z such that x 'starts with' z and z 'occurs in' y
term editor: Chris Mungall
alternative term: starts with process that occurs in
in_subset: eco subset

has end location
type: ObjectProperty
sub property of: has part that occurs in
domain: process
range: independent continuant
property chain axiom: ends with
property chain axiom: occurs in
has curation status: IAO_0000125
definition: x 'has end location' y if and only if there exists some process z such that x 'ends with' z and z 'occurs in' y
term editor: Chris Mungall
alternative term: ends with process that occurs in
in_subset: eco subset

has input
type: ObjectProperty
sub property of: has participant
inverse of: input of
domain: process
range: material entity
property chain axiom: starts with
has curation status: IAO_0000125
definition: p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p.
term editor: Chris Mungall
alternative term: consumes
in_subset: eco subset

has developmental contribution from
type: ObjectProperty
sub property of: developmentally preceded by
inverse of: developmentally_contributes_to
domain: anatomical entity
range: anatomical entity
property chain axiom: has part
property chain axiom: develops_from
example of usage: Mammalian thymus has developmental contribution from some pharyngeal pouch 3; Mammalian thymus has developmental contribution from some pharyngeal pouch 4 [Kardong]
has curation status: IAO_0000125
definition: x has developmental contribution from y iff x has some part z such that z develops from y
term editor: Chris Mungall
database_cross_reference: RO:0002254
has_obo_namespace: uberon
id: has_developmental_contribution_from
shorthand: has_developmental_contribution_from

developmentally_contributes_to
type: ObjectProperty
sub property of: developmentally succeeded by
sub property of: has potential to developmentally contribute to
property chain axiom: develops_into
property chain axiom: part of
has curation status: IAO_0000125
definition: inverse of has developmental contribution from
term editor: Chris Mungall
database_cross_reference: RO:0002255
has_obo_namespace: uberon
id: developmentally_contributes_to
in_subset: defined by inverse
shorthand: developmentally_contributes_to
label: developmentally contributes to

developmentally induced by
type: ObjectProperty
sub property of: developmentally preceded by
inverse of: developmentally induces
domain: anatomical structure
range: anatomical structure
has curation status: IAO_0000125
definition: t1 induced_by t2 if there is a process of developmental induction (GO:0031128) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor anatomical structure type T to T', where T' develops_from T
term editor: Chris Mungall
term editor: David Osumi-Sutherland
term editor: Melissa Haendel
alternative term: induced by
definition source: http://www.ncbi.nlm.nih.gov/pubmed/20064205
definition source: Developmental Biology, Gilbert, 8th edition, figure 6.5(F)
definition source: GO:0001759
curator notes: We place this under 'developmentally preceded by'. This placement should be examined in the context of reciprocal inductions[cjm]

developmentally induces
type: ObjectProperty
sub property of: developmentally succeeded by
sub property of: has potential to developmentally induce
has curation status: IAO_0000125
definition: Inverse of developmentally induced by
term editor: Chris Mungall

developmentally preceded by
type: ObjectProperty
sub property of: developmentally related to
inverse of: developmentally succeeded by
domain: continuant
range: continuant
has curation status: IAO_0000125
definition: Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p
editor note: false
term editor: Chris Mungall
curator notes: In general you should not use this relation to make assertions - use one of the more specific relations below this one
database_cross_reference: RO:0002258
has_obo_namespace: uberon
id: developmentally_preceded_by
shorthand: developmentally_preceded_by
comment: This relation groups together various other developmental relations. It is fairly generic, encompassing induction, developmental contribution and direct and transitive develops from

acts upstream of
type: ObjectProperty
sub property of: acts upstream of or within
property chain axiom: enables
property chain axiom: causally upstream of
example of usage: A faulty traffic light (material entity) whose malfunctioning (a process) is causally upstream of a traffic collision (a process): the traffic light acts upstream of the collision.
definition: c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes.

acts upstream of or within
type: ObjectProperty
sub property of: causal agent in process
property chain axiom: enables
property chain axiom: causally upstream of or within
example of usage: A gene product that has some activity, where that activity may be a part of a pathway or upstream of the pathway.
definition: c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process.
has_related_synonym: affects

developmentally replaces
type: ObjectProperty
sub property of: developmentally preceded by
has curation status: IAO_0000125
definition: x developmentally replaces y if and only if there is some developmental process that causes x to move or to cease to exist, and for the site that was occupied by x to become occupied by y, where y either comes into existence in this site or moves to this site from somewhere else
editor note: This relation is intended for cases such as when we have a bone element replacing its cartilage element precursor. Currently most AOs represent this using 'develops from'. We need to decide whether 'develops from' will be generic and encompass replacement, or whether we need a new name for a generic relation that encompasses replacement and development-via-cell-lineage
term editor: Chris Mungall
alternative term: replaces

developmentally succeeded by
type: ObjectProperty
sub property of: has developmental potential involving
has curation status: IAO_0000125
definition: Inverse of developmentally preceded by
term editor: Chris Mungall

part of developmental precursor of
type: ObjectProperty
sub property of: developmentally succeeded by
property chain axiom: part of
property chain axiom: directly develops into
example of usage: 'hypopharyngeal eminence' SubClassOf 'part of precursor of' some tongue
has curation status: IAO_0000125
term editor: Chris Mungall

causally upstream of, positive effect
type: ObjectProperty
sub property of: causally upstream of
sub property of: causally upstream of or within, positive effect
is positive form of: causally upstream of
creator: cjm
comment: holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y

causally upstream of, negative effect
type: ObjectProperty
sub property of: causally upstream of
sub property of: causally upstream of or within, negative effect
is negative form of: causally upstream of
creator: cjm
comment: holds between x and y if and only if x is causally upstream of y and the progression of x decreases the frequency, rate or extent of y

inheres in part of
type: ObjectProperty
sub property of: depends on
property chain axiom: inheres in
property chain axiom: part of
definition: q inheres in part of w if and only if there exists some p such that q inheres in p and p part of w.
editor note: Because part_of is transitive, inheres in is a sub-relation of inheres in part of
term editor: Chris Mungall
definition source: http://www.ncbi.nlm.nih.gov/pubmed/20064205
temporal interpretation: RO_0001901

Axiom
annotated source: inheres in part of
annotated property: propertyChainAxiom
annotated target: inheres in
annotated target: part of
RO_0002582: true

evolutionarily related to
type: ObjectProperty
definition: A relationship that holds via some environmental process
term editor: Chris Mungall
curator notes: Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving the process of evolution.

ecologically related to
type: ObjectProperty
definition: A relationship that is mediated in some way by the environment or environmental feature (ENVO:00002297)
editor note: Awaiting class for domain/range constraint, see: https://github.com/OBOFoundry/Experimental-OBO-Core/issues/6
term editor: Chris Mungall
curator notes: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving ecological interactions
in_subset: eco subset

confers advantage in
type: ObjectProperty
sub property of: ecologically related to
range: environmental system
editor note: An experimental relation currently used to connect a feature possessed by an organism (e.g. anatomical structure, biological process, phenotype or quality) to a habitat or environment in which that feature is well suited, adapted or provides a reproductive advantage for the organism. For example, fins to an aquatic environment. Usually this will mean that the structure is adapted for this environment, but we avoid saying this directly - primitive forms of the structure may not have evolved specifically for that environment (for example, early wings were not necessarily adapted for an aerial environment). Note also that this is a statement about the general class of structures - not every instance of a limb need confer an advantage for a terrestrial environment, e.g. if the limb is vestigial.
term editor: Chris Mungall
alternative term: adapted for
in_subset: eco subset

mereotopologically related to
type: ObjectProperty
definition: A mereological relationship or a topological relationship
term editor: Chris Mungall
curator notes: Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving parthood or connectivity relationships
temporal interpretation: RO_0001901

developmentally related to
type: ObjectProperty
definition: A relationship that holds between entities participating in some developmental process (GO:0032502)
term editor: Chris Mungall
curator notes: Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving organismal development

contributes to
type: ObjectProperty
sub property of: capable of part of
sub property of: part of structure that is capable of
example of usage: ATP citrate lyase (ACL) in Arabidopsis: it is a heterooctamer, composed of two types of subunits, ACLA and ACLB in a A(4)B(4) stoichiometry. Neither of the subunits expressed alone give ACL activity, but co-expression results in ACL activity. Both subunits contribute_to the ATP citrate lyase activity.
example of usage: Subunits of nuclear RNA polymerases: none of the individual subunits have RNA polymerase activity, yet all of these subunits contribute_to DNA-dependent RNA polymerase activity.
example of usage: eIF2: has three subunits (alpha, beta, gamma); one binds GTP; one binds RNA; the whole complex binds the ribosome (all three subunits are required for ribosome binding). So one subunit is annotated to GTP binding and one to RNA binding without qualifiers, and all three stand in the contributes_to relationship to "ribosome binding". And all three are part_of an eIF2 complex
editor note: We would like to say if and only if exists c', p' c part_of c' and c' capable_of p and c capable_of p' and p' part_of p then c contributes_to p However, this is not possible in OWL. We instead make this relation a sub-relation of the two chains, which gives us the inference in the one direction.
term editor: Chris Mungall
definition source: http://www.geneontology.org/GO.annotation.conventions.shtml#contributes_to
curator notes: In the context of the Gene Ontology, contributes_to may be used only with classes from the molecular function ontology.

enables
type: ObjectProperty
sub property of: capable of
inverse of: enabled by
property chain axiom: has part
property chain axiom: has component activity
example of usage: a particular instances of akt-2 enables some instance of protein kinase activity
term editor: Chris Mungall
alternative term: catalyzes
alternative term: executes
alternative term: has
alternative term: is catalyzing
alternative term: is executing
curator notes: This relation differs from the parent relation 'capable of' in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized.
curator notes: This relation is currently used experimentally by the Gene Ontology Consortium. It may not be stable and may be obsoleted at some future time.

functionally related to
type: ObjectProperty
definition: A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities.
term editor: Chris Mungall
curator notes: This is a grouping relation that collects relations used for the purpose of connecting structure and function
database_cross_reference: RO:0002328
has_obo_namespace: uberon
id: functionally_related_to
shorthand: functionally_related_to

part of structure that is capable of
type: ObjectProperty
sub property of: functionally related to
property chain axiom: part of
property chain axiom: capable of
definition: this relation holds between c and p when c is part of some c', and c' is capable of p.
term editor: Chris Mungall
alternative term: false
database_cross_reference: RO:0002329
has_obo_namespace: uberon
id: part_of_structure_that_is_capable_of
shorthand: part_of_structure_that_is_capable_of

Axiom
annotated source: part of structure that is capable of
annotated property: propertyChainAxiom
annotated target: part of
annotated target: capable of
is a defining property chain axiom: true

involved in
type: ObjectProperty
sub property of: participates in
sub property of: actively participates in
sub property of: involved in or involved in regulation of
property chain axiom: enables
property chain axiom: part of
definition: c involved_in p if and only if c enables some process p', and p' is part of p
term editor: Chris Mungall
alternative term: actively involved in
alternative term: enables part of

enabled by
type: ObjectProperty
sub property of: has participant
sub property of: functionally related to
definition: inverse of enables
term editor: Chris Mungall

regulated by
type: ObjectProperty
sub property of: causally downstream of or within
type: TransitiveProperty
domain: process
range: process
definition: inverse of regulates
term editor: Chris Mungall
OBO foundry unique label: regulated by (processual)
in_subset: defined by inverse

negatively regulated by
type: ObjectProperty
sub property of: regulated by
definition: inverse of negatively regulates
term editor: Chris Mungall
in_subset: defined by inverse

positively regulated by
type: ObjectProperty
sub property of: regulated by
definition: inverse of positively regulates
term editor: Chris Mungall
in_subset: defined by inverse

input of
type: ObjectProperty
sub property of: participates in
sub property of: functionally related to
definition: inverse of has input
term editor: Chris Mungall
database_cross_reference: RO:0002352
has_obo_namespace: uberon
id: input_of
in_subset: defined by inverse
in_subset: eco subset
shorthand: input_of

attached to
type: ObjectProperty
sub property of: connected to
sub property of: attached to part of
type: SymmetricProperty
definition: a is attached to b if and only if a and b are discrete objects or object parts, and there are physical connections between a and b such that a force pulling a will move b, or a force pulling b will move a
term editor: Chris Mungall
OBO foundry unique label: attached to (anatomical structure to anatomical structure)
in_subset: eco subset

has muscle origin
type: ObjectProperty
sub property of: attached to
sub property of: biomechanically related to
domain: anatomical structure
definition: m has_muscle_origin s iff m is attached_to s, and it is the case that when m contracts, s does not move. The site of the origin tends to be more proximal and have greater mass than what the other end attaches to.
term editor: Chris Mungall
definition source: Wikipedia:Insertion_(anatomy)

Axiom
annotated source: has muscle origin
annotated property: domain
annotated target: anatomical structure
comment: We need to import uberon muscle to create a stricter domain constraint

has muscle insertion
type: ObjectProperty
sub property of: attached to
sub property of: biomechanically related to
domain: anatomical structure
definition: m has_muscle_insertion s iff m is attaches_to s, and it is the case that when m contracts, s moves. Insertions are usually connections of muscle via tendon to bone.
term editor: Chris Mungall
definition source: Wikipedia:Insertion_(anatomy)

Axiom
annotated source: has muscle insertion
annotated property: domain
annotated target: anatomical structure
editor note: We need to import uberon muscle into RO to use as a stricter domain constraint

derived from ancestral fusion of
type: ObjectProperty
sub property of: derived by descent from
example of usage: false
has curation status: IAO_0000428
definition: x has_fused_element y iff: there exists some z : x has_part z, z homologous_to y, and y is a distinct element, the boundary between x and z is largely fiat
term editor: Chris Mungall
definition source: http://www.ncbi.nlm.nih.gov/pubmed/22293552
has_broad_synonym: has fused element
comment: A has_fused_element B does not imply that A has_part some B: rather than A has_part some B', where B' that has some evolutionary relationship to B.

spatially coextensive with
type: ObjectProperty
sub property of: overlaps
property chain axiom: located in
property chain axiom:
  inverse of: located in
example of usage: A lump of clay and a statue
definition: x spatially_coextensive_with y if and inly if x and y have the same location
term editor: Chris Mungall
curator notes: This relation is added for formal completeness. It is unlikely to be used in many practical scenarios

has developmental potential involving
type: ObjectProperty
sub property of: developmentally related to
domain: anatomical entity
range: anatomical entity
has curation status: IAO_0000428
definition: x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction).
term editor: Chris Mungall

has potential to developmentally contribute to
type: ObjectProperty
sub property of: has developmental potential involving
has curation status: IAO_0000428
definition: x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y
term editor: Chris Mungall
database_cross_reference: RO:0002385
has_obo_namespace: uberon
id: has_potential_to_developmentally_contribute_to
shorthand: has_potential_to_developmentally_contribute_to

has potential to developmentally induce
type: ObjectProperty
sub property of: has developmental potential involving
has curation status: IAO_0000428
definition: x has potential to developmentally induce y iff x developmentally induces y or x is capable of developmentally inducing y
term editor: Chris Mungall

has potential to develop into
type: ObjectProperty
sub property of: has developmental potential involving
has curation status: IAO_0000428
definition: x has the potential to develop into y iff x develops into y or if x is capable of developing into y
term editor: Chris Mungall
database_cross_reference: RO:0002387
has_obo_namespace: uberon
id: has_potential_to_develop_into
shorthand: has_potential_to_develop_into

has potential to directly develop into
type: ObjectProperty
sub property of: has potential to develop into
has curation status: IAO_0000428
definition: x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y
term editor: Chris Mungall
database_cross_reference: RO:0002388
has_obo_namespace: uberon
id: has_potential_to_directly_develop_into
shorthand: has_potential_to_directly_develop_into

causally downstream of
type: ObjectProperty
sub property of: preceded_by
sub property of: causally downstream of or within
inverse of: causally upstream of
has curation status: IAO_0000428
definition: inverse of upstream of
term editor: Chris Mungall

immediately causally downstream of
type: ObjectProperty
sub property of: immediately_preceded_by
sub property of: causally downstream of
inverse of: immediately causally upstream of
has curation status: IAO_0000428
term editor: Chris Mungall

causally related to
type: ObjectProperty
has curation status: IAO_0000428
definition: This relation groups causal relations between material entities and causal relations between processes
editor note: This branch of the ontology deals with causal relations between entities. It is divided into two branches: causal relations between occurrents/processes, and causal relations between material entities. We take an 'activity flow-centric approach', with the former as primary, and define causal relations between material entities in terms of causal relations between occurrents. To define causal relations in an activity-flow type network, we make use of 3 primitives: * Temporal: how do the intervals of the two occurrents relate? * Is the causal relation regulatory? * Is the influence positive or negative The first of these can be formalized in terms of the Allen Interval Algebra. Informally, the 3 bins we care about are 'direct', 'indirect' or overlapping. Note that all causal relations should be classified under a RO temporal relation (see the branch under 'temporally related to'). Note that all causal relations are temporal, but not all temporal relations are causal. Two occurrents can be related in time without being causally connected. We take causal influence to be primitive, elucidated as being such that has the upstream changed, some qualities of the donwstream would necessarily be modified. For the second, we consider a relationship to be regulatory if the system in which the activities occur is capable of altering the relationship to achieve some objective. This could include changing the rate of production of a molecule. For the third, we consider the effect of the upstream process on the output(s) of the downstream process. If the level of output is increased, or the rate of production of the output is increased, then the direction is increased. Direction can be positive, negative or neutral or capable of either direction. Two positives in succession yield a positive, two negatives in succession yield a positive, otherwise the default assumption is that the net effect is canceled and the influence is neutral. Each of these 3 primitives can be composed to yiel…
term editor: Chris Mungall
curator notes: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.

causally upstream of
type: ObjectProperty
sub property of: precedes
sub property of: causally upstream of or within
type: TransitiveProperty
has curation status: IAO_0000428
definition: p is causally upstream of q if and only if p precedes q and p and q are linked in a causal chain
term editor: Chris Mungall

immediately causally upstream of
type: ObjectProperty
sub property of: immediately precedes
sub property of: causally upstream of
has curation status: IAO_0000428
definition: p is immediately causally upstream of q iff both (a) p immediately precedes q and (b) p is causally upstream of q. In addition, the output of p must be an input of q.
term editor: Chris Mungall
is direct form of: causally upstream of

causally upstream of or within
type: ObjectProperty
sub property of: causal relation between processes
inverse of: causally downstream of or within
type: TransitiveProperty
definition: p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q.
editor note: We would like to make this disjoint with 'preceded by', but this is prohibited in OWL2
term editor: Chris Mungall
alternative term: influences (processual)
has_related_synonym: affects

causally downstream of or within
type: ObjectProperty
sub property of: causal relation between processes
type: TransitiveProperty
definition: inverse of causally upstream of or within
term editor: Chris Mungall
definition source: causal-relations
in_subset: defined by inverse

involved in regulation of
type: ObjectProperty
sub property of: acts upstream of
sub property of: involved in or involved in regulation of
property chain axiom: enables
property chain axiom: regulates
property chain axiom: involved in
definition: c involved in regulation of p if c is involved in some p' and p' regulates some p
term editor: Chris Mungall

involved in positive regulation of
type: ObjectProperty
sub property of: involved in regulation of
property chain axiom: enables
property chain axiom: positively regulates
property chain axiom: involved in
definition: c involved in regulation of p if c is involved in some p' and p' positively regulates some p
term editor: Chris Mungall
is positive form of: involved in regulation of

involved in negative regulation of
type: ObjectProperty
sub property of: involved in regulation of
property chain axiom: enables
property chain axiom: negatively regulates
property chain axiom: involved in
definition: c involved in regulation of p if c is involved in some p' and p' negatively regulates some p
term editor: Chris Mungall
is negative form of: involved in regulation of

involved in or involved in regulation of
type: ObjectProperty
sub property of: acts upstream of or within
sub property of: functionally related to
sub property of: causal agent in process
definition: c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p
editor note: OWL does not allow defining object properties via a Union
term editor: Chris Mungall
alternative term: involved in or reguates

is active in
type: ObjectProperty
sub property of: overlaps
sub property of: functionally related to
property chain axiom: enables
property chain axiom: occurs in
example of usage: A protein that enables activity in a cytosol.
definition: c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure.
term editor: Chris Mungall
alternative term: executes activity in
has_exact_synonym: enables activity in

Axiom
annotated source: is active in
annotated property: propertyChainAxiom
annotated target: enables
annotated target: occurs in
is a defining property chain axiom: true

Axiom
annotated source: is active in
annotated property: definition
annotated target: c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure.
database_cross_reference: GOC:cjm
database_cross_reference: GOC:dos

interacts with
type: ObjectProperty
type: SymmetricProperty
domain: material entity
range: material entity
definition: A relationship that holds between two entities in which the processes executed by the two entities are causally connected.
editor note: Considering relabeling as 'pairwise interacts with'
editor note: This relation and all sub-relations can be applied to either (1) pairs of entities that are interacting at any moment of time (2) populations or species of entity whose members have the disposition to interact (3) classes whose members have the disposition to interact.
term editor: Chris Mungall
curator notes: Note that this relationship type, and sub-relationship types may be redundant with process terms from other ontologies. For example, the symbiotic relationship hierarchy parallels GO. The relations are provided as a convenient shortcut. Consider using the more expressive processual form to capture your data. In the future, these relations will be linked to their cognate processes through rules.
has_exact_synonym: in pairwise interaction with
in_subset: eco subset

molecularly interacts with
type: ObjectProperty
sub property of: interacts with
type: SymmetricProperty
definition: An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other.
term editor: Chris Mungall
alternative term: binds
alternative term: molecularly binds with

phosphorylates
type: ObjectProperty
sub property of: molecularly interacts with
editor note: Axiomatization to GO to be added later
term editor: Chris Mungall
alternative term: An interaction relation between x and y in which x catalyzes a reaction in which a phosphate group is added to y.

activity directly regulates activity of
type: ObjectProperty
sub property of: molecularly interacts with
sub property of: causally influences
sub property of: regulates activity of
domain: material entity
range: material entity
property chain axiom: enables
property chain axiom: regulates
property chain axiom: enabled by
definition: Holds between molecular entities A and B where A can physically interact with B and in doing so regulates a process that B is capable of. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B.
definition: The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B. A and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B.
term editor: Chris Mungall
term editor: Vasundra Touré
has_exact_synonym: molecularly controls
label: directly regulates activity of

activity directly negatively regulates activity of
type: ObjectProperty
sub property of: activity directly regulates activity of
domain: material entity
range: material entity
property chain axiom: enables
property chain axiom: directly negatively regulates
property chain axiom: enabled by
definition: Holds between molecular entities A and B where A can physically interact with B and in doing so negatively regulates a process that B is capable of. For example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B.
definition: The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B.
term editor: Chris Mungall
term editor: Vasundra Touré
alternative term: directly inhibits
alternative term: inhibits
has_exact_synonym: molecularly decreases activity of
label: directly negatively regulates activity of

activity directly positively regulates activity of
type: ObjectProperty
sub property of: activity directly regulates activity of
domain: material entity
range: material entity
property chain axiom: enables
property chain axiom: directly positively regulates
property chain axiom: enabled by
definition: Holds between molecular entities A and B where A can physically interact with B and in doing so positively regulates a process that B is capable of. For example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B.
definition: The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B.
term editor: Chris Mungall
term editor: Vasundra Touré
alternative term: activates
alternative term: directly activates
has_exact_synonym: molecularly increases activity of
label: directly positively regulates activity of

helper property (not for use in curation)
type: ObjectProperty
term editor: Chris Mungall
curator notes: This property or its subproperties is not to be used directly. These properties exist as helper properties that are used to support OWL reasoning.

is symbiosis
type: ObjectProperty
sub property of: interaction relation helper property
term editor: Chris Mungall

composed primarily of
type: ObjectProperty
sub property of: has part
domain: material entity
range: material entity
example of usage: 'otolith organ' SubClassOf 'composed primarily of' some 'calcium carbonate'
definition: x composed_primarily_of y if and only if more than half of the mass of x is made from y or units of the same type as y.
term editor: Chris Mungall
definition source: http://www.ncbi.nlm.nih.gov/pubmed/22293552
temporal interpretation: RO_0001901
in_subset: eco subset

has part that occurs in
type: ObjectProperty
domain: occurrent
range: independent continuant
property chain axiom: has part
property chain axiom: occurs in
definition: p has part that occurs in c if and only if there exists some p1, such that p has_part p1, and p1 occurs in c.
term editor: Chris Mungall
in_subset: eco subset

Axiom
annotated source: has part that occurs in
annotated property: propertyChainAxiom
annotated target: has part
annotated target: occurs in
is a defining property chain axiom: true

is kinase activity
type: ObjectProperty
sub property of: molecular interaction relation helper property
term editor: Chris Mungall

relation between physical entity and a process or stage
type: ObjectProperty
domain: independent continuant
domain: Class
  union of: material anatomical entity
  union of: immaterial anatomical entity
range: occurrent
term editor: Chris Mungall
curator notes: Do not use this relation directly. It is ended as a grouping for a diverse set of relations, typically connecting an anatomical entity to a biological process or developmental stage.

existence starts during
type: ObjectProperty
sub property of: existence overlaps
sub property of: existence starts during or after
property chain axiom: part of
property chain axiom: existence starts at end of
definition: x existence starts during y if and only if the time point at which x starts is after or equivalent to the time point at which y starts and before or equivalent to the time point at which y ends. Formally: x existence starts during y iff α(x) >= α(y) & α(x) <= ω(y).
term editor: Chris Mungall

existence overlaps
type: ObjectProperty
sub property of: relation between physical entity and a process or stage
definition: x existence overlaps y if and only if either (a) the start of x is part of y or (b) the end of x is part of y. Formally: x existence starts and ends during y iff (α(x) >= α(y) & α(x) <= ω(y)) OR (ω(x) <= ω(y) & ω(x) >= α(y))
term editor: Chris Mungall
comment: The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription.

existence ends during
type: ObjectProperty
sub property of: existence overlaps
sub property of: existence ends during or before
property chain axiom: part of
property chain axiom: existence ends at start of
definition: x existence ends during y if and only if the time point at which x ends is before or equivalent to the time point at which y ends and after or equivalent to the point at which y starts. Formally: x existence ends during y iff ω(x) <= ω(y) and ω(x) >= α(y).
term editor: Chris Mungall
comment: The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription.

existence starts during or after
type: ObjectProperty
sub property of: relation between physical entity and a process or stage
property chain axiom: part of
property chain axiom: developmentally preceded by
property chain axiom: preceded_by
property chain axiom: simultaneous with
property chain axiom: existence starts at end of
property chain axiom:
  inverse of: existence starts at end of
definition: x existence starts during or after y if and only if the time point at which x starts is after or equivalent to the time point at which y starts. Formally: x existence starts during or after y iff α (x) >= α (y).
term editor: Chris Mungall
database_cross_reference: RO:0002496
has_obo_namespace: uberon
id: existence_starts_during_or_after
shorthand: existence_starts_during_or_after
comment: The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription.

existence ends during or before
type: ObjectProperty
sub property of: relation between physical entity and a process or stage
property chain axiom: part of
property chain axiom: developmentally succeeded by
property chain axiom: precedes
property chain axiom: simultaneous with
property chain axiom: existence ends at start of
property chain axiom:
  inverse of: existence ends at start of
definition: x existence ends during or before y if and only if the time point at which x ends is before or equivalent to the time point at which y ends.
term editor: Chris Mungall
database_cross_reference: RO:0002497
has_obo_namespace: uberon
id: existence_ends_during_or_before
shorthand: existence_ends_during_or_before
comment: The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription.

causal agent in process
type: ObjectProperty
sub property of: causal relation between material entity and a process
inverse of: process has causal agent
definition: A relationship between a material entity and a process where the material entity has some causal role that influences the process
definition source: causal-relations

causal relation between processes
type: ObjectProperty
sub property of: causally related to
domain: occurrent
range: occurrent
definition: p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q.
term editor: Chris Mungall
definition source: causal-relations
curator notes: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.

depends on
type: ObjectProperty
term editor: Chris Mungall

towards
type: ObjectProperty
sub property of: depends on
definition: q towards e2 if and only if q is a relational quality such that q inheres-in some e, and e != e2 and q is dependent on e2
editor note: This relation is provided in order to support the use of relational qualities such as 'concentration of'; for example, the concentration of C in V is a quality that inheres in V, but pertains to C.
term editor: Chris Mungall
definition source: http://www.ncbi.nlm.nih.gov/pubmed/20064205

causal relation between entities
type: ObjectProperty
sub property of: causally related to
domain: continuant
domain: material entity
range: continuant
range: material entity
editor note: The intent is that the process branch of the causal property hierarchy is primary (causal relations hold between occurrents/processes), and that the material branch is defined in terms of the process branch
term editor: Chris Mungall
definition source: causal-relations
curator notes: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.
label: causal relation between material entities

causally influenced by
type: ObjectProperty
sub property of: causal relation between entities
inverse of: causally influences
term editor: Chris Mungall
definition source: causal-relations
OBO foundry unique label: causally influenced by (entity-centric)
OBO foundry unique label: causally influenced by (material entity to material entity)

interaction relation helper property
type: ObjectProperty
sub property of: helper property (not for use in curation)
term editor: Chris Mungall

molecular interaction relation helper property
type: ObjectProperty
sub property of: interaction relation helper property
term editor: Chris Mungall

causally influences
type: ObjectProperty
sub property of: causal relation between entities
domain: continuant
range: continuant
property chain axiom: enables
property chain axiom: causally upstream of
property chain axiom: has input
property chain axiom: enabled by
definition: Holds between materal entities a and b if the activity of a is causally upstream of the activity of b, or causally upstream of a an activity that modifies b
definition: The entity or characteristic A is causally upstream of the entity or characteristic B, A having an effect on B. An entity corresponds to any biological type of entity as long as a mass is measurable. A characteristic corresponds to a particular specificity of an entity (e.g., phenotype, shape, size).
term editor: Chris Mungall
term editor: Vasundra Touré
definition source: causal-relations
OBO foundry unique label: causally influences (entity-centric)
OBO foundry unique label: causally influences (material entity to material entity)

biomechanically related to
type: ObjectProperty
sub property of: functionally related to
domain: anatomical structure
range: anatomical structure
definition: A relation that holds between elements of a musculoskeletal system or its analogs.
term editor: Chris Mungall
curator notes: Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving the biomechanical processes.

has modifier
type: ObjectProperty
domain: specifically dependent continuant
range: specifically dependent continuant
definition: A relation that holds between an attribute or a qualifier and another attribute.
term editor: Chris Mungall
definition source: http://www.ncbi.nlm.nih.gov/pubmed/20064205
curator notes: This relation is intended to be used in combination with PATO, to be able to refine PATO quality classes using modifiers such as 'abnormal' and 'normal'. It has yet to be formally aligned into an ontological framework; it's not clear what the ontological status of the "modifiers" are.
in_subset: eco subset

directly regulates
type: ObjectProperty
sub property of: regulates
sub property of: immediately causally upstream of
definition: Process(P1) directly regulates process(P2) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2.
term editor: Chris Mungall
definition source: causal-relations
OBO foundry unique label: directly regulates (processual)
is direct form of: regulates

existence starts at end of
type: ObjectProperty
sub property of: existence starts during or after
definition: holds between x and y if and only if the time point at which x starts is equivalent to the time point at which y ends. Formally: iff α(x) = ω(y).

has part structure that is capable of
type: ObjectProperty
sub property of: functionally related to
sub property of: causal relation between material entity and a process
property chain axiom: has part
property chain axiom: capable of
example of usage: gland SubClassOf 'has part structure that is capable of' some 'secretion by cell'
definition: s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p
term editor: Chris Mungall

existence ends at start of
type: ObjectProperty
sub property of: existence ends during or before
definition: holds between x and y if and only if the time point at which x ends is equivalent to the time point at which y starts. Formally: iff ω(x) = α(y).

causal relation between material entity and a process
type: ObjectProperty
sub property of: causally related to
domain: material entity
range: process
definition: A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity.
editor note: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.
term editor: Chris Mungall
definition source: causal-relations

capable of regulating
type: ObjectProperty
sub property of: causal agent in process
property chain axiom: capable of
property chain axiom: regulates
example of usage: pyrethroid -> growth
definition: Holds between c and p if and only if c is capable of some activity a, and a regulates p.
definition source: causal-relations

capable of negatively regulating
type: ObjectProperty
sub property of: capable of regulating
property chain axiom: capable of
property chain axiom: negatively regulates
definition: Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p.
definition source: causal-relations

capable of positively regulating
type: ObjectProperty
sub property of: capable of regulating
property chain axiom: capable of
property chain axiom: positively regulates
example of usage: renin -> arteriolar smooth muscle contraction
definition: Holds between c and p if and only if c is capable of some activity a, and a positively regulates p.
definition source: causal-relations

process has causal agent
type: ObjectProperty
sub property of: causally related to
definition: Inverse of 'causal agent in process'
definition source: causal-relations

obsolete related via dependence to
type: ObjectProperty
definition: A relationship that holds between two entities, where the relationship holds based on the presence or absence of statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes.
curator notes: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.
deprecated: true

directly positively regulates
type: ObjectProperty
sub property of: positively regulates
sub property of: directly regulates
definition: Process(P1) directly postively regulates process(P2) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P1 directly positively regulates P2.
definition source: causal-relations
OBO foundry unique label: directly positively regulates (process to process)
is positive form of: directly regulates

directly negatively regulates
type: ObjectProperty
sub property of: negatively regulates
sub property of: directly regulates
definition: Process(P1) directly negatively regulates process(P2) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P1 directly negatively regulates P2.
definition source: causal-relations
OBO foundry unique label: directly negatively regulates (process to process)
is negative form of: directly regulates

produces
type: ObjectProperty
inverse of: produced_by
domain: material entity
range: material entity
has curation status: IAO_0000125
definition: a produces b if some process that occurs_in a has_output b, where a and b are material entities. Examples: hybridoma cell line produces monoclonal antibody reagent; chondroblast produces avascular GAG-rich matrix.
term editor: Melissa Haendel
database_cross_reference: RO:0003000
has_obo_namespace: uberon
id: produces
in_subset: eco subset
shorthand: produces
comment: Note that this definition doesn't quite distinguish the output of a transformation process from a production process, which is related to the identity/granularity issue.

produced_by
type: ObjectProperty
domain: material entity
range: material entity
has curation status: IAO_0000125
definition: a produced_by b iff some process that occurs_in b has_output a.
term editor: Melissa Haendel
database_cross_reference: RO:0003001
has_obo_namespace: uberon
id: produced_by
in_subset: eco subset
shorthand: produced_by
label: produced by

disease has feature
type: ObjectProperty
sub property of: disease relationship
domain: OGMS_0000031
range: Class
  union of: OGMS_0000031
  union of: UPHENO_0001001
definition: A relationship between a disease and some feature of that disease, where the feature is either a phenotype or an isolated disease.
created by: cjm
creation date: 2017-12-26T19:50:53Z

enables subfunction
type: ObjectProperty
sub property of: functionally related to
property chain axiom: enables
property chain axiom: has part
definition: Holds between an entity and an process P where the entity enables some larger compound process, and that larger process has-part P.
created by: cjm
creation date: 2018-01-25T23:20:13Z

acts upstream of or within, positive effect
type: ObjectProperty
sub property of: acts upstream of or within
property chain axiom: enables
property chain axiom: causally upstream of or within, positive effect
is positive form of: acts upstream of or within
created by: cjm
creation date: 2018-01-26T23:49:30Z

acts upstream of or within, negative effect
type: ObjectProperty
sub property of: acts upstream of or within
property chain axiom: enables
property chain axiom: causally upstream of or within, negative effect
is negative form of: acts upstream of or within
created by: cjm
creation date: 2018-01-26T23:49:51Z

acts upstream of, positive effect
type: ObjectProperty
sub property of: acts upstream of
sub property of: acts upstream of or within, positive effect
property chain axiom: enables
property chain axiom: causally upstream of, positive effect
definition: c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive
is positive form of: acts upstream of
created by: cjm
creation date: 2018-01-26T23:53:14Z

acts upstream of, negative effect
type: ObjectProperty
sub property of: acts upstream of
sub property of: acts upstream of or within, negative effect
property chain axiom: enables
property chain axiom: causally upstream of, negative effect
definition: c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative
is negative form of: acts upstream of
created by: cjm
creation date: 2018-01-26T23:53:22Z

causally upstream of or within, negative effect
type: ObjectProperty
sub property of: causally upstream of or within
is negative form of: causally upstream of or within
created by: cjm
creation date: 2018-03-13T23:55:05Z

causally upstream of or within, positive effect
type: ObjectProperty
sub property of: causally upstream of or within
is positive form of: causally upstream of or within
created by: cjm
creation date: 2018-03-13T23:55:19Z

regulates activity of
type: ObjectProperty
sub property of: causally influences
domain: material entity
range: material entity
definition: The entity A has an activity that regulates an activity of the entity B. For example, A and B are gene products where the catalytic activity of A regulates the kinase activity of B.
term editor: Vasundra Touré

disease relationship
type: ObjectProperty
definition: This relation groups relations between diseases and any other kind of entity.
curator notes: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, in which the subject or object is a disease.
created by: cjm
creation date: 2018-09-26T00:00:32Z

parallel to
type: ObjectProperty
definition: x is parallel t y iff x and y are lines or planes which when extended indefinitely do not cross.
has_obo_namespace: spatial
id: parallel_to

Axiom
annotated source: parallel to
annotated property: definition
annotated target: x is parallel t y iff x and y are lines or planes which when extended indefinitely do not cross.
database_cross_reference: BSPO:curators

correlates_with
type: ObjectProperty
has_obo_namespace: quality
id: correlates_with

decreased_in_magnitude_relative_to
type: ObjectProperty
sub property of: different_in_magnitude_relative_to
type: TransitiveProperty
domain: PATO_0000001
range: PATO_0000001
definition: q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) < magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
has_obo_namespace: quality
id: decreased_in_magnitude_relative_to
comment: This relation is used to determine the 'directionality' of relative qualities such as 'decreased strength', relative to the parent type, 'strength'.

Axiom
annotated source: decreased_in_magnitude_relative_to
annotated property: definition
annotated target: q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) < magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
database_cross_reference: PATOC:CJM

different_in_magnitude_relative_to
type: ObjectProperty
domain: PATO_0000001
range: PATO_0000001
definition: q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
has_obo_namespace: quality
id: different_in_magnitude_relative_to

Axiom
annotated source: different_in_magnitude_relative_to
annotated property: definition
annotated target: q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
database_cross_reference: PATOC:CJM

has_cross_section
type: ObjectProperty
definition: s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2.
has_obo_namespace: quality
id: has_cross_section
comment: Example: a spherical object has the quality of being spherical, and the spherical quality has_cross_section round.

Axiom
annotated source: has_cross_section
annotated property: definition
annotated target: s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2.
database_cross_reference: PATOC:CJM

increased_in_magnitude_relative_to
type: ObjectProperty
sub property of: different_in_magnitude_relative_to
type: TransitiveProperty
domain: PATO_0000001
range: PATO_0000001
definition: q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
has_obo_namespace: quality
id: increased_in_magnitude_relative_to
comment: This relation is used to determine the 'directionality' of relative qualities such as 'increased strength', relative to the parent type, 'strength'.

Axiom
annotated source: increased_in_magnitude_relative_to
annotated property: definition
annotated target: q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
database_cross_reference: PATOC:CJM

reciprocal_of
type: ObjectProperty
definition: q1 reciprocal_of q2 if and only if : q1 and q2 are relational qualities and a phenotype e q1 e2 mutually implies a phenotype e2 q2 e.
has_obo_namespace: quality
id: reciprocal_of
comment: There are frequently two ways to state the same thing: we can say 'spermatocyte lacks asters' or 'asters absent from spermatocyte'. In this case the quality is 'lacking all parts of type' - it is a (relational) quality of the spermatocyte, and it is with respect to instances of 'aster'. One of the popular requirements of PATO is that it continue to support 'absent', so we need to relate statements which use this quality to the 'lacking all parts of type' quality.

Axiom
annotated source: reciprocal_of
annotated property: definition
annotated target: q1 reciprocal_of q2 if and only if : q1 and q2 are relational qualities and a phenotype e q1 e2 mutually implies a phenotype e2 q2 e.
database_cross_reference: PATOC:CJM

continuant
type: Class
subclass of: Restriction
  on property: part of
  all values from: continuant
disjoint with: occurrent
disjoint with: Restriction
  on property: part of
  some values from: occurrent
definition: An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts.

occurrent
type: Class
subclass of: Restriction
  on property: part of
  all values from: occurrent
disjoint with: Restriction
  on property: part of
  some values from: continuant
definition: An entity that has temporal parts and that happens, unfolds or develops through time.

independent continuant
type: Class
subclass of: continuant
subclass of: Restriction
  on property: part of
  all values from: independent continuant
disjoint with: specifically dependent continuant
disjoint with: generically dependent continuant
definition: A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.

spatial region
type: Class
subclass of: immaterial entity

process
type: Class
subclass of: occurrent
definition: An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.

disposition
type: Class
subclass of: realizable entity

realizable entity
type: Class
subclass of: specifically dependent continuant
subclass of: Restriction
  on property: part of
  all values from: realizable entity
disjoint with: quality
definition: A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances.

quality
type: Class
subclass of: specifically dependent continuant
subclass of: Restriction
  on property: part of
  all values from: quality

specifically dependent continuant
type: Class
subclass of: continuant
subclass of: Restriction
  on property: part of
  all values from: specifically dependent continuant
disjoint with: generically dependent continuant
definition: A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.

generically dependent continuant
type: Class
subclass of: continuant
subclass of: Restriction
  on property: part of
  all values from: generically dependent continuant
definition: A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time.

material entity
type: Class
subclass of: independent continuant
disjoint with: immaterial entity
disjoint with: Restriction
  on property: part of
  some values from: immaterial entity
definition: An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time.

immaterial entity
type: Class
subclass of: independent continuant
disjoint with: Restriction
  on property: has part
  some values from: material entity

anatomical surface
type: Class
subclass of: anatomical boundary
definition: A 2D surface of an anatomical continuant.
database_cross_reference: FMA:24137
has_exact_synonym: surface
has_obo_namespace: spatial
id: BSPO:0000005
comment: to be merged into CARO

Axiom
annotated source: anatomical surface
annotated property: definition
annotated target: A 2D surface of an anatomical continuant.
database_cross_reference: BSPO:cjm

anatomical axis
type: Class
subclass of: anatomical line
subclass of: Restriction
  on property: passes through
  some values from: anatomical entity
definition: A straight line through space, intersecting an anatomical entity.
has_obo_namespace: spatial
id: BSPO:0000010
comment: Axis directions are defined in terms of axes.

Axiom
annotated source: anatomical axis
annotated property: definition
annotated target: A straight line through space, intersecting an anatomical entity.
database_cross_reference: BSPO:cjm

anterior-posterior axis
type: Class
equivalent class: Class
  intersection of: anatomical axis
  intersection of: Restriction
    on property: orthogonal to
    some values from: transverse plane
subclass of: anatomical axis
subclass of: Restriction
  on property: approximately perpendicular to
  some values from: dorsal-ventral axis
subclass of: Restriction
  on property: orthogonal to
  some values from: transverse plane
definition: An axis that extends through an organism from head end to opposite end of body or tail.
has_exact_synonym: A-P axis
has_exact_synonym: AP axis
has_exact_synonym: anteroposterior axis
has_narrow_synonym: cephalocaudal axis
has_narrow_synonym: craniocaudal axis
has_narrow_synonym: rostral/caudal
has_narrow_synonym: rostrocaudal axis
has_obo_namespace: spatial
has_related_synonym: longitudinal axis
id: BSPO:0000013
comment: In sponges, AP is used to indicate the direction of movement [in larval stage] (as it is in other metazoans that move, e.g., the basal bilaterians). [PM]

Axiom
annotated source: anterior-posterior axis
annotated property: definition
annotated target: An axis that extends through an organism from head end to opposite end of body or tail.
database_cross_reference: BSPO:cjm

Axiom
annotated source: anterior-posterior axis
annotated property: has_narrow_synonym
annotated target: cephalocaudal axis
database_cross_reference: http://en.wikipedia.org/wiki/Anatomical_terms_of_location

Axiom
annotated source: anterior-posterior axis
annotated property: has_narrow_synonym
annotated target: craniocaudal axis
has_synonym_type: synonym typically used in the context of vertebrate anatomy

Axiom
annotated source: anterior-posterior axis
annotated property: has_narrow_synonym
annotated target: rostral/caudal
has_synonym_type: synonym typically used in the context of vertebrate anatomy

Axiom
annotated source: anterior-posterior axis
annotated property: has_narrow_synonym
annotated target: rostrocaudal axis
has_synonym_type: synonym typically used in the context of vertebrate anatomy

apical-basal axis relative to substrate
type: Class
subclass of: anatomical axis
definition: An axis that extends through an organism or organism part from the part of the organism or organism part attached to a substrate (basal) to the furthest from the attachment (apical). Note that the apical-basal axis is often used for organismal parts where there is attachment via a basal lamina or other structure.
has_exact_synonym: apical/basal
has_obo_namespace: spatial
has_related_synonym: longitudinal axis
id: BSPO:0000014

Axiom
annotated source: apical-basal axis relative to substrate
annotated property: definition
annotated target: An axis that extends through an organism or organism part from the part of the organism or organism part attached to a substrate (basal) to the furthest from the attachment (apical). Note that the apical-basal axis is often used for organismal parts where there is attachment via a basal lamina or other structure.
database_cross_reference: BSPO:mah

proximal-distal axis
type: Class
subclass of: anatomical axis
definition: An axis that extends from the point of attachment of a structure (proximal) to the point furthest away from the plane of attachment (distal).
has_exact_synonym: proximal/distal
has_exact_synonym: proximodistal
has_obo_namespace: spatial
id: BSPO:0000015
comment: In some communities, proximal and distal are used when specifying the position of parts of elements that are contained within the body, such as gill arches or vertebral spines. In these cases, use of the classes medial-lateral axis or medial-external axis are more appropriate.

Axiom
annotated source: proximal-distal axis
annotated property: definition
annotated target: An axis that extends from the point of attachment of a structure (proximal) to the point furthest away from the plane of attachment (distal).
database_cross_reference: BSPO:curators
database_cross_reference: http://en.wikipedia.org/wiki/Anatomical_terms_of_location

dorsal-ventral axis
type: Class
equivalent class: Class
  intersection of: anatomical axis
  intersection of: Restriction
    on property: orthogonal to
    some values from: horizontal plane
subclass of: anatomical axis
subclass of: Restriction
  on property: orthogonal to
  some values from: horizontal plane
definition: An axis that is approximately perpendicular to the anterior-posterior axis and that extends through the horizontal plane of the body.
has_exact_synonym: D-V axis
has_exact_synonym: DV axis
has_exact_synonym: dorsoventral axis
has_narrow_synonym: anterior-posterior axis
has_obo_namespace: spatial
id: BSPO:0000016

Axiom
annotated source: dorsal-ventral axis
annotated property: definition
annotated target: An axis that is approximately perpendicular to the anterior-posterior axis and that extends through the horizontal plane of the body.
database_cross_reference: BSPO:curators

Axiom
annotated source: dorsal-ventral axis
annotated property: has_narrow_synonym
annotated target: anterior-posterior axis
has_synonym_type: synonym typically used in the context of human anatomy

left-right axis
type: Class
equivalent class: Class
  intersection of: anatomical axis
  intersection of: Restriction
    on property: orthogonal to
    some values from: sagittal plane
subclass of: anatomical axis
subclass of: Restriction
  on property: orthogonal to
  some values from: sagittal plane
definition: An axis that bisects an organism from left to right sides of body, through a sagittal plane.
has_exact_synonym: L-R axis
has_exact_synonym: LR axis
has_exact_synonym: R-L axis
has_exact_synonym: RL axis
has_exact_synonym: dextro-sinister axis
has_exact_synonym: left to right axis
has_exact_synonym: right to left axis
has_exact_synonym: right-left axis
has_obo_namespace: spatial
id: BSPO:0000017

Axiom
annotated source: left-right axis
annotated property: definition
annotated target: An axis that bisects an organism from left to right sides of body, through a sagittal plane.
database_cross_reference: BSPO:cjm

transverse plane
type: Class
subclass of: anatomical plane
definition: Anatomical plane that divides body into anterior and posterior parts.
database_cross_reference: FMA:12247
has_exact_synonym: axial plane
has_exact_synonym: axial section
has_exact_synonym: transverse section
has_obo_namespace: spatial
has_related_synonym: cross-section
id: BSPO:0000018

Axiom
annotated source: transverse plane
annotated property: definition
annotated target: Anatomical plane that divides body into anterior and posterior parts.
database_cross_reference: BSPO:mah

horizontal plane
type: Class
subclass of: anatomical plane
definition: Anatomical plane that divides bilateral body into dorsal and ventral parts.
database_cross_reference: FMA:52810
has_exact_synonym: frontal plane
has_exact_synonym: horizontal anatomical plane
has_exact_synonym: horizontal section
has_obo_namespace: spatial
has_related_synonym: coronal section
has_related_synonym: frontal section
id: BSPO:0000019

Axiom
annotated source: horizontal plane
annotated property: definition
annotated target: Anatomical plane that divides bilateral body into dorsal and ventral parts.
database_cross_reference: BSPO:mah

Axiom
annotated source: horizontal plane
annotated property: has_exact_synonym
annotated target: horizontal anatomical plane
database_cross_reference: FMA:52810

antero-dorsal region
type: Class
equivalent class: Class
  intersection of: anatomical region
  intersection of: Restriction
    on property: overlaps
    some values from: anterior side
  intersection of: Restriction
    on property: overlaps
    some values from: dorsal side
subclass of: antero-ventral region
subclass of: postero-dorsal region
definition: Anatomical region that overlaps the anterior and dorsal regions of a body or body part.
created by: Melissa Haendel
creation date: 2009-06-15T01:01:38Z
has_exact_synonym: anterodorsal region
has_obo_namespace: spatial
id: BSPO:0000026

Axiom
annotated source: antero-dorsal region
annotated property: definition
annotated target: Anatomical region that overlaps the anterior and dorsal regions of a body or body part.
database_cross_reference: BSPO:wd

antero-ventral region
type: Class
equivalent class: Class
  intersection of: anatomical region
  intersection of: Restriction
    on property: overlaps
    some values from: anterior side
  intersection of: Restriction
    on property: overlaps
    some values from: ventral side
subclass of: postero-ventral region
subclass of: anterior region
definition: Anatomical region that overlaps the anterior and ventral regions of a body or body part.
created by: Melissa Haendel
creation date: 2009-06-15T01:04:59Z
has_exact_synonym: anteroventral region
has_obo_namespace: spatial
id: BSPO:0000027

Axiom
annotated source: antero-ventral region
annotated property: definition
annotated target: Anatomical region that overlaps the anterior and ventral regions of a body or body part.
database_cross_reference: BSPO:wd

postero-lateral region
type: Class
equivalent class: Class
  intersection of: anatomical region
  intersection of: Restriction
    on property: overlaps
    some values from: posterior side
  intersection of: Restriction
    on property: overlaps
    some values from: lateral side
subclass of: posterior region
subclass of: lateral region
definition: Anatomical region that overlaps the posterior and lateral regions of the body or body part.
created by: Melissa Haendel
creation date: 2009-06-15T01:06:01Z
has_exact_synonym: posterolateral region
has_obo_namespace: spatial
id: BSPO:0000028

Axiom
annotated source: postero-lateral region
annotated property: definition
annotated target: Anatomical region that overlaps the posterior and lateral regions of the body or body part.
database_cross_reference: BSPO:wd

antero-lateral region
type: Class
equivalent class: Class
  intersection of: anatomical region
  intersection of: Restriction
    on property: overlaps
    some values from: anterior side
  intersection of: Restriction
    on property: overlaps
    some values from: lateral side
subclass of: postero-lateral region
subclass of: anterior region
definition: Anatomical region that overlaps the anterior and lateral regions of a body or body part.
created by: Melissa Haendel
creation date: 2009-06-15T01:07:18Z
has_exact_synonym: anterolateral region
has_obo_namespace: spatial
id: BSPO:0000029

Axiom
annotated source: antero-lateral region
annotated property: definition
annotated target: Anatomical region that overlaps the anterior and lateral regions of a body or body part.
database_cross_reference: BSPO:wd

postero-dorsal region
type: Class
equivalent class: Class
  intersection of: anatomical region
  intersection of: Restriction
    on property: overlaps
    some values from: posterior side
  intersection of: Restriction
    on property: overlaps
    some values from: dorsal side
subclass of: postero-ventral region
subclass of: dorsal region
definition: Anatomical region that overlaps the posterior and dorsal regions of the body or body part.
created by: Melissa Haendel
creation date: 2009-06-15T01:08:13Z
has_exact_synonym: posterodorsal region
has_obo_namespace: spatial
id: BSPO:0000030

Axiom
annotated source: postero-dorsal region
annotated property: definition
annotated target: Anatomical region that overlaps the posterior and dorsal regions of the body or body part.
database_cross_reference: BSPO:wd

postero-ventral region
type: Class
equivalent class: Class
  intersection of: anatomical region
  intersection of: Restriction
    on property: overlaps
    some values from: posterior side
  intersection of: Restriction
    on property: overlaps
    some values from: ventral side
subclass of: posterior region
subclass of: ventral region
definition: Anatomical region that overlaps the posterior and ventral regions of a body or body part.
created by: Melissa Haendel
creation date: 2009-06-15T01:08:38Z
has_exact_synonym: posteroventral region
has_obo_namespace: spatial
id: BSPO:0000035

Axiom
annotated source: postero-ventral region
annotated property: definition
annotated target: Anatomical region that overlaps the posterior and ventral regions of a body or body part.
database_cross_reference: BSPO:wd

anatomical side
type: Class
subclass of: anatomical region
definition: An anatomical region bounded by a plane perpendicular to an axis through the middle.
database_cross_reference: FBql:00005841
has_obo_namespace: spatial
id: BSPO:0000054

Axiom
annotated source: anatomical side
annotated property: definition
annotated target: An anatomical region bounded by a plane perpendicular to an axis through the middle.
database_cross_reference: BSPO:cjm

anterior side
type: Class
subclass of: anatomical side
subclass of: posterior region
subclass of: Restriction
  on property: anterior to
  some values from: posterior side
subclass of: Restriction
  on property: opposite to
  some values from: posterior side
subclass of: Restriction
  on property: starts axis
  some values from: anterior-posterior axis
definition: An anatomical region that is the entire part of an anatomical structure anterior to a transverse plane and bounded on one side by the same transverse plane.
database_cross_reference: FBcv:0000053
database_cross_reference: FBql:00005848
has_exact_synonym: anterior
has_exact_synonym: rostral
has_obo_namespace: spatial
id: BSPO:0000055

Axiom
annotated source: anterior side
annotated property: definition
annotated target: An anatomical region that is the entire part of an anatomical structure anterior to a transverse plane and bounded on one side by the same transverse plane.
database_cross_reference: BSPO:RW

posterior side
type: Class
subclass of: anatomical side
subclass of: Restriction
  on property: posterior to
  some values from: anterior side
subclass of: Restriction
  on property: finishes axis
  some values from: anterior-posterior axis
definition: An anatomical region that is the entire part of an anatomical structure posterior to a transverse plane and bounded on one side by the same transverse plane.
database_cross_reference: FBcv:0000065
database_cross_reference: FBql:00005849
has_exact_synonym: posterior
has_narrow_synonym: caudal
has_obo_namespace: spatial
id: BSPO:0000056

Axiom
annotated source: posterior side
annotated property: definition
annotated target: An anatomical region that is the entire part of an anatomical structure posterior to a transverse plane and bounded on one side by the same transverse plane.
database_cross_reference: BSPO:RW
database_cross_reference: BSPO:wd

Axiom
annotated source: posterior side
annotated property: has_narrow_synonym
annotated target: caudal
has_synonym_type: synonym typically used in the context of vertebrate anatomy

apical side
type: Class
subclass of: anatomical side
subclass of: basal region
subclass of: Restriction
  on property: opposite to
  some values from: basal side
subclass of: Restriction
  on property: starts axis
  some values from: apical-basal axis relative to substrate
definition: Anatomical side that is located on the apical end of an organism or structure.
database_cross_reference: FBcv:0000054
database_cross_reference: FBql:00005854
has_exact_synonym: apical
has_obo_namespace: spatial
id: BSPO:0000057

Axiom
annotated source: apical side
annotated property: definition
annotated target: Anatomical side that is located on the apical end of an organism or structure.
database_cross_reference: BSPO:wd

basal side
type: Class
subclass of: anatomical side
subclass of: Restriction
  on property: finishes axis
  some values from: apical-basal axis relative to substrate
definition: Anatomical side that is located on the basal end of an organism or structure.
database_cross_reference: FBcv:0000055
database_cross_reference: FBql:00005855
has_exact_synonym: basal
has_obo_namespace: spatial
id: BSPO:0000058
comment: The part of the organism attached to a substrate. Axis of symmetry.

Axiom
annotated source: basal side
annotated property: definition
annotated target: Anatomical side that is located on the basal end of an organism or structure.
database_cross_reference: BSPO:wd

dorsal side
type: Class
subclass of: anatomical side
subclass of: ventral region
subclass of: Restriction
  on property: dorsal to
  some values from: lateral side
subclass of: Restriction
  on property: opposite to
  some values from: ventral side
subclass of: Restriction
  on property: starts axis
  some values from: dorsal-ventral axis
definition: An anatomical region that is the entire part of an anatomical structure dorsal to a horizontal plane and bounded on one side by the same transverse plane.
database_cross_reference: FBcv:0000059
database_cross_reference: FBql:00005842
has_exact_synonym: dorsal
has_obo_namespace: spatial
id: BSPO:0000063

Axiom
annotated source: dorsal side
annotated property: definition
annotated target: An anatomical region that is the entire part of an anatomical structure dorsal to a horizontal plane and bounded on one side by the same transverse plane.
database_cross_reference: BSPO:wd

lateral side
type: Class
subclass of: anatomical side
database_cross_reference: FBcv:0000063
database_cross_reference: FBql:00005844
has_exact_synonym: lateral
has_obo_namespace: spatial
id: BSPO:0000066

ventral side
type: Class
subclass of: anatomical side
subclass of: Restriction
  on property: finishes axis
  some values from: dorsal-ventral axis
definition: An anatomical region that is the entire part of an anatomical structure ventral to a horizontal plane and bounded on one side by the same horizontal plane.
database_cross_reference: FBcv:0000070
database_cross_reference: FBql:00005843
has_exact_synonym: ventral
has_obo_namespace: spatial
id: BSPO:0000068

Axiom
annotated source: ventral side
annotated property: definition
annotated target: An anatomical region that is the entire part of an anatomical structure ventral to a horizontal plane and bounded on one side by the same horizontal plane.
database_cross_reference: BSPO:RW
database_cross_reference: BSPO:wd

anatomical region
type: Class
subclass of: anatomical structure
definition: A 3D region in space without well-defined compartmental boundaries; for example, the dorsal region of an ectoderm.
database_cross_reference: FBql:00005841
has_obo_namespace: spatial
id: BSPO:0000070
comment: to be merged into CARO

Axiom
annotated source: anatomical region
annotated property: definition
annotated target: A 3D region in space without well-defined compartmental boundaries; for example, the dorsal region of an ectoderm.
database_cross_reference: BSPO:cjm

anterior region
type: Class
equivalent class: Class
  intersection of: anatomical region
  intersection of: Restriction
    on property: overlaps
    some values from: anterior side
subclass of: posterior region
subclass of: Restriction
  on property: overlaps
  some values from: anterior side
definition: Anatomical region anteriorly located on the body or body part.
database_cross_reference: FBql:00005848
has_obo_namespace: spatial
id: BSPO:0000071

Axiom
annotated source: anterior region
annotated property: definition
annotated target: Anatomical region anteriorly located on the body or body part.
database_cross_reference: BSPO:wd

posterior region
type: Class
equivalent class: Class
  intersection of: anatomical region
  intersection of: Restriction
    on property: overlaps
    some values from: posterior side
subclass of: anatomical region
subclass of: Restriction
  on property: overlaps
  some values from: posterior side
definition: Anatomical region posteriorly located on the body or body part.
database_cross_reference: FBql:00005849
has_obo_namespace: spatial
id: BSPO:0000072

Axiom
annotated source: posterior region
annotated property: definition
annotated target: Anatomical region posteriorly located on the body or body part.
database_cross_reference: BSPO:wd

apical region
type: Class
equivalent class: Class
  intersection of: anatomical region
  intersection of: Restriction
    on property: overlaps
    some values from: apical side
subclass of: basal region
subclass of: Restriction
  on property: overlaps
  some values from: apical side
definition: Anatomical region located on the apical end on the body or body part.
database_cross_reference: FBql:00005854
has_obo_namespace: spatial
id: BSPO:0000073

Axiom
annotated source: apical region
annotated property: definition
annotated target: Anatomical region located on the apical end on the body or body part.
database_cross_reference: BSPO:wd

basal region
type: Class
equivalent class: Class
  intersection of: anatomical region
  intersection of: Restriction
    on property: overlaps
    some values from: basal side
subclass of: anatomical region
subclass of: Restriction
  on property: overlaps
  some values from: basal side
definition: Anatomical region located basally on the body or body part.
database_cross_reference: FBql:00005855
has_obo_namespace: spatial
id: BSPO:0000074

Axiom
annotated source: basal region
annotated property: definition
annotated target: Anatomical region located basally on the body or body part.
database_cross_reference: BSPO:wd

dorsal region
type: Class
equivalent class: Class
  intersection of: anatomical region
  intersection of: Restriction
    on property: overlaps
    some values from: dorsal side
subclass of: ventral region
subclass of: Restriction
  on property: overlaps
  some values from: dorsal side
definition: Anatomical region dorsally located on the body or body part.
database_cross_reference: FBql:00005842
has_obo_namespace: spatial
id: BSPO:0000079

Axiom
annotated source: dorsal region
annotated property: definition
annotated target: Anatomical region dorsally located on the body or body part.
database_cross_reference: BSPO:wd

dorso-lateral region
type: Class
equivalent class: Class
  intersection of: anatomical region
  intersection of: Restriction
    on property: overlaps
    some values from: dorsal side
  intersection of: Restriction
    on property: overlaps
    some values from: lateral side
subclass of: dorsal region
subclass of: ventro-lateral region
definition: Anatomical region that overlaps the dorsal and lateral regions of a body or body part.
database_cross_reference: FBql:00005845
has_exact_synonym: dorsolateral region
has_obo_namespace: spatial
id: BSPO:0000080

Axiom
annotated source: dorso-lateral region
annotated property: definition
annotated target: Anatomical region that overlaps the dorsal and lateral regions of a body or body part.
database_cross_reference: BSPO:wd

lateral region
type: Class
equivalent class: Class
  intersection of: anatomical region
  intersection of: Restriction
    on property: overlaps
    some values from: lateral side
subclass of: anatomical region
subclass of: Restriction
  on property: overlaps
  some values from: lateral side
definition: Anatomical region laterally located on the body or body part.
database_cross_reference: FBql:00005844
has_obo_namespace: spatial
id: BSPO:0000082

Axiom
annotated source: lateral region
annotated property: definition
annotated target: Anatomical region laterally located on the body or body part.
database_cross_reference: BSPO:wd

ventral region
type: Class
equivalent class: Class
  intersection of: anatomical region
  intersection of: Restriction
    on property: overlaps
    some values from: ventral side
subclass of: anatomical region
subclass of: Restriction
  on property: overlaps
  some values from: ventral side
definition: Anatomical region ventrally located on the body or body part.
database_cross_reference: FBql:00005843
has_obo_namespace: spatial
id: BSPO:0000084

Axiom
annotated source: ventral region
annotated property: definition
annotated target: Anatomical region ventrally located on the body or body part.
database_cross_reference: BSPO:wd

ventro-lateral region
type: Class
equivalent class: Class
  intersection of: anatomical region
  intersection of: Restriction
    on property: overlaps
    some values from: lateral side
  intersection of: Restriction
    on property: overlaps
    some values from: ventral side
subclass of: lateral region
subclass of: ventral region
definition: Anatomical region that overlaps the ventral and lateral regions of a body or body part.
database_cross_reference: FBql:00005846
has_exact_synonym: ventrolateral region
has_obo_namespace: spatial
id: BSPO:0000085
comment: This is an example of a composition of two axis positions.

Axiom
annotated source: ventro-lateral region
annotated property: definition
annotated target: Anatomical region that overlaps the ventral and lateral regions of a body or body part.
database_cross_reference: BSPO:wd

anatomical compartment
type: Class
subclass of: anatomical structure
database_cross_reference: FBql:00005873
database_cross_reference: FMA:9647
has_obo_namespace: spatial
id: BSPO:0000086
comment: to be merged into CARO

posterior compartment
type: Class
subclass of: anatomical compartment
database_cross_reference: FBcv:0000036
database_cross_reference: FBql:00005875
has_obo_namespace: spatial
id: BSPO:0000090

anatomical compartment boundary
type: Class
subclass of: anatomical boundary
database_cross_reference: FBql:00005881
has_obo_namespace: spatial
id: BSPO:0000092
comment: to be merged into CARO

dorsal/ventral compartment boundary
type: Class
subclass of: anatomical compartment boundary
database_cross_reference: FBcv:0000034
database_cross_reference: FBql:00005879
has_obo_namespace: spatial
id: BSPO:0000094

medial-external axis
type: Class
subclass of: anatomical axis
definition: An anatomical axis that extends from the center of the body outwards or externally.
created by: wasila.dahdul
creation date: 2013-07-02T11:21:42Z
has_obo_namespace: spatial
has_related_synonym: proximal-distal axis
id: BSPO:0000196
comment: The medial-external axis could apply to a sphere-shaped body.

Axiom
annotated source: medial-external axis
annotated property: definition
annotated target: An anatomical axis that extends from the center of the body outwards or externally.
database_cross_reference: BSPO:curators

oral-aboral axis
type: Class
subclass of: anatomical axis
definition: An axis that extends from the oral opening to the furthest point in an organism that is directly opposite.
created by: wasila.dahdul
creation date: 2013-07-02T11:29:33Z
has_obo_namespace: spatial
id: BSPO:0000198

Axiom
annotated source: oral-aboral axis
annotated property: definition
annotated target: An axis that extends from the oral opening to the furthest point in an organism that is directly opposite.
database_cross_reference: BSPO:PM

anterior surface
type: Class
equivalent class: Class
  intersection of: anatomical surface
  intersection of: Restriction
    on property: surface of
    some values from: anterior side
subclass of: anatomical surface
subclass of: Restriction
  on property: surface of
  some values from: anterior side
definition: Anatomical surface that is located on the anterior side of the body or body part.
database_cross_reference: FBql:00005848
has_obo_namespace: spatial
id: BSPO:0000371

Axiom
annotated source: anterior surface
annotated property: definition
annotated target: Anatomical surface that is located on the anterior side of the body or body part.
database_cross_reference: BSPO:wd

posterior surface
type: Class
equivalent class: Class
  intersection of: anatomical surface
  intersection of: Restriction
    on property: surface of
    some values from: posterior side
subclass of: anatomical surface
subclass of: Restriction
  on property: surface of
  some values from: posterior side
definition: Anatomical surface that is located on the posterior side of the body or body part.
database_cross_reference: FBql:00005849
has_obo_namespace: spatial
id: BSPO:0000372

Axiom
annotated source: posterior surface
annotated property: definition
annotated target: Anatomical surface that is located on the posterior side of the body or body part.
database_cross_reference: BSPO:wd

apical surface
type: Class
equivalent class: Class
  intersection of: anatomical surface
  intersection of: Restriction
    on property: surface of
    some values from: apical side
subclass of: anatomical surface
subclass of: Restriction
  on property: surface of
  some values from: apical side
definition: Anatomical surface that is located on the apical side of the body or body part.
database_cross_reference: FBql:00005854
has_obo_namespace: spatial
id: BSPO:0000373

Axiom
annotated source: apical surface
annotated property: definition
annotated target: Anatomical surface that is located on the apical side of the body or body part.
database_cross_reference: BSPO:wd

basal surface
type: Class
equivalent class: Class
  intersection of: anatomical surface
  intersection of: Restriction
    on property: surface of
    some values from: basal side
subclass of: anatomical surface
subclass of: Restriction
  on property: surface of
  some values from: basal side
definition: Anatomical surface that is located on the basal side of the body or body part.
database_cross_reference: FBql:00005855
has_obo_namespace: spatial
id: BSPO:0000374

Axiom
annotated source: basal surface
annotated property: definition
annotated target: Anatomical surface that is located on the basal side of the body or body part.
database_cross_reference: BSPO:wd

dorsal surface
type: Class
equivalent class: Class
  intersection of: anatomical surface
  intersection of: Restriction
    on property: surface of
    some values from: dorsal side
subclass of: anatomical surface
subclass of: Restriction
  on property: surface of
  some values from: dorsal side
definition: Anatomical surface that located on the dorsal side of the body or body part.
database_cross_reference: FBql:00005842
has_obo_namespace: spatial
id: BSPO:0000379

Axiom
annotated source: dorsal surface
annotated property: definition
annotated target: Anatomical surface that located on the dorsal side of the body or body part.
database_cross_reference: BSPO:wd

lateral surface
type: Class
equivalent class: Class
  intersection of: anatomical surface
  intersection of: Restriction
    on property: surface of
    some values from: lateral side
subclass of: anatomical surface
subclass of: Restriction
  on property: surface of
  some values from: lateral side
definition: Anatomical surface that located on the lateral side of the body or body part.
database_cross_reference: FBql:00005844
has_obo_namespace: spatial
id: BSPO:0000382

Axiom
annotated source: lateral surface
annotated property: definition
annotated target: Anatomical surface that located on the lateral side of the body or body part.
database_cross_reference: BSPO:wd

ventral surface
type: Class
equivalent class: Class
  intersection of: anatomical surface
  intersection of: Restriction
    on property: surface of
    some values from: ventral side
subclass of: anatomical surface
subclass of: Restriction
  on property: surface of
  some values from: ventral side
definition: Anatomical surface that is located on the ventral side of the body or body part.
database_cross_reference: FBql:00005843
has_obo_namespace: spatial
id: BSPO:0000384

Axiom
annotated source: ventral surface
annotated property: definition
annotated target: Anatomical surface that is located on the ventral side of the body or body part.
database_cross_reference: BSPO:wd

anatomical plane
type: Class
subclass of: anatomical boundary
definition: A flat 2D plane intersecting an anatomical continuant, dividing it into two adjacent portions.
database_cross_reference: FMA:242982
has_exact_synonym: anatomical cross-section
has_exact_synonym: anatomical section
has_exact_synonym: plane
has_exact_synonym: section
has_obo_namespace: spatial
has_related_synonym: cross-section
id: BSPO:0000400
comment: These anatomical sections are applicable to most bilaterally symmetrical animals, but bipedal animals such as humans have more complex usage of these terms. For example, in post-embryonic humans a coronal plane is vertical and a transverse plane is horizontal, but for embryos and quadrupeds a coronal plane is horizontal and a transverse plane is vertical.

Axiom
annotated source: anatomical plane
annotated property: definition
annotated target: A flat 2D plane intersecting an anatomical continuant, dividing it into two adjacent portions.
database_cross_reference: BSPO:cjm

sagittal plane
type: Class
equivalent class: Class
  intersection of: anatomical plane
  intersection of: Restriction
    on property: orthogonal to
    some values from: left-right axis
  intersection of: Restriction
    on property: parallel to
    some values from: anterior-posterior axis
  intersection of: Restriction
    on property: parallel to
    some values from: dorsal-ventral axis
subclass of: anatomical axis
subclass of: anatomical plane
subclass of: Restriction
  on property: orthogonal to
  some values from: left-right axis
subclass of: Restriction
  on property: parallel to
  some values from: anterior-posterior axis
subclass of: Restriction
  on property: parallel to
  some values from: dorsal-ventral axis
definition: Anatomical plane that divides a bilateral body into left and right parts, not necessarily of even size.
database_cross_reference: FMA:11361
has_exact_synonym: left/right plane
has_exact_synonym: median plane
has_exact_synonym: sagittal section
has_obo_namespace: spatial
id: BSPO:0000417

Axiom
annotated source: sagittal plane
annotated property: definition
annotated target: Anatomical plane that divides a bilateral body into left and right parts, not necessarily of even size.
database_cross_reference: BSPO:DOS
database_cross_reference: BSPO:cjm
database_cross_reference: BSPO:mah

medial-lateral axis
type: Class
subclass of: medial-external axis
definition: An axis that extends from the center of organism to one or other side.
has_exact_synonym: M-L axis
has_exact_synonym: ML axis
has_exact_synonym: medio-lateral axis
has_exact_synonym: mediolateral axis
has_obo_namespace: spatial
has_related_synonym: proximal-distal axis
id: BSPO:0001001
comment: Properly, the ML axis is a half axis; practically, its usage is less clumsy and less linguistically biased than "left-right". The terms may still be used relatively to describe locations along the LR axis. The gills are medial to the operculum, but lateral to the heart.

Axiom
annotated source: medial-lateral axis
annotated property: definition
annotated target: An axis that extends from the center of organism to one or other side.
database_cross_reference: BSPO:cjm

anatomical entity
type: Class
subclass of: biological entity
definition: Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species.
imported from: caro.owl
has_obo_namespace: spatial
id: CARO:0000000

Axiom
annotated source: anatomical entity
annotated property: definition
annotated target: Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species.
database_cross_reference: CARO:MAH

anatomical structure
type: Class
subclass of: material anatomical entity
definition: Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome.
imported from: caro.owl
has_obo_namespace: spatial
id: CARO:0000003
label: connected anatomical structure

Axiom
annotated source: anatomical structure
annotated property: definition
annotated target: Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome.
database_cross_reference: CC:DOS

material anatomical entity
type: Class
subclass of: material entity
subclass of: anatomical entity
definition: An anatomical entity that has mass.
imported from: caro.owl
has_obo_namespace: spatial
id: CARO:0000006

Axiom
annotated source: material anatomical entity
annotated property: definition
annotated target: An anatomical entity that has mass.
database_cross_reference: CC:DOS

immaterial anatomical entity
type: Class
subclass of: immaterial entity
subclass of: anatomical entity
definition: An anatomical entity that has no mass.
has_obo_namespace: spatial
id: CARO:0000007

Axiom
annotated source: immaterial anatomical entity
annotated property: definition
annotated target: An anatomical entity that has no mass.
database_cross_reference: CC:DOS

anatomical line
type: Class
subclass of: immaterial anatomical entity
definition: A one dimensional, immaterial anatomical entity.
has_obo_namespace: spatial
id: CARO:0000008

Axiom
annotated source: anatomical line
annotated property: definition
annotated target: A one dimensional, immaterial anatomical entity.
database_cross_reference: CC:DOS

anatomical boundary
type: Class
subclass of: immaterial anatomical entity
definition: A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures.
has_obo_namespace: spatial
id: CARO:0000010

Axiom
annotated source: anatomical boundary
annotated property: definition
annotated target: A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures.
database_cross_reference: CC:DOS

cell part
type: Class
subclass of: anatomical structure
imported from: caro.owl
OBO foundry unique label: cell part (CARO)

organism or virus or viroid
type: Class
subclass of: material entity

multicellular anatomical structure
type: Class
subclass of: anatomical structure
subclass of: Restriction
  on property: directly develops from
  all values from: multicellular anatomical structure
imported from: caro.owl

biological entity
type: Class
subclass of: independent continuant

cell
type: Class
subclass of: anatomical structure
subclass of: Restriction
  on property: directly develops from
  all values from: cell
imported from: cl.owl

neuron
type: Class
subclass of: cell
imported from: cl.owl

environmental system
type: Class
subclass of: RO_0002577

mitochondrial genome maintenance
type: Class
subclass of: mitochondrion organization
definition: The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.
has_obo_namespace: biological_process
id: GO:0000002

Axiom
annotated source: mitochondrial genome maintenance
annotated property: definition
annotated target: The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.
database_cross_reference: GOC:ai
database_cross_reference: GOC:vw

reproduction
type: Class
subclass of: biological_process
disjoint with: biological phase
definition: The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms.
has_alternative_id: GO:0019952
has_alternative_id: GO:0050876
database_cross_reference: Wikipedia:Reproduction
has_exact_synonym: reproductive physiological process
has_obo_namespace: biological_process
id: GO:0000003
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant

Axiom
annotated source: reproduction
annotated property: definition
annotated target: The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732

mitotic spindle elongation
type: Class
equivalent class: Class
  intersection of: GO_0051231
  intersection of: Restriction
    on property: part of
    some values from: mitotic cell cycle
subclass of: GO_0051231
subclass of: GO_1903047
subclass of: Restriction
  on property: part of
  some values from: mitotic sister chromatid segregation
subclass of: Restriction
  on property: part of
  some values from: mitotic spindle organization
definition: The cell cycle process in which the distance is lengthened between poles of the mitotic spindle. Mitotic spindle elongation begins during mitotic prophase and ends during mitotic anaphase B.
has_exact_synonym: spindle elongation during mitosis
has_obo_namespace: biological_process
id: GO:0000022

Axiom
annotated source: mitotic spindle elongation
annotated property: definition
annotated target: The cell cycle process in which the distance is lengthened between poles of the mitotic spindle. Mitotic spindle elongation begins during mitotic prophase and ends during mitotic anaphase B.
database_cross_reference: GOC:mtg_cell_cycle
database_cross_reference: GOC:vw

autophagosome assembly
type: Class
subclass of: GO_0070925
subclass of: GO_1905037
subclass of: Restriction
  on property: has part
  some values from: Atg12 activating enzyme activity
subclass of: Restriction
  on property: has part
  some values from: Atg8-specific protease activity
subclass of: Restriction
  on property: has part
  some values from: GO_0061651
subclass of: Restriction
  on property: has part
  some values from: GO_0061660
definition: The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.
has_exact_synonym: autophagic vacuole assembly
has_exact_synonym: autophagosome biosynthesis
has_exact_synonym: autophagosome formation
has_narrow_synonym: PAS formation
has_obo_namespace: biological_process
has_related_synonym: autophagic vacuole formation
id: GO:0000045

Axiom
annotated source: autophagosome assembly
annotated property: definition
annotated target: The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.
database_cross_reference: GOC:autophagy
database_cross_reference: PMID:9412464

Axiom
annotated source: autophagosome assembly
annotated property: has_exact_synonym
annotated target: autophagic vacuole assembly
database_cross_reference: GOC:autophagy

Axiom
annotated source: autophagosome assembly
annotated property: has_related_synonym
annotated target: autophagic vacuole formation
database_cross_reference: GOC:mah

mitotic sister chromatid segregation
type: Class
equivalent class: Class
  intersection of: GO_0098813
  intersection of: Restriction
    on property: part of
    some values from: GO_0140014
subclass of: sister chromatid segregation
subclass of: GO_1903047
subclass of: Restriction
  on property: part of
  some values from: GO_0140014
definition: The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
has_alternative_id: GO:0016359
has_exact_synonym: mitotic chromosome segregation
has_narrow_synonym: mitotic sister-chromatid adhesion release
has_obo_namespace: biological_process
id: GO:0000070
in_subset: goslim pombe

Axiom
annotated source: mitotic sister chromatid segregation
annotated property: definition
annotated target: The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
database_cross_reference: GOC:ai
database_cross_reference: GOC:jl

mitotic G1 phase
type: Class
subclass of: GO_0051318
subclass of: Restriction
  on property: part of
  some values from: GO_0051329
definition: The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis.
database_cross_reference: MIPS_funcat:10.03.01.01.01
has_exact_synonym: G1 phase of mitotic cell cycle
has_obo_namespace: biological_process
id: GO:0000080
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: mitotic G1 phase
annotated property: definition
annotated target: The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis.
database_cross_reference: GOC:mtg_cell_cycle

mitotic S phase
type: Class
subclass of: GO_0051320
subclass of: Restriction
  on property: part of
  some values from: GO_0051329
definition: The cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle.
database_cross_reference: MIPS_funcat:10.03.01.01.05
has_exact_synonym: S phase of mitotic cell cycle
has_exact_synonym: S-phase of mitotic cell cycle
has_obo_namespace: biological_process
id: GO:0000084
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: mitotic S phase
annotated property: definition
annotated target: The cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle.
database_cross_reference: GOC:mtg_cell_cycle

mitotic G2 phase
type: Class
subclass of: GO_0051319
subclass of: Restriction
  on property: part of
  some values from: GO_0051329
definition: The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by mitosis.
database_cross_reference: MIPS_funcat:10.03.01.01.07
has_exact_synonym: G2 phase of mitotic cell cycle
has_obo_namespace: biological_process
id: GO:0000085
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: mitotic G2 phase
annotated property: definition
annotated target: The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by mitosis.
database_cross_reference: GOC:mtg_cell_cycle

mitotic M phase
type: Class
equivalent class: Class
  intersection of: M phase
  intersection of: Restriction
    on property: happens during
    some values from: mitotic cell cycle
subclass of: M phase
subclass of: GO_0098763
definition: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle.
has_exact_synonym: M phase of mitotic cell cycle
has_exact_synonym: M-phase of mitotic cell cycle
has_obo_namespace: biological_process
id: GO:0000087
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: mitotic M phase
annotated property: definition
annotated target: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle.
database_cross_reference: GOC:mtg_cell_cycle

mitotic prophase
type: Class
subclass of: GO_0051324
subclass of: Restriction
  on property: part of
  some values from: mitotic M phase
definition: The cell cycle phase which is the first stage of M phase of mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.
has_obo_namespace: biological_process
id: GO:0000088
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: mitotic prophase
annotated property: definition
annotated target: The cell cycle phase which is the first stage of M phase of mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.
database_cross_reference: GOC:mtg_cell_cycle

mitotic metaphase
type: Class
subclass of: GO_0051323
subclass of: Restriction
  on property: part of
  some values from: mitotic M phase
definition: The cell cycle phase, following prophase, during which chromosomes become aligned on the equatorial plate of the cell as part of a mitotic cell cycle.
has_obo_namespace: biological_process
id: GO:0000089
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: mitotic metaphase
annotated property: definition
annotated target: The cell cycle phase, following prophase, during which chromosomes become aligned on the equatorial plate of the cell as part of a mitotic cell cycle.
database_cross_reference: GOC:mtg_cell_cycle

mitotic anaphase
type: Class
subclass of: GO_0051322
subclass of: Restriction
  on property: part of
  some values from: mitotic M phase
definition: The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of a mitotic cell cycle.
has_obo_namespace: biological_process
id: GO:0000090
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: mitotic anaphase
annotated property: definition
annotated target: The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of a mitotic cell cycle.
database_cross_reference: GOC:mtg_cell_cycle

mitotic telophase
type: Class
subclass of: GO_0051326
subclass of: Restriction
  on property: part of
  some values from: mitotic M phase
definition: The cell cycle phase which follows anaphase during M phase of mitosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts.
has_obo_namespace: biological_process
id: GO:0000093
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: mitotic telophase
annotated property: definition
annotated target: The cell cycle phase which follows anaphase during M phase of mitosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts.
database_cross_reference: GOC:mtg_cell_cycle

negative regulation of transcription by RNA polymerase II
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: transcription by RNA polymerase II
subclass of: regulation of transcription by RNA polymerase II
subclass of: negative regulation of transcription, DNA-templated
subclass of: Restriction
  on property: negatively regulates
  some values from: transcription by RNA polymerase II
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
has_alternative_id: GO:0010553
has_alternative_id: GO:0045816
has_exact_synonym: down regulation of transcription from RNA polymerase II promoter
has_exact_synonym: down-regulation of transcription from RNA polymerase II promoter
has_exact_synonym: downregulation of transcription from RNA polymerase II promoter
has_exact_synonym: inhibition of transcription from RNA polymerase II promoter
has_exact_synonym: negative regulation of transcription from Pol II promoter
has_exact_synonym: negative regulation of transcription from RNA polymerase II promoter
has_obo_namespace: biological_process
has_related_synonym: down regulation of global transcription from RNA polymerase II promoter
has_related_synonym: down-regulation of global transcription from RNA polymerase II promoter
has_related_synonym: downregulation of global transcription from RNA polymerase II promoter
has_related_synonym: inhibition of global transcription from RNA polymerase II promoter
has_related_synonym: negative regulation of gene-specific transcription from RNA polymerase II promoter
has_related_synonym: negative regulation of global transcription from Pol II promoter
has_related_synonym: negative regulation of transcription from RNA polymerase II promoter, global
id: GO:0000122

Axiom
annotated source: negative regulation of transcription by RNA polymerase II
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:txnOH

meiotic spindle organization
type: Class
equivalent class: Class
  intersection of: spindle organization
  intersection of: Restriction
    on property: part of
    some values from: GO_0051321
subclass of: spindle organization
subclass of: GO_1903046
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle.
has_alternative_id: GO:0043147
has_exact_synonym: meiotic spindle organisation
has_exact_synonym: spindle organization during meiosis
has_obo_namespace: biological_process
has_related_synonym: meiotic spindle organization and biogenesis
has_related_synonym: meiotic spindle stabilization
id: GO:0000212

Axiom
annotated source: meiotic spindle organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:mah

Axiom
annotated source: meiotic spindle organization
annotated property: has_exact_synonym
annotated target: spindle organization during meiosis
database_cross_reference: GOC:mah

Axiom
annotated source: meiotic spindle organization
annotated property: has_related_synonym
annotated target: meiotic spindle organization and biogenesis
database_cross_reference: GOC:mah

microtubule cytoskeleton organization
type: Class
subclass of: cytoskeleton organization
subclass of: microtubule-based process
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
has_exact_synonym: microtubule cytoskeleton organisation
has_exact_synonym: microtubule dynamics
has_obo_namespace: biological_process
has_related_synonym: microtubule cytoskeleton organization and biogenesis
id: GO:0000226
in_subset: goslim drosophila
in_subset: goslim pombe

Axiom
annotated source: microtubule cytoskeleton organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
database_cross_reference: GOC:mah

Axiom
annotated source: microtubule cytoskeleton organization
annotated property: has_exact_synonym
annotated target: microtubule cytoskeleton organisation
database_cross_reference: GOC:mah

Axiom
annotated source: microtubule cytoskeleton organization
annotated property: has_exact_synonym
annotated target: microtubule dynamics
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

Axiom
annotated source: microtubule cytoskeleton organization
annotated property: has_related_synonym
annotated target: microtubule cytoskeleton organization and biogenesis
database_cross_reference: GOC:mah

leptotene
type: Class
subclass of: GO_0098764
subclass of: Restriction
  on property: part of
  some values from: meiotic prophase I
definition: The cell cycle phase which is the first stage of prophase I in meiosis, and during which the chromosomes first become visible.
database_cross_reference: Wikipedia:Leptotene
database_cross_reference: Wikipedia:Meiosis#Leptotene
has_obo_namespace: biological_process
id: GO:0000237
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: leptotene
annotated property: definition
annotated target: The cell cycle phase which is the first stage of prophase I in meiosis, and during which the chromosomes first become visible.
database_cross_reference: GOC:mtg_cell_cycle

zygotene
type: Class
subclass of: GO_0098764
subclass of: Restriction
  on property: part of
  some values from: meiotic prophase I
definition: The cell cycle phase which follows leptotene during prophase I of meiosis, and during which each chromosome pairs with its homolog; the two become aligned and crossing over may occur.
database_cross_reference: Wikipedia:Meiosis#Zygotene
database_cross_reference: Wikipedia:Zygotene
has_obo_namespace: biological_process
id: GO:0000238
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: zygotene
annotated property: definition
annotated target: The cell cycle phase which follows leptotene during prophase I of meiosis, and during which each chromosome pairs with its homolog; the two become aligned and crossing over may occur.
database_cross_reference: GOC:mtg_cell_cycle

pachytene
type: Class
subclass of: GO_0098764
subclass of: Restriction
  on property: part of
  some values from: meiotic prophase I
definition: The cell cycle phase which follows zygotene during prophase I of meiosis, and during which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome.
database_cross_reference: Wikipedia:Meiosis#Pachytene
database_cross_reference: Wikipedia:Pachytene
has_obo_namespace: biological_process
id: GO:0000239
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: pachytene
annotated property: definition
annotated target: The cell cycle phase which follows zygotene during prophase I of meiosis, and during which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome.
database_cross_reference: GOC:mtg_cell_cycle

diplotene
type: Class
subclass of: GO_0098764
subclass of: Restriction
  on property: part of
  some values from: meiotic prophase I
definition: The cell cycle phase which follows pachytene during prophase I of meiosis, during which the homologous chromosomes begin to separate and the synaptonemal complex dissolves.
database_cross_reference: Wikipedia:Diplotene
database_cross_reference: Wikipedia:Meiosis#Diplotene
has_obo_namespace: biological_process
id: GO:0000240
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: diplotene
annotated property: definition
annotated target: The cell cycle phase which follows pachytene during prophase I of meiosis, during which the homologous chromosomes begin to separate and the synaptonemal complex dissolves.
database_cross_reference: GOC:mtg_cell_cycle

diakinesis
type: Class
subclass of: GO_0098764
subclass of: Restriction
  on property: part of
  some values from: meiotic prophase I
definition: The cell cycle phase which follows diplotene during prophase I of meiosis, the separation of homologous chromosomes is complete and crossing over has occurred.
database_cross_reference: Wikipedia:Diakinesis
database_cross_reference: Wikipedia:Meiosis#Diakinesis
has_obo_namespace: biological_process
id: GO:0000241
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: diakinesis
annotated property: definition
annotated target: The cell cycle phase which follows diplotene during prophase I of meiosis, the separation of homologous chromosomes is complete and crossing over has occurred.
database_cross_reference: GOC:mtg_cell_cycle

mitotic cell cycle
type: Class
equivalent class: Class
  intersection of: cell cycle
  intersection of: Restriction
    on property: has part
    some values from: GO_0140014
subclass of: cell cycle
subclass of: Restriction
  on property: has part
  some values from: GO_0140014
definition: Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
has_alternative_id: GO:0007067
database_cross_reference: MIPS_funcat:10.03.01
database_cross_reference: MIPS_funcat:10.03.01.01
database_cross_reference: Wikipedia:Mitosis
has_obo_namespace: biological_process
has_related_synonym: mitosis
id: GO:0000278
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim yeast

Axiom
annotated source: mitotic cell cycle
annotated property: definition
annotated target: Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0815316194
database_cross_reference: Reactome:69278

M phase
type: Class
subclass of: cell cycle phase
definition: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase.
database_cross_reference: Wikipedia:M_phase
has_exact_synonym: M-phase
has_obo_namespace: biological_process
id: GO:0000279
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: M phase
annotated property: definition
annotated target: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase.
database_cross_reference: GOC:mtg_cell_cycle

nuclear division
type: Class
subclass of: organelle fission
definition: The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.
database_cross_reference: MIPS_funcat:10.03.04
database_cross_reference: MIPS_funcat:10.03.04.07
has_obo_namespace: biological_process
has_related_synonym: karyokinesis
id: GO:0000280
in_subset: goslim pir

Axiom
annotated source: nuclear division
annotated property: definition
annotated target: The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.
database_cross_reference: GOC:mah

lytic vacuole
type: Class
subclass of: vacuole
definition: A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases.
has_obo_namespace: cellular_component
id: GO:0000323

Axiom
annotated source: lytic vacuole
annotated property: definition
annotated target: A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases.
database_cross_reference: GOC:krc

sister chromatid segregation
type: Class
subclass of: GO_0051276
subclass of: GO_0098813
definition: The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets.
has_obo_namespace: biological_process
id: GO:0000819

Axiom
annotated source: sister chromatid segregation
annotated property: definition
annotated target: The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets.
database_cross_reference: GOC:ai
database_cross_reference: GOC:elh

mitochondrial RNA metabolic process
type: Class
equivalent class: Class
  intersection of: RNA metabolic process
  intersection of: Restriction
    on property: occurs in
    some values from: mitochondrion
subclass of: RNA metabolic process
subclass of: Restriction
  on property: occurs in
  some values from: mitochondrion
definition: The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion.
has_obo_namespace: biological_process
id: GO:0000959

Axiom
annotated source: mitochondrial RNA metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion.
database_cross_reference: GOC:krc
database_cross_reference: GOC:mah

response to acid chemical
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.
has_broad_synonym: response to acid
has_obo_namespace: biological_process
has_related_synonym: response to acid anion
has_related_synonym: response to oxoanion
id: GO:0001101
in_subset: gocheck do not manually annotate
comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if an organism were responding to glutamate, then the response would be glutamate-specific; the organism is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0010447 'response to acidic pH' instead.

Axiom
annotated source: response to acid chemical
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:rn

retinoid metabolic process
type: Class
subclass of: diterpenoid metabolic process
definition: The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.
has_exact_synonym: retinoid metabolism
has_obo_namespace: biological_process
id: GO:0001523

Axiom
annotated source: retinoid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.
database_cross_reference: ISBN:0198506732

angiogenesis
type: Class
subclass of: anatomical structure formation involved in morphogenesis
subclass of: Restriction
  on property: part of
  some values from: blood vessel morphogenesis
definition: Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
database_cross_reference: Wikipedia:Angiogenesis
has_exact_synonym: blood vessel formation from pre-existing blood vessels
has_obo_namespace: biological_process
id: GO:0001525

Axiom
annotated source: angiogenesis
annotated property: definition
annotated target: Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
database_cross_reference: ISBN:0878932453

Axiom
annotated source: angiogenesis
annotated property: has_exact_synonym
annotated target: blood vessel formation from pre-existing blood vessels
has_synonym_type: Systematic synonym

cilium or flagellum-dependent cell motility
type: Class
subclass of: cell motility
definition: Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella.
has_exact_synonym: ciliary/flagellar motility
has_obo_namespace: biological_process
has_related_synonym: ciliary or bacterial-type flagellar motility
id: GO:0001539
in_subset: gocheck do not manually annotate
comment: Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent, while the bacterial- and archaeal-type flagella have a different structure. The former are microtubule-based structures that lash back and forth and are present only in eukaryotes, while the latter achieve motility by rotation. Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. These three structures never co-exist in the same organism. Therefore, GO:0001539 'cilium or flagellum-dependent cell motility' is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term. Direct annotations to GO:0001539 'cilium or flagellum-dependent cell motility' may be amended during annotation QC.

