format-version: 1.2 ontology: uberon/subsets/immune-minimal owl-axioms: Prefix(owl:=)\nPrefix(rdf:=)\nPrefix(xml:=)\nPrefix(xsd:=)\nPrefix(rdfs:=)\n\n\nOntology(\nDeclaration(Class())\nDeclaration(Class())\nDeclaration(ObjectProperty())\n\n############################\n# Classes\n############################\n\n# Class: ()\n\nEquivalentClasses( ObjectSomeValuesFrom( ))\n\n# Class: owl:Nothing (owl:Nothing)\n\nSubClassOf(owl:Nothing owl:Nothing)\n\n\n) [Term] id: BFO:0000002 name: continuant relationship: part_of BFO:0000002 ! continuant [Term] id: BFO:0000004 name: independent continuant is_a: BFO:0000002 ! continuant relationship: part_of BFO:0000004 ! independent continuant [Term] id: BFO:0000040 name: material entity is_a: BFO:0000004 ! independent continuant [Term] id: CL:0000041 name: mature eosinophil namespace: cell def: "A fully differentiated eosinophil, a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Cells are also differentiated from other granulocytes by a small nuclear-to-cytoplasm ratio (1:3). This cell type is CD49d-positive." [] comment: Eosinophils are CD125-positive (IL-5R), GM-CSFR-positive, IL-3R-positive, VLA4-positive. They can also express MHC Class I & II, CD4, CD9, CD11a, CD11b, CD11c, CD13, CD15, CD16, CD17, CD18, CD24, CD25,CD28, CD29, CD32, CD33, CD35, CD37, CD39, CD43, CD44, CD45, CD45RB, CD45RO, CD46, CD47, CD48, CD49d, CD49f, CD50, CD52, CD53, CD54, CD55, CD58, CD59, CD62L, CD63, CD65, CD66, CD69, CD71, CD76, CD80, CD81, CD82, CD86, CD87, CD88, CD89, CD92, CD95, CD97, CD98, CD99, CD100, CD101, CD116, CD117, CD119, CD120, CD123, CD124, CD125, CD131, CD137, CD139, CD148, CD149, CD151, CD153, CD156, CD162, CD161, CD162, CD165, CD174, CD182, CD183, CD191, CD192, CD193, CD196, CD213, IL9R, ad integrin, beta-7 integrin, FceRI, IL13Ra1, TGFbR, PAFR, LTB4R, C3aR, CystLT1R, CystLT2R, fMLPR, CRTH2 (PGD2 receptor), histamine 4R, IDO, KYN, PAR-2, Siglec-8, Siglec-10, LIR1, LIR2, LIR3, LIR7, TLR7, TLR8, and VLA-4. Eosinophils can also secrete CXCL1, eotaxin-1, GM-CSF, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13, IL-16, IL-18, IFN-gamma, LTC4, MIP-1alpha, NGF, PAF, RANTES, substance P, TGF-alpha, TGF-beta, TNF-alpha, and VIP. synonym: "mature eosinocyte" EXACT [] synonym: "mature eosinophil leucocyte" EXACT [] synonym: "mature eosinophil leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] is_a: CL:0000145 ! professional antigen presenting cell is_a: CL:0000771 ! eosinophil property_value: IAO:0000116 "The status of eosinophils as true professional antigen presenting cells is unclear, despite their ability to present exogenous peptides and peptides processed from exogenous proteins (in certain studies) via MHC Class II and activate T cells. Per the equivalence axioms, 'eosinophil' is reasoned to be a subclass of 'professional antigen presenting cell', though the role of eosinophils as such in the body may be limited." xsd:string [Term] id: CL:0000043 name: mature basophil namespace: cell alt_id: CL:0000739 def: "A fully differentiated basophil, a granular leukocyte with an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation." [] comment: Mature basophils are also capable of producing IL-3, IL-5, IL-6, IL-8, IL-13, IL-25, CCL22, tslp, vegf, and LTC4. synonym: "mature basophil leucocyte" EXACT [] synonym: "mature basophil leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] xref: BTO:0001026 xref: CALOHA:TS-0688 is_a: CL:0000767 ! basophil [Term] id: CL:0000084 name: T cell namespace: cell alt_id: CL:0000804 alt_id: CL:0000812 def: "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [] synonym: "immature T cell" RELATED [] synonym: "mature T cell" RELATED [] synonym: "T lymphocyte" EXACT [] synonym: "T-cell" EXACT [] synonym: "T-lymphocyte" EXACT [] xref: BTO:0000782 xref: CALOHA:TS-1001 xref: FMA:62870 xref: VHOG:0001479 is_a: CL:0000542 ! lymphocyte [Term] id: CL:0000091 name: Kupffer cell namespace: cell def: "A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system." [] comment: Markers: Mouse: F4/80+, CD11b-low, CD68+, sialoadhesin+, CD163/SRCR+; role or process: immune, antigen-presentation, clearance of senescent erythrocytes, iron metabolism. Kupffer cells are also reportedly C3aR-positive, CD14-low, CD54-positive, CD88-positive, and CD284-positive. They are also capable of producing IL-1, IL-6, TNF-alpha, nitric oxide, PGD2, PGE2, PGF2alpha, and TXA2. synonym: "hepatic macrophage" EXACT [] synonym: "littoral cell of hepatic sinusoid" EXACT [] synonym: "liver macrophage" EXACT [] synonym: "macrophagocytus stellatus" EXACT [] synonym: "stellate cell of von Kupffer" EXACT [] synonym: "von Kupffer cell" EXACT [] xref: BTO:0000685 xref: FMA:14656 is_a: CL:0000864 ! tissue-resident macrophage [Term] id: CL:0000092 name: osteoclast namespace: cell def: "A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive." [] comment: Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid. synonym: "chondroclast" RELATED [] xref: BTO:0000968 xref: CALOHA:TS-0721 xref: FMA:66781 is_a: CL:0000766 ! myeloid leukocyte [Term] id: CL:0000094 name: granulocyte namespace: cell def: "A leukocyte with abundant granules in the cytoplasm." [] synonym: "granular leucocyte" EXACT [] synonym: "granular leukocyte" EXACT [] synonym: "polymorphonuclear leukocyte" EXACT [] xref: BTO:0000539 xref: BTO:0001026 xref: CALOHA:TS-0422 xref: FMA:62854 is_a: CL:0000766 ! myeloid leukocyte [Term] id: CL:0000096 name: mature neutrophil namespace: cell def: "A fully differentiated neutrophil, a granular leukocyte having a nucleus with three to five lobes connected by slender threads, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. They are produced in bone marrow at a rate of 5e10-10e10/day and have a half-life of 6-8 hours. Neutrophils are CD15-positive, CD16-positive, CD32-positive, CD43-positive, CD181-positive, and CD182-positive." [] comment: Neutrophils are also capable of secreting GRO-alpha, IL-1beta, IL-1ra, IL-3, IL-12, IP-10, MIG, MIP-1alpha, MIP-1beta, TGF-beta, TNF-alpha, VEGF, and anti-microbial peptides. They can positively influence the chemotaxis of basophils, T-cells, monocytes, macrophages, dendritic cells, and other neutrophils. Neutrophils are also CD35-positive, CD64-positive, CD89-positive, CD184-positive, and fMLP receptor-positive Ly-6G-positive (mouse), TLR2-low, TLR4-low, and lineage-negative (CD2, CD3, CD5, CD9, CD19, CD36, CD49d, CD56, CD61, CD235a (glycophorin-A)). synonym: "mature neutrocyte" EXACT [] synonym: "mature neutrophil leucocyte" EXACT [] synonym: "mature neutrophil leukocyte" EXACT [] synonym: "mature neutrophilic leucocyte" EXACT [] synonym: "mature neutrophilic leukocyte" EXACT [] synonym: "PMN" EXACT [] synonym: "poly" BROAD [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] synonym: "polymorphonuclear neutrophil" EXACT [] synonym: "polynuclear neutrophilic leucocyte" EXACT [] synonym: "polynuclear neutrophilic leukocyte" EXACT [] xref: BTO:0003473 is_a: CL:0000775 ! neutrophil [Term] id: CL:0000097 name: mast cell namespace: cell def: "A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development." [] comment: Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5. synonym: "histaminocyte" EXACT [] synonym: "labrocyte" EXACT [] synonym: "mastocyte" EXACT [] synonym: "tissue basophil" RELATED [] xref: BTO:0000830 xref: CALOHA:TS-0603 xref: FMA:66784 is_a: CL:0000766 ! myeloid leukocyte [Term] id: CL:0000129 name: microglial cell namespace: cell def: "A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive." [] comment: Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive. synonym: "brain macrophage" BROAD [] synonym: "brain-resident macrophage" EXACT [] synonym: "hortega cells" EXACT [] synonym: "MF.microglia.CNS" RELATED [] synonym: "microglia" EXACT [] synonym: "microgliocyte" EXACT [] xref: BTO:0000078 xref: BTO:0000962 xref: FMA:54539 xref: FMA:54540 is_a: CL:0000878 ! central nervous system macrophage [Term] id: CL:0000145 name: professional antigen presenting cell namespace: cell def: "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." [] comment: Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells. synonym: "APC" BROAD [] is_a: CL:0000738 ! leukocyte [Term] id: CL:0000235 name: macrophage namespace: cell def: "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [] comment: Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid. synonym: "histiocyte" EXACT [] xref: BTO:0000801 xref: CALOHA:TS-0587 xref: FMA:63261 xref: FMA:83585 is_a: CL:0000145 ! professional antigen presenting cell is_a: CL:0000766 ! myeloid leukocyte [Term] id: CL:0000236 name: B cell namespace: cell def: "A lymphocyte of B lineage that is capable of B cell mediated immunity." [] def: "A lymphocyte of B lineage with the phenotype CD19-positive, CD20-positive, and capable of B cell mediated immunity." [] synonym: "B lymphocyte" EXACT [] synonym: "B-cell" EXACT [] synonym: "B-lymphocyte" EXACT [] xref: BTO:0000776 xref: CALOHA:TS-0068 xref: FMA:62869 xref: VHOG:0001480 is_a: CL:0000945 ! lymphocyte of B lineage [Term] id: CL:0000451 name: dendritic cell namespace: cell def: "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative)." [] synonym: "interdigitating cell" RELATED [] synonym: "veiled cell" RELATED [] xref: BTO:0002042 xref: CALOHA:TS-0194 xref: FMA:83036 is_a: CL:0000145 ! professional antigen presenting cell is_a: CL:0000842 ! mononuclear cell [Term] id: CL:0000453 name: Langerhans cell namespace: cell def: "Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000021 )(PMID:19243617). These cells are also CD1a-high, CD14-negative, CD207-positive (langerin), CD324-positive (E-cadherin), and DCIR-positive. They reside in the epidermis. synonym: "Langerhans' cell" EXACT [] synonym: "LC" EXACT [] xref: BTO:0000705 xref: CALOHA:TS-2375 xref: FMA:63072 is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 ! conventional dendritic cell [Term] id: CL:0000484 name: connective tissue type mast cell namespace: cell def: "Mast cell subtype whose granules contain both the serine proteases tryptase and chymase. These cells are primarily found in connective tissue, such as the peritoneal cavity, skin, and intestinal submucosa. Their development is T-cell independent." [] comment: They are CD88-positive. The cytoplasmic granules contain high levels of histamine and heparin (mouse) or major neutral proteases, tryptase, chymase, carboxypeptidase A, and cathepsin G (humans). Reportedly, they cannot produce leukotrienes (LTC4) and IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype. synonym: "MC(TC)" EXACT [] synonym: "MCTC" EXACT [] synonym: "TC mast cells" EXACT [] is_a: CL:0000097 ! mast cell [Term] id: CL:0000485 name: mucosal type mast cell namespace: cell def: "Mast cell subtype that contains only the serine protease trypase in its granules. These cells are primarily found in mucosal tissue, such as intestinal mucosa and alveoli. They depend upon T-cells for development of phenotype." [] comment: They are CD88-negative. The cytoplasmic granules contain low levels of histamine and high levels of chondroitin sulfate (mouse) or major neutral proteases and tryptase (humans). Additionally, they can produce leukotrienes (LTC4), IL-5, IL-6, and low levels of IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype. synonym: "MC(T)" EXACT [] synonym: "MCT" EXACT [] synonym: "T mast cells" EXACT [] is_a: CL:0000097 ! mast cell relationship: part_of UBERON:0001961 ! mucosa-associated lymphoid tissue [Term] id: CL:0000492 name: CD4-positive helper T cell namespace: cell def: "A CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions." [] synonym: "CD4-positive helper T lymphocyte" EXACT [] synonym: "CD4-positive helper T-cell" EXACT [] synonym: "CD4-positive helper T-lymphocyte" EXACT [] synonym: "CD4-positive T-helper cell" EXACT [] xref: CALOHA:TS-1146 xref: FMA:70572 is_a: CL:0000624 ! CD4-positive, alpha-beta T cell [Term] id: CL:0000542 name: lymphocyte namespace: cell def: "A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [] comment: Editors note: consider adding taxon constraint to vertebrata (PMID:18025161) xref: BTO:0000775 xref: CALOHA:TS-0583 xref: FMA:62863 xref: VHOG:0001535 is_a: CL:0000842 ! mononuclear cell [Term] id: CL:0000545 name: T-helper 1 cell namespace: cell def: "A CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'Th1 CD4+ T cell', but its logical definition includes additional known characteristics of T-helper 1 T cells. synonym: "helper T cell type 1" EXACT [] synonym: "T helper cells type 1" EXACT [] synonym: "T(H)-1 cell" EXACT [] synonym: "Th1 CD4+ T cell" EXACT [] synonym: "Th1 cell" EXACT [] synonym: "Th1 T cell" EXACT [] synonym: "Th1 T lymphocyte" EXACT [] synonym: "Th1 T-cell" EXACT [] synonym: "Th1 T-lymphocyte" EXACT [] xref: BTO:0001678 xref: FMA:84382 is_a: CL:0000492 ! CD4-positive helper T cell [Term] id: CL:0000546 name: T-helper 2 cell namespace: cell def: "A CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive, CXCR3-negative, CCR6-negative, and is capable of producing interleukin-4." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'non-Th1/Th17 CD4+ T cell' (see CL:0001051), but includes the additional necessary and sufficient conditions to allow classification as a T-helper 2 T cell. synonym: "helper T cell type 2" EXACT [] synonym: "T helper cells type 2" EXACT [] synonym: "T(H)-2 cell" EXACT [] synonym: "Th2 cell" EXACT [] synonym: "Th2 T cell" EXACT [] synonym: "Th2 T lymphocyte" EXACT [] synonym: "Th2 T-cell" EXACT [] synonym: "Th2 T-lymphocyte" EXACT [] xref: BTO:0001679 xref: FMA:84385 is_a: CL:0000492 ! CD4-positive helper T cell is_a: CL:0001051 ! CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell [Term] id: CL:0000556 name: megakaryocyte namespace: cell def: "A giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm." [] comment: Megakaryocytes are reportedly CD181-positive and CD182-positive. synonym: "megacaryocyte" EXACT [] synonym: "megalocaryocyte" EXACT [] synonym: "megalokaryocyte" EXACT [] xref: BTO:0000843 xref: CALOHA:TS-0611 xref: FMA:83555 is_a: CL:1001610 ! bone marrow hematopoietic cell [Term] id: CL:0000557 name: granulocyte monocyte progenitor cell namespace: cell def: "A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. synonym: "CFU-C , Colony forming unit in culture" BROAD [] synonym: "CFU-GM" EXACT [] synonym: "colony forming unit granulocyte macrophage" EXACT [] synonym: "GMP" EXACT [] synonym: "granulocyte-macrophage progenitor" EXACT [] synonym: "granulocyte/monocyte precursor" EXACT [] synonym: "granulocyte/monocyte progenitor" EXACT [] is_a: CL:1001610 ! bone marrow hematopoietic cell [Term] id: CL:0000560 name: band form neutrophil namespace: cell def: "A late neutrophilic metamyelocyte in which the nucleus is indented to more than half the distance to the farthest nuclear margin but in no area being condensed to a single filament. The nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature neutrophil. These cells are fMLP receptor-positive, CD11b-positive, CD35-negative, and CD49d-negative." [] comment: Found in the Band 1 fraction. synonym: "band" BROAD [] synonym: "band cell" BROAD [] synonym: "band form" BROAD [] synonym: "rod neutrophil" EXACT [] synonym: "stab cell" BROAD [] is_a: CL:0000096 ! mature neutrophil [Term] id: CL:0000576 name: monocyte namespace: cell def: "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." [] comment: Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid. xref: BTO:0000876 xref: CALOHA:TS-0638 xref: FMA:62864 is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000842 ! mononuclear cell [Term] id: CL:0000580 name: neutrophilic myelocyte namespace: cell def: "A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and neutrophil-specific granules has started. No nucleolus is present. This cell type is CD13-positive, CD16-negative, integrin alpha-M-positive, CD15-positive, CD33-positive, CD24-positive, C/EBP-a-positive, C/EBPe-positive, PU.1-positive, lactotransferrin-positive, myeloperoxidase-positive and NGAL-positive." [] comment: These cells are also CD15-positive, CD35-negative, CD49d-positive, and fMLP receptor-negative. They are found in the Band 2 fraction. xref: BTO:0003455 xref: FMA:83540 is_a: CL:0000776 ! immature neutrophil is_a: CL:0002087 ! nongranular leukocyte [Term] id: CL:0000581 name: peritoneal macrophage namespace: cell def: "A macrophage resident in the peritoneum under non-inflammatory conditions. Markers include F4/80-high, CD11b-high, CD68-positive, SIGNR1-positive, CD115-high, MHC-II-negative, and Dectin-1-positive." [] comment: Markers: Mouse: F4/80-high, CD11b-high, CD68+, SIGNR1+, Dectin-1+. xref: BTO:0001034 xref: FMA:83025 is_a: CL:0000864 ! tissue-resident macrophage [Term] id: CL:0000582 name: neutrophilic metamyelocyte namespace: cell def: "A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and the band form neutrophil. The protein synthesis seen in earlier stages decreases or stops; the nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare; and the cytoplasm becomes amphophilic like that of a mature granulocyte. This cell type is integrin alpha-M-positive, CD13-negative, CD15-positive, CD16-positive, CD33-positive, CD24-positive, fMLP receptor-negative and has expression of C/EBP-a, C/EBP-e, PU.1 transcription factor, lactotransferrin, myeloperoxidase and neutrophil gelatinase associated lipocalin." [] comment: These cells are also CD35-negative, CD49d-positive, and fMLP receptor-negative. They are found in the Band 2 fraction. synonym: "juvenile neutrophil" EXACT [] xref: FMA:84197 is_a: CL:0000776 ! immature neutrophil [Term] id: CL:0000583 name: alveolar macrophage namespace: cell def: "A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative." [] comment: Markers: Mouse: F4/80mid, CD11b-/low, CD11c+, CD68+, sialoadhesin+, dectin-1+, MR+, CX3CR1-. synonym: "dust cell" EXACT [] synonym: "MF.Lu" RELATED [] xref: BTO:0000802 xref: CALOHA:TS-0030 xref: FMA:83023 is_a: CL:0000864 ! tissue-resident macrophage is_a: CL:1001603 ! lung macrophage [Term] id: CL:0000588 name: odontoclast namespace: cell def: "A specialized osteoclast associated with the absorption and removal of cementum." [] xref: BTO:0002516 xref: FMA:83027 is_a: CL:0000092 ! osteoclast [Term] id: CL:0000612 name: eosinophilic myelocyte namespace: cell def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte;in this stage, production of primary granules is complete and eosinophil-specific granules has started. No nucleolus is present. These cells are integrin alpha-M-positive, CD13-positive, CD15-positive, CD16-negative, CD24-positive, and CD33-positive." [] xref: BTO:0003454 xref: FMA:83542 is_a: CL:0000772 ! immature eosinophil is_a: CL:0002087 ! nongranular leukocyte [Term] id: CL:0000614 name: basophilic myelocyte namespace: cell def: "A basophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and basophil-specific granules has started. No nucleolus is present. Markers are being integrin alpha-M-positive, fucosyltransferase FUT4-positive, CD33-positive, CD24-positive, aminopeptidase N-positive." [] xref: BTO:0003456 xref: FMA:83543 is_a: CL:0000768 ! immature basophil is_a: CL:0002087 ! nongranular leukocyte [Term] id: CL:0000623 name: natural killer cell namespace: cell def: "A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells." [] synonym: "large granular lymphocyte" BROAD [] synonym: "NK cell" EXACT [] synonym: "null cell" BROAD [] xref: BTO:0000914 xref: BTO:0004716 xref: CALOHA:TS-0664 xref: FMA:63147 xref: FMA:83601 xref: VHOG:0001697 is_a: CL:0001067 ! group 1 innate lymphoid cell [Term] id: CL:0000624 name: CD4-positive, alpha-beta T cell namespace: cell def: "A mature alpha-beta T cell that expresses an alpha-beta T cell receptor and the CD4 coreceptor." [] synonym: "CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta T-cell" EXACT [] synonym: "CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000791 ! mature alpha-beta T cell [Term] id: CL:0000625 name: CD8-positive, alpha-beta T cell namespace: cell def: "A T cell expressing an alpha-beta T cell receptor and the CD8 coreceptor." [] synonym: "CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta T-cell" EXACT [] synonym: "CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000791 ! mature alpha-beta T cell [Term] id: CL:0000647 name: multinucleated giant cell namespace: cell def: "A phagocytic cell formed by the fusion of macrophages, occurs in chronic inflammatory responses to persistent microorganism such as M.tuberculosis, component of granulomas. Sometimes used to refer to megakaryocytes." [] comment: Role or process: Chronic infection, granulomatous inflammation. Consider also megakaryocyte (CL:0000556) as sometimes multinucleated giant cell is used to refer to this. synonym: "foreign body giant cell" EXACT [] synonym: "Langerhans giant cell" EXACT [] synonym: "macrophage polykaryon" EXACT [] synonym: "multinucleate giant cell" EXACT [] synonym: "syncytial giant cell" EXACT [] xref: BTO:0003107 xref: FMA:83035 is_a: CL:0000766 ! myeloid leukocyte [Term] id: CL:0000738 name: leukocyte namespace: cell def: "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [] synonym: "immune cell" EXACT [] synonym: "leucocyte" EXACT [] synonym: "white blood cell" EXACT [] xref: BTO:0000751 xref: CALOHA:TS-0549 xref: FMA:62852 relationship: part_of UBERON:0002405 ! immune system [Term] id: CL:0000766 name: myeloid leukocyte namespace: cell def: "A cell of the monocyte, granulocyte, or mast cell lineage." [] is_a: CL:0000738 ! leukocyte [Term] id: CL:0000767 name: basophil namespace: cell def: "Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive." [] comment: Matures in the bone marrow and account for <1% of leukocytes in the peripheral blood, spleen, and bone marrow. Basophils are described as being CD11a-positive, CD11b-positive, CD13-positive, CD15-positive, CD18-positive, CD21-positive, CD25-positive, CD29-positive, CD35-positive, CD40-positive, CD40L-positive, CD44-positive, CD45R-negative, CD46-positive, CD49a-positive, CD49b-positive, CD49d-positive, CD55-positive, CD59-positive, CD62L-positive, CD63-positive, CD69-positive, CD90-negative, CD116-positive, CD117-negative, CD124-positive, CD125-positive, CD131-positive, CD161-positive, CD184-positive, CD191-positive, CD192-positive, CD197-positive, CD200R3-positive, CD218-positive, CD282-positive, CD284-positive, CD289-positive, CD290-positive, CD294-positive, natural killer cell receptor 2B4-positive, smad1-positive, CD3-negative, CD4-negative, CD7-negative, CD8-negative, CD14-negative, CD15-negative, CD16-negative, CD19-negative, CD20-negative, CD34-negative, CD36-negative, CD45R-negative, CD56-negative, CD57-negative, CD235a-negative, and GR1-negative. Transcription factors- GATA1-positive, PU.1-positive. synonym: "basophilic leucocyte" EXACT [] synonym: "basophilic leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] xref: BTO:0000129 xref: CALOHA:TS-0073 xref: FMA:62862 is_a: CL:0000094 ! granulocyte [Term] id: CL:0000768 name: immature basophil namespace: cell def: "Any of the immature forms of a basophil, in which basophilic specific granules are present but other phenotypic features of the mature form may be lacking." [] synonym: "immature basophilic leucocyte" EXACT [] synonym: "immature basophilic leukocyte" EXACT [] is_a: CL:0000767 ! basophil [Term] id: CL:0000769 name: basophilic metamyelocyte namespace: cell def: "A basophil precursor in the granulocytic series, being a cell intermediate in development between a basophilic myelocyte and a band form basophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are CD11b-positive, CD15-positive, CD16-positive, CD24-positive, CD33-positive, and CD13-positive." [] xref: FMA:84198 is_a: CL:0000768 ! immature basophil [Term] id: CL:0000770 name: band form basophil namespace: cell def: "A late basophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature basophil." [] is_a: CL:0000768 ! immature basophil [Term] id: CL:0000771 name: eosinophil namespace: cell def: "Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive." [] comment: Eosinophils are also CD14-negative, CD32-positive, CD44-positive, CD48-positive, CD69-positive, CD192-negative, MBP1-positive, MBP2-positive, TLR2-negative, TLR4-negative, and lineage-negative (B220, CD2, CD14, CD19, CD56, CD71, CD117, CD123, CD235a (glycophorin A), and TER119). The cytokines IL-3, IL-5, and GM-CSF are involved in their development and differentiation. Usually considered CD16-negative, CD16 is observed on eosinophilic metamyelocyte. synonym: "eosinocyte" EXACT [] synonym: "eosinophilic granulocyte" EXACT [] synonym: "eosinophilic leucocyte" EXACT [] synonym: "eosinophilic leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] xref: BTO:0000399 xref: CALOHA:TS-0279 xref: FMA:62861 is_a: CL:0000094 ! granulocyte [Term] id: CL:0000772 name: immature eosinophil namespace: cell def: "Any of the immature forms of an eosinophil, in which eosinophilic specific granules are present but other phenotypic features of the mature form may be lacking." [] synonym: "immature eosinocyte" EXACT [] synonym: "immature eosinophilic leucocyte" EXACT [] synonym: "immature eosinophilic leukocyte" EXACT [] is_a: CL:0000771 ! eosinophil [Term] id: CL:0000773 name: eosinophilic metamyelocyte namespace: cell def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a eosinophilic myelocyte and a band form eosinophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are integrin alpha-M-positive, fucosyltransferase FUT4-positive, low affinity immunoglobulin gamma Fc region receptor III-positive, CD33-positive, CD24-positive and aminopeptidase N-negative." [] is_a: CL:0000772 ! immature eosinophil [Term] id: CL:0000774 name: band form eosinophil namespace: cell def: "A late eosinophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature eosinophil." [] is_a: CL:0000772 ! immature eosinophil [Term] id: CL:0000775 name: neutrophil namespace: cell def: "Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." [] synonym: "neutrocyte" EXACT [] synonym: "neutrophil leucocyte" EXACT [] synonym: "neutrophil leukocyte" EXACT [] synonym: "neutrophilic leucocyte" EXACT [] synonym: "neutrophilic leukocyte" EXACT [] synonym: "PMN" BROAD [] synonym: "poly" BROAD [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] synonym: "polymorphonuclear neutrophil" BROAD [] synonym: "polynuclear neutrophilic leucocyte" BROAD [] synonym: "polynuclear neutrophilic leukocyte" BROAD [] xref: BTO:0000130 xref: CALOHA:TS-0688 xref: FMA:62860 is_a: CL:0000094 ! granulocyte [Term] id: CL:0000776 name: immature neutrophil namespace: cell def: "Any of the immature forms of a neutrophil in which neutrophilic specific granules are present but other phenotypic features of the mature form may be lacking." [] synonym: "immatuer neutrophilic leukocyte" EXACT [] synonym: "immature neutrocyte" EXACT [] synonym: "immature neutrophil leucocyte" EXACT [] synonym: "immature neutrophil leukocyte" EXACT [] synonym: "immature neutrophilic leucocyte" EXACT [] is_a: CL:0000775 ! neutrophil [Term] id: CL:0000777 name: mesangial phagocyte namespace: cell def: "A tissue-resident macrophage of the renal glomerular mesangium involved in the disposal and degradation of filtration residues, presentation of antigen to T cells and in tissue remodeling." [] synonym: "mesangial cell" BROAD [] is_a: CL:0000864 ! tissue-resident macrophage [Term] id: CL:0000778 name: mononuclear osteoclast namespace: cell def: "A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts." [] comment: Morphology: mononuclear, highly vesicular. is_a: CL:0000092 ! osteoclast is_a: CL:0000842 ! mononuclear cell [Term] id: CL:0000779 name: multinuclear osteoclast namespace: cell def: "A specialized multinuclear osteoclast associated with the absorption and removal of bone." [] comment: Morphology: multinucleated, highly vesicular. synonym: "multinucleated osteoclast" EXACT [] is_a: CL:0000092 ! osteoclast [Term] id: CL:0000780 name: multinuclear odontoclast namespace: cell def: "A specialized multinuclear osteoclast associated with the absorption and removal of cementum." [] comment: Morphology: multinucleated, highly vesicular; location: roots of deciduous (milk) teeth. synonym: "multinucleated odontoclast" EXACT [] is_a: CL:0000588 ! odontoclast is_a: CL:0000779 ! multinuclear osteoclast [Term] id: CL:0000781 name: mononuclear odontoclast namespace: cell def: "A specialized mononuclear osteoclast associated with the absorption and removal of cementum." [] comment: Morphology: Mononuclear, highly vesicular; location: roots of deciduous (milk) teeth. is_a: CL:0000588 ! odontoclast is_a: CL:0000778 ! mononuclear osteoclast [Term] id: CL:0000782 name: myeloid dendritic cell namespace: cell def: "A dendritic cell of the myeloid lineage." [] comment: These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8). synonym: "CD11c+CD123- DC" EXACT [] synonym: "interdigitating cell" BROAD [] synonym: "mDC" EXACT [] synonym: "veiled cell" BROAD [] xref: BTO:0004721 is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 ! conventional dendritic cell [Term] id: CL:0000784 name: plasmacytoid dendritic cell namespace: cell def: "A dendritic cell type of distinct morphology, localization, and surface marker expression (CD123-positive) from other dendritic cell types and associated with early stage immune responses, particularly the release of physiologically abundant amounts of type I interferons in response to infection." [] synonym: "DC2" EXACT [] synonym: "interferon-producing cell" EXACT [] synonym: "IPC" EXACT [] synonym: "lymphoid dendritic cell" EXACT [] synonym: "pDC" EXACT [] synonym: "plasmacytoid monocyte" EXACT [] synonym: "plasmacytoid T cell" EXACT [] synonym: "T-associated plasma cell" EXACT [] synonym: "type 2 DC" EXACT [] xref: BTO:0004625 is_a: CL:0000451 ! dendritic cell [Term] id: CL:0000785 name: mature B cell namespace: cell def: "A B cell that is mature, having left the bone marrow. Initially, these cells are IgM-positive and IgD-positive, and they can be activated by antigen." [] comment: Mature B cells are also reportedly CD10-negative, CD19-positive, CD22-positive, CD34-negative, CD48-positive, CD79a-positive, CD84-positive, CD127-negative, CD352-positive, RAG-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Transcription factors expressed: Pax5-positive. synonym: "mature B lymphocyte" EXACT [] synonym: "mature B-cell" EXACT [] synonym: "mature B-lymphocyte" EXACT [] is_a: CL:0000145 ! professional antigen presenting cell is_a: CL:0001201 ! B cell, CD19-positive [Term] id: CL:0000786 name: plasma cell namespace: cell def: "A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin." [] comment: Plasma cells develop in the spleen and migrate to the bone marrow. Plasma cells are also reportedly CD5-negative, CD10-negative, CD19-positive, CD20-negative, CD21-negative, CD22-negative, CD23-negative, CD24-negative, CD25-negative, CD27-positive, CD34-negative, CD38-positive, CD40-positive, CD43-positive, CD45-positive, CD48-positive, CD53-low, CD80-negative, CD81-positive, CD86-positive, CD95-positive, CD196-negative, CD229-positive, CD270-positive, CD352-positive, CD361-positive, and IgD-negative. Transcription factors: BLIMP1-positive, IRF4-positive, PAX5-negative, SpiB-negative, Ets1-negative, and XBP1-positive. synonym: "effector B cell" RELATED [] synonym: "effector B-cell" RELATED [] synonym: "plasma B cell" EXACT [] synonym: "plasma B-cell" EXACT [] synonym: "plasmacyte" EXACT [] synonym: "plasmocyte" EXACT [] xref: BTO:0000392 xref: FMA:70574 is_a: CL:0000946 ! antibody secreting cell [Term] id: CL:0000787 name: memory B cell namespace: cell def: "A memory B cell is a mature B cell that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin. This cell type has the phenotype CD19-positive, CD20-positive, MHC Class II-positive, and CD138-negative." [] comment: Memory B-cells are also reportedly CD5-negative, CD10-negative, CD21-positive, CD22-positive, CD23-negative, CD24-positive, CD25-positive, CD27-positive, CD34-negative, CD38-negative, CD40-positive, CD43-negative, CD44-positive, CD45-positive, CD53-positive, CD80-negative, CD81-negative, CD86-positive, and CD196/CCR6-positive. synonym: "memory B lymphocyte" EXACT [] synonym: "memory B-cell" EXACT [] synonym: "memory B-lymphocyte" EXACT [] is_a: CL:0000785 ! mature B cell [Term] id: CL:0000788 name: naive B cell namespace: cell def: "A naive B cell is a mature B cell that has the phenotype surface IgD-positive, surface IgM-positive, CD20-positive, CD27-negative and that has not yet been activated by antigen in the periphery." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'naive B cell'. Per DSD: Naive B cells are also reportedly CD10-negative, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD25-negative, CD27-negative, CD34-negative, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD80-negative, CD81-positive, CD84-positive, CD86-negative, CD95-negative, CD138-negative, CD150-positive, CD184/CXCR4-positive, CD185/CXCR5-positive, CD196/CCR6-positive, CD200-positive, CD229-positive, CD243-positive, CD289-positive, CD290-positive, CD352-positive, MHCII/HLA-DR-positive, cadherin 9-positive, and sIgH-positive, Transcription factors: Pax5-positive, ETS1-positive, FOXO1A-positive, KLF4-positive, KLF9-positive, MiTF-positive, OBF1-positive, PLZF-positive, and SpiB-positive. synonym: "naive B lymphocyte" EXACT [] synonym: "naive B-cell" EXACT [] synonym: "naive B-lymphocyte" EXACT [] is_a: CL:0000785 ! mature B cell [Term] id: CL:0000789 name: alpha-beta T cell namespace: cell def: "A T cell that expresses an alpha-beta T cell receptor complex." [] synonym: "alpha-beta T lymphocyte" EXACT [] synonym: "alpha-beta T-cell" EXACT [] synonym: "alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000084 ! T cell [Term] id: CL:0000790 name: immature alpha-beta T cell namespace: cell def: "An alpha-beta T cell that has an immature phenotype and has not completed T cell selection." [] synonym: "immature alpha-beta T lymphocyte" EXACT [] synonym: "immature alpha-beta T-cell" EXACT [] synonym: "immature alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000789 ! alpha-beta T cell is_a: CL:0002420 ! immature T cell [Term] id: CL:0000791 name: mature alpha-beta T cell namespace: cell def: "A alpha-beta T cell that has a mature phenotype." [] synonym: "mature alpha-beta T lymphocyte" EXACT [] synonym: "mature alpha-beta T-cell" EXACT [] synonym: "mature alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000789 ! alpha-beta T cell is_a: CL:0002419 ! mature T cell [Term] id: CL:0000792 name: CD4-positive, CD25-positive, alpha-beta regulatory T cell namespace: cell def: "A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'Treg'. The inclusion of CD127lo in the logical definition is compatible with both human and mouse T cells of this subtype. synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte" EXACT [] synonym: "suppressor T cell" BROAD [] synonym: "suppressor T lymphocyte" BROAD [] synonym: "suppressor T-cell" BROAD [] synonym: "suppressor T-lymphocyte" BROAD [] synonym: "Treg" BROAD [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell is_a: CL:0000815 ! regulatory T cell [Term] id: CL:0000793 name: CD4-positive, alpha-beta intraepithelial T cell namespace: cell def: "A CD4-positive, alpha-beta T cell that is found in the columnar epithelium of the gastrointestinal tract." [] synonym: "CD4-positive, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD4-positive, alpha-beta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell is_a: CL:0000797 ! alpha-beta intraepithelial T cell [Term] id: CL:0000794 name: CD8-positive, alpha-beta cytotoxic T cell namespace: cell def: "A CD8-positive, alpha-beta T cell that is capable of killing target cells in an antigen specific manner with the phenotype perforin-positive and granzyme B-positive." [] comment: Note that while T cells of this subset are loosely referred to 'cytotoxic T cells,' as many other T cell types, including CD4-positive, alpha-beta T cells and gamma-delta T cells exhibit cytotoxicity in vitro and in vivo. synonym: "CD8-positive, alpha-beta cytotoxic T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta cytotoxic T-cell" EXACT [] synonym: "CD8-positive, alpha-beta cytotoxic T-lymphocyte" EXACT [] synonym: "cytotoxic T cell" BROAD [] synonym: "cytotoxic T lymphocyte" BROAD [] synonym: "cytotoxic T-cell" BROAD [] synonym: "cytotoxic T-lymphocyte" BROAD [] synonym: "killer T cell" BROAD [] synonym: "killer T lymphocyte" BROAD [] synonym: "killer T-cell" BROAD [] synonym: "killer T-lymphocyte" BROAD [] xref: CALOHA:TS-0190 xref: FMA:70573 is_a: CL:0000625 ! CD8-positive, alpha-beta T cell [Term] id: CL:0000795 name: CD8-positive, alpha-beta regulatory T cell namespace: cell def: "A CD8-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [] synonym: "CD8+ regulatory T cell" EXACT [] synonym: "CD8+ T(reg)" EXACT [] synonym: "CD8+ Treg" EXACT [] synonym: "CD8-positive T(reg)" EXACT [] synonym: "CD8-positive Treg" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T-lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta Treg" EXACT [] synonym: "suppressor T cell" BROAD [] synonym: "suppressor T lymphocyte" BROAD [] synonym: "suppressor T-cell" BROAD [] synonym: "suppressor T-lymphocyte" BROAD [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell is_a: CL:0000815 ! regulatory T cell [Term] id: CL:0000796 name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell namespace: cell def: "A alpha-beta intraepithelial T cell found in the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." [] synonym: "CD8-positive, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD8-positive, alpha-beta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000797 ! alpha-beta intraepithelial T cell [Term] id: CL:0000797 name: alpha-beta intraepithelial T cell namespace: cell def: "A mature alpha-beta T cell of the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." [] synonym: "alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "alpha-beta intraepithelial T-cell" EXACT [] synonym: "alpha-beta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000791 ! mature alpha-beta T cell is_a: CL:0002496 ! intraepithelial lymphocyte [Term] id: CL:0000798 name: gamma-delta T cell namespace: cell def: "A T cell that expresses a gamma-delta T cell receptor complex." [] comment: Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways. synonym: "gamma-delta T lymphocyte" EXACT [] synonym: "gamma-delta T-cell" EXACT [] synonym: "gamma-delta T-lymphocyte" EXACT [] synonym: "gammadelta T cell" EXACT [] synonym: "gd T cell" RELATED [] is_a: CL:0000084 ! T cell [Term] id: CL:0000799 name: immature gamma-delta T cell namespace: cell def: "A gamma-delta T cell that has an immature phenotype." [] comment: Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways. synonym: "immature gamma-delta T lymphocyte" EXACT [] synonym: "immature gamma-delta T-cell" EXACT [] synonym: "immature gamma-delta T-lymphocyte" EXACT [] is_a: CL:0000798 ! gamma-delta T cell is_a: CL:0002420 ! immature T cell [Term] id: CL:0000800 name: mature gamma-delta T cell namespace: cell def: "A gamma-delta T cell that has a mature phenotype. These cells can be found in tissues and circulation where they express unique TCR repertoire depending on their location." [] synonym: "mature gamma-delta T lymphocyte" EXACT [] synonym: "mature gamma-delta T-cell" EXACT [] synonym: "mature gamma-delta T-lymphocyte" EXACT [] is_a: CL:0000798 ! gamma-delta T cell is_a: CL:0002419 ! mature T cell [Term] id: CL:0000801 name: gamma-delta intraepithelial T cell namespace: cell def: "A mature gamma-delta T cell that is found in the columnar epithelium of the gastrointestinal tract. These cells participate in mucosal immune responses." [] synonym: "gamma-delta intraepithelial T lymphocyte" EXACT [] synonym: "gamma-delta intraepithelial T-cell" EXACT [] synonym: "gamma-delta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000800 ! mature gamma-delta T cell is_a: CL:0002496 ! intraepithelial lymphocyte [Term] id: CL:0000802 name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell namespace: cell def: "A gamma-delta intraepithelial T cell that has the phenotype CD8-alpha alpha-positive." [] synonym: "CD8-positive, gamma-delta intraepithelial T lymphocyte" EXACT [] synonym: "CD8-positive, gamma-delta intraepithelial T-cell" EXACT [] synonym: "CD8-positive, gamma-delta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000801 ! gamma-delta intraepithelial T cell [Term] id: CL:0000803 name: CD4-negative CD8-negative gamma-delta intraepithelial T cell namespace: cell def: "A gamma-delta intraepithelial T cell that has the phenotype CD4-negative and CD8-negative." [] synonym: "CD4-positive, gamma-delta intraepithelial T lymphocyte" EXACT [] synonym: "CD4-positive, gamma-delta intraepithelial T-cell" EXACT [] synonym: "CD4-positive, gamma-delta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000801 ! gamma-delta intraepithelial T cell [Term] id: CL:0000805 name: immature single positive thymocyte namespace: cell def: "A thymocyte that has the phenotype CD4-negative, CD8-positive, CD44-negative, CD25-negative, and pre-TCR-positive." [] comment: Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and rearranging the T cell receptor alpha chain and expressing the CD8 coreceptor. This stage comes between the DN4 and DP stages. synonym: "immature single positive T cell" EXACT [] synonym: "immature single positive T lymphocyte" EXACT [] synonym: "immature single positive T-lymphocyte" EXACT [] synonym: "ISP" EXACT [] synonym: "T.ISP.th" EXACT [] is_a: CL:0000893 ! thymocyte [Term] id: CL:0000806 name: DN2 thymocyte namespace: cell def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive." [] comment: Note that this type of thymocyte is at the earliest stage of T cell receptor rearrangement of the beta, gamma, and delta T cell receptor chains. synonym: "DN2 alpha-beta immature T lymphocyte" EXACT [] synonym: "DN2 alpha-beta immature T-cell" EXACT [] synonym: "DN2 alpha-beta immature T-lymphocyte" EXACT [] synonym: "DN2 cell" EXACT [] synonym: "DN2 immature T cell" EXACT [] synonym: "double negative 2" EXACT [] synonym: "preT.DN2.Th" EXACT [] synonym: "TN2 cell" EXACT [] synonym: "TN2 thymocyte" EXACT [] is_a: CL:0002489 ! double negative thymocyte [Term] id: CL:0000807 name: DN3 thymocyte namespace: cell def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, and CD25-positive and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [] synonym: "DN3 alpha-beta immature T lymphocyte" EXACT [] synonym: "DN3 alpha-beta immature T-cell" EXACT [] synonym: "DN3 alpha-beta immature T-lymphocyte" EXACT [] synonym: "DN3 cell" EXACT [] synonym: "DN3 immature T cell" EXACT [] synonym: "double negative 3" EXACT [] synonym: "early cortical thymocyte" BROAD [] synonym: "preT.DN3.Th" EXACT [] synonym: "TN3 cell" EXACT [] synonym: "TN3 thymocyte" EXACT [] is_a: CL:0002489 ! double negative thymocyte [Term] id: CL:0000808 name: DN4 thymocyte namespace: cell def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." [] comment: Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and beginning to rearrange the T cell receptor alpha chain. synonym: "DN4 alpha-beta immature T lymphocyte" EXACT [] synonym: "DN4 alpha-beta immature T-lymphocyte" EXACT [] synonym: "DN4 cell" EXACT [] synonym: "DN4 immature T cell" EXACT [] synonym: "DN4 immature T-cell" EXACT [] synonym: "double negative 4" EXACT [] synonym: "early cortical thymocyte" BROAD [] synonym: "T.DN4.th" EXACT [] is_a: CL:0002489 ! double negative thymocyte [Term] id: CL:0000809 name: double-positive, alpha-beta thymocyte namespace: cell def: "A thymocyte expressing the alpha-beta T cell receptor complex as well as both the CD4 and CD8 coreceptors." [] comment: Thymocytes of this stage are undergoing positive and negative selection. synonym: "double-positive, alpha-beta immature T lymphocyte" EXACT [] synonym: "DP cell" EXACT [] synonym: "DP thymocyte" EXACT [] synonym: "late cortical thymocyte" BROAD [] is_a: CL:0000790 ! immature alpha-beta T cell is_a: CL:0000893 ! thymocyte [Term] id: CL:0000810 name: CD4-positive, alpha-beta thymocyte namespace: cell def: "An immature alpha-beta T cell that is located in the thymus and is CD4-positive and CD8-negative." [] synonym: "CD4-positive, alpha-beta immature T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta immature T-cell" EXACT [] synonym: "CD4-positive, alpha-beta immature T-lymphocyte" EXACT [] synonym: "SP CD4 cell" EXACT [] is_a: CL:0000790 ! immature alpha-beta T cell is_a: CL:0000893 ! thymocyte [Term] id: CL:0000811 name: CD8-positive, alpha-beta thymocyte namespace: cell def: "An immature alpha-beta T cell that is located in the thymus and is CD8-positive and CD4-negative." [] synonym: "CD8-positive, alpha-beta immature T cell" RELATED [] synonym: "CD8-positive, alpha-beta immature T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta immature T-cell" EXACT [] synonym: "CD8-positive, alpha-beta immature T-lymphocyte" EXACT [] synonym: "SP CD8 cell" EXACT [] is_a: CL:0000790 ! immature alpha-beta T cell is_a: CL:0000893 ! thymocyte [Term] id: CL:0000813 name: memory T cell namespace: cell def: "A long-lived, antigen-experienced T cell that has acquired a memory phenotype including distinct surface markers and the ability to differentiate into an effector T cell upon antigen reexposure." [] synonym: "memory T lymphocyte" EXACT [] synonym: "memory T-cell" EXACT [] synonym: "memory T-lymphocyte" EXACT [] xref: BTO:0003435 is_a: CL:0002419 ! mature T cell [Term] id: CL:0000814 name: mature NK T cell namespace: cell def: "A mature alpha-beta T cell of a distinct lineage that bears natural killer markers and a T cell receptor specific for a limited set of ligands. NK T cells have activation and regulatory roles particularly early in an immune response." [] synonym: "mature natural killer T cell" EXACT [] synonym: "mature natural killer T lymphocyte" EXACT [] synonym: "mature natural killer T-cell" EXACT [] synonym: "mature natural killer T-lymphocyte" EXACT [] synonym: "mature NK T lymphocyte" EXACT [] synonym: "mature NK T-cell" EXACT [] synonym: "mature NK T-lymphocyte" EXACT [] synonym: "mature NKT cell" EXACT [] is_a: CL:0000791 ! mature alpha-beta T cell [Term] id: CL:0000815 name: regulatory T cell namespace: cell def: "A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [] comment: This cell type may express FoxP3 and CD25 and secretes IL-10 and TGF-beta. synonym: "regulatory T lymphocyte" EXACT [] synonym: "regulatory T-cell" EXACT [] synonym: "regulatory T-lymphocyte" EXACT [] synonym: "suppressor T cell" BROAD [] synonym: "suppressor T lymphocyte" BROAD [] synonym: "suppressor T-cell" BROAD [] synonym: "suppressor T-lymphocyte" BROAD [] synonym: "Treg" EXACT [] xref: BTO:0004520 xref: FMA:84070 is_a: CL:0002419 ! mature T cell [Term] id: CL:0000816 name: immature B cell namespace: cell def: "An immature B cell is a B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation." [] comment: Immature B cells are also reportedly CD5-positive, CD10-positive, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD24-positive, CD25-negative, CD27-negative, CD34-negative, CD38-positive, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD79a-positive, CD80-negative, CD81-positive, CD86-negative, CD95-negative, CD127-negative, CD138-negative, CD185-positive, CD196-positive, MHCII/HLA-DR-positive, RAG-positive, TdT-negative, Vpre-B-negative, and preBCR-negative. Transcription factors expressed: Pax5-positive. synonym: "immature B lymphocyte" EXACT [] synonym: "immature B-cell" EXACT [] synonym: "immature B-lymphocyte" EXACT [] synonym: "newly formed B cell" EXACT [] is_a: CL:0001201 ! B cell, CD19-positive [Term] id: CL:0000817 name: precursor B cell namespace: cell def: "A precursor B cell is a B cell with the phenotype CD10-positive." [] synonym: "pre-B cell" RELATED [] xref: BTO:0001133 xref: CALOHA:TS-0819 is_a: CL:0001201 ! B cell, CD19-positive [Term] id: CL:0000818 name: transitional stage B cell namespace: cell def: "An immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage with the phenotype surface IgM-positive and CD19-positive, and are subject to the process of B cell selection. A transitional B cell migrates from the bone marrow into the peripheral circulation, and then to the spleen." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'transitional B cell'. synonym: "T1 B cell" NARROW [] synonym: "T2 B cell" NARROW [] synonym: "T3 B cell" NARROW [] synonym: "transitional B cell" EXACT [] synonym: "transitional stage B lymphocyte" EXACT [] synonym: "transitional stage B-cell" EXACT [] synonym: "transitional stage B-lymphocyte" EXACT [] is_a: CL:0001201 ! B cell, CD19-positive [Term] id: CL:0000819 name: B-1 B cell namespace: cell def: "A B cell of distinct lineage and surface marker expression. B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas. These cells are CD43-positive." [] comment: There are small numbers of B-1 cells found in the lymph nodes and spleen, while larger numbers can be found in the peritoneal and pleural cavities. B-1 B cells are reportedly CD11b-positive, CD20-positive, CD21-positive, CD27-positive, CD44-positive, CD45RB-positive, CD48-positive, CD70-negative, CD150-positive, CD244-negative, CD352-positive, sIgM-positive, and sIgD-low. synonym: "B-1 B lymphocyte" EXACT [] synonym: "B-1 B-cell" EXACT [] synonym: "B-1 B-lymphocyte" EXACT [] synonym: "B-1 cell" EXACT [] synonym: "B1 B cell" EXACT [] synonym: "B1 B lymphocyte" EXACT [] synonym: "B1 B-cell" EXACT [] synonym: "B1 B-lymphocyte" EXACT [] synonym: "B1 cell" EXACT [] is_a: CL:0000785 ! mature B cell [Term] id: CL:0000820 name: B-1a B cell namespace: cell def: "A B-1 B cell that has the phenotype CD5-positive." [] synonym: "B-1a B lymphocyte" EXACT [] synonym: "B-1a B-cell" EXACT [] synonym: "B-1a B-lymphocyte" EXACT [] synonym: "B1a B cell" EXACT [] synonym: "B1a B lymphocyte" EXACT [] synonym: "B1a B-cell" EXACT [] synonym: "B1a B-lymphocyte" EXACT [] synonym: "B1a cell" EXACT [] synonym: "CD5(+) B1 cell" EXACT [] synonym: "CD5+ B1 cell" EXACT [] synonym: "CD5-positive B1 cell" EXACT [] is_a: CL:0000819 ! B-1 B cell [Term] id: CL:0000821 name: B-1b B cell namespace: cell def: "A B-1 B cell that has the phenotype CD5-negative, but having other phenotypic attributes of a B-1 B cell." [] synonym: "B-1b B lymphocyte" EXACT [] synonym: "B-1b B-cell" EXACT [] synonym: "B-1b B-lymphocyte" EXACT [] synonym: "B1b B cell" EXACT [] synonym: "B1b B lymphocyte" EXACT [] synonym: "B1b B-cell" EXACT [] synonym: "B1b B-lymphocyte" EXACT [] synonym: "B1b cell" EXACT [] is_a: CL:0000819 ! B-1 B cell [Term] id: CL:0000822 name: B-2 B cell namespace: cell def: "A conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells. These cells are CD43-negative." [] comment: B-2 B cells are reportedly CD48-positive, CD244-negative, and CD352-positive. synonym: "B-0 B cell" RELATED [] synonym: "B-2 B lymphocyte" EXACT [] synonym: "B-2 B-cell" EXACT [] synonym: "B-2 B-lymphocyte" EXACT [] synonym: "B2 B cell" EXACT [] synonym: "B2 B lymphocyte" EXACT [] synonym: "B2 B-cell" EXACT [] synonym: "B2 B-lymphocyte" EXACT [] synonym: "B2 cell" EXACT [] is_a: CL:0000785 ! mature B cell [Term] id: CL:0000823 name: immature natural killer cell namespace: cell def: "A natural killer cell that is developmentally immature and expresses natural killer cell receptors (NKR)." [] comment: In mouse the NKR are Ly49 molecules and in human these cells express KIR molecules. synonym: "immature NK cell" EXACT [] synonym: "p-NK" RELATED [] is_a: CL:0000623 ! natural killer cell is_a: CL:0001082 ! immature innate lymphoid cell [Term] id: CL:0000824 name: mature natural killer cell namespace: cell def: "A natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class I and other stress related molecules." [] synonym: "LAK cell" BROAD [] synonym: "lymphokine activated killer cell" BROAD [] synonym: "mature NK cell" EXACT [] is_a: CL:0000623 ! natural killer cell [Term] id: CL:0000840 name: immature conventional dendritic cell namespace: cell def: "An immature cell of the conventional dendritic cell lineage, characterized by high levels of antigen uptake via endocytosis, macropinocytosis, and phagocytosis, and typically found resident in the tissues. Markers for this cell are CD80-low, CD86-low, and MHC-II-low." [] synonym: "immature myeloid dendritic cell" NARROW [] is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 ! conventional dendritic cell [Term] id: CL:0000841 name: mature conventional dendritic cell namespace: cell def: "A mature cell of the conventional dendritic cell lineage, characterized by a high capacity for antigen presentation and typically found in a lymph node." [] synonym: "mature dendritic cell" BROAD [] synonym: "mature myeloid dendritic cell" NARROW [] xref: FMA:83038 is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 ! conventional dendritic cell [Term] id: CL:0000842 name: mononuclear cell namespace: cell def: "A leukocyte with a single non-segmented nucleus in the mature form." [] synonym: "mononuclear leukocyte" EXACT [] synonym: "peripheral blood mononuclear cell" NARROW [] xref: BTO:0000878 xref: CALOHA:TS-0768 xref: FMA:86713 is_a: CL:0000738 ! leukocyte [Term] id: CL:0000843 name: follicular B cell namespace: cell def: "A resting mature B cell that has the phenotype IgM-positive, IgD-positive, CD23-positive and CD21-positive, and found in the B cell follicles of the white pulp of the spleen or the corticol areas of the peripheral lymph nodes. This cell type is also described as being CD19-positive, B220-positive, AA4-negative, CD43-negative, and CD5-negative." [] comment: Follicular B cells are also reportedly CD48-positive, CD84-positive, CD229-positive, and CD352-positive. synonym: "Fo B cell" EXACT [] synonym: "Fo B-cell" EXACT [] synonym: "follicular B lymphocyte" EXACT [] synonym: "follicular B-cell" EXACT [] synonym: "follicular B-lymphocyte" EXACT [] is_a: CL:0000822 ! B-2 B cell [Term] id: CL:0000844 name: germinal center B cell namespace: cell def: "A rapidly cycling mature B cell that has distinct phenotypic characteristics and is involved in T-dependent immune responses and located typically in the germinal centers of lymph nodes. This cell type expresses Ly77 after activation." [] comment: Germinal center B cells are also reportedly CD10-positive, CD19-positive, CD20-positive, CD38-positive, CD44-low, CD45-positive, CD48-positive, CD95-positive, CD352-positive, and HLA-DR-positive. Transcription factors: BCL6-positive, Ets1-positive, IRF8-positive, MTA3-positive, OBF1-positive, PAX5-positive, SpiB-positive, and STAT3-positive. synonym: "GC B cell" EXACT [] synonym: "GC B lymphocyte" EXACT [] synonym: "GC B-cell" EXACT [] synonym: "GC B-lymphocyte" EXACT [] synonym: "germinal center B lymphocyte" EXACT [] synonym: "germinal center B-cell" EXACT [] synonym: "germinal center B-lymphocyte" EXACT [] is_a: CL:0000785 ! mature B cell relationship: part_of UBERON:0001745 ! secondary nodular lymphoid tissue [Term] id: CL:0000845 name: marginal zone B cell namespace: cell def: "A mature B cell that is located in the marginal zone of the spleen with the phenotype CD23-negative and CD21-positive and expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL. This cell type is also described as being CD19-positive, B220-positive, IgM-high, AA4-negative, CD35-high." [] comment: MZ B cells are reportedly CD1-positive (mice), CD20-positive, CD48-positive, CD84-positive, CD150-positive, CD229-positive, and CD352-positive. synonym: "marginal zone B lymphocyte" EXACT [] synonym: "marginal zone B-cell" EXACT [] synonym: "marginal zone B-lymphocyte" EXACT [] synonym: "MZ B cell" EXACT [] synonym: "MZ B lymphocyte" EXACT [] synonym: "MZ B-cell" EXACT [] synonym: "MZ B-lymphocyte" EXACT [] is_a: CL:0000785 ! mature B cell is_a: CL:2000074 ! splenocyte relationship: part_of UBERON:0001251 ! marginal zone of spleen [Term] id: CL:0000860 name: classical monocyte namespace: cell def: "A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes." [] comment: Markers: CCR2+CXCCR1 (human, mouse, rat). synonym: "inflammatory monocyte" EXACT [] is_a: CL:0000576 ! monocyte [Term] id: CL:0000861 name: elicited macrophage namespace: cell def: "A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive." [] comment: Markers: CD11b+, CD68+; Mouse: F4/80+; role or process: immune, inflammation (inflammatory response). synonym: "free macrophage" EXACT [] synonym: "wandering histiocyte" EXACT [] xref: FMA:84643 xref: FMA:84645 is_a: CL:0000235 ! macrophage [Term] id: CL:0000862 name: suppressor macrophage namespace: cell def: "A macrophage that suppresses immune responses." [] comment: Markers: May express: IL10, TGFbeta. is_a: CL:0000861 ! elicited macrophage [Term] id: CL:0000863 name: inflammatory macrophage namespace: cell def: "An elicited macrophage that is recruited into the tissues in response to injury and infection as part of an inflammatory response, expresses high levels of pro-inflammatory cytokines, ROS and NO, and shows potent microbicidal activity." [] comment: Markers: Express: TNFa, IL1b, IL6, iNOS, NADPH-oxidase; produce: reactive oxygen species, nitric oxide; role or process: immune, inflammation (inflammatory response). synonym: "classically activated macrophage" EXACT [] synonym: "M1 macrophage" RELATED [] is_a: CL:0000861 ! elicited macrophage [Term] id: CL:0000864 name: tissue-resident macrophage namespace: cell def: "A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [] synonym: "fixed macrophage" EXACT [] synonym: "resting histiocyte" EXACT [] xref: FMA:84642 xref: FMA:84644 is_a: CL:0000235 ! macrophage [Term] id: CL:0000865 name: gastrointestinal tract (lamina propria) macrophage namespace: cell def: "A gut-associated lymphoid tissue macrophage found in lamina propria of the gut." [] is_a: CL:0000885 ! gut-associated lymphoid tissue macrophage [Term] id: CL:0000866 name: thymic macrophage namespace: cell def: "A tissue-resident macrophage resident found in the thymus, involved in the clearance of apoptotic thymocytes." [] comment: Role or process: immune, clearance of apoptotic thymocytes, antigen-presentation. is_a: CL:0000864 ! tissue-resident macrophage relationship: part_of UBERON:0002370 ! thymus [Term] id: CL:0000867 name: secondary lymphoid organ macrophage namespace: cell def: "A tissue-resident macrophage found in a secondary lymphoid organ." [] is_a: CL:0000864 ! tissue-resident macrophage [Term] id: CL:0000868 name: lymph node macrophage namespace: cell def: "A secondary lymphoid organ macrophage found in a lymph node. This cell is CD169-high." [] comment: Marker was observed on rat cells. synonym: "MF.LN" EXACT [] is_a: CL:0000867 ! secondary lymphoid organ macrophage relationship: part_of UBERON:0000029 ! lymph node [Term] id: CL:0000869 name: tonsillar macrophage namespace: cell def: "A gut-associated lymphoid tissue macrophage found in tonsils." [] is_a: CL:0000885 ! gut-associated lymphoid tissue macrophage relationship: part_of UBERON:0002372 ! tonsil [Term] id: CL:0000870 name: Peyer's patch macrophage namespace: cell def: "A gut-associated lymphoid tissue macrophage found in the Peyer's patches." [] is_a: CL:0000885 ! gut-associated lymphoid tissue macrophage relationship: part_of UBERON:0001211 ! Peyer's patch [Term] id: CL:0000871 name: splenic macrophage namespace: cell def: "A secondary lymphoid organ macrophage found in the spleen." [] comment: Role or process: immune, clearance of apoptotic and senescent cells. xref: FMA:83026 is_a: CL:0000867 ! secondary lymphoid organ macrophage is_a: CL:2000074 ! splenocyte [Term] id: CL:0000872 name: splenic marginal zone macrophage namespace: cell def: "A splenic macrophage found in the marginal zone of the spleen, involved in recognition and clearance of particulate material from the splenic circulation. Markers include F4/80-negative, MARCO-positive, SR-A-positive, SIGN-R1-positive, and Dectin2-positive." [] comment: Markers: Mouse: F4/80-, MARCO+, SR-A+, SIGN-R1+, Dectin2+. is_a: CL:0000871 ! splenic macrophage relationship: part_of UBERON:0001251 ! marginal zone of spleen [Term] id: CL:0000873 name: splenic metallophillic macrophage namespace: cell def: "A splenic macrophage found in the areas surrounding the white pulp of the spleen, adjacent to the marginal sinus. Markers include F4/80-negative, Dectin2-low, sialoadhesin-positive." [] comment: Markers: Mouse: F4/80-, Dectin2-low, sialoadhesin+. is_a: CL:0000871 ! splenic macrophage relationship: part_of UBERON:0001251 ! marginal zone of spleen [Term] id: CL:0000874 name: splenic red pulp macrophage namespace: cell def: "A splenic macrophage found in the red-pulp of the spleen, and involved in immune responses to blood-borne pathogens and in the clearance of senescent erythrocytes. Markers include F4/80-positive, CD68-positive, MR-positive, Dectin2-positive, macrosialin-positive, and sialoadhesin-low." [] comment: Markers: Mouse: F4/80+, CD68+, MR+, Dectin2+, macrosialin+, sialoadhesin-low; role or process: immune, clearance of senescent erythrocytes. is_a: CL:0000871 ! splenic macrophage relationship: part_of UBERON:0001250 ! red pulp of spleen [Term] id: CL:0000875 name: non-classical monocyte namespace: cell def: "A type of monocyte characterized by low expression of CCR2, low responsiveness to monocyte chemoattractant CCL2/MCP1, low phagocytic activity, and decrease size relative to classical monocytes, but increased co-stimulatory activity. May also play a role in tissue repair." [] comment: Markers: CCR2-CX3CCR1+ (human, mouse, rat); human: CD16+, CCR5+, CD32/FcgRII-high, MHCII+, CD86+; mouse: CD62L-Ly6C-. synonym: "patrolling monocyte" EXACT [] synonym: "resident monocyte" EXACT [] is_a: CL:0000576 ! monocyte [Term] id: CL:0000876 name: splenic white pulp macrophage namespace: cell def: "A splenic macrophage found in the white pulp of the spleen. Markers include F4/80-negative, CD68-positive, and macrosialin-positive." [] comment: Markers: Mouse: F4/80-, CD68+, macrosialin+. is_a: CL:0000871 ! splenic macrophage relationship: part_of UBERON:0001959 ! white pulp of spleen [Term] id: CL:0000877 name: splenic tingible body macrophage namespace: cell def: "A splenic white pulp macrophage found in and around the germinal centers of the white pulp of the spleen that participates in phagocytosis of apoptotic B cells from the germinal centers. A marker for a cell of this type is Mertk-positive." [] is_a: CL:0000876 ! splenic white pulp macrophage relationship: part_of UBERON:0001249 ! spleen lymphoid follicle [Term] id: CL:0000878 name: central nervous system macrophage namespace: cell def: "A tissue-resident macrophage found in the central nervous system." [] synonym: "CNS macrophage" EXACT [] is_a: CL:0000864 ! tissue-resident macrophage [Term] id: CL:0000879 name: meningeal macrophage namespace: cell def: "A central nervous system macrophage found in the meninges (the three membranes that surround the brain). This macrophage types is highly phagocytic and expresses scavenger receptors." [] is_a: CL:0000878 ! central nervous system macrophage [Term] id: CL:0000880 name: choroid-plexus macrophage namespace: cell def: "A central nervous system macrophage found at the interface between the blood and the cerebrospinal fluid in the brain. This cell expresses scavenger receptors." [] is_a: CL:0000878 ! central nervous system macrophage [Term] id: CL:0000881 name: perivascular macrophage namespace: cell def: "A central nervous system macrophage found in small blood vessels in the brain. Markers include CD14+CD16+CD163+." [] comment: Markers: Human/monkey, mice: CD163. Human: CD14+CD16+CD163+. is_a: CL:0000878 ! central nervous system macrophage [Term] id: CL:0000882 name: thymic medullary macrophage namespace: cell def: "A thymic macrophage found in the thymic medulla." [] is_a: CL:0000866 ! thymic macrophage relationship: part_of UBERON:0002124 ! medulla of thymus [Term] id: CL:0000883 name: thymic cortical macrophage namespace: cell def: "A thymic macrophage found in the thymic cortex." [] is_a: CL:0000866 ! thymic macrophage relationship: part_of UBERON:0002123 ! cortex of thymus [Term] id: CL:0000884 name: mucosa-associated lymphoid tissue macrophage namespace: cell def: "A tissue-resident macrophage found in the mucosa associated lymphoid tissue." [] is_a: CL:0000867 ! secondary lymphoid organ macrophage relationship: part_of UBERON:0001961 ! mucosa-associated lymphoid tissue [Term] id: CL:0000885 name: gut-associated lymphoid tissue macrophage namespace: cell def: "A mucosa-associated lymphoid tissue macrophage found in the mucosa-associated lymphoid tissues of the gut." [] is_a: CL:0000884 ! mucosa-associated lymphoid tissue macrophage relationship: part_of UBERON:0001962 ! gut-associated lymphoid tissue [Term] id: CL:0000886 name: nasal and broncial associated lymphoid tissue macrophage namespace: cell def: "A mucosa-associated lymphoid tissue macrophage found in the nasal and bronchial mucosa-associated lymphoid tissues." [] is_a: CL:0000884 ! mucosa-associated lymphoid tissue macrophage relationship: part_of UBERON:0001963 ! bronchial-associated lymphoid tissue [Term] id: CL:0000887 name: lymph node subcapsular sinus macrophage namespace: cell def: "A lymph node macrophage found in the subcapsular sinus of lymph nodes that participates in sensing, clearance, and antigen presentation of lymph-borne particulate antigens. This macrophage is capable of activating invaraint NKT cells and is CD169-positive." [] is_a: CL:0000868 ! lymph node macrophage [Term] id: CL:0000888 name: lymph node tingible body macrophage namespace: cell def: "A lymph node macrophage found in the cortex of lymph nodes, in particular in and around the germinal centers, and that participates in phagocytosis of apoptotic B cells from the germinal centers." [] is_a: CL:0000868 ! lymph node macrophage relationship: part_of UBERON:0002006 ! cortex of lymph node [Term] id: CL:0000889 name: myeloid suppressor cell namespace: cell def: "An immature myeloid leukocyte of heterogeneous phenotype found particularly in cancer and sepsis patients that is capable of suppressing activity of T cells in ex vivo assays. This cell type is CD45-positive, CD11b-positive." [] comment: Markers: Mouse: CD11b+GR1+CD31+; Human: CD34+ CD33+CD15-CD13+. (According to some reports in humans these cells are iNOS+ARG1+IL13+IFNg+); location: In cancerous tissue; in the blood and lymphoid organs in sepsis. is_a: CL:0000766 ! myeloid leukocyte [Term] id: CL:0000890 name: alternatively activated macrophage namespace: cell def: "An elicited macrophage characterized by low production of pro-inflammatory and Th1 polarizing cytokines and high expression of arginase-1, and associated with tissue remodelling." [] comment: Role or process: tissue remodeling. synonym: "M2 macrophage" RELATED [] is_a: CL:0000861 ! elicited macrophage [Term] id: CL:0000893 name: thymocyte namespace: cell def: "An immature T cell located in the thymus." [] synonym: "immature T cell" BROAD [] synonym: "immature T lymphocyte" BROAD [] synonym: "immature T-cell" BROAD [] synonym: "immature T-lymphocyte" BROAD [] synonym: "thymic lymphocyte" EXACT [] xref: BTO:0001372 xref: CALOHA:TS-1042 xref: FMA:72202 xref: XAO:0003159 is_a: CL:0002420 ! immature T cell relationship: part_of UBERON:0002370 ! thymus [Term] id: CL:0000894 name: DN1 thymic pro-T cell namespace: cell def: "A pro-T cell that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative." [] synonym: "DN1 thymic pro-T lymphocyte" EXACT [] synonym: "DN1 thymic pro-T-cell" EXACT [] synonym: "DN1 thymic pro-T-lymphocyte" EXACT [] synonym: "DN1 thymic progenitor T cell" EXACT [] synonym: "DN1 thymocyte" EXACT [] synonym: "double negative 1" EXACT [] synonym: "preT.DN1.Th" EXACT [] relationship: part_of UBERON:0002370 ! thymus [Term] id: CL:0000895 name: naive thymus-derived CD4-positive, alpha-beta T cell namespace: cell def: "An antigen inexperienced CD4-positive, alpha-beta T cell with the phenotype CCR7-positive, CD127-positive and CD62L-positive. This cell type develops in the thymus. This cell type is also described as being CD25-negative, CD62L-high, and CD44-low." [] comment: These cells have not been exposed to antigen following thymic T-cell selection; found in blood and secondary lymphoid organs. This cell type is compatible with the HIPC Lyoplate markers for 'naive CD4+ T cell', but includes additional markers known to be expressed on naive CD4+ T cells. synonym: "naive CD4+ T cell" BROAD [] synonym: "naive thymus-derived CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "naive thymus-derived CD4-positive, alpha-beta T-cell" EXACT [] synonym: "naive thymus-derived CD4-positive, alpha-beta T-lymphocyte" EXACT [] synonym: "T.4Nve.Sp" EXACT [] synonym: "Th0" EXACT [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell is_a: CL:0000898 ! naive T cell [Term] id: CL:0000896 name: activated CD4-positive, alpha-beta T cell namespace: cell def: "A recently activated CD4-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive." [] synonym: "activated CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "activated CD4-positive, alpha-beta T-cell" EXACT [] synonym: "activated CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell [Term] id: CL:0000897 name: CD4-positive, alpha-beta memory T cell namespace: cell def: "A CD4-positive, alpha-beta T cell that has differentiated into a memory T cell." [] synonym: "CD4-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta memory T-cell" EXACT [] synonym: "CD4-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "T4.Mem.Sp" RELATED [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell is_a: CL:0000813 ! memory T cell property_value: http://purl.org/dc/elements/1.1/creator https://orcid.org/0000-0001-9990-8331 xsd:string [Term] id: CL:0000898 name: naive T cell namespace: cell def: "Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." [] synonym: "naive T lymphocyte" EXACT [] synonym: "naive T-cell" EXACT [] synonym: "naive T-lymphocyte" EXACT [] is_a: CL:0002419 ! mature T cell [Term] id: CL:0000899 name: T-helper 17 cell namespace: cell def: "CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive, CXCR3-negative, CCR6-positive, and capable of producing IL-17." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'Th17 CD4+ T cell', but its logical definition includes additional known characteristics of T-helper 17 T cells. synonym: "helper T cell type 17" EXACT [] synonym: "IL-17-producing CD4+ T helper" EXACT [] synonym: "T helper cells type 17" EXACT [] synonym: "T(H)-17 cell" EXACT [] synonym: "Th17 CD4+ T cell" EXACT [] synonym: "Th17 cell" EXACT [] synonym: "Th17 T cell" EXACT [] synonym: "Th17 T lymphocyte" EXACT [] synonym: "Th17 T-cell" EXACT [] synonym: "Th17 T-lymphocyte" EXACT [] is_a: CL:0000492 ! CD4-positive helper T cell [Term] id: CL:0000900 name: naive thymus-derived CD8-positive, alpha-beta T cell namespace: cell def: "A CD8-positive, alpha-beta T cell that has not experienced activation via antigen contact and has the phenotype CD45RA-positive, CCR7-positive and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." [] comment: This cell traffics in secondary lymphoid organs and blood. This cell type is compatible with the HIPC Lyoplate markers for 'naive CD8+ T cell', but includes additional markers known to be expressed on naive CD8+ T cells. synonym: "naive CD8+ T cell" BROAD [] synonym: "naive thymus-dervied CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "naive thymus-dervied CD8-positive, alpha-beta T-cell" EXACT [] synonym: "naive thymus-dervied CD8-positive, alpha-beta T-lymphocyte" EXACT [] synonym: "T.8Nve.Sp" NARROW [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell is_a: CL:0000898 ! naive T cell [Term] id: CL:0000901 name: Tr1 cell namespace: cell def: "CD4-positive alpha-beta T cell with regulatory function that produces IL-10." [] comment: These cells are reportedly induced by IL-10 and are capable of producing IFN-gamma, IL-5, IL-10, and TGF-beta.) synonym: "T-regulatory T cell type 1" EXACT [] synonym: "Tr1 T cell" EXACT [] synonym: "Tr1 T lymphocyte" EXACT [] synonym: "Tr1 T-cell" EXACT [] synonym: "Tr1 T-lymphocyte" EXACT [] is_a: CL:0000492 ! CD4-positive helper T cell is_a: CL:0000815 ! regulatory T cell [Term] id: CL:0000902 name: induced T-regulatory cell namespace: cell def: "CD4-positive alpha-beta T cell with the phenotype CD25-positive, CTLA-4-positive, and FoxP3-positive with regulatory function." [] synonym: "adaptive Treg" RELATED [] synonym: "aTreg" RELATED [] synonym: "induced regulatory T cell" EXACT [] synonym: "induced regulatory T lymphocyte" EXACT [] synonym: "induced regulatory T-cell" EXACT [] synonym: "induced regulatory T-lymphocyte" EXACT [] synonym: "induced Treg" EXACT [] synonym: "iTreg" EXACT [] is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell [Term] id: CL:0000903 name: natural T-regulatory cell namespace: cell def: "CD4-positive alpha-beta T cell with the phenotype FoxP3-positive, CD25-positive, CD62L-positive, and CTLA-4 positive with regulatory function." [] synonym: "natural regulatory T cell" EXACT [] synonym: "natural regulatory T lymphocyte" EXACT [] synonym: "natural regulatory T-cell" EXACT [] synonym: "natural regulatory T-lymphocyte" EXACT [] synonym: "natural Treg" EXACT [] synonym: "nTreg" EXACT [] is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell [Term] id: CL:0000904 name: central memory CD4-positive, alpha-beta T cell namespace: cell def: "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'central memory CD4+ T cell', but includes additional markers known to be expressed on central memory CD4+ T cells. synonym: "central CD4-positive, alpha-beta memory T cell" EXACT [] synonym: "central CD4-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "central CD4-positive, alpha-beta memory T-cell" EXACT [] synonym: "central CD4-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "central memory CD4+ T cell" BROAD [] synonym: "central memory CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "central memory CD4-positive, alpha-beta T-cell" EXACT [] synonym: "central memory CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0001204 ! CD4-positive, alpha-beta memory T cell, CD45RO-positive [Term] id: CL:0000905 name: effector memory CD4-positive, alpha-beta T cell namespace: cell def: "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'effector memory CD4+ T cell', but includes additional markers known to be expressed on effector memory CD4+ T cells. synonym: "effector CD4-positive, alpha-beta memory T cell" EXACT [] synonym: "effector CD4-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "effector CD4-positive, alpha-beta memory T-cell" EXACT [] synonym: "effector CD4-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "effector memory CD4+ T cell" BROAD [] synonym: "effector memory CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "effector memory CD4-positive, alpha-beta T-cell" EXACT [] synonym: "effector memory CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0001204 ! CD4-positive, alpha-beta memory T cell, CD45RO-positive [Term] id: CL:0000906 name: activated CD8-positive, alpha-beta T cell namespace: cell def: "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, CD25-positive, and CCR7-negative." [] synonym: "activated CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "activated CD8-positive, alpha-beta T-cell" EXACT [] synonym: "activated CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell [Term] id: CL:0000907 name: central memory CD8-positive, alpha-beta T cell namespace: cell def: "CD8-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'central memory CD8+ T cell', but includes additional markers known to be expressed on central memory CD8+ T cells. synonym: "central CD8-positive, alpha-beta memory T cell" EXACT [] synonym: "central CD8-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "central CD8-positive, alpha-beta memory T-cell" EXACT [] synonym: "central CD8-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "central memory CD8+ T cell" BROAD [] synonym: "central memory CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "central memory CD8-positive, alpha-beta T-cell" EXACT [] synonym: "central memory CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0001203 ! CD8-positive, alpha-beta memory T cell, CD45RO-positive [Term] id: CL:0000908 name: CD8-positive, alpha-beta cytokine secreting effector T cell namespace: cell def: "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive, that secretes cytokines." [] synonym: "CD8-positive, alpha-beta cytokine secreting effector T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta cytokine secreting effector T-cell" EXACT [] synonym: "CD8-positive, alpha-beta cytokine secreting effector T-lymphocyte" EXACT [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell [Term] id: CL:0000909 name: CD8-positive, alpha-beta memory T cell namespace: cell def: "A CD8-positive, alpha-beta T cell that has differentiated into a memory T cell." [] synonym: "CD8-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta memory T-cell" EXACT [] synonym: "CD8-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "T.8Mem.Sp" RELATED [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell is_a: CL:0000813 ! memory T cell property_value: http://purl.org/dc/elements/1.1/creator https://orcid.org/0000-0001-9990-8331 xsd:string [Term] id: CL:0000910 name: cytotoxic T cell namespace: cell def: "A mature T cell that differentiated and acquired cytotoxic function with the phenotype perforin-positive and granzyme-B positive." [] synonym: "cytotoxic T lymphocyte" EXACT [] synonym: "cytotoxic T-cell" EXACT [] synonym: "cytotoxic T-lymphocyte" EXACT [] xref: BTO:0000289 xref: CALOHA:TS-0190 xref: FMA:70573 is_a: CL:0000911 ! effector T cell [Term] id: CL:0000911 name: effector T cell namespace: cell def: "A differentiated T cell with ability to traffic to peripheral tissues and is capable of mounting a specific immune response." [] synonym: "effector T lymphocyte" EXACT [] synonym: "effector T-cell" EXACT [] synonym: "effector T-lymphocyte" EXACT [] is_a: CL:0002419 ! mature T cell [Term] id: CL:0000912 name: helper T cell namespace: cell def: "A effector T cell that provides help in the form of secreted cytokines to other immune cells." [] synonym: "helper T lymphocyte" EXACT [] synonym: "helper T-cell" EXACT [] synonym: "helper T-lymphocyte" EXACT [] synonym: "T-helper cell" EXACT [] xref: BTO:0002417 is_a: CL:0000911 ! effector T cell [Term] id: CL:0000913 name: effector memory CD8-positive, alpha-beta T cell namespace: cell def: "CD8-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'effector memory CD8+ T cell', but includes additional markers known to be expressed on effector memory CD8+ T cells. synonym: "effector CD8-positive, alpha-beta memory T cell" EXACT [] synonym: "effector CD8-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "effector CD8-positive, alpha-beta memory T-cell" EXACT [] synonym: "effector CD8-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "effector memory CD8+ T cell" BROAD [] synonym: "effector memory CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "effector memory CD8-positive, alpha-beta T-cell" EXACT [] synonym: "effector memory CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0001203 ! CD8-positive, alpha-beta memory T cell, CD45RO-positive [Term] id: CL:0000914 name: immature NK T cell namespace: cell def: "An immature alpha-beta T-cell that express Egr2. These cells give rise to T cells expressing NK markers." [] synonym: "immature NK T lymphocyte" EXACT [] synonym: "immature NK T-cell" EXACT [] synonym: "immature NK T-lymphocyte" EXACT [] synonym: "immature NKT cell" EXACT [] is_a: CL:0000790 ! immature alpha-beta T cell [Term] id: CL:0000915 name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell namespace: cell def: "An alpha-beta intraepithelial T cell with the phenotype CD8-alpha-alpha-positive located in the columnar epithelium of the gastrointestinal tract. These cells have a memory phenotype of CD2-negative and CD5-negative." [] synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T-lymphocyte" EXACT [] is_a: CL:0000797 ! alpha-beta intraepithelial T cell [Term] id: CL:0000916 name: dendritic epidermal T cell namespace: cell def: "A mature gamma-delta T cell located in the epidermis that regulates wound healing." [] comment: In mice, DETC have an invariant T cell receptor. synonym: "dendritic epidermal T lymphocyte" EXACT [] synonym: "dendritic epidermal T-cell" EXACT [] synonym: "dendritic epidermal T-lymphocyte" EXACT [] synonym: "DETC" EXACT [] is_a: CL:0000800 ! mature gamma-delta T cell [Term] id: CL:0000917 name: Tc1 cell namespace: cell def: "A CD8-positive, alpha-beta positive T cell that has the phenotype T-bet-positive, eomesodermin-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'Tc1 CD8+ T cell', but its logical definition includes additional known characteristics of Tc1 T cells. synonym: "CD8-positive Th1 cell" EXACT [] synonym: "T-cytotoxic T cell type 1" EXACT [] synonym: "Tc1 CD8+ T cell" EXACT [] synonym: "Tc1 T cell" EXACT [] synonym: "Tc1 T lymphocyte" EXACT [] synonym: "Tc1 T-cell" EXACT [] synonym: "Tc1 T-lymphocyte" EXACT [] synonym: "Th1 CD8-positive T cell" EXACT [] synonym: "Th1 non-TFH CD8-positive T cell" EXACT [] xref: BTO:0004793 xref: BTO:0004888 xref: FMA:84793 is_a: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell [Term] id: CL:0000918 name: Tc2 cell namespace: cell def: "A CD8-positive, alpha-beta positive T cell expressing GATA-3 and secreting IL-4." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'non-Tc1/Tc17 CD8+ T cell' (see CL:0001052), but includes the additional necessary and sufficient conditions to allow classification as a Tc2 T cell. synonym: "CD8-positive Th2 cell" EXACT [] synonym: "T-cytotoxic T cell type 2" EXACT [] synonym: "Tc2 T cell" EXACT [] synonym: "Tc2 T lymphocyte" EXACT [] synonym: "Tc2 T-cell" EXACT [] synonym: "Tc2 T-lymphocyte" EXACT [] synonym: "Th2 CD8-positive T cell" EXACT [] synonym: "Th2 non-TFH CD8-positive T cell" EXACT [] xref: BTO:0004794 xref: FMA:84794 is_a: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell is_a: CL:0001052 ! CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell [Term] id: CL:0000919 name: CD8-positive, CD25-positive, alpha-beta regulatory T cell namespace: cell def: "A CD8-positive alpha beta-positive T cell with the phenotype FoxP3-positive and having suppressor function." [] synonym: "CD8+CD25+ T cell" EXACT [] synonym: "CD8+CD25+ T lymphocyte" EXACT [] synonym: "CD8+CD25+ T(reg)" EXACT [] synonym: "CD8+CD25+ T-cell" EXACT [] synonym: "CD8+CD25+ T-lymphocyte" EXACT [] synonym: "CD8+CD25+ Treg" EXACT [] synonym: "CD8-positive, CD25-positive Treg" EXACT [] synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T-lymphocyte" EXACT [] is_a: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell [Term] id: CL:0000920 name: CD8-positive, CD28-negative, alpha-beta regulatory T cell namespace: cell def: "CD8-positive, alpha-beta positive regulatory T cell with the phenotype CD28-negative and FoxP3-positive." [] synonym: "CD8+CD28- T cell" EXACT [] synonym: "CD8+CD28- T lymphocyte" EXACT [] synonym: "CD8+CD28- T(reg)" EXACT [] synonym: "CD8+CD28- T-cell" EXACT [] synonym: "CD8+CD28- T-lymphocyte" EXACT [] synonym: "CD8+CD28- Treg" EXACT [] synonym: "CD8-positive, CD28-negative T(reg)" EXACT [] synonym: "CD8-positive, CD28-negative Treg" EXACT [] synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T-cell" EXACT [] synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T-lymphocyte" EXACT [] is_a: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell [Term] id: CL:0000921 name: type I NK T cell namespace: cell def: "An alpha-beta T cell expressing NK cell markers that is CD1d restricted and expresses specific V-alpha chains. NK T cells of this type recognize the glycolipid alpha-galactosylceramide in the context of CD1d." [] comment: In mouse the canonical TCR is V-alpha-14, and in humans it is V-alpha 24. synonym: "classical NK T cell" EXACT [] synonym: "invariant NK T cell" RELATED [] synonym: "type I NK T lymphocyte" EXACT [] synonym: "type I NK T-cell" EXACT [] synonym: "type I NK T-lymphocyte" EXACT [] synonym: "type I NKT cell" EXACT [] is_a: CL:0000814 ! mature NK T cell [Term] id: CL:0000922 name: type II NK T cell namespace: cell def: "An alpha-beta T cell expressing NK call markers that is CD1d restricted and expresses a diverse TCR repertoire. Type II NKT cells do not become activated by alpha-galactosylceramide when presented by CD1d." [] synonym: "type II NK T lymphocyte" EXACT [] synonym: "type II NK T-cell" EXACT [] synonym: "type II NK T-lymphocyte" EXACT [] synonym: "type II NKT cell" EXACT [] is_a: CL:0000814 ! mature NK T cell [Term] id: CL:0000923 name: CD4-positive type I NK T cell namespace: cell def: "A type I NK T cell that has the phenotype CD4-positive." [] synonym: "CD4-positive type I NK T lymphocyte" EXACT [] synonym: "CD4-positive type I NK T-cell" EXACT [] synonym: "CD4-positive type I NK T-lymphocyte" EXACT [] synonym: "CD4-positive type I NKT cell" EXACT [] synonym: "NKT.4+.SP" NARROW [] is_a: CL:0000921 ! type I NK T cell [Term] id: CL:0000924 name: CD4-negative, CD8-negative type I NK T cell namespace: cell def: "A type I NK T cell that has the phenotype CD4-negative and CD8-negative." [] synonym: "CD4-negative, CD8-negative type I NK T lymphocyte" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-cell" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte" EXACT [] synonym: "CD4-negative, CD8-negative type I NKT cell" EXACT [] synonym: "NKT.4-.Sp" NARROW [] is_a: CL:0000921 ! type I NK T cell [Term] id: CL:0000925 name: activated CD4-positive type I NK T cell namespace: cell def: "A type I NK T cell that has been recently activated, secretes interferon-gamma and IL-4, and has the phenotype CD4-positive, CD69-positive, and downregulated NK markers." [] synonym: "activated CD4-positive type I NK T lymphocyte" EXACT [] synonym: "activated CD4-positive type I NK T-cell" EXACT [] synonym: "activated CD4-positive type I NK T-lymphocyte" EXACT [] synonym: "activated CD4-positive type I NKT cell" EXACT [] is_a: CL:0000923 ! CD4-positive type I NK T cell [Term] id: CL:0000926 name: CD4-positive type I NK T cell secreting interferon-gamma namespace: cell def: "A mature NK T cell that secretes interferon-gamma and enhances type 1 immune responses." [] synonym: "CD4-positive type I NK T cell secreting IFN-gamma" EXACT [] synonym: "CD4-positive type I NK T lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-positive type I NK T-cell secreting interferon-gamma" EXACT [] synonym: "CD4-positive type I NK T-lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-positive type I NKT cell secreting interferon-gamma" EXACT [] is_a: CL:0000923 ! CD4-positive type I NK T cell [Term] id: CL:0000927 name: CD4-positive type I NK T cell secreting interleukin-4 namespace: cell def: "A mature NK T cell that predominantly secretes type 2 cytokines such as interleukin-4 and interleukin-13 and enhances type 2 immune responses." [] synonym: "CD4-positive type I NK T cell secreting IL-4" EXACT [] synonym: "CD4-positive type I NK T lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-positive type I NK T-cell secreting interleukin-4" EXACT [] synonym: "CD4-positive type I NK T-lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-positive type I NKT cell secreting interleukin-4" EXACT [] is_a: CL:0000923 ! CD4-positive type I NK T cell [Term] id: CL:0000928 name: activated CD4-negative, CD8-negative type I NK T cell namespace: cell def: "A type I NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has phenotype CD4-negative, CD8-negative, CD69-positive, and downregulated NK markers." [] synonym: "activated CD4-negative, CD8-negative type I NK T lymphocyte" EXACT [] synonym: "activated CD4-negative, CD8-negative type I NK T-cell" EXACT [] synonym: "activated CD4-negative, CD8-negative type I NK T-lymphocyte" EXACT [] synonym: "activated CD4-negative, CD8-negative type I NKT cell" EXACT [] is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell [Term] id: CL:0000929 name: CD4-negative, CD8-negative type I NK T cell secreting interferon-gamma namespace: cell def: "A mature NK T cell that secretes interferon-gamma and enhances Th1 immune responses." [] synonym: "CD4-negative, CD8-negative type I NK T cell secreting IFN-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-cell secreting interferon-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NKT cell secreting interferon-gamma" EXACT [] is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell [Term] id: CL:0000930 name: CD4-negative, CD8-negative type I NK T cell secreting interleukin-4 namespace: cell def: "A mature NK T cell that secretes interleukin-4 and enhances Th2 immune responses." [] synonym: "CD4-negative, CD8-negative type I NK T cell secreting IL-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-cell secreting interleukin-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NKT cell secreting interleukin-4" EXACT [] is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell [Term] id: CL:0000931 name: activated type II NK T cell namespace: cell def: "A type II NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has the phenotype CD69-positive and downregulated NK markers." [] synonym: "activated type II NK T lymphocyte" EXACT [] synonym: "activated type II NK T-cell" EXACT [] synonym: "activated type II NK T-lymphocyte" EXACT [] synonym: "activated type II NKT cell" EXACT [] is_a: CL:0000922 ! type II NK T cell [Term] id: CL:0000932 name: type II NK T cell secreting interferon-gamma namespace: cell def: "A type II NK T cell that has been recently activated, secretes interferon-gamma, and has the phenotype CD69-positive and downregulated NK markers." [] synonym: "type II NK T cell secreting IFN-gamma" EXACT [] synonym: "type II NK T lymphocyte secreting interferon-gamma" EXACT [] synonym: "type II NK T-cell secreting interferon-gamma" EXACT [] synonym: "type II NK T-lymphocyte secreting interferon-gamma" EXACT [] synonym: "type II NKT cell secreting interferon-gamma" EXACT [] is_a: CL:0000922 ! type II NK T cell [Term] id: CL:0000933 name: type II NK T cell secreting interleukin-4 namespace: cell def: "A type II NK T cell that has been recently activated, secretes interleukin-4, and has the phenotype CD69-positive and downregulated NK markers." [] synonym: "type II NK T cell secreting IL-4" EXACT [] synonym: "type II NK T lymphocyte secreting interleukin-4" EXACT [] synonym: "type II NK T-cell secreting interleukin-4" EXACT [] synonym: "type II NK T-lymphocyte secreting interleukin-4" EXACT [] synonym: "type II NKT cell secreting interleukin-4" EXACT [] is_a: CL:0000922 ! type II NK T cell [Term] id: CL:0000934 name: CD4-positive, alpha-beta cytotoxic T cell namespace: cell def: "A CD4-positive, alpha-beta T cell that has cytotoxic function." [] synonym: "CD4-positive, alpha-beta cytotoxic T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta cytotoxic T-cell" EXACT [] synonym: "CD4-positive, alpha-beta cytotoxic T-lymphocyte" EXACT [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell [Term] id: CL:0000935 name: CD4-negative, CD8-negative, alpha-beta intraepithelial T cell namespace: cell def: "A CD4-negative, CD8-negative, alpha-beta intraepithelial T cell that is found in the columnar epithelium of the gastrointestinal tract." [] synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T-lymphocyte" EXACT [] is_a: CL:0000797 ! alpha-beta intraepithelial T cell [Term] id: CL:0000937 name: pre-natural killer cell namespace: cell def: "Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, and CD117-positive. This cell type lacks expression of natural killer receptor proteins." [] comment: These cells are also reportedly CD7-low, CD10-negative, CD45RA-positive, alpha-4-beta-7 integrin-high. synonym: "pre-NK cell" EXACT [] is_a: CL:0000623 ! natural killer cell [Term] id: CL:0000938 name: CD16-negative, CD56-bright natural killer cell, human namespace: cell def: "NK cell that has the phenotype CD56-bright, CD16-negative, and CD84-positive with the function to secrete interferon-gamma but is not cytotoxic." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16-CD56bright NK cell'. Markers are associated with human cell types. synonym: "CD16-CD56bright NK cell" EXACT [] synonym: "CD16-negative, CD56-bright NK cell" EXACT [] synonym: "CD56-bright cytokine secreting natural killer cell" EXACT [] synonym: "CD56-bright cytokine secreting NK cell" EXACT [] is_a: CL:0000824 ! mature natural killer cell [Term] id: CL:0000939 name: CD16-positive, CD56-dim natural killer cell, human namespace: cell def: "A mature natural killer cell that has the phenotype CD56-low, CD16-positive and which is capable of cytotoxicity and cytokine production." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16+CD56+ NK cell'. Markers are associated with human cell types. synonym: "CD16+CD56+ NK cell" EXACT [] synonym: "CD16-positive, CD56-dim NK cell" EXACT [] synonym: "CD16-positive, CD56-low natural killer cell" EXACT [] synonym: "CD16-positive, CD56-low NK cell" EXACT [] synonym: "CD16-positive, CD56-positive natural killer cell" EXACT [] synonym: "CD16-positive, CD56-positive NK cell" EXACT [] synonym: "cytotoxic CD56-dim natural killer cell" EXACT [] synonym: "cytotoxic CD56-dim NK cell" EXACT [] is_a: CL:0000824 ! mature natural killer cell [Term] id: CL:0000940 name: mucosal invariant T cell namespace: cell def: "An alpha-beta T cell that is found in the lamina propria of mucosal tissues and is restricted by the MR-1 molecule." [] synonym: "mucosal invariant T lymphocyte" EXACT [] synonym: "mucosal invariant T-cell" EXACT [] synonym: "mucosal invariant T-lymphocyte" EXACT [] is_a: CL:0000791 ! mature alpha-beta T cell [Term] id: CL:0000941 name: thymic conventional dendritic cell namespace: cell def: "A dendritic cell arising in thymus that has the phenotype CD11c-positive, CD11b-negative, and CD45RA-negative." [] comment: In the mouse this cell expresses CD8-alpha-alpha. is_a: CL:0000990 ! conventional dendritic cell relationship: part_of UBERON:0002370 ! thymus [Term] id: CL:0000942 name: thymic plasmacytoid dendritic cell namespace: cell def: "A plasmacytoid dendritic cell developing in the thymus with phenotype CD11c-negative or low, CD45RA-positive, CD11b-negative, and CD123-positive." [] is_a: CL:0000784 ! plasmacytoid dendritic cell [Term] id: CL:0000943 name: Be1 Cell namespace: cell def: "A Be cell that facilitates development of T-helper 1 (Th1) phenotype in CD4-positive T cells, and secretes high levels of interleukin-2, tumor necrosis factor-alpha and interferon-gamma." [] comment: Be1 cells are also reportedly capable of secreting IL-6, IL-10, and IL-12. They are also reportedly CD11b-negative and B220-positive. synonym: "B effector 1 cell" EXACT [] synonym: "B effector cell type 1" RELATED [] is_a: CL:0000968 ! Be cell [Term] id: CL:0000944 name: Be2 cell namespace: cell def: "A Be cell that facilitates development of T-helper 2 (Th2) phenotype T cells, and secretes high levels of interleukin-2, interleukin-10, interleukin-4, and interleukin-6." [] comment: Be2 cells are also reportedly capable of secreting IL-13 and TNF. They are also reportedly CD11b-negative and B220-positive. synonym: "B effector 2 cell" EXACT [] synonym: "B effector cell type 2" RELATED [] is_a: CL:0000968 ! Be cell [Term] id: CL:0000945 name: lymphocyte of B lineage namespace: cell def: "A lymphocyte of B lineage with the commitment to express an immunoglobulin complex." [] comment: Types of B lineage lymphocytes include B cells and antibody secreting cells (plasmablasts and plasma cells). Lymphocytes of B cell lineage can be distinguished from those of T cell lineage by their lack of CD3e (as part of the T cell receptor complex). is_a: CL:0000542 ! lymphocyte [Term] id: CL:0000946 name: antibody secreting cell namespace: cell def: "A lymphocyte of B lineage that is devoted to secreting large amounts of immunoglobulin." [] is_a: CL:0000945 ! lymphocyte of B lineage [Term] id: CL:0000947 name: IgE plasma cell namespace: cell def: "A long lived plasma cell that secretes IgE." [] is_a: CL:0000974 ! long lived plasma cell [Term] id: CL:0000948 name: IgE memory B cell namespace: cell def: "A class switched memory B cell that expresses IgE on the cell surface." [] synonym: "IgE memory B lymphocyte" EXACT [] synonym: "IgE memory B-cell" EXACT [] synonym: "IgE memory B-lymphocyte" EXACT [] synonym: "memory IgE B cell" EXACT [] synonym: "memory IgE B lymphocyte" EXACT [] synonym: "memory IgE B-cell" EXACT [] synonym: "memory IgE B-lymphocyte" EXACT [] is_a: CL:0000972 ! class switched memory B cell [Term] id: CL:0000949 name: IgD plasmablast namespace: cell def: "A plasmablast that secretes IgD, and which occur in a small proportion of B cells in the adult." [] is_a: CL:0000980 ! plasmablast [Term] id: CL:0000950 name: IgE plasmablast namespace: cell def: "A plasmablast that secretes IgE." [] is_a: CL:0000980 ! plasmablast [Term] id: CL:0000951 name: IgE short lived plasma cell namespace: cell def: "A short lived plasma cell that secretes IgE." [] is_a: CL:0000975 ! short lived plasma cell [Term] id: CL:0000952 name: preBCR-positive large pre-B-II cell namespace: cell def: "An preBRC-positive large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-positive, composed of surrogate light chain protein (SL), which is composed of VpreB , Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu) on the cell surface." [] is_a: CL:0000957 ! large pre-B-II cell [Term] id: CL:0000953 name: preBCR-negative large pre-B-II cell namespace: cell def: "A pre-BCR-negative large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-negative, composed of surrogate light chain protein (SL), which is composed of VpreB and Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu), on the cell surface, and lack a DNA rearrangement of immunoglobulin light chain genes." [] is_a: CL:0000957 ! large pre-B-II cell [Term] id: CL:0000954 name: small pre-B-II cell namespace: cell def: "A small pre-B-II cell is a pre-B-II cell that is Rag1-positive, Rag2-positive, pre-BCR-negative, and BCR-negative, is not proliferating, and carries a DNA rearrangement of one or more immunoglobulin light chain genes." [] comment: Small pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-negative, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. synonym: "small pre-BII cell" EXACT [] is_a: CL:0000955 ! pre-B-II cell [Term] id: CL:0000955 name: pre-B-II cell namespace: cell def: "A pre-B-II cell is a precursor B cell that expresses immunoglobulin mu heavy chain (IgHmu+), and lack expression of CD34, TdT, immunoglobulin kappa light chain and immunoglobulin lambda light chain." [] comment: pre-B-II cell are also reportedly CD19-positive, CD22-positive, CD38-positive, CD45-positive, and CD48-positive. synonym: "pre-B-lymphocyte" EXACT [] synonym: "pre-BII cell" EXACT [] xref: BTO:0001133 xref: CALOHA:TS-0819 is_a: CL:0000817 ! precursor B cell [Term] id: CL:0000956 name: pre-B-I cell namespace: cell def: "A pre-B-I cell is a precursor B cell that expresses CD34 and surrogate immunoglobulin light chain (VpreB , Lambda 5 (mouse)/14.1 (human)) on the cell surface, and TdT, Rag1,and Rag2 intracellularly. Cell type carries a D-JH DNA rearrangement, and lacks expression of immunglobulin heavy chain protein." [] comment: Human pre-B-I cells are reportedly CD10-positive, CD19-positive, CD22-positive, CD38-positive, CD45-low, CD79a-positive, CD127-negative, pre-BCR-negative, IgM-negative, IgD-negative, and Tdt-positive. Transcription factors expressed: Pax5-positive. synonym: "pre-BI cell" EXACT [] synonym: "pro-B cell (Philadelphia nomenclature)" RELATED [] is_a: CL:0000817 ! precursor B cell [Term] id: CL:0000957 name: large pre-B-II cell namespace: cell def: "A large pre-B-II cell is a pre-B-II cell that is proliferating and is Rag1-negative and Rag2-negative." [] comment: Large pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-positive, pre-BCR-positive, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. synonym: "large pre-B cell" BROAD [] synonym: "large pre-BII cell" EXACT [] is_a: CL:0000955 ! pre-B-II cell [Term] id: CL:0000958 name: T1 B cell namespace: cell def: "A transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen. This cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative, and CD93-positive. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-negative." [] comment: T1 B cells are also reportedly CD10-negative/positive??, CD20-positive, CD24-positive, CD38-positive, CD48-positive, CD84-positive, CD150-positive, CD244-negative, and CD352-positive. synonym: "T1 B lymphocyte" EXACT [] synonym: "T1 B-cell" EXACT [] synonym: "T1 B-lymphocyte" EXACT [] synonym: "transitional stage 1 B cell" EXACT [] is_a: CL:0000818 ! transitional stage B cell [Term] id: CL:0000959 name: T2 B cell namespace: cell def: "A transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, CD93-positive and is located in the splenic B follicles. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-positive." [] comment: T2 B cells are also reportedly CD20-positive, CD24-positive, CD38-positive, CD48-positive, CD84-positive, CD150-positive, CD244-negative, and CD352-positive. synonym: "T2 B lymphocyte" EXACT [] synonym: "T2 B-cell" EXACT [] synonym: "T2 B-lymphocyte" EXACT [] synonym: "transitional stage 2 B cell" EXACT [] is_a: CL:0000818 ! transitional stage B cell [Term] id: CL:0000960 name: T3 B cell namespace: cell def: "A transitional stage B cell that expresses surface IgM and IgD, and CD62L. This cell type appears to be an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, CD62L-positive, and CD93-positive. This cell type has also been described as IgM-low, CD19-positive, B220-positive, AA4-positive, and CD23-positive (i.e. this cell-type is distinguished from T2 cells by surface expression of IgM)." [] synonym: "An1 B cell" EXACT [] synonym: "T3 B lymphocyte" EXACT [] synonym: "T3 B-cell" EXACT [] synonym: "T3 B-lymphocyte" EXACT [] synonym: "transitional stage 3 B cell" EXACT [] is_a: CL:0000818 ! transitional stage B cell [Term] id: CL:0000961 name: Bm1 B cell namespace: cell def: "A follicular B cell that is IgD-positive, CD23-negative, and CD38-negative. This naive cell type is activated in the extrafollicular areas through interaction with interdigitating dendritic cells and antigen-specific CD4-positive T cells." [] comment: These cells are also reportedly CD10-negative, CD39-positive, CD44-positive, CD71-negative, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative. synonym: "Bm1 B lymphocyte" EXACT [] synonym: "Bm1 B-cell" EXACT [] synonym: "Bm1 B-lymphocyte" EXACT [] is_a: CL:0000843 ! follicular B cell is_a: CL:0002056 ! Fraction F mature B cell [Term] id: CL:0000962 name: Bm2 B cell namespace: cell def: "A follicular B cell that is IgD-positive and CD23-positive and CD38-positive. This naive cell type is activated in the extrafollicular areas via interaction with dendritic cells and antigen specific T cells." [] comment: These cells are also CD10-negative, CD39-positive, CD44-positive, CD71-negative, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative. synonym: "Bm2 B lymphocyte" EXACT [] synonym: "Bm2 B-cell" EXACT [] synonym: "Bm2 B-lymphocyte" EXACT [] is_a: CL:0000843 ! follicular B cell [Term] id: CL:0000963 name: Bm3-delta B cell namespace: cell def: "A germinal center B cell that develops from a Bm3 B cell. This cell has the phenotype IgM-negative, IgD-positive, and CD38-positive." [] synonym: "Bm3-delta B lymphocyte" EXACT [] synonym: "Bm3-delta B-cell" EXACT [] synonym: "Bm3-delta B-lymphocyte" EXACT [] is_a: CL:0000844 ! germinal center B cell [Term] id: CL:0000964 name: Bm2' B cell namespace: cell def: "A germinal center B cell that founds a germinal center, and has the phenotype IgD-positive, CD38-positive, and CD23-negative." [] comment: Bm2' B cells are also reportedly CD10-positive, CD39-negative, CD44-negative, CD71-positive, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative. synonym: "Bm2' B lymphocyte" EXACT [] synonym: "Bm2' B-cell" EXACT [] synonym: "Bm2-prime B cell" EXACT [] synonym: "Bm2-prime B-lymphocyte" EXACT [] synonym: "germinal center founder cell" RELATED [] is_a: CL:0000844 ! germinal center B cell [Term] id: CL:0000965 name: Bm3 B cell namespace: cell def: "A germinal center B cell that is rapidly dividing and has the phenotype IgD-negative, CD38-positive, and CD77-positive. Somatic hypermutation of the immunoglobulin V gene region can occur during proliferation of this cell type." [] comment: Bm3 B cells are also reportedly CD10-positive, CD23-negative, CD39-negative, CD44-negative, CD71-positive, and CD77-positive. synonym: "Bm3 B lymphocyte" EXACT [] synonym: "Bm3 B-cell" EXACT [] synonym: "Bm3 B-lymphocyte" EXACT [] synonym: "centroblast" RELATED [] is_a: CL:0000844 ! germinal center B cell [Term] id: CL:0000966 name: Bm4 B cell namespace: cell def: "A germinal center B cell that has the phenotype CD77-negative, IgD-negative, and CD38-positive. These cells have undergone somatic mutation of the B cell receptor." [] comment: Bm4 B cells are also reportedly CD10-positive, CD23-negative, CD39-negative, CD44-positive, and CD71-positive. synonym: "Bm4 B lymphocyte" EXACT [] synonym: "Bm4 B-cell" EXACT [] synonym: "Bm4 B-lymphocyte" EXACT [] synonym: "centrocyte" RELATED [] is_a: CL:0000844 ! germinal center B cell [Term] id: CL:0000967 name: Bm5 B cell namespace: cell def: "A memory B cell arising in the germinal center that is IgD-negative and has undergone somatic mutation of the variable region of the immunoglobulin heavy and light chain genes." [] comment: Bm5 B cells are also reportedly CD10-positive, CD23-negative, CD38-negative, CD39-positive, CD44-positive, CD71-positive, and CD77-negative. synonym: "Bm5 B lymphocyte" EXACT [] synonym: "Bm5 B-cell" EXACT [] synonym: "Bm5 B-lymphocyte" EXACT [] is_a: CL:0001053 ! IgD-negative memory B cell [Term] id: CL:0000968 name: Be cell namespace: cell def: "A mature B cell that produces cytokines that can influence CD4 T cell differentiation." [] synonym: "B effector cell" EXACT [] synonym: "effector B cell" EXACT [] synonym: "effector B lymphocyte" EXACT [] synonym: "effector B-cell" EXACT [] synonym: "effector B-lymphocyte" EXACT [] is_a: CL:0000785 ! mature B cell [Term] id: CL:0000969 name: regulatory B cell namespace: cell def: "A mature B cell that has the phenotype CD1d-positive and expresses interleukin-10. This cell type has been associated with suppression of chronic inflammatory responses and T cell responses." [] comment: Regulatory B cells reportedly represent 1-2% of the spleen and 7-8% of the peritoneal B220-positive cells in mice. They are also found in the bone marrow, lymph node, and blood of mice. These cells are also reportedly capable of secreting IL-10 and are reportedly CD5-positive, CD21-positive, CD24-positive, CD93-negative, B220-positive, IgM-positive, and IgD-positive. synonym: "B(reg)" EXACT [] synonym: "B10 cell" EXACT [] synonym: "Breg" EXACT [] synonym: "regulatory B lymphocyte" EXACT [] synonym: "regulatory B-cell" EXACT [] synonym: "regulatory B-lymphocyte" EXACT [] is_a: CL:0000785 ! mature B cell [Term] id: CL:0000970 name: unswitched memory B cell namespace: cell def: "An unswitched memory B cell is a memory B cell that has the phenotype IgM-positive, IgD-positive, CD27-positive, CD138-negative, IgG-negative, IgE-negative, and IgA-negative." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'IgD+ memory B cell'. Per DSD: Unswitched memory B cells are also reportedly CD48-positive, CD84-positive, CD229-positive, and CD352-positive. synonym: "IgD+ memory B cell" BROAD [] synonym: "non-class-switched memory B cell" EXACT [] synonym: "unswitched memory B lymphocyte" EXACT [] synonym: "unswitched memory B-cell" EXACT [] synonym: "unswitched memory B-lymphocyte" EXACT [] is_a: CL:0000787 ! memory B cell [Term] id: CL:0000971 name: IgM memory B cell namespace: cell def: "An IgM memory B cell is an unswitched memory B cell with the phenotype IgM-positive and IgD-negative." [] comment: IgM memory B cells are also reportedly CD1c-positive, CD95-positive, CD80-positive, CD84-positive, CD86-positive, CD150-negative, CD229-positive, CD289-positive, and CD290-positive. Transcription factors: Notch2-positive, PAX5-positive, SpiB-positive, Ets1-positive, and OBF1-positive. synonym: "IgM memory B lymphocyte" EXACT [] synonym: "IgM memory B-cell" EXACT [] synonym: "IgM memory B-lymphocyte" EXACT [] synonym: "memory IgM B cell" EXACT [] synonym: "memory IgM B lymphocyte" EXACT [] synonym: "memory IgM B-cell" EXACT [] synonym: "memory IgM B-lymphocyte" EXACT [] is_a: CL:0001053 ! IgD-negative memory B cell [Term] id: CL:0000972 name: class switched memory B cell namespace: cell def: "A class switched memory B cell is a memory B cell that has undergone Ig class switching and therefore is IgM-negative on the cell surface. These cells are CD27-positive and have either IgG, IgE, or IgA on the cell surface." [] comment: Per DSD: Class switched memory B cells are also reportedly CD48-positive, CD229-positive, and CD352-positive. synonym: "class switched memory B lymphocyte" EXACT [] synonym: "class switched memory B-cell" EXACT [] synonym: "class switched memory B-lymphocyte" EXACT [] is_a: CL:0000787 ! memory B cell [Term] id: CL:0000973 name: IgA memory B cell namespace: cell def: "A class switched memory B cell that expresses IgA." [] comment: IgA memory B cell are also reportedly RORalpha-positive. synonym: "IgA memory B lymphocyte" EXACT [] synonym: "IgA memory B-cell" EXACT [] synonym: "IgA memory B-lymphocyte" EXACT [] synonym: "memory IgA B cell" EXACT [] synonym: "memory IgA B lymphocyte" EXACT [] synonym: "memory IgA B-cell" EXACT [] synonym: "memory IgA B-lymphocyte" EXACT [] is_a: CL:0000972 ! class switched memory B cell [Term] id: CL:0000974 name: long lived plasma cell namespace: cell def: "A fully differentiated plasma cell that lives for years, as opposed to months, secretes immunoglobulin, and has the phenotype weakly CD19-positive, CD20-negative, CD38-negative, strongly CD138-positive, MHC Class II-negative, surface immunoglobulin-negative, IgD-negative, and strongly CXCR4-positive. The majority of these cells of this type reside in the bone marrow." [] is_a: CL:0000786 ! plasma cell [Term] id: CL:0000975 name: short lived plasma cell namespace: cell def: "A fully differentiated plasma cell that lives for months." [] is_a: CL:0000786 ! plasma cell [Term] id: CL:0000976 name: IgA short lived plasma cell namespace: cell def: "A short lived plasma cell that secretes IgA. These cells may be found in the bone marrow as well as in the mucosal immune system." [] is_a: CL:0000975 ! short lived plasma cell [Term] id: CL:0000977 name: IgG short lived plasma cell namespace: cell def: "A short lived plasma cell that secretes IgG." [] is_a: CL:0000975 ! short lived plasma cell [Term] id: CL:0000978 name: IgM short lived plasma cell namespace: cell def: "A short lived plasma cell that secretes IgM." [] is_a: CL:0000975 ! short lived plasma cell [Term] id: CL:0000979 name: IgG memory B cell namespace: cell def: "An IgG memory B cell is a class switched memory B cell that is class switched and expresses IgG on the cell surface." [] synonym: "IgG memory B lymphocyte" EXACT [] synonym: "IgG memory B-cell" EXACT [] synonym: "IgG memory B-lymphocyte" EXACT [] synonym: "memory IgG B cell" EXACT [] synonym: "memory IgG B lymphocyte" EXACT [] synonym: "memory IgG B-cell" EXACT [] synonym: "memory IgG B-lymphocyte" EXACT [] is_a: CL:0000972 ! class switched memory B cell [Term] id: CL:0000980 name: plasmablast namespace: cell def: "An activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'plasmablast'. Plasmablasts are also reportedly CD48-positive, CD63-positive, CD229-positive, CD270-positive, CD319-positive, CD352-positive, CD361-positive, and IgD-negative. synonym: "CD20-negative B cell" BROAD [] synonym: "CD27-positive, CD38-positive, CD20-negative B cell" EXACT [] xref: FMA:84371 is_a: CL:0000785 ! mature B cell is_a: CL:0000946 ! antibody secreting cell [Term] id: CL:0000981 name: double negative memory B cell namespace: cell def: "A memory B cell with the phenotype IgD-negative and CD27-negative." [] synonym: "dn memory B cell" EXACT [] synonym: "dn memory B lymphocyte" EXACT [] synonym: "dn memory B-cell" EXACT [] synonym: "dn memory B-lymphocyte" EXACT [] synonym: "double negative memory B lymphocyte" EXACT [] synonym: "double negative memory B-cell" EXACT [] synonym: "double negative memory B-lymphocyte" EXACT [] is_a: CL:0001053 ! IgD-negative memory B cell [Term] id: CL:0000982 name: IgG plasmablast namespace: cell def: "A plasmablast that secretes IgG." [] is_a: CL:0000980 ! plasmablast [Term] id: CL:0000983 name: IgM plasmablast namespace: cell def: "A plasmablast that secretes IgM." [] is_a: CL:0000980 ! plasmablast [Term] id: CL:0000984 name: IgA plasmablast namespace: cell def: "A plasmablast that secretes IgA." [] is_a: CL:0000980 ! plasmablast [Term] id: CL:0000985 name: IgG plasma cell namespace: cell def: "A fully differentiated plasma cell that secretes IgG." [] is_a: CL:0000974 ! long lived plasma cell [Term] id: CL:0000986 name: IgM plasma cell namespace: cell def: "A fully differentiated plasma cell that secretes IgM." [] is_a: CL:0000974 ! long lived plasma cell [Term] id: CL:0000987 name: IgA plasma cell namespace: cell def: "A fully differentiated plasma cell that secretes IgA." [] is_a: CL:0000974 ! long lived plasma cell [Term] id: CL:0000989 name: CD11c-low plasmacytoid dendritic cell namespace: cell def: "CD11c-low plasmacytoid dendritic cell is a leukocyte that is CD11c-low, CD45R-positive, GR1-positive and CD11b-negative." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000001)(PMID:19243617). These cells are CD281-positive (TLR1), CD282-positive (TLR2), CD285-positive (TLR5), CD286-positive (TLR6), and CD288-positive (TLR8). is_a: CL:0000784 ! plasmacytoid dendritic cell [Term] id: CL:0000990 name: conventional dendritic cell namespace: cell def: "Conventional dendritic cell is a dendritic cell that is CD11c-high." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000003)(PMID:19243617) These cells are also CD20-negative, MHCII-positive. synonym: "cDC" EXACT [] synonym: "DC1" EXACT [] synonym: "dendritic reticular cell" EXACT [] synonym: "interdigitating cell" BROAD [] synonym: "type 1 DC" EXACT [] synonym: "veiled cell" BROAD [] xref: FMA:84191 is_a: CL:0000451 ! dendritic cell [Term] id: CL:0000991 name: CD11c-negative plasmacytoid dendritic cell namespace: cell def: "CD11c-negative plasmacytoid dendritic cell is a leukocyte is CD11c-negative, CD45RA-positive, CD85g-positive(ILT7), CD123-positive, CD303-positive." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000004)(PMID:19243617). These cells are CD281-positive (TLR1), CD286-positive (TLR6), and CD290-positive (TLR10). synonym: "CD303-positive dendritic cell" EXACT [] is_a: CL:0000784 ! plasmacytoid dendritic cell [Term] id: CL:0000992 name: immature CD11c-low plasmacytoid dendritic cell namespace: cell def: "Immature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD80-low and CD86-low." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000006)(PMID:19243617). is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000989 ! CD11c-low plasmacytoid dendritic cell [Term] id: CL:0000993 name: mature CD11c-low plasmacytoid dendritic cell namespace: cell def: "Mature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD83-high and is CD80-positive, CD86-positive, and MHCII-positive." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000007)(PMID:19243617). is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000989 ! CD11c-low plasmacytoid dendritic cell [Term] id: CL:0000994 name: immature CD11c-negative plasmacytoid dendritic cell namespace: cell def: "Immature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-negative, CD86-low and MHCII-low." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000008)(PMID:19243617). is_a: CL:0000991 ! CD11c-negative plasmacytoid dendritic cell [Term] id: CL:0000996 name: mature CD11c-negative plasmacytoid dendritic cell namespace: cell def: "Mature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-high, CD86-high, MHCII-high and is CD83-positive." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000009)(PMID:19243617). is_a: CL:0000991 ! CD11c-negative plasmacytoid dendritic cell [Term] id: CL:0000997 name: immature CD8_alpha-negative CD11b-positive dendritic cell namespace: cell def: "Immature CD8_alpha-negative CD11b-positive dendritic cell is a CD8_alpha-negative CD11b-positive dendritic cell that is CD80-low, CD86-low, and MHCII-low." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000010)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0000999 ! CD4-positive CD11b-positive dendritic cell [Term] id: CL:0000998 name: CD8_alpha-negative CD11b-negative dendritic cell namespace: cell def: "CD8_alpha-negative CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative CD8_alpha-negative and is CD205-positive. This cell is able to cross- present antigen to CD8-alpha-positive T cells." [] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000011)(PMID:19243617). synonym: "DC.8-4-11b-" EXACT [] synonym: "triple negative dendritic cell" EXACT [] is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 ! conventional dendritic cell [Term] id: CL:0000999 name: CD4-positive CD11b-positive dendritic cell namespace: cell def: "CD8_alpha-negative CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-positive and is CD205-negative and CD8_alpha-negative." [] comment: Defined as having a disposition to secreting anti-inflammatory cytokines. These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000012)(PMID:19243617). synonym: "DC.4+" EXACT [] is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0002465 ! CD11b-positive dendritic cell [Term] id: CL:0001000 name: CD8_alpha-positive CD11b-negative dendritic cell namespace: cell def: "CD8_alpha-positive CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative and is CD205-positive and CD8_alpha-positive." [] comment: Cells are defined as having a disposition to secreting inflammatory cytokines. Originally described in the dendritic cell ontology (DC_CL:0000013)(PMID:19243617). synonym: "DC.8+" EXACT [] is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 ! conventional dendritic cell [Term] id: CL:0001001 name: immature CD8_alpha-negative CD11b-negative dendritic cell namespace: cell def: "Immature CD8_alpha-negative CD11b-negative dendritic cell is a CD8_alpha-negative CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low." [] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000014)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0000998 ! CD8_alpha-negative CD11b-negative dendritic cell [Term] id: CL:0001002 name: mature CD8_alpha-negative CD11b-negative dendritic cell namespace: cell def: "Mature CD8_alpha-negative CD11b-negative dendritic cell is a CD8_alpha-negative CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [] comment: These markers are associated with mouse cells. Defined as having a disposition to secretion of anti-inflammatory cytokines. Originally described in the dendritic cell ontology (DC_CL:0000015)(PMID:19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0000998 ! CD8_alpha-negative CD11b-negative dendritic cell [Term] id: CL:0001003 name: mature CD8_alpha-negative CD11b-positive dendritic cell namespace: cell def: "Mature CD8_alpha-negative CD11b-positive dendritic cell is a CD8_alpha-negative CD11b-positive dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000016)(PMID:19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0000999 ! CD4-positive CD11b-positive dendritic cell [Term] id: CL:0001004 name: immature CD8_alpha-positive CD11b-negative dendritic cell namespace: cell def: "Immature CD8_alpha-positive CD11b-negative dendritic cell is a CD8_alpha-positive CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000017)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001000 ! CD8_alpha-positive CD11b-negative dendritic cell [Term] id: CL:0001005 name: mature CD8_alpha-positive CD11b-negative dendritic cell namespace: cell def: "Mature CD8_alpha-positive CD11b-negative dendritic cell is a CD8_alpha-positive CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000018)(PMID:19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001000 ! CD8_alpha-positive CD11b-negative dendritic cell [Term] id: CL:0001006 name: dermal dendritic cell namespace: cell def: "Dermal dendritic cell is a conventional dendritic cell that is CD11b-positive, CD205-positive and CD8 alpha-negative." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000019)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD285-positive (TLR5), CD288-positive (TLR8), and CD289-positive (TLR9). xref: BTO:0004812 is_a: CL:0002465 ! CD11b-positive dendritic cell [Term] id: CL:0001007 name: interstitial dendritic cell namespace: cell def: "Interstitial dendritic cell is a conventional dendritic cell that is CD11b-positive, CD1a-positive, CD206-positive, CD209-positive, and CD36-positive." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000020)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD286-positive (TLR6), CD288-positive (TLR8), and CD290-positive (TLR10). is_a: CL:0002465 ! CD11b-positive dendritic cell [Term] id: CL:0001009 name: immature dermal dendritic cell namespace: cell def: "Immature dermal dendritic cell is a dermal dendritic cell that is CD80-low, CD86-low, and MHCII-low." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000022)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001006 ! dermal dendritic cell [Term] id: CL:0001010 name: mature dermal dendritic cell namespace: cell def: "Mature dermal dendritic cell is a dermal dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000023)(PMID:19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001006 ! dermal dendritic cell [Term] id: CL:0001011 name: immature interstitial dendritic cell namespace: cell def: "Immature interstitial dendritic cell is a interstitial dendritic cell that is CD80-low, CD86-low, and MHCII-low." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000024)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001007 ! interstitial dendritic cell [Term] id: CL:0001013 name: mature interstitial dendritic cell namespace: cell def: "Mature interstitial dendritic cell is a interstitial dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000025)(PMID:19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001007 ! interstitial dendritic cell [Term] id: CL:0001014 name: CD1a-positive Langerhans cell namespace: cell def: "CD1a-positive Langerhans cell is a Langerhans_cell that is CD1a-positive and CD324-positive." [] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000026)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD284-positive (TLR4), CD286-positive (TLR6), CD287-positive (TLR7), and CD290-positive (TLR10). When activated, these cells are capable of producing IL-6, IL-8, and IL-15. synonym: "CD1a-LC" EXACT [] is_a: CL:0000453 ! Langerhans cell [Term] id: CL:0001015 name: CD8_alpha-low Langerhans cell namespace: cell def: "CD8_alpha-low Langerhans cell is a Langerhans cell that is CD205-high and is CD8_alpha-low." [] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000027)(PMID:19243617). They are also CD205-high, CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD285-positive (TLR5), CD286-positive (TLR6), and CD289-positive (TLR9). is_a: CL:0000453 ! Langerhans cell [Term] id: CL:0001016 name: immature CD1a-positive Langerhans cell namespace: cell def: "Immature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-low, CD86-low, and MHCII-low." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000028)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001014 ! CD1a-positive Langerhans cell [Term] id: CL:0001017 name: mature CD1a-positive Langerhans cell namespace: cell def: "Mature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [] comment: Originally described in the dendritic cell ontology (DC_CL:0000029)(PMID:19243617). When activated, these cells produce IL-6, IL-8, and IL-15. is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001014 ! CD1a-positive Langerhans cell [Term] id: CL:0001018 name: immature CD8_alpha-low Langerhans cell namespace: cell def: "Immature CD8_alpha-low Langerhans cell is a CD8_alpha-low Langerhans cell that is CD80-low, CD86-low, and MHCII-low." [] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000030)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001015 ! CD8_alpha-low Langerhans cell [Term] id: CL:0001020 name: mature CD8_alpha-low Langerhans cell namespace: cell def: "Mature CD8_alpha-low Langerhans cell is a CD8_alpha-low Langerhans cell that that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000031)(PMID:19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001015 ! CD8_alpha-low Langerhans cell [Term] id: CL:0001022 name: CD115-positive monocyte namespace: cell def: "CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive." [] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000033)(PMID:19243617). is_a: CL:0000576 ! monocyte [Term] id: CL:0001041 name: CD8-positive, CXCR3-positive, alpha-beta regulatory T cell namespace: cell def: "A CD8-positive alpha-beta-positive T cell with the phenotype CXCR3-positive and having suppressor function. They are capable of producing IL-10, suppressing proliferation, and suppressing IFN-gamma production." [] comment: These cells may be the human equivalent of murine CD8-positive, CD122-positive alpha-beta regulatory T cell. They are also found in the CD45RA-negative and CD62L-positive fraction. synonym: "CD8+CXCR3+ T cell" EXACT [] synonym: "CD8+CXCR3+ T lymphocyte" EXACT [] synonym: "CD8+CXCR3+ T(reg)" EXACT [] synonym: "CD8+CXCR3+ T-cell" EXACT [] synonym: "CD8+CXCR3+ Treg" EXACT [] synonym: "CD8-positive, CXCR3-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD8-positive, CXCR3-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD8-positive, CXCR3-positive, alpha-beta regulatory T-lymphocyte" EXACT [] synonym: "CD8-positive, CXCR3-positive, T(reg)" EXACT [] synonym: "CD8-positive, CXCR3-positive, Treg" EXACT [] is_a: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell [Term] id: CL:0001042 name: T-helper 22 cell namespace: cell def: "CD4-positive, alpha-beta T cell that produces IL-22." [] comment: TH22 cells are also reportedly CCR4-positive, CCR6-positive, CCR10-positive, CXCR3-negative. TH22 cells are reportedly capable of secreting IL-13. synonym: "helper T cell type 22" EXACT [] synonym: "T(H)-22 cell" EXACT [] synonym: "Th22 cell" EXACT [] synonym: "Th22 T cell" EXACT [] synonym: "Th22 T lymphocyte" EXACT [] synonym: "Th22 T-cell" EXACT [] synonym: "Th22 T-lymphocyte" EXACT [] is_a: CL:0000492 ! CD4-positive helper T cell [Term] id: CL:0001043 name: activated CD4-positive, alpha-beta T cell, human namespace: cell def: "A recently activated CD4-positive, alpha-beta T cell with the phenotype HLA-DRA-positive, CD38-positive, CD69-positive, CD62L-negative, CD127-negative, and CD25-positive." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'activated CD4+ T cell', but includes via logical inference from its parent additional markers known to be expressed on activated CD4+ T cells. The inclusion of HLA-DRA in the definition restricts this definition to human activated CD4+ T cells, as activated mouse T cells do not express MHC class II. synonym: "activated CD4+ T cell" BROAD [] synonym: "activated CD4-positive, alpha-beta T lymphocyte, human" EXACT [] synonym: "activated CD4-positive, alpha-beta T-cell, human" EXACT [] synonym: "activated CD4-positive, alpha-beta T-lymphocyte, human" EXACT [] is_a: CL:0000896 ! activated CD4-positive, alpha-beta T cell [Term] id: CL:0001044 name: effector CD4-positive, alpha-beta T cell namespace: cell def: "A CD4-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'effector CD4+ T cell'. The functional characteristics of this cell type currently undefined in CL, which affects its proper placement within the hierarchy. synonym: "effector CD4+ T cell" BROAD [] synonym: "effector CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "effector CD4-positive, alpha-beta T-cell" EXACT [] synonym: "effector CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell is_a: CL:0000911 ! effector T cell [Term] id: CL:0001045 name: naive CCR4-positive regulatory T cell namespace: cell def: "A naive regulatory T cell with the phenotype CD4-positive, CD25-positive, CD127lo, CCR4-positive, and CD45RO-negative." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'naive CCR4+ Treg'. The definition is valid for human; its applicability for mouse and other species is unknown. synonym: "naive CCR4+ Treg" EXACT [] synonym: "naive CCR4-positive regulatory T lymphocyte" EXACT [] synonym: "naive CCR4-positive regulatory T-cell" EXACT [] synonym: "naive CCR4-positive regulatory T-lymphocyte" EXACT [] is_a: CL:0001047 ! CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell is_a: CL:0002677 ! naive regulatory T cell [Term] id: CL:0001046 name: memory CCR4-positive regulatory T cell namespace: cell def: "A memory regulatory T cell with phenotype CD4-positive, CD25-positive, CD127lo, CCR4-positive, and CD45RO-positive." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'memory CCR4+ Treg'. The definition is valid for human; its applicability for mouse and other species is unknown. synonym: "memory CCR4+ Treg" EXACT [] synonym: "memory CCR4-positive regulatory T lymphocyte" EXACT [] synonym: "memory CCR4-positive regulatory T-cell" EXACT [] synonym: "memory CCR4-positive regulatory T-lymphocyte" EXACT [] is_a: CL:0001047 ! CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell is_a: CL:0002678 ! memory regulatory T cell [Term] id: CL:0001047 name: CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell namespace: cell def: "A CD4-positive, CD25-positive, alpha-beta regulatory T cell with the additional phenotype CCR4-positive." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'CCR4+ Treg'. The definition is valid for human; its applicability for mouse and other species is unknown. synonym: "CCR+ Treg" EXACT [] synonym: "CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-lymphocyte" EXACT [] is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell [Term] id: CL:0001048 name: activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell, human namespace: cell def: "A CD4-positive, CD25-positive, CCR4-positive, alpha-beta T regulatory cell with the phenotype HLA-DRA-positive, indicating recent activation." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'activated CCR4+ Treg'. The inclusion of HLA-DRA in the definition restricts this definition to human activated CD4+ T cells, as activated mouse T cells do not express MHC class II. synonym: "activated CCR4+ Treg" EXACT [] synonym: "activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-lymphocyte" EXACT [] is_a: CL:0001047 ! CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell [Term] id: CL:0001049 name: activated CD8-positive, alpha-beta T cell, human namespace: cell def: "A recently activated CD8-positive, alpha-beta T cell with the phenotype HLA-DRA-positive, CD38-positive, CD69-positive, CD62L-negative, CD127-negative, CCR7-negative, and CD25-positive." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'activated CD8+ T cell', but includes via logical inference from its parent additional markers known to be expressed on activated CD8+ T cells. The inclusion of HLA-DRA in the definition restricts this definition to human activated CD8+ T cells, as activated mouse T cells do not express MHC class II. synonym: "activated CD8+ T cell" BROAD [] synonym: "activated CD8-positive, alpha-beta T lymphocyte, human" EXACT [] synonym: "activated CD8-positive, alpha-beta T-cell, human" EXACT [] synonym: "activated CD8-positive, alpha-beta T-lymphocyte, human" EXACT [] is_a: CL:0000906 ! activated CD8-positive, alpha-beta T cell [Term] id: CL:0001050 name: effector CD8-positive, alpha-beta T cell namespace: cell def: "A CD8-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'effector CD8+ T cell'. The functional characteristics of this cell type currently undefined in CL, which affects its proper placement within the hierarchy. synonym: "effector CD8+ T cell" BROAD [] synonym: "effector CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "effector CD8-positive, alpha-beta T-cell" EXACT [] synonym: "effector CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell is_a: CL:0000911 ! effector T cell [Term] id: CL:0001051 name: CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell namespace: cell def: "A CD4-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'non-Th1/Th17 CD4+ T cell'. Cells of this phenotype may include T-helper 2 T cells and some naive CD4+ T cells. synonym: "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T lymphocyte" EXACT [] synonym: "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T-cell" EXACT [] synonym: "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T-lymphocyte" EXACT [] synonym: "non-Th1/Th17 CD4+ T cell" BROAD [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell [Term] id: CL:0001052 name: CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell namespace: cell def: "A CD8-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'non-Tc1/Tc17 CD8+ T cell'. Cells of this phenotype may include Tc2 T cells and some naive CD8+ T cells. synonym: "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T lymphocyte" EXACT [] synonym: "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T-cell" EXACT [] synonym: "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T-lymphocyte" EXACT [] synonym: "non-Tc1/Tc17 CD8+ T cell" BROAD [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell [Term] id: CL:0001053 name: IgD-negative memory B cell namespace: cell def: "A memory B cell that lacks expression of surface IgD." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'IgD- memory B cell'. The majority of these cells are class-switched, though some are IgM-positive. synonym: "IgD- memory B cell" EXACT [] is_a: CL:0000787 ! memory B cell [Term] id: CL:0001054 name: CD14-positive monocyte namespace: cell def: "A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'monocyte'. Note that while CD14 is considered a reliable marker for human monocytes, it is only expressed on approximately 85% of mouse monocytes. synonym: "monocyte" NARROW [] is_a: CL:0000576 ! monocyte [Term] id: CL:0001055 name: CD14-positive, CD16-low monocyte namespace: cell def: "An intermediate monocyte that is CD14-positive and with low amounts of CD16." [] comment: Definition is valid for human intermediate monocytes. synonym: "intermediate monocyte, human" EXACT [] is_a: CL:0002393 ! intermediate monocyte is_a: CL:0002397 ! CD14-positive, CD16-positive monocyte [Term] id: CL:0001056 name: dendritic cell, human namespace: cell def: "A dendritic cell with the phenotype HLA-DRA-positive." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'dendritic cell'. The inclusion of HLA-DRA in the definition restricts this definition to human dendritic cells. synonym: "dendritic cell" BROAD [] is_a: CL:0000451 ! dendritic cell [Term] id: CL:0001057 name: myeloid dendritic cell, human namespace: cell def: "A myeloid dendritic cell with the phenotype HLA-DRA-positive." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'myeloid dendritic cell'. The inclusion of HLA-DRA in the definition restricts this definition to human myeloid dendritic cells. synonym: "myeloid dendritic cell" BROAD [] is_a: CL:0000782 ! myeloid dendritic cell is_a: CL:0001056 ! dendritic cell, human [Term] id: CL:0001058 name: plasmacytoid dendritic cell, human namespace: cell def: "A plasmacytoid dendritic cell with the phenotype HLA-DRA-positive, CD123-positive, and CD11c-negative." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'plasmacytoid dendritic cell'. The inclusion of HLA-DRA in the definition restricts this definition to human plasmacytoid dendritic cells. synonym: "plasmacytoid dendritic cell" BROAD [] is_a: CL:0000784 ! plasmacytoid dendritic cell is_a: CL:0001056 ! dendritic cell, human [Term] id: CL:0001062 name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated namespace: cell def: "A CD8-positive, alpha beta memory T cell with the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative." [] comment: This cell type is seen in human but not found in the mouse. synonym: "CD8+ TEMRA" EXACT [] synonym: "CD8-positive TEMRA" EXACT [] synonym: "TEMRA" BROAD [] is_a: CL:0000909 ! CD8-positive, alpha-beta memory T cell [Term] id: CL:0001065 name: innate lymphoid cell namespace: cell def: "A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses." [] is_a: CL:0000542 ! lymphocyte property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0001-9990-8331 property_value: http://purl.org/dc/elements/1.1/date 2017-01-30T20:20:48Z xsd:dateTime [Term] id: CL:0001067 name: group 1 innate lymphoid cell namespace: cell def: "An innate lymphoid cell that is capable of producing the type 1 cytokine IFN-gamma, but not Th2 or Th17 cell-associated cytokines." [] is_a: CL:0001065 ! innate lymphoid cell property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0001-9990-8331 property_value: http://purl.org/dc/elements/1.1/date 2017-01-30T20:42:44Z xsd:dateTime [Term] id: CL:0001068 name: ILC1 namespace: cell def: "A group 1 innate lymphoid cell that is non-cytotoxic." [] is_a: CL:0001067 ! group 1 innate lymphoid cell property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0001-9990-8331 property_value: http://purl.org/dc/elements/1.1/date 2017-01-30T20:54:12Z xsd:dateTime [Term] id: CL:0001069 name: group 2 innate lymphoid cell namespace: cell def: "An innate lymphoid cell that is capable of producing T-helper 2-cell associated cytokines upon stimulation." [] synonym: "ILC2" EXACT [] synonym: "natural helper cell" EXACT [] synonym: "nuocyte" EXACT [] is_a: CL:0001065 ! innate lymphoid cell property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0001-9990-8331 property_value: http://purl.org/dc/elements/1.1/date 2017-01-30T21:20:08Z xsd:dateTime [Term] id: CL:0001071 name: group 3 innate lymphoid cell namespace: cell def: "An innate lymphoid cell that constituitively expresses RORgt and is capable of expressing IL17A and/or IL-22." [] synonym: "ILC3" EXACT [] is_a: CL:0001065 ! innate lymphoid cell property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0001-9990-8331 property_value: http://purl.org/dc/elements/1.1/date 2017-01-31T20:21:26Z xsd:dateTime [Term] id: CL:0001072 name: CD34-negative, CD117-positive innate lymphoid cell, human def: "An innate lymphoid cell in the human with the phenotype CD34-negative, CD117-positive, and a precusor to NK cells, ILC2 cells, and ILC3 cells." [] synonym: "CD34-negative, CD117-positive ILC" EXACT [] synonym: "CD34-negative, CD117-positive ILCP" EXACT [] synonym: "CD34-negative, CD117-positive innate lymphoid cell precusor" EXACT [] is_a: CL:0001082 ! immature innate lymphoid cell [Term] id: CL:0001073 name: CD34-negative, CD56-positive, CD117-positive innate lymphoid cell, human def: "An innate lymphoid cell in the human with the phenotype CD34-negative, CD56-positive, CD117-positive.Thie cell type may include precusors to NK cells and ILC3 cells." [] synonym: "CD34-negative, CD56-positive, CD117-positive ILC" EXACT [] synonym: "CD34-negative, CD56-positive, CD117-positive ILCP" EXACT [] synonym: "CD34-negative, CD56-positive, CD117-positive innate lymphoid cell precursor" EXACT [] is_a: CL:0001072 ! CD34-negative, CD117-positive innate lymphoid cell, human [Term] id: CL:0001074 name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human def: "An innate lymphoid cell precursor in the human with the phenotype CD34-positive, CD56-positive, CD117-positive.Thie cell type may include precusors to NK cells and ILC3 cells." [] synonym: "CD34-positive, CD56-positive, CD117-positive CILP" EXACT [] is_a: CL:0001082 ! immature innate lymphoid cell [Term] id: CL:0001075 name: KLRG1-positive innate lymphoid cell, human def: "An innate lymphoid cell in the human with the phenotype KLRG1-positive that is a precusor for ILC2 cells." [] synonym: "KLRG1-positive ILC" EXACT [] is_a: CL:0001072 ! CD34-negative, CD117-positive innate lymphoid cell, human [Term] id: CL:0001076 name: NKp46-positive innate lymphoid cell, human def: "An innate lymphoid cell in the human with the phenotype NKp46-positive that is a precusor for NK cells and ILC3 cells." [] synonym: "NKp46-positive ILC" EXACT [] is_a: CL:0001074 ! CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human [Term] id: CL:0001077 name: ILC1, human def: "An ILC1 cell in the human with the phenotype CD56-negative, IL-7Ralpha-positive, T-bet-positive." [] synonym: "innate lymphoid cell 1, human" EXACT [] is_a: CL:0001068 ! ILC1 [Term] id: CL:0001078 name: group 3 innate lymphoid cell, human def: "A group 3 innate lymphoid cell in the human with the phenotype IL-7Ralpha-positive." [] synonym: "ILC3, human" EXACT [] is_a: CL:0001071 ! group 3 innate lymphoid cell [Term] id: CL:0001079 name: NKp44-positive group 3 innate lymphoid cell, human def: "A group 3 innate lymphoid cell in the human with the phenotype IL-7Ralpha-positive, and NKp44-positive." [] is_a: CL:0001078 ! group 3 innate lymphoid cell, human [Term] id: CL:0001080 name: NKp44-negative group 3 innate lymphoid cell, human def: "A group 3 innate lymphoid cell in the human with the phenotype IL-7Ralpha-positive, and NKp44-negative." [] is_a: CL:0001078 ! group 3 innate lymphoid cell, human [Term] id: CL:0001081 name: group 2 innate lymphoid cell, human def: "A group 2 innate lymphoid cell in the human with the phenotype CD25-positive, CD127-positive, CD161-positive, and GATA-3-positive." [] synonym: "ILC2, human" EXACT [] is_a: CL:0001069 ! group 2 innate lymphoid cell [Term] id: CL:0001082 name: immature innate lymphoid cell def: "An innate lyphoid cell with an immature phenotype." [] synonym: "immature ILC" EXACT [] is_a: CL:0001065 ! innate lymphoid cell [Term] id: CL:0001087 name: effector memory CD4-positive, alpha-beta T cell, terminally differentiated namespace: cell def: "A CD4-positive, alpha beta memory T cell with the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative." [] comment: This cell type is seen in human but not found in the mouse. synonym: "CD4+ TEMRA" EXACT [] synonym: "CD4-positive TEMRA" EXACT [] synonym: "TEMRA" BROAD [] is_a: CL:0000897 ! CD4-positive, alpha-beta memory T cell property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0001-9990-8331 property_value: http://purl.org/dc/elements/1.1/date 2021-01-18T16:32:44Z xsd:dateTime [Term] id: CL:0001200 name: lymphocyte of B lineage, CD19-positive namespace: cell def: "A lymphocyte of B lineage that is CD19-positive." [] comment: Types of B lineage lymphocytes include B cells and antibody secreting cells (plasmablasts and plasma cells). Lymphocytes of B cell lineage can be distinguished from those of T cell lineage by their lack of CD3e (as part of the T cell receptor complex). is_a: CL:0000945 ! lymphocyte of B lineage property_value: http://purl.org/dc/elements/1.1/creator https://orcid.org/0000-0001-9990-8331 xsd:string [Term] id: CL:0001201 name: B cell, CD19-positive namespace: cell def: "A B cell that is CD19-positive." [] synonym: "B lymphocyte, CD19-positive" EXACT [] synonym: "B-cell, CD19-positive" EXACT [] synonym: "B-lymphocyte, CD19-positive" EXACT [] synonym: "CD19+ B cell" EXACT [] synonym: "CD19-positive B cell" EXACT [] is_a: CL:0000236 ! B cell is_a: CL:0001200 ! lymphocyte of B lineage, CD19-positive property_value: http://purl.org/dc/elements/1.1/creator https://orcid.org/0000-0001-9990-8331 xsd:string [Term] id: CL:0001202 name: CD86-positive plasmablast namespace: cell def: "A plasmablast that is CD86-positive." [] synonym: "CD86+ plasmablast" EXACT [] synonym: "CD86-positive, CD20-negative plasmablast" BROAD [] is_a: CL:0000980 ! plasmablast property_value: http://purl.org/dc/elements/1.1/creator https://orcid.org/0000-0001-9990-8331 xsd:string [Term] id: CL:0001203 name: CD8-positive, alpha-beta memory T cell, CD45RO-positive namespace: cell def: "A CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." [] synonym: "CD8-positive, alpha-beta memory T lymphocyte, CD45RO-positive" EXACT [] synonym: "CD8-positive, alpha-beta memory T-cell, CD45RO-positive" EXACT [] synonym: "CD8-positive, alpha-beta memory T-lymphocyte, CD45RO-positive" EXACT [] is_a: CL:0000909 ! CD8-positive, alpha-beta memory T cell [Term] id: CL:0001204 name: CD4-positive, alpha-beta memory T cell, CD45RO-positive namespace: cell def: "CD4-positive, alpha-beta long-lived T cell with the phenotype CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." [] synonym: "CD4-positive, alpha-beta memory T lymphocyte, CD45RO-positive" EXACT [] synonym: "CD4-positive, alpha-beta memory T-cell, CD45RO-positive" EXACT [] synonym: "CD4-positive, alpha-beta memory T-lymphocyte, CD45RO-positive" EXACT [] is_a: CL:0000897 ! CD4-positive, alpha-beta memory T cell [Term] id: CL:0002001 name: CD34-positive, CD38-positive granulocyte monocyte progenitor namespace: cell def: "A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative." [] comment: Markers are for human cells. According to different research groups, CD45RA is present or absent on this cell population. is_a: CL:0000557 ! granulocyte monocyte progenitor cell created_by: tmeehan creation_date: 2010-01-13T03:19:22Z [Term] id: CL:0002002 name: Kit-positive granulocyte monocyte progenitor namespace: cell def: "A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative." [] comment: Markers are found on mouse cells. is_a: CL:0000557 ! granulocyte monocyte progenitor cell created_by: tmeehan creation_date: 2010-01-13T03:19:28Z [Term] id: CL:0002026 name: CD34-negative, CD41-positive, CD42-positive megakaryocyte cell namespace: cell def: "A megakaryocyte progenitor cell that is CD34-negative, CD41-positive and CD42-positive." [] comment: Markers are commonly associated with human cells. is_a: CL:0000556 ! megakaryocyte created_by: tmeehan creation_date: 2010-04-26T03:59:22Z [Term] id: CL:0002027 name: CD9-positive, CD41-positive megakaryocyte cell namespace: cell def: "A megakaryocyte cell with is CD9-positive and CD41-positive." [] comment: Markers are commonly associated with mouse cells. is_a: CL:0000556 ! megakaryocyte created_by: tmeehan creation_date: 2010-04-27T10:39:07Z [Term] id: CL:0002037 name: CD2-positive, CD5-positive, CD44-positive alpha-beta intraepithelial T cell namespace: cell def: "Intraepithelial T cells with a memory phenotype of CD2-positive, CD5-positive, and CD44-positive." [] synonym: "memory alpha beta IEL" EXACT [] is_a: CL:0000793 ! CD4-positive, alpha-beta intraepithelial T cell created_by: tmeehan creation_date: 2009-10-20T02:20:43Z [Term] id: CL:0002038 name: T follicular helper cell namespace: cell def: "A CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that expresses is BCL6-high, ICOS-high and PD1-high, and stimulates follicular B cells to undergo class-switching and antibody production." [] synonym: "follicular B helper T cell" RELATED [] synonym: "follicular helper T cell" RELATED [] synonym: "follicular helper T-cell" RELATED [] synonym: "follicular T cell" RELATED [] synonym: "follicular T-cell" RELATED [] synonym: "follicular T-helper cell" RELATED [] synonym: "T(FH)" EXACT [] synonym: "Tfh" EXACT [] is_a: CL:0000492 ! CD4-positive helper T cell created_by: tmeehan creation_date: 2009-10-29T04:01:27Z [Term] id: CL:0002039 name: immature NK T cell stage I namespace: cell def: "A CD24-high, CD4-low, CD8-low, CD44-negative, NK1.1-negative NK T cell." [] is_a: CL:0000914 ! immature NK T cell created_by: tmeehan creation_date: 2009-10-29T04:09:16Z [Term] id: CL:0002040 name: immature NK T cell stage II namespace: cell def: "A CD24-low, CD44-negative, NK1.1-negative NK T cell." [] comment: NKT.44-NK1.1-.Th was assigned as an exact synonym based on sorting strategy displayed at immgene.org. synonym: "NKT.44-NK1.1-.Th" EXACT [] is_a: CL:0000914 ! immature NK T cell created_by: tmeehan creation_date: 2009-10-29T04:13:43Z [Term] id: CL:0002041 name: immature NK T cell stage III namespace: cell def: "A CD24-low, CD44-positive, DX5-low, NK1.1-negative NK T cell." [] synonym: "NKT.44+.NK1.1-.Th" BROAD [] is_a: CL:0000914 ! immature NK T cell created_by: tmeehan creation_date: 2009-10-29T04:14:48Z [Term] id: CL:0002042 name: immature NK T cell stage IV namespace: cell def: "A CD24-low, CD44-positive, DX5-high, NK1.1-negative NK T cell." [] synonym: "NKT.44+.NK1.1-.Th" BROAD [] is_a: CL:0000914 ! immature NK T cell created_by: tmeehan creation_date: 2009-10-29T04:17:38Z [Term] id: CL:0002047 name: Fraction B precursor B cell namespace: cell def: "A precursor B cell that is CD45RA-positive, CD43-positive, CD24-positive and BP-1-negative." [] comment: Markers are commonly associated with mouse cells. These cells are also reportedly RAG1-positive and RAG2-positive. synonym: "Fr. B" EXACT [] synonym: "Fraction B" EXACT [] is_a: CL:0002400 ! Fraction B/C precursor B cell created_by: tmeehan creation_date: 2010-04-28T11:56:21Z [Term] id: CL:0002048 name: late pro-B cell namespace: cell def: "A pre-B cell precursor is CD19-low, CD22-positive , CD34-positive, CD38-positive." [] comment: Late pro-B cells are also reportedly CD10-positive, CD20-negative, CD21-negative, and TdT-positive. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. is_a: CL:0000817 ! precursor B cell created_by: tmeehan creation_date: 2010-04-28T12:06:06Z [Term] id: CL:0002049 name: Fraction C precursor B cell namespace: cell def: "A precursor B cell is CD45R-positive, CD43-positive, CD24-positive, and BP-positive. Intracellularly expression of surrogate light chain, Rag1 and Rag2, TdT, occurs while there is no expression of mu heavy chain." [] synonym: "Fraction C" RELATED [] is_a: CL:0002400 ! Fraction B/C precursor B cell created_by: tmeehan creation_date: 2010-04-28T02:04:01Z [Term] id: CL:0002050 name: Fraction C' precursor B cell namespace: cell def: "A pre-BCR-positive precursor B cell that is CD24-high, CD25-positive, CD43-positive, CD45R-positive and BP-positive." [] synonym: "Fr. C'" EXACT [] synonym: "Fraction C-prime" EXACT [] is_a: CL:0000817 ! precursor B cell created_by: tmeehan creation_date: 2010-04-28T02:13:46Z [Term] id: CL:0002051 name: CD38-high pre-BCR positive cell namespace: cell def: "A pre-BCR positive B cell that is CD38-high." [] comment: Markers are associated with human cells. synonym: "large pre-B cell type I" RELATED [] is_a: CL:0000952 ! preBCR-positive large pre-B-II cell created_by: tmeehan creation_date: 2010-04-28T02:27:47Z [Term] id: CL:0002052 name: Fraction D precursor B cell namespace: cell def: "A pre-B cell that is pre-BCR-negative, and the kappa- and lambda- light immunoglobulin light chain-negative, CD43-low, and is BP-1-positive, CD45R-positive and CD25-positive. This cell type is also described as being AA4-positive, IgM-negative, CD19-positive, CD43-low/negative, and HSA-positive." [] comment: Fraction D precursor B cells are also reportedly CD24-positive and sIgD-negative. synonym: "Fr. D" EXACT [] synonym: "Fraction D pre-B cell" EXACT [] is_a: CL:0002400 ! Fraction B/C precursor B cell created_by: tmeehan creation_date: 2010-04-28T02:55:16Z [Term] id: CL:0002053 name: CD22-positive, CD38-low small pre-B cell namespace: cell def: "A small pre-B cell that is CD22-positive and CD38-low." [] comment: Markers are associated with human cell. RAG expression maybe diminishing. synonym: "small pre-B cell" EXACT [] is_a: CL:0000954 ! small pre-B-II cell created_by: tmeehan creation_date: 2010-04-28T03:04:48Z [Term] id: CL:0002054 name: Fraction E immature B cell namespace: cell def: "An immature B cell that is IgM-positive, CD45R-positive, CD43-low, CD25-negative, and CD127-negative. This cell type has also been described as being AA4-positive, IgM-positive, CD19-positive, CD43-low/negative, and HSA-positive." [] comment: Markers associated with mouse cells. These cells are also reportedly sIgD-negative. is_a: CL:0000816 ! immature B cell created_by: tmeehan creation_date: 2010-04-28T03:13:47Z [Term] id: CL:0002055 name: CD38-negative immature B cell namespace: cell def: "An immature B cell that is CD38-negative, CD10-low, CD21-low, and CD22-high." [] comment: Markers are associated with human cell type. is_a: CL:0000816 ! immature B cell created_by: tmeehan creation_date: 2010-04-28T03:19:14Z [Term] id: CL:0002056 name: Fraction F mature B cell namespace: cell def: "A mature B cell subset originally defined as having being CD45R-positive, IgM-positive, IgD-positive and CD43-negative. Subsequent research demonstrated being CD21-positive and CD23-negative and CD93 negative." [] is_a: CL:0000822 ! B-2 B cell created_by: tmeehan creation_date: 2010-04-30T03:01:48Z [Term] id: CL:0002057 name: CD14-positive, CD16-negative classical monocyte namespace: cell def: "A classical monocyte that is CD14-positive, CD16-negative, CD64-positive, CD163-positive." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16- monocyte'. The markers used in the definition are associated with human monocytes. synonym: "CD16- monocyte" EXACT [] synonym: "CD16-negative monocyte" EXACT [] is_a: CL:0000860 ! classical monocyte is_a: CL:0001054 ! CD14-positive monocyte created_by: tmeehan creation_date: 2010-06-05T08:25:41Z [Term] id: CL:0002058 name: Gr1-low non-classical monocyte namespace: cell def: "A resident monocyte that is Gr-1 low, CD43-positive, and CX3CR1-positive." [] comment: Markers are associated with mice. The Gr epitope is used to describe this cell type is found on both Ly6c and Ly6g. However, its the Ly6c that is considered the specific marker, and thus used in the cross-product. Also, this cell-type is sometimes described as being Gr1-negative. is_a: CL:0000875 ! non-classical monocyte is_a: CL:0002398 ! Gr1-positive, CD43-positive monocyte created_by: tmeehan creation_date: 2010-06-05T08:25:44Z [Term] id: CL:0002059 name: CD8alpha-positive thymic conventional dendritic cell namespace: cell def: "A conventional thymic dendritic cell that is CD8alpha-positive." [] synonym: "CD8alpha-alpha-positive thymic conventional dendritic cell" EXACT [] synonym: "DC.8+.Th" EXACT [] is_a: CL:0000941 ! thymic conventional dendritic cell created_by: tmeehan creation_date: 2010-06-07T02:48:36Z [Term] id: CL:0002060 name: melanophage namespace: cell def: "A melanin-containing macrophage that obtains the pigment by phagocytosis of melanosomes." [] is_a: CL:0000864 ! tissue-resident macrophage created_by: tmeehan creation_date: 2010-06-22T10:46:12Z [Term] id: CL:0002061 name: T-helper 9 cell namespace: cell def: "A T-helper cell that is characterized by secreting interleukin 9 and responding to helminth infections. This cell-type can derives from Th2 cells in the presence of TGF-beta and IL-4. Th2 cytokine production is surpressed." [] synonym: "T helper cells type 9" EXACT [] synonym: "T(H)-9 cell" EXACT [] synonym: "Th9" EXACT [] is_a: CL:0000492 ! CD4-positive helper T cell created_by: tmeehan creation_date: 2010-06-22T11:18:44Z [Term] id: CL:0002087 name: nongranular leukocyte namespace: cell def: "A leukocyte that lacks granules." [] synonym: "agranular leukocyte" EXACT [] xref: FMA:62855 is_a: CL:0000738 ! leukocyte created_by: tmeehan creation_date: 2010-07-22T11:30:33Z [Term] id: CL:0002089 name: group 2 innate lymphoid cell, mouse namespace: cell def: "A group 2 innate lymphoid cell in the mouse capable of secreting IL-13 in response to a helminth infection. This cell is lineage-negative, ICOS-positive, IL1RL1-positive, IL7Ralpha-positive, and IL17Br-positive." [] synonym: "nuocyte" BROAD [] is_a: CL:0001069 ! group 2 innate lymphoid cell created_by: tmeehan creation_date: 2010-08-12T02:22:19Z [Term] id: CL:0002092 name: bone marrow cell namespace: cell def: "A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells." [] comment: MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense. xref: BTO:0004850 xref: FMA:83621 relationship: part_of UBERON:0002371 ! bone marrow created_by: tmeehan creation_date: 2010-07-22T04:48:15Z [Term] id: CL:0002101 name: CD38-positive naive B cell namespace: cell def: "A CD38-positive naive B cell is a mature B cell that has the phenotype CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." [] synonym: "CD38+ naive B cell" EXACT [] synonym: "CD38+ naive B lymphocyte" EXACT [] synonym: "CD38+ naive B-cell" EXACT [] synonym: "CD38+ naive B-lymphocyte" EXACT [] synonym: "CD38-positive naive B lymphocyte" EXACT [] synonym: "CD38-positive naive B-cell" EXACT [] synonym: "CD38-positive naive B-lymphocyte" EXACT [] is_a: CL:0000788 ! naive B cell [Term] id: CL:0002102 name: CD38-negative naive B cell namespace: cell def: "A CD38-negative naive B cell is a mature B cell that has the phenotype CD38-negative, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." [] synonym: "CD38- naive B cell" EXACT [] synonym: "CD38- naive B lymphocyte" EXACT [] synonym: "CD38- naive B-cell" EXACT [] synonym: "CD38- naive B-lymphocyte" EXACT [] synonym: "CD38-negative naive B lymphocyte" EXACT [] synonym: "CD38-negative naive B-cell" EXACT [] synonym: "CD38-negative naive B-lymphocyte" EXACT [] is_a: CL:0000788 ! naive B cell [Term] id: CL:0002103 name: IgG-positive double negative memory B cell namespace: cell def: "An IgG-positive double negative memory B cell is a double negative memory B cell with the phenotype IgG-positive, IgD-negative, and CD27-negative." [] synonym: "IgG+ dn memory B cell" EXACT [] synonym: "IgG+ dn memory B lymphocyte" EXACT [] synonym: "IgG+ dn memory B-cell" EXACT [] synonym: "IgG+ dn memory B-lymphocyte" EXACT [] synonym: "IgG+ double negative memory B cell" EXACT [] synonym: "IgG+ double negative memory B lymphocyte" EXACT [] synonym: "IgG+ double negative memory B-cell" EXACT [] synonym: "IgG+ double negative memory B-lymphocyte" EXACT [] synonym: "IgG-positive dn memory B cell" EXACT [] synonym: "IgG-positive dn memory B lymphocyte" EXACT [] synonym: "IgG-positive dn memory B-cell" EXACT [] synonym: "IgG-positive dn memory B-lymphocyte" EXACT [] synonym: "IgG-positive double negative memory B lymphocyte" EXACT [] synonym: "IgG-positive double negative memory B-cell" EXACT [] synonym: "IgG-positive double negative memory B-lymphocyte" EXACT [] is_a: CL:0000981 ! double negative memory B cell [Term] id: CL:0002104 name: IgG-negative double negative memory B cell namespace: cell def: "An IgG-negative double negative memory B cell is a double negative memory B cell with the phenotype IgG-negative, IgD-negative, and CD27-negative." [] synonym: "IgG- dn memory B cell" EXACT [] synonym: "IgG- dn memory B lymphocyte" EXACT [] synonym: "IgG- dn memory B-cell" EXACT [] synonym: "IgG- dn memory B-lymphocyte" EXACT [] synonym: "IgG- double negative memory B cell" EXACT [] synonym: "IgG- double negative memory B lymphocyte" EXACT [] synonym: "IgG- double negative memory B-cell" EXACT [] synonym: "IgG- double negative memory B-lymphocyte" EXACT [] synonym: "IgG-negative dn memory B cell" EXACT [] synonym: "IgG-negative dn memory B lymphocyte" EXACT [] synonym: "IgG-negative dn memory B-cell" EXACT [] synonym: "IgG-negative dn memory B-lymphocyte" EXACT [] synonym: "IgG-negative double negative memory B lymphocyte" EXACT [] synonym: "IgG-negative double negative memory B-cell" EXACT [] synonym: "IgG-negative double negative memory B-lymphocyte" EXACT [] is_a: CL:0000981 ! double negative memory B cell [Term] id: CL:0002105 name: CD38-positive IgG memory B cell namespace: cell def: "A CD38-positive IgG memory B cell is a class switched memory B cell that expresses IgG on the cell surface with the phenotype CD38-positive and IgG-positive." [] synonym: "CD38+ IgG memory B cell" EXACT [] synonym: "CD38+ IgG memory B lymphocyte" EXACT [] synonym: "CD38+ IgG memory B-cell" EXACT [] synonym: "CD38+ IgG memory B-lymphocyte" EXACT [] synonym: "CD38-positive IgG memory B lymphocyte" EXACT [] synonym: "CD38-positive IgG memory B-cell" EXACT [] synonym: "CD38-positive IgG memory B-lymphocyte" EXACT [] is_a: CL:0000979 ! IgG memory B cell [Term] id: CL:0002106 name: IgD-positive CD38-positive IgG memory B cell namespace: cell def: "An IgD-positive CD38-positive IgG memory B cell is a CD38-positive IgG-positive class switched memory B cell that has class switched and expresses IgD on the cell surface with the phenotype IgD-positive, CD38-positive, and IgG-positive." [] is_a: CL:0002105 ! CD38-positive IgG memory B cell [Term] id: CL:0002107 name: IgD-negative CD38-positive IgG memory B cell namespace: cell def: "An IgD-negative CD38-positive IgG memory B cell is a CD38-positive IgG-positive that has class switched and lacks expression of IgD on the cell surface with the phenotype IgD-negative, CD38-positive, and IgG-positive." [] is_a: CL:0001053 ! IgD-negative memory B cell is_a: CL:0002105 ! CD38-positive IgG memory B cell [Term] id: CL:0002108 name: CD38-negative IgG memory B cell namespace: cell def: "A CD38-negative IgG memory B cell is a IgG-positive class switched memory B cell that has class switched and expresses IgG on the cell surface with the phenotype CD38-negative, IgD-negative, and IgG-positive." [] is_a: CL:0000979 ! IgG memory B cell is_a: CL:0001053 ! IgD-negative memory B cell [Term] id: CL:0002109 name: B220-positive CD38-positive naive B cell namespace: cell def: "A B220-positive CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-positive, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." [] synonym: "B220+CD38+ naive B cell" EXACT [] synonym: "B220+CD38+ naive B lymphocyte" EXACT [] synonym: "B220+CD38+ naive B-cell" EXACT [] synonym: "B220+CD38+ naive B-lymphocyte" EXACT [] synonym: "B220-positive CD38-positive naive B lymphocyte" EXACT [] synonym: "B220-positive CD38-positive naive B-cell" EXACT [] synonym: "B220-positive CD38-positive naive B-lymphocyte" EXACT [] synonym: "CD38+B220+ naive B cell" EXACT [] synonym: "CD38+B220+ naive B lymphocyte" EXACT [] synonym: "CD38+B220+ naive B-cell" EXACT [] synonym: "CD38+B220+ naive B-lymphocyte" EXACT [] is_a: CL:0002101 ! CD38-positive naive B cell [Term] id: CL:0002110 name: B220-low CD38-positive naive B cell namespace: cell def: "A B220-low CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-low, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." [] is_a: CL:0002109 ! B220-positive CD38-positive naive B cell [Term] id: CL:0002111 name: CD38-negative unswitched memory B cell namespace: cell def: "An CD38-negative unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-negative, IgD-positive, CD138-negative, and IgG-negative." [] synonym: "CD38- unswitched memory B cell" EXACT [] synonym: "CD38- unswitched memory B lymphocyte" EXACT [] synonym: "CD38- unswitched memory B-cell" EXACT [] synonym: "CD38- unswitched memory B-lymphocyte" EXACT [] synonym: "CD38-negative unswitched memory B lymphocyte" EXACT [] synonym: "CD38-negative unswitched memory B-cell" EXACT [] synonym: "CD38-negative unswitched memory B-lymphocyte" EXACT [] is_a: CL:0000970 ! unswitched memory B cell [Term] id: CL:0002112 name: B220-positive CD38-negative unswitched memory B cell namespace: cell def: "A B220-positive CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-positive, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." [] is_a: CL:0002111 ! CD38-negative unswitched memory B cell [Term] id: CL:0002113 name: B220-low CD38-negative unswitched memory B cell namespace: cell def: "A B220-low CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-low, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." [] is_a: CL:0002112 ! B220-positive CD38-negative unswitched memory B cell [Term] id: CL:0002114 name: CD38-positive unswitched memory B cell namespace: cell def: "A CD38-positive unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-positive, IgD-positive, CD138-negative, and IgG-negative." [] synonym: "CD38+ unswitched memory B cell" EXACT [] synonym: "CD38+ unswitched memory B lymphocyte" EXACT [] synonym: "CD38+ unswitched memory B-cell" EXACT [] synonym: "CD38+ unswitched memory B-lymphocyte" EXACT [] synonym: "CD38-positive unswitched memory B lymphocyte" EXACT [] synonym: "CD38-positive unswitched memory B-cell" EXACT [] synonym: "CD38-positive unswitched memory B-lymphocyte" EXACT [] is_a: CL:0000970 ! unswitched memory B cell [Term] id: CL:0002115 name: B220-positive CD38-positive unswitched memory B cell namespace: cell def: "A B220-positive CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-positive, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." [] is_a: CL:0002114 ! CD38-positive unswitched memory B cell [Term] id: CL:0002116 name: B220-low CD38-positive unswitched memory B cell namespace: cell def: "A B220-low CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-low, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." [] is_a: CL:0002115 ! B220-positive CD38-positive unswitched memory B cell [Term] id: CL:0002117 name: IgG-negative class switched memory B cell namespace: cell def: "A class switched memory B cell that lacks IgG on the cell surface." [] synonym: "IgG- class switched memory B cell" EXACT [] synonym: "IgG- class switched memory B lymphocyte" EXACT [] synonym: "IgG- class switched memory B-cell" EXACT [] synonym: "IgG- class switched memory B-lymphocyte" EXACT [] synonym: "IgG-negative class switched memory B lymphocyte" EXACT [] synonym: "IgG-negative class switched memory B-cell" EXACT [] synonym: "IgG-negative class switched memory B-lymphocyte" EXACT [] is_a: CL:0000972 ! class switched memory B cell [Term] id: CL:0002118 name: CD38-negative IgG-negative class switched memory B cell namespace: cell def: "A CD38-negative IgG-negative memory B cell is a IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-negative and IgG-negative." [] is_a: CL:0002117 ! IgG-negative class switched memory B cell [Term] id: CL:0002119 name: CD38-positive IgG-negative class switched memory B cell namespace: cell def: "A CD38-positive IgG-negative memory B cell is an IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-positive and IgG-negative." [] is_a: CL:0002117 ! IgG-negative class switched memory B cell [Term] id: CL:0002120 name: CD24-positive CD38-negative IgG-negative class switched memory B cell namespace: cell def: "An CD24-positive CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-positive, CD38-negative, and IgG-negative." [] is_a: CL:0002118 ! CD38-negative IgG-negative class switched memory B cell [Term] id: CL:0002121 name: CD24-negative CD38-negative IgG-negative class switched memory B cell namespace: cell def: "A CD24-negative CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-negative, CD38-negative, and IgG-negative." [] is_a: CL:0002118 ! CD38-negative IgG-negative class switched memory B cell [Term] id: CL:0002122 name: B220-positive CD38-positive IgG-negative class switched memory B cell namespace: cell def: "A B220-positive CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-positive, CD38-positive, and IgG-negative." [] is_a: CL:0002119 ! CD38-positive IgG-negative class switched memory B cell [Term] id: CL:0002123 name: B220-low CD38-positive IgG-negative class switched memory B cell namespace: cell def: "A B220-low CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-low, CD38-positive, and IgG-positive." [] is_a: CL:0002122 ! B220-positive CD38-positive IgG-negative class switched memory B cell [Term] id: CL:0002124 name: CD27-positive gamma-delta T cell namespace: cell def: "A circulating gamma-delta T cell that is CD27-positive and capable of producing IFN-gamma." [] synonym: "gammadelta27-positive" EXACT [] synonym: "gd27-positive" EXACT [] is_a: CL:0000800 ! mature gamma-delta T cell created_by: tmeehan creation_date: 2010-08-18T09:57:19Z [Term] id: CL:0002125 name: CD27-negative gamma-delta T cell namespace: cell def: "A circulating gamma-delta T cell that expresses RORgamma(t), is CD27-negative and is capable of IL-17 secretion." [] synonym: "gammadelta-17 cells" EXACT [] is_a: CL:0000800 ! mature gamma-delta T cell created_by: tmeehan creation_date: 2010-08-18T09:57:29Z [Term] id: CL:0002126 name: CD25-positive, CD27-positive immature gamma-delta T cell namespace: cell def: "A CD25-positive, CD27-positive immature gamma-delta T cell found in the thymus that has an immature phenotype (i.e. CD24-high, CD25-high, CD62L-high, CD44-high, CD2-low, CD5-low)." [] is_a: CL:0000799 ! immature gamma-delta T cell is_a: CL:0000893 ! thymocyte created_by: tmeehan creation_date: 2010-08-18T10:35:37Z [Term] id: CL:0002127 name: innate effector T cell namespace: cell def: "A T cell with a receptor of limited diversity that is capable of immediate effector functions upon stimulation." [] is_a: CL:0000911 ! effector T cell created_by: tmeehan creation_date: 2010-08-20T02:14:25Z [Term] id: CL:0002128 name: Tc17 cell namespace: cell def: "A CD8-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-positive, CCR5-high, CD45RA-negative, and capable of producing IL-17 and some IFNg." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'Tc17 CD8+ T cell', but its logical definition includes additional known characteristics of Tc17 T cells. Found in the CD27-positive, CD28-positive or CD27-negative, CD28-positive fractions with the phenotype CCR4-negative and CCR7-negative (this sentence not part of definition). synonym: "CD8-positive Th17 cell" EXACT [] synonym: "Tc17 CD8+ T cell" EXACT [] synonym: "Tc17 T cell" EXACT [] synonym: "Tc17 T lymphocyte" EXACT [] synonym: "Tc17 T-cell" EXACT [] synonym: "Tc17 T-lymphocyte" EXACT [] synonym: "Th17 CD8-positive T cell" EXACT [] synonym: "Th17 non-TFH CD8-positive T cell" EXACT [] is_a: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell [Term] id: CL:0002138 name: endothelial cell of lymphatic vessel namespace: cell alt_id: CL:1000421 def: "A endothelial cell of a lymphatic vessel. The border of the oak leaf-shaped endothelial cell of initial lymphatics are joined by specialized buttons. The discontinuous feature of buttons distinguishes them from zippers in collecting lymphatics, but both types of junctions are composed of proteins typical of adherens junctions and tight junctions found in the endothelium of blood vessels. Buttons seal the sides of flaps of the oak leaf-shaped endothelial cell, leaving open the tips of flaps as routes for fluid entry without disassembly and reformation of intercellular junctions." [] synonym: "LEC" EXACT [] synonym: "lymphatic endothelial cell" EXACT [] xref: BTO:0004167 xref: FMA:68458 relationship: part_of UBERON:0001473 ! lymphatic vessel created_by: tmeehan creation_date: 2010-08-24T02:05:28Z [Term] id: CL:0002150 name: epithelioid macrophage namespace: cell def: "Epithelioid macrophage is an activated macrophage that resembles an epithelial cell with finely granular, pale eosinophilic cytoplasm and central, ovoid nucleus (oval or elongate). This cell type is able to merge into one another to form aggregates. The presence of such aggregates may characterize some pathologic conditions, mainly granulomatous inflammation." [] synonym: "epithelioid cell" BROAD [] synonym: "epithelioid histocyte" EXACT [] synonym: "epitheloid macrophage" EXACT [] xref: FMA:83514 is_a: CL:0000235 ! macrophage created_by: tmeehan creation_date: 2010-08-24T03:48:30Z [Term] id: CL:0002218 name: immature dendritic epithelial T cell precursor namespace: cell def: "A double negative thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18." [] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "immature DEC precursor" EXACT [] synonym: "immature DETC precursor" EXACT [] is_a: CL:0002404 ! fetal thymocyte created_by: tmeehan creation_date: 2010-10-07T01:58:00Z [Term] id: CL:0002240 name: marrow fibroblast namespace: cell def: "A fibroblast in the bone marrow." [] xref: FMA:84377 is_a: CL:0002092 ! bone marrow cell created_by: tmeehan creation_date: 2010-09-07T02:25:18Z [Term] id: CL:0002247 name: pleural macrophage namespace: cell def: "A tissue macrophage that is in the pleural space." [] xref: FMA:83024 is_a: CL:0000864 ! tissue-resident macrophage created_by: tmeehan creation_date: 2010-09-07T04:16:43Z [Term] id: CL:0002293 name: epithelial cell of thymus namespace: cell alt_id: CL:1000459 def: "An epithelial cell of the thymus. Epithelial reticular cells are pleomorphic, stellate, non-phagocytic cells which seem to be supportive in function and are held together by desmosomes. They replace the fibroblastoid reticular cells found in other lymphoid organs. Other epithelial cells in the medulla have the ultrastructure of secretory cells. Although different epithelial cells throughout the thymus appear alike by light microscopy their ultrastructure and function varies." [] synonym: "epithelial cell of thymus gland" EXACT [] synonym: "epithelial reticular cell" EXACT [] synonym: "epithelial reticular cell of thymus" EXACT [] synonym: "thymic epithelial cell" EXACT [] xref: CALOHA:TS-1040 xref: FMA:72208 relationship: part_of UBERON:0002370 ! thymus created_by: tmeehan creation_date: 2010-09-13T02:34:22Z [Term] id: CL:0002294 name: type-1 epithelial cell of thymus namespace: cell def: "An epithelial cell with a well defined Golgi apparatus that makes up the continuous layer of cells bordering the thymic tissue beneath the capsule." [] synonym: "subcapsular thymic epithelial cell" EXACT [] xref: FMA:72209 is_a: CL:0002364 ! cortical thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:23Z [Term] id: CL:0002295 name: type-6 epithelial cell of thymus namespace: cell def: "A thymic epithelial cell that has an eccentric, round, or irregularly shaped hetero or euchromatic nucleus. The hallmark of this cell type is the presence of vacuoles, which are clustered in one area of the cytoplasm in the vicinity of the nucleus. The vacuoles are small and acquire a grape-like form, occasionally showing delicate internal microvillous projections." [] synonym: "cystic thymic epithelial cells" EXACT [] synonym: "large medullary thymic epithelial cells" EXACT [] synonym: "large mTEC" EXACT [] xref: FMA:72214 is_a: CL:0002365 ! medullary thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:26Z [Term] id: CL:0002296 name: type-4 epithelial cell of thymus namespace: cell def: "An epithelial cell with high nuclear and cytoplasmic electron-density. This cell type is found in the deeper portions of the cortex but is more abundant in the medulla of the thymus." [] synonym: "dark thymic epithelial cell" EXACT [] xref: FMA:72212 is_a: CL:0002364 ! cortical thymic epithelial cell is_a: CL:0002365 ! medullary thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:45Z [Term] id: CL:0002297 name: type-3 epithelial cell of thymus namespace: cell def: "A thymic epithelial cell with moderate nuclear and cytoplasmic electron-density. Scattered in the cortex, this cell type is predominant in the mid and deep cortex." [] synonym: "intermediate thymic epithelial cell" EXACT [] xref: FMA:72211 is_a: CL:0002364 ! cortical thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:51Z [Term] id: CL:0002298 name: type-5 epithelial cell of thymus namespace: cell def: "A thymic epithelial cell type with low nuclear and cytoplasmic electrondensity; has a round, euchromatic nucleus and occurs in small groups at the corticomedullary junction or scattered singly in the medulla." [] synonym: "undifferentiated medullary thymic epithelial cell" EXACT [] synonym: "undifferentiated mTEC" EXACT [] synonym: "undifferentiated thymic epithelial cell" EXACT [] xref: FMA:72213 is_a: CL:0002365 ! medullary thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:54Z [Term] id: CL:0002299 name: type-2 epithelial cell of thymus namespace: cell def: "An epithelial cell scattered in the cortex, predominant in the outer cortex with a large pale nucleus and a prominent nucleolus." [] synonym: "pale thymic epithelial cell" EXACT [] xref: FMA:72210 is_a: CL:0002364 ! cortical thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:58Z [Term] id: CL:0002300 name: type-7 epithelial cell of thymus namespace: cell def: "A small medullary thymic epithelial cell with a spindle shape, often arranged in groups and connected to each other by large desmosomes and interdigitations. The cytoplasm is sparse, with scanty organelles and thick bundles of cytokeratin." [] synonym: "spindle shaped medullary thymic epithelial cell" EXACT [] synonym: "spindle shaped mTEC" EXACT [] is_a: CL:0002365 ! medullary thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T03:23:25Z [Term] id: CL:0002338 name: CD56-positive, CD161-positive immature natural killer cell, human namespace: cell def: "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-positive, CD117-positive, CD122-positive,and CD161-positive." [] comment: Human markers; killer cell immunoglobulin-like receptor 2DL1 is used as a representative example (PRO at this time lacks a KIR superfamily). synonym: "p-NK" RELATED [] is_a: CL:0000823 ! immature natural killer cell created_by: tmeehan creation_date: 2010-09-21T10:06:53Z [Term] id: CL:0002343 name: decidual natural killer cell, human namespace: cell def: "A natural killer cell subset that is found in the decidual of the uterus and is CD56-high, Galectin-1-positive and CD16-negative. This cell type represents the most abundant immune cell type in the decidual during the first trimester of pregnancy." [] synonym: "decidual NK cell" EXACT [] synonym: "dNK cell" EXACT [] is_a: CL:0000824 ! mature natural killer cell created_by: tmeehan creation_date: 2010-09-20T04:00:02Z [Term] id: CL:0002344 name: CD56-negative, CD161-positive immature natural killer cell, human namespace: cell def: "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-negative, CD117-positive, CD122-positive,and CD161-positive." [] comment: Human markers; killer cell immunoglobulin-like receptor 2DL1 is used as a representative example (PRO at this time lacks a KIR superfamily). synonym: "p-NK" RELATED [] is_a: CL:0000823 ! immature natural killer cell created_by: tmeehan creation_date: 2010-09-20T04:33:11Z [Term] id: CL:0002345 name: CD27-low, CD11b-low immature natural killer cell, mouse namespace: cell def: "An immature natural killer cell that is NK1.1-positive, DX5-positive, Ly49-positive, CD27-low and CD11b-low. This cell type is found in high numbers in the liver." [] comment: Markers are associated with mouse cells. synonym: "preNK.BM" BROAD [] is_a: CL:0000823 ! immature natural killer cell created_by: tmeehan creation_date: 2010-09-20T04:41:01Z [Term] id: CL:0002346 name: Dx5-negative, NK1.1-positive immature natural killer cell, mouse namespace: cell def: "An immature natural killer cell that is NK1.1-positive and DX-5 negative." [] is_a: CL:0000823 ! immature natural killer cell created_by: tmeehan creation_date: 2010-09-21T10:11:44Z [Term] id: CL:0002347 name: CD27-high, CD11b-high natural killer cell, mouse namespace: cell def: "A mature natural killer cell that is CD27-high and CD11b-high. This cell type is capable of interferon-gamma secretion." [] is_a: CL:0000824 ! mature natural killer cell created_by: tmeehan creation_date: 2010-09-21T10:19:49Z [Term] id: CL:0002348 name: CD27-low, CD11b-high natural killer cell, mouse namespace: cell def: "A CD27-low, CD11b-high natural killer cell that has a higher threshold of activation due to higher expression of inhibitory receptors." [] is_a: CL:0000824 ! mature natural killer cell created_by: tmeehan creation_date: 2010-09-21T10:19:54Z [Term] id: CL:0002349 name: CD27-high, CD11b-low natural killer cell, mouse namespace: cell def: "A natural killer cell that is CD27-high and CD11b-low." [] is_a: CL:0000824 ! mature natural killer cell created_by: tmeehan creation_date: 2010-09-21T10:20:00Z [Term] id: CL:0002364 name: cortical thymic epithelial cell namespace: cell def: "An epithelial cell of the cortical portion of the thymus. Epithelial cells in this region are required for positive selection of CD8-positive T cells." [] synonym: "cTEC" EXACT [] xref: BTO:0004562 is_a: CL:0002293 ! epithelial cell of thymus relationship: part_of UBERON:0002123 ! cortex of thymus created_by: tmeehan creation_date: 2010-09-23T03:17:12Z [Term] id: CL:0002365 name: medullary thymic epithelial cell namespace: cell def: "An epithelial cell of the medullary thymus. This cell type expresses a diverse range of tissue-specific antigens. This promiscuous gene expression is a cell-autonomous property of medullary epithelial cells and is maintained during the entire period of thymic T cell output." [] synonym: "mTEC" EXACT [] xref: BTO:0004563 is_a: CL:0002293 ! epithelial cell of thymus relationship: part_of UBERON:0002124 ! medulla of thymus created_by: tmeehan creation_date: 2010-09-23T03:17:14Z [Term] id: CL:0002378 name: immature Vgamma2-positive fetal thymocyte namespace: cell def: "A double negative thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive and is found in the fetal thymus." [] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "fetal Vgamma2+ thymocyte" BROAD [] is_a: CL:0002404 ! fetal thymocyte created_by: tmeehan creation_date: 2010-10-07T02:21:07Z [Term] id: CL:0002393 name: intermediate monocyte namespace: cell def: "A monocyte that has characteristics of both patrolling and inflammatory monocytes." [] is_a: CL:0000576 ! monocyte created_by: tmeehan creation_date: 2010-10-04T10:52:03Z [Term] id: CL:0002394 name: CD141-positive myeloid dendritic cell namespace: cell def: "A myeloid dendritic cell found in the blood, lymph nodes, tonsil, bone marrow, and spleen that is CD141-positive (BDCA-3), XCR1-positive, and Clec9A-positive. This cell-type can cross-present antigen to CD8-positive T cells and can produce inteferon-beta." [] comment: Markers are found in human cells. Normally they represent 3-5% of peripheral blood mDCs (human). These cells express high levels of CD283 (TLR3), are capable of producing IL-12p70 and IFN-beta upon stimulation, and inducing a TH1 response [PMCID:PMC2882828]. They are also Necl2-positive. May be human equivalent of murine CD8alpha-positive DCs. is_a: CL:0000782 ! myeloid dendritic cell is_a: CL:0000784 ! plasmacytoid dendritic cell created_by: tmeehan creation_date: 2010-10-04T02:38:58Z [Term] id: CL:0002395 name: Gr1-high classical monocyte namespace: cell def: "A resident monocyte that is Gr-1 high, CD43-negative, CX3CR1-negative, CD115-positive, and B220-negative." [] comment: Markers are associated with mice. The Gr epitope is used to describe this cell type is found on both Ly6c and Ly6g. However, its the Ly6c that is considered the specific marker, and thus used in the cross-product. is_a: CL:0000860 ! classical monocyte is_a: CL:0001022 ! CD115-positive monocyte created_by: tmeehan creation_date: 2010-10-04T11:26:18Z [Term] id: CL:0002396 name: CD14-low, CD16-positive monocyte namespace: cell def: "A patrolling monocyte that is CD14-low and CD16-positive." [] comment: Markers are associated with human monocytes. synonym: "non-classical monocyte, human" EXACT [] is_a: CL:0000875 ! non-classical monocyte is_a: CL:0001054 ! CD14-positive monocyte created_by: tmeehan creation_date: 2010-10-04T12:25:42Z [Term] id: CL:0002397 name: CD14-positive, CD16-positive monocyte namespace: cell def: "A CD14-positive monocyte that is also CD16-positive and CCR2-negative." [] comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16+ monocyte'. Markers are associated with human cells. Note that this cell type encompasses both human intermediate monocytes (CD14+, CD16-low), and human non-classical monocytes (CD14-low, CD16+). synonym: "CD16+ monocyte" EXACT [] is_a: CL:0001054 ! CD14-positive monocyte created_by: tmeehan creation_date: 2010-10-04T12:49:47Z [Term] id: CL:0002398 name: Gr1-positive, CD43-positive monocyte namespace: cell def: "An intermediate monocyte that is Gr1-positive, CD43-positive." [] is_a: CL:0001022 ! CD115-positive monocyte is_a: CL:0002393 ! intermediate monocyte created_by: tmeehan creation_date: 2010-10-04T12:49:49Z [Term] id: CL:0002399 name: CD1c-positive myeloid dendritic cell namespace: cell def: "A myeloid dendritic cell found in the blood that is CD1c-positive." [] comment: Normally represent 10-20% of peripheral blood mDCs (human). They are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD285-positive (TLR5), CD286-positive (TLR6), CD288-positive (TLR8), and CD290-positive (TLR10) [PMID:20204387]. Upon TLR stimulation, these cells were potent producers of CXCL8 (IL-8), while producing little TNF-alpha. is_a: CL:0000782 ! myeloid dendritic cell created_by: tmeehan creation_date: 2010-10-04T02:39:01Z [Term] id: CL:0002400 name: Fraction B/C precursor B cell namespace: cell def: "A precursor B cell that is AA4-positive, IgM-negative, CD19-positive, CD43-positive and HSA-positive." [] is_a: CL:0000817 ! precursor B cell created_by: tmeehan creation_date: 2010-10-05T10:11:38Z [Term] id: CL:0002401 name: mature dendritic epithelial T cell precursor namespace: cell def: "A thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18." [] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "mature DEC precursor" EXACT [] synonym: "mature DETC precursor" EXACT [] is_a: CL:0002404 ! fetal thymocyte created_by: tmeehan creation_date: 2010-10-07T02:05:46Z [Term] id: CL:0002402 name: Peyer's patch B cell namespace: cell def: "A resting mature B cell within the Peyer's patch that is CD19-positive, B220-positive, IgM-positive, AA4-negative, CD23-positive, CD43-negative, and CD5-negative." [] synonym: "Peyers patch B cell" EXACT [] is_a: CL:0000822 ! B-2 B cell is_a: CL:0009014 ! Peyer's patch lymphocyte created_by: tmeehan creation_date: 2010-10-05T11:18:03Z [Term] id: CL:0002403 name: mature Vgamma2-positive fetal thymocyte namespace: cell def: "A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus." [] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "fetal Vgamma2-positive" EXACT [] is_a: CL:0002404 ! fetal thymocyte created_by: tmeehan creation_date: 2010-10-07T02:24:36Z [Term] id: CL:0002404 name: fetal thymocyte namespace: cell def: "A thymocyte found in the fetal thymus." [] is_a: CL:0000893 ! thymocyte created_by: tmeehan creation_date: 2010-10-07T02:28:25Z [Term] id: CL:0002405 name: gamma-delta thymocyte namespace: cell def: "A post-natal thymocyte expressing components of the gamma-delta T cell receptor. This cell type is always double-negative (i.e. CD4-negative, CD8-negative)." [] synonym: "gammadelta thymocyte" EXACT [] synonym: "gd thymocyte" EXACT [] is_a: CL:0000798 ! gamma-delta T cell is_a: CL:0002489 ! double negative thymocyte created_by: tmeehan creation_date: 2010-10-07T02:33:39Z [Term] id: CL:0002406 name: immature Vgamma2-positive thymocyte namespace: cell def: "A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive." [] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "Vgamma2-positive thymocyte" BROAD [] is_a: CL:0002405 ! gamma-delta thymocyte created_by: tmeehan creation_date: 2010-10-07T02:53:44Z [Term] id: CL:0002407 name: mature Vgamma2-positive thymocyte namespace: cell def: "A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative." [] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "Vgamma2-positive" EXACT [] is_a: CL:0002405 ! gamma-delta thymocyte created_by: tmeehan creation_date: 2010-10-07T02:53:48Z [Term] id: CL:0002408 name: immature Vgamma2-negative thymocyte namespace: cell def: "A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain that does not contain a Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive." [] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "Vgamma2-negative thymocyte" BROAD [] is_a: CL:0002405 ! gamma-delta thymocyte created_by: tmeehan creation_date: 2010-10-07T02:59:05Z [Term] id: CL:0002409 name: mature Vgamma2-negative thymocyte namespace: cell def: "A thymocyte that has a T cell receptor consisting of a gamma chain that does not contain the Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative." [] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "Vgamma2-negative" EXACT [] is_a: CL:0002405 ! gamma-delta thymocyte created_by: tmeehan creation_date: 2010-10-07T02:59:08Z [Term] id: CL:0002411 name: Vgamma1.1-positive, Vdelta6.3-negative thymocyte namespace: cell def: "A gamma-delta receptor that expresses Vgamma1.1 but does not express Vdelta6.3 chains in the T-cell receptor." [] synonym: "Vg1.1-positive, Vd6.3-negative T cell" EXACT [] is_a: CL:0002405 ! gamma-delta thymocyte created_by: tmeehan creation_date: 2010-10-07T03:07:44Z [Term] id: CL:0002412 name: Vgamma1.1-positive, Vdelta6.3-positive thymocyte namespace: cell def: "A gamma-delta receptor that expresses Vgamma1.1-Vdelta6.3 chains in the T-cell receptor." [] synonym: "Vg1.1+Vd6.3+ T cell" EXACT [] is_a: CL:0002405 ! gamma-delta thymocyte created_by: tmeehan creation_date: 2010-10-07T03:03:00Z [Term] id: CL:0002413 name: mature Vgamma1.1-positive, Vdelta6.3-negative thymocyte namespace: cell def: "A Vgamma1.1-positive, Vdelta6.3-negative thymocyte that is CD24-negative." [] synonym: "mature Vg1.1-positive, Vd6.3-negative T cell" RELATED [] is_a: CL:0002411 ! Vgamma1.1-positive, Vdelta6.3-negative thymocyte created_by: tmeehan creation_date: 2010-10-07T03:10:32Z [Term] id: CL:0002414 name: immature Vgamma1.1-positive, Vdelta6.3-negative thymocyte namespace: cell def: "A Vgamma1.1-positive, Vdelta6.3-negative thymocyte that is CD24-positive." [] synonym: "immature Vg1.1-positive, Vd6.3-negative T cell" RELATED [] is_a: CL:0002411 ! Vgamma1.1-positive, Vdelta6.3-negative thymocyte created_by: tmeehan creation_date: 2010-10-07T03:10:35Z [Term] id: CL:0002415 name: immature Vgamma1.1-positive, Vdelta6.3-positive thymocyte namespace: cell def: "A Vgamma1.1-positive, Vdelta6.3-positive thymocyte that is CD24-positive." [] synonym: "immature Vg1.1+Vd6.3+ T cell" EXACT [] is_a: CL:0002412 ! Vgamma1.1-positive, Vdelta6.3-positive thymocyte created_by: tmeehan creation_date: 2010-10-07T03:10:39Z [Term] id: CL:0002416 name: mature Vgamma1.1-positive, Vdelta6.3-positive thymocyte namespace: cell def: "A Vgamma1.1-positive, Vdelta6.3-positive thymocyte that is CD24-negative." [] synonym: "mature Vg1.1+Vd6.3+ T cell" EXACT [] is_a: CL:0002412 ! Vgamma1.1-positive, Vdelta6.3-positive thymocyte created_by: tmeehan creation_date: 2010-10-07T03:10:41Z [Term] id: CL:0002419 name: mature T cell namespace: cell def: "A T cell that expresses a T cell receptor complex and has completed T cell selection." [] synonym: "CD3e-positive T cell" EXACT [] synonym: "CD3epsilon T cell" RELATED [] synonym: "mature T-cell" EXACT [] is_a: CL:0000084 ! T cell created_by: tmeehan creation_date: 2010-10-12T01:56:15Z [Term] id: CL:0002420 name: immature T cell namespace: cell def: "A T cell that has not completed T cell selection." [] synonym: "immature T-cell" EXACT [] xref: BTO:0001372 xref: CALOHA:TS-1042 is_a: CL:0000084 ! T cell created_by: tmeehan creation_date: 2010-10-12T01:56:17Z [Term] id: CL:0002423 name: DN2a thymocyte namespace: cell def: "A DN2 thymocyte that is Kit-hi." [] comment: Observed in mice. is_a: CL:0000806 ! DN2 thymocyte created_by: tmeehan creation_date: 2010-10-21T10:12:05Z [Term] id: CL:0002424 name: DN2b thymocyte namespace: cell def: "A DN2 thymocyte that is Kit-low." [] comment: Observed in mice. is_a: CL:0000806 ! DN2 thymocyte created_by: tmeehan creation_date: 2010-10-21T10:12:08Z [Term] id: CL:0002426 name: CD11b-positive, CD27-positive natural killer cell, mouse namespace: cell def: "A mature natural killer cell that is CD11b-positive and CD27-positive." [] comment: A natural killer cell that is NK1.1-positive, CD11b-positive, and CD27-positive. is_a: CL:0002438 ! NK1.1-positive natural killer cell, mouse created_by: tmeehan creation_date: 2010-10-25T03:07:59Z [Term] id: CL:0002427 name: resting double-positive thymocyte namespace: cell def: "A double-positive, alpha-beta thymocyte that is small and not proliferating." [] synonym: "T.DP.sm.Th" EXACT [] is_a: CL:0000809 ! double-positive, alpha-beta thymocyte created_by: tmeehan creation_date: 2010-10-21T01:59:06Z [Term] id: CL:0002428 name: double-positive blast namespace: cell def: "A double-positive thymocyte that is large (i.e. has a high forward scatter signal in flow cytometry) and is actively proliferating." [] synonym: "activated double-positive thymocyte" EXACT [] synonym: "T.DPb.Th" EXACT [] is_a: CL:0000809 ! double-positive, alpha-beta thymocyte created_by: tmeehan creation_date: 2010-10-21T01:59:11Z [Term] id: CL:0002429 name: CD69-positive double-positive thymocyte namespace: cell def: "A double-positive thymocyte that is CD69-positive and has begun positive selection." [] synonym: "T.DP69+.Th" EXACT [] is_a: CL:0000809 ! double-positive, alpha-beta thymocyte created_by: tmeehan creation_date: 2010-10-21T02:11:52Z [Term] id: CL:0002430 name: CD4-intermediate, CD8-positive double-positive thymocyte namespace: cell def: "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor." [] synonym: "T.4int8+.Th" EXACT [] is_a: CL:0000809 ! double-positive, alpha-beta thymocyte created_by: tmeehan creation_date: 2010-10-21T02:29:19Z [Term] id: CL:0002431 name: CD4-positive, CD8-intermediate double-positive thymocyte namespace: cell def: "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD8 co-receptor." [] synonym: "T.4int8+.th" EXACT [] is_a: CL:0000809 ! double-positive, alpha-beta thymocyte created_by: tmeehan creation_date: 2010-10-21T02:29:23Z [Term] id: CL:0002432 name: CD24-positive, CD4 single-positive thymocyte namespace: cell def: "A CD4-positive, CD8-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor." [] comment: Described in the immgene database as being CD24-intermediate. synonym: "CD24-positive, CD4 single-positive semimature thymocyte" EXACT [] synonym: "T.4SP24int.Th" EXACT [] is_a: CL:0000810 ! CD4-positive, alpha-beta thymocyte created_by: tmeehan creation_date: 2010-10-21T02:43:52Z [Term] id: CL:0002433 name: CD69-positive, CD4-positive single-positive thymocyte namespace: cell def: "A CD4-positive, CD8-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive." [] synonym: "intermediate CD4-single-positive" EXACT [] synonym: "T.4SP69+.Th" EXACT [] is_a: CL:0000810 ! CD4-positive, alpha-beta thymocyte created_by: tmeehan creation_date: 2010-10-21T02:46:02Z [Term] id: CL:0002434 name: CD24-positive, CD8 single-positive thymocyte namespace: cell def: "A CD8-positive, CD4-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor." [] comment: Described in the immgene database as being CD24-intermediate. synonym: "CD24-positive, CD8 single-positive semimature thymocyte" EXACT [] synonym: "T.8SP24int.Th" EXACT [] is_a: CL:0000811 ! CD8-positive, alpha-beta thymocyte created_by: tmeehan creation_date: 2010-10-21T02:59:10Z [Term] id: CL:0002435 name: CD69-positive, CD8-positive single-positive thymocyte namespace: cell def: "A CD8-positive, CD4-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive." [] synonym: "intermediate CD8-single-positive" EXACT [] synonym: "T.8SP69+.Th" EXACT [] is_a: CL:0000811 ! CD8-positive, alpha-beta thymocyte created_by: tmeehan creation_date: 2010-10-21T02:59:14Z [Term] id: CL:0002436 name: mature CD4 single-positive thymocyte namespace: cell def: "A mature CD4-positive, CD8-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor." [] synonym: "T.4SP24-.Th" RELATED [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell created_by: tmeehan creation_date: 2010-10-21T03:31:19Z [Term] id: CL:0002437 name: mature CD8 single-positive thymocyte namespace: cell def: "A mature CD8-positive, CD4-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor." [] synonym: "T.8SP24-.Th" EXACT [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell created_by: tmeehan creation_date: 2010-10-21T03:51:50Z [Term] id: CL:0002438 name: NK1.1-positive natural killer cell, mouse namespace: cell def: "A mature NK cell that is NK1.1-positive." [] comment: Note: Nk1.1 expression is restricted to C57BL strains of laboratory mice. synonym: "NK.sp" EXACT [] synonym: "NK1.1-positive NK cell" EXACT [] is_a: CL:0000824 ! mature natural killer cell created_by: tmeehan creation_date: 2010-10-25T03:18:04Z [Term] id: CL:0002439 name: NKGA2-positive natural killer cell, mouse namespace: cell def: "A NK1.1-positive T cell that is NKGA2-positive." [] synonym: "NK.G2A+.SP" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell, mouse created_by: tmeehan creation_date: 2010-10-25T03:31:09Z [Term] id: CL:0002440 name: Ly49D-positive natural killer cell, mouse namespace: cell def: "A NK1.1-positive T cell that is Ly49D-positive." [] synonym: "NK.49D+.Sp" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell, mouse created_by: tmeehan creation_date: 2010-10-25T03:36:19Z [Term] id: CL:0002441 name: CD94-positive natural killer cell, mouse namespace: cell def: "A NK1.1-positive T cell that is CD94-positive." [] synonym: "NK.94+.Sp" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell, mouse created_by: tmeehan creation_date: 2010-10-25T03:36:28Z [Term] id: CL:0002442 name: CD94-negative, Ly49CI-negative natural killer cell, mouse namespace: cell def: "A NK1.1-positive T cell that is CD94-negative and Ly49Cl-negative." [] synonym: "CD94- Ly49I-negative NK cell" EXACT [] synonym: "NK.49Cl-94-.Sp" EXACT [] is_a: CL:0000623 ! natural killer cell created_by: tmeehan creation_date: 2010-10-25T03:56:21Z [Term] id: CL:0002443 name: Ly49CI-positive natural killer cell, mouse namespace: cell def: "A NK1.1-positive T cell that is Ly49Cl-positive." [] synonym: "Ly49I-positive NK cell" EXACT [] synonym: "NK.49Cl+.Sp" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell, mouse created_by: tmeehan creation_date: 2010-10-25T03:36:38Z [Term] id: CL:0002444 name: Ly49H-positive natural killer cell, mouse namespace: cell def: "A NK1.1-positive T cell that is Ly49H-positive." [] synonym: "LyH49H-positive" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell, mouse created_by: tmeehan creation_date: 2010-10-25T03:36:43Z [Term] id: CL:0002445 name: Ly49D-negative natural killer cell, mouse namespace: cell def: "A NK1.1-positive T cell that is Ly49D-negative." [] synonym: "NK.49D-.Sp" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell, mouse created_by: tmeehan creation_date: 2010-10-25T03:39:02Z [Term] id: CL:0002446 name: Ly49CI-negative natural killer cell, mouse namespace: cell def: "A NK1.1-positive T cell that is Ly49Cl-negative." [] synonym: "Ly49I-negative NK cell" EXACT [] synonym: "NK.49Cl-.Sp" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell, mouse created_by: tmeehan creation_date: 2010-10-25T03:52:04Z [Term] id: CL:0002447 name: CD94-negative natural killer cell, mouse namespace: cell def: "A NK1.1-positive T cell that is CD94-negative." [] synonym: "NK.94-.Sp" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell, mouse created_by: tmeehan creation_date: 2010-10-25T03:54:18Z [Term] id: CL:0002448 name: Ly49H-negative natural killer cell, mouse namespace: cell def: "A NK1.1-positive T cell that is Ly49H-negative." [] synonym: "LyH49H-negative" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell, mouse created_by: tmeehan creation_date: 2010-10-25T03:42:42Z [Term] id: CL:0002449 name: CD94-positive Ly49CI-positive natural killer cell, mouse namespace: cell def: "A NK1.1-positive T cell that is CD94-positive and Ly49Cl-positive." [] synonym: "NK.49Cl+94+.Sp" EXACT [] is_a: CL:0002441 ! CD94-positive natural killer cell, mouse is_a: CL:0002443 ! Ly49CI-positive natural killer cell, mouse created_by: tmeehan creation_date: 2010-10-25T03:56:27Z [Term] id: CL:0002454 name: Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell namespace: cell def: "Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8_alpha-negative and is CD205-positive." [] synonym: "DC.8-4-11b+" EXACT [] synonym: "spleen double-negative dendritic cell" EXACT [] is_a: CL:0002465 ! CD11b-positive dendritic cell created_by: tmeehan creation_date: 2010-11-22T01:10:28Z [Term] id: CL:0002455 name: CD8_alpha-negative plasmactyoid dendritic cell namespace: cell def: "A CD11c-low plasmacytoid dendritic cell that is CD8alpha-negative and CD4-positive." [] synonym: "DC.pDC.8-" EXACT [] is_a: CL:0000989 ! CD11c-low plasmacytoid dendritic cell created_by: tmeehan creation_date: 2010-11-22T01:27:37Z [Term] id: CL:0002456 name: CD8_alpha-positive plasmactyoid dendritic cell namespace: cell def: "A CD11c-low plasmacytoid dendritic cell that is CD8alpha-positive and CD4-positive." [] synonym: "DC.pDC.8+" EXACT [] is_a: CL:0000989 ! CD11c-low plasmacytoid dendritic cell created_by: tmeehan creation_date: 2010-11-22T01:23:07Z [Term] id: CL:0002457 name: epidermal Langerhans cell namespace: cell def: "A Langerhans cell that is in the epidermis and is CD45-positive, MHCII-positive, and CD11b-positive." [] is_a: CL:0000453 ! Langerhans cell is_a: CL:0002465 ! CD11b-positive dendritic cell created_by: tmeehan creation_date: 2010-11-22T03:57:57Z [Term] id: CL:0002458 name: langerin-positive dermal dendritic cell namespace: cell def: "A dermal dendritic cell that is langerin-positive and CD103-positive." [] is_a: CL:0001006 ! dermal dendritic cell is_a: CL:0002461 ! CD103-positive dendritic cell created_by: tmeehan creation_date: 2010-11-22T04:06:22Z [Term] id: CL:0002459 name: langerin-negative dermal dendritic cell namespace: cell def: "A dermal dendritic cell that is langerin-negative, CD103-negative, and CD11b-positive." [] is_a: CL:0001006 ! dermal dendritic cell created_by: tmeehan creation_date: 2010-11-22T04:09:44Z [Term] id: CL:0002460 name: CD8alpha-negative thymic conventional dendritic cell namespace: cell def: "A conventional thymic dendritic cell that is CD8alpha-negative." [] synonym: "DC.8-.Th" EXACT [] is_a: CL:0000941 ! thymic conventional dendritic cell created_by: tmeehan creation_date: 2010-11-23T10:58:53Z [Term] id: CL:0002461 name: CD103-positive dendritic cell namespace: cell def: "A conventional dendritic cell that is CD103-positive. This cell type is usually found in non-lymphoid tissue." [] is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 ! conventional dendritic cell created_by: tmeehan creation_date: 2010-11-23T01:32:43Z [Term] id: CL:0002462 name: adipose dendritic cell namespace: cell def: "A F4/80-negative dendritic cell located in adipose tissue." [] is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 ! conventional dendritic cell created_by: tmeehan creation_date: 2010-11-23T01:38:21Z [Term] id: CL:0002463 name: SIRPa-positive adipose dendritic cell namespace: cell def: "An adipose dendritic cell that is SIRPa-positive." [] synonym: "DC.SIRPa+.Ad" EXACT [] is_a: CL:0002462 ! adipose dendritic cell created_by: tmeehan creation_date: 2010-11-23T01:40:44Z [Term] id: CL:0002464 name: SIRPa-negative adipose dendritic cell namespace: cell def: "An adipose dendritic cell that is SIRPa-negative." [] synonym: "DC.SIRPa-.Ad" EXACT [] is_a: CL:0002462 ! adipose dendritic cell created_by: tmeehan creation_date: 2010-11-23T01:40:46Z [Term] id: CL:0002465 name: CD11b-positive dendritic cell namespace: cell def: "A conventional dendritic cell that expresses CD11b (ITGAM)." [] is_a: CL:0000990 ! conventional dendritic cell created_by: tmeehan creation_date: 2010-11-23T01:50:05Z [Term] id: CL:0002466 name: small intestine serosal dendritic cell namespace: cell def: "A CD11b-positive dendritic cell located in the serosal portion of the small intestine epithelium. This cell type is CD45-positive, MHC-II-positive, CD11c-low, CD103-negative." [] synonym: "DC.11cloSer.SI" EXACT [] is_a: CL:0002465 ! CD11b-positive dendritic cell created_by: tmeehan creation_date: 2010-11-23T02:00:21Z [Term] id: CL:0002467 name: Gr1-high myeloid suppressor cell namespace: cell def: "A myeloid suppressor cell that is Gr1-high and CD11c-negative." [] synonym: "MDS.Gr1hi" EXACT [] is_a: CL:0000889 ! myeloid suppressor cell created_by: tmeehan creation_date: 2010-11-23T02:15:12Z [Term] id: CL:0002468 name: Gr1-low myeloid suppressor cell namespace: cell def: "A myeloid suppressor cell that is Gr1-low and CD11c-positive." [] synonym: "MDS.Gr1lo" EXACT [] is_a: CL:0000889 ! myeloid suppressor cell created_by: tmeehan creation_date: 2010-11-23T02:19:43Z [Term] id: CL:0002469 name: MHC-II-negative classical monocyte namespace: cell def: "Gr1-high monocyte that lacks MHC-II receptor complex." [] synonym: "Mo.6C+II-" EXACT [] is_a: CL:0002395 ! Gr1-high classical monocyte created_by: tmeehan creation_date: 2010-11-23T03:27:12Z [Term] id: CL:0002470 name: MHC-II-positive classical monocyte namespace: cell def: "Gr1-high monocyte that has a MHC-II receptor complex." [] synonym: "Mo.6c+II" EXACT [] is_a: CL:0002395 ! Gr1-high classical monocyte created_by: tmeehan creation_date: 2010-11-23T03:30:21Z [Term] id: CL:0002471 name: MHC-II-negative non-classical monocyte namespace: cell def: "Gr1-low non-classical monocyte that lacks expression of a MHC-II complex." [] synonym: "Mo.6C-II-" EXACT [] is_a: CL:0002058 ! Gr1-low non-classical monocyte created_by: tmeehan creation_date: 2010-11-23T03:38:15Z [Term] id: CL:0002472 name: MHC-II-low non-classical monocyte namespace: cell def: "Gr1-low non-classical monocyte that has low to intermediate expression of the MHC-II complex." [] synonym: "Mo.6C-IIint" EXACT [] is_a: CL:0002058 ! Gr1-low non-classical monocyte created_by: tmeehan creation_date: 2010-11-23T03:47:53Z [Term] id: CL:0002473 name: MHC-II-high non-classical monocyte namespace: cell def: "Gr1-low non-classical monocyte that has high surface expression of a MHC-II complex." [] synonym: "Mo.6C-II+" EXACT [] is_a: CL:0002058 ! Gr1-low non-classical monocyte created_by: tmeehan creation_date: 2010-11-23T03:47:55Z [Term] id: CL:0002474 name: lymphoid MHC-II-negative classical monocyte namespace: cell def: "A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-negative, and CD11b-high." [] is_a: CL:0002469 ! MHC-II-negative classical monocyte created_by: tmeehan creation_date: 2010-11-23T04:00:52Z [Term] id: CL:0002475 name: lymphoid MHC-II-negative non-classical monocyte namespace: cell def: "A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-intermediate, and CD11b-high." [] is_a: CL:0002471 ! MHC-II-negative non-classical monocyte created_by: tmeehan creation_date: 2010-11-23T04:09:09Z [Term] id: CL:0002476 name: bone marrow macrophage namespace: cell def: "A tissue-resident macrophage located in the bone marrow. This cell type is B220-negative, CD3e-negative, Ly-6C-negative, CD115-positive, F4/80-positive." [] synonym: "MF.BM" RELATED [] xref: BTO:0004732 is_a: CL:0000864 ! tissue-resident macrophage is_a: CL:1001610 ! bone marrow hematopoietic cell created_by: tmeehan creation_date: 2010-11-23T04:19:25Z [Term] id: CL:0002477 name: adipose macrophage namespace: cell def: "A macrophage located in adipose tissue that is CD45-positive, CD11c-positive, and SIRPa-positive." [] is_a: CL:0000864 ! tissue-resident macrophage created_by: tmeehan creation_date: 2010-11-23T04:31:28Z [Term] id: CL:0002478 name: F4/80-negative adipose macrophage namespace: cell def: "An adipose macrophage that does not express F4/80but is MHC-II-positive. This cell type exhibits autofluorescence under typical flow cyometry conditions." [] synonym: "MF.Autofl.Ad" EXACT [] is_a: CL:0002477 ! adipose macrophage created_by: tmeehan creation_date: 2010-11-23T04:40:50Z [Term] id: CL:0002479 name: F4/80-positive adipose macrophage namespace: cell def: "An adipose macrophage that does not express MHC-II but is F4/80-positive." [] synonym: "MF.F480+.Ad" EXACT [] is_a: CL:0002477 ! adipose macrophage created_by: tmeehan creation_date: 2010-11-23T04:35:53Z [Term] id: CL:0002489 name: double negative thymocyte namespace: cell def: "A thymocyte that lacks expression of CD4 and CD8." [] comment: These are precursors to mature T cells; normally, they do not circulate, but are found in the thymus and they have not undergone rearrangement of the alpha and beta T cell receptor genes. synonym: "CD4-CD8- T cell" EXACT [] synonym: "double negative T cell" EXACT [] is_a: CL:0000893 ! thymocyte created_by: tmeehan creation_date: 2010-12-06T03:03:38Z [Term] id: CL:0002496 name: intraepithelial lymphocyte namespace: cell def: "A T cell that is located in the intestinal epithelium and is capable of a mucosal immune response." [] synonym: "IEL" EXACT [] synonym: "intraepithelial T cell" EXACT [] synonym: "intraepithelial T-cell" EXACT [] is_a: CL:0002419 ! mature T cell created_by: tmeehan creation_date: 2010-12-07T09:54:50Z [Term] id: CL:0002505 name: liver CD103-negative dendritic cell namespace: cell def: "A CD11b-positive dendritic cell that is CD11b-high, CD45-positive, MHC-II-positive and CD103-negative." [] synonym: "DC.103-11b+.Lv" EXACT [] is_a: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell created_by: tmeehan creation_date: 2011-01-21T01:27:41Z [Term] id: CL:0002506 name: liver CD103-positive dendritic cell namespace: cell def: "A CD11b-positive dendritic cell that is CD11b-low, CD45-positive, MHC-II-high and CD103-positive that is located in the liver." [] synonym: "DC.103+11b-.Lv" EXACT [] is_a: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is_a: CL:0002461 ! CD103-positive dendritic cell created_by: tmeehan creation_date: 2011-01-21T01:27:45Z [Term] id: CL:0002507 name: langerin-positive lymph node dendritic cell namespace: cell def: "A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-positive, MHC-II-positive, and CD4-negative and CD8a-negative." [] is_a: CL:0000990 ! conventional dendritic cell created_by: tmeehan creation_date: 2011-01-21T01:57:00Z [Term] id: CL:0002508 name: langerin-negative, CD103-negative lymph node dendritic cell namespace: cell def: "A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-negative, MHC-II-positive, and CD4-negative and CD8a-negative." [] is_a: CL:0000990 ! conventional dendritic cell created_by: tmeehan creation_date: 2011-01-21T02:13:58Z [Term] id: CL:0002509 name: CD103-positive, langerin-positive lymph node dendritic cell namespace: cell def: "A langerin-positive lymph node dendritic cell that is CD103-positive and CD11b-low." [] is_a: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is_a: CL:0002461 ! CD103-positive dendritic cell is_a: CL:0002507 ! langerin-positive lymph node dendritic cell created_by: tmeehan creation_date: 2011-01-21T02:07:54Z [Term] id: CL:0002510 name: CD103-negative, langerin-positive lymph node dendritic cell namespace: cell def: "A langerin-positive lymph node dendritic cell that is CD103-negative and CD11b-high." [] is_a: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is_a: CL:0002507 ! langerin-positive lymph node dendritic cell created_by: tmeehan creation_date: 2011-01-21T02:11:14Z [Term] id: CL:0002511 name: CD11b-low, CD103-negative, langerin-negative lymph node dendritic cell namespace: cell def: "A langerin-negative lymph node dendritic cell that is CD103-negative and CD11b-low." [] is_a: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is_a: CL:0002508 ! langerin-negative, CD103-negative lymph node dendritic cell created_by: tmeehan creation_date: 2011-01-21T02:22:15Z [Term] id: CL:0002512 name: CD11b-high, CD103-negative, langerin-negative lymph node dendritic cell namespace: cell def: "A langerin-negative lymph node dendritic cell that is CD103-negative and CD11b-high." [] is_a: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is_a: CL:0002508 ! langerin-negative, CD103-negative lymph node dendritic cell created_by: tmeehan creation_date: 2011-01-21T02:16:21Z [Term] id: CL:0002513 name: Vgamma5-positive CD8alpha alpha positive gamma-delta intraepithelial T cell namespace: cell def: "A CD8alpha alpha positive gamma-delta intraepithelial T cell that expresses a TCR encoded in part by the Vgamma5 gene segment." [] synonym: "tgd.vg5+.IEL" EXACT [] is_a: CL:0000802 ! CD8-alpha alpha positive, gamma-delta intraepithelial T cell created_by: tmeehan creation_date: 2011-01-24T10:22:18Z [Term] id: CL:0002514 name: Vgamma5-negative CD8alpha alpha positive gamma-delta intraepithelial T cell namespace: cell def: "A CD8alpha alpha positive gamma-delta intraepithelial T cell that does not express a TCR partially encoded by the Vgamma5 gene segment." [] synonym: "tgd.vg5-.IEL" EXACT [] is_a: CL:0000802 ! CD8-alpha alpha positive, gamma-delta intraepithelial T cell created_by: tmeehan creation_date: 2011-01-24T10:25:44Z [Term] id: CL:0002526 name: CD14-positive dermal dendritic cell namespace: cell def: "A dermal dendritic cell that is CD1a-negative and CD14-positive." [] comment: They are also CD11c-positive, CD40-positive, CD85j-positive (ILT-2), CD163-positive, CD205-positive (DEC205), CD207-negative (langerin), CD209-positive (DC-SIGN), CD274-positive (PD-L1), CD324-negative (E-cadherin), Factor XIIIa-positive, LOX-I-positive, CLEC6-positive, Dectin-1-positive, and DCIR-positive. Upon stimulation, these cells are capable of producing IL1-beta, IL6, IL8, IL10, IL12p40, IL19, IL20, IL24, TGF-beta, TNF-alpha, GM-CSF, and MCP1. They reside in the dermis. synonym: "CD14+ dermal DC" EXACT [] is_a: CL:0001006 ! dermal dendritic cell [Term] id: CL:0002527 name: immature CD14-positive dermal dendritic cell namespace: cell def: "An immature CD14-positive dermal dendritic cell is CD80-low, CD86-low, and MHCII-low." [] is_a: CL:0001009 ! immature dermal dendritic cell is_a: CL:0002526 ! CD14-positive dermal dendritic cell [Term] id: CL:0002528 name: mature CD14-positive dermal dendritic cell namespace: cell def: "A mature CD14-positive dermal dendritic cell is CD80-high, CD86-high, MHCII-high and is CD83-positive." [] is_a: CL:0001010 ! mature dermal dendritic cell is_a: CL:0002526 ! CD14-positive dermal dendritic cell [Term] id: CL:0002529 name: CD1a-positive dermal dendritic cell namespace: cell def: "A dermal dendritic cell that is CD1a-positive and CD14-negative." [] comment: Reside in the dermis. They are also CD11c-positive, CD40-positive, CD207-negative (langerin), CD209-negative (DC-SIGN), and CD324-negative (E-cadherin). When activated, they are capable of producing CXCL8 (IL-8) and IL-15. Possibly a precursor of Langerhans cells or equivalent of langerin-positive dermal DCs in the mouse. synonym: "CD1a+ dermal DC" EXACT [] is_a: CL:0001006 ! dermal dendritic cell [Term] id: CL:0002530 name: immature CD1a-positive dermal dendritic cell namespace: cell def: "An immature CD1a-positive dermal dendritic cell is CD80-low, CD86-low, and MHCII-low." [] is_a: CL:0001009 ! immature dermal dendritic cell is_a: CL:0002529 ! CD1a-positive dermal dendritic cell [Term] id: CL:0002531 name: mature CD1a-positive dermal dendritic cell namespace: cell def: "A mature CD1a-positive dermal dendritic cell is CD80-high, CD83-positive, CD86-high, and MHCII-high." [] is_a: CL:0001010 ! mature dermal dendritic cell is_a: CL:0002529 ! CD1a-positive dermal dendritic cell [Term] id: CL:0002532 name: CD16-positive myeloid dendritic cell namespace: cell def: "A myeloid dendritic cell found in the blood that is CD16-positive." [] comment: Normally represent 65-75% of peripheral blood mDCs (human). They are also CD281-positive (TLR1), CD282-positive (TLR2), CD284-positive (TLR4), CD285-positive (TLR5), CD286-positive (TLR6), CD288-positive (TLR8), CD289-positive (TLR9), and CD290-positive (TLR10) by RT-PCR [PMID:17332250]. Upon TLR stimulation, these cells are potent producers of TNF-alpha, while producing little CXCL8 (IL8). synonym: "CD16+ mDC" EXACT [] synonym: "CD16-mDC" EXACT [] is_a: CL:0000782 ! myeloid dendritic cell [Term] id: CL:0002533 name: immature CD16-positive myeloid dendritic cell namespace: cell def: "An immature CD16-positive myeloid dendritic cell is CD80-low, CD86-low, and MHCII-low." [] is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0002532 ! CD16-positive myeloid dendritic cell [Term] id: CL:0002534 name: mature CD16-positive myeloid dendritic cell namespace: cell def: "A mature CD16-positive myeloid dendritic cell is CD80-high, CD83-positive, CD86-high, and MHCII-high." [] is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0002532 ! CD16-positive myeloid dendritic cell [Term] id: CL:0002540 name: mesenchymal stem cell of the bone marrow namespace: cell def: "A mesenchymal stem cell that is part of the bone marrow." [] is_a: CL:0002092 ! bone marrow cell created_by: tmeehan creation_date: 2011-02-28T01:47:47Z [Term] id: CL:0002554 name: fibroblast of lymphatic vessel namespace: cell def: "A fibroblast of the lymphatic system." [] relationship: part_of UBERON:0001473 ! lymphatic vessel created_by: tmeehan creation_date: 2011-02-28T05:16:18Z [Term] id: CL:0002628 name: immature microglial cell namespace: cell def: "An immature microglial cell with a ramified morphology." [] comment: Immature microglia are reportedly CD34-positive, CD163-negative, MHCI-negative, MHCII-negative. synonym: "immature microglia" EXACT [] synonym: "quiescent microglia" EXACT [] synonym: "resting microglia" EXACT [] is_a: CL:0000129 ! microglial cell [Term] id: CL:0002629 name: mature microglial cell namespace: cell def: "A mature microglial cell that has changed shape to an amoeboid morphology and is capable of cytokine production and antigen presentation." [] comment: Mature microglia are reportedly CCR2-positive, CD4-positive, CD9-positive, CD11a-positive, CD11b-positive, CD11c-positive, CD13-positive, CD16-positive, CDw17-positive, CD18-positive, CD21-positive, CD26-negative, CD32-positive, CD35-positive, CD36-positive, CD40-positive, CD44-positive, CD45-positive, CD53-positive, CD54-positive, CD56-negative, CD58-positive, CD63-positive, CD64-positive, CD66-positive, CD80-positive, CD86-positive, CD87-positive, CD92-positive, CD106-positive, CD107a-positive, CD147-positive, CD155-positive, CD162-positive, CD163-positive, CD171-negative, CD200R-positive, CXCR3-positive, CX3CR1-positive, fibronectin-positive, GD3-positive, GLUT1-positive, GLUT3-negative, GLUT5-positive, MHCI-positive, MHCII-positive, P2X4-positive, RFD7-negative, RGS5-negative, alpha-SMA-negative, vimentin-positive, and vwf-negative. Mature microglia are capable of producing BDNF, CCL3, CCL5, CCL7, CCL8, CCL9, CCL19, CCL20,CD40L, CSF, CXCL1, CXCL2, CXCL4, CXCL5, CXCL8, CXCL9, CXCL10, glutamate, IL-1beta, IL-1ra, IL-3, IL-6, IL-10, IL-12, LT, MMP-2, MMP-9, NGF, nitric oxide, ROS, TGF-beta, TNF-alpha. synonym: "activated microglia" EXACT [] synonym: "mature microglia" EXACT [] synonym: "reactive microglia" EXACT [] is_a: CL:0000129 ! microglial cell [Term] id: CL:0002677 name: naive regulatory T cell namespace: cell def: "A regulatory T cell that has not encountered antigen." [] comment: This cell type has been described as CD45RA-negative, but this doesn't fit with our current definition of naive T cell. synonym: "naive regulatory T lymphocyte" EXACT [] synonym: "naive regulatory T-cell" EXACT [] synonym: "naive regulatory T-lymphocyte" EXACT [] is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell is_a: CL:0000898 ! naive T cell created_by: tmeehan creation_date: 2011-08-25T03:17:21Z [Term] id: CL:0002678 name: memory regulatory T cell namespace: cell def: "A CD4-positive, CD25-positive alpha-beta regulatory T cell that has encountered antigen." [] comment: Cell has been described as being CD45RA-positive in human, but this doesn't fit with our current definition memory T cell. is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell is_a: CL:0000897 ! CD4-positive, alpha-beta memory T cell created_by: tmeehan creation_date: 2011-08-25T03:17:34Z [Term] id: CL:0002679 name: natural helper lymphocyte namespace: cell def: "A lymphocyte found in adipose tissue that lacks lineage markers of other lymphocytes but is capable of mediating TH2 cytokine responses. This cell type is found in fat associated lymphoid clusters, proliferates in response to IL2 and produce large amounts of TH2 cytokines such as IL5, IL6 and IL13" [] is_a: CL:0000542 ! lymphocyte created_by: tmeehan creation_date: 2011-08-29T10:08:02Z [Term] id: CL:0009014 name: Peyer's patch lymphocyte def: "A lymphocyte that is part of a Peyer's patch. These cells have a major role in driving the immune response to antigens sampled from the intestinal lumen, and in regulating the formation of follicle-associated epithelium and M cells in Peyer's patches by converting intestitial enterocytes into M cells." [] synonym: "Peyer's patch resident lymphocyte" EXACT [] synonym: "small intestine Peyer's patch lymphocyte" NARROW [] xref: https://orcid.org/0000-0003-4183-8865 is_a: CL:0000542 ! lymphocyte relationship: part_of UBERON:0001211 ! Peyer's patch property_value: location_grouping "" xsd:string created_by: http://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009015 name: Peyer's patch follicular dendritic cell def: "A follicular dendritic cell located in the Peyer's patch. These cells from a meshwork in which Peyer's patch B cells reside." [] xref: https://orcid.org/0000-0003-4183-8865 xref: PMID:24437401 relationship: part_of UBERON:0001211 ! Peyer's patch property_value: location_grouping "" xsd:string created_by: http://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009018 name: lymphocyte of large intestine lamina propria def: "A lymphocyte that resides in the lamina propria of the large intestine." [] synonym: "lamina propria lymphocyte of large intestine" EXACT [] xref: https://orcid.org/0000-0003-4183-8865 is_a: CL:0000542 ! lymphocyte property_value: location_grouping "" xsd:string created_by: http://orcid.org/0000-0002-2825-0621 [Term] id: CL:0010001 name: stromal cell of bone marrow def: "A stromal cell that is part_of a bone marrow." [] synonym: "bone marrow stromal cell" EXACT [] is_a: CL:0002092 ! bone marrow cell created_by: GOC:cjm [Term] id: CL:0010004 name: mononuclear cell of bone marrow def: "A mononuclear cell that is part_of a bone marrow." [] synonym: "bone marrow mononuclear cell" EXACT [] is_a: CL:0000842 ! mononuclear cell is_a: CL:1001610 ! bone marrow hematopoietic cell created_by: GOC:cjm [Term] id: CL:0011024 name: double negative T regulatory cell def: "A double negative thymocyte that is CD3-positive, CD4-negative, CD8-negative, that that are present in the periphery in very low numbers and predominantly produce INF-gamma, TNF-alpha, and a low amount of TGF-beta, but not IL-2, IL-4, IL-10 or IL-13 upon activation." [] synonym: "CD4-negative, CD8-negative, alpha-beta regulatory T cells" EXACT [] synonym: "DN Treg" EXACT [] synonym: "double-negative alpha-beta regulatory T cell" EXACT [] is_a: CL:0002489 ! double negative thymocyte created_by: http://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011025 name: exhausted T cell synonym: "An effector T cell that displays impaired effector functions (e.g., rapid production of effector cytokines, cytotoxicity) and has limited proliferative potential." EXACT [] synonym: "Tex cell" EXACT [] is_a: CL:0000911 ! effector T cell created_by: http://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011114 name: segmented neutrophil of bone marrow def: "A segmented neutrophilic cell of the bone marrow reserve pool that expresses CD11b (integrin alpha-M) and high levels of CD16 (low affinity immunoglobulin gamma Fc region receptor III) on its cell surface." [] is_a: CL:0000096 ! mature neutrophil is_a: CL:1001610 ! bone marrow hematopoietic cell [Term] id: CL:0019015 name: lung parenchyma resident eosinophil def: "An eosinophil with a ring-shaped nucleus that is resident in the lung parenchyma. In mouse, lung parenchyma resident eosinophils are IL-5-independent Siglec-F(intermediate) CD62L+ CD101(low). In human, they are Siglec-8+ CD62L+ IL-3R(low)." [] synonym: "lung-resident eosinophil" EXACT [] synonym: "rEos" EXACT [] is_a: CL:0000774 ! band form eosinophil property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0003-2034-601X property_value: http://purl.org/dc/elements/1.1/date 2020-05-26T09:42:19Z xsd:dateTime [Term] id: CL:0019017 name: lymphatic vessel smooth muscle cell def: "A smooth muscle cell that is part of any lymphatic vessel." [] synonym: "smooth muscle cell of lymphatic vessel" EXACT [] relationship: part_of UBERON:0001473 ! lymphatic vessel property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0003-2034-601X property_value: http://purl.org/dc/elements/1.1/date 2020-07-21T12:29:51Z xsd:dateTime [Term] id: CL:1000397 name: endothelial cell of venous sinus of red pulp of spleen namespace: cell def: "An endothelial cell that is part of the venous sinus of red pulp of spleen." [] comment: todo - add logical definition to UBERON:0009967 xref: FMA:62817 is_a: CL:2000053 ! splenic endothelial cell relationship: part_of UBERON:0009967 ! spleen venous sinus [Term] id: CL:1000411 name: endothelial cell of Peyer's patch namespace: cell def: "An endothelial cell that is part of the small intestine Peyer's patch." [] xref: FMA:67757 relationship: part_of UBERON:0003454 ! small intestine Peyer's patch [Term] id: CL:1000489 name: reticular cell of splenic cord namespace: cell def: "A reticular cell that is part of the splenic cord." [] xref: FMA:86497 is_a: CL:2000051 ! splenic fibroblast relationship: part_of UBERON:0001266 ! splenic cord [Term] id: CL:1000695 name: kidney interstitial alternatively activated macrophage namespace: cell xref: KUPO:0001106 is_a: CL:0000890 ! alternatively activated macrophage [Term] id: CL:1000696 name: kidney interstitial inflammatory macrophage namespace: cell xref: KUPO:0001107 is_a: CL:0000863 ! inflammatory macrophage [Term] id: CL:1000697 name: kidney interstitial suppressor macrophage namespace: cell xref: KUPO:0001108 is_a: CL:0000862 ! suppressor macrophage [Term] id: CL:1000698 name: kidney resident macrophage namespace: cell xref: KUPO:0001109 is_a: CL:0000864 ! tissue-resident macrophage [Term] id: CL:1000699 name: kidney resident dendritic cell namespace: cell xref: KUPO:0001110 is_a: CL:0001007 ! interstitial dendritic cell [Term] id: CL:1001577 name: tonsil squamous cell def: "Squamous cell of tonsil epithelium." [] synonym: "tonsil squamous epithelial cell" RELATED [] synonym: "tonsil squamous epithelial cells" RELATED [] synonym: "tonsillar squamous cell" RELATED [] synonym: "tonsillar squamous epithelial cell" RELATED [] xref: CALOHA:TS-1253 relationship: part_of UBERON:0013696 ! tonsil epithelium [Term] id: CL:1001603 name: lung macrophage def: "Circulating macrophages and tissue macrophages (alveolar macrophages) of lung." [] synonym: "lung macrophages" RELATED [] xref: CALOHA:TS-0576 is_a: CL:0000235 ! macrophage [Term] id: CL:1001610 name: bone marrow hematopoietic cell def: "Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes." [] synonym: "bone marrow hematopoietic cells" RELATED [] synonym: "bone marrow poietic cells" RELATED [] xref: CALOHA:TS-2109 is_a: CL:0002092 ! bone marrow cell [Term] id: CL:2000001 name: peripheral blood mononuclear cell namespace: cell def: "A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood." [] is_a: CL:0000842 ! mononuclear cell created_by: TermGenie creation_date: 2014-02-11T17:29:04Z [Term] id: CL:2000006 name: tonsil germinal center B cell namespace: cell def: "Any germinal center B cell that is part of a tonsil." [] is_a: CL:0000844 ! germinal center B cell relationship: part_of UBERON:0002372 ! tonsil created_by: TermGenie creation_date: 2014-03-28T21:35:33Z [Term] id: CL:2000011 name: dermis lymphatic vessel endothelial cell namespace: cell def: "Any endothelial cell of lymphatic vessel that is part of a dermis." [] is_a: CL:0002138 ! endothelial cell of lymphatic vessel created_by: TermGenie creation_date: 2014-06-04T15:15:08Z [Term] id: CL:2000041 name: dermis microvascular lymphatic vessel endothelial cell namespace: cell def: "Any dermis lymphatic vessel endothelial cell that is part of a microvascular endothelium." [] is_a: CL:2000011 ! dermis lymphatic vessel endothelial cell created_by: TermGenie creation_date: 2014-07-09T00:09:54Z [Term] id: CL:2000051 name: splenic fibroblast namespace: cell def: "Any fibroblast that is part of a spleen." [] relationship: part_of UBERON:0002106 ! spleen created_by: TermGenie creation_date: 2014-10-06T18:58:47Z [Term] id: CL:2000053 name: splenic endothelial cell namespace: cell def: "Any endothelial cell that is part of a spleen." [] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=5500 relationship: part_of UBERON:0002106 ! spleen created_by: TermGenie creation_date: 2014-10-06T19:06:04Z [Term] id: CL:2000054 name: hepatic pit cell namespace: cell def: "A large, granular, liver specific natural killer cell that adheres to the endothelial cells of the hepatic sinusoid." [] comment: Pit cells are named for the presence of large cytoplasmic granules that resemble pits (pips) of fruit. is_a: CL:0000623 ! natural killer cell [Term] id: CL:2000055 name: liver dendritic cell namespace: cell def: "Any dendritic cell that is part of a liver." [] comment: http://www.jleukbio.org/content/66/2/322.abstract synonym: "hepatic dendritic cell" EXACT [] is_a: CL:0000451 ! dendritic cell created_by: TermGenie creation_date: 2014-10-06T19:16:11Z [Term] id: CL:2000074 name: splenocyte namespace: cell def: "Any leukocyte that is part of a spleen." [] comment: Splenocytes is a vague term that refers to any one of the different white blood cell types in the spleen. This name is seen many references as such and is not explained further, necessitating a need for this terminology. is_a: CL:0000738 ! leukocyte relationship: part_of UBERON:0002106 ! spleen created_by: TermGenie creation_date: 2014-11-05T01:26:50Z [Term] id: CL:2000079 name: mesenchymal stem cell of femoral bone marrow namespace: cell def: "Any mesenchymal stem cell of the bone marrow that is part of a femur." [] is_a: CL:0002540 ! mesenchymal stem cell of the bone marrow created_by: TermGenie creation_date: 2014-12-02T19:07:31Z [Term] id: CL:2000085 name: mononuclear cell of umbilical cord namespace: cell def: "Any mononuclear cell that is part of a umbilical cord." [] is_a: CL:0000842 ! mononuclear cell created_by: TermGenie creation_date: 2014-12-02T20:14:16Z [Term] id: CL:3000001 name: Hofbauer cell namespace: cell def: "Oval eosinophilic histiocytes with granules and vacuoles found in placenta, which are of mesenchymal origin, in mesoderm of the chorionic villus, particularly numerous in early pregnancy." [] is_a: CL:0000235 ! macrophage created_by: CellBLAST creation_date: 2019-02-18T19:41:20Z [Term] id: UBERON:0000029 name: lymph node namespace: uberon def: "Any of the rounded masses of lymphoid tissue that are surrounded by a capsule of connective tissue, are distributed along the lymphatic vessels, and contain numerous lymphocytes which filter the flow of lymph." [BTO:0000784] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "lymph gland" RELATED [VHOG:0001273] synonym: "nodus lymphaticus" RELATED LATIN [http://en.wikipedia.org/wiki/Lymph_node] xref: BTO:0000784 xref: CALOHA:TS-0579 xref: EFO:0000872 xref: EMAPA:35523 xref: EV:0100050 xref: FMA:5034 xref: GAID:947 xref: galen:Lymphnode xref: http://linkedlifedata.com/resource/umls/id/C0024204 xref: http://www.snomedbrowser.com/Codes/Details/181756000 xref: Lymph:node xref: MA:0000139 xref: MAT:0000442 xref: MESH:D008198 xref: NCIT:C12745 xref: NCIT:C33027 xref: OpenCyc:Mx4rwLPqLpwpEbGdrcN5Y29ycA xref: TAO_RETIRED:0005318 xref: UMLS:C0024204 {source="ncithesaurus:Lymph_Node"} xref: VHOG:0001273 xref: ZFA_RETIRED:0005318 is_a: UBERON:0005057 ! immune organ relationship: part_of UBERON:0002465 ! lymphoid system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b8/Illu_lymph_node_structure.png xsd:anyURI property_value: seeAlso https://github.com/obophenotype/uberon/issues/650 xsd:anyURI property_value: UBPROP:0000003 "Lymph nodes that are associated with the lymphatic system have evolved in mammals.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001273", ontology="VHOG", source="http://bgee.unil.ch/", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.630"} [Term] id: UBERON:0000040 name: Leydig's organ namespace: uberon def: "A hemopoietic organ found in elasmobranchs. Along with the spleen and special tissue around the gonads, this structure produces red blood cells and it is nestled along the top and bottom of the esophagus." [http://en.wikipedia.org/wiki/Leydig's_organ, http://www.elasmo-research.org/education/topics/p_blood_cells.htm] comment: Phenotype notes: Leydig's organ can be quite large - a 1.6-kilogram (3.5-pound) one was reported from a 1.8-metre (6-foot) long Bluntnose Sixgill Shark (Hexanchus griseus). Structure notes: divided into dorsal and ventral patches, gradation varies between species. Lacks erythroblasts and fat cells[Honma 1983] subset: uberon_slim xref: Leydig's:organ is_a: UBERON:0005057 ! immune organ property_value: UBPROP:0000008 "Found in elasmobranchs (sharks and rays) but with some exceptions." xsd:string [Term] id: UBERON:0000061 name: anatomical structure namespace: uberon def: "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome." [CARO:0000003] subset: upper_level synonym: "biological structure" EXACT [] synonym: "connected biological structure" EXACT [CARO:0000003] xref: AAO:0010825 xref: AEO:0000003 xref: BILA:0000003 xref: CARO:0000003 xref: EHDAA2:0003003 xref: EMAPA:0 xref: FBbt:00007001 xref: FMA:305751 xref: FMA:67135 xref: GAID:781 xref: HAO:0000003 xref: http://dbpedia.org/ontology/AnatomicalStructure xref: http://www.snomedbrowser.com/Codes/Details/362889002 xref: MA:0003000 xref: MESH:D000825 xref: TAO:0000037 xref: TGMA:0001823 xref: VHOG:0001759 xref: XAO:0003000 xref: ZFA:0000037 is_a: UBERON:0000465 ! material anatomical entity [Term] id: UBERON:0000332 name: yellow bone marrow namespace: uberon def: "bone marrow in which the fat cells predominate in the meshes of the reticular network." [http://medical-dictionary.thefreedictionary.com/Yellow+Marrow] synonym: "fat marrow" RELATED [BTO:0000635] synonym: "medulla ossium flava" EXACT LATIN [BTO:0000635] synonym: "yellow marrow" EXACT [BTO:0000635] xref: BTO:0000635 xref: FMA:74596 xref: http://www.snomedbrowser.com/Codes/Details/328639002 xref: http://www.snomedbrowser.com/Codes/Details/5023006 is_a: UBERON:0002371 ! bone marrow relationship: part_of UBERON:0007195 ! stroma of bone marrow [Term] id: UBERON:0000361 name: red bone marrow namespace: uberon def: "The red vascular substance consisting of connective tissue and blood vessels, containing primitive blood cells, macrophages, megakaryocytes, and fat cells. Red marrow is found in the cavities of many bones. It manufactures and releases leukocytes and erythrocytes into the bloodstream." [http://medical-dictionary.thefreedictionary.com/red+marrow] synonym: "medulla ossium rubra" EXACT LATIN [BTO:0001160] synonym: "parenchyma of none marrow marrow" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "parenchymal red marrow" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "red marrow" EXACT [BTO:0001160] xref: BTO:0001160 xref: FMA:74595 xref: http://www.snomedbrowser.com/Codes/Details/328538003 xref: http://www.snomedbrowser.com/Codes/Details/75330005 is_a: UBERON:0002371 ! bone marrow [Term] id: UBERON:0000363 name: reticuloendothelial system namespace: uberon def: "A part of the immune system that consists of the phagocytic cells located in reticular connective tissue. The cells are primarily monocytes and macrophages, and they accumulate in lymph nodes and the spleen. The Kupffer cells of the liver and tissue histiocytes are also part of the RES[WP]." [http://en.wikipedia.org/wiki/Reticuloendothelial_system] synonym: "lymphoreticular" RELATED [BioMart:BioMart] synonym: "lymphoreticular system" EXACT [http://en.wikipedia.org/wiki/Reticuloendothelial_system] synonym: "mononuclear phagocyte system" EXACT [FMA:84189] synonym: "RES" EXACT [http://en.wikipedia.org/wiki/Reticuloendothelial_system] synonym: "reticuloendothelial system" EXACT [FMA:84189] xref: BTO:0001174 xref: EV:0100048 xref: FMA:84189 xref: GAID:1004 xref: http://linkedlifedata.com/resource/umls/id/C0035287 xref: http://www.snomedbrowser.com/Codes/Details/278874002 xref: MESH:D012157 xref: NCIT:C12780 xref: Reticuloendothelial:system xref: UMLS:C0035287 {source="ncithesaurus:Reticuloendothelial_System"} is_a: UBERON:0000061 ! anatomical structure relationship: part_of UBERON:0002405 ! immune system [Term] id: UBERON:0000444 name: lymphoid follicle namespace: uberon def: "." [https://github.com/obophenotype/uberon/issues/6, https://github.com/obophenotype/uberon/issues/7] synonym: "folliculus lymphaticus" RELATED [BTO:0002684] synonym: "lymphatic follicle" RELATED [BTO:0002684] synonym: "lymphatic nodule" RELATED [BTO:0002684] synonym: "lymphoid nodule" EXACT [FMA:55222] synonym: "nodular lymphoid tissue" EXACT [FMA:55222] synonym: "nodulus lymphaticus" RELATED [BTO:0002684] synonym: "nodulus lymphoideus" RELATED [BTO:0002684] xref: BTO:0002684 xref: FMA:55222 xref: http://linkedlifedata.com/resource/umls/id/C0229654 xref: http://www.snomedbrowser.com/Codes/Details/64626006 xref: NCIT:C33040 xref: UMLS:C0229654 {source="ncithesaurus:Lymphoid_Follicle"} is_a: UBERON:0001744 {source="FMA"} ! lymphoid tissue property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/cmungall property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/tmeehan property_value: IAO:0000116 "introducing part_of to 'cortex of lymph node' as in issue 7 introduces equivalencies; the part_of has instead been added to 'lymph node follicle'" xsd:string [Term] id: UBERON:0000465 name: material anatomical entity namespace: uberon def: "Anatomical entity that has mass." [http://orcid.org/0000-0001-9114-8737] subset: upper_level xref: AAO:0010264 xref: AEO:0000006 xref: BILA:0000006 xref: CARO:0000006 xref: EHDAA2:0003006 xref: FBbt:00007016 xref: FMA:67165 xref: HAO:0000006 xref: TAO:0001836 xref: TGMA:0001826 xref: VHOG:0001721 is_a: BFO:0000040 ! material entity is_a: UBERON:0001062 ! anatomical entity [Term] id: UBERON:0000467 name: anatomical system namespace: uberon def: "Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function." [CARO:0000011] subset: pheno_slim subset: uberon_slim subset: upper_level synonym: "anatomical systems" RELATED PLURAL [ZFA:0001439] synonym: "body system" EXACT [BIRNLEX:14] synonym: "connected anatomical system" EXACT [CARO:0000011] synonym: "organ system" EXACT [] synonym: "system" BROAD [GO:0048731] xref: AAO:0000007 xref: AEO:0000011 xref: BILA:0000011 xref: BIRNLEX:14 xref: BSA:0000049 xref: CALOHA:TS-2088 xref: CARO:0000011 xref: EHDAA2:0003011 xref: EHDAA:392 xref: EMAPA:16103 xref: EV:0100000 xref: FBbt:00004856 xref: FMA:7149 xref: galen:AnatomicalSystem xref: HAO:0000011 xref: http://linkedlifedata.com/resource/umls/id/C0460002 xref: http://www.snomedbrowser.com/Codes/Details/278195005 xref: MA:0000003 xref: NCIT:C12919 xref: OpenCyc:Mx4rCWM0QCtDEdyAAADggVbxzQ xref: Organ:system xref: TAO:0001439 xref: TGMA:0001831 xref: UMLS:C0460002 {source="ncithesaurus:Organ_System"} xref: VHOG:0001725 xref: WBbt:0005746 xref: WBbt:0005763 xref: XAO:0003002 xref: ZFA:0001439 is_a: UBERON:0000061 ! anatomical structure property_value: seeAlso EHDAA2:0001330 [Term] id: UBERON:0001062 name: anatomical entity namespace: uberon def: "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species." [FMA:62955, http://orcid.org/0000-0001-9114-8737] subset: upper_level xref: AAO:0010841 xref: AEO:0000000 xref: BILA:0000000 xref: BIRNLEX:6 xref: CARO:0000000 xref: EHDAA2:0002229 xref: FBbt:10000000 xref: FBbt_root:00000000 xref: FMA:62955 xref: HAO:0000000 xref: http://linkedlifedata.com/resource/umls/id/C1515976 xref: MA:0000001 xref: NCIT:C12219 xref: TAO:0100000 xref: TGMA:0001822 xref: UMLS:C1515976 {source="ncithesaurus:Anatomic_Structure_System_or_Substance"} xref: WBbt:0000100 xref: XAO:0000000 xref: ZFA:0100000 is_a: BFO:0000004 ! independent continuant [Term] id: UBERON:0001097 name: axillary lymph node namespace: uberon def: "the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region" [ISBN:0-683-40008-8, MP:0002340] subset: pheno_slim subset: uberon_slim synonym: "axillary node" EXACT [] synonym: "nodi lymphoidei axillares" RELATED LATIN [http://en.wikipedia.org/wiki/Axillary_lymph_nodes] xref: FMA:276805 xref: http://en.wikipedia.org/wiki/Axillary_lymph_nodes xref: http://linkedlifedata.com/resource/umls/id/C0729594 xref: http://www.snomedbrowser.com/Codes/Details/181759007 xref: MA:0000735 xref: NCIT:C12904 xref: UMLS:C0729594 {source="ncithesaurus:Axillary_Lymph_Node"} is_a: UBERON:0003968 {source="CL:tm"} ! peripheral lymph node property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/73/Gray607.png xsd:anyURI [Term] id: UBERON:0001211 name: Peyer's patch namespace: uberon def: "the protruding lymphoid tissue located on the mucosa of the intestine that is composed of densely packed B cell follicles" [http://orcid.org/0000-0002-6601-2165, http://www.ncbi.nlm.nih.gov/pubmed/15841100, MESH:A10.549.600, MP:0000696] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "aggregated lymphoid follicle of intestine" RELATED [] synonym: "aggregated lymphoid nodule" RELATED [] synonym: "noduli lymphoidei aggregati" EXACT LATIN [] synonym: "Peyers gland" RELATED [BTO:0001784] synonym: "Peyers patch" RELATED [BTO:0001784] xref: BTO:0001784 xref: CALOHA:TS-0780 xref: EFO:0001381 xref: EMAPA:19028 xref: GAID:950 xref: http://linkedlifedata.com/resource/umls/id/C0031272 xref: MA:0000137 xref: MESH:A10.549.598 xref: NCIT:C12771 xref: Peyer's:patch xref: UMLS:C0031272 {source="ncithesaurus:Peyer_s_Patch"} is_a: UBERON:0001962 {source="FMA", source="MA"} ! gut-associated lymphoid tissue property_value: UBPROP:0000008 "Reptiles have accumulations of lymphocytes in their guts that may be primitive Peyer's patches (Zapata and Solas)." xsd:string property_value: UBPROP:0000012 "FMA has [set of?] [aggregated,small] lymphoid [follice,nodule] of [colon, SI, I, etc]" xsd:string {external_ontology="FMA"} property_value: UBPROP:0000012 "Pp is a syn for Aggregated lymphoid follicle of small intestine; but MA uses Pp as covering both SI and LI. MA also includes follicle as a part. WP says duodenum and jejunum lack PPs" xsd:string {external_ontology="MA"} [Term] id: UBERON:0001248 name: hilum of spleen namespace: uberon def: "The splenic hilum is a location on the surface of the spleen. It is the point of attachment for the gastrosplenic ligament, and the point of insertion for the splenic artery and splenic vein. [WP,unvetted]." [http://en.wikipedia.org/wiki/Splenic_hilum] subset: uberon_slim synonym: "hilum" BROAD [EMAPA:19303] synonym: "hilum lienale" EXACT LATIN [FMA:15841, FMA:TA] synonym: "hilum splenicum" EXACT LATIN [FMA:15841, FMA:TA] synonym: "hilum splenicum" RELATED LATIN [http://en.wikipedia.org/wiki/Splenic_hilum] synonym: "spleen hilum" EXACT [] synonym: "splenic hilum" EXACT [] xref: EMAPA:19303 xref: FMA:15841 xref: http://linkedlifedata.com/resource/umls/id/C0229685 xref: http://www.snomedbrowser.com/Codes/Details/245377005 xref: MA:0002670 xref: NCIT:C33601 xref: Splenic:hilum xref: UMLS:C0229685 {source="ncithesaurus:Splenic_Hilum"} relationship: part_of UBERON:0002106 ! spleen property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/a/a2/Gray1188.png xsd:anyURI [Term] id: UBERON:0001249 name: spleen lymphoid follicle namespace: uberon alt_id: UBERON:0003969 def: "The area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [CL:tm, https://github.com/obophenotype/uberon/issues/6, MP:0008470] subset: pheno_slim synonym: "lymphatic follicle of spleen" EXACT [FMA:15843] synonym: "lymphoid follicle of spleen" EXACT [FMA:15843] synonym: "lymphoid nodule of spleen" EXACT [FMA:15843] synonym: "Malpighian body" EXACT [FMA:15843] synonym: "spleen B cell follicle" EXACT [CL:tm] synonym: "spleen lymphoid follicle" EXACT [MA:0002672] synonym: "spleen lymphoid nodule" RELATED [MA:0002672] synonym: "splenic B cell follicle" EXACT [CL:tm] synonym: "splenic lymphatic follicle" EXACT [FMA:15843] synonym: "splenic lymphoid follicle" EXACT [] xref: EMAPA:35804 xref: http://linkedlifedata.com/resource/umls/id/C1519475 xref: http://www.snomedbrowser.com/Codes/Details/35845000 xref: MA:0002672 xref: NCIT:C33602 xref: UMLS:C1519475 {source="ncithesaurus:Splenic_Lymphoid_Follicle"} is_a: UBERON:0000444 ! lymphoid follicle relationship: part_of UBERON:0001959 {source="CL:tm", source="MA"} ! white pulp of spleen relationship: part_of UBERON:0006561 {source="FMA"} ! non-lymphatic part of lymphoid system property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/cmungall property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/tmeehan [Term] id: UBERON:0001250 name: red pulp of spleen namespace: uberon def: "the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith, MP:0002356] subset: pheno_slim subset: uberon_slim synonym: "pulpa rubra" EXACT LATIN [FMA:15844, FMA:TA] synonym: "pulpa splenica" RELATED LATIN [http://en.wikipedia.org/wiki/Red_pulp] synonym: "red pulp" EXACT [] synonym: "spleen red pulp" EXACT [] synonym: "splenic red pulp" EXACT [] xref: CALOHA:TS-1263 xref: EMAPA:35806 xref: FMA:15844 xref: http://linkedlifedata.com/resource/umls/id/C0229687 xref: http://www.snomedbrowser.com/Codes/Details/27579002 xref: MA:0000756 xref: NCIT:C12992 xref: Red:pulp xref: UMLS:C0229687 {source="ncithesaurus:Splenic_Red_Pulp"} is_a: UBERON:1000023 ! spleen pulp property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1191.png xsd:anyURI property_value: RO:0002175 NCBITaxon:7955 {source="https://doi.org/10.1177/0192623311409597"} [Term] id: UBERON:0001251 name: marginal zone of spleen namespace: uberon def: "the zone between the red and white pulp of the spleen containing numerous macrophages and lymphocytes, and a rich plexus of sinusoids supplied by white pulp arterioles carrying blood-borne antigens" [ISBN:0-683-40008-8, MP:0002362] subset: pheno_slim synonym: "junctional zone of spleen" EXACT [] synonym: "marginal zone" BROAD [http://en.wikipedia.org/wiki/Marginal_zone] synonym: "spleen marginal zone" EXACT [MA:0000755] xref: CALOHA:TS-2395 xref: EMAPA:36650 xref: FMA:15852 xref: http://linkedlifedata.com/resource/umls/id/C1711368 xref: MA:0000755 xref: Marginal:zone xref: NCIT:C49767 xref: UMLS:C1711368 {source="ncithesaurus:Marginal_Zone"} relationship: part_of UBERON:0002106 ! spleen property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1191.png xsd:anyURI property_value: UBPROP:0000012 "WP says - (Some sources consider it to be the part of red pulp which borders on the white pulp, while other sources consider it to be neither red pulp nor white pulp.) - we use the adjacency relation here so it overlaps neither. FMA considers this an anatomical line." xsd:string {external_ontology="FMA"} [Term] id: UBERON:0001265 name: trabecula of spleen namespace: uberon def: "A trabecula that is part of a spleen." [OBOL:automatic] synonym: "spleen trabeculum" EXACT [] synonym: "splenic trabecula" EXACT [] xref: EMAPA:35808 xref: FMA:16027 xref: http://en.wikipedia.org/wiki/Trabeculae_of_spleen xref: http://linkedlifedata.com/resource/umls/id/C0229688 xref: http://www.snomedbrowser.com/Codes/Details/61987002 xref: MA:0000758 xref: NCIT:C33607 xref: UMLS:C0229688 {source="ncithesaurus:Splenic_Trabecula"} relationship: part_of UBERON:1000024 {source="FMA"} ! parenchyma of spleen [Term] id: UBERON:0001266 name: splenic cord namespace: uberon def: "A structure found in the red pulp of the spleen between the sinusoids, consisting of fibrils and connective tissue cells with a large population of monocytes and macrophages. These cords contain half of the human body's monocytes as a reserve so that after tissue injury these monocytes can move in and aid locally sourced monocytes in wound healing. Erythrocytes pass through the cords of Billroth before entering the sinusoids. The passage into the sinusoids may be seen as a bottleneck, where erythrocytes need to be flexible in order to pass through. In disorders of erythrocyte shape and/or flexibility, such as hereditary spherocytosis, erythrocytes fail to pass through and get phagocytosed, causing extravascular hemolysis." [http://en.wikipedia.org/wiki/Cords_of_Billroth] synonym: "cord of Billroth" EXACT [http://en.wikipedia.org/wiki/Cords_of_Billroth] synonym: "cord of Bilroth" EXACT [FMA:16031] xref: EMAPA:37752 {source="MA:th"} xref: FMA:16031 xref: http://en.wikipedia.org/wiki/Cords_of_Billroth xref: http://linkedlifedata.com/resource/umls/id/C0735011 xref: MA:0002671 xref: NCIT:C33599 xref: UMLS:C0735011 {source="ncithesaurus:Splenic_Cord"} relationship: part_of UBERON:0001250 {source="MA"} ! red pulp of spleen [Term] id: UBERON:0001422 name: facial lymphatic vessel namespace: uberon def: "A lymphatic vessel that is part of a face [Automatically generated definition]." [OBOL:automatic] subset: vertebrate_core synonym: "buccal lymphatic vessel" EXACT [] synonym: "face lymph vessel" EXACT [OBOL:automatic] synonym: "face lymphatic vessel" EXACT [OBOL:automatic] synonym: "FL" RELATED [] synonym: "lymph vessel of face" EXACT [OBOL:automatic] synonym: "lymphatic vessel of face" EXACT [OBOL:automatic] xref: FMA:233946 xref: TAO:0005108 xref: ZFA:0005108 is_a: UBERON:0001473 ! lymphatic vessel relationship: part_of UBERON:0011363 ! cranial lymph vasculature [Term] id: UBERON:0001425 name: pectoral lymphatic vessel namespace: uberon subset: vertebrate_core synonym: "PL" RELATED ABBREVIATION [] xref: FMA:234865 xref: TAO:0005107 xref: ZFA:0005107 is_a: UBERON:0001473 ! lymphatic vessel [Term] id: UBERON:0001426 name: jugular lymphatic vessel namespace: uberon subset: vertebrate_core synonym: "JL" RELATED ABBREVIATION [] synonym: "JLV" BROAD ABBREVIATION [ZFA:0005109] xref: FMA:234908 xref: TAO:0005109 xref: ZFA:0005109 is_a: UBERON:0001473 ! lymphatic vessel [Term] id: UBERON:0001473 name: lymphatic vessel namespace: uberon def: "A vessel that contains or conveys lymph, that originates as an interfibrillar or intercellular cleft or space in a tissue or organ, and that if small has no distinct walls or walls composed only of endothelial cells and if large resembles a vein in structure[BTO]." [BTO:0000752, http://en.wikipedia.org/wiki/Lymphatic_vessel] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "lymph vessel" EXACT [] synonym: "vas lymphaticum" RELATED LATIN [http://en.wikipedia.org/wiki/Lymphatic_vessel] xref: AAO:0011005 xref: BTO:0000752 xref: CALOHA:TS-2102 xref: EFO:0000873 xref: EMAPA:35532 xref: FMA:30315 xref: http://linkedlifedata.com/resource/umls/id/C0229889 xref: http://www.snomedbrowser.com/Codes/Details/279089004 xref: Lymphatic:vessel xref: MA:0000138 xref: MAT:0000443 xref: NCIT:C33038 xref: OpenCyc:Mx4rwA1fYZwpEbGdrcN5Y29ycA xref: TAO:0005105 xref: UMLS:C0229889 {source="ncithesaurus:Lymphatic_Vessel"} xref: VHOG:0001249 xref: XAO:0000375 relationship: part_of UBERON:0004536 ! lymph vasculature property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/4/44/Illu_lymph_capillary.jpg xsd:anyURI property_value: RO:0002174 NCBITaxon:8342 {source="https://doi.org/10.1152/japplphysiol.00201.2013"} property_value: UBPROP:0000001 "A network of blunt ended vessels lacking direct connection to the blood vascular system. These vessels collect and drain fluids and macromolecules from interstitial spaces throughout the animal. They derive from a subpopulation of endothelial cells and have walls that are much thinner than the blood carrying vessels. Lymphatic vessels are usually classified as either superficial or deep.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005105", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "A vessel that contains or conveys lymph.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011005", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000003 "Tetrapods have evolved distinct lymphatic systems, in which lymphatic capillaries help drain most of the tissues of the body.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001249", ontology="VHOG", source="http://bgee.unil.ch/", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.627"} [Term] id: UBERON:0001542 name: inguinal lymph node namespace: uberon def: "the lymph nodes located in the groin area" [MGI:cwg, MP:0002353] subset: pheno_slim subset: uberon_slim xref: EMAPA:35431 xref: FMA:44226 xref: http://en.wikipedia.org/wiki/Inguinal_lymph_node xref: http://linkedlifedata.com/resource/umls/id/C0729596 xref: http://www.snomedbrowser.com/Codes/Details/181762005 xref: MA:0000737 xref: NCIT:C32801 xref: UMLS:C0729596 {source="ncithesaurus:Inguinal_Lymph_Node"} is_a: UBERON:0003968 {source="CL:tm"} ! peripheral lymph node [Term] id: UBERON:0001543 name: popliteal lymph node namespace: uberon def: "the lymph nodes which drain the legs; contained in the popliteal fossa" [http://en.wikipedia.org/wiki/Popliteal_lymph_node, MGI:cwg, MP:0002352] subset: pheno_slim subset: uberon_slim synonym: "popliteal glands" RELATED [http://en.wikipedia.org/wiki/Popliteal_lymph_nodes] synonym: "popliteal lymph glands" RELATED [http://en.wikipedia.org/wiki/Popliteal_lymph_nodes] synonym: "popliteal lymph node" RELATED [http://en.wikipedia.org/wiki/Popliteal_lymph_nodes] xref: FMA:44227 xref: http://en.wikipedia.org/wiki/Popliteal_lymph_node xref: http://linkedlifedata.com/resource/umls/id/C0588057 xref: http://www.snomedbrowser.com/Codes/Details/279156002 xref: MA:0000738 xref: NCIT:C53146 xref: UMLS:C0588057 {source="ncithesaurus:Popliteal_Lymph_Node"} is_a: UBERON:0003968 {source="CL:tm"} ! peripheral lymph node is_a: UBERON:0016398 ! lymph node of lower limb property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/66/Gray609.png xsd:anyURI property_value: UBPROP:0000001 "In the popliteal fossa between biceps femoris m. and semitendinosus m.." xsd:string {source="http://www.ncbi.nlm.nih.gov/pubmed/16624319", taxon="NCBITaxon:10090"} [Term] id: UBERON:0001631 name: thoracic duct namespace: uberon def: "A major lymphatic vessel that drains lymph from the lower body, left appendage, and left thorax into the junction of the left jugular and subclavian veins." [http://en.wikipedia.org/wiki/Thoracic_duct] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "ductus thoracicus" RELATED LATIN [http://en.wikipedia.org/wiki/Thoracic_duct] synonym: "trunk of thoracic duct tree" EXACT [] xref: EHDAA2:0004501 xref: EMAPA:19310 xref: FMA:5031 xref: GAID:1290 xref: http://linkedlifedata.com/resource/umls/id/C0039979 xref: http://www.snomedbrowser.com/Codes/Details/362600004 xref: MA:0002801 xref: MESH:A15.382.520.869 xref: NCIT:C33768 xref: TAO:0005110 xref: Thoracic:duct xref: UMLS:C0039979 {source="ncithesaurus:Thoracic_Duct"} xref: ZFA:0005110 is_a: UBERON:0001473 ! lymphatic vessel property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/75/Gray599.png xsd:anyURI property_value: IAO:0000116 "placement of the ZFA class here is dubious" xsd:string property_value: UBPROP:0000001 "Lymphatic trunk that connects all tributaries of the thoracic duct tree to the trunk of the left brachiocephalic vein." xsd:string {source="FMA:5031"} property_value: UBPROP:0000001 "The thoracic duct is the first perfused lymphatic, located between the dorsal aorta and posterior cardinal vein." xsd:string {source="ZFA:0005110"} [Term] id: UBERON:0001732 name: pharyngeal tonsil namespace: uberon def: "the lymph tissue in the roof and posterior wall of the nasopharynx" [MGI:cwg, MP:0002384] subset: pheno_slim subset: uberon_slim synonym: "adenoid" EXACT [] synonym: "nasopharyngeal tonsil" EXACT [] synonym: "Rachenmandel" RELATED [BTO:0000777] synonym: "tonsil of Luschka" EXACT [] synonym: "tonsilla pharyngea" RELATED LATIN [http://en.wikipedia.org/wiki/Pharyngeal_tonsil] synonym: "tonsilla pharyngealis" EXACT LATIN [FMA:54970, FMA:TA] xref: BTO:0000777 xref: EV:0100054 xref: FMA:54970 xref: GAID:1288 xref: http://linkedlifedata.com/resource/umls/id/C0001428 xref: http://www.snomedbrowser.com/Codes/Details/181199001 xref: MA:0000774 xref: MESH:A15.382.520.604.084 xref: NCIT:C33318 xref: Pharyngeal:tonsil xref: UMLS:C0001428 {source="ncithesaurus:Pharyngeal_Tonsil"} is_a: UBERON:0002372 ! tonsil is_a: UBERON:0012330 {source="cjm"} ! nasal-associated lymphoid tissue property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/be/Gray994-adenoid.png xsd:anyURI [Term] id: UBERON:0001735 name: tonsillar ring namespace: uberon def: "the circular lymphoid tissue formed by the lingual, pharyngeal, and facial tonsils" [MGI:cwg, MP:0002379] subset: pheno_slim subset: uberon_slim synonym: "anulus lymphoideus pharyngis" EXACT LATIN [FMA:55070, FMA:TA] synonym: "oropharyngeal lymphoid tissue" EXACT [] synonym: "pharyngeal lymphatic ring" EXACT [] synonym: "pharyngeal lymphoid ring" EXACT [] synonym: "Waldeyer's ring" EXACT [] synonym: "Waldeyer's tonsillar ring" EXACT [] xref: FMA:55070 xref: http://linkedlifedata.com/resource/umls/id/C0459892 xref: http://www.snomedbrowser.com/Codes/Details/56411004 xref: MA:0000752 xref: NCIT:C73468 xref: UMLS:C0459892 {source="ncithesaurus:Waldeyers_Tonsillar_Ring"} xref: Waldeyer's:ring is_a: UBERON:0001962 ! gut-associated lymphoid tissue property_value: seeAlso FMA:79771 [Term] id: UBERON:0001744 name: lymphoid tissue namespace: uberon def: "Portion of connective tissue with various types of white blood cells enmeshed in it, most numerous being the lymphocytes[WP]." [http://en.wikipedia.org/wiki/Lymphoid_tissue] subset: pheno_slim subset: uberon_slim synonym: "lymphatic tissue" EXACT [] synonym: "lymphocytic tissue" EXACT [] xref: BTO:0000753 xref: CALOHA:TS-0584 xref: FMA:55220 xref: GAID:342 xref: galen:LymphoidTissue xref: http://linkedlifedata.com/resource/umls/id/C0024296 xref: http://www.snomedbrowser.com/Codes/Details/181768009 xref: Lymphoid:tissue xref: MA:0002436 xref: MESH:D008221 xref: NCIT:C13049 xref: UMLS:C0024296 {source="ncithesaurus:Lymphoid_Tissue"} relationship: part_of UBERON:0002465 ! lymphoid system property_value: RO:0002174 NCBITaxon:7776 {notes="lampreys lack organized lymphoid tissue", source="NCBIBook:NBK27108"} [Term] id: UBERON:0001745 name: secondary nodular lymphoid tissue namespace: uberon def: "A lymphoid follicle that contains a germinal center." [CL:tm] subset: uberon_slim synonym: "peripheral lymphoid tissue" EXACT [] synonym: "secondary lymphoid nodule" EXACT [] synonym: "secondary lymphoid tissue" EXACT [] xref: FMA:55224 xref: GAID:946 is_a: UBERON:0000444 ! lymphoid follicle property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/2f/Keimzentrum.jpg xsd:anyURI [Term] id: UBERON:0001959 name: white pulp of spleen namespace: uberon def: "the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith, MP:0002357] subset: pheno_slim subset: uberon_slim synonym: "noduli lymphoidei splenici" RELATED LATIN [http://en.wikipedia.org/wiki/White_pulp] synonym: "pulpa alba" EXACT LATIN [FMA:62805, FMA:TA] synonym: "spleen white pulp" EXACT [] synonym: "splenic white pulp" EXACT [] synonym: "white pulp" EXACT [] xref: CALOHA:TS-1264 xref: EMAPA:35809 xref: FMA:62805 xref: http://linkedlifedata.com/resource/umls/id/C0229686 xref: MA:0000762 xref: NCIT:C12993 xref: UMLS:C0229686 {source="ncithesaurus:Splenic_White_Pulp"} xref: White:pulp is_a: UBERON:1000023 ! spleen pulp property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1191.png xsd:anyURI property_value: UBPROP:0000009 "The white pulp contains T cells, B cells and accessory cells. The function of the white pulp is to mount an immunological response to antigens within the blood. The white pulp is present in the form of a periarteriolar lymphoid sheath. This sheath contains B cell follicles and T cells. At the edge of the T zone is a region known as the marginal zone where larger lymphocytes and antigen presenting dendritic cells are located. [Wikipedia:White_pulp]" xsd:string [Term] id: UBERON:0001960 name: periarterial lymphatic sheath namespace: uberon def: "The area of the spleen in which T cells surround the central arteriole" [MP:0002358] subset: pheno_slim synonym: "PALS" EXACT ABBREVIATION [MP:0002358] synonym: "periarterial lymphoid sheath" EXACT [] synonym: "periarteriolar sheath" EXACT [MP:0002358] synonym: "spleen periarteriolar lymphatic sheath" EXACT [] synonym: "splenic periarteriolar lymphoid sheath" RELATED [MP:0002358] synonym: "T cell domain of the splenic white pulp" EXACT [MP:0002358] xref: EMAPA:37750 {source="MA:th"} xref: FMA:62810 xref: MA:0000765 is_a: UBERON:0010393 ! T cell domain relationship: part_of UBERON:0001959 ! white pulp of spleen property_value: UBPROP:0000012 "FMA distinguishes periarterial (PALS) from periarteriolar (FMA:62806)" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0001961 name: mucosa-associated lymphoid tissue namespace: uberon def: "diffuse system of small concentrations of lymphoid tissue found in various sites of the body such as the gastrointestinal tract, thyroid, breast, lung, salivary glands, eye, and skin[WP]. Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes[GO]." [http://en.wikipedia.org/wiki/Mucosa-associated_lymphoid_tissue] subset: pheno_slim subset: uberon_slim synonym: "epithelio-lymphoid tissue" EXACT [FMA:62819] synonym: "MALT" EXACT [] synonym: "mucosa associated lymphatic tissue" EXACT [] synonym: "mucosa associated lymphoid tissue" EXACT [] synonym: "mucosa-associated lymphoid tissue" EXACT [GO:0048537] synonym: "mucosal-associated lymphatic tissue" EXACT [GO:0048537] synonym: "mucosal-associated lymphoid tissue" EXACT [GO:0048537] xref: FMA:62819 xref: http://en.wikipedia.org/wiki/Mucosa-associated_lymphoid_tissue xref: http://linkedlifedata.com/resource/umls/id/C0599921 xref: MA:0000140 xref: NCIT:C12910 xref: UMLS:C0599921 {source="ncithesaurus:Mucosa-Associated_Lymphoid_Tissue"} is_a: UBERON:0012069 {source="FMA"} ! epithelium-associated lymphoid tissue property_value: IAO:0000116 "todo - add part relationships to specific layers" xsd:string [Term] id: UBERON:0001962 name: gut-associated lymphoid tissue namespace: uberon def: "Mucosa-associated lymphoid tissue in digestive tract. includes Peyer's patches, appendix, and solitary lymph nodules[GO]." [http://en.wikipedia.org/wiki/Gut-associated_lymphoid_tissue] subset: pheno_slim subset: uberon_slim synonym: "GALT" RELATED [] synonym: "gut associated lymphoid tissue" EXACT [] xref: FMA:62820 xref: http://en.wikipedia.org/wiki/Gut-associated_lymphoid_tissue xref: http://linkedlifedata.com/resource/umls/id/C0596638 xref: MA:0000136 xref: NCIT:C12936 xref: UMLS:C0596638 {source="ncithesaurus:Gut_Associated_Lymphoid_Tissue"} is_a: UBERON:0001961 ! mucosa-associated lymphoid tissue property_value: IAO:0000116 "phylogenetic relationships to be added" xsd:string property_value: UBPROP:0000008 "guts of jawless fish contains cells with lymphocyte-like morphology (Mayer 2002)." xsd:string [Term] id: UBERON:0001963 name: bronchial-associated lymphoid tissue namespace: uberon def: "A diffuse collection of lymphpoid cells that participate in airway immune responses" [ISBN:0123813611] comment: Lymphoid tissue associated with airways in mice has functional similarities to human BALT[ISBN:0123813611] Notes: FMA classifies this as organized, not diffuse subset: pheno_slim synonym: "BALT" RELATED [] synonym: "bronchus associated lymphoid tissue" EXACT [] xref: FMA:62821 xref: http://linkedlifedata.com/resource/umls/id/C1179418 xref: MA:0000135 xref: NCIT:C32234 xref: UMLS:C1179418 {source="ncithesaurus:Bronchus-Associated_Lymphoid_Tissue"} is_a: UBERON:0001961 ! mucosa-associated lymphoid tissue [Term] id: UBERON:0002006 name: cortex of lymph node namespace: uberon def: "Peripheral portion of the lymph node, underneath the capsule[WP]." [http://en.wikipedia.org/wiki/Cortex_of_lymph_node] subset: pheno_slim subset: uberon_slim synonym: "cortex nodi lymphoidei" RELATED LATIN [http://en.wikipedia.org/wiki/Cortex_of_lymph_node] synonym: "lymph node cortex" EXACT [] xref: EMAPA:35525 xref: FMA:66253 xref: http://en.wikipedia.org/wiki/Cortex_of_lymph_node xref: http://linkedlifedata.com/resource/umls/id/C0933402 xref: MA:0000740 xref: NCIT:C33029 xref: UMLS:C0933402 {source="ncithesaurus:Lymph_Node_Cortex"} relationship: part_of UBERON:0000029 ! lymph node property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b8/Illu_lymph_node_structure.png xsd:anyURI [Term] id: UBERON:0002007 name: medulla of lymph node namespace: uberon def: "The mdeullary portion of the lymph node, which contains large blood vessels, sinuses and medullary cords that contain antibody-secreting plasma cells." [http://en.wikipedia.org/wiki/Lymph_node#Medulla, http://orcid.org/0000-0002-6601-2165] subset: pheno_slim subset: uberon_slim synonym: "lymph node medulla" EXACT [] synonym: "medulla nodi lymphoidei" RELATED LATIN [http://en.wikipedia.org/wiki/Medulla_of_lymph_node] xref: EMAPA:35529 xref: FMA:66254 xref: MA:0000745 relationship: part_of UBERON:0000029 ! lymph node [Term] id: UBERON:0002042 name: lymphatic vessel endothelium namespace: uberon def: "An endothelium that is part of a lymphatic vessel [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim subset: vertebrate_core synonym: "endothelium of lymph vessel" EXACT [OBOL:automatic] synonym: "endothelium of lymphatic vessel" EXACT [FMA:68444] synonym: "lymph vessel endothelium" EXACT [OBOL:automatic] synonym: "lymphatic endothelium" EXACT [BTO:0004303] synonym: "lymphatic vessel endothelium" EXACT [] xref: BTO:0004303 xref: CALOHA:TS-2156 xref: EMAPA:35533 xref: FMA:68444 xref: http://linkedlifedata.com/resource/umls/id/C1180786 xref: MA:0000750 xref: MESH:D004729 xref: NCIT:C49258 xref: TAO:0005258 xref: UMLS:C1180786 {source="ncithesaurus:Lymphatic_Vessel_Endothelium"} xref: ZFA:0005258 relationship: part_of UBERON:0001473 ! lymphatic vessel property_value: UBPROP:0000001 "The vascular endothelium that lines the lymph vessels.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005258", ontology="TAO", source="ZFIN:curator"} [Term] id: UBERON:0002106 name: spleen namespace: uberon def: "the organ that functions to filter blood and to store red corpuscles and platelets" [ISBN:0-683-40008-8, MP:0000689] subset: efo_slim subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "lien" RELATED LATIN [http://en.wikipedia.org/wiki/Spleen] xref: AAO:0010395 xref: BTO:0001281 xref: CALOHA:TS-0956 xref: EFO:0000869 xref: EMAPA:18767 xref: EV:0100055 xref: FMA:7196 xref: GAID:1289 xref: galen:Spleen xref: http://en.wikipedia.org/wiki/Spleen xref: http://linkedlifedata.com/resource/umls/id/C0037993 xref: http://www.snomedbrowser.com/Codes/Details/181279003 xref: MA:0000141 xref: MAT:0000085 xref: MESH:A15.382.520.604.713 xref: MIAA:0000085 xref: NCIT:C12432 xref: OpenCyc:Mx4rvVjgw5wpEbGdrcN5Y29ycA xref: TAO:0000436 xref: UMLS:C0037993 {source="ncithesaurus:Spleen"} xref: VHOG:0000120 xref: XAO:0000328 xref: ZFA:0000436 is_a: UBERON:0005057 ! immune organ property_value: depicted:by Illu:spleen.jpg xsd:anyURI property_value: UBPROP:0000001 "An organ involved in red blood cell filtration and immune response.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010395", ontology="AAO", source="AAO:BMZ"} property_value: UBPROP:0000003 "With the advent of clonal selection, the accumulation and segregation of T and B cells in specialized organs for antigen presentation became necessary, and indeed the spleen is found in all jawed vertebrates, but not in agnathans or invertebrates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000120", ontology="VHOG", source="http://bgee.unil.ch/", source="ISBN:978-0781765190 Paul WE, Fundamental Immunology (2008) p.94"} property_value: UBPROP:0000007 "lienal" xsd:string property_value: UBPROP:0000007 "splenic" xsd:string property_value: UBPROP:0000008 "In humans, it is located in the left upper quadrant of the abdomen. It removes old red blood cells and holds a reserve in case of hemorrhagic shock, especially in animals like horses (not in humans), while recycling iron" xsd:string property_value: UBPROP:0000008 "Neither hagfish nor lampreys possess what might be considered a discrete and condensed spleen. Hagfish possess dispersed lymphoid tissue within the submucosa of the intestine (96) associated with the portal vein (97), whereas lymphoid tissue is associated with the typhlosole portion of the intestine in lampreys (96)" xsd:string {source="http://www.ncbi.nlm.nih.gov/pubmed/20959416"} property_value: UBPROP:0000009 "It synthesizes antibodies in its white pulp and removes, from blood and lymph node circulation, antibody-coated bacteria along with antibody-coated blood cells" xsd:string [Term] id: UBERON:0002122 name: capsule of thymus namespace: uberon def: "The fibrous connective tissue surrounding the thymus." [MP:0002368] subset: pheno_slim synonym: "thymic capsule" EXACT [] synonym: "thymus capsule" EXACT [] xref: EMAPA:19306 xref: FMA:72204 xref: http://linkedlifedata.com/resource/umls/id/C0229945 xref: http://www.snomedbrowser.com/Codes/Details/188181003 xref: MA:0000766 xref: NCIT:C33770 xref: UMLS:C0229945 {source="ncithesaurus:Thymic_Capsule"} relationship: part_of UBERON:0002370 ! thymus [Term] id: UBERON:0002123 name: cortex of thymus namespace: uberon def: "the outer part of a thymus lobule that surrounds the medulla and is composed of closely packed lymphocytes" [ISBN:0-683-40008-8, MP:0002371] subset: pheno_slim synonym: "thymic cortex" EXACT [BTO:0002934] synonym: "thymus cortex" EXACT [MA:0000767] xref: BTO:0002934 xref: Cortex xref: EMAPA:35863 xref: FMA:72205 xref: http://linkedlifedata.com/resource/umls/id/C0229948 xref: http://www.snomedbrowser.com/Codes/Details/188262003 xref: MA:0000767 xref: NCIT:C33774 xref: UMLS:C0229948 {source="ncithesaurus:Thymus_Cortex"} relationship: part_of UBERON:0002370 ! thymus property_value: RO:0002175 NCBITaxon:7955 {source="https://doi.org/10.1177/0192623311409597"} property_value: UBPROP:0000010 "Histologically, the thymus can be divided into a central medulla and a peripheral cortex which is surrounded by an outer capsule. The cortex and medulla play different roles in the development of T cells. Cells in the thymus can be divided into thymic stromal cells and cells of hematopoietic origin[WP]" xsd:string [Term] id: UBERON:0002124 name: medulla of thymus namespace: uberon def: "Medullary portion of thymus. The reticulum is coarser than in the cortex, the lymphoid cells are relatively fewer in number, and there are found peculiar nest-like bodies, the concentric corpuscles of Hassall. These concentric corpuscles are composed of a central mass, consisting of one or more granular cells, and of a capsule formed of epithelioid cells. They are the remains of the epithelial tubes, which grow out from the third branchial pouches of the embryo to form the thymus. Each follicle is surrounded by a vascular plexus, from which vessels pass into the interior, and radiate from the periphery toward the center, forming a second zone just within the margin of the medullary portion. In the center of the medullary portion there are very few vessels, and they are of minute size." [http://en.wikipedia.org/wiki/Thymus#Medulla] subset: efo_slim subset: pheno_slim synonym: "medulla of thymus gland" EXACT [OBOL:automatic] synonym: "thymus gland medulla" EXACT [OBOL:automatic] synonym: "thymus medulla" EXACT [] xref: BTO:0004560 xref: EFO:0001969 xref: EMAPA:19305 xref: FMA:72206 xref: http://linkedlifedata.com/resource/umls/id/C0229949 xref: http://www.snomedbrowser.com/Codes/Details/188344009 xref: MA:0000771 xref: Medulla xref: NCIT:C33775 xref: UMLS:C0229949 {source="ncithesaurus:Thymus_Medulla"} relationship: part_of UBERON:0002370 ! thymus property_value: RO:0002175 NCBITaxon:7955 {source="https://doi.org/10.1177/0192623311409597"} [Term] id: UBERON:0002125 name: thymus lobule namespace: uberon def: "A lobule that is part of a thymus. Divided into an outer cortex and inner medulla and separated from each other by connective tissue septa, but with the medullary tissue continuous from lobule to lobule.[ncit,modified]." [http://orcid.org/0000-0002-6601-2165, ncithesaurus:Thymic_Lobule] subset: pheno_slim synonym: "lobule of thymus" EXACT [FMA:72215] synonym: "thymic lobule" EXACT [] synonym: "thymus lobule" EXACT [MA:0000770] xref: FMA:72215 xref: http://linkedlifedata.com/resource/umls/id/C1522462 xref: http://www.snomedbrowser.com/Codes/Details/187882006 xref: MA:0000770 xref: NCIT:C33772 xref: UMLS:C1522462 {source="ncithesaurus:Thymic_Lobule"} relationship: part_of UBERON:0002370 ! thymus property_value: UBPROP:0000008 "in the mouse, the lobes of the thymus are not subdivided into lobules but only in the central medulla and a peripheral cortex (i.e. there is no distinct sublobulation). In humans, the two thymus lobes are composed of many lobules of various sizes which contain follicles, each comprising a medulla and a cortex. in the rat, the thymus is partially subdivided into lobules separated by thin bands of connective tissue which are continuous with the thin connective tissue capsule.[MP]" xsd:string property_value: UBPROP:0000010 "Lymphocytes, reticular cells and macrophages are found in the lobules" xsd:string [Term] id: UBERON:0002194 name: capsule of lymph node namespace: uberon def: "Capsule surrounding lymph node composed of connective tissue with some plain muscle fibers." [http://en.wikipedia.org/wiki/Lymph_node#Capsule] subset: uberon_slim synonym: "capsula nodi lymphoidei" EXACT LATIN [FMA:74604, FMA:TA] synonym: "lymph node capsule" EXACT [] xref: EMAPA:35524 xref: FMA:74604 xref: http://en.wikipedia.org/wiki/Lymph_node_capsule xref: http://linkedlifedata.com/resource/umls/id/C0229699 xref: http://www.snomedbrowser.com/Codes/Details/327532004 xref: MA:0000739 xref: NCIT:C33028 xref: UMLS:C0229699 {source="ncithesaurus:Lymph_Node_Capsule"} relationship: part_of UBERON:0000029 ! lymph node property_value: depicted:by Lymphknoten:(Schwein).jpg xsd:anyURI property_value: UBPROP:0000008 "from its internal surface are given off a number of membranous processes or trabeculae, consisting, in man, of connective tissue, with a small admixture of plain muscle fibers; but in many of the lower animals composed almost entirely of involuntary muscle[WP]" xsd:string [Term] id: UBERON:0002195 name: trabecula of lymph node namespace: uberon def: "Membranous process coming from capsule of lymph node[WP]." [http://en.wikipedia.org/wiki/Lymph_node_trabeculae] subset: pheno_slim synonym: "lymph node trabecula" EXACT [] synonym: "lymph node trabeculum" EXACT [] xref: FMA:74605 xref: http://en.wikipedia.org/wiki/Lymph_node_trabeculae xref: http://linkedlifedata.com/resource/umls/id/C1184179 xref: MA:0000746 xref: NCIT:C33035 xref: UMLS:C1184179 {source="ncithesaurus:Lymph_Node_Trabecula"} relationship: part_of UBERON:0000029 ! lymph node property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b3/Gray598.png xsd:anyURI [Term] id: UBERON:0002370 name: thymus namespace: uberon def: "Anatomical structure of largely lymphoid tissue that functions in cell-mediated immunity by being the site where T cells develop." [http://en.wikipedia.org/wiki/Thymus, NLM:thymus] subset: efo_slim subset: major_organ subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "thymus gland" EXACT [] synonym: "thymus organ" EXACT [] xref: AAO:0010548 xref: BTO:0001374 xref: CALOHA:TS-1043 xref: EFO:0000860 xref: EHDAA2:0002017 xref: EHDAA:9119 xref: EMAPA:18768 xref: EV:0100138 xref: FMA:9607 xref: GAID:464 xref: http://en.wikipedia.org/wiki/Thymus xref: http://linkedlifedata.com/resource/umls/id/C0040113 xref: http://www.snomedbrowser.com/Codes/Details/118507000 xref: MA:0000142 xref: MAT:0000080 xref: MESH:A06.407.850 xref: MIAA:0000080 xref: NCIT:C12433 xref: OpenCyc:Mx4rvpIympwpEbGdrcN5Y29ycA xref: TAO:0001078 xref: UMLS:C0040113 {source="ncithesaurus:Thymus_Gland"} xref: VHOG:0000253 xref: XAO:0000163 xref: ZFA:0001078 is_a: UBERON:0005057 ! immune organ property_value: depicted:by Illu:thymus.jpg xsd:anyURI property_value: IAO:0000116 "check - a subtype of gland? not in GO. NCIT has thymus and thymus gland. EHDAA2 has ductless gland." xsd:string property_value: UBPROP:0000001 "Anatomical structure which originates as several paired thickenings on the dorsal side of the pharyngeal pouches and secretes thymosin.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010548", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000003 "A thymus develops in all vertebrates from the endodermal epithelium of certain pharyngeal pouches and from the adjacent ectodermal epithelium. In fishes, all the pouches, or the first four, contribute to thymus formation, but in tetrapods, the number is more restricted. In mammals, only the third and fourth are involved, and the contribution of the third is by far the greater.