Axiom
annotated source: cilium or flagellum-dependent cell motility
annotated property: definition
annotated target: Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella.
database_cross_reference: GOC:cilia
database_cross_reference: GOC:hjd
database_cross_reference: GOC:krc

regulation of cell growth
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cell growth
subclass of: regulation of growth
subclass of: GO_0051128
subclass of: Restriction
  on property: regulates
  some values from: cell growth
definition: Any process that modulates the frequency, rate, extent or direction of cell growth.
has_obo_namespace: biological_process
id: GO:0001558

Axiom
annotated source: regulation of cell growth
annotated property: definition
annotated target: Any process that modulates the frequency, rate, extent or direction of cell growth.
database_cross_reference: GOC:go_curators

regulation of cell growth by extracellular stimulus
type: Class
equivalent class: Class
  intersection of: regulation of cell growth
  intersection of: Restriction
    on property: part of
    some values from: cellular response to extracellular stimulus
subclass of: regulation of cell growth
subclass of: Restriction
  on property: part of
  some values from: cellular response to extracellular stimulus
definition: Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time.
has_exact_synonym: interpretation of external signals that regulate cell growth
has_exact_synonym: regulation of cell growth by detection of exogenous stimulus
has_exact_synonym: regulation of cell growth by sensing of exogenous stimulus
has_exact_synonym: regulation of growth by exogenous signal
has_exact_synonym: regulation of growth by exogenous stimuli
has_exact_synonym: regulation of growth by exogenous stimulus
has_exact_synonym: regulation of growth by external signal
has_exact_synonym: regulation of growth by external stimuli
has_exact_synonym: regulation of growth by external stimulus
has_obo_namespace: biological_process
id: GO:0001560

Axiom
annotated source: regulation of cell growth by extracellular stimulus
annotated property: definition
annotated target: Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time.
database_cross_reference: GOC:dph

blood vessel development
type: Class
subclass of: anatomical structure development
subclass of: Restriction
  on property: part of
  some values from: vasculature development
definition: The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
has_obo_namespace: biological_process
id: GO:0001568

Axiom
annotated source: blood vessel development
annotated property: definition
annotated target: The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
database_cross_reference: GOC:hjd
database_cross_reference: UBERON:0001981

microtubule bundle formation
type: Class
subclass of: microtubule cytoskeleton organization
definition: A process that results in a parallel arrangement of microtubules.
has_exact_synonym: microtubule bundling
has_obo_namespace: biological_process
id: GO:0001578

Axiom
annotated source: microtubule bundle formation
annotated property: definition
annotated target: A process that results in a parallel arrangement of microtubules.
database_cross_reference: GOC:dph

conditioned taste aversion
type: Class
subclass of: feeding behavior
subclass of: associative learning
definition: A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus.
database_cross_reference: Wikipedia:Conditioned_taste_aversion
database_cross_reference: Wikipedia:Taste_aversion
has_obo_namespace: biological_process
id: GO:0001661

Axiom
annotated source: conditioned taste aversion
annotated property: definition
annotated target: A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus.
database_cross_reference: GOC:dph
database_cross_reference: PMID:9920659

acrosome assembly
type: Class
subclass of: developmental process involved in reproduction
subclass of: cellular component assembly involved in morphogenesis
subclass of: cellular process involved in reproduction in multicellular organism
subclass of: secretory granule organization
subclass of: GO_0070925
subclass of: Restriction
  on property: part of
  some values from: spermatid development
definition: The formation of the acrosome from the spermatid Golgi.
has_exact_synonym: acrosome formation
has_obo_namespace: biological_process
id: GO:0001675

Axiom
annotated source: acrosome assembly
annotated property: definition
annotated target: The formation of the acrosome from the spermatid Golgi.
database_cross_reference: GOC:dph
database_cross_reference: GOC:hjd
database_cross_reference: GOC:tb

Axiom
annotated source: acrosome assembly
annotated property: has_exact_synonym
annotated target: acrosome formation
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

cell activation
type: Class
subclass of: cellular process
definition: A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.
has_obo_namespace: biological_process
id: GO:0001775
in_subset: goslim pir

Axiom
annotated source: cell activation
annotated property: definition
annotated target: A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.
database_cross_reference: GOC:mgi_curators

autolysis
type: Class
subclass of: programmed cell death
definition: A programmed cell death process observed in bacteria and filamentous fungi and leading to spontaneous death by lysis. Examples are lysis of the mother cell during sporulation of Bacillus subtilis and self-degradation of fungal cells in Aspergillus nidulans. Autolysis is also involved in bacterial biofilm formation.
never in taxon: NCBITaxon_33208
database_cross_reference: Wikipedia:Autolysis
has_obo_namespace: biological_process
id: GO:0001896

Axiom
annotated source: autolysis
annotated property: definition
annotated target: A programmed cell death process observed in bacteria and filamentous fungi and leading to spontaneous death by lysis. Examples are lysis of the mother cell during sporulation of Bacillus subtilis and self-degradation of fungal cells in Aspergillus nidulans. Autolysis is also involved in bacterial biofilm formation.
database_cross_reference: GOC:add
database_cross_reference: GOC:jh2
database_cross_reference: GOC:mtg_apoptosis
database_cross_reference: PMID:10974124
database_cross_reference: PMID:19286987
database_cross_reference: PMID:26811896

cell killing
type: Class
subclass of: cellular process
disjoint with: biological phase
definition: Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.
has_obo_namespace: biological_process
has_related_synonym: necrosis
id: GO:0001906
in_subset: goslim pir

Axiom
annotated source: cell killing
annotated property: definition
annotated target: Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.
database_cross_reference: GOC:add

killing by symbiont of host cells
type: Class
subclass of: GO_0051701
subclass of: GO_0051883
definition: Any process mediated by an organism that results in the death of cells in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has_obo_namespace: biological_process
id: GO:0001907

Axiom
annotated source: killing by symbiont of host cells
annotated property: definition
annotated target: Any process mediated by an organism that results in the death of cells in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
database_cross_reference: GOC:add

regulation of protein phosphorylation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: protein phosphorylation
subclass of: regulation of protein modification process
subclass of: regulation of phosphorylation
subclass of: Restriction
  on property: regulates
  some values from: protein phosphorylation
definition: Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
has_exact_synonym: regulation of protein amino acid phosphorylation
has_obo_namespace: biological_process
id: GO:0001932

Axiom
annotated source: regulation of protein phosphorylation
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
database_cross_reference: GOC:hjd

Axiom
annotated source: regulation of protein phosphorylation
annotated property: has_exact_synonym
annotated target: regulation of protein amino acid phosphorylation
database_cross_reference: GOC:bf

negative regulation of protein phosphorylation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: protein phosphorylation
subclass of: regulation of protein phosphorylation
subclass of: negative regulation of protein modification process
subclass of: negative regulation of phosphorylation
subclass of: Restriction
  on property: negatively regulates
  some values from: protein phosphorylation
definition: Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
has_exact_synonym: down regulation of protein amino acid phosphorylation
has_exact_synonym: down-regulation of protein amino acid phosphorylation
has_exact_synonym: downregulation of protein amino acid phosphorylation
has_exact_synonym: negative regulation of protein amino acid phosphorylation
has_narrow_synonym: inhibition of protein amino acid phosphorylation
has_obo_namespace: biological_process
id: GO:0001933

Axiom
annotated source: negative regulation of protein phosphorylation
annotated property: definition
annotated target: Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
database_cross_reference: GOC:hjd

Axiom
annotated source: negative regulation of protein phosphorylation
annotated property: has_exact_synonym
annotated target: negative regulation of protein amino acid phosphorylation
database_cross_reference: GOC:bf

positive regulation of protein phosphorylation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: protein phosphorylation
subclass of: regulation of protein phosphorylation
subclass of: positive regulation of protein modification process
subclass of: positive regulation of phosphorylation
subclass of: Restriction
  on property: positively regulates
  some values from: protein phosphorylation
definition: Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
has_exact_synonym: positive regulation of protein amino acid phosphorylation
has_exact_synonym: up regulation of protein amino acid phosphorylation
has_exact_synonym: up-regulation of protein amino acid phosphorylation
has_exact_synonym: upregulation of protein amino acid phosphorylation
has_narrow_synonym: activation of protein amino acid phosphorylation
has_narrow_synonym: stimulation of protein amino acid phosphorylation
has_obo_namespace: biological_process
id: GO:0001934

Axiom
annotated source: positive regulation of protein phosphorylation
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
database_cross_reference: GOC:hjd

Axiom
annotated source: positive regulation of protein phosphorylation
annotated property: has_exact_synonym
annotated target: positive regulation of protein amino acid phosphorylation
database_cross_reference: GOC:bf

vasculature development
type: Class
subclass of: system development
subclass of: Restriction
  on property: part of
  some values from: GO_0072358
definition: The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.
has_obo_namespace: biological_process
has_related_synonym: vascular system development
id: GO:0001944

Axiom
annotated source: vasculature development
annotated property: definition
annotated target: The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.
database_cross_reference: GOC:dph
database_cross_reference: UBERON:0002409

wound healing involved in inflammatory response
type: Class
equivalent class: Class
  intersection of: wound healing
  intersection of: Restriction
    on property: part of
    some values from: inflammatory response
subclass of: wound healing
subclass of: Restriction
  on property: part of
  some values from: GO_0090594
definition: The series of events that restore integrity to damaged tissue that contribute to an inflammatory response.
has_obo_namespace: biological_process
has_related_synonym: healing during inflammatory response
has_related_synonym: inflammatory response wound healing
id: GO:0002246

Axiom
annotated source: wound healing involved in inflammatory response
annotated property: definition
annotated target: The series of events that restore integrity to damaged tissue that contribute to an inflammatory response.
database_cross_reference: GOC:jal
database_cross_reference: ISBN:0721601871

Axiom
annotated source: wound healing involved in inflammatory response
annotated property: has_related_synonym
annotated target: healing during inflammatory response
database_cross_reference: GOC:dph

Axiom
annotated source: wound healing involved in inflammatory response
annotated property: has_related_synonym
annotated target: inflammatory response wound healing
database_cross_reference: GOC:dph

adaptive immune response
type: Class
subclass of: immune response
definition: An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
database_cross_reference: Wikipedia:Adaptive_immune_system
has_exact_synonym: acquired immune response
has_exact_synonym: immune memory response
has_obo_namespace: biological_process
id: GO:0002250

Axiom
annotated source: adaptive immune response
annotated property: definition
annotated target: An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
database_cross_reference: GOC:add
database_cross_reference: GO_REF:0000022
database_cross_reference: ISBN:0781735149

Axiom
annotated source: adaptive immune response
annotated property: has_exact_synonym
annotated target: acquired immune response
database_cross_reference: ISBN:068340007X

Axiom
annotated source: adaptive immune response
annotated property: has_exact_synonym
annotated target: immune memory response
database_cross_reference: GOC:add

immune effector process
type: Class
subclass of: immune system process
definition: Any process of the immune system that can potentially contribute to an immune response.
has_obo_namespace: biological_process
id: GO:0002252

Axiom
annotated source: immune effector process
annotated property: definition
annotated target: Any process of the immune system that can potentially contribute to an immune response.
database_cross_reference: GOC:add
database_cross_reference: GO_REF:0000022
database_cross_reference: ISBN:0781735149

myeloid cell homeostasis
type: Class
subclass of: immune system process
subclass of: homeostasis of number of cells
definition: The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
has_obo_namespace: biological_process
id: GO:0002262

Axiom
annotated source: myeloid cell homeostasis
annotated property: definition
annotated target: The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
database_cross_reference: CL:0000763
database_cross_reference: GOC:add

cell activation involved in immune response
type: Class
equivalent class: Class
  intersection of: cell activation
  intersection of: Restriction
    on property: part of
    some values from: immune response
subclass of: cell activation
subclass of: immune effector process
subclass of: Restriction
  on property: part of
  some values from: immune response
definition: A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
has_obo_namespace: biological_process
has_related_synonym: cell activation during immune response
id: GO:0002263

Axiom
annotated source: cell activation involved in immune response
annotated property: definition
annotated target: A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
database_cross_reference: GOC:add
database_cross_reference: GO_REF:0000022
database_cross_reference: ISBN:0781735149

Axiom
annotated source: cell activation involved in immune response
annotated property: has_related_synonym
annotated target: cell activation during immune response
database_cross_reference: GOC:tb

leukocyte activation involved in inflammatory response
type: Class
equivalent class: Class
  intersection of: leukocyte activation
  intersection of: Restriction
    on property: part of
    some values from: inflammatory response
subclass of: leukocyte activation
subclass of: Restriction
  on property: part of
  some values from: inflammatory response
definition: A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response.
has_obo_namespace: biological_process
has_related_synonym: immune cell activation during inflammatory response
has_related_synonym: leukocyte activation during inflammatory response
id: GO:0002269

Axiom
annotated source: leukocyte activation involved in inflammatory response
annotated property: definition
annotated target: A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response.
database_cross_reference: GOC:add
database_cross_reference: ISBN:0781735149

Axiom
annotated source: leukocyte activation involved in inflammatory response
annotated property: has_related_synonym
annotated target: leukocyte activation during inflammatory response
database_cross_reference: GOC:tb

myeloid leukocyte activation
type: Class
subclass of: leukocyte activation
definition: A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand.
has_exact_synonym: myeloid leucocyte activation
has_obo_namespace: biological_process
id: GO:0002274

Axiom
annotated source: myeloid leukocyte activation
annotated property: definition
annotated target: A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand.
database_cross_reference: GOC:add
database_cross_reference: ISBN:0781735149

myeloid cell activation involved in immune response
type: Class
subclass of: myeloid leukocyte activation
subclass of: leukocyte activation involved in immune response
definition: A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
has_obo_namespace: biological_process
has_related_synonym: myeloid cell activation during immune response
id: GO:0002275

Axiom
annotated source: myeloid cell activation involved in immune response
annotated property: definition
annotated target: A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
database_cross_reference: GOC:add
database_cross_reference: ISBN:0781735149

Axiom
annotated source: myeloid cell activation involved in immune response
annotated property: has_related_synonym
annotated target: myeloid cell activation during immune response
database_cross_reference: GOC:tb

macrophage activation involved in immune response
type: Class
equivalent class: Class
  intersection of: macrophage activation
  intersection of: Restriction
    on property: part of
    some values from: immune response
subclass of: myeloid cell activation involved in immune response
subclass of: macrophage activation
definition: A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has_exact_synonym: macrophage polarization involved in immune response
has_obo_namespace: biological_process
has_related_synonym: macrophage activation during immune response
id: GO:0002281

Axiom
annotated source: macrophage activation involved in immune response
annotated property: definition
annotated target: A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
database_cross_reference: GOC:add
database_cross_reference: ISBN:0781735149

Axiom
annotated source: macrophage activation involved in immune response
annotated property: has_related_synonym
annotated target: macrophage activation during immune response
database_cross_reference: GOC:tb

lymphocyte activation involved in immune response
type: Class
equivalent class: Class
  intersection of: lymphocyte activation
  intersection of: Restriction
    on property: part of
    some values from: immune response
subclass of: leukocyte activation involved in immune response
subclass of: lymphocyte activation
definition: A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has_obo_namespace: biological_process
has_related_synonym: lymphocyte activation during immune response
id: GO:0002285

Axiom
annotated source: lymphocyte activation involved in immune response
annotated property: definition
annotated target: A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
database_cross_reference: GOC:add
database_cross_reference: ISBN:0781735149

Axiom
annotated source: lymphocyte activation involved in immune response
annotated property: has_related_synonym
annotated target: lymphocyte activation during immune response
database_cross_reference: GOC:tb

natural killer cell activation involved in immune response
type: Class
equivalent class: Class
  intersection of: natural killer cell activation
  intersection of: Restriction
    on property: part of
    some values from: immune response
subclass of: lymphocyte activation involved in immune response
subclass of: natural killer cell activation
definition: The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has_obo_namespace: biological_process
has_related_synonym: NK cell activation during immune response
has_related_synonym: natural killer cell activation during immune response
id: GO:0002323

Axiom
annotated source: natural killer cell activation involved in immune response
annotated property: definition
annotated target: The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
database_cross_reference: GOC:add
database_cross_reference: PMID:15032583

Axiom
annotated source: natural killer cell activation involved in immune response
annotated property: has_related_synonym
annotated target: natural killer cell activation during immune response
database_cross_reference: GOC:tb

leukocyte activation involved in immune response
type: Class
equivalent class: Class
  intersection of: leukocyte activation
  intersection of: Restriction
    on property: part of
    some values from: immune response
subclass of: cell activation involved in immune response
subclass of: leukocyte activation
definition: A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has_obo_namespace: biological_process
has_related_synonym: immune cell activation during immune response
has_related_synonym: leucocyte activation during immune response
has_related_synonym: leukocyte activation during immune response
id: GO:0002366

Axiom
annotated source: leukocyte activation involved in immune response
annotated property: definition
annotated target: A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
database_cross_reference: GOC:add
database_cross_reference: ISBN:0781735149

Axiom
annotated source: leukocyte activation involved in immune response
annotated property: has_related_synonym
annotated target: leukocyte activation during immune response
database_cross_reference: GOC:tb

immune system process
type: Class
subclass of: biological_process
disjoint with: biological phase
definition: Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
never in taxon: NCBITaxon 4895
database_cross_reference: Wikipedia:Immune_system
has_obo_namespace: biological_process
id: GO:0002376
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501).

Axiom
annotated source: immune system process
annotated property: definition
annotated target: Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
database_cross_reference: GOC:add
database_cross_reference: GO_REF:0000022

inflammatory response to antigenic stimulus
type: Class
subclass of: inflammatory response
subclass of: immune response
definition: An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes.
has_obo_namespace: biological_process
id: GO:0002437

Axiom
annotated source: inflammatory response to antigenic stimulus
annotated property: definition
annotated target: An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes.
database_cross_reference: GOC:add
database_cross_reference: ISBN:0781735149

acute inflammatory response to antigenic stimulus
type: Class
subclass of: inflammatory response to antigenic stimulus
subclass of: acute inflammatory response
definition: An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.
has_obo_namespace: biological_process
id: GO:0002438

Axiom
annotated source: acute inflammatory response to antigenic stimulus
annotated property: definition
annotated target: An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.
database_cross_reference: GOC:add
database_cross_reference: GO_REF:0000022
database_cross_reference: ISBN:0781735149

leukocyte mediated immunity
type: Class
subclass of: immune effector process
definition: Any process involved in the carrying out of an immune response by a leukocyte.
has_alternative_id: GO:0019723
has_alternative_id: GO:0042087
has_exact_synonym: immune cell effector process
has_exact_synonym: immune cell mediated immunity
has_exact_synonym: leucocyte immune effector process
has_exact_synonym: leucocyte mediated immunity
has_exact_synonym: leukocyte immune effector process
has_obo_namespace: biological_process
has_related_synonym: cell-mediated immune response
has_related_synonym: cellular immune response
id: GO:0002443

Axiom
annotated source: leukocyte mediated immunity
annotated property: definition
annotated target: Any process involved in the carrying out of an immune response by a leukocyte.
database_cross_reference: GOC:add
database_cross_reference: GO_REF:0000022
database_cross_reference: ISBN:0781735149

myeloid leukocyte mediated immunity
type: Class
subclass of: leukocyte mediated immunity
definition: Any process involved in the carrying out of an immune response by a myeloid leukocyte.
has_exact_synonym: myeloid leucocyte immune effector process
has_exact_synonym: myeloid leucocyte mediated immunity
has_exact_synonym: myeloid leukocyte immune effector process
has_obo_namespace: biological_process
id: GO:0002444

Axiom
annotated source: myeloid leukocyte mediated immunity
annotated property: definition
annotated target: Any process involved in the carrying out of an immune response by a myeloid leukocyte.
database_cross_reference: GOC:add
database_cross_reference: GO_REF:0000022
database_cross_reference: ISBN:0781735149

type II hypersensitivity
type: Class
subclass of: myeloid leukocyte mediated immunity
subclass of: hypersensitivity
subclass of: immunoglobulin mediated immune response
definition: An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors.
database_cross_reference: Wikipedia:Type_II_hypersensitivity
has_obo_namespace: biological_process
id: GO:0002445

Axiom
annotated source: type II hypersensitivity
annotated property: definition
annotated target: An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors.
database_cross_reference: GOC:add
database_cross_reference: ISBN:0781735149

lymphocyte mediated immunity
type: Class
subclass of: leukocyte mediated immunity
definition: Any process involved in the carrying out of an immune response by a lymphocyte.
has_broad_synonym: cell-mediated immunity
has_broad_synonym: cellular immune response
has_obo_namespace: biological_process
id: GO:0002449

Axiom
annotated source: lymphocyte mediated immunity
annotated property: definition
annotated target: Any process involved in the carrying out of an immune response by a lymphocyte.
database_cross_reference: GOC:add
database_cross_reference: GO_REF:0000022
database_cross_reference: ISBN:0781735149

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
type: Class
subclass of: adaptive immune response
definition: An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus.
has_obo_namespace: biological_process
id: GO:0002460

Axiom
annotated source: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
annotated property: definition
annotated target: An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus.
database_cross_reference: GOC:add
database_cross_reference: GOC:mtg_sensu
database_cross_reference: ISBN:0781735149
database_cross_reference: ISBN:1405196831

immune system development
type: Class
subclass of: immune system process
subclass of: system development
definition: The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
has_obo_namespace: biological_process
id: GO:0002520
in_subset: goslim drosophila

Axiom
annotated source: immune system development
annotated property: definition
annotated target: The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
database_cross_reference: GOC:add
database_cross_reference: GOC:dph

hypersensitivity
type: Class
subclass of: acute inflammatory response to antigenic stimulus
definition: An inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system.
database_cross_reference: Wikipedia:Hypersensitivity
has_obo_namespace: biological_process
has_related_synonym: hypersensitivity response
id: GO:0002524

Axiom
annotated source: hypersensitivity
annotated property: definition
annotated target: An inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system.
database_cross_reference: GOC:jal
database_cross_reference: ISBN:0781735149

Axiom
annotated source: hypersensitivity
annotated property: has_related_synonym
annotated target: hypersensitivity response
database_cross_reference: ISBN:0781735149

acute inflammatory response
type: Class
subclass of: inflammatory response
definition: Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.
has_obo_namespace: biological_process
id: GO:0002526

Axiom
annotated source: acute inflammatory response
annotated property: definition
annotated target: Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.
database_cross_reference: GOC:add
database_cross_reference: GO_REF:0000022
database_cross_reference: ISBN:0781735149

regulation of acute inflammatory response
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: acute inflammatory response
subclass of: GO_0050727
subclass of: Restriction
  on property: regulates
  some values from: acute inflammatory response
definition: Any process that modulates the frequency, rate, or extent of an acute inflammatory response.
has_obo_namespace: biological_process
id: GO:0002673

Axiom
annotated source: regulation of acute inflammatory response
annotated property: definition
annotated target: Any process that modulates the frequency, rate, or extent of an acute inflammatory response.
database_cross_reference: GOC:add

negative regulation of acute inflammatory response
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: acute inflammatory response
subclass of: regulation of acute inflammatory response
subclass of: GO_0050728
subclass of: Restriction
  on property: negatively regulates
  some values from: acute inflammatory response
definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response.
has_exact_synonym: down regulation of acute inflammatory response
has_exact_synonym: down-regulation of acute inflammatory response
has_exact_synonym: downregulation of acute inflammatory response
has_narrow_synonym: inhibition of acute inflammatory response
has_obo_namespace: biological_process
id: GO:0002674

Axiom
annotated source: negative regulation of acute inflammatory response
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response.
database_cross_reference: GOC:add

positive regulation of acute inflammatory response
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: acute inflammatory response
subclass of: regulation of acute inflammatory response
subclass of: GO_0050729
subclass of: Restriction
  on property: positively regulates
  some values from: acute inflammatory response
definition: Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response.
has_exact_synonym: up regulation of acute inflammatory response
has_exact_synonym: up-regulation of acute inflammatory response
has_exact_synonym: upregulation of acute inflammatory response
has_narrow_synonym: activation of acute inflammatory response
has_narrow_synonym: stimulation of acute inflammatory response
has_obo_namespace: biological_process
id: GO:0002675

Axiom
annotated source: positive regulation of acute inflammatory response
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response.
database_cross_reference: GOC:add

regulation of immune system process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: immune system process
subclass of: GO_0050789
subclass of: Restriction
  on property: regulates
  some values from: immune system process
definition: Any process that modulates the frequency, rate, or extent of an immune system process.
has_obo_namespace: biological_process
id: GO:0002682

Axiom
annotated source: regulation of immune system process
annotated property: definition
annotated target: Any process that modulates the frequency, rate, or extent of an immune system process.
database_cross_reference: GOC:add

negative regulation of immune system process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: immune system process
subclass of: regulation of immune system process
subclass of: negative regulation of biological process
subclass of: Restriction
  on property: negatively regulates
  some values from: immune system process
definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process.
has_exact_synonym: down regulation of immune system process
has_exact_synonym: down-regulation of immune system process
has_exact_synonym: downregulation of immune system process
has_narrow_synonym: inhibition of immune system process
has_obo_namespace: biological_process
id: GO:0002683

Axiom
annotated source: negative regulation of immune system process
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process.
database_cross_reference: GOC:add

positive regulation of immune system process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: immune system process
subclass of: regulation of immune system process
subclass of: positive regulation of biological process
subclass of: Restriction
  on property: positively regulates
  some values from: immune system process
definition: Any process that activates or increases the frequency, rate, or extent of an immune system process.
has_exact_synonym: up regulation of immune system process
has_exact_synonym: up-regulation of immune system process
has_exact_synonym: upregulation of immune system process
has_narrow_synonym: activation of immune system process
has_narrow_synonym: stimulation of immune system process
has_obo_namespace: biological_process
id: GO:0002684

Axiom
annotated source: positive regulation of immune system process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate, or extent of an immune system process.
database_cross_reference: GOC:add

regulation of leukocyte activation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: leukocyte activation
subclass of: regulation of immune system process
subclass of: GO_0050865
subclass of: Restriction
  on property: regulates
  some values from: leukocyte activation
definition: Any process that modulates the frequency, rate, or extent of leukocyte activation.
has_exact_synonym: regulation of immune cell activation
has_exact_synonym: regulation of leucocyte activation
has_obo_namespace: biological_process
id: GO:0002694

Axiom
annotated source: regulation of leukocyte activation
annotated property: definition
annotated target: Any process that modulates the frequency, rate, or extent of leukocyte activation.
database_cross_reference: GOC:add

negative regulation of leukocyte activation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: leukocyte activation
subclass of: negative regulation of immune system process
subclass of: regulation of leukocyte activation
subclass of: GO_0050866
subclass of: Restriction
  on property: negatively regulates
  some values from: leukocyte activation
definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation.
has_exact_synonym: down regulation of leukocyte activation
has_exact_synonym: down-regulation of leukocyte activation
has_exact_synonym: downregulation of leukocyte activation
has_exact_synonym: negative regulation of immune cell activation
has_exact_synonym: negative regulation of leucocyte activation
has_narrow_synonym: inhibition of leukocyte activation
has_obo_namespace: biological_process
id: GO:0002695

Axiom
annotated source: negative regulation of leukocyte activation
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation.
database_cross_reference: GOC:add

positive regulation of leukocyte activation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: leukocyte activation
subclass of: positive regulation of immune system process
subclass of: regulation of leukocyte activation
subclass of: GO_0050867
subclass of: Restriction
  on property: positively regulates
  some values from: leukocyte activation
definition: Any process that activates or increases the frequency, rate, or extent of leukocyte activation.
has_exact_synonym: positive regulation of immune cell activation
has_exact_synonym: positive regulation of leucocyte activation
has_exact_synonym: up regulation of leukocyte activation
has_exact_synonym: up-regulation of leukocyte activation
has_exact_synonym: upregulation of leukocyte activation
has_narrow_synonym: activation of leukocyte activation
has_narrow_synonym: stimulation of leukocyte activation
has_obo_namespace: biological_process
id: GO:0002696

Axiom
annotated source: positive regulation of leukocyte activation
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate, or extent of leukocyte activation.
database_cross_reference: GOC:add

regulation of immune effector process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: immune effector process
subclass of: regulation of immune system process
subclass of: Restriction
  on property: regulates
  some values from: immune effector process
definition: Any process that modulates the frequency, rate, or extent of an immune effector process.
has_obo_namespace: biological_process
id: GO:0002697

Axiom
annotated source: regulation of immune effector process
annotated property: definition
annotated target: Any process that modulates the frequency, rate, or extent of an immune effector process.
database_cross_reference: GOC:add

negative regulation of immune effector process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: immune effector process
subclass of: negative regulation of immune system process
subclass of: regulation of immune effector process
subclass of: Restriction
  on property: negatively regulates
  some values from: immune effector process
definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process.
has_exact_synonym: down regulation of immune effector process
has_exact_synonym: down-regulation of immune effector process
has_exact_synonym: downregulation of immune effector process
has_narrow_synonym: inhibition of immune effector process
has_obo_namespace: biological_process
id: GO:0002698

Axiom
annotated source: negative regulation of immune effector process
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process.
database_cross_reference: GOC:add

positive regulation of immune effector process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: immune effector process
subclass of: positive regulation of immune system process
subclass of: regulation of immune effector process
subclass of: Restriction
  on property: positively regulates
  some values from: immune effector process
definition: Any process that activates or increases the frequency, rate, or extent of an immune effector process.
has_exact_synonym: up regulation of immune effector process
has_exact_synonym: up-regulation of immune effector process
has_exact_synonym: upregulation of immune effector process
has_narrow_synonym: activation of immune effector process
has_narrow_synonym: stimulation of immune effector process
has_obo_namespace: biological_process
id: GO:0002699

Axiom
annotated source: positive regulation of immune effector process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate, or extent of an immune effector process.
database_cross_reference: GOC:add

regulation of leukocyte mediated immunity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: leukocyte mediated immunity
subclass of: regulation of immune effector process
subclass of: Restriction
  on property: regulates
  some values from: leukocyte mediated immunity
definition: Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity.
has_exact_synonym: regulation of immune cell mediated immunity
has_exact_synonym: regulation of leucocyte mediated immunity
has_obo_namespace: biological_process
id: GO:0002703

Axiom
annotated source: regulation of leukocyte mediated immunity
annotated property: definition
annotated target: Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity.
database_cross_reference: GOC:add

negative regulation of leukocyte mediated immunity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: leukocyte mediated immunity
subclass of: negative regulation of immune effector process
subclass of: regulation of leukocyte mediated immunity
subclass of: Restriction
  on property: negatively regulates
  some values from: leukocyte mediated immunity
definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity.
has_exact_synonym: down regulation of leukocyte mediated immunity
has_exact_synonym: down-regulation of leukocyte mediated immunity
has_exact_synonym: downregulation of leukocyte mediated immunity
has_exact_synonym: negative regulation of immune cell mediated immunity
has_exact_synonym: negative regulation of leucocyte mediated immunity
has_narrow_synonym: inhibition of leukocyte mediated immunity
has_obo_namespace: biological_process
id: GO:0002704

Axiom
annotated source: negative regulation of leukocyte mediated immunity
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity.
database_cross_reference: GOC:add

positive regulation of leukocyte mediated immunity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: leukocyte mediated immunity
subclass of: positive regulation of immune effector process
subclass of: regulation of leukocyte mediated immunity
subclass of: Restriction
  on property: positively regulates
  some values from: leukocyte mediated immunity
definition: Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity.
has_exact_synonym: positive regulation of immune cell mediated immunity
has_exact_synonym: positive regulation of leucocyte mediated immunity
has_exact_synonym: up regulation of leukocyte mediated immunity
has_exact_synonym: up-regulation of leukocyte mediated immunity
has_exact_synonym: upregulation of leukocyte mediated immunity
has_narrow_synonym: activation of leukocyte mediated immunity
has_narrow_synonym: stimulation of leukocyte mediated immunity
has_obo_namespace: biological_process
id: GO:0002705

Axiom
annotated source: positive regulation of leukocyte mediated immunity
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity.
database_cross_reference: GOC:add

regulation of lymphocyte mediated immunity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: lymphocyte mediated immunity
subclass of: regulation of leukocyte mediated immunity
subclass of: Restriction
  on property: regulates
  some values from: lymphocyte mediated immunity
definition: Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity.
has_obo_namespace: biological_process
id: GO:0002706

Axiom
annotated source: regulation of lymphocyte mediated immunity
annotated property: definition
annotated target: Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity.
database_cross_reference: GOC:add

negative regulation of lymphocyte mediated immunity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: lymphocyte mediated immunity
subclass of: negative regulation of leukocyte mediated immunity
subclass of: regulation of lymphocyte mediated immunity
subclass of: Restriction
  on property: negatively regulates
  some values from: lymphocyte mediated immunity
definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity.
has_exact_synonym: down regulation of lymphocyte mediated immunity
has_exact_synonym: down-regulation of lymphocyte mediated immunity
has_exact_synonym: downregulation of lymphocyte mediated immunity
has_narrow_synonym: inhibition of lymphocyte mediated immunity
has_obo_namespace: biological_process
id: GO:0002707

Axiom
annotated source: negative regulation of lymphocyte mediated immunity
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity.
database_cross_reference: GOC:add

positive regulation of lymphocyte mediated immunity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: lymphocyte mediated immunity
subclass of: positive regulation of leukocyte mediated immunity
subclass of: regulation of lymphocyte mediated immunity
subclass of: Restriction
  on property: positively regulates
  some values from: lymphocyte mediated immunity
definition: Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity.
has_exact_synonym: up regulation of lymphocyte mediated immunity
has_exact_synonym: up-regulation of lymphocyte mediated immunity
has_exact_synonym: upregulation of lymphocyte mediated immunity
has_narrow_synonym: activation of lymphocyte mediated immunity
has_narrow_synonym: stimulation of lymphocyte mediated immunity
has_obo_namespace: biological_process
id: GO:0002708

Axiom
annotated source: positive regulation of lymphocyte mediated immunity
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity.
database_cross_reference: GOC:add

regulation of B cell mediated immunity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: B cell mediated immunity
subclass of: regulation of lymphocyte mediated immunity
subclass of: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: Restriction
  on property: regulates
  some values from: B cell mediated immunity
definition: Any process that modulates the frequency, rate, or extent of B cell mediated immunity.
has_exact_synonym: regulation of B lymphocyte mediated immunity
has_exact_synonym: regulation of B-cell mediated immunity
has_exact_synonym: regulation of B-lymphocyte mediated immunity
has_obo_namespace: biological_process
id: GO:0002712

Axiom
annotated source: regulation of B cell mediated immunity
annotated property: definition
annotated target: Any process that modulates the frequency, rate, or extent of B cell mediated immunity.
database_cross_reference: GOC:add

negative regulation of B cell mediated immunity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: B cell mediated immunity
subclass of: negative regulation of lymphocyte mediated immunity
subclass of: regulation of B cell mediated immunity
subclass of: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: Restriction
  on property: negatively regulates
  some values from: B cell mediated immunity
definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell mediated immunity.
has_exact_synonym: down regulation of B cell mediated immunity
has_exact_synonym: down-regulation of B cell mediated immunity
has_exact_synonym: downregulation of B cell mediated immunity
has_exact_synonym: negative regulation of B lymphocyte mediated immunity
has_exact_synonym: negative regulation of B-cell mediated immunity
has_exact_synonym: negative regulation of B-lymphocyte mediated immunity
has_narrow_synonym: inhibition of B cell mediated immunity
has_obo_namespace: biological_process
id: GO:0002713

Axiom
annotated source: negative regulation of B cell mediated immunity
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell mediated immunity.
database_cross_reference: GOC:add

positive regulation of B cell mediated immunity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: B cell mediated immunity
subclass of: positive regulation of lymphocyte mediated immunity
subclass of: regulation of B cell mediated immunity
subclass of: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: Restriction
  on property: positively regulates
  some values from: B cell mediated immunity
definition: Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity.
has_exact_synonym: positive regulation of B lymphocyte mediated immunity
has_exact_synonym: positive regulation of B-cell mediated immunity
has_exact_synonym: positive regulation of B-lymphocyte mediated immunity
has_exact_synonym: up regulation of B cell mediated immunity
has_exact_synonym: up-regulation of B cell mediated immunity
has_exact_synonym: upregulation of B cell mediated immunity
has_narrow_synonym: activation of B cell mediated immunity
has_narrow_synonym: stimulation of B cell mediated immunity
has_obo_namespace: biological_process
id: GO:0002714

Axiom
annotated source: positive regulation of B cell mediated immunity
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity.
database_cross_reference: GOC:add

peptide secretion
type: Class
subclass of: peptide transport
subclass of: secretion
definition: The controlled release of a peptide from a cell or a tissue.
has_obo_namespace: biological_process
id: GO:0002790

Axiom
annotated source: peptide secretion
annotated property: definition
annotated target: The controlled release of a peptide from a cell or a tissue.
database_cross_reference: GOC:add

regulation of peptide secretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: peptide secretion
subclass of: GO_0051046
subclass of: GO_0090087
subclass of: Restriction
  on property: regulates
  some values from: peptide secretion
definition: Any process that modulates the frequency, rate, or extent of peptide secretion.
has_obo_namespace: biological_process
id: GO:0002791

Axiom
annotated source: regulation of peptide secretion
annotated property: definition
annotated target: Any process that modulates the frequency, rate, or extent of peptide secretion.
database_cross_reference: GOC:add

negative regulation of peptide secretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: peptide secretion
subclass of: regulation of peptide secretion
subclass of: GO_0051048
subclass of: Restriction
  on property: negatively regulates
  some values from: peptide secretion
definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion.
has_exact_synonym: down regulation of peptide secretion
has_exact_synonym: down-regulation of peptide secretion
has_exact_synonym: downregulation of peptide secretion
has_narrow_synonym: inhibition of peptide secretion
has_obo_namespace: biological_process
id: GO:0002792

Axiom
annotated source: negative regulation of peptide secretion
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion.
database_cross_reference: GOC:add

positive regulation of peptide secretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: peptide secretion
subclass of: regulation of peptide secretion
subclass of: GO_0051047
subclass of: Restriction
  on property: positively regulates
  some values from: peptide secretion
definition: Any process that activates or increases the frequency, rate, or extent of peptide secretion.
has_exact_synonym: up regulation of peptide secretion
has_exact_synonym: up-regulation of peptide secretion
has_exact_synonym: upregulation of peptide secretion
has_narrow_synonym: activation of peptide secretion
has_narrow_synonym: stimulation of peptide secretion
has_obo_namespace: biological_process
id: GO:0002793

Axiom
annotated source: positive regulation of peptide secretion
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate, or extent of peptide secretion.
database_cross_reference: GOC:add

GO_0002818
type: Class
IAO_0000231: IAO_0000227
term replaced by: cellular defense response
deprecated: true

regulation of adaptive immune response
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: adaptive immune response
subclass of: GO_0050776
subclass of: Restriction
  on property: regulates
  some values from: adaptive immune response
definition: Any process that modulates the frequency, rate, or extent of an adaptive immune response.
has_obo_namespace: biological_process
id: GO:0002819

Axiom
annotated source: regulation of adaptive immune response
annotated property: definition
annotated target: Any process that modulates the frequency, rate, or extent of an adaptive immune response.
database_cross_reference: GOC:add

negative regulation of adaptive immune response
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: adaptive immune response
subclass of: regulation of adaptive immune response
subclass of: GO_0050777
subclass of: Restriction
  on property: negatively regulates
  some values from: adaptive immune response
definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response.
has_exact_synonym: down regulation of adaptive immune response
has_exact_synonym: down-regulation of adaptive immune response
has_exact_synonym: downregulation of adaptive immune response
has_narrow_synonym: inhibition of adaptive immune response
has_obo_namespace: biological_process
id: GO:0002820

Axiom
annotated source: negative regulation of adaptive immune response
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response.
database_cross_reference: GOC:add

positive regulation of adaptive immune response
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: adaptive immune response
subclass of: regulation of adaptive immune response
subclass of: GO_0050778
subclass of: Restriction
  on property: positively regulates
  some values from: adaptive immune response
definition: Any process that activates or increases the frequency, rate, or extent of an adaptive immune response.
has_exact_synonym: up regulation of adaptive immune response
has_exact_synonym: up-regulation of adaptive immune response
has_exact_synonym: upregulation of adaptive immune response
has_narrow_synonym: activation of adaptive immune response
has_narrow_synonym: stimulation of adaptive immune response
has_obo_namespace: biological_process
id: GO:0002821

Axiom
annotated source: positive regulation of adaptive immune response
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate, or extent of an adaptive immune response.
database_cross_reference: GOC:add

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: regulation of adaptive immune response
subclass of: Restriction
  on property: regulates
  some values from: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
definition: Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.
has_obo_namespace: biological_process
id: GO:0002822

Axiom
annotated source: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
annotated property: definition
annotated target: Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.
database_cross_reference: GOC:add
database_cross_reference: GOC:mtg_sensu

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: negative regulation of adaptive immune response
subclass of: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: Restriction
  on property: negatively regulates
  some values from: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.
has_obo_namespace: biological_process
id: GO:0002823

Axiom
annotated source: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.
database_cross_reference: GOC:add
database_cross_reference: GOC:mtg_sensu

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: positive regulation of adaptive immune response
subclass of: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: Restriction
  on property: positively regulates
  some values from: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
definition: Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.
has_obo_namespace: biological_process
id: GO:0002824

Axiom
annotated source: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.
database_cross_reference: GOC:add
database_cross_reference: GOC:mtg_sensu

regulation of response to biotic stimulus
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: response to biotic stimulus
subclass of: regulation of response to stimulus
subclass of: Restriction
  on property: regulates
  some values from: response to biotic stimulus
definition: Any process that modulates the frequency, rate, or extent of a response to biotic stimulus.
has_obo_namespace: biological_process
id: GO:0002831
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: regulation of response to biotic stimulus
annotated property: definition
annotated target: Any process that modulates the frequency, rate, or extent of a response to biotic stimulus.
database_cross_reference: GOC:add

negative regulation of response to biotic stimulus
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: response to biotic stimulus
subclass of: regulation of response to biotic stimulus
subclass of: negative regulation of response to stimulus
subclass of: Restriction
  on property: negatively regulates
  some values from: response to biotic stimulus
definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus.
has_exact_synonym: down regulation of response to biotic stimulus
has_exact_synonym: down-regulation of response to biotic stimulus
has_exact_synonym: downregulation of response to biotic stimulus
has_narrow_synonym: inhibition of response to biotic stimulus
has_obo_namespace: biological_process
id: GO:0002832
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: negative regulation of response to biotic stimulus
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus.
database_cross_reference: GOC:add

positive regulation of response to biotic stimulus
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: response to biotic stimulus
subclass of: regulation of response to biotic stimulus
subclass of: positive regulation of response to stimulus
subclass of: Restriction
  on property: positively regulates
  some values from: response to biotic stimulus
definition: Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus.
has_exact_synonym: up regulation of response to biotic stimulus
has_exact_synonym: up-regulation of response to biotic stimulus
has_exact_synonym: upregulation of response to biotic stimulus
has_narrow_synonym: activation of response to biotic stimulus
has_narrow_synonym: stimulation of response to biotic stimulus
has_obo_namespace: biological_process
id: GO:0002833
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: positive regulation of response to biotic stimulus
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus.
database_cross_reference: GOC:add

regulation of inflammatory response to antigenic stimulus
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: inflammatory response to antigenic stimulus
subclass of: GO_0050727
subclass of: GO_0050776
subclass of: Restriction
  on property: regulates
  some values from: inflammatory response to antigenic stimulus
definition: Any process that modulates the frequency, rate, or extent of an inflammatory response to an antigenic stimulus.
has_obo_namespace: biological_process
id: GO:0002861

Axiom
annotated source: regulation of inflammatory response to antigenic stimulus
annotated property: definition
annotated target: Any process that modulates the frequency, rate, or extent of an inflammatory response to an antigenic stimulus.
database_cross_reference: GOC:add

negative regulation of inflammatory response to antigenic stimulus
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: inflammatory response to antigenic stimulus
subclass of: regulation of inflammatory response to antigenic stimulus
subclass of: GO_0050728
subclass of: GO_0050777
subclass of: Restriction
  on property: negatively regulates
  some values from: inflammatory response to antigenic stimulus
definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus.
has_exact_synonym: down regulation of inflammatory response to antigenic stimulus
has_exact_synonym: down-regulation of inflammatory response to antigenic stimulus
has_exact_synonym: downregulation of inflammatory response to antigenic stimulus
has_narrow_synonym: inhibition of inflammatory response to antigenic stimulus
has_obo_namespace: biological_process
id: GO:0002862

Axiom
annotated source: negative regulation of inflammatory response to antigenic stimulus
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus.
database_cross_reference: GOC:add

positive regulation of inflammatory response to antigenic stimulus
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: inflammatory response to antigenic stimulus
subclass of: regulation of inflammatory response to antigenic stimulus
subclass of: GO_0050729
subclass of: GO_0050778
subclass of: Restriction
  on property: positively regulates
  some values from: inflammatory response to antigenic stimulus
definition: Any process that activates or increases the frequency, rate, or extent of an inflammatory response to an antigenic stimulus.
has_exact_synonym: up regulation of inflammatory response to antigenic stimulus
has_exact_synonym: up-regulation of inflammatory response to antigenic stimulus
has_exact_synonym: upregulation of inflammatory response to antigenic stimulus
has_narrow_synonym: activation of inflammatory response to antigenic stimulus
has_narrow_synonym: stimulation of inflammatory response to antigenic stimulus
has_obo_namespace: biological_process
id: GO:0002863

Axiom
annotated source: positive regulation of inflammatory response to antigenic stimulus
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate, or extent of an inflammatory response to an antigenic stimulus.
database_cross_reference: GOC:add

regulation of acute inflammatory response to antigenic stimulus
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: acute inflammatory response to antigenic stimulus
subclass of: regulation of acute inflammatory response
subclass of: regulation of inflammatory response to antigenic stimulus
subclass of: Restriction
  on property: regulates
  some values from: acute inflammatory response to antigenic stimulus
definition: Any process that modulates the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus.
has_obo_namespace: biological_process
id: GO:0002864

Axiom
annotated source: regulation of acute inflammatory response to antigenic stimulus
annotated property: definition
annotated target: Any process that modulates the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus.
database_cross_reference: GOC:add

negative regulation of acute inflammatory response to antigenic stimulus
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: acute inflammatory response to antigenic stimulus
subclass of: negative regulation of acute inflammatory response
subclass of: negative regulation of inflammatory response to antigenic stimulus
subclass of: regulation of acute inflammatory response to antigenic stimulus
subclass of: Restriction
  on property: negatively regulates
  some values from: acute inflammatory response to antigenic stimulus
definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus.
has_exact_synonym: down regulation of acute inflammatory response to antigenic stimulus
has_exact_synonym: down-regulation of acute inflammatory response to antigenic stimulus
has_exact_synonym: downregulation of acute inflammatory response to antigenic stimulus
has_narrow_synonym: inhibition of acute inflammatory response to antigenic stimulus
has_obo_namespace: biological_process
id: GO:0002865

Axiom
annotated source: negative regulation of acute inflammatory response to antigenic stimulus
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus.
database_cross_reference: GOC:add

positive regulation of acute inflammatory response to antigenic stimulus
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: acute inflammatory response to antigenic stimulus
subclass of: positive regulation of acute inflammatory response
subclass of: positive regulation of inflammatory response to antigenic stimulus
subclass of: regulation of acute inflammatory response to antigenic stimulus
subclass of: Restriction
  on property: positively regulates
  some values from: acute inflammatory response to antigenic stimulus
definition: Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus.
has_exact_synonym: up regulation of acute inflammatory response to antigenic stimulus
has_exact_synonym: up-regulation of acute inflammatory response to antigenic stimulus
has_exact_synonym: upregulation of acute inflammatory response to antigenic stimulus
has_narrow_synonym: activation of acute inflammatory response to antigenic stimulus
has_narrow_synonym: stimulation of acute inflammatory response to antigenic stimulus
has_obo_namespace: biological_process
id: GO:0002866

Axiom
annotated source: positive regulation of acute inflammatory response to antigenic stimulus
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus.
database_cross_reference: GOC:add

regulation of hypersensitivity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: hypersensitivity
subclass of: regulation of acute inflammatory response to antigenic stimulus
subclass of: Restriction
  on property: regulates
  some values from: hypersensitivity
definition: Any process that modulates the frequency, rate, or extent of hypersensitivity.
has_obo_namespace: biological_process
id: GO:0002883

Axiom
annotated source: regulation of hypersensitivity
annotated property: definition
annotated target: Any process that modulates the frequency, rate, or extent of hypersensitivity.
database_cross_reference: GOC:add

negative regulation of hypersensitivity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: hypersensitivity
subclass of: negative regulation of acute inflammatory response to antigenic stimulus
subclass of: regulation of hypersensitivity
subclass of: Restriction
  on property: negatively regulates
  some values from: hypersensitivity
definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of hypersensitivity.
has_exact_synonym: down regulation of hypersensitivity
has_exact_synonym: down-regulation of hypersensitivity
has_exact_synonym: downregulation of hypersensitivity
has_narrow_synonym: inhibition of hypersensitivity
has_obo_namespace: biological_process
id: GO:0002884

Axiom
annotated source: negative regulation of hypersensitivity
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate, or extent of hypersensitivity.
database_cross_reference: GOC:add

positive regulation of hypersensitivity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: hypersensitivity
subclass of: positive regulation of acute inflammatory response to antigenic stimulus
subclass of: regulation of hypersensitivity
subclass of: Restriction
  on property: positively regulates
  some values from: hypersensitivity
definition: Any process that activates or increases the frequency, rate, or extent of hypersensitivity.
has_exact_synonym: up regulation of hypersensitivity
has_exact_synonym: up-regulation of hypersensitivity
has_exact_synonym: upregulation of hypersensitivity
has_narrow_synonym: activation of hypersensitivity
has_narrow_synonym: stimulation of hypersensitivity
has_obo_namespace: biological_process
id: GO:0002885

Axiom
annotated source: positive regulation of hypersensitivity
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate, or extent of hypersensitivity.
database_cross_reference: GOC:add

regulation of myeloid leukocyte mediated immunity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: myeloid leukocyte mediated immunity
subclass of: regulation of leukocyte mediated immunity
subclass of: Restriction
  on property: regulates
  some values from: myeloid leukocyte mediated immunity
definition: Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity.
has_obo_namespace: biological_process
id: GO:0002886

Axiom
annotated source: regulation of myeloid leukocyte mediated immunity
annotated property: definition
annotated target: Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity.
database_cross_reference: GOC:add

negative regulation of myeloid leukocyte mediated immunity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: myeloid leukocyte mediated immunity
subclass of: negative regulation of leukocyte mediated immunity
subclass of: regulation of myeloid leukocyte mediated immunity
subclass of: Restriction
  on property: negatively regulates
  some values from: myeloid leukocyte mediated immunity
definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity.
has_exact_synonym: down regulation of myeloid leukocyte mediated immunity
has_exact_synonym: down-regulation of myeloid leukocyte mediated immunity
has_exact_synonym: downregulation of myeloid leukocyte mediated immunity
has_narrow_synonym: inhibition of myeloid leukocyte mediated immunity
has_obo_namespace: biological_process
id: GO:0002887

Axiom
annotated source: negative regulation of myeloid leukocyte mediated immunity
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity.
database_cross_reference: GOC:add

positive regulation of myeloid leukocyte mediated immunity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: myeloid leukocyte mediated immunity
subclass of: positive regulation of leukocyte mediated immunity
subclass of: regulation of myeloid leukocyte mediated immunity
subclass of: Restriction
  on property: positively regulates
  some values from: myeloid leukocyte mediated immunity
definition: Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity.
has_exact_synonym: up regulation of myeloid leukocyte mediated immunity
has_exact_synonym: up-regulation of myeloid leukocyte mediated immunity
has_exact_synonym: upregulation of myeloid leukocyte mediated immunity
has_narrow_synonym: activation of myeloid leukocyte mediated immunity
has_narrow_synonym: stimulation of myeloid leukocyte mediated immunity
has_obo_namespace: biological_process
id: GO:0002888

Axiom
annotated source: positive regulation of myeloid leukocyte mediated immunity
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity.
database_cross_reference: GOC:add

regulation of immunoglobulin mediated immune response
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: immunoglobulin mediated immune response
subclass of: regulation of B cell mediated immunity
subclass of: Restriction
  on property: regulates
  some values from: immunoglobulin mediated immune response
definition: Any process that modulates the frequency, rate, or extent of an immunoglobulin mediated immune response.
has_obo_namespace: biological_process
id: GO:0002889

Axiom
annotated source: regulation of immunoglobulin mediated immune response
annotated property: definition
annotated target: Any process that modulates the frequency, rate, or extent of an immunoglobulin mediated immune response.
database_cross_reference: GOC:add

negative regulation of immunoglobulin mediated immune response
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: immunoglobulin mediated immune response
subclass of: negative regulation of B cell mediated immunity
subclass of: regulation of immunoglobulin mediated immune response
subclass of: Restriction
  on property: negatively regulates
  some values from: immunoglobulin mediated immune response
definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of an immunoglobulin mediated immune response.
has_exact_synonym: down regulation of immunoglobulin mediated immune response
has_exact_synonym: down-regulation of immunoglobulin mediated immune response
has_exact_synonym: downregulation of immunoglobulin mediated immune response
has_narrow_synonym: inhibition of immunoglobulin mediated immune response
has_obo_namespace: biological_process
id: GO:0002890

Axiom
annotated source: negative regulation of immunoglobulin mediated immune response
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate, or extent of an immunoglobulin mediated immune response.
database_cross_reference: GOC:add

positive regulation of immunoglobulin mediated immune response
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: immunoglobulin mediated immune response
subclass of: positive regulation of B cell mediated immunity
subclass of: regulation of immunoglobulin mediated immune response
subclass of: Restriction
  on property: positively regulates
  some values from: immunoglobulin mediated immune response
definition: Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response.
has_exact_synonym: up regulation of immunoglobulin mediated immune response
has_exact_synonym: up-regulation of immunoglobulin mediated immune response
has_exact_synonym: upregulation of immunoglobulin mediated immune response
has_narrow_synonym: activation of immunoglobulin mediated immune response
has_narrow_synonym: stimulation of immunoglobulin mediated immune response
has_obo_namespace: biological_process
id: GO:0002891

Axiom
annotated source: positive regulation of immunoglobulin mediated immune response
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response.
database_cross_reference: GOC:add

regulation of type II hypersensitivity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: type II hypersensitivity
subclass of: regulation of hypersensitivity
subclass of: regulation of myeloid leukocyte mediated immunity
subclass of: regulation of immunoglobulin mediated immune response
subclass of: Restriction
  on property: regulates
  some values from: type II hypersensitivity
definition: Any process that modulates the frequency, rate, or extent of type II hypersensitivity.
has_obo_namespace: biological_process
id: GO:0002892

Axiom
annotated source: regulation of type II hypersensitivity
annotated property: definition
annotated target: Any process that modulates the frequency, rate, or extent of type II hypersensitivity.
database_cross_reference: GOC:add

negative regulation of type II hypersensitivity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: type II hypersensitivity
subclass of: negative regulation of hypersensitivity
subclass of: negative regulation of myeloid leukocyte mediated immunity
subclass of: negative regulation of immunoglobulin mediated immune response
subclass of: regulation of type II hypersensitivity
subclass of: Restriction
  on property: negatively regulates
  some values from: type II hypersensitivity
definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of type II hypersensitivity.
has_exact_synonym: down regulation of type II hypersensitivity
has_exact_synonym: down-regulation of type II hypersensitivity
has_exact_synonym: downregulation of type II hypersensitivity
has_narrow_synonym: inhibition of type II hypersensitivity
has_obo_namespace: biological_process
id: GO:0002893

Axiom
annotated source: negative regulation of type II hypersensitivity
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate, or extent of type II hypersensitivity.
database_cross_reference: GOC:add

positive regulation of type II hypersensitivity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: type II hypersensitivity
subclass of: positive regulation of hypersensitivity
subclass of: positive regulation of myeloid leukocyte mediated immunity
subclass of: positive regulation of immunoglobulin mediated immune response
subclass of: regulation of type II hypersensitivity
subclass of: Restriction
  on property: positively regulates
  some values from: type II hypersensitivity
definition: Any process that activates or increases the frequency, rate, or extent of type II hypersensitivity.
has_exact_synonym: up regulation of type II hypersensitivity
has_exact_synonym: up-regulation of type II hypersensitivity
has_exact_synonym: upregulation of type II hypersensitivity
has_narrow_synonym: activation of type II hypersensitivity
has_narrow_synonym: stimulation of type II hypersensitivity
has_obo_namespace: biological_process
id: GO:0002894

Axiom
annotated source: positive regulation of type II hypersensitivity
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate, or extent of type II hypersensitivity.
database_cross_reference: GOC:add

developmental process involved in reproduction
type: Class
equivalent class: Class
  intersection of: developmental process
  intersection of: Restriction
    on property: part of
    some values from: reproduction
subclass of: reproductive process
subclass of: developmental process
definition: A developmental process in which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring.
has_narrow_synonym: puberty
has_obo_namespace: biological_process
has_related_synonym: reproductive developmental process
id: GO:0003006

Axiom
annotated source: developmental process involved in reproduction
annotated property: definition
annotated target: A developmental process in which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring.
database_cross_reference: GOC:dph
database_cross_reference: GOC:isa_complete

Axiom
annotated source: developmental process involved in reproduction
annotated property: has_narrow_synonym
annotated target: puberty
database_cross_reference: GOC:dph

Axiom
annotated source: developmental process involved in reproduction
annotated property: has_related_synonym
annotated target: reproductive developmental process
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

system process
type: Class
subclass of: multicellular organismal process
definition: A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.
has_exact_synonym: organ system process
has_obo_namespace: biological_process
id: GO:0003008

Axiom
annotated source: system process
annotated property: definition
annotated target: A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.
database_cross_reference: GOC:mtg_cardio

renal system process
type: Class
subclass of: system process
definition: A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila).
has_exact_synonym: excretory system process
has_obo_namespace: biological_process
has_related_synonym: kidney system process
id: GO:0003014

Axiom
annotated source: renal system process
annotated property: definition
annotated target: A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila).
database_cross_reference: GOC:cjm
database_cross_reference: GOC:mtg_cardio
database_cross_reference: GOC:mtg_kidney_jan10

cilium movement
type: Class
subclass of: microtubule-based movement
definition: The directed, self-propelled movement of a cilium.
never in taxon: NCBITaxon 3176
never in taxon: NCBITaxon 3312
never in taxon: NCBITaxon 3378
never in taxon: NCBITaxon 3398
never in taxon: NCBITaxon 4890
never in taxon: NCBITaxon 5782
created by: dph
creation date: 2009-11-24T09:56:26Z
has_alternative_id: GO:0036142
has_exact_synonym: microtubule-based flagellum movement
has_narrow_synonym: flagellar movement
has_narrow_synonym: flagellum movement
has_obo_namespace: biological_process
has_related_synonym: ciliary motility
has_related_synonym: cilium beating
has_related_synonym: flagellar motility
id: GO:0003341
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.

Axiom
annotated source: cilium movement
annotated property: definition
annotated target: The directed, self-propelled movement of a cilium.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl

Axiom
annotated source: cilium movement
annotated property: has_narrow_synonym
annotated target: flagellar movement
database_cross_reference: GOC:bf

Axiom
annotated source: cilium movement
annotated property: has_related_synonym
annotated target: cilium beating
database_cross_reference: GOC:ascb_2009
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

regulation of cilium movement
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cilium movement
subclass of: GO_0060632
subclass of: Restriction
  on property: regulates
  some values from: cilium movement
definition: Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.
created by: dph
creation date: 2009-12-03T10:12:00Z
has_alternative_id: GO:1900172
has_exact_synonym: regulation of microtubule-based flagellum movement
has_obo_namespace: biological_process
has_related_synonym: regulation of flagellar movement
has_related_synonym: regulation of flagellum movement
id: GO:0003352
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.

Axiom
annotated source: regulation of cilium movement
annotated property: definition
annotated target: Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.
database_cross_reference: GOC:dph

Axiom
annotated source: regulation of cilium movement
annotated property: has_related_synonym
annotated target: regulation of flagellar movement
database_cross_reference: GOC:TermGenie

positive regulation of cilium movement
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: cilium movement
subclass of: regulation of cilium movement
subclass of: GO_0051272
subclass of: Restriction
  on property: positively regulates
  some values from: cilium movement
definition: Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.
created by: dph
creation date: 2009-12-03T10:16:10Z
has_alternative_id: GO:1900174
has_exact_synonym: positive regulation of microtubule-based flagellum movement
has_obo_namespace: biological_process
has_related_synonym: positive regulation of flagellar movement
has_related_synonym: positive regulation of flagellum movement
id: GO:0003353
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.

Axiom
annotated source: positive regulation of cilium movement
annotated property: definition
annotated target: Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.
database_cross_reference: GOC:dph

Axiom
annotated source: positive regulation of cilium movement
annotated property: has_related_synonym
annotated target: positive regulation of flagellar movement
database_cross_reference: GOC:TermGenie

negative regulation of cilium movement
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cilium movement
subclass of: regulation of cilium movement
subclass of: GO_0051271
subclass of: Restriction
  on property: negatively regulates
  some values from: cilium movement
definition: Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.
created by: dph
creation date: 2009-12-03T10:17:47Z
has_alternative_id: GO:1900173
has_exact_synonym: negative regulation of microtubule-based flagellum movement
has_obo_namespace: biological_process
has_related_synonym: negative regulation of flagellum movement
id: GO:0003354
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.

Axiom
annotated source: negative regulation of cilium movement
annotated property: definition
annotated target: Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.
database_cross_reference: GOC:dph

molecular_function
type: Class
subclass of: process
definition: A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process.
OBO foundry unique label: molecular process
has_alternative_id: GO:0005554
has_exact_synonym: molecular function
has_obo_namespace: molecular_function
id: GO:0003674
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast
comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code "no data" (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex.

Axiom
annotated source: molecular_function
annotated property: definition
annotated target: A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process.
database_cross_reference: GOC:pdt

nucleic acid binding
type: Class
subclass of: GO_0097159
subclass of: GO_1901363
definition: Interacting selectively and non-covalently with any nucleic acid.
has_alternative_id: GO:0000496
has_narrow_synonym: base pairing
has_obo_namespace: molecular_function
id: GO:0003676
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant

Axiom
annotated source: nucleic acid binding
annotated property: definition
annotated target: Interacting selectively and non-covalently with any nucleic acid.
database_cross_reference: GOC:jl

DNA binding
type: Class
subclass of: nucleic acid binding
definition: Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
has_alternative_id: GO:0043566
has_narrow_synonym: plasmid binding
has_obo_namespace: molecular_function
has_related_synonym: microtubule/chromatin interaction
has_related_synonym: structure specific DNA binding
has_related_synonym: structure-specific DNA binding
id: GO:0003677
in_subset: goslim agr
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim yeast

Axiom
annotated source: DNA binding
annotated property: definition
annotated target: Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:tb
database_cross_reference: GOC:vw

steroid hormone receptor activity
type: Class
subclass of: signaling receptor activity
subclass of: Restriction
  on property: part of
  some values from: steroid hormone mediated signaling pathway
definition: Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function.
has_obo_namespace: molecular_function
id: GO:0003707
comment: Some steroid hormone receptors reside in the plasma membrane and signal through second messengers or other intracellular signal transduction pathways. For steroid hormone receptors that act in the nucleus to regulate transcription, consider also annotating to the terms: nuclear receptor activity ; GO:0004879' or nuclear receptor transcription coactivator activity ; GO:0030374'.

Axiom
annotated source: steroid hormone receptor activity
annotated property: definition
annotated target: Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function.
database_cross_reference: GOC:signaling
database_cross_reference: PMID:14708019

catalytic activity
type: Class
subclass of: molecular_function
definition: Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
database_cross_reference: Wikipedia:Enzyme
has_exact_synonym: enzyme activity
has_obo_namespace: molecular_function
id: GO:0003824
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant

Axiom
annotated source: catalytic activity
annotated property: definition
annotated target: Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
database_cross_reference: GOC:vw
database_cross_reference: ISBN:0198506732

Axiom
annotated source: catalytic activity
annotated property: has_exact_synonym
annotated target: enzyme activity
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

GO_0004872
type: Class
IAO_0000231: IAO_0000227
term replaced by: signaling receptor activity
deprecated: true

transmembrane signaling receptor activity
type: Class
subclass of: signaling receptor activity
definition: Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
has_alternative_id: GO:0004926
has_alternative_id: GO:0099600
has_broad_synonym: transmembrane receptor activity
database_cross_reference: Reactome:R-HSA-193672
has_exact_synonym: transmembrane signalling receptor activity
has_obo_namespace: molecular_function
id: GO:0004888
comment: This term includes intracellular membrane receptors, e.g. IP3 triggered release of Ca2+ from intracellular stores.

Axiom
annotated source: transmembrane signaling receptor activity
annotated property: definition
annotated target: Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
database_cross_reference: GOC:go_curators
database_cross_reference: Wikipedia:Transmembrane_receptor

Axiom
annotated source: transmembrane signaling receptor activity
annotated property: has_broad_synonym
annotated target: transmembrane receptor activity
database_cross_reference: GOC:bf
database_cross_reference: GOC:signaling

Sphingomyelinase is activated by the NGF:p75NTR complex
type: Axiom
annotated source: transmembrane signaling receptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-193672

Axiom
annotated source: transmembrane signaling receptor activity
annotated property: has_exact_synonym
annotated target: transmembrane signalling receptor activity
database_cross_reference: GOC:mah

G protein-coupled receptor activity
type: Class
subclass of: transmembrane signaling receptor activity
subclass of: Restriction
  on property: part of
  some values from: G protein-coupled receptor signaling pathway
definition: Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
has_alternative_id: GO:0001622
has_alternative_id: GO:0001623
has_alternative_id: GO:0001624
has_alternative_id: GO:0001625
has_alternative_id: GO:0016526
database_cross_reference: Reactome:R-HSA-114552
database_cross_reference: Reactome:R-HSA-114558
database_cross_reference: Reactome:R-HSA-167408
database_cross_reference: Wikipedia:GPCR
has_exact_synonym: G protein coupled receptor activity
has_exact_synonym: G protein linked receptor activity
has_exact_synonym: G-protein coupled receptor activity
has_exact_synonym: G-protein linked receptor activity
has_exact_synonym: GPCR activity
has_exact_synonym: ligand-dependent GPCR activity
has_exact_synonym: receptor activity, G-protein coupled
has_narrow_synonym: EBV-induced receptor
has_narrow_synonym: Epstein-Barr Virus-induced receptor activity
has_narrow_synonym: G-protein coupled receptor activity, unknown ligand
has_narrow_synonym: Mas proto-oncogene receptor activity
has_narrow_synonym: RDC1 receptor activity
has_narrow_synonym: SREB receptor
has_narrow_synonym: orphan G protein coupled receptor activity
has_narrow_synonym: orphan G-protein coupled receptor activity
has_narrow_synonym: orphan GPCR activity
has_narrow_synonym: super conserved receptor expressed in brain receptor activity
has_obo_namespace: molecular_function
id: GO:0004930
in_subset: goslim chembl

Axiom
annotated source: G protein-coupled receptor activity
annotated property: definition
annotated target: Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
database_cross_reference: GOC:bf
database_cross_reference: Wikipedia:GPCR
database_cross_reference: http://www.iuphar-db.org

G12/13 activation by PAR
type: Axiom
annotated source: G protein-coupled receptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-114552

Gq activation by PAR
type: Axiom
annotated source: G protein-coupled receptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-114558

The high affinity receptor complex binds to G-protein
type: Axiom
annotated source: G protein-coupled receptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-167408

Axiom
annotated source: G protein-coupled receptor activity
annotated property: has_exact_synonym
annotated target: receptor activity, G-protein coupled
database_cross_reference: GOC:bf

signaling receptor binding
type: Class
subclass of: protein binding
definition: Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
has_broad_synonym: receptor binding
database_cross_reference: Wikipedia:Ligand_(biochemistry)
has_narrow_synonym: receptor ligand
has_obo_namespace: molecular_function
has_related_synonym: receptor-associated protein activity
id: GO:0005102
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim mouse
in_subset: goslim plant
comment: Where appropriate, also consider annotating to 'receptor agonist activity ; GO:0048018'.

Axiom
annotated source: signaling receptor binding
annotated property: definition
annotated target: Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
database_cross_reference: GOC:bf
database_cross_reference: GOC:ceb
database_cross_reference: ISBN:0198506732

transporter activity
type: Class
subclass of: molecular_function
definition: Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.
has_alternative_id: GO:0005478
database_cross_reference: EC:7
database_cross_reference: Reactome:R-HSA-168313
database_cross_reference: Reactome:R-HSA-178215
has_obo_namespace: molecular_function
has_related_synonym: carrier
id: GO:0005215
in_subset: gocheck do not annotate
in_subset: goslim agr
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
comment: Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules.

Axiom
annotated source: transporter activity
annotated property: definition
annotated target: Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.
database_cross_reference: GOC:ai
database_cross_reference: GOC:dgf

Virion-associated M2 protein mediated ion infusion
type: Axiom
annotated source: transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-168313

SMAD7:SMURF1 complex is exported to the cytosol
type: Axiom
annotated source: transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-178215

dicarboxylic acid transmembrane transporter activity
type: Class
subclass of: carboxylic acid transmembrane transporter activity
subclass of: Restriction
  on property: part of
  some values from: dicarboxylic acid transport
definition: Enables the transfer of dicarboxylic acids from one side of a membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups.
has_alternative_id: GO:0005312
has_alternative_id: GO:0015365
database_cross_reference: Reactome:R-HSA-1614546
database_cross_reference: Reactome:R-HSA-372843
has_narrow_synonym: dicarboxylate carrier
has_narrow_synonym: sodium:dicarboxylate/tricarboxylate symporter activity
has_obo_namespace: molecular_function
has_related_synonym: dicarboxylate (succinate/fumarate/malate) antiporter activity
has_related_synonym: dicarboxylic acid permease activity
id: GO:0005310

Axiom
annotated source: dicarboxylic acid transmembrane transporter activity
annotated property: definition
annotated target: Enables the transfer of dicarboxylic acids from one side of a membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups.
database_cross_reference: GOC:ai

Sulfate is exported to the cytosol in exchange for dicarboxylate
type: Axiom
annotated source: dicarboxylic acid transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1614546

malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]
type: Axiom
annotated source: dicarboxylic acid transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-372843

organic acid transmembrane transporter activity
type: Class
subclass of: transmembrane transporter activity
subclass of: Restriction
  on property: part of
  some values from: GO_1903825
definition: Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage,
has_obo_namespace: molecular_function
id: GO:0005342

Axiom
annotated source: organic acid transmembrane transporter activity
annotated property: definition
annotated target: Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage,
database_cross_reference: ISBN:0198506732

binding
type: Class
subclass of: molecular_function
definition: The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
database_cross_reference: Wikipedia:Binding_(molecular)
has_narrow_synonym: ligand
has_obo_namespace: molecular_function
id: GO:0005488
in_subset: gocheck do not annotate
in_subset: goslim pir
in_subset: goslim plant
comment: Note that this term is in the subset of terms that should not be used for direct, manual gene product annotation. Please choose a more specific child term, or request a new one if no suitable term is available. For ligands that bind to signal transducing receptors, consider the molecular function term 'receptor binding ; GO:0005102' and its children.

Axiom
annotated source: binding
annotated property: definition
annotated target: The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
database_cross_reference: GOC:ceb
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0198506732

protein binding
type: Class
subclass of: binding
definition: Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
has_alternative_id: GO:0001948
has_alternative_id: GO:0045308
database_cross_reference: MIPS_funcat:16.01
database_cross_reference: MIPS_funcat:18.01.07
database_cross_reference: Reactome:R-HSA-170835
database_cross_reference: Reactome:R-HSA-170846
has_exact_synonym: protein amino acid binding
has_narrow_synonym: glycoprotein binding
has_obo_namespace: molecular_function
id: GO:0005515
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant

Axiom
annotated source: protein binding
annotated property: definition
annotated target: Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
database_cross_reference: GOC:go_curators

An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
type: Axiom
annotated source: protein binding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-170835

TGFBR2 recruits TGFBR1
type: Axiom
annotated source: protein binding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-170846

cellular_component
type: Class
definition: A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome).
has_alternative_id: GO:0008372
database_cross_reference: NIF_Subcellular:sao1337158144
has_exact_synonym: cell or subcellular entity
has_exact_synonym: cellular component
has_obo_namespace: cellular_component
has_related_synonym: subcellular entity
id: GO:0005575
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast
comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code "no data" (ND), is used to indicate this.

Axiom
annotated source: cellular_component
annotated property: definition
annotated target: A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome).
database_cross_reference: GOC:pdt
database_cross_reference: NIF_Subcellular:sao1337158144

Axiom
annotated source: cellular_component
annotated property: has_related_synonym
annotated target: subcellular entity
database_cross_reference: NIF_Subcellular:nlx_subcell_100315

extracellular region
type: Class
subclass of: GO_0110165
definition: The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
database_cross_reference: MIPS_funcat:70.27
database_cross_reference: Wikipedia:Extracellular
has_exact_synonym: extracellular
has_obo_namespace: cellular_component
id: GO:0005576
in_subset: goslim agr
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast
comment: Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'.

Axiom
annotated source: extracellular region
annotated property: definition
annotated target: The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
database_cross_reference: GOC:go_curators

extracellular space
type: Class
subclass of: GO_0110165
subclass of: Restriction
  on property: part of
  some values from: extracellular region
definition: That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
database_cross_reference: NIF_Subcellular:sao1425028079
has_obo_namespace: cellular_component
has_related_synonym: intercellular space
id: GO:0005615
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
comment: Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term.

Axiom
annotated source: extracellular space
annotated property: definition
annotated target: That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
database_cross_reference: ISBN:0198547684

cell wall
type: Class
subclass of: external encapsulating structure
definition: The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
never in taxon: NCBITaxon_33208
database_cross_reference: Wikipedia:Cell_wall
has_obo_namespace: cellular_component
id: GO:0005618
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

Axiom
annotated source: cell wall
annotated property: definition
annotated target: The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
database_cross_reference: GOC:giardia
database_cross_reference: ISBN:0198547684
database_cross_reference: PMID:15134259
database_cross_reference: Wikipedia:Microbial_cyst

intracellular
type: Class
subclass of: cellular_component
definition: The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
database_cross_reference: Wikipedia:Intracellular
has_exact_synonym: internal to cell
has_exact_synonym: protoplasm
has_obo_namespace: cellular_component
has_related_synonym: nucleocytoplasm
has_related_synonym: protoplast
id: GO:0005622
in_subset: gocheck do not annotate
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim plant

Axiom
annotated source: intracellular
annotated property: definition
annotated target: The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
database_cross_reference: ISBN:0198506732

Axiom
annotated source: intracellular
annotated property: has_related_synonym
annotated target: nucleocytoplasm
database_cross_reference: GOC:mah

Axiom
annotated source: intracellular
annotated property: has_related_synonym
annotated target: protoplast
database_cross_reference: GOC:mah

cell
type: Class
subclass of: cellular_component
definition: The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
OBO foundry unique label: cell and encapsulating structures
database_cross_reference: NIF_Subcellular:sao1813327414
database_cross_reference: Wikipedia:Cell_(biology)
has_obo_namespace: cellular_component
id: GO:0005623
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim plant

Axiom
annotated source: cell
annotated property: definition
annotated target: The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
database_cross_reference: GOC:go_curators

nucleus
type: Class
subclass of: intracellular membrane-bounded organelle
subclass of: obsolete cell part
definition: A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
imported from: go.owl
database_cross_reference: MIPS_funcat:70.10
database_cross_reference: NIF_Subcellular:sao1702920020
database_cross_reference: Wikipedia:Cell_nucleus
has_exact_synonym: cell nucleus
has_narrow_synonym: horsetail nucleus
has_obo_namespace: cellular_component
id: GO:0005634
in_subset: goslim agr
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

Axiom
annotated source: nucleus
annotated property: definition
annotated target: A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
database_cross_reference: GOC:go_curators

Axiom
annotated source: nucleus
annotated property: has_narrow_synonym
annotated target: horsetail nucleus
database_cross_reference: GOC:al
database_cross_reference: GOC:mah
database_cross_reference: GOC:vw
database_cross_reference: PMID:15030757

nucleolus
type: Class
subclass of: intracellular non-membrane-bounded organelle
subclass of: Restriction
  on property: part of
  some values from: nuclear lumen
definition: A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
database_cross_reference: NIF_Subcellular:sao1820400233
database_cross_reference: Wikipedia:Nucleolus
has_obo_namespace: cellular_component
id: GO:0005730
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

Axiom
annotated source: nucleolus
annotated property: definition
annotated target: A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
database_cross_reference: ISBN:0198506732

cytoplasm
type: Class
subclass of: GO_0110165
subclass of: Restriction
  on property: part of
  some values from: intracellular
definition: All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
database_cross_reference: Wikipedia:Cytoplasm
has_obo_namespace: cellular_component
id: GO:0005737
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

Axiom
annotated source: cytoplasm
annotated property: definition
annotated target: All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
database_cross_reference: ISBN:0198547684

mitochondrion
type: Class
subclass of: intracellular membrane-bounded organelle
subclass of: Restriction
  on property: part of
  some values from: cytoplasm
definition: A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
database_cross_reference: NIF_Subcellular:sao1860313010
database_cross_reference: Wikipedia:Mitochondrion
has_exact_synonym: mitochondria
has_obo_namespace: cellular_component
id: GO:0005739
in_subset: goslim agr
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast
comment: Some anaerobic or microaerophilic organisms (e.g. Entamoeba histolytica, Giardia intestinalis and several Microsporidia species) do not have mitochondria, and contain mitochondrion-related organelles (MROs) instead, called mitosomes or hydrogenosomes, very likely derived from mitochondria. To annotate gene products located in these mitochondrial relics in species such as Entamoeba histolytica, Giardia intestinalis or others, please use GO:0032047 'mitosome' or GO:0042566 'hydrogenosome'. (See PMID:24316280 for a list of species currently known to contain mitochondrion-related organelles.)

Axiom
annotated source: mitochondrion
annotated property: definition
annotated target: A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
database_cross_reference: GOC:giardia
database_cross_reference: ISBN:0198506732

mitochondrial envelope
type: Class
subclass of: organelle envelope
subclass of: Restriction
  on property: part of
  some values from: mitochondrion
definition: The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space.
has_obo_namespace: cellular_component
id: GO:0005740
in_subset: goslim candida
in_subset: goslim yeast

Axiom
annotated source: mitochondrial envelope
annotated property: definition
annotated target: The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space.
database_cross_reference: GOC:ai
database_cross_reference: GOC:pz

mitochondrial intermembrane space
type: Class
subclass of: organelle envelope lumen
subclass of: Restriction
  on property: part of
  some values from: mitochondrial envelope
definition: The region between the inner and outer lipid bilayers of the mitochondrial envelope.
has_alternative_id: GO:0031971
database_cross_reference: NIF_Subcellular:sao118944228
has_exact_synonym: mitochondrial envelope lumen
has_obo_namespace: cellular_component
has_related_synonym: mitochondrial membrane lumen
id: GO:0005758

Axiom
annotated source: mitochondrial intermembrane space
annotated property: definition
annotated target: The region between the inner and outer lipid bilayers of the mitochondrial envelope.
database_cross_reference: GOC:mah

mitochondrial matrix
type: Class
subclass of: GO_0070013
subclass of: Restriction
  on property: part of
  some values from: mitochondrion
definition: The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
has_alternative_id: GO:0031980
database_cross_reference: NIF_Subcellular:sao1804523077
database_cross_reference: Wikipedia:Mitochondrial_matrix
has_exact_synonym: mitochondrial lumen
has_narrow_synonym: mitochondrial stroma
has_obo_namespace: cellular_component
id: GO:0005759

Axiom
annotated source: mitochondrial matrix
annotated property: definition
annotated target: The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
database_cross_reference: GOC:as
database_cross_reference: ISBN:0198506732

lysosome
type: Class
subclass of: lytic vacuole
definition: A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
database_cross_reference: NIF_Subcellular:sao585356902
database_cross_reference: Wikipedia:Lysosome
has_obo_namespace: cellular_component
id: GO:0005764
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim plant

Axiom
annotated source: lysosome
annotated property: definition
annotated target: A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0198506732

vacuole
type: Class
subclass of: intracellular membrane-bounded organelle
subclass of: Restriction
  on property: part of
  some values from: cytoplasm
definition: A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
database_cross_reference: Wikipedia:Vacuole
has_obo_namespace: cellular_component
has_related_synonym: vacuolar carboxypeptidase Y
id: GO:0005773
in_subset: goslim agr
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

Axiom
annotated source: vacuole
annotated property: definition
annotated target: A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
database_cross_reference: GOC:mtg_sensu
database_cross_reference: ISBN:0198506732

vacuolar lumen
type: Class
equivalent class: Class
  intersection of: membrane-enclosed lumen
  intersection of: Restriction
    on property: part of
    some values from: vacuole
subclass of: GO_0070013
subclass of: Restriction
  on property: part of
  some values from: vacuole
definition: The volume enclosed within the vacuolar membrane.
has_obo_namespace: cellular_component
id: GO:0005775

Axiom
annotated source: vacuolar lumen
annotated property: definition
annotated target: The volume enclosed within the vacuolar membrane.
database_cross_reference: ISBN:0198506732

endoplasmic reticulum
type: Class
subclass of: intracellular membrane-bounded organelle
subclass of: Restriction
  on property: part of
  some values from: cytoplasm
subclass of: Restriction
  on property: part of
  some values from: endomembrane system
definition: The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
database_cross_reference: NIF_Subcellular:sao1036339110
database_cross_reference: Wikipedia:Endoplasmic_reticulum
has_exact_synonym: ER
has_obo_namespace: cellular_component
id: GO:0005783
in_subset: goslim agr
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

Axiom
annotated source: endoplasmic reticulum
annotated property: definition
annotated target: The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
database_cross_reference: ISBN:0198506732

endoplasmic reticulum lumen
type: Class
equivalent class: Class
  intersection of: membrane-enclosed lumen
  intersection of: Restriction
    on property: part of
    some values from: endoplasmic reticulum
subclass of: GO_0070013
subclass of: Restriction
  on property: part of
  some values from: endoplasmic reticulum
definition: The volume enclosed by the membranes of the endoplasmic reticulum.
has_alternative_id: GO:0016022
has_exact_synonym: ER cisterna
has_exact_synonym: ER lumen
has_exact_synonym: cisternal lumen
has_exact_synonym: endoplasmic reticulum cisterna
has_obo_namespace: cellular_component
id: GO:0005788

Axiom
annotated source: endoplasmic reticulum lumen
annotated property: definition
annotated target: The volume enclosed by the membranes of the endoplasmic reticulum.
database_cross_reference: ISBN:0198547684

smooth endoplasmic reticulum
type: Class
subclass of: endoplasmic reticulum
definition: The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER.
database_cross_reference: NIF_Subcellular:sao710427438
database_cross_reference: Wikipedia:Endoplasmic_reticulum#Smooth_endoplasmic_reticulum
has_exact_synonym: SER
has_exact_synonym: smooth ER
has_obo_namespace: cellular_component
id: GO:0005790

Axiom
annotated source: smooth endoplasmic reticulum
annotated property: definition
annotated target: The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER.
database_cross_reference: ISBN:0198506732

rough endoplasmic reticulum
type: Class
subclass of: endoplasmic reticulum
definition: The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae.
database_cross_reference: NIF_Subcellular:sao1881364067
database_cross_reference: Wikipedia:Endoplasmic_reticulum#Rough_endoplasmic_reticulum
has_exact_synonym: RER
has_exact_synonym: rough ER
has_obo_namespace: cellular_component
id: GO:0005791

Axiom
annotated source: rough endoplasmic reticulum
annotated property: definition
annotated target: The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae.
database_cross_reference: ISBN:0198506732

Golgi apparatus
type: Class
subclass of: intracellular membrane-bounded organelle
subclass of: Restriction
  on property: part of
  some values from: cytoplasm
subclass of: Restriction
  on property: part of
  some values from: endomembrane system
definition: A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
has_broad_synonym: Golgi
database_cross_reference: NIF_Subcellular:sao451912436
database_cross_reference: Wikipedia:Golgi_apparatus
has_exact_synonym: Golgi complex
has_narrow_synonym: Golgi ribbon
has_obo_namespace: cellular_component
id: GO:0005794
in_subset: goslim agr
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast
comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon.

Axiom
annotated source: Golgi apparatus
annotated property: definition
annotated target: A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
database_cross_reference: ISBN:0198506732

Golgi-associated vesicle
type: Class
subclass of: cytoplasmic vesicle
definition: Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell.
database_cross_reference: NIF_Subcellular:sao819927218
has_obo_namespace: cellular_component
has_related_synonym: Golgi vesicle
has_related_synonym: vesicular component
id: GO:0005798
comment: Note that this definition includes vesicles that are transiently associated with the Golgi.

Axiom
annotated source: Golgi-associated vesicle
annotated property: definition
annotated target: Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell.
database_cross_reference: GOC:mah

Axiom
annotated source: Golgi-associated vesicle
annotated property: has_related_synonym
annotated target: vesicular component
database_cross_reference: NIF_Subcellular:sao138219748

cis-Golgi network
type: Class
subclass of: intracellular membrane-bounded organelle
subclass of: Restriction
  on property: part of
  some values from: Golgi apparatus
definition: The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum.
has_broad_synonym: cis face
database_cross_reference: NIF_Subcellular:sao632188024
has_exact_synonym: cis Golgi network
has_obo_namespace: cellular_component
has_related_synonym: Golgi cis face
has_related_synonym: Golgi cis-face
has_related_synonym: forming face
id: GO:0005801
comment: The CGN is not considered part of the Golgi apparatus but is a separate organelle.

Axiom
annotated source: cis-Golgi network
annotated property: definition
annotated target: The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum.
database_cross_reference: ISBN:0198506732
database_cross_reference: ISBN:0815316194

Axiom
annotated source: cis-Golgi network
annotated property: has_broad_synonym
annotated target: cis face
database_cross_reference: NIF_Subcellular:sao632188024

lipid droplet
type: Class
subclass of: intracellular non-membrane-bounded organelle
definition: An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
has_exact_synonym: adiposome
has_exact_synonym: lipid body
has_exact_synonym: lipid particle
has_obo_namespace: cellular_component
id: GO:0005811
in_subset: goslim chembl
in_subset: goslim generic
comment: Note that this term does not refer to vesicles, but instead to structures in which lipids do not necessarily form bilayers.

Axiom
annotated source: lipid droplet
annotated property: definition
annotated target: An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
database_cross_reference: GOC:mah
database_cross_reference: GOC:tb

spindle
type: Class
subclass of: intracellular non-membrane-bounded organelle
subclass of: Restriction
  on property: part of
  some values from: microtubule cytoskeleton
definition: The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
database_cross_reference: Wikipedia:Spindle_apparatus
has_obo_namespace: cellular_component
id: GO:0005819

Axiom
annotated source: spindle
annotated property: definition
annotated target: The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
database_cross_reference: ISBN:0198547684

cytosol
type: Class
subclass of: GO_0110165
subclass of: Restriction
  on property: part of
  some values from: cytoplasm
definition: The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
database_cross_reference: NIF_Subcellular:sao101633890
database_cross_reference: Wikipedia:Cytosol
has_obo_namespace: cellular_component
id: GO:0005829
in_subset: goslim agr
in_subset: goslim aspergillus
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant

Axiom
annotated source: cytosol
annotated property: definition
annotated target: The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
database_cross_reference: GOC:hjd
database_cross_reference: GOC:jl

polysome
type: Class
subclass of: GO_1990904
definition: A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro.
database_cross_reference: NIF_Subcellular:sao1038025871
database_cross_reference: Wikipedia:Polysome
has_exact_synonym: polyribosome
has_obo_namespace: cellular_component
id: GO:0005844
in_subset: goslim pir

Axiom
annotated source: polysome
annotated property: definition
annotated target: A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro.
database_cross_reference: ISBN:0198506732
database_cross_reference: NIF_Subcellular:sao1038025871

Axiom
annotated source: polysome
annotated property: has_exact_synonym
annotated target: polyribosome
database_cross_reference: NIF_Subcellular:sao1038025871

cytoskeleton
type: Class
subclass of: intracellular non-membrane-bounded organelle
definition: Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
database_cross_reference: Wikipedia:Cytoskeleton
has_obo_namespace: cellular_component
id: GO:0005856
in_subset: goslim agr
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

Axiom
annotated source: cytoskeleton
annotated property: definition
annotated target: Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0198547684
database_cross_reference: PMID:16959967

plasma membrane
type: Class
subclass of: membrane
subclass of: Restriction
  on property: part of
  some values from: GO_0071944
definition: The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
has_alternative_id: GO:0005904
has_broad_synonym: juxtamembrane
database_cross_reference: NIF_Subcellular:sao1663586795
database_cross_reference: Wikipedia:Cell_membrane
has_exact_synonym: cell membrane
has_exact_synonym: cellular membrane
has_exact_synonym: cytoplasmic membrane
has_exact_synonym: plasmalemma
has_narrow_synonym: bacterial inner membrane
has_narrow_synonym: inner endospore membrane
has_narrow_synonym: plasma membrane lipid bilayer
has_obo_namespace: cellular_component
id: GO:0005886
in_subset: goslim agr
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim yeast

Axiom
annotated source: plasma membrane
annotated property: definition
annotated target: The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
database_cross_reference: ISBN:0716731363

Axiom
annotated source: plasma membrane
annotated property: has_exact_synonym
annotated target: cellular membrane
database_cross_reference: NIF_Subcellular:sao6433132645

Axiom
annotated source: plasma membrane
annotated property: has_narrow_synonym
annotated target: plasma membrane lipid bilayer
database_cross_reference: GOC:mah

cilium
type: Class
subclass of: organelle
subclass of: GO_0120025
subclass of: Restriction
  on property: has part
  some values from: intraciliary transport particle
definition: A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
never in taxon: NCBITaxon 3176
never in taxon: NCBITaxon 3312
never in taxon: NCBITaxon 3378
never in taxon: NCBITaxon 3398
never in taxon: NCBITaxon 4890
never in taxon: NCBITaxon 5782
has_alternative_id: GO:0072372
database_cross_reference: FMA:67181
database_cross_reference: NIF_Subcellular:sao787716553
database_cross_reference: Wikipedia:Cilium
has_exact_synonym: eukaryotic flagellum
has_exact_synonym: microtubule-based flagellum
has_narrow_synonym: primary cilium
has_obo_namespace: cellular_component
has_related_synonym: flagellum
id: GO:0005929
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. Also, 'cilium' may be used when axonemal structure and/or motility are unknown, or when axonemal structure is unusual. For all other cases, please refer to children of 'cilium'. Finally, note that any role of ciliary proteins in sensory events should be captured by annotating to relevant biological process terms.

Axiom
annotated source: cilium
annotated property: definition
annotated target: A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
database_cross_reference: GOC:cilia
database_cross_reference: GOC:curators
database_cross_reference: GOC:kmv
database_cross_reference: GOC:vw
database_cross_reference: ISBN:0198547684
database_cross_reference: PMID:16824949
database_cross_reference: PMID:17009929
database_cross_reference: PMID:20144998

cell cortex
type: Class
equivalent class: Class
  intersection of: cytoplasm
  intersection of: Restriction
    on property: part of
    some values from: GO_0071944
subclass of: cytoplasm
subclass of: Restriction
  on property: part of
  some values from: GO_0071944
definition: The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
database_cross_reference: Wikipedia:Cell_cortex
has_obo_namespace: cellular_component
has_related_synonym: cell periphery
has_related_synonym: peripheral cytoplasm
id: GO:0005938
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim yeast

Axiom
annotated source: cell cortex
annotated property: definition
annotated target: The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0815316194

carbohydrate metabolic process
type: Class
subclass of: primary metabolic process
subclass of: GO_0071704
definition: The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
created by: janelomax
creation date: 2012-10-23T15:40:34Z
has_alternative_id: GO:0044261
has_alternative_id: GO:0044723
database_cross_reference: Wikipedia:Carbohydrate_metabolism
has_exact_synonym: carbohydrate metabolism
has_narrow_synonym: multicellular organismal carbohydrate metabolic process
has_obo_namespace: biological_process
has_related_synonym: single-organism carbohydrate metabolic process
id: GO:0005975
in_subset: goslim agr
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim pombe
in_subset: goslim yeast

Axiom
annotated source: carbohydrate metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0198506732

organic acid metabolic process
type: Class
subclass of: cellular metabolic process
subclass of: small molecule metabolic process
subclass of: GO_0071704
definition: The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.
has_exact_synonym: organic acid metabolism
has_obo_namespace: biological_process
id: GO:0006082
in_subset: goslim pir

Axiom
annotated source: organic acid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.
database_cross_reference: ISBN:0198506732

regulation of carbohydrate metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: carbohydrate metabolic process
subclass of: GO_0080090
subclass of: Restriction
  on property: regulates
  some values from: carbohydrate metabolic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates.
has_exact_synonym: regulation of carbohydrate metabolism
has_obo_namespace: biological_process
id: GO:0006109

Axiom
annotated source: regulation of carbohydrate metabolic process
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates.
database_cross_reference: GOC:go_curators

nucleobase-containing compound metabolic process
type: Class
subclass of: cellular aromatic compound metabolic process
subclass of: cellular nitrogen compound metabolic process
subclass of: primary metabolic process
subclass of: heterocycle metabolic process
subclass of: GO_1901360
definition: Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
has_alternative_id: GO:0055134
has_exact_synonym: cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
has_exact_synonym: cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism
has_exact_synonym: nucleobase, nucleoside, nucleotide and nucleic acid metabolism
has_obo_namespace: biological_process
has_related_synonym: nucleobase, nucleoside and nucleotide metabolic process
has_related_synonym: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
id: GO:0006139
in_subset: goslim pir
in_subset: goslim plant

Axiom
annotated source: nucleobase-containing compound metabolic process
annotated property: definition
annotated target: Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
database_cross_reference: GOC:ai

Axiom
annotated source: nucleobase-containing compound metabolic process
annotated property: has_related_synonym
annotated target: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

regulation of nucleotide metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: nucleotide metabolic process
subclass of: regulation of nucleobase-containing compound metabolic process
subclass of: regulation of phosphate metabolic process
subclass of: GO_0062012
subclass of: Restriction
  on property: regulates
  some values from: nucleotide metabolic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides.
has_exact_synonym: regulation of nucleotide metabolism
has_obo_namespace: biological_process
id: GO:0006140

Axiom
annotated source: regulation of nucleotide metabolic process
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides.
database_cross_reference: GOC:go_curators

purine nucleotide metabolic process
type: Class
subclass of: nucleotide metabolic process
subclass of: GO_0072521
definition: The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
has_exact_synonym: purine nucleotide metabolism
has_narrow_synonym: purine metabolic process
has_narrow_synonym: purine metabolism
has_obo_namespace: biological_process
id: GO:0006163

Axiom
annotated source: purine nucleotide metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732

purine nucleotide biosynthetic process
type: Class
subclass of: purine nucleotide metabolic process
subclass of: nucleotide biosynthetic process
subclass of: GO_0072522
definition: The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
database_cross_reference: MetaCyc:DENOVOPURINE2-PWY
has_exact_synonym: purine nucleotide anabolism
has_exact_synonym: purine nucleotide biosynthesis
has_exact_synonym: purine nucleotide formation
has_exact_synonym: purine nucleotide synthesis
has_obo_namespace: biological_process
id: GO:0006164

Axiom
annotated source: purine nucleotide biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732

DNA metabolic process
type: Class
subclass of: cellular macromolecule metabolic process
subclass of: GO_0090304
definition: Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.
has_alternative_id: GO:0055132
has_exact_synonym: DNA metabolism
has_exact_synonym: cellular DNA metabolism
has_obo_namespace: biological_process
id: GO:0006259
in_subset: goslim agr
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant

Axiom
annotated source: DNA metabolic process
annotated property: definition
annotated target: Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.
database_cross_reference: ISBN:0198506732

DNA modification
type: Class
subclass of: DNA metabolic process
subclass of: macromolecule modification
definition: The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties.
has_obo_namespace: biological_process
id: GO:0006304
in_subset: goslim pir

Axiom
annotated source: DNA modification
annotated property: definition
annotated target: The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties.
database_cross_reference: GOC:jl
database_cross_reference: GOC:ma

DNA alkylation
type: Class
subclass of: DNA modification
definition: The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis.
has_obo_namespace: biological_process
id: GO:0006305

Axiom
annotated source: DNA alkylation
annotated property: definition
annotated target: The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis.
database_cross_reference: ISBN:0716735970

DNA methylation
type: Class
subclass of: DNA alkylation
subclass of: macromolecule methylation
subclass of: DNA methylation or demethylation
definition: The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine.
never in taxon: NCBITaxon 4895
never in taxon: NCBITaxon 4930
database_cross_reference: Wikipedia:DNA_methylation
has_obo_namespace: biological_process
id: GO:0006306

Axiom
annotated source: DNA methylation
annotated property: definition
annotated target: The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine.
database_cross_reference: GOC:ems
database_cross_reference: ISBN:0198506732

DNA packaging
type: Class
subclass of: GO_0071103
subclass of: Restriction
  on property: has part
  some values from: DNA binding, bending
definition: Any process in which DNA and associated proteins are formed into a compact, orderly structure.
has_exact_synonym: DNA condensation
has_exact_synonym: DNA organisation
has_exact_synonym: DNA organization
has_obo_namespace: biological_process
id: GO:0006323
in_subset: goslim pir

Axiom
annotated source: DNA packaging
annotated property: definition
annotated target: Any process in which DNA and associated proteins are formed into a compact, orderly structure.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0815316194

transcription, DNA-templated
type: Class
subclass of: cellular macromolecule biosynthetic process
subclass of: GO_0097659
subclass of: Restriction
  on property: part of
  some values from: gene expression
definition: The cellular synthesis of RNA on a template of DNA.
has_alternative_id: GO:0006350
has_alternative_id: GO:0061018
has_alternative_id: GO:0061022
has_broad_synonym: cellular transcription
has_broad_synonym: transcription
database_cross_reference: Wikipedia:Transcription_(genetics)
has_exact_synonym: DNA-dependent transcription
has_exact_synonym: cellular transcription, DNA-dependent
has_exact_synonym: transcription, DNA-dependent
has_obo_namespace: biological_process
has_related_synonym: transcription regulator activity
id: GO:0006351
in_subset: goslim aspergillus
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim pombe

Axiom
annotated source: transcription, DNA-templated
annotated property: definition
annotated target: The cellular synthesis of RNA on a template of DNA.
database_cross_reference: GOC:jl
database_cross_reference: GOC:txnOH

Axiom
annotated source: transcription, DNA-templated
annotated property: has_exact_synonym
annotated target: transcription, DNA-dependent
database_cross_reference: GOC:txnOH

regulation of transcription, DNA-templated
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: transcription, DNA-templated
subclass of: regulation of gene expression
subclass of: GO_1903506
subclass of: GO_2000112
subclass of: Restriction
  on property: regulates
  some values from: transcription, DNA-templated
definition: Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
has_alternative_id: GO:0032583
has_alternative_id: GO:0045449
has_alternative_id: GO:0061019
has_broad_synonym: transcriptional control
has_exact_synonym: regulation of cellular transcription, DNA-dependent
has_exact_synonym: regulation of transcription, DNA-dependent
has_obo_namespace: biological_process
has_related_synonym: regulation of gene-specific transcription
id: GO:0006355

Axiom
annotated source: regulation of transcription, DNA-templated
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:txnOH

Axiom
annotated source: regulation of transcription, DNA-templated
annotated property: has_exact_synonym
annotated target: regulation of transcription, DNA-dependent
database_cross_reference: GOC:txnOH

regulation of transcription by RNA polymerase II
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: transcription by RNA polymerase II
subclass of: regulation of transcription, DNA-templated
subclass of: Restriction
  on property: regulates
  some values from: transcription by RNA polymerase II
definition: Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
has_alternative_id: GO:0006358
has_alternative_id: GO:0010551
has_exact_synonym: regulation of transcription from Pol II promoter
has_exact_synonym: regulation of transcription from RNA polymerase II promoter
has_obo_namespace: biological_process
has_related_synonym: global transcription regulation from Pol II promoter
has_related_synonym: regulation of gene-specific transcription from RNA polymerase II promoter
has_related_synonym: regulation of global transcription from Pol II promoter
has_related_synonym: regulation of transcription from RNA polymerase II promoter, global
id: GO:0006357

Axiom
annotated source: regulation of transcription by RNA polymerase II
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:txnOH

transcription by RNA polymerase II
type: Class
subclass of: transcription, DNA-templated
definition: The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
IAO_0000233: https://github.com/geneontology/go-ontology/issues/14854
has_alternative_id: GO:0032568
has_alternative_id: GO:0032569
has_exact_synonym: transcription from Pol II promoter
has_exact_synonym: transcription from RNA polymerase II promoter
has_obo_namespace: biological_process
has_related_synonym: RNA polymerase II transcription factor activity
has_related_synonym: gene-specific transcription from RNA polymerase II promoter
has_related_synonym: general transcription from RNA polymerase II promoter
has_related_synonym: specific transcription from RNA polymerase II promoter
id: GO:0006366
in_subset: goslim yeast

Axiom
annotated source: transcription by RNA polymerase II
annotated property: definition
annotated target: The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
database_cross_reference: GOC:jl
database_cross_reference: GOC:txnOH
database_cross_reference: ISBN:0321000382

Axiom
annotated source: transcription by RNA polymerase II
annotated property: has_related_synonym
annotated target: specific transcription from RNA polymerase II promoter
database_cross_reference: GOC:mah

mitochondrial transcription
type: Class
equivalent class: Class
  intersection of: transcription, DNA-templated
  intersection of: Restriction
    on property: part of
    some values from: GO_0140053
  intersection of: Restriction
    on property: occurs in
    some values from: mitochondrion
subclass of: mitochondrial RNA metabolic process
subclass of: transcription, DNA-templated
subclass of: Restriction
  on property: part of
  some values from: GO_0140053
definition: The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase.
IAO_0000233: https://github.com/geneontology/go-ontology/issues/14854
has_exact_synonym: transcription from mitochondrial promoter
has_obo_namespace: biological_process
id: GO:0006390

Axiom
annotated source: mitochondrial transcription
annotated property: definition
annotated target: The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase.
database_cross_reference: GOC:jl

cellular protein modification process
type: Class
subclass of: protein modification process
subclass of: cellular protein metabolic process
definition: The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
has_broad_synonym: protein modification process
has_obo_namespace: biological_process
has_related_synonym: process resulting in protein modification
has_related_synonym: protein tagging activity
id: GO:0006464
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant

Axiom
annotated source: cellular protein modification process
annotated property: definition
annotated target: The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
database_cross_reference: GOC:go_curators

Axiom
annotated source: cellular protein modification process
annotated property: has_broad_synonym
annotated target: protein modification process
database_cross_reference: GOC:bf
database_cross_reference: GOC:jl

protein phosphorylation
type: Class
subclass of: cellular protein modification process
subclass of: phosphorylation
definition: The process of introducing a phosphate group on to a protein.
has_exact_synonym: protein amino acid phosphorylation
has_obo_namespace: biological_process
id: GO:0006468
in_subset: goslim yeast

Axiom
annotated source: protein phosphorylation
annotated property: definition
annotated target: The process of introducing a phosphate group on to a protein.
database_cross_reference: GOC:hb

Axiom
annotated source: protein phosphorylation
annotated property: has_exact_synonym
annotated target: protein amino acid phosphorylation
database_cross_reference: GOC:bf

protein glycosylation
type: Class
subclass of: cellular protein modification process
subclass of: macromolecule glycosylation
subclass of: Restriction
  on property: part of
  some values from: glycoprotein biosynthetic process
definition: A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
has_alternative_id: GO:0065006
has_exact_synonym: protein amino acid glycosylation
has_obo_namespace: biological_process
has_related_synonym: protein-carbohydrate complex assembly
id: GO:0006486
in_subset: goslim pombe
in_subset: goslim yeast

Axiom
annotated source: protein glycosylation
annotated property: definition
annotated target: A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
database_cross_reference: GOC:curators
database_cross_reference: GOC:pr

Axiom
annotated source: protein glycosylation
annotated property: has_exact_synonym
annotated target: protein amino acid glycosylation
database_cross_reference: GOC:bf

protein N-linked glycosylation
type: Class
subclass of: protein glycosylation
definition: A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan.
database_cross_reference: RESID:AA0151
database_cross_reference: RESID:AA0156
database_cross_reference: RESID:AA0327
has_exact_synonym: protein amino acid N-linked glycosylation
has_obo_namespace: biological_process
has_related_synonym: N-glycan biosynthesis
has_related_synonym: N-glycan metabolism
id: GO:0006487

Axiom
annotated source: protein N-linked glycosylation
annotated property: definition
annotated target: A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan.
database_cross_reference: GOC:pr
database_cross_reference: RESID:AA0151
database_cross_reference: RESID:AA0156
database_cross_reference: RESID:AA0327

Axiom
annotated source: protein N-linked glycosylation
annotated property: has_exact_synonym
annotated target: protein amino acid N-linked glycosylation
database_cross_reference: GOC:bf

proteolysis
type: Class
subclass of: protein metabolic process
definition: The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
database_cross_reference: Wikipedia:Proteolysis
has_exact_synonym: peptidolysis
has_narrow_synonym: ATP-dependent proteolysis
has_obo_namespace: biological_process
id: GO:0006508
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim pir
comment: This term was intentionally placed under 'protein metabolic process ; GO:0019538' rather than 'protein catabolic process ; GO:0030163' to cover all processes centered on breaking peptide bonds, including those involved in protein processing.

Axiom
annotated source: proteolysis
annotated property: definition
annotated target: The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
database_cross_reference: GOC:bf
database_cross_reference: GOC:mah

Axiom
annotated source: proteolysis
annotated property: has_narrow_synonym
annotated target: ATP-dependent proteolysis
database_cross_reference: GOC:mah

cellular modified amino acid metabolic process
type: Class
subclass of: cellular metabolic process
subclass of: GO_1901564
definition: The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents.
has_exact_synonym: amino acid derivative metabolic process
has_exact_synonym: cellular amino acid derivative metabolic process
has_exact_synonym: cellular amino acid derivative metabolism
has_exact_synonym: cellular modified amino acid metabolism
has_exact_synonym: modified amino acid metabolic process
has_exact_synonym: modified amino acid metabolism
has_obo_namespace: biological_process
id: GO:0006575

Axiom
annotated source: cellular modified amino acid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents.
database_cross_reference: GOC:ai

Axiom
annotated source: cellular modified amino acid metabolic process
annotated property: has_exact_synonym
annotated target: cellular modified amino acid metabolism
database_cross_reference: GOC:mah

Axiom
annotated source: cellular modified amino acid metabolic process
annotated property: has_exact_synonym
annotated target: modified amino acid metabolic process
database_cross_reference: GOC:mah

Axiom
annotated source: cellular modified amino acid metabolic process
annotated property: has_exact_synonym
annotated target: modified amino acid metabolism
database_cross_reference: GOC:mah

lipid metabolic process
type: Class
subclass of: primary metabolic process
subclass of: GO_0071704
definition: The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
database_cross_reference: Wikipedia:Lipid_metabolism
has_exact_synonym: lipid metabolism
has_obo_namespace: biological_process
id: GO:0006629
in_subset: goslim agr
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim pombe
in_subset: goslim yeast

Axiom
annotated source: lipid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
database_cross_reference: GOC:ma

isoprenoid metabolic process
type: Class
subclass of: cellular lipid metabolic process
definition: The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.
has_alternative_id: GO:0016096
has_exact_synonym: isoprenoid metabolism
has_narrow_synonym: polyisoprenoid metabolic process
has_narrow_synonym: polyisoprenoid metabolism
has_narrow_synonym: polyterpene metabolic process
has_narrow_synonym: polyterpene metabolism
has_obo_namespace: biological_process
id: GO:0006720

Axiom
annotated source: isoprenoid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.
database_cross_reference: ISBN:0198547684

terpenoid metabolic process
type: Class
subclass of: isoprenoid metabolic process
definition: The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups.
has_exact_synonym: terpenoid metabolism
has_obo_namespace: biological_process
id: GO:0006721

Axiom
annotated source: terpenoid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups.
database_cross_reference: ISBN:0198506732

cellular aromatic compound metabolic process
type: Class
subclass of: cellular metabolic process
definition: The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.
has_exact_synonym: aromatic compound metabolism
has_narrow_synonym: aromatic hydrocarbon metabolic process
has_narrow_synonym: aromatic hydrocarbon metabolism
has_obo_namespace: biological_process
id: GO:0006725
in_subset: goslim pir

Axiom
annotated source: cellular aromatic compound metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.
database_cross_reference: GOC:ai
database_cross_reference: ISBN:0198506732

coenzyme metabolic process
type: Class
subclass of: GO_0051186
definition: The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.
has_alternative_id: GO:0006752
has_broad_synonym: coenzyme and prosthetic group metabolic process
has_broad_synonym: coenzyme and prosthetic group metabolism
has_exact_synonym: coenzyme metabolism
has_narrow_synonym: group transfer coenzyme metabolic process
has_narrow_synonym: group transfer coenzyme metabolism
has_obo_namespace: biological_process
id: GO:0006732

Axiom
annotated source: coenzyme metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.
database_cross_reference: ISBN:0198506732

nucleoside phosphate metabolic process
type: Class
subclass of: phosphate-containing compound metabolic process
subclass of: organophosphate metabolic process
subclass of: GO_0055086
definition: The chemical reactions and pathways involving any phosphorylated nucleoside.
has_exact_synonym: nucleoside phosphate metabolism
has_obo_namespace: biological_process
id: GO:0006753

Axiom
annotated source: nucleoside phosphate metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving any phosphorylated nucleoside.
database_cross_reference: GOC:mah

ATP biosynthetic process
type: Class
subclass of: purine ribonucleotide biosynthetic process
subclass of: purine ribonucleoside triphosphate biosynthetic process
subclass of: drug metabolic process
subclass of: ATP metabolic process
definition: The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
has_alternative_id: GO:0006758
has_alternative_id: GO:0006759
has_exact_synonym: ATP anabolism
has_exact_synonym: ATP biosynthesis
has_exact_synonym: ATP formation
has_exact_synonym: ATP synthesis
has_narrow_synonym: ATP regeneration
has_obo_namespace: biological_process
id: GO:0006754

Axiom
annotated source: ATP biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732

folic acid-containing compound metabolic process
type: Class
subclass of: cellular modified amino acid metabolic process
subclass of: coenzyme metabolic process
subclass of: carboxylic acid metabolic process
subclass of: pteridine-containing compound metabolic process
subclass of: cellular amide metabolic process
definition: The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units.
has_exact_synonym: folate and derivative metabolic process
has_exact_synonym: folate and derivative metabolism
has_exact_synonym: folate-containing compound metabolic process
has_exact_synonym: folate-containing compound metabolism
has_exact_synonym: folic acid and derivative metabolic process
has_exact_synonym: folic acid and derivative metabolism
has_exact_synonym: folic acid-containing compound metabolism
has_exact_synonym: vitamin B9 and derivative metabolic process
has_exact_synonym: vitamin B9 and derivative metabolism
has_exact_synonym: vitamin M and derivative metabolic process
has_exact_synonym: vitamin M and derivative metabolism
has_obo_namespace: biological_process
id: GO:0006760

Axiom
annotated source: folic acid-containing compound metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units.
database_cross_reference: GOC:ai
database_cross_reference: GOC:mah

vitamin metabolic process
type: Class
subclass of: small molecule metabolic process
definition: The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems.
has_exact_synonym: vitamin metabolism
has_obo_namespace: biological_process
id: GO:0006766
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim yeast

Axiom
annotated source: vitamin metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems.
database_cross_reference: GOC:ai

water-soluble vitamin metabolic process
type: Class
subclass of: vitamin metabolic process
definition: The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water.
has_exact_synonym: water-soluble vitamin metabolism
has_obo_namespace: biological_process
id: GO:0006767

Axiom
annotated source: water-soluble vitamin metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water.
database_cross_reference: GOC:jl

biotin metabolic process
type: Class
subclass of: coenzyme metabolic process
subclass of: water-soluble vitamin metabolic process
subclass of: sulfur compound metabolic process
subclass of: drug metabolic process
subclass of: monocarboxylic acid metabolic process
subclass of: cellular amide metabolic process
subclass of: heterocycle metabolic process
subclass of: GO_1901360
subclass of: GO_1901564
definition: The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions.
database_cross_reference: Wikipedia:Biotin
has_exact_synonym: biotin metabolism
has_exact_synonym: vitamin B7 metabolic process
has_exact_synonym: vitamin B7 metabolism
has_exact_synonym: vitamin H metabolic process
has_exact_synonym: vitamin H metabolism
has_obo_namespace: biological_process
id: GO:0006768

Axiom
annotated source: biotin metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions.
database_cross_reference: ISBN:0198506732

thiamine metabolic process
type: Class
subclass of: thiamine-containing compound metabolic process
definition: The chemical reactions and pathways involving thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.
database_cross_reference: Wikipedia:Thiamine
has_exact_synonym: thiamin metabolic process
has_exact_synonym: thiamin metabolism
has_exact_synonym: thiamine metabolism
has_exact_synonym: vitamin B1 metabolic process
has_exact_synonym: vitamin B1 metabolism
has_obo_namespace: biological_process
id: GO:0006772

Axiom
annotated source: thiamine metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732

fat-soluble vitamin metabolic process
type: Class
subclass of: vitamin metabolic process
definition: The chemical reactions and pathways involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water.
has_exact_synonym: fat-soluble vitamin metabolism
has_obo_namespace: biological_process
id: GO:0006775

Axiom
annotated source: fat-soluble vitamin metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732

vitamin A metabolic process
type: Class
subclass of: retinoid metabolic process
subclass of: fat-soluble vitamin metabolic process
definition: The chemical reactions and pathways involving any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid, all of which are derivatives of beta-carotene.
has_exact_synonym: vitamin A metabolism
has_obo_namespace: biological_process
id: GO:0006776

Axiom
annotated source: vitamin A metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid, all of which are derivatives of beta-carotene.
database_cross_reference: GOC:jl
database_cross_reference: http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k

sulfur compound metabolic process
type: Class
subclass of: cellular metabolic process
definition: The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.
database_cross_reference: Wikipedia:Sulfur_metabolism
has_exact_synonym: sulfur metabolism
has_exact_synonym: sulphur metabolic process
has_exact_synonym: sulphur metabolism
has_obo_namespace: biological_process
id: GO:0006790
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe

Axiom
annotated source: sulfur compound metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.
database_cross_reference: GOC:ai

phosphorus metabolic process
type: Class
subclass of: cellular metabolic process
definition: The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4).
has_exact_synonym: phosphorus metabolism
has_obo_namespace: biological_process
id: GO:0006793
in_subset: goslim pir

Axiom
annotated source: phosphorus metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4).
database_cross_reference: GOC:ai

phosphate-containing compound metabolic process
type: Class
subclass of: phosphorus metabolic process
definition: The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid.
database_cross_reference: MIPS_funcat:01.04
has_exact_synonym: phosphate metabolism
has_obo_namespace: biological_process
has_related_synonym: phosphate metabolic process
id: GO:0006796

Axiom
annotated source: phosphate-containing compound metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid.
database_cross_reference: GOC:ai

nitrogen compound metabolic process
type: Class
subclass of: metabolic process
definition: The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.
has_exact_synonym: nitrogen compound metabolism
has_obo_namespace: biological_process
id: GO:0006807
in_subset: goslim metagenomics
in_subset: goslim pir

Axiom
annotated source: nitrogen compound metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732

transport
type: Class
subclass of: GO_0051234
definition: The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter, pore or motor protein.
created by: janelomax
creation date: 2012-12-13T16:25:32Z
has_alternative_id: GO:0015457
has_alternative_id: GO:0015460
has_alternative_id: GO:0044765
has_narrow_synonym: small molecule transport
has_narrow_synonym: solute:solute exchange
has_obo_namespace: biological_process
has_related_synonym: single-organism transport
id: GO:0006810
in_subset: gocheck do not annotate
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
comment: Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport.

Axiom
annotated source: transport
annotated property: definition
annotated target: The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter, pore or motor protein.
database_cross_reference: GOC:dos
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

ion transport
type: Class
subclass of: transport
definition: The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has_obo_namespace: biological_process
id: GO:0006811
in_subset: goslim drosophila
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: ion transport
annotated property: definition
annotated target: The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
database_cross_reference: GOC:ai

anion transport
type: Class
subclass of: ion transport
definition: The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has_alternative_id: GO:0006822
has_obo_namespace: biological_process
id: GO:0006820

Axiom
annotated source: anion transport
annotated property: definition
annotated target: The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
database_cross_reference: GOC:ai

dicarboxylic acid transport
type: Class
subclass of: carboxylic acid transport
definition: The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has_alternative_id: GO:0006841
has_obo_namespace: biological_process
has_related_synonym: sodium:dicarboxylate transport
id: GO:0006835

Axiom
annotated source: dicarboxylic acid transport
annotated property: definition
annotated target: The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
database_cross_reference: GOC:krc

drug transmembrane transport
type: Class
subclass of: drug transport
subclass of: GO_0055085
definition: The process in which a drug is transported across a membrane.
has_exact_synonym: drug membrane transport
has_obo_namespace: biological_process
has_related_synonym: multidrug transport
id: GO:0006855
comment: Note that this term is not intended for use in annotating lateral movement within membranes.

Axiom
annotated source: drug transmembrane transport
annotated property: definition
annotated target: The process in which a drug is transported across a membrane.
database_cross_reference: GOC:ai
database_cross_reference: GOC:bf

extracellular transport
type: Class
equivalent class: Class
  intersection of: transport
  intersection of: Restriction
    on property: occurs in
    some values from: extracellular region
subclass of: transport
subclass of: Restriction
  on property: occurs in
  some values from: extracellular region
definition: The transport of substances that occurs outside cells.
has_obo_namespace: biological_process
id: GO:0006858

Axiom
annotated source: extracellular transport
annotated property: definition
annotated target: The transport of substances that occurs outside cells.
database_cross_reference: GOC:go_curators

cellular ion homeostasis
type: Class
subclass of: GO_0050801
subclass of: GO_0055082
definition: Any process involved in the maintenance of an internal steady state of ions at the level of a cell.
has_obo_namespace: biological_process
id: GO:0006873
in_subset: goslim yeast

Axiom
annotated source: cellular ion homeostasis
annotated property: definition
annotated target: Any process involved in the maintenance of an internal steady state of ions at the level of a cell.
database_cross_reference: GOC:mah

cellular calcium ion homeostasis
type: Class
subclass of: cellular metal ion homeostasis
subclass of: GO_0055074
subclass of: GO_0072503
definition: Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
has_broad_synonym: regulation of calcium ion concentration
has_obo_namespace: biological_process
id: GO:0006874

Axiom
annotated source: cellular calcium ion homeostasis
annotated property: definition
annotated target: Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
database_cross_reference: GOC:ceb
database_cross_reference: GOC:mah

cellular metal ion homeostasis
type: Class
subclass of: cellular cation homeostasis
subclass of: GO_0055065
definition: Any process involved in the maintenance of an internal steady state of metal ions at the level of a cell.
has_narrow_synonym: cellular heavy metal ion homeostasis
has_obo_namespace: biological_process
id: GO:0006875

Axiom
annotated source: cellular metal ion homeostasis
annotated property: definition
annotated target: Any process involved in the maintenance of an internal steady state of metal ions at the level of a cell.
database_cross_reference: GOC:ai
database_cross_reference: GOC:mah

intracellular protein transport
type: Class
subclass of: protein transport
subclass of: intracellular transport
subclass of: Restriction
  on property: part of
  some values from: cellular protein localization
definition: The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
has_alternative_id: GO:0032779
has_obo_namespace: biological_process
has_related_synonym: copper-induced intracellular protein transport
id: GO:0006886

Axiom
annotated source: intracellular protein transport
annotated property: definition
annotated target: The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
database_cross_reference: GOC:mah

Axiom
annotated source: intracellular protein transport
annotated property: has_related_synonym
annotated target: copper-induced intracellular protein transport
database_cross_reference: GOC:al

vesicle budding from membrane
type: Class
subclass of: vesicle organization
subclass of: GO_0061024
subclass of: Restriction
  on property: part of
  some values from: vesicle-mediated transport
definition: The evagination of a membrane, resulting in formation of a vesicle.
created by: jl
creation date: 2013-12-19T15:26:17Z
has_alternative_id: GO:0006902
has_alternative_id: GO:1902591
has_exact_synonym: membrane evagination
has_exact_synonym: vesicle biosynthesis
has_exact_synonym: vesicle formation
has_obo_namespace: biological_process
has_related_synonym: nonselective vesicle assembly
has_related_synonym: single organism membrane budding
has_related_synonym: single-organism membrane budding
has_related_synonym: vesicle budding
id: GO:0006900

Axiom
annotated source: vesicle budding from membrane
annotated property: definition
annotated target: The evagination of a membrane, resulting in formation of a vesicle.
database_cross_reference: GOC:jid
database_cross_reference: GOC:tb

Axiom
annotated source: vesicle budding from membrane
annotated property: has_related_synonym
annotated target: single organism membrane budding
database_cross_reference: GOC:TermGenie

vesicle targeting
type: Class
subclass of: cellular process
subclass of: Restriction
  on property: part of
  some values from: vesicle-mediated transport
subclass of: Restriction
  on property: part of
  some values from: GO_0051650
definition: The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo.
has_obo_namespace: biological_process
id: GO:0006903

Axiom
annotated source: vesicle targeting
annotated property: definition
annotated target: The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo.
database_cross_reference: GOC:mah
database_cross_reference: PMID:17335816

autophagy
type: Class
subclass of: cellular catabolic process
subclass of: GO_0061919
definition: The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
has_alternative_id: GO:0016238
database_cross_reference: Wikipedia:Autophagy_(cellular)
has_obo_namespace: biological_process
id: GO:0006914
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe

Axiom
annotated source: autophagy
annotated property: definition
annotated target: The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
database_cross_reference: GOC:autophagy
database_cross_reference: ISBN:0198547684
database_cross_reference: PMID:11099404
database_cross_reference: PMID:9412464

apoptotic process
type: Class
subclass of: programmed cell death
definition: A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
has_alternative_id: GO:0006917
has_alternative_id: GO:0008632
has_broad_synonym: cell suicide
has_broad_synonym: cellular suicide
database_cross_reference: Wikipedia:Apoptosis
has_exact_synonym: apoptotic cell death
has_exact_synonym: apoptotic programmed cell death
has_exact_synonym: programmed cell death by apoptosis
has_narrow_synonym: activation of apoptosis
has_narrow_synonym: apoptosis
has_narrow_synonym: apoptosis signaling
has_narrow_synonym: apoptotic program
has_narrow_synonym: type I programmed cell death
has_obo_namespace: biological_process
has_related_synonym: apoptosis activator activity
has_related_synonym: caspase-dependent programmed cell death
has_related_synonym: commitment to apoptosis
has_related_synonym: induction of apoptosis
has_related_synonym: induction of apoptosis by p53
has_related_synonym: signaling (initiator) caspase activity
id: GO:0006915
in_subset: goslim pombe

Axiom
annotated source: apoptotic process
annotated property: definition
annotated target: A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
database_cross_reference: GOC:cjm
database_cross_reference: GOC:dhl
database_cross_reference: GOC:ecd
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:mtg_apoptosis
database_cross_reference: GOC:tb
database_cross_reference: ISBN:0198506732
database_cross_reference: PMID:18846107
database_cross_reference: PMID:21494263

Axiom
annotated source: apoptotic process
annotated property: has_exact_synonym
annotated target: apoptotic cell death
database_cross_reference: GOC:sl

Axiom
annotated source: apoptotic process
annotated property: has_narrow_synonym
annotated target: apoptotic program
database_cross_reference: GOC:add

cellular component disassembly involved in execution phase of apoptosis
type: Class
equivalent class: Class
  intersection of: cellular component disassembly
  intersection of: Restriction
    on property: part of
    some values from: GO_0097194
subclass of: cellular component disassembly
subclass of: Restriction
  on property: part of
  some values from: GO_0097194
definition: The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis.
has_broad_synonym: cellular component disassembly involved in apoptotic process
has_broad_synonym: disassembly of cell structures
has_narrow_synonym: cellular component disassembly involved in apoptosis
has_obo_namespace: biological_process
id: GO:0006921

Axiom
annotated source: cellular component disassembly involved in execution phase of apoptosis
annotated property: definition
annotated target: The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis.
database_cross_reference: GOC:dph
database_cross_reference: GOC:mah
database_cross_reference: GOC:mtg_apoptosis
database_cross_reference: GOC:tb

movement of cell or subcellular component
type: Class
subclass of: cellular process
definition: The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore.
has_exact_synonym: cellular component motion
has_exact_synonym: cellular component movement
has_obo_namespace: biological_process
has_related_synonym: cell movement
id: GO:0006928
in_subset: gocheck do not annotate
in_subset: goslim pir
comment: Note that in GO cellular components include whole cells (cell is_a cellular component).

Axiom
annotated source: movement of cell or subcellular component
annotated property: definition
annotated target: The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore.
database_cross_reference: GOC:dgh
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mlg

Axiom
annotated source: movement of cell or subcellular component
annotated property: has_exact_synonym
annotated target: cellular component motion
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl

response to stress
type: Class
subclass of: GO_0050896
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
has_obo_namespace: biological_process
has_related_synonym: response to abiotic stress
has_related_synonym: response to biotic stress
id: GO:0006950
in_subset: gocheck do not manually annotate
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim plant
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to stress
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
database_cross_reference: GOC:mah

defense response
type: Class
subclass of: response to stress
definition: Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
has_alternative_id: GO:0002217
has_alternative_id: GO:0042829
has_exact_synonym: defence response
has_exact_synonym: physiological defense response
has_obo_namespace: biological_process
has_related_synonym: antimicrobial peptide activity
has_related_synonym: defense/immunity protein activity
id: GO:0006952

Axiom
annotated source: defense response
annotated property: definition
annotated target: Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
database_cross_reference: GOC:go_curators

inflammatory response
type: Class
subclass of: defense response
definition: The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
has_broad_synonym: inflammation
database_cross_reference: Wikipedia:Inflammation
has_obo_namespace: biological_process
id: GO:0006954

Axiom
annotated source: inflammatory response
annotated property: definition
annotated target: The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
database_cross_reference: GO_REF:0000022
database_cross_reference: ISBN:0198506732

immune response
type: Class
subclass of: immune system process
subclass of: GO_0050896
definition: Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
has_obo_namespace: biological_process
id: GO:0006955
in_subset: goslim drosophila

Axiom
annotated source: immune response
annotated property: definition
annotated target: Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
database_cross_reference: GOC:add
database_cross_reference: GO_REF:0000022

cellular defense response
type: Class
subclass of: defense response
definition: A defense response that is mediated by cells.
IAO_0000233: https://github.com/geneontology/go-ontology/issues/18111
has_alternative_id: GO:0002818
has_alternative_id: GO:0016066
has_alternative_id: GO:0016067
has_exact_synonym: cellular defence response
has_narrow_synonym: intracellular defence response
has_narrow_synonym: intracellular defense response
has_obo_namespace: biological_process
id: GO:0006968

Axiom
annotated source: cellular defense response
annotated property: definition
annotated target: A defense response that is mediated by cells.
database_cross_reference: GOC:ebc

response to osmotic stress
type: Class
subclass of: response to stress
subclass of: response to abiotic stimulus
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
has_exact_synonym: osmotic response
has_exact_synonym: osmotic stress response
has_obo_namespace: biological_process
id: GO:0006970
in_subset: goslim yeast

Axiom
annotated source: response to osmotic stress
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
database_cross_reference: GOC:jl

hyperosmotic response
type: Class
subclass of: response to osmotic stress
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.
has_exact_synonym: HOG response
has_exact_synonym: hypertonic response
has_exact_synonym: response to hypertonicity
has_obo_namespace: biological_process
id: GO:0006972

Axiom
annotated source: hyperosmotic response
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.
database_cross_reference: GOC:jl
database_cross_reference: PMID:12142009

Axiom
annotated source: hyperosmotic response
annotated property: has_exact_synonym
annotated target: response to hypertonicity
database_cross_reference: GOC:mah
database_cross_reference: GOC:yaf

cellular response to DNA damage stimulus
type: Class
subclass of: cellular response to stress
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
has_alternative_id: GO:0034984
has_broad_synonym: response to DNA damage stimulus
has_exact_synonym: DNA damage response
has_exact_synonym: cellular DNA damage response
has_exact_synonym: response to genotoxic stress
has_obo_namespace: biological_process
id: GO:0006974
in_subset: goslim yeast

Axiom
annotated source: cellular response to DNA damage stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
database_cross_reference: GOC:go_curators

organelle organization
type: Class
subclass of: cellular component organization
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
created by: jl
creation date: 2013-12-19T15:25:51Z
has_alternative_id: GO:1902589
has_exact_synonym: organelle organisation
has_exact_synonym: single organism organelle organization
has_obo_namespace: biological_process
has_related_synonym: organelle organization and biogenesis
has_related_synonym: single-organism organelle organization
id: GO:0006996
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim pir

Axiom
annotated source: organelle organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
database_cross_reference: GOC:mah

Axiom
annotated source: organelle organization
annotated property: has_exact_synonym
annotated target: single organism organelle organization
database_cross_reference: GOC:TermGenie

Axiom
annotated source: organelle organization
annotated property: has_related_synonym
annotated target: organelle organization and biogenesis
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

nucleus organization
type: Class
subclass of: organelle organization
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus.
has_alternative_id: GO:0048287
has_exact_synonym: nuclear organisation
has_exact_synonym: nuclear organization
has_obo_namespace: biological_process
has_related_synonym: nuclear morphology
has_related_synonym: nuclear organization and biogenesis
has_related_synonym: nucleus organization and biogenesis
id: GO:0006997
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim drosophila
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: nucleus organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus.
database_cross_reference: GOC:dph
database_cross_reference: GOC:ems
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Axiom
annotated source: nucleus organization
annotated property: has_related_synonym
annotated target: nuclear organization and biogenesis
database_cross_reference: GOC:mah

Axiom
annotated source: nucleus organization
annotated property: has_related_synonym
annotated target: nucleus organization and biogenesis
database_cross_reference: GOC:mah

mitochondrion organization
type: Class
subclass of: organelle organization
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
has_exact_synonym: mitochondria organization
has_exact_synonym: mitochondrion organisation
has_obo_namespace: biological_process
has_related_synonym: mitochondrion organization and biogenesis
id: GO:0007005
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim yeast

Axiom
annotated source: mitochondrion organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah
database_cross_reference: GOC:sgd_curators
database_cross_reference: PMID:9786946

Axiom
annotated source: mitochondrion organization
annotated property: has_exact_synonym
annotated target: mitochondria organization
database_cross_reference: GOC:mah

Axiom
annotated source: mitochondrion organization
annotated property: has_exact_synonym
annotated target: mitochondrion organisation
database_cross_reference: GOC:mah

mitochondrial membrane organization
type: Class
equivalent class: Class
  intersection of: GO_0061024
  intersection of: Restriction
    on property: occurs in
    some values from: mitochondrion
subclass of: mitochondrion organization
subclass of: GO_0061024
subclass of: Restriction
  on property: occurs in
  some values from: mitochondrion
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion.
has_exact_synonym: mitochondrial membrane organisation
has_obo_namespace: biological_process
has_related_synonym: mitochondrial membrane organization and biogenesis
id: GO:0007006

Axiom
annotated source: mitochondrial membrane organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion.
database_cross_reference: GOC:ai
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Axiom
annotated source: mitochondrial membrane organization
annotated property: has_related_synonym
annotated target: mitochondrial membrane organization and biogenesis
database_cross_reference: GOC:mah

cytoskeleton organization
type: Class
subclass of: organelle organization
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
has_exact_synonym: cytoskeleton organisation
has_obo_namespace: biological_process
has_related_synonym: cytoskeletal organization and biogenesis
has_related_synonym: cytoskeletal regulator activity
has_related_synonym: cytoskeleton organization and biogenesis
id: GO:0007010
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim yeast

Axiom
annotated source: cytoskeleton organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Axiom
annotated source: cytoskeleton organization
annotated property: has_related_synonym
annotated target: cytoskeletal organization and biogenesis
database_cross_reference: GOC:mah

Axiom
annotated source: cytoskeleton organization
annotated property: has_related_synonym
annotated target: cytoskeleton organization and biogenesis
database_cross_reference: GOC:mah

microtubule-based process
type: Class
subclass of: cellular process
definition: Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.
has_obo_namespace: biological_process
id: GO:0007017
in_subset: goslim chembl

Axiom
annotated source: microtubule-based process
annotated property: definition
annotated target: Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.
database_cross_reference: GOC:mah

microtubule-based movement
type: Class
subclass of: movement of cell or subcellular component
subclass of: microtubule-based process
definition: A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
has_obo_namespace: biological_process
id: GO:0007018

Axiom
annotated source: microtubule-based movement
annotated property: definition
annotated target: A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
database_cross_reference: GOC:cjm
database_cross_reference: ISBN:0815316194

vacuole organization
type: Class
subclass of: organelle organization
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole.
has_alternative_id: GO:0044086
has_exact_synonym: vacuole organisation
has_narrow_synonym: vacuolar assembly
has_obo_namespace: biological_process
has_related_synonym: vacuole biogenesis
has_related_synonym: vacuole organization and biogenesis
id: GO:0007033
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: vacuole organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole.
database_cross_reference: GOC:mah

Axiom
annotated source: vacuole organization
annotated property: has_narrow_synonym
annotated target: vacuolar assembly
database_cross_reference: GOC:mah

Axiom
annotated source: vacuole organization
annotated property: has_related_synonym
annotated target: vacuole biogenesis
database_cross_reference: GOC:mah

Axiom
annotated source: vacuole organization
annotated property: has_related_synonym
annotated target: vacuole organization and biogenesis
database_cross_reference: GOC:mah

vacuolar calcium ion homeostasis
type: Class
equivalent class: Class
  intersection of: GO_0055074
  intersection of: Restriction
    on property: occurs in
    some values from: vacuole
subclass of: cellular calcium ion homeostasis
subclass of: Restriction
  on property: occurs in
  some values from: vacuole
definition: Any process involved in the maintenance of an internal steady state of calcium ions in the vacuole or between a vacuole and its surroundings.
has_obo_namespace: biological_process
id: GO:0007036

Axiom
annotated source: vacuolar calcium ion homeostasis
annotated property: definition
annotated target: Any process involved in the maintenance of an internal steady state of calcium ions in the vacuole or between a vacuole and its surroundings.
database_cross_reference: GOC:ai
database_cross_reference: GOC:mah

cell cycle
type: Class
subclass of: cellular process
definition: The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
database_cross_reference: MIPS_funcat:10
database_cross_reference: MIPS_funcat:10.03
database_cross_reference: Wikipedia:Cell_cycle
has_exact_synonym: cell-division cycle
has_obo_namespace: biological_process
id: GO:0007049
in_subset: gocheck do not manually annotate
in_subset: goslim agr
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant

Axiom
annotated source: cell cycle
annotated property: definition
annotated target: The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:mtg_cell_cycle

spindle organization
type: Class
subclass of: microtubule cytoskeleton organization
subclass of: cell cycle process
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.
has_alternative_id: GO:0043146
has_exact_synonym: spindle organisation
has_obo_namespace: biological_process
has_related_synonym: spindle organization and biogenesis
has_related_synonym: spindle stabilization
id: GO:0007051

Axiom
annotated source: spindle organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:mah

Axiom
annotated source: spindle organization
annotated property: has_related_synonym
annotated target: spindle organization and biogenesis
database_cross_reference: GOC:mah

mitotic spindle organization
type: Class
equivalent class: Class
  intersection of: spindle organization
  intersection of: Restriction
    on property: part of
    some values from: mitotic cell cycle
subclass of: spindle organization
subclass of: GO_1902850
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
IAO_0000233: https://github.com/geneontology/go-ontology/issues/15341
has_alternative_id: GO:0000071
has_alternative_id: GO:0030472
has_alternative_id: GO:0043148
has_exact_synonym: mitotic spindle organisation
has_exact_synonym: spindle organization and biogenesis during mitosis
has_narrow_synonym: mitotic spindle organisation in nucleus
has_narrow_synonym: mitotic spindle organization and biogenesis in cell nucleus
has_narrow_synonym: mitotic spindle organization and biogenesis in nucleus
has_narrow_synonym: mitotic spindle organization in nucleus
has_narrow_synonym: spindle organization and biogenesis in nucleus during mitosis
has_obo_namespace: biological_process
has_related_synonym: mitotic spindle organization and biogenesis
has_related_synonym: mitotic spindle stabilization
id: GO:0007052
comment: In fission yeast most mitotic spindle organization occurs in the nucleus.

Axiom
annotated source: mitotic spindle organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:mah

Axiom
annotated source: mitotic spindle organization
annotated property: has_related_synonym
annotated target: mitotic spindle organization and biogenesis
database_cross_reference: GOC:mah

spindle assembly involved in male meiosis
type: Class
equivalent class: Class
  intersection of: GO_0051225
  intersection of: Restriction
    on property: part of
    some values from: male meiotic nuclear division
subclass of: cellular process involved in reproduction in multicellular organism
subclass of: GO_0090306
subclass of: Restriction
  on property: part of
  some values from: male meiotic nuclear division
definition: The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster.
has_obo_namespace: biological_process
id: GO:0007053

Axiom
annotated source: spindle assembly involved in male meiosis
annotated property: definition
annotated target: The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster.
database_cross_reference: GOC:mah

spindle assembly involved in male meiosis II
type: Class
equivalent class: Class
  intersection of: GO_0051225
  intersection of: Restriction
    on property: part of
    some values from: male meiosis II
subclass of: spindle assembly involved in male meiosis
subclass of: Restriction
  on property: part of
  some values from: male meiosis II
definition: The formation of the spindle during meiosis II of a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster.
has_obo_namespace: biological_process
has_related_synonym: male meiosis II spindle assembly
id: GO:0007055

Axiom
annotated source: spindle assembly involved in male meiosis II
annotated property: definition
annotated target: The formation of the spindle during meiosis II of a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster.
database_cross_reference: GOC:mah

spindle assembly involved in female meiosis
type: Class
equivalent class: Class
  intersection of: GO_0051225
  intersection of: Restriction
    on property: part of
    some values from: female meiotic nuclear division
subclass of: cellular process involved in reproduction in multicellular organism
subclass of: GO_0090306
subclass of: Restriction
  on property: part of
  some values from: female meiotic nuclear division
definition: The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster.
has_obo_namespace: biological_process
has_related_synonym: female meiotic spindle assembly
id: GO:0007056

Axiom
annotated source: spindle assembly involved in female meiosis
annotated property: definition
annotated target: The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster.
database_cross_reference: GOC:mah

spindle assembly involved in female meiosis II
type: Class
equivalent class: Class
  intersection of: GO_0051225
  intersection of: Restriction
    on property: part of
    some values from: female meiosis II
subclass of: spindle assembly involved in female meiosis
subclass of: Restriction
  on property: part of
  some values from: female meiosis II
definition: The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis II of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster.
has_obo_namespace: biological_process
has_related_synonym: female meiosis II spindle assembly
id: GO:0007058

Axiom
annotated source: spindle assembly involved in female meiosis II
annotated property: definition
annotated target: The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis II of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster.
database_cross_reference: GOC:mah

chromosome segregation
type: Class
subclass of: cellular process
definition: The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
database_cross_reference: Wikipedia:Chromosome_segregation
has_exact_synonym: chromosome division
has_obo_namespace: biological_process
has_related_synonym: chromosome transmission
id: GO:0007059
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: chromosome segregation
annotated property: definition
annotated target: The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah
database_cross_reference: GOC:mtg_cell_cycle
database_cross_reference: GOC:vw

mitotic chromosome condensation
type: Class
equivalent class: Class
  intersection of: chromosome condensation
  intersection of: Restriction
    on property: part of
    some values from: mitotic cell cycle
subclass of: chromosome condensation
subclass of: GO_1903047
subclass of: Restriction
  on property: part of
  some values from: mitotic sister chromatid segregation
definition: The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.
has_obo_namespace: biological_process
id: GO:0007076

Axiom
annotated source: mitotic chromosome condensation
annotated property: definition
annotated target: The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0815316194

regulation of mitotic nuclear division
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: GO_0140014
subclass of: regulation of mitotic cell cycle
subclass of: regulation of cell cycle process
subclass of: GO_0051783
subclass of: Restriction
  on property: regulates
  some values from: GO_0140014
definition: Any process that modulates the frequency, rate or extent of mitosis.
has_exact_synonym: regulation of mitosis
has_obo_namespace: biological_process
id: GO:0007088

Axiom
annotated source: regulation of mitotic nuclear division
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of mitosis.
database_cross_reference: GOC:go_curators

meiotic prophase I
type: Class
subclass of: GO_0051324
subclass of: GO_0098764
definition: The cell cycle phase which is the first stage of meiosis I and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.
has_obo_namespace: biological_process
id: GO:0007128
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: meiotic prophase I
annotated property: definition
annotated target: The cell cycle phase which is the first stage of meiosis I and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.
database_cross_reference: GOC:mtg_cell_cycle

meiotic metaphase I
type: Class
subclass of: GO_0051323
subclass of: GO_0098764
definition: The cell cycle phase, following prophase I, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis I.
has_obo_namespace: biological_process
id: GO:0007132
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: meiotic metaphase I
annotated property: definition
annotated target: The cell cycle phase, following prophase I, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis I.
database_cross_reference: GOC:mtg_cell_cycle

meiotic anaphase I
type: Class
subclass of: GO_0051322
subclass of: GO_0098764
definition: The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis I.
has_obo_namespace: biological_process
id: GO:0007133
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: meiotic anaphase I
annotated property: definition
annotated target: The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis I.
database_cross_reference: GOC:mtg_cell_cycle

meiotic telophase I
type: Class
subclass of: GO_0051326
subclass of: GO_0098764
definition: The cell cycle phase which follows anaphase I of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts.
has_obo_namespace: biological_process
id: GO:0007134
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: meiotic telophase I
annotated property: definition
annotated target: The cell cycle phase which follows anaphase I of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts.
database_cross_reference: GOC:mtg_cell_cycle

meiosis II
type: Class
subclass of: GO_0061983
subclass of: GO_0140013
definition: The second nuclear division of meiosis, in which the two chromatids in each chromosome are separated, resulting in four daughter nuclei from the two nuclei produced in meiosis II.
database_cross_reference: Wikipedia:Meiosis#Meiosis_II
has_exact_synonym: meiosis II nuclear division
has_obo_namespace: biological_process
id: GO:0007135

Axiom
annotated source: meiosis II
annotated property: definition
annotated target: The second nuclear division of meiosis, in which the two chromatids in each chromosome are separated, resulting in four daughter nuclei from the two nuclei produced in meiosis II.
database_cross_reference: GOC:dph
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0198547684

meiotic prophase II
type: Class
subclass of: GO_0051324
subclass of: GO_0098765
definition: The cell cycle phase which is the first stage of meiosis II and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.
has_obo_namespace: biological_process
id: GO:0007136
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: meiotic prophase II
annotated property: definition
annotated target: The cell cycle phase which is the first stage of meiosis II and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.
database_cross_reference: GOC:mtg_cell_cycle

meiotic metaphase II
type: Class
subclass of: GO_0051323
subclass of: GO_0098765
definition: The cell cycle phase, following prophase II, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis II.
has_obo_namespace: biological_process
id: GO:0007137
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: meiotic metaphase II
annotated property: definition
annotated target: The cell cycle phase, following prophase II, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis II.
database_cross_reference: GOC:mtg_cell_cycle

meiotic anaphase II
type: Class
subclass of: GO_0051322
subclass of: GO_0098765
definition: The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis II.
has_obo_namespace: biological_process
id: GO:0007138
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: meiotic anaphase II
annotated property: definition
annotated target: The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis II.
database_cross_reference: GOC:mtg_cell_cycle

meiotic telophase II
type: Class
subclass of: GO_0051326
subclass of: GO_0098765
definition: The cell cycle phase which follows anaphase II of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts.
has_obo_namespace: biological_process
id: GO:0007139
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: meiotic telophase II
annotated property: definition
annotated target: The cell cycle phase which follows anaphase II of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts.
database_cross_reference: GOC:mtg_cell_cycle

male meiotic nuclear division
type: Class
equivalent class: Class
  intersection of: nuclear division
  intersection of: Restriction
    on property: part of
    some values from: male gamete generation
  intersection of: Restriction
    on property: part of
    some values from: GO_0051321
subclass of: cellular process involved in reproduction in multicellular organism
subclass of: GO_0140013
subclass of: Restriction
  on property: part of
  some values from: male gamete generation
definition: A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline.
never in taxon: NCBITaxon 4751
has_broad_synonym: male nuclear division
has_obo_namespace: biological_process
has_related_synonym: male meiosis
id: GO:0007140

Axiom
annotated source: male meiotic nuclear division
annotated property: definition
annotated target: A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline.
database_cross_reference: GOC:dph
database_cross_reference: GOC:mah
database_cross_reference: GOC:vw

male meiosis II
type: Class
equivalent class: Class
  intersection of: meiosis II
  intersection of: Restriction
    on property: part of
    some values from: male gamete generation
  intersection of: Restriction
    on property: part of
    some values from: GO_0051321
subclass of: meiosis II
subclass of: male meiotic nuclear division
definition: A cell cycle process comprising the steps by which a cell progresses through male meiosis II, the second meiotic division in the male germline.
has_exact_synonym: male meiosis II nuclear division
has_obo_namespace: biological_process
id: GO:0007142

Axiom
annotated source: male meiosis II
annotated property: definition
annotated target: A cell cycle process comprising the steps by which a cell progresses through male meiosis II, the second meiotic division in the male germline.
database_cross_reference: GOC:dph
database_cross_reference: GOC:mah

female meiotic nuclear division
type: Class
equivalent class: Class
  intersection of: nuclear division
  intersection of: Restriction
    on property: part of
    some values from: female gamete generation
  intersection of: Restriction
    on property: part of
    some values from: GO_0051321
subclass of: cellular process involved in reproduction in multicellular organism
subclass of: GO_0140013
subclass of: Restriction
  on property: part of
  some values from: female gamete generation
definition: A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline.
never in taxon: NCBITaxon 4751
has_broad_synonym: female meiosis
has_broad_synonym: female meiotic division
has_obo_namespace: biological_process
id: GO:0007143
comment: Note that female germ lines can be found in female or hermaphroditic organisms, so this term can be used to annotate gene products from hermaphrodites such as those of C. elegans. See also the biological process term 'meiotic nuclear division; GO:0140013'.

Axiom
annotated source: female meiotic nuclear division
annotated property: definition
annotated target: A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline.
database_cross_reference: GOC:dph
database_cross_reference: GOC:ems
database_cross_reference: GOC:mah
database_cross_reference: GOC:vw

female meiosis II
type: Class
equivalent class: Class
  intersection of: meiosis II
  intersection of: Restriction
    on property: part of
    some values from: female gamete generation
  intersection of: Restriction
    on property: part of
    some values from: GO_0051321
subclass of: meiosis II
subclass of: female meiotic nuclear division
definition: The cell cycle process in which the second meiotic division occurs in the female germline.
has_exact_synonym: female meiosis II nuclear division
has_obo_namespace: biological_process
id: GO:0007147

Axiom
annotated source: female meiosis II
annotated property: definition
annotated target: The cell cycle process in which the second meiotic division occurs in the female germline.
database_cross_reference: GOC:mah

cell communication
type: Class
subclass of: cellular process
definition: Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
database_cross_reference: Wikipedia:Cell_signaling
has_obo_namespace: biological_process
id: GO:0007154
in_subset: goslim pir
in_subset: goslim plant

Axiom
annotated source: cell communication
annotated property: definition
annotated target: Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
database_cross_reference: GOC:mah

cell adhesion
type: Class
subclass of: cellular process
subclass of: biological adhesion
definition: The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
created by: davidos
creation date: 2014-04-15T15:59:10Z
has_alternative_id: GO:0098602
database_cross_reference: Wikipedia:Cell_adhesion
has_obo_namespace: biological_process
has_related_synonym: cell adhesion molecule activity
has_related_synonym: single organism cell adhesion
id: GO:0007155
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim pombe

Axiom
annotated source: cell adhesion
annotated property: definition
annotated target: The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
database_cross_reference: GOC:hb
database_cross_reference: GOC:pf

negative regulation of cell adhesion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cell adhesion
subclass of: regulation of cell adhesion
subclass of: negative regulation of cellular process
subclass of: Restriction
  on property: negatively regulates
  some values from: cell adhesion
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
has_exact_synonym: down regulation of cell adhesion
has_exact_synonym: down-regulation of cell adhesion
has_exact_synonym: downregulation of cell adhesion
has_narrow_synonym: inhibition of cell adhesion
has_obo_namespace: biological_process
has_related_synonym: cell adhesion receptor inhibitor activity
id: GO:0007162

Axiom
annotated source: negative regulation of cell adhesion
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
database_cross_reference: GOC:go_curators

signal transduction
type: Class
subclass of: cellular process
subclass of: GO_0050794
subclass of: Restriction
  on property: part of
  some values from: cell communication
subclass of: Restriction
  on property: part of
  some values from: signaling
subclass of: Restriction
  on property: part of
  some values from: GO_0051716
definition: The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
has_alternative_id: GO:0023033
database_cross_reference: MIPS_funcat:30
database_cross_reference: Wikipedia:Signal_transduction
has_narrow_synonym: signaling cascade
has_narrow_synonym: signalling cascade
has_obo_namespace: biological_process
has_related_synonym: signaling pathway
has_related_synonym: signalling pathway
id: GO:0007165
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim plant
comment: Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not.

Axiom
annotated source: signal transduction
annotated property: definition
annotated target: The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:mtg_signaling_feb11

Axiom
annotated source: signal transduction
annotated property: has_related_synonym
annotated target: signalling pathway
database_cross_reference: GOC:mah

G protein-coupled receptor signaling pathway
type: Class
subclass of: signal transduction
definition: A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
has_alternative_id: GO:0038042
has_exact_synonym: G protein coupled receptor protein signaling pathway
has_exact_synonym: G protein coupled receptor protein signalling pathway
has_exact_synonym: G-protein coupled receptor protein signal transduction
has_exact_synonym: G-protein coupled receptor protein signaling pathway
has_exact_synonym: G-protein coupled receptor signalling pathway
has_exact_synonym: G-protein-coupled receptor protein signalling pathway
has_exact_synonym: GPCR signaling pathway
has_exact_synonym: GPCR signalling pathway
has_narrow_synonym: G-protein coupled receptor signaling pathway via GPCR dimer
has_narrow_synonym: dimeric G-protein coupled receptor signaling pathway
has_narrow_synonym: dimeric G-protein coupled receptor signalling pathway
has_obo_namespace: biological_process
id: GO:0007186
in_subset: goslim drosophila

Axiom
annotated source: G protein-coupled receptor signaling pathway
annotated property: definition
annotated target: A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
database_cross_reference: GOC:bf
database_cross_reference: GOC:mah
database_cross_reference: PMID:16902576
database_cross_reference: PMID:24568158
database_cross_reference: Wikipedia:G_protein-coupled_receptor

Axiom
annotated source: G protein-coupled receptor signaling pathway
annotated property: has_exact_synonym
annotated target: G-protein coupled receptor protein signaling pathway
database_cross_reference: GOC:bf

Axiom
annotated source: G protein-coupled receptor signaling pathway
annotated property: has_narrow_synonym
annotated target: G-protein coupled receptor signaling pathway via GPCR dimer
database_cross_reference: GOC:bf

Axiom
annotated source: G protein-coupled receptor signaling pathway
annotated property: has_narrow_synonym
annotated target: dimeric G-protein coupled receptor signalling pathway
database_cross_reference: GOC:mah

cell-cell signaling
type: Class
subclass of: cell communication
subclass of: signaling
definition: Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
has_exact_synonym: cell-cell signalling
has_obo_namespace: biological_process
id: GO:0007267
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim plant

Axiom
annotated source: cell-cell signaling
annotated property: definition
annotated target: Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
database_cross_reference: GOC:dos
database_cross_reference: GOC:mah

multicellular organism development
type: Class
subclass of: multicellular organismal process
subclass of: anatomical structure development
definition: The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
database_cross_reference: MIPS_funcat:41
has_obo_namespace: biological_process
id: GO:0007275
in_subset: goslim chembl
in_subset: goslim plant
comment: Note that this term was 'developmental process'.

Axiom
annotated source: multicellular organism development
annotated property: definition
annotated target: The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
database_cross_reference: GOC:dph
database_cross_reference: GOC:ems
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:tb

gamete generation
type: Class
subclass of: multicellular organismal reproductive process
subclass of: Restriction
  on property: part of
  some values from: sexual reproduction
definition: The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.
never in taxon: NCBITaxon Union 0000023
has_alternative_id: GO:0009552
has_obo_namespace: biological_process
has_related_synonym: gametogenesis
id: GO:0007276

Axiom
annotated source: gamete generation
annotated property: definition
annotated target: The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.
database_cross_reference: GOC:ems
database_cross_reference: GOC:mtg_sensu

germ cell development
type: Class
subclass of: developmental process involved in reproduction
subclass of: cellular process involved in reproduction in multicellular organism
subclass of: cell development
subclass of: Restriction
  on property: part of
  some values from: gamete generation
definition: The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
has_exact_synonym: germ-cell development
has_narrow_synonym: primordial germ cell development
has_obo_namespace: biological_process
id: GO:0007281

Axiom
annotated source: germ cell development
annotated property: definition
annotated target: The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
database_cross_reference: GOC:go_curators

spermatogenesis
type: Class
subclass of: developmental process involved in reproduction
subclass of: male gamete generation
definition: The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.
database_cross_reference: Wikipedia:Spermatogenesis
has_exact_synonym: generation of spermatozoa
has_obo_namespace: biological_process
id: GO:0007283

Axiom
annotated source: spermatogenesis
annotated property: definition
annotated target: The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.
database_cross_reference: GOC:jid
database_cross_reference: ISBN:9780878933846
database_cross_reference: PMID:28073824
database_cross_reference: PMID:30990821

Axiom
annotated source: spermatogenesis
annotated property: has_exact_synonym
annotated target: generation of spermatozoa
has_synonym_type: Systematic synonym

spermatid development
type: Class
subclass of: germ cell development
subclass of: Restriction
  on property: part of
  some values from: spermatid differentiation
definition: The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.
database_cross_reference: Wikipedia:Spermiogenesis
has_exact_synonym: spermatid cell development
has_exact_synonym: spermiogenesis
has_obo_namespace: biological_process
id: GO:0007286

Axiom
annotated source: spermatid development
annotated property: definition
annotated target: The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.
database_cross_reference: GOC:dph
database_cross_reference: GOC:go_curators

sperm axoneme assembly
type: Class
subclass of: developmental process involved in reproduction
subclass of: cellular process involved in reproduction in multicellular organism
subclass of: axoneme assembly
subclass of: Restriction
  on property: part of
  some values from: spermatid development
subclass of: Restriction
  on property: part of
  some values from: flagellated sperm motility
definition: The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement.
has_obo_namespace: biological_process
id: GO:0007288

Axiom
annotated source: sperm axoneme assembly
annotated property: definition
annotated target: The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement.
database_cross_reference: GOC:bf
database_cross_reference: GOC:cilia
database_cross_reference: ISBN:0198547684

spermatid nucleus differentiation
type: Class
subclass of: nucleus organization
subclass of: cellular process involved in reproduction in multicellular organism
subclass of: Restriction
  on property: part of
  some values from: spermatid development
definition: The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization.
has_exact_synonym: spermatid nuclear differentiation
has_obo_namespace: biological_process
id: GO:0007289
comment: See also the Cell Ontology term 'spermatid ; CL:0000018'.

Axiom
annotated source: spermatid nucleus differentiation
annotated property: definition
annotated target: The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization.
database_cross_reference: GOC:bf
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

female gamete generation
type: Class
subclass of: gamete generation
definition: Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction.
has_obo_namespace: biological_process
id: GO:0007292

Axiom
annotated source: female gamete generation
annotated property: definition
annotated target: Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction.
database_cross_reference: GOC:dph
database_cross_reference: ISBN:0198506732

single fertilization
type: Class
subclass of: fertilization
definition: The union of male and female gametes to form a zygote.
never in taxon: NCBITaxon_58024
database_cross_reference: MIPS_funcat:41.05.01
has_obo_namespace: biological_process
has_related_synonym: zygote biosynthesis
has_related_synonym: zygote formation
id: GO:0007338

Axiom
annotated source: single fertilization
annotated property: definition
annotated target: The union of male and female gametes to form a zygote.
database_cross_reference: GOC:ems
database_cross_reference: GOC:mtg_sensu

regulation of mitotic cell cycle
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: mitotic cell cycle
subclass of: GO_0051726
subclass of: Restriction
  on property: regulates
  some values from: mitotic cell cycle
definition: Any process that modulates the rate or extent of progress through the mitotic cell cycle.
has_exact_synonym: mitotic cell cycle modulation
has_exact_synonym: mitotic cell cycle regulation
has_exact_synonym: modulation of mitotic cell cycle progression
has_exact_synonym: regulation of mitotic cell cycle progression
has_exact_synonym: regulation of progression through mitotic cell cycle
has_obo_namespace: biological_process
has_related_synonym: mitotic cell cycle regulator
id: GO:0007346

Axiom
annotated source: regulation of mitotic cell cycle
annotated property: definition
annotated target: Any process that modulates the rate or extent of progress through the mitotic cell cycle.
database_cross_reference: GOC:dph
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:tb

Axiom
annotated source: regulation of mitotic cell cycle
annotated property: has_exact_synonym
annotated target: regulation of progression through mitotic cell cycle
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

nervous system development
type: Class
subclass of: system development
definition: The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
has_obo_namespace: biological_process
has_related_synonym: pan-neural process
id: GO:0007399
in_subset: goslim drosophila

Axiom
annotated source: nervous system development
annotated property: definition
annotated target: The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
database_cross_reference: GOC:dgh

central nervous system development
type: Class
subclass of: system development
subclass of: Restriction
  on property: part of
  some values from: nervous system development
definition: The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
database_cross_reference: Wikipedia:Neural_development
has_exact_synonym: CNS development
has_obo_namespace: biological_process
id: GO:0007417

Axiom
annotated source: central nervous system development
annotated property: definition
annotated target: The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
database_cross_reference: GOC:bf
database_cross_reference: GOC:jid
database_cross_reference: ISBN:0582227089

brain development
type: Class
subclass of: animal organ development
subclass of: Restriction
  on property: part of
  some values from: central nervous system development
subclass of: Restriction
  on property: part of
  some values from: GO_0060322
definition: The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
has_obo_namespace: biological_process
id: GO:0007420

Axiom
annotated source: brain development
annotated property: definition
annotated target: The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
database_cross_reference: GOC:dph
database_cross_reference: GOC:jid
database_cross_reference: GOC:tb
database_cross_reference: UBERON:0000955

aging
type: Class
subclass of: developmental process
definition: A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
has_alternative_id: GO:0016280
database_cross_reference: Wikipedia:Aging
has_exact_synonym: ageing
has_obo_namespace: biological_process
id: GO:0007568
in_subset: goslim chembl
in_subset: goslim generic

Axiom
annotated source: aging
annotated property: definition
annotated target: A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
database_cross_reference: GOC:PO_curators

response to nutrient
type: Class
subclass of: response to nutrient levels
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
has_exact_synonym: response to nutrients
has_narrow_synonym: nutritional response pathway
has_obo_namespace: biological_process
id: GO:0007584

Axiom
annotated source: response to nutrient
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
database_cross_reference: GOC:go_curators

excretion
type: Class
subclass of: system process
definition: The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.
database_cross_reference: Wikipedia:Excretion
has_obo_namespace: biological_process
id: GO:0007588
in_subset: goslim pir

Axiom
annotated source: excretion
annotated property: definition
annotated target: The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.
database_cross_reference: ISBN:0192801023

blood coagulation
type: Class
subclass of: hemostasis
subclass of: GO_0050817
subclass of: Restriction
  on property: part of
  some values from: wound healing
definition: The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
database_cross_reference: Wikipedia:Coagulation
has_exact_synonym: blood clotting
has_obo_namespace: biological_process
id: GO:0007596

Axiom
annotated source: blood coagulation
annotated property: definition
annotated target: The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
database_cross_reference: ISBN:0198506732
database_cross_reference: http://www.graylab.ac.uk/omd/

hemostasis
type: Class
subclass of: GO_0050878
definition: The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part.
database_cross_reference: Wikipedia:Hemostasis
has_obo_namespace: biological_process
id: GO:0007599

Axiom
annotated source: hemostasis
annotated property: definition
annotated target: The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part.
database_cross_reference: ISBN:0198506732

sensory perception
type: Class
subclass of: GO_0050877
definition: The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
database_cross_reference: Wikipedia:Perception
has_obo_namespace: biological_process
id: GO:0007600
in_subset: goslim drosophila

Axiom
annotated source: sensory perception
annotated property: definition
annotated target: The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
database_cross_reference: GOC:ai
database_cross_reference: GOC:dph

visual perception
type: Class
subclass of: GO_0050953
definition: The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
database_cross_reference: Wikipedia:Visual_perception
has_exact_synonym: sense of sight
has_exact_synonym: sensory visual perception
has_exact_synonym: vision
has_obo_namespace: biological_process
id: GO:0007601

Axiom
annotated source: visual perception
annotated property: definition
annotated target: The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
database_cross_reference: GOC:ai

phototransduction
type: Class
subclass of: signal transduction
subclass of: detection of light stimulus
definition: The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.
database_cross_reference: Wikipedia:Visual_phototransduction
has_narrow_synonym: phototransduction, visible light, light adaptation
has_narrow_synonym: phototrophin mediated phototransduction
has_obo_namespace: biological_process
has_related_synonym: opsin
id: GO:0007602

Axiom
annotated source: phototransduction
annotated property: definition
annotated target: The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.
database_cross_reference: GOC:go_curators

phototransduction, visible light
type: Class
subclass of: phototransduction
subclass of: detection of visible light
definition: The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm.
has_exact_synonym: visual cascade
has_exact_synonym: visual transduction
has_obo_namespace: biological_process
id: GO:0007603

Axiom
annotated source: phototransduction, visible light
annotated property: definition
annotated target: The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732

Axiom
annotated source: phototransduction, visible light
annotated property: has_exact_synonym
annotated target: visual cascade
database_cross_reference: PMID:1962207
database_cross_reference: PMID:9822721

Axiom
annotated source: phototransduction, visible light
annotated property: has_exact_synonym
annotated target: visual transduction
database_cross_reference: PMID:10611962

phototransduction, UV
type: Class
subclass of: phototransduction
subclass of: detection of UV
subclass of: cellular response to UV
definition: The sequence of reactions within a cell required to convert absorbed photons from UV light into a molecular signal; ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 400 nanometers.
has_exact_synonym: phototransduction, UV light
has_exact_synonym: phototransduction, UV radiation
has_exact_synonym: phototransduction, ultraviolet light
has_exact_synonym: phototransduction, ultraviolet radiation
has_obo_namespace: biological_process
has_related_synonym: UV-sensitive opsin
id: GO:0007604

Axiom
annotated source: phototransduction, UV
annotated property: definition
annotated target: The sequence of reactions within a cell required to convert absorbed photons from UV light into a molecular signal; ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 400 nanometers.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732

sensory perception of sound
type: Class
subclass of: GO_0050954
definition: The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
database_cross_reference: Wikipedia:Hearing_(sense)
has_exact_synonym: hearing
has_exact_synonym: perception of sound
has_obo_namespace: biological_process
id: GO:0007605

Axiom
annotated source: sensory perception of sound
annotated property: definition
annotated target: The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
database_cross_reference: GOC:ai

sensory perception of chemical stimulus
type: Class
subclass of: sensory perception
definition: The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
has_exact_synonym: chemosensory perception
has_obo_namespace: biological_process
id: GO:0007606

Axiom
annotated source: sensory perception of chemical stimulus
annotated property: definition
annotated target: The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
database_cross_reference: GOC:ai

sensory perception of smell
type: Class
subclass of: sensory perception of chemical stimulus
definition: The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.
database_cross_reference: Wikipedia:Olfaction
has_exact_synonym: olfaction
has_exact_synonym: scent perception
has_exact_synonym: sense of smell
has_exact_synonym: smell perception
has_obo_namespace: biological_process
id: GO:0007608

Axiom
annotated source: sensory perception of smell
annotated property: definition
annotated target: The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.
database_cross_reference: GOC:ai

behavior
type: Class
subclass of: GO_0050896
disjoint with: developmental process
definition: The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.
created by: janelomax
creation date: 2012-09-20T14:06:08Z
has_alternative_id: GO:0023032
has_alternative_id: GO:0044708
has_alternative_id: GO:0044709
database_cross_reference: Wikipedia:Behavior
has_exact_synonym: behavioral response to stimulus
has_exact_synonym: behaviour
has_exact_synonym: behavioural response to stimulus
has_obo_namespace: biological_process
has_related_synonym: single-organism behavior
id: GO:0007610
in_subset: gocheck do not manually annotate
in_subset: goslim agr
in_subset: goslim flybase ribbon
comment: 1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews. 2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis).

Axiom
annotated source: behavior
annotated property: definition
annotated target: The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.
database_cross_reference: GOC:ems
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0395448956
database_cross_reference: PMID:20160973

learning or memory
type: Class
subclass of: behavior
subclass of: GO_0050890
definition: The acquisition and processing of information and/or the storage and retrieval of this information over time.
has_obo_namespace: biological_process
id: GO:0007611

Axiom
annotated source: learning or memory
annotated property: definition
annotated target: The acquisition and processing of information and/or the storage and retrieval of this information over time.
database_cross_reference: GOC:jid
database_cross_reference: PMID:8938125

learning
type: Class
subclass of: learning or memory
definition: Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
database_cross_reference: Wikipedia:Learning
has_obo_namespace: biological_process
id: GO:0007612

Axiom
annotated source: learning
annotated property: definition
annotated target: Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
database_cross_reference: ISBN:0582227089
database_cross_reference: ISBN:0721662544

memory
type: Class
subclass of: learning or memory
definition: The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
database_cross_reference: Wikipedia:Memory
has_obo_namespace: biological_process
id: GO:0007613

Axiom
annotated source: memory
annotated property: definition
annotated target: The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
database_cross_reference: GOC:curators
database_cross_reference: ISBN:0582227089

short-term memory
type: Class
subclass of: memory
definition: The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation.
database_cross_reference: Wikipedia:Short-term_memory
has_obo_namespace: biological_process
id: GO:0007614

Axiom
annotated source: short-term memory
annotated property: definition
annotated target: The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation.
database_cross_reference: ISBN:0582227089
database_cross_reference: http://hebb.mit.edu/courses/9.03/lecture4.html

long-term memory
type: Class
subclass of: memory
definition: The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
database_cross_reference: Wikipedia:Long-term_memory
has_obo_namespace: biological_process
id: GO:0007616

Axiom
annotated source: long-term memory
annotated property: definition
annotated target: The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
database_cross_reference: ISBN:0582227089
database_cross_reference: http://hebb.mit.edu/courses/9.03/lecture4.html

mating behavior
type: Class
equivalent class: Class
  intersection of: behavior
  intersection of: Restriction
    on property: part of
    some values from: mating
subclass of: reproductive behavior
subclass of: Restriction
  on property: part of
  some values from: mating
definition: The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes.
database_cross_reference: Wikipedia:Mating_behaviour
has_exact_synonym: mating behaviour
has_obo_namespace: biological_process
id: GO:0007617

Axiom
annotated source: mating behavior
annotated property: definition
annotated target: The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes.
database_cross_reference: GOC:ai
database_cross_reference: GOC:dph

mating
type: Class
subclass of: multi-organism reproductive process
subclass of: Restriction
  on property: part of
  some values from: sexual reproduction
definition: The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes.
has_obo_namespace: biological_process
id: GO:0007618

Axiom
annotated source: mating
annotated property: definition
annotated target: The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0387520546

copulation
type: Class
subclass of: mating
definition: The act of sexual union between male and female, involving the transfer of sperm.
has_obo_namespace: biological_process
id: GO:0007620

Axiom
annotated source: copulation
annotated property: definition
annotated target: The act of sexual union between male and female, involving the transfer of sperm.
database_cross_reference: ISBN:0721662544

rhythmic behavior
type: Class
subclass of: behavior
subclass of: rhythmic process
definition: The specific behavior of an organism that recur with measured regularity.
has_exact_synonym: rhythmic behavioral response to stimulus
has_exact_synonym: rhythmic behaviour
has_exact_synonym: rhythmic behavioural response to stimulus
has_obo_namespace: biological_process
id: GO:0007622

Axiom
annotated source: rhythmic behavior
annotated property: definition
annotated target: The specific behavior of an organism that recur with measured regularity.
database_cross_reference: GOC:jl
database_cross_reference: GOC:pr

circadian rhythm
type: Class
subclass of: rhythmic process
definition: Any biological process in an organism that recurs with a regularity of approximately 24 hours.
has_alternative_id: GO:0050895
database_cross_reference: Wikipedia:Circadian_rhythm
has_exact_synonym: circadian process
has_obo_namespace: biological_process
has_related_synonym: circadian response
has_related_synonym: response to circadian rhythm
id: GO:0007623
in_subset: goslim drosophila
in_subset: goslim plant

Axiom
annotated source: circadian rhythm
annotated property: definition
annotated target: Any biological process in an organism that recurs with a regularity of approximately 24 hours.
database_cross_reference: GOC:bf
database_cross_reference: GOC:go_curators

locomotory behavior
type: Class
subclass of: behavior
definition: The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
has_exact_synonym: behavior via locomotion
has_exact_synonym: locomotion in response to stimulus
has_exact_synonym: locomotory behavioral response to stimulus
has_exact_synonym: locomotory behaviour
has_exact_synonym: locomotory behavioural response to stimulus
has_obo_namespace: biological_process
id: GO:0007626
in_subset: goslim drosophila

Axiom
annotated source: locomotory behavior
annotated property: definition
annotated target: The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
database_cross_reference: GOC:dph

feeding behavior
type: Class
subclass of: behavior
definition: Behavior associated with the intake of food.
IAO_0000233: https://github.com/geneontology/go-ontology/issues/18547
created by: janelomax
creation date: 2011-10-27T03:53:33Z
has_alternative_id: GO:0044366
has_alternative_id: GO:0044367
has_alternative_id: GO:0044368
has_alternative_id: GO:0044369
has_alternative_id: GO:0044370
has_alternative_id: GO:0044371
has_alternative_id: GO:0044372
database_cross_reference: Wikipedia:List_of_feeding_behaviours
has_exact_synonym: behavioral response to food
has_exact_synonym: behavioural response to food
has_exact_synonym: feeding behaviour
has_narrow_synonym: eating
has_narrow_synonym: feeding from phloem of other organism
has_narrow_synonym: feeding from plant phloem
has_narrow_synonym: feeding from tissue of other organism
has_narrow_synonym: feeding from vascular tissue of another organism
has_narrow_synonym: feeding from xylem of other organism
has_narrow_synonym: feeding on blood of other organism
has_narrow_synonym: feeding on or from other organism
has_narrow_synonym: feeding on plant sap
has_narrow_synonym: hematophagy
has_narrow_synonym: injection of substance into other organism during feeding on blood of other organism
has_narrow_synonym: taking of blood meal
has_obo_namespace: biological_process
id: GO:0007631
comment: See also the biological process term 'behavior ; GO:0007610'.

Axiom
annotated source: feeding behavior
annotated property: definition
annotated target: Behavior associated with the intake of food.
database_cross_reference: GOC:mah

visual behavior
type: Class
subclass of: behavior
subclass of: response to light stimulus
subclass of: multicellular organismal process
definition: The behavior of an organism in response to a visual stimulus.
has_exact_synonym: behavioral response to visual stimulus
has_exact_synonym: behavioural response to visual stimulus
has_exact_synonym: visual behaviour
has_obo_namespace: biological_process
id: GO:0007632

Axiom
annotated source: visual behavior
annotated property: definition
annotated target: The behavior of an organism in response to a visual stimulus.
database_cross_reference: GOC:jid
database_cross_reference: GOC:pr

chemosensory behavior
type: Class
subclass of: behavior
subclass of: Restriction
  on property: part of
  some values from: response to chemical
definition: Behavior that is dependent upon the sensation of chemicals.
has_exact_synonym: behavioral response to chemical stimulus
has_exact_synonym: behavioural response to chemical stimulus
has_exact_synonym: chemosensory behaviour
has_obo_namespace: biological_process
id: GO:0007635

Axiom
annotated source: chemosensory behavior
annotated property: definition
annotated target: Behavior that is dependent upon the sensation of chemicals.
database_cross_reference: GOC:go_curators

protein localization
type: Class
subclass of: macromolecule localization
definition: Any process in which a protein is transported to, or maintained in, a specific location.
has_alternative_id: GO:0008105
has_exact_synonym: protein localisation
has_obo_namespace: biological_process
has_related_synonym: asymmetric protein localisation
has_related_synonym: asymmetric protein localization
has_related_synonym: establishment and maintenance of asymmetric protein localization
has_related_synonym: establishment and maintenance of protein localization
id: GO:0008104

Axiom
annotated source: protein localization
annotated property: definition
annotated target: Any process in which a protein is transported to, or maintained in, a specific location.
database_cross_reference: GOC:ai

Axiom
annotated source: protein localization
annotated property: has_exact_synonym
annotated target: protein localisation
database_cross_reference: GOC:mah

Axiom
annotated source: protein localization
annotated property: has_related_synonym
annotated target: asymmetric protein localisation
database_cross_reference: GOC:mah

transcription factor binding
type: Class
subclass of: protein binding
definition: Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
has_exact_synonym: TF binding
has_obo_namespace: molecular_function
id: GO:0008134
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim yeast

Axiom
annotated source: transcription factor binding
annotated property: definition
annotated target: Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
database_cross_reference: ISBN:0198506732

biological_process
type: Class
subclass of: process
definition: A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
created by: janelomax
creation date: 2012-09-19T15:05:24Z
has_alternative_id: GO:0000004
has_alternative_id: GO:0007582
has_alternative_id: GO:0044699
database_cross_reference: Wikipedia:Biological_process
has_exact_synonym: biological process
has_exact_synonym: physiological process
has_obo_namespace: biological_process
has_related_synonym: single organism process
has_related_synonym: single-organism process
id: GO:0008150
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim pombe
in_subset: goslim yeast
comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code "no data" (ND), is used to indicate this.

Axiom
annotated source: biological_process
annotated property: definition
annotated target: A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
database_cross_reference: GOC:pdt

metabolic process
type: Class
subclass of: biological_process
disjoint with: biological phase
definition: The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
created by: janelomax
creation date: 2012-10-17T15:46:40Z
has_alternative_id: GO:0044236
has_alternative_id: GO:0044710
database_cross_reference: MIPS_funcat:01
database_cross_reference: Wikipedia:Metabolism
has_exact_synonym: metabolism
has_narrow_synonym: metabolic process resulting in cell growth
has_narrow_synonym: metabolism resulting in cell growth
has_narrow_synonym: multicellular organism metabolic process
has_obo_namespace: biological_process
has_related_synonym: single-organism metabolic process
id: GO:0008152
in_subset: gocheck do not manually annotate
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions.

Axiom
annotated source: metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198547684

cell death
type: Class
subclass of: cellular process
definition: Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
has_obo_namespace: biological_process
has_related_synonym: accidental cell death
has_related_synonym: necrosis
id: GO:0008219
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant
comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term.

Axiom
annotated source: cell death
annotated property: definition
annotated target: Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
database_cross_reference: GOC:mah
database_cross_reference: GOC:mtg_apoptosis
database_cross_reference: PMID:25236395

peptidase activity
type: Class
subclass of: hydrolase activity
subclass of: GO_0140096
subclass of: Restriction
  on property: part of
  some values from: proteolysis
definition: Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
database_cross_reference: EC:3.4
database_cross_reference: Reactome:R-HSA-205112
database_cross_reference: Reactome:R-HSA-3000243
database_cross_reference: Reactome:R-HSA-3139027
database_cross_reference: Reactome:R-HSA-376149
database_cross_reference: Reactome:R-HSA-448678
database_cross_reference: Reactome:R-HSA-5655483
database_cross_reference: Reactome:R-HSA-5684864
database_cross_reference: Reactome:R-HSA-5685902
database_cross_reference: Reactome:R-HSA-5693319
has_exact_synonym: hydrolase, acting on peptide bonds
has_exact_synonym: peptide hydrolase activity
has_exact_synonym: protease activity
has_narrow_synonym: proteinase activity
has_obo_namespace: molecular_function
id: GO:0008233
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: peptidase activity
annotated property: definition
annotated target: Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0815332181

gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-205112

Unknown protease degrades GIF:Cbl to release Cbl
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3000243

Maturation of HIV Virion
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3139027

Proteolytic processing of SLIT
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-376149

CTSG cleaves CASP1(1-404)
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-448678

USP1 autocleavage
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5655483

NAPSA, CTSH, PGA3-5 cleave pro-SFTPB
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5684864

NAPSA, CTSH, PGA3-5 cleave pro-SFTPC
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5685902

CTRC hydrolyses PRSS1
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5693319

cysteine-type peptidase activity
type: Class
subclass of: GO_0070011
definition: Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
has_alternative_id: GO:0004220
database_cross_reference: Reactome:R-HSA-2022381
database_cross_reference: Reactome:R-HSA-2467775
database_cross_reference: Reactome:R-HSA-2467809
database_cross_reference: Reactome:R-HSA-5660752
has_narrow_synonym: cysteine protease activity
has_narrow_synonym: thiol protease activity
has_obo_namespace: molecular_function
id: GO:0008234

Axiom
annotated source: cysteine-type peptidase activity
annotated property: definition
annotated target: Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
database_cross_reference: GOC:mah
database_cross_reference: http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE

Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)
type: Axiom
annotated source: cysteine-type peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2022381

Autocleavage of ESPL1 (Separase)
type: Axiom
annotated source: cysteine-type peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2467775

ESPL1 (Separase) cleaves centromeric cohesin
type: Axiom
annotated source: cysteine-type peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2467809

USP9X deubiquitinates Ub-SNCA
type: Axiom
annotated source: cysteine-type peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5660752

regulation of G protein-coupled receptor signaling pathway
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: G protein-coupled receptor signaling pathway
subclass of: regulation of signal transduction
subclass of: Restriction
  on property: regulates
  some values from: G protein-coupled receptor signaling pathway
definition: Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.
has_exact_synonym: regulation of G protein coupled receptor protein signaling pathway
has_exact_synonym: regulation of G protein coupled receptor protein signalling pathway
has_exact_synonym: regulation of G-protein coupled receptor protein signaling pathway
has_exact_synonym: regulation of G-protein coupled receptor protein signalling pathway
has_exact_synonym: regulation of G-protein-coupled receptor protein signalling pathway
has_exact_synonym: regulation of GPCR protein signaling pathway
has_exact_synonym: regulation of GPCR protein signalling pathway
has_obo_namespace: biological_process
id: GO:0008277

Axiom
annotated source: regulation of G protein-coupled receptor signaling pathway
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.
database_cross_reference: GOC:go_curators

cell population proliferation
type: Class
subclass of: cellular process
definition: The multiplication or reproduction of cells, resulting in the expansion of a cell population.
never in taxon: NCBITaxon 4751
has_obo_namespace: biological_process
has_related_synonym: cell proliferation
id: GO:0008283
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
comment: This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms.

Axiom
annotated source: cell population proliferation
annotated property: definition
annotated target: The multiplication or reproduction of cells, resulting in the expansion of a cell population.
database_cross_reference: GOC:mah
database_cross_reference: GOC:mb

positive regulation of cell population proliferation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: cell population proliferation
subclass of: regulation of cell population proliferation
subclass of: positive regulation of cellular process
subclass of: Restriction
  on property: positively regulates
  some values from: cell population proliferation
definition: Any process that activates or increases the rate or extent of cell proliferation.
never in taxon: NCBITaxon 4751
has_exact_synonym: up regulation of cell proliferation
has_exact_synonym: up-regulation of cell proliferation
has_exact_synonym: upregulation of cell proliferation
has_narrow_synonym: activation of cell proliferation
has_narrow_synonym: stimulation of cell proliferation
has_obo_namespace: biological_process
has_related_synonym: positive regulation of cell proliferation
id: GO:0008284

Axiom
annotated source: positive regulation of cell population proliferation
annotated property: definition
annotated target: Any process that activates or increases the rate or extent of cell proliferation.
database_cross_reference: GOC:go_curators

negative regulation of cell population proliferation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cell population proliferation
subclass of: regulation of cell population proliferation
subclass of: negative regulation of cellular process
subclass of: Restriction
  on property: negatively regulates
  some values from: cell population proliferation
definition: Any process that stops, prevents or reduces the rate or extent of cell proliferation.
never in taxon: NCBITaxon 4751
has_exact_synonym: down regulation of cell proliferation
has_exact_synonym: down-regulation of cell proliferation
has_exact_synonym: downregulation of cell proliferation
has_narrow_synonym: inhibition of cell proliferation
has_obo_namespace: biological_process
has_related_synonym: negative regulation of cell proliferation
id: GO:0008285

Axiom
annotated source: negative regulation of cell population proliferation
annotated property: definition
annotated target: Any process that stops, prevents or reduces the rate or extent of cell proliferation.
database_cross_reference: GOC:go_curators

DNA binding, bending
type: Class
subclass of: DNA binding
definition: The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.
has_exact_synonym: DNA bending activity
has_exact_synonym: DNA bending involving DNA binding
has_obo_namespace: molecular_function
id: GO:0008301

Axiom
annotated source: DNA binding, bending
annotated property: definition
annotated target: The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.
database_cross_reference: GOC:krc
database_cross_reference: GOC:vw
database_cross_reference: PMID:10710711
database_cross_reference: PMID:19037758

associative learning
type: Class
subclass of: learning
definition: Learning by associating a stimulus (the cause) with a particular outcome (the effect).
database_cross_reference: Wikipedia:Learning#Associative_learning
has_exact_synonym: Pavlovian conditioning
has_exact_synonym: classical conditioning
has_exact_synonym: conditional learning
has_exact_synonym: conditional response
has_obo_namespace: biological_process
id: GO:0008306

Axiom
annotated source: associative learning
annotated property: definition
annotated target: Learning by associating a stimulus (the cause) with a particular outcome (the effect).
database_cross_reference: ISBN:0582227089

olfactory learning
type: Class
subclass of: associative learning
subclass of: olfactory behavior
definition: Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue.
has_obo_namespace: biological_process
id: GO:0008355

Axiom
annotated source: olfactory learning
annotated property: definition
annotated target: Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue.
database_cross_reference: ISBN:0582227089

asymmetric cell division
type: Class
subclass of: GO_0051301
definition: The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity.
database_cross_reference: Wikipedia:Asymmetric_cell_division
has_exact_synonym: asymmetrical cell division
has_obo_namespace: biological_process
has_related_synonym: asymmetric cytokinesis
has_related_synonym: asymmetrical cytokinesis
id: GO:0008356

Axiom
annotated source: asymmetric cell division
annotated property: definition
annotated target: The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity.
database_cross_reference: PMID:11672519

anion transmembrane transporter activity
type: Class
subclass of: ion transmembrane transporter activity
subclass of: Restriction
  on property: part of
  some values from: GO_0098656
definition: Enables the transfer of a negatively charged ion from one side of a membrane to the other.
database_cross_reference: Reactome:R-HSA-166214
has_exact_synonym: anion transporter activity
has_obo_namespace: molecular_function
id: GO:0008509

Axiom
annotated source: anion transmembrane transporter activity
annotated property: definition
annotated target: Enables the transfer of a negatively charged ion from one side of a membrane to the other.
database_cross_reference: GOC:dgf
database_cross_reference: GOC:mtg_transport
database_cross_reference: ISBN:0815340729

FA anion flip-flops to the opposite surface
type: Axiom
annotated source: anion transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-166214

organic anion transmembrane transporter activity
type: Class
subclass of: anion transmembrane transporter activity
subclass of: Restriction
  on property: part of
  some values from: organic anion transport
definition: Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.
database_cross_reference: Reactome:R-HSA-2142859
has_obo_namespace: molecular_function
id: GO:0008514

Axiom
annotated source: organic anion transmembrane transporter activity
annotated property: definition
annotated target: Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.
database_cross_reference: GOC:ai

Growing HA is extruded from the cell by ABCC5
type: Axiom
annotated source: organic anion transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2142859

folic acid transmembrane transporter activity
type: Class
subclass of: dicarboxylic acid transmembrane transporter activity
subclass of: amide transmembrane transporter activity
subclass of: GO_0072349
subclass of: GO_0090482
subclass of: Restriction
  on property: part of
  some values from: folic acid transport
definition: Enables the transfer of folic acid (pteroylglutamic acid) from one side of a membrane to the other. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
database_cross_reference: Reactome:R-HSA-200646
database_cross_reference: Reactome:R-HSA-200652
database_cross_reference: Reactome:R-HSA-200680
database_cross_reference: Reactome:R-HSA-200720
database_cross_reference: Reactome:R-HSA-200729
has_exact_synonym: folate transmembrane transporter activity
has_exact_synonym: folate transporter activity
has_exact_synonym: vitamin B9 transporter activity
has_exact_synonym: vitamin M transporter activity
has_obo_namespace: molecular_function
has_related_synonym: folic acid transporter activity
id: GO:0008517

Axiom
annotated source: folic acid transmembrane transporter activity
annotated property: definition
annotated target: Enables the transfer of folic acid (pteroylglutamic acid) from one side of a membrane to the other. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
database_cross_reference: GOC:ai

Cytosolic folate export across the plasma membrane
type: Axiom
annotated source: folic acid transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-200646

Extracellular 5-methyltetrahydrofolate import across the plasma membrane
type: Axiom
annotated source: folic acid transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-200652

Cytosolic tetrahydrofolate import across the inner mitochondrial membrane
type: Axiom
annotated source: folic acid transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-200680

Mitochondrial tetrahydrofolate export across the inner mitochondrial membrane
type: Axiom
annotated source: folic acid transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-200720

Extracellular folate import across the plasma membrane
type: Axiom
annotated source: folic acid transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-200729

visual learning
type: Class
subclass of: visual behavior
subclass of: associative learning
definition: Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.
has_obo_namespace: biological_process
has_related_synonym: spatial learning
id: GO:0008542

Axiom
annotated source: visual learning
annotated property: definition
annotated target: Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.
database_cross_reference: GOC:jid
database_cross_reference: ISBN:0582227089

ubiquitin-like modifier activating enzyme activity
type: Class
subclass of: ligase activity, forming carbon-sulfur bonds
definition: Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond.
IAO_0000233: https://github.com/geneontology/go-ontology/issues/14208
has_alternative_id: GO:0008642
has_narrow_synonym: small protein activating enzyme activity
has_obo_namespace: molecular_function
id: GO:0008641
in_subset: goslim pir

Axiom
annotated source: ubiquitin-like modifier activating enzyme activity
annotated property: definition
annotated target: Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

catabolic process
type: Class
subclass of: metabolic process
definition: The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
created by: janelomax
creation date: 2012-10-17T15:52:35Z
has_alternative_id: GO:0044243
has_alternative_id: GO:0044712
database_cross_reference: Wikipedia:Catabolism
has_exact_synonym: breakdown
has_exact_synonym: catabolism
has_exact_synonym: degradation
has_narrow_synonym: multicellular organismal catabolic process
has_obo_namespace: biological_process
has_related_synonym: single-organism catabolic process
id: GO:0009056
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim plant

Axiom
annotated source: catabolic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
database_cross_reference: ISBN:0198547684

biosynthetic process
type: Class
subclass of: metabolic process
definition: The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
created by: janelomax
creation date: 2012-10-17T15:52:18Z
has_alternative_id: GO:0044274
has_alternative_id: GO:0044711
has_broad_synonym: formation
database_cross_reference: Wikipedia:Anabolism
has_exact_synonym: anabolism
has_exact_synonym: biosynthesis
has_exact_synonym: synthesis
has_narrow_synonym: multicellular organismal biosynthetic process
has_obo_namespace: biological_process
has_related_synonym: single-organism biosynthetic process
id: GO:0009058
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim plant

Axiom
annotated source: biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
database_cross_reference: GOC:curators
database_cross_reference: ISBN:0198547684

macromolecule biosynthetic process
type: Class
subclass of: macromolecule metabolic process
subclass of: GO_1901576
definition: The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
has_alternative_id: GO:0043284
has_exact_synonym: biopolymer biosynthetic process
has_exact_synonym: macromolecule anabolism
has_exact_synonym: macromolecule biosynthesis
has_exact_synonym: macromolecule formation
has_exact_synonym: macromolecule synthesis
has_obo_namespace: biological_process
id: GO:0009059
in_subset: goslim pir

Axiom
annotated source: macromolecule biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
database_cross_reference: GOC:mah

Axiom
annotated source: macromolecule biosynthetic process
annotated property: has_exact_synonym
annotated target: biopolymer biosynthetic process
database_cross_reference: GOC:mtg_chebi_dec09

glycoprotein metabolic process
type: Class
subclass of: protein metabolic process
subclass of: cellular macromolecule metabolic process
subclass of: GO_1901135
definition: The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
has_exact_synonym: glycoprotein metabolism
has_obo_namespace: biological_process
id: GO:0009100
in_subset: goslim drosophila

Axiom
annotated source: glycoprotein metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732

glycoprotein biosynthetic process
type: Class
subclass of: glycoprotein metabolic process
subclass of: cellular macromolecule biosynthetic process
subclass of: GO_1901137
subclass of: GO_1901566
definition: The chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
has_exact_synonym: glycoprotein anabolism
has_exact_synonym: glycoprotein biosynthesis
has_exact_synonym: glycoprotein formation
has_exact_synonym: glycoprotein synthesis
has_obo_namespace: biological_process
id: GO:0009101

Axiom
annotated source: glycoprotein biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732

nucleoside metabolic process
type: Class
subclass of: GO_0055086
subclass of: GO_1901564
subclass of: GO_1901657
definition: The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine).
has_exact_synonym: nucleoside metabolism
has_obo_namespace: biological_process
id: GO:0009116
in_subset: goslim pir

Axiom
annotated source: nucleoside metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine).
database_cross_reference: GOC:ma

nucleotide metabolic process
type: Class
subclass of: nucleoside phosphate metabolic process
definition: The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates).
has_exact_synonym: nucleotide metabolism
has_obo_namespace: biological_process
id: GO:0009117
in_subset: goslim pir

Axiom
annotated source: nucleotide metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates).
database_cross_reference: GOC:ma

regulation of nucleoside metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: nucleoside metabolic process
subclass of: regulation of nucleobase-containing compound metabolic process
subclass of: GO_0062012
subclass of: Restriction
  on property: regulates
  some values from: nucleoside metabolic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleosides.
has_exact_synonym: regulation of nucleoside metabolism
has_obo_namespace: biological_process
id: GO:0009118

Axiom
annotated source: regulation of nucleoside metabolic process
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleosides.
database_cross_reference: GOC:go_curators

ribonucleoside metabolic process
type: Class
subclass of: nucleoside metabolic process
definition: The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule.
has_exact_synonym: ribonucleoside metabolism
has_obo_namespace: biological_process
id: GO:0009119

Axiom
annotated source: ribonucleoside metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule.
database_cross_reference: GOC:jl

nucleoside monophosphate metabolic process
type: Class
subclass of: nucleoside phosphate metabolic process
definition: The chemical reactions and pathways involving a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar.
has_exact_synonym: nucleoside monophosphate metabolism
has_obo_namespace: biological_process
id: GO:0009123

Axiom
annotated source: nucleoside monophosphate metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732

nucleoside monophosphate biosynthetic process
type: Class
subclass of: nucleoside monophosphate metabolic process
subclass of: GO_1901293
definition: The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar.
has_exact_synonym: nucleoside monophosphate anabolism
has_exact_synonym: nucleoside monophosphate biosynthesis
has_exact_synonym: nucleoside monophosphate formation
has_exact_synonym: nucleoside monophosphate synthesis
has_obo_namespace: biological_process
id: GO:0009124

Axiom
annotated source: nucleoside monophosphate biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732

purine nucleoside monophosphate metabolic process
type: Class
subclass of: nucleoside monophosphate metabolic process
definition: The chemical reactions and pathways involving purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar.
has_exact_synonym: purine nucleoside monophosphate metabolism
has_obo_namespace: biological_process
id: GO:0009126

Axiom
annotated source: purine nucleoside monophosphate metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732

purine nucleoside monophosphate biosynthetic process
type: Class
subclass of: nucleoside monophosphate biosynthetic process
subclass of: purine nucleoside monophosphate metabolic process
definition: The chemical reactions and pathways resulting in the formation of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar.
has_exact_synonym: purine nucleoside monophosphate anabolism
has_exact_synonym: purine nucleoside monophosphate biosynthesis
has_exact_synonym: purine nucleoside monophosphate formation
has_exact_synonym: purine nucleoside monophosphate synthesis
has_obo_namespace: biological_process
id: GO:0009127

Axiom
annotated source: purine nucleoside monophosphate biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732

nucleoside triphosphate metabolic process
type: Class
subclass of: nucleoside phosphate metabolic process
definition: The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar.
has_exact_synonym: nucleoside triphosphate metabolism
has_obo_namespace: biological_process
id: GO:0009141

Axiom
annotated source: nucleoside triphosphate metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732

nucleoside triphosphate biosynthetic process
type: Class
subclass of: nucleoside triphosphate metabolic process
subclass of: GO_1901293
definition: The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar.
has_exact_synonym: nucleoside triphosphate anabolism
has_exact_synonym: nucleoside triphosphate biosynthesis
has_exact_synonym: nucleoside triphosphate formation
has_exact_synonym: nucleoside triphosphate synthesis
has_obo_namespace: biological_process
id: GO:0009142

Axiom
annotated source: nucleoside triphosphate biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732

purine nucleoside triphosphate metabolic process
type: Class
subclass of: nucleoside triphosphate metabolic process
definition: The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar.
has_exact_synonym: purine nucleoside triphosphate metabolism
has_obo_namespace: biological_process
id: GO:0009144

Axiom
annotated source: purine nucleoside triphosphate metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732

purine nucleoside triphosphate biosynthetic process
type: Class
subclass of: nucleoside triphosphate biosynthetic process
subclass of: purine nucleoside triphosphate metabolic process
definition: The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar.
has_exact_synonym: purine nucleoside triphosphate anabolism
has_exact_synonym: purine nucleoside triphosphate biosynthesis
has_exact_synonym: purine nucleoside triphosphate formation
has_exact_synonym: purine nucleoside triphosphate synthesis
has_obo_namespace: biological_process
id: GO:0009145

Axiom
annotated source: purine nucleoside triphosphate biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732

purine ribonucleotide metabolic process
type: Class
subclass of: purine nucleotide metabolic process
subclass of: ribonucleotide metabolic process
definition: The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
has_exact_synonym: purine ribonucleotide metabolism
has_obo_namespace: biological_process
id: GO:0009150

Axiom
annotated source: purine ribonucleotide metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732

purine ribonucleotide biosynthetic process
type: Class
subclass of: purine nucleotide biosynthetic process
subclass of: purine ribonucleotide metabolic process
subclass of: ribonucleotide biosynthetic process
definition: The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
has_exact_synonym: purine ribonucleotide anabolism
has_exact_synonym: purine ribonucleotide biosynthesis
has_exact_synonym: purine ribonucleotide formation
has_exact_synonym: purine ribonucleotide synthesis
has_obo_namespace: biological_process
id: GO:0009152

Axiom
annotated source: purine ribonucleotide biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732

ribonucleoside monophosphate biosynthetic process
type: Class
subclass of: nucleoside monophosphate biosynthetic process
subclass of: ribonucleoside monophosphate metabolic process
definition: The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar.
has_exact_synonym: ribonucleoside monophosphate anabolism
has_exact_synonym: ribonucleoside monophosphate biosynthesis
has_exact_synonym: ribonucleoside monophosphate formation
has_exact_synonym: ribonucleoside monophosphate synthesis
has_obo_namespace: biological_process
id: GO:0009156

Axiom
annotated source: ribonucleoside monophosphate biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732

ribonucleoside monophosphate metabolic process
type: Class
subclass of: nucleoside monophosphate metabolic process
definition: The chemical reactions and pathways involving a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar.
has_exact_synonym: ribonucleoside monophosphate metabolism
has_obo_namespace: biological_process
id: GO:0009161

Axiom
annotated source: ribonucleoside monophosphate metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732

nucleoside biosynthetic process
type: Class
subclass of: nucleoside metabolic process
subclass of: nucleobase-containing small molecule biosynthetic process
subclass of: GO_1901566
subclass of: GO_1901659
definition: The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).
has_exact_synonym: nucleoside anabolism
has_exact_synonym: nucleoside biosynthesis
has_exact_synonym: nucleoside formation
has_exact_synonym: nucleoside synthesis
has_obo_namespace: biological_process
id: GO:0009163

Axiom
annotated source: nucleoside biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0140512713

nucleotide biosynthetic process
type: Class
subclass of: nucleotide metabolic process
subclass of: GO_1901293
definition: The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).
has_exact_synonym: nucleotide anabolism
has_exact_synonym: nucleotide biosynthesis
has_exact_synonym: nucleotide formation
has_exact_synonym: nucleotide synthesis
has_obo_namespace: biological_process
id: GO:0009165

Axiom
annotated source: nucleotide biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).
database_cross_reference: GOC:go_curators

purine ribonucleoside monophosphate metabolic process
type: Class
subclass of: purine nucleoside monophosphate metabolic process
subclass of: ribonucleoside monophosphate metabolic process
definition: The chemical reactions and pathways involving purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar.
has_exact_synonym: purine ribonucleoside monophosphate metabolism
has_obo_namespace: biological_process
id: GO:0009167

Axiom
annotated source: purine ribonucleoside monophosphate metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732

purine ribonucleoside monophosphate biosynthetic process
type: Class
subclass of: purine nucleoside monophosphate biosynthetic process
subclass of: ribonucleoside monophosphate biosynthetic process
subclass of: purine ribonucleoside monophosphate metabolic process
definition: The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar.
has_exact_synonym: purine ribonucleoside monophosphate anabolism
has_exact_synonym: purine ribonucleoside monophosphate biosynthesis
has_exact_synonym: purine ribonucleoside monophosphate formation
has_exact_synonym: purine ribonucleoside monophosphate synthesis
has_obo_namespace: biological_process
id: GO:0009168

Axiom
annotated source: purine ribonucleoside monophosphate biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732

ribonucleoside triphosphate metabolic process
type: Class
subclass of: nucleoside triphosphate metabolic process
definition: The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar.
has_exact_synonym: ribonucleoside triphosphate metabolism
has_obo_namespace: biological_process
id: GO:0009199

Axiom
annotated source: ribonucleoside triphosphate metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732

ribonucleoside triphosphate biosynthetic process
type: Class
subclass of: nucleoside triphosphate biosynthetic process
subclass of: ribonucleoside triphosphate metabolic process
definition: The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar.
has_exact_synonym: ribonucleoside triphosphate anabolism
has_exact_synonym: ribonucleoside triphosphate biosynthesis
has_exact_synonym: ribonucleoside triphosphate formation
has_exact_synonym: ribonucleoside triphosphate synthesis
has_obo_namespace: biological_process
id: GO:0009201

Axiom
annotated source: ribonucleoside triphosphate biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732

purine ribonucleoside triphosphate metabolic process
type: Class
subclass of: purine nucleoside triphosphate metabolic process
subclass of: ribonucleoside triphosphate metabolic process
definition: The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar.
has_exact_synonym: purine ribonucleoside triphosphate metabolism
has_obo_namespace: biological_process
id: GO:0009205

Axiom
annotated source: purine ribonucleoside triphosphate metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732

purine ribonucleoside triphosphate biosynthetic process
type: Class
subclass of: purine nucleoside triphosphate biosynthetic process
subclass of: ribonucleoside triphosphate biosynthetic process
subclass of: purine ribonucleoside triphosphate metabolic process
definition: The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar.
has_exact_synonym: purine ribonucleoside triphosphate anabolism
has_exact_synonym: purine ribonucleoside triphosphate biosynthesis
has_exact_synonym: purine ribonucleoside triphosphate formation
has_exact_synonym: purine ribonucleoside triphosphate synthesis
has_obo_namespace: biological_process
id: GO:0009206

Axiom
annotated source: purine ribonucleoside triphosphate biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732

cobalamin metabolic process
type: Class
subclass of: water-soluble vitamin metabolic process
subclass of: drug metabolic process
subclass of: tetrapyrrole metabolic process
subclass of: GO_0051186
definition: The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
has_exact_synonym: cobalamin metabolism
has_exact_synonym: vitamin B12 metabolic process
has_exact_synonym: vitamin B12 metabolism
has_narrow_synonym: vitamin B12 reduction
has_obo_namespace: biological_process
id: GO:0009235

Axiom
annotated source: cobalamin metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
database_cross_reference: GOC:go_curators

ribonucleotide metabolic process
type: Class
subclass of: nucleotide metabolic process
subclass of: ribose phosphate metabolic process
definition: The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
has_alternative_id: GO:0009121
has_exact_synonym: ribonucleotide metabolism
has_obo_namespace: biological_process
id: GO:0009259

Axiom
annotated source: ribonucleotide metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732

ribonucleotide biosynthetic process
type: Class
subclass of: nucleotide biosynthetic process
subclass of: ribonucleotide metabolic process
subclass of: ribose phosphate biosynthetic process
definition: The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
has_exact_synonym: ribonucleotide anabolism
has_exact_synonym: ribonucleotide biosynthesis
has_exact_synonym: ribonucleotide formation
has_exact_synonym: ribonucleotide synthesis
has_obo_namespace: biological_process
id: GO:0009260

Axiom
annotated source: ribonucleotide biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732

response to temperature stimulus
type: Class
subclass of: response to abiotic stimulus
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.
has_exact_synonym: response to thermal stimulus
has_obo_namespace: biological_process
id: GO:0009266

Axiom
annotated source: response to temperature stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.
database_cross_reference: GOC:hb

cellular response to starvation
type: Class
subclass of: cellular response to nutrient levels
subclass of: cellular response to stress
subclass of: response to starvation
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
has_obo_namespace: biological_process
id: GO:0009267

Axiom
annotated source: cellular response to starvation
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
database_cross_reference: GOC:jl

response to pH
type: Class
subclass of: response to abiotic stimulus
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
has_obo_namespace: biological_process
id: GO:0009268

Axiom
annotated source: response to pH
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
database_cross_reference: GOC:jl
database_cross_reference: Wikipedia:PH

fungal-type cell wall
type: Class
subclass of: cell wall
definition: A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis, consisting of extensively cross-linked glycoproteins and carbohydrates. The glycoproteins may be modified with N- or O-linked carbohydrates, or glycosylphosphatidylinositol (GPI) anchors; the polysaccharides are primarily branched glucans, including beta-linked and alpha-linked glucans, and may also include chitin and other carbohydrate polymers, but not cellulose or pectin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure.
has_narrow_synonym: chitin- and beta-glucan-containing cell wall
has_obo_namespace: cellular_component
has_related_synonym: beta-glucan-containing cell wall
has_related_synonym: chitin-containing cell wall
id: GO:0009277

Axiom
annotated source: fungal-type cell wall
annotated property: definition
annotated target: A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis, consisting of extensively cross-linked glycoproteins and carbohydrates. The glycoproteins may be modified with N- or O-linked carbohydrates, or glycosylphosphatidylinositol (GPI) anchors; the polysaccharides are primarily branched glucans, including beta-linked and alpha-linked glucans, and may also include chitin and other carbohydrate polymers, but not cellulose or pectin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure.
database_cross_reference: GOC:mcc
database_cross_reference: GOC:mtg_sensu
database_cross_reference: ISBN:3540601864
database_cross_reference: PMID:11283274
database_cross_reference: PMID:16927300
database_cross_reference: PMID:3319422

cell outer membrane
type: Class
equivalent class: Class
  intersection of: outer membrane
  intersection of: Restriction
    on property: part of
    some values from: cell envelope
subclass of: outer membrane
subclass of: Restriction
  on property: part of
  some values from: external encapsulating structure
subclass of: Restriction
  on property: part of
  some values from: cell envelope
definition: A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
has_exact_synonym: outer membrane of cell
has_obo_namespace: cellular_component
id: GO:0009279
comment: To annotate the plasma (cytoplasmic) membrane, see instead GO:0005886.