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000253", ontology="VHOG", source="http://bgee.unil.ch/", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) p.558"} property_value: UBPROP:0000007 "thymic" xsd:string [Term] id: UBERON:0002371 name: bone marrow namespace: uberon def: "the soft tissue that fills the cavities of bones" [MGI:cwg, MP:0002397] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "medulla of bone" RELATED [BTO:0000141] synonym: "medulla ossea" EXACT LATIN [BTO:0000141, FMA:9608] synonym: "medulla ossium" EXACT LATIN [BTO:0000141, http://en.wikipedia.org/wiki/Bone_marrow] synonym: "medullary bone" RELATED [] xref: AAO:0011007 xref: Bone:marrow xref: BTO:0000141 xref: BTO:0000829 xref: CALOHA:TS-0087 xref: EFO:0000868 xref: EMAPA:32760 xref: EV:0100046 xref: FMA:9608 xref: GAID:1287 xref: galen:BoneMarrow xref: http://linkedlifedata.com/resource/umls/id/C0005953 xref: http://www.snomedbrowser.com/Codes/Details/421320006 xref: MA:0000134 xref: MAT:0000084 xref: MESH:D001853 xref: MIAA:0000084 xref: NCIT:C12431 xref: OpenCyc:Mx4rvVm-FpwpEbGdrcN5Y29ycA xref: UMLS:C0005953 {source="ncithesaurus:Bone_Marrow"} xref: VHOG:0001218 xref: XAO:0000123 relationship: part_of UBERON:0002405 ! immune system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/74/Gray72-en.svg xsd:anyURI property_value: IAO:0000116 "consider placement of NCIT:C53466 medullary bone" xsd:string property_value: IAO:0000116 "TODO - create superclass for bone marrow / head kidney. both are portions of tissue in the hematopoetic system. also consider adding as subclass of zone of bone organ for consistency with FMA. See also: Leydig and epigonal organs" xsd:string property_value: UBPROP:0000003 "The bone marrow is the hematopoietic organ in all vertebrates but fishes, in which hematopoiesis occurs in the kidney.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001218", ontology="VHOG", source="http://bgee.unil.ch/", source="DOI:10.1146/annurev.cellbio.22.010605.093317 Hartenstein V, Blood Cells and Blood Cell Development in the Animal Kingdom. Annual Review of Cell and Developmental Biology (2006)"} property_value: UBPROP:0000009 "In adults, marrow in large bones produces new blood cells[Wikipedia:Bone_marrow]" xsd:string [Term] id: UBERON:0002372 name: tonsil namespace: uberon def: "either of the two small almond-shaped masses of lymph tissue found on either side of the oropharynx" [MGI:cwg, MP:0002380] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "Mandel" RELATED [BTO:0001387] xref: BTO:0001387 xref: CALOHA:TS-1053 xref: EFO:0001401 xref: EMAPA:35871 xref: EV:0100052 xref: FMA:9609 xref: GAID:341 xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=671 xref: http://en.wikipedia.org/wiki/Tonsil xref: http://linkedlifedata.com/resource/umls/id/C0836921 xref: http://linkedlifedata.com/resource/umls/id/C1519547 xref: http://linkedlifedata.com/resource/umls/id/C1519548 xref: MA:0000143 xref: MESH:A03.867.603.925 xref: NCIT:C12802 xref: OpenCyc:Mx4rvVivrZwpEbGdrcN5Y29ycA xref: UMLS:C0836921 {source="ncithesaurus:Tonsil"} xref: UMLS:C1519547 {source="ncithesaurus:Tonsilar_Tissue"} xref: UMLS:C1519548 {source="ncithesaurus:Tonsillar_Lymphoid_Tissue"} xref: VHOG:0001139 is_a: UBERON:0001962 ! gut-associated lymphoid tissue relationship: part_of UBERON:0001735 {source="cjm"} ! tonsillar ring property_value: IAO:0000232 "the term 'tonsil' can be ambiguous, sometimes refering specifically to the palatine tonsil, sometimes generically to include the cecal tonsils of avians. This class represents lymphoid tissue that is part of the tonsillar ring, in the mouth/throat region" xsd:string [Term] id: UBERON:0002373 name: palatine tonsil namespace: uberon def: "tonsils on the left and right sides at the back of the throat. one of the mucosa-associated lymphoid tissues (MALT), located at the entrance to the upper respiratory and gastrointestinal tracts to protect the body from the entry of exogenous material through mucosal sites[WP]." [http://en.wikipedia.org/wiki/Palatine_tonsil] subset: efo_slim subset: uberon_slim synonym: "faucial tonsil" EXACT [] synonym: "Gaumenmandel@de" RELATED [BTO:0004714] synonym: "tonsil" BROAD [] synonym: "tonsilla palatina" RELATED LATIN [http://en.wikipedia.org/wiki/Palatine_tonsil] xref: BTO:0004714 xref: EFO:0001977 xref: EMAPA:35644 xref: EV:0100393 xref: FMA:9610 xref: http://linkedlifedata.com/resource/umls/id/C0040421 xref: http://www.snomedbrowser.com/Codes/Details/265787001 xref: MA:0000775 xref: MAT:0000291 xref: MIAA:0000291 xref: NCIT:C33250 xref: Palatine:tonsil xref: UMLS:C0040421 {source="ncithesaurus:Palatine_Tonsil"} xref: VHOG:0001140 is_a: UBERON:0002372 ! tonsil property_value: depicted:by Illu:mouth.jpg xsd:anyURI property_value: RO:0002174 NCBITaxon:9989 {source="http://www.ncbi.nlm.nih.gov/pubmed/20144910"} property_value: UBPROP:0000011 "tonsillar fossa develops from dorsal portion of pouch 2. Note that pharyngeal and lingual tonsils do not develop from pharyngeal pouches" xsd:string {source="ISBN:1607950324"} [Term] id: UBERON:0002391 name: lymph namespace: uberon def: "Lymph is the fluid that is formed when interstitial fluid enters the conduits of the lymphatic system through lymph capillaries[WP]." [http://en.wikipedia.org/wiki/Lymph] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "lympha" RELATED LATIN [http://en.wikipedia.org/wiki/Lymph] xref: BTO:0000855 xref: CALOHA:TS-0580 xref: EFO:0000871 xref: ENVO:02000041 xref: EV:0100049 xref: FMA:9671 xref: GAID:1186 xref: galen:Lymph xref: http://en.wikipedia.org/wiki/Lymph xref: http://linkedlifedata.com/resource/umls/id/C0024202 xref: MA:0002520 xref: MAT:0000055 xref: MESH:A12.207.630 xref: MIAA:0000055 xref: NCIT:C13252 xref: OpenCyc:Mx4rvpDOU5wpEbGdrcN5Y29ycA xref: UMLS:C0024202 {source="ncithesaurus:Lymph"} xref: VHOG:0001590 xref: ZFA:0005658 relationship: part_of UBERON:0006558 ! lymphatic part of lymphoid system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/19/Illu_lymph_capillary.png xsd:anyURI [Term] id: UBERON:0002405 name: immune system namespace: uberon def: "Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies." [http://en.wikipedia.org/wiki/Immune_system] subset: pheno_slim subset: uberon_slim subset: vertebrate_core xref: AAO:0011003 xref: BILA:0000104 xref: BTO:0005810 xref: FMA:9825 xref: GAID:328 xref: http://linkedlifedata.com/resource/umls/id/C0020962 xref: http://www.snomedbrowser.com/Codes/Details/362590003 xref: Immune:system xref: MA:0002711 xref: MESH:D007107 xref: NCIT:C12735 xref: OpenCyc:Mx4rvWNkm5wpEbGdrcN5Y29ycA xref: TAO:0001159 xref: UMLS:C0020962 {source="ncithesaurus:Immune_System"} xref: VHOG:0001247 xref: XAO:0003152 xref: ZFA:0001159 is_a: UBERON:0000467 ! anatomical system property_value: UBPROP:0000003 "The antibody-based immune system defined by the presence of the major histocompatibility complex (MHC), T cell receptor (TCR), B cell receptor (BCR) or recombination activating genes (RAGs) is known beginning from jawed fishes.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001247", ontology="VHOG", source="http://bgee.unil.ch/", source="PMID:21046016 Dzik JM, The ancestry and cumulative evolution of immune reactions. Acta biochimica Polonica (2010)"} [Term] id: UBERON:0002429 name: cervical lymph node namespace: uberon def: "Cervical lymph nodes are lymph nodes found in the neck. [WP,unvetted]." [http://en.wikipedia.org/wiki/Cervical_lymph_node] subset: pheno_slim subset: uberon_slim synonym: "lymph node of neck" EXACT [] xref: FMA:61213 xref: http://en.wikipedia.org/wiki/Cervical_lymph_nodes xref: http://linkedlifedata.com/resource/umls/id/C0588054 xref: http://www.snomedbrowser.com/Codes/Details/181757009 xref: MA:0000736 xref: NCIT:C32298 xref: UMLS:C0588054 {source="ncithesaurus:Cervical_Lymph_Node"} is_a: UBERON:0000029 ! lymph node property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/4/4c/Lymph_node_regions.jpg xsd:anyURI [Term] id: UBERON:0002465 name: lymphoid system namespace: uberon alt_id: UBERON:0002096 def: "The lymphatic system in vertebrates is a network of conduits that carry a clear fluid called lymph. It also includes the lymphoid tissue through which the lymph travels. Lymphoid tissue is found in many organs, particularly the lymph nodes, and in the lymphoid follicles associated with the digestive system such as the tonsils. The system also includes all the structures dedicated to the circulation and production of lymphocytes, which includes the spleen, thymus, bone marrow and the lymphoid tissue associated with the digestive system[WP]." [http://en.wikipedia.org/wiki/Lymphoid_system] subset: uberon_slim subset: vertebrate_core synonym: "lymphatic circulatory system" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "lymphatic drainage system" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "lymphatic system" NARROW [ZFA:0000385] synonym: "systema lymphoideum" RELATED LATIN [http://en.wikipedia.org/wiki/Lymphoid_system] xref: EHDAA2:0001043 xref: EHDAA:8677 xref: EMAPA:37664 {source="MA:th"} xref: FMA:74594 xref: GAID:931 xref: http://linkedlifedata.com/resource/umls/id/C0024235 xref: http://www.snomedbrowser.com/Codes/Details/362589007 xref: Lymphoid:system xref: MA:0002435 xref: MAT:0000197 xref: MIAA:0000197 xref: NCIT:C12746 xref: OpenCyc:Mx4rwQAKT5wpEbGdrcN5Y29ycA xref: TAO:0000385 xref: UMLS:C0024235 {source="ncithesaurus:Lymphatic_System"} xref: VHOG:0000842 xref: XAO:0003199 xref: ZFA:0000385 is_a: UBERON:0000467 ! anatomical system relationship: part_of UBERON:0002405 ! immune system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b3/TE-Lymphatic_system_diagram.svg xsd:anyURI property_value: UBPROP:0000001 "Part of the circulatory system which consists of a series of vessels which collect blood (exclusive of erythrocytes) which seep through capillary walls and return it to the veins.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010522", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000003 "Tetrapods have evolved distinct lymphatic systems, in which lymphatic capillaries help drain most of the tissues of the body.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000842", ontology="VHOG", source="http://bgee.unil.ch/", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.627"} property_value: UBPROP:0000007 "lymphoid" xsd:string property_value: UBPROP:0000008 "The lymphatic system of anuran amphibians is characterized by large lymphatic sacs and two pairs of lymph hearts that return lymph into the venous circulation but no lymph vessels per se [10.1152/japplphysiol.00201.2013]" xsd:string property_value: UBPROP:0000008 "The lymphatic systems of reptiles and some birds have lymph hearts, and both groups have extensive lymph vessels, but their functional role in both lymph movement and plasma volume homeostasis is almost completely unknown [10.1152/japplphysiol.00201.2013]" xsd:string property_value: UBPROP:0000012 "We follow FMA and MA in distinguishing between lymphatic system and lymphoid system, with lymhoid tissue part of the non-lymphatic component, although these terms are often used interchangeably. We assume the ZFA term lymphatic tissue actually corresponds to the broader class (e.g. ZFA lymph node in the ZFA lymphatic system). See tracker for more comments." xsd:string {source="https://github.com/obophenotype/mouse-anatomy-ontology/issues/51"} [Term] id: UBERON:0002507 name: abdominal lymph node namespace: uberon def: "A lymph node that is part of an abdomen [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "abdomen lymph node" EXACT [OBOL:automatic] synonym: "lymph node of abdomen" EXACT [] synonym: "parietal abdominal lymph node" RELATED [FMA:12787] xref: EMAPA:35992 xref: FMA:12787 xref: http://www.snomedbrowser.com/Codes/Details/245342005 xref: MA:0002827 is_a: UBERON:0000029 ! lymph node [Term] id: UBERON:0002508 name: celiac lymph node namespace: uberon def: "the visceral glands that are associated with the branches of the celiac artery, including the gastric, hepatic, and pancreaticolienal (splenic) lymph nodes" [MGI:csmith, MP:0009626] subset: pheno_slim subset: uberon_slim synonym: "aJCC level 20 node" RELATED [FMA:12792] synonym: "celiac node" EXACT [] synonym: "coeliac lymph node" RELATED [FMA:12792] synonym: "coeliac node" EXACT [] synonym: "jPS 9 node" RELATED [FMA:12792] synonym: "jPS no. 9 node" RELATED [FMA:12792] synonym: "no. 9 celiac lymph node" RELATED [FMA:12792] synonym: "nodus lymphaticus coeliacus" EXACT [] synonym: "terminal ventral aortic node" EXACT [] xref: FMA:12792 xref: http://en.wikipedia.org/wiki/Celiac_lymph_node xref: http://linkedlifedata.com/resource/umls/id/C0229766 xref: http://www.snomedbrowser.com/Codes/Details/245343000 xref: MA:0002828 xref: NCIT:C65166 xref: UMLS:C0229766 {source="ncithesaurus:Celiac_Lymph_Node"} is_a: UBERON:0015860 {source="FMA"} ! visceral abdominal lymph node property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/71/Gray613.png xsd:anyURI [Term] id: UBERON:0002509 name: mesenteric lymph node namespace: uberon def: "The lymph nodes located in the mesentery, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group." [MP:0005232] subset: pheno_slim synonym: "mesenteric node" EXACT [] synonym: "nodi lymphoidei mesenterici" RELATED LATIN [BTO:0000767] xref: BTO:0000767 xref: EMAPA:35561 xref: FMA:12795 xref: http://en.wikipedia.org/wiki/Mesenteric_lymph_nodes xref: http://linkedlifedata.com/resource/umls/id/C0229792 xref: MA:0002829 xref: NCIT:C77641 xref: UMLS:C0229792 {source="ncithesaurus:Mesenteric_Lymph_Node"} is_a: UBERON:0015860 {source="FMA"} ! visceral abdominal lymph node [Term] id: UBERON:0002520 name: submandibular lymph node namespace: uberon def: "The submandibular lymph nodes (submaxillary glands in older texts), three to six in number, are placed beneath the body of the mandible in the submaxillary triangle, and rest on the superficial surface of the submaxillary salivary gland. One gland, the middle gland of Stahr, which lies on the external maxillary artery as it turns over the mandible, is the most constant of the series; small lymph glands are sometimes found on the deep surface of the submaxillary salivary glands. The afferents of the submaxillary glands drain the medial palpebral commissure, the cheek, the side of the nose, the upper lip, the lateral part of the lower lip, the gums, and the anterior part of the margin of the tongue. Efferent vessels from the facial and submental glands also enter the submaxillary glands. Their efferent vessels pass to the superior deep cervical glands. [WP,unvetted]." [http://en.wikipedia.org/wiki/Submandibular_lymph_node] subset: pheno_slim subset: uberon_slim synonym: "mandibular lymph node" RELATED SENSU [] synonym: "nodi lymphoidei submandibulares" RELATED [BTO:0000769] synonym: "submandibular node" EXACT [] xref: BTO:0000769 xref: FMA:61224 xref: http://en.wikipedia.org/wiki/Submandibular_lymph_node xref: http://linkedlifedata.com/resource/umls/id/C0229722 xref: http://www.snomedbrowser.com/Codes/Details/245319003 xref: MA:0002843 xref: NCIT:C77650 xref: UMLS:C0229722 {source="ncithesaurus:Submandibular_Lymph_Node"} is_a: UBERON:0003968 {source="CL:tm"} ! peripheral lymph node property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/4/4e/Illu_quiz_hn_03.jpg xsd:anyURI [Term] id: UBERON:0002524 name: mediastinal lymph node namespace: uberon def: "A lymph node that is part of a mediastinum. Each consists of several lymph node groups, especially along the trachea (5 groups), along the esophagus and between the lung and the diaphragm. In the mediastinal lymph nodes arises lymphatic ducts, which draines the lymph to the left subclavian vein (to the venous angle in the confluence of the subclavian and deep jugular veins). The mediastinal lymph nodes along the esophagus are in tight connection with the abdominal lymph nodes along the esophagus and the stomach. That fact facilitates spreading of tumors cells through these lymphatics in cases of cancers of the stomach and particularly of the esophagus. Through the mediastinum, the main lymphatic drainage from the abdominal organs goes via the thoracic duct (ductus thoracicus), which drains majority of the lymph from the abdomen to the above mentioned left venous angle." [http://en.wikipedia.org/wiki/Lymph_node#Lymph_nodes_of_the_thorax, OBOL:automatic] subset: efo_slim synonym: "mediastinal node" EXACT [] xref: EFO:0001670 xref: EMAPA:35555 xref: FMA:12774 xref: http://linkedlifedata.com/resource/umls/id/C0588055 xref: http://www.snomedbrowser.com/Codes/Details/181760002 xref: Lymph_nodes_of_the_thorax xref: MA:0002877 xref: NCIT:C33073 xref: UMLS:C0588055 {source="ncithesaurus:Mediastinal_Lymph_Node"} is_a: UBERON:0007644 {source="FMA"} ! thoracic lymph node [Term] id: UBERON:0002525 name: brachial lymph node namespace: uberon def: "The lymph nodes located along the brachial vein that receive drainage from most of the free upper limb and send efferent vessels to the central axillary lymph nodes." [http://en.wikipedia.org/wiki/Brachial_lymph_nodes, MP:0005231] subset: pheno_slim synonym: "nodi lymphoidei brachiales" RELATED LATIN [http://en.wikipedia.org/wiki/Brachial_lymph_nodes] xref: FMA:44314 xref: http://en.wikipedia.org/wiki/Brachial_lymph_nodes xref: http://linkedlifedata.com/resource/umls/id/C0229840 xref: MA:0002878 xref: NCIT:C92221 xref: UMLS:C0229840 {source="ncithesaurus:Brachial_Lymph_Node"} is_a: UBERON:0000029 ! lymph node property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/73/Gray607.png xsd:anyURI [Term] id: UBERON:0002526 name: lumbar lymph node namespace: uberon def: "The lumbar lymph nodes (paraaortic nodes) are a group of lymph nodes residing in the lumbar region. They consist of the following groups: right and left lateral aortic lymph nodes preaortic lymph nodes retroaortic lymph nodes (or 'postaortic')" [http://en.wikipedia.org/wiki/Lumbar_lymph_nodes] synonym: "aortocaval lymph node" RELATED [FMA:84599] synonym: "aortocaval node" RELATED [FMA:84599] synonym: "area 16 lymph node" RELATED [FMA:84599] synonym: "jPS 16 node" RELATED [FMA:84599] synonym: "jPS no. 16 node" RELATED [FMA:84599] synonym: "lumbar glands" RELATED [http://en.wikipedia.org/wiki/Lumbar_lymph_nodes] synonym: "lumbo-aortic lymph node" RELATED [FMA:84599] synonym: "para-aortic lumbar lymph node" RELATED [FMA:84599] synonym: "parietal para-aortic lymph node" RELATED [FMA:84599] xref: FMA:84599 xref: http://en.wikipedia.org/wiki/Lumbar_lymph_nodes xref: http://www.snomedbrowser.com/Codes/Details/281412000 xref: MA:0002879 xref: NCIT:C118775 is_a: UBERON:0002507 ! abdominal lymph node [Term] id: UBERON:0002527 name: pancreatic lymph node namespace: uberon def: "A lymph node that is part of a pancreas [Automatically generated definition]." [OBOL:automatic] synonym: "aJCC level 19 node" RELATED [FMA:16626] synonym: "lymph node of pancreas" EXACT [OBOL:automatic] synonym: "pancreas lymph node" EXACT [OBOL:automatic] synonym: "pancreatic node" EXACT [] synonym: "pyloric lymph node" RELATED INCONSISTENT [MA:0002881] xref: FMA:16626 xref: http://linkedlifedata.com/resource/umls/id/C0229783 xref: http://www.snomedbrowser.com/Codes/Details/276170003 xref: MA:0002881 xref: NCIT:C77642 xref: UMLS:C0229783 {source="ncithesaurus:Pancreatic_Lymph_Node"} is_a: UBERON:0002507 ! abdominal lymph node [Term] id: UBERON:0002528 name: sacral lymph node namespace: uberon def: "A lymph node located in the sacral region." [ncithesaurus:Sacral_Lymph_Node] synonym: "sacral node" EXACT [] xref: FMA:16655 xref: http://en.wikipedia.org/wiki/Sacral_lymph_nodes xref: http://linkedlifedata.com/resource/umls/id/C0229827 xref: http://www.snomedbrowser.com/Codes/Details/279797001 xref: MA:0002883 xref: NCIT:C77647 xref: UMLS:C0229827 {source="ncithesaurus:Sacral_Lymph_Node"} is_a: UBERON:0000029 ! lymph node [Term] id: UBERON:0003425 name: renal lymph node namespace: uberon def: "A lymph node that is located in a kidney [Automatically generated definition]." [OBOL:automatic] synonym: "kidney lymph node" EXACT [OBOL:automatic] synonym: "lymph node of kidney" EXACT [OBOL:automatic] xref: FMA:276799 xref: http://linkedlifedata.com/resource/umls/id/C2699031 xref: MA:0002882 xref: NCIT:C77646 xref: UMLS:C2699031 {source="ncithesaurus:Renal_Lymph_Node"} is_a: UBERON:0000029 ! lymph node property_value: UBPROP:0000001 "Dorsal to the ipsilateral kidney nearby the renal blood vessels, caudal to the adrenal gland" xsd:string {source="http://www.ncbi.nlm.nih.gov/pubmed/16624319", taxon="NCBITaxon:10090"} [Term] id: UBERON:0003453 name: large intestine Peyer's patch namespace: uberon def: "A Peyer's patch that is part of a large intestine." [OBOL:automatic] synonym: "large intestine Peyer's patch" EXACT [OBOL:automatic] synonym: "Peyer's patch of large intestine" EXACT [OBOL:automatic] synonym: "solitary lymphatic follicle of large intestine" RELATED [FMA:15658] synonym: "solitary lymphoid follicle of subdivision of large intestine" RELATED [FMA:15658] xref: EMAPA:35468 xref: FMA:15658 xref: MA:0001550 is_a: UBERON:0001211 ! Peyer's patch property_value: IAO:0000116 "requires expert attention" xsd:string [Term] id: UBERON:0003454 name: small intestine Peyer's patch namespace: uberon def: "nodular lymphoid structures on the serosal surface of the small intestine." [http://orcid.org/0000-0002-6601-2165] synonym: "aggregated lymphoid follicle of small intestine" EXACT [FMA:15054] synonym: "noduli lymphoidei aggregati intestini tenuis" EXACT LATIN [FMA:76466] synonym: "Peyer's patch" BROAD [FMA:15054] synonym: "Peyer's patch of small bowel" EXACT [OBOL:automatic] synonym: "Peyer's patch of small intestine" EXACT [OBOL:automatic] synonym: "small bowel Peyer's patch" EXACT [OBOL:automatic] synonym: "small intestine Peyer's patch" EXACT [OBOL:automatic] xref: EMAPA:35782 xref: FMA:15054 xref: http://www.snomedbrowser.com/Codes/Details/38986009 xref: MA:0001557 is_a: UBERON:0001211 ! Peyer's patch property_value: IAO:0000116 "add subtypes for jejunum, ileum" xsd:string property_value: UBPROP:0000202 FMA:76466 [Term] id: UBERON:0003456 name: respiratory system lymphatic vessel namespace: uberon def: "A lymphatic vessel that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] synonym: "apparatus respiratorius lymph vessel" EXACT [OBOL:automatic] synonym: "apparatus respiratorius lymphatic vessel" EXACT [OBOL:automatic] synonym: "lymph vessel of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "lymph vessel of respiratory system" EXACT [OBOL:automatic] synonym: "lymphatic vessel of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "lymphatic vessel of respiratory system" EXACT [OBOL:automatic] synonym: "respiratory system lymph vessel" EXACT [OBOL:automatic] xref: EMAPA:37580 {source="MA:th"} xref: MA:0001824 is_a: UBERON:0001473 ! lymphatic vessel [Term] id: UBERON:0003483 name: thymus lymphoid tissue namespace: uberon def: "A portion of lymphoid tissue that is part of a thymus [Automatically generated definition]." [OBOL:automatic] synonym: "lymphoid tissue of thymus" EXACT [OBOL:automatic] synonym: "lymphoid tissue of thymus gland" EXACT [OBOL:automatic] synonym: "thymus gland lymphoid tissue" EXACT [OBOL:automatic] xref: EMAPA:37766 {source="MA:th"} xref: http://linkedlifedata.com/resource/umls/id/C1515429 xref: MA:0002673 xref: MESH:A06.407.850 xref: NCIT:C38515 xref: UMLS:C1515429 {source="ncithesaurus:Thymic_Lymphoid_Tissue"} is_a: UBERON:0001744 ! lymphoid tissue relationship: part_of UBERON:0002370 ! thymus [Term] id: UBERON:0003529 name: respiratory system lymphatic vessel endothelium namespace: uberon def: "An lymphatic vessel endothelium that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] synonym: "apparatus respiratorius endothelium of lymph vessel" EXACT [OBOL:automatic] synonym: "apparatus respiratorius lymph vessel endothelium" EXACT [OBOL:automatic] synonym: "apparatus respiratorius lymphatic vessel endothelium" EXACT [OBOL:automatic] synonym: "endothelium of lymph vessel of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "endothelium of lymph vessel of respiratory system" EXACT [OBOL:automatic] synonym: "lymph vessel endothelium of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "lymph vessel endothelium of respiratory system" EXACT [OBOL:automatic] synonym: "lymphatic vessel endothelium of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "lymphatic vessel endothelium of respiratory system" EXACT [OBOL:automatic] synonym: "respiratory system endothelium of lymph vessel" EXACT [OBOL:automatic] synonym: "respiratory system lymph vessel endothelium" EXACT [OBOL:automatic] synonym: "respiratory system lymphatic vessel endothelium" EXACT [OBOL:automatic] xref: EMAPA:37581 {source="MA:th"} xref: MA:0001825 is_a: UBERON:0002042 ! lymphatic vessel endothelium relationship: part_of UBERON:0003456 ! respiratory system lymphatic vessel [Term] id: UBERON:0003846 name: thymus epithelium namespace: uberon def: "An epithelium that is part of a thymus, forming a supporting framework[MP,modified]." [MP:0009544] subset: pheno_slim synonym: "epithelial tissue of thymus" EXACT [OBOL:automatic] synonym: "epithelial tissue of thymus gland" EXACT [OBOL:automatic] synonym: "epithelium of thymus" EXACT [OBOL:automatic] synonym: "epithelium of thymus gland" EXACT [OBOL:automatic] synonym: "thymic epithelial tissue" EXACT [] synonym: "thymic epithelium" EXACT [BTO:0001836] synonym: "thymus epithelial tissue" EXACT [OBOL:automatic] synonym: "thymus gland epithelial tissue" EXACT [OBOL:automatic] synonym: "thymus gland epithelium" EXACT [OBOL:automatic] xref: BTO:0001836 xref: CALOHA:TS-1040 xref: EHDAA2:0002019 xref: EMAPA:35864 xref: http://linkedlifedata.com/resource/umls/id/C1711423 xref: MA:0000768 xref: NCIT:C45713 xref: UMLS:C1711423 {source="ncithesaurus:Thymic_Epithelial_Tissue"} xref: VHOG:0001426 xref: ZFA:0005779 relationship: part_of UBERON:0002370 ! thymus [Term] id: UBERON:0003910 name: splenic sinusoid namespace: uberon def: "wide vessels in the spleen that drain into trabecular veins[WP]." [http://en.wikipedia.org/wiki/Red_pulp#Sinusoids] synonym: "sinusoid of red pulp of spleen" RELATED [FMA:63199] synonym: "sinusoidal blood vessel of spleen" EXACT [OBOL:automatic] xref: FMA:63199 xref: http://www.snomedbrowser.com/Codes/Details/9081000 xref: Sinusoids relationship: part_of UBERON:0001250 ! red pulp of spleen property_value: RO:0002175 NCBITaxon:10114 {source="http://www.informatics.jax.org/greenbook/chapters/chapter13.shtml"} property_value: UBPROP:0000008 "Whereas man and the rat are in the 'sinusal' group, the mouse belongs in the 'nonsinusal' group. The red pulp of spleens of rat, dog, man, and many other mammals contains an elaborate plexus of sinuses; that of mouse, cat, pig and others has no true sinuses and relatively few veins leading from the meshes into collecting veins - http://www.informatics.jax.org/greenbook/chapters/chapter13.shtml" xsd:string [Term] id: UBERON:0003949 name: tubal tonsil namespace: uberon def: "The lymph tissue associated with the pharyngeal opening of the auditory tube" [MP:0002386] subset: pheno_slim synonym: "auditory tube lymph gland" EXACT [FMA:54975] synonym: "eustachian amygdala" EXACT [FMA:54975] synonym: "Gerlach's tonsil" EXACT [FMA:54975] synonym: "Gerlach's tubal tonsil" EXACT [FMA:54975] xref: FMA:54975 xref: http://www.snomedbrowser.com/Codes/Details/143319002 xref: Tubal:tonsil is_a: UBERON:0002372 ! tonsil [Term] id: UBERON:0003968 name: peripheral lymph node namespace: uberon def: "The lymph nodes located outside the thoracic and abdominal cavities, such as the submandibular, prescapular, axillary, inguinal and popliteal lymph nodes" [https://github.com/obophenotype/uberon/issues/4, MP:0008463] subset: pheno_slim xref: EMAPA:37938 {source="MA:th"} is_a: UBERON:0000029 ! lymph node property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/cmungall property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/tmeehan [Term] id: UBERON:0003987 name: Hassall's corpuscle namespace: uberon def: "The small spherical bodies of epithelial cells found in the medulla of the thymus, that are arranged in a concentric pattern around clusters of degenerating lymphocytes, eosinophils and macrophages" [MP:0009539] subset: pheno_slim synonym: "capsule of Hassal's corpuscle" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "thymic corpuscle" EXACT [] xref: EMAPA:35395 xref: Hassall's:corpuscles xref: http://linkedlifedata.com/resource/umls/id/C0229950 xref: http://www.snomedbrowser.com/Codes/Details/34223001 xref: MA:0000772 xref: NCIT:C13170 xref: UMLS:C0229950 {source="ncithesaurus:Hassall_s_Corpuscle"} relationship: part_of UBERON:0002124 ! medulla of thymus relationship: part_of UBERON:0003846 ! thymus epithelium [Term] id: UBERON:0003988 name: thymus corticomedullary boundary namespace: uberon def: "The dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells" [MP:0009543] subset: pheno_slim synonym: "thymic cortico-medullary boundary" EXACT [MP:0009543] synonym: "thymic corticomedullary boundary" EXACT [MP:0009543] synonym: "thymic corticomedullary junction" EXACT [MP:0009543] synonym: "thymic corticomedullary zone" EXACT [MP:0009543] synonym: "thymus CMZ" EXACT [MP:0009543] synonym: "thymus cortico-medullary boundary" EXACT [MP:0009543] synonym: "thymus corticomedullary junction" EXACT [MP:0009543] synonym: "thymus corticomedullary zone" EXACT [MP:0009543] xref: EMAPA:37974 {source="MA:th"} relationship: part_of UBERON:0002125 ! thymus lobule [Term] id: UBERON:0004041 name: spleen primary B follicle namespace: uberon def: "The nodules of small undifferentiated B lymphocytes and follicular dendritic cells located in the spleen white pulp" [MP:0008471] subset: pheno_slim synonym: "primary spleen B cell follicle" EXACT [CL:tm] xref: EMAPA:37960 {source="MA:th"} xref: FMA:15843 is_a: UBERON:0001249 ! spleen lymphoid follicle is_a: UBERON:0010422 ! primary nodular lymphoid tissue property_value: UBPROP:0000012 "FMA:15843 is classified as primary follicle so it belongs here" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0004042 name: spleen secondary B follicle namespace: uberon def: "The nodules of antigen-activated, differentiating B cells, follicular dendritic cells, antigen-presenting T cells and macrophages in the spleen white pulp" [MP:0008472] subset: pheno_slim synonym: "secondary spleen B cell follicle" EXACT [CL:tm] synonym: "splenic secondary B cell follicle" EXACT [MP:0008472] xref: EMAPA:37961 {source="MA:th"} is_a: UBERON:0001249 ! spleen lymphoid follicle is_a: UBERON:0001745 ! secondary nodular lymphoid tissue [Term] id: UBERON:0004232 name: lymphatic vessel smooth muscle namespace: uberon def: "A portion of smooth muscle tissue that is part of a lymphatic vessel [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "involuntary muscle of lymph vessel" EXACT [OBOL:automatic] synonym: "involuntary muscle of lymphatic vessel" EXACT [OBOL:automatic] synonym: "lymph vessel involuntary muscle" EXACT [OBOL:automatic] synonym: "lymph vessel non-striated muscle" EXACT [OBOL:automatic] synonym: "lymph vessel smooth muscle" EXACT [OBOL:automatic] synonym: "lymph vessel smooth muscle tissue" EXACT [OBOL:automatic] synonym: "lymphatic vessel involuntary muscle" EXACT [OBOL:automatic] synonym: "lymphatic vessel non-striated muscle" EXACT [OBOL:automatic] synonym: "lymphatic vessel smooth muscle tissue" EXACT [OBOL:automatic] synonym: "non-striated muscle of lymph vessel" EXACT [OBOL:automatic] synonym: "non-striated muscle of lymphatic vessel" EXACT [OBOL:automatic] synonym: "smooth muscle of lymph vessel" EXACT [OBOL:automatic] synonym: "smooth muscle of lymphatic vessel" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of lymph vessel" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of lymphatic vessel" EXACT [OBOL:automatic] xref: EMAPA:36313 xref: FMA:262026 xref: http://linkedlifedata.com/resource/umls/id/C1708791 xref: MA:0000751 xref: NCIT:C49260 xref: UMLS:C1708791 {source="ncithesaurus:Lymphatic_Vessel_Smooth_Muscle_Tissue"} relationship: part_of UBERON:0001473 ! lymphatic vessel [Term] id: UBERON:0004238 name: spleen smooth muscle namespace: uberon def: "A portion of smooth muscle tissue that is part of a spleen [Automatically generated definition]." [OBOL:automatic] synonym: "involuntary muscle of spleen" EXACT [OBOL:automatic] synonym: "non-striated muscle of spleen" EXACT [OBOL:automatic] synonym: "smooth muscle of spleen" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of spleen" EXACT [OBOL:automatic] synonym: "spleen involuntary muscle" EXACT [OBOL:automatic] synonym: "spleen non-striated muscle" EXACT [OBOL:automatic] synonym: "spleen smooth muscle tissue" EXACT [OBOL:automatic] xref: EMAPA:35807 xref: MA:0000757 relationship: part_of UBERON:0002106 ! spleen [Term] id: UBERON:0004296 name: respiratory system lymphatic vessel smooth muscle namespace: uberon def: "A lymphatic vessel smooth muscle that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] synonym: "smooth muscle of lymph vessel of respiratory system" EXACT [OBOL:automatic] xref: EMAPA:37582 {source="MA:th"} xref: MA:0001826 is_a: UBERON:0004232 ! lymphatic vessel smooth muscle relationship: part_of UBERON:0003456 ! respiratory system lymphatic vessel [Term] id: UBERON:0004536 name: lymph vasculature namespace: uberon def: "A network of blunt ended vessels lacking direct connection to the blood vascular system. These vessels collect and drain fluids and macromolecules from interstitial spaces throughout the animal. They derive from a subpopulation of endothelial cells and have walls that are much thinner than the blood carrying vessels. Lymphatic vessels are usually classified as either superficial or deep." [ZFA:0005105] subset: vertebrate_core synonym: "lymph vessels" RELATED PLURAL [ZFA:0005105] synonym: "lymphatic trunks and ducts" EXACT [FMA:63815] synonym: "lymphatic vasculature" EXACT [] synonym: "lymphatic vessel network" EXACT [] synonym: "lymphatic vessels set" EXACT [FMA:63815] synonym: "set of lymphatic vessels" EXACT [] synonym: "trunci et ductus lymphatici" EXACT LATIN [FMA:63815, FMA:TA] xref: FMA:63815 xref: TAO:0005105 xref: ZFA:0005105 relationship: part_of UBERON:0006558 ! lymphatic part of lymphoid system property_value: IAO:0000116 "consider merging with parent" xsd:string property_value: UBPROP:0000001 "A network of blunt ended vessels lacking direct connection to the blood vascular system. These vessels collect and drain fluids and macromolecules from interstitial spaces throughout the animal. They derive from a subpopulation of endothelial cells and have walls that are much thinner than the blood carrying vessels. Lymphatic vessels are usually classified as either superficial or deep.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005105", ontology="TAO", source="ZFIN:curator"} [Term] id: UBERON:0004641 name: spleen capsule namespace: uberon def: "the connective tissue that surrounds the spleen" [MGI:cwg, MP:0002227] subset: pheno_slim synonym: "capsula splenica" EXACT LATIN [FMA:15849, FMA:TA] synonym: "capsule of spleen" EXACT [FMA:15849] synonym: "fibroelastic coat of spleen" EXACT [FMA:15849] synonym: "fibrous capsule of spleen" EXACT [FMA:15849] synonym: "Malpighian capsule" EXACT [FMA:15849] synonym: "splenic capsule" EXACT [FMA:15849] synonym: "tunica fibrosa (splen)(lien)" EXACT [FMA:15849] synonym: "tunica fibrosa splenica" EXACT LATIN [FMA:15849, FMA:TA] xref: EMAPA:35802 xref: FMA:15849 xref: http://linkedlifedata.com/resource/umls/id/C0229681 xref: http://www.snomedbrowser.com/Codes/Details/329635002 xref: MA:0000753 xref: NCIT:C33598 xref: UMLS:C0229681 {source="ncithesaurus:Splenic_Capsule"} relationship: part_of UBERON:0002106 ! spleen [Term] id: UBERON:0004693 name: Peyer's patch epithelium namespace: uberon def: "the specialized epithelium of the Peyer's patch" [ISBN:0-8153-1691-7, MGI:cwg, MP:0002388] subset: pheno_slim synonym: "peyer's patch epithelium" EXACT [MA:0000731] xref: EMAPA:36506 xref: MA:0000731 relationship: part_of UBERON:0001211 ! Peyer's patch [Term] id: UBERON:0004697 name: Peyer's patch germinal center namespace: uberon def: "Area of the Peyer's patch where B cells proliferate and differentiate into plasma cells" [MP:0002391] subset: pheno_slim xref: EMAPA:35684 xref: http://linkedlifedata.com/resource/umls/id/C1711398 xref: MA:0000734 xref: NCIT:C49600 xref: UMLS:C1711398 {source="ncithesaurus:Peyer_s_Patch_Germinal_Center"} is_a: UBERON:0010754 ! germinal center relationship: part_of UBERON:0001211 ! Peyer's patch [Term] id: UBERON:0004722 name: deep cervical lymph node namespace: uberon def: "The deep cervical lymph nodes are a group of cervical lymph nodes found near the internal jugular vein. They can be divided into upper and lower groups, or superior and inferior groups. Alternatively, they can be divided into deep anterior cervical lymph nodes and deep lateral cervical lymph nodes. They can also be divided into three groups: superior deep jugular, middle deep jugular, and 'inferior deep jugular'." [http://en.wikipedia.org/wiki/Deep_cervical_lymph_nodes] synonym: "lower jugular nodes" RELATED [http://en.wikipedia.org/wiki/Deep_cervical_lymph_nodes] synonym: "middle jugular nodes" RELATED [http://en.wikipedia.org/wiki/Deep_cervical_lymph_nodes] synonym: "upper jugular nodes" RELATED [http://en.wikipedia.org/wiki/Deep_cervical_lymph_nodes] xref: EMAPA:37510 {source="MA:th"} xref: http://en.wikipedia.org/wiki/Deep_cervical_lymph_nodes xref: http://linkedlifedata.com/resource/umls/id/C0458298 xref: http://www.snomedbrowser.com/Codes/Details/279145002 xref: MA:0002885 xref: NCIT:C32431 xref: UMLS:C0458298 {source="ncithesaurus:Deep_Cervical_Lymph_Node"} is_a: UBERON:0002429 ! cervical lymph node is_a: UBERON:0015918 ! deep lymph node property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b6/Illu_lymph_chain02.jpg xsd:anyURI [Term] id: UBERON:0004791 name: thymus trabecula namespace: uberon def: "the thymic connective tissue which extends into the parenchyma" [ISBN:0-397-51047-0, MGI:cwg, MP:0002370] subset: pheno_slim synonym: "thymic trabecula" EXACT [OBOL:automatic] synonym: "thymus gland trabecula" EXACT [OBOL:automatic] synonym: "trabecula of thymus" EXACT [OBOL:automatic] synonym: "trabecula of thymus gland" EXACT [OBOL:automatic] xref: http://linkedlifedata.com/resource/umls/id/C1515431 xref: MA:0002674 xref: NCIT:C33773 xref: UMLS:C1515431 {source="ncithesaurus:Thymic_Trabecula"} relationship: part_of UBERON:0002370 {source="MA"} ! thymus [Term] id: UBERON:0004850 name: lymph node endothelium namespace: uberon def: "An endothelium that is part of a lymph node [Automatically generated definition]." [OBOL:automatic] synonym: "endothelium of lymph node" EXACT [OBOL:automatic] xref: EMAPA:35526 xref: MA:0000741 relationship: part_of UBERON:0000029 ! lymph node [Term] id: UBERON:0004870 name: superficial cervical lymph node namespace: uberon def: "A group of nodes lying along the external jugular vein; they drain the skin and superficial structures over the region of the sternocleidomastoid muscle and anterior cervical regions. Efferent vessels drain to the deep cervical lymph nodes. Lymph nodes can be further subdivided into anterior and lateral groupings." [CL:tm, http://en.wikipedia.org/wiki/Superficial_cervical_lymph_nodes, https://github.com/obophenotype/uberon/issues/5, ref:Stedmans] synonym: "nodi lymphoidei cervicales" RELATED LATIN [http://en.wikipedia.org/wiki/Superficial_cervical_lymph_nodes] synonym: "prescapular lymph node" RELATED [CL:tm] xref: EMAPA:37725 {source="MA:th"} xref: http://en.wikipedia.org/wiki/Superficial_cervical_lymph_nodes xref: http://linkedlifedata.com/resource/umls/id/C0458297 xref: http://www.snomedbrowser.com/Codes/Details/279144003 xref: MA:0002886 xref: NCIT:C33659 xref: UMLS:C0458297 {source="ncithesaurus:Superficial_Cervical_Lymph_Node"} is_a: UBERON:0002429 ! cervical lymph node is_a: UBERON:0003968 {source="CL:tm"} ! peripheral lymph node is_a: UBERON:0015917 ! superficial lymph node property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/4/4e/Illu_quiz_hn_03.jpg xsd:anyURI property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/cmungall property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/tmeehan property_value: RO:0002174 NCBITaxon:10090 {source="http://www.ncbi.nlm.nih.gov/pubmed/16624319"} [Term] id: UBERON:0005057 name: immune organ namespace: uberon def: "An organ that is part of a immune system [Automatically generated definition]." [OBOL:automatic] subset: organ_slim subset: pheno_slim synonym: "immune system organ" EXACT [] relationship: part_of UBERON:0002405 ! immune system [Term] id: UBERON:0005196 name: spleen germinal center namespace: uberon def: "A germinal center that is part of the spleen. The spleen germinal center is located in a secondary B follicle in the white pulp of the spleen." [CL:tm, https://github.com/obophenotype/uberon/issues/6] subset: pheno_slim synonym: "germinal center of spleen" EXACT [] synonym: "spleen follicle center" EXACT [MP:0008474] synonym: "spleen GC" EXACT [MP:0008474] synonym: "splenic germinal center" EXACT [MP:0008474] xref: EMAPA:35803 xref: http://linkedlifedata.com/resource/umls/id/C1710156 xref: MA:0000764 xref: NCIT:C49760 xref: UMLS:C1710156 {source="ncithesaurus:Spleen_Germinal_Center"} is_a: UBERON:0010754 ! germinal center relationship: part_of UBERON:0004042 {source="CL:tm"} ! spleen secondary B follicle property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/cmungall property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/tmeehan [Term] id: UBERON:0005207 name: tonsil capsule namespace: uberon def: "A capsule that is part of a tonsil [Automatically generated definition]." [OBOL:automatic] xref: FMA:294647 xref: MA:0000776 relationship: part_of UBERON:0002372 ! tonsil [Term] id: UBERON:0005353 name: spleen perifollicular zone namespace: uberon def: "The compartment located between the marginal zone and the red pulp harboring scattered B and T lymphocytes[MP]." [MP:0010245] subset: pheno_slim relationship: part_of UBERON:0002106 ! spleen property_value: IAO:0000116 "TODO - check spleen marginal sinus" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000008 "The perifollicular zone, which is present in human and not rodents, may be the functional equivalent of the marginal sinus in rodents." xsd:string {source="MP:0002363"} [Term] id: UBERON:0005435 name: upper part of cisterna chyli namespace: uberon def: "A dilated sac at the lower end of the thoracic duct into which lymph from the intestinal trunk and two lumbar lymphatic trunks flow." [http://en.wikipedia.org/wiki/Cisterna_chyli] synonym: "atypical confluence of lymph trunks" EXACT [FMA:5835] synonym: "chyle cistern" EXACT [FMA:5835] synonym: "chyle cistern" RELATED [http://en.wikipedia.org/wiki/Cisterna_chyli] synonym: "cistern of Pecquet" EXACT [FMA:5835] synonym: "cisterna chyli" EXACT [FMA:5835] synonym: "cysterna chyli" RELATED LATIN [http://en.wikipedia.org/wiki/Cisterna_chyli] synonym: "receptaculum chyli" RELATED LATIN [http://en.wikipedia.org/wiki/Cisterna_chyli] xref: Cisterna:chyli xref: EHDAA2:0000253 xref: EHDAA:8679 xref: FMA:5835 xref: http://linkedlifedata.com/resource/umls/id/C0008840 xref: http://www.snomedbrowser.com/Codes/Details/279088007 xref: NCIT:C34126 xref: UMLS:C0008840 {source="ncithesaurus:Chyle_Cistern"} relationship: part_of UBERON:0001631 ! thoracic duct property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/75/Gray599.png xsd:anyURI property_value: UBPROP:0000008 "In dogs, it is located to the left and often ventral to the aorta; in cats it is left and dorsal; in guinea pigs it runs to the left and drains into the left innominate vein" xsd:string [Term] id: UBERON:0005457 name: left thymus lobe namespace: uberon def: "A thymus lobe that is in the left side of a thymus." [OBOL:automatic] synonym: "left lobe of thymus" EXACT [FMA:71195] synonym: "left thymic lobe" EXACT [FMA:71195] xref: FMA:71195 xref: http://www.snomedbrowser.com/Codes/Details/188079002 xref: RETIRED_EHDAA2:0000964 is_a: UBERON:0005483 ! thymus lobe property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern xsd:anyURI [Term] id: UBERON:0005463 name: subcapsular sinus of lymph node namespace: uberon def: "A space between the capsule and the cortex which allows the free movement of lymphatic fluid and so contains a sparsity of lymphocytes. It is continuous with the similar lymph sinuses that flank the trabeculae." [http://en.wikipedia.org/wiki/Lymph_node#Subcapsular_sinus] synonym: "lymph node subcortical sinus" EXACT [MA:0003027] synonym: "lymph path" RELATED [http://en.wikipedia.org/wiki/Subcapsular_sinus] synonym: "lymph sinus" RELATED [http://en.wikipedia.org/wiki/Subcapsular_sinus] synonym: "marginal sinus" BROAD [http://en.wikipedia.org/wiki/Subcapsular_sinus] synonym: "marginal sinus of lymph node" RELATED [http://en.wikipedia.org/wiki/Subcapsular_sinus] synonym: "subcapsular sinus" RELATED [http://en.wikipedia.org/wiki/Subcapsular_sinus] xref: EMAPA:37662 {source="MA:th"} xref: FMA:312355 xref: http://linkedlifedata.com/resource/umls/id/C1518051 xref: http://linkedlifedata.com/resource/umls/id/C1518052 xref: MA:0003027 xref: NCIT:C33033 xref: NCIT:C33642 xref: Subcapsular:sinus xref: UMLS:C1518051 {source="ncithesaurus:Lymph_Node_Sinus"} xref: UMLS:C1518052 {source="ncithesaurus:Lymph_Node_Subcapsular_Sinus"} relationship: part_of UBERON:0000029 ! lymph node property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/68/Gray597.png xsd:anyURI [Term] id: UBERON:0005469 name: right thymus lobe namespace: uberon def: "A thymus lobe that is in the right side of a thymus." [OBOL:automatic] synonym: "right lobe of thymus" EXACT [FMA:71194] synonym: "right thymic lobe" EXACT [FMA:71194] xref: FMA:71194 xref: http://www.snomedbrowser.com/Codes/Details/187981000 xref: RETIRED_EHDAA2:0001758 is_a: UBERON:0005483 ! thymus lobe property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern xsd:anyURI [Term] id: UBERON:0005483 name: thymus lobe namespace: uberon def: "Either of the two lateral lobes that constitute the thymus." [http://orcid.org/0000-0002-6601-2165] synonym: "lateral lobe of thymus" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "lobe of thymus" EXACT [FMA:71193] xref: FMA:71193 xref: RETIRED_EHDAA2:0002021 relationship: part_of UBERON:0002370 ! thymus property_value: UBPROP:0000010 "each lobe of the thymus can be divided into a central medulla and a peripheral cortex which is surrounded by an outer capsule. Each lobe is composed of numerous lobules held together by delicate areolar tissue; the entire organ being enclosed in an investing capsule of a similar but denser structure. The primary lobules vary in size from that of a pin's head to that of a small pea, and are made up of a number of small nodules or follicles.[WP]" xsd:string [Term] id: UBERON:0005562 name: thymus primordium namespace: uberon def: "A small outgrowth of the pharyngeal epithelium that is the site of lymphocyte cell production[ZFA]. [PMID]." [ZFA:0001077] subset: efo_slim subset: vertebrate_core synonym: "thymic primordium" EXACT [OBOL:automatic] synonym: "thymic rudiment" EXACT [ZFA:0001077] xref: EFO:0003622 xref: EHDAA2:0002023 xref: EHDAA:2969 xref: EMAPA:17523 xref: TAO:0001077 xref: ZFA:0001077 relationship: part_of UBERON:0002405 {source="ZFA"} ! immune system property_value: IAO:0000116 "we follow Kardong table 13.1 in having some developmental contribution of pouch 4 in mammals, but this isn't reflected in EHDAA2. Consider adding distinct term for mesenchyme (see EHDAA2), to indicate NC constribution." xsd:string {source="ISBN:0781714125"} property_value: UBPROP:0000001 "A small outgrowth of the pharyngeal epithelium that is the site of lymphocyte cell production. Willett et al, 1999.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001077", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000008 "variability of developmental origin: In fish, thymic primordia are generated by all the pouches except the first. However, in avians the thymus arises from pouches 3 and 4, whereas in humans it is only generated by the third pouch[PMID:16313389] The thymus arises from the second pouch in frogs, 2-6 in cartilaginous fish, 2-3 in reptiles, 3 or 4 in bony fish, birds and mammals. The final number is variable - 5 paired organs in sharks, 4 in caecilians, 3 in urodeles, 1 in many teleost, anurans and many mammals" xsd:string {source="ISBN:0781714125"} [Term] id: UBERON:0006558 name: lymphatic part of lymphoid system namespace: uberon def: "An organ system subdivision that is a network of vessels capable of removing accumulating protein and fluid from the interstitial space and returning it to the vascular space. In some species, this network is connected to the immune system via lymph nodes and lymphocyte-producing organs, with the whole being the lymphoid system." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: pheno_slim synonym: "lymphatic system" EXACT [FMA:7162, MA:0002435] synonym: "lymphatic tree system" EXACT [FMA:7162] synonym: "lymporeticular system" RELATED [VHOG:0001761] xref: AAO:0010522 xref: CALOHA:TS-2024 xref: EFO:0000870 xref: EMAPA:18248 xref: FMA:7162 xref: http://www.snomedbrowser.com/Codes/Details/362597000 xref: Lymphatic:system xref: MA:0002961 xref: MESH:D008208 xref: VHOG:0001761 relationship: part_of UBERON:0002465 {source="FMA", source="MA"} ! lymphoid system property_value: IAO:0000116 "consider merging with lymph vasculature" xsd:string property_value: UBPROP:0000001 "Part of the circulatory system which consists of a series of vessels which collect blood (exclusive of erythrocytes) which seep through capillary walls and return it to the veins.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010522", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000007 "lymporeticular" xsd:string property_value: UBPROP:0000012 "in FMA this is part of the cardiovascular system, but here we treat the CV system as a separate component of the circulatory system from the lymphatic system" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0006561 name: non-lymphatic part of lymphoid system namespace: uberon def: "An organ system subdivision that is the part of the lymphoid system that excludes the lymphatic vessels.." [http://orcid.org/0000-0002-6601-2165] synonym: "non-lymphatic lymphoid system" EXACT [FMA:74623] xref: FMA:74623 relationship: part_of UBERON:0002465 ! lymphoid system [Term] id: UBERON:0006842 name: lymphatic capillary namespace: uberon def: "Microvessel of the lymphatic system lined with a single layer of overlapping endothelial cells. Joins to form the lymphatic vessels." [ZFA:0005252] subset: vertebrate_core synonym: "lymph capillary" EXACT [FMA:5028] xref: FMA:5028 xref: http://linkedlifedata.com/resource/umls/id/C0162405 xref: NCIT:C33037 xref: TAO:0005252 xref: UMLS:C0162405 {source="ncithesaurus:Lymphatic_Capillary"} xref: ZFA:0005252 is_a: UBERON:0001473 {source="FMA"} ! lymphatic vessel property_value: IAO:0000116 "TODO - check superclass" xsd:string property_value: UBPROP:0000001 "Microvessel of the lymphatic system lined with a single layer of overlapping endothelial cells.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005252", ontology="TAO", source="ZFIN:curator"} [Term] id: UBERON:0006936 name: thymus subcapsular epithelium namespace: uberon def: "the epithelial cells lining the capsule and trabeculae of the thymus" [ISBN:0-8153-1691-7, MGI:cwg, MP:0002369] subset: pheno_slim xref: MA:0000769 is_a: UBERON:0003846 ! thymus epithelium relationship: part_of UBERON:0002122 ! capsule of thymus property_value: IAO:0000116 "TODO - check whether this is part of the thymus or borders it" xsd:string [Term] id: UBERON:0007195 name: stroma of bone marrow namespace: uberon def: "The stroma of the bone marrow is all tissue not directly involved in the primary function of hematopoiesis. The yellow bone marrow belongs here, and makes the majority of the bone marrow stroma, in addition to stromal cells located in the red bone marrow. Yellow bone marrow is found in the Medullary cavity. Still, the stroma is indirectly involved in hematopoiesis, since it provides the hematopoietic microenvironment that facilitates hematopoiesis by the parenchymal cells. For instance, they generate colony stimulating factors, affecting hematopoiesis." [http://en.wikipedia.org/wiki/Bone_marrow#Stroma] synonym: "bone marrow stroma" EXACT [FMA:21426] xref: CALOHA:TS-0085 xref: FMA:21426 xref: Stroma relationship: part_of UBERON:0002371 ! bone marrow [Term] id: UBERON:0007250 name: lingual tonsil namespace: uberon def: "the lymph tissue on the floor of the oropharyngeal passage, near the root of the tongue" [MGI:cwg, MP:0002385] subset: pheno_slim synonym: "lingual tonsillar tissue" EXACT [MA:0000773] synonym: "tonsilla lingualis" RELATED LATIN [http://en.wikipedia.org/wiki/Lingual_tonsils] xref: FMA:54836 xref: http://linkedlifedata.com/resource/umls/id/C0229871 xref: http://www.snomedbrowser.com/Codes/Details/276957006 xref: Lingual:tonsils xref: MA:0000773 xref: NCIT:C32988 xref: UMLS:C0229871 {source="ncithesaurus:Lingual_Tonsil"} is_a: UBERON:0002372 ! tonsil property_value: depicted:by Illu04:tongue.jpg xsd:anyURI [Term] id: UBERON:0007384 name: appendage lymph vessel namespace: uberon def: "A lymphatic vessel that is part of a limb/fin." [OBOL:automatic] xref: TAO:0005300 xref: ZFA:0005300 is_a: UBERON:0001473 ! lymphatic vessel [Term] id: UBERON:0007385 name: pectoral appendage lymph vessel namespace: uberon def: "A lymphatic vessel that is part of a pectoral appendage." [OBOL:automatic] xref: TAO:0005302 xref: ZFA:0005302 is_a: UBERON:0007384 ! appendage lymph vessel [Term] id: UBERON:0007386 name: pelvic appendage lymph vessel namespace: uberon def: "A lymphatic vessel that is part of a pelvic appendage." [OBOL:automatic] is_a: UBERON:0007384 ! appendage lymph vessel [Term] id: UBERON:0007643 name: node of ligamentum arteriosum namespace: uberon def: "An inconstant lymph node of the anterior mediastinal group located adjacent to the ligamentum arteriosum." [http://www.mondofacto.com/facts/dictionary?node+of+ligamentum+arteriosum] synonym: "Botallo's node" EXACT [FMA:74033] synonym: "ligamentum arteriosum node" EXACT [FMA:74033] synonym: "lymph node of ligamentum arteriosum" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "nodus ligamenti arteriosi" EXACT [http://www.mondofacto.com/facts/dictionary?node+of+ligamentum+arteriosum] xref: FMA:74033 is_a: UBERON:0002524 {source="FMA"} ! mediastinal lymph node [Term] id: UBERON:0007644 name: thoracic lymph node namespace: uberon def: "A lymph node that is part of a thorax. Includes lymph nodes of the lungs and mediastinal lymph nodes" [http://en.wikipedia.org/wiki/Lymph_node#Lymph_nodes_of_the_thorax, OBOL:automatic] synonym: "deep thoracic lymph node" RELATED [FMA:12772] synonym: "lymph node of thorax" EXACT [FMA:12772] xref: FMA:12772 xref: http://linkedlifedata.com/resource/umls/id/C0229745 xref: http://www.snomedbrowser.com/Codes/Details/196374005 xref: Lymph_nodes_of_the_thorax xref: NCIT:C33769 xref: UMLS:C0229745 {source="ncithesaurus:Thoracic_Lymph_Node"} is_a: UBERON:0000029 ! lymph node [Term] id: UBERON:0008817 name: thymus primordium endoderm namespace: uberon def: "An endoderm that is part of a thymus primordium." [OBOL:automatic] relationship: part_of UBERON:0005562 ! thymus primordium [Term] id: UBERON:0009006 name: deep inguinal lymph node namespace: uberon def: "One of several small inconstant lymph nodes, proximal, intermediate and distal deep to the fascia lata and medial to the femoral vein; they receive lymph from the deep structures of the lower limb, from the glans penis and from superficial inguinal nodes; efferents pass to the external iliac nodes." [BTO:0004548] synonym: "deep inguinal node" EXACT [FMA:44225] synonym: "nodi lymphatici inguinales profundi" RELATED LATIN [BTO:0004548] synonym: "nodus lymphaticus inguinalis profundus" EXACT LATIN [FMA:44225] xref: BTO:0004548 xref: FMA:44225 xref: http://en.wikipedia.org/wiki/Deep_inguinal_lymph_nodes xref: http://www.snomedbrowser.com/Codes/Details/65266007 is_a: UBERON:0001542 {source="Wikipedia"} ! inguinal lymph node [Term] id: UBERON:0009007 name: superficial inguinal lymph node namespace: uberon def: "A group of 12-20 lymph nodes that lie in the subcutaneous tissue below the inguinal ligament and along the terminal part of the great saphenous vein; they drain the skin and subcutaneous tissue of the lower abdominal wall, perineum, buttocks, external genitalia, and lower limbs." [BTO:0004549] synonym: "lymph node of Cloquet" EXACT [FMA:5036] synonym: "lymph node of Rosenmuller" EXACT [FMA:5036] synonym: "nodi lymphatici inguinales superficiali" RELATED PLURAL [] synonym: "nodus lymphaticus inguinalis superficialis" EXACT LATIN [FMA:5036] synonym: "superficial inguinal node" EXACT [FMA:5036] xref: BTO:0004549 xref: FMA:5036 xref: http://en.wikipedia.org/wiki/Superficial_inguinal_lymph_nodes xref: http://www.snomedbrowser.com/Codes/Details/113340006 is_a: UBERON:0001542 {source="Wikipedia"} ! inguinal lymph node is_a: UBERON:0015917 ! superficial lymph node [Term] id: UBERON:0009039 name: lymph node germinal center namespace: uberon def: "A germinal center that is located in a lymph node" [CL:tm] subset: pheno_slim synonym: "germinal center" BROAD [BTO:0003671] synonym: "lymph node activated zone" RELATED [] synonym: "lymph node central zone" RELATED [] synonym: "lymph node light zone" RELATED [] synonym: "lymph node nodule" RELATED [] xref: BTO:0003671 xref: CALOHA:TS-1269 xref: EMAPA:35528 xref: http://www.snomedbrowser.com/Codes/Details/327147000 xref: MA:0002989 xref: NCIT:C49757 is_a: UBERON:0010754 ! germinal center relationship: part_of UBERON:0010753 {source="MA"} ! lymph node secondary follicle [Term] id: UBERON:0009102 name: supraneural body namespace: uberon def: "One of the primary immunological organs of the adult lamprey is the supraneural body. This structure lies dorsal to spinal column and becomes heavily populated with lymphocytes following after immune challenge." [https://doi.org/10.2307/1442643] subset: organ_slim synonym: "dorsal fat body" EXACT [PMCID:PMC2093943] synonym: "pro-vertebral arch" EXACT [PMCID:PMC2093943] is_a: UBERON:0005057 ! immune organ property_value: UBPROP:0000008 "The supraneural body from hematopoietically stimulated lampreys appears to be histologically-similar to 'bone marrow' in higher vertebrates and contains all blood cell lineages and their precursors, including lymphocytes at all stages of maturity" xsd:string [Term] id: UBERON:0009114 name: cervical thymus namespace: uberon def: "A mature thymus that is entirely part of the cervical region." [https://orcid.org/0000-0002-6601-2165] subset: organ_slim is_a: UBERON:0002370 ! thymus property_value: RO:0002175 NCBITaxon:39107 property_value: RO:0002175 NCBITaxon:9263 property_value: UBPROP:0000008 "A cervical thymus is a pathological structure in a human - it can form during the migration of the thymus to its location in the mediastinum. Some mice have a cervical thymus. There are examples of cervical thymi in marsupials and prosimians[ISBN:0781714125]" xsd:string [Term] id: UBERON:0009115 name: thoracic thymus namespace: uberon def: "A mature thymus that is entirely part of thoracic region." [https://orcid.org/0000-0002-6601-2165] subset: organ_slim is_a: UBERON:0002370 ! thymus [Term] id: UBERON:0009116 name: thymoid namespace: uberon def: "A thymus-like lympho-epithelial structures, in the tips of the gill filaments and the neighbouring secondary lamellae (both within the gill basket) of lamprey larvae." [http://www.ncbi.nlm.nih.gov/pubmed/21293377] comment: Genes: FOXN1 subset: organ_slim is_a: UBERON:0005057 ! immune organ [Term] id: UBERON:0009744 name: lymph node medullary sinus namespace: uberon def: "The channels in the lymph node medulla that separate the medullary cords and are crossed by a reticulum of cells and fibers and bounded by littoral cells; lymph flows through the medullary sinus from the cortical sinuses and into the efferent lymphatic vessels" [MP:0011222] comment: Lymph flows into the medullary sinuses from cortical sinuses, and into efferent lymphatic vessels. Medullary sinuses contain histiocytes (immobile macrophages) and reticular cells.