Axiom
annotated source: cell outer membrane
annotated property: definition
annotated target: A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
database_cross_reference: GOC:md
database_cross_reference: GOC:mtg_sensu
database_cross_reference: ISBN:0135712254

nucleoid
type: Class
subclass of: GO_0110165
definition: The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined.
database_cross_reference: Wikipedia:Nucleoid
has_obo_namespace: cellular_component
id: GO:0009295

Axiom
annotated source: nucleoid
annotated property: definition
annotated target: The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined.
database_cross_reference: GOC:bm
database_cross_reference: GOC:ma
database_cross_reference: ISBN:3540076689

protein secretion
type: Class
subclass of: peptide secretion
subclass of: protein transport
subclass of: secretion by cell
subclass of: establishment of protein localization to extracellular region
definition: The controlled release of proteins from a cell.
has_alternative_id: GO:0045166
has_alternative_id: GO:0045731
has_narrow_synonym: glycoprotein secretion
has_narrow_synonym: protein secretion during cell fate commitment
has_narrow_synonym: protein secretion resulting in cell fate commitment
has_obo_namespace: biological_process
id: GO:0009306
in_subset: goslim drosophila

Axiom
annotated source: protein secretion
annotated property: definition
annotated target: The controlled release of proteins from a cell.
database_cross_reference: GOC:ai

response to radiation
type: Class
subclass of: response to abiotic stimulus
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.
has_exact_synonym: response to electromagnetic radiation stimulus
has_exact_synonym: response to radiation stimulus
has_obo_namespace: biological_process
id: GO:0009314
comment: Note that 'radiation' refers to electromagnetic radiation of any wavelength.

Axiom
annotated source: response to radiation
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.
database_cross_reference: GOC:jl
database_cross_reference: Wikipedia:Electromagnetic_radiation

quorum sensing
type: Class
subclass of: cell-cell signaling
subclass of: multi-organism cellular process
subclass of: GO_0060245
definition: The cell-cell signaling process in which single-celled organisms carry out coordinated responses by monitoring their own population density, and often also that of other microbes, by producing small, diffusible, signal molecules, detecting the concentration of these molecules, and triggering a signal transduction pathway when a certain threshold is reached. Quorum sensing can occur amongst microbial communities in the environment or within host organisms.
has_alternative_id: GO:0010699
has_alternative_id: GO:0060247
database_cross_reference: Wikipedia:Quorum_sensing
has_exact_synonym: quorum sensing system
has_obo_namespace: biological_process
has_related_synonym: cell-cell signaling involved in quorum sensing
has_related_synonym: detection of cell density by secreted molecule
id: GO:0009372
in_subset: goslim metagenomics
in_subset: goslim pir

Axiom
annotated source: quorum sensing
annotated property: definition
annotated target: The cell-cell signaling process in which single-celled organisms carry out coordinated responses by monitoring their own population density, and often also that of other microbes, by producing small, diffusible, signal molecules, detecting the concentration of these molecules, and triggering a signal transduction pathway when a certain threshold is reached. Quorum sensing can occur amongst microbial communities in the environment or within host organisms.
database_cross_reference: GOC:krc
database_cross_reference: GOC:mlg
database_cross_reference: PMID:10607620
database_cross_reference: PMID:15716452
database_cross_reference: PMID:16497924
database_cross_reference: PMID:16630813
database_cross_reference: PMID:8288518

response to heat
type: Class
subclass of: response to stress
subclass of: response to temperature stimulus
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
has_alternative_id: GO:0006951
has_narrow_synonym: response to heat shock
has_obo_namespace: biological_process
id: GO:0009408
in_subset: goslim yeast

Axiom
annotated source: response to heat
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
database_cross_reference: GOC:lr

response to cold
type: Class
subclass of: response to stress
subclass of: response to temperature stimulus
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
has_obo_namespace: biological_process
has_related_synonym: freezing tolerance
id: GO:0009409

Axiom
annotated source: response to cold
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
database_cross_reference: GOC:lr

response to xenobiotic stimulus
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.
has_alternative_id: GO:0017104
has_obo_namespace: biological_process
id: GO:0009410

Axiom
annotated source: response to xenobiotic stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.
database_cross_reference: GOC:jl

response to UV
type: Class
subclass of: response to light stimulus
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
has_exact_synonym: response to UV light stimulus
has_exact_synonym: response to UV radiation stimulus
has_exact_synonym: response to ultraviolet light stimulus
has_exact_synonym: response to ultraviolet radiation stimulus
has_obo_namespace: biological_process
id: GO:0009411

Axiom
annotated source: response to UV
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
database_cross_reference: GOC:hb

response to water deprivation
type: Class
subclass of: response to stress
subclass of: response to water
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
has_exact_synonym: response to dehydration
has_exact_synonym: response to drought
has_exact_synonym: response to thirst
has_obo_namespace: biological_process
has_related_synonym: drought tolerance
id: GO:0009414

Axiom
annotated source: response to water deprivation
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
database_cross_reference: GOC:lr

response to water
type: Class
subclass of: response to acid chemical
subclass of: response to abiotic stimulus
subclass of: response to inorganic substance
subclass of: GO_1901700
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water.
has_exact_synonym: response to water stimulus
has_obo_namespace: biological_process
id: GO:0009415

Axiom
annotated source: response to water
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water.
database_cross_reference: GOC:jl

Axiom
annotated source: response to water
annotated property: has_exact_synonym
annotated target: response to water stimulus
database_cross_reference: GOC:dos

response to light stimulus
type: Class
subclass of: response to radiation
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
has_obo_namespace: biological_process
id: GO:0009416
in_subset: goslim plant

Axiom
annotated source: response to light stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0582227089

energy taxis
type: Class
subclass of: taxis
definition: The directed movement of a motile cell or organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates.
has_exact_synonym: energytaxis
has_exact_synonym: taxis in response to energy source
has_obo_namespace: biological_process
id: GO:0009453

Axiom
annotated source: energy taxis
annotated property: definition
annotated target: The directed movement of a motile cell or organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates.
database_cross_reference: GOC:jl
database_cross_reference: PMID:11029423

chloroplast
type: Class
subclass of: plastid
definition: A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
never in taxon: NCBITaxon_28009
never in taxon: NCBITaxon_33208
never in taxon: NCBITaxon 4751
never in taxon: NCBITaxon_554915
database_cross_reference: Wikipedia:Chloroplast
has_obo_namespace: cellular_component
id: GO:0009507
in_subset: goslim plant

Axiom
annotated source: chloroplast
annotated property: definition
annotated target: A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
database_cross_reference: ISBN:0471245208

plastid envelope
type: Class
subclass of: organelle envelope
subclass of: Restriction
  on property: part of
  some values from: plastid
definition: The double lipid bilayer enclosing a plastid and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
has_obo_namespace: cellular_component
id: GO:0009526

Axiom
annotated source: plastid envelope
annotated property: definition
annotated target: The double lipid bilayer enclosing a plastid and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
database_cross_reference: GOC:jy

plastid stroma
type: Class
subclass of: GO_0110165
subclass of: Restriction
  on property: part of
  some values from: plastid
definition: The proteinaceous ground substance of plastids.
has_obo_namespace: cellular_component
id: GO:0009532

Axiom
annotated source: plastid stroma
annotated property: definition
annotated target: The proteinaceous ground substance of plastids.
database_cross_reference: ISBN:0943088399

chloroplast stromal thylakoid
type: Class
equivalent class: Class
  intersection of: chloroplast thylakoid
  intersection of: Restriction
    on property: part of
    some values from: chloroplast stroma
subclass of: chloroplast thylakoid
subclass of: Restriction
  on property: part of
  some values from: chloroplast stroma
definition: Unstacked thylakoids that connect the grana stacks through the stroma.
has_obo_namespace: cellular_component
id: GO:0009533

Axiom
annotated source: chloroplast stromal thylakoid
annotated property: definition
annotated target: Unstacked thylakoids that connect the grana stacks through the stroma.
database_cross_reference: ISBN:0943088399

chloroplast thylakoid
type: Class
equivalent class: Class
  intersection of: thylakoid
  intersection of: Restriction
    on property: part of
    some values from: chloroplast
subclass of: plastid thylakoid
subclass of: Restriction
  on property: part of
  some values from: chloroplast
definition: Sac-like membranous structures (cisternae) in a chloroplast combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. An example of this component is found in Arabidopsis thaliana.
has_obo_namespace: cellular_component
id: GO:0009534

Axiom
annotated source: chloroplast thylakoid
annotated property: definition
annotated target: Sac-like membranous structures (cisternae) in a chloroplast combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. An example of this component is found in Arabidopsis thaliana.
database_cross_reference: GOC:mtg_sensu
database_cross_reference: ISBN:0943088399

plastid
type: Class
subclass of: intracellular membrane-bounded organelle
subclass of: Restriction
  on property: part of
  some values from: cytoplasm
definition: Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.
never in taxon: NCBITaxon 2
never in taxon: NCBITaxon 2157
never in taxon: NCBITaxon_28009
never in taxon: NCBITaxon_33208
never in taxon: NCBITaxon 4751
never in taxon: NCBITaxon_554915
database_cross_reference: Wikipedia:Plastid
has_obo_namespace: cellular_component
id: GO:0009536
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant

Axiom
annotated source: plastid
annotated property: definition
annotated target: Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198547684

proplastid
type: Class
subclass of: plastid
definition: The precursor of other plastids.
has_obo_namespace: cellular_component
id: GO:0009537

Axiom
annotated source: proplastid
annotated property: definition
annotated target: The precursor of other plastids.
database_cross_reference: ISBN:0943088399

fertilization
type: Class
subclass of: reproductive process
subclass of: Restriction
  on property: part of
  some values from: sexual reproduction
definition: The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).
database_cross_reference: Wikipedia:Fertilisation
has_exact_synonym: syngamy
has_obo_namespace: biological_process
id: GO:0009566

Axiom
annotated source: fertilization
annotated property: definition
annotated target: The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).
database_cross_reference: GOC:tb
database_cross_reference: ISBN:0198506732

chloroplast stroma
type: Class
subclass of: plastid stroma
subclass of: Restriction
  on property: part of
  some values from: chloroplast
definition: The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
has_obo_namespace: cellular_component
id: GO:0009570

Axiom
annotated source: chloroplast stroma
annotated property: definition
annotated target: The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
database_cross_reference: ISBN:0198547684

proplastid stroma
type: Class
subclass of: plastid stroma
subclass of: Restriction
  on property: part of
  some values from: proplastid
definition: The space enclosed by the double membrane of a proplastid.
has_obo_namespace: cellular_component
id: GO:0009571

Axiom
annotated source: proplastid stroma
annotated property: definition
annotated target: The space enclosed by the double membrane of a proplastid.
database_cross_reference: GOC:jl

thylakoid
type: Class
subclass of: GO_0110165
subclass of: Restriction
  on property: part of
  some values from: intracellular
definition: A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation.
never in taxon: NCBITaxon_33208
database_cross_reference: Wikipedia:Thylakoid
has_obo_namespace: cellular_component
has_related_synonym: photosynthetic membrane
id: GO:0009579
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
comment: A thylakoid is not considered an organelle, but some thylakoids are part of organelles.

Axiom
annotated source: thylakoid
annotated property: definition
annotated target: A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation.
database_cross_reference: GOC:ds
database_cross_reference: GOC:mtg_sensu
database_cross_reference: ISBN:0198506732

detection of external stimulus
type: Class
subclass of: response to external stimulus
subclass of: GO_0051606
definition: The series of events in which an external stimulus is received by a cell and converted into a molecular signal.
has_obo_namespace: biological_process
has_related_synonym: perception of external stimulus
id: GO:0009581

Axiom
annotated source: detection of external stimulus
annotated property: definition
annotated target: The series of events in which an external stimulus is received by a cell and converted into a molecular signal.
database_cross_reference: GOC:hb

detection of abiotic stimulus
type: Class
subclass of: response to abiotic stimulus
subclass of: GO_0051606
definition: The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal.
has_obo_namespace: biological_process
has_related_synonym: perception of abiotic stimulus
id: GO:0009582

Axiom
annotated source: detection of abiotic stimulus
annotated property: definition
annotated target: The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal.
database_cross_reference: GOC:hb

detection of light stimulus
type: Class
subclass of: response to light stimulus
subclass of: detection of external stimulus
subclass of: detection of abiotic stimulus
definition: The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal.
has_exact_synonym: detection of light
has_obo_namespace: biological_process
has_related_synonym: perception of light
id: GO:0009583

Axiom
annotated source: detection of light stimulus
annotated property: definition
annotated target: The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal.
database_cross_reference: GOC:go_curators

detection of visible light
type: Class
subclass of: detection of light stimulus
definition: The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm.
has_obo_namespace: biological_process
has_related_synonym: perception of visible light
id: GO:0009584

Axiom
annotated source: detection of visible light
annotated property: definition
annotated target: The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732

detection of UV
type: Class
subclass of: response to UV
subclass of: detection of light stimulus
definition: The series of events in which an ultraviolet radiation (UV light) stimulus is received and converted into a molecular signal. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
has_exact_synonym: detection of UV light stimulus
has_exact_synonym: detection of UV radiation stimulus
has_exact_synonym: detection of ultraviolet light stimulus
has_exact_synonym: detection of ultraviolet radiation stimulus
has_obo_namespace: biological_process
has_related_synonym: perception of UV
id: GO:0009589

Axiom
annotated source: detection of UV
annotated property: definition
annotated target: The series of events in which an ultraviolet radiation (UV light) stimulus is received and converted into a molecular signal. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
database_cross_reference: GOC:dos
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:hb
database_cross_reference: ISBN:0198506732

detection of biotic stimulus
type: Class
subclass of: response to biotic stimulus
subclass of: GO_0051606
definition: The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal.
has_alternative_id: GO:0009596
has_obo_namespace: biological_process
has_related_synonym: perception of biotic stimulus
id: GO:0009595

Axiom
annotated source: detection of biotic stimulus
annotated property: definition
annotated target: The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal.
database_cross_reference: GOC:hb

response to external stimulus
type: Class
subclass of: GO_0050896
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.
has_exact_synonym: response to environmental stimulus
has_obo_namespace: biological_process
id: GO:0009605
in_subset: gocheck do not manually annotate
in_subset: goslim drosophila
in_subset: goslim plant
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to external stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.
database_cross_reference: GOC:hb

response to biotic stimulus
type: Class
subclass of: GO_0050896
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.
has_narrow_synonym: response to biotic stress
has_obo_namespace: biological_process
id: GO:0009607
in_subset: gocheck do not manually annotate
in_subset: goslim metagenomics
in_subset: goslim plant
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to biotic stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.
database_cross_reference: GOC:hb

response to wounding
type: Class
subclass of: response to stress
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
has_alternative_id: GO:0002245
has_exact_synonym: physiological response to wounding
has_obo_namespace: biological_process
id: GO:0009611

Axiom
annotated source: response to wounding
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
database_cross_reference: GOC:go_curators

response to virus
type: Class
subclass of: GO_0051707
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
has_exact_synonym: response to viruses
has_obo_namespace: biological_process
id: GO:0009615

Axiom
annotated source: response to virus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
database_cross_reference: GOC:hb

response to abiotic stimulus
type: Class
subclass of: GO_0050896
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus.
IAO_0000233: https://github.com/geneontology/go-ontology/issues/16572
has_narrow_synonym: response to abiotic stress
has_obo_namespace: biological_process
id: GO:0009628
in_subset: gocheck do not manually annotate
in_subset: goslim metagenomics
in_subset: goslim plant
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to abiotic stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus.
database_cross_reference: GOC:hb

response to toxic substance
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
has_narrow_synonym: detoxification response
has_obo_namespace: biological_process
has_related_synonym: toxin resistance
has_related_synonym: toxin susceptibility/resistance
id: GO:0009636
in_subset: goslim chembl

Axiom
annotated source: response to toxic substance
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
database_cross_reference: GOC:lr

response to blue light
type: Class
subclass of: response to light stimulus
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm.
has_exact_synonym: response to blue light stimulus
has_obo_namespace: biological_process
id: GO:0009637

Axiom
annotated source: response to blue light
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm.
database_cross_reference: GOC:ai
database_cross_reference: GOC:mtg_far_red

response to red or far red light
type: Class
subclass of: response to light stimulus
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs.
has_obo_namespace: biological_process
id: GO:0009639

Axiom
annotated source: response to red or far red light
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs.
database_cross_reference: GOC:ai
database_cross_reference: GOC:mtg_far_red

response to light intensity
type: Class
subclass of: response to light stimulus
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus.
has_obo_namespace: biological_process
id: GO:0009642

Axiom
annotated source: response to light intensity
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus.
database_cross_reference: GOC:go_curators

response to high light intensity
type: Class
subclass of: response to light intensity
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus.
has_obo_namespace: biological_process
id: GO:0009644

Axiom
annotated source: response to high light intensity
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus.
database_cross_reference: GOC:go_curators

response to low light intensity stimulus
type: Class
subclass of: response to light intensity
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. Low light intensity is defined as a level of electromagnetic radiation at or below 0.1 micromols/m2.
has_obo_namespace: biological_process
id: GO:0009645

Axiom
annotated source: response to low light intensity stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. Low light intensity is defined as a level of electromagnetic radiation at or below 0.1 micromols/m2.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:mtg_far_red

response to absence of light
type: Class
subclass of: response to light intensity
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli.
has_obo_namespace: biological_process
has_related_synonym: response to darkness
id: GO:0009646

Axiom
annotated source: response to absence of light
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli.
database_cross_reference: GOC:go_curators

response to salt stress
type: Class
subclass of: response to osmotic stress
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
has_exact_synonym: response to ionic osmotic stress
has_exact_synonym: salinity response
has_obo_namespace: biological_process
id: GO:0009651

Axiom
annotated source: response to salt stress
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
database_cross_reference: GOC:jl

anatomical structure morphogenesis
type: Class
subclass of: developmental process
subclass of: Restriction
  on property: part of
  some values from: anatomical structure development
definition: The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
has_broad_synonym: embryogenesis and morphogenesis
database_cross_reference: Wikipedia:Morphogenesis
has_exact_synonym: anatomical structure organization
has_exact_synonym: morphogenesis
has_obo_namespace: biological_process
id: GO:0009653

Axiom
annotated source: anatomical structure morphogenesis
annotated property: definition
annotated target: The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0521436125

response to endogenous stimulus
type: Class
subclass of: GO_0050896
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism.
has_obo_namespace: biological_process
id: GO:0009719
in_subset: gocheck do not manually annotate
in_subset: goslim plant
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to endogenous stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism.
database_cross_reference: GOC:sm

response to hormone
type: Class
subclass of: response to endogenous stimulus
subclass of: response to organic substance
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
has_exact_synonym: response to hormone stimulus
has_obo_namespace: biological_process
has_related_synonym: growth regulator
id: GO:0009725

Axiom
annotated source: response to hormone
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
database_cross_reference: GOC:jl

Axiom
annotated source: response to hormone
annotated property: has_exact_synonym
annotated target: response to hormone stimulus
database_cross_reference: GOC:dos

hormone-mediated signaling pathway
type: Class
subclass of: signal transduction
subclass of: Restriction
  on property: part of
  some values from: cellular response to hormone stimulus
definition: A series of molecular signals mediated by the detection of a hormone.
has_exact_synonym: hormone mediated signalling
has_obo_namespace: biological_process
id: GO:0009755

Axiom
annotated source: hormone-mediated signaling pathway
annotated property: definition
annotated target: A series of molecular signals mediated by the detection of a hormone.
database_cross_reference: GOC:sm

blue light signaling pathway
type: Class
subclass of: intracellular receptor signaling pathway
subclass of: GO_0071483
definition: The series of molecular signals initiated upon sensing of blue light by photoreceptor molecule, at a wavelength between 400nm and 470nm.
has_exact_synonym: blue light signalling pathway
has_obo_namespace: biological_process
id: GO:0009785

Axiom
annotated source: blue light signaling pathway
annotated property: definition
annotated target: The series of molecular signals initiated upon sensing of blue light by photoreceptor molecule, at a wavelength between 400nm and 470nm.
database_cross_reference: GOC:lr
database_cross_reference: GOC:sm

regulation of asymmetric cell division
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: asymmetric cell division
subclass of: GO_0051302
subclass of: Restriction
  on property: regulates
  some values from: asymmetric cell division
definition: Any process that modulates the frequency, rate or extent of asymmetric cell division.
has_obo_namespace: biological_process
id: GO:0009786

Axiom
annotated source: regulation of asymmetric cell division
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of asymmetric cell division.
database_cross_reference: GOC:lr

embryo development
type: Class
subclass of: multicellular organism development
definition: The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
has_alternative_id: GO:0009795
has_broad_synonym: embryogenesis and morphogenesis
database_cross_reference: Wikipedia:Embryogenesis
has_exact_synonym: embryogenesis
has_exact_synonym: embryonal development
has_obo_namespace: biological_process
id: GO:0009790
in_subset: gocheck do not manually annotate
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim plant

Axiom
annotated source: embryo development
annotated property: definition
annotated target: The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:mtg_sensu

pollination
type: Class
subclass of: reproductive process
subclass of: Restriction
  on property: part of
  some values from: multi-multicellular organism process
definition: The cascade of biological processes occurring in plants beginning when the pollen lands on the female reproductive organs of a plant and continuing up to, but not including, fertilization, as defined by sperm-egg cell fusion.
database_cross_reference: Wikipedia:Pollination
has_obo_namespace: biological_process
id: GO:0009856
in_subset: goslim plant

Axiom
annotated source: pollination
annotated property: definition
annotated target: The cascade of biological processes occurring in plants beginning when the pollen lands on the female reproductive organs of a plant and continuing up to, but not including, fertilization, as defined by sperm-egg cell fusion.
database_cross_reference: GOC:tb
database_cross_reference: PMID:10973091

animal organ morphogenesis
type: Class
subclass of: anatomical structure morphogenesis
subclass of: Restriction
  on property: part of
  some values from: animal organ development
definition: Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
has_broad_synonym: histogenesis and organogenesis
has_obo_namespace: biological_process
id: GO:0009887

Axiom
annotated source: animal organ morphogenesis
annotated property: definition
annotated target: Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
database_cross_reference: GOC:dgh
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0471245208
database_cross_reference: ISBN:0721662544

tissue development
type: Class
subclass of: anatomical structure development
definition: The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.
never in taxon: NCBITaxon_147554
never in taxon: NCBITaxon_33630
never in taxon: NCBITaxon_33682
never in taxon: NCBITaxon_38254
never in taxon: NCBITaxon 4891
has_broad_synonym: histogenesis and organogenesis
database_cross_reference: Wikipedia:Histogenesis
has_exact_synonym: histogenesis
has_obo_namespace: biological_process
id: GO:0009888

Axiom
annotated source: tissue development
annotated property: definition
annotated target: The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.
database_cross_reference: ISBN:0471245208

regulation of biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: biosynthetic process
subclass of: regulation of metabolic process
subclass of: Restriction
  on property: regulates
  some values from: biosynthetic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.
has_exact_synonym: regulation of anabolism
has_exact_synonym: regulation of biosynthesis
has_exact_synonym: regulation of formation
has_exact_synonym: regulation of synthesis
has_obo_namespace: biological_process
id: GO:0009889

Axiom
annotated source: regulation of biosynthetic process
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.
database_cross_reference: GOC:go_curators

negative regulation of biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: biosynthetic process
subclass of: regulation of biosynthetic process
subclass of: negative regulation of metabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: biosynthetic process
definition: Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.
has_exact_synonym: down regulation of biosynthetic process
has_exact_synonym: down-regulation of biosynthetic process
has_exact_synonym: downregulation of biosynthetic process
has_exact_synonym: negative regulation of anabolism
has_exact_synonym: negative regulation of biosynthesis
has_exact_synonym: negative regulation of formation
has_exact_synonym: negative regulation of synthesis
has_narrow_synonym: inhibition of biosynthetic process
has_obo_namespace: biological_process
id: GO:0009890

Axiom
annotated source: negative regulation of biosynthetic process
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.
database_cross_reference: GOC:go_curators

positive regulation of biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: biosynthetic process
subclass of: regulation of biosynthetic process
subclass of: positive regulation of metabolic process
subclass of: Restriction
  on property: positively regulates
  some values from: biosynthetic process
definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.
has_exact_synonym: positive regulation of anabolism
has_exact_synonym: positive regulation of biosynthesis
has_exact_synonym: positive regulation of formation
has_exact_synonym: positive regulation of synthesis
has_exact_synonym: up regulation of biosynthetic process
has_exact_synonym: up-regulation of biosynthetic process
has_exact_synonym: upregulation of biosynthetic process
has_narrow_synonym: activation of biosynthetic process
has_narrow_synonym: stimulation of biosynthetic process
has_obo_namespace: biological_process
id: GO:0009891

Axiom
annotated source: positive regulation of biosynthetic process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.
database_cross_reference: GOC:go_curators

negative regulation of metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: metabolic process
subclass of: regulation of metabolic process
subclass of: negative regulation of biological process
subclass of: Restriction
  on property: negatively regulates
  some values from: metabolic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
has_alternative_id: GO:0044252
has_exact_synonym: down regulation of metabolic process
has_exact_synonym: down-regulation of metabolic process
has_exact_synonym: downregulation of metabolic process
has_exact_synonym: negative regulation of metabolism
has_exact_synonym: negative regulation of organismal metabolism
has_narrow_synonym: inhibition of metabolic process
has_narrow_synonym: inhibition of organismal metabolic process
has_narrow_synonym: negative regulation of multicellular organismal metabolic process
has_obo_namespace: biological_process
id: GO:0009892

Axiom
annotated source: negative regulation of metabolic process
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
database_cross_reference: GOC:go_curators

positive regulation of metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: metabolic process
subclass of: regulation of metabolic process
subclass of: positive regulation of biological process
subclass of: Restriction
  on property: positively regulates
  some values from: metabolic process
definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
has_alternative_id: GO:0044253
has_exact_synonym: positive regulation of metabolism
has_exact_synonym: up regulation of metabolic process
has_exact_synonym: up-regulation of metabolic process
has_exact_synonym: upregulation of metabolic process
has_narrow_synonym: activation of metabolic process
has_narrow_synonym: positive regulation of multicellular organismal metabolic process
has_narrow_synonym: positive regulation of organismal metabolism
has_narrow_synonym: stimulation of metabolic process
has_narrow_synonym: stimulation of organismal metabolic process
has_narrow_synonym: up-regulation of organismal metabolic process
has_obo_namespace: biological_process
id: GO:0009893

Axiom
annotated source: positive regulation of metabolic process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
database_cross_reference: GOC:go_curators

regulation of catabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: catabolic process
subclass of: regulation of metabolic process
subclass of: Restriction
  on property: regulates
  some values from: catabolic process
definition: Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances.
has_exact_synonym: regulation of breakdown
has_exact_synonym: regulation of catabolism
has_exact_synonym: regulation of degradation
has_obo_namespace: biological_process
id: GO:0009894

Axiom
annotated source: regulation of catabolic process
annotated property: definition
annotated target: Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances.
database_cross_reference: GOC:go_curators

negative regulation of catabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: catabolic process
subclass of: negative regulation of metabolic process
subclass of: regulation of catabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: catabolic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances.
has_exact_synonym: down regulation of catabolic process
has_exact_synonym: down-regulation of catabolic process
has_exact_synonym: downregulation of catabolic process
has_exact_synonym: negative regulation of breakdown
has_exact_synonym: negative regulation of catabolism
has_exact_synonym: negative regulation of degradation
has_narrow_synonym: inhibition of catabolic process
has_obo_namespace: biological_process
id: GO:0009895

Axiom
annotated source: negative regulation of catabolic process
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances.
database_cross_reference: GOC:go_curators

positive regulation of catabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: catabolic process
subclass of: positive regulation of metabolic process
subclass of: regulation of catabolic process
subclass of: Restriction
  on property: positively regulates
  some values from: catabolic process
definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances.
has_exact_synonym: positive regulation of breakdown
has_exact_synonym: positive regulation of catabolism
has_exact_synonym: positive regulation of degradation
has_exact_synonym: up regulation of catabolic process
has_exact_synonym: up-regulation of catabolic process
has_exact_synonym: upregulation of catabolic process
has_narrow_synonym: activation of catabolic process
has_narrow_synonym: stimulation of catabolic process
has_obo_namespace: biological_process
id: GO:0009896

Axiom
annotated source: positive regulation of catabolic process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances.
database_cross_reference: GOC:go_curators

chloroplast envelope
type: Class
subclass of: plastid envelope
subclass of: Restriction
  on property: part of
  some values from: chloroplast
definition: The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
has_obo_namespace: cellular_component
id: GO:0009941

Axiom
annotated source: chloroplast envelope
annotated property: definition
annotated target: The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
database_cross_reference: GOC:tb

regulation of signal transduction
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: signal transduction
subclass of: regulation of cell communication
subclass of: regulation of signaling
subclass of: regulation of response to stimulus
subclass of: Restriction
  on property: regulates
  some values from: signal transduction
definition: Any process that modulates the frequency, rate or extent of signal transduction.
has_alternative_id: GO:0035466
has_obo_namespace: biological_process
has_related_synonym: regulation of signaling pathway
has_related_synonym: regulation of signalling pathway
id: GO:0009966

Axiom
annotated source: regulation of signal transduction
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of signal transduction.
database_cross_reference: GOC:sm

Axiom
annotated source: regulation of signal transduction
annotated property: has_related_synonym
annotated target: regulation of signalling pathway
database_cross_reference: GOC:mah

positive regulation of signal transduction
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: signal transduction
subclass of: regulation of signal transduction
subclass of: positive regulation of cell communication
subclass of: positive regulation of signaling
subclass of: positive regulation of response to stimulus
subclass of: Restriction
  on property: positively regulates
  some values from: signal transduction
definition: Any process that activates or increases the frequency, rate or extent of signal transduction.
has_alternative_id: GO:0035468
has_exact_synonym: up regulation of signal transduction
has_exact_synonym: up-regulation of signal transduction
has_exact_synonym: upregulation of signal transduction
has_narrow_synonym: activation of signal transduction
has_narrow_synonym: stimulation of signal transduction
has_obo_namespace: biological_process
has_related_synonym: positive regulation of signaling pathway
has_related_synonym: positive regulation of signalling pathway
id: GO:0009967

Axiom
annotated source: positive regulation of signal transduction
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of signal transduction.
database_cross_reference: GOC:sm

Axiom
annotated source: positive regulation of signal transduction
annotated property: has_related_synonym
annotated target: positive regulation of signalling pathway
database_cross_reference: GOC:mah

negative regulation of signal transduction
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: signal transduction
subclass of: regulation of signal transduction
subclass of: negative regulation of cell communication
subclass of: negative regulation of signaling
subclass of: negative regulation of response to stimulus
subclass of: Restriction
  on property: negatively regulates
  some values from: signal transduction
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.
has_alternative_id: GO:0035467
has_exact_synonym: down regulation of signal transduction
has_exact_synonym: down-regulation of signal transduction
has_exact_synonym: downregulation of signal transduction
has_narrow_synonym: inhibition of signal transduction
has_obo_namespace: biological_process
has_related_synonym: negative regulation of signaling pathway
has_related_synonym: negative regulation of signalling pathway
id: GO:0009968

Axiom
annotated source: negative regulation of signal transduction
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.
database_cross_reference: GOC:sm

Axiom
annotated source: negative regulation of signal transduction
annotated property: has_related_synonym
annotated target: negative regulation of signalling pathway
database_cross_reference: GOC:mah

cellular process
type: Class
subclass of: biological_process
disjoint with: biological phase
definition: Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
created by: janelomax
creation date: 2012-12-11T16:56:55Z
has_alternative_id: GO:0008151
has_alternative_id: GO:0044763
has_alternative_id: GO:0050875
has_exact_synonym: cell physiology
has_exact_synonym: cellular physiological process
has_narrow_synonym: cell growth and/or maintenance
has_obo_namespace: biological_process
has_related_synonym: single-organism cellular process
id: GO:0009987
in_subset: goslim plant

Axiom
annotated source: cellular process
annotated property: definition
annotated target: Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:isa_complete

response to extracellular stimulus
type: Class
subclass of: response to external stimulus
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.
has_obo_namespace: biological_process
id: GO:0009991

Axiom
annotated source: response to extracellular stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.
database_cross_reference: GOC:go_curators

oocyte differentiation
type: Class
subclass of: developmental process involved in reproduction
subclass of: cellular process involved in reproduction in multicellular organism
subclass of: cell differentiation
subclass of: Restriction
  on property: part of
  some values from: oogenesis
definition: The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete.
has_exact_synonym: oocyte cell differentiation
has_obo_namespace: biological_process
id: GO:0009994

Axiom
annotated source: oocyte differentiation
annotated property: definition
annotated target: The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:mtg_sensu

red or far-red light signaling pathway
type: Class
subclass of: signal transduction
subclass of: GO_0071489
definition: The series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs.
has_broad_synonym: phytochrome signaling pathway
has_exact_synonym: red or far red light signaling pathway
has_exact_synonym: red or far-red light signal transduction
has_exact_synonym: red or far-red light signalling pathway
has_exact_synonym: red/far red light signaling pathway
has_obo_namespace: biological_process
id: GO:0010017

Axiom
annotated source: red or far-red light signaling pathway
annotated property: definition
annotated target: The series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs.
database_cross_reference: GOC:lr
database_cross_reference: GOC:mtg_far_red
database_cross_reference: GOC:sm

Axiom
annotated source: red or far-red light signaling pathway
annotated property: has_exact_synonym
annotated target: red or far red light signaling pathway
database_cross_reference: GOC:bf
database_cross_reference: GOC:tb

Axiom
annotated source: red or far-red light signaling pathway
annotated property: has_exact_synonym
annotated target: red or far-red light signal transduction
database_cross_reference: GOC:signaling

far-red light signaling pathway
type: Class
subclass of: red or far-red light signaling pathway
subclass of: GO_0071490
definition: The series of molecular signals initiated upon sensing of far red light by a photoreceptor molecule. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs.
has_exact_synonym: far red light signalling pathway
has_exact_synonym: far red signaling pathway
has_exact_synonym: far-red light signal transduction
has_obo_namespace: biological_process
id: GO:0010018

Axiom
annotated source: far-red light signaling pathway
annotated property: definition
annotated target: The series of molecular signals initiated upon sensing of far red light by a photoreceptor molecule. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs.
database_cross_reference: GOC:lr
database_cross_reference: GOC:mtg_far_red
database_cross_reference: GOC:sm

Axiom
annotated source: far-red light signaling pathway
annotated property: has_exact_synonym
annotated target: far red signaling pathway
database_cross_reference: GOC:tb

Axiom
annotated source: far-red light signaling pathway
annotated property: has_exact_synonym
annotated target: far-red light signal transduction
database_cross_reference: GOC:signaling

meiotic chromosome condensation
type: Class
equivalent class: Class
  intersection of: chromosome condensation
  intersection of: Restriction
    on property: part of
    some values from: GO_0051321
subclass of: chromosome condensation
subclass of: GO_0070192
definition: Compaction of chromatin structure prior to meiosis in eukaryotic cells.
has_exact_synonym: chromosome condensation involved in meiotic cell cycle
has_obo_namespace: biological_process
id: GO:0010032

Axiom
annotated source: meiotic chromosome condensation
annotated property: definition
annotated target: Compaction of chromatin structure prior to meiosis in eukaryotic cells.
database_cross_reference: PMID:10072401

Axiom
annotated source: meiotic chromosome condensation
annotated property: has_exact_synonym
annotated target: chromosome condensation involved in meiotic cell cycle
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

response to organic substance
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
has_alternative_id: GO:1990367
has_narrow_synonym: process resulting in tolerance to organic substance
has_obo_namespace: biological_process
id: GO:0010033

Axiom
annotated source: response to organic substance
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
database_cross_reference: GOC:sm
database_cross_reference: PMID:23356676

response to inorganic substance
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.
has_obo_namespace: biological_process
id: GO:0010035

Axiom
annotated source: response to inorganic substance
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.
database_cross_reference: GOC:sm

response to metal ion
type: Class
subclass of: response to inorganic substance
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.
has_exact_synonym: response to metal
has_narrow_synonym: response to heavy metal
has_obo_namespace: biological_process
has_related_synonym: heavy metal sensitivity/resistance
id: GO:0010038

Axiom
annotated source: response to metal ion
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.
database_cross_reference: GOC:sm

response to red light
type: Class
subclass of: response to red or far red light
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs.
has_exact_synonym: response to red light stimulus
has_obo_namespace: biological_process
id: GO:0010114

Axiom
annotated source: response to red light
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs.
database_cross_reference: GOC:mtg_far_red
database_cross_reference: GOC:sm

red light signaling pathway
type: Class
subclass of: red or far-red light signaling pathway
subclass of: GO_0071491
definition: The series of molecular signals initiated upon sensing of red light by a photoreceptor molecule. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs.
has_exact_synonym: red light phototransduction
has_exact_synonym: red light signal transduction
has_exact_synonym: red light signalling pathway
has_obo_namespace: biological_process
id: GO:0010161

Axiom
annotated source: red light signaling pathway
annotated property: definition
annotated target: The series of molecular signals initiated upon sensing of red light by a photoreceptor molecule. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs.
database_cross_reference: GOC:mtg_far_red
database_cross_reference: GOC:sm

Axiom
annotated source: red light signaling pathway
annotated property: has_exact_synonym
annotated target: red light phototransduction
database_cross_reference: GOC:signaling

Axiom
annotated source: red light signaling pathway
annotated property: has_exact_synonym
annotated target: red light signal transduction
database_cross_reference: GOC:signaling

response to X-ray
type: Class
subclass of: response to ionizing radiation
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz).
has_exact_synonym: response to X-ray radiation stimulus
has_obo_namespace: biological_process
id: GO:0010165

Axiom
annotated source: response to X-ray
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz).
database_cross_reference: GOC:sm
database_cross_reference: Wikipedia:X-ray

regulation of cellular defense response
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cellular defense response
subclass of: regulation of defense response
subclass of: Restriction
  on property: regulates
  some values from: cellular defense response
definition: Any process that modulates the frequency, rate or extent of cellular defense response.
has_exact_synonym: regulation of cellular defence response
has_obo_namespace: biological_process
id: GO:0010185

Axiom
annotated source: regulation of cellular defense response
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of cellular defense response.
database_cross_reference: GOC:sm

positive regulation of cellular defense response
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: cellular defense response
subclass of: regulation of cellular defense response
subclass of: positive regulation of defense response
subclass of: Restriction
  on property: positively regulates
  some values from: cellular defense response
definition: Any process that activates or increases the frequency, rate or extent of cellular defense response.
has_exact_synonym: positive regulation of cellular defence response
has_exact_synonym: up regulation of cellular defense response
has_exact_synonym: up-regulation of cellular defense response
has_exact_synonym: upregulation of cellular defense response
has_narrow_synonym: activation of cellular defense response
has_narrow_synonym: stimulation of cellular defense response
has_obo_namespace: biological_process
id: GO:0010186

Axiom
annotated source: positive regulation of cellular defense response
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of cellular defense response.
database_cross_reference: GOC:sm

response to ionizing radiation
type: Class
subclass of: response to radiation
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.
has_exact_synonym: response to ionising radiation
has_exact_synonym: response to ionizing radiation stimulus
has_obo_namespace: biological_process
id: GO:0010212

Axiom
annotated source: response to ionizing radiation
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.
database_cross_reference: PMID:12509526

response to far red light
type: Class
subclass of: response to red or far red light
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of far red light stimulus. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs.
has_exact_synonym: response to far red light stimulus
has_obo_namespace: biological_process
id: GO:0010218

Axiom
annotated source: response to far red light
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of far red light stimulus. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs.
database_cross_reference: GOC:mtg_far_red
database_cross_reference: GOC:tb

response to UV-B
type: Class
subclass of: response to UV
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm.
has_exact_synonym: response to UV-B light stimulus
has_exact_synonym: response to UV-B radiation stimulus
has_exact_synonym: response to UVB light stimulus
has_exact_synonym: response to UVB radiation stimulus
has_exact_synonym: response to medium wave ultraviolet light stimulus
has_exact_synonym: response to medium wave ultraviolet radiation stimulus
has_obo_namespace: biological_process
id: GO:0010224

Axiom
annotated source: response to UV-B
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm.
database_cross_reference: GOC:tb

response to UV-C
type: Class
subclass of: response to UV
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm.
has_exact_synonym: response to UV-C light stimulus
has_exact_synonym: response to UV-C radiation stimulus
has_exact_synonym: response to UVC light stimulus
has_exact_synonym: response to UVC radiation stimulus
has_exact_synonym: response to germicidal ultraviolet light stimulus
has_exact_synonym: response to germicidal ultraviolet radiation stimulus
has_exact_synonym: response to shortwave ultraviolet light stimulus
has_exact_synonym: response to shortwave ultraviolet radiation stimulus
has_obo_namespace: biological_process
id: GO:0010225

Axiom
annotated source: response to UV-C
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm.
database_cross_reference: GOC:tb

response to lithium ion
type: Class
subclass of: response to metal ion
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus.
has_obo_namespace: biological_process
id: GO:0010226

Axiom
annotated source: response to lithium ion
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus.
database_cross_reference: GOC:tb

response to organonitrogen compound
type: Class
subclass of: response to organic substance
subclass of: GO_1901698
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.
has_exact_synonym: response to organic nitrogen
has_obo_namespace: biological_process
id: GO:0010243

Axiom
annotated source: response to organonitrogen compound
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.
database_cross_reference: PMID:9869419

endomembrane system organization
type: Class
subclass of: cellular component organization
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system.
has_exact_synonym: endomembrane organization
has_exact_synonym: endomembrane system organisation
has_obo_namespace: biological_process
id: GO:0010256
in_subset: goslim drosophila

Axiom
annotated source: endomembrane system organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system.
database_cross_reference: GOC:mah
database_cross_reference: GOC:sm

Axiom
annotated source: endomembrane system organization
annotated property: has_exact_synonym
annotated target: endomembrane system organisation
database_cross_reference: GOC:mah

membrane invagination
type: Class
subclass of: GO_0061024
definition: The infolding of a membrane.
created by: jl
creation date: 2013-12-02T13:58:34Z
has_alternative_id: GO:1902534
has_obo_namespace: biological_process
has_related_synonym: single-organism membrane invagination
id: GO:0010324
in_subset: goslim yeast

Axiom
annotated source: membrane invagination
annotated property: definition
annotated target: The infolding of a membrane.
database_cross_reference: GOC:tb

response to gamma radiation
type: Class
subclass of: response to ionizing radiation
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum.
has_obo_namespace: biological_process
has_related_synonym: response to gamma ray
has_related_synonym: response to gamma-ray photon
id: GO:0010332

Axiom
annotated source: response to gamma radiation
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum.
database_cross_reference: GOC:tair_curators

negative regulation of peptidase activity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: peptidase activity
subclass of: negative regulation of proteolysis
subclass of: GO_0051346
subclass of: GO_0052547
subclass of: Restriction
  on property: negatively regulates
  some values from: peptidase activity
definition: Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins.
has_obo_namespace: biological_process
id: GO:0010466

Axiom
annotated source: negative regulation of peptidase activity
annotated property: definition
annotated target: Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

gene expression
type: Class
subclass of: macromolecule metabolic process
definition: The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
database_cross_reference: Wikipedia:Gene_expression
has_obo_namespace: biological_process
id: GO:0010467
in_subset: goslim flybase ribbon

Axiom
annotated source: gene expression
annotated property: definition
annotated target: The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

regulation of gene expression
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: gene expression
subclass of: GO_0060255
subclass of: Restriction
  on property: regulates
  some values from: gene expression
definition: Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
database_cross_reference: Wikipedia:Regulation_of_gene_expression
has_narrow_synonym: regulation of protein expression
has_obo_namespace: biological_process
has_related_synonym: regulation of gene product expression
id: GO:0010468
comment: This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availability of mRNA or circRNA for translation and thereby regulates the rate of production of the encoded protein via translation.

Axiom
annotated source: regulation of gene expression
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

regulation of signaling receptor activity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: signaling receptor activity
subclass of: regulation of signal transduction
subclass of: GO_0065009
subclass of: Restriction
  on property: regulates
  some values from: signaling receptor activity
definition: Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity.
has_broad_synonym: regulation of receptor activity
has_obo_namespace: biological_process
id: GO:0010469

Axiom
annotated source: regulation of signaling receptor activity
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

regulation of autophagy
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: autophagy
subclass of: regulation of cellular catabolic process
subclass of: Restriction
  on property: regulates
  some values from: autophagy
definition: Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
has_obo_namespace: biological_process
id: GO:0010506

Axiom
annotated source: regulation of autophagy
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

negative regulation of autophagy
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: autophagy
subclass of: regulation of autophagy
subclass of: negative regulation of cellular catabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: autophagy
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
has_obo_namespace: biological_process
id: GO:0010507

Axiom
annotated source: negative regulation of autophagy
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

positive regulation of autophagy
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: autophagy
subclass of: regulation of autophagy
subclass of: positive regulation of cellular catabolic process
subclass of: Restriction
  on property: positively regulates
  some values from: autophagy
definition: Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
has_obo_namespace: biological_process
id: GO:0010508

Axiom
annotated source: positive regulation of autophagy
annotated property: definition
annotated target: Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

regulation of platelet activation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: platelet activation
subclass of: regulation of blood coagulation
subclass of: GO_0050865
subclass of: Restriction
  on property: regulates
  some values from: platelet activation
definition: Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.
has_obo_namespace: biological_process
id: GO:0010543

Axiom
annotated source: regulation of platelet activation
annotated property: definition
annotated target: Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

negative regulation of platelet activation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: platelet activation
subclass of: regulation of platelet activation
subclass of: negative regulation of blood coagulation
subclass of: GO_0050866
subclass of: Restriction
  on property: negatively regulates
  some values from: platelet activation
definition: Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.
has_obo_namespace: biological_process
id: GO:0010544

Axiom
annotated source: negative regulation of platelet activation
annotated property: definition
annotated target: Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

regulation of macromolecule biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: macromolecule biosynthetic process
subclass of: regulation of biosynthetic process
subclass of: GO_0060255
subclass of: Restriction
  on property: regulates
  some values from: macromolecule biosynthetic process
definition: Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
has_obo_namespace: biological_process
id: GO:0010556

Axiom
annotated source: regulation of macromolecule biosynthetic process
annotated property: definition
annotated target: Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

positive regulation of macromolecule biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: macromolecule biosynthetic process
subclass of: positive regulation of biosynthetic process
subclass of: regulation of macromolecule biosynthetic process
subclass of: positive regulation of macromolecule metabolic process
subclass of: Restriction
  on property: positively regulates
  some values from: macromolecule biosynthetic process
definition: Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
has_obo_namespace: biological_process
id: GO:0010557

Axiom
annotated source: positive regulation of macromolecule biosynthetic process
annotated property: definition
annotated target: Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

negative regulation of macromolecule biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: macromolecule biosynthetic process
subclass of: negative regulation of biosynthetic process
subclass of: regulation of macromolecule biosynthetic process
subclass of: negative regulation of macromolecule metabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: macromolecule biosynthetic process
definition: Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
has_obo_namespace: biological_process
id: GO:0010558

Axiom
annotated source: negative regulation of macromolecule biosynthetic process
annotated property: definition
annotated target: Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

regulation of glycoprotein biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: glycoprotein biosynthetic process
subclass of: GO_1903018
subclass of: GO_2000112
subclass of: Restriction
  on property: regulates
  some values from: glycoprotein biosynthetic process
definition: Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
has_obo_namespace: biological_process
id: GO:0010559

Axiom
annotated source: regulation of glycoprotein biosynthetic process
annotated property: definition
annotated target: Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

positive regulation of glycoprotein biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: glycoprotein biosynthetic process
subclass of: positive regulation of macromolecule biosynthetic process
subclass of: regulation of glycoprotein biosynthetic process
subclass of: positive regulation of cellular biosynthetic process
subclass of: GO_1903020
subclass of: Restriction
  on property: positively regulates
  some values from: glycoprotein biosynthetic process
definition: Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
has_obo_namespace: biological_process
id: GO:0010560

Axiom
annotated source: positive regulation of glycoprotein biosynthetic process
annotated property: definition
annotated target: Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

negative regulation of glycoprotein biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: glycoprotein biosynthetic process
subclass of: regulation of glycoprotein biosynthetic process
subclass of: GO_1903019
subclass of: GO_2000113
subclass of: Restriction
  on property: negatively regulates
  some values from: glycoprotein biosynthetic process
definition: Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
has_obo_namespace: biological_process
id: GO:0010561

Axiom
annotated source: negative regulation of glycoprotein biosynthetic process
annotated property: definition
annotated target: Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

positive regulation of phosphorus metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: phosphorus metabolic process
subclass of: positive regulation of cellular metabolic process
subclass of: GO_0051174
subclass of: Restriction
  on property: positively regulates
  some values from: phosphorus metabolic process
definition: Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.
has_obo_namespace: biological_process
id: GO:0010562

Axiom
annotated source: positive regulation of phosphorus metabolic process
annotated property: definition
annotated target: Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

negative regulation of phosphorus metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: phosphorus metabolic process
subclass of: negative regulation of cellular metabolic process
subclass of: GO_0051174
subclass of: Restriction
  on property: negatively regulates
  some values from: phosphorus metabolic process
definition: Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.
has_obo_namespace: biological_process
id: GO:0010563

Axiom
annotated source: negative regulation of phosphorus metabolic process
annotated property: definition
annotated target: Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

regulation of cell cycle process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cell cycle process
subclass of: GO_0051726
subclass of: Restriction
  on property: regulates
  some values from: cell cycle process
definition: Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
has_obo_namespace: biological_process
id: GO:0010564

Axiom
annotated source: regulation of cell cycle process
annotated property: definition
annotated target: Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

positive regulation of platelet activation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: platelet activation
subclass of: regulation of platelet activation
subclass of: positive regulation of blood coagulation
subclass of: GO_0050867
subclass of: Restriction
  on property: positively regulates
  some values from: platelet activation
definition: Any process that increases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.
has_obo_namespace: biological_process
id: GO:0010572

Axiom
annotated source: positive regulation of platelet activation
annotated property: definition
annotated target: Any process that increases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.
database_cross_reference: GOC:dph
database_cross_reference: GOC:sl
database_cross_reference: GOC:tb

positive regulation of macromolecule metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: macromolecule metabolic process
subclass of: positive regulation of metabolic process
subclass of: GO_0060255
subclass of: Restriction
  on property: positively regulates
  some values from: macromolecule metabolic process
definition: Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
has_obo_namespace: biological_process
id: GO:0010604

Axiom
annotated source: positive regulation of macromolecule metabolic process
annotated property: definition
annotated target: Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

negative regulation of macromolecule metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: macromolecule metabolic process
subclass of: negative regulation of metabolic process
subclass of: GO_0060255
subclass of: Restriction
  on property: negatively regulates
  some values from: macromolecule metabolic process
definition: Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
has_obo_namespace: biological_process
id: GO:0010605

Axiom
annotated source: negative regulation of macromolecule metabolic process
annotated property: definition
annotated target: Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

posttranscriptional regulation of gene expression
type: Class
subclass of: regulation of gene expression
definition: Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.
has_obo_namespace: biological_process
id: GO:0010608

Axiom
annotated source: posttranscriptional regulation of gene expression
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

programmed cell death involved in cell development
type: Class
equivalent class: Class
  intersection of: programmed cell death
  intersection of: Restriction
    on property: part of
    some values from: cell development
subclass of: programmed cell death
subclass of: cellular developmental process
subclass of: Restriction
  on property: part of
  some values from: cell development
definition: The activation of endogenous cellular processes that result in the death of a cell as part of its development.
has_broad_synonym: developmental programmed cell death
has_broad_synonym: programmed cell death involved in development
has_obo_namespace: biological_process
id: GO:0010623
comment: This process is part of the natural developmental program of some cell types, but it does not always happen as part of the development or shaping of a gross anatomical structure.

Axiom
annotated source: programmed cell death involved in cell development
annotated property: definition
annotated target: The activation of endogenous cellular processes that result in the death of a cell as part of its development.
database_cross_reference: GOC:dph
database_cross_reference: GOC:mtg_apoptosis
database_cross_reference: GOC:tb

positive regulation of gene expression
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: gene expression
subclass of: regulation of gene expression
subclass of: positive regulation of macromolecule metabolic process
subclass of: Restriction
  on property: positively regulates
  some values from: gene expression
definition: Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
has_obo_namespace: biological_process
id: GO:0010628

Axiom
annotated source: positive regulation of gene expression
annotated property: definition
annotated target: Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

negative regulation of gene expression
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: gene expression
subclass of: regulation of gene expression
subclass of: negative regulation of macromolecule metabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: gene expression
definition: Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
has_obo_namespace: biological_process
id: GO:0010629
comment: This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation.

Axiom
annotated source: negative regulation of gene expression
annotated property: definition
annotated target: Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

positive regulation of organelle organization
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: organelle organization
subclass of: regulation of organelle organization
subclass of: GO_0051130
subclass of: Restriction
  on property: positively regulates
  some values from: organelle organization
definition: Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.
has_exact_synonym: positive regulation of organelle organisation
has_obo_namespace: biological_process
has_related_synonym: positive regulation of organelle organization and biogenesis
id: GO:0010638

Axiom
annotated source: positive regulation of organelle organization
annotated property: definition
annotated target: Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

Axiom
annotated source: positive regulation of organelle organization
annotated property: has_exact_synonym
annotated target: positive regulation of organelle organisation
database_cross_reference: GOC:mah

Axiom
annotated source: positive regulation of organelle organization
annotated property: has_related_synonym
annotated target: positive regulation of organelle organization and biogenesis
database_cross_reference: GOC:mah

negative regulation of organelle organization
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: organelle organization
subclass of: regulation of organelle organization
subclass of: GO_0051129
subclass of: Restriction
  on property: negatively regulates
  some values from: organelle organization
definition: Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.
has_exact_synonym: negative regulation of organelle organisation
has_obo_namespace: biological_process
has_related_synonym: negative regulation of organelle organization and biogenesis
id: GO:0010639

Axiom
annotated source: negative regulation of organelle organization
annotated property: definition
annotated target: Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

Axiom
annotated source: negative regulation of organelle organization
annotated property: has_exact_synonym
annotated target: negative regulation of organelle organisation
database_cross_reference: GOC:mah

Axiom
annotated source: negative regulation of organelle organization
annotated property: has_related_synonym
annotated target: negative regulation of organelle organization and biogenesis
database_cross_reference: GOC:mah

regulation of cell communication
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cell communication
subclass of: GO_0050794
subclass of: Restriction
  on property: regulates
  some values from: cell communication
definition: Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
has_obo_namespace: biological_process
id: GO:0010646

Axiom
annotated source: regulation of cell communication
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

positive regulation of cell communication
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: cell communication
subclass of: regulation of cell communication
subclass of: positive regulation of cellular process
subclass of: Restriction
  on property: positively regulates
  some values from: cell communication
definition: Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
has_obo_namespace: biological_process
id: GO:0010647

Axiom
annotated source: positive regulation of cell communication
annotated property: definition
annotated target: Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

negative regulation of cell communication
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cell communication
subclass of: regulation of cell communication
subclass of: negative regulation of cellular process
subclass of: Restriction
  on property: negatively regulates
  some values from: cell communication
definition: Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
has_obo_namespace: biological_process
id: GO:0010648

Axiom
annotated source: negative regulation of cell communication
annotated property: definition
annotated target: Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle
type: Class
equivalent class: Class
  intersection of: regulation of transcription by RNA polymerase II
  intersection of: Restriction
    on property: part of
    some values from: GO_0051321
subclass of: regulation of transcription by RNA polymerase II
subclass of: GO_0051037
definition: Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle.
created by: mah
creation date: 2012-04-20T02:45:12Z
has_alternative_id: GO:1900401
has_exact_synonym: regulation of transcription from RNA polymerase II promoter, meiotic
has_narrow_synonym: regulation of meiosis by regulation of transcription from RNA polymerase II promoter
has_obo_namespace: biological_process
id: GO:0010672

Axiom
annotated source: regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
database_cross_reference: PMID:12161753

Axiom
annotated source: regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle
annotated property: has_exact_synonym
annotated target: regulation of transcription from RNA polymerase II promoter, meiotic
database_cross_reference: GOC:mah

positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle
type: Class
equivalent class: Class
  intersection of: positive regulation of transcription by RNA polymerase II
  intersection of: Restriction
    on property: part of
    some values from: GO_0051321
subclass of: regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle
subclass of: positive regulation of transcription by RNA polymerase II
subclass of: GO_0051039
definition: Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle.
created by: dianna.fisk
creation date: 2012-05-01T08:40:11Z
has_alternative_id: GO:1900476
has_exact_synonym: positive regulation of transcription from RNA polymerase II promoter, meiotic
has_narrow_synonym: activation of meiosis by positive regulation of transcription from RNA polymerase II promoter
has_narrow_synonym: positive regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter
has_narrow_synonym: stimulation of meiosis by positive regulation of transcription from RNA polymerase II promoter
has_narrow_synonym: up regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter
has_narrow_synonym: up-regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter
has_narrow_synonym: upregulation of meiosis by positive regulation of transcription from RNA polymerase II promoter
has_obo_namespace: biological_process
id: GO:0010673

Axiom
annotated source: positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle
annotated property: definition
annotated target: Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
database_cross_reference: PMID:8618927

Axiom
annotated source: positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle
annotated property: has_exact_synonym
annotated target: positive regulation of transcription from RNA polymerase II promoter, meiotic
database_cross_reference: GOC:mah

Axiom
annotated source: positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle
annotated property: has_narrow_synonym
annotated target: activation of meiosis by positive regulation of transcription from RNA polymerase II promoter
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle
annotated property: has_narrow_synonym
annotated target: stimulation of meiosis by positive regulation of transcription from RNA polymerase II promoter
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle
annotated property: has_narrow_synonym
annotated target: up regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle
annotated property: has_narrow_synonym
annotated target: up-regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle
annotated property: has_narrow_synonym
annotated target: upregulation of meiosis by positive regulation of transcription from RNA polymerase II promoter
database_cross_reference: GOC:TermGenie

negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle
type: Class
equivalent class: Class
  intersection of: negative regulation of transcription by RNA polymerase II
  intersection of: Restriction
    on property: part of
    some values from: GO_0051321
subclass of: negative regulation of transcription by RNA polymerase II
subclass of: regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle
subclass of: GO_0051038
definition: Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle.
created by: dianna.fisk
creation date: 2012-05-01T08:39:58Z
has_alternative_id: GO:1900475
has_exact_synonym: negative regulation of transcription from RNA polymerase II promoter, meiotic
has_narrow_synonym: activation of meiosis by negative regulation of transcription from RNA polymerase II promoter
has_narrow_synonym: positive regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter
has_narrow_synonym: stimulation of meiosis by negative regulation of transcription from RNA polymerase II promoter
has_narrow_synonym: up regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter
has_narrow_synonym: up-regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter
has_narrow_synonym: upregulation of meiosis by negative regulation of transcription from RNA polymerase II promoter
has_obo_namespace: biological_process
id: GO:0010674

Axiom
annotated source: negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle
annotated property: definition
annotated target: Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
database_cross_reference: PMID:8618927

Axiom
annotated source: negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle
annotated property: has_exact_synonym
annotated target: negative regulation of transcription from RNA polymerase II promoter, meiotic
database_cross_reference: GOC:mah

Axiom
annotated source: negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle
annotated property: has_narrow_synonym
annotated target: activation of meiosis by negative regulation of transcription from RNA polymerase II promoter
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle
annotated property: has_narrow_synonym
annotated target: stimulation of meiosis by negative regulation of transcription from RNA polymerase II promoter
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle
annotated property: has_narrow_synonym
annotated target: up regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle
annotated property: has_narrow_synonym
annotated target: up-regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle
annotated property: has_narrow_synonym
annotated target: upregulation of meiosis by negative regulation of transcription from RNA polymerase II promoter
database_cross_reference: GOC:TermGenie

positive regulation of cell development
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: cell development
subclass of: positive regulation of cell differentiation
subclass of: GO_0060284
subclass of: Restriction
  on property: positively regulates
  some values from: cell development
definition: Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
has_obo_namespace: biological_process
id: GO:0010720

Axiom
annotated source: positive regulation of cell development
annotated property: definition
annotated target: Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

negative regulation of cell development
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cell development
subclass of: negative regulation of cell differentiation
subclass of: GO_0060284
subclass of: Restriction
  on property: negatively regulates
  some values from: cell development
definition: Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
has_obo_namespace: biological_process
id: GO:0010721

Axiom
annotated source: negative regulation of cell development
annotated property: definition
annotated target: Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
type: Class
subclass of: cellular response to DNA damage stimulus
subclass of: cellular response to UV
subclass of: regulation of transcription from RNA polymerase II promoter in response to stress
definition: Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus.
has_obo_namespace: biological_process
id: GO:0010767

Axiom
annotated source: regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
type: Class
subclass of: negative regulation of transcription by RNA polymerase II
subclass of: regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
definition: Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus.
has_obo_namespace: biological_process
id: GO:0010768

Axiom
annotated source: negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
annotated property: definition
annotated target: Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

regulation of mitochondrion organization
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: mitochondrion organization
subclass of: regulation of organelle organization
subclass of: Restriction
  on property: regulates
  some values from: mitochondrion organization
definition: Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion.
has_exact_synonym: regulation of mitochondrion organisation
has_obo_namespace: biological_process
id: GO:0010821

Axiom
annotated source: regulation of mitochondrion organization
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

Axiom
annotated source: regulation of mitochondrion organization
annotated property: has_exact_synonym
annotated target: regulation of mitochondrion organisation
database_cross_reference: GOC:mah

positive regulation of mitochondrion organization
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: mitochondrion organization
subclass of: positive regulation of organelle organization
subclass of: regulation of mitochondrion organization
subclass of: Restriction
  on property: positively regulates
  some values from: mitochondrion organization
definition: Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion.
has_exact_synonym: positive regulation of mitochondrion organisation
has_obo_namespace: biological_process
id: GO:0010822

Axiom
annotated source: positive regulation of mitochondrion organization
annotated property: definition
annotated target: Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

Axiom
annotated source: positive regulation of mitochondrion organization
annotated property: has_exact_synonym
annotated target: positive regulation of mitochondrion organisation
database_cross_reference: GOC:mah

negative regulation of mitochondrion organization
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: mitochondrion organization
subclass of: negative regulation of organelle organization
subclass of: regulation of mitochondrion organization
subclass of: Restriction
  on property: negatively regulates
  some values from: mitochondrion organization
definition: Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion.
has_exact_synonym: negative regulation of mitochondrion organisation
has_obo_namespace: biological_process
id: GO:0010823

Axiom
annotated source: negative regulation of mitochondrion organization
annotated property: definition
annotated target: Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

Axiom
annotated source: negative regulation of mitochondrion organization
annotated property: has_exact_synonym
annotated target: negative regulation of mitochondrion organisation
database_cross_reference: GOC:mah

cellular component assembly involved in morphogenesis
type: Class
equivalent class: Class
  intersection of: cellular component assembly
  intersection of: Restriction
    on property: part of
    some values from: anatomical structure morphogenesis
subclass of: cellular component assembly
subclass of: anatomical structure formation involved in morphogenesis
subclass of: Restriction
  on property: part of
  some values from: cellular component morphogenesis
definition: The cellular component assembly that is part of the initial shaping of the component during its developmental progression.
has_obo_namespace: biological_process
id: GO:0010927

Axiom
annotated source: cellular component assembly involved in morphogenesis
annotated property: definition
annotated target: The cellular component assembly that is part of the initial shaping of the component during its developmental progression.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

regulation of cell death
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cell death
subclass of: GO_0050794
subclass of: Restriction
  on property: regulates
  some values from: cell death
definition: Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
has_obo_namespace: biological_process
id: GO:0010941

Axiom
annotated source: regulation of cell death
annotated property: definition
annotated target: Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

positive regulation of cell death
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: cell death
subclass of: regulation of cell death
subclass of: positive regulation of cellular process
subclass of: Restriction
  on property: positively regulates
  some values from: cell death
definition: Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
has_obo_namespace: biological_process
id: GO:0010942

Axiom
annotated source: positive regulation of cell death
annotated property: definition
annotated target: Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

negative regulation of cell cycle process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cell cycle process
subclass of: regulation of cell cycle process
subclass of: negative regulation of cell cycle
subclass of: Restriction
  on property: negatively regulates
  some values from: cell cycle process
definition: Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
created by: tanyaberardini
creation date: 2009-04-27T09:53:22Z
has_obo_namespace: biological_process
id: GO:0010948

Axiom
annotated source: negative regulation of cell cycle process
annotated property: definition
annotated target: Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

positive regulation of peptidase activity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: peptidase activity
subclass of: positive regulation of proteolysis
subclass of: GO_0051345
subclass of: GO_0052547
subclass of: Restriction
  on property: positively regulates
  some values from: peptidase activity
definition: Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins.
created by: tanyaberardini
creation date: 2009-04-27T11:54:32Z
has_obo_namespace: biological_process
id: GO:0010952

Axiom
annotated source: positive regulation of peptidase activity
annotated property: definition
annotated target: Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

magnesium ion homeostasis
type: Class
subclass of: GO_0055065
subclass of: GO_0072507
definition: Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell.
created by: tanyaberardini
creation date: 2009-05-06T11:47:17Z
has_obo_namespace: biological_process
id: GO:0010960

Axiom
annotated source: magnesium ion homeostasis
annotated property: definition
annotated target: Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

transport along microtubule
type: Class
subclass of: cytoskeleton-dependent intracellular transport
subclass of: GO_0099111
definition: The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity.
created by: tanyaberardini
creation date: 2009-05-27T10:56:08Z
has_broad_synonym: microtubule-based transport
has_exact_synonym: establishment of localization by movement along microtubule
has_exact_synonym: movement along microtubule
has_obo_namespace: biological_process
id: GO:0010970

Axiom
annotated source: transport along microtubule
annotated property: definition
annotated target: The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity.
database_cross_reference: GOC:dph
database_cross_reference: GOC:mah
database_cross_reference: GOC:tb

Axiom
annotated source: transport along microtubule
annotated property: has_exact_synonym
annotated target: establishment of localization by movement along microtubule
database_cross_reference: GOC:dph

regulation of neuron projection development
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: neuron projection development
subclass of: regulation of neuron differentiation
subclass of: GO_0120035
subclass of: Restriction
  on property: regulates
  some values from: neuron projection development
definition: Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
created by: tanyaberardini
creation date: 2009-06-01T10:44:45Z
has_narrow_synonym: regulation of neurite biosynthesis
has_narrow_synonym: regulation of neurite development
has_narrow_synonym: regulation of neurite formation
has_narrow_synonym: regulation of neurite growth
has_obo_namespace: biological_process
id: GO:0010975

Axiom
annotated source: regulation of neuron projection development
annotated property: definition
annotated target: Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

Axiom
annotated source: regulation of neuron projection development
annotated property: has_narrow_synonym
annotated target: regulation of neurite biosynthesis
database_cross_reference: GOC:mah

Axiom
annotated source: regulation of neuron projection development
annotated property: has_narrow_synonym
annotated target: regulation of neurite development
database_cross_reference: GOC:mah

Axiom
annotated source: regulation of neuron projection development
annotated property: has_narrow_synonym
annotated target: regulation of neurite formation
database_cross_reference: GOC:mah

Axiom
annotated source: regulation of neuron projection development
annotated property: has_narrow_synonym
annotated target: regulation of neurite growth
database_cross_reference: GOC:mah

positive regulation of neuron projection development
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: neuron projection development
subclass of: regulation of neuron projection development
subclass of: positive regulation of cell projection organization
subclass of: positive regulation of neuron differentiation
subclass of: Restriction
  on property: positively regulates
  some values from: neuron projection development
definition: Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
created by: tanyaberardini
creation date: 2009-06-01T10:46:44Z
has_narrow_synonym: positive regulation of neurite biosynthesis
has_narrow_synonym: positive regulation of neurite development
has_narrow_synonym: positive regulation of neurite formation
has_narrow_synonym: positive regulation of neurite growth
has_obo_namespace: biological_process
id: GO:0010976

Axiom
annotated source: positive regulation of neuron projection development
annotated property: definition
annotated target: Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

Axiom
annotated source: positive regulation of neuron projection development
annotated property: has_narrow_synonym
annotated target: positive regulation of neurite biosynthesis
database_cross_reference: GOC:mah

Axiom
annotated source: positive regulation of neuron projection development
annotated property: has_narrow_synonym
annotated target: positive regulation of neurite development
database_cross_reference: GOC:mah

Axiom
annotated source: positive regulation of neuron projection development
annotated property: has_narrow_synonym
annotated target: positive regulation of neurite formation
database_cross_reference: GOC:mah

Axiom
annotated source: positive regulation of neuron projection development
annotated property: has_narrow_synonym
annotated target: positive regulation of neurite growth
database_cross_reference: GOC:mah

negative regulation of neuron projection development
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: neuron projection development
subclass of: regulation of neuron projection development
subclass of: negative regulation of cell projection organization
subclass of: negative regulation of neuron differentiation
subclass of: Restriction
  on property: negatively regulates
  some values from: neuron projection development
definition: Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
created by: tanyaberardini
creation date: 2009-06-01T10:47:42Z
has_narrow_synonym: negative regulation of neurite biosynthesis
has_narrow_synonym: negative regulation of neurite development
has_narrow_synonym: negative regulation of neurite formation
has_narrow_synonym: negative regulation of neurite growth
has_obo_namespace: biological_process
has_related_synonym: growth cone collapse
id: GO:0010977

Axiom
annotated source: negative regulation of neuron projection development
annotated property: definition
annotated target: Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

Axiom
annotated source: negative regulation of neuron projection development
annotated property: has_narrow_synonym
annotated target: negative regulation of neurite biosynthesis
database_cross_reference: GOC:mah

Axiom
annotated source: negative regulation of neuron projection development
annotated property: has_narrow_synonym
annotated target: negative regulation of neurite development
database_cross_reference: GOC:mah

Axiom
annotated source: negative regulation of neuron projection development
annotated property: has_narrow_synonym
annotated target: negative regulation of neurite formation
database_cross_reference: GOC:mah

Axiom
annotated source: negative regulation of neuron projection development
annotated property: has_narrow_synonym
annotated target: negative regulation of neurite growth
database_cross_reference: GOC:mah

Axiom
annotated source: negative regulation of neuron projection development
annotated property: has_related_synonym
annotated target: growth cone collapse
database_cross_reference: GOC:pr

programmed cell death
type: Class
subclass of: cell death
definition: A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
has_alternative_id: GO:0016244
has_broad_synonym: regulated cell death
database_cross_reference: Wikipedia:Programmed_cell_death
has_narrow_synonym: caspase-independent cell death
has_narrow_synonym: non-apoptotic programmed cell death
has_narrow_synonym: nonapoptotic programmed cell death
has_obo_namespace: biological_process
has_related_synonym: PCD
has_related_synonym: RCD
has_related_synonym: caspase-independent apoptosis
id: GO:0012501
comment: Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children.

Axiom
annotated source: programmed cell death
annotated property: definition
annotated target: A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
database_cross_reference: GOC:lr
database_cross_reference: GOC:mtg_apoptosis

endomembrane system
type: Class
subclass of: GO_0110165
subclass of: Restriction
  on property: has part
  some values from: vacuole
subclass of: Restriction
  on property: has part
  some values from: plasma membrane
definition: A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
database_cross_reference: Wikipedia:Endomembrane_system
has_obo_namespace: cellular_component
id: GO:0012505
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim flybase ribbon
in_subset: goslim yeast

Axiom
annotated source: endomembrane system
annotated property: definition
annotated target: A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
database_cross_reference: GOC:lh

vesicle membrane
type: Class
subclass of: organelle membrane
subclass of: Restriction
  on property: part of
  some values from: vesicle
definition: The lipid bilayer surrounding any membrane-bounded vesicle in the cell.
database_cross_reference: NIF_Subcellular:sao1153182838
has_obo_namespace: cellular_component
id: GO:0012506

Axiom
annotated source: vesicle membrane
annotated property: definition
annotated target: The lipid bilayer surrounding any membrane-bounded vesicle in the cell.
database_cross_reference: GOC:mah
database_cross_reference: GOC:vesicle

ER to Golgi transport vesicle membrane
type: Class
subclass of: transport vesicle membrane
subclass of: Golgi-associated vesicle membrane
subclass of: coated vesicle membrane
subclass of: Restriction
  on property: part of
  some values from: COPII-coated ER to Golgi transport vesicle
definition: The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi.
has_alternative_id: GO:0030664
has_exact_synonym: COPII coated vesicle membrane
has_exact_synonym: ER to Golgi constitutive secretory pathway transport vesicle membrane
has_exact_synonym: ER-Golgi transport vesicle membrane
has_exact_synonym: endoplasmic reticulum to Golgi transport vesicle membrane
has_exact_synonym: endoplasmic reticulum-Golgi transport vesicle membrane
has_obo_namespace: cellular_component
id: GO:0012507

Axiom
annotated source: ER to Golgi transport vesicle membrane
annotated property: definition
annotated target: The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi.
database_cross_reference: GOC:ai
database_cross_reference: GOC:ascb_2009
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

monolayer-surrounded lipid storage body
type: Class
subclass of: lipid droplet
definition: A subcellular organelle of plant cells surrounded by 'half-unit' or a monolayer membrane instead of the more usual bilayer. The storage body has a droplet of triglyceride surrounded by a monolayer of phospholipids, interacting with the triglycerides and the hydrophilic head groups facing the cytosol, and containing major protein components called oleosins.
has_alternative_id: GO:0009520
database_cross_reference: Wikipedia:Oil_body
has_exact_synonym: oil body
has_exact_synonym: oilbody
has_exact_synonym: oleosome
has_exact_synonym: spherosome
has_obo_namespace: cellular_component
id: GO:0012511

Axiom
annotated source: monolayer-surrounded lipid storage body
annotated property: definition
annotated target: A subcellular organelle of plant cells surrounded by 'half-unit' or a monolayer membrane instead of the more usual bilayer. The storage body has a droplet of triglyceride surrounded by a monolayer of phospholipids, interacting with the triglycerides and the hydrophilic head groups facing the cytosol, and containing major protein components called oleosins.
database_cross_reference: GOC:mtg_sensu
database_cross_reference: ISBN:0943088372

regulation of neuron maturation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: neuron maturation
subclass of: regulation of neuron differentiation
subclass of: GO_1903429
subclass of: Restriction
  on property: regulates
  some values from: neuron maturation
definition: Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change.
has_obo_namespace: biological_process
id: GO:0014041

Axiom
annotated source: regulation of neuron maturation
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change.
database_cross_reference: GOC:ef

positive regulation of neuron maturation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: neuron maturation
subclass of: regulation of neuron maturation
subclass of: positive regulation of neuron differentiation
subclass of: GO_1903431
subclass of: Restriction
  on property: positively regulates
  some values from: neuron maturation
definition: Any process that activates or increases the frequency, rate or extent of neuron maturation.
has_exact_synonym: up regulation of neuron maturation
has_exact_synonym: up-regulation of neuron maturation
has_exact_synonym: upregulation of neuron maturation
has_narrow_synonym: activation of neuron maturation
has_narrow_synonym: stimulation of neuron maturation
has_obo_namespace: biological_process
id: GO:0014042

Axiom
annotated source: positive regulation of neuron maturation
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of neuron maturation.
database_cross_reference: GOC:ef

negative regulation of neuron maturation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: neuron maturation
subclass of: regulation of neuron maturation
subclass of: negative regulation of neuron differentiation
subclass of: GO_1903430
subclass of: Restriction
  on property: negatively regulates
  some values from: neuron maturation
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation.
has_exact_synonym: down regulation of neuron maturation
has_exact_synonym: down-regulation of neuron maturation
has_exact_synonym: downregulation of neuron maturation
has_narrow_synonym: inhibition of neuron maturation
has_obo_namespace: biological_process
id: GO:0014043

Axiom
annotated source: negative regulation of neuron maturation
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation.
database_cross_reference: GOC:ef

postsynaptic density
type: Class
equivalent class: Class
  intersection of: GO_0099572
  intersection of: Restriction
    on property: part of
    some values from: asymmetric synapse
subclass of: GO_0099572
subclass of: Restriction
  on property: part of
  some values from: asymmetric synapse
definition: An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
created by: paola
creation date: 2013-07-02T09:44:28Z
has_alternative_id: GO:0097481
has_alternative_id: GO:0097483
database_cross_reference: NIF_Subcellular:sao1196688972
database_cross_reference: Wikipedia:Postsynaptic_density
has_exact_synonym: neuronal postsynaptic density
has_exact_synonym: post synaptic density
has_exact_synonym: post-synaptic density
has_narrow_synonym: postsynaptic density of dendrite
has_obo_namespace: cellular_component
id: GO:0014069
in_subset: goslim synapse

Axiom
annotated source: postsynaptic density
annotated property: definition
annotated target: An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:dos
database_cross_reference: GOC:ef
database_cross_reference: GOC:jid
database_cross_reference: GOC:pr
database_cross_reference: GOC:sjp
database_cross_reference: PMID:14532281
database_cross_reference: Wikipedia:Postsynaptic_density
database_cross_reference: http://molneuro.kaist.ac.kr/psd

Axiom
annotated source: postsynaptic density
annotated property: has_exact_synonym
annotated target: neuronal postsynaptic density
database_cross_reference: GO:0097481

response to organic cyclic compound
type: Class
subclass of: response to organic substance
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
has_exact_synonym: response to organic cyclic substance
has_obo_namespace: biological_process
id: GO:0014070

Axiom
annotated source: response to organic cyclic compound
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
database_cross_reference: GOC:ef

Axiom
annotated source: response to organic cyclic compound
annotated property: has_exact_synonym
annotated target: response to organic cyclic substance
database_cross_reference: GOC:mah

response to isoquinoline alkaloid
type: Class
subclass of: response to organic cyclic compound
subclass of: response to alkaloid
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids.
has_obo_namespace: biological_process
id: GO:0014072

Axiom
annotated source: response to isoquinoline alkaloid
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids.
database_cross_reference: GOC:ef

response to amine
type: Class
subclass of: response to organonitrogen compound
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.
has_exact_synonym: response to amine stimulus
has_obo_namespace: biological_process
id: GO:0014075

Axiom
annotated source: response to amine
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.
database_cross_reference: GOC:ef

Axiom
annotated source: response to amine
annotated property: has_exact_synonym
annotated target: response to amine stimulus
database_cross_reference: GOC:dos

protein transport
type: Class
subclass of: peptide transport
subclass of: establishment of protein localization
definition: The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has_alternative_id: GO:0015831
has_narrow_synonym: enzyme transport
has_obo_namespace: biological_process
id: GO:0015031
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: protein transport
annotated property: definition
annotated target: The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
database_cross_reference: GOC:ai

ion transmembrane transporter activity
type: Class
subclass of: transmembrane transporter activity
subclass of: Restriction
  on property: part of
  some values from: ion transmembrane transport
definition: Enables the transfer of an ion from one side of a membrane to the other.
has_exact_synonym: ion transporter activity
has_obo_namespace: molecular_function
id: GO:0015075

Axiom
annotated source: ion transmembrane transporter activity
annotated property: definition
annotated target: Enables the transfer of an ion from one side of a membrane to the other.
database_cross_reference: GOC:dgf
database_cross_reference: GOC:mtg_transport
database_cross_reference: ISBN:0815340729

GO_0015238
type: Class
IAO_0000231: IAO_0000227
term replaced by: xenobiotic transmembrane transporter activity
deprecated: true

inorganic molecular entity transmembrane transporter activity
type: Class
subclass of: transmembrane transporter activity
definition: Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon.
IAO_0000233: https://github.com/geneontology/go-ontology/issues/14372
has_exact_synonym: inorganic solute uptake transmembrane transporter activity
has_exact_synonym: inorganic uptake permease activity
has_obo_namespace: molecular_function
id: GO:0015318
in_subset: gocheck do not annotate

Axiom
annotated source: inorganic molecular entity transmembrane transporter activity
annotated property: definition
annotated target: Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon.
database_cross_reference: GOC:mtg_transport
database_cross_reference: ISBN:0815340729

microtubule cytoskeleton
type: Class
subclass of: cytoskeleton
definition: The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
has_obo_namespace: cellular_component
id: GO:0015630
in_subset: goslim aspergillus

Axiom
annotated source: microtubule cytoskeleton
annotated property: definition
annotated target: The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0395825172

organic anion transport
type: Class
subclass of: anion transport
subclass of: GO_0071702
definition: The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.
has_obo_namespace: biological_process
id: GO:0015711

Axiom
annotated source: organic anion transport
annotated property: definition
annotated target: The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.
database_cross_reference: GOC:ai
database_cross_reference: GOC:krc

peptide transport
type: Class
subclass of: amide transport
subclass of: GO_0071702
definition: The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has_obo_namespace: biological_process
id: GO:0015833
in_subset: goslim pir

Axiom
annotated source: peptide transport
annotated property: definition
annotated target: The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
database_cross_reference: GOC:ai

organic acid transport
type: Class
subclass of: GO_0071702
definition: The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has_obo_namespace: biological_process
id: GO:0015849
in_subset: goslim pir

Axiom
annotated source: organic acid transport
annotated property: definition
annotated target: The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
database_cross_reference: ISBN:0198506732

folic acid transport
type: Class
subclass of: dicarboxylic acid transport
subclass of: drug transport
subclass of: amide transport
subclass of: GO_0051180
subclass of: GO_0051181
subclass of: GO_0072337
definition: The directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
has_exact_synonym: folate transport
has_exact_synonym: vitamin B9 transport
has_exact_synonym: vitamin M transport
has_obo_namespace: biological_process
id: GO:0015884

Axiom
annotated source: folic acid transport
annotated property: definition
annotated target: The directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
database_cross_reference: GOC:ai

drug transport
type: Class
subclass of: transport
subclass of: Restriction
  on property: part of
  some values from: response to drug
definition: The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has_obo_namespace: biological_process
id: GO:0015893
in_subset: goslim pir

Axiom
annotated source: drug transport
annotated property: definition
annotated target: The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
database_cross_reference: GOC:ai

pantothenate metabolic process
type: Class
subclass of: cellular modified amino acid metabolic process
subclass of: coenzyme metabolic process
subclass of: water-soluble vitamin metabolic process
subclass of: monocarboxylic acid metabolic process
subclass of: cellular amide metabolic process
definition: The chemical reactions and pathways involving pantothenate, the anion of pantothenic acid, the amide of beta-alanine and pantoic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods.
has_alternative_id: GO:0006770
has_exact_synonym: pantothenate metabolism
has_exact_synonym: vitamin B5 metabolic process
has_exact_synonym: vitamin B5 metabolism
has_obo_namespace: biological_process
id: GO:0015939

Axiom
annotated source: pantothenate metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving pantothenate, the anion of pantothenic acid, the amide of beta-alanine and pantoic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods.
database_cross_reference: GOC:ai
database_cross_reference: ISBN:0721662544

membrane
type: Class
subclass of: anatomical structure
subclass of: GO_0110165
definition: A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
imported from: go.owl
database_cross_reference: Wikipedia:Biological_membrane
has_obo_namespace: cellular_component
id: GO:0016020
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

Axiom
annotated source: membrane
annotated property: definition
annotated target: A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
database_cross_reference: GOC:dos
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0815316194

GO_0016023
type: Class
IAO_0000231: IAO_0000227
term replaced by: cytoplasmic vesicle
deprecated: true

cellular component organization
type: Class
subclass of: GO_0071840
definition: A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.
has_alternative_id: GO:0044235
has_alternative_id: GO:0071842
database_cross_reference: MIPS_funcat:42
has_exact_synonym: cell organisation
has_exact_synonym: cellular component organisation at cellular level
has_exact_synonym: cellular component organisation in other organism
has_exact_synonym: cellular component organization at cellular level
has_exact_synonym: cellular component organization in other organism
has_obo_namespace: biological_process
has_related_synonym: cell organization and biogenesis
id: GO:0016043
in_subset: goslim agr
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant

Axiom
annotated source: cellular component organization
annotated property: definition
annotated target: A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.
database_cross_reference: GOC:ai
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Axiom
annotated source: cellular component organization
annotated property: has_exact_synonym
annotated target: cellular component organisation at cellular level
database_cross_reference: GOC:mah

Axiom
annotated source: cellular component organization
annotated property: has_exact_synonym
annotated target: cellular component organisation in other organism
database_cross_reference: GOC:mah

Axiom
annotated source: cellular component organization
annotated property: has_related_synonym
annotated target: cell organization and biogenesis
database_cross_reference: GOC:mah

cell growth
type: Class
subclass of: cellular process
subclass of: growth
definition: The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
has_alternative_id: GO:0048591
has_exact_synonym: cellular growth
has_exact_synonym: growth of cell
has_obo_namespace: biological_process
has_related_synonym: cell expansion
has_related_synonym: metabolic process resulting in cell growth
has_related_synonym: metabolism resulting in cell growth
has_related_synonym: non-developmental cell growth
has_related_synonym: non-developmental growth of a unicellular organism
id: GO:0016049
in_subset: gocheck do not annotate
in_subset: goslim drosophila
in_subset: goslim pir
in_subset: goslim plant

Axiom
annotated source: cell growth
annotated property: definition
annotated target: The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
database_cross_reference: GOC:ai

Axiom
annotated source: cell growth
annotated property: has_related_synonym
annotated target: non-developmental cell growth
database_cross_reference: GOC:mah

Axiom
annotated source: cell growth
annotated property: has_related_synonym
annotated target: non-developmental growth of a unicellular organism
database_cross_reference: GOC:mah

vesicle organization
type: Class
subclass of: organelle organization
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle.
has_exact_synonym: vesicle organisation
has_obo_namespace: biological_process
has_related_synonym: vesicle organization and biogenesis
id: GO:0016050
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: vesicle organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle.
database_cross_reference: GOC:mah

Axiom
annotated source: vesicle organization
annotated property: has_related_synonym
annotated target: vesicle organization and biogenesis
database_cross_reference: GOC:mah

rhodopsin mediated signaling pathway
type: Class
subclass of: G protein-coupled receptor signaling pathway
subclass of: phototransduction
subclass of: GO_0071482
subclass of: Restriction
  on property: part of
  some values from: phototransduction, visible light
definition: The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events that convert the absorbed photons into a cellular response.
has_alternative_id: GO:0009586
has_exact_synonym: rhodopsin mediated phototransduction
has_exact_synonym: rhodopsin mediated signalling pathway
has_exact_synonym: rhodopsin signaling
has_obo_namespace: biological_process
id: GO:0016056

Axiom
annotated source: rhodopsin mediated signaling pathway
annotated property: definition
annotated target: The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events that convert the absorbed photons into a cellular response.
database_cross_reference: GOC:bf
database_cross_reference: GOC:dph
database_cross_reference: GOC:hb
database_cross_reference: GOC:signaling
database_cross_reference: GOC:tb

Axiom
annotated source: rhodopsin mediated signaling pathway
annotated property: has_exact_synonym
annotated target: rhodopsin mediated phototransduction
database_cross_reference: GOC:bf

Axiom
annotated source: rhodopsin mediated signaling pathway
annotated property: has_exact_synonym
annotated target: rhodopsin mediated signalling pathway
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

Axiom
annotated source: rhodopsin mediated signaling pathway
annotated property: has_exact_synonym
annotated target: rhodopsin signaling
database_cross_reference: GOC:bf

immunoglobulin mediated immune response
type: Class
subclass of: B cell mediated immunity
definition: An immune response mediated by immunoglobulins, whether cell-bound or in solution.
has_exact_synonym: antibody-mediated immune response
has_obo_namespace: biological_process
id: GO:0016064

Axiom
annotated source: immunoglobulin mediated immune response
annotated property: definition
annotated target: An immune response mediated by immunoglobulins, whether cell-bound or in solution.
database_cross_reference: GOC:add
database_cross_reference: GO_REF:0000022
database_cross_reference: ISBN:0781735149

RNA metabolic process
type: Class
subclass of: GO_0090304
definition: The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
has_exact_synonym: RNA metabolism
has_obo_namespace: biological_process
id: GO:0016070
in_subset: goslim agr
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim metagenomics
in_subset: goslim pir

Axiom
annotated source: RNA metabolic process
annotated property: definition
annotated target: The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
database_cross_reference: ISBN:0198506732

diterpenoid metabolic process
type: Class
subclass of: terpenoid metabolic process
definition: The chemical reactions and pathways involving diterpenoid compounds, terpenoids with four isoprene units.
has_exact_synonym: diterpenoid metabolism
has_narrow_synonym: diterpene metabolic process
has_narrow_synonym: diterpene metabolism
has_obo_namespace: biological_process
id: GO:0016101

Axiom
annotated source: diterpenoid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving diterpenoid compounds, terpenoids with four isoprene units.
database_cross_reference: ISBN:0198547684

carotene metabolic process
type: Class
subclass of: terpene metabolic process
definition: The chemical reactions and pathways involving carotenes, hydrocarbon carotenoids.
has_exact_synonym: carotene metabolism
has_obo_namespace: biological_process
id: GO:0016119

Axiom
annotated source: carotene metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving carotenes, hydrocarbon carotenoids.
database_cross_reference: ISBN:0198547684

vesicle-mediated transport
type: Class
subclass of: transport
subclass of: cellular process
definition: A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
has_alternative_id: GO:0006899
has_exact_synonym: vesicle transport
has_exact_synonym: vesicular transport
has_narrow_synonym: nonselective vesicle transport
has_obo_namespace: biological_process
has_related_synonym: protein sorting along secretory pathway
has_related_synonym: vesicle trafficking
id: GO:0016192
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe

Axiom
annotated source: vesicle-mediated transport
annotated property: definition
annotated target: A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
database_cross_reference: GOC:ai
database_cross_reference: GOC:mah
database_cross_reference: ISBN:08789310662000

Axiom
annotated source: vesicle-mediated transport
annotated property: has_exact_synonym
annotated target: vesicular transport
database_cross_reference: GOC:mah

macroautophagy
type: Class
subclass of: autophagy
definition: The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded.
has_alternative_id: GO:0034262
has_broad_synonym: autophagy
has_obo_namespace: biological_process
id: GO:0016236
comment: Targeted macroautophagy sometimes targets regions of cytoplasm containing non-self, such as virus particles or components (e.g. see PMID:20159618). As this is essentially the same process as macroautophagy that encloses and digests only self, the term autophagy is still used despite the enclosure of some non-self (non-auto) entities.

Axiom
annotated source: macroautophagy
annotated property: definition
annotated target: The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded.
database_cross_reference: PMID:11099404
database_cross_reference: PMID:12914914
database_cross_reference: PMID:15798367
database_cross_reference: PMID:16973210
database_cross_reference: PMID:20159618
database_cross_reference: PMID:9412464

positive regulation of macroautophagy
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: macroautophagy
subclass of: positive regulation of autophagy
subclass of: regulation of macroautophagy
subclass of: Restriction
  on property: positively regulates
  some values from: macroautophagy
definition: Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation.
has_exact_synonym: positive regulation of starvation-induced autophagy
has_exact_synonym: up regulation of macroautophagy
has_exact_synonym: up-regulation of macroautophagy
has_exact_synonym: upregulation of macroautophagy
has_narrow_synonym: activation of macroautophagy
has_narrow_synonym: stimulation of macroautophagy
has_obo_namespace: biological_process
id: GO:0016239

Axiom
annotated source: positive regulation of macroautophagy
annotated property: definition
annotated target: Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation.
database_cross_reference: GOC:go_curators
database_cross_reference: PMID:9412464

Axiom
annotated source: positive regulation of macroautophagy
annotated property: has_exact_synonym
annotated target: positive regulation of starvation-induced autophagy
database_cross_reference: GOC:ascb_2009
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

regulation of macroautophagy
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: macroautophagy
subclass of: regulation of autophagy
subclass of: Restriction
  on property: regulates
  some values from: macroautophagy
definition: Any process that modulates the frequency, rate or extent of macroautophagy.
has_exact_synonym: regulation of starvation-induced autophagy
has_obo_namespace: biological_process
id: GO:0016241

Axiom
annotated source: regulation of macroautophagy
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of macroautophagy.
database_cross_reference: GOC:krc

Axiom
annotated source: regulation of macroautophagy
annotated property: has_exact_synonym
annotated target: regulation of starvation-induced autophagy
database_cross_reference: GOC:ascb_2009
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

negative regulation of macroautophagy
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: macroautophagy
subclass of: negative regulation of autophagy
subclass of: regulation of macroautophagy
subclass of: Restriction
  on property: negatively regulates
  some values from: macroautophagy
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy.
has_exact_synonym: down regulation of macroautophagy
has_exact_synonym: down-regulation of macroautophagy
has_exact_synonym: downregulation of macroautophagy
has_exact_synonym: negative regulation of starvation-induced autophagy
has_narrow_synonym: inhibition of macroautophagy
has_obo_namespace: biological_process
id: GO:0016242

Axiom
annotated source: negative regulation of macroautophagy
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy.
database_cross_reference: GOC:go_curators

Axiom
annotated source: negative regulation of macroautophagy
annotated property: has_exact_synonym
annotated target: negative regulation of starvation-induced autophagy
database_cross_reference: GOC:ascb_2009
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

RNA interference
type: Class
subclass of: posttranscriptional gene silencing by RNA
definition: The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes.
never in taxon: NCBITaxon 4895
database_cross_reference: Wikipedia:RNA_interference
has_exact_synonym: RNAi
has_exact_synonym: posttranscriptional gene silencing by siRNA
has_obo_namespace: biological_process
id: GO:0016246
comment: Note that this term refers specifically to posttranscriptional mechanisms by which small interfering RNAs down-regulate gene expression. Also consider annotating to other descendants of 'gene silencing by RNA ; GO:0031047'.

Axiom
annotated source: RNA interference
annotated property: definition
annotated target: The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes.
database_cross_reference: GOC:ems
database_cross_reference: PMID:11201747
database_cross_reference: PMID:11713190
database_cross_reference: PMID:18771919

Axiom
annotated source: RNA interference
annotated property: has_exact_synonym
annotated target: posttranscriptional gene silencing by siRNA
database_cross_reference: GOC:mah

kinase activity
type: Class
subclass of: transferase activity, transferring phosphorus-containing groups
subclass of: Restriction
  on property: part of
  some values from: phosphorylation
subclass of: Restriction
  on property: is kinase activity
  has self: true
definition: Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
database_cross_reference: Reactome:R-HSA-6788855
database_cross_reference: Reactome:R-HSA-6788867
has_exact_synonym: phosphokinase activity
has_obo_namespace: molecular_function
id: GO:0016301
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim plant
in_subset: goslim yeast
comment: Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term.

Axiom
annotated source: kinase activity
annotated property: definition
annotated target: Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
database_cross_reference: ISBN:0198506732

FN3KRP phosphorylates PsiAm, RibAm
type: Axiom
annotated source: kinase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6788855

FN3K phosphorylates ketosamines
type: Axiom
annotated source: kinase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6788867

phosphorylation
type: Class
subclass of: phosphate-containing compound metabolic process
definition: The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
database_cross_reference: Wikipedia:Phosphorylation
has_obo_namespace: biological_process
id: GO:0016310
in_subset: goslim chembl
in_subset: goslim metagenomics

Axiom
annotated source: phosphorylation
annotated property: definition
annotated target: The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
database_cross_reference: ISBN:0198506732

female meiosis chromosome segregation
type: Class
equivalent class: Class
  intersection of: GO_0098813
  intersection of: Restriction
    on property: part of
    some values from: female meiotic nuclear division
subclass of: cellular process involved in reproduction in multicellular organism
subclass of: meiotic chromosome segregation
subclass of: Restriction
  on property: part of
  some values from: female meiotic nuclear division
definition: The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female.
has_obo_namespace: biological_process
id: GO:0016321

Axiom
annotated source: female meiosis chromosome segregation
annotated property: definition
annotated target: The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female.
database_cross_reference: GOC:ai

posttranscriptional gene silencing
type: Class
subclass of: posttranscriptional regulation of gene expression
subclass of: gene silencing
subclass of: regulation of gene expression, epigenetic
definition: The inactivation of gene expression by a posttranscriptional mechanism.
database_cross_reference: Wikipedia:Post_transcriptional_gene_silencing
has_exact_synonym: PTGS
has_exact_synonym: post-transcriptional gene silencing
has_exact_synonym: quelling
has_obo_namespace: biological_process
has_related_synonym: cosuppression
id: GO:0016441

Axiom
annotated source: posttranscriptional gene silencing
annotated property: definition
annotated target: The inactivation of gene expression by a posttranscriptional mechanism.
database_cross_reference: GOC:mah
database_cross_reference: PMID:15020054

Axiom
annotated source: posttranscriptional gene silencing
annotated property: has_exact_synonym
annotated target: post-transcriptional gene silencing
database_cross_reference: GOC:vw

gene silencing
type: Class
subclass of: cellular process
subclass of: negative regulation of gene expression
definition: Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression.
database_cross_reference: Wikipedia:Gene_silencing
has_narrow_synonym: long-term maintenance of gene inactivation
has_obo_namespace: biological_process
id: GO:0016458
in_subset: goslim drosophila
in_subset: goslim pir
comment: This is a rather broad grouping term. While it was originally defined for long-term, heritable, epigenetic effects, short term effects on expression mediated by RNA are also frequently referred to as gene silencing, and are grouped under this class.

Axiom
annotated source: gene silencing
annotated property: definition
annotated target: Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression.
database_cross_reference: GOC:dos
database_cross_reference: GOC:dph
database_cross_reference: GOC:jid
database_cross_reference: GOC:tb

cytosolic transport
type: Class
equivalent class: Class
  intersection of: transport
  intersection of: Restriction
    on property: occurs in
    some values from: cytosol
subclass of: intracellular transport
subclass of: Restriction
  on property: occurs in
  some values from: cytosol
definition: The directed movement of substances or organelles within the cytosol.
has_obo_namespace: biological_process
id: GO:0016482

Axiom
annotated source: cytosolic transport
annotated property: definition
annotated target: The directed movement of substances or organelles within the cytosol.
database_cross_reference: GOC:ai

negative regulation of angiogenesis
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: angiogenesis
subclass of: regulation of angiogenesis
subclass of: GO_2000181
subclass of: Restriction
  on property: negatively regulates
  some values from: angiogenesis
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
has_exact_synonym: down regulation of angiogenesis
has_exact_synonym: down-regulation of angiogenesis
has_exact_synonym: downregulation of angiogenesis
has_narrow_synonym: inhibition of angiogenesis
has_obo_namespace: biological_process
id: GO:0016525

Axiom
annotated source: negative regulation of angiogenesis
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
database_cross_reference: GOC:go_curators

transferase activity
type: Class
subclass of: catalytic activity
definition: Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
database_cross_reference: EC:2
database_cross_reference: Reactome:R-HSA-1483089
database_cross_reference: Reactome:R-HSA-1483186
database_cross_reference: Reactome:R-HSA-5668414
database_cross_reference: Reactome:R-HSA-6787403
database_cross_reference: Reactome:R-HSA-8868783
has_obo_namespace: molecular_function
id: GO:0016740
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

Axiom
annotated source: transferase activity
annotated property: definition
annotated target: Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
database_cross_reference: ISBN:0198506732

PE is converted to PS by PTDSS2
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1483089

PC is converted to PS by PTDSS1
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1483186

TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5668414

GTPBP3 and MTO1 transform uridine-34 yielding 5-taurinomethyluridine-34 in tRNA
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6787403

TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8868783

transferase activity, transferring phosphorus-containing groups
type: Class
subclass of: transferase activity
definition: Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).
database_cross_reference: EC:2.7
has_obo_namespace: molecular_function
id: GO:0016772
in_subset: goslim chembl
comment: Note that this term encompasses all kinase activities, as well as activities that transfer other phosphorus-containing groups such as diphosphate or nucleotides.

Axiom
annotated source: transferase activity, transferring phosphorus-containing groups
annotated property: definition
annotated target: Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732

hydrolase activity
type: Class
subclass of: catalytic activity
definition: Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
database_cross_reference: EC:3
database_cross_reference: Reactome:R-HSA-1236938
database_cross_reference: Reactome:R-HSA-2029475
database_cross_reference: Reactome:R-HSA-5694583
database_cross_reference: Reactome:R-HSA-5695964
database_cross_reference: Reactome:R-HSA-6786190
database_cross_reference: Reactome:R-HSA-6788295
database_cross_reference: Reactome:R-HSA-8938314
database_cross_reference: Reactome:R-HSA-8952137
has_obo_namespace: molecular_function
id: GO:0016787
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

Axiom
annotated source: hydrolase activity
annotated property: definition
annotated target: Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
database_cross_reference: ISBN:0198506732

Partial proteolysis of antigen in phagolysosomes
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1236938

Production of AA by iPLA2 upon FCGR activation
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2029475

ABHD4 hydrolyses NAPE
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5694583

ABHD14B hydrolyses PNPB
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5695964

CMBL hydrolyses OM to OLMS
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6786190

HDHD1:Mg2+ dephosphorylates PURIDP
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6788295

ENPPs hydrolyse CoA-SH to PPANT, PAP
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8938314

Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8952137

ligase activity
type: Class
subclass of: catalytic activity
definition: Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
database_cross_reference: EC:6
has_exact_synonym: synthetase activity
has_obo_namespace: molecular_function
id: GO:0016874
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: ligase activity
annotated property: definition
annotated target: Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
database_cross_reference: EC:6
database_cross_reference: GOC:mah

Axiom
annotated source: ligase activity
annotated property: has_exact_synonym
annotated target: synthetase activity
database_cross_reference: GOC:jh2

ligase activity, forming carbon-sulfur bonds
type: Class
subclass of: ligase activity
definition: Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
database_cross_reference: EC:6.2
has_exact_synonym: ligase activity, forming carbon-sulphur bonds
has_obo_namespace: molecular_function
id: GO:0016877

Axiom
annotated source: ligase activity, forming carbon-sulfur bonds
annotated property: definition
annotated target: Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
database_cross_reference: EC:6.2
database_cross_reference: GOC:mah

ligase activity, forming carbon-nitrogen bonds
type: Class
subclass of: ligase activity
definition: Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
database_cross_reference: EC:6.3
has_narrow_synonym: other carbon-nitrogen ligase activity
has_obo_namespace: molecular_function
id: GO:0016879

Axiom
annotated source: ligase activity, forming carbon-nitrogen bonds
annotated property: definition
annotated target: Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
database_cross_reference: GOC:mah

acid-amino acid ligase activity
type: Class
subclass of: ligase activity, forming carbon-nitrogen bonds
definition: Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
database_cross_reference: EC:6.3.2
has_exact_synonym: peptide synthase activity
has_obo_namespace: molecular_function
id: GO:0016881

Axiom
annotated source: acid-amino acid ligase activity
annotated property: definition
annotated target: Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

nuclear receptor binding
type: Class
subclass of: nuclear hormone receptor binding
definition: Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein.
has_exact_synonym: ligand-dependent nuclear receptor binding
has_obo_namespace: molecular_function
has_related_synonym: ligand-dependent nuclear receptor interactor activity
id: GO:0016922

Axiom
annotated source: nuclear receptor binding
annotated property: definition
annotated target: Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein.
database_cross_reference: GOC:mah
database_cross_reference: PMID:7776974

drug metabolic process
type: Class
subclass of: cellular metabolic process
definition: The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice.
database_cross_reference: Wikipedia:Drug_metabolism
has_exact_synonym: drug metabolism
has_obo_namespace: biological_process
id: GO:0017144
in_subset: goslim chembl
in_subset: goslim pir

Axiom
annotated source: drug metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice.
database_cross_reference: GOC:cab2

stem cell division
type: Class
subclass of: GO_0051301
definition: The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types.
has_exact_synonym: stem cell renewal
has_obo_namespace: biological_process
id: GO:0017145

Axiom
annotated source: stem cell division
annotated property: definition
annotated target: The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types.
database_cross_reference: GOC:jid
database_cross_reference: ISBN:0582227089

heterocycle biosynthetic process
type: Class
subclass of: cellular biosynthetic process
subclass of: heterocycle metabolic process
definition: The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
has_exact_synonym: heterocycle anabolism
has_exact_synonym: heterocycle biosynthesis
has_exact_synonym: heterocycle formation
has_exact_synonym: heterocycle synthesis
has_obo_namespace: biological_process
id: GO:0018130

Axiom
annotated source: heterocycle biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
database_cross_reference: ISBN:0198547684

host cellular component
type: Class
subclass of: GO_0110165
definition: Any organism in which another organism, especially a parasite or symbiont, spends part or all of its life cycle and from which it obtains nourishment and/or protection.
database_cross_reference: Wikipedia:Host_(biology)
has_exact_synonym: host organism
has_obo_namespace: cellular_component
id: GO:0018995

Axiom
annotated source: host cellular component
annotated property: definition
annotated target: Any organism in which another organism, especially a parasite or symbiont, spends part or all of its life cycle and from which it obtains nourishment and/or protection.
database_cross_reference: ISBN:0198506732

reproductive behavior
type: Class
equivalent class: Class
  intersection of: behavior
  intersection of: Restriction
    on property: part of
    some values from: reproduction
subclass of: behavior
subclass of: multicellular organismal reproductive process
definition: The specific behavior of an organism that is associated with reproduction.
created by: janelomax
creation date: 2012-09-19T16:01:37Z
has_alternative_id: GO:0033057
has_alternative_id: GO:0044704
has_exact_synonym: reproductive behavior in a multicellular organism
has_exact_synonym: reproductive behaviour
has_narrow_synonym: multicellular organism reproductive behavior
has_obo_namespace: biological_process
has_related_synonym: single-organism reproductive behavior
id: GO:0019098
in_subset: goslim drosophila

Axiom
annotated source: reproductive behavior
annotated property: definition
annotated target: The specific behavior of an organism that is associated with reproduction.
database_cross_reference: GOC:jl
database_cross_reference: GOC:pr

regulation of lipid metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: lipid metabolic process
subclass of: GO_0080090
subclass of: Restriction
  on property: regulates
  some values from: lipid metabolic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
has_exact_synonym: regulation of lipid metabolism
has_obo_namespace: biological_process
id: GO:0019216

Axiom
annotated source: regulation of lipid metabolic process
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
database_cross_reference: GOC:go_curators

regulation of nucleobase-containing compound metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: nucleobase-containing compound metabolic process
subclass of: regulation of cellular metabolic process
subclass of: GO_0051171
subclass of: GO_0080090
subclass of: Restriction
  on property: regulates
  some values from: nucleobase-containing compound metabolic process
definition: Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
has_exact_synonym: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
has_obo_namespace: biological_process
has_related_synonym: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
id: GO:0019219

Axiom
annotated source: regulation of nucleobase-containing compound metabolic process
annotated property: definition
annotated target: Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
database_cross_reference: GOC:go_curators

Axiom
annotated source: regulation of nucleobase-containing compound metabolic process
annotated property: has_related_synonym
annotated target: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

regulation of phosphate metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: phosphate-containing compound metabolic process
subclass of: GO_0051174
subclass of: Restriction
  on property: regulates
  some values from: phosphate-containing compound metabolic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates.
has_exact_synonym: regulation of phosphate metabolism
has_obo_namespace: biological_process
id: GO:0019220

Axiom
annotated source: regulation of phosphate metabolic process
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates.
database_cross_reference: GOC:go_curators

regulation of metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: metabolic process
subclass of: GO_0050789
subclass of: Restriction
  on property: regulates
  some values from: metabolic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
has_alternative_id: GO:0044246
has_exact_synonym: regulation of metabolism
has_narrow_synonym: regulation of multicellular organismal metabolic process
has_narrow_synonym: regulation of organismal metabolic process
has_obo_namespace: biological_process
id: GO:0019222
in_subset: goslim metagenomics

Axiom
annotated source: regulation of metabolic process
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
database_cross_reference: GOC:go_curators

Axiom
annotated source: regulation of metabolic process
annotated property: has_narrow_synonym
annotated target: regulation of organismal metabolic process
database_cross_reference: GOC:tb

sensory perception of pain
type: Class
subclass of: sensory perception
definition: The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.
database_cross_reference: Wikipedia:Nociception
has_exact_synonym: nociception
has_narrow_synonym: perception of physiological pain
has_obo_namespace: biological_process
id: GO:0019233

Axiom
annotated source: sensory perception of pain
annotated property: definition
annotated target: The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.
database_cross_reference: GOC:curators

aromatic compound biosynthetic process
type: Class
subclass of: cellular aromatic compound metabolic process
subclass of: cellular biosynthetic process
definition: The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring.
has_exact_synonym: aromatic compound anabolism
has_exact_synonym: aromatic compound biosynthesis
has_exact_synonym: aromatic compound formation
has_exact_synonym: aromatic compound synthesis
has_narrow_synonym: aromatic hydrocarbon biosynthesis
has_narrow_synonym: aromatic hydrocarbon biosynthetic process
has_obo_namespace: biological_process
id: GO:0019438

Axiom
annotated source: aromatic compound biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring.
database_cross_reference: GOC:ai

protein metabolic process
type: Class
subclass of: macromolecule metabolic process
subclass of: primary metabolic process
subclass of: GO_1901564
definition: The chemical reactions and pathways involving a protein. Includes protein modification.
has_alternative_id: GO:0006411
has_alternative_id: GO:0044268
database_cross_reference: Wikipedia:Protein_metabolism
has_exact_synonym: protein metabolic process and modification
has_exact_synonym: protein metabolism
has_exact_synonym: protein metabolism and modification
has_narrow_synonym: multicellular organismal protein metabolic process
has_obo_namespace: biological_process
id: GO:0019538
in_subset: goslim agr
in_subset: goslim flybase ribbon
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant

Axiom
annotated source: protein metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving a protein. Includes protein modification.
database_cross_reference: GOC:ma

organophosphate metabolic process
type: Class
subclass of: phosphorus metabolic process
subclass of: GO_0071704
definition: The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound.
has_exact_synonym: organophosphate metabolism
has_obo_namespace: biological_process
id: GO:0019637

Axiom
annotated source: organophosphate metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound.
database_cross_reference: ISBN:0198506732

ribose phosphate metabolic process
type: Class
subclass of: phosphate-containing compound metabolic process
subclass of: organophosphate metabolic process
subclass of: GO_1901135
definition: The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar.
has_exact_synonym: ribose phosphate metabolism
has_obo_namespace: biological_process
id: GO:0019693

Axiom
annotated source: ribose phosphate metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar.
database_cross_reference: GOC:ai

B cell mediated immunity
type: Class
subclass of: lymphocyte mediated immunity
subclass of: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
definition: Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.
has_exact_synonym: B lymphocyte mediated immune effector process
has_exact_synonym: B lymphocyte mediated immunity
has_exact_synonym: B-cell mediated immune effector process
has_exact_synonym: B-cell mediated immunity
has_exact_synonym: B-lymphocyte mediated immune effector process
has_exact_synonym: B-lymphocyte mediated immunity
has_obo_namespace: biological_process
id: GO:0019724

Axiom
annotated source: B cell mediated immunity
annotated property: definition
annotated target: Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.
database_cross_reference: GOC:add
database_cross_reference: GO_REF:0000022
database_cross_reference: ISBN:0781735149

cellular homeostasis
type: Class
subclass of: cellular process
subclass of: homeostatic process
definition: Any process involved in the maintenance of an internal steady state at the level of the cell.
has_obo_namespace: biological_process
id: GO:0019725
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim plant

Axiom
annotated source: cellular homeostasis
annotated property: definition
annotated target: Any process involved in the maintenance of an internal steady state at the level of the cell.
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0395825172

regulation of isoprenoid metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: isoprenoid metabolic process
subclass of: regulation of lipid metabolic process
subclass of: regulation of cellular metabolic process
subclass of: Restriction
  on property: regulates
  some values from: isoprenoid metabolic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving isoprenoids.
has_exact_synonym: regulation of isoprenoid metabolism
has_obo_namespace: biological_process
id: GO:0019747

Axiom
annotated source: regulation of isoprenoid metabolic process
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving isoprenoids.
database_cross_reference: GOC:go_curators

carboxylic acid metabolic process
type: Class
subclass of: oxoacid metabolic process
definition: The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
has_exact_synonym: carboxylic acid metabolism
has_obo_namespace: biological_process
id: GO:0019752

Axiom
annotated source: carboxylic acid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
database_cross_reference: ISBN:0198506732

Atg12 transferase activity
type: Class
subclass of: small conjugating protein ligase activity
definition: Catalysis of the transfer of ATG12 from one protein to another via the reaction X-ATG12 + Y --> Y-ATG12 + X, where both X-ATG12 and Y-ATG12 are covalent linkages.
database_cross_reference: Reactome:R-HSA-5681999
has_narrow_synonym: APG12 conjugating enzyme activity
has_narrow_synonym: APG12 ligase activity
has_narrow_synonym: Atg12 conjugating enzyme activity
has_narrow_synonym: Atg12 ligase activity
has_obo_namespace: molecular_function
id: GO:0019777

Axiom
annotated source: Atg12 transferase activity
annotated property: definition
annotated target: Catalysis of the transfer of ATG12 from one protein to another via the reaction X-ATG12 + Y --> Y-ATG12 + X, where both X-ATG12 and Y-ATG12 are covalent linkages.
database_cross_reference: GOC:mah
database_cross_reference: PMID:12826404

ATG10 transfers ATG12 from ATG7 to ATG10
type: Axiom
annotated source: Atg12 transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5681999

Atg12 activating enzyme activity
type: Class
subclass of: ubiquitin-like modifier activating enzyme activity
definition: Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond.
has_obo_namespace: molecular_function
has_related_synonym: APG12 activating enzyme activity
id: GO:0019778

Axiom
annotated source: Atg12 activating enzyme activity
annotated property: definition
annotated target: Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond.
database_cross_reference: GOC:mah

Axiom
annotated source: Atg12 activating enzyme activity
annotated property: has_related_synonym
annotated target: APG12 activating enzyme activity
database_cross_reference: GOC:vw

ubiquitin-like protein-specific protease activity
type: Class
subclass of: cysteine-type peptidase activity
definition: Catalysis of the hydrolysis of peptide or isopeptide bonds within small proteins such as ubiquitin or ubiquitin-like proteins (e.g. APG8, ISG15, NEDD8, SUMO), or between the small protein and a larger protein to which it has been conjugated.
has_alternative_id: GO:1904454
has_alternative_id: GO:1904455
has_exact_synonym: small conjugating protein-specific protease activity
has_narrow_synonym: ubiquitin-like specific protease activity
has_narrow_synonym: ubiquitin-like-protein-specific protease activity
has_narrow_synonym: ubiquitin-specific protease activity involved in negative regulation of ERAD pathway
has_narrow_synonym: ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
has_obo_namespace: molecular_function
id: GO:0019783

Axiom
annotated source: ubiquitin-like protein-specific protease activity
annotated property: definition
annotated target: Catalysis of the hydrolysis of peptide or isopeptide bonds within small proteins such as ubiquitin or ubiquitin-like proteins (e.g. APG8, ISG15, NEDD8, SUMO), or between the small protein and a larger protein to which it has been conjugated.
database_cross_reference: GOC:ma
database_cross_reference: GOC:mah

Axiom
annotated source: ubiquitin-like protein-specific protease activity
annotated property: has_exact_synonym
annotated target: small conjugating protein-specific protease activity
database_cross_reference: GOC:dph

Atg8-specific protease activity
type: Class
subclass of: ubiquitin-like protein-specific protease activity
definition: Catalysis of the hydrolysis of APG8, a small ubiquitin-related modifier.
has_obo_namespace: molecular_function
has_related_synonym: APG8-PE hydrolase
has_related_synonym: APG8-specific protease activity
id: GO:0019786

Axiom
annotated source: Atg8-specific protease activity
annotated property: definition
annotated target: Catalysis of the hydrolysis of APG8, a small ubiquitin-related modifier.
database_cross_reference: GOC:mah

Axiom
annotated source: Atg8-specific protease activity
annotated property: has_related_synonym
annotated target: APG8-specific protease activity
database_cross_reference: GOC:vw

small conjugating protein ligase activity
type: Class
subclass of: transferase activity
subclass of: acid-amino acid ligase activity
subclass of: GO_0140096
definition: Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y --> Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein.
has_alternative_id: GO:0008639
has_alternative_id: GO:0008640
database_cross_reference: Reactome:R-HSA-5678490
database_cross_reference: Reactome:R-HSA-688137
has_exact_synonym: small conjugating protein transferase activity
has_narrow_synonym: small conjugating protein ligase activity
has_narrow_synonym: small protein conjugating enzyme activity
has_narrow_synonym: ubiquitin-like conjugating enzyme activity
has_narrow_synonym: ubiquitin-like-protein ligase activity
has_obo_namespace: molecular_function
has_related_synonym: E2
has_related_synonym: E3
id: GO:0019787
in_subset: goslim drosophila
in_subset: goslim pir
label: ubiquitin-like protein transferase activity

Axiom
annotated source: small conjugating protein ligase activity
annotated property: definition
annotated target: Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y --> Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein.
database_cross_reference: GOC:mah
database_cross_reference: GOC:rn
database_cross_reference: PMID:10806345
database_cross_reference: PMID:10884686

ATG16L1 complex transfers LC3 from ATG3 to PE
type: Axiom
annotated source: small conjugating protein ligase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5678490

RIP2 is K63 polyubiquitinated
type: Axiom
annotated source: small conjugating protein ligase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-688137

Axiom
annotated source: small conjugating protein ligase activity
annotated property: has_exact_synonym
annotated target: small conjugating protein transferase activity
database_cross_reference: GOC:dph

Axiom
annotated source: small conjugating protein ligase activity
annotated property: has_narrow_synonym
annotated target: small conjugating protein ligase activity
database_cross_reference: GOC:dph

Axiom
annotated source: small conjugating protein ligase activity
annotated property: has_related_synonym
annotated target: E3
database_cross_reference: dph:GOC

outer membrane
type: Class
subclass of: membrane
definition: The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
has_obo_namespace: cellular_component
id: GO:0019867
in_subset: goslim metagenomics

Axiom
annotated source: outer membrane
annotated property: definition
annotated target: The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
database_cross_reference: GOC:go_curators

sexual reproduction
type: Class
subclass of: reproduction
subclass of: multi-organism reproductive process
definition: A reproduction process that creates a new organism by combining the genetic material of two gametes, which may come from two organisms or from a single organism, in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two gametes join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny.
database_cross_reference: Wikipedia:Sexual_reproduction
has_obo_namespace: biological_process
id: GO:0019953
comment: Sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times.

Axiom
annotated source: sexual reproduction
annotated property: definition
annotated target: A reproduction process that creates a new organism by combining the genetic material of two gametes, which may come from two organisms or from a single organism, in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two gametes join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny.
database_cross_reference: GOC:jl
database_cross_reference: GOC:kmv
database_cross_reference: GOC:krc
database_cross_reference: GOC:tb
database_cross_reference: ISBN:0387520546
database_cross_reference: Wikipedia:Sexual_reproduction

asexual reproduction
type: Class
subclass of: reproduction
definition: The biological process in which new individuals are produced by either a single cell or a group of cells, in the absence of any sexual process.
database_cross_reference: Wikipedia:Asexual_reproduction
has_obo_namespace: biological_process
has_related_synonym: parthenogenesis
id: GO:0019954

Axiom
annotated source: asexual reproduction
annotated property: definition
annotated target: The biological process in which new individuals are produced by either a single cell or a group of cells, in the absence of any sexual process.
database_cross_reference: ISBN:0387520546

Axiom
annotated source: asexual reproduction
annotated property: has_related_synonym
annotated target: parthenogenesis
database_cross_reference: Wikipedia:Parthenogenesis

developmental maturation
type: Class
subclass of: developmental process
definition: A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state.
has_obo_namespace: biological_process
id: GO:0021700
in_subset: goslim chembl
in_subset: goslim generic

Axiom
annotated source: developmental maturation
annotated property: definition
annotated target: A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state.
database_cross_reference: GOC:cls
database_cross_reference: GOC:dgh
database_cross_reference: GOC:dph
database_cross_reference: GOC:jid
database_cross_reference: GO_REF:0000021

neurogenesis
type: Class
subclass of: cell differentiation
subclass of: Restriction
  on property: part of
  some values from: nervous system development
definition: Generation of cells within the nervous system.
database_cross_reference: Wikipedia:Neurogenesis
has_exact_synonym: nervous system cell generation
has_obo_namespace: biological_process
has_related_synonym: neural cell differentiation
id: GO:0022008

Axiom
annotated source: neurogenesis
annotated property: definition
annotated target: Generation of cells within the nervous system.
database_cross_reference: GOC:cls
database_cross_reference: GOC:curators
database_cross_reference: GOC:dgh
database_cross_reference: GOC:dph
database_cross_reference: GOC:jid
database_cross_reference: GO_REF:0000021

Axiom
annotated source: neurogenesis
annotated property: has_exact_synonym
annotated target: nervous system cell generation
has_synonym_type: Systematic synonym

Axiom
annotated source: neurogenesis
annotated property: has_related_synonym
annotated target: neural cell differentiation
database_cross_reference: GOC:BHF
database_cross_reference: GOC:dph

regulation of rhodopsin mediated signaling pathway
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: rhodopsin mediated signaling pathway
subclass of: regulation of G protein-coupled receptor signaling pathway
subclass of: regulation of response to external stimulus
subclass of: Restriction
  on property: regulates
  some values from: rhodopsin mediated signaling pathway
definition: Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling.
has_exact_synonym: regulation of rhodopsin mediated signalling
has_obo_namespace: biological_process
id: GO:0022400

Axiom
annotated source: regulation of rhodopsin mediated signaling pathway
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling.
database_cross_reference: GOC:mah

cell cycle process
type: Class
equivalent class: Class
  intersection of: cellular process
  intersection of: Restriction
    on property: part of
    some values from: cell cycle
subclass of: cellular process
subclass of: Restriction
  on property: part of
  some values from: cell cycle
definition: The cellular process that ensures successive accurate and complete genome replication and chromosome segregation.
has_obo_namespace: biological_process
id: GO:0022402
in_subset: gocheck do not annotate

Axiom
annotated source: cell cycle process
annotated property: definition
annotated target: The cellular process that ensures successive accurate and complete genome replication and chromosome segregation.
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:mtg_cell_cycle

cell cycle phase
type: Class
subclass of: biological phase
definition: One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.
has_obo_namespace: biological_process
id: GO:0022403
in_subset: gocheck do not annotate

Axiom
annotated source: cell cycle phase
annotated property: definition
annotated target: One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.
database_cross_reference: GOC:mtg_cell_cycle

membrane docking
type: Class
subclass of: cellular process
definition: The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere.
has_exact_synonym: membrane docking
has_obo_namespace: biological_process
id: GO:0022406
in_subset: goslim pir

Axiom
annotated source: membrane docking
annotated property: definition
annotated target: The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere.
database_cross_reference: GOC:isa_complete
database_cross_reference: PMID:27875684

regulation of cell-cell adhesion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: GO_0098609
subclass of: regulation of cell adhesion
subclass of: Restriction
  on property: regulates
  some values from: GO_0098609
definition: Any process that modulates the frequency, rate or extent of attachment of a cell to another cell.
has_obo_namespace: biological_process
id: GO:0022407

Axiom
annotated source: regulation of cell-cell adhesion
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of attachment of a cell to another cell.
database_cross_reference: GOC:isa_complete

negative regulation of cell-cell adhesion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: GO_0098609
subclass of: negative regulation of cell adhesion
subclass of: regulation of cell-cell adhesion
subclass of: Restriction
  on property: negatively regulates
  some values from: GO_0098609
definition: Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell.
has_exact_synonym: down regulation of cell-cell adhesion
has_exact_synonym: down-regulation of cell-cell adhesion
has_exact_synonym: downregulation of cell-cell adhesion
has_narrow_synonym: inhibition of cell-cell adhesion
has_obo_namespace: biological_process
id: GO:0022408

Axiom
annotated source: negative regulation of cell-cell adhesion
annotated property: definition
annotated target: Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell.
database_cross_reference: GOC:isa_complete

positive regulation of cell-cell adhesion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: GO_0098609
subclass of: regulation of cell-cell adhesion
subclass of: positive regulation of cell adhesion
subclass of: Restriction
  on property: positively regulates
  some values from: GO_0098609
definition: Any process that activates or increases the rate or extent of cell adhesion to another cell.
has_exact_synonym: up regulation of cell-cell adhesion
has_exact_synonym: up-regulation of cell-cell adhesion
has_exact_synonym: upregulation of cell-cell adhesion
has_narrow_synonym: activation of cell-cell adhesion
has_narrow_synonym: stimulation of cell-cell adhesion
has_obo_namespace: biological_process
id: GO:0022409

Axiom
annotated source: positive regulation of cell-cell adhesion
annotated property: definition
annotated target: Any process that activates or increases the rate or extent of cell adhesion to another cell.
database_cross_reference: GOC:isa_complete

circadian sleep/wake cycle process
type: Class
subclass of: circadian behavior
subclass of: Restriction
  on property: part of
  some values from: circadian sleep/wake cycle
definition: A behavioral process involved in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm.
has_obo_namespace: biological_process
id: GO:0022410

Axiom
annotated source: circadian sleep/wake cycle process
annotated property: definition
annotated target: A behavioral process involved in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm.
database_cross_reference: GOC:isa_complete

cellular component disassembly
type: Class
subclass of: cellular component organization
definition: A cellular process that results in the breakdown of a cellular component.
has_alternative_id: GO:0071845
has_exact_synonym: cell structure disassembly
has_exact_synonym: cellular component disassembly at cellular level
has_obo_namespace: biological_process
id: GO:0022411
in_subset: goslim pir

Axiom
annotated source: cellular component disassembly
annotated property: definition
annotated target: A cellular process that results in the breakdown of a cellular component.
database_cross_reference: GOC:isa_complete

cellular process involved in reproduction in multicellular organism
type: Class
equivalent class: Class
  intersection of: cellular process
  intersection of: Restriction
    on property: part of
    some values from: multicellular organism reproduction
subclass of: cellular process
subclass of: reproductive process
subclass of: Restriction
  on property: part of
  some values from: multicellular organism reproduction
definition: A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism.
has_exact_synonym: reproductive cellular process in multicellular organism
has_obo_namespace: biological_process
id: GO:0022412

Axiom
annotated source: cellular process involved in reproduction in multicellular organism
annotated property: definition
annotated target: A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism.
database_cross_reference: GOC:isa_complete

reproductive process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: part of
    some values from: reproduction
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: reproduction
disjoint with: biological phase
definition: A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.
created by: janelomax
creation date: 2012-09-19T15:56:06Z
has_alternative_id: GO:0044702
has_obo_namespace: biological_process
has_related_synonym: single organism reproductive process
id: GO:0022414

Axiom
annotated source: reproductive process
annotated property: definition
annotated target: A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.
database_cross_reference: GOC:dph
database_cross_reference: GOC:isa_complete

regulation of anatomical structure morphogenesis
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: anatomical structure morphogenesis
subclass of: GO_0050793
subclass of: Restriction
  on property: regulates
  some values from: anatomical structure morphogenesis
definition: Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis.
has_exact_synonym: regulation of morphogenesis
has_obo_namespace: biological_process
id: GO:0022603

Axiom
annotated source: regulation of anatomical structure morphogenesis
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis.
database_cross_reference: GOC:mah

cellular component assembly
type: Class
subclass of: cellular component organization
subclass of: Restriction
  on property: part of
  some values from: cellular component biogenesis
definition: The aggregation, arrangement and bonding together of a cellular component.
has_alternative_id: GO:0071844
has_exact_synonym: cell structure assembly
has_exact_synonym: cellular component assembly at cellular level
has_obo_namespace: biological_process
id: GO:0022607
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim pir

Axiom
annotated source: cellular component assembly
annotated property: definition
annotated target: The aggregation, arrangement and bonding together of a cellular component.
database_cross_reference: GOC:isa_complete

biological adhesion
type: Class
subclass of: biological_process
disjoint with: biological phase
definition: The attachment of a cell or organism to a substrate, another cell, or other organism. Biological adhesion includes intracellular attachment between membrane regions.
has_obo_namespace: biological_process
id: GO:0022610
in_subset: goslim pir

Axiom
annotated source: biological adhesion
annotated property: definition
annotated target: The attachment of a cell or organism to a substrate, another cell, or other organism. Biological adhesion includes intracellular attachment between membrane regions.
database_cross_reference: GOC:isa_complete

transmembrane transporter activity
type: Class
subclass of: transporter activity
subclass of: Restriction
  on property: part of
  some values from: GO_0055085
definition: Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
has_alternative_id: GO:0005386
has_alternative_id: GO:0015563
has_alternative_id: GO:0015646
has_alternative_id: GO:0022891
has_alternative_id: GO:0022892
database_cross_reference: Reactome:R-HSA-1236947
database_cross_reference: Reactome:R-HSA-429036
database_cross_reference: Reactome:R-HSA-5638209
database_cross_reference: Reactome:R-HSA-5671707
database_cross_reference: Reactome:R-HSA-6784434
database_cross_reference: Reactome:R-HSA-6784436
has_obo_namespace: molecular_function
has_related_synonym: substrate-specific transmembrane transporter activity
has_related_synonym: substrate-specific transporter activity
has_related_synonym: uptake permease activity
has_related_synonym: uptake transmembrane transporter activity
id: GO:0022857
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim yeast

Axiom
annotated source: transmembrane transporter activity
annotated property: definition
annotated target: Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
database_cross_reference: GOC:jid
database_cross_reference: GOC:mtg_transport
database_cross_reference: ISBN:0815340729

Egress of internalized antigen to the cytosol via sec61
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1236947

SLC2A9 transports Fru, Glc, urate
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-429036

Defective SLC2A9 does not transport Fru, Glc, urate
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5638209

Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5671707

An unknown carrier transports cytosolic glyoxylate to the peroxisome
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6784434

An unknown carrier transports mitochondrial glyoxylate to the cytosol
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6784436

regulation of transmembrane transporter activity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: transmembrane transporter activity
subclass of: regulation of transporter activity
subclass of: regulation of transmembrane transport
subclass of: Restriction
  on property: regulates
  some values from: transmembrane transporter activity
definition: Any process that modulates the frequency, rate or extent of transmembrane transporter activity.
has_obo_namespace: biological_process
id: GO:0022898

Axiom
annotated source: regulation of transmembrane transporter activity
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of transmembrane transporter activity.
database_cross_reference: GOC:dph
database_cross_reference: GOC:mtg_cardio
database_cross_reference: GOC:mtg_transport

signal transduction by protein phosphorylation
type: Class
subclass of: protein phosphorylation
subclass of: signal transduction
definition: A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate.
creation date: 2010-02-16T09:30:50Z
has_obo_namespace: biological_process
has_related_synonym: signal transduction via phosphorylation event
has_related_synonym: signal transmission via phosphorylation event
id: GO:0023014

Axiom
annotated source: signal transduction by protein phosphorylation
annotated property: definition
annotated target: A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate.
database_cross_reference: GOC:mtg_signal
database_cross_reference: GOC:signaling

Axiom
annotated source: signal transduction by protein phosphorylation
annotated property: has_related_synonym
annotated target: signal transduction via phosphorylation event
database_cross_reference: GOC:bf

Axiom
annotated source: signal transduction by protein phosphorylation
annotated property: has_related_synonym
annotated target: signal transmission via phosphorylation event
database_cross_reference: GOC:bf

signal transduction involved in regulation of gene expression
type: Class
equivalent class: Class
  intersection of: signal transduction
  intersection of: Restriction
    on property: part of
    some values from: regulation of gene expression
subclass of: signal transduction
subclass of: Restriction
  on property: part of
  some values from: regulation of gene expression
definition: Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another.
creation date: 2010-02-16T09:30:50Z
has_obo_namespace: biological_process
has_related_synonym: regulation of gene expression as a consequence of signal transmission
id: GO:0023019

Axiom
annotated source: signal transduction involved in regulation of gene expression
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another.
database_cross_reference: GOC:mtg_signal

Axiom
annotated source: signal transduction involved in regulation of gene expression
annotated property: has_related_synonym
annotated target: regulation of gene expression as a consequence of signal transmission
database_cross_reference: GOC:bf

regulation of signaling
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: signaling
subclass of: GO_0050789
subclass of: Restriction
  on property: regulates
  some values from: signaling
definition: Any process that modulates the frequency, rate or extent of a signaling process.
creation date: 2010-02-16T09:30:50Z
has_obo_namespace: biological_process
has_related_synonym: regulation of signaling process
has_related_synonym: regulation of signalling process
id: GO:0023051

Axiom
annotated source: regulation of signaling
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of a signaling process.
database_cross_reference: GOC:mtg_signal

Axiom
annotated source: regulation of signaling
annotated property: has_related_synonym
annotated target: regulation of signaling process
database_cross_reference: GOC:bf

Axiom
annotated source: regulation of signaling
annotated property: has_related_synonym
annotated target: regulation of signalling process
database_cross_reference: GOC:mah

signaling
type: Class
subclass of: biological_process
disjoint with: biological phase
definition: The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
created by: janelomax
creation date: 2010-02-16T09:30:50Z
has_alternative_id: GO:0023046
has_alternative_id: GO:0044700
has_exact_synonym: biological signaling
has_exact_synonym: signaling process
has_exact_synonym: signalling
has_obo_namespace: biological_process
has_related_synonym: signalling process
has_related_synonym: single organism signaling
id: GO:0023052
in_subset: goslim agr
in_subset: goslim flybase ribbon
in_subset: goslim mouse
in_subset: goslim pombe
in_subset: goslim yeast
comment: Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change.

Axiom
annotated source: signaling
annotated property: definition
annotated target: The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
database_cross_reference: GOC:mtg_signal
database_cross_reference: GOC:mtg_signaling_feb11
database_cross_reference: GOC:signaling

Axiom
annotated source: signaling
annotated property: has_related_synonym
annotated target: signalling process
database_cross_reference: GOC:mah

positive regulation of signaling
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: signaling
subclass of: regulation of signaling
subclass of: positive regulation of biological process
subclass of: Restriction
  on property: positively regulates
  some values from: signaling
definition: Any process that activates, maintains or increases the frequency, rate or extent of a signaling process.
creation date: 2010-02-16T09:30:50Z
has_exact_synonym: positive regulation of signalling process
has_obo_namespace: biological_process
has_related_synonym: positive regulation of signaling process
id: GO:0023056

Axiom
annotated source: positive regulation of signaling
annotated property: definition
annotated target: Any process that activates, maintains or increases the frequency, rate or extent of a signaling process.
database_cross_reference: GOC:mtg_signal

Axiom
annotated source: positive regulation of signaling
annotated property: has_exact_synonym
annotated target: positive regulation of signalling process
database_cross_reference: GOC:mah

Axiom
annotated source: positive regulation of signaling
annotated property: has_related_synonym
annotated target: positive regulation of signaling process
database_cross_reference: GOC:bf

negative regulation of signaling
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: signaling
subclass of: regulation of signaling
subclass of: negative regulation of biological process
subclass of: Restriction
  on property: negatively regulates
  some values from: signaling
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process.
creation date: 2010-02-16T09:30:50Z
has_obo_namespace: biological_process
has_related_synonym: negative regulation of signaling process
has_related_synonym: negative regulation of signalling process
id: GO:0023057

Axiom
annotated source: negative regulation of signaling
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process.
database_cross_reference: GOC:mtg_signal

Axiom
annotated source: negative regulation of signaling
annotated property: has_related_synonym
annotated target: negative regulation of signaling process
database_cross_reference: GOC:bf

Axiom
annotated source: negative regulation of signaling
annotated property: has_related_synonym
annotated target: negative regulation of signalling process
database_cross_reference: GOC:mah

signal release
type: Class
equivalent class: Class
  intersection of: secretion by cell
  intersection of: Restriction
    on property: part of
    some values from: cell-cell signaling
subclass of: secretion by cell
subclass of: Restriction
  on property: part of
  some values from: cell-cell signaling
definition: The process in which a signal is secreted or discharged into the extracellular medium from a cellular source.
creation date: 2010-02-16T09:30:50Z
has_exact_synonym: signal secretion
has_obo_namespace: biological_process
id: GO:0023061

Axiom
annotated source: signal release
annotated property: definition
annotated target: The process in which a signal is secreted or discharged into the extracellular medium from a cellular source.
database_cross_reference: GOC:mtg_signal

Axiom
annotated source: signal release
annotated property: has_exact_synonym
annotated target: signal secretion
database_cross_reference: GOC:bf

cellular cation homeostasis
type: Class
subclass of: cellular ion homeostasis
subclass of: GO_0055080
definition: Any process involved in the maintenance of an internal steady state of cations at the level of a cell.
has_obo_namespace: biological_process
id: GO:0030003

Axiom
annotated source: cellular cation homeostasis
annotated property: definition
annotated target: Any process involved in the maintenance of an internal steady state of cations at the level of a cell.
database_cross_reference: GOC:ceb
database_cross_reference: GOC:mah

cell projection organization
type: Class
subclass of: cellular component organization
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
has_exact_synonym: cell projection organisation
has_obo_namespace: biological_process
has_related_synonym: cell projection organization and biogenesis
has_related_synonym: cell surface structure organization and biogenesis
id: GO:0030030

Axiom
annotated source: cell projection organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah
database_cross_reference: http://www.cogsci.princeton.edu/~wn/

Axiom
annotated source: cell projection organization
annotated property: has_related_synonym
annotated target: cell projection organization and biogenesis
database_cross_reference: GOC:mah

Axiom
annotated source: cell projection organization
annotated property: has_related_synonym
annotated target: cell surface structure organization and biogenesis
database_cross_reference: GOC:mah

cell projection assembly
type: Class
subclass of: cellular component assembly
subclass of: cell projection organization
definition: Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon.
has_exact_synonym: formation of a cell surface projection
has_obo_namespace: biological_process
has_related_synonym: cell projection biogenesis
id: GO:0030031

Axiom
annotated source: cell projection assembly
annotated property: definition
annotated target: Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah
database_cross_reference: http://www.cogsci.princeton.edu/~wn/

Axiom
annotated source: cell projection assembly
annotated property: has_related_synonym
annotated target: cell projection biogenesis
database_cross_reference: GOC:mah

cell junction
type: Class
subclass of: GO_0110165
definition: A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.
never in taxon: NCBITaxon 4751
database_cross_reference: Wikipedia:Cell_junction
has_obo_namespace: cellular_component
id: GO:0030054
in_subset: goslim agr
in_subset: goslim drosophila
in_subset: goslim flybase ribbon

Axiom
annotated source: cell junction
annotated property: definition
annotated target: A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.
database_cross_reference: GOC:aruk
database_cross_reference: GOC:bc
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0198506732
database_cross_reference: PMID:26820516
database_cross_reference: PMID:28096264
database_cross_reference: http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html

bacterial thylakoid
type: Class
subclass of: thylakoid
subclass of: intracellular non-membrane-bounded organelle
definition: A thylakoid that is derived from and attached to, but not necessarily continuous with, the plasma membrane, and is not enclosed in a plastid. It bears the photosynthetic pigments in photosynthetic cyanobacteria.
has_exact_synonym: plasma membrane-derived thylakoid
has_obo_namespace: cellular_component
id: GO:0030075

Axiom
annotated source: bacterial thylakoid
annotated property: definition
annotated target: A thylakoid that is derived from and attached to, but not necessarily continuous with, the plasma membrane, and is not enclosed in a plastid. It bears the photosynthetic pigments in photosynthetic cyanobacteria.
database_cross_reference: GOC:mah
database_cross_reference: GOC:mtg_sensu

hemopoiesis
type: Class
subclass of: hematopoietic or lymphoid organ development
definition: The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
database_cross_reference: Wikipedia:Haematopoiesis
has_exact_synonym: blood cell biosynthesis
has_exact_synonym: blood cell formation
has_exact_synonym: haemopoiesis
has_exact_synonym: hematopoiesis
has_obo_namespace: biological_process
id: GO:0030097

Axiom
annotated source: hemopoiesis
annotated property: definition
annotated target: The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
database_cross_reference: GOC:dgh
database_cross_reference: ISBN:0198506732

myeloid cell differentiation
type: Class
subclass of: cell differentiation
subclass of: Restriction
  on property: part of
  some values from: hemopoiesis
definition: The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.
has_obo_namespace: biological_process
id: GO:0030099

Axiom
annotated source: myeloid cell differentiation
annotated property: definition
annotated target: The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.
database_cross_reference: GOC:add
database_cross_reference: ISBN:0781735149

natural killer cell activation
type: Class
subclass of: lymphocyte activation
definition: The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor.
has_exact_synonym: NK cell activation
has_obo_namespace: biological_process
id: GO:0030101

Axiom
annotated source: natural killer cell activation
annotated property: definition
annotated target: The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor.
database_cross_reference: GOC:mgi_curators
database_cross_reference: ISBN:0781735149

transport vesicle
type: Class
subclass of: cytoplasmic vesicle
subclass of: Restriction
  on property: part of
  some values from: endomembrane system
definition: Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.
database_cross_reference: NIF_Subcellular:sao885490876
has_exact_synonym: constitutive secretory pathway transport vesicle
has_narrow_synonym: Golgi to vacuole transport vesicle
has_narrow_synonym: Golgi-vacuole transport vesicle
has_obo_namespace: cellular_component
has_related_synonym: secretory vesicle
id: GO:0030133
comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'secretory granule ; GO:0030141'.

Axiom
annotated source: transport vesicle
annotated property: definition
annotated target: Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.
database_cross_reference: GOC:mah
database_cross_reference: PMID:22160157

COPII-coated ER to Golgi transport vesicle
type: Class
subclass of: Golgi-associated vesicle
subclass of: coated vesicle
definition: A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport).
created by: pg
creation date: 2017-06-22T16:26:57Z
has_alternative_id: GO:0030138
has_alternative_id: GO:0140045
has_exact_synonym: COPII-associated ER to Golgi transport vesicle
has_exact_synonym: COPII-associated vesicle
has_exact_synonym: COPII-coated vesicle
has_obo_namespace: cellular_component
has_related_synonym: COPII vesicle
has_related_synonym: ER to Golgi constitutive secretory pathway transport vesicle
has_related_synonym: ER to Golgi transport vesicle
has_related_synonym: ER-Golgi transport vesicle
has_related_synonym: endoplasmic reticulum to Golgi transport vesicle
has_related_synonym: endoplasmic reticulum-Golgi transport vesicle
id: GO:0030134

Axiom
annotated source: COPII-coated ER to Golgi transport vesicle
annotated property: definition
annotated target: A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport).
database_cross_reference: PMID:11252894
database_cross_reference: PMID:17499046
database_cross_reference: PMID:22160157
database_cross_reference: PMID:8004676
database_cross_reference: Wikipedia:COPII

coated vesicle
type: Class
subclass of: cytoplasmic vesicle
definition: Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins.
has_alternative_id: GO:0005909
database_cross_reference: NIF_Subcellular:sao1985096626
has_obo_namespace: cellular_component
id: GO:0030135
in_subset: goslim drosophila

Axiom
annotated source: coated vesicle
annotated property: definition
annotated target: Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins.
database_cross_reference: ISBN:0815316194

secretory granule
type: Class
subclass of: GO_0099503
subclass of: Restriction
  on property: part of
  some values from: endomembrane system
definition: A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
never in taxon: NCBITaxon 4890
has_broad_synonym: secretory vesicle
has_obo_namespace: cellular_component
id: GO:0030141
comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'transport vesicle ; GO:0030133'.

Axiom
annotated source: secretory granule
annotated property: definition
annotated target: A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0198506732

cell differentiation
type: Class
subclass of: cellular developmental process
definition: The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
database_cross_reference: Wikipedia:Cellular_differentiation
has_obo_namespace: biological_process
id: GO:0030154
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant

Axiom
annotated source: cell differentiation
annotated property: definition
annotated target: The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
database_cross_reference: ISBN:0198506732

regulation of cell adhesion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cell adhesion
subclass of: GO_0050794
subclass of: Restriction
  on property: regulates
  some values from: cell adhesion
definition: Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.
has_obo_namespace: biological_process
has_related_synonym: cell adhesion receptor regulator activity
id: GO:0030155

Axiom
annotated source: regulation of cell adhesion
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.
database_cross_reference: GOC:mah

regulation of proteolysis
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: proteolysis
subclass of: GO_0051246
subclass of: Restriction
  on property: regulates
  some values from: proteolysis
definition: Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
has_exact_synonym: regulation of peptidolysis
has_obo_namespace: biological_process
id: GO:0030162

Axiom
annotated source: regulation of proteolysis
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
database_cross_reference: GOC:mah

platelet activation
type: Class
subclass of: cell activation
subclass of: Restriction
  on property: part of
  some values from: blood coagulation
definition: A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
has_exact_synonym: blood coagulation, platelet activation
has_obo_namespace: biological_process
id: GO:0030168

Axiom
annotated source: platelet activation
annotated property: definition
annotated target: A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
database_cross_reference: http://www.graylab.ac.uk/omd/

Axiom
annotated source: platelet activation
annotated property: has_exact_synonym
annotated target: blood coagulation, platelet activation
database_cross_reference: GOC:add
database_cross_reference: GOC:pde

neuron differentiation
type: Class
subclass of: cell differentiation
subclass of: Restriction
  on property: part of
  some values from: generation of neurons
definition: The process in which a relatively unspecialized cell acquires specialized features of a neuron.
has_obo_namespace: biological_process
id: GO:0030182

Axiom
annotated source: neuron differentiation
annotated property: definition
annotated target: The process in which a relatively unspecialized cell acquires specialized features of a neuron.
database_cross_reference: GOC:mah

regulation of blood coagulation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: blood coagulation
subclass of: regulation of response to external stimulus
subclass of: GO_0050818
subclass of: GO_0061041
subclass of: GO_1900046
subclass of: Restriction
  on property: regulates
  some values from: blood coagulation
definition: Any process that modulates the frequency, rate or extent of blood coagulation.
has_obo_namespace: biological_process
id: GO:0030193

Axiom
annotated source: regulation of blood coagulation
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of blood coagulation.
database_cross_reference: GOC:mah

positive regulation of blood coagulation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: blood coagulation
subclass of: regulation of blood coagulation
subclass of: GO_0050820
subclass of: GO_0090303
subclass of: GO_1900048
subclass of: Restriction
  on property: positively regulates
  some values from: blood coagulation
definition: Any process that activates or increases the frequency, rate or extent of blood coagulation.
has_exact_synonym: up regulation of blood coagulation
has_exact_synonym: up-regulation of blood coagulation
has_exact_synonym: upregulation of blood coagulation
has_narrow_synonym: activation of blood coagulation
has_narrow_synonym: stimulation of blood coagulation
has_obo_namespace: biological_process
id: GO:0030194

Axiom
annotated source: positive regulation of blood coagulation
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of blood coagulation.
database_cross_reference: GOC:mah

negative regulation of blood coagulation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: blood coagulation
subclass of: regulation of blood coagulation
subclass of: GO_0050819
subclass of: GO_0061045
subclass of: GO_1900047
subclass of: Restriction
  on property: negatively regulates
  some values from: blood coagulation
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation.
has_exact_synonym: down regulation of blood coagulation
has_exact_synonym: down-regulation of blood coagulation
has_exact_synonym: downregulation of blood coagulation
has_narrow_synonym: inhibition of blood coagulation
has_obo_namespace: biological_process
id: GO:0030195

Axiom
annotated source: negative regulation of blood coagulation
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation.
database_cross_reference: GOC:mah

extracellular matrix organization
type: Class
subclass of: extracellular structure organization
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
has_exact_synonym: extracellular matrix organisation
has_obo_namespace: biological_process
has_related_synonym: extracellular matrix organization and biogenesis
id: GO:0030198
in_subset: goslim chembl
in_subset: goslim generic

Axiom
annotated source: extracellular matrix organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
database_cross_reference: GOC:mah

Axiom
annotated source: extracellular matrix organization
annotated property: has_related_synonym
annotated target: extracellular matrix organization and biogenesis
database_cross_reference: GOC:mah

erythrocyte differentiation
type: Class
subclass of: myeloid cell differentiation
subclass of: Restriction
  on property: part of
  some values from: erythrocyte homeostasis
definition: The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
database_cross_reference: Wikipedia:Erythropoiesis
has_exact_synonym: RBC differentiation
has_exact_synonym: erythrocyte cell differentiation
has_exact_synonym: erythropoiesis
has_exact_synonym: red blood cell differentiation
has_obo_namespace: biological_process
id: GO:0030218

Axiom
annotated source: erythrocyte differentiation
annotated property: definition
annotated target: The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
database_cross_reference: GOC:mah

Axiom
annotated source: erythrocyte differentiation
annotated property: has_exact_synonym
annotated target: RBC differentiation
database_cross_reference: CL:0000232

Axiom
annotated source: erythrocyte differentiation
annotated property: has_exact_synonym
annotated target: erythropoiesis
database_cross_reference: GOC:add
database_cross_reference: GOC:dph

Axiom
annotated source: erythrocyte differentiation
annotated property: has_exact_synonym
annotated target: red blood cell differentiation
database_cross_reference: CL:0000232

chromosome condensation
type: Class
subclass of: DNA packaging
definition: The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.
has_alternative_id: GO:0000068
has_broad_synonym: DNA condensation
has_exact_synonym: eukaryotic chromosome condensation
has_exact_synonym: nuclear chromosome condensation
has_obo_namespace: biological_process
id: GO:0030261

Axiom
annotated source: chromosome condensation
annotated property: definition
annotated target: The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0815316194

Axiom
annotated source: chromosome condensation
annotated property: has_broad_synonym
annotated target: DNA condensation
database_cross_reference: Wikipedia:DNA_condensation

Axiom
annotated source: chromosome condensation
annotated property: has_exact_synonym
annotated target: eukaryotic chromosome condensation
database_cross_reference: GOC:bf

Axiom
annotated source: chromosome condensation
annotated property: has_exact_synonym
annotated target: nuclear chromosome condensation
database_cross_reference: GOC:bf

apoptotic nuclear changes
type: Class
subclass of: cellular component disassembly involved in execution phase of apoptosis
definition: Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis.
has_narrow_synonym: apoptotic nuclear change
has_obo_namespace: biological_process
id: GO:0030262

Axiom
annotated source: apoptotic nuclear changes
annotated property: definition
annotated target: Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis.
database_cross_reference: GOC:mah
database_cross_reference: GOC:mtg_apoptosis

apoptotic chromosome condensation
type: Class
subclass of: chromosome condensation
subclass of: Restriction
  on property: part of
  some values from: apoptotic nuclear changes
definition: The compaction of chromatin during apoptosis.
database_cross_reference: Wikipedia:Pyknosis
has_exact_synonym: pyknosis
has_obo_namespace: biological_process
id: GO:0030263

Axiom
annotated source: apoptotic chromosome condensation
annotated property: definition
annotated target: The compaction of chromatin during apoptosis.
database_cross_reference: GOC:mah

estrogen receptor activity
type: Class
subclass of: steroid hormone receptor activity
definition: Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function.
has_obo_namespace: molecular_function
id: GO:0030284
comment: For estrogen receptors that function within the nucleus to modulate transcription, consider instead annotating to the child terms 'estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity ; GO:0038052' or 'estrogen-activated RNA polymerase II transcription factor binding transcription factor activity ; GO:0038053'.

Axiom
annotated source: estrogen receptor activity
annotated property: definition
annotated target: Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function.
database_cross_reference: GOC:signaling
database_cross_reference: PMID:17615392

positive regulation of cell growth
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: cell growth
subclass of: regulation of cell growth
subclass of: positive regulation of growth
subclass of: positive regulation of cellular process
subclass of: Restriction
  on property: positively regulates
  some values from: cell growth
definition: Any process that activates or increases the frequency, rate, extent or direction of cell growth.
has_exact_synonym: up regulation of cell growth
has_exact_synonym: up-regulation of cell growth
has_exact_synonym: upregulation of cell growth
has_narrow_synonym: activation of cell growth
has_narrow_synonym: stimulation of cell growth
has_obo_namespace: biological_process
id: GO:0030307

Axiom
annotated source: positive regulation of cell growth
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate, extent or direction of cell growth.
database_cross_reference: GOC:go_curators

negative regulation of cell growth
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cell growth
subclass of: regulation of cell growth
subclass of: negative regulation of growth
subclass of: negative regulation of cellular process
subclass of: Restriction
  on property: negatively regulates
  some values from: cell growth
definition: Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
has_exact_synonym: down regulation of cell growth
has_exact_synonym: down-regulation of cell growth
has_exact_synonym: downregulation of cell growth
has_narrow_synonym: inhibition of cell growth
has_obo_namespace: biological_process
id: GO:0030308

Axiom
annotated source: negative regulation of cell growth
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
database_cross_reference: GOC:go_curators

external encapsulating structure
type: Class
subclass of: GO_0110165
subclass of: Restriction
  on property: part of
  some values from: GO_0071944
definition: A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space.
has_obo_namespace: cellular_component
id: GO:0030312
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant
comment: The outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria) are defined as parts of this structure, see 'external encapsulating structure part'.

Axiom
annotated source: external encapsulating structure
annotated property: definition
annotated target: A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space.
database_cross_reference: GOC:go_curators

cell envelope
type: Class
subclass of: envelope
subclass of: Restriction
  on property: has part
  some values from: plasma membrane
definition: An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present.
database_cross_reference: Wikipedia:Cell_envelope
has_obo_namespace: cellular_component
id: GO:0030313
in_subset: goslim pir

Axiom
annotated source: cell envelope
annotated property: definition
annotated target: An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present.
database_cross_reference: GOC:ds
database_cross_reference: GOC:mlg
database_cross_reference: http://pathmicro.med.sc.edu/fox/cell_envelope.htm

flagellated sperm motility
type: Class
subclass of: GO_0060285
subclass of: GO_0097722
definition: Any process involved in the controlled movement of a flagellated sperm cell.
has_broad_synonym: sperm motility
has_broad_synonym: sperm movement
database_cross_reference: Wikipedia:Sperm_motility
has_exact_synonym: flagellated sperm movement
has_obo_namespace: biological_process
id: GO:0030317

Axiom
annotated source: flagellated sperm motility
annotated property: definition
annotated target: Any process involved in the controlled movement of a flagellated sperm cell.
database_cross_reference: GOC:cilia
database_cross_reference: GOC:jl
database_cross_reference: GOC:krc

host cell cytoplasm
type: Class
subclass of: host intracellular part
definition: The cytoplasm of a host cell.
created by: paola
creation date: 2014-12-01T14:14:21Z
has_alternative_id: GO:0097679
has_obo_namespace: cellular_component
has_related_synonym: other organism cytoplasm
id: GO:0030430

Axiom
annotated source: host cell cytoplasm
annotated property: definition
annotated target: The cytoplasm of a host cell.
database_cross_reference: GOC:mah

sleep
type: Class
subclass of: multicellular organismal process
definition: Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.
database_cross_reference: Wikipedia:Sleep
has_obo_namespace: biological_process
has_related_synonym: diapause
has_related_synonym: dormancy
has_related_synonym: lethargus
id: GO:0030431
in_subset: goslim pir

Axiom
annotated source: sleep
annotated property: definition
annotated target: Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.
database_cross_reference: ISBN:0192800981

intracellular receptor signaling pathway
type: Class
subclass of: signal transduction
definition: Any series of molecular signals initiated by a ligand binding to an receptor located within a cell.
has_exact_synonym: intracellular receptor mediated signaling pathway
has_exact_synonym: intracellular receptor-mediated signaling pathway
has_exact_synonym: intracellular receptor-mediated signalling pathway
has_obo_namespace: biological_process
id: GO:0030522

Axiom
annotated source: intracellular receptor signaling pathway
annotated property: definition
annotated target: Any series of molecular signals initiated by a ligand binding to an receptor located within a cell.
database_cross_reference: GOC:bf
database_cross_reference: GOC:mah

receptor regulator activity
type: Class
subclass of: GO_0098772
definition: The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is changed.
database_cross_reference: MIPS_funcat:18.02.07
has_obo_namespace: molecular_function
id: GO:0030545

Axiom
annotated source: receptor regulator activity
annotated property: definition
annotated target: The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is changed.
database_cross_reference: GOC:ceb

signaling receptor activator activity
type: Class
subclass of: receptor regulator activity
definition: The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased.
has_broad_synonym: receptor activator activity
has_obo_namespace: molecular_function
id: GO:0030546

Axiom
annotated source: signaling receptor activator activity
annotated property: definition
annotated target: The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased.
database_cross_reference: GOC:ceb

symbiont intracellular protein transport in host
type: Class
equivalent class: Class
  intersection of: protein transport
  intersection of: Restriction
    on property: occurs in
    some values from: host cell
subclass of: protein transport
subclass of: GO_0051701
subclass of: Restriction
  on property: occurs in
  some values from: host cell
definition: The directed movement of a symbiont's proteins within a cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has_alternative_id: GO:0051708
has_broad_synonym: intracellular protein transport in other organism during symbiotic interaction
has_broad_synonym: intracellular protein transport in other organism involved in symbiotic interaction
has_exact_synonym: host cell protein transport
has_exact_synonym: intracellular protein transport in host
has_obo_namespace: biological_process
id: GO:0030581

Axiom
annotated source: symbiont intracellular protein transport in host
annotated property: definition
annotated target: The directed movement of a symbiont's proteins within a cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
database_cross_reference: GOC:mb

Axiom
annotated source: symbiont intracellular protein transport in host
annotated property: has_broad_synonym
annotated target: intracellular protein transport in other organism during symbiotic interaction
database_cross_reference: GOC:dph

regulation of vitamin metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: vitamin metabolic process
subclass of: GO_0062012
subclass of: Restriction
  on property: regulates
  some values from: vitamin metabolic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.
has_exact_synonym: regulation of vitamin metabolism
has_obo_namespace: biological_process
id: GO:0030656

Axiom
annotated source: regulation of vitamin metabolic process
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.
database_cross_reference: GOC:mah

transport vesicle membrane
type: Class
subclass of: cytoplasmic vesicle membrane
subclass of: GO_0098588
subclass of: GO_0098805
subclass of: Restriction
  on property: part of
  some values from: transport vesicle
definition: The lipid bilayer surrounding a transport vesicle.
has_broad_synonym: secretory vesicle membrane
has_exact_synonym: constitutive secretory pathway transport vesicle membrane
has_obo_namespace: cellular_component
id: GO:0030658

Axiom
annotated source: transport vesicle membrane
annotated property: definition
annotated target: The lipid bilayer surrounding a transport vesicle.
database_cross_reference: GOC:mah

cytoplasmic vesicle membrane
type: Class
subclass of: vesicle membrane
subclass of: Restriction
  on property: part of
  some values from: cytoplasmic vesicle
definition: The lipid bilayer surrounding a cytoplasmic vesicle.
has_obo_namespace: cellular_component
id: GO:0030659

Axiom
annotated source: cytoplasmic vesicle membrane
annotated property: definition
annotated target: The lipid bilayer surrounding a cytoplasmic vesicle.
database_cross_reference: GOC:mah

Golgi-associated vesicle membrane
type: Class
subclass of: GO_0098588
subclass of: GO_0098805
subclass of: Restriction
  on property: part of
  some values from: Golgi-associated vesicle
definition: The lipid bilayer surrounding a vesicle associated with the Golgi apparatus.
has_obo_namespace: cellular_component
has_related_synonym: Golgi vesicle membrane
id: GO:0030660

Axiom
annotated source: Golgi-associated vesicle membrane
annotated property: definition
annotated target: The lipid bilayer surrounding a vesicle associated with the Golgi apparatus.
database_cross_reference: GOC:mah

coated vesicle membrane
type: Class
subclass of: cytoplasmic vesicle membrane
subclass of: GO_0098588
subclass of: GO_0098805
subclass of: Restriction
  on property: part of
  some values from: coated vesicle
definition: The lipid bilayer surrounding a coated vesicle.
has_obo_namespace: cellular_component
id: GO:0030662

Axiom
annotated source: coated vesicle membrane
annotated property: definition
annotated target: The lipid bilayer surrounding a coated vesicle.
database_cross_reference: GOC:mah

secretory granule membrane
type: Class
subclass of: cytoplasmic vesicle membrane
subclass of: GO_0098588
subclass of: GO_0098805
subclass of: Restriction
  on property: part of
  some values from: secretory granule
definition: The lipid bilayer surrounding a secretory granule.
has_broad_synonym: secretory vesicle membrane
has_obo_namespace: cellular_component
id: GO:0030667

Axiom
annotated source: secretory granule membrane
annotated property: definition
annotated target: The lipid bilayer surrounding a secretory granule.
database_cross_reference: GOC:mah

cytoskeleton-dependent intracellular transport
type: Class
subclass of: intracellular transport
definition: The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell.
has_obo_namespace: biological_process
id: GO:0030705
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic

Axiom
annotated source: cytoskeleton-dependent intracellular transport
annotated property: definition
annotated target: The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell.
database_cross_reference: GOC:mah

ovulation
type: Class
subclass of: multicellular organismal reproductive process
subclass of: Restriction
  on property: part of
  some values from: female gamete generation
definition: The release of a mature ovum/oocyte from an ovary.
database_cross_reference: Wikipedia:Ovulation
has_obo_namespace: biological_process
id: GO:0030728

Axiom
annotated source: ovulation
annotated property: definition
annotated target: The release of a mature ovum/oocyte from an ovary.
database_cross_reference: GOC:bf
database_cross_reference: ISBN:0878932437

regulation of nucleotide biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: nucleotide biosynthetic process
subclass of: regulation of nucleotide metabolic process
subclass of: regulation of cellular biosynthetic process
subclass of: Restriction
  on property: regulates
  some values from: nucleotide biosynthetic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides.
has_exact_synonym: regulation of nucleotide anabolism
has_exact_synonym: regulation of nucleotide biosynthesis
has_exact_synonym: regulation of nucleotide formation
has_exact_synonym: regulation of nucleotide synthesis
has_obo_namespace: biological_process
id: GO:0030808

Axiom
annotated source: regulation of nucleotide biosynthetic process
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides.
database_cross_reference: GOC:mah

negative regulation of nucleotide biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: nucleotide biosynthetic process
subclass of: regulation of nucleotide biosynthetic process
subclass of: negative regulation of cellular biosynthetic process
subclass of: negative regulation of nucleotide metabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: nucleotide biosynthetic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides.
has_exact_synonym: down regulation of nucleotide biosynthetic process
has_exact_synonym: down-regulation of nucleotide biosynthetic process
has_exact_synonym: downregulation of nucleotide biosynthetic process
has_exact_synonym: negative regulation of nucleotide anabolism
has_exact_synonym: negative regulation of nucleotide biosynthesis
has_exact_synonym: negative regulation of nucleotide formation
has_exact_synonym: negative regulation of nucleotide synthesis
has_narrow_synonym: inhibition of nucleotide biosynthetic process
has_obo_namespace: biological_process
id: GO:0030809

Axiom
annotated source: negative regulation of nucleotide biosynthetic process
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides.
database_cross_reference: GOC:mah

positive regulation of nucleotide biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: nucleotide biosynthetic process
subclass of: regulation of nucleotide biosynthetic process
subclass of: positive regulation of cellular biosynthetic process
subclass of: positive regulation of nucleotide metabolic process
subclass of: Restriction
  on property: positively regulates
  some values from: nucleotide biosynthetic process
definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides.
has_exact_synonym: positive regulation of nucleotide anabolism
has_exact_synonym: positive regulation of nucleotide biosynthesis
has_exact_synonym: positive regulation of nucleotide formation
has_exact_synonym: positive regulation of nucleotide synthesis
has_exact_synonym: up regulation of nucleotide biosynthetic process
has_exact_synonym: up-regulation of nucleotide biosynthetic process
has_exact_synonym: upregulation of nucleotide biosynthetic process
has_narrow_synonym: activation of nucleotide biosynthetic process
has_narrow_synonym: stimulation of nucleotide biosynthetic process
has_obo_namespace: biological_process
id: GO:0030810

Axiom
annotated source: positive regulation of nucleotide biosynthetic process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides.
database_cross_reference: GOC:mah

intraciliary transport particle
type: Class
subclass of: protein-containing complex
definition: A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules.
has_exact_synonym: intraflagellar transport complex
has_exact_synonym: intraflagellar transport particle
has_obo_namespace: cellular_component
has_related_synonym: IFT complex
id: GO:0030990
in_subset: goslim pir
comment: Note that we deem cilia and microtubule-based flagella to be equivalent.

Axiom
annotated source: intraciliary transport particle
annotated property: definition
annotated target: A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules.
database_cross_reference: GOC:cilia
database_cross_reference: GOC:kmv
database_cross_reference: PMID:14570576
database_cross_reference: PMID:22118932
database_cross_reference: PMID:23945166

extracellular matrix
type: Class
subclass of: GO_0110165
subclass of: Restriction
  on property: part of
  some values from: extracellular region
definition: A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
has_alternative_id: GO:0005578
database_cross_reference: NIF_Subcellular:nlx_subcell_20090513
database_cross_reference: Wikipedia:Extracellular_matrix
has_exact_synonym: proteinaceous extracellular matrix
has_narrow_synonym: matrisome
has_obo_namespace: cellular_component
id: GO:0031012
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir

Axiom
annotated source: extracellular matrix
annotated property: definition
annotated target: A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:mah
database_cross_reference: GOC:rph
database_cross_reference: NIF_Subcellular:nlx_subcell_20090513
database_cross_reference: PMID:21123617
database_cross_reference: PMID:28089324

gene silencing by RNA
type: Class
subclass of: gene silencing
definition: Any process in which RNA molecules inactivate expression of target genes.
has_exact_synonym: RNA-mediated gene silencing
has_obo_namespace: biological_process
id: GO:0031047

Axiom
annotated source: gene silencing by RNA
annotated property: definition
annotated target: Any process in which RNA molecules inactivate expression of target genes.
database_cross_reference: GOC:dph
database_cross_reference: GOC:mah
database_cross_reference: GOC:tb
database_cross_reference: PMID:15020054

Axiom
annotated source: gene silencing by RNA
annotated property: has_exact_synonym
annotated target: RNA-mediated gene silencing
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

programmed DNA elimination
type: Class
subclass of: DNA metabolic process
definition: The DNA metabolic process in which micronuclear-limited sequences, internal eliminated sequences (IES) and breakage eliminated sequences (BES) are removed from the developing macronucleus (anlage) of a ciliate.
has_obo_namespace: biological_process
id: GO:0031049
in_subset: goslim pir

Axiom
annotated source: programmed DNA elimination
annotated property: definition
annotated target: The DNA metabolic process in which micronuclear-limited sequences, internal eliminated sequences (IES) and breakage eliminated sequences (BES) are removed from the developing macronucleus (anlage) of a ciliate.
database_cross_reference: GOC:mah
database_cross_reference: GOC:ns

chromosome breakage
type: Class
subclass of: GO_0051276
subclass of: Restriction
  on property: part of
  some values from: programmed DNA elimination
definition: Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage.
has_exact_synonym: establishment or maintenance of heterochromatin architecture
has_obo_namespace: biological_process
id: GO:0031052
comment: Note that this term refers to breakage of chromosomes during normal DNA rearrangements characteristic of ciliates; it is not to be used for DNA damage or other abnormal occurrences.

Axiom
annotated source: chromosome breakage
annotated property: definition
annotated target: Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage.
database_cross_reference: GOC:ns

Axiom
annotated source: chromosome breakage
annotated property: has_exact_synonym
annotated target: establishment or maintenance of heterochromatin architecture
database_cross_reference: GOC:mah

organelle membrane
type: Class
subclass of: membrane
subclass of: Restriction
  on property: part of
  some values from: membrane-bounded organelle
definition: A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.
database_cross_reference: NIF_Subcellular:sao830981606
has_obo_namespace: cellular_component
has_related_synonym: intracellular membrane
id: GO:0031090

Axiom
annotated source: organelle membrane
annotated property: definition
annotated target: A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.
database_cross_reference: GOC:dos
database_cross_reference: GOC:mah

Axiom
annotated source: organelle membrane
annotated property: has_related_synonym
annotated target: intracellular membrane
database_cross_reference: NIF_Subcellular:sao830981606

neuron projection development
type: Class
equivalent class: Class
  intersection of: GO_0120036
  intersection of: Restriction
    on property: part of
    some values from: neuron development
subclass of: GO_0120036
subclass of: Restriction
  on property: part of
  some values from: neuron development
definition: The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
has_narrow_synonym: neurite biosynthesis
has_narrow_synonym: neurite development
has_narrow_synonym: neurite formation
has_narrow_synonym: neurite growth
has_narrow_synonym: neurite outgrowth
has_obo_namespace: biological_process
id: GO:0031175

Axiom
annotated source: neuron projection development
annotated property: definition
annotated target: The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
database_cross_reference: GOC:mah

Axiom
annotated source: neuron projection development
annotated property: has_narrow_synonym
annotated target: neurite development
database_cross_reference: GOC:dph

pseudopodium organization
type: Class
subclass of: GO_0120036
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement.
has_exact_synonym: pseudopodium organisation
has_obo_namespace: biological_process
has_related_synonym: pseudopodium organization and biogenesis
id: GO:0031268

Axiom
annotated source: pseudopodium organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement.
database_cross_reference: GOC:pg

Axiom
annotated source: pseudopodium organization
annotated property: has_related_synonym
annotated target: pseudopodium organization and biogenesis
database_cross_reference: GOC:mah

regulation of cellular metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cellular metabolic process
subclass of: regulation of metabolic process
subclass of: GO_0050794
subclass of: Restriction
  on property: regulates
  some values from: cellular metabolic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
has_exact_synonym: regulation of cellular metabolism
has_obo_namespace: biological_process
id: GO:0031323

Axiom
annotated source: regulation of cellular metabolic process
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
database_cross_reference: GOC:mah

negative regulation of cellular metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cellular metabolic process
subclass of: negative regulation of metabolic process
subclass of: regulation of cellular metabolic process
subclass of: negative regulation of cellular process
subclass of: Restriction
  on property: negatively regulates
  some values from: cellular metabolic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
has_exact_synonym: down regulation of cellular metabolic process
has_exact_synonym: down-regulation of cellular metabolic process
has_exact_synonym: downregulation of cellular metabolic process
has_exact_synonym: negative regulation of cellular metabolism
has_narrow_synonym: inhibition of cellular metabolic process
has_obo_namespace: biological_process
id: GO:0031324

Axiom
annotated source: negative regulation of cellular metabolic process
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
database_cross_reference: GOC:mah

positive regulation of cellular metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: cellular metabolic process
subclass of: positive regulation of metabolic process
subclass of: regulation of cellular metabolic process
subclass of: positive regulation of cellular process
subclass of: Restriction
  on property: positively regulates
  some values from: cellular metabolic process
definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
has_exact_synonym: positive regulation of cellular metabolism
has_exact_synonym: up regulation of cellular metabolic process
has_exact_synonym: up-regulation of cellular metabolic process
has_exact_synonym: upregulation of cellular metabolic process
has_narrow_synonym: activation of cellular metabolic process
has_narrow_synonym: stimulation of cellular metabolic process
has_obo_namespace: biological_process
id: GO:0031325

Axiom
annotated source: positive regulation of cellular metabolic process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
database_cross_reference: GOC:mah

regulation of cellular biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cellular biosynthetic process
subclass of: regulation of biosynthetic process
subclass of: regulation of cellular metabolic process
subclass of: Restriction
  on property: regulates
  some values from: cellular biosynthetic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
has_exact_synonym: regulation of cellular anabolism
has_exact_synonym: regulation of cellular biosynthesis
has_exact_synonym: regulation of cellular formation
has_exact_synonym: regulation of cellular synthesis
has_obo_namespace: biological_process
id: GO:0031326

Axiom
annotated source: regulation of cellular biosynthetic process
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
database_cross_reference: GOC:mah

negative regulation of cellular biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cellular biosynthetic process
subclass of: negative regulation of biosynthetic process
subclass of: negative regulation of cellular metabolic process
subclass of: regulation of cellular biosynthetic process
subclass of: Restriction
  on property: negatively regulates
  some values from: cellular biosynthetic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
has_exact_synonym: down regulation of cellular biosynthetic process
has_exact_synonym: down-regulation of cellular biosynthetic process
has_exact_synonym: downregulation of cellular biosynthetic process
has_exact_synonym: negative regulation of cellular anabolism
has_exact_synonym: negative regulation of cellular biosynthesis
has_exact_synonym: negative regulation of cellular formation
has_exact_synonym: negative regulation of cellular synthesis
has_narrow_synonym: inhibition of cellular biosynthetic process
has_obo_namespace: biological_process
id: GO:0031327

Axiom
annotated source: negative regulation of cellular biosynthetic process
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
database_cross_reference: GOC:mah

positive regulation of cellular biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: cellular biosynthetic process
subclass of: positive regulation of biosynthetic process
subclass of: positive regulation of cellular metabolic process
subclass of: regulation of cellular biosynthetic process
subclass of: Restriction
  on property: positively regulates
  some values from: cellular biosynthetic process
definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
has_exact_synonym: positive regulation of cellular anabolism
has_exact_synonym: positive regulation of cellular biosynthesis
has_exact_synonym: positive regulation of cellular formation
has_exact_synonym: positive regulation of cellular synthesis
has_exact_synonym: up regulation of cellular biosynthetic process
has_exact_synonym: up-regulation of cellular biosynthetic process
has_exact_synonym: upregulation of cellular biosynthetic process
has_narrow_synonym: activation of cellular biosynthetic process
has_narrow_synonym: stimulation of cellular biosynthetic process
has_obo_namespace: biological_process
id: GO:0031328

Axiom
annotated source: positive regulation of cellular biosynthetic process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
database_cross_reference: GOC:mah

regulation of cellular catabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cellular catabolic process
subclass of: regulation of catabolic process
subclass of: regulation of cellular metabolic process
subclass of: Restriction
  on property: regulates
  some values from: cellular catabolic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
has_exact_synonym: regulation of cellular breakdown
has_exact_synonym: regulation of cellular catabolism
has_exact_synonym: regulation of cellular degradation
has_obo_namespace: biological_process
id: GO:0031329

Axiom
annotated source: regulation of cellular catabolic process
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
database_cross_reference: GOC:mah

negative regulation of cellular catabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cellular catabolic process
subclass of: negative regulation of catabolic process
subclass of: negative regulation of cellular metabolic process
subclass of: regulation of cellular catabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: cellular catabolic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
has_exact_synonym: down regulation of cellular catabolic process
has_exact_synonym: down-regulation of cellular catabolic process
has_exact_synonym: downregulation of cellular catabolic process
has_exact_synonym: negative regulation of cellular breakdown
has_exact_synonym: negative regulation of cellular catabolism
has_exact_synonym: negative regulation of cellular degradation
has_narrow_synonym: inhibition of cellular catabolic process
has_obo_namespace: biological_process
id: GO:0031330

Axiom
annotated source: negative regulation of cellular catabolic process
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
database_cross_reference: GOC:mah

positive regulation of cellular catabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: cellular catabolic process
subclass of: positive regulation of catabolic process
subclass of: positive regulation of cellular metabolic process
subclass of: regulation of cellular catabolic process
subclass of: Restriction
  on property: positively regulates
  some values from: cellular catabolic process
definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
has_exact_synonym: positive regulation of cellular breakdown
has_exact_synonym: positive regulation of cellular catabolism
has_exact_synonym: positive regulation of cellular degradation
has_exact_synonym: up regulation of cellular catabolic process
has_exact_synonym: up-regulation of cellular catabolic process
has_exact_synonym: upregulation of cellular catabolic process
has_narrow_synonym: activation of cellular catabolic process
has_narrow_synonym: stimulation of cellular catabolic process
has_obo_namespace: biological_process
id: GO:0031331

Axiom
annotated source: positive regulation of cellular catabolic process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
database_cross_reference: GOC:mah

negative regulation of protein-containing complex assembly
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: GO_0065003
subclass of: regulation of protein-containing complex assembly
subclass of: GO_0051129
subclass of: Restriction
  on property: negatively regulates
  some values from: GO_0065003
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly.
has_exact_synonym: down regulation of protein complex assembly
has_exact_synonym: down-regulation of protein complex assembly
has_exact_synonym: downregulation of protein complex assembly
has_narrow_synonym: inhibition of protein complex assembly
has_obo_namespace: biological_process
has_related_synonym: negative regulation of protein complex assembly
id: GO:0031333

Axiom
annotated source: negative regulation of protein-containing complex assembly
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly.
database_cross_reference: GOC:mah

positive regulation of protein-containing complex assembly
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: GO_0065003
subclass of: regulation of protein-containing complex assembly
subclass of: positive regulation of cellular component biogenesis
subclass of: GO_0051130
subclass of: Restriction
  on property: positively regulates
  some values from: GO_0065003
definition: Any process that activates or increases the frequency, rate or extent of protein complex assembly.
has_exact_synonym: up regulation of protein complex assembly
has_exact_synonym: up-regulation of protein complex assembly
has_exact_synonym: upregulation of protein complex assembly
has_narrow_synonym: activation of protein complex assembly
has_narrow_synonym: stimulation of protein complex assembly
has_obo_namespace: biological_process
has_related_synonym: positive regulation of protein complex assembly
id: GO:0031334

Axiom
annotated source: positive regulation of protein-containing complex assembly
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of protein complex assembly.
database_cross_reference: GOC:mah

regulation of cell killing
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cell killing
subclass of: GO_0050794
subclass of: Restriction
  on property: regulates
  some values from: cell killing
definition: Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism.
has_obo_namespace: biological_process
id: GO:0031341

Axiom
annotated source: regulation of cell killing
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism.
database_cross_reference: GOC:mah

negative regulation of cell killing
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cell killing
subclass of: regulation of cell killing
subclass of: negative regulation of cellular process
subclass of: Restriction
  on property: negatively regulates
  some values from: cell killing
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of cell killing.
has_exact_synonym: down regulation of cell killing
has_exact_synonym: down-regulation of cell killing
has_exact_synonym: downregulation of cell killing
has_narrow_synonym: inhibition of cell killing
has_obo_namespace: biological_process
id: GO:0031342

Axiom
annotated source: negative regulation of cell killing
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of cell killing.
database_cross_reference: GOC:mah

positive regulation of cell killing
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: cell killing
subclass of: regulation of cell killing
subclass of: positive regulation of cellular process
subclass of: Restriction
  on property: positively regulates
  some values from: cell killing
definition: Any process that activates or increases the frequency, rate or extent of cell killing.
has_exact_synonym: up regulation of cell killing
has_exact_synonym: up-regulation of cell killing
has_exact_synonym: upregulation of cell killing
has_narrow_synonym: activation of cell killing
has_narrow_synonym: stimulation of cell killing
has_obo_namespace: biological_process
id: GO:0031343

Axiom
annotated source: positive regulation of cell killing
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of cell killing.
database_cross_reference: GOC:mah

regulation of cell projection organization
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cell projection organization
subclass of: GO_0051128
subclass of: Restriction
  on property: regulates
  some values from: cell projection organization
definition: Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.
has_exact_synonym: regulation of cell projection organisation
has_obo_namespace: biological_process
has_related_synonym: regulation of cell projection organization and biogenesis
id: GO:0031344

Axiom
annotated source: regulation of cell projection organization
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.
database_cross_reference: GOC:mah

Axiom
annotated source: regulation of cell projection organization
annotated property: has_related_synonym
annotated target: regulation of cell projection organization and biogenesis
database_cross_reference: GOC:mah

negative regulation of cell projection organization
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cell projection organization
subclass of: regulation of cell projection organization
subclass of: GO_0051129
subclass of: Restriction
  on property: negatively regulates
  some values from: cell projection organization
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.
has_exact_synonym: down regulation of cell projection organization
has_exact_synonym: down-regulation of cell projection organization
has_exact_synonym: downregulation of cell projection organization
has_exact_synonym: negative regulation of cell projection organisation
has_narrow_synonym: inhibition of cell projection organization
has_obo_namespace: biological_process
has_related_synonym: negative regulation of cell projection organization and biogenesis
id: GO:0031345

Axiom
annotated source: negative regulation of cell projection organization
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.
database_cross_reference: GOC:mah

Axiom
annotated source: negative regulation of cell projection organization
annotated property: has_exact_synonym
annotated target: down regulation of cell projection organization
database_cross_reference: GOC:mah

Axiom
annotated source: negative regulation of cell projection organization
annotated property: has_related_synonym
annotated target: negative regulation of cell projection organization and biogenesis
database_cross_reference: GOC:mah

positive regulation of cell projection organization
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: cell projection organization
subclass of: regulation of cell projection organization
subclass of: GO_0051130
subclass of: Restriction
  on property: positively regulates
  some values from: cell projection organization
definition: Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.
has_exact_synonym: positive regulation of cell projection organisation
has_exact_synonym: up regulation of cell projection organization
has_exact_synonym: up-regulation of cell projection organization
has_exact_synonym: upregulation of cell projection organization
has_narrow_synonym: activation of cell projection organization
has_narrow_synonym: stimulation of cell projection organization
has_obo_namespace: biological_process
has_related_synonym: positive regulation of cell projection organization and biogenesis
id: GO:0031346

Axiom
annotated source: positive regulation of cell projection organization
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.
database_cross_reference: GOC:mah

Axiom
annotated source: positive regulation of cell projection organization
annotated property: has_related_synonym
annotated target: positive regulation of cell projection organization and biogenesis
database_cross_reference: GOC:mah

regulation of defense response
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: defense response
subclass of: GO_0080134
subclass of: Restriction
  on property: regulates
  some values from: defense response
definition: Any process that modulates the frequency, rate or extent of a defense response.
has_obo_namespace: biological_process
id: GO:0031347

Axiom
annotated source: regulation of defense response
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of a defense response.
database_cross_reference: GOC:mah

negative regulation of defense response
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: defense response
subclass of: regulation of defense response
subclass of: negative regulation of response to stimulus
subclass of: Restriction
  on property: negatively regulates
  some values from: defense response
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response.
has_exact_synonym: down regulation of defense response
has_exact_synonym: down-regulation of defense response
has_exact_synonym: downregulation of defense response
has_narrow_synonym: inhibition of defense response
has_obo_namespace: biological_process
id: GO:0031348

Axiom
annotated source: negative regulation of defense response
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response.
database_cross_reference: GOC:mah

positive regulation of defense response
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: defense response
subclass of: regulation of defense response
subclass of: positive regulation of response to stimulus
subclass of: Restriction
  on property: positively regulates
  some values from: defense response
definition: Any process that activates or increases the frequency, rate or extent of a defense response.
has_exact_synonym: up regulation of defense response
has_exact_synonym: up-regulation of defense response
has_exact_synonym: upregulation of defense response
has_narrow_synonym: activation of defense response
has_narrow_synonym: stimulation of defense response
has_obo_namespace: biological_process
id: GO:0031349

Axiom
annotated source: positive regulation of defense response
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of a defense response.
database_cross_reference: GOC:mah

regulation of protein modification process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cellular protein modification process
subclass of: regulation of cellular protein metabolic process
subclass of: Restriction
  on property: regulates
  some values from: cellular protein modification process
definition: Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.
has_obo_namespace: biological_process
id: GO:0031399
in_subset: goslim yeast

Axiom
annotated source: regulation of protein modification process
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.
database_cross_reference: GOC:mah
database_cross_reference: GOC:tb

negative regulation of protein modification process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cellular protein modification process
subclass of: regulation of protein modification process
subclass of: negative regulation of cellular protein metabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: cellular protein modification process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.
has_exact_synonym: down regulation of protein modification
has_exact_synonym: down-regulation of protein modification
has_exact_synonym: downregulation of protein modification
has_narrow_synonym: inhibition of protein modification
has_obo_namespace: biological_process
id: GO:0031400

Axiom
annotated source: negative regulation of protein modification process
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.
database_cross_reference: GOC:mah
database_cross_reference: GOC:tb

positive regulation of protein modification process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: cellular protein modification process
subclass of: regulation of protein modification process
subclass of: positive regulation of cellular protein metabolic process
subclass of: Restriction
  on property: positively regulates
  some values from: cellular protein modification process
definition: Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.
has_exact_synonym: up regulation of protein modification
has_exact_synonym: up-regulation of protein modification
has_exact_synonym: upregulation of protein modification
has_narrow_synonym: activation of protein modification
has_narrow_synonym: stimulation of protein modification
has_obo_namespace: biological_process
id: GO:0031401

Axiom
annotated source: positive regulation of protein modification process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.
database_cross_reference: GOC:mah
database_cross_reference: GOC:tb

cytoplasmic vesicle
type: Class
equivalent class: Class
  intersection of: vesicle
  intersection of: Restriction
    on property: part of
    some values from: cytoplasm
subclass of: GO_0097708
subclass of: Restriction
  on property: part of
  some values from: cytoplasm
definition: A vesicle found in the cytoplasm of a cell.
has_alternative_id: GO:0016023
database_cross_reference: NIF_Subcellular:sao180601769
has_obo_namespace: cellular_component
has_related_synonym: cytoplasmic membrane bounded vesicle
has_related_synonym: cytoplasmic membrane-enclosed vesicle
has_related_synonym: cytoplasmic, membrane-bounded vesicle
id: GO:0031410
in_subset: goslim agr
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim yeast

Axiom
annotated source: cytoplasmic vesicle
annotated property: definition
annotated target: A vesicle found in the cytoplasm of a cell.
database_cross_reference: GOC:ai
database_cross_reference: GOC:mah
database_cross_reference: GOC:vesicles

response to methotrexate
type: Class
subclass of: response to acid chemical
subclass of: response to organonitrogen compound
subclass of: response to organic cyclic compound
subclass of: GO_0097327
subclass of: GO_0097329
subclass of: GO_1901700
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase.
has_obo_namespace: biological_process
id: GO:0031427

Axiom
annotated source: response to methotrexate
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase.
database_cross_reference: GOC:ef
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0198506732

protein-containing complex localization
type: Class
subclass of: protein localization
definition: A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location.
has_exact_synonym: establishment and maintenance of protein complex localization
has_exact_synonym: protein complex localisation
has_obo_namespace: biological_process
has_related_synonym: protein complex localization
id: GO:0031503

Axiom
annotated source: protein-containing complex localization
annotated property: definition
annotated target: A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location.
database_cross_reference: GOC:mah

Axiom
annotated source: protein-containing complex localization
annotated property: has_exact_synonym
annotated target: protein complex localisation
database_cross_reference: GOC:mah

killing of cells of other organism
type: Class
subclass of: cell killing
definition: Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.
has_alternative_id: GO:0001908
has_exact_synonym: killing of cells of another organism
has_narrow_synonym: killing of cells of another, non-host, organism
has_obo_namespace: biological_process
id: GO:0031640
in_subset: goslim pir

Axiom
annotated source: killing of cells of other organism
annotated property: definition
annotated target: Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.
database_cross_reference: GOC:add

Axiom
annotated source: killing of cells of other organism
annotated property: has_exact_synonym
annotated target: killing of cells of another organism
database_cross_reference: GOC:bf

regulation of nervous system process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: GO_0050877
subclass of: regulation of system process
subclass of: Restriction
  on property: regulates
  some values from: GO_0050877
definition: Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system.
has_exact_synonym: regulation of neurological process
has_exact_synonym: regulation of neurological system process
has_exact_synonym: regulation of neurophysiological process
has_obo_namespace: biological_process
id: GO:0031644

Axiom
annotated source: regulation of nervous system process
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system.
database_cross_reference: GOC:dph
database_cross_reference: GOC:mah
database_cross_reference: GOC:tb

Axiom
annotated source: regulation of nervous system process
annotated property: has_exact_synonym
annotated target: regulation of neurological process
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

negative regulation of nervous system process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: GO_0050877
subclass of: regulation of nervous system process
subclass of: GO_0051241
subclass of: Restriction
  on property: negatively regulates
  some values from: GO_0050877
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process.
has_exact_synonym: down regulation of neurological process
has_exact_synonym: down-regulation of neurological process
has_exact_synonym: downregulation of neurological process
has_exact_synonym: negative regulation of neurological process
has_exact_synonym: negative regulation of neurological system process
has_exact_synonym: negative regulation of neurophysiological process
has_narrow_synonym: inhibition of neurological process
has_obo_namespace: biological_process
id: GO:0031645

Axiom
annotated source: negative regulation of nervous system process
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process.
database_cross_reference: GOC:dph
database_cross_reference: GOC:mah
database_cross_reference: GOC:tb

Axiom
annotated source: negative regulation of nervous system process
annotated property: has_exact_synonym
annotated target: negative regulation of neurological process
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

positive regulation of nervous system process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: GO_0050877
subclass of: regulation of nervous system process
subclass of: GO_0051240
subclass of: Restriction
  on property: positively regulates
  some values from: GO_0050877
definition: Any process that activates or increases the frequency, rate or extent of a neurophysiological process.
has_exact_synonym: positive regulation of neurological process
has_exact_synonym: positive regulation of neurological system process
has_exact_synonym: positive regulation of neurophysiological process
has_exact_synonym: up regulation of neurological process
has_exact_synonym: up-regulation of neurological process
has_exact_synonym: upregulation of neurological process
has_narrow_synonym: activation of neurological process
has_narrow_synonym: stimulation of neurological process
has_obo_namespace: biological_process
id: GO:0031646

Axiom
annotated source: positive regulation of nervous system process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of a neurophysiological process.
database_cross_reference: GOC:dph
database_cross_reference: GOC:mah
database_cross_reference: GOC:tb

Axiom
annotated source: positive regulation of nervous system process
annotated property: has_exact_synonym
annotated target: positive regulation of neurological process
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

response to nutrient levels
type: Class
subclass of: response to extracellular stimulus
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
has_obo_namespace: biological_process
id: GO:0031667

Axiom
annotated source: response to nutrient levels
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
database_cross_reference: GOC:mah

cellular response to extracellular stimulus
type: Class
subclass of: cell communication
subclass of: response to extracellular stimulus
subclass of: GO_0051716
subclass of: GO_0071496
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.
has_obo_namespace: biological_process
id: GO:0031668

Axiom
annotated source: cellular response to extracellular stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.
database_cross_reference: GOC:mah

cellular response to nutrient levels
type: Class
subclass of: response to nutrient levels
subclass of: cellular response to extracellular stimulus
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
has_obo_namespace: biological_process
id: GO:0031669

Axiom
annotated source: cellular response to nutrient levels
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
database_cross_reference: GOC:mah

response to corticosteroid
type: Class
subclass of: response to steroid hormone
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids.
has_exact_synonym: response to corticosteroid stimulus
has_obo_namespace: biological_process
id: GO:0031960

Axiom
annotated source: response to corticosteroid
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids.
database_cross_reference: GOC:mah
database_cross_reference: PMID:11027914

Axiom
annotated source: response to corticosteroid
annotated property: has_exact_synonym
annotated target: response to corticosteroid stimulus
database_cross_reference: GOC:dos

organelle envelope
type: Class
subclass of: envelope
subclass of: Restriction
  on property: part of
  some values from: membrane-bounded organelle
subclass of: Restriction
  on property: part of
  some values from: intracellular organelle
definition: A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.
has_obo_namespace: cellular_component
id: GO:0031967
in_subset: goslim mouse

Axiom
annotated source: organelle envelope
annotated property: definition
annotated target: A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.
database_cross_reference: GOC:mah
database_cross_reference: GOC:pz

chloroplast membrane
type: Class
subclass of: plastid membrane
subclass of: Restriction
  on property: part of
  some values from: chloroplast envelope
definition: Either of the lipid bilayers that surround a chloroplast and form the chloroplast envelope.
database_cross_reference: Wikipedia:Chloroplast_membrane
has_obo_namespace: cellular_component
id: GO:0031969

Axiom
annotated source: chloroplast membrane
annotated property: definition
annotated target: Either of the lipid bilayers that surround a chloroplast and form the chloroplast envelope.
database_cross_reference: GOC:mah
database_cross_reference: GOC:pz

organelle envelope lumen
type: Class
subclass of: GO_0070013
subclass of: Restriction
  on property: part of
  some values from: organelle envelope
definition: The region between the inner and outer lipid bilayers of an organelle envelope.
has_exact_synonym: organelle intermembrane space
has_obo_namespace: cellular_component
id: GO:0031970

Axiom
annotated source: organelle envelope lumen
annotated property: definition
annotated target: The region between the inner and outer lipid bilayers of an organelle envelope.
database_cross_reference: GOC:mah

membrane-enclosed lumen
type: Class
subclass of: GO_0110165
definition: The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.
has_obo_namespace: cellular_component
id: GO:0031974

Axiom
annotated source: membrane-enclosed lumen
annotated property: definition
annotated target: The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.
database_cross_reference: GOC:add
database_cross_reference: GOC:mah

envelope
type: Class
subclass of: GO_0110165
definition: A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers.
has_obo_namespace: cellular_component
id: GO:0031975

Axiom
annotated source: envelope
annotated property: definition
annotated target: A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers.
database_cross_reference: GOC:mah
database_cross_reference: GOC:pz

plastid thylakoid
type: Class
equivalent class: Class
  intersection of: thylakoid
  intersection of: Restriction
    on property: part of
    some values from: plastid
subclass of: thylakoid
subclass of: organelle subcompartment
subclass of: Restriction
  on property: part of
  some values from: plastid
definition: Any thylakoid within a plastid.
has_obo_namespace: cellular_component
id: GO:0031976

Axiom
annotated source: plastid thylakoid
annotated property: definition
annotated target: Any thylakoid within a plastid.
database_cross_reference: GOC:pz

nuclear lumen
type: Class
subclass of: GO_0070013
subclass of: Restriction
  on property: part of
  some values from: nucleus
definition: The volume enclosed by the nuclear inner membrane.
has_obo_namespace: cellular_component
id: GO:0031981

Axiom
annotated source: nuclear lumen
annotated property: definition
annotated target: The volume enclosed by the nuclear inner membrane.
database_cross_reference: GOC:mah
database_cross_reference: GOC:pz

vesicle
type: Class
subclass of: membrane-bounded organelle
definition: Any small, fluid-filled, spherical organelle enclosed by membrane.
has_alternative_id: GO:0031988
database_cross_reference: NIF_Subcellular:sao221389602
database_cross_reference: Wikipedia:Vesicle_(biology)
has_obo_namespace: cellular_component
has_related_synonym: membrane-bounded vesicle
has_related_synonym: membrane-enclosed vesicle
id: GO:0031982
in_subset: goslim pir

Axiom
annotated source: vesicle
annotated property: definition
annotated target: Any small, fluid-filled, spherical organelle enclosed by membrane.
database_cross_reference: GOC:mah
database_cross_reference: GOC:pz
database_cross_reference: GOC:vesicles

organelle subcompartment
type: Class
subclass of: GO_0110165
subclass of: Restriction
  on property: part of
  some values from: membrane-bounded organelle
subclass of: Restriction
  on property: part of
  some values from: intracellular organelle
definition: A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle.
has_exact_synonym: suborganelle compartment
has_obo_namespace: cellular_component
id: GO:0031984
comment: Note that this term refers to membrane-bounded compartments that are not considered organelles in their own right, but form parts of larger organelles.

Axiom
annotated source: organelle subcompartment
annotated property: definition
annotated target: A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle.
database_cross_reference: GOC:mah
database_cross_reference: GOC:pz

locomotion involved in locomotory behavior
type: Class
equivalent class: Class
  intersection of: locomotion
  intersection of: Restriction
    on property: part of
    some values from: locomotory behavior
subclass of: locomotion
subclass of: Restriction
  on property: part of
  some values from: locomotory behavior
definition: Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.
has_exact_synonym: locomotion during locomotory behaviour
has_obo_namespace: biological_process
id: GO:0031987

Axiom
annotated source: locomotion involved in locomotory behavior
annotated property: definition
annotated target: Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.
database_cross_reference: GOC:mah

mitochondrial DNA metabolic process
type: Class
equivalent class: Class
  intersection of: DNA metabolic process
  intersection of: Restriction
    on property: occurs in
    some values from: mitochondrion
subclass of: DNA metabolic process
subclass of: Restriction
  on property: part of
  some values from: mitochondrial genome maintenance
subclass of: Restriction
  on property: occurs in
  some values from: mitochondrion
definition: The chemical reactions and pathways involving mitochondrial DNA.
has_exact_synonym: mitochondrial DNA metabolism
has_exact_synonym: mtDNA metabolic process
has_exact_synonym: mtDNA metabolism
has_obo_namespace: biological_process
id: GO:0032042

Axiom
annotated source: mitochondrial DNA metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving mitochondrial DNA.
database_cross_reference: GOC:mah

bleb assembly
type: Class
subclass of: GO_0120031
definition: The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.
has_broad_synonym: blebbing
has_broad_synonym: membrane blebbing
has_exact_synonym: cell blebbing
has_exact_synonym: plasma membrane bleb assembly
has_exact_synonym: plasma membrane blebbing
has_obo_namespace: biological_process
id: GO:0032060

Axiom
annotated source: bleb assembly
annotated property: definition
annotated target: The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.
database_cross_reference: GOC:mah
database_cross_reference: GOC:mtg_apoptosis
database_cross_reference: PMID:12083798
database_cross_reference: PMID:16624291
database_cross_reference: Wikipedia:Bleb_(cell_biology)

Axiom
annotated source: bleb assembly
annotated property: has_broad_synonym
annotated target: blebbing
database_cross_reference: GOC:pr

Axiom
annotated source: bleb assembly
annotated property: has_broad_synonym
annotated target: membrane blebbing
database_cross_reference: GOC:pr

Axiom
annotated source: bleb assembly
annotated property: has_exact_synonym
annotated target: plasma membrane bleb assembly
database_cross_reference: GOC:pr

Axiom
annotated source: bleb assembly
annotated property: has_exact_synonym
annotated target: plasma membrane blebbing
database_cross_reference: GOC:pr

negative regulation of protein binding
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: protein binding
subclass of: regulation of protein binding
subclass of: GO_0051100
subclass of: Restriction
  on property: negatively regulates
  some values from: protein binding
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
has_exact_synonym: down regulation of protein binding
has_exact_synonym: down-regulation of protein binding
has_exact_synonym: downregulation of protein binding
has_narrow_synonym: inhibition of protein binding
has_obo_namespace: biological_process
id: GO:0032091

Axiom
annotated source: negative regulation of protein binding
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
database_cross_reference: GOC:mah

positive regulation of protein binding
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: protein binding
subclass of: regulation of protein binding
subclass of: GO_0051099
subclass of: Restriction
  on property: positively regulates
  some values from: protein binding
definition: Any process that activates or increases the frequency, rate or extent of protein binding.
has_exact_synonym: up regulation of protein binding
has_exact_synonym: up-regulation of protein binding
has_exact_synonym: upregulation of protein binding
has_narrow_synonym: activation of protein binding
has_narrow_synonym: stimulation of protein binding
has_obo_namespace: biological_process
id: GO:0032092

Axiom
annotated source: positive regulation of protein binding
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of protein binding.
database_cross_reference: GOC:mah

regulation of response to external stimulus
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: response to external stimulus
subclass of: regulation of response to stimulus
subclass of: Restriction
  on property: regulates
  some values from: response to external stimulus
definition: Any process that modulates the frequency, rate or extent of a response to an external stimulus.
has_obo_namespace: biological_process
id: GO:0032101
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: regulation of response to external stimulus
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of a response to an external stimulus.
database_cross_reference: GOC:mah

negative regulation of response to external stimulus
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: response to external stimulus
subclass of: regulation of response to external stimulus
subclass of: negative regulation of response to stimulus
subclass of: Restriction
  on property: negatively regulates
  some values from: response to external stimulus
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus.
has_exact_synonym: down regulation of response to external stimulus
has_exact_synonym: down-regulation of response to external stimulus
has_exact_synonym: downregulation of response to external stimulus
has_narrow_synonym: inhibition of response to external stimulus
has_obo_namespace: biological_process
id: GO:0032102
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: negative regulation of response to external stimulus
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus.
database_cross_reference: GOC:mah

positive regulation of response to external stimulus
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: response to external stimulus
subclass of: regulation of response to external stimulus
subclass of: positive regulation of response to stimulus
subclass of: Restriction
  on property: positively regulates
  some values from: response to external stimulus
definition: Any process that activates, maintains or increases the rate of a response to an external stimulus.
has_exact_synonym: up regulation of response to external stimulus
has_exact_synonym: up-regulation of response to external stimulus
has_exact_synonym: upregulation of response to external stimulus
has_narrow_synonym: activation of response to external stimulus
has_narrow_synonym: stimulation of response to external stimulus
has_obo_namespace: biological_process
id: GO:0032103
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: positive regulation of response to external stimulus
annotated property: definition
annotated target: Any process that activates, maintains or increases the rate of a response to an external stimulus.
database_cross_reference: GOC:mah

regulation of response to extracellular stimulus
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: response to extracellular stimulus
subclass of: regulation of response to external stimulus
subclass of: Restriction
  on property: regulates
  some values from: response to extracellular stimulus
definition: Any process that modulates the frequency, rate or extent of a response to an extracellular stimulus.
has_obo_namespace: biological_process
id: GO:0032104

Axiom
annotated source: regulation of response to extracellular stimulus
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of a response to an extracellular stimulus.
database_cross_reference: GOC:mah

negative regulation of response to extracellular stimulus
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: response to extracellular stimulus
subclass of: negative regulation of response to external stimulus
subclass of: regulation of response to extracellular stimulus
subclass of: Restriction
  on property: negatively regulates
  some values from: response to extracellular stimulus
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an extracellular stimulus.
has_exact_synonym: down regulation of response to extracellular stimulus
has_exact_synonym: down-regulation of response to extracellular stimulus
has_exact_synonym: downregulation of response to extracellular stimulus
has_narrow_synonym: inhibition of response to extracellular stimulus
has_obo_namespace: biological_process
id: GO:0032105

Axiom
annotated source: negative regulation of response to extracellular stimulus
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an extracellular stimulus.
database_cross_reference: GOC:mah

positive regulation of response to extracellular stimulus
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: response to extracellular stimulus
subclass of: positive regulation of response to external stimulus
subclass of: regulation of response to extracellular stimulus
subclass of: Restriction
  on property: positively regulates
  some values from: response to extracellular stimulus
definition: Any process that activates, maintains or increases the rate of a response to an extracellular stimulus.
has_exact_synonym: up regulation of response to extracellular stimulus
has_exact_synonym: up-regulation of response to extracellular stimulus
has_exact_synonym: upregulation of response to extracellular stimulus
has_narrow_synonym: activation of response to extracellular stimulus
has_narrow_synonym: stimulation of response to extracellular stimulus
has_obo_namespace: biological_process
id: GO:0032106

Axiom
annotated source: positive regulation of response to extracellular stimulus
annotated property: definition
annotated target: Any process that activates, maintains or increases the rate of a response to an extracellular stimulus.
database_cross_reference: GOC:mah

regulation of response to nutrient levels
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: response to nutrient levels
subclass of: regulation of response to extracellular stimulus
subclass of: Restriction
  on property: regulates
  some values from: response to nutrient levels
definition: Any process that modulates the frequency, rate or extent of a response to nutrient levels.
has_obo_namespace: biological_process
id: GO:0032107

Axiom
annotated source: regulation of response to nutrient levels
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of a response to nutrient levels.
database_cross_reference: GOC:mah

negative regulation of response to nutrient levels
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: response to nutrient levels
subclass of: negative regulation of response to extracellular stimulus
subclass of: regulation of response to nutrient levels
subclass of: Restriction
  on property: negatively regulates
  some values from: response to nutrient levels
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of a response to nutrient levels.
has_exact_synonym: down regulation of response to nutrient levels
has_exact_synonym: down-regulation of response to nutrient levels
has_exact_synonym: downregulation of response to nutrient levels
has_narrow_synonym: inhibition of response to nutrient levels
has_obo_namespace: biological_process
id: GO:0032108

Axiom
annotated source: negative regulation of response to nutrient levels
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of a response to nutrient levels.
database_cross_reference: GOC:mah

positive regulation of response to nutrient levels
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: response to nutrient levels
subclass of: positive regulation of response to extracellular stimulus
subclass of: regulation of response to nutrient levels
subclass of: Restriction
  on property: positively regulates
  some values from: response to nutrient levels
definition: Any process that activates or increases the frequency, rate or extent of a response to nutrient levels.
has_exact_synonym: up regulation of response to nutrient levels
has_exact_synonym: up-regulation of response to nutrient levels
has_exact_synonym: upregulation of response to nutrient levels
has_narrow_synonym: activation of response to nutrient levels
has_narrow_synonym: stimulation of response to nutrient levels
has_obo_namespace: biological_process
id: GO:0032109

Axiom
annotated source: positive regulation of response to nutrient levels
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of a response to nutrient levels.
database_cross_reference: GOC:mah

methylation
type: Class
subclass of: metabolic process
definition: The process in which a methyl group is covalently attached to a molecule.
database_cross_reference: Wikipedia:Methylation
has_obo_namespace: biological_process
id: GO:0032259
in_subset: goslim chembl

Axiom
annotated source: methylation
annotated property: definition
annotated target: The process in which a methyl group is covalently attached to a molecule.
database_cross_reference: GOC:mah

regulation of cellular protein metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cellular protein metabolic process
subclass of: regulation of cellular metabolic process
subclass of: GO_0051246
subclass of: Restriction
  on property: regulates
  some values from: cellular protein metabolic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
has_exact_synonym: regulation of cellular protein metabolism
has_obo_namespace: biological_process
id: GO:0032268

Axiom
annotated source: regulation of cellular protein metabolic process
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
database_cross_reference: GOC:mah

negative regulation of cellular protein metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cellular protein metabolic process
subclass of: negative regulation of cellular metabolic process
subclass of: regulation of cellular protein metabolic process
subclass of: GO_0051248
subclass of: Restriction
  on property: negatively regulates
  some values from: cellular protein metabolic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
has_exact_synonym: down regulation of cellular protein metabolic process
has_exact_synonym: down-regulation of cellular protein metabolic process
has_exact_synonym: downregulation of cellular protein metabolic process
has_exact_synonym: negative regulation of cellular protein metabolism
has_narrow_synonym: inhibition of cellular protein metabolic process
has_obo_namespace: biological_process
id: GO:0032269

Axiom
annotated source: negative regulation of cellular protein metabolic process
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
database_cross_reference: GOC:mah

positive regulation of cellular protein metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: cellular protein metabolic process
subclass of: positive regulation of cellular metabolic process
subclass of: regulation of cellular protein metabolic process
subclass of: GO_0051247
subclass of: Restriction
  on property: positively regulates
  some values from: cellular protein metabolic process
definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
has_exact_synonym: positive regulation of cellular protein metabolism
has_exact_synonym: up regulation of cellular protein metabolic process
has_exact_synonym: up-regulation of cellular protein metabolic process
has_exact_synonym: upregulation of cellular protein metabolic process
has_narrow_synonym: activation of cellular protein metabolic process
has_narrow_synonym: stimulation of cellular protein metabolic process
has_obo_namespace: biological_process
id: GO:0032270

Axiom
annotated source: positive regulation of cellular protein metabolic process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
database_cross_reference: GOC:mah

asymmetric synapse
type: Class
equivalent class: Class
  intersection of: GO_0098984
  intersection of: Restriction
    on property: has part
    some values from: postsynaptic density
subclass of: GO_0098984
subclass of: Restriction
  on property: has part
  some values from: postsynaptic density
definition: A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density. Most or all synapses of this type are excitatory.
has_exact_synonym: Gray's type I synapse
has_obo_namespace: cellular_component
id: GO:0032279

Axiom
annotated source: asymmetric synapse
annotated property: definition
annotated target: A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density. Most or all synapses of this type are excitatory.
database_cross_reference: GOC:dgh
database_cross_reference: GOC:ef

regulation of intracellular transport
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: intracellular transport
subclass of: GO_0051049
subclass of: GO_0060341
subclass of: Restriction
  on property: regulates
  some values from: intracellular transport
definition: Any process that modulates the frequency, rate or extent of the directed movement of substances within cells.
has_obo_namespace: biological_process
id: GO:0032386

Axiom
annotated source: regulation of intracellular transport
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the directed movement of substances within cells.
database_cross_reference: GOC:mah

negative regulation of intracellular transport
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: intracellular transport
subclass of: regulation of intracellular transport
subclass of: negative regulation of cellular process
subclass of: GO_0051051
subclass of: Restriction
  on property: negatively regulates
  some values from: intracellular transport
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells.
has_exact_synonym: down regulation of intracellular transport
has_exact_synonym: down-regulation of intracellular transport
has_exact_synonym: downregulation of intracellular transport
has_narrow_synonym: inhibition of intracellular transport
has_obo_namespace: biological_process
id: GO:0032387

Axiom
annotated source: negative regulation of intracellular transport
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells.
database_cross_reference: GOC:mah

positive regulation of intracellular transport
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: intracellular transport
subclass of: regulation of intracellular transport
subclass of: positive regulation of cellular process
subclass of: GO_0051050
subclass of: Restriction
  on property: positively regulates
  some values from: intracellular transport
definition: Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells.
has_exact_synonym: up regulation of intracellular transport
has_exact_synonym: up-regulation of intracellular transport
has_exact_synonym: upregulation of intracellular transport
has_narrow_synonym: activation of intracellular transport
has_narrow_synonym: stimulation of intracellular transport
has_obo_namespace: biological_process
id: GO:0032388

Axiom
annotated source: positive regulation of intracellular transport
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells.
database_cross_reference: GOC:mah

regulation of transporter activity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: transporter activity
subclass of: GO_0065009
subclass of: Restriction
  on property: regulates
  some values from: transporter activity
definition: Any process that modulates the activity of a transporter.
has_obo_namespace: biological_process
id: GO:0032409

Axiom
annotated source: regulation of transporter activity
annotated property: definition
annotated target: Any process that modulates the activity of a transporter.
database_cross_reference: GOC:mah

negative regulation of transporter activity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: transporter activity
subclass of: regulation of transporter activity
subclass of: negative regulation of molecular function
subclass of: GO_0051051
subclass of: Restriction
  on property: negatively regulates
  some values from: transporter activity
definition: Any process that stops or reduces the activity of a transporter.
has_exact_synonym: down regulation of transporter activity
has_exact_synonym: down-regulation of transporter activity
has_exact_synonym: downregulation of transporter activity
has_narrow_synonym: inhibition of transporter activity
has_obo_namespace: biological_process
id: GO:0032410

Axiom
annotated source: negative regulation of transporter activity
annotated property: definition
annotated target: Any process that stops or reduces the activity of a transporter.
database_cross_reference: GOC:mah

positive regulation of transporter activity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: transporter activity
subclass of: regulation of transporter activity
subclass of: positive regulation of molecular function
subclass of: GO_0051050
subclass of: Restriction
  on property: positively regulates
  some values from: transporter activity
definition: Any process that activates or increases the activity of a transporter.
has_exact_synonym: up regulation of transporter activity
has_exact_synonym: up-regulation of transporter activity
has_exact_synonym: upregulation of transporter activity
has_narrow_synonym: activation of transporter activity
has_narrow_synonym: stimulation of transporter activity
has_obo_namespace: biological_process
id: GO:0032411

Axiom
annotated source: positive regulation of transporter activity
annotated property: definition
annotated target: Any process that activates or increases the activity of a transporter.
database_cross_reference: GOC:mah

regulation of ion transmembrane transporter activity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: ion transmembrane transporter activity
subclass of: regulation of transmembrane transporter activity
subclass of: regulation of ion transmembrane transport
subclass of: Restriction
  on property: regulates
  some values from: ion transmembrane transporter activity
definition: Any process that modulates the activity of an ion transporter.
has_exact_synonym: regulation of ion transporter activity
has_obo_namespace: biological_process
id: GO:0032412

Axiom
annotated source: regulation of ion transmembrane transporter activity
annotated property: definition
annotated target: Any process that modulates the activity of an ion transporter.
database_cross_reference: GOC:mah
database_cross_reference: GOC:tb

Axiom
annotated source: regulation of ion transmembrane transporter activity
annotated property: has_exact_synonym
annotated target: regulation of ion transporter activity
database_cross_reference: GOC:tb

negative regulation of ion transmembrane transporter activity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: ion transmembrane transporter activity
subclass of: negative regulation of transporter activity
subclass of: regulation of ion transmembrane transporter activity
subclass of: negative regulation of ion transmembrane transport
subclass of: Restriction
  on property: negatively regulates
  some values from: ion transmembrane transporter activity
definition: Any process that stops or reduces the activity of an ion transporter.
has_exact_synonym: down regulation of ion transporter activity
has_exact_synonym: down-regulation of ion transporter activity
has_exact_synonym: downregulation of ion transporter activity
has_exact_synonym: negative regulation of ion transporter activity
has_narrow_synonym: inhibition of ion transporter activity
has_obo_namespace: biological_process
id: GO:0032413

Axiom
annotated source: negative regulation of ion transmembrane transporter activity
annotated property: definition
annotated target: Any process that stops or reduces the activity of an ion transporter.
database_cross_reference: GOC:mah
database_cross_reference: GOC:tb

Axiom
annotated source: negative regulation of ion transmembrane transporter activity
annotated property: has_exact_synonym
annotated target: negative regulation of ion transporter activity
database_cross_reference: GOC:tb

positive regulation of ion transmembrane transporter activity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: ion transmembrane transporter activity
subclass of: positive regulation of transporter activity
subclass of: regulation of ion transmembrane transporter activity
subclass of: positive regulation of ion transmembrane transport
subclass of: Restriction
  on property: positively regulates
  some values from: ion transmembrane transporter activity
definition: Any process that activates or increases the activity of an ion transporter.
has_exact_synonym: positive regulation of ion transporter activity
has_exact_synonym: up regulation of ion transporter activity
has_exact_synonym: up-regulation of ion transporter activity
has_exact_synonym: upregulation of ion transporter activity
has_narrow_synonym: activation of ion transporter activity
has_narrow_synonym: stimulation of ion transporter activity
has_obo_namespace: biological_process
id: GO:0032414

Axiom
annotated source: positive regulation of ion transmembrane transporter activity
annotated property: definition
annotated target: Any process that activates or increases the activity of an ion transporter.
database_cross_reference: GOC:mah
database_cross_reference: GOC:tb

Axiom
annotated source: positive regulation of ion transmembrane transporter activity
annotated property: has_exact_synonym
annotated target: positive regulation of ion transporter activity
database_cross_reference: GOC:tb

Golgi calcium ion homeostasis
type: Class
equivalent class: Class
  intersection of: GO_0055074
  intersection of: Restriction
    on property: occurs in
    some values from: Golgi apparatus
subclass of: cellular calcium ion homeostasis
subclass of: Restriction
  on property: occurs in
  some values from: Golgi apparatus
definition: Any process involved in the maintenance of an internal steady state of calcium ions within the Golgi apparatus of a cell or between the Golgi and its surroundings.
has_exact_synonym: Golgi calcium ion concentration regulation
has_exact_synonym: calcium ion homeostasis in Golgi
has_exact_synonym: regulation of Golgi calcium ion concentration
has_exact_synonym: regulation of calcium ion concentration in Golgi
has_obo_namespace: biological_process
id: GO:0032468

Axiom
annotated source: Golgi calcium ion homeostasis
annotated property: definition
annotated target: Any process involved in the maintenance of an internal steady state of calcium ions within the Golgi apparatus of a cell or between the Golgi and its surroundings.
database_cross_reference: GOC:mah

endoplasmic reticulum calcium ion homeostasis
type: Class
equivalent class: Class
  intersection of: GO_0055074
  intersection of: Restriction
    on property: occurs in
    some values from: endoplasmic reticulum
subclass of: cellular calcium ion homeostasis
subclass of: Restriction
  on property: occurs in
  some values from: endoplasmic reticulum
definition: Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings.
has_exact_synonym: ER calcium ion concentration regulation
has_exact_synonym: ER calcium ion homeostasis
has_exact_synonym: calcium ion homeostasis in ER
has_exact_synonym: calcium ion homeostasis in endoplasmic reticulum
has_exact_synonym: endoplasmic reticulum calcium ion concentration regulation
has_exact_synonym: regulation of ER calcium ion concentration
has_exact_synonym: regulation of calcium ion concentration in ER
has_exact_synonym: regulation of calcium ion concentration in endoplasmic reticulum
has_exact_synonym: regulation of endoplasmic reticulum calcium ion concentration
has_obo_namespace: biological_process
id: GO:0032469

Axiom
annotated source: endoplasmic reticulum calcium ion homeostasis
annotated property: definition
annotated target: Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings.
database_cross_reference: GOC:mah

multicellular organismal process
type: Class
subclass of: biological_process
disjoint with: biological phase
definition: Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
never in taxon: NCBITaxon 4896
never in taxon: NCBITaxon 4932
created by: janelomax
creation date: 2012-09-19T16:07:47Z
has_alternative_id: GO:0044707
has_alternative_id: GO:0050874
has_exact_synonym: organismal physiological process
has_obo_namespace: biological_process
has_related_synonym: single-multicellular organism process
id: GO:0032501
in_subset: goslim pir

Axiom
annotated source: multicellular organismal process
annotated property: definition
annotated target: Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
database_cross_reference: GOC:curators
database_cross_reference: GOC:dph
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:tb

developmental process
type: Class
subclass of: biological_process
disjoint with: biological phase
definition: A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
created by: janelomax
creation date: 2012-12-19T12:21:31Z
has_alternative_id: GO:0044767
has_narrow_synonym: development
has_obo_namespace: biological_process
has_related_synonym: single-organism developmental process
id: GO:0032502
in_subset: goslim agr
in_subset: goslim aspergillus
in_subset: goslim flybase ribbon
in_subset: goslim pir

Axiom
annotated source: developmental process
annotated property: definition
annotated target: A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
database_cross_reference: GOC:isa_complete

multicellular organism reproduction
type: Class
subclass of: reproduction
subclass of: multicellular organismal process
definition: The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.
has_obo_namespace: biological_process
id: GO:0032504

Axiom
annotated source: multicellular organism reproduction
annotated property: definition
annotated target: The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:jid

protein transport within lipid bilayer
type: Class
equivalent class: Class
  intersection of: protein transport
  intersection of: Restriction
    on property: occurs in
    some values from: membrane
subclass of: intracellular protein transport
subclass of: GO_0051668
subclass of: GO_0061024
definition: The directed movement of a protein from one location to another within a lipid bilayer.
has_exact_synonym: protein translocation within membrane
has_narrow_synonym: receptor translocation within membrane
has_narrow_synonym: receptor transport within lipid bilayer
has_obo_namespace: biological_process
id: GO:0032594

Axiom
annotated source: protein transport within lipid bilayer
annotated property: definition
annotated target: The directed movement of a protein from one location to another within a lipid bilayer.
database_cross_reference: GOC:mah

RNA biosynthetic process
type: Class
subclass of: macromolecule biosynthetic process
subclass of: RNA metabolic process
subclass of: nucleobase-containing compound biosynthetic process
definition: The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication.
has_exact_synonym: RNA anabolism
has_exact_synonym: RNA biosynthesis
has_exact_synonym: RNA formation
has_exact_synonym: RNA synthesis
has_obo_namespace: biological_process
id: GO:0032774
comment: Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study.

Axiom
annotated source: RNA biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication.
database_cross_reference: GOC:mah
database_cross_reference: GOC:txnOH

monocarboxylic acid metabolic process
type: Class
subclass of: carboxylic acid metabolic process
definition: The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).
has_exact_synonym: monocarboxylate metabolic process
has_exact_synonym: monocarboxylic acid metabolism
has_obo_namespace: biological_process
id: GO:0032787
in_subset: goslim yeast

Axiom
annotated source: monocarboxylic acid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).
database_cross_reference: GOC:vk

regulation of natural killer cell activation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: natural killer cell activation
subclass of: GO_0051249
subclass of: Restriction
  on property: regulates
  some values from: natural killer cell activation
definition: Any process that modulates the frequency, rate or extent of natural killer cell activation.
has_exact_synonym: regulation of NK cell activation
has_obo_namespace: biological_process
id: GO:0032814

Axiom
annotated source: regulation of natural killer cell activation
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of natural killer cell activation.
database_cross_reference: GOC:mah

negative regulation of natural killer cell activation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: natural killer cell activation
subclass of: regulation of natural killer cell activation
subclass of: GO_0051250
subclass of: Restriction
  on property: negatively regulates
  some values from: natural killer cell activation
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation.
has_exact_synonym: down regulation of natural killer cell activation
has_exact_synonym: down-regulation of natural killer cell activation
has_exact_synonym: downregulation of natural killer cell activation
has_exact_synonym: negative regulation of NK cell activation
has_narrow_synonym: inhibition of natural killer cell activation
has_obo_namespace: biological_process
id: GO:0032815

Axiom
annotated source: negative regulation of natural killer cell activation
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation.
database_cross_reference: GOC:mah

positive regulation of natural killer cell activation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: natural killer cell activation
subclass of: regulation of natural killer cell activation
subclass of: GO_0051251
subclass of: Restriction
  on property: positively regulates
  some values from: natural killer cell activation
definition: Any process that activates or increases the frequency, rate or extent of natural killer cell activation.
has_exact_synonym: positive regulation of NK cell activation
has_exact_synonym: up regulation of natural killer cell activation
has_exact_synonym: up-regulation of natural killer cell activation
has_exact_synonym: upregulation of natural killer cell activation
has_narrow_synonym: activation of natural killer cell activation
has_narrow_synonym: stimulation of natural killer cell activation
has_obo_namespace: biological_process
id: GO:0032816

Axiom
annotated source: positive regulation of natural killer cell activation
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of natural killer cell activation.
database_cross_reference: GOC:mah

plasma membrane bounded cell projection cytoplasm
type: Class
equivalent class: Class
  intersection of: cytoplasm
  intersection of: Restriction
    on property: part of
    some values from: GO_0120025
subclass of: GO_0099568
subclass of: Restriction
  on property: part of
  some values from: GO_0120025
definition: All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection.
has_obo_namespace: cellular_component
id: GO:0032838

Axiom
annotated source: plasma membrane bounded cell projection cytoplasm
annotated property: definition
annotated target: All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection.
database_cross_reference: GOC:krc
database_cross_reference: GOC:mah

cellular response to hormone stimulus
type: Class
subclass of: response to hormone
subclass of: GO_0071310
subclass of: GO_0071495
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
has_obo_namespace: biological_process
id: GO:0032870

Axiom
annotated source: cellular response to hormone stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
database_cross_reference: GOC:mah

regulation of localization
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: GO_0051179
subclass of: GO_0050789
subclass of: Restriction
  on property: regulates
  some values from: GO_0051179
definition: Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.
has_exact_synonym: regulation of localisation
has_obo_namespace: biological_process
id: GO:0032879

Axiom
annotated source: regulation of localization
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.
database_cross_reference: GOC:mah

Axiom
annotated source: regulation of localization
annotated property: has_exact_synonym
annotated target: regulation of localisation
database_cross_reference: GOC:mah

regulation of protein localization
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: protein localization
subclass of: regulation of localization
subclass of: Restriction
  on property: regulates
  some values from: protein localization
definition: Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
has_exact_synonym: regulation of protein localisation
has_obo_namespace: biological_process
id: GO:0032880
in_subset: goslim chembl

Axiom
annotated source: regulation of protein localization
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
database_cross_reference: GOC:dph
database_cross_reference: GOC:mah
database_cross_reference: GOC:tb

Axiom
annotated source: regulation of protein localization
annotated property: has_exact_synonym
annotated target: regulation of protein localisation
database_cross_reference: GOC:mah

regulation of microtubule-based process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: microtubule-based process
subclass of: GO_0050794
subclass of: Restriction
  on property: regulates
  some values from: microtubule-based process
definition: Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton.
has_obo_namespace: biological_process
id: GO:0032886

Axiom
annotated source: regulation of microtubule-based process
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton.
database_cross_reference: GOC:mah

regulation of spindle elongation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: GO_0051231
subclass of: GO_0051983
subclass of: GO_0090224
subclass of: Restriction
  on property: regulates
  some values from: GO_0051231
definition: Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the spindle.
has_obo_namespace: biological_process
id: GO:0032887

Axiom
annotated source: regulation of spindle elongation
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the spindle.
database_cross_reference: GOC:mah

regulation of mitotic spindle elongation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: mitotic spindle elongation
subclass of: regulation of spindle elongation
subclass of: regulation of mitotic sister chromatid segregation
subclass of: GO_0060236
subclass of: Restriction
  on property: regulates
  some values from: mitotic spindle elongation
definition: Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle.
has_obo_namespace: biological_process
id: GO:0032888

Axiom
annotated source: regulation of mitotic spindle elongation
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle.
database_cross_reference: GOC:mah

regulation of organic acid transport
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: organic acid transport
subclass of: GO_0051049
subclass of: Restriction
  on property: regulates
  some values from: organic acid transport
definition: Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has_obo_namespace: biological_process
id: GO:0032890

Axiom
annotated source: regulation of organic acid transport
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
database_cross_reference: GOC:mah

negative regulation of organic acid transport
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: organic acid transport
subclass of: regulation of organic acid transport
subclass of: GO_0051051
subclass of: Restriction
  on property: negatively regulates
  some values from: organic acid transport
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has_exact_synonym: down regulation of organic acid transport
has_exact_synonym: down-regulation of organic acid transport
has_exact_synonym: downregulation of organic acid transport
has_narrow_synonym: inhibition of organic acid transport
has_obo_namespace: biological_process
id: GO:0032891

Axiom
annotated source: negative regulation of organic acid transport
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
database_cross_reference: GOC:mah

positive regulation of organic acid transport
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: organic acid transport
subclass of: regulation of organic acid transport
subclass of: GO_0051050
subclass of: Restriction
  on property: positively regulates
  some values from: organic acid transport
definition: Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has_exact_synonym: up regulation of organic acid transport
has_exact_synonym: up-regulation of organic acid transport
has_exact_synonym: upregulation of organic acid transport
has_narrow_synonym: activation of organic acid transport
has_narrow_synonym: stimulation of organic acid transport
has_obo_namespace: biological_process
id: GO:0032892

Axiom
annotated source: positive regulation of organic acid transport
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
database_cross_reference: GOC:mah

secretion by cell
type: Class
subclass of: secretion
subclass of: GO_0140352
definition: The controlled release of a substance by a cell.
database_cross_reference: Wikipedia:Secretion
has_exact_synonym: cellular secretion
has_obo_namespace: biological_process
id: GO:0032940

Axiom
annotated source: secretion by cell
annotated property: definition
annotated target: The controlled release of a substance by a cell.
database_cross_reference: GOC:mah

cellular component morphogenesis
type: Class
subclass of: anatomical structure morphogenesis
subclass of: cellular component organization
subclass of: cellular developmental process
definition: The process in which cellular structures, including whole cells or cell parts, are generated and organized.
has_exact_synonym: cellular structure morphogenesis
has_obo_namespace: biological_process
id: GO:0032989
in_subset: goslim pir

Axiom
annotated source: cellular component morphogenesis
annotated property: definition
annotated target: The process in which cellular structures, including whole cells or cell parts, are generated and organized.
database_cross_reference: GOC:dph
database_cross_reference: GOC:mah
database_cross_reference: GOC:tb

Axiom
annotated source: cellular component morphogenesis
annotated property: has_exact_synonym
annotated target: cellular structure morphogenesis
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

protein-containing complex
type: Class
subclass of: cellular_component
definition: A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
has_alternative_id: GO:0043234
has_exact_synonym: macromolecular complex
has_exact_synonym: macromolecule complex
has_exact_synonym: protein containing complex
has_narrow_synonym: protein complex
has_narrow_synonym: protein-protein complex
has_obo_namespace: cellular_component
id: GO:0032991
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim pir
comment: A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole.

Axiom
annotated source: protein-containing complex
annotated property: definition
annotated target: A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
database_cross_reference: GOC:dos
database_cross_reference: GOC:mah

tetrapyrrole metabolic process
type: Class
subclass of: cellular aromatic compound metabolic process
subclass of: heterocycle metabolic process
subclass of: GO_1901360
subclass of: GO_1901564
definition: The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.
has_exact_synonym: tetrapyrrole metabolism
has_obo_namespace: biological_process
id: GO:0033013

Axiom
annotated source: tetrapyrrole metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.
database_cross_reference: GOC:mah

macromolecule localization
type: Class
subclass of: GO_0051179
definition: Any process in which a macromolecule is transported to, or maintained in, a specific location.
has_exact_synonym: macromolecule localisation
has_obo_namespace: biological_process
id: GO:0033036
in_subset: goslim flybase ribbon

Axiom
annotated source: macromolecule localization
annotated property: definition
annotated target: Any process in which a macromolecule is transported to, or maintained in, a specific location.
database_cross_reference: GOC:mah

Axiom
annotated source: macromolecule localization
annotated property: has_exact_synonym
annotated target: macromolecule localisation
database_cross_reference: GOC:mah

regulation of organelle organization
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: organelle organization
subclass of: GO_0051128
subclass of: Restriction
  on property: regulates
  some values from: organelle organization
definition: Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.
has_exact_synonym: regulation of organelle organisation
has_obo_namespace: biological_process
has_related_synonym: regulation of organelle organization and biogenesis
id: GO:0033043
in_subset: goslim yeast

Axiom
annotated source: regulation of organelle organization
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.
database_cross_reference: GOC:mah

Axiom
annotated source: regulation of organelle organization
annotated property: has_exact_synonym
annotated target: regulation of organelle organisation
database_cross_reference: GOC:mah

Axiom
annotated source: regulation of organelle organization
annotated property: has_related_synonym
annotated target: regulation of organelle organization and biogenesis
database_cross_reference: GOC:mah

regulation of chromosome organization
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: GO_0051276
subclass of: regulation of organelle organization
subclass of: Restriction
  on property: regulates
  some values from: GO_0051276
definition: Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome.
has_exact_synonym: regulation of chromosome organisation
has_obo_namespace: biological_process
has_related_synonym: regulation of chromosome organization and biogenesis
id: GO:0033044

Axiom
annotated source: regulation of chromosome organization
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome.
database_cross_reference: GOC:mah

Axiom
annotated source: regulation of chromosome organization
annotated property: has_exact_synonym
annotated target: regulation of chromosome organisation
database_cross_reference: GOC:mah

Axiom
annotated source: regulation of chromosome organization
annotated property: has_related_synonym
annotated target: regulation of chromosome organization and biogenesis
database_cross_reference: GOC:mah

regulation of sister chromatid segregation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: sister chromatid segregation
subclass of: regulation of cell cycle process
subclass of: regulation of chromosome organization
subclass of: GO_0051983
subclass of: Restriction
  on property: regulates
  some values from: sister chromatid segregation
definition: Any process that modulates the frequency, rate or extent of sister chromatid segregation.
has_obo_namespace: biological_process
id: GO:0033045

Axiom
annotated source: regulation of sister chromatid segregation
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of sister chromatid segregation.
database_cross_reference: GOC:mah

negative regulation of sister chromatid segregation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: sister chromatid segregation
subclass of: negative regulation of cell cycle process
subclass of: regulation of sister chromatid segregation
subclass of: GO_0051985
subclass of: GO_2001251
subclass of: Restriction
  on property: negatively regulates
  some values from: sister chromatid segregation
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation.
has_obo_namespace: biological_process
id: GO:0033046

Axiom
annotated source: negative regulation of sister chromatid segregation
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation.
database_cross_reference: GOC:mah

regulation of mitotic sister chromatid segregation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: mitotic sister chromatid segregation
subclass of: regulation of mitotic nuclear division
subclass of: regulation of sister chromatid segregation
subclass of: Restriction
  on property: regulates
  some values from: mitotic sister chromatid segregation
definition: Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis.
has_obo_namespace: biological_process
id: GO:0033047

Axiom
annotated source: regulation of mitotic sister chromatid segregation
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis.
database_cross_reference: GOC:mah

negative regulation of mitotic sister chromatid segregation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: mitotic sister chromatid segregation
subclass of: negative regulation of sister chromatid segregation
subclass of: regulation of mitotic sister chromatid segregation
subclass of: negative regulation of mitotic nuclear division
subclass of: Restriction
  on property: negatively regulates
  some values from: mitotic sister chromatid segregation
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis.
has_obo_namespace: biological_process
id: GO:0033048

Axiom
annotated source: negative regulation of mitotic sister chromatid segregation
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis.
database_cross_reference: GOC:mah

progesterone receptor binding
type: Class
subclass of: nuclear receptor binding
subclass of: steroid hormone receptor binding
definition: Interacting selectively and non-covalently with a progesterone receptor.
has_obo_namespace: molecular_function
id: GO:0033142

Axiom
annotated source: progesterone receptor binding
annotated property: definition
annotated target: Interacting selectively and non-covalently with a progesterone receptor.
database_cross_reference: GOC:mah

regulation of intracellular protein transport
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: intracellular protein transport
subclass of: regulation of intracellular transport
subclass of: GO_0051223
subclass of: GO_1903827
subclass of: Restriction
  on property: regulates
  some values from: intracellular protein transport
definition: Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells.
has_obo_namespace: biological_process
id: GO:0033157

Axiom
annotated source: regulation of intracellular protein transport
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells.
database_cross_reference: GOC:mah

response to vitamin
type: Class
subclass of: response to nutrient
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus.
has_obo_namespace: biological_process
id: GO:0033273

Axiom
annotated source: response to vitamin
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus.
database_cross_reference: GOC:sl

secretory granule organization
type: Class
subclass of: vesicle organization
subclass of: Restriction
  on property: part of
  some values from: endomembrane system organization
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion.
has_exact_synonym: secretory granule organisation
has_obo_namespace: biological_process
has_related_synonym: secretory granule organization and biogenesis
id: GO:0033363

Axiom
annotated source: secretory granule organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion.
database_cross_reference: GOC:mah

Axiom
annotated source: secretory granule organization
annotated property: has_exact_synonym
annotated target: secretory granule organisation
database_cross_reference: GOC:mah

Axiom
annotated source: secretory granule organization
annotated property: has_related_synonym
annotated target: secretory granule organization and biogenesis
database_cross_reference: GOC:mah

protein localization to organelle
type: Class
subclass of: cellular protein localization
definition: A process in which a protein is transported to, or maintained in, a location within an organelle.
has_exact_synonym: protein localisation to organelle
has_exact_synonym: protein localization in organelle
has_obo_namespace: biological_process
id: GO:0033365

Axiom
annotated source: protein localization to organelle
annotated property: definition
annotated target: A process in which a protein is transported to, or maintained in, a location within an organelle.
database_cross_reference: GOC:mah

Axiom
annotated source: protein localization to organelle
annotated property: has_exact_synonym
annotated target: protein localisation to organelle
database_cross_reference: GOC:mah

Axiom
annotated source: protein localization to organelle
annotated property: has_exact_synonym
annotated target: protein localization in organelle
database_cross_reference: GOC:mah

T cell secretory granule organization
type: Class
subclass of: secretory granule organization
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a T cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion.
has_exact_synonym: T cell secretory granule organisation
has_exact_synonym: T lymphocyte secretory granule organization
has_exact_synonym: T-cell secretory granule organization
has_exact_synonym: T-lymphocyte secretory granule organization
has_obo_namespace: biological_process
has_related_synonym: T cell secretory granule organization and biogenesis
has_related_synonym: T-lymphocyte secretory granule maturation
id: GO:0033371

Axiom
annotated source: T cell secretory granule organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a T cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion.
database_cross_reference: GOC:mah

Axiom
annotated source: T cell secretory granule organization
annotated property: has_exact_synonym
annotated target: T cell secretory granule organisation
database_cross_reference: GOC:mah

Axiom
annotated source: T cell secretory granule organization
annotated property: has_related_synonym
annotated target: T cell secretory granule organization and biogenesis
database_cross_reference: GOC:mah

carbohydrate homeostasis
type: Class
subclass of: chemical homeostasis
definition: A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell.
has_obo_namespace: biological_process
id: GO:0033500

Axiom
annotated source: carbohydrate homeostasis
annotated property: definition
annotated target: A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell.
database_cross_reference: GOC:mah

cellular response to stress
type: Class
subclass of: response to stress
subclass of: GO_0051716
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
has_obo_namespace: biological_process
id: GO:0033554
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: cellular response to stress
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
database_cross_reference: GOC:mah

protein glycosylation in cytosol
type: Class
equivalent class: Class
  intersection of: protein glycosylation
  intersection of: Restriction
    on property: occurs in
    some values from: cytosol
subclass of: protein glycosylation
subclass of: Restriction
  on property: occurs in
  some values from: cytosol
definition: The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in the cytosol.
has_exact_synonym: protein amino acid glycosylation in cytosol
has_obo_namespace: biological_process
id: GO:0033576

Axiom
annotated source: protein glycosylation in cytosol
annotated property: definition
annotated target: The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in the cytosol.
database_cross_reference: GOC:mah
database_cross_reference: GOC:pr
database_cross_reference: PMID:12042244

Axiom
annotated source: protein glycosylation in cytosol
annotated property: has_exact_synonym
annotated target: protein amino acid glycosylation in cytosol
database_cross_reference: GOC:bf

protein glycosylation in endoplasmic reticulum
type: Class
equivalent class: Class
  intersection of: protein glycosylation
  intersection of: Restriction
    on property: occurs in
    some values from: endoplasmic reticulum
subclass of: protein glycosylation
subclass of: Restriction
  on property: occurs in
  some values from: endoplasmic reticulum
definition: The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in the endoplasmic reticulum.
has_exact_synonym: protein amino acid glycosylation in ER
has_exact_synonym: protein amino acid glycosylation in endoplasmic reticulum
has_obo_namespace: biological_process
has_related_synonym: core glycosylation
id: GO:0033577

Axiom
annotated source: protein glycosylation in endoplasmic reticulum
annotated property: definition
annotated target: The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in the endoplasmic reticulum.
database_cross_reference: GOC:mah
database_cross_reference: GOC:pr
database_cross_reference: PMID:12042244

Axiom
annotated source: protein glycosylation in endoplasmic reticulum
annotated property: has_exact_synonym
annotated target: protein amino acid glycosylation in endoplasmic reticulum
database_cross_reference: GOC:bf

Axiom
annotated source: protein glycosylation in endoplasmic reticulum
annotated property: has_related_synonym
annotated target: core glycosylation
database_cross_reference: PMID:6345657

protein glycosylation in Golgi
type: Class
equivalent class: Class
  intersection of: protein glycosylation
  intersection of: Restriction
    on property: occurs in
    some values from: Golgi apparatus
subclass of: protein glycosylation
subclass of: Restriction
  on property: occurs in
  some values from: Golgi apparatus
definition: The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus.
has_exact_synonym: protein amino acid glycosylation in Golgi
has_narrow_synonym: terminal glycosylation
has_obo_namespace: biological_process
id: GO:0033578

Axiom
annotated source: protein glycosylation in Golgi
annotated property: definition
annotated target: The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus.
database_cross_reference: GOC:mah
database_cross_reference: GOC:pr
database_cross_reference: PMID:12042244

Axiom
annotated source: protein glycosylation in Golgi
annotated property: has_exact_synonym
annotated target: protein amino acid glycosylation in Golgi
database_cross_reference: GOC:bf

Axiom
annotated source: protein glycosylation in Golgi
annotated property: has_narrow_synonym
annotated target: terminal glycosylation
database_cross_reference: PMID:6345657

modulation by symbiont of host response to abiotic stimulus
type: Class
equivalent class: Class
  intersection of: modulation by symbiont of host process
  intersection of: Restriction
    on property: regulates
    some values from: response to abiotic stimulus
subclass of: modulation by symbiont of host process
subclass of: regulation of response to stimulus
subclass of: Restriction
  on property: regulates
  some values from: response to abiotic stimulus
definition: Any process in which an organism modulates a change in the state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has_obo_namespace: biological_process
id: GO:0033635

Axiom
annotated source: modulation by symbiont of host response to abiotic stimulus
annotated property: definition
annotated target: Any process in which an organism modulates a change in the state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction.
database_cross_reference: GOC:pamgo_curators

modulation by symbiont of host response to temperature stimulus
type: Class
equivalent class: Class
  intersection of: modulation by symbiont of host process
  intersection of: Restriction
    on property: regulates
    some values from: response to temperature stimulus
subclass of: modulation by symbiont of host response to abiotic stimulus
subclass of: Restriction
  on property: regulates
  some values from: response to temperature stimulus
definition: Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has_exact_synonym: modulation by symbiont of host response to thermal stimulus
has_obo_namespace: biological_process
id: GO:0033636

Axiom
annotated source: modulation by symbiont of host response to temperature stimulus
annotated property: definition
annotated target: Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction.
database_cross_reference: GOC:pamgo_curators

modulation by symbiont of host response to osmotic stress
type: Class
equivalent class: Class
  intersection of: modulation by symbiont of host process
  intersection of: Restriction
    on property: regulates
    some values from: response to osmotic stress
subclass of: modulation by symbiont of host response to abiotic stimulus
subclass of: regulation of response to osmotic stress
definition: Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has_obo_namespace: biological_process
id: GO:0033640

Axiom
annotated source: modulation by symbiont of host response to osmotic stress
annotated property: definition
annotated target: Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.
database_cross_reference: GOC:pamgo_curators

modulation by symbiont of host response to pH
type: Class
equivalent class: Class
  intersection of: modulation by symbiont of host process
  intersection of: Restriction
    on property: regulates
    some values from: response to pH
subclass of: modulation by symbiont of host response to abiotic stimulus
subclass of: Restriction
  on property: regulates
  some values from: response to pH
definition: Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has_obo_namespace: biological_process
id: GO:0033641

Axiom
annotated source: modulation by symbiont of host response to pH
annotated property: definition
annotated target: Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction.
database_cross_reference: GOC:pamgo_curators

host cell part
type: Class
equivalent class: Class
  intersection of: host cellular component
  intersection of: Restriction
    on property: part of
    some values from: host cell
subclass of: host cellular component
subclass of: Restriction
  on property: part of
  some values from: host cell
definition: Any constituent part of a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has_obo_namespace: cellular_component
id: GO:0033643
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: host cell part
annotated property: definition
annotated target: Any constituent part of a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.
database_cross_reference: GOC:pamgo_curators

host intracellular part
type: Class
subclass of: host cell part
subclass of: Restriction
  on property: part of
  some values from: host intracellular region
definition: Any constituent part of the living contents of a host cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has_exact_synonym: host cell intracellular part
has_obo_namespace: cellular_component
id: GO:0033646
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: host intracellular part
annotated property: definition
annotated target: Any constituent part of the living contents of a host cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction.
database_cross_reference: GOC:pamgo_curators

host intracellular organelle
type: Class
subclass of: host intracellular part
definition: Organized structure of distinctive morphology and function, occurring within the host cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has_obo_namespace: cellular_component
id: GO:0033647

Axiom
annotated source: host intracellular organelle
annotated property: definition
annotated target: Organized structure of distinctive morphology and function, occurring within the host cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction.
database_cross_reference: GOC:pamgo_curators

host intracellular membrane-bounded organelle
type: Class
subclass of: host intracellular organelle
definition: Organized structure of distinctive morphology and function, as found in host cells, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has_exact_synonym: host intracellular membrane-enclosed organelle
has_obo_namespace: cellular_component
id: GO:0033648

Axiom
annotated source: host intracellular membrane-bounded organelle
annotated property: definition
annotated target: Organized structure of distinctive morphology and function, as found in host cells, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction.
database_cross_reference: GOC:pamgo_curators

negative regulation by symbiont of host apoptotic process
type: Class
equivalent class: Class
  intersection of: modulation by symbiont of host process
  intersection of: Restriction
    on property: negatively regulates
    some values from: apoptotic process
subclass of: negative regulation of apoptotic process
subclass of: GO_0052041
subclass of: GO_0052150
definition: Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has_exact_synonym: down regulation by organism of host apoptotic programmed cell death
has_exact_synonym: down-regulation by organism of host apoptotic programmed cell death
has_exact_synonym: downregulation by organism of host apoptotic programmed cell death
has_narrow_synonym: inhibition by organism of host apoptotic programmed cell death
has_narrow_synonym: negative regulation by symbiont of host apoptosis
has_obo_namespace: biological_process
id: GO:0033668
comment: Note that term is to be used to annotate gene products in the symbiont. To annotate host gene products, consider the biological process term 'negative regulation of apoptosis ; GO:0043066'.

Axiom
annotated source: negative regulation by symbiont of host apoptotic process
annotated property: definition
annotated target: Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction.
database_cross_reference: GOC:pamgo_curators

negative regulation of kinase activity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: kinase activity
subclass of: negative regulation of phosphorylation
subclass of: regulation of kinase activity
subclass of: GO_0051348
subclass of: Restriction
  on property: negatively regulates
  some values from: kinase activity
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
has_exact_synonym: down regulation of kinase activity
has_exact_synonym: down-regulation of kinase activity
has_exact_synonym: downregulation of kinase activity
has_narrow_synonym: inhibition of kinase activity
has_narrow_synonym: kinase inhibitor
has_obo_namespace: biological_process
id: GO:0033673

Axiom
annotated source: negative regulation of kinase activity
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
database_cross_reference: GOC:mah

positive regulation of kinase activity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: kinase activity
subclass of: positive regulation of phosphorylation
subclass of: regulation of kinase activity
subclass of: GO_0051347
subclass of: Restriction
  on property: positively regulates
  some values from: kinase activity
definition: Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
has_exact_synonym: up regulation of kinase activity
has_exact_synonym: up-regulation of kinase activity
has_exact_synonym: upregulation of kinase activity
has_narrow_synonym: kinase activator
has_narrow_synonym: stimulation of kinase activity
has_obo_namespace: biological_process
id: GO:0033674

Axiom
annotated source: positive regulation of kinase activity
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
database_cross_reference: GOC:mah

response to lipid
type: Class
subclass of: response to organic substance
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus.
has_obo_namespace: biological_process
id: GO:0033993

Axiom
annotated source: response to lipid
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus.
database_cross_reference: GOC:sl

response to cytokine
type: Class
subclass of: response to organic substance
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
has_exact_synonym: response to cytokine stimulus
has_obo_namespace: biological_process
id: GO:0034097

Axiom
annotated source: response to cytokine
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
database_cross_reference: GOC:sl

Axiom
annotated source: response to cytokine
annotated property: has_exact_synonym
annotated target: response to cytokine stimulus
database_cross_reference: GOC:dos

erythrocyte homeostasis
type: Class
subclass of: myeloid cell homeostasis
definition: Any process of regulating the production and elimination of erythrocytes within an organism.
has_exact_synonym: RBC homeostasis
has_exact_synonym: red blood cell homeostasis
has_obo_namespace: biological_process
id: GO:0034101

Axiom
annotated source: erythrocyte homeostasis
annotated property: definition
annotated target: Any process of regulating the production and elimination of erythrocytes within an organism.
database_cross_reference: GOC:add
database_cross_reference: PMID:10694114
database_cross_reference: PMID:14754397

Axiom
annotated source: erythrocyte homeostasis
annotated property: has_exact_synonym
annotated target: RBC homeostasis
database_cross_reference: CL:0000232

Axiom
annotated source: erythrocyte homeostasis
annotated property: has_exact_synonym
annotated target: red blood cell homeostasis
database_cross_reference: CL:0000232

homotypic cell-cell adhesion
type: Class
subclass of: GO_0098609
definition: The attachment of a cell to a second cell of the identical type via adhesion molecules.
has_obo_namespace: biological_process
id: GO:0034109
comment: Note that this term is not synonymous with 'homophilic cell adhesion ; GO:0007156'; the process may occur by homophilic or heterophilic mechanisms.

Axiom
annotated source: homotypic cell-cell adhesion
annotated property: definition
annotated target: The attachment of a cell to a second cell of the identical type via adhesion molecules.
database_cross_reference: GOC:add

regulation of homotypic cell-cell adhesion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: homotypic cell-cell adhesion
subclass of: regulation of cell-cell adhesion
subclass of: Restriction
  on property: regulates
  some values from: homotypic cell-cell adhesion
definition: Any process that modulates the frequency, rate, or extent of homotypic cell-cell adhesion.
has_obo_namespace: biological_process
id: GO:0034110

Axiom
annotated source: regulation of homotypic cell-cell adhesion
annotated property: definition
annotated target: Any process that modulates the frequency, rate, or extent of homotypic cell-cell adhesion.
database_cross_reference: GOC:add

negative regulation of homotypic cell-cell adhesion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: homotypic cell-cell adhesion
subclass of: negative regulation of cell-cell adhesion
subclass of: regulation of homotypic cell-cell adhesion
subclass of: Restriction
  on property: negatively regulates
  some values from: homotypic cell-cell adhesion
definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of homotypic cell-cell adhesion.
has_obo_namespace: biological_process
id: GO:0034111

Axiom
annotated source: negative regulation of homotypic cell-cell adhesion
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate, or extent of homotypic cell-cell adhesion.
database_cross_reference: GOC:add

positive regulation of homotypic cell-cell adhesion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: homotypic cell-cell adhesion
subclass of: positive regulation of cell-cell adhesion
subclass of: regulation of homotypic cell-cell adhesion
subclass of: Restriction
  on property: positively regulates
  some values from: homotypic cell-cell adhesion
definition: Any process that activates or increases the frequency, rate, or extent of homotypic cell-cell adhesion.
has_obo_namespace: biological_process
id: GO:0034112

Axiom
annotated source: positive regulation of homotypic cell-cell adhesion
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate, or extent of homotypic cell-cell adhesion.
database_cross_reference: GOC:add

ion transmembrane transport
type: Class
subclass of: ion transport
subclass of: GO_0055085
definition: A process in which an ion is transported across a membrane.
has_alternative_id: GO:0099131
has_exact_synonym: ion membrane transport
has_exact_synonym: transmembrane ion transport
has_narrow_synonym: ATP hydrolysis coupled ion transmembrane transport
has_obo_namespace: biological_process
id: GO:0034220
comment: Note that this term is not intended for use in annotating lateral movement within membranes.

Axiom
annotated source: ion transmembrane transport
annotated property: definition
annotated target: A process in which an ion is transported across a membrane.
database_cross_reference: GOC:mah

Axiom
annotated source: ion transmembrane transport
annotated property: has_exact_synonym
annotated target: transmembrane ion transport
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

regulation of cellular amide metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cellular amide metabolic process
subclass of: regulation of cellular metabolic process
subclass of: GO_0051171
subclass of: Restriction
  on property: regulates
  some values from: cellular amide metabolic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides.
has_exact_synonym: regulation of amide metabolism
has_obo_namespace: biological_process
id: GO:0034248

Axiom
annotated source: regulation of cellular amide metabolic process
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides.
database_cross_reference: GOC:mah

negative regulation of cellular amide metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cellular amide metabolic process
subclass of: negative regulation of cellular metabolic process
subclass of: regulation of cellular amide metabolic process
subclass of: GO_0051172
subclass of: Restriction
  on property: negatively regulates
  some values from: cellular amide metabolic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides.
has_exact_synonym: negative regulation of amide metabolism
has_obo_namespace: biological_process
id: GO:0034249

Axiom
annotated source: negative regulation of cellular amide metabolic process
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides.
database_cross_reference: GOC:mah

positive regulation of cellular amide metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: cellular amide metabolic process
subclass of: positive regulation of cellular metabolic process
subclass of: regulation of cellular amide metabolic process
subclass of: GO_0051173
subclass of: Restriction
  on property: positively regulates
  some values from: cellular amide metabolic process
definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides.
has_exact_synonym: positive regulation of amide metabolism
has_obo_namespace: biological_process
id: GO:0034250

Axiom
annotated source: positive regulation of cellular amide metabolic process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides.
database_cross_reference: GOC:mah

nucleobase-containing small molecule biosynthetic process
type: Class
subclass of: nucleobase-containing compound biosynthetic process
subclass of: small molecule biosynthetic process
subclass of: GO_0055086
definition: The chemical reactions and pathways resulting in the formation of a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide.
has_exact_synonym: nucleobase, nucleoside and nucleotide anabolism
has_exact_synonym: nucleobase, nucleoside and nucleotide biosynthesis
has_exact_synonym: nucleobase, nucleoside and nucleotide formation
has_exact_synonym: nucleobase, nucleoside and nucleotide synthesis
has_obo_namespace: biological_process
id: GO:0034404

Axiom
annotated source: nucleobase-containing small molecule biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide.
database_cross_reference: GOC:mah

cellular protein localization
type: Class
subclass of: protein localization
subclass of: GO_0070727
definition: Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
has_alternative_id: GO:0016249
has_exact_synonym: cellular protein localisation
has_narrow_synonym: channel localizer activity
has_obo_namespace: biological_process
id: GO:0034613
in_subset: goslim drosophila

Axiom
annotated source: cellular protein localization
annotated property: definition
annotated target: Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
database_cross_reference: GOC:mah

Axiom
annotated source: cellular protein localization
annotated property: has_exact_synonym
annotated target: cellular protein localisation
database_cross_reference: GOC:mah

Axiom
annotated source: cellular protein localization
annotated property: has_narrow_synonym
annotated target: channel localizer activity
database_cross_reference: GOC:mah

cellular nitrogen compound metabolic process
type: Class
subclass of: nitrogen compound metabolic process
subclass of: cellular metabolic process
definition: The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.
has_exact_synonym: cellular nitrogen compound metabolism
has_obo_namespace: biological_process
id: GO:0034641
in_subset: goslim chembl
in_subset: goslim generic

Axiom
annotated source: cellular nitrogen compound metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.
database_cross_reference: GOC:mah

cellular response to UV
type: Class
subclass of: response to UV
subclass of: GO_0071482
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
has_exact_synonym: cellular response to UV light stimulus
has_exact_synonym: cellular response to UV radiation stimulus
has_exact_synonym: cellular response to ultraviolet light stimulus
has_exact_synonym: cellular response to ultraviolet radiation stimulus
has_obo_namespace: biological_process
id: GO:0034644

Axiom
annotated source: cellular response to UV
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
database_cross_reference: GOC:mah

cellular macromolecule biosynthetic process
type: Class
subclass of: macromolecule biosynthetic process
subclass of: cellular biosynthetic process
subclass of: cellular macromolecule metabolic process
definition: The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.
has_alternative_id: GO:0034961
has_exact_synonym: cellular biopolymer biosynthetic process
has_exact_synonym: cellular macromolecule anabolism
has_exact_synonym: cellular macromolecule biosynthesis
has_exact_synonym: cellular macromolecule formation
has_exact_synonym: cellular macromolecule synthesis
has_obo_namespace: biological_process
id: GO:0034645

Axiom
annotated source: cellular macromolecule biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.
database_cross_reference: GOC:mah

Axiom
annotated source: cellular macromolecule biosynthetic process
annotated property: has_exact_synonym
annotated target: cellular biopolymer biosynthetic process
database_cross_reference: GOC:mtg_chebi_dec09

Axiom
annotated source: cellular macromolecule biosynthetic process
annotated property: has_exact_synonym
annotated target: cellular macromolecule anabolism
database_cross_reference: GOC:mah

Axiom
annotated source: cellular macromolecule biosynthetic process
annotated property: has_exact_synonym
annotated target: cellular macromolecule biosynthesis
database_cross_reference: GOC:mah

Axiom
annotated source: cellular macromolecule biosynthetic process
annotated property: has_exact_synonym
annotated target: cellular macromolecule formation
database_cross_reference: GOC:mah

Axiom
annotated source: cellular macromolecule biosynthetic process
annotated property: has_exact_synonym
annotated target: cellular macromolecule synthesis
database_cross_reference: GOC:mah

nucleobase-containing compound biosynthetic process
type: Class
subclass of: nucleobase-containing compound metabolic process
subclass of: heterocycle biosynthetic process
subclass of: aromatic compound biosynthetic process
subclass of: cellular nitrogen compound biosynthetic process
subclass of: GO_1901362
definition: The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids.
has_exact_synonym: nucleobase, nucleoside, nucleotide and nucleic acid anabolism
has_exact_synonym: nucleobase, nucleoside, nucleotide and nucleic acid biosynthesis
has_exact_synonym: nucleobase, nucleoside, nucleotide and nucleic acid formation
has_narrow_synonym: nucleobase, nucleoside, nucleotide and nucleic acid synthesis
has_obo_namespace: biological_process
id: GO:0034654

Axiom
annotated source: nucleobase-containing compound biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids.
database_cross_reference: GOC:mah

regulation of transmembrane transport
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: GO_0055085
subclass of: GO_0050794
subclass of: GO_0051049
subclass of: Restriction
  on property: regulates
  some values from: GO_0055085
definition: Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.
has_exact_synonym: regulation of membrane transport
has_obo_namespace: biological_process
id: GO:0034762

Axiom
annotated source: regulation of transmembrane transport
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.
database_cross_reference: GOC:mah

negative regulation of transmembrane transport
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: GO_0055085
subclass of: regulation of transmembrane transport
subclass of: negative regulation of cellular process
subclass of: GO_0051051
subclass of: Restriction
  on property: negatively regulates
  some values from: GO_0055085
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.
has_exact_synonym: down regulation of transmembrane transport
has_exact_synonym: down-regulation of transmembrane transport
has_exact_synonym: downregulation of transmembrane transport
has_exact_synonym: negative regulation of membrane transport
has_narrow_synonym: inhibition of transmembrane transport
has_obo_namespace: biological_process
id: GO:0034763

Axiom
annotated source: negative regulation of transmembrane transport
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.
database_cross_reference: GOC:mah

positive regulation of transmembrane transport
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: GO_0055085
subclass of: regulation of transmembrane transport
subclass of: positive regulation of cellular process
subclass of: GO_0051050
subclass of: Restriction
  on property: positively regulates
  some values from: GO_0055085
definition: Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.
has_exact_synonym: positive regulation of membrane transport
has_exact_synonym: up regulation of transmembrane transport
has_exact_synonym: up-regulation of transmembrane transport
has_exact_synonym: upregulation of transmembrane transport
has_narrow_synonym: activation of transmembrane transport
has_narrow_synonym: stimulation of transmembrane transport
has_obo_namespace: biological_process
id: GO:0034764

Axiom
annotated source: positive regulation of transmembrane transport
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.
database_cross_reference: GOC:mah

regulation of ion transmembrane transport
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: ion transmembrane transport
subclass of: regulation of transmembrane transport
subclass of: regulation of ion transport
subclass of: Restriction
  on property: regulates
  some values from: ion transmembrane transport
definition: Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.
has_exact_synonym: regulation of ion membrane transport
has_exact_synonym: regulation of transmembrane ion transport
has_obo_namespace: biological_process
id: GO:0034765

Axiom
annotated source: regulation of ion transmembrane transport
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.
database_cross_reference: GOC:mah

Axiom
annotated source: regulation of ion transmembrane transport
annotated property: has_exact_synonym
annotated target: regulation of transmembrane ion transport
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

negative regulation of ion transmembrane transport
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: ion transmembrane transport
subclass of: negative regulation of transmembrane transport
subclass of: regulation of ion transmembrane transport
subclass of: negative regulation of ion transport
subclass of: Restriction
  on property: negatively regulates
  some values from: ion transmembrane transport
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.
has_exact_synonym: down regulation of transmembrane ion transport
has_exact_synonym: down-regulation of transmembrane ion transport
has_exact_synonym: downregulation of transmembrane ion transport
has_exact_synonym: negative regulation of ion membrane transport
has_exact_synonym: negative regulation of transmembrane ion transport
has_narrow_synonym: inhibition of transmembrane ion transport
has_obo_namespace: biological_process
id: GO:0034766

Axiom
annotated source: negative regulation of ion transmembrane transport
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.
database_cross_reference: GOC:mah

Axiom
annotated source: negative regulation of ion transmembrane transport
annotated property: has_exact_synonym
annotated target: negative regulation of transmembrane ion transport
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

positive regulation of ion transmembrane transport
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: ion transmembrane transport
subclass of: positive regulation of transmembrane transport
subclass of: regulation of ion transmembrane transport
subclass of: positive regulation of ion transport
subclass of: Restriction
  on property: positively regulates
  some values from: ion transmembrane transport
definition: Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.
has_exact_synonym: positive regulation of ion membrane transport
has_exact_synonym: positive regulation of transmembrane ion transport
has_exact_synonym: up regulation of transmembrane ion transport
has_exact_synonym: up-regulation of transmembrane ion transport
has_exact_synonym: upregulation of transmembrane ion transport
has_narrow_synonym: activation of transmembrane ion transport
has_narrow_synonym: stimulation of transmembrane ion transport
has_obo_namespace: biological_process
id: GO:0034767

Axiom
annotated source: positive regulation of ion transmembrane transport
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.
database_cross_reference: GOC:mah

axoneme assembly
type: Class
subclass of: microtubule bundle formation
subclass of: cellular component assembly
subclass of: Restriction
  on property: part of
  some values from: GO_0060271
definition: The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
has_alternative_id: GO:0035083
has_alternative_id: GO:0035084
has_exact_synonym: ciliary axoneme assembly
has_exact_synonym: cilium axoneme assembly
has_exact_synonym: flagellar axoneme assembly
has_exact_synonym: flagellum axoneme assembly
has_obo_namespace: biological_process
has_related_synonym: axoneme biogenesis
has_related_synonym: cilium axoneme biogenesis
id: GO:0035082
comment: Note that cilia and eukaryotic flagella are deemed to be equivalent.

Axiom
annotated source: axoneme assembly
annotated property: definition
annotated target: The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
database_cross_reference: GOC:bf
database_cross_reference: GOC:cilia
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0815316194

Axiom
annotated source: axoneme assembly
annotated property: has_related_synonym
annotated target: axoneme biogenesis
database_cross_reference: GOC:mah

Axiom
annotated source: axoneme assembly
annotated property: has_related_synonym
annotated target: cilium axoneme biogenesis
database_cross_reference: GOC:mah

operant conditioning
type: Class
subclass of: learning
definition: Learning to anticipate future events on the basis of past experience with the consequences of one's own behavior.
database_cross_reference: Wikipedia:Operant_conditioning
has_exact_synonym: instrumental conditioning
has_obo_namespace: biological_process
id: GO:0035106

Axiom
annotated source: operant conditioning
annotated property: definition
annotated target: Learning to anticipate future events on the basis of past experience with the consequences of one's own behavior.
database_cross_reference: PMID:14662373

social behavior
type: Class
subclass of: behavior
subclass of: GO_0051703
definition: Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group.
database_cross_reference: Wikipedia:Social_behavior
has_exact_synonym: social behaviour
has_obo_namespace: biological_process
has_related_synonym: cooperative behavior
id: GO:0035176
comment: Behavior such as predation which involves members of different species is not social. Communication between members of different species is also not social behavior.

Axiom
annotated source: social behavior
annotated property: definition
annotated target: Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group.
database_cross_reference: GOC:jh2
database_cross_reference: PMID:12848939
database_cross_reference: Wikipedia:Social_behavior

posttranscriptional gene silencing by RNA
type: Class
subclass of: posttranscriptional gene silencing
subclass of: gene silencing by RNA
definition: Any process of posttranscriptional gene inactivation (silencing) mediated by small RNA molecules that may trigger RNA (often mRNA) degradation or negatively regulate mRNA translation.
has_exact_synonym: RNA-mediated posttranscriptional gene silencing
has_obo_namespace: biological_process
has_related_synonym: sense-PTGS
id: GO:0035194

Axiom
annotated source: posttranscriptional gene silencing by RNA
annotated property: definition
annotated target: Any process of posttranscriptional gene inactivation (silencing) mediated by small RNA molecules that may trigger RNA (often mRNA) degradation or negatively regulate mRNA translation.
database_cross_reference: GOC:aruk
database_cross_reference: GOC:bc
database_cross_reference: GOC:mah
database_cross_reference: GOC:rl
database_cross_reference: PMID:15020054
database_cross_reference: PMID:15066275
database_cross_reference: PMID:15066283
database_cross_reference: PMID:23985560
database_cross_reference: PMID:28379604

Axiom
annotated source: posttranscriptional gene silencing by RNA
annotated property: has_exact_synonym
annotated target: RNA-mediated posttranscriptional gene silencing
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

tube morphogenesis
type: Class
subclass of: anatomical structure morphogenesis
subclass of: Restriction
  on property: part of
  some values from: tube development
definition: The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.
has_obo_namespace: biological_process
id: GO:0035239

Axiom
annotated source: tube morphogenesis
annotated property: definition
annotated target: The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.
database_cross_reference: GOC:bf
database_cross_reference: PMID:14624839

nuclear hormone receptor binding
type: Class
subclass of: GO_0051427
subclass of: GO_0061629
definition: Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell.
has_obo_namespace: molecular_function
id: GO:0035257

Axiom
annotated source: nuclear hormone receptor binding
annotated property: definition
annotated target: Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell.
database_cross_reference: GOC:bf

steroid hormone receptor binding
type: Class
subclass of: nuclear hormone receptor binding
definition: Interacting selectively and non-covalently with a steroid hormone receptor.
has_obo_namespace: molecular_function
id: GO:0035258

Axiom
annotated source: steroid hormone receptor binding
annotated property: definition
annotated target: Interacting selectively and non-covalently with a steroid hormone receptor.
database_cross_reference: GOC:bf

multicellular organism growth
type: Class
subclass of: multicellular organismal process
subclass of: developmental growth
definition: The increase in size or mass of an entire multicellular organism, as opposed to cell growth.
has_obo_namespace: biological_process
has_related_synonym: body growth
id: GO:0035264

Axiom
annotated source: multicellular organism growth
annotated property: definition
annotated target: The increase in size or mass of an entire multicellular organism, as opposed to cell growth.
database_cross_reference: GOC:bf
database_cross_reference: GOC:curators
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

tube development
type: Class
subclass of: anatomical structure development
subclass of: Restriction
  on property: part of
  some values from: multicellular organism development
definition: The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.
has_obo_namespace: biological_process
id: GO:0035295

Axiom
annotated source: tube development
annotated property: definition
annotated target: The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.
database_cross_reference: PMID:12526790

response to interferon-beta
type: Class
subclass of: response to cytokine
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon.
created by: rfoulger
creation date: 2010-04-16T11:06:12Z
has_exact_synonym: response to fiblaferon
has_exact_synonym: response to fibroblast interferon
has_exact_synonym: response to interferon beta
has_obo_namespace: biological_process
has_related_synonym: response to beta-1 interferon
id: GO:0035456

Axiom
annotated source: response to interferon-beta
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon.
database_cross_reference: GOC:sl
database_cross_reference: PMID:9561374
database_cross_reference: PR:000008924

Axiom
annotated source: response to interferon-beta
annotated property: has_exact_synonym
annotated target: response to fiblaferon
database_cross_reference: GOC:sl

Axiom
annotated source: response to interferon-beta
annotated property: has_exact_synonym
annotated target: response to fibroblast interferon
database_cross_reference: GOC:sl

Axiom
annotated source: response to interferon-beta
annotated property: has_exact_synonym
annotated target: response to interferon beta
database_cross_reference: GOC:hp
database_cross_reference: PR:000008924

Axiom
annotated source: response to interferon-beta
annotated property: has_related_synonym
annotated target: response to beta-1 interferon
database_cross_reference: GOC:sl

vitamin transmembrane transport
type: Class
subclass of: GO_0051180
subclass of: GO_0055085
definition: The process in which a vitamin is transported across a membrane. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.
created by: rfoulger
creation date: 2010-04-19T10:21:41Z
has_exact_synonym: vitamin membrane transport
has_obo_namespace: biological_process
id: GO:0035461
comment: Note that this term is not intended for use in annotating lateral movement within membranes.

Axiom
annotated source: vitamin transmembrane transport
annotated property: definition
annotated target: The process in which a vitamin is transported across a membrane. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.
database_cross_reference: GOC:bf

positive regulation of vascular wound healing
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: GO_0061042
subclass of: positive regulation of angiogenesis
subclass of: GO_0061043
subclass of: GO_0090303
subclass of: Restriction
  on property: positively regulates
  some values from: GO_0061042
definition: Any process that increases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature.
created by: rfoulger
creation date: 2010-04-22T10:49:09Z
has_obo_namespace: biological_process
id: GO:0035470

Axiom
annotated source: positive regulation of vascular wound healing
annotated property: definition
annotated target: Any process that increases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature.
database_cross_reference: GOC:rph

intracellular signal transduction
type: Class
equivalent class: Class
  intersection of: signal transduction
  intersection of: Restriction
    on property: occurs in
    some values from: intracellular
subclass of: signal transduction
subclass of: Restriction
  on property: occurs in
  some values from: intracellular
definition: The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
created by: rfoulger
creation date: 2010-05-14T01:14:37Z
has_alternative_id: GO:0007242
has_alternative_id: GO:0007243
has_alternative_id: GO:0023013
has_alternative_id: GO:0023034
has_exact_synonym: intracellular signaling chain
has_narrow_synonym: intracellular protein kinase cascade
has_narrow_synonym: intracellular signal transduction pathway
has_narrow_synonym: protein kinase cascade
has_narrow_synonym: signal transmission via intracellular cascade
has_obo_namespace: biological_process
has_related_synonym: intracellular signaling cascade
has_related_synonym: intracellular signaling pathway
has_related_synonym: signal transduction via intracellular signaling cascade
id: GO:0035556
in_subset: goslim drosophila

Axiom
annotated source: intracellular signal transduction
annotated property: definition
annotated target: The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
database_cross_reference: GOC:bf
database_cross_reference: GOC:jl
database_cross_reference: GOC:signaling
database_cross_reference: ISBN:3527303782

Axiom
annotated source: intracellular signal transduction
annotated property: has_exact_synonym
annotated target: intracellular signaling chain
database_cross_reference: ISBN:3527303782

Axiom
annotated source: intracellular signal transduction
annotated property: has_narrow_synonym
annotated target: intracellular protein kinase cascade
database_cross_reference: GOC:signaling

Axiom
annotated source: intracellular signal transduction
annotated property: has_narrow_synonym
annotated target: protein kinase cascade
database_cross_reference: GOC:signaling

Axiom
annotated source: intracellular signal transduction
annotated property: has_related_synonym
annotated target: intracellular signaling cascade
database_cross_reference: GOC:signaling

establishment of protein localization to extracellular region
type: Class
subclass of: establishment of protein localization
subclass of: GO_0071692
definition: The directed movement of a protein to a specific location within the extracellular region.
created by: rfoulger
creation date: 2010-11-09T10:25:08Z
has_exact_synonym: establishment of protein localisation in extracellular region
has_exact_synonym: establishment of protein localization in extracellular region
has_obo_namespace: biological_process
id: GO:0035592

Axiom
annotated source: establishment of protein localization to extracellular region
annotated property: definition
annotated target: The directed movement of a protein to a specific location within the extracellular region.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:bf

Axiom
annotated source: establishment of protein localization to extracellular region
annotated property: has_exact_synonym
annotated target: establishment of protein localisation in extracellular region
database_cross_reference: GOC:mah

intraciliary transport involved in cilium assembly
type: Class
equivalent class: Class
  intersection of: intraciliary transport
  intersection of: Restriction
    on property: part of
    some values from: GO_0060271
subclass of: intraciliary transport
subclass of: Restriction
  on property: part of
  some values from: GO_0060271
definition: The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly.
created by: rfoulger
creation date: 2011-03-17T10:55:42Z
has_broad_synonym: intraflagellar transport
database_cross_reference: Reactome:R-HSA-5620924.2
has_obo_namespace: biological_process
has_related_synonym: intraciliary transport involved in cilium morphogenesis
has_related_synonym: intraflagellar transport involved in cilium morphogenesis
id: GO:0035735

Axiom
annotated source: intraciliary transport involved in cilium assembly
annotated property: definition
annotated target: The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly.
database_cross_reference: GOC:bf
database_cross_reference: GOC:cilia
database_cross_reference: Reactome:R-HSA-5620924.2

modulation of process of other organism
type: Class
subclass of: interspecies interaction between organisms
definition: The process in which an organism effects a change in the structure or processes of another organism.
IAO_0000233: https://github.com/geneontology/go-ontology/issues/18605
created by: rfoulger
creation date: 2011-04-21T01:31:51Z
has_exact_synonym: modification of morphology or physiology of other organism
has_narrow_synonym: regulation of morphology of other organism
has_narrow_synonym: regulation of physiological process of other organism
has_narrow_synonym: regulation of physiology of other organism
has_obo_namespace: biological_process
has_related_synonym: regulation of morphology or physiology of other organism
id: GO:0035821

Axiom
annotated source: modulation of process of other organism
annotated property: definition
annotated target: The process in which an organism effects a change in the structure or processes of another organism.
database_cross_reference: GOC:bf

Axiom
annotated source: modulation of process of other organism
annotated property: has_narrow_synonym
annotated target: regulation of morphology of other organism
database_cross_reference: GOC:bf

Axiom
annotated source: modulation of process of other organism
annotated property: has_narrow_synonym
annotated target: regulation of physiological process of other organism
database_cross_reference: GOC:bf

Axiom
annotated source: modulation of process of other organism
annotated property: has_narrow_synonym
annotated target: regulation of physiology of other organism
database_cross_reference: GOC:bf

Axiom
annotated source: modulation of process of other organism
annotated property: has_related_synonym
annotated target: regulation of morphology or physiology of other organism
database_cross_reference: GOC:bf

negative regulation of peptidase activity in other organism
type: Class
subclass of: negative regulation of peptidase activity
subclass of: negative regulation of molecular function in other organism
definition: Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of peptidase activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism.
created by: rfoulger
creation date: 2011-07-22T02:59:40Z
has_exact_synonym: down regulation of peptidase activity in other organism
has_exact_synonym: downregulation of peptidase activity in other organism
has_narrow_synonym: down-regulation of protease activity in other organism
has_narrow_synonym: inhibition of protease activity in other organism
has_narrow_synonym: negative regulation of protease activity in other organism
has_obo_namespace: biological_process
id: GO:0035940

Axiom
annotated source: negative regulation of peptidase activity in other organism
annotated property: definition
annotated target: Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of peptidase activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism.
database_cross_reference: GOC:klp
database_cross_reference: PMID:10595640

Axiom
annotated source: negative regulation of peptidase activity in other organism
annotated property: has_exact_synonym
annotated target: down regulation of peptidase activity in other organism
database_cross_reference: GOC:bf

Axiom
annotated source: negative regulation of peptidase activity in other organism
annotated property: has_exact_synonym
annotated target: downregulation of peptidase activity in other organism
database_cross_reference: GOC:bf

Axiom
annotated source: negative regulation of peptidase activity in other organism
annotated property: has_narrow_synonym
annotated target: down-regulation of protease activity in other organism
database_cross_reference: GOC:bf

Axiom
annotated source: negative regulation of peptidase activity in other organism
annotated property: has_narrow_synonym
annotated target: inhibition of protease activity in other organism
database_cross_reference: GOC:bf

Axiom
annotated source: negative regulation of peptidase activity in other organism
annotated property: has_narrow_synonym
annotated target: negative regulation of protease activity in other organism
database_cross_reference: GOC:bf

protein modification process
type: Class
subclass of: protein metabolic process
subclass of: macromolecule modification
definition: The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
created by: rfoulger
creation date: 2012-04-26T01:47:12Z
has_exact_synonym: protein modification
has_obo_namespace: biological_process
id: GO:0036211

Axiom
annotated source: protein modification process
annotated property: definition
annotated target: The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
database_cross_reference: GOC:bf
database_cross_reference: GOC:jl

Axiom
annotated source: protein modification process
annotated property: has_exact_synonym
annotated target: protein modification
database_cross_reference: GOC:bf

response to diuretic
type: Class
subclass of: response to drug
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diuretic stimulus. A diuretic is an agent that promotes the excretion of urine through its effects on kidney function.
created by: rfoulger
creation date: 2012-07-09T01:26:24Z
has_obo_namespace: biological_process
id: GO:0036270
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to diuretic
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diuretic stimulus. A diuretic is an agent that promotes the excretion of urine through its effects on kidney function.
database_cross_reference: GOC:hp

response to methylphenidate
type: Class
subclass of: response to drug
subclass of: GO_1901698
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylphenidate stimulus.
created by: rfoulger
creation date: 2012-07-09T01:30:57Z
has_exact_synonym: response to MPD
has_exact_synonym: response to MPH
has_exact_synonym: response to ritalin
has_obo_namespace: biological_process
id: GO:0036271
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to methylphenidate
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylphenidate stimulus.
database_cross_reference: GOC:hp
database_cross_reference: Wikipedia:Methylphenidate

Axiom
annotated source: response to methylphenidate
annotated property: has_exact_synonym
annotated target: response to MPD
database_cross_reference: CHEBI:6887

Axiom
annotated source: response to methylphenidate
annotated property: has_exact_synonym
annotated target: response to MPH
database_cross_reference: CHEBI:6887

Axiom
annotated source: response to methylphenidate
annotated property: has_exact_synonym
annotated target: response to ritalin
database_cross_reference: CHEBI:6887

response to gemcitabine
type: Class
subclass of: response to xenobiotic stimulus
subclass of: response to organonitrogen compound
subclass of: response to organic cyclic compound
subclass of: response to antibiotic
subclass of: GO_0097327
subclass of: GO_0097329
subclass of: GO_1901700
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gemcitabine stimulus. Gemcitabine is a 2'-deoxycytidine having geminal fluoro substituents in the 2'-position, and is used as a drug in the treatment of various carcinomas.
created by: rfoulger
creation date: 2012-07-09T01:36:03Z
has_exact_synonym: response to 2',2'-difluorodeoxycytidine
has_exact_synonym: response to 2'-deoxy-2',2'-difluorocytidine
has_obo_namespace: biological_process
id: GO:0036272
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to gemcitabine
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gemcitabine stimulus. Gemcitabine is a 2'-deoxycytidine having geminal fluoro substituents in the 2'-position, and is used as a drug in the treatment of various carcinomas.
database_cross_reference: GOC:hp
database_cross_reference: Wikipedia:Gemcitabine

Axiom
annotated source: response to gemcitabine
annotated property: has_exact_synonym
annotated target: response to 2',2'-difluorodeoxycytidine
database_cross_reference: CHEBI:175901

Axiom
annotated source: response to gemcitabine
annotated property: has_exact_synonym
annotated target: response to 2'-deoxy-2',2'-difluorocytidine
database_cross_reference: CHEBI:175901

response to statin
type: Class
subclass of: response to organic substance
subclass of: response to drug
subclass of: GO_1901700
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a statin stimulus. Statins are organooxygen compounds whose structure is related to compactin (mevastatin) and which may be used as an anticholesteremic drug due its EC:1.1.1.34/EC:1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitory properties.
created by: rfoulger
creation date: 2012-07-09T01:54:01Z
has_obo_namespace: biological_process
has_related_synonym: response to HMG-CoA reductase inhibitor
has_related_synonym: response to hydroxymethylglutaryl-CoA reductase inhibitor
id: GO:0036273
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to statin
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a statin stimulus. Statins are organooxygen compounds whose structure is related to compactin (mevastatin) and which may be used as an anticholesteremic drug due its EC:1.1.1.34/EC:1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitory properties.
database_cross_reference: GOC:hp

Axiom
annotated source: response to statin
annotated property: has_related_synonym
annotated target: response to HMG-CoA reductase inhibitor
database_cross_reference: CHEBI:35664

Axiom
annotated source: response to statin
annotated property: has_related_synonym
annotated target: response to hydroxymethylglutaryl-CoA reductase inhibitor
database_cross_reference: CHEBI:35664

response to lapatinib
type: Class
subclass of: response to organonitrogen compound
subclass of: response to organic cyclic compound
subclass of: GO_0097327
subclass of: GO_1901700
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lapatinib stimulus.
created by: rfoulger
creation date: 2012-07-09T02:02:26Z
has_obo_namespace: biological_process
id: GO:0036274
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to lapatinib
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lapatinib stimulus.
database_cross_reference: GOC:hp

response to 5-fluorouracil
type: Class
subclass of: response to xenobiotic stimulus
subclass of: response to organic cyclic compound
subclass of: GO_0097327
subclass of: GO_0097329
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluorouracil stimulus.
created by: rfoulger
creation date: 2012-07-09T02:08:23Z
has_exact_synonym: response to 5-fluoropyrimidine-2,4(1H,3H)-dione
has_exact_synonym: response to fluorouracil
has_obo_namespace: biological_process
id: GO:0036275
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to 5-fluorouracil
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluorouracil stimulus.
database_cross_reference: GOC:hp

Axiom
annotated source: response to 5-fluorouracil
annotated property: has_exact_synonym
annotated target: response to 5-fluoropyrimidine-2,4(1H,3H)-dione
database_cross_reference: CHEBI:46345

Axiom
annotated source: response to 5-fluorouracil
annotated property: has_exact_synonym
annotated target: response to fluorouracil
database_cross_reference: GOC:hp

response to antidepressant
type: Class
subclass of: response to drug
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antidepressant stimulus, a mood-stimulating drug.
created by: rfoulger
creation date: 2012-07-09T02:12:44Z
has_obo_namespace: biological_process
id: GO:0036276
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to antidepressant
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antidepressant stimulus, a mood-stimulating drug.
database_cross_reference: GOC:hp

response to anticonvulsant
type: Class
subclass of: response to drug
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticonvulsant stimulus, a drug used to prevent seizures or reduce their severity.
created by: rfoulger
creation date: 2012-07-09T02:40:12Z
has_obo_namespace: biological_process
id: GO:0036277
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to anticonvulsant
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticonvulsant stimulus, a drug used to prevent seizures or reduce their severity.
database_cross_reference: GOC:hp

response to iloperidone
type: Class
subclass of: response to organic cyclic compound
subclass of: response to ether
subclass of: GO_0071867
subclass of: GO_0097332
subclass of: GO_1901654
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iloperidone stimulus.
created by: rfoulger
creation date: 2012-07-16T05:01:29Z
has_obo_namespace: biological_process
id: GO:0036287
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to iloperidone
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iloperidone stimulus.
database_cross_reference: GOC:hp

response to ximelagatran
type: Class
subclass of: response to organonitrogen compound
subclass of: response to organic cyclic compound
subclass of: GO_0061476
subclass of: GO_1901700
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ximelagatran stimulus.
created by: rfoulger
creation date: 2012-07-16T05:03:56Z
has_obo_namespace: biological_process
id: GO:0036288
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to ximelagatran
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ximelagatran stimulus.
database_cross_reference: GOC:hp

nucleoid DNA packaging
type: Class
equivalent class: Class
  intersection of: DNA packaging
  intersection of: Restriction
    on property: occurs in
    some values from: nucleoid
subclass of: DNA packaging
subclass of: Restriction
  on property: occurs in
  some values from: nucleoid
definition: Any process in which DNA and associated proteins are formed into a compact, orderly structure within a nucleoid.
created by: rfoulger
creation date: 2013-05-30T10:36:05Z
has_obo_namespace: biological_process
id: GO:0036385

Axiom
annotated source: nucleoid DNA packaging
annotated property: definition
annotated target: Any process in which DNA and associated proteins are formed into a compact, orderly structure within a nucleoid.
database_cross_reference: GOC:bf
database_cross_reference: GOC:bhm

bacterial nucleoid DNA packaging
type: Class
equivalent class: Class
  intersection of: DNA packaging
  intersection of: Restriction
    on property: occurs in
    some values from: bacterial nucleoid
subclass of: nucleoid DNA packaging
subclass of: Restriction
  on property: occurs in
  some values from: bacterial nucleoid
definition: Compaction of DNA in a bacterial nucleoid into a compact structure. Often achieved by DNA supercoiling.
created by: rfoulger
creation date: 2013-05-30T10:41:08Z
has_broad_synonym: chromosomal compaction
has_broad_synonym: nucleoid compaction
has_broad_synonym: prokaryotic DNA condensation
has_obo_namespace: biological_process
id: GO:0036386

Axiom
annotated source: bacterial nucleoid DNA packaging
annotated property: definition
annotated target: Compaction of DNA in a bacterial nucleoid into a compact structure. Often achieved by DNA supercoiling.
database_cross_reference: GOC:bf
database_cross_reference: GOC:bhm
database_cross_reference: PMID:17097674
database_cross_reference: PMID:17360520

Axiom
annotated source: bacterial nucleoid DNA packaging
annotated property: has_broad_synonym
annotated target: chromosomal compaction
database_cross_reference: PMID:17097674

Axiom
annotated source: bacterial nucleoid DNA packaging
annotated property: has_broad_synonym
annotated target: nucleoid compaction
database_cross_reference: PMID:17097674

Axiom
annotated source: bacterial nucleoid DNA packaging
annotated property: has_broad_synonym
annotated target: prokaryotic DNA condensation
database_cross_reference: Wikipedia:DNA_condensation

signaling receptor activity
type: Class
subclass of: GO_0060089
definition: Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
created by: rfoulger
creation date: 2011-08-01T02:45:27Z
has_alternative_id: GO:0004872
has_alternative_id: GO:0019041
has_broad_synonym: receptor activity
has_exact_synonym: receptor activity involved in signal transduction
has_obo_namespace: molecular_function
id: GO:0038023
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant

Axiom
annotated source: signaling receptor activity
annotated property: definition
annotated target: Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
database_cross_reference: GOC:bf
database_cross_reference: GOC:signaling

Axiom
annotated source: signaling receptor activity
annotated property: has_exact_synonym
annotated target: receptor activity involved in signal transduction
database_cross_reference: GOC:bf

growth
type: Class
subclass of: biological_process
disjoint with: biological phase
definition: The increase in size or mass of an entire organism, a part of an organism or a cell.
has_alternative_id: GO:0048590
has_obo_namespace: biological_process
has_related_synonym: growth pattern
has_related_synonym: non-developmental growth
id: GO:0040007
in_subset: gocheck do not annotate
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant
comment: See also the biological process term 'cell growth ; GO:0016049'.

Axiom
annotated source: growth
annotated property: definition
annotated target: The increase in size or mass of an entire organism, a part of an organism or a cell.
database_cross_reference: GOC:bf
database_cross_reference: GOC:ma

Axiom
annotated source: growth
annotated property: has_related_synonym
annotated target: non-developmental growth
database_cross_reference: GOC:mah

regulation of growth
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: growth
subclass of: GO_0050789
subclass of: Restriction
  on property: regulates
  some values from: growth
definition: Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development.
has_obo_namespace: biological_process
id: GO:0040008

Axiom
annotated source: regulation of growth
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development.
database_cross_reference: GOC:ems
database_cross_reference: GOC:mah

locomotion
type: Class
subclass of: biological_process
disjoint with: biological phase
definition: Self-propelled movement of a cell or organism from one location to another.
never in taxon: NCBITaxon_451864
has_obo_namespace: biological_process
id: GO:0040011
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim pir

Axiom
annotated source: locomotion
annotated property: definition
annotated target: Self-propelled movement of a cell or organism from one location to another.
database_cross_reference: GOC:dgh

regulation of locomotion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: locomotion
subclass of: GO_0050789
subclass of: Restriction
  on property: regulates
  some values from: locomotion
definition: Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.
has_obo_namespace: biological_process
id: GO:0040012

Axiom
annotated source: regulation of locomotion
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.
database_cross_reference: GOC:ems

negative regulation of locomotion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: locomotion
subclass of: regulation of locomotion
subclass of: negative regulation of biological process
subclass of: Restriction
  on property: negatively regulates
  some values from: locomotion
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism.
has_exact_synonym: down regulation of locomotion
has_exact_synonym: down-regulation of locomotion
has_exact_synonym: downregulation of locomotion
has_narrow_synonym: inhibition of locomotion
has_obo_namespace: biological_process
id: GO:0040013

Axiom
annotated source: negative regulation of locomotion
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism.
database_cross_reference: GOC:go_curators

regulation of multicellular organism growth
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: multicellular organism growth
subclass of: regulation of developmental growth
subclass of: GO_0051239
subclass of: Restriction
  on property: regulates
  some values from: multicellular organism growth
definition: Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.
has_exact_synonym: regulation of body growth
has_exact_synonym: regulation of body size
has_obo_namespace: biological_process
id: GO:0040014

Axiom
annotated source: regulation of multicellular organism growth
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.
database_cross_reference: GOC:dph
database_cross_reference: GOC:ems
database_cross_reference: GOC:tb

Axiom
annotated source: regulation of multicellular organism growth
annotated property: has_exact_synonym
annotated target: regulation of body growth
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

Axiom
annotated source: regulation of multicellular organism growth
annotated property: has_exact_synonym
annotated target: regulation of body size
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

negative regulation of multicellular organism growth
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: multicellular organism growth
subclass of: regulation of multicellular organism growth
subclass of: negative regulation of developmental growth
subclass of: GO_0051241
subclass of: Restriction
  on property: negatively regulates
  some values from: multicellular organism growth
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size.
has_exact_synonym: negative regulation of body growth
has_exact_synonym: negative regulation of body size
has_obo_namespace: biological_process
id: GO:0040015

Axiom
annotated source: negative regulation of multicellular organism growth
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size.
database_cross_reference: GOC:dph
database_cross_reference: GOC:ems
database_cross_reference: GOC:tb

Axiom
annotated source: negative regulation of multicellular organism growth
annotated property: has_exact_synonym
annotated target: negative regulation of body growth
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

Axiom
annotated source: negative regulation of multicellular organism growth
annotated property: has_exact_synonym
annotated target: negative regulation of body size
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

embryonic cleavage
type: Class
subclass of: GO_0051301
subclass of: Restriction
  on property: part of
  some values from: embryo development
definition: The first few specialized divisions of an activated animal egg.
has_obo_namespace: biological_process
id: GO:0040016

Axiom
annotated source: embryonic cleavage
annotated property: definition
annotated target: The first few specialized divisions of an activated animal egg.
database_cross_reference: GOC:clt
database_cross_reference: ISBN:0070524300

positive regulation of locomotion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: locomotion
subclass of: regulation of locomotion
subclass of: positive regulation of biological process
subclass of: Restriction
  on property: positively regulates
  some values from: locomotion
definition: Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.
has_exact_synonym: up regulation of locomotion
has_exact_synonym: up-regulation of locomotion
has_exact_synonym: upregulation of locomotion
has_narrow_synonym: activation of locomotion
has_narrow_synonym: stimulation of locomotion
has_obo_namespace: biological_process
id: GO:0040017

Axiom
annotated source: positive regulation of locomotion
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.
database_cross_reference: GOC:go_curators

positive regulation of multicellular organism growth
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: multicellular organism growth
subclass of: regulation of multicellular organism growth
subclass of: positive regulation of developmental growth
subclass of: GO_0051240
subclass of: Restriction
  on property: positively regulates
  some values from: multicellular organism growth
definition: Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
has_exact_synonym: positive regulation of body growth
has_exact_synonym: positive regulation of body size
has_obo_namespace: biological_process
id: GO:0040018

Axiom
annotated source: positive regulation of multicellular organism growth
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
database_cross_reference: GOC:dph
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:tb

Axiom
annotated source: positive regulation of multicellular organism growth
annotated property: has_exact_synonym
annotated target: positive regulation of body growth
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

Axiom
annotated source: positive regulation of multicellular organism growth
annotated property: has_exact_synonym
annotated target: positive regulation of body size
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

positive regulation of embryonic development
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: embryo development
subclass of: regulation of embryonic development
subclass of: GO_0051094
subclass of: GO_0051240
subclass of: Restriction
  on property: positively regulates
  some values from: embryo development
definition: Any process that activates or increases the frequency, rate or extent of embryonic development.
has_exact_synonym: up regulation of embryonic development
has_exact_synonym: up-regulation of embryonic development
has_exact_synonym: upregulation of embryonic development
has_narrow_synonym: activation of embryonic development
has_narrow_synonym: stimulation of embryonic development
has_obo_namespace: biological_process
id: GO:0040019

Axiom
annotated source: positive regulation of embryonic development
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of embryonic development.
database_cross_reference: GOC:go_curators

regulation of meiotic nuclear division
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: GO_0140013
subclass of: regulation of cell cycle process
subclass of: GO_0051445
subclass of: GO_0051783
subclass of: Restriction
  on property: regulates
  some values from: GO_0140013
definition: Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes.
has_broad_synonym: regulation of meiosis
has_obo_namespace: biological_process
id: GO:0040020

Axiom
annotated source: regulation of meiotic nuclear division
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes.
database_cross_reference: GOC:ems
database_cross_reference: GOC:ma

Axiom
annotated source: regulation of meiotic nuclear division
annotated property: has_broad_synonym
annotated target: regulation of meiosis
database_cross_reference: GOC:vw

regulation of gene expression, epigenetic
type: Class
subclass of: regulation of gene expression
definition: Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence.
has_obo_namespace: biological_process
id: GO:0040029
in_subset: goslim plant

Axiom
annotated source: regulation of gene expression, epigenetic
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence.
database_cross_reference: PMID:10521337
database_cross_reference: PMID:11498582

host cell nucleus
type: Class
subclass of: host intracellular membrane-bounded organelle
definition: A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has_alternative_id: GO:0033649
has_obo_namespace: cellular_component
id: GO:0042025

Axiom
annotated source: host cell nucleus
annotated property: definition
annotated target: A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.
database_cross_reference: GOC:pamgo_curators

olfactory behavior
type: Class
subclass of: chemosensory behavior
definition: The behavior of an organism in response to an odor.
has_exact_synonym: behavioral response to scent
has_exact_synonym: behavioral response to smell
has_exact_synonym: behavioural response to odour
has_exact_synonym: behavioural response to scent
has_exact_synonym: behavioural response to smell
has_exact_synonym: olfactory behaviour
has_obo_namespace: biological_process
id: GO:0042048

Axiom
annotated source: olfactory behavior
annotated property: definition
annotated target: The behavior of an organism in response to an odor.
database_cross_reference: GOC:jid
database_cross_reference: GOC:pr

wound healing
type: Class
subclass of: response to wounding
definition: The series of events that restore integrity to a damaged tissue, following an injury.
database_cross_reference: Wikipedia:Wound_healing
has_obo_namespace: biological_process
id: GO:0042060

Axiom
annotated source: wound healing
annotated property: definition
annotated target: The series of events that restore integrity to a damaged tissue, following an injury.
database_cross_reference: GOC:bf
database_cross_reference: PMID:15269788

intraciliary transport
type: Class
subclass of: protein-containing complex localization
subclass of: GO_0098840
subclass of: Restriction
  on property: part of
  some values from: cilium organization
subclass of: Restriction
  on property: occurs in
  some values from: cilium
definition: The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins.
never in taxon: NCBITaxon 3176
never in taxon: NCBITaxon 3312
never in taxon: NCBITaxon 3378
never in taxon: NCBITaxon 3398
never in taxon: NCBITaxon 4890
never in taxon: NCBITaxon 5782
has_alternative_id: GO:0035734
database_cross_reference: Wikipedia:Intraflagellar_transport
has_exact_synonym: intraflagellar transport
has_exact_synonym: intraflagellar transport involved in cilium organization
has_exact_synonym: intraflagellar transport involved in microtubule-based flagellum organisation
has_obo_namespace: biological_process
has_related_synonym: IFT
id: GO:0042073
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.

Axiom
annotated source: intraciliary transport
annotated property: definition
annotated target: The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins.
database_cross_reference: GOC:cilia
database_cross_reference: GOC:kmv
database_cross_reference: PMID:17981739
database_cross_reference: PMID:18180368
database_cross_reference: PMID:22869374
database_cross_reference: Reactome:R-HSA-5620924.2

germ-line stem cell division
type: Class
subclass of: stem cell division
subclass of: cellular process involved in reproduction in multicellular organism
subclass of: Restriction
  on property: part of
  some values from: germ cell development
definition: The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes.
has_alternative_id: GO:0048131
has_exact_synonym: germ-line stem cell renewal
has_obo_namespace: biological_process
id: GO:0042078

Axiom
annotated source: germ-line stem cell division
annotated property: definition
annotated target: The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes.
database_cross_reference: GOC:jid
database_cross_reference: PMID:2279698

macrophage activation
type: Class
subclass of: myeloid leukocyte activation
definition: A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
has_exact_synonym: macrophage polarization
has_obo_namespace: biological_process
id: GO:0042116

Axiom
annotated source: macrophage activation
annotated property: definition
annotated target: A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
database_cross_reference: GOC:mgi_curators
database_cross_reference: ISBN:0781735149
database_cross_reference: PMID:14506301

regulation of cell population proliferation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cell population proliferation
subclass of: GO_0050794
subclass of: Restriction
  on property: regulates
  some values from: cell population proliferation
definition: Any process that modulates the frequency, rate or extent of cell proliferation.
never in taxon: NCBITaxon 4751
has_obo_namespace: biological_process
has_related_synonym: regulation of cell proliferation
id: GO:0042127

Axiom
annotated source: regulation of cell population proliferation
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of cell proliferation.
database_cross_reference: GOC:jl

plastid membrane
type: Class
subclass of: organelle membrane
subclass of: Restriction
  on property: part of
  some values from: plastid envelope
definition: Either of the lipid bilayers that surround a plastid and form the plastid envelope.
has_obo_namespace: cellular_component
id: GO:0042170

Axiom
annotated source: plastid membrane
annotated property: definition
annotated target: Either of the lipid bilayers that surround a plastid and form the plastid envelope.
database_cross_reference: GOC:mah

terpene metabolic process
type: Class
subclass of: isoprenoid metabolic process
definition: The chemical reactions and pathways involving terpenes, any of a large group of hydrocarbons that are made up of isoprene (C5H8) units which may be cyclic, acyclic or multicyclic, saturated or unsaturated, and may contain various functional groups.
has_exact_synonym: terpene metabolism
has_obo_namespace: biological_process
id: GO:0042214

Axiom
annotated source: terpene metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving terpenes, any of a large group of hydrocarbons that are made up of isoprene (C5H8) units which may be cyclic, acyclic or multicyclic, saturated or unsaturated, and may contain various functional groups.
database_cross_reference: GOC:curators

response to chemical
type: Class
subclass of: GO_0050896
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.
has_exact_synonym: response to chemical stimulus
has_exact_synonym: response to chemical substance
has_obo_namespace: biological_process
id: GO:0042221
in_subset: gocheck do not manually annotate
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim plant
in_subset: goslim yeast
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to chemical
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.
database_cross_reference: GOC:jl

Axiom
annotated source: response to chemical
annotated property: has_exact_synonym
annotated target: response to chemical stimulus
database_cross_reference: GOC:dos

purine nucleoside metabolic process
type: Class
subclass of: nucleoside metabolic process
subclass of: GO_0072521
definition: The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).
has_broad_synonym: purine metabolic process
has_broad_synonym: purine metabolism
has_exact_synonym: purine nucleoside metabolism
has_obo_namespace: biological_process
id: GO:0042278

Axiom
annotated source: purine nucleoside metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0140512713

regulation of circadian sleep/wake cycle, REM sleep
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: circadian sleep/wake cycle, REM sleep
subclass of: regulation of circadian sleep/wake cycle, sleep
subclass of: Restriction
  on property: regulates
  some values from: circadian sleep/wake cycle, REM sleep
definition: Any process that modulates the frequency, rate or extent of rapid eye movement (REM) sleep.
has_exact_synonym: regulation of REM sleep
has_obo_namespace: biological_process
id: GO:0042320

Axiom
annotated source: regulation of circadian sleep/wake cycle, REM sleep
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of rapid eye movement (REM) sleep.
database_cross_reference: GOC:jl
database_cross_reference: PMID:11506998

negative regulation of circadian sleep/wake cycle, sleep
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: GO_0050802
subclass of: negative regulation of circadian rhythm
subclass of: regulation of circadian sleep/wake cycle, sleep
subclass of: negative regulation of behavior
subclass of: GO_0051241
subclass of: Restriction
  on property: negatively regulates
  some values from: GO_0050802
definition: Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.
has_exact_synonym: down regulation of circadian sleep/wake cycle, sleep
has_exact_synonym: down-regulation of circadian sleep/wake cycle, sleep
has_exact_synonym: downregulation of circadian sleep/wake cycle, sleep
has_exact_synonym: negative regulation of sleep
has_narrow_synonym: inhibition of circadian sleep/wake cycle, sleep
has_obo_namespace: biological_process
id: GO:0042321

Axiom
annotated source: negative regulation of circadian sleep/wake cycle, sleep
annotated property: definition
annotated target: Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0192800981

negative regulation of circadian sleep/wake cycle, REM sleep
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: circadian sleep/wake cycle, REM sleep
subclass of: regulation of circadian sleep/wake cycle, REM sleep
subclass of: negative regulation of circadian sleep/wake cycle, sleep
subclass of: Restriction
  on property: negatively regulates
  some values from: circadian sleep/wake cycle, REM sleep
definition: Any process that stops, prevents or reduces the duration or quality of rapid eye movement (REM) sleep.
has_exact_synonym: down regulation of circadian sleep/wake cycle, REM sleep
has_exact_synonym: down-regulation of circadian sleep/wake cycle, REM sleep
has_exact_synonym: downregulation of circadian sleep/wake cycle, REM sleep
has_exact_synonym: negative regulation of REM sleep
has_narrow_synonym: inhibition of circadian sleep/wake cycle, REM sleep
has_obo_namespace: biological_process
id: GO:0042322

Axiom
annotated source: negative regulation of circadian sleep/wake cycle, REM sleep
annotated property: definition
annotated target: Any process that stops, prevents or reduces the duration or quality of rapid eye movement (REM) sleep.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:jl

negative regulation of circadian sleep/wake cycle, non-REM sleep
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: circadian sleep/wake cycle, non-REM sleep
subclass of: negative regulation of circadian sleep/wake cycle, sleep
subclass of: regulation of circadian sleep/wake cycle, non-REM sleep
subclass of: Restriction
  on property: negatively regulates
  some values from: circadian sleep/wake cycle, non-REM sleep
definition: Any process that stops, prevents or reduces the duration or quality of non-rapid eye movement (NREM) sleep.
has_exact_synonym: down regulation of circadian sleep/wake cycle, non-REM sleep
has_exact_synonym: down-regulation of circadian sleep/wake cycle, non-REM sleep
has_exact_synonym: downregulation of circadian sleep/wake cycle, non-REM sleep
has_exact_synonym: negative regulation of non-REM sleep
has_narrow_synonym: inhibition of circadian sleep/wake cycle, non-REM sleep
has_obo_namespace: biological_process
id: GO:0042323

Axiom
annotated source: negative regulation of circadian sleep/wake cycle, non-REM sleep
annotated property: definition
annotated target: Any process that stops, prevents or reduces the duration or quality of non-rapid eye movement (NREM) sleep.
database_cross_reference: GOC:jl

regulation of phosphorylation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: phosphorylation
subclass of: regulation of phosphate metabolic process
subclass of: Restriction
  on property: regulates
  some values from: phosphorylation
definition: Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule.
has_obo_namespace: biological_process
id: GO:0042325

Axiom
annotated source: regulation of phosphorylation
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule.
database_cross_reference: GOC:jl

negative regulation of phosphorylation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: phosphorylation
subclass of: regulation of phosphorylation
subclass of: negative regulation of phosphate metabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: phosphorylation
definition: Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule.
has_exact_synonym: down regulation of phosphorylation
has_exact_synonym: down-regulation of phosphorylation
has_exact_synonym: downregulation of phosphorylation
has_narrow_synonym: inhibition of phosphorylation
has_obo_namespace: biological_process
id: GO:0042326

Axiom
annotated source: negative regulation of phosphorylation
annotated property: definition
annotated target: Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule.
database_cross_reference: GOC:jl

positive regulation of phosphorylation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: phosphorylation
subclass of: regulation of phosphorylation
subclass of: positive regulation of phosphate metabolic process
subclass of: Restriction
  on property: positively regulates
  some values from: phosphorylation
definition: Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.
has_exact_synonym: up regulation of phosphorylation
has_exact_synonym: up-regulation of phosphorylation
has_exact_synonym: upregulation of phosphorylation
has_narrow_synonym: activation of phosphorylation
has_narrow_synonym: stimulation of phosphorylation
has_obo_namespace: biological_process
id: GO:0042327

Axiom
annotated source: positive regulation of phosphorylation
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.
database_cross_reference: GOC:jl

taxis
type: Class
subclass of: locomotion
subclass of: Restriction
  on property: part of
  some values from: response to external stimulus
definition: The directed movement of a motile cell or organism in response to an external stimulus.
database_cross_reference: Wikipedia:Taxis
has_exact_synonym: directed movement in response to stimulus
has_obo_namespace: biological_process
id: GO:0042330

Axiom
annotated source: taxis
annotated property: definition
annotated target: The directed movement of a motile cell or organism in response to an external stimulus.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0192801023

phototaxis
type: Class
subclass of: response to light stimulus
subclass of: energy taxis
definition: The directed movement of a motile cell or organism in response to light.
has_alternative_id: GO:0046953
database_cross_reference: Wikipedia:Phototaxis
has_exact_synonym: phototactic behavior
has_exact_synonym: phototactic behaviour
has_exact_synonym: taxis in response to light
has_obo_namespace: biological_process
id: GO:0042331

Axiom
annotated source: phototaxis
annotated property: definition
annotated target: The directed movement of a motile cell or organism in response to light.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0192800981

vitamin E metabolic process
type: Class
subclass of: fat-soluble vitamin metabolic process
subclass of: heterocycle metabolic process
subclass of: GO_1901360
subclass of: GO_1901615
definition: The chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant.
has_exact_synonym: tocopherol metabolic process
has_exact_synonym: tocopherol metabolism
has_exact_synonym: vitamin E metabolism
has_narrow_synonym: alpha-tocopherol metabolic process
has_narrow_synonym: alpha-tocopherol metabolism
has_obo_namespace: biological_process
id: GO:0042360

Axiom
annotated source: vitamin E metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732

purine nucleoside biosynthetic process
type: Class
subclass of: nucleoside biosynthetic process
subclass of: purine nucleoside metabolic process
subclass of: GO_0072522
definition: The chemical reactions and pathways resulting in the formation of any purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).
has_exact_synonym: purine nucleoside anabolism
has_exact_synonym: purine nucleoside biosynthesis
has_exact_synonym: purine nucleoside formation
has_exact_synonym: purine nucleoside synthesis
has_obo_namespace: biological_process
id: GO:0042451

Axiom
annotated source: purine nucleoside biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of any purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).
database_cross_reference: GOC:go_curators

ribonucleoside biosynthetic process
type: Class
subclass of: ribonucleoside metabolic process
subclass of: nucleoside biosynthetic process
definition: The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule.
has_exact_synonym: ribonucleoside anabolism
has_exact_synonym: ribonucleoside biosynthesis
has_exact_synonym: ribonucleoside formation
has_exact_synonym: ribonucleoside synthesis
has_obo_namespace: biological_process
id: GO:0042455

Axiom
annotated source: ribonucleoside biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule.
database_cross_reference: GOC:jl

odontogenesis
type: Class
subclass of: animal organ morphogenesis
definition: The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food.
never in taxon: NCBITaxon 8782
has_alternative_id: GO:0042477
database_cross_reference: Wikipedia:Odontogenesis
has_exact_synonym: odontogeny
has_exact_synonym: odontosis
has_exact_synonym: tooth morphogenesis
has_narrow_synonym: odontogenesis of calcareous or chitinous tooth
has_obo_namespace: biological_process
has_related_synonym: tooth development
id: GO:0042476

Axiom
annotated source: odontogenesis
annotated property: definition
annotated target: The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

regulation of odontogenesis
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: odontogenesis
subclass of: GO_2000027
subclass of: Restriction
  on property: regulates
  some values from: odontogenesis
definition: Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth.
has_alternative_id: GO:0042484
has_exact_synonym: regulation of tooth development
has_narrow_synonym: regulation of odontogenesis of calcareous or chitinous tooth
has_obo_namespace: biological_process
id: GO:0042481

Axiom
annotated source: regulation of odontogenesis
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth.
database_cross_reference: GOC:jl

positive regulation of odontogenesis
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: odontogenesis
subclass of: regulation of odontogenesis
subclass of: GO_0110110
subclass of: Restriction
  on property: positively regulates
  some values from: odontogenesis
definition: Any process that activates or increases the frequency, rate or extent of the formation and development of a tooth or teeth.
has_alternative_id: GO:0042485
has_exact_synonym: positive regulation of tooth development
has_exact_synonym: up regulation of odontogenesis
has_exact_synonym: up-regulation of odontogenesis
has_exact_synonym: upregulation of odontogenesis
has_narrow_synonym: activation of odontogenesis
has_narrow_synonym: positive regulation of odontogenesis of calcareous or chitinous tooth
has_narrow_synonym: stimulation of odontogenesis
has_obo_namespace: biological_process
id: GO:0042482

Axiom
annotated source: positive regulation of odontogenesis
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of the formation and development of a tooth or teeth.
database_cross_reference: GOC:jl

negative regulation of odontogenesis
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: odontogenesis
subclass of: regulation of odontogenesis
subclass of: GO_0110111
subclass of: Restriction
  on property: negatively regulates
  some values from: odontogenesis
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of a tooth or teeth.
has_alternative_id: GO:0042486
has_exact_synonym: down regulation of odontogenesis
has_exact_synonym: down-regulation of odontogenesis
has_exact_synonym: downregulation of odontogenesis
has_exact_synonym: negative regulation of tooth development
has_narrow_synonym: inhibition of odontogenesis
has_narrow_synonym: negative regulation of odontogenesis of calcareous or chitinous tooth
has_obo_namespace: biological_process
id: GO:0042483

Axiom
annotated source: negative regulation of odontogenesis
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of a tooth or teeth.
database_cross_reference: GOC:jl

response to drug
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
has_alternative_id: GO:0017035
has_obo_namespace: biological_process
has_related_synonym: drug resistance
has_related_synonym: drug susceptibility/resistance
id: GO:0042493
in_subset: goslim candida

Axiom
annotated source: response to drug
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
database_cross_reference: GOC:jl

hyperosmotic salinity response
type: Class
subclass of: hyperosmotic response
subclass of: response to salt stress
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
has_exact_synonym: response to hyperosmotic salt stress
has_obo_namespace: biological_process
has_related_synonym: salt tolerance
id: GO:0042538

Axiom
annotated source: hyperosmotic salinity response
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
database_cross_reference: GOC:jl

neuron maturation
type: Class
subclass of: cell maturation
subclass of: Restriction
  on property: part of
  some values from: neuron development
definition: A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state.
has_obo_namespace: biological_process
id: GO:0042551

Axiom
annotated source: neuron maturation
annotated property: definition
annotated target: A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl

pteridine-containing compound metabolic process
type: Class
subclass of: cellular aromatic compound metabolic process
subclass of: heterocycle metabolic process
subclass of: GO_1901360
subclass of: GO_1901564
definition: The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid.
has_alternative_id: GO:0019721
has_exact_synonym: pteridine and derivative metabolic process
has_exact_synonym: pteridine and derivative metabolism
has_exact_synonym: pteridine-containing compound metabolism
has_narrow_synonym: pterin metabolic process
has_narrow_synonym: pterin metabolism
has_obo_namespace: biological_process
id: GO:0042558

Axiom
annotated source: pteridine-containing compound metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732

homeostatic process
type: Class
subclass of: GO_0065008
definition: Any biological process involved in the maintenance of an internal steady state.
has_alternative_id: GO:0032844
has_alternative_id: GO:0032845
has_alternative_id: GO:0032846
has_exact_synonym: homeostasis
has_narrow_synonym: activation of homeostatic process
has_narrow_synonym: inhibition of homeostatic process
has_obo_namespace: biological_process
has_related_synonym: negative regulation of homeostatic process
has_related_synonym: positive regulation of homeostatic process
has_related_synonym: regulation of homeostatic process
id: GO:0042592
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim mouse

Axiom
annotated source: homeostatic process
annotated property: definition
annotated target: Any biological process involved in the maintenance of an internal steady state.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0395825172

glucose homeostasis
type: Class
subclass of: carbohydrate homeostasis
definition: Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
has_obo_namespace: biological_process
id: GO:0042593

Axiom
annotated source: glucose homeostasis
annotated property: definition
annotated target: Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
database_cross_reference: GOC:go_curators

response to starvation
type: Class
subclass of: response to stress
subclass of: response to nutrient levels
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.
has_obo_namespace: biological_process
id: GO:0042594
in_subset: goslim yeast

Axiom
annotated source: response to starvation
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.
database_cross_reference: GOC:go_curators

behavioral response to water deprivation
type: Class
subclass of: behavior
subclass of: Restriction
  on property: part of
  some values from: response to water deprivation
definition: Any process that results in a change in the behavior of an organism as a result of deprivation of water.
has_exact_synonym: behavioral response to drought
has_exact_synonym: behavioral response to thirst
has_exact_synonym: behavioural response to water deprivation
has_obo_namespace: biological_process
id: GO:0042630

Axiom
annotated source: behavioral response to water deprivation
annotated property: definition
annotated target: Any process that results in a change in the behavior of an organism as a result of deprivation of water.
database_cross_reference: GOC:jl

chloroplast nucleoid
type: Class
equivalent class: Class
  intersection of: nucleoid
  intersection of: Restriction
    on property: part of
    some values from: chloroplast
subclass of: plastid nucleoid
subclass of: Restriction
  on property: part of
  some values from: chloroplast stroma
definition: The region of a chloroplast to which the DNA is confined.
has_obo_namespace: cellular_component
id: GO:0042644

Axiom
annotated source: chloroplast nucleoid
annotated property: definition
annotated target: The region of a chloroplast to which the DNA is confined.
database_cross_reference: GOC:jl

mitochondrial nucleoid
type: Class
equivalent class: Class
  intersection of: nucleoid
  intersection of: Restriction
    on property: part of
    some values from: mitochondrion
subclass of: nucleoid
subclass of: intracellular non-membrane-bounded organelle
subclass of: Restriction
  on property: part of
  some values from: mitochondrial matrix
definition: The region of a mitochondrion to which the DNA is confined.
has_obo_namespace: cellular_component
id: GO:0042645

Axiom
annotated source: mitochondrial nucleoid
annotated property: definition
annotated target: The region of a mitochondrion to which the DNA is confined.
database_cross_reference: GOC:jl

plastid nucleoid
type: Class
equivalent class: Class
  intersection of: nucleoid
  intersection of: Restriction
    on property: part of
    some values from: plastid
subclass of: nucleoid
subclass of: intracellular non-membrane-bounded organelle
subclass of: Restriction
  on property: part of
  some values from: plastid stroma
definition: The region of a plastid to which the DNA is confined.
has_obo_namespace: cellular_component
id: GO:0042646

Axiom
annotated source: plastid nucleoid
annotated property: definition
annotated target: The region of a plastid to which the DNA is confined.
database_cross_reference: GOC:jl

proplastid nucleoid
type: Class
equivalent class: Class
  intersection of: nucleoid
  intersection of: Restriction
    on property: part of
    some values from: proplastid
subclass of: plastid nucleoid
subclass of: Restriction
  on property: part of
  some values from: proplastid stroma
definition: The region of a proplastid to which the DNA is confined.
has_obo_namespace: cellular_component
id: GO:0042647

Axiom
annotated source: proplastid nucleoid
annotated property: definition
annotated target: The region of a proplastid to which the DNA is confined.
database_cross_reference: GOC:jl

biofilm formation
type: Class
subclass of: GO_0098630
definition: A process in which planktonically growing microorganisms grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
IAO_0000233: https://github.com/geneontology/go-ontology/issues/17727
has_obo_namespace: biological_process
id: GO:0042710
in_subset: gocheck do not annotate
in_subset: gocheck do not manually annotate
in_subset: goslim candida
in_subset: goslim pir

Axiom
annotated source: biofilm formation
annotated property: definition
annotated target: A process in which planktonically growing microorganisms grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
database_cross_reference: GOC:di
database_cross_reference: PMID:11932229

thiamine-containing compound metabolic process
type: Class
subclass of: cellular aromatic compound metabolic process
subclass of: water-soluble vitamin metabolic process
subclass of: sulfur compound metabolic process
subclass of: drug metabolic process
subclass of: GO_0072527
definition: The chemical reactions and pathways involving thiamine (vitamin B1), and compounds derived from it.
has_exact_synonym: thiamin and derivative metabolic process
has_exact_synonym: thiamin and derivative metabolism
has_exact_synonym: thiamin-containing compound metabolic process
has_exact_synonym: thiamine and derivative metabolic process
has_exact_synonym: thiamine and derivative metabolism
has_exact_synonym: thiamine-containing compound metabolism
has_exact_synonym: vitamin B1 and derivative metabolic process
has_exact_synonym: vitamin B1 and derivative metabolism
has_obo_namespace: biological_process
id: GO:0042723

Axiom
annotated source: thiamine-containing compound metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving thiamine (vitamin B1), and compounds derived from it.
database_cross_reference: GOC:jl

circadian sleep/wake cycle
type: Class
subclass of: circadian behavior
definition: The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm.
has_obo_namespace: biological_process
id: GO:0042745

Axiom
annotated source: circadian sleep/wake cycle
annotated property: definition
annotated target: The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm.
database_cross_reference: GOC:jl
database_cross_reference: http://www.sleepquest.com

circadian sleep/wake cycle, REM sleep
type: Class
subclass of: circadian sleep/wake cycle process
subclass of: Restriction
  on property: part of
  some values from: GO_0050802
definition: A stage in the circadian sleep cycle during which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity.
has_obo_namespace: biological_process
id: GO:0042747

Axiom
annotated source: circadian sleep/wake cycle, REM sleep
annotated property: definition
annotated target: A stage in the circadian sleep cycle during which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0395825172

circadian sleep/wake cycle, non-REM sleep
type: Class
subclass of: circadian sleep/wake cycle process
subclass of: Restriction
  on property: part of
  some values from: GO_0050802
definition: All sleep stages in the circadian sleep/wake cycle other than REM sleep. These stages are characterized by a slowing of brain waves and other physiological functions.
has_obo_namespace: biological_process
id: GO:0042748

Axiom
annotated source: circadian sleep/wake cycle, non-REM sleep
annotated property: definition
annotated target: All sleep stages in the circadian sleep/wake cycle other than REM sleep. These stages are characterized by a slowing of brain waves and other physiological functions.
database_cross_reference: GOC:jl
database_cross_reference: http://www.sleepquest.com

regulation of circadian sleep/wake cycle
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: circadian sleep/wake cycle
subclass of: regulation of circadian rhythm
subclass of: GO_0050795
subclass of: GO_0051239
subclass of: Restriction
  on property: regulates
  some values from: circadian sleep/wake cycle
definition: Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle.
has_obo_namespace: biological_process
id: GO:0042749

Axiom
annotated source: regulation of circadian sleep/wake cycle
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle.
database_cross_reference: GOC:jl

regulation of circadian rhythm
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: circadian rhythm
subclass of: GO_0050789
subclass of: Restriction
  on property: regulates
  some values from: circadian rhythm
definition: Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
has_obo_namespace: biological_process
id: GO:0042752

Axiom
annotated source: regulation of circadian rhythm
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:tb

positive regulation of circadian rhythm
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: circadian rhythm
subclass of: regulation of circadian rhythm
subclass of: positive regulation of biological process
subclass of: Restriction
  on property: positively regulates
  some values from: circadian rhythm
definition: Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior.
has_exact_synonym: up regulation of circadian rhythm
has_exact_synonym: up-regulation of circadian rhythm
has_exact_synonym: upregulation of circadian rhythm
has_narrow_synonym: activation of circadian rhythm
has_narrow_synonym: stimulation of circadian rhythm
has_obo_namespace: biological_process
id: GO:0042753

Axiom
annotated source: positive regulation of circadian rhythm
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior.
database_cross_reference: GOC:go_curators

negative regulation of circadian rhythm
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: circadian rhythm
subclass of: regulation of circadian rhythm
subclass of: negative regulation of biological process
subclass of: Restriction
  on property: negatively regulates
  some values from: circadian rhythm
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior.
has_exact_synonym: down regulation of circadian rhythm
has_exact_synonym: down-regulation of circadian rhythm
has_exact_synonym: downregulation of circadian rhythm
has_narrow_synonym: inhibition of circadian rhythm
has_obo_namespace: biological_process
id: GO:0042754

Axiom
annotated source: negative regulation of circadian rhythm
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior.
database_cross_reference: GOC:go_curators

eating behavior
type: Class
subclass of: feeding behavior
definition: The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue.
has_exact_synonym: eating behaviour
has_obo_namespace: biological_process
id: GO:0042755

Axiom
annotated source: eating behavior
annotated property: definition
annotated target: The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue.
database_cross_reference: GOC:jl
database_cross_reference: GOC:pr
database_cross_reference: PMID:19361967

drinking behavior
type: Class
subclass of: feeding behavior
definition: The specific behavior of an organism relating to the intake of liquids, especially water.
has_exact_synonym: drinking behaviour
has_obo_namespace: biological_process
id: GO:0042756

Axiom
annotated source: drinking behavior
annotated property: definition
annotated target: The specific behavior of an organism relating to the intake of liquids, especially water.
database_cross_reference: GOC:curators
database_cross_reference: GOC:pr

regulation of sulfur metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: sulfur compound metabolic process
subclass of: regulation of cellular metabolic process
subclass of: Restriction
  on property: regulates
  some values from: sulfur compound metabolic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur.
has_exact_synonym: regulation of sulfur metabolism
has_exact_synonym: regulation of sulphur metabolic process
has_exact_synonym: regulation of sulphur metabolism
has_obo_namespace: biological_process
id: GO:0042762

Axiom
annotated source: regulation of sulfur metabolic process
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur.
database_cross_reference: GOC:go_curators

amide transport
type: Class
subclass of: GO_0071705
definition: The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has_obo_namespace: biological_process
id: GO:0042886
in_subset: goslim pir

Axiom
annotated source: amide transport
annotated property: definition
annotated target: The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732

amide transmembrane transporter activity
type: Class
subclass of: transmembrane transporter activity
subclass of: Restriction
  on property: part of
  some values from: amide transport
definition: Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other.
has_narrow_synonym: amine/amide/polyamine channel activity
has_obo_namespace: molecular_function
id: GO:0042887

Axiom
annotated source: amide transmembrane transporter activity
annotated property: definition
annotated target: Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732

xenobiotic transport
type: Class
subclass of: transport
definition: The directed movement of a xenobiotic, a compound foreign to living organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has_obo_namespace: biological_process
id: GO:0042908
in_subset: goslim pir

Axiom
annotated source: xenobiotic transport
annotated property: definition
annotated target: The directed movement of a xenobiotic, a compound foreign to living organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
database_cross_reference: GOC:go_curators

xenobiotic transmembrane transporter activity
type: Class
subclass of: transmembrane transporter activity
subclass of: Restriction
  on property: part of
  some values from: xenobiotic transport
definition: Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
has_alternative_id: GO:0015238
has_alternative_id: GO:0015239
has_alternative_id: GO:0015559
has_alternative_id: GO:0015564
has_alternative_id: GO:0090484
has_obo_namespace: molecular_function
has_related_synonym: drug transmembrane transporter activity
has_related_synonym: drug transporter activity
has_related_synonym: multidrug efflux pump activity
has_related_synonym: multidrug transporter activity
has_related_synonym: multidrug, alkane resistant pump activity
has_related_synonym: xenobiotic transporter activity
id: GO:0042910
in_subset: goslim metagenomics

Axiom
annotated source: xenobiotic transmembrane transporter activity
annotated property: definition
annotated target: Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
database_cross_reference: GOC:go_curators

regulation of apoptotic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: apoptotic process
subclass of: regulation of programmed cell death
subclass of: Restriction
  on property: regulates
  some values from: apoptotic process
definition: Any process that modulates the occurrence or rate of cell death by apoptotic process.
has_narrow_synonym: regulation of apoptosis
has_obo_namespace: biological_process
has_related_synonym: apoptosis regulator activity
id: GO:0042981
comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.

Axiom
annotated source: regulation of apoptotic process
annotated property: definition
annotated target: Any process that modulates the occurrence or rate of cell death by apoptotic process.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mtg_apoptosis

cell projection
type: Class
subclass of: obsolete cell part
subclass of: GO_0110165
definition: A prolongation or process extending from a cell, e.g. a flagellum or axon.
imported from: go.owl
has_broad_synonym: cell process
has_broad_synonym: cellular process
has_exact_synonym: cellular projection
has_obo_namespace: cellular_component
id: GO:0042995
in_subset: goslim agr
in_subset: goslim flybase ribbon
in_subset: goslim mouse
in_subset: goslim pir

Axiom
annotated source: cell projection
annotated property: definition
annotated target: A prolongation or process extending from a cell, e.g. a flagellum or axon.
database_cross_reference: GOC:jl
database_cross_reference: http://www.cogsci.princeton.edu/~wn/

neuron projection
type: Class
subclass of: GO_0120025
definition: A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
imported from: go.owl
database_cross_reference: NIF_Subcellular:sao867568886
has_exact_synonym: neuron process
has_exact_synonym: neuron protrusion
has_exact_synonym: neuronal cell projection
has_narrow_synonym: neurite
has_obo_namespace: cellular_component
has_related_synonym: nerve fiber
id: GO:0043005
in_subset: goslim pir

Axiom
annotated source: neuron projection
annotated property: definition
annotated target: A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
database_cross_reference: GOC:jl
database_cross_reference: http://www.cogsci.princeton.edu/~wn/

Axiom
annotated source: neuron projection
annotated property: has_exact_synonym
annotated target: neuron protrusion
database_cross_reference: NIF_Subcellular:sao250931889

Axiom
annotated source: neuron projection
annotated property: has_related_synonym
annotated target: nerve fiber
database_cross_reference: GOC:dph

regulation of macrophage activation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: macrophage activation
subclass of: regulation of leukocyte activation
subclass of: Restriction
  on property: regulates
  some values from: macrophage activation
definition: Any process that modulates the frequency or rate of macrophage activation.
has_exact_synonym: regulation of macrophage polarization
has_obo_namespace: biological_process
id: GO:0043030

Axiom
annotated source: regulation of macrophage activation
annotated property: definition
annotated target: Any process that modulates the frequency or rate of macrophage activation.
database_cross_reference: GOC:jl

negative regulation of macrophage activation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: macrophage activation
subclass of: negative regulation of leukocyte activation
subclass of: regulation of macrophage activation
subclass of: Restriction
  on property: negatively regulates
  some values from: macrophage activation
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation.
has_exact_synonym: down regulation of macrophage activation
has_exact_synonym: down-regulation of macrophage activation
has_exact_synonym: downregulation of macrophage activation
has_exact_synonym: negative regulation of macrophage polarization
has_narrow_synonym: inhibition of macrophage activation
has_obo_namespace: biological_process
id: GO:0043031

Axiom
annotated source: negative regulation of macrophage activation
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation.
database_cross_reference: GOC:jl

positive regulation of macrophage activation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: macrophage activation
subclass of: positive regulation of leukocyte activation
subclass of: regulation of macrophage activation
subclass of: Restriction
  on property: positively regulates
  some values from: macrophage activation
definition: Any process that stimulates, induces or increases the rate of macrophage activation.
has_exact_synonym: positive regulation of macrophage polarization
has_exact_synonym: up regulation of macrophage activation
has_exact_synonym: up-regulation of macrophage activation
has_exact_synonym: upregulation of macrophage activation
has_narrow_synonym: activation of macrophage activation
has_narrow_synonym: stimulation of macrophage activation
has_obo_namespace: biological_process
id: GO:0043032

Axiom
annotated source: positive regulation of macrophage activation
annotated property: definition
annotated target: Any process that stimulates, induces or increases the rate of macrophage activation.
database_cross_reference: GOC:jl

DNA methylation involved in embryo development
type: Class
equivalent class: Class
  intersection of: DNA methylation
  intersection of: Restriction
    on property: part of
    some values from: embryo development
subclass of: DNA methylation
subclass of: GO_1901538
definition: The covalent transfer of a methyl group to C-5 of cytosine that contributes to the epigenetic regulation of embryonic gene expression.
has_obo_namespace: biological_process
has_related_synonym: de novo DNA methylation
id: GO:0043045

Axiom
annotated source: DNA methylation involved in embryo development
annotated property: definition
annotated target: The covalent transfer of a methyl group to C-5 of cytosine that contributes to the epigenetic regulation of embryonic gene expression.
database_cross_reference: GOC:go_curators
database_cross_reference: PMID:12138111

DNA methylation involved in gamete generation
type: Class
equivalent class: Class
  intersection of: DNA methylation
  intersection of: Restriction
    on property: part of
    some values from: gamete generation
subclass of: DNA methylation
subclass of: cellular process involved in reproduction in multicellular organism
subclass of: Restriction
  on property: part of
  some values from: gamete generation
definition: The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete.
has_obo_namespace: biological_process
has_related_synonym: de novo DNA methylation
id: GO:0043046

Axiom
annotated source: DNA methylation involved in gamete generation
annotated property: definition
annotated target: The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete.
database_cross_reference: GOC:go_curators
database_cross_reference: PMID:12138111

extracellular structure organization
type: Class
subclass of: cellular component organization
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite.
has_exact_synonym: extracellular structure organisation
has_exact_synonym: extracellular structure organization and biogenesis
has_obo_namespace: biological_process
id: GO:0043062
in_subset: goslim pir

Axiom
annotated source: extracellular structure organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite.
database_cross_reference: GOC:ai
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Axiom
annotated source: extracellular structure organization
annotated property: has_exact_synonym
annotated target: extracellular structure organization and biogenesis
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

positive regulation of apoptotic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: apoptotic process
subclass of: regulation of apoptotic process
subclass of: positive regulation of programmed cell death
subclass of: Restriction
  on property: positively regulates
  some values from: apoptotic process
definition: Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
has_exact_synonym: up regulation of apoptosis
has_exact_synonym: up-regulation of apoptosis
has_exact_synonym: upregulation of apoptosis
has_narrow_synonym: activation of apoptosis
has_narrow_synonym: positive regulation of apoptosis
has_narrow_synonym: stimulation of apoptosis
has_obo_namespace: biological_process
has_related_synonym: pro-apoptosis
id: GO:0043065
in_subset: goslim chembl
comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is positively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.

Axiom
annotated source: positive regulation of apoptotic process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mtg_apoptosis

negative regulation of apoptotic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: apoptotic process
subclass of: regulation of apoptotic process
subclass of: negative regulation of programmed cell death
subclass of: Restriction
  on property: negatively regulates
  some values from: apoptotic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
has_alternative_id: GO:0006916
has_exact_synonym: anti-apoptosis
has_exact_synonym: down regulation of apoptosis
has_exact_synonym: down-regulation of apoptosis
has_exact_synonym: downregulation of apoptosis
has_narrow_synonym: inhibition of apoptosis
has_narrow_synonym: negative regulation of apoptosis
has_obo_namespace: biological_process
has_related_synonym: apoptosis inhibitor activity
has_related_synonym: pro-survival
id: GO:0043066
comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is negatively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.

Axiom
annotated source: negative regulation of apoptotic process
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mtg_apoptosis

regulation of programmed cell death
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: programmed cell death
subclass of: regulation of cell death
subclass of: Restriction
  on property: regulates
  some values from: programmed cell death
definition: Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
has_alternative_id: GO:0043070
has_narrow_synonym: regulation of non-apoptotic programmed cell death
has_obo_namespace: biological_process
id: GO:0043067

Axiom
annotated source: regulation of programmed cell death
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
database_cross_reference: GOC:jl

positive regulation of programmed cell death
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: programmed cell death
subclass of: positive regulation of cell death
subclass of: regulation of programmed cell death
subclass of: Restriction
  on property: positively regulates
  some values from: programmed cell death
definition: Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
has_alternative_id: GO:0043071
has_exact_synonym: up regulation of programmed cell death
has_exact_synonym: up-regulation of programmed cell death
has_exact_synonym: upregulation of programmed cell death
has_narrow_synonym: activation of programmed cell death
has_narrow_synonym: positive regulation of non-apoptotic programmed cell death
has_narrow_synonym: stimulation of programmed cell death
has_obo_namespace: biological_process
id: GO:0043068

Axiom
annotated source: positive regulation of programmed cell death
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
database_cross_reference: GOC:jl

negative regulation of programmed cell death
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: programmed cell death
subclass of: regulation of programmed cell death
subclass of: GO_0060548
subclass of: Restriction
  on property: negatively regulates
  some values from: programmed cell death
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
has_alternative_id: GO:0043072
has_exact_synonym: down regulation of programmed cell death
has_exact_synonym: down-regulation of programmed cell death
has_exact_synonym: downregulation of programmed cell death
has_narrow_synonym: inhibition of programmed cell death
has_narrow_synonym: negative regulation of non-apoptotic programmed cell death
has_obo_namespace: biological_process
id: GO:0043069

Axiom
annotated source: negative regulation of programmed cell death
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
database_cross_reference: GOC:jl

positive regulation of catalytic activity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: catalytic activity
subclass of: positive regulation of molecular function
subclass of: GO_0050790
subclass of: Restriction
  on property: positively regulates
  some values from: catalytic activity
definition: Any process that activates or increases the activity of an enzyme.
has_alternative_id: GO:0048554
database_cross_reference: MIPS_funcat:18.02.01.01
has_exact_synonym: positive regulation of enzyme activity
has_exact_synonym: up regulation of enzyme activity
has_exact_synonym: up-regulation of enzyme activity
has_exact_synonym: upregulation of enzyme activity
has_narrow_synonym: activation of enzyme activity
has_narrow_synonym: activation of metalloenzyme activity
has_narrow_synonym: positive regulation of metalloenzyme activity
has_narrow_synonym: stimulation of enzyme activity
has_narrow_synonym: stimulation of metalloenzyme activity
has_narrow_synonym: up regulation of metalloenzyme activity
has_narrow_synonym: up-regulation of metalloenzyme activity
has_narrow_synonym: upregulation of metalloenzyme activity
has_obo_namespace: biological_process
id: GO:0043085
in_subset: goslim chembl

Axiom
annotated source: positive regulation of catalytic activity
annotated property: definition
annotated target: Any process that activates or increases the activity of an enzyme.
database_cross_reference: GOC:ebc
database_cross_reference: GOC:jl
database_cross_reference: GOC:tb
database_cross_reference: GOC:vw

Axiom
annotated source: positive regulation of catalytic activity
annotated property: has_exact_synonym
annotated target: positive regulation of enzyme activity
database_cross_reference: GOC:tb

negative regulation of catalytic activity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: catalytic activity
subclass of: negative regulation of molecular function
subclass of: GO_0050790
subclass of: Restriction
  on property: negatively regulates
  some values from: catalytic activity
definition: Any process that stops or reduces the activity of an enzyme.
has_alternative_id: GO:0048553
has_exact_synonym: down regulation of enzyme activity
has_exact_synonym: down-regulation of enzyme activity
has_exact_synonym: down-regulation of metalloenzyme activity
has_exact_synonym: downregulation of enzyme activity
has_exact_synonym: negative regulation of enzyme activity
has_narrow_synonym: down regulation of metalloenzyme activity
has_narrow_synonym: downregulation of metalloenzyme activity
has_narrow_synonym: inhibition of enzyme activity
has_narrow_synonym: inhibition of metalloenzyme activity
has_narrow_synonym: negative regulation of metalloenzyme activity
has_obo_namespace: biological_process
id: GO:0043086

Axiom
annotated source: negative regulation of catalytic activity
annotated property: definition
annotated target: Any process that stops or reduces the activity of an enzyme.
database_cross_reference: GOC:ebc
database_cross_reference: GOC:jl
database_cross_reference: GOC:tb
database_cross_reference: GOC:vw

Axiom
annotated source: negative regulation of catalytic activity
annotated property: has_exact_synonym
annotated target: negative regulation of enzyme activity
database_cross_reference: GOC:tb

macromolecule metabolic process
type: Class
subclass of: GO_0071704
definition: The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
has_alternative_id: GO:0043283
has_alternative_id: GO:0044259
has_exact_synonym: biopolymer metabolic process
has_exact_synonym: macromolecule metabolism
has_exact_synonym: organismal macromolecule metabolism
has_narrow_synonym: multicellular organismal macromolecule metabolic process
has_obo_namespace: biological_process
id: GO:0043170
in_subset: goslim pir

Axiom
annotated source: macromolecule metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
database_cross_reference: GOC:mah

Axiom
annotated source: macromolecule metabolic process
annotated property: has_exact_synonym
annotated target: biopolymer metabolic process
database_cross_reference: GOC:mtg_chebi_dec09

response to external biotic stimulus
type: Class
subclass of: response to external stimulus
subclass of: response to biotic stimulus
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things.
has_obo_namespace: biological_process
id: GO:0043207

Axiom
annotated source: response to external biotic stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things.
database_cross_reference: GOC:go_curators

myelin sheath
type: Class
subclass of: GO_0110165
definition: An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
database_cross_reference: FMA:62983
database_cross_reference: NIF_Subcellular:sao593830697
database_cross_reference: Wikipedia:Myelin
has_narrow_synonym: Schwann cell myelin sheath
has_narrow_synonym: astrocyte sheath
has_narrow_synonym: oligodendrocyte myelin sheath
has_obo_namespace: cellular_component
id: GO:0043209

Axiom
annotated source: myelin sheath
annotated property: definition
annotated target: An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
database_cross_reference: GOC:cjm
database_cross_reference: GOC:jl
database_cross_reference: NIF_Subcellular:sao593830697
database_cross_reference: Wikipedia:Myelin

Axiom
annotated source: myelin sheath
annotated property: has_narrow_synonym
annotated target: astrocyte sheath
database_cross_reference: NIF_Subcellular:nlx_subcell_20090204

Axiom
annotated source: myelin sheath
annotated property: has_narrow_synonym
annotated target: oligodendrocyte myelin sheath
database_cross_reference: NIF_Subcellular:sao1279474730

organelle
type: Class
subclass of: GO_0110165
definition: Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
database_cross_reference: NIF_Subcellular:sao1539965131
database_cross_reference: Wikipedia:Organelle
has_obo_namespace: cellular_component
id: GO:0043226
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim pir

Axiom
annotated source: organelle
annotated property: definition
annotated target: Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
database_cross_reference: GOC:go_curators

membrane-bounded organelle
type: Class
subclass of: organelle
definition: Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
database_cross_reference: NIF_Subcellular:sao414196390
has_exact_synonym: membrane-enclosed organelle
has_obo_namespace: cellular_component
id: GO:0043227

Axiom
annotated source: membrane-bounded organelle
annotated property: definition
annotated target: Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
database_cross_reference: GOC:go_curators

non-membrane-bounded organelle
type: Class
subclass of: organelle
definition: Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.
database_cross_reference: NIF_Subcellular:sao1456184038
has_exact_synonym: non-membrane-enclosed organelle
has_obo_namespace: cellular_component
id: GO:0043228

Axiom
annotated source: non-membrane-bounded organelle
annotated property: definition
annotated target: Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.
database_cross_reference: GOC:go_curators

intracellular organelle
type: Class
equivalent class: Class
  intersection of: organelle
  intersection of: Restriction
    on property: part of
    some values from: intracellular
subclass of: organelle
subclass of: Restriction
  on property: part of
  some values from: intracellular
definition: Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
has_obo_namespace: cellular_component
id: GO:0043229
in_subset: goslim pir

Axiom
annotated source: intracellular organelle
annotated property: definition
annotated target: Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
database_cross_reference: GOC:go_curators

extracellular organelle
type: Class
equivalent class: Class
  intersection of: organelle
  intersection of: Restriction
    on property: part of
    some values from: extracellular region
subclass of: organelle
subclass of: Restriction
  on property: part of
  some values from: extracellular region
definition: Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi.
has_obo_namespace: cellular_component
id: GO:0043230
in_subset: goslim pir

Axiom
annotated source: extracellular organelle
annotated property: definition
annotated target: Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi.
database_cross_reference: GOC:jl
database_cross_reference: PMID:9914479

intracellular membrane-bounded organelle
type: Class
subclass of: membrane-bounded organelle
subclass of: intracellular organelle
definition: Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
has_exact_synonym: intracellular membrane-enclosed organelle
has_obo_namespace: cellular_component
id: GO:0043231
in_subset: goslim pir

Axiom
annotated source: intracellular membrane-bounded organelle
annotated property: definition
annotated target: Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
database_cross_reference: GOC:go_curators

intracellular non-membrane-bounded organelle
type: Class
equivalent class: Class
  intersection of: non-membrane-bounded organelle
  intersection of: Restriction
    on property: part of
    some values from: intracellular
subclass of: non-membrane-bounded organelle
subclass of: intracellular organelle
definition: Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
has_exact_synonym: intracellular non-membrane-enclosed organelle
has_obo_namespace: cellular_component
id: GO:0043232
in_subset: goslim mouse
in_subset: goslim pir

Axiom
annotated source: intracellular non-membrane-bounded organelle
annotated property: definition
annotated target: Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
database_cross_reference: GOC:go_curators

organelle lumen
type: Class
equivalent class: Class
  intersection of: membrane-enclosed lumen
  intersection of: Restriction
    on property: part of
    some values from: organelle
subclass of: membrane-enclosed lumen
subclass of: Restriction
  on property: part of
  some values from: organelle
definition: The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.
has_obo_namespace: cellular_component
id: GO:0043233

Axiom
annotated source: organelle lumen
annotated property: definition
annotated target: The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

regulation of protein-containing complex assembly
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: GO_0065003
subclass of: regulation of cellular component biogenesis
subclass of: GO_0051128
subclass of: Restriction
  on property: regulates
  some values from: GO_0065003
definition: Any process that modulates the frequency, rate or extent of protein complex assembly.
has_obo_namespace: biological_process
has_related_synonym: regulation of protein complex assembly
id: GO:0043254

Axiom
annotated source: regulation of protein-containing complex assembly
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of protein complex assembly.
database_cross_reference: GOC:jl

regulation of ion transport
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: ion transport
subclass of: GO_0051049
subclass of: Restriction
  on property: regulates
  some values from: ion transport
definition: Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has_obo_namespace: biological_process
id: GO:0043269

Axiom
annotated source: regulation of ion transport
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
database_cross_reference: GOC:jl

positive regulation of ion transport
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: ion transport
subclass of: regulation of ion transport
subclass of: GO_0051050
subclass of: Restriction
  on property: positively regulates
  some values from: ion transport
definition: Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has_exact_synonym: up regulation of ion transport
has_exact_synonym: up-regulation of ion transport
has_exact_synonym: upregulation of ion transport
has_narrow_synonym: activation of ion transport
has_narrow_synonym: stimulation of ion transport
has_obo_namespace: biological_process
id: GO:0043270

Axiom
annotated source: positive regulation of ion transport
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
database_cross_reference: GOC:jl

negative regulation of ion transport
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: ion transport
subclass of: regulation of ion transport
subclass of: GO_0051051
subclass of: Restriction
  on property: negatively regulates
  some values from: ion transport
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has_exact_synonym: down regulation of ion transport
has_exact_synonym: down-regulation of ion transport
has_exact_synonym: downregulation of ion transport
has_narrow_synonym: inhibition of ion transport
has_obo_namespace: biological_process
id: GO:0043271

Axiom
annotated source: negative regulation of ion transport
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
database_cross_reference: GOC:jl

response to morphine
type: Class
subclass of: response to xenobiotic stimulus
subclass of: response to isoquinoline alkaloid
subclass of: GO_0072347
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure.
has_obo_namespace: biological_process
id: GO:0043278

Axiom
annotated source: response to morphine
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure.
database_cross_reference: GOC:ef
database_cross_reference: GOC:jl

response to alkaloid
type: Class
subclass of: response to organonitrogen compound
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active.
has_obo_namespace: biological_process
id: GO:0043279

Axiom
annotated source: response to alkaloid
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active.
database_cross_reference: GOC:jl

positive regulation of DNA binding
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: DNA binding
subclass of: GO_0051099
subclass of: GO_0051101
subclass of: Restriction
  on property: positively regulates
  some values from: DNA binding
definition: Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
has_exact_synonym: up regulation of DNA binding
has_exact_synonym: up-regulation of DNA binding
has_exact_synonym: upregulation of DNA binding
has_narrow_synonym: activation of DNA binding
has_narrow_synonym: stimulation of DNA binding
has_obo_namespace: biological_process
id: GO:0043388

Axiom
annotated source: positive regulation of DNA binding
annotated property: definition
annotated target: Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:tb

negative regulation of DNA binding
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: DNA binding
subclass of: GO_0051100
subclass of: GO_0051101
subclass of: Restriction
  on property: negatively regulates
  some values from: DNA binding
definition: Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
has_exact_synonym: down regulation of DNA binding
has_exact_synonym: down-regulation of DNA binding
has_exact_synonym: downregulation of DNA binding
has_narrow_synonym: inhibition of DNA binding
has_obo_namespace: biological_process
id: GO:0043392

Axiom
annotated source: negative regulation of DNA binding
annotated property: definition
annotated target: Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:tb

regulation of protein binding
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: protein binding
subclass of: GO_0051098
subclass of: Restriction
  on property: regulates
  some values from: protein binding
definition: Any process that modulates the frequency, rate or extent of protein binding.
has_obo_namespace: biological_process
id: GO:0043393

Axiom
annotated source: regulation of protein binding
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of protein binding.
database_cross_reference: GOC:go_curators

steroid hormone mediated signaling pathway
type: Class
subclass of: hormone-mediated signaling pathway
subclass of: Restriction
  on property: part of
  some values from: GO_0071383
definition: A series of molecular signals mediated by a steroid hormone binding to a receptor.
has_exact_synonym: steroid hormone mediated signalling
has_obo_namespace: biological_process
id: GO:0043401

Axiom
annotated source: steroid hormone mediated signaling pathway
annotated property: definition
annotated target: A series of molecular signals mediated by a steroid hormone binding to a receptor.
database_cross_reference: PMID:12606724

macromolecule modification
type: Class
subclass of: macromolecule metabolic process
definition: The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties.
has_obo_namespace: biological_process
id: GO:0043412
in_subset: goslim pir

Axiom
annotated source: macromolecule modification
annotated property: definition
annotated target: The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties.
database_cross_reference: GOC:go_curators

macromolecule glycosylation
type: Class
subclass of: macromolecule modification
subclass of: GO_0070085
definition: The covalent attachment of a glycosyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule.
has_obo_namespace: biological_process
id: GO:0043413

Axiom
annotated source: macromolecule glycosylation
annotated property: definition
annotated target: The covalent attachment of a glycosyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule.
database_cross_reference: GOC:jl

macromolecule methylation
type: Class
subclass of: methylation
subclass of: macromolecule modification
subclass of: cellular macromolecule metabolic process
definition: The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule.
has_obo_namespace: biological_process
id: GO:0043414

Axiom
annotated source: macromolecule methylation
annotated property: definition
annotated target: The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule.
database_cross_reference: GOC:go_curators

oxoacid metabolic process
type: Class
subclass of: organic acid metabolic process
definition: The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
has_exact_synonym: keto acid metabolic process
has_exact_synonym: keto acid metabolism
has_exact_synonym: ketoacid metabolic process
has_exact_synonym: ketoacid metabolism
has_exact_synonym: oxo acid metabolic process
has_exact_synonym: oxo acid metabolism
has_exact_synonym: oxoacid metabolism
has_obo_namespace: biological_process
id: GO:0043436

Axiom
annotated source: oxoacid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
database_cross_reference: Wikipedia:Oxyacid

regulation of kinase activity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: kinase activity
subclass of: regulation of phosphorylation
subclass of: GO_0051338
subclass of: Restriction
  on property: regulates
  some values from: kinase activity
definition: Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
has_obo_namespace: biological_process
id: GO:0043549

Axiom
annotated source: regulation of kinase activity
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
database_cross_reference: GOC:bf

bacterial nucleoid
type: Class
subclass of: nucleoid
subclass of: intracellular non-membrane-bounded organelle
definition: The region of a bacterial cell to which the DNA is confined.
has_obo_namespace: cellular_component
id: GO:0043590

Axiom
annotated source: bacterial nucleoid
annotated property: definition
annotated target: The region of a bacterial cell to which the DNA is confined.
database_cross_reference: GOC:jl

cellular amide metabolic process
type: Class
subclass of: cellular nitrogen compound metabolic process
definition: The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells.
has_exact_synonym: amide metabolism
has_obo_namespace: biological_process
id: GO:0043603
in_subset: goslim pir

Axiom
annotated source: cellular amide metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells.
database_cross_reference: GOC:curators

regulation of transcription from RNA polymerase II promoter in response to stress
type: Class
subclass of: regulation of transcription by RNA polymerase II
subclass of: regulation of DNA-templated transcription in response to stress
definition: Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
has_obo_namespace: biological_process
id: GO:0043618

Axiom
annotated source: regulation of transcription from RNA polymerase II promoter in response to stress
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
database_cross_reference: GOC:jl

regulation of DNA-templated transcription in response to stress
type: Class
subclass of: regulation of transcription, DNA-templated
subclass of: cellular response to stress
definition: Modulation of the frequency, rate or extent of transcription from a DNA template as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
has_exact_synonym: regulation of DNA-dependent transcription in response to stress
has_obo_namespace: biological_process
id: GO:0043620

Axiom
annotated source: regulation of DNA-templated transcription in response to stress
annotated property: definition
annotated target: Modulation of the frequency, rate or extent of transcription from a DNA template as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
database_cross_reference: GOC:jl
database_cross_reference: GOC:txnOH

Axiom
annotated source: regulation of DNA-templated transcription in response to stress
annotated property: has_exact_synonym
annotated target: regulation of DNA-dependent transcription in response to stress
database_cross_reference: GOC:txnOH

dicarboxylic acid metabolic process
type: Class
subclass of: carboxylic acid metabolic process
definition: The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-).
has_exact_synonym: dicarboxylate metabolic process
has_exact_synonym: dicarboxylate metabolism
has_exact_synonym: dicarboxylic acid metabolism
has_obo_namespace: biological_process
id: GO:0043648

Axiom
annotated source: dicarboxylic acid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-).
database_cross_reference: ISBN:0198506732

host extracellular space
type: Class
subclass of: host cellular component
definition: The space within a host but external to the plasma membrane of host cells, e.g. within host bloodstream.
has_exact_synonym: extracellular space of host
has_exact_synonym: host extracellular space
has_obo_namespace: cellular_component
id: GO:0043655

Axiom
annotated source: host extracellular space
annotated property: definition
annotated target: The space within a host but external to the plasma membrane of host cells, e.g. within host bloodstream.
database_cross_reference: GOC:cc

host intracellular region
type: Class
subclass of: host cell part
definition: That space within the plasma membrane of a host cell.
has_exact_synonym: host intracellular
has_exact_synonym: intracellular region of host
has_obo_namespace: cellular_component
id: GO:0043656

Axiom
annotated source: host intracellular region
annotated property: definition
annotated target: That space within the plasma membrane of a host cell.
database_cross_reference: GOC:cc

host cell
type: Class
subclass of: host cellular component
definition: A cell within a host organism. Includes the host plasma membrane and any external encapsulating structures such as the host cell wall and cell envelope.
has_obo_namespace: cellular_component
id: GO:0043657

Axiom
annotated source: host cell
annotated property: definition
annotated target: A cell within a host organism. Includes the host plasma membrane and any external encapsulating structures such as the host cell wall and cell envelope.
database_cross_reference: GOC:jl

regulation of multi-organism process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: GO_0051704
subclass of: GO_0050789
subclass of: Restriction
  on property: regulates
  some values from: GO_0051704
definition: Any process that modulates the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species.
has_obo_namespace: biological_process
id: GO:0043900

Axiom
annotated source: regulation of multi-organism process
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species.
database_cross_reference: GOC:jl

negative regulation of multi-organism process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: GO_0051704
subclass of: regulation of multi-organism process
subclass of: negative regulation of biological process
subclass of: Restriction
  on property: negatively regulates
  some values from: GO_0051704
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species.
has_obo_namespace: biological_process
id: GO:0043901

Axiom
annotated source: negative regulation of multi-organism process
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species.
database_cross_reference: GOC:jl

positive regulation of multi-organism process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: GO_0051704
subclass of: regulation of multi-organism process
subclass of: positive regulation of biological process
subclass of: Restriction
  on property: positively regulates
  some values from: GO_0051704
definition: Any process that activates or increases the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species.
has_obo_namespace: biological_process
id: GO:0043902

Axiom
annotated source: positive regulation of multi-organism process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species.
database_cross_reference: GOC:jl

regulation of symbiosis, encompassing mutualism through parasitism
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: symbiosis, encompassing mutualism through parasitism
subclass of: regulation of multi-organism process
subclass of: Restriction
  on property: regulates
  some values from: symbiosis, encompassing mutualism through parasitism
definition: Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association.
has_obo_namespace: biological_process
id: GO:0043903

Axiom
annotated source: regulation of symbiosis, encompassing mutualism through parasitism
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association.
database_cross_reference: GOC:jl

protein-containing complex subunit organization
type: Class
subclass of: cellular component organization
definition: Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex.
created by: midori
creation date: 2010-09-08T10:01:42Z
has_alternative_id: GO:0034600
has_alternative_id: GO:0034621
has_alternative_id: GO:0071822
has_exact_synonym: protein complex subunit organisation
has_exact_synonym: protein complex subunit organization
has_obo_namespace: biological_process
has_related_synonym: cellular macromolecular complex organization
has_related_synonym: cellular macromolecular complex subunit organisation
has_related_synonym: cellular macromolecular complex subunit organization
has_related_synonym: macromolecular complex organization
has_related_synonym: macromolecular complex subunit organisation
has_related_synonym: macromolecular complex subunit organization
id: GO:0043933

Axiom
annotated source: protein-containing complex subunit organization
annotated property: definition
annotated target: Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex.
database_cross_reference: GOC:mah

Axiom
annotated source: protein-containing complex subunit organization
annotated property: has_exact_synonym
annotated target: protein complex subunit organisation
database_cross_reference: GOC:mah

positive regulation of catalytic activity in other organism involved in symbiotic interaction
type: Class
subclass of: GO_0052203
definition: Any process in which an organism activates, maintains or increases the frequency, rate or extent of enzyme activity in a second organism, where the two organisms are in a symbiotic interaction.
has_narrow_synonym: activation of enzyme activity in other organism
has_narrow_synonym: activation of enzyme activity in other organism during symbiotic interaction
has_obo_namespace: biological_process
has_related_synonym: positive regulation of catalytic activity in other organism during symbiotic interaction
has_related_synonym: up regulation of enzyme activity in other organism during symbiotic interaction
has_related_synonym: up-regulation of enzyme activity in other organism during symbiotic interaction
has_related_synonym: upregulation of enzyme activity in other organism during symbiotic interaction
id: GO:0043946

Axiom
annotated source: positive regulation of catalytic activity in other organism involved in symbiotic interaction
annotated property: definition
annotated target: Any process in which an organism activates, maintains or increases the frequency, rate or extent of enzyme activity in a second organism, where the two organisms are in a symbiotic interaction.
database_cross_reference: GOC:mtg_pamgo_17jul06
database_cross_reference: GOC:tb

Axiom
annotated source: positive regulation of catalytic activity in other organism involved in symbiotic interaction
annotated property: has_related_synonym
annotated target: positive regulation of catalytic activity in other organism during symbiotic interaction
database_cross_reference: GOC:dph

induction by symbiont of host catalytic activity
type: Class
equivalent class: Class
  intersection of: GO_0052055
  intersection of: Restriction
    on property: positively regulates
    some values from: catalytic activity
subclass of: positive regulation of catalytic activity
subclass of: positive regulation of catalytic activity in other organism involved in symbiotic interaction
subclass of: GO_0052148
definition: Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has_exact_synonym: positive regulation by symbiont of host catalytic activity
has_exact_synonym: positive regulation by symbiont of host enzyme activity
has_exact_synonym: up regulation by symbiont of host enzyme activity
has_exact_synonym: up-regulation by symbiont of host enzyme activity
has_exact_synonym: upregulation by symbiont of host enzyme activity
has_narrow_synonym: activation by symbiont of host enzyme activity
has_narrow_synonym: activation of host enzyme activity
has_obo_namespace: biological_process
id: GO:0043948

Axiom
annotated source: induction by symbiont of host catalytic activity
annotated property: definition
annotated target: Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction.
database_cross_reference: GOC:mtg_pamgo_17jul06

modulation by symbiont of host process
type: Class
subclass of: GO_0051701
subclass of: GO_0051817
definition: The process in which a symbiont organism effects a change in the structure or processes of its host organism.
IAO_0000233: https://github.com/geneontology/go-ontology/issues/18719
has_alternative_id: GO:0044004
has_alternative_id: GO:0044055
has_narrow_synonym: modulation by symbiont of host system process
has_narrow_synonym: regulation by symbiont of host system process
has_obo_namespace: biological_process
has_related_synonym: disruption by symbiont of host cell
has_related_synonym: modification by symbiont of host biological process
has_related_synonym: modification by symbiont of host morphology or physiology
id: GO:0044003

Axiom
annotated source: modulation by symbiont of host process
annotated property: definition
annotated target: The process in which a symbiont organism effects a change in the structure or processes of its host organism.
database_cross_reference: GOC:cc

GO_0044004
type: Class
IAO_0000231: IAO_0000227
term replaced by: modulation by symbiont of host process
deprecated: true

single-species biofilm formation
type: Class
subclass of: biofilm formation
subclass of: GO_0051703
definition: A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
IAO_0000233: https://github.com/geneontology/go-ontology/issues/18814
has_alternative_id: GO:0052000
has_broad_synonym: auto-aggregation
has_narrow_synonym: bfp-dependent aggregation
has_narrow_synonym: bundle-forming fimbriae-dependent aggregation
has_narrow_synonym: bundle-forming pili-dependent aggregation
has_narrow_synonym: tfp-dependent aggregation
has_narrow_synonym: type IV pili-dependent aggregation
has_obo_namespace: biological_process
id: GO:0044010

Axiom
annotated source: single-species biofilm formation
annotated property: definition
annotated target: A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
database_cross_reference: GOC:cc
database_cross_reference: GOC:di
database_cross_reference: GOC:tb

single-species biofilm formation on inanimate substrate
type: Class
subclass of: GO_0090609
definition: A process in which microorganisms of the same species attach to and grow on an inanimate surface such as a rock or pipe, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription.
has_obo_namespace: biological_process
id: GO:0044011

Axiom
annotated source: single-species biofilm formation on inanimate substrate
annotated property: definition
annotated target: A process in which microorganisms of the same species attach to and grow on an inanimate surface such as a rock or pipe, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription.
database_cross_reference: GOC:cc

regulation of DNA methylation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: DNA methylation
subclass of: GO_0051052
subclass of: Restriction
  on property: regulates
  some values from: DNA methylation
definition: Any process that modulates the frequency, rate or extent of the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine.
has_obo_namespace: biological_process
id: GO:0044030

Axiom
annotated source: regulation of DNA methylation
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine.
database_cross_reference: GOC:jl

obsolete interaction with host via substance released outside of symbiont
type: Class
definition: OBSOLETE. An interaction with the host organism mediated by a substance that is released by the other organism. This includes substances that are released via pathogen cell lysis.
has_exact_synonym: interaction with host via substance released outside of symbiont cells
has_obo_namespace: biological_process
id: GO:0044046
comment: This term was obsoleted because it conflates a process and the mechanism of secretion of the gene product mediating the process.
deprecated: true

Axiom
annotated source: obsolete interaction with host via substance released outside of symbiont
annotated property: definition
annotated target: OBSOLETE. An interaction with the host organism mediated by a substance that is released by the other organism. This includes substances that are released via pathogen cell lysis.
database_cross_reference: MITRE:tk

regulation of system process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: system process
subclass of: GO_0051239
subclass of: Restriction
  on property: regulates
  some values from: system process
definition: Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.
has_obo_namespace: biological_process
id: GO:0044057

Axiom
annotated source: regulation of system process
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.
database_cross_reference: GOC:jl

regulation of excretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: excretion
subclass of: regulation of system process
subclass of: GO_0051046
subclass of: Restriction
  on property: regulates
  some values from: excretion
definition: Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity.
has_obo_namespace: biological_process
id: GO:0044062

Axiom
annotated source: regulation of excretion
annotated property: definition
annotated target: Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity.
database_cross_reference: GOC:jl

modulation by symbiont of host nervous system process
type: Class
equivalent class: Class
  intersection of: modulation by symbiont of host process
  intersection of: Restriction
    on property: regulates
    some values from: GO_0050877
subclass of: regulation of nervous system process
subclass of: modulation by symbiont of host process
definition: The alteration by a symbiont organism of the functioning of a host neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system.
has_exact_synonym: modulation by symbiont of host neurological system process
has_exact_synonym: regulation by symbiont of host neurological system process
has_obo_namespace: biological_process
id: GO:0044063

Axiom
annotated source: modulation by symbiont of host nervous system process
annotated property: definition
annotated target: The alteration by a symbiont organism of the functioning of a host neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system.
database_cross_reference: MITRE:tk

modulation by symbiont of host cellular process
type: Class
equivalent class: Class
  intersection of: modulation by symbiont of host process
  intersection of: Restriction
    on property: regulates
    some values from: cellular process
subclass of: modulation by symbiont of host process
subclass of: GO_0050794
definition: Any process in which a symbiont organism modulates the frequency, rate or extent of a cellular process, any process that is carried out at the cellular level, but not necessarily restricted to a single cell, in its host organism.
has_exact_synonym: modulation of host cellular process by symbiont
has_exact_synonym: regulation by symbiont of host cellular process
has_exact_synonym: regulation of host cellular process by symbiont
has_obo_namespace: biological_process
id: GO:0044068

Axiom
annotated source: modulation by symbiont of host cellular process
annotated property: definition
annotated target: Any process in which a symbiont organism modulates the frequency, rate or extent of a cellular process, any process that is carried out at the cellular level, but not necessarily restricted to a single cell, in its host organism.
database_cross_reference: MITRE:tk

modulation by symbiont of host anion transport
type: Class
equivalent class: Class
  intersection of: modulation by symbiont of host cellular process
  intersection of: Restriction
    on property: regulates
    some values from: anion transport
subclass of: modulation by symbiont of host cellular process
subclass of: regulation of anion transport
definition: The process in which a symbiont organism modulates the anion transport, the directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, of its host organism.
has_exact_synonym: modification of host anion transport by symbiont
has_obo_namespace: biological_process
id: GO:0044069

Axiom
annotated source: modulation by symbiont of host anion transport
annotated property: definition
annotated target: The process in which a symbiont organism modulates the anion transport, the directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, of its host organism.
database_cross_reference: MITRE:tk

regulation of anion transport
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: anion transport
subclass of: regulation of ion transport
subclass of: Restriction
  on property: regulates
  some values from: anion transport
definition: Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has_obo_namespace: biological_process
id: GO:0044070

Axiom
annotated source: regulation of anion transport
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
database_cross_reference: GOC:jl

modulation by symbiont of host cell cycle
type: Class
equivalent class: Class
  intersection of: modulation by symbiont of host process
  intersection of: Restriction
    on property: regulates
    some values from: cell cycle process
subclass of: regulation of cell cycle process
subclass of: modulation by symbiont of host cellular process
definition: The process in which a symbiont organism effects a change in its host's cell cycle through direct interactions with the host cell macromolecular machinery.
has_exact_synonym: modification by symbiont of host cell cycle
has_exact_synonym: modulation of host cell cycle by symbiont
has_exact_synonym: regulation by symbiont of host cell cycle
has_obo_namespace: biological_process
id: GO:0044071

Axiom
annotated source: modulation by symbiont of host cell cycle
annotated property: definition
annotated target: The process in which a symbiont organism effects a change in its host's cell cycle through direct interactions with the host cell macromolecular machinery.
database_cross_reference: MITRE:tk

negative regulation by symbiont of host cell cycle
type: Class
equivalent class: Class
  intersection of: modulation by symbiont of host process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cell cycle process
subclass of: negative regulation of cell cycle process
subclass of: modulation by symbiont of host cell cycle
definition: The process in which a symbiont organism stops, prevents or reduces the rate or extent of its host's progression through its cell cycle via direct interactions with the host cell macromolecular machinery.
has_obo_namespace: biological_process
id: GO:0044072

Axiom
annotated source: negative regulation by symbiont of host cell cycle
annotated property: definition
annotated target: The process in which a symbiont organism stops, prevents or reduces the rate or extent of its host's progression through its cell cycle via direct interactions with the host cell macromolecular machinery.
database_cross_reference: MITRE:tk

cellular component biogenesis
type: Class
subclass of: GO_0071840
definition: A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component.
has_alternative_id: GO:0071843
has_exact_synonym: cellular component biogenesis at cellular level
has_obo_namespace: biological_process
id: GO:0044085
in_subset: goslim pir

Axiom
annotated source: cellular component biogenesis
annotated property: definition
annotated target: A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

regulation of cellular component biogenesis
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cellular component biogenesis
subclass of: GO_0050794
subclass of: Restriction
  on property: regulates
  some values from: cellular component biogenesis
definition: Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component.
has_obo_namespace: biological_process
id: GO:0044087

Axiom
annotated source: regulation of cellular component biogenesis
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component.
database_cross_reference: GOC:jl

regulation of vacuole organization
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: vacuole organization
subclass of: regulation of organelle organization
subclass of: Restriction
  on property: regulates
  some values from: vacuole organization
definition: Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.
has_exact_synonym: regulation of vacuole organisation
has_obo_namespace: biological_process
has_related_synonym: regulation of vacuole biogenesis
id: GO:0044088

Axiom
annotated source: regulation of vacuole organization
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Axiom
annotated source: regulation of vacuole organization
annotated property: has_exact_synonym
annotated target: regulation of vacuole organisation
database_cross_reference: GOC:mah

Axiom
annotated source: regulation of vacuole organization
annotated property: has_related_synonym
annotated target: regulation of vacuole biogenesis
database_cross_reference: GOC:mah

positive regulation of cellular component biogenesis
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: cellular component biogenesis
subclass of: regulation of cellular component biogenesis
subclass of: positive regulation of cellular process
subclass of: Restriction
  on property: positively regulates
  some values from: cellular component biogenesis
definition: Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component.
has_obo_namespace: biological_process
id: GO:0044089

Axiom
annotated source: positive regulation of cellular component biogenesis
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component.
database_cross_reference: GOC:jl

positive regulation of vacuole organization
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: vacuole organization
subclass of: positive regulation of organelle organization
subclass of: regulation of vacuole organization
subclass of: Restriction
  on property: positively regulates
  some values from: vacuole organization
definition: Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.
has_exact_synonym: positive regulation of vacuole organisation
has_obo_namespace: biological_process
has_related_synonym: positive regulation of vacuole biogenesis
id: GO:0044090

Axiom
annotated source: positive regulation of vacuole organization
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Axiom
annotated source: positive regulation of vacuole organization
annotated property: has_exact_synonym
annotated target: positive regulation of vacuole organisation
database_cross_reference: GOC:mah

Axiom
annotated source: positive regulation of vacuole organization
annotated property: has_related_synonym
annotated target: positive regulation of vacuole biogenesis
database_cross_reference: GOC:mah

negative regulation of molecular function
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: molecular_function
subclass of: GO_0065009
subclass of: Restriction
  on property: negatively regulates
  some values from: molecular_function
definition: Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
created by: jane
creation date: 2009-04-21T04:07:27Z
has_obo_namespace: biological_process
id: GO:0044092

Axiom
annotated source: negative regulation of molecular function
annotated property: definition
annotated target: Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
database_cross_reference: GO:jl

positive regulation of molecular function
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: molecular_function
subclass of: GO_0065009
subclass of: Restriction
  on property: positively regulates
  some values from: molecular_function
definition: Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
created by: jane
creation date: 2009-04-21T04:11:06Z
has_obo_namespace: biological_process
id: GO:0044093

Axiom
annotated source: positive regulation of molecular function
annotated property: definition
annotated target: Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
database_cross_reference: GO:jl

growth involved in symbiotic interaction
type: Class
subclass of: growth
subclass of: interspecies interaction between organisms
definition: The increase in size or mass of an organism occurring when the organism is in a symbiotic interaction.
created by: jane
creation date: 2009-07-30T02:22:33Z
has_alternative_id: GO:0044153
has_obo_namespace: biological_process
has_related_synonym: growth during symbiotic interaction
has_related_synonym: growth on or near surface of other organism during symbiotic interaction
has_related_synonym: growth on or near surface of other organism involved in symbiotic interaction
id: GO:0044110
comment: This term partially replaces the obsolete term 'growth or development during symbiotic interaction ; GO:0052171'. See also 'development during symbiotic interaction ; GO:0044111'.

Axiom
annotated source: growth involved in symbiotic interaction
annotated property: definition
annotated target: The increase in size or mass of an organism occurring when the organism is in a symbiotic interaction.
database_cross_reference: GO:jl
database_cross_reference: GOC:pamgo_curators

Axiom
annotated source: growth involved in symbiotic interaction
annotated property: has_related_synonym
annotated target: growth during symbiotic interaction
database_cross_reference: GOC:dph

Axiom
annotated source: growth involved in symbiotic interaction
annotated property: has_related_synonym
annotated target: growth on or near surface of other organism during symbiotic interaction
database_cross_reference: GOC:tb

development involved in symbiotic interaction
type: Class
equivalent class: Class
  intersection of: developmental process
  intersection of: Restriction
    on property: part of
    some values from: interspecies interaction between organisms
subclass of: developmental process
subclass of: GO_0051704
subclass of: Restriction
  on property: part of
  some values from: interspecies interaction between organisms
definition: The progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction.
created by: jane
creation date: 2009-07-30T02:26:46Z
has_alternative_id: GO:0044152
has_narrow_synonym: development on or near surface of other organism involved in symbiotic interaction
has_obo_namespace: biological_process
has_related_synonym: development during symbiotic interaction
has_related_synonym: development on or near surface of other organism during symbiotic interaction
id: GO:0044111
comment: This term partially replaces the obsolete term 'growth or development during symbiotic interaction ; GO:0052171'. See also 'growth during symbiotic interaction ; GO:0044110'.

Axiom
annotated source: development involved in symbiotic interaction
annotated property: definition
annotated target: The progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction.
database_cross_reference: GO:jl
database_cross_reference: GOC:pamgo_curators

Axiom
annotated source: development involved in symbiotic interaction
annotated property: has_related_synonym
annotated target: development during symbiotic interaction
database_cross_reference: gOC:dph

Axiom
annotated source: development involved in symbiotic interaction
annotated property: has_related_synonym
annotated target: development on or near surface of other organism during symbiotic interaction
database_cross_reference: GOC:dph

obsolete other organism
type: Class
definition: OBSOLETE. A secondary organism with which the first organism is interacting.
created by: jane
creation date: 2009-11-12T01:04:58Z
has_obo_namespace: cellular_component
id: GO:0044215
comment: This term was obsoleted because it represents an organism, which is outside the scope of GO.
deprecated: true

Axiom
annotated source: obsolete other organism
annotated property: definition
annotated target: OBSOLETE. A secondary organism with which the first organism is interacting.
database_cross_reference: GOC:jl

other organism cell
type: Class
subclass of: other organism part
definition: A cell of a secondary organism with which the first organism is interacting.
created by: jane
creation date: 2009-11-12T01:17:06Z
has_obo_namespace: cellular_component
id: GO:0044216

Axiom
annotated source: other organism cell
annotated property: definition
annotated target: A cell of a secondary organism with which the first organism is interacting.
database_cross_reference: GOC:jl

other organism part
type: Class
subclass of: cellular_component
definition: Any constituent part of a secondary organism with which the first organism is interacting.
created by: jane
creation date: 2009-11-12T01:18:21Z
has_obo_namespace: cellular_component
id: GO:0044217
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: other organism part
annotated property: definition
annotated target: Any constituent part of a secondary organism with which the first organism is interacting.
database_cross_reference: GOC:jl

cellular metabolic process
type: Class
subclass of: metabolic process
subclass of: cellular process
definition: The chemical reactions and pathways by which individual cells transform chemical substances.
has_exact_synonym: cellular metabolism
has_obo_namespace: biological_process
has_related_synonym: intermediary metabolism
id: GO:0044237

Axiom
annotated source: cellular metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways by which individual cells transform chemical substances.
database_cross_reference: GOC:go_curators

Axiom
annotated source: cellular metabolic process
annotated property: has_related_synonym
annotated target: intermediary metabolism
database_cross_reference: GOC:mah

primary metabolic process
type: Class
subclass of: metabolic process
definition: The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
has_exact_synonym: primary metabolism
has_obo_namespace: biological_process
id: GO:0044238
in_subset: goslim pir

Axiom
annotated source: primary metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
database_cross_reference: GOC:go_curators
database_cross_reference: http://www.metacyc.org

cellular catabolic process
type: Class
subclass of: catabolic process
subclass of: cellular metabolic process
definition: The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
has_exact_synonym: cellular breakdown
has_exact_synonym: cellular catabolism
has_exact_synonym: cellular degradation
has_obo_namespace: biological_process
id: GO:0044248

Axiom
annotated source: cellular catabolic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
database_cross_reference: GOC:jl

cellular biosynthetic process
type: Class
subclass of: biosynthetic process
subclass of: cellular metabolic process
definition: The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
has_exact_synonym: cellular anabolism
has_exact_synonym: cellular biosynthesis
has_exact_synonym: cellular formation
has_exact_synonym: cellular synthesis
has_obo_namespace: biological_process
id: GO:0044249

Axiom
annotated source: cellular biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
database_cross_reference: GOC:jl

cellular lipid metabolic process
type: Class
subclass of: lipid metabolic process
subclass of: cellular metabolic process
definition: The chemical reactions and pathways involving lipids, as carried out by individual cells.
has_exact_synonym: cellular lipid metabolism
has_obo_namespace: biological_process
id: GO:0044255
in_subset: goslim pir

Axiom
annotated source: cellular lipid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving lipids, as carried out by individual cells.
database_cross_reference: GOC:jl

cellular macromolecule metabolic process
type: Class
subclass of: macromolecule metabolic process
subclass of: cellular metabolic process
definition: The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.
has_alternative_id: GO:0034960
has_exact_synonym: cellular biopolymer metabolic process
has_exact_synonym: cellular macromolecule metabolism
has_obo_namespace: biological_process
id: GO:0044260

Axiom
annotated source: cellular macromolecule metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.
database_cross_reference: GOC:mah

Axiom
annotated source: cellular macromolecule metabolic process
annotated property: has_exact_synonym
annotated target: cellular biopolymer metabolic process
database_cross_reference: GOC:mtg_chebi_dec09

cellular protein metabolic process
type: Class
subclass of: protein metabolic process
subclass of: cellular macromolecule metabolic process
definition: The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
has_exact_synonym: cellular protein metabolism
has_obo_namespace: biological_process
id: GO:0044267

Axiom
annotated source: cellular protein metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
database_cross_reference: GOC:jl

cellular nitrogen compound biosynthetic process
type: Class
subclass of: cellular nitrogen compound metabolic process
subclass of: cellular biosynthetic process
definition: The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds.
has_broad_synonym: nitrogen compound anabolism
has_broad_synonym: nitrogen compound biosynthesis
has_broad_synonym: nitrogen compound formation
has_broad_synonym: nitrogen compound synthesis
has_obo_namespace: biological_process
id: GO:0044271

Axiom
annotated source: cellular nitrogen compound biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732

small molecule metabolic process
type: Class
subclass of: metabolic process
definition: The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.
created by: jane
creation date: 2010-01-26T12:05:20Z
has_exact_synonym: small molecule metabolism
has_obo_namespace: biological_process
id: GO:0044281
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.

Axiom
annotated source: small molecule metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.
database_cross_reference: GOC:curators
database_cross_reference: GOC:pde
database_cross_reference: GOC:vw

small molecule biosynthetic process
type: Class
subclass of: biosynthetic process
subclass of: small molecule metabolic process
definition: The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule.
created by: jane
creation date: 2010-01-26T12:06:49Z
has_exact_synonym: small molecule biosynthesis
has_obo_namespace: biological_process
id: GO:0044283
comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.

Axiom
annotated source: small molecule biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule.
database_cross_reference: GOC:curators
database_cross_reference: GOC:pde
database_cross_reference: GOC:vw

modulation of molecular function in other organism
type: Class
subclass of: modulation of process of other organism
definition: The process in which an organism effects a change in the function of proteins in a second organism.
created by: janelomax
creation date: 2011-10-27T01:28:16Z
has_obo_namespace: biological_process
id: GO:0044359

Axiom
annotated source: modulation of molecular function in other organism
annotated property: definition
annotated target: The process in which an organism effects a change in the function of proteins in a second organism.
database_cross_reference: GOC:jl

negative regulation of molecular function in other organism
type: Class
subclass of: negative regulation of molecular function
subclass of: modulation of molecular function in other organism
definition: Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the function of proteins in a second organism.
created by: janelomax
creation date: 2011-10-27T02:12:49Z
has_obo_namespace: biological_process
id: GO:0044362

Axiom
annotated source: negative regulation of molecular function in other organism
annotated property: definition
annotated target: Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the function of proteins in a second organism.
database_cross_reference: GOC:jl

disruption of cells of other organism
type: Class
subclass of: modulation of process of other organism
definition: A process in which an organism has a negative effect on the functioning of the second organism's cells.
created by: janelomax
creation date: 2011-10-27T02:27:48Z
has_obo_namespace: biological_process
id: GO:0044364

Axiom
annotated source: disruption of cells of other organism
annotated property: definition
annotated target: A process in which an organism has a negative effect on the functioning of the second organism's cells.
database_cross_reference: GOC:jl

symbiosis, encompassing mutualism through parasitism
type: Class
subclass of: interspecies interaction between organisms
subclass of: Restriction
  on property: is symbiosis
  has self: true
definition: A process carried out by gene products in an organism that enable the organism to engage in a symbiotic relationship, a more or less intimate association, with another organism. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. Microscopic symbionts are often referred to as endosymbionts.
IAO_0000233: https://github.com/geneontology/go-ontology/issues/14807
has_alternative_id: GO:0043298
has_alternative_id: GO:0044404
has_alternative_id: GO:0072519
has_alternative_id: GO:0085031
has_narrow_synonym: commensalism
has_narrow_synonym: host-pathogen interaction
has_narrow_synonym: parasitism
has_obo_namespace: biological_process
has_related_synonym: symbiosis
has_related_synonym: symbiosis, encompassing mutualism through parasitism
has_related_synonym: symbiotic interaction
has_related_synonym: symbiotic interaction between host and organism
has_related_synonym: symbiotic interaction between organisms
has_related_synonym: symbiotic interaction between species
id: GO:0044403
in_subset: goslim chembl
in_subset: goslim generic
label: symbiotic process

Axiom
annotated source: symbiosis, encompassing mutualism through parasitism
annotated property: definition
annotated target: A process carried out by gene products in an organism that enable the organism to engage in a symbiotic relationship, a more or less intimate association, with another organism. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. Microscopic symbionts are often referred to as endosymbionts.
database_cross_reference: GOC:cc
database_cross_reference: https://study.com/academy/lesson/symbiont-definition-lesson-quiz.html

interspecies interaction between organisms
type: Class
subclass of: GO_0051704
definition: Any process in which an organism has an effect on an organism of a different species.
never in taxon: NCBITaxon 4895
has_exact_synonym: interaction with another species
has_exact_synonym: interspecies interaction
has_exact_synonym: interspecies interaction with other organisms
has_obo_namespace: biological_process
id: GO:0044419
in_subset: goslim candida
in_subset: goslim pir

Axiom
annotated source: interspecies interaction between organisms
annotated property: definition
annotated target: Any process in which an organism has an effect on an organism of a different species.
database_cross_reference: GOC:cc

obsolete extracellular matrix component
type: Class
definition: OBSOLETE. Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants).
consider: GO:0031012
has_exact_synonym: extracellular matrix part
has_obo_namespace: cellular_component
id: GO:0044420
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
deprecated: true

Axiom
annotated source: obsolete extracellular matrix component
annotated property: definition
annotated target: OBSOLETE. Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants).
database_cross_reference: GOC:jl

obsolete extracellular region part
type: Class
definition: OBSOLETE. Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
consider: GO:0005576
database_cross_reference: NIF_Subcellular:sao9117790637
has_obo_namespace: cellular_component
has_related_synonym: extracellular structure
id: GO:0044421
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
deprecated: true

Axiom
annotated source: obsolete extracellular region part
annotated property: definition
annotated target: OBSOLETE. Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
database_cross_reference: GOC:jl

Axiom
annotated source: obsolete extracellular region part
annotated property: has_related_synonym
annotated target: extracellular structure
database_cross_reference: NIF_Subcellular:sao9117790637

obsolete organelle part
type: Class
definition: OBSOLETE. Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
consider: GO:0043226
has_obo_namespace: cellular_component
id: GO:0044422
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
deprecated: true

Axiom
annotated source: obsolete organelle part
annotated property: definition
annotated target: OBSOLETE. Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
database_cross_reference: GOC:jl

obsolete intracellular part
type: Class
definition: OBSOLETE. Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
consider: GO:0005622
has_obo_namespace: cellular_component
id: GO:0044424
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
deprecated: true

Axiom
annotated source: obsolete intracellular part
annotated property: definition
annotated target: OBSOLETE. Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
database_cross_reference: GOC:jl

obsolete membrane part
type: Class
definition: OBSOLETE. Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
consider: GO:0016020
has_obo_namespace: cellular_component
id: GO:0044425
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
deprecated: true

Axiom
annotated source: obsolete membrane part
annotated property: definition
annotated target: OBSOLETE. Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
database_cross_reference: GOC:jl

obsolete cell wall part
type: Class
definition: OBSOLETE. Any constituent part of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
consider: GO:0005618
has_obo_namespace: cellular_component
id: GO:0044426
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
deprecated: true

Axiom
annotated source: obsolete cell wall part
annotated property: definition
annotated target: OBSOLETE. Any constituent part of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
database_cross_reference: GOC:jl

obsolete nuclear part
type: Class
definition: OBSOLETE. Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.
consider: GO:0005634
database_cross_reference: NIF_Subcellular:sao1499850686
has_exact_synonym: nuclear subcomponent
has_exact_synonym: nucleus component
has_obo_namespace: cellular_component
id: GO:0044428
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
deprecated: true

Axiom
annotated source: obsolete nuclear part
annotated property: definition
annotated target: OBSOLETE. Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.
database_cross_reference: GOC:jl

Axiom
annotated source: obsolete nuclear part
annotated property: has_exact_synonym
annotated target: nuclear subcomponent
database_cross_reference: NIF_Subcellular:sao1499850686

obsolete mitochondrial part
type: Class
definition: OBSOLETE. Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
consider: GO:0005739
database_cross_reference: NIF_Subcellular:sao666410040
has_exact_synonym: mitochondrial subcomponent
has_exact_synonym: mitochondrion component
has_obo_namespace: cellular_component
id: GO:0044429
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
deprecated: true

Axiom
annotated source: obsolete mitochondrial part
annotated property: definition
annotated target: OBSOLETE. Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
database_cross_reference: GOC:jl

Axiom
annotated source: obsolete mitochondrial part
annotated property: has_exact_synonym
annotated target: mitochondrial subcomponent
database_cross_reference: NIF_Subcellular:sao666410040

obsolete cytoskeletal part
type: Class
definition: OBSOLETE. Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.
consider: GO:0005856
database_cross_reference: NIF_Subcellular:sao1635329413
has_exact_synonym: cytoskeletal element
has_exact_synonym: cytoskeleton component
has_obo_namespace: cellular_component
id: GO:0044430
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
deprecated: true

Axiom
annotated source: obsolete cytoskeletal part
annotated property: definition
annotated target: OBSOLETE. Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.
database_cross_reference: GOC:jl

Axiom
annotated source: obsolete cytoskeletal part
annotated property: has_exact_synonym
annotated target: cytoskeletal element
database_cross_reference: NIF_Subcellular:sao1635329413

obsolete Golgi apparatus part
type: Class
definition: OBSOLETE. Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack.
consider: GO:0005794
database_cross_reference: NIF_Subcellular:sao624292949
has_exact_synonym: Golgi component
has_exact_synonym: Golgi subcomponent
has_obo_namespace: cellular_component
id: GO:0044431
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
deprecated: true

Axiom
annotated source: obsolete Golgi apparatus part
annotated property: definition
annotated target: OBSOLETE. Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack.
database_cross_reference: GOC:jl

Axiom
annotated source: obsolete Golgi apparatus part
annotated property: has_exact_synonym
annotated target: Golgi subcomponent
database_cross_reference: NIF_Subcellular:sao624292949

obsolete endoplasmic reticulum part
type: Class
definition: OBSOLETE. Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.
consider: GO:0005783
has_exact_synonym: ER component
has_obo_namespace: cellular_component
id: GO:0044432
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
deprecated: true

Axiom
annotated source: obsolete endoplasmic reticulum part
annotated property: definition
annotated target: OBSOLETE. Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.
database_cross_reference: GOC:jl

obsolete cytoplasmic vesicle part
type: Class
definition: OBSOLETE. Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.
consider: GO:0031410
has_obo_namespace: cellular_component
id: GO:0044433
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
deprecated: true

Axiom
annotated source: obsolete cytoplasmic vesicle part
annotated property: definition
annotated target: OBSOLETE. Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.
database_cross_reference: GOC:jl

obsolete chloroplast part
type: Class
definition: OBSOLETE. Any constituent part of a chloroplast, a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
consider: GO:0009507
has_obo_namespace: cellular_component
id: GO:0044434
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
deprecated: true

Axiom
annotated source: obsolete chloroplast part
annotated property: definition
annotated target: OBSOLETE. Any constituent part of a chloroplast, a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
database_cross_reference: GOC:jl

obsolete plastid part
type: Class
definition: OBSOLETE. Any constituent part of a plastid, a member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.
consider: GO:0009536
has_obo_namespace: cellular_component
id: GO:0044435
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
deprecated: true

Axiom
annotated source: obsolete plastid part
annotated property: definition
annotated target: OBSOLETE. Any constituent part of a plastid, a member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.
database_cross_reference: GOC:jl

obsolete thylakoid part
type: Class
definition: OBSOLETE. Any constituent part of a thylakoid, a sac-like vesicle that bears the photosynthetic pigments in photosynthetic organisms.
consider: GO:0009579
has_obo_namespace: cellular_component
id: GO:0044436
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
deprecated: true

Axiom
annotated source: obsolete thylakoid part
annotated property: definition
annotated target: OBSOLETE. Any constituent part of a thylakoid, a sac-like vesicle that bears the photosynthetic pigments in photosynthetic organisms.
database_cross_reference: GOC:jl

obsolete vacuolar part
type: Class
definition: OBSOLETE. Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material.
consider: GO:0005773
has_exact_synonym: vacuole component
has_obo_namespace: cellular_component
id: GO:0044437
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
deprecated: true

Axiom
annotated source: obsolete vacuolar part
annotated property: definition
annotated target: OBSOLETE. Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material.
database_cross_reference: GOC:jl

obsolete ciliary part
type: Class
definition: OBSOLETE. Any constituent part of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
consider: GO:0005929
has_alternative_id: GO:0044442
has_exact_synonym: cilial part
has_exact_synonym: cilium part
has_exact_synonym: microtubule-based flagellum part
has_narrow_synonym: flagellar part
has_narrow_synonym: flagellum component
has_narrow_synonym: flagellum part
has_obo_namespace: cellular_component
id: GO:0044441
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. Also note that cilia and eukaryotic flagella are deemed to be equivalent.
deprecated: true

Axiom
annotated source: obsolete ciliary part
annotated property: definition
annotated target: OBSOLETE. Any constituent part of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
database_cross_reference: GOC:cilia
database_cross_reference: GOC:jl

obsolete cytoplasmic part
type: Class
definition: OBSOLETE. Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
consider: GO:0005737
has_exact_synonym: cytoplasm component
has_obo_namespace: cellular_component
id: GO:0044444
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
deprecated: true

Axiom
annotated source: obsolete cytoplasmic part
annotated property: definition
annotated target: OBSOLETE. Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
database_cross_reference: GOC:jl

obsolete cytosolic part
type: Class
definition: OBSOLETE. Any constituent part of cytosol, that part of the cytoplasm that does not contain membranous or particulate subcellular components.
consider: GO:0005829
has_exact_synonym: cytosol component
has_obo_namespace: cellular_component
id: GO:0044445
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
deprecated: true

Axiom
annotated source: obsolete cytosolic part
annotated property: definition
annotated target: OBSOLETE. Any constituent part of cytosol, that part of the cytoplasm that does not contain membranous or particulate subcellular components.
database_cross_reference: GOC:jl

obsolete intracellular organelle part
type: Class
definition: OBSOLETE. A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
consider: GO:0043229
has_obo_namespace: cellular_component
id: GO:0044446
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
deprecated: true

Axiom
annotated source: obsolete intracellular organelle part
annotated property: definition
annotated target: OBSOLETE. A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
database_cross_reference: GOC:jl

obsolete nucleolar part
type: Class
definition: OBSOLETE. Any constituent part of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis.
consider: GO:0005730
has_exact_synonym: nucleolus component
has_obo_namespace: cellular_component
id: GO:0044452
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
deprecated: true

Axiom
annotated source: obsolete nucleolar part
annotated property: definition
annotated target: OBSOLETE. Any constituent part of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis.
database_cross_reference: GOC:jl

obsolete synapse part
type: Class
subclass of: obsolete cell part
definition: OBSOLETE. Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
imported from: go.owl
consider: GO:0045202
database_cross_reference: NIF_Subcellular:sao1784069613
has_obo_namespace: cellular_component
has_related_synonym: synaptic component
id: GO:0044456
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
label: synapse part
deprecated: true

Axiom
annotated source: obsolete synapse part
annotated property: definition
annotated target: OBSOLETE. Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
database_cross_reference: GOC:jl

Axiom
annotated source: obsolete synapse part
annotated property: has_related_synonym
annotated target: synaptic component
database_cross_reference: NIF_Subcellular:sao1784069613

obsolete plasma membrane part
type: Class
definition: OBSOLETE. Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
consider: GO:0005886
has_obo_namespace: cellular_component
id: GO:0044459
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
deprecated: true

Axiom
annotated source: obsolete plasma membrane part
annotated property: definition
annotated target: OBSOLETE. Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
database_cross_reference: GOC:jl

obsolete external encapsulating structure part
type: Class
definition: OBSOLETE. Any constituent part of an external encapsulating structure, a structure that lies outside the plasma membrane and surrounds the entire cell. This does not include the periplasmic space but does include the outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria).
consider: GO:0030312
has_obo_namespace: cellular_component
id: GO:0044462
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
deprecated: true

Axiom
annotated source: obsolete external encapsulating structure part
annotated property: definition
annotated target: OBSOLETE. Any constituent part of an external encapsulating structure, a structure that lies outside the plasma membrane and surrounds the entire cell. This does not include the periplasmic space but does include the outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria).
database_cross_reference: GOC:jl

obsolete cell projection part
type: Class
definition: OBSOLETE. Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.
consider: GO:0042995
has_obo_namespace: cellular_component
id: GO:0044463
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
deprecated: true

Axiom
annotated source: obsolete cell projection part
annotated property: definition
annotated target: OBSOLETE. Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.
database_cross_reference: GOC:jl

obsolete cell part
type: Class
subclass of: cell part
definition: OBSOLETE. Any constituent part of a cell, the basic structural and functional unit of all organisms.
imported from: go.owl
consider: CL:0000000
database_cross_reference: NIF_Subcellular:sao628508602
has_exact_synonym: cellular subcomponent
has_obo_namespace: cellular_component
has_related_synonym: protoplast
id: GO:0044464
in_subset: gocheck do not annotate
in_subset: goslim pir
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
label: cell part
deprecated: true

Axiom
annotated source: obsolete cell part
annotated property: definition
annotated target: OBSOLETE. Any constituent part of a cell, the basic structural and functional unit of all organisms.
database_cross_reference: GOC:jl

Axiom
annotated source: obsolete cell part
annotated property: has_exact_synonym
annotated target: cellular subcomponent
database_cross_reference: NIF_Subcellular:sao628508602

Axiom
annotated source: obsolete cell part
annotated property: has_related_synonym
annotated target: protoplast
database_cross_reference: GOC:mah

modulation of programmed cell death in other organism
type: Class
subclass of: modulation of process of other organism
subclass of: regulation of programmed cell death
definition: A process in which an organism modulates the frequency, rate or extent of programmed cell death in a second organism.
created by: janelomax
creation date: 2012-03-20T04:48:41Z
has_obo_namespace: biological_process
id: GO:0044531

Axiom
annotated source: modulation of programmed cell death in other organism
annotated property: definition
annotated target: A process in which an organism modulates the frequency, rate or extent of programmed cell death in a second organism.
database_cross_reference: GOC:jl

modulation of apoptotic process in other organism
type: Class
subclass of: regulation of apoptotic process
subclass of: modulation of programmed cell death in other organism
definition: A process in which an organism modulates the frequency, rate or extent of apoptosis in a second organism.
created by: janelomax
creation date: 2012-03-21T11:17:18Z
has_exact_synonym: regulation of apoptotic process in other organism
has_obo_namespace: biological_process
id: GO:0044532

Axiom
annotated source: modulation of apoptotic process in other organism
annotated property: definition
annotated target: A process in which an organism modulates the frequency, rate or extent of apoptosis in a second organism.
database_cross_reference: GOC:jl

tooth eruption
type: Class
subclass of: anatomical structure development
subclass of: Restriction
  on property: part of
  some values from: odontogenesis
definition: The tooth development process in which the teeth enter the mouth and become visible.
created by: janelomax
creation date: 2012-08-15T14:58:17Z
database_cross_reference: Wikipedia:Tooth_eruption
has_obo_namespace: biological_process
id: GO:0044691

Axiom
annotated source: tooth eruption
annotated property: definition
annotated target: The tooth development process in which the teeth enter the mouth and become visible.
database_cross_reference: Wikipedia:Tooth_eruption

GO_0044699
type: Class
IAO_0000231: IAO_0000227
term replaced by: biological_process
deprecated: true

GO_0044700
type: Class
IAO_0000231: IAO_0000227
term replaced by: signaling
deprecated: true

multi-organism reproductive process
type: Class
subclass of: reproductive process
subclass of: GO_0051704
definition: A biological process that directly contributes to the process of producing new individuals, involving another organism.
created by: janelomax
creation date: 2012-09-19T15:56:30Z
has_obo_namespace: biological_process
id: GO:0044703

Axiom
annotated source: multi-organism reproductive process
annotated property: definition
annotated target: A biological process that directly contributes to the process of producing new individuals, involving another organism.
database_cross_reference: GOC:jl

multi-organism reproductive behavior
type: Class
subclass of: reproductive behavior
definition: The specific behavior of an organism that is associated with reproduction involving another organism of the same or different species.
created by: janelomax
creation date: 2012-09-19T16:02:12Z
has_obo_namespace: biological_process
id: GO:0044705

Axiom
annotated source: multi-organism reproductive behavior
annotated property: definition
annotated target: The specific behavior of an organism that is associated with reproduction involving another organism of the same or different species.
database_cross_reference: GOC:jl
database_cross_reference: GOC:pr

multi-multicellular organism process
type: Class
subclass of: multicellular organismal process
subclass of: GO_0051704
definition: A multicellular organism process which involves another multicellular organism of the same or different species.
created by: janelomax
creation date: 2012-09-19T16:06:16Z
has_obo_namespace: biological_process
id: GO:0044706

Axiom
annotated source: multi-multicellular organism process
annotated property: definition
annotated target: A multicellular organism process which involves another multicellular organism of the same or different species.
database_cross_reference: GOC:jl

GO_0044707
type: Class
IAO_0000231: IAO_0000227
term replaced by: multicellular organismal process
deprecated: true

GO_0044710
type: Class
IAO_0000231: IAO_0000227
term replaced by: metabolic process
deprecated: true

DNA methylation or demethylation
type: Class
subclass of: DNA modification
definition: The process of adding or removing a methyl group from one or more nucleotides within an DNA molecule.
created by: janelomax
creation date: 2012-10-24T14:49:41Z
has_obo_namespace: biological_process
has_related_synonym: changes in DNA methylation
id: GO:0044728

Axiom
annotated source: DNA methylation or demethylation
annotated property: definition
annotated target: The process of adding or removing a methyl group from one or more nucleotides within an DNA molecule.
database_cross_reference: GOC:jl

GO_0044763
type: Class
IAO_0000231: IAO_0000227
term replaced by: cellular process
deprecated: true

multi-organism cellular process
type: Class
subclass of: cellular process
subclass of: GO_0051704
definition: Any process that is carried out at the cellular level which involves another organism of the same or different species.
created by: janelomax
creation date: 2012-12-11T17:00:50Z
has_obo_namespace: biological_process
id: GO:0044764

Axiom
annotated source: multi-organism cellular process
annotated property: definition
annotated target: Any process that is carried out at the cellular level which involves another organism of the same or different species.
database_cross_reference: GOC:jl

GO_0044765
type: Class
IAO_0000231: IAO_0000227
term replaced by: transport
deprecated: true

multi-organism transport
type: Class
subclass of: transport
subclass of: GO_1902579
definition: The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving more than one organism.
created by: janelomax
creation date: 2012-12-13T16:25:50Z
has_obo_namespace: biological_process
id: GO:0044766

Axiom
annotated source: multi-organism transport
annotated property: definition
annotated target: The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving more than one organism.
database_cross_reference: GOC:jl

GO_0044767
type: Class
IAO_0000231: IAO_0000227
term replaced by: developmental process
deprecated: true

cilium organization
type: Class
subclass of: organelle organization
subclass of: GO_0120036
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
created by: janelomax
creation date: 2013-03-27T15:09:58Z
has_exact_synonym: microtubule-based flagellum organization
has_obo_namespace: biological_process
id: GO:0044782
in_subset: goslim drosophila
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.

Axiom
annotated source: cilium organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
database_cross_reference: GOC:cilia
database_cross_reference: GOC:jl

biological phase
type: Class
subclass of: biological_process
disjoint with: rhythmic process
disjoint with: GO_0050896
disjoint with: GO_0051179
disjoint with: GO_0051704
disjoint with: GO_0071840
disjoint with: GO_0098743
definition: A distinct period or stage in a biological process or cycle.
created by: janelomax
creation date: 2014-07-16T13:12:40Z
has_obo_namespace: biological_process
id: GO:0044848
in_subset: gocheck do not manually annotate
comment: Note that phases are is_a disjoint from other biological processes. happens_during relationships can operate between phases and other biological processes e.g. DNA replication happens_during S phase.

Axiom
annotated source: biological phase
annotated property: definition
annotated target: A distinct period or stage in a biological process or cycle.
database_cross_reference: GOC:jl

plasma membrane raft
type: Class
equivalent class: Class
  intersection of: membrane raft
  intersection of: Restriction
    on property: part of
    some values from: plasma membrane
subclass of: membrane raft
subclass of: GO_0098590
definition: A membrane raft that is part of the plasma membrane.
created by: janelomax
creation date: 2014-07-23T15:55:23Z
has_obo_namespace: cellular_component
id: GO:0044853

Axiom
annotated source: plasma membrane raft
annotated property: definition
annotated target: A membrane raft that is part of the plasma membrane.
database_cross_reference: GOC:jl

membrane raft
type: Class
subclass of: GO_0098857
definition: Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
database_cross_reference: Wikipedia:Lipid_raft
has_exact_synonym: lipid raft
has_obo_namespace: cellular_component
has_related_synonym: GEM domain
has_related_synonym: glycolipid-enriched membrane domain
id: GO:0045121

Axiom
annotated source: membrane raft
annotated property: definition
annotated target: Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
database_cross_reference: PMID:16645198
database_cross_reference: PMID:20044567

meiotic chromosome segregation
type: Class
equivalent class: Class
  intersection of: GO_0098813
  intersection of: Restriction
    on property: part of
    some values from: GO_0140013
subclass of: GO_0098813
subclass of: GO_1903046
subclass of: Restriction
  on property: part of
  some values from: GO_0140013
definition: The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle.
has_obo_namespace: biological_process
id: GO:0045132

Axiom
annotated source: meiotic chromosome segregation
annotated property: definition
annotated target: The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle.
database_cross_reference: GOC:ai
database_cross_reference: GOC:mah

meiotic sister chromatid segregation
type: Class
equivalent class: Class
  intersection of: sister chromatid segregation
  intersection of: Restriction
    on property: part of
    some values from: meiosis II
subclass of: sister chromatid segregation
subclass of: meiotic chromosome segregation
subclass of: GO_0070192
subclass of: Restriction
  on property: part of
  some values from: meiosis II
definition: The cell cycle process in which sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle.
has_exact_synonym: meiosis II, chromosome segregation
has_obo_namespace: biological_process
id: GO:0045144

Axiom
annotated source: meiotic sister chromatid segregation
annotated property: definition
annotated target: The cell cycle process in which sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle.
database_cross_reference: GOC:ai
database_cross_reference: ISBN:0815316194

neuronal ion channel clustering
type: Class
subclass of: GO_0061024
subclass of: Restriction
  on property: part of
  some values from: neuron maturation
definition: The process in which voltage-gated ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation.
has_obo_namespace: biological_process
id: GO:0045161

Axiom
annotated source: neuronal ion channel clustering
annotated property: definition
annotated target: The process in which voltage-gated ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation.
database_cross_reference: PMID:11456440

establishment of protein localization
type: Class
subclass of: protein localization
subclass of: GO_0051234
definition: The directed movement of a protein to a specific location.
has_exact_synonym: establishment of protein localisation
has_exact_synonym: protein positioning
has_exact_synonym: protein recruitment
has_obo_namespace: biological_process
id: GO:0045184

Axiom
annotated source: establishment of protein localization
annotated property: definition
annotated target: The directed movement of a protein to a specific location.
database_cross_reference: GOC:bf

Axiom
annotated source: establishment of protein localization
annotated property: has_exact_synonym
annotated target: establishment of protein localisation
database_cross_reference: GOC:mah

regulation of circadian sleep/wake cycle, sleep
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: GO_0050802
subclass of: regulation of circadian sleep/wake cycle
subclass of: Restriction
  on property: regulates
  some values from: GO_0050802
definition: Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.
has_exact_synonym: regulation of sleep
has_obo_namespace: biological_process
id: GO:0045187

Axiom
annotated source: regulation of circadian sleep/wake cycle, sleep
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0192800981

regulation of circadian sleep/wake cycle, non-REM sleep
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: circadian sleep/wake cycle, non-REM sleep
subclass of: regulation of circadian sleep/wake cycle, sleep
subclass of: Restriction
  on property: regulates
  some values from: circadian sleep/wake cycle, non-REM sleep
definition: Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep.
has_exact_synonym: regulation of non-REM sleep
has_obo_namespace: biological_process
id: GO:0045188

Axiom
annotated source: regulation of circadian sleep/wake cycle, non-REM sleep
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep.
database_cross_reference: GOC:go_curators

synapse
type: Class
subclass of: anatomical structure
subclass of: cell junction
definition: The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
imported from: go.owl
database_cross_reference: NIF_Subcellular:sao914572699
database_cross_reference: Wikipedia:Chemical_synapse
has_exact_synonym: synaptic junction
has_narrow_synonym: mixed synapse
has_obo_namespace: cellular_component
has_related_synonym: electrotonic synapse
id: GO:0045202
in_subset: goslim agr
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim synapse

Axiom
annotated source: synapse
annotated property: definition
annotated target: The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
database_cross_reference: GOC:aruk
database_cross_reference: ISBN:0198506732
database_cross_reference: PMID:24619342
database_cross_reference: PMID:29383328
database_cross_reference: PMID:31998110

Axiom
annotated source: synapse
annotated property: has_narrow_synonym
annotated target: mixed synapse
database_cross_reference: NIF_Subcellular:sao1506103497

Axiom
annotated source: synapse
annotated property: has_related_synonym
annotated target: electrotonic synapse
database_cross_reference: NIF_Subcellular:sao1311109124

leukocyte activation
type: Class
subclass of: cell activation
subclass of: immune system process
definition: A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor.
database_cross_reference: Wikipedia:Immunologic_activation
has_exact_synonym: immune cell activation
has_exact_synonym: leucocyte activation
has_obo_namespace: biological_process
id: GO:0045321

Axiom
annotated source: leukocyte activation
annotated property: definition
annotated target: A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor.
database_cross_reference: GOC:add

response to ether
type: Class
subclass of: response to organic substance
subclass of: GO_1901700
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus.
has_obo_namespace: biological_process
id: GO:0045472

Axiom
annotated source: response to ether
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus.
database_cross_reference: GOC:go_curators

locomotor rhythm
type: Class
subclass of: locomotory behavior
subclass of: circadian behavior
definition: The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.
has_narrow_synonym: circadian locomotor activity rhythm
has_obo_namespace: biological_process
id: GO:0045475

Axiom
annotated source: locomotor rhythm
annotated property: definition
annotated target: The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.
database_cross_reference: GOC:go_curators

regulation of cell differentiation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cell differentiation
subclass of: GO_0050793
subclass of: GO_0050794
subclass of: Restriction
  on property: regulates
  some values from: cell differentiation
definition: Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.
has_obo_namespace: biological_process
id: GO:0045595

Axiom
annotated source: regulation of cell differentiation
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.
database_cross_reference: GOC:go_curators

negative regulation of cell differentiation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cell differentiation
subclass of: regulation of cell differentiation
subclass of: negative regulation of cellular process
subclass of: GO_0051093
subclass of: Restriction
  on property: negatively regulates
  some values from: cell differentiation
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation.
has_exact_synonym: down regulation of cell differentiation
has_exact_synonym: down-regulation of cell differentiation
has_exact_synonym: downregulation of cell differentiation
has_narrow_synonym: inhibition of cell differentiation
has_obo_namespace: biological_process
id: GO:0045596

Axiom
annotated source: negative regulation of cell differentiation
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation.
database_cross_reference: GOC:go_curators

positive regulation of cell differentiation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: cell differentiation
subclass of: regulation of cell differentiation
subclass of: positive regulation of cellular process
subclass of: GO_0051094
subclass of: Restriction
  on property: positively regulates
  some values from: cell differentiation
definition: Any process that activates or increases the frequency, rate or extent of cell differentiation.
has_exact_synonym: up regulation of cell differentiation
has_exact_synonym: up-regulation of cell differentiation
has_exact_synonym: upregulation of cell differentiation
has_narrow_synonym: activation of cell differentiation
has_narrow_synonym: stimulation of cell differentiation
has_obo_namespace: biological_process
id: GO:0045597

Axiom
annotated source: positive regulation of cell differentiation
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of cell differentiation.
database_cross_reference: GOC:go_curators

regulation of myeloid cell differentiation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: myeloid cell differentiation
subclass of: regulation of cell differentiation
subclass of: GO_1903706
subclass of: Restriction
  on property: regulates
  some values from: myeloid cell differentiation
definition: Any process that modulates the frequency, rate or extent of myeloid cell differentiation.
has_obo_namespace: biological_process
id: GO:0045637

Axiom
annotated source: regulation of myeloid cell differentiation
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of myeloid cell differentiation.
database_cross_reference: GOC:go_curators

negative regulation of myeloid cell differentiation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: myeloid cell differentiation
subclass of: negative regulation of cell differentiation
subclass of: regulation of myeloid cell differentiation
subclass of: GO_1903707
subclass of: Restriction
  on property: negatively regulates
  some values from: myeloid cell differentiation
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation.
has_exact_synonym: down regulation of myeloid cell differentiation
has_exact_synonym: down-regulation of myeloid cell differentiation
has_exact_synonym: downregulation of myeloid cell differentiation
has_narrow_synonym: inhibition of myeloid cell differentiation
has_obo_namespace: biological_process
id: GO:0045638

Axiom
annotated source: negative regulation of myeloid cell differentiation
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation.
database_cross_reference: GOC:go_curators

positive regulation of myeloid cell differentiation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: myeloid cell differentiation
subclass of: positive regulation of cell differentiation
subclass of: regulation of myeloid cell differentiation
subclass of: GO_1903708
subclass of: Restriction
  on property: positively regulates
  some values from: myeloid cell differentiation
definition: Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation.
has_exact_synonym: up regulation of myeloid cell differentiation
has_exact_synonym: up-regulation of myeloid cell differentiation
has_exact_synonym: upregulation of myeloid cell differentiation
has_narrow_synonym: activation of myeloid cell differentiation
has_narrow_synonym: stimulation of myeloid cell differentiation
has_obo_namespace: biological_process
id: GO:0045639

Axiom
annotated source: positive regulation of myeloid cell differentiation
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation.
database_cross_reference: GOC:go_curators

regulation of erythrocyte differentiation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: erythrocyte differentiation
subclass of: regulation of myeloid cell differentiation
subclass of: GO_0065008
subclass of: Restriction
  on property: regulates
  some values from: erythrocyte differentiation
definition: Any process that modulates the frequency, rate or extent of erythrocyte differentiation.
has_exact_synonym: regulation of RBC differentiation
has_exact_synonym: regulation of red blood cell differentiation
has_obo_namespace: biological_process
id: GO:0045646

Axiom
annotated source: regulation of erythrocyte differentiation
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of erythrocyte differentiation.
database_cross_reference: GOC:go_curators

Axiom
annotated source: regulation of erythrocyte differentiation
annotated property: has_exact_synonym
annotated target: regulation of RBC differentiation
database_cross_reference: CL:0000232

Axiom
annotated source: regulation of erythrocyte differentiation
annotated property: has_exact_synonym
annotated target: regulation of red blood cell differentiation
database_cross_reference: CL:0000232

negative regulation of erythrocyte differentiation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: erythrocyte differentiation
subclass of: negative regulation of myeloid cell differentiation
subclass of: regulation of erythrocyte differentiation
subclass of: Restriction
  on property: negatively regulates
  some values from: erythrocyte differentiation
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation.
has_exact_synonym: down regulation of erythrocyte differentiation
has_exact_synonym: down-regulation of erythrocyte differentiation
has_exact_synonym: downregulation of erythrocyte differentiation
has_exact_synonym: negative regulation of RBC differentiation
has_exact_synonym: negative regulation of red blood cell differentiation
has_narrow_synonym: inhibition of erythrocyte differentiation
has_obo_namespace: biological_process
id: GO:0045647

Axiom
annotated source: negative regulation of erythrocyte differentiation
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation.
database_cross_reference: GOC:go_curators

Axiom
annotated source: negative regulation of erythrocyte differentiation
annotated property: has_exact_synonym
annotated target: negative regulation of RBC differentiation
database_cross_reference: CL:0000232

Axiom
annotated source: negative regulation of erythrocyte differentiation
annotated property: has_exact_synonym
annotated target: negative regulation of red blood cell differentiation
database_cross_reference: CL:0000232

positive regulation of erythrocyte differentiation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: erythrocyte differentiation
subclass of: positive regulation of myeloid cell differentiation
subclass of: regulation of erythrocyte differentiation
subclass of: Restriction
  on property: positively regulates
  some values from: erythrocyte differentiation
definition: Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.
has_exact_synonym: positive regulation of RBC differentiation
has_exact_synonym: positive regulation of red blood cell differentiation
has_exact_synonym: up regulation of erythrocyte differentiation
has_exact_synonym: up-regulation of erythrocyte differentiation
has_exact_synonym: upregulation of erythrocyte differentiation
has_narrow_synonym: activation of erythrocyte differentiation
has_narrow_synonym: stimulation of erythrocyte differentiation
has_obo_namespace: biological_process
id: GO:0045648

Axiom
annotated source: positive regulation of erythrocyte differentiation
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.
database_cross_reference: GOC:go_curators

Axiom
annotated source: positive regulation of erythrocyte differentiation
annotated property: has_exact_synonym
annotated target: positive regulation of RBC differentiation
database_cross_reference: CL:0000232

Axiom
annotated source: positive regulation of erythrocyte differentiation
annotated property: has_exact_synonym
annotated target: positive regulation of red blood cell differentiation
database_cross_reference: CL:0000232

regulation of neuron differentiation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: neuron differentiation
subclass of: GO_0050767
subclass of: Restriction
  on property: regulates
  some values from: neuron differentiation
definition: Any process that modulates the frequency, rate or extent of neuron differentiation.
has_obo_namespace: biological_process
id: GO:0045664

Axiom
annotated source: regulation of neuron differentiation
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of neuron differentiation.
database_cross_reference: GOC:go_curators

negative regulation of neuron differentiation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: neuron differentiation
subclass of: regulation of neuron differentiation
subclass of: GO_0050768
subclass of: Restriction
  on property: negatively regulates
  some values from: neuron differentiation
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
has_exact_synonym: down regulation of neuron differentiation
has_exact_synonym: down-regulation of neuron differentiation
has_exact_synonym: downregulation of neuron differentiation
has_narrow_synonym: inhibition of neuron differentiation
has_obo_namespace: biological_process
id: GO:0045665

Axiom
annotated source: negative regulation of neuron differentiation
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
database_cross_reference: GOC:go_curators

positive regulation of neuron differentiation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: neuron differentiation
subclass of: regulation of neuron differentiation
subclass of: GO_0050769
subclass of: Restriction
  on property: positively regulates
  some values from: neuron differentiation
definition: Any process that activates or increases the frequency, rate or extent of neuron differentiation.
has_exact_synonym: up regulation of neuron differentiation
has_exact_synonym: up-regulation of neuron differentiation
has_exact_synonym: upregulation of neuron differentiation
has_narrow_synonym: activation of neuron differentiation
has_narrow_synonym: stimulation of neuron differentiation
has_obo_namespace: biological_process
id: GO:0045666

Axiom
annotated source: positive regulation of neuron differentiation
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of neuron differentiation.
database_cross_reference: GOC:go_curators

regulation of spermatid nuclear differentiation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: spermatid nucleus differentiation
subclass of: regulation of multi-organism process
subclass of: GO_0051239
subclass of: GO_0060284
subclass of: GO_1903353
subclass of: GO_2000241
subclass of: Restriction
  on property: regulates
  some values from: spermatid nucleus differentiation
definition: Any process that modulates the frequency, rate or extent of spermatid nuclear differentiation.
has_obo_namespace: biological_process
id: GO:0045700

Axiom
annotated source: regulation of spermatid nuclear differentiation
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of spermatid nuclear differentiation.
database_cross_reference: GOC:go_curators

negative regulation of spermatid nuclear differentiation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: spermatid nucleus differentiation
subclass of: negative regulation of organelle organization
subclass of: negative regulation of cell development
subclass of: negative regulation of multi-organism process
subclass of: regulation of spermatid nuclear differentiation
subclass of: GO_0051241
subclass of: GO_2000242
subclass of: Restriction
  on property: negatively regulates
  some values from: spermatid nucleus differentiation
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of spermatid nuclear differentiation.
has_exact_synonym: down regulation of spermatid nuclear differentiation
has_exact_synonym: down-regulation of spermatid nuclear differentiation
has_exact_synonym: downregulation of spermatid nuclear differentiation
has_narrow_synonym: inhibition of spermatid nuclear differentiation
has_obo_namespace: biological_process
id: GO:0045701

Axiom
annotated source: negative regulation of spermatid nuclear differentiation
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of spermatid nuclear differentiation.
database_cross_reference: GOC:go_curators

positive regulation of spermatid nuclear differentiation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: spermatid nucleus differentiation
subclass of: positive regulation of organelle organization
subclass of: positive regulation of cell development
subclass of: positive regulation of multi-organism process
subclass of: regulation of spermatid nuclear differentiation
subclass of: GO_0051240
subclass of: GO_2000243
subclass of: Restriction
  on property: positively regulates
  some values from: spermatid nucleus differentiation
definition: Any process that activates or increases the frequency, rate or extent of spermatid nuclear differentiation.
has_exact_synonym: up regulation of spermatid nuclear differentiation
has_exact_synonym: up-regulation of spermatid nuclear differentiation
has_exact_synonym: upregulation of spermatid nuclear differentiation
has_narrow_synonym: activation of spermatid nuclear differentiation
has_narrow_synonym: stimulation of spermatid nuclear differentiation
has_obo_namespace: biological_process
id: GO:0045702

Axiom
annotated source: positive regulation of spermatid nuclear differentiation
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of spermatid nuclear differentiation.
database_cross_reference: GOC:go_curators

positive regulation of cilium assembly
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: GO_0060271
subclass of: GO_0120034
subclass of: GO_1902017
subclass of: GO_1902117
subclass of: Restriction
  on property: positively regulates
  some values from: GO_0060271
definition: Any process that activates or increases the frequency, rate or extent of the formation of a cilium.
has_broad_synonym: positive regulation of flagellum assembly
has_exact_synonym: up regulation of cilium assembly
has_exact_synonym: up-regulation of cilium assembly
has_exact_synonym: upregulation of cilium assembly
has_narrow_synonym: activation of cilium assembly
has_narrow_synonym: stimulation of cilium assembly
has_obo_namespace: biological_process
has_related_synonym: positive regulation of flagellum biogenesis
id: GO:0045724

Axiom
annotated source: positive regulation of cilium assembly
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of the formation of a cilium.
database_cross_reference: GOC:cilia
database_cross_reference: GOC:go_curators

Axiom
annotated source: positive regulation of cilium assembly
annotated property: has_related_synonym
annotated target: positive regulation of flagellum biogenesis
database_cross_reference: GOC:mah

negative regulation of G protein-coupled receptor signaling pathway
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: G protein-coupled receptor signaling pathway
subclass of: regulation of G protein-coupled receptor signaling pathway
subclass of: negative regulation of signal transduction
subclass of: Restriction
  on property: negatively regulates
  some values from: G protein-coupled receptor signaling pathway
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway.
has_exact_synonym: down regulation of G-protein coupled receptor protein signaling pathway
has_exact_synonym: down-regulation of G-protein coupled receptor protein signaling pathway
has_exact_synonym: downregulation of G-protein coupled receptor protein signaling pathway
has_exact_synonym: negative regulation of G protein coupled receptor protein signaling pathway
has_exact_synonym: negative regulation of G protein coupled receptor protein signalling pathway
has_exact_synonym: negative regulation of G-protein coupled receptor protein signaling pathway
has_exact_synonym: negative regulation of G-protein coupled receptor protein signalling pathway
has_exact_synonym: negative regulation of G-protein-coupled receptor protein signalling pathway
has_exact_synonym: negative regulation of GPCR protein signaling pathway
has_exact_synonym: negative regulation of GPCR protein signalling pathway
has_narrow_synonym: inhibition of G-protein coupled receptor protein signaling pathway
has_obo_namespace: biological_process
id: GO:0045744

Axiom
annotated source: negative regulation of G protein-coupled receptor signaling pathway
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway.
database_cross_reference: GOC:go_curators

positive regulation of G protein-coupled receptor signaling pathway
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: G protein-coupled receptor signaling pathway
subclass of: regulation of G protein-coupled receptor signaling pathway
subclass of: positive regulation of signal transduction
subclass of: Restriction
  on property: positively regulates
  some values from: G protein-coupled receptor signaling pathway
definition: Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor signaling pathway activity.
has_exact_synonym: positive regulation of G protein coupled receptor protein signaling pathway
has_exact_synonym: positive regulation of G protein coupled receptor protein signalling pathway
has_exact_synonym: positive regulation of G-protein coupled receptor protein signaling pathway
has_exact_synonym: positive regulation of G-protein coupled receptor protein signalling pathway
has_exact_synonym: positive regulation of G-protein-coupled receptor protein signaling pathway
has_exact_synonym: positive regulation of G-protein-coupled receptor protein signalling pathway
has_exact_synonym: positive regulation of GPCR protein signaling pathway
has_exact_synonym: positive regulation of GPCR protein signalling pathway
has_exact_synonym: up regulation of G-protein coupled receptor protein signaling pathway
has_exact_synonym: up-regulation of G-protein coupled receptor protein signaling pathway
has_exact_synonym: upregulation of G-protein coupled receptor protein signaling pathway
has_narrow_synonym: activation of G-protein coupled receptor protein signaling pathway
has_narrow_synonym: stimulation of G-protein coupled receptor protein signaling pathway
has_obo_namespace: biological_process
id: GO:0045745

Axiom
annotated source: positive regulation of G protein-coupled receptor signaling pathway
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor signaling pathway activity.
database_cross_reference: GOC:go_curators

regulation of angiogenesis
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: angiogenesis
subclass of: regulation of anatomical structure morphogenesis
subclass of: GO_1901342
subclass of: Restriction
  on property: regulates
  some values from: angiogenesis
definition: Any process that modulates the frequency, rate or extent of angiogenesis.
has_obo_namespace: biological_process
id: GO:0045765

Axiom
annotated source: regulation of angiogenesis
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of angiogenesis.
database_cross_reference: GOC:go_curators

positive regulation of angiogenesis
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: angiogenesis
subclass of: regulation of angiogenesis
subclass of: GO_1904018
subclass of: Restriction
  on property: positively regulates
  some values from: angiogenesis
definition: Any process that activates or increases angiogenesis.
has_exact_synonym: up regulation of angiogenesis
has_exact_synonym: up-regulation of angiogenesis
has_exact_synonym: upregulation of angiogenesis
has_narrow_synonym: activation of angiogenesis
has_narrow_synonym: stimulation of angiogenesis
has_obo_namespace: biological_process
id: GO:0045766

Axiom
annotated source: positive regulation of angiogenesis
annotated property: definition
annotated target: Any process that activates or increases angiogenesis.
database_cross_reference: GOC:go_curators

negative regulation of asymmetric cell division
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: asymmetric cell division
subclass of: regulation of asymmetric cell division
subclass of: GO_0051782
subclass of: Restriction
  on property: negatively regulates
  some values from: asymmetric cell division
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division.
has_exact_synonym: down regulation of asymmetric cell division
has_exact_synonym: down-regulation of asymmetric cell division
has_exact_synonym: downregulation of asymmetric cell division
has_narrow_synonym: inhibition of asymmetric cell division
has_obo_namespace: biological_process
id: GO:0045769

Axiom
annotated source: negative regulation of asymmetric cell division
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division.
database_cross_reference: GOC:go_curators

positive regulation of asymmetric cell division
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: asymmetric cell division
subclass of: regulation of asymmetric cell division
subclass of: GO_0051781
subclass of: Restriction
  on property: positively regulates
  some values from: asymmetric cell division
definition: Any process that activates or increases the frequency, rate or extent of asymmetric cell division.
has_exact_synonym: up regulation of asymmetric cell division
has_exact_synonym: up-regulation of asymmetric cell division
has_exact_synonym: upregulation of asymmetric cell division
has_narrow_synonym: activation of asymmetric cell division
has_narrow_synonym: stimulation of asymmetric cell division
has_obo_namespace: biological_process
id: GO:0045770

Axiom
annotated source: positive regulation of asymmetric cell division
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of asymmetric cell division.
database_cross_reference: GOC:go_curators

positive regulation of cell adhesion
type: Class
equivalent class: Class
  intersection of: GO_0065007
  intersection of: Restriction
    on property: positively regulates
    some values from: cell adhesion
subclass of: regulation of cell adhesion
subclass of: positive regulation of cellular process
subclass of: Restriction
  on property: positively regulates
  some values from: cell adhesion
definition: Any process that activates or increases the frequency, rate or extent of cell adhesion.
has_exact_synonym: up regulation of cell adhesion
has_exact_synonym: up-regulation of cell adhesion
has_exact_synonym: upregulation of cell adhesion
has_narrow_synonym: activation of cell adhesion
has_narrow_synonym: stimulation of cell adhesion
has_obo_namespace: biological_process
id: GO:0045785

Axiom
annotated source: positive regulation of cell adhesion
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of cell adhesion.
database_cross_reference: GOC:go_curators

negative regulation of cell cycle
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cell cycle
subclass of: negative regulation of cellular process
subclass of: GO_0051726
subclass of: Restriction
  on property: negatively regulates
  some values from: cell cycle
definition: Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
has_exact_synonym: down regulation of progression through cell cycle
has_exact_synonym: down-regulation of progression through cell cycle
has_exact_synonym: downregulation of progression through cell cycle
has_exact_synonym: negative regulation of cell cycle progression
has_exact_synonym: negative regulation of progression through cell cycle
has_narrow_synonym: inhibition of progression through cell cycle
has_obo_namespace: biological_process
id: GO:0045786

Axiom
annotated source: negative regulation of cell cycle
annotated property: definition
annotated target: Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
database_cross_reference: GOC:dph
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:tb

positive regulation of cell cycle
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: cell cycle
subclass of: positive regulation of cellular process
subclass of: GO_0051726
subclass of: Restriction
  on property: positively regulates
  some values from: cell cycle
definition: Any process that activates or increases the rate or extent of progression through the cell cycle.
has_exact_synonym: positive regulation of cell cycle progression
has_exact_synonym: positive regulation of progression through cell cycle
has_exact_synonym: up regulation of progression through cell cycle
has_exact_synonym: up-regulation of progression through cell cycle
has_exact_synonym: upregulation of progression through cell cycle
has_narrow_synonym: activation of progression through cell cycle
has_narrow_synonym: stimulation of progression through cell cycle
has_obo_namespace: biological_process
id: GO:0045787

Axiom
annotated source: positive regulation of cell cycle
annotated property: definition
annotated target: Any process that activates or increases the rate or extent of progression through the cell cycle.
database_cross_reference: GOC:go_curators

Axiom
annotated source: positive regulation of cell cycle
annotated property: has_exact_synonym
annotated target: positive regulation of progression through cell cycle
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

negative regulation of isoprenoid metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: isoprenoid metabolic process
subclass of: regulation of isoprenoid metabolic process
subclass of: negative regulation of cellular metabolic process
subclass of: negative regulation of lipid metabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: isoprenoid metabolic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid.
has_exact_synonym: down regulation of isoprenoid metabolic process
has_exact_synonym: down-regulation of isoprenoid metabolic process
has_exact_synonym: downregulation of isoprenoid metabolic process
has_exact_synonym: negative regulation of isoprenoid metabolism
has_narrow_synonym: inhibition of isoprenoid metabolic process
has_obo_namespace: biological_process
id: GO:0045827

Axiom
annotated source: negative regulation of isoprenoid metabolic process
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid.
database_cross_reference: GOC:go_curators

positive regulation of isoprenoid metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: isoprenoid metabolic process
subclass of: regulation of isoprenoid metabolic process
subclass of: positive regulation of cellular metabolic process
subclass of: positive regulation of lipid metabolic process
subclass of: Restriction
  on property: positively regulates
  some values from: isoprenoid metabolic process
definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid.
has_exact_synonym: positive regulation of isoprenoid metabolism
has_exact_synonym: up regulation of isoprenoid metabolic process
has_exact_synonym: up-regulation of isoprenoid metabolic process
has_exact_synonym: upregulation of isoprenoid metabolic process
has_narrow_synonym: activation of isoprenoid metabolic process
has_narrow_synonym: stimulation of isoprenoid metabolic process
has_obo_namespace: biological_process
id: GO:0045828

Axiom
annotated source: positive regulation of isoprenoid metabolic process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid.
database_cross_reference: GOC:go_curators

negative regulation of lipid metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: lipid metabolic process
subclass of: negative regulation of metabolic process
subclass of: regulation of lipid metabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: lipid metabolic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids.
has_exact_synonym: down regulation of lipid metabolic process
has_exact_synonym: down-regulation of lipid metabolic process
has_exact_synonym: downregulation of lipid metabolic process
has_exact_synonym: negative regulation of lipid metabolism
has_narrow_synonym: inhibition of lipid metabolic process
has_obo_namespace: biological_process
id: GO:0045833

Axiom
annotated source: negative regulation of lipid metabolic process
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids.
database_cross_reference: GOC:go_curators

positive regulation of lipid metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: lipid metabolic process
subclass of: positive regulation of metabolic process
subclass of: regulation of lipid metabolic process
subclass of: Restriction
  on property: positively regulates
  some values from: lipid metabolic process
definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids.
has_exact_synonym: positive regulation of lipid metabolism
has_exact_synonym: up regulation of lipid metabolic process
has_exact_synonym: up-regulation of lipid metabolic process
has_exact_synonym: upregulation of lipid metabolic process
has_narrow_synonym: activation of lipid metabolic process
has_narrow_synonym: stimulation of lipid metabolic process
has_obo_namespace: biological_process
id: GO:0045834

Axiom
annotated source: positive regulation of lipid metabolic process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids.
database_cross_reference: GOC:go_curators

negative regulation of meiotic nuclear division
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: GO_0140013
subclass of: negative regulation of cell cycle process
subclass of: regulation of meiotic nuclear division
subclass of: GO_0051447
subclass of: GO_0051784
subclass of: Restriction
  on property: negatively regulates
  some values from: GO_0140013
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis.
has_exact_synonym: down regulation of meiosis
has_exact_synonym: down-regulation of meiosis
has_exact_synonym: downregulation of meiosis
has_exact_synonym: negative regulation of meiosis
has_narrow_synonym: inhibition of meiosis
has_obo_namespace: biological_process
id: GO:0045835

Axiom
annotated source: negative regulation of meiotic nuclear division
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis.
database_cross_reference: GOC:go_curators

positive regulation of meiotic nuclear division
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: GO_0140013
subclass of: regulation of meiotic nuclear division
subclass of: GO_0051446
subclass of: GO_0051785
subclass of: GO_0090068
subclass of: Restriction
  on property: positively regulates
  some values from: GO_0140013
definition: Any process that activates or increases the frequency, rate or extent of meiosis.
has_exact_synonym: positive regulation of meiosis
has_exact_synonym: up regulation of meiosis
has_exact_synonym: up-regulation of meiosis
has_exact_synonym: upregulation of meiosis
has_narrow_synonym: activation of meiosis
has_narrow_synonym: stimulation of meiosis
has_obo_namespace: biological_process
id: GO:0045836

Axiom
annotated source: positive regulation of meiotic nuclear division
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of meiosis.
database_cross_reference: GOC:go_curators

negative regulation of mitotic nuclear division
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: GO_0140014
subclass of: regulation of mitotic nuclear division
subclass of: negative regulation of cell cycle process
subclass of: negative regulation of mitotic cell cycle
subclass of: GO_0051784
subclass of: Restriction
  on property: negatively regulates
  some values from: GO_0140014
definition: Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother.
has_exact_synonym: down regulation of mitosis
has_exact_synonym: down-regulation of mitosis
has_exact_synonym: downregulation of mitosis
has_exact_synonym: negative regulation of mitosis
has_narrow_synonym: inhibition of mitosis
has_obo_namespace: biological_process
id: GO:0045839

Axiom
annotated source: negative regulation of mitotic nuclear division
annotated property: definition
annotated target: Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother.
database_cross_reference: GOC:dph
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:tb

positive regulation of mitotic nuclear division
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: GO_0140014
subclass of: regulation of mitotic nuclear division
subclass of: positive regulation of mitotic cell cycle
subclass of: GO_0051785
subclass of: GO_0090068
subclass of: Restriction
  on property: positively regulates
  some values from: GO_0140014
definition: Any process that activates or increases the frequency, rate or extent of mitosis.
has_exact_synonym: positive regulation of mitosis
has_exact_synonym: up regulation of mitosis
has_exact_synonym: up-regulation of mitosis
has_exact_synonym: upregulation of mitosis
has_narrow_synonym: activation of mitosis
has_narrow_synonym: mitogenic activity
has_narrow_synonym: stimulation of mitosis
has_obo_namespace: biological_process
id: GO:0045840

Axiom
annotated source: positive regulation of mitotic nuclear division
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of mitosis.
database_cross_reference: GOC:go_curators

negative regulation of proteolysis
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: proteolysis
subclass of: regulation of proteolysis
subclass of: negative regulation of cellular protein metabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: proteolysis
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
has_exact_synonym: down regulation of proteolysis
has_exact_synonym: down-regulation of proteolysis
has_exact_synonym: downregulation of proteolysis
has_exact_synonym: negative regulation of peptidolysis
has_narrow_synonym: inhibition of proteolysis
has_obo_namespace: biological_process
id: GO:0045861

Axiom
annotated source: negative regulation of proteolysis
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
database_cross_reference: GOC:go_curators

positive regulation of proteolysis
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: proteolysis
subclass of: regulation of proteolysis
subclass of: positive regulation of cellular protein metabolic process
subclass of: Restriction
  on property: positively regulates
  some values from: proteolysis
definition: Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
has_exact_synonym: positive regulation of peptidolysis
has_exact_synonym: up regulation of proteolysis
has_exact_synonym: up-regulation of proteolysis
has_exact_synonym: upregulation of proteolysis
has_narrow_synonym: activation of proteolysis
has_narrow_synonym: stimulation of proteolysis
has_obo_namespace: biological_process
id: GO:0045862

Axiom
annotated source: positive regulation of proteolysis
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
database_cross_reference: GOC:go_curators

negative regulation of transcription, DNA-templated
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: transcription, DNA-templated
subclass of: regulation of transcription, DNA-templated
subclass of: negative regulation of gene expression
subclass of: GO_1903507
subclass of: GO_2000113
subclass of: Restriction
  on property: negatively regulates
  some values from: transcription, DNA-templated
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
has_alternative_id: GO:0016481
has_alternative_id: GO:0032582
has_alternative_id: GO:0061021
has_exact_synonym: down regulation of transcription, DNA-dependent
has_exact_synonym: down-regulation of transcription, DNA-dependent
has_exact_synonym: downregulation of transcription, DNA-dependent
has_exact_synonym: negative regulation of cellular transcription, DNA-dependent
has_exact_synonym: negative regulation of transcription, DNA-dependent
has_narrow_synonym: inhibition of transcription, DNA-dependent
has_obo_namespace: biological_process
has_related_synonym: down regulation of gene-specific transcription
has_related_synonym: down-regulation of gene-specific transcription
has_related_synonym: downregulation of gene-specific transcription
has_related_synonym: inhibition of gene-specific transcription
has_related_synonym: negative regulation of gene-specific transcription
has_related_synonym: transcription repressor activity
id: GO:0045892

Axiom
annotated source: negative regulation of transcription, DNA-templated
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:txnOH

Axiom
annotated source: negative regulation of transcription, DNA-templated
annotated property: has_exact_synonym
annotated target: negative regulation of transcription, DNA-dependent
database_cross_reference: GOC:txnOH

positive regulation of transcription, DNA-templated
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: transcription, DNA-templated
subclass of: regulation of transcription, DNA-templated
subclass of: positive regulation of gene expression
subclass of: GO_1903508
subclass of: Restriction
  on property: positively regulates
  some values from: transcription, DNA-templated
definition: Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
has_alternative_id: GO:0043193
has_alternative_id: GO:0045941
has_alternative_id: GO:0061020
has_exact_synonym: positive regulation of cellular transcription, DNA-dependent
has_exact_synonym: positive regulation of transcription, DNA-dependent
has_exact_synonym: up regulation of transcription, DNA-dependent
has_exact_synonym: up-regulation of transcription, DNA-dependent
has_exact_synonym: upregulation of transcription, DNA-dependent
has_narrow_synonym: activation of transcription, DNA-dependent
has_narrow_synonym: stimulation of gene-specific transcription
has_narrow_synonym: stimulation of transcription, DNA-dependent
has_obo_namespace: biological_process
has_related_synonym: activation of gene-specific transcription
has_related_synonym: positive regulation of gene-specific transcription
has_related_synonym: transcription activator activity
has_related_synonym: up regulation of gene-specific transcription
has_related_synonym: up-regulation of gene-specific transcription
has_related_synonym: upregulation of gene-specific transcription
id: GO:0045893

Axiom
annotated source: positive regulation of transcription, DNA-templated
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:txnOH

Axiom
annotated source: positive regulation of transcription, DNA-templated
annotated property: has_exact_synonym
annotated target: positive regulation of transcription, DNA-dependent
database_cross_reference: GOC:txnOH

negative regulation of carbohydrate metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: carbohydrate metabolic process
subclass of: regulation of carbohydrate metabolic process
subclass of: negative regulation of metabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: carbohydrate metabolic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate.
has_exact_synonym: down regulation of carbohydrate metabolic process
has_exact_synonym: down-regulation of carbohydrate metabolic process
has_exact_synonym: downregulation of carbohydrate metabolic process
has_exact_synonym: negative regulation of carbohydrate metabolism
has_narrow_synonym: inhibition of carbohydrate metabolic process
has_obo_namespace: biological_process
id: GO:0045912

Axiom
annotated source: negative regulation of carbohydrate metabolic process
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate.
database_cross_reference: GOC:go_curators

positive regulation of carbohydrate metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: carbohydrate metabolic process
subclass of: regulation of carbohydrate metabolic process
subclass of: positive regulation of metabolic process
subclass of: Restriction
  on property: positively regulates
  some values from: carbohydrate metabolic process
definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate.
has_exact_synonym: positive regulation of carbohydrate metabolism
has_exact_synonym: up regulation of carbohydrate metabolic process
has_exact_synonym: up-regulation of carbohydrate metabolic process
has_exact_synonym: upregulation of carbohydrate metabolic process
has_narrow_synonym: activation of carbohydrate metabolic process
has_narrow_synonym: stimulation of carbohydrate metabolic process
has_obo_namespace: biological_process
id: GO:0045913

Axiom
annotated source: positive regulation of carbohydrate metabolic process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate.
database_cross_reference: GOC:go_curators

negative regulation of growth
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: growth
subclass of: regulation of growth
subclass of: negative regulation of biological process
subclass of: Restriction
  on property: negatively regulates
  some values from: growth
definition: Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism.
has_exact_synonym: down regulation of growth
has_exact_synonym: down-regulation of growth
has_exact_synonym: downregulation of growth
has_narrow_synonym: inhibition of growth
has_obo_namespace: biological_process
id: GO:0045926

Axiom
annotated source: negative regulation of growth
annotated property: definition
annotated target: Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism.
database_cross_reference: GOC:go_curators

positive regulation of growth
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: growth
subclass of: regulation of growth
subclass of: positive regulation of biological process
subclass of: Restriction
  on property: positively regulates
  some values from: growth
definition: Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism.
has_exact_synonym: up regulation of growth
has_exact_synonym: up-regulation of growth
has_exact_synonym: upregulation of growth
has_narrow_synonym: activation of growth
has_narrow_synonym: stimulation of growth
has_obo_namespace: biological_process
id: GO:0045927

Axiom
annotated source: positive regulation of growth
annotated property: definition
annotated target: Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism.
database_cross_reference: GOC:go_curators

negative regulation of mitotic cell cycle
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: mitotic cell cycle
subclass of: regulation of mitotic cell cycle
subclass of: negative regulation of cell cycle
subclass of: Restriction
  on property: negatively regulates
  some values from: mitotic cell cycle
definition: Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.
has_exact_synonym: down regulation of progression through mitotic cell cycle
has_exact_synonym: down-regulation of progression through mitotic cell cycle
has_exact_synonym: downregulation of progression through mitotic cell cycle
has_exact_synonym: negative regulation of mitotic cell cycle progression
has_exact_synonym: negative regulation of progression through mitotic cell cycle
has_narrow_synonym: inhibition of progression through mitotic cell cycle
has_obo_namespace: biological_process
id: GO:0045930

Axiom
annotated source: negative regulation of mitotic cell cycle
annotated property: definition
annotated target: Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.
database_cross_reference: GOC:dph
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:tb

Axiom
annotated source: negative regulation of mitotic cell cycle
annotated property: has_exact_synonym
annotated target: negative regulation of progression through mitotic cell cycle
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

positive regulation of mitotic cell cycle
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: mitotic cell cycle
subclass of: regulation of mitotic cell cycle
subclass of: positive regulation of cell cycle
subclass of: Restriction
  on property: positively regulates
  some values from: mitotic cell cycle
definition: Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.
has_exact_synonym: positive regulation of mitotic cell cycle progression
has_exact_synonym: positive regulation of progression through mitotic cell cycle
has_exact_synonym: up regulation of progression through mitotic cell cycle
has_exact_synonym: up-regulation of progression through mitotic cell cycle
has_exact_synonym: upregulation of progression through mitotic cell cycle
has_narrow_synonym: activation of progression through mitotic cell cycle
has_narrow_synonym: stimulation of progression through mitotic cell cycle
has_obo_namespace: biological_process
id: GO:0045931

Axiom
annotated source: positive regulation of mitotic cell cycle
annotated property: definition
annotated target: Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.
database_cross_reference: GOC:dph
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:tb

Axiom
annotated source: positive regulation of mitotic cell cycle
annotated property: has_exact_synonym
annotated target: positive regulation of progression through mitotic cell cycle
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

negative regulation of nucleobase-containing compound metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: nucleobase-containing compound metabolic process
subclass of: regulation of nucleobase-containing compound metabolic process
subclass of: negative regulation of cellular metabolic process
subclass of: GO_0051172
subclass of: Restriction
  on property: negatively regulates
  some values from: nucleobase-containing compound metabolic process
definition: Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
has_exact_synonym: down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
has_exact_synonym: down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
has_exact_synonym: downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
has_exact_synonym: negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
has_narrow_synonym: inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
has_obo_namespace: biological_process
has_related_synonym: negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
id: GO:0045934

Axiom
annotated source: negative regulation of nucleobase-containing compound metabolic process
annotated property: definition
annotated target: Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
database_cross_reference: GOC:go_curators

Axiom
annotated source: negative regulation of nucleobase-containing compound metabolic process
annotated property: has_related_synonym
annotated target: negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

positive regulation of nucleobase-containing compound metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: nucleobase-containing compound metabolic process
subclass of: regulation of nucleobase-containing compound metabolic process
subclass of: positive regulation of cellular metabolic process
subclass of: GO_0051173
subclass of: Restriction
  on property: positively regulates
  some values from: nucleobase-containing compound metabolic process
definition: Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
has_exact_synonym: positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
has_exact_synonym: up regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
has_exact_synonym: up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
has_exact_synonym: upregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
has_narrow_synonym: activation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
has_narrow_synonym: stimulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
has_obo_namespace: biological_process
has_related_synonym: positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
id: GO:0045935

Axiom
annotated source: positive regulation of nucleobase-containing compound metabolic process
annotated property: definition
annotated target: Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
database_cross_reference: GOC:go_curators

Axiom
annotated source: positive regulation of nucleobase-containing compound metabolic process
annotated property: has_related_synonym
annotated target: positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

negative regulation of phosphate metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: phosphate-containing compound metabolic process
subclass of: negative regulation of phosphorus metabolic process
subclass of: regulation of phosphate metabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: phosphate-containing compound metabolic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates.
has_exact_synonym: down regulation of phosphate metabolic process
has_exact_synonym: down-regulation of phosphate metabolic process
has_exact_synonym: downregulation of phosphate metabolic process
has_exact_synonym: negative regulation of phosphate metabolism
has_narrow_synonym: inhibition of phosphate metabolic process
has_obo_namespace: biological_process
id: GO:0045936

Axiom
annotated source: negative regulation of phosphate metabolic process
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates.
database_cross_reference: GOC:go_curators

positive regulation of phosphate metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: phosphate-containing compound metabolic process
subclass of: positive regulation of phosphorus metabolic process
subclass of: regulation of phosphate metabolic process
subclass of: Restriction
  on property: positively regulates
  some values from: phosphate-containing compound metabolic process
definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates.
has_exact_synonym: positive regulation of phosphate metabolism
has_exact_synonym: up regulation of phosphate metabolic process
has_exact_synonym: up-regulation of phosphate metabolic process
has_exact_synonym: upregulation of phosphate metabolic process
has_narrow_synonym: activation of phosphate metabolic process
has_narrow_synonym: stimulation of phosphate metabolic process
has_obo_namespace: biological_process
id: GO:0045937

Axiom
annotated source: positive regulation of phosphate metabolic process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates.
database_cross_reference: GOC:go_curators

positive regulation of circadian sleep/wake cycle, sleep
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: GO_0050802
subclass of: positive regulation of circadian rhythm
subclass of: regulation of circadian sleep/wake cycle, sleep
subclass of: positive regulation of behavior
subclass of: GO_0051240
subclass of: Restriction
  on property: positively regulates
  some values from: GO_0050802
definition: Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.
has_exact_synonym: positive regulation of sleep
has_exact_synonym: up regulation of circadian sleep/wake cycle, sleep
has_exact_synonym: up-regulation of circadian sleep/wake cycle, sleep
has_exact_synonym: upregulation of circadian sleep/wake cycle, sleep
has_narrow_synonym: activation of circadian sleep/wake cycle, sleep
has_narrow_synonym: stimulation of circadian sleep/wake cycle, sleep
has_obo_namespace: biological_process
id: GO:0045938

Axiom
annotated source: positive regulation of circadian sleep/wake cycle, sleep
annotated property: definition
annotated target: Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.
database_cross_reference: GOC:go_curators

positive regulation of transcription by RNA polymerase II
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: transcription by RNA polymerase II
subclass of: regulation of transcription by RNA polymerase II
subclass of: positive regulation of transcription, DNA-templated
subclass of: Restriction
  on property: positively regulates
  some values from: transcription by RNA polymerase II
definition: Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
has_alternative_id: GO:0010552
has_alternative_id: GO:0045817
has_exact_synonym: activation of transcription from RNA polymerase II promoter
has_exact_synonym: positive regulation of transcription from Pol II promoter
has_exact_synonym: positive regulation of transcription from RNA polymerase II promoter
has_exact_synonym: stimulation of transcription from RNA polymerase II promoter
has_exact_synonym: up regulation of transcription from RNA polymerase II promoter
has_exact_synonym: up-regulation of transcription from RNA polymerase II promoter
has_exact_synonym: upregulation of transcription from RNA polymerase II promoter
has_narrow_synonym: stimulation of global transcription from RNA polymerase II promoter
has_obo_namespace: biological_process
has_related_synonym: activation of global transcription from RNA polymerase II promoter
has_related_synonym: positive regulation of gene-specific transcription from RNA polymerase II promoter
has_related_synonym: positive regulation of global transcription from Pol II promoter
has_related_synonym: positive regulation of transcription from RNA polymerase II promoter, global
has_related_synonym: up regulation of global transcription from RNA polymerase II promoter
has_related_synonym: up-regulation of global transcription from RNA polymerase II promoter
has_related_synonym: upregulation of global transcription from RNA polymerase II promoter
id: GO:0045944

Axiom
annotated source: positive regulation of transcription by RNA polymerase II
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:txnOH

negative regulation of nucleoside metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: nucleoside metabolic process
subclass of: regulation of nucleoside metabolic process
subclass of: negative regulation of nucleobase-containing compound metabolic process
subclass of: GO_0062014
subclass of: Restriction
  on property: negatively regulates
  some values from: nucleoside metabolic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleosides.
has_exact_synonym: down regulation of nucleoside metabolic process
has_exact_synonym: down-regulation of nucleoside metabolic process
has_exact_synonym: downregulation of nucleoside metabolic process
has_exact_synonym: negative regulation of nucleoside metabolism
has_narrow_synonym: inhibition of nucleoside metabolic process
has_obo_namespace: biological_process
id: GO:0045978

Axiom
annotated source: negative regulation of nucleoside metabolic process
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleosides.
database_cross_reference: GOC:go_curators

positive regulation of nucleoside metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: nucleoside metabolic process
subclass of: regulation of nucleoside metabolic process
subclass of: positive regulation of nucleobase-containing compound metabolic process
subclass of: GO_0062013
subclass of: Restriction
  on property: positively regulates
  some values from: nucleoside metabolic process
definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleosides.
has_exact_synonym: positive regulation of nucleoside metabolism
has_exact_synonym: up regulation of nucleoside metabolic process
has_exact_synonym: up-regulation of nucleoside metabolic process
has_exact_synonym: upregulation of nucleoside metabolic process
has_narrow_synonym: activation of nucleoside metabolic process
has_narrow_synonym: stimulation of nucleoside metabolic process
has_obo_namespace: biological_process
id: GO:0045979

Axiom
annotated source: positive regulation of nucleoside metabolic process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleosides.
database_cross_reference: GOC:go_curators

negative regulation of nucleotide metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: nucleotide metabolic process
subclass of: regulation of nucleotide metabolic process
subclass of: negative regulation of nucleobase-containing compound metabolic process
subclass of: negative regulation of phosphate metabolic process
subclass of: GO_0062014
subclass of: Restriction
  on property: negatively regulates
  some values from: nucleotide metabolic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides.
has_exact_synonym: down regulation of nucleotide metabolic process
has_exact_synonym: down-regulation of nucleotide metabolic process
has_exact_synonym: downregulation of nucleotide metabolic process
has_exact_synonym: negative regulation of nucleotide metabolism
has_narrow_synonym: inhibition of nucleotide metabolic process
has_obo_namespace: biological_process
id: GO:0045980

Axiom
annotated source: negative regulation of nucleotide metabolic process
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides.
database_cross_reference: GOC:go_curators

positive regulation of nucleotide metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: nucleotide metabolic process
subclass of: regulation of nucleotide metabolic process
subclass of: positive regulation of nucleobase-containing compound metabolic process
subclass of: positive regulation of phosphate metabolic process
subclass of: GO_0062013
subclass of: Restriction
  on property: positively regulates
  some values from: nucleotide metabolic process
definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleotides.
has_exact_synonym: positive regulation of nucleotide metabolism
has_exact_synonym: up regulation of nucleotide metabolic process
has_exact_synonym: up-regulation of nucleotide metabolic process
has_exact_synonym: upregulation of nucleotide metabolic process
has_narrow_synonym: activation of nucleotide metabolic process
has_narrow_synonym: stimulation of nucleotide metabolic process
has_obo_namespace: biological_process
id: GO:0045981

Axiom
annotated source: positive regulation of nucleotide metabolic process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleotides.
database_cross_reference: GOC:go_curators

negative regulation of embryonic development
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: embryo development
subclass of: regulation of embryonic development
subclass of: GO_0051093
subclass of: GO_0051241
subclass of: Restriction
  on property: negatively regulates
  some values from: embryo development
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development.
has_exact_synonym: down regulation of embryonic development
has_exact_synonym: down-regulation of embryonic development
has_exact_synonym: downregulation of embryonic development
has_narrow_synonym: inhibition of embryonic development
has_obo_namespace: biological_process
id: GO:0045992

Axiom
annotated source: negative regulation of embryonic development
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development.
database_cross_reference: GOC:go_curators

regulation of embryonic development
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: embryo development
subclass of: GO_2000026
subclass of: Restriction
  on property: regulates
  some values from: embryo development
definition: Any process that modulates the frequency, rate or extent of embryonic development.
has_obo_namespace: biological_process
id: GO:0045995

Axiom
annotated source: regulation of embryonic development
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of embryonic development.
database_cross_reference: GOC:go_curators

positive regulation of circadian sleep/wake cycle, REM sleep
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: circadian sleep/wake cycle, REM sleep
subclass of: regulation of circadian sleep/wake cycle, REM sleep
subclass of: positive regulation of circadian sleep/wake cycle, sleep
subclass of: Restriction
  on property: positively regulates
  some values from: circadian sleep/wake cycle, REM sleep
definition: Any process that activates or increases the duration or quality of rapid eye movement (REM) sleep.
has_exact_synonym: positive regulation of REM sleep
has_exact_synonym: up regulation of circadian sleep/wake cycle, REM sleep
has_exact_synonym: up-regulation of circadian sleep/wake cycle, REM sleep
has_exact_synonym: upregulation of circadian sleep/wake cycle, REM sleep
has_narrow_synonym: activation of circadian sleep/wake cycle, REM sleep
has_narrow_synonym: stimulation of circadian sleep/wake cycle, REM sleep
has_obo_namespace: biological_process
id: GO:0046005

Axiom
annotated source: positive regulation of circadian sleep/wake cycle, REM sleep
annotated property: definition
annotated target: Any process that activates or increases the duration or quality of rapid eye movement (REM) sleep.
database_cross_reference: GOC:go_curators

positive regulation of circadian sleep/wake cycle, non-REM sleep
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: circadian sleep/wake cycle, non-REM sleep
subclass of: regulation of circadian sleep/wake cycle, non-REM sleep
subclass of: positive regulation of circadian sleep/wake cycle, sleep
subclass of: Restriction
  on property: positively regulates
  some values from: circadian sleep/wake cycle, non-REM sleep
definition: Any process that activates or increases the duration or quality of non-rapid eye movement (NREM) sleep.
has_exact_synonym: positive regulation of non-REM sleep
has_exact_synonym: up regulation of circadian sleep/wake cycle, non-REM sleep
has_exact_synonym: up-regulation of circadian sleep/wake cycle, non-REM sleep
has_exact_synonym: upregulation of circadian sleep/wake cycle, non-REM sleep
has_narrow_synonym: activation of circadian sleep/wake cycle, non-REM sleep
has_narrow_synonym: stimulation of circadian sleep/wake cycle, non-REM sleep
has_obo_namespace: biological_process
id: GO:0046010

Axiom
annotated source: positive regulation of circadian sleep/wake cycle, non-REM sleep
annotated property: definition
annotated target: Any process that activates or increases the duration or quality of non-rapid eye movement (NREM) sleep.
database_cross_reference: GOC:go_curators

ATP metabolic process
type: Class
subclass of: metabolic process
definition: The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator.
has_exact_synonym: ATP metabolism
has_obo_namespace: biological_process
id: GO:0046034

Axiom
annotated source: ATP metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator.
database_cross_reference: GOC:go_curators

purine ribonucleoside metabolic process
type: Class
subclass of: ribonucleoside metabolic process
subclass of: purine nucleoside metabolic process
definition: The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule.
has_exact_synonym: purine ribonucleoside metabolism
has_obo_namespace: biological_process
id: GO:0046128

Axiom
annotated source: purine ribonucleoside metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule.
database_cross_reference: GOC:ai

purine ribonucleoside biosynthetic process
type: Class
subclass of: purine nucleoside biosynthetic process
subclass of: ribonucleoside biosynthetic process
subclass of: purine ribonucleoside metabolic process
definition: The chemical reactions and pathways resulting in the formation of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule.
has_exact_synonym: purine ribonucleoside anabolism
has_exact_synonym: purine ribonucleoside biosynthesis
has_exact_synonym: purine ribonucleoside formation
has_exact_synonym: purine ribonucleoside synthesis
has_obo_namespace: biological_process
id: GO:0046129

Axiom
annotated source: purine ribonucleoside biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule.
database_cross_reference: GOC:ai

positive regulation of vitamin metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: vitamin metabolic process
subclass of: regulation of vitamin metabolic process
subclass of: GO_0062013
subclass of: Restriction
  on property: positively regulates
  some values from: vitamin metabolic process
definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.
has_exact_synonym: positive regulation of vitamin metabolism
has_exact_synonym: up regulation of vitamin metabolic process
has_exact_synonym: up-regulation of vitamin metabolic process
has_exact_synonym: upregulation of vitamin metabolic process
has_narrow_synonym: activation of vitamin metabolic process
has_narrow_synonym: stimulation of vitamin metabolic process
has_obo_namespace: biological_process
id: GO:0046136

Axiom
annotated source: positive regulation of vitamin metabolic process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.
database_cross_reference: GOC:ai

negative regulation of vitamin metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: vitamin metabolic process
subclass of: regulation of vitamin metabolic process
subclass of: GO_0062014
subclass of: Restriction
  on property: negatively regulates
  some values from: vitamin metabolic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.
has_exact_synonym: down regulation of vitamin metabolic process
has_exact_synonym: down-regulation of vitamin metabolic process
has_exact_synonym: downregulation of vitamin metabolic process
has_exact_synonym: negative regulation of vitamin metabolism
has_narrow_synonym: inhibition of vitamin metabolic process
has_obo_namespace: biological_process
id: GO:0046137

Axiom
annotated source: negative regulation of vitamin metabolic process
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.
database_cross_reference: GOC:ai

ribose phosphate biosynthetic process
type: Class
subclass of: ribose phosphate metabolic process
subclass of: GO_0090407
subclass of: GO_1901137
definition: The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar.
has_exact_synonym: ribose phosphate anabolism
has_exact_synonym: ribose phosphate biosynthesis
has_exact_synonym: ribose phosphate formation
has_exact_synonym: ribose phosphate synthesis
has_obo_namespace: biological_process
id: GO:0046390

Axiom
annotated source: ribose phosphate biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar.
database_cross_reference: GOC:ai

heterocycle metabolic process
type: Class
subclass of: cellular metabolic process
definition: The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
has_exact_synonym: heterocycle metabolism
has_obo_namespace: biological_process
id: GO:0046483
in_subset: goslim pir

Axiom
annotated source: heterocycle metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
database_cross_reference: ISBN:0198506732

lymphocyte activation
type: Class
subclass of: leukocyte activation
definition: A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor.
has_obo_namespace: biological_process
id: GO:0046649

Axiom
annotated source: lymphocyte activation
annotated property: definition
annotated target: A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor.
database_cross_reference: GOC:mgi_curators
database_cross_reference: ISBN:0781735149

folic acid metabolic process
type: Class
subclass of: folic acid-containing compound metabolic process
subclass of: water-soluble vitamin metabolic process
subclass of: drug metabolic process
subclass of: dicarboxylic acid metabolic process
definition: The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
has_exact_synonym: folate metabolic process
has_exact_synonym: folate metabolism
has_exact_synonym: folic acid metabolism
has_exact_synonym: vitamin B9 metabolic process
has_exact_synonym: vitamin B9 metabolism
has_exact_synonym: vitamin M metabolic process
has_exact_synonym: vitamin M metabolism
has_obo_namespace: biological_process
id: GO:0046655

Axiom
annotated source: folic acid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
database_cross_reference: ISBN:0198506732

response to antibiotic
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
has_obo_namespace: biological_process
has_related_synonym: antibiotic susceptibility/resistance
id: GO:0046677
in_subset: goslim chembl

Axiom
annotated source: response to antibiotic
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
database_cross_reference: GOC:ai
database_cross_reference: GOC:ef

chlorosome
type: Class
subclass of: intracellular non-membrane-bounded organelle
definition: A large enclosure of aggregated pigment, typically bacteriochlorophyll c (BChl c), that acts as a light-harvesting antenna structure and is characteristic of green photosynthetic bacteria (e.g. Chlorobiaceae). The BChl aggregates are organized into lamellar elements by pigment-pigment rather than pigment-protein interactions. Chlorosomes also contain BChl a, carotenoids, quinones, lipids, and proteins, and are attached to the cytoplasmic membrane via a BChl a-containing protein baseplate.
database_cross_reference: Wikipedia:Chlorosome
has_obo_namespace: cellular_component
id: GO:0046858

Axiom
annotated source: chlorosome
annotated property: definition
annotated target: A large enclosure of aggregated pigment, typically bacteriochlorophyll c (BChl c), that acts as a light-harvesting antenna structure and is characteristic of green photosynthetic bacteria (e.g. Chlorobiaceae). The BChl aggregates are organized into lamellar elements by pigment-pigment rather than pigment-protein interactions. Chlorosomes also contain BChl a, carotenoids, quinones, lipids, and proteins, and are attached to the cytoplasmic membrane via a BChl a-containing protein baseplate.
database_cross_reference: ISBN:0198506732
database_cross_reference: PMID:14729689
database_cross_reference: PMID:15298919

secretion
type: Class
subclass of: transport
definition: The controlled release of a substance by a cell or a tissue.
has_obo_namespace: biological_process
id: GO:0046903
in_subset: goslim pir

Axiom
annotated source: secretion
annotated property: definition
annotated target: The controlled release of a substance by a cell or a tissue.
database_cross_reference: GOC:ai

intracellular transport
type: Class
equivalent class: Class
  intersection of: transport
  intersection of: Restriction
    on property: occurs in
    some values from: intracellular
subclass of: transport
subclass of: GO_0051641
subclass of: GO_0051649
subclass of: Restriction
  on property: occurs in
  some values from: intracellular
definition: The directed movement of substances within a cell.
created by: jl
creation date: 2013-12-18T14:04:50Z
has_alternative_id: GO:1902582
has_obo_namespace: biological_process
has_related_synonym: single organism intracellular transport
has_related_synonym: single-organism intracellular transport
id: GO:0046907

Axiom
annotated source: intracellular transport
annotated property: definition
annotated target: The directed movement of substances within a cell.
database_cross_reference: GOC:ai

Axiom
annotated source: intracellular transport
annotated property: has_related_synonym
annotated target: single organism intracellular transport
database_cross_reference: GOC:TermGenie

carboxylic acid transport
type: Class
subclass of: organic anion transport
subclass of: organic acid transport
definition: The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).
has_obo_namespace: biological_process
id: GO:0046942

Axiom
annotated source: carboxylic acid transport
annotated property: definition
annotated target: The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).
database_cross_reference: GOC:ai

carboxylic acid transmembrane transporter activity
type: Class
subclass of: organic acid transmembrane transporter activity
subclass of: organic anion transmembrane transporter activity
subclass of: inorganic molecular entity transmembrane transporter activity
subclass of: Restriction
  on property: part of
  some values from: GO_1905039
definition: Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).
database_cross_reference: Reactome:R-HSA-390347
has_obo_namespace: molecular_function
id: GO:0046943

Axiom
annotated source: carboxylic acid transmembrane transporter activity
annotated property: definition
annotated target: Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).
database_cross_reference: GOC:ai

Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane
type: Axiom
annotated source: carboxylic acid transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-390347

positive phototaxis
type: Class
subclass of: phototaxis
subclass of: GO_0052128
definition: The directed movement of a cell or organism towards a source of light.
has_alternative_id: GO:0046954
has_exact_synonym: positive phototactic behavior
has_exact_synonym: positive phototactic behaviour
has_exact_synonym: positive taxis in response to light
has_obo_namespace: biological_process
id: GO:0046956

Axiom
annotated source: positive phototaxis
annotated property: definition
annotated target: The directed movement of a cell or organism towards a source of light.
database_cross_reference: GOC:ai

negative phototaxis
type: Class
subclass of: phototaxis
subclass of: GO_0052129
definition: The directed movement of a cell or organism away from a source of light.
has_alternative_id: GO:0046955
has_exact_synonym: negative phototactic behavior
has_exact_synonym: negative phototactic behaviour
has_exact_synonym: negative taxis in response to light
has_obo_namespace: biological_process
id: GO:0046957

Axiom
annotated source: negative phototaxis
annotated property: definition
annotated target: The directed movement of a cell or organism away from a source of light.
database_cross_reference: GOC:ai

nonassociative learning
type: Class
subclass of: learning
definition: A simple form of learning whereby the repeated presence of a stimulus leads to a change in the probability or strength of the response to that stimulus. There is no association of one type of stimulus with another, rather it is a generalized response to the environment.
has_exact_synonym: unconditional response
has_obo_namespace: biological_process
id: GO:0046958

Axiom
annotated source: nonassociative learning
annotated property: definition
annotated target: A simple form of learning whereby the repeated presence of a stimulus leads to a change in the probability or strength of the response to that stimulus. There is no association of one type of stimulus with another, rather it is a generalized response to the environment.
database_cross_reference: ISBN:0582227089

habituation
type: Class
subclass of: nonassociative learning
definition: A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented.
database_cross_reference: Wikipedia:Habituation
has_obo_namespace: biological_process
id: GO:0046959

Axiom
annotated source: habituation
annotated property: definition
annotated target: A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented.
database_cross_reference: ISBN:0582227089

sensitization
type: Class
subclass of: nonassociative learning
definition: An increased in a behavioral response to a repeated stimulus. For example, a shock to the tail of the marine snail Aplysia, to which the snail responds by withdrawing its gill, will result in increased gill withdrawal the next time the skin is touched.
database_cross_reference: Wikipedia:Sensitization
has_obo_namespace: biological_process
id: GO:0046960

Axiom
annotated source: sensitization
annotated property: definition
annotated target: An increased in a behavioral response to a repeated stimulus. For example, a shock to the tail of the marine snail Aplysia, to which the snail responds by withdrawing its gill, will result in increased gill withdrawal the next time the skin is touched.
database_cross_reference: ISBN:0582227089

regulation of response to osmotic stress
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: response to osmotic stress
subclass of: GO_0080134
subclass of: Restriction
  on property: regulates
  some values from: response to osmotic stress
definition: Any process that modulates the rate or extent of the response to osmotic stress.
has_obo_namespace: biological_process
id: GO:0047484

Axiom
annotated source: regulation of response to osmotic stress
annotated property: definition
annotated target: Any process that modulates the rate or extent of the response to osmotic stress.
database_cross_reference: GOC:ai

receptor ligand activity
type: Class
subclass of: signaling receptor binding
subclass of: signaling receptor activator activity
subclass of: Restriction
  on property: part of
  some values from: signal transduction
definition: The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same, or different, cell that expresses the receptor. Ligands may diffuse extracellularly from their point of origin to the receiving cell, or remain attached to an adjacent cell surface (e.g. Notch ligands).
IAO_0000233: https://github.com/geneontology/go-ontology/issues/14220
created by: midori
creation date: 2010-09-13T04:51:59Z
has_alternative_id: GO:0071884
has_broad_synonym: receptor agonist activity
has_exact_synonym: signaling molecule
has_exact_synonym: signaling receptor ligand activity
has_narrow_synonym: vitamin D receptor activator activity
has_obo_namespace: molecular_function
id: GO:0048018
in_subset: goslim chembl
in_subset: goslim drosophila
comment: Definition discussed in https://github.com/geneontology/go-ontology/issues/14220

Axiom
annotated source: receptor ligand activity
annotated property: definition
annotated target: The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same, or different, cell that expresses the receptor. Ligands may diffuse extracellularly from their point of origin to the receiving cell, or remain attached to an adjacent cell surface (e.g. Notch ligands).
database_cross_reference: GOC:kv
database_cross_reference: GOC:molecular_function_refactoring
database_cross_reference: GOC:pdt

Axiom
annotated source: receptor ligand activity
annotated property: has_broad_synonym
annotated target: receptor agonist activity
database_cross_reference: GOC:molecular_function_refactoring

apoplast
type: Class
subclass of: extracellular region
definition: The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it.
database_cross_reference: Wikipedia:Apoplast
has_obo_namespace: cellular_component
id: GO:0048046

Axiom
annotated source: apoplast
annotated property: definition
annotated target: The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it.
database_cross_reference: GOC:jid

autophagic cell death
type: Class
equivalent class: Class
  intersection of: programmed cell death
  intersection of: Restriction
    on property: has part
    some values from: macroautophagy
subclass of: programmed cell death
subclass of: Restriction
  on property: has part
  some values from: macroautophagy
definition: A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells.
has_broad_synonym: autophagic death
has_broad_synonym: programmed cell death by autophagy
has_exact_synonym: programmed cell death by macroautophagy
has_obo_namespace: biological_process
has_related_synonym: autosis
has_related_synonym: type II programmed cell death
id: GO:0048102
comment: The precise nature of autophagic cell death is still being debated, and the link between autophagy and cell death unclear. As autophagy is often induced under conditions of stress that could also lead to cell death, there has been a propagation of the idea that autophagy can act as a cell death mechanism; but others suggest that autophagy may simply be an attempt of dying cells to adapt to lethal stress rather than a mechanism to execute a cell death program. Further studies are required to resolve this controversy (see e.g. PMID:22082964, PMID:22052193, PMID:25236395). In the meantime, curators should carefully examine the experimental evidence presented in papers concerning autophagic cell death, and annotate accordingly. Recently, an instance of autophagic cell death, termed autosis, was discovered that relies on the plasma membrane Na+/K+-ATPase. Autosis was observed in vivo in the brain of rats subjected to an ischemic insult. It's still unclear if all cases of autophagic cell death require the Na+/K+-ATPase or not.

Axiom
annotated source: autophagic cell death
annotated property: definition
annotated target: A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells.
database_cross_reference: GOC:autophagy
database_cross_reference: GOC:mah
database_cross_reference: GOC:mtg_apoptosis
database_cross_reference: PMID:18846107
database_cross_reference: PMID:23347517

Axiom
annotated source: autophagic cell death
annotated property: has_broad_synonym
annotated target: programmed cell death by autophagy
database_cross_reference: GOC:pr

Axiom
annotated source: autophagic cell death
annotated property: has_exact_synonym
annotated target: programmed cell death by macroautophagy
database_cross_reference: GOC:cjm

Axiom
annotated source: autophagic cell death
annotated property: has_related_synonym
annotated target: autosis
database_cross_reference: PMID:25236395

Axiom
annotated source: autophagic cell death
annotated property: has_related_synonym
annotated target: type II programmed cell death
database_cross_reference: GOC:sl

somatic stem cell division
type: Class
subclass of: stem cell division
definition: The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line.
has_exact_synonym: somatic stem cell renewal
has_obo_namespace: biological_process
id: GO:0048103

Axiom
annotated source: somatic stem cell division
annotated property: definition
annotated target: The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line.
database_cross_reference: GOC:jid
database_cross_reference: ISBN:0582227089

fibroblast proliferation
type: Class
subclass of: cell population proliferation
definition: The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population.
has_obo_namespace: biological_process
id: GO:0048144

Axiom
annotated source: fibroblast proliferation
annotated property: definition
annotated target: The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population.
database_cross_reference: GOC:jid

regulation of fibroblast proliferation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: fibroblast proliferation
subclass of: regulation of cell population proliferation
subclass of: Restriction
  on property: regulates
  some values from: fibroblast proliferation
definition: Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
has_obo_namespace: biological_process
id: GO:0048145

Axiom
annotated source: regulation of fibroblast proliferation
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
database_cross_reference: GOC:jid

positive regulation of fibroblast proliferation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: fibroblast proliferation
subclass of: positive regulation of cell population proliferation
subclass of: regulation of fibroblast proliferation
subclass of: Restriction
  on property: positively regulates
  some values from: fibroblast proliferation
definition: Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
has_exact_synonym: up regulation of fibroblast proliferation
has_exact_synonym: up-regulation of fibroblast proliferation
has_exact_synonym: upregulation of fibroblast proliferation
has_narrow_synonym: activation of fibroblast proliferation
has_narrow_synonym: stimulation of fibroblast proliferation
has_obo_namespace: biological_process
id: GO:0048146

Axiom
annotated source: positive regulation of fibroblast proliferation
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
database_cross_reference: GOC:jid

negative regulation of fibroblast proliferation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: fibroblast proliferation
subclass of: negative regulation of cell population proliferation
subclass of: regulation of fibroblast proliferation
subclass of: Restriction
  on property: negatively regulates
  some values from: fibroblast proliferation
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
has_exact_synonym: down regulation of fibroblast proliferation
has_exact_synonym: down-regulation of fibroblast proliferation
has_exact_synonym: downregulation of fibroblast proliferation
has_narrow_synonym: inhibition of fibroblast proliferation
has_obo_namespace: biological_process
id: GO:0048147

Axiom
annotated source: negative regulation of fibroblast proliferation
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
database_cross_reference: GOC:jid

Golgi vesicle transport
type: Class
subclass of: vesicle-mediated transport
definition: The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles.
has_obo_namespace: biological_process
has_related_synonym: Golgi-derived vesicle transport
id: GO:0048193
in_subset: goslim yeast

Axiom
annotated source: Golgi vesicle transport
annotated property: definition
annotated target: The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles.
database_cross_reference: GOC:jid
database_cross_reference: ISBN:0716731363
database_cross_reference: PMID:10219233

vesicle targeting, to, from or within Golgi
type: Class
subclass of: vesicle targeting
subclass of: Restriction
  on property: part of
  some values from: Golgi vesicle transport
definition: The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation.
has_exact_synonym: Golgi vesicle targeting
has_narrow_synonym: dictyosome vesicle targeting
has_narrow_synonym: vesicle targeting, to, from or within dictyosome
has_obo_namespace: biological_process
id: GO:0048199

Axiom
annotated source: vesicle targeting, to, from or within Golgi
annotated property: definition
annotated target: The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation.
database_cross_reference: GOC:jid
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0716731363
database_cross_reference: PMID:10219233

regulation of vesicle targeting, to, from or within Golgi
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: vesicle targeting, to, from or within Golgi
subclass of: GO_0060341
subclass of: GO_0060627
subclass of: Restriction
  on property: regulates
  some values from: vesicle targeting, to, from or within Golgi
definition: Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus.
has_exact_synonym: regulation of Golgi vesicle targeting
has_obo_namespace: biological_process
id: GO:0048209

Axiom
annotated source: regulation of vesicle targeting, to, from or within Golgi
annotated property: definition
annotated target: Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus.
database_cross_reference: GOC:jid
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0716731363
database_cross_reference: PMID:10219233

male gamete generation
type: Class
subclass of: gamete generation
definition: Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction.
has_obo_namespace: biological_process
id: GO:0048232

Axiom
annotated source: male gamete generation
annotated property: definition
annotated target: Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jid

rough endoplasmic reticulum lumen
type: Class
equivalent class: Class
  intersection of: membrane-enclosed lumen
  intersection of: Restriction
    on property: part of
    some values from: rough endoplasmic reticulum
subclass of: endoplasmic reticulum lumen
subclass of: Restriction
  on property: part of
  some values from: rough endoplasmic reticulum
definition: The volume enclosed by the membranes of the rough endoplasmic reticulum.
database_cross_reference: NIF_Subcellular:sao1819509473
has_exact_synonym: RER lumen
has_exact_synonym: rough ER lumen
has_obo_namespace: cellular_component
id: GO:0048237

Axiom
annotated source: rough endoplasmic reticulum lumen
annotated property: definition
annotated target: The volume enclosed by the membranes of the rough endoplasmic reticulum.
database_cross_reference: GOC:jid

smooth endoplasmic reticulum lumen
type: Class
equivalent class: Class
  intersection of: membrane-enclosed lumen
  intersection of: Restriction
    on property: part of
    some values from: smooth endoplasmic reticulum
subclass of: endoplasmic reticulum lumen
subclass of: Restriction
  on property: part of
  some values from: smooth endoplasmic reticulum
definition: The volume enclosed by the membranes of the smooth endoplasmic reticulum.
database_cross_reference: NIF_Subcellular:sao927884761
has_exact_synonym: SER lumen
has_exact_synonym: smooth ER lumen
has_obo_namespace: cellular_component
id: GO:0048238

Axiom
annotated source: smooth endoplasmic reticulum lumen
annotated property: definition
annotated target: The volume enclosed by the membranes of the smooth endoplasmic reticulum.
database_cross_reference: GOC:jid

organelle fission
type: Class
subclass of: organelle organization
definition: The creation of two or more organelles by division of one organelle.
has_obo_namespace: biological_process
id: GO:0048285
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: organelle fission
annotated property: definition
annotated target: The creation of two or more organelles by division of one organelle.
database_cross_reference: GOC:jid

cell development
type: Class
subclass of: anatomical structure development
subclass of: cellular developmental process
subclass of: Restriction
  on property: part of
  some values from: cell differentiation
definition: The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
has_obo_namespace: biological_process
has_related_synonym: terminal differentiation
id: GO:0048468
in_subset: goslim candida

Axiom
annotated source: cell development
annotated property: definition
annotated target: The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
database_cross_reference: GOC:go_curators

Axiom
annotated source: cell development
annotated property: has_related_synonym
annotated target: terminal differentiation
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

cell maturation
type: Class
subclass of: cellular developmental process
subclass of: GO_0071695
subclass of: Restriction
  on property: part of
  some values from: cell development
definition: A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state.
has_obo_namespace: biological_process
has_related_synonym: functional differentiation
id: GO:0048469
in_subset: goslim pir

Axiom
annotated source: cell maturation
annotated property: definition
annotated target: A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state.
database_cross_reference: GOC:go_curators

Axiom
annotated source: cell maturation
annotated property: has_related_synonym
annotated target: functional differentiation
database_cross_reference: GOC:dph

oogenesis
type: Class
subclass of: germ cell development
subclass of: female gamete generation
definition: The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
has_alternative_id: GO:0009993
has_alternative_id: GO:0048157
database_cross_reference: Wikipedia:Oogenesis
has_exact_synonym: ovum development
has_obo_namespace: biological_process
id: GO:0048477

Axiom
annotated source: oogenesis
annotated property: definition
annotated target: The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
database_cross_reference: GOC:kmv
database_cross_reference: GOC:mtg_sensu
database_cross_reference: GOC:pr

Axiom
annotated source: oogenesis
annotated property: has_exact_synonym
annotated target: ovum development
has_synonym_type: Systematic synonym

rhythmic process
type: Class
subclass of: biological_process
definition: Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism.
has_obo_namespace: biological_process
has_related_synonym: rhythm
id: GO:0048511
in_subset: goslim pir

Axiom
annotated source: rhythmic process
annotated property: definition
annotated target: Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism.
database_cross_reference: GOC:jid

circadian behavior
type: Class
subclass of: rhythmic behavior
subclass of: circadian rhythm
definition: The specific behavior of an organism that recurs with a regularity of approximately 24 hours.
has_exact_synonym: circadian rhythm behavior
has_obo_namespace: biological_process
id: GO:0048512

Axiom
annotated source: circadian behavior
annotated property: definition
annotated target: The specific behavior of an organism that recurs with a regularity of approximately 24 hours.
database_cross_reference: GOC:bf
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:pr

animal organ development
type: Class
subclass of: anatomical structure development
subclass of: Restriction
  on property: part of
  some values from: system development
definition: Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
database_cross_reference: Wikipedia:Organogenesis
has_exact_synonym: development of an organ
has_exact_synonym: organogenesis
has_obo_namespace: biological_process
id: GO:0048513

Axiom
annotated source: animal organ development
annotated property: definition
annotated target: Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jid

blood vessel morphogenesis
type: Class
subclass of: tube morphogenesis
subclass of: Restriction
  on property: part of
  some values from: blood vessel development
definition: The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.
has_obo_namespace: biological_process
id: GO:0048514

Axiom
annotated source: blood vessel morphogenesis
annotated property: definition
annotated target: The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.
database_cross_reference: GOC:jid

spermatid differentiation
type: Class
subclass of: developmental process involved in reproduction
subclass of: cellular process involved in reproduction in multicellular organism
subclass of: cell differentiation
subclass of: Restriction
  on property: part of
  some values from: spermatogenesis
definition: The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
has_exact_synonym: spermatid cell differentiation
has_obo_namespace: biological_process
id: GO:0048515

Axiom
annotated source: spermatid differentiation
annotated property: definition
annotated target: The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jid

positive regulation of biological process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: biological_process
subclass of: GO_0050789
subclass of: Restriction
  on property: positively regulates
  some values from: biological_process
definition: Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
has_alternative_id: GO:0043119
has_exact_synonym: positive regulation of physiological process
has_exact_synonym: up regulation of biological process
has_exact_synonym: up-regulation of biological process
has_exact_synonym: upregulation of biological process
has_narrow_synonym: activation of biological process
has_narrow_synonym: stimulation of biological process
has_obo_namespace: biological_process
id: GO:0048518
in_subset: gocheck do not annotate

Axiom
annotated source: positive regulation of biological process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
database_cross_reference: GOC:jid

negative regulation of biological process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: biological_process
subclass of: GO_0050789
subclass of: Restriction
  on property: negatively regulates
  some values from: biological_process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
has_alternative_id: GO:0043118
has_exact_synonym: down regulation of biological process
has_exact_synonym: down-regulation of biological process
has_exact_synonym: downregulation of biological process
has_exact_synonym: negative regulation of physiological process
has_narrow_synonym: inhibition of biological process
has_obo_namespace: biological_process
id: GO:0048519
in_subset: gocheck do not annotate

Axiom
annotated source: negative regulation of biological process
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
database_cross_reference: GOC:jid

positive regulation of behavior
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: behavior
subclass of: positive regulation of response to stimulus
subclass of: GO_0050795
subclass of: Restriction
  on property: positively regulates
  some values from: behavior
definition: Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.
has_exact_synonym: up regulation of behavior
has_exact_synonym: up-regulation of behavior
has_exact_synonym: upregulation of behavior
has_narrow_synonym: activation of behavior
has_narrow_synonym: stimulation of behavior
has_obo_namespace: biological_process
id: GO:0048520

Axiom
annotated source: positive regulation of behavior
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.
database_cross_reference: GOC:jid
database_cross_reference: GOC:pr

negative regulation of behavior
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: behavior
subclass of: negative regulation of response to stimulus
subclass of: GO_0050795
subclass of: Restriction
  on property: negatively regulates
  some values from: behavior
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.
has_exact_synonym: down regulation of behavior
has_exact_synonym: down-regulation of behavior
has_exact_synonym: downregulation of behavior
has_narrow_synonym: inhibition of behavior
has_obo_namespace: biological_process
id: GO:0048521

Axiom
annotated source: negative regulation of behavior
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.
database_cross_reference: GOC:jid
database_cross_reference: GOC:pr

positive regulation of cellular process
type: Class
equivalent class: Class
  intersection of: GO_0065007
  intersection of: Restriction
    on property: positively regulates
    some values from: cellular process
subclass of: positive regulation of biological process
subclass of: GO_0050794
subclass of: Restriction
  on property: positively regulates
  some values from: cellular process
definition: Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
has_alternative_id: GO:0051242
has_exact_synonym: positive regulation of cellular physiological process
has_exact_synonym: up regulation of cellular process
has_exact_synonym: up-regulation of cellular process
has_exact_synonym: upregulation of cellular process
has_narrow_synonym: activation of cellular process
has_narrow_synonym: stimulation of cellular process
has_obo_namespace: biological_process
id: GO:0048522

Axiom
annotated source: positive regulation of cellular process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
database_cross_reference: GOC:jid

negative regulation of cellular process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cellular process
subclass of: negative regulation of biological process
subclass of: GO_0050794
subclass of: Restriction
  on property: negatively regulates
  some values from: cellular process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
has_alternative_id: GO:0051243
has_exact_synonym: down regulation of cellular process
has_exact_synonym: down-regulation of cellular process
has_exact_synonym: downregulation of cellular process
has_exact_synonym: negative regulation of cellular physiological process
has_narrow_synonym: inhibition of cellular process
has_obo_namespace: biological_process
id: GO:0048523

Axiom
annotated source: negative regulation of cellular process
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
database_cross_reference: GOC:jid

hematopoietic or lymphoid organ development
type: Class
subclass of: animal organ development
subclass of: Restriction
  on property: part of
  some values from: immune system development
definition: The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation.
has_exact_synonym: haematopoietic or lymphoid organ development
has_exact_synonym: haemopoietic or lymphoid organ development
has_exact_synonym: hemopoietic or lymphoid organ development
has_obo_namespace: biological_process
id: GO:0048534

Axiom
annotated source: hematopoietic or lymphoid organ development
annotated property: definition
annotated target: The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation.
database_cross_reference: GOC:add
database_cross_reference: GOC:rl
database_cross_reference: ISBN:0781735149

response to steroid hormone
type: Class
subclass of: response to hormone
subclass of: response to organic cyclic compound
subclass of: response to lipid
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.
has_exact_synonym: response to steroid hormone stimulus
has_obo_namespace: biological_process
id: GO:0048545

Axiom
annotated source: response to steroid hormone
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.
database_cross_reference: GOC:go_curators

Axiom
annotated source: response to steroid hormone
annotated property: has_exact_synonym
annotated target: response to steroid hormone stimulus
database_cross_reference: GOC:dos

regulation of response to stimulus
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: GO_0050896
subclass of: GO_0050789
subclass of: Restriction
  on property: regulates
  some values from: GO_0050896
definition: Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
has_obo_namespace: biological_process
id: GO:0048583
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: regulation of response to stimulus
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
database_cross_reference: GOC:jid

positive regulation of response to stimulus
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: GO_0050896
subclass of: positive regulation of biological process
subclass of: regulation of response to stimulus
subclass of: Restriction
  on property: positively regulates
  some values from: GO_0050896
definition: Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
has_exact_synonym: up regulation of response to stimulus
has_exact_synonym: up-regulation of response to stimulus
has_exact_synonym: upregulation of response to stimulus
has_narrow_synonym: activation of response to stimulus
has_narrow_synonym: stimulation of response to stimulus
has_obo_namespace: biological_process
id: GO:0048584
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: positive regulation of response to stimulus
annotated property: definition
annotated target: Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
database_cross_reference: GOC:jid

negative regulation of response to stimulus
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: GO_0050896
subclass of: negative regulation of biological process
subclass of: regulation of response to stimulus
subclass of: Restriction
  on property: negatively regulates
  some values from: GO_0050896
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
has_exact_synonym: down regulation of response to stimulus
has_exact_synonym: down-regulation of response to stimulus
has_exact_synonym: downregulation of response to stimulus
has_narrow_synonym: inhibition of response to stimulus
has_obo_namespace: biological_process
id: GO:0048585
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: negative regulation of response to stimulus
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
database_cross_reference: GOC:jid

developmental growth
type: Class
subclass of: developmental process
subclass of: growth
definition: The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.
has_obo_namespace: biological_process
id: GO:0048589

Axiom
annotated source: developmental growth
annotated property: definition
annotated target: The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.
database_cross_reference: GOC:go_curators

oocyte development
type: Class
subclass of: germ cell development
subclass of: Restriction
  on property: part of
  some values from: oocyte differentiation
definition: The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
has_obo_namespace: biological_process
id: GO:0048599

Axiom
annotated source: oocyte development
annotated property: definition
annotated target: The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
database_cross_reference: GOC:go_curators

multicellular organismal reproductive process
type: Class
subclass of: reproductive process
subclass of: Restriction
  on property: part of
  some values from: multicellular organism reproduction
definition: The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs.
has_broad_synonym: organismal reproductive process
has_exact_synonym: reproductive process in a multicellular organism
has_obo_namespace: biological_process
id: GO:0048609

Axiom
annotated source: multicellular organismal reproductive process
annotated property: definition
annotated target: The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jid
database_cross_reference: GOC:tb

regulation of developmental growth
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: developmental growth
subclass of: regulation of growth
subclass of: GO_0050793
subclass of: Restriction
  on property: regulates
  some values from: developmental growth
definition: Any process that modulates the frequency, rate or extent of developmental growth.
has_obo_namespace: biological_process
id: GO:0048638

Axiom
annotated source: regulation of developmental growth
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of developmental growth.
database_cross_reference: GOC:go_curators

positive regulation of developmental growth
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: developmental growth
subclass of: positive regulation of growth
subclass of: regulation of developmental growth
subclass of: GO_0051094
subclass of: Restriction
  on property: positively regulates
  some values from: developmental growth
definition: Any process that activates, maintains or increases the rate of developmental growth.
has_exact_synonym: up regulation of developmental growth
has_exact_synonym: up-regulation of developmental growth
has_exact_synonym: upregulation of developmental growth
has_narrow_synonym: activation of developmental growth
has_narrow_synonym: stimulation of developmental growth
has_obo_namespace: biological_process
id: GO:0048639

Axiom
annotated source: positive regulation of developmental growth
annotated property: definition
annotated target: Any process that activates, maintains or increases the rate of developmental growth.
database_cross_reference: GOC:go_curators

negative regulation of developmental growth
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: developmental growth
subclass of: negative regulation of growth
subclass of: regulation of developmental growth
subclass of: GO_0051093
subclass of: Restriction
  on property: negatively regulates
  some values from: developmental growth
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth.
has_exact_synonym: down regulation of developmental growth
has_exact_synonym: down-regulation of developmental growth
has_exact_synonym: downregulation of developmental growth
has_narrow_synonym: inhibition of developmental growth
has_obo_namespace: biological_process
id: GO:0048640

Axiom
annotated source: negative regulation of developmental growth
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth.
database_cross_reference: GOC:go_curators

anatomical structure formation involved in morphogenesis
type: Class
subclass of: developmental process
subclass of: Restriction
  on property: part of
  some values from: anatomical structure morphogenesis
definition: The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
has_exact_synonym: formation of an anatomical structure involved in morphogenesis
has_obo_namespace: biological_process
id: GO:0048646
in_subset: goslim chembl
in_subset: goslim generic
comment: Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense.

Axiom
annotated source: anatomical structure formation involved in morphogenesis
annotated property: definition
annotated target: The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jid
database_cross_reference: GOC:tb

Axiom
annotated source: anatomical structure formation involved in morphogenesis
annotated property: has_exact_synonym
annotated target: formation of an anatomical structure involved in morphogenesis
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

neuron development
type: Class
subclass of: cell development
subclass of: Restriction
  on property: part of
  some values from: neuron differentiation
definition: The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
has_obo_namespace: biological_process
id: GO:0048666

Axiom
annotated source: neuron development
annotated property: definition
annotated target: The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
database_cross_reference: GOC:dph

generation of neurons
type: Class
subclass of: neurogenesis
definition: The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons.
has_exact_synonym: neuron generation
has_obo_namespace: biological_process
id: GO:0048699

Axiom
annotated source: generation of neurons
annotated property: definition
annotated target: The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons.
database_cross_reference: GOC:nln

system development
type: Class
subclass of: anatomical structure development
subclass of: Restriction
  on property: part of
  some values from: multicellular organism development
definition: The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
has_obo_namespace: biological_process
id: GO:0048731
in_subset: goslim mouse

Axiom
annotated source: system development
annotated property: definition
annotated target: The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jid

anatomical structure development
type: Class
subclass of: developmental process
definition: The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
has_exact_synonym: development of an anatomical structure
has_obo_namespace: biological_process
id: GO:0048856
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim plant

Axiom
annotated source: anatomical structure development
annotated property: definition
annotated target: The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
database_cross_reference: GO_REF:0000021

cellular developmental process
type: Class
subclass of: cellular process
subclass of: developmental process
definition: A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.
has_obo_namespace: biological_process
id: GO:0048869

Axiom
annotated source: cellular developmental process
annotated property: definition
annotated target: A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.
database_cross_reference: GOC:isa_complete

cell motility
type: Class
subclass of: movement of cell or subcellular component
subclass of: locomotion
subclass of: Restriction
  on property: part of
  some values from: GO_0051674
definition: Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
has_exact_synonym: cell locomotion
has_exact_synonym: movement of a cell
has_obo_namespace: biological_process
has_related_synonym: cell movement
id: GO:0048870
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic

Axiom
annotated source: cell motility
annotated property: definition
annotated target: Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
database_cross_reference: GOC:dgh
database_cross_reference: GOC:dph
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:mlg

homeostasis of number of cells
type: Class
subclass of: homeostatic process
definition: Any biological process involved in the maintenance of the steady-state number of cells within a population of cells.
has_exact_synonym: cell population homeostasis
has_exact_synonym: homeostasis of cell number
has_obo_namespace: biological_process
id: GO:0048872

Axiom
annotated source: homeostasis of number of cells
annotated property: definition
annotated target: Any biological process involved in the maintenance of the steady-state number of cells within a population of cells.
database_cross_reference: GOC:isa_complete

Axiom
annotated source: homeostasis of number of cells
annotated property: has_exact_synonym
annotated target: homeostasis of cell number
database_cross_reference: GOC:dph

chemical homeostasis
type: Class
subclass of: homeostatic process
definition: Any biological process involved in the maintenance of an internal steady state of a chemical.
has_obo_namespace: biological_process
id: GO:0048878
in_subset: goslim drosophila

Axiom
annotated source: chemical homeostasis
annotated property: definition
annotated target: Any biological process involved in the maintenance of an internal steady state of a chemical.
database_cross_reference: GOC:isa_complete

epithelial cell proliferation
type: Class
subclass of: cell population proliferation
definition: The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances.
has_obo_namespace: biological_process
id: GO:0050673

Axiom
annotated source: epithelial cell proliferation
annotated property: definition
annotated target: The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances.
database_cross_reference: ISBN:0721662544

regulation of epithelial cell proliferation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: epithelial cell proliferation
subclass of: regulation of cell population proliferation
subclass of: Restriction
  on property: regulates
  some values from: epithelial cell proliferation
definition: Any process that modulates the frequency, rate or extent of epithelial cell proliferation.
has_obo_namespace: biological_process
id: GO:0050678

Axiom
annotated source: regulation of epithelial cell proliferation
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of epithelial cell proliferation.
database_cross_reference: GOC:ai

positive regulation of epithelial cell proliferation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: epithelial cell proliferation
subclass of: positive regulation of cell population proliferation
subclass of: regulation of epithelial cell proliferation
subclass of: Restriction
  on property: positively regulates
  some values from: epithelial cell proliferation
definition: Any process that activates or increases the rate or extent of epithelial cell proliferation.
has_exact_synonym: up regulation of epithelial cell proliferation
has_exact_synonym: up-regulation of epithelial cell proliferation
has_exact_synonym: upregulation of epithelial cell proliferation
has_narrow_synonym: activation of epithelial cell proliferation
has_narrow_synonym: stimulation of epithelial cell proliferation
has_obo_namespace: biological_process
id: GO:0050679

Axiom
annotated source: positive regulation of epithelial cell proliferation
annotated property: definition
annotated target: Any process that activates or increases the rate or extent of epithelial cell proliferation.
database_cross_reference: GOC:ai

negative regulation of epithelial cell proliferation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: epithelial cell proliferation
subclass of: negative regulation of cell population proliferation
subclass of: regulation of epithelial cell proliferation
subclass of: Restriction
  on property: negatively regulates
  some values from: epithelial cell proliferation
definition: Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
has_exact_synonym: down regulation of epithelial cell proliferation
has_exact_synonym: down-regulation of epithelial cell proliferation
has_exact_synonym: downregulation of epithelial cell proliferation
has_narrow_synonym: inhibition of epithelial cell proliferation
has_obo_namespace: biological_process
id: GO:0050680

Axiom
annotated source: negative regulation of epithelial cell proliferation
annotated property: definition
annotated target: Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
database_cross_reference: GOC:ai

regulation of protein secretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: protein secretion
subclass of: regulation of peptide secretion
subclass of: GO_0051223
subclass of: GO_1903530
subclass of: Restriction
  on property: regulates
  some values from: protein secretion
definition: Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell.
has_obo_namespace: biological_process
id: GO:0050708

Axiom
annotated source: regulation of protein secretion
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell.
database_cross_reference: GOC:ai

negative regulation of protein secretion
type: Class
equivalent class: Class
  intersection of: biological_process
subclass of: negative regulation of peptide secretion
subclass of: regulation of protein secretion
subclass of: GO_0051224
subclass of: GO_1903531
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.
has_exact_synonym: down regulation of protein secretion
has_exact_synonym: down-regulation of protein secretion
has_exact_synonym: downregulation of protein secretion
has_narrow_synonym: inhibition of protein secretion
has_obo_namespace: biological_process
id: GO:0050709