[WP] subset: pheno_slim synonym: "lymph node medullary sinusoid" RELATED [] synonym: "medullary sinus" BROAD [] xref: EMAPA:37898 {source="MA:th"} xref: FMA:312359 relationship: part_of UBERON:0002007 ! medulla of lymph node [Term] id: UBERON:0009745 name: lymph node medullary cord namespace: uberon def: "The dense rope-like structures of lymphatic tissue located between the medullary sinuses in the medulla of a lymph node" [MP:0011224] subset: pheno_slim synonym: "medullary cord" BROAD [] xref: EMAPA:37897 {source="MA:th"} relationship: part_of UBERON:0002007 ! medulla of lymph node [Term] id: UBERON:0009967 name: spleen venous sinus namespace: uberon synonym: "sinus lienalis" EXACT LATIN [FMA:TA] synonym: "sinus splenicus" EXACT LATIN [FMA:TA] synonym: "splenic sinus" EXACT [FMA:62815] synonym: "venous sinus of red pulp of spleen" EXACT [FMA:62815] xref: EMAPA:37751 {source="MA:th"} xref: FMA:62815 xref: http://linkedlifedata.com/resource/umls/id/C1179415 xref: MA:0000761 xref: NCIT:C33605 xref: UMLS:C1179415 {source="ncithesaurus:Splenic_Sinus"} relationship: part_of UBERON:0001250 {source="MA"} ! red pulp of spleen property_value: seeAlso UBERON:0003910 [Term] id: UBERON:0010014 name: epigonal organ namespace: uberon def: "An elongate paired tissue ventral to the kidneys and partialy enveloping the anterior gonads in Elasmobranchii. Apparently important to the immune system" [http://www.fishbase.org/glossary/Glossary.php?q=epigonal+organ] synonym: "subgonal organ" EXACT [] is_a: UBERON:0005057 ! immune organ [Term] id: UBERON:0010015 name: ventral patch of Leydig's organ namespace: uberon def: "The ventralmost of the two bodies of the elasmopbranch hemopoietic organ betweean the esophageal mucosa and muscularis" [http://orcid.org/0000-0002-6601-2165] relationship: part_of UBERON:0000040 ! Leydig's organ property_value: UBPROP:0000008 "Gradation varies in species. In the stingray, two distinct lobes are seen, in the banded dogfish each lobe is divided into lobules [Homma et al 1984]" xsd:string [Term] id: UBERON:0010051 name: dorsal patch of Leydig's organ namespace: uberon def: "The dosralmost of the two bodies of the elasmopbranch hemopoietic organ betweean the esophageal mucosa and muscularis" [http://orcid.org/0000-0002-6601-2165] relationship: part_of UBERON:0000040 ! Leydig's organ property_value: UBPROP:0000008 "Gradation varies in species. In the stingray, two distinct lobes are seen, in the banded dogfish each lobe is divided into lobules [Homma et al 1984]" xsd:string [Term] id: UBERON:0010160 name: lumen of lymphatic vessel namespace: uberon def: "An anatomical cavity that surrounded_by a lymphatic vessel." [OBOL:automatic] synonym: "lumen of lymphatic duct" EXACT [FMA:59681] synonym: "lymphatic vessel lumen" EXACT [FMA:59681] xref: FMA:59681 relationship: part_of UBERON:0001473 ! lymphatic vessel [Term] id: UBERON:0010174 name: Schweigger-Seidel sheath namespace: uberon def: "A phagocytic sleeve that is part of a sheathed arteriole of the spleen, and is sometimes referred to as a splenic ellipsoid. It is a spindle-shaped thickening in the walls of the second part of the arterial branches forming the penicilli in the spleen" [http://en.wikipedia.org/wiki/Schweigger-Seidel_sheath, PMCID:PMC3204613] xref: Schweigger-Seidel:sheath relationship: part_of UBERON:0002106 ! spleen [Term] id: UBERON:0010266 name: arthropod hepatopancreas namespace: uberon def: "Digestive gland of crustaceans with functions approximately analogous to liver and pancreas of vertebrates - enzyme secretion, food absorption and storage." [BTO:0000597] synonym: "crustacean digestive gland" RELATED [] synonym: "midgut gland" RELATED [BTO:0000597] is_a: UBERON:0005057 ! immune organ property_value: IAO:0000116 "this term should be ceded to the arthropod anatomy ontology" xsd:string [Term] id: UBERON:0010386 name: Peyer's patch follicle namespace: uberon def: "A lymphoid follicle that is part of a Peyer's patch." [OBOL:automatic] subset: pheno_slim synonym: "peyer's patch follicle" EXACT [MA:0000732] xref: MA:0000732 is_a: UBERON:0000444 ! lymphoid follicle relationship: part_of UBERON:0001211 ! Peyer's patch [Term] id: UBERON:0010387 name: Peyer's patch T cell area namespace: uberon def: "The Peyer's patch area normally occupied by T lymphocytes" [MP:0002392] subset: pheno_slim xref: EMAPA:37939 {source="MA:th"} is_a: UBERON:0010393 ! T cell domain relationship: part_of UBERON:0001211 ! Peyer's patch [Term] id: UBERON:0010392 name: B cell domain namespace: uberon is_a: UBERON:0010394 ! lymphocyte domain property_value: IAO:0000116 "TODO - check" xsd:string [Term] id: UBERON:0010393 name: T cell domain namespace: uberon is_a: UBERON:0010394 ! lymphocyte domain property_value: IAO:0000116 "TODO - check" xsd:string [Term] id: UBERON:0010394 name: lymphocyte domain namespace: uberon is_a: UBERON:0005057 ! immune organ relationship: part_of UBERON:0002465 ! lymphoid system property_value: IAO:0000116 "TODO - check" xsd:string property_value: seeAlso https://github.com/obophenotype/uberon/issues/513 xsd:anyURI [Term] id: UBERON:0010395 name: lymph node primary follicle namespace: uberon def: "An unstimulated network of follicular dendritic cells and small resting B cells in the lymph node cortex." [https://github.com/obophenotype/uberon/issues/6, MP:0002345] subset: pheno_slim synonym: "primary follicle of lymph node" EXACT [] xref: EMAPA:35530 xref: FMA:312350 xref: MA:0000743 is_a: UBERON:0010422 ! primary nodular lymphoid tissue is_a: UBERON:0010748 ! lymph node follicle property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/cmungall property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/tmeehan [Term] id: UBERON:0010396 name: afferent lymphatic vessel namespace: uberon def: "Lymphatic vessel that enters the lymph node. The afferent lymph vessels enter at all parts of the periphery of the lymph node, and after branching and forming a dense plexus in the substance of the capsule, open into the lymph sinuses of the cortical part. In doing this they lose all their coats except their endothelial lining, which is continuous with a layer of similar cells lining the lymph paths" [MP:MP] subset: pheno_slim synonym: "vasa afferentia lymphoglandula" EXACT [http://en.wikipedia.org/wiki/Afferent_lymphatic_vessels] synonym: "vasa afferentia lymphoglandulae" EXACT [http://en.wikipedia.org/wiki/Afferent_lymphatic_vessels] xref: http://en.wikipedia.org/wiki/File\:Illu_lymph_node_structure.png xref: MA:0000748 is_a: UBERON:0001473 ! lymphatic vessel relationship: part_of UBERON:0000029 ! lymph node [Term] id: UBERON:0010397 name: efferent lymphatic vessel namespace: uberon def: "Lymphatic vessel that exits the lymph node. The efferent lymphatic vessel commences from the lymph sinuses of the medullary portion of the lymph nodes and leave the lymph nodes either to veins or greater nodes. Efferent lymphatic vessels are also found in the thymus and spleen. This is in contrast to afferent lymphatic vessels, which are found only in lymph nodes." [MP:MP] subset: pheno_slim synonym: "efferent lymphatic vessel" RELATED [http://en.wikipedia.org/wiki/Efferent_lymph_vessel] synonym: "efferent lymphatic vessels" RELATED [http://en.wikipedia.org/wiki/Efferent_lymph_vessel] xref: http://en.wikipedia.org/wiki/Efferent_lymph_vessel xref: MA:0000749 is_a: UBERON:0001473 ! lymphatic vessel [Term] id: UBERON:0010398 name: spleen marginal sinus namespace: uberon def: "The border region surrounding the spleen B cell follicles and the periarteriolar lymphoid sheath that separates it from the marginal zone that mediates lymphocyte entry into the white pulp from the blood" [MP:MP] subset: pheno_slim synonym: "splenic marginal sinus" EXACT [MP:0002363] xref: EMAPA:37964 {source="MA:th", seeAlso="https://github.com/obophenotype/mouse-anatomy-ontology/issues/117"} xref: http://linkedlifedata.com/resource/umls/id/C1710157 xref: MA:0000754 xref: NCIT:C49776 xref: UMLS:C1710157 {source="ncithesaurus:Splenic_Marginal_Sinus"} is_a: UBERON:0001959 ! white pulp of spleen property_value: IAO:0000116 "Note that there is no consensus in the literature about which compartments constitute the white pulp or the ramifications of the microvasculature. In addition, notable differences exist between humans and rodents. In this ontology, the marginal sinus (which may not exist in human) has been included as part of the white pulp. The perifollicular zone, which is present in human and not rodents, may be the functional equivalent of the marginal sinus in rodents." xsd:string {source="MP:0002363"} [Term] id: UBERON:0010399 name: spleen trabecular artery namespace: uberon def: "one of the branches of the splenic artery[MP]" [http://en.wikipedia.org/wiki/Trabecular_arteries, MP:0002354] subset: pheno_slim synonym: "trabecular artery" RELATED [] xref: http://linkedlifedata.com/resource/umls/id/C1710159 xref: MA:0000759 xref: NCIT:C49775 xref: Trabecular:arteries xref: UMLS:C1710159 {source="ncithesaurus:Splenic_Trabecular_Artery"} relationship: part_of UBERON:0001265 ! trabecula of spleen property_value: UBPROP:0000001 "When the splenic artery passes into the trabecula of the spleen and branches, they become known as the trabecular arteries. When these arteries then reach the white pulp, and become covered with Periarteriolar lymphoid sheaths, the name changes again to central arteries (or central arterioles). Branches of the central arteries are given to the red pulp, and these are called penicillar arteries).[Wikipedia]" xsd:string {ontology="Wikipedia", source="Trabecular:arteries"} [Term] id: UBERON:0010400 name: spleen trabecular vein namespace: uberon def: "one of the veins that feed the splenic vein" [http://en.wikipedia.org/wiki/Trabecular_veins, MP:0002228] subset: pheno_slim synonym: "trabecular vein" RELATED [http://en.wikipedia.org/wiki/Trabecular_veins] xref: http://linkedlifedata.com/resource/umls/id/C1710160 xref: MA:0000760 xref: NCIT:C49779 xref: Trabecular:veins xref: UMLS:C1710160 {source="ncithesaurus:Splenic_Trabecular_Vein"} relationship: part_of UBERON:0001265 ! trabecula of spleen property_value: UBPROP:0000001 "The trabecular veins are the largest veins inside the spleen. It drains the blood collected in the sinuses of the pulp.[Wikipedia]" xsd:string {ontology="Wikipedia", source="Trabecular:veins"} [Term] id: UBERON:0010401 name: spleen central arteriole namespace: uberon def: "A blood vessel surrounded by the periarteriolar lymphoid sheath that connects the trabecular artery to the trabecular vein" [MP:MP] subset: pheno_slim synonym: "central arteriole" BROAD [] synonym: "follicular arteriole" EXACT [MP:0002361] synonym: "splenic arteriole" BROAD [] synonym: "splenic central arteriole" EXACT [MP:0002361] xref: MA:0000763 is_a: UBERON:0022292 ! splenic arteriole relationship: part_of UBERON:0001959 ! white pulp of spleen relationship: part_of UBERON:0010399 ! spleen trabecular artery [Term] id: UBERON:0010416 name: lymph node B cell domain namespace: uberon def: "A part of the lymph node cortex in which B lymphocytes home to primary follicles to survey follicular dendritic cells (FDCs); antigen stimulated B cells proliferate and differentiate within the follicles forming distinctive germinal centers" [MP:MP] subset: pheno_slim synonym: "lymph node B cell dependent cortex" EXACT [MP:0002344] synonym: "lymph node B-cell domain" EXACT [MP:0002344] synonym: "nodular lymph node cortex" EXACT [MP:0002344] xref: MA:0002851 is_a: UBERON:0010392 ! B cell domain relationship: part_of UBERON:0002006 {source="MP"} ! cortex of lymph node [Term] id: UBERON:0010417 name: lymph node T cell domain namespace: uberon def: "The paracortex and interfollicular cortex of the lymph node in which T lymphocytes home to survey dendritic cells" [MP:0002347] subset: pheno_slim synonym: "lymph node deep cortex" EXACT [MP:0002347] synonym: "lymph node T cell dependent paracortex" EXACT [MP:0002347] synonym: "lymph node T zone" EXACT [] synonym: "lymph node T-cell domain" EXACT [MP:0002347] synonym: "T cell zone of lymph node" EXACT [] synonym: "T zone of lymph node" EXACT [] xref: EMAPA:37663 {source="MA:th"} xref: http://www.snomedbrowser.com/Codes/Details/326870003 xref: MA:0002852 is_a: UBERON:0010393 ! T cell domain relationship: part_of UBERON:0002006 {source="MP"} ! cortex of lymph node [Term] id: UBERON:0010420 name: lymph node follicular corona namespace: uberon def: "A part of the secondary follicle in which naive B cells reside along with some helper T cells, macrophages and follicular dendritic cells; these are displaced by the expanding germinal centre and form a 'mantle' around it" [https://github.com/obophenotype/uberon/issues/7, MP:MP] subset: pheno_slim synonym: "lymph node B cell corona" EXACT [CL:tm] synonym: "lymph node dark zone" EXACT [CL:tm] synonym: "lymph node follicular mantle" EXACT [MA:0002990] synonym: "lymph node inactive zone" EXACT [CL:tm] synonym: "lymph node peripheral zone" EXACT [CL:tm] xref: EMAPA:37661 {source="MA:th"} xref: MA:0002990 is_a: UBERON:0010755 ! secondary follicle corona relationship: part_of UBERON:0010753 {source="MA"} ! lymph node secondary follicle property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/cmungall property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/tmeehan [Term] id: UBERON:0010421 name: spleen B cell corona namespace: uberon def: "The area of the (spleen) secondary B follicle that surrounds the germinal center and harbors the small recirculating B lymphocytes" [CL:tm, http://www.ncbi.nlm.nih.gov/pubmed/17495967, https://github.com/obophenotype/uberon/issues/6] subset: pheno_slim synonym: "B cell domain of the spleen" BROAD [MP:0002360] synonym: "B lymphocyte domain of the spleen" BROAD [] synonym: "follicle mantle" EXACT [MP:0002360] synonym: "lymphocytic corona" BROAD [CL:tm, MP:0002360] synonym: "spleen B cell corona" EXACT [MP:0002360] synonym: "spleen B-cell corona" EXACT [MP:0002360] synonym: "spleen lymphocytic corona" EXACT [CL:tm, MP:0002360] synonym: "spleen mantle zone" RELATED [CL:tm, MP:0002360] synonym: "splenic B cell corona" EXACT [MP:0002360] synonym: "splenic corona" BROAD [CL:tm] xref: EMAPA:37962 {source="MA:th"} is_a: UBERON:0010755 ! secondary follicle corona relationship: part_of UBERON:0004042 {source="CL:tm"} ! spleen secondary B follicle property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/cmungall property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/tmeehan [Term] id: UBERON:0010422 name: primary nodular lymphoid tissue namespace: uberon def: "A lymphoid follicle containing naive B cells" [CL:tm] synonym: "primary follicle" RELATED [] synonym: "primary lymphoid follicle" EXACT [] synonym: "primary lymphoid nodule" EXACT [FMA:55223] xref: FMA:55223 is_a: UBERON:0000444 {source="FMA"} ! lymphoid follicle property_value: UBPROP:0000015 "The cortex of lymph nodes, the white pulp of spleen, and mucosa associated lymphoid tissue all have these primary follicles" xsd:string [Term] id: UBERON:0010423 name: primary lymphoid nodule of tonsil namespace: uberon def: "A primary nodular lymphoid tissue that is part of a tonsil." [OBOL:automatic] synonym: "lymphoid nodule of tonsil" RELATED [FMA:86018] xref: FMA:86018 is_a: UBERON:0010422 {source="FMA"} ! primary nodular lymphoid tissue relationship: part_of UBERON:0002372 ! tonsil [Term] id: UBERON:0010748 name: lymph node follicle namespace: uberon def: "A lymphoid follicle that is part of a lymph node." [OBOL:automatic] synonym: "follicle of lymph node" EXACT [] xref: EMAPA:35527 xref: MA:0000742 is_a: UBERON:0000444 ! lymphoid follicle relationship: part_of UBERON:0002006 {notes="issues/7", source="MP-def"} ! cortex of lymph node [Term] id: UBERON:0010753 name: lymph node secondary follicle namespace: uberon def: "A secondary follicle that is located in a lymph node" [CL:tm] subset: pheno_slim xref: EMAPA:35531 xref: FMA:312352 xref: MA:0000744 is_a: UBERON:0001745 ! secondary nodular lymphoid tissue is_a: UBERON:0010748 {source="MA"} ! lymph node follicle [Term] id: UBERON:0010754 name: germinal center namespace: uberon def: "A collection of activated B cells at the center of a secondary follicle, formed after B cells become activated and migrate to the center." [CL:tm, http://en.wikipedia.org/wiki/Germinal_center, https://orcid.org/0000-0002-6601-2165] comment: A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation.[GO] synonym: "central zone of follice" EXACT [CL:tm] synonym: "light zone of follicle" EXACT [CL:tm] synonym: "lymhpoid nodule" RELATED [CL:tm] synonym: "nodule" RELATED [CL:tm] synonym: "reaction center of follicle" EXACT [CL:tm] xref: BTO:0003671 xref: EV:0100051 xref: Germinal:center xref: http://linkedlifedata.com/resource/umls/id/C0282491 xref: http://www.snomedbrowser.com/Codes/Details/64626006 xref: MESH:D018858 xref: NCIT:C13337 xref: UMLS:C0282491 {source="ncithesaurus:Germinal_Center"} is_a: UBERON:0001744 ! lymphoid tissue relationship: part_of UBERON:0001745 ! secondary nodular lymphoid tissue property_value: depicted:by Germinal:center.svg xsd:anyURI [Term] id: UBERON:0010755 name: secondary follicle corona namespace: uberon def: "The part of the secondary follicle that surrounds the germinal center." [CL:tm, https://orcid.org/0000-0002-6601-2165] synonym: "B cell corona" RELATED [] synonym: "dark zone of follicle" EXACT [CL:tm] synonym: "inactive zone of follicle" EXACT [CL:tm] synonym: "mantle zone" RELATED [] synonym: "peripheral zone of follicle" EXACT [CL:tm] xref: http://linkedlifedata.com/resource/umls/id/C1512987 xref: Mantle:zone xref: NCIT:C33053 xref: UMLS:C1512987 {source="ncithesaurus:Mantle_Zone"} is_a: UBERON:0001744 ! lymphoid tissue relationship: part_of UBERON:0001745 ! secondary nodular lymphoid tissue property_value: IAO:0000116 "consider making terminology consistent amongst subclasses - see https://github.com/obophenotype/uberon/issues/7" xsd:string [Term] id: UBERON:0010756 name: spleen follicular dendritic cell network namespace: uberon def: "The enmeshed group of antigen presenting cells with extensive dendritic processes in the spleen B cell follicle that present antigen to B cells during an immune response" [MP:0008473] comment: The follicular dendritic cell network is often visualized by using the monoclonal antibody FDC-M2. subset: pheno_slim synonym: "FDC network" BROAD [MP:0008473] synonym: "FDCN" BROAD [MP:0008473] synonym: "spleen FDC network" EXACT [MP:0008473] synonym: "splenic follicular dendritic cell network" EXACT [MP:0008473] xref: EMAPA:37963 {source="MA:th"} is_a: UBERON:0001744 ! lymphoid tissue relationship: part_of UBERON:0004042 ! spleen secondary B follicle [Term] id: UBERON:0011363 name: cranial lymph vasculature namespace: uberon def: "A lymph vasculature that is part of a head." [OBOL:automatic] synonym: "cranial lymph vessel" EXACT [ZFA:0005298] synonym: "cranial lymph vessels" RELATED PLURAL [TAO:0005298] synonym: "cranial lymphatics" EXACT [UBERON:cjm] synonym: "set of cranial lymphatic vessels" RELATED [FMA:224562] synonym: "set of lymphatic vessels of head" EXACT [FMA:224562] xref: FMA:224562 xref: TAO:0005298 xref: ZFA:0005298 is_a: UBERON:0004536 ! lymph vasculature [Term] id: UBERON:0011765 name: jugular lymph sac namespace: uberon def: "An embryonic lymph sac that forms at the junction of the future internal jugular/anterior cardinals and subclavian veins." [https://discovery.lifemapsc.com/library/review-of-medical-embryology/chapter-128-development-of-the-lymphatic-system, https://github.com/obophenotype/uberon/issues/1383, VHOG:0001000] xref: EMAPA:18249 xref: NCIT:C34196 xref: VHOG:0001000 is_a: UBERON:0034953 ! embryonic lymph sac property_value: UBPROP:0000001 "Lymphatic vessels develop from lymph sacs that arise from developing veins, which are derived from mesoderm. The first lymph sacs to appear are the paired jugular lymph sacs at the junction of the internal jugular and subclavian veins. [Wikipedia:Lymphatic_system][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001000", ontology="VHOG", source="http://bgee.unil.ch/"} [Term] id: UBERON:0012069 name: epithelium-associated lymphoid tissue namespace: uberon xref: FMA:62811 is_a: UBERON:0001744 {source="FMA"} ! lymphoid tissue [Term] id: UBERON:0012181 name: tonsil crypt namespace: uberon def: "Tonsils consist of an extensive system of crypts, which result in a large internal surface. The tonsils contain four lymphoid compartments that influence immune functions, namely the reticular crypt epithelium, the extrafollicular area, the mantle zones of lymphoid follicles, and the follicular germinal centers. In human palatine tonsils, the very first part exposed to the outside environment is tonsillar epithelium." [http://en.wikipedia.org/wiki/Tonsillar_crypts] synonym: "cryptae tonsillares" EXACT LATIN [http://en.wikipedia.org/wiki/Tonsillar_crypts] synonym: "tonsillar crypt" EXACT [FMA:55044] xref: FMA:55044 xref: http://linkedlifedata.com/resource/umls/id/C0229876 xref: http://www.snomedbrowser.com/Codes/Details/143723007 xref: MA:0000777 xref: NCIT:C33791 xref: Tonsillar:crypts xref: UMLS:C0229876 {source="ncithesaurus:Tonsillar_Crypt"} is_a: UBERON:0013696 ! tonsil epithelium [Term] id: UBERON:0012236 name: intercostal lymph node namespace: uberon def: "The intercostal lymph nodes (intercostal glands ) occupy the posterior parts of the intercostal spaces, in relation to the intercostal vessels. They receive the deep lymphatics from the postero-lateral aspect of the chest; some of these vessels are interrupted by small lateral intercostal glands." [http://en.wikipedia.org/wiki/Intercostal_lymph_nodes] synonym: "intercostal node" EXACT [FMA:5932] synonym: "nodi lymphoidei intercostales" EXACT [http://en.wikipedia.org/wiki/Intercostal_lymph_nodes] synonym: "nodus intercostale" EXACT [FMA:5932] xref: FMA:5932 xref: http://en.wikipedia.org/wiki/Intercostal_lymph_nodes xref: http://linkedlifedata.com/resource/umls/id/C0229761 xref: http://www.snomedbrowser.com/Codes/Details/204088001 xref: NCIT:C77652 xref: UMLS:C0229761 {source="ncithesaurus:Intercostal_Lymph_Node"} is_a: UBERON:0007644 {source="FMA"} ! thoracic lymph node [Term] id: UBERON:0012306 name: lateral cervical lymph node namespace: uberon def: "A cervical lymph nodes are found in proximity to an internal or external jugular vein." [http://en.wikipedia.org/wiki/Superficial_lateral_cervical_lymph_nodes, https://github.com/obophenotype/uberon/issues/5] synonym: "lateral cervical node" EXACT [FMA:61232] xref: FMA:61232 xref: http://www.snomedbrowser.com/Codes/Details/167763000 is_a: UBERON:0002429 {source="FMA"} ! cervical lymph node property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/cmungall property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/tmeehan [Term] id: UBERON:0012307 name: anterior cervical lymph node namespace: uberon def: "The anterior cervical lymph nodes are a group of nodes found on the anterior part of the neck." [http://en.wikipedia.org/wiki/Anterior_cervical_lymph_nodes, https://github.com/obophenotype/uberon/issues/5] synonym: "anterior cervical node" EXACT [] xref: FMA:61230 xref: http://en.wikipedia.org/wiki/Anterior_cervical_lymph_nodes xref: http://www.snomedbrowser.com/Codes/Details/168259009 is_a: UBERON:0002429 {source="FMA"} ! cervical lymph node property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/cmungall property_value: http://purl.org/dc/elements/1.1/contributor https://github.com/tmeehan [Term] id: UBERON:0012308 name: superficial lateral cervical lymph node namespace: uberon def: "The superficial lateral cervical lymph nodes are found in proximity to the external jugular vein." [http://en.wikipedia.org/wiki/Superficial_lateral_cervical_lymph_nodes] synonym: "superficial lateral cervical node" EXACT [FMA:12769] xref: FMA:12769 xref: http://en.wikipedia.org/wiki/Superficial_lateral_cervical_lymph_nodes xref: http://www.snomedbrowser.com/Codes/Details/50679006 is_a: UBERON:0004870 ! superficial cervical lymph node is_a: UBERON:0012306 {source="FMA"} ! lateral cervical lymph node [Term] id: UBERON:0012309 name: superficial anterior cervical lymph node namespace: uberon def: "The superficial anterior cervical lymph nodes are found in proximity to the anterior jugular vein." [http://en.wikipedia.org/wiki/Superficial_anterior_cervical_lymph_nodes] synonym: "anterior jugular lymph node" EXACT [FMA:12776] xref: FMA:12776 xref: http://en.wikipedia.org/wiki/Superficial_anterior_cervical_lymph_nodes xref: http://www.snomedbrowser.com/Codes/Details/22993006 is_a: UBERON:0004870 ! superficial cervical lymph node is_a: UBERON:0012307 {source="FMA"} ! anterior cervical lymph node [Term] id: UBERON:0012310 name: deep lateral cervical lymph node namespace: uberon def: "The deep lateral cervical lymph nodes are found near the upper part of the internal jugular vein in the neck, lateral or posterior to the carotid sheath." [http://en.wikipedia.org/wiki/Deep_lateral_cervical_lymph_nodes] synonym: "deep lateral cervical node" EXACT [FMA:12770] xref: FMA:12770 xref: http://en.wikipedia.org/wiki/Deep_lateral_cervical_lymph_nodes xref: http://www.snomedbrowser.com/Codes/Details/61755005 is_a: UBERON:0004722 ! deep cervical lymph node is_a: UBERON:0012306 {source="FMA"} ! lateral cervical lymph node [Term] id: UBERON:0012311 name: deep anterior cervical lymph node namespace: uberon def: "The deep anterior cervical lymph nodes are found near the middle cricothyroid ligament and the trachea." [http://en.wikipedia.org/wiki/Deep_anterior_cervical_lymph_nodes] xref: FMA:12779 xref: http://en.wikipedia.org/wiki/Deep_anterior_cervical_lymph_nodes xref: http://www.snomedbrowser.com/Codes/Details/52363008 is_a: UBERON:0004722 ! deep cervical lymph node is_a: UBERON:0012307 {source="FMA"} ! anterior cervical lymph node [Term] id: UBERON:0012330 name: nasal-associated lymphoid tissue namespace: uberon def: "The lymphocytic cell population present in the mucosa of the nasopharyngeal duct of some animals." [ncithesaurus:Nasal-Associated_Lymphoid_Tissue] synonym: "NALT" EXACT ABBREVIATION [http://en.wikipedia.org/wiki/Mucosa-associated_lymphoid_tissue#Categorisation] synonym: "naso-pharyngeal lymphoid tissue" EXACT [FMA:79771] xref: FMA:79771 xref: http://linkedlifedata.com/resource/umls/id/C2698431 xref: MA:0003030 xref: NCIT:C77659 xref: UMLS:C2698431 {source="ncithesaurus:Nasal-Associated_Lymphoid_Tissue"} is_a: UBERON:0001962 ! gut-associated lymphoid tissue [Term] id: UBERON:0013119 name: haemal node namespace: uberon def: "A lymphoid organ found in various mammals and some birds." [http://en.wikipedia.org/wiki/Haemal_nodes] comment: Hemal nodes are characterized by the presence of large numbers of erythrocytes. Lymph nodes (see below) and hemal nodes share some similarities of structure, but really are fundamentally different organs both qualitatively and quantitatively. Both lymph and hemal nodes contain diffuse lymphatic tissue, and in most cases have nodular tissue in the form of germinal centers, as well. Like the lymph node, the hemal node has a cortex and a medulla, and germinal centers are frequently seen. There's a distinct capsule, and hemal nodes are served at the hilus by an afferent arteriole. [http://www.vetmed.vt.edu/education/curriculum/vm8054/labs/lab13/lab13.htm] synonym: "hemal node" EXACT [] xref: Haemal:nodes is_a: UBERON:0005057 ! immune organ [Term] id: UBERON:0013132 name: penicillar arteriole namespace: uberon def: "One of the small straight arteries of the red pulp of the spleen; a branch of the spleen central artery that supplies the red pulp[WP,modified]" [http://www.merriam-webster.com/medical/penicillus, https://orcid.org/0000-0002-6601-2165] synonym: "penicillar artery" RELATED [] synonym: "penicilli" EXACT PLURAL [http://www.merriam-webster.com/medical/penicilli] synonym: "penicillus" EXACT [FMA:16038] xref: FMA:16038 is_a: UBERON:0010399 ! spleen trabecular artery is_a: UBERON:0022292 ! splenic arteriole relationship: part_of UBERON:0010401 ! spleen central arteriole [Term] id: UBERON:0013478 name: cecal tonsil namespace: uberon def: "A thickened round patch of lymphoid tissue located at the ileocecal junction adjacent to the sacculus rotundus." [ISBN:0824754077] synonym: "caecal tonsil" EXACT [] synonym: "cecal GALT" RELATED [] xref: http://www.snomedbrowser.com/Codes/Details/14239003 is_a: UBERON:0001962 ! gut-associated lymphoid tissue property_value: UBPROP:0000008 "In avians the polycryptic cecal tissue is similar to the mammalian palatine tonsil" xsd:string [Term] id: UBERON:0013688 name: tonsil germinal center namespace: uberon def: "A germinal center that is part of a tonsil." [OBOL:automatic] synonym: "tonsil reaction center" RELATED [CALOHA:TS-1288] xref: CALOHA:TS-1288 is_a: UBERON:0010754 ! germinal center relationship: part_of UBERON:0002372 ! tonsil property_value: IAO:0000116 "consider adding related terms, e.g. secondary lymphoid tissue of tonsil" xsd:string property_value: UBPROP:0000001 "The germinal center or reaction center is the activated center of a lymphoid follicle in secondary lymphoid tissue where B-lymphocytes are stimulated by antigens and helper T cells (T-lymphocytes, helper-inducer) are stimulated to generate memory cells. Here, the germinal center of a tonsil[TS-1288]." xsd:string {source="TS-1288"} [Term] id: UBERON:0013689 name: appendix lymphoid tissue namespace: uberon def: "Lymphoid tissue located in the appendix." [CALOHA:TS-1268] synonym: "appendix lymphoid" RELATED [CALOHA:TS-1268] synonym: "lymphatic tissue of appendix" EXACT [OBOL:automatic] synonym: "lymphatic tissue of vermiform appendix" EXACT [OBOL:automatic] xref: CALOHA:TS-1268 is_a: UBERON:0001744 ! lymphoid tissue [Term] id: UBERON:0013696 name: tonsil epithelium namespace: uberon def: "The epithelium that forms the surface of the tonsil dips into the underlying connective tissue in numerous places, forming crypts kown as tonsillar crypts. Stratified squamous epithelium, that may be heavily infiltrated by lymphocytes. Epithelial cells are present in the germinal as well as in the periphery of the nodule." [CALOHA:TS-2070] synonym: "epithelium of tonsil" RELATED [CALOHA:TS-2070] synonym: "tonsil epithelial cell" RELATED [CALOHA:TS-2070] xref: CALOHA:TS-2070 relationship: part_of UBERON:0002372 ! tonsil [Term] id: UBERON:0014779 name: liver reticuloendothelial system namespace: uberon def: "A reticuloendothelial system that is part of a liver." [OBOL:automatic] xref: BTO:0000831 is_a: UBERON:0000363 ! reticuloendothelial system [Term] id: UBERON:0015453 name: subcutaneous lymph node namespace: uberon def: "A lymph node that is part of a hypodermis." [OBOL:automatic] xref: MA:0003028 is_a: UBERON:0000029 ! lymph node [Term] id: UBERON:0015469 name: splenic lymph node namespace: uberon def: "The splenic lymph nodes (or pancreaticolienal) accompany the lienal (splenic) artery, and are situated in relation to the posterior surface and upper border of the pancreas; one or two members of this group are found in the gastrolienal ligament. Their afferents are derived from the stomach, spleen, and pancreas, their efferents join the celiac group of preaortic glands." [http://en.wikipedia.org/wiki/Splenic_lymph_nodes] synonym: "jPS 10 node" RELATED [FMA:66187] synonym: "jPS no. 10 node" RELATED [FMA:66187] synonym: "lymph node of splenic hilum" RELATED [FMA:66187] synonym: "no. 10 pancreaticosplenic lymph node" RELATED [FMA:66187] synonym: "pancreaticolienal lymph node" RELATED [http://en.wikipedia.org/wiki/Splenic_lymph_nodes] synonym: "splenic glands" RELATED [http://en.wikipedia.org/wiki/Splenic_lymph_nodes] xref: FMA:66187 xref: http://en.wikipedia.org/wiki/Splenic_lymph_nodes xref: http://www.snomedbrowser.com/Codes/Details/80088008 xref: MA:0003074 is_a: UBERON:0000029 {source="MA"} ! lymph node [Term] id: UBERON:0015472 name: tracheobronchial lymph node namespace: uberon alt_id: UBERON:0016381 def: "A lymph node located near the bifurcation of the trachea." [ncithesaurus:Tracheobronchial_Lymph_Node] synonym: "bronchial lymph node" NARROW [MA:0003078] synonym: "lymph node, tracheobronchial" RELATED [] synonym: "nodus tracheobronchiale lymphaticus" EXACT [FMA:5950] synonym: "tracheobronchal lymph node" EXACT [http://www.ncbi.nlm.nih.gov/pubmed/16624319] synonym: "tracheobronchal node" EXACT [http://www.ncbi.nlm.nih.gov/pubmed/16624319] synonym: "tracheobronchial node" EXACT [FMA:5950] xref: FMA:5950 xref: http://en.wikipedia.org/wiki/Tracheobronchial_lymph_nodes xref: http://linkedlifedata.com/resource/umls/id/C0229751 xref: http://www.snomedbrowser.com/Codes/Details/245341003 xref: MA:0003068 xref: NCIT:C77651 is_a: UBERON:0007644 ! thoracic lymph node property_value: UBPROP:0000001 "Single (unpaired) lymph node at the tracheal bifurcation." xsd:string {source="http://www.ncbi.nlm.nih.gov/pubmed/16624319", taxon="NCBITaxon:10090"} [Term] id: UBERON:0015857 name: parotid lymph node namespace: uberon def: "A lymph node found near the parotid gland." [http://en.wikipedia.org/wiki/Parotid_lymph_nodes] synonym: "parotid node" EXACT [FMA:61216] xref: FMA:61216 xref: http://en.wikipedia.org/wiki/Parotid_lymph_nodes xref: http://www.snomedbrowser.com/Codes/Details/279140007 xref: MA:0003088 is_a: UBERON:0015870 ! lymph node of head [Term] id: UBERON:0015859 name: hepatic lymph node namespace: uberon def: "Any of the lymph nodes adjacent to the stomach and duodenum." [ncithesaurus:Hepatic_Lymph_Node] synonym: "hepatic node" EXACT [FMA:12798] synonym: "lymphoglandulae hepaticae" EXACT LATIN [http://en.wikipedia.org/wiki/Hepatic_lymph_nodes] synonym: "lymphoglandulæ hepaticæ" EXACT LATIN [http://en.wikipedia.org/wiki/Hepatic_lymph_nodes] synonym: "nodi lymphoidei hepatici" EXACT LATIN [http://en.wikipedia.org/wiki/Hepatic_lymph_nodes] synonym: "portal lymph node" EXACT [FMA:12798] xref: FMA:12798 xref: http://en.wikipedia.org/wiki/Hepatic_lymph_nodes xref: http://linkedlifedata.com/resource/umls/id/C0229769 xref: http://www.snomedbrowser.com/Codes/Details/280480005 xref: MA:0003072 xref: NCIT:C77640 is_a: UBERON:0015860 {source="FMA"} ! visceral abdominal lymph node [Term] id: UBERON:0015860 name: visceral abdominal lymph node namespace: uberon xref: FMA:66178 is_a: UBERON:0002507 {source="FMA"} ! abdominal lymph node [Term] id: UBERON:0015863 name: gastric lymph node namespace: uberon def: "A lymph node along the left gastric artery or greater omentum." [ncithesaurus:Gastric_Lymph_Node] synonym: "gastric node" EXACT [FMA:12796] synonym: "nodi lymphoidei gastrici" EXACT LATIN [http://en.wikipedia.org/wiki/Gastric_lymph_nodes] xref: FMA:12796 xref: http://en.wikipedia.org/wiki/Gastric_lymph_nodes xref: http://linkedlifedata.com/resource/umls/id/C1282334 xref: MA:0003071 xref: NCIT:C92222 is_a: UBERON:0015860 {source="FMA"} ! visceral abdominal lymph node property_value: UBPROP:0000001 "Single (unpaired) lymph node in the lesser omentum at the minor curvature of the stomach" xsd:string {source="http://www.ncbi.nlm.nih.gov/pubmed/16624319", taxon="NCBITaxon:10090"} [Term] id: UBERON:0015865 name: pancreaticosplenic lymph node namespace: uberon def: "lymph nodes of the pancreatic tail and spleen, receiving afferents from both organs plus the greater curvature of the stomach; they drain to the celiac lymph nodes." [http://medical-dictionary.thefreedictionary.com/pancreaticosplenic+lymph+nodes] synonym: "nodi lymphatici panoccidianuperiores" RELATED [http://medical-dictionary.thefreedictionary.com/pancreaticosplenic+lymph+nodes] synonym: "nodi lymphoidei pancreaticolienales" RELATED [http://medical-dictionary.thefreedictionary.com/pancreaticosplenic+lymph+nodes] synonym: "nodi lymphoidei pancreaticosplenales" RELATED [http://medical-dictionary.thefreedictionary.com/pancreaticosplenic+lymph+nodes] synonym: "pancreaticosplenic node" EXACT [FMA:12799] synonym: "superior pancreatic lymph nodes" RELATED [http://medical-dictionary.thefreedictionary.com/pancreaticosplenic+lymph+nodes] synonym: "superior pancreatic node" RELATED [FMA:12799] synonym: "superior pancreaticosplenic lymph node" RELATED [FMA:12799] xref: FMA:12799 xref: http://www.snomedbrowser.com/Codes/Details/280723006 is_a: UBERON:0015860 {source="FMA"} ! visceral abdominal lymph node property_value: IAO:0000116 "Consider obsoleting - this is apparently an obsolete term that regarded the pancreatic and splenic lymph nodes as a single anatomic unit.[http://medical-dictionary.thefreedictionary.com/pancreaticosplenic+lymph+nodes]" xsd:string [Term] id: UBERON:0015866 name: pyloric lymph node namespace: uberon synonym: "pyloric node" EXACT [FMA:12802] xref: FMA:12802 xref: http://www.snomedbrowser.com/Codes/Details/280127001 is_a: UBERON:0015860 {source="FMA"} ! visceral abdominal lymph node [Term] id: UBERON:0015867 name: cystic lymph node namespace: uberon synonym: "cystic node" EXACT [FMA:12804] xref: FMA:12804 xref: http://www.snomedbrowser.com/Codes/Details/46081008 is_a: UBERON:0015860 {source="FMA"} ! visceral abdominal lymph node [Term] id: UBERON:0015868 name: lymph node of epiploic foramen namespace: uberon synonym: "epiploic foramen lymph node" RELATED [FMA:12805] synonym: "lymph node of anterior border of epiploic foramen" EXACT [FMA:12805] synonym: "lymph node of anterior border of omental foramen" EXACT [FMA:12805] synonym: "node of anterior border of epiploic foramen" EXACT [FMA:12805] synonym: "node of anterior border of omental foramen" EXACT [FMA:12805] synonym: "nodus foraminalis" EXACT LATIN [FMA:12805, FMA:TA] synonym: "nodus lymphoideus foraminalis" EXACT LATIN [FMA:12805, FMA:TA] xref: FMA:12805 is_a: UBERON:0015860 {source="FMA"} ! visceral abdominal lymph node [Term] id: UBERON:0015869 name: retropharyngeal lymph node namespace: uberon def: "The retropharyngeal lymph nodes, from one to three in number, lie in the buccopharyngeal fascia, behind the upper part of the pharynx and in front of the arch of the atlas, being separated, however, from the latter by the Longus capitis. Their afferents drain the nasal cavities, the nasal part of the pharynx, and the auditory tubes. Their efferents pass to the superior deep cervical glands. They are in the retropharyngeal space." [http://en.wikipedia.org/wiki/Retropharyngeal_lymph_nodes] synonym: "retropharyngeal glands" RELATED [http://en.wikipedia.org/wiki/Retropharyngeal_lymph_nodes] synonym: "retropharyngeal lymph node" RELATED [http://en.wikipedia.org/wiki/Retropharyngeal_lymph_nodes] synonym: "retropharyngeal node" EXACT [FMA:61237] xref: EMAPA:37724 {source="MA:th"} xref: FMA:61237 xref: http://en.wikipedia.org/wiki/Retropharyngeal_lymph_nodes xref: http://linkedlifedata.com/resource/umls/id/C0229737 xref: http://www.snomedbrowser.com/Codes/Details/167263004 xref: MA:0003070 xref: NCIT:C77649 is_a: UBERON:0012311 {source="FMA"} ! deep anterior cervical lymph node [Term] id: UBERON:0015870 name: lymph node of head namespace: uberon def: "A lymph node that is part of a head." [OBOL:automatic] xref: FMA:61212 xref: http://www.snomedbrowser.com/Codes/Details/155136006 is_a: UBERON:0000029 ! lymph node [Term] id: UBERON:0015871 name: facial lymph node namespace: uberon def: "Any of the lymph nodes that are part of a face." [http://en.wikipedia.org/wiki/Facial_lymph_nodes, http://www.bartleby.com/107/177.html] synonym: "buccal lymph node" EXACT [FMA:61222] xref: FMA:61222 xref: http://en.wikipedia.org/wiki/Facial_lymph_nodes xref: http://www.snomedbrowser.com/Codes/Details/279139005 is_a: UBERON:0015870 ! lymph node of head property_value: UBPROP:0000008 "In humans, these comprise three groups: (a) infraorbital or maxillary, scattered over the infraorbital region from the groove between the nose and cheek to the zygomatic arch; (b) buccinator, one or more placed on the Buccinator opposite the angle of the mouth; (c) supramandibular, on the outer surface of the mandible, in front of the Masseter and in contact with the external maxillary artery and anterior facial vein." xsd:string [Term] id: UBERON:0015872 name: mandibular lymph node namespace: uberon def: "The mandibular lymph node is a lymph node found near the jaw." [http://en.wikipedia.org/wiki/Mandibular_lymph_node] comment: Editor nodes: consider merging with submandibular, at least for mouse, see http://www.ncbi.nlm.nih.gov/pubmed/16624319 synonym: "lymphonodi mandibulares" RELATED LATIN [http://en.wikipedia.org/wiki/Mandibular_lymph_node] synonym: "mandibular node" EXACT [FMA:61227] synonym: "nodus lymphoideus mandibularis" RELATED LATIN [http://en.wikipedia.org/wiki/Mandibular_lymph_node] synonym: "nodus mandibularis" EXACT [FMA:TA] xref: FMA:61227 xref: http://en.wikipedia.org/wiki/Mandibular_lymph_node xref: http://www.snomedbrowser.com/Codes/Details/10664000 xref: MA:0003067 is_a: UBERON:0015871 {source="FMA"} ! facial lymph node property_value: UBPROP:0000001 "In mice, Rostromedial to the sublingual and mandibular salivary glands." xsd:string {source="http://www.ncbi.nlm.nih.gov/pubmed/16624319", taxon="NCBITaxon:10090"} [Term] id: UBERON:0015876 name: pelvic lymph node namespace: uberon def: "Any lymph node within the abdominal pelvic region." [ncithesaurus:Pelvic_Lymph_Node] synonym: "lymph node of pelvis" EXACT [FMA:12800] synonym: "pelvic node" RELATED [] xref: FMA:12800 xref: http://linkedlifedata.com/resource/umls/id/C0729595 xref: http://www.snomedbrowser.com/Codes/Details/245352009 xref: NCIT:C12363 is_a: UBERON:0000029 ! lymph node [Term] id: UBERON:0015877 name: parietal pelvic lymph node namespace: uberon synonym: "paracervical lymph node" RELATED [FMA:66193] xref: FMA:66193 is_a: UBERON:0015876 {source="FMA"} ! pelvic lymph node [Term] id: UBERON:0015878 name: common iliac lymph node namespace: uberon def: "The external iliac lymph nodes, from eight to ten in number, lie along the external iliac vessels. They are arranged in three groups, one on the lateral, another on the medial, and a third on the anterior aspect of the vessels; the third group is, however, sometimes absent. Their principal afferents are derived from the inguinal lymph nodes, the deep lymphatics of the abdominal wall below the umbilicus and of the adductor region of the thigh, and the lymphatics from the glans penis vel clitoridis, the membranous urethra, the prostate, the fundus of the urinary bladder, the cervix uteri, and upper part of the vagina." [http://en.wikipedia.org/wiki/External_iliac_lymph_nodes] synonym: "common iliac node" EXACT [FMA:12806] synonym: "external iliac glands" RELATED [http://en.wikipedia.org/wiki/External_iliac_lymph_nodes] synonym: "external iliac lymph gland" RELATED [http://en.wikipedia.org/wiki/External_iliac_lymph_nodes] synonym: "iliac lymph node" EXACT [FMA:12806] synonym: "iliac lymph node" RELATED [http://en.wikipedia.org/wiki/External_iliac_lymph_nodes] synonym: "noduli iliaci superficiales" RELATED LATIN [http://en.wikipedia.org/wiki/External_iliac_lymph_nodes] xref: FMA:12806 xref: http://en.wikipedia.org/wiki/External_iliac_lymph_nodes xref: http://linkedlifedata.com/resource/umls/id/C0229807 xref: http://www.snomedbrowser.com/Codes/Details/314889004 xref: MA:0003066 xref: NCIT:C32761 is_a: UBERON:0015877 {source="FMA"} ! parietal pelvic lymph node [Term] id: UBERON:0015880 name: external iliac lymph node namespace: uberon synonym: "external iliac node" EXACT [FMA:16646] xref: FMA:16646 xref: http://linkedlifedata.com/resource/umls/id/C0229815 xref: http://www.snomedbrowser.com/Codes/Details/245358008 xref: NCIT:C88143 is_a: UBERON:0015877 {source="FMA"} ! parietal pelvic lymph node [Term] id: UBERON:0015881 name: internal iliac lymph node namespace: uberon def: "The internal iliac lymph nodes (or hypogastric) surround the internal iliac artery and its branches (the hypogastric vessels), and receive the lymphatics corresponding to the distribution of the branches of it, i. e. , they receive lymphatics from all the pelvic viscera, from the deeper parts of the perineum, including the membranous and cavernous portions of the urethra, and from the buttock and back of the thigh. It does not receive lymph from the ovary, testis, or superior half of the rectum; the gonads drain to the paraaortic lymph nodes, while the superior half of the rectum drains to the pararectal lymph nodes." [http://en.wikipedia.org/wiki/Internal_iliac_lymph_nodes] synonym: "internal iliac node" EXACT [FMA:16654] xref: FMA:16654 xref: http://en.wikipedia.org/wiki/Internal_iliac_lymph_nodes xref: http://linkedlifedata.com/resource/umls/id/C0447192 xref: http://www.snomedbrowser.com/Codes/Details/245357003 xref: NCIT:C88142 is_a: UBERON:0015877 {source="FMA"} ! parietal pelvic lymph node [Term] id: UBERON:0015883 name: gluteal lymph node namespace: uberon synonym: "gluteal node" EXACT [FMA:16657] xref: FMA:16657 xref: http://www.snomedbrowser.com/Codes/Details/276154000 is_a: UBERON:0015877 {source="FMA"} ! parietal pelvic lymph node [Term] id: UBERON:0015884 name: presymphysial lymph node namespace: uberon synonym: "presymphysial node" EXACT [FMA:16667] xref: FMA:16667 xref: http://www.snomedbrowser.com/Codes/Details/279448009 is_a: UBERON:0015877 {source="FMA"} ! parietal pelvic lymph node [Term] id: UBERON:0015895 name: proximal deep inguinal lymph node namespace: uberon def: "One of the deep inguinal lymph nodes located in or adjacent to the femoral canal; sometimes mistaken for a femoral hernia when enlarged." [BTO:0004550] synonym: "node of Cloquet" RELATED [BTO:0004550] synonym: "nodus inguinales profundi proximalis" EXACT [FMA:TA] synonym: "nodus lymphoideus inguinales profundi proximalis" EXACT LATIN [FMA:44303, FMA:TA] synonym: "nodus lymphoideus inguinalis profundi proximalis" RELATED [BTO:0004550] synonym: "proximal deep inguinal node" EXACT [FMA:44303] synonym: "proximal inguinal lymph node" EXACT [FMA:44303] synonym: "Rosenmueller gland" RELATED [BTO:0004550] synonym: "Rosenmueller node" RELATED [BTO:0004550] synonym: "rosenmuller's gland" EXACT [FMA:44303] synonym: "rosenmuller's node" EXACT [FMA:44303] xref: BTO:0004550 xref: FMA:44303 is_a: UBERON:0009006 {source="FMA"} ! deep inguinal lymph node [Term] id: UBERON:0015917 name: superficial lymph node namespace: uberon def: "A lymph node that is located close to the surface." [http://orcid.org/0000-0002-6601-2165] xref: FMA:12767 xref: NCIT:C102716 is_a: UBERON:0000029 ! lymph node [Term] id: UBERON:0015918 name: deep lymph node namespace: uberon def: "A lymph node that is located deeper within the organism, further from the surface." [http://orcid.org/0000-0002-6601-2165] xref: FMA:12768 is_a: UBERON:0000029 ! lymph node [Term] id: UBERON:0015922 name: accessory mandibular lymph node namespace: uberon is_a: UBERON:0015871 ! facial lymph node property_value: UBPROP:0000001 "Dorsolateral to the mandibular lymph node." xsd:string {source="http://www.ncbi.nlm.nih.gov/pubmed/16624319", taxon="NCBITaxon:10090"} [Term] id: UBERON:0015923 name: superficial parotid lymph node namespace: uberon def: "A parotid lymph node that is located superficially." [http://orcid.org/0000-0002-6601-2165] synonym: "superficial parotid node" EXACT [FMA:61217] xref: FMA:61217 xref: http://en.wikipedia.org/wiki/Superficial_parotid_lymph_nodes xref: http://www.snomedbrowser.com/Codes/Details/279141006 is_a: UBERON:0015857 ! parotid lymph node is_a: UBERON:0015917 ! superficial lymph node property_value: UBPROP:0000001 "Rostromedial to the sublingual and mandibular salivary glands Dorsolateral to the mandibular lymph node Ventral to the external acoustic pore, caudal to the extraorbital lacrimal gland, cranioventral to the parotid salivary gland, dorsal to the junction between the superficial temporal vein (v.) and the maxillary v.." xsd:string {source="http://www.ncbi.nlm.nih.gov/pubmed/16624319", taxon="NCBITaxon:10090"} [Term] id: UBERON:0015925 name: superficial intraparotid lymph node namespace: uberon synonym: "superficial intraparotid node" EXACT [] xref: http://www.snomedbrowser.com/Codes/Details/68339009 is_a: UBERON:0015917 ! superficial lymph node is_a: UBERON:0035080 ! intraparotid lymph node [Term] id: UBERON:0015926 name: cranial deep lymph node namespace: uberon synonym: "cranial deep node" EXACT [] is_a: UBERON:0015870 ! lymph node of head property_value: UBPROP:0000001 "Medial to the external jugular vein and sternocephalic muscle (m.), lateral to sternohyoid m., caudal to digastric m., dorsal to the trachea." xsd:string {source="http://www.ncbi.nlm.nih.gov/pubmed/16624319", taxon="NCBITaxon:10090"} [Term] id: UBERON:0016374 name: sciatic lymph node namespace: uberon def: "A lymph node that is medial to the gluteus superficialis m., caudal to gluteus medius m. and sciatic nerve lymph node" [http://www.ncbi.nlm.nih.gov/pubmed/16624319] xref: MA:0002884 is_a: UBERON:0016398 ! lymph node of lower limb property_value: RO:0002175 NCBITaxon:10090 {source="http://www.ncbi.nlm.nih.gov/pubmed/16624319"} [Term] id: UBERON:0016378 name: ileocolic lymph node namespace: uberon def: "One of the lymph nodes that form a chain around the ileocolic artery." [http://en.wikipedia.org/wiki/Ileocolic_lymph_nodes] synonym: "ileocecocolic lymph node" NARROW [MA:0003065, ncithesaurus:Ileocecocolic_Lymph_Node] synonym: "ileocolic node" RELATED [FMA:16611] synonym: "nodi lymphoidei ileocolici" EXACT LATIN [http://en.wikipedia.org/wiki/Ileocolic_lymph_nodes] xref: FMA:16611 xref: http://en.wikipedia.org/wiki/Ileocolic_lymph_nodes xref: http://linkedlifedata.com/resource/umls/id/C2697661 xref: http://www.snomedbrowser.com/Codes/Details/29180003 xref: MA:0003065 xref: NCIT:C77653 is_a: UBERON:0000029 {source="MA"} ! lymph node property_value: IAO:0000116 "Can be subclassed based on position relative to terminal branches of the vessel. Consider adding subclasses for these: (a) ileal, in relation to the ileal branch of the artery;(b) anterior ileocolic, usually of three glands, in the ileocolic fold, near the wall of the cecum;(c) posterior ileocolic, mostly placed in the angle between the ileum and the colon, but partly lying behind the cecum at its junction with the ascending colon;(d) a single gland, between the layers of the mesenteriole of the vermiform process;(e) right colic, along the medial side of the ascending colon." xsd:string property_value: UBPROP:0000001 "A lymph node at the ileocecocolic junction." xsd:string {source="ncithesaurus:Ileocecocolic_Lymph_Node"} [Term] id: UBERON:0016382 name: prescapular lymph node namespace: uberon xref: EMAPA:37723 {source="MA:th"} xref: MA:0003069 xref: NCIT:C77654 is_a: UBERON:0002429 {source="MA"} ! cervical lymph node [Term] id: UBERON:0016386 name: paraaortic lymph node namespace: uberon def: "The paraaortic lymph nodes (also known as para-aortic, periaortic, and peri-aortic) are a group of lymph nodes that lie in front of the lumbar vertebral bodies near the aorta. These lymph nodes receive drainage from the lower gastrointestinal tract and the pelvic organs." [http://en.wikipedia.org/wiki/Paraaortic_lymph_node] synonym: "lateral aortic lymph node" EXACT [FMA:16604] synonym: "lateral aortic node" EXACT [FMA:16604] synonym: "latero-aortic lymph node" RELATED [FMA:16604] synonym: "lateroaortic lymph node" RELATED [FMA:16604] synonym: "left lateral aortic lymph node" RELATED [FMA:16604] synonym: "para-aortic lymph node" EXACT [FMA:16604] xref: FMA:16604 xref: http://en.wikipedia.org/wiki/Paraaortic_lymph_node xref: MA:0003073 xref: NCIT:C77643 is_a: UBERON:0000029 {source="MA"} ! lymph node [Term] id: UBERON:0016390 name: auricular lymph node namespace: uberon xref: MA:0003092 is_a: UBERON:0000029 {source="MA"} ! lymph node property_value: RO:0002174 NCBITaxon:10090 {source="http://www.ncbi.nlm.nih.gov/pubmed/16624319"} [Term] id: UBERON:0016391 name: thymic lymph node namespace: uberon xref: MA:0003118 is_a: UBERON:0000029 {source="MA"} ! lymph node [Term] id: UBERON:0016392 name: mastoid lymph node namespace: uberon def: "The mastoid lymph nodes (retroauricular lymph nodes, posterior auricular glands), usually two in number, are situated on the mastoid insertion of the Sternocleidomastoideus, beneath the Auricularis posterior. Their afferent vessels drain the posterior part of the temporoparietal region, the upper part of the cranial surface of the auricula or pinna, and the back of the external acoustic meatus; their efferents pass to the superior deep cervical glands." [http://en.wikipedia.org/wiki/Mastoid_lymph_nodes] synonym: "mastoid glands" RELATED [http://en.wikipedia.org/wiki/Mastoid_lymph_nodes] synonym: "mastoid node" EXACT [FMA:61215] synonym: "postauricular lymph node" EXACT [UBERON:cjm] synonym: "posterior auricular glands" RELATED [http://en.wikipedia.org/wiki/Mastoid_lymph_nodes] synonym: "retro-auricular lymph node" EXACT [FMA:61215] synonym: "retro-auricular node" EXACT [FMA:61215] synonym: "retroauricular lymph nodes" RELATED [http://en.wikipedia.org/wiki/Mastoid_lymph_nodes] xref: FMA:61215 xref: http://en.wikipedia.org/wiki/Mastoid_lymph_nodes xref: http://www.snomedbrowser.com/Codes/Details/245328002 xref: http://www.snomedbrowser.com/Codes/Details/279143009 is_a: UBERON:0015870 {source="FMA"} ! lymph node of head [Term] id: UBERON:0016393 name: deep parotid lymph node namespace: uberon def: "The deep parotid lymph nodes are lymph nodes found below the parotid gland. The afferents of the subparotid glands drain the nasal part of the pharynx and the posterior parts of the nasal cavities. Their efferents pass to the superior deep cervical glands." [http://en.wikipedia.org/wiki/Deep_parotid_lymph_nodes] synonym: "deep parotid node" EXACT [FMA:61218] xref: FMA:61218 xref: http://en.wikipedia.org/wiki/Deep_parotid_lymph_nodes xref: http://www.snomedbrowser.com/Codes/Details/279142004 is_a: UBERON:0015857 {source="FMA"} ! parotid lymph node is_a: UBERON:0015918 ! deep lymph node [Term] id: UBERON:0016394 name: anterior auricular lymph node namespace: uberon def: "The preauricular deep parotid lymph nodes (anterior auricular glands or preauricular glands), from one to three in number, lie immediately in front of the tragus. Their afferents drain the lateral surface of the auricula and the skin of the adjacent part of the temporal region; their efferents pass to the superior deep cervical glands." [http://en.wikipedia.org/wiki/Preauricular_deep_parotid_lymph_nodes] synonym: "anterior auricular glands" RELATED [http://en.wikipedia.org/wiki/Preauricular_deep_parotid_lymph_nodes] synonym: "pre-auricular lymph node" EXACT [FMA:61219] synonym: "pre-auricular lymph nodes" RELATED [http://en.wikipedia.org/wiki/Preauricular_deep_parotid_lymph_nodes] synonym: "pre-auricular node" EXACT [FMA:61219] synonym: "preauricular glands" RELATED [http://en.wikipedia.org/wiki/Preauricular_deep_parotid_lymph_nodes] synonym: "preauricular lymph node" EXACT [] synonym: "preauricular node" EXACT [FMA:61219] xref: FMA:61219 xref: http://en.wikipedia.org/wiki/Preauricular_deep_parotid_lymph_nodes xref: http://www.snomedbrowser.com/Codes/Details/245327007 xref: NCIT:C103429 is_a: UBERON:0016393 {source="FMA"} ! deep parotid lymph node property_value: RO:0002174 NCBITaxon:10090 {source="http://www.ncbi.nlm.nih.gov/pubmed/16624319"} [Term] id: UBERON:0016395 name: infra-auricular lymph node namespace: uberon def: "The infra-auricular deep parotid lymph nodes are a group of lymph nodes found underneath the ear." [http://en.wikipedia.org/wiki/Infra-auricular_deep_parotid_lymph_nodes] synonym: "infra-auricular deep node" EXACT [] synonym: "infra-auricular deep parotid lymph node" EXACT [] synonym: "infra-auricular deep parotid node" EXACT [] synonym: "infra-auricular node" EXACT [FMA:61220] xref: FMA:61220 xref: http://en.wikipedia.org/wiki/Infra-auricular_deep_parotid_lymph_nodes xref: http://www.snomedbrowser.com/Codes/Details/22509006 is_a: UBERON:0016393 {source="FMA"} ! deep parotid lymph node [Term] id: UBERON:0016396 name: intraglandular lymph node namespace: uberon synonym: "intraglandular node" EXACT [FMA:61221] xref: FMA:61221 is_a: UBERON:0016393 {source="FMA"} ! deep parotid lymph node [Term] id: UBERON:0016397 name: submental lymph node namespace: uberon def: "The submental lymph nodes (or suprahyoid) are situated between the anterior bellies of the Digastrici. Their afferents drain the central portions of the lower lip and floor of the mouth and the apex of the tongue. Their efferents pass partly to the submandibular lymph nodes and partly to a gland of the deep cervical group situated on the internal jugular vein at the level of the cricoid cartilage." [http://en.wikipedia.org/wiki/Submental_lymph_nodes] synonym: "level Ia neck node" EXACT [FMA:61229] synonym: "submental glands" RELATED [http://en.wikipedia.org/wiki/Submental_lymph_nodes] synonym: "submental node" EXACT [FMA:61229] synonym: "suprahyoid glands" RELATED [http://en.wikipedia.org/wiki/Submental_lymph_nodes] xref: FMA:61229 xref: http://en.wikipedia.org/wiki/Submental_lymph_nodes xref: http://www.snomedbrowser.com/Codes/Details/245318006 is_a: UBERON:0015870 {source="FMA"} ! lymph node of head property_value: RO:0002174 NCBITaxon:10090 {source="http://www.ncbi.nlm.nih.gov/pubmed/16624319"} [Term] id: UBERON:0016398 name: lymph node of lower limb namespace: uberon def: "A lymph node that is part of a hindlimb." [OBOL:automatic] xref: FMA:44310 xref: http://www.snomedbrowser.com/Codes/Details/361109000 is_a: UBERON:0000029 ! lymph node [Term] id: UBERON:0016399 name: lymph node of upper limb namespace: uberon def: "A lymph node that is part of a forelimb." [OBOL:automatic] xref: FMA:44311 xref: http://www.snomedbrowser.com/Codes/Details/276155004 is_a: UBERON:0000029 ! lymph node [Term] id: UBERON:0016401 name: pancreaticoduodenal lymph node namespace: uberon synonym: "pancreaticoduodenal node" EXACT [FMA:16623] xref: FMA:16623 xref: http://www.snomedbrowser.com/Codes/Details/281152007 is_a: UBERON:0015860 {source="FMA"} ! visceral abdominal lymph node property_value: RO:0002175 NCBITaxon:10090 {source="http://www.ncbi.nlm.nih.gov/pubmed/16624319"} property_value: UBPROP:0000001 "Single (unpaired) lymph node in the mesoduodenum, dorsal to the portal vein, surrounded by pancreatic tissue" xsd:string {source="http://www.ncbi.nlm.nih.gov/pubmed/16624319", taxon="NCBITaxon:10090"} [Term] id: UBERON:0016402 name: mesocolic lymph node namespace: uberon xref: FMA:300965 xref: http://en.wikipedia.org/wiki/Mesocolic_lymph_nodes is_a: UBERON:0039168 {source="FMA"} ! colic lymph node property_value: RO:0002175 NCBITaxon:10090 {source="http://www.ncbi.nlm.nih.gov/pubmed/16624319"} property_value: UBPROP:0000001 "Colic lymph node: A mesocolic lymph node that is located along the arteries supplying the colon" xsd:string {source="http://en.wikipedia.org/wiki/Mesocolic_lymph_nodes"} property_value: UBPROP:0000001 "colic lymph nodes: those mesocolic lymph nodes located along the arteries supplying the colon." xsd:string {source="http://www.medilexicon.com"} property_value: UBPROP:0000001 "In the mesocolon at the transition between ascending colon and transverse colon" xsd:string {source="http://www.ncbi.nlm.nih.gov/pubmed/16624319", taxon="NCBITaxon:10090"} property_value: UBPROP:0000001 "mesocolic lymph nodes: nodes located in the mesocolon; they are of two classes: paracolic lymph nodes, located in immediate proximity to the colon; colic lymph nodes located along the arteries supplying the colon." xsd:string {source="http://www.medilexicon.com"} [Term] id: UBERON:0016481 name: bronchial lymph node namespace: uberon def: "A lymph node that is part of a bronchus." [OBOL:automatic] xref: http://linkedlifedata.com/resource/umls/id/C1305372 xref: MA:0003078 xref: NCIT:C32232 is_a: UBERON:0000029 ! lymph node [Term] id: UBERON:0018226 name: pulmonary part of lymphatic system namespace: uberon def: "An organ system subdivision that is the part of the lymphoid system that includes the pulmonary lymphatic vessels." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "pulmonary lymphatic chain" EXACT [FMA:67999] synonym: "pulmonary lymphatic vasculature" RELATED [] xref: FMA:67999 relationship: part_of UBERON:0006558 ! lymphatic part of lymphoid system [Term] id: UBERON:0018227 name: pulmonary lymphatic vessel namespace: uberon def: "A lymphatic vessel that is part of a lung." [OBOL:automatic] synonym: "lymphatic vessel of lung" EXACT [] xref: FMA:234006 xref: http://www.snomedbrowser.com/Codes/Details/321862009 is_a: UBERON:0003456 ! respiratory system lymphatic vessel relationship: part_of UBERON:0018226 ! pulmonary part of lymphatic system [Term] id: UBERON:0018244 name: superficial cervical thymus namespace: uberon def: "A cervical thymus that is located directly beneath the skin." [https://doi.org/10.1071/ZO9730285] is_a: UBERON:0009114 ! cervical thymus property_value: RO:0002175 NCBITaxon:9263 property_value: UBPROP:0000008 "apparently absent in polyprotodont species (Didelphidae, Dasyuridae, Thylacinidae, Notoryctidae, Peramelidae, and Caenolestidae); paired lobes found in diprotodont (Burramyidae, Petauridae, Phalangeridae, Phascolarctidae, and Tarsipedidae)[DOI:10.1071/ZO9730285]" xsd:string [Term] id: UBERON:0018245 name: deep cervical thymus namespace: uberon def: "A cervical thymus that is located deep in the ventral cervical region, superficial to hyoid, sternomastoid, and depressor neck muscles." [https://doi.org/10.1071/ZO9730285] is_a: UBERON:0009114 ! cervical thymus [Term] id: UBERON:0018410 name: lacteal namespace: uberon def: "a lymphatic capillary that absorbs dietary fats in the villi of the small intestine." [http://en.wikipedia.org/wiki/Lacteals] xref: FMA:68443 xref: http://en.wikipedia.org/wiki/Lacteals xref: http://www.snomedbrowser.com/Codes/Details/282414002 is_a: UBERON:0006842 ! lymphatic capillary [Term] id: UBERON:0022292 name: splenic arteriole namespace: uberon xref: http://www.snomedbrowser.com/Codes/Details/282511007 xref: NCIT:C33596 relationship: part_of UBERON:0002106 ! spleen [Term] id: UBERON:0034949 name: lymphatic valve namespace: uberon synonym: "lymphatic vessel valve" EXACT [FMA:68454] xref: FMA:68454 relationship: part_of UBERON:0001473 ! lymphatic vessel [Term] id: UBERON:0034950 name: lymph sac of lymph heart namespace: uberon def: "An extensive dorsal subcutaneous sac that opens into a lymph heart." [https://github.com/obophenotype/uberon/issues/1383, https://www.merriam-webster.com/dictionary/lymph%20sac] is_a: UBERON:0001473 ! lymphatic vessel property_value: UBPROP:0000008 "The anuran lymphatic system consists of extensive subcutaneous and intrapleuroperitoneal sacs separated by connective tissue walls and interconnected by one-way valves [DOI:10.1152/japplphysiol.00201.2013]" xsd:string [Term] id: UBERON:0034951 name: subcutaneous lymph sac namespace: uberon xref: http://www.snomedbrowser.com/Codes/Details/330419002 is_a: UBERON:0034950 ! lymph sac of lymph heart property_value: RO:0002175 NCBITaxon:8342 [Term] id: UBERON:0034952 name: intrapleuroperitoneal lymph sac namespace: uberon is_a: UBERON:0034950 ! lymph sac of lymph heart [Term] id: UBERON:0034953 name: embryonic lymph sac namespace: uberon def: "A population of lymphatic endothelial cell precursors that will form the lymph vessels." [https://doi.org/10.1152/japplphysiol.00201.2013, https://github.com/obophenotype/uberon/issues/1383] synonym: "primary lymph sac" RELATED [] xref: http://linkedlifedata.com/resource/umls/id/C1514424 xref: NCIT:C34262 relationship: part_of UBERON:0006558 {source="VHOG"} ! lymphatic part of lymphoid system [Term] id: UBERON:0034958 name: retroperitoneal embryonic lymph sac namespace: uberon def: "An embryonic lymph sac that forms in the root of the mesentery on the posterior abdominal wall" [https://discovery.lifemapsc.com/library/review-of-medical-embryology/chapter-128-development-of-the-lymphatic-system, https://github.com/obophenotype/uberon/issues/1383] xref: http://linkedlifedata.com/resource/umls/id/C1514922 xref: NCIT:C34285 is_a: UBERON:0034953 ! embryonic lymph sac [Term] id: UBERON:0035079 name: deep intraparotid lymph node namespace: uberon def: "The intraglandular deep parotid lymph nodes are a group of lymph nodes found inside the parotid gland." [http://en.wikipedia.org/wiki/Intraglandular_deep_parotid_lymph_nodes] synonym: "deep intraparotid node" EXACT [] synonym: "intraglandular deep parotid lymph nodes" EXACT [] xref: http://en.wikipedia.org/wiki/Intraglandular_deep_parotid_lymph_nodes xref: http://www.snomedbrowser.com/Codes/Details/75040000 is_a: UBERON:0035080 ! intraparotid lymph node [Term] id: UBERON:0035080 name: intraparotid lymph node namespace: uberon synonym: "intraparotid node" EXACT [] xref: http://www.snomedbrowser.com/Codes/Details/27053001 is_a: UBERON:0015870 ! lymph node of head property_value: IAO:0000116 "requires review. Various subtypes include intraglandular, paraglandular, paraparotid" xsd:string [Term] id: UBERON:0035162 name: infraclavicular lymph node namespace: uberon def: "A lymph node located in the area below the clavicle." [ncithesaurus:Infraclavicular_Lymph_Node] synonym: "deltopectoral lymph node" EXACT [FMA:14193] synonym: "deltopectoral node" EXACT [FMA:14193] synonym: "infraclavicular node" EXACT [FMA:14193] synonym: "nodus lymphaticus infraclavicularis axillae" EXACT [FMA:14193] xref: FMA:14193 xref: http://en.wikipedia.org/wiki/Deltopectoral_lymph_nodes xref: http://linkedlifedata.com/resource/umls/id/C0229743 xref: http://www.snomedbrowser.com/Codes/Details/9659009 xref: NCIT:C63705 is_a: UBERON:0015917 {source="FMA"} ! superficial lymph node [Term] id: UBERON:0035171 name: obturator lymph node namespace: uberon synonym: "obturator node" EXACT [FMA:16656] xref: FMA:16656 xref: http://linkedlifedata.com/resource/umls/id/C0229822 xref: http://www.snomedbrowser.com/Codes/Details/245368003 xref: NCIT:C88141 is_a: UBERON:0015880 {source="FMA"} ! external iliac lymph node [Term] id: UBERON:0035198 name: superficial lymphatic vessel namespace: uberon def: "The tubules that carry lymph throughout the body that are just beneath the surface of the skin." [ncithesaurus:Superficial_Lymphatic_Vessel] synonym: "superficial lymph vessel" EXACT [FMA:52011] xref: FMA:52011 xref: http://linkedlifedata.com/resource/umls/id/C1282745 xref: http://www.snomedbrowser.com/Codes/Details/20315002 xref: NCIT:C33663 is_a: UBERON:0001473 ! lymphatic vessel [Term] id: UBERON:0035204 name: occipital lymph node namespace: uberon def: "A lymph node located in the back of the head adjacent to the trapezius muscle." [ncithesaurus:Occipital_Lymph_Node] synonym: "occipital node" EXACT [FMA:61214] xref: FMA:61214 xref: http://en.wikipedia.org/wiki/Occipital_lymph_nodes xref: http://linkedlifedata.com/resource/umls/id/C0229711 xref: http://www.snomedbrowser.com/Codes/Details/245326003 xref: NCIT:C98188 is_a: UBERON:0015870 ! lymph node of head is_a: UBERON:0015917 {source="FMA"} ! superficial lymph node [Term] id: UBERON:0035219 name: parasternal lymph node namespace: uberon def: "Any of the lymph nodes of the breast located under the ribcage, near the sternum." [ncithesaurus:Internal_Mammary_Lymph_Node] synonym: "internal mammary lymph node" EXACT [FMA:5849] synonym: "nodus parasternale" EXACT [FMA:5849] synonym: "parasternal node" EXACT [FMA:5849] xref: FMA:5849 xref: http://en.wikipedia.org/wiki/Parasternal_lymph_nodes xref: http://linkedlifedata.com/resource/umls/id/C0229755 xref: http://www.snomedbrowser.com/Codes/Details/421997006 xref: NCIT:C32853 is_a: UBERON:0007644 {source="FMA"} ! thoracic lymph node [Term] id: UBERON:0035228 name: tonsillar fossa namespace: uberon def: "Between the plica triangularis and the surface of the palatine tonsils is a space known as the tonsillar fossa (or tonsillar sinus); in many cases, however, this sinus is obliterated by its walls becoming adherent." [http://en.wikipedia.org/wiki/Tonsillar_fossa] synonym: "tonsillar bed" EXACT [FMA:55041] synonym: "tonsillar sinus" EXACT [FMA:55041] xref: FMA:55041 xref: http://linkedlifedata.com/resource/umls/id/C0229881 xref: http://www.snomedbrowser.com/Codes/Details/362596009 xref: NCIT:C12235 xref: Tonsillar:fossa relationship: part_of UBERON:0002372 ! tonsil [Term] id: UBERON:0035279 name: supraclavicular lymph node namespace: uberon def: "A lymph node which is located above the clavicle." [ncithesaurus:Supraclavicular_Lymph_Node] synonym: "nodus lymphaticus supraclavicularis axillae" EXACT LATIN [FMA:14192, FMA:TA] synonym: "supraclavicular node" EXACT [FMA:14192] xref: FMA:14192 xref: http://en.wikipedia.org/wiki/Supraclavicular_lymph_nodes xref: http://linkedlifedata.com/resource/umls/id/C0229730 xref: http://www.snomedbrowser.com/Codes/Details/245325004 xref: NCIT:C12903 is_a: UBERON:0002429 {source="FMA"} ! cervical lymph node [Term] id: UBERON:0035371 name: retroperitoneal lymph node namespace: uberon def: "A lymph node located in the retroperitoneal space." [ncithesaurus:Retroperitoneal_Lymph_Node] synonym: "retroperitoneal node" EXACT [FMA:16694] xref: FMA:16694 xref: http://linkedlifedata.com/resource/umls/id/C0229802 xref: http://www.snomedbrowser.com/Codes/Details/249613000 xref: NCIT:C98189 is_a: UBERON:0000029 ! lymph node [Term] id: UBERON:0035495 name: hilum of lymph node namespace: uberon def: "The concave side of the lymph node." [ncithesaurus:Lymph_Node_Hilum] synonym: "hilum nodi lymphoidei" EXACT LATIN [FMA:62842, FMA:TA] synonym: "lymph node hilum" EXACT [FMA:62842] xref: FMA:62842 xref: http://linkedlifedata.com/resource/umls/id/C0229703 xref: http://www.snomedbrowser.com/Codes/Details/327052008 xref: NCIT:C33031 relationship: part_of UBERON:0000029 ! lymph node [Term] id: UBERON:0035520 name: anterior mediastinal lymph node namespace: uberon def: "A lymph node located in the superior mediastinum that collects lymph from the thymus, the pericardium, and the right side of the heart." [ncithesaurus:Anterior_Mediastinal_Lymph_Node] synonym: "anterior mediastinal node" EXACT [FMA:12775] xref: FMA:12775 xref: http://linkedlifedata.com/resource/umls/id/C0229758 xref: http://www.snomedbrowser.com/Codes/Details/245335005 xref: NCIT:C32097 is_a: UBERON:0002524 {source="FMA"} ! mediastinal lymph node [Term] id: UBERON:0035545 name: deep lymphatic vessel namespace: uberon def: "The tubules that carry lymph throughout the body that are in the interior of the body or limbs." [ncithesaurus:Deep_Lymphatic_Vessel] synonym: "deep lymph vessel" EXACT [FMA:52012] xref: FMA:52012 xref: http://linkedlifedata.com/resource/umls/id/C1282746 xref: http://www.snomedbrowser.com/Codes/Details/14033005 xref: NCIT:C32439 is_a: UBERON:0001473 ! lymphatic vessel [Term] id: UBERON:0035608 name: dura mater lymph vessel namespace: uberon def: "Any lymph vessel that is located in the dura mater of the brain." [https://doi.org/10.1038/nature14432, https://doi.org/10.1111/joa.12381] comment: Louveau et al (DOI:10.1038/nature14432) claim the discovery of lymphatics in the cerebral dura mater, but this is disputed by Bucchieri et al (DOI:10.1111/joa.12381) synonym: "dural lymph vasculature" RELATED [] synonym: "dural lymph vessel" EXACT [] is_a: UBERON:0001473 ! lymphatic vessel property_value: UBPROP:0000010 "while Louveau et al (DOI:10.1038/nature14432) state this is within the CNS (thus overturning dogma about the presence of lymphatics in the CNS), in this ontology the dura" xsd:string [Term] id: UBERON:0035764 name: pulmonary lymph node namespace: uberon synonym: "intrapulmonary lymph node" EXACT [FMA:5968] synonym: "pulmonary node" EXACT [FMA:5968] xref: FMA:5968 is_a: UBERON:0000029 ! lymph node [Term] id: UBERON:0035765 name: subsegmental lymph node namespace: uberon def: "The lymph nodes around the subsegmental bronchi." [ncithesaurus:Subsegmental_Lymph_Node, NCITID__Subsegmental_Lymph_Node] xref: FMA:276861 xref: http://linkedlifedata.com/resource/umls/id/C1515031 xref: NCIT:C28745 is_a: UBERON:0035764 {source="FMA"} ! pulmonary lymph node [Term] id: UBERON:0036256 name: iliac lymph sac namespace: uberon def: "An embryonic lymph sac that forms near the junction of the iliac veins with the posterior cardinal veins." [https://discovery.lifemapsc.com/library/review-of-medical-embryology/chapter-128-development-of-the-lymphatic-system, https://github.com/obophenotype/uberon/issues/1383] xref: NCIT:C34191 is_a: UBERON:0034953 {source="NCIT"} ! embryonic lymph sac [Term] id: UBERON:0036260 name: embryonic cisterna chyli namespace: uberon def: "An embryonic lymph sac that is dorsal to the retroperitoneal lymph sac, at the level of the adrenal glands." [https://discovery.lifemapsc.com/library/review-of-medical-embryology/chapter-128-development-of-the-lymphatic-system, https://github.com/obophenotype/uberon/issues/1383] synonym: "future upper portion of the cisterna chyli" RELATED [] xref: EHDAA2:0000253 is_a: UBERON:0034953 {source="cjm"} ! embryonic lymph sac [Term] id: UBERON:0036274 name: tonsillar pillar namespace: uberon def: "The anterior and posterior borders of the tonsillar fossa. They are composed of muscle tissue." [NCIT:C12236] comment: Consider merge with palatopharyngeus xref: NCIT:C12236 relationship: part_of UBERON:0002372 {source="NCIT"} ! tonsil [Term] id: UBERON:0036301 name: vasculature of spleen namespace: uberon xref: FMA:225251 xref: http://www.snomedbrowser.com/Codes/Details/297287005 relationship: part_of UBERON:0002106 ! spleen [Term] id: UBERON:0037480 name: supramammary lymph node namespace: uberon synonym: "supramammary node" EXACT [FMA:12785] xref: FMA:12785 is_a: UBERON:0007644 {source="FMA"} ! thoracic lymph node [Term] id: UBERON:0037494 name: paracardial gastric lymph node namespace: uberon def: "Gastric lymph node located around the cardia of stomach." [FMA:12803] synonym: "aJCC level 16" EXACT [FMA:12803] synonym: "lymph node ring of cardia of stomach" EXACT [FMA:12803] synonym: "paracardial gastric node" EXACT [FMA:12803] synonym: "paracardial lymph node" EXACT [FMA:12803] xref: FMA:12803 is_a: UBERON:0015863 {source="FMA"} ! gastric lymph node [Term] id: UBERON:0037500 name: subscapular axillary lymph node namespace: uberon def: "An axillary lymph node that is placed along the lower margin of the posterior wall of the axilla in the course of the subscapular artery." [http://en.wikipedia.org/wiki/Subscapular_axillary_lymph_nodes] synonym: "nodus lymphaticus subscapularis axillae" EXACT [FMA:14187] synonym: "posterior axillary node" EXACT [FMA:14187] synonym: "subcapsular node" EXACT [FMA:14187] xref: FMA:14187 is_a: UBERON:0037560 {source="FMA"} ! superficial axillary lymph node [Term] id: UBERON:0037501 name: pectoral axillary lymph node namespace: uberon def: "An axiallary lymph node along the lower border of the Pectoralis minor, in relation with the lateral thoracic artery. Their afferents drain the skin and muscles of the anterior and lateral thoracic walls, and the central and lateral parts of the mamma; their efferents pass partly to the central and partly to the subclavicular groups of axillary glands." [http://en.wikipedia.org/wiki/Pectoral_axillary_lymph_nodes] synonym: "anterior axillary lymph node" EXACT [FMA:14188, http://en.wikipedia.org/wiki/Pectoral_axillary_lymph_nodes] synonym: "nodus lymphaticus pectoralis axillae" EXACT [FMA:14188] synonym: "pectoral lymph node" EXACT [FMA:14188] xref: FMA:14188 is_a: UBERON:0037560 {source="FMA"} ! superficial axillary lymph node [Term] id: UBERON:0037502 name: central axillary lymph node namespace: uberon def: "An axillary lymph node that is imbedded in the adipose tissue near the base of the axilla." [http://en.wikipedia.org/wiki/Central_lymph_nodes] synonym: "central node" EXACT [FMA:14189] synonym: "nodus lymphaticus centralis axillae" EXACT [FMA:14189] xref: FMA:14189 is_a: UBERON:0037560 {source="FMA"} ! superficial axillary lymph node [Term] id: UBERON:0037503 name: apical axillary lymph node namespace: uberon def: "An axillary lymph node that is situated partly posterior to the upper portion of the Pectoralis minor and partly above the upper border of this muscle." [http://en.wikipedia.org/wiki/Apical_lymph_nodes] synonym: "nodus lymphaticus apicalis axillae" EXACT [FMA:14190] xref: FMA:14190 is_a: UBERON:0037560 {source="FMA"} ! superficial axillary lymph node [Term] id: UBERON:0037514 name: intermediate mesenteric lymph node namespace: uberon synonym: "central mesenteric lymph node" EXACT [FMA:16609] synonym: "central superior mesenteric lymph node" EXACT [FMA:16609] synonym: "intermediate lymph node of small intestine" EXACT [FMA:16609] synonym: "intermediate mesenteric node" EXACT [FMA:16609] xref: FMA:16609 is_a: UBERON:0002509 {source="FMA"} ! mesenteric lymph node [Term] id: UBERON:0037515 name: juxta-arterial mesenteric lymph node namespace: uberon synonym: "juxta-arterial mesenteric node" EXACT [FMA:16610] xref: FMA:16610 is_a: UBERON:0002509 {source="FMA"} ! mesenteric lymph node [Term] id: UBERON:0037518 name: epicolic lymph node namespace: uberon synonym: "epicolic node" EXACT [FMA:16613] xref: FMA:16613 is_a: UBERON:0039168 {source="FMA"} ! colic lymph node [Term] id: UBERON:0037521 name: preterminal colic lymph node namespace: uberon synonym: "preterminal colic node" EXACT [FMA:16616] xref: FMA:16616 is_a: UBERON:0039168 {source="FMA"} ! colic lymph node [Term] id: UBERON:0037522 name: ileal lymph node namespace: uberon synonym: "ileal mesentary lymph node" EXACT [FMA:16617] synonym: "ileal node" EXACT [FMA:16617] xref: FMA:16617 is_a: UBERON:0002509 {source="FMA"} ! mesenteric lymph node [Term] id: UBERON:0037527 name: superior pancreaticoduodenal lymph node namespace: uberon synonym: "superior pancreaticoduodenal node" EXACT [FMA:16624] xref: FMA:16624 is_a: UBERON:0016401 {source="FMA"} ! pancreaticoduodenal lymph node [Term] id: UBERON:0037528 name: inferior pancreaticoduodenal lymph node namespace: uberon synonym: "inferior pancreaticoduodenal node" EXACT [FMA:16625] xref: FMA:16625 is_a: UBERON:0016401 {source="FMA"} ! pancreaticoduodenal lymph node [Term] id: UBERON:0037530 name: inferior pancreatic lymph node namespace: uberon def: "Pancreaticosplenioc lymph node located along the inferior margin of pancreas." [FMA:16628] synonym: "inferior pancreatic node" EXACT [FMA:16628] synonym: "inferior pancreatiosplenic lymph node" EXACT [FMA:16628] synonym: "jPS 18 node" EXACT [FMA:16628] synonym: "jPS no. 18 node" EXACT [FMA:16628] synonym: "no. 18 pancreatic lymph node" EXACT [FMA:16628] synonym: "no. 18 pancreaticoduodenal lymph node" EXACT [FMA:16628] xref: FMA:16628 is_a: UBERON:0002527 {source="FMA"} ! pancreatic lymph node [Term] id: UBERON:0037531 name: intestinal lymph node namespace: uberon synonym: "intestinal node" EXACT [FMA:16629] synonym: "visceral lumbar lymph node" EXACT [FMA:16629] xref: FMA:16629 is_a: UBERON:0015860 {source="FMA"} ! visceral abdominal lymph node [Term] id: UBERON:0037532 name: medial common iliac lymph node namespace: uberon synonym: "medial common iliac node" EXACT [FMA:16641] xref: FMA:16641 is_a: UBERON:0015878 {source="FMA"} ! common iliac lymph node [Term] id: UBERON:0037533 name: intermediate common iliac lymph node namespace: uberon synonym: "intermediate common iliac node" EXACT [FMA:16642] xref: FMA:16642 is_a: UBERON:0015878 {source="FMA"} ! common iliac lymph node [Term] id: UBERON:0037534 name: lateral common iliac lymph node namespace: uberon synonym: "lateral common iliac node" EXACT [FMA:16643] xref: FMA:16643 is_a: UBERON:0015878 {source="FMA"} ! common iliac lymph node [Term] id: UBERON:0037535 name: subaortic common iliac lymph node namespace: uberon synonym: "subaortic common iliac node" EXACT [FMA:16644] synonym: "subaortic lymph node" EXACT [FMA:16644] xref: FMA:16644 is_a: UBERON:0015878 {source="FMA"} ! common iliac lymph node [Term] id: UBERON:0037536 name: promontory lymph node namespace: uberon synonym: "promontory node" EXACT [FMA:16645] xref: FMA:16645 is_a: UBERON:0015878 {source="FMA"} ! common iliac lymph node [Term] id: UBERON:0037538 name: medial external iliac lymph node namespace: uberon synonym: "medial external iliac node" EXACT [FMA:16647] xref: FMA:16647 is_a: UBERON:0015880 {source="FMA"} ! external iliac lymph node [Term] id: UBERON:0037539 name: intermediate external iliac lymph node namespace: uberon synonym: "intermediate external iliac node" EXACT [FMA:16648] xref: FMA:16648 is_a: UBERON:0015880 {source="FMA"} ! external iliac lymph node [Term] id: UBERON:0037540 name: lateral external iliac lymph node namespace: uberon synonym: "lateral external iliac node" EXACT [FMA:16649] xref: FMA:16649 is_a: UBERON:0015880 {source="FMA"} ! external iliac lymph node [Term] id: UBERON:0037541 name: interiliac lymph node namespace: uberon synonym: "interiliac node" EXACT [FMA:16651] xref: FMA:16651 is_a: UBERON:0015880 {source="FMA"} ! external iliac lymph node [Term] id: UBERON:0037548 name: superior gluteal lymph node namespace: uberon synonym: "superior gluteal node" EXACT [FMA:16658] xref: FMA:16658 is_a: UBERON:0015883 {source="FMA"} ! gluteal lymph node [Term] id: UBERON:0037549 name: inferior gluteal lymph node namespace: uberon synonym: "inferior gluteal node" EXACT [FMA:16659] xref: FMA:16659 is_a: UBERON:0015883 {source="FMA"} ! gluteal lymph node [Term] id: UBERON:0037559 name: anorectal lymph node namespace: uberon xref: FMA:16669 is_a: UBERON:0015860 {source="FMA"} ! visceral abdominal lymph node [Term] id: UBERON:0037560 name: superficial axillary lymph node namespace: uberon synonym: "axillary node" EXACT [FMA:12771] xref: FMA:12771 is_a: UBERON:0001097 {source="FMA"} ! axillary lymph node [Term] id: UBERON:0037566 name: diaphragmatic lymph node namespace: uberon synonym: "diaphragmatic node" EXACT [FMA:12773] xref: FMA:12773 is_a: UBERON:0002524 {source="FMA"} ! mediastinal lymph node [Term] id: UBERON:0037580 name: left gastric lymph node namespace: uberon def: "Gastric lymph node located along the lesser curvature of stomach." [FMA:12797] synonym: "aJCC level 17L node" EXACT [FMA:12797] synonym: "left gastric node" EXACT [FMA:12797] xref: FMA:12797 is_a: UBERON:0015863 ! gastric lymph node [Term] id: UBERON:0037590 name: lateral axillary lymph node namespace: uberon synonym: "brachial axillary node" EXACT [FMA:14186] synonym: "humeral node" EXACT [FMA:14186] synonym: "nodus lymphaticus brachialis axillae" EXACT [FMA:14186] xref: FMA:14186 is_a: UBERON:0037560 {source="FMA"} ! superficial axillary lymph node [Term] id: UBERON:0037601 name: left parietal lumbar lymph node namespace: uberon synonym: "left parietal lumbar node" EXACT [FMA:16602] xref: FMA:16602 is_a: UBERON:0002526 {source="FMA"} ! lumbar lymph node [Term] id: UBERON:0037614 name: appendicular lymph node namespace: uberon synonym: "appendicular node" EXACT [FMA:16620] xref: FMA:16620 is_a: UBERON:0037531 {source="FMA"} ! intestinal lymph node [Term] id: UBERON:0037615 name: pararectal lymph node namespace: uberon synonym: "pararectal node" EXACT [FMA:16621] synonym: "perirectal lymph node" EXACT [FMA:16621] synonym: "rectal lymph node" EXACT [FMA:16621] xref: FMA:16621 is_a: UBERON:0037531 {source="FMA"} ! intestinal lymph node [Term] id: UBERON:0037722 name: right retropharyngeal lymph node namespace: uberon xref: FMA:224626 is_a: UBERON:0015869 ! retropharyngeal lymph node [Term] id: UBERON:0037723 name: left retropharyngeal lymph node namespace: uberon xref: FMA:224628 is_a: UBERON:0015869 ! retropharyngeal lymph node [Term] id: UBERON:0037763 name: lateral superior deep cervical lymph node namespace: uberon xref: FMA:232351 is_a: UBERON:0012310 {source="FMA"} ! deep lateral cervical lymph node [Term] id: UBERON:0037764 name: anterior superior deep cervical lymph node namespace: uberon xref: FMA:232355 is_a: UBERON:0012310 {source="FMA"} ! deep lateral cervical lymph node [Term] id: UBERON:0037765 name: lateral inferior deep cervical lymph node namespace: uberon xref: FMA:232358 is_a: UBERON:0012310 {source="FMA"} ! deep lateral cervical lymph node [Term] id: UBERON:0037766 name: anterior inferior deep cervical lymph node namespace: uberon xref: FMA:232361 is_a: UBERON:0012310 {source="FMA"} ! deep lateral cervical lymph node [Term] id: UBERON:0037787 name: right occipital lymph node namespace: uberon xref: FMA:232552 is_a: UBERON:0035204 ! occipital lymph node [Term] id: UBERON:0037788 name: left occipital lymph node namespace: uberon xref: FMA:232554 is_a: UBERON:0035204 ! occipital lymph node [Term] id: UBERON:0037789 name: right apical axillary lymph node namespace: uberon xref: FMA:232558 is_a: UBERON:0037503 ! apical axillary lymph node [Term] id: UBERON:0037790 name: left apical axillary lymph node namespace: uberon xref: FMA:232560 is_a: UBERON:0037503 ! apical axillary lymph node [Term] id: UBERON:0037793 name: right subscapular axillary lymph node namespace: uberon xref: FMA:232566 is_a: UBERON:0037500 ! subscapular axillary lymph node [Term] id: UBERON:0037794 name: left subscapular axillary lymph node namespace: uberon xref: FMA:232568 is_a: UBERON:0037500 ! subscapular axillary lymph node [Term] id: UBERON:0037795 name: right pectoral axillary lymph node namespace: uberon xref: FMA:232570 is_a: UBERON:0037501 ! pectoral axillary lymph node [Term] id: UBERON:0037796 name: left pectoral axillary lymph node namespace: uberon xref: FMA:232572 is_a: UBERON:0037501 ! pectoral axillary lymph node [Term] id: UBERON:0037797 name: right central axillary lymph node namespace: uberon xref: FMA:232574 is_a: UBERON:0037502 ! central axillary lymph node [Term] id: UBERON:0037798 name: left central axillary lymph node namespace: uberon xref: FMA:232576 is_a: UBERON:0037502 ! central axillary lymph node [Term] id: UBERON:0037865 name: jugular lymph node namespace: uberon xref: FMA:232854 is_a: UBERON:0002429 {source="FMA"} ! cervical lymph node [Term] id: UBERON:0037995 name: supramandibular lymph node namespace: uberon xref: FMA:234376 is_a: UBERON:0015870 {source="FMA"} ! lymph node of head [Term] id: UBERON:0037998 name: external jugular lymph node namespace: uberon xref: FMA:234382 is_a: UBERON:0002429 {source="FMA"} ! cervical lymph node [Term] id: UBERON:0038001 name: sternal lymph node namespace: uberon xref: FMA:234388 is_a: UBERON:0007644 {source="FMA"} ! thoracic lymph node [Term] id: UBERON:0038002 name: upper intercostal lymph node namespace: uberon xref: FMA:234390 is_a: UBERON:0012236 {source="FMA"} ! intercostal lymph node [Term] id: UBERON:0038003 name: lower intercostal lymph node namespace: uberon xref: FMA:234392 is_a: UBERON:0012236 {source="FMA"} ! intercostal lymph node [Term] id: UBERON:0038037 name: subclavian lymph node namespace: uberon xref: FMA:234498 is_a: UBERON:0002429 {source="FMA"} ! cervical lymph node [Term] id: UBERON:0038048 name: antebrachial lymph node namespace: uberon xref: FMA:234527 is_a: UBERON:0016399 {source="FMA"} ! lymph node of upper limb [Term] id: UBERON:0038053 name: cardiophrenic angle lymph node namespace: uberon synonym: "cardiophrenic angle node" EXACT [FMA:265353] xref: FMA:265353 is_a: UBERON:0015860 {source="FMA"} ! visceral abdominal lymph node [Term] id: UBERON:0038054 name: retrocrural lymph node namespace: uberon synonym: "retrocrural node" EXACT [FMA:265356] xref: FMA:265356 is_a: UBERON:0015860 {source="FMA"} ! visceral abdominal lymph node [Term] id: UBERON:0038093 name: jejunal lymph node namespace: uberon synonym: "jejunal mesentary lymph node" EXACT [FMA:276784] xref: FMA:276784 is_a: UBERON:0002509 {source="FMA"} ! mesenteric lymph node [Term] id: UBERON:0038094 name: inferior rectal lymph node namespace: uberon xref: FMA:276796 is_a: UBERON:0015860 {source="FMA"} ! visceral abdominal lymph node [Term] id: UBERON:0038124 name: medial diaphragmatic lymph node namespace: uberon synonym: "medial diaphragmatic node" EXACT [FMA:12807] synonym: "middle diaphragmatic lymph node" EXACT [FMA:12807] xref: FMA:12807 is_a: UBERON:0037566 {source="FMA"} ! diaphragmatic lymph node [Term] id: UBERON:0038137 name: parietal pre-aortic lymph node namespace: uberon synonym: "parietal pre-aortic node" EXACT [FMA:16603] synonym: "parietal preaortic node" EXACT [FMA:16603] xref: FMA:16603 is_a: UBERON:0037601 {source="FMA"} ! left parietal lumbar lymph node [Term] id: UBERON:0038139 name: retro-aortic lymph node namespace: uberon synonym: "post-aortic lymph node" EXACT [FMA:16607] synonym: "postaortic lymph node" EXACT [FMA:16607] synonym: "retro-aortic node" EXACT [FMA:16607] synonym: "retroaortic lymph node" EXACT [FMA:16607] xref: FMA:16607 is_a: UBERON:0037601 {source="FMA"} ! left parietal lumbar lymph node [Term] id: UBERON:0038587 name: paracardiac lymph node namespace: uberon synonym: "paracardiac node" EXACT [FMA:265350] xref: FMA:265350 is_a: UBERON:0037566 {source="FMA"} ! diaphragmatic lymph node [Term] id: UBERON:0038632 name: pericardial lymph node namespace: uberon xref: FMA:276807 is_a: UBERON:0002524 {source="FMA"} ! mediastinal lymph node [Term] id: UBERON:0038633 name: aortopulmonary lymph node namespace: uberon synonym: "5 thoracic lymph node" EXACT [FMA:276813] synonym: "aortopulmonary window lymph node" EXACT [FMA:276813] synonym: "mediastinal lymph node station # 5" EXACT [FMA:276813] synonym: "station 5 lymph node" EXACT [FMA:276813] synonym: "station 5 N2 lymph node" EXACT [FMA:276813] synonym: "subaortic lymph node" EXACT [FMA:276813] xref: FMA:276813 is_a: UBERON:0002524 {source="FMA"} ! mediastinal lymph node [Term] id: UBERON:0038634 name: para-aortic thoracic lymph node namespace: uberon synonym: "6 thoracic lymph node" EXACT [FMA:276820] synonym: "pre-aortic No. 6 lymph node" EXACT [FMA:276820] synonym: "station 6 lymph node" EXACT [FMA:276820] synonym: "station 6 N2 lymph node" EXACT [FMA:276820] xref: FMA:276820 is_a: UBERON:0002524 {source="FMA"} ! mediastinal lymph node [Term] id: UBERON:0038635 name: interlobar lymph node namespace: uberon synonym: "11 R+L thoracic" EXACT [FMA:276828] synonym: "11 thoracic lymph node" EXACT [FMA:276828] synonym: "station 11 lymph node" EXACT [FMA:276828] synonym: "station 11 N1 lymph node" EXACT [FMA:276828] xref: FMA:276828 is_a: UBERON:0035764 {source="FMA"} ! pulmonary lymph node [Term] id: UBERON:0038638 name: lobar lymph node namespace: uberon synonym: "12R+L thoracic lymph node" EXACT [FMA:276849] synonym: "station 12 lymph node" EXACT [FMA:276849] synonym: "station 12 N1 lymph node" EXACT [FMA:276849] xref: FMA:276849 is_a: UBERON:0035764 {source="FMA"} ! pulmonary lymph node [Term] id: UBERON:0038641 name: segmental lymph node namespace: uberon synonym: "13R+L thoracic lymph node" EXACT [FMA:276855] synonym: "station 13 lymph node" EXACT [FMA:276855] synonym: "station 13 N1 lymph node" EXACT [FMA:276855] xref: FMA:276855 is_a: UBERON:0035764 {source="FMA"} ! pulmonary lymph node [Term] id: UBERON:0038647 name: lymph node of inferior pulmonary ligament namespace: uberon synonym: "9R+L thoracic lymph node" EXACT [FMA:276867] synonym: "inferior pulmonary ligament lymph node" EXACT [FMA:276867] synonym: "node of inferior pulmonary ligament" EXACT [FMA:276867] synonym: "pulmonary ligament lymph node" EXACT [FMA:276867] synonym: "station 9 lymph node" EXACT [FMA:276867] synonym: "station 9 N2 lymph node" EXACT [FMA:276867] xref: FMA:276867 is_a: UBERON:0002524 {source="FMA"} ! mediastinal lymph node [Term] id: UBERON:0038651 name: superior mediastinal lymph node namespace: uberon xref: FMA:276903 is_a: UBERON:0002524 {source="FMA"} ! mediastinal lymph node [Term] id: UBERON:0038684 name: superior left gastric lymph node namespace: uberon def: "Left gastric lymph node located along the left gastric artery." [FMA:277061] synonym: "jPS 7 node" EXACT [FMA:277061] synonym: "jPS no. 7 node" EXACT [FMA:277061] synonym: "no. 7 left gastric lymph node" EXACT [FMA:277061] synonym: "superior left gastric node" EXACT [FMA:277061] xref: FMA:277061 is_a: UBERON:0037580 {source="FMA"} ! left gastric lymph node [Term] id: UBERON:0038685 name: inferior left gastric lymph node namespace: uberon def: "Left gastric lymph node located along the cardiac half of the lesser curvature of stomach in the lesser omentum." [FMA:277064] synonym: "inferior left gastric node" EXACT [FMA:277064] synonym: "jPS 3 node" EXACT [FMA:277064] synonym: "jPS No. 3 node" EXACT [FMA:277064] xref: FMA:277064 is_a: UBERON:0037580 {source="FMA"} ! left gastric lymph node [Term] id: UBERON:0038687 name: visceral lymph node of abdomen namespace: uberon xref: FMA:277227 is_a: UBERON:0002507 ! abdominal lymph node [Term] id: UBERON:0038691 name: common hepatic lymph node namespace: uberon def: "Hepatic lymph node located along the common hepatic artery." [FMA:277259] xref: FMA:277259 is_a: UBERON:0015859 {source="FMA"} ! hepatic lymph node [Term] id: UBERON:0038694 name: hepatoportal lymph node namespace: uberon def: "Hepatic lymph node located along the portal vein." [FMA:277271] synonym: "jPS 12p node" EXACT [FMA:277271] synonym: "jPS No. 12p node" EXACT [FMA:277271] synonym: "no. 12p hepatic lymph node" EXACT [FMA:277271] synonym: "periportal lymph node" EXACT [FMA:277271] synonym: "porta hepatis lymph node" EXACT [FMA:277271] synonym: "portahepatic lymph node" EXACT [FMA:277271] synonym: "portal lymph node" EXACT [FMA:277271] xref: FMA:277271 is_a: UBERON:0015859 {source="FMA"} ! hepatic lymph node [Term] id: UBERON:0038695 name: proximal superior pancreatic lymph node namespace: uberon def: "Superior pancreatic lymph node located along the proximal segment of splenic artery." [FMA:277295] synonym: "jPS 11p node" EXACT [FMA:277295] synonym: "jPS no. 11p node" EXACT [FMA:277295] synonym: "no. 11p superior pancreatic lymph node" EXACT [FMA:277295] synonym: "proximal superior pancreaticosplenic lymph node" EXACT [FMA:277295] xref: FMA:277295 is_a: UBERON:0015865 {source="FMA"} ! pancreaticosplenic lymph node [Term] id: UBERON:0038696 name: distal superior pancreatic lymph node namespace: uberon def: "Superior pancreatic lymph node located along the distal segment of splenic artery." [FMA:277298] synonym: "distal superior pancreaticosplenic lymph node" EXACT [FMA:277298] synonym: "jPS 11d node" EXACT [FMA:277298] synonym: "jPS no. 11d node" EXACT [FMA:277298] synonym: "no. 11d superior pancreatic lymph node" EXACT [FMA:277298] xref: FMA:277298 is_a: UBERON:0015865 {source="FMA"} ! pancreaticosplenic lymph node [Term] id: UBERON:0038697 name: anterior superior pancreaticoduodenal lymph node namespace: uberon def: "Superior pancreaticoduodenal lymph node located on the anterior anterior of superior region of head of pancreas." [FMA:277305] synonym: "anterosuperior pancreaticoduodenal lymph node" EXACT [FMA:277305] synonym: "jPS 17a node" EXACT [FMA:277305] synonym: "jPS no. 17a node" EXACT [FMA:277305] synonym: "no. 17a pancreaticoduodenal lymph node" EXACT [FMA:277305] xref: FMA:277305 is_a: UBERON:0037527 {source="FMA"} ! superior pancreaticoduodenal lymph node [Term] id: UBERON:0038698 name: posterior superior pancreaticoduodenal lymph node namespace: uberon def: "Superior pancreaticoduodenal lymph node located on the posterior aspect of superior portion of head of pancreas." [FMA:277310] synonym: "jPS 13a node" EXACT [FMA:277310] synonym: "jPS no. 13a node" EXACT [FMA:277310] synonym: "no. 13a pancreaticoduodenal lymph node" EXACT [FMA:277310] synonym: "posterosuperior pancreaticoduodenal lymph node" EXACT [FMA:277310] xref: FMA:277310 is_a: UBERON:0037527 {source="FMA"} ! superior pancreaticoduodenal lymph node [Term] id: UBERON:0038699 name: anterior inferior pancreaticoduodenal lymph node namespace: uberon def: "Inferior pancreaticoduodenal lymph node located on the anterior aspect of inferior region of head of pancreas." [FMA:277315] synonym: "anteroinferior pancreaticoduodenal lymph node" EXACT [FMA:277315] synonym: "jPS 17b node" EXACT [FMA:277315] synonym: "jPS no. 17b node" EXACT [FMA:277315] synonym: "no. 17b pancreaticoduodenal lymph node" EXACT [FMA:277315] xref: FMA:277315 is_a: UBERON:0037528 {source="FMA"} ! inferior pancreaticoduodenal lymph node [Term] id: UBERON:0038700 name: posterior inferior pancreaticoduodenal lymph node namespace: uberon def: "Inferior pancreaticoduodenal lymph node located on the posterior aspect of inferior region of head of pancreas." [FMA:277317] synonym: "jPS 13b node" EXACT [FMA:277317] synonym: "jPS no. 13b node" EXACT [FMA:277317] synonym: "no. 13b pancreaticoduodenal lymph node" EXACT [FMA:277317] synonym: "posteroinferior pancreaticoduodenal lymph node" EXACT [FMA:277317] xref: FMA:277317 is_a: UBERON:0037528 {source="FMA"} ! inferior pancreaticoduodenal lymph node [Term] id: UBERON:0038707 name: anterior pancreaticoduodenal lymph node namespace: uberon synonym: "jPS 17 node" EXACT [FMA:277368] synonym: "no. 17 pancreaticoduodenal lymph node" EXACT [FMA:277368] xref: FMA:277368 is_a: UBERON:0016401 {source="FMA"} ! pancreaticoduodenal lymph node [Term] id: UBERON:0038727 name: juxta-intestinal mesenteric lymph node namespace: uberon synonym: "mural mesenteric lymph node" EXACT [FMA:277581] synonym: "para-intestinal mesenteric lymph node" EXACT [FMA:277581] xref: FMA:277581 is_a: UBERON:0002509 {source="FMA"} ! mesenteric lymph node [Term] id: UBERON:0038734 name: visceral pre-aortic lymph node namespace: uberon def: "Intestinal lymph node located anterior to aorta." [FMA:277610] synonym: "visceral para-aortic lymph node" EXACT [FMA:277610] synonym: "visceral pre-aortic node" EXACT [FMA:277610] synonym: "visceral preaortic lymph node" EXACT [FMA:277610] xref: FMA:277610 is_a: UBERON:0037531 {source="FMA"} ! intestinal lymph node [Term] id: UBERON:0038735 name: juxta-arterial jejunal lymph node namespace: uberon xref: FMA:277614 is_a: UBERON:0037515 {source="FMA"} ! juxta-arterial mesenteric lymph node [Term] id: UBERON:0038736 name: juxta-arterial ileal lymph node namespace: uberon xref: FMA:277616 is_a: UBERON:0037515 {source="FMA"} ! juxta-arterial mesenteric lymph node [Term] id: UBERON:0038737 name: intermediate jejunal lymph node namespace: uberon xref: FMA:277618 is_a: UBERON:0037514 {source="FMA"} ! intermediate mesenteric lymph node [Term] id: UBERON:0038738 name: intermediate ileal lymph node namespace: uberon xref: FMA:277620 is_a: UBERON:0037514 {source="FMA"} ! intermediate mesenteric lymph node [Term] id: UBERON:0038746 name: gastro-epiploic lymph node namespace: uberon def: "Gastric lymph node located along the greater curvature of stomach." [FMA:277652] synonym: "gastro-epiploic node" EXACT [FMA:277652] synonym: "gastro-omental lymph node" EXACT [FMA:277652] synonym: "gastro-omental node" EXACT [FMA:277652] synonym: "jPS 4 node" EXACT [FMA:277652] synonym: "jPS No. 4 node" EXACT [FMA:277652] synonym: "lymph node of greater curvature of stomach" EXACT [FMA:277652] xref: FMA:277652 is_a: UBERON:0015863 {source="FMA"} ! gastric lymph node [Term] id: UBERON:0038784 name: pararectal lymph node of pelvis namespace: uberon xref: FMA:278181 is_a: UBERON:0037615 {source="FMA"} ! pararectal lymph node [Term] id: UBERON:0038787 name: superior ileocolic lymph node namespace: uberon xref: FMA:278188 is_a: UBERON:0016378 {source="FMA"} ! ileocolic lymph node [Term] id: UBERON:0038796 name: lymph node along bile duct namespace: uberon synonym: "biliary lymph node" EXACT [FMA:281309] synonym: "jPS 12b node" EXACT [FMA:281309] synonym: "jPS No. 12b node" EXACT [FMA:281309] synonym: "no. 12b hepatic lymph node" EXACT [FMA:281309] xref: FMA:281309 is_a: UBERON:0015859 {source="FMA"} ! hepatic lymph node [Term] id: UBERON:0038818 name: posterior ancreaticoduodenal lymph node namespace: uberon synonym: "jPS 13 node" EXACT [FMA:304577] synonym: "no. 13 pancreaticoduodenal lymph node" EXACT [FMA:304577] xref: FMA:304577 is_a: UBERON:0016401 {source="FMA"} ! pancreaticoduodenal lymph node [Term] id: UBERON:0038849 name: craniocervical lymph node namespace: uberon def: "Lymph node located in either head and neck region." [FMA:321555] synonym: "head and neck lymph node" EXACT [FMA:321555] synonym: "lymph node of head and neck" EXACT [FMA:321555] xref: FMA:321555 is_a: UBERON:0000029 {source="FMA"} ! lymph node [Term] id: UBERON:0038853 name: superficial popliteal lymph node namespace: uberon xref: FMA:44231 is_a: UBERON:0001543 {source="FMA"} ! popliteal lymph node [Term] id: UBERON:0038854 name: deep popliteal lymph node namespace: uberon xref: FMA:44232 is_a: UBERON:0001543 {source="FMA"} ! popliteal lymph node [Term] id: UBERON:0038855 name: superior medial inguinal lymph node namespace: uberon synonym: "superomedial node" EXACT [FMA:44297] xref: FMA:44297 is_a: UBERON:0009007 {source="FMA"} ! superficial inguinal lymph node [Term] id: UBERON:0038856 name: superior lateral inguinal lymph node namespace: uberon synonym: "superolateral node" EXACT [FMA:44301] xref: FMA:44301 is_a: UBERON:0009007 {source="FMA"} ! superficial inguinal lymph node [Term] id: UBERON:0038857 name: inferior inguinal lymph node namespace: uberon synonym: "inferior inguinal node" EXACT [FMA:44302] synonym: "subinguinal lymph node" EXACT [FMA:44302] xref: FMA:44302 is_a: UBERON:0009007 {source="FMA"} ! superficial inguinal lymph node [Term] id: UBERON:0038859 name: intermediate deep inguinal lymph node namespace: uberon synonym: "cloquet's gland" EXACT [FMA:44304] synonym: "cloquet's node" EXACT [FMA:44304] synonym: "intermediate deep inguinal node" EXACT [FMA:44304] synonym: "intermediate inguinal lymph node" EXACT [FMA:44304] synonym: "middle inguinal node" EXACT [FMA:44304] synonym: "nodus inguinales profundi intermedius" EXACT LATIN [FMA:TA] synonym: "nodus lymphoideus inguinales profundi intermedius" EXACT LATIN [FMA:TA] xref: FMA:44304 is_a: UBERON:0009006 {source="FMA"} ! deep inguinal lymph node [Term] id: UBERON:0038860 name: distal deep inguinal lymph node namespace: uberon synonym: "distal deep inguinal node" EXACT [FMA:44305] synonym: "distal inguinal lymph node" EXACT [FMA:44305] synonym: "nodus inguinales profundi distalis" EXACT LATIN [FMA:TA] synonym: "nodus lymphoideus inguinales profundi distalis" EXACT LATIN [FMA:TA] xref: FMA:44305 is_a: UBERON:0009006 {source="FMA"} ! deep inguinal lymph node [Term] id: UBERON:0038861 name: tibial lymph node namespace: uberon synonym: "tIbial node" EXACT [FMA:44306] xref: FMA:44306 is_a: UBERON:0016398 {source="FMA"} ! lymph node of lower limb [Term] id: UBERON:0038864 name: fibular lymph node namespace: uberon synonym: "fibular node" EXACT [FMA:44309] synonym: "nodus fibularis" EXACT LATIN [FMA:TA] synonym: "nodus lymphoideus fibularis" EXACT LATIN [FMA:TA] synonym: "peroneal lymph node" EXACT [FMA:44309] synonym: "peroneal node" EXACT [FMA:44309] xref: FMA:44309 is_a: UBERON:0016398 {source="FMA"} ! lymph node of lower limb [Term] id: UBERON:0038867 name: interpectoral lymph node namespace: uberon synonym: "interpectoral node" EXACT [FMA:44312] xref: FMA:44312 is_a: UBERON:0016399 {source="FMA"} ! lymph node of upper limb [Term] id: UBERON:0038868 name: paramammary lymph node namespace: uberon synonym: "paramammary node" EXACT [FMA:44313] xref: FMA:44313 is_a: UBERON:0007644 {source="FMA"} ! thoracic lymph node [Term] id: UBERON:0038870 name: cubital lymph node namespace: uberon synonym: "cubital node" EXACT [FMA:44315] xref: FMA:44315 is_a: UBERON:0016399 {source="FMA"} ! lymph node of upper limb [Term] id: UBERON:0038871 name: supratrochlear lymph node namespace: uberon synonym: "supra-epicondylar lymph node" EXACT [FMA:44316] synonym: "supratrochlear node" EXACT [FMA:44316] xref: FMA:44316 is_a: UBERON:0016399 {source="FMA"} ! lymph node of upper limb [Term] id: UBERON:0038878 name: lateral diaphragmatic lymph node namespace: uberon synonym: "lateral diaphragmatic node" EXACT [FMA:5935] xref: FMA:5935 is_a: UBERON:0037566 {source="FMA"} ! diaphragmatic lymph node [Term] id: UBERON:0038879 name: anterior diaphragmatic lymph node namespace: uberon synonym: "anterior diaphragmatic node" EXACT [FMA:5936] xref: FMA:5936 is_a: UBERON:0037566 {source="FMA"} ! diaphragmatic lymph node [Term] id: UBERON:0038882 name: posterior diaphragmatic lymph node namespace: uberon synonym: "posterior diaphragmatic node" EXACT [FMA:5941] xref: FMA:5941 is_a: UBERON:0037566 {source="FMA"} ! diaphragmatic lymph node [Term] id: UBERON:0038885 name: brachiocephalic lymph node namespace: uberon synonym: "brachiocephalic node" EXACT [FMA:5944] synonym: "innominate lymph node" EXACT [FMA:5944] xref: FMA:5944 is_a: UBERON:0007644 {source="FMA"} ! thoracic lymph node [Term] id: UBERON:0038888 name: posterior mediastinal lymph node namespace: uberon synonym: "nodus mediastinale posteriore lymphaticus" EXACT [FMA:5947] synonym: "posterior mediastinal node" EXACT [FMA:5947] xref: FMA:5947 is_a: UBERON:0002524 {source="FMA"} ! mediastinal lymph node [Term] id: UBERON:0038894 name: paratracheal lymph node namespace: uberon synonym: "cervical paratracheal lymph node" EXACT [FMA:5953] synonym: "nodus paratracheale lymphaticus" EXACT [FMA:5953] synonym: "paratracheal node" EXACT [FMA:5953] synonym: "tracheal lymph node" EXACT [FMA:5953] xref: FMA:5953 is_a: UBERON:0012311 {source="FMA"} ! deep anterior cervical lymph node [Term] id: UBERON:0038897 name: superior tracheobronchial lymph node namespace: uberon synonym: "4 thoracic lymph node" EXACT [FMA:5959] synonym: "4R+L thoracic lymph node" EXACT [FMA:5959] synonym: "lower paratracheal lymph node" EXACT [FMA:5959] synonym: "nodus tracheobronchiale superiore lymphaticus" EXACT [FMA:5959] synonym: "station 4 lymph node" EXACT [FMA:5959] synonym: "station 4 N2 lymph node" EXACT [FMA:5959] xref: FMA:5959 is_a: UBERON:0015472 {source="FMA"} ! tracheobronchial lymph node [Term] id: UBERON:0038900 name: inferior tracheobronchial lymph node namespace: uberon synonym: "carinate lymph node" EXACT [FMA:5962] synonym: "nodus tracheobronchialis inferioris lymphaticus" EXACT [FMA:5962] xref: FMA:5962 is_a: UBERON:0015472 {source="FMA"} ! tracheobronchial lymph node [Term] id: UBERON:0038920 name: buccinator lymph node namespace: uberon synonym: "buccinator node" EXACT [FMA:61223] synonym: "nodus buccinatorius" EXACT LATIN [FMA:TA] synonym: "nodus lymphoideus buccinatorius" EXACT LATIN [FMA:TA] synonym: "noeuds lymphatiques buccinateurs@fr" EXACT [FMA:61223] xref: FMA:61223 is_a: UBERON:0015871 {source="FMA"} ! facial lymph node [Term] id: UBERON:0038922 name: nasolabial lymph node namespace: uberon synonym: "nasolabial node" EXACT [FMA:61225] synonym: "nodus lymphoideus nasolabialis" EXACT LATIN [FMA:TA] synonym: "nodus nasolabialis" EXACT LATIN [FMA:TA] synonym: "noeud lymphatique naso-labial@fr" EXACT [FMA:61225] xref: FMA:61225 is_a: UBERON:0015871 {source="FMA"} ! facial lymph node [Term] id: UBERON:0038923 name: malar lymph node namespace: uberon synonym: "malar node" EXACT [FMA:61226] synonym: "nodus lymphoideus malaris" EXACT LATIN [FMA:TA] synonym: "nodus malaris" EXACT LATIN [FMA:TA] synonym: "noeud lymphatique malaire@fr" EXACT [FMA:61226] xref: FMA:61226 is_a: UBERON:0015871 {source="FMA"} ! facial lymph node [Term] id: UBERON:0038925 name: lingual lymph node namespace: uberon xref: FMA:61228 is_a: UBERON:0015870 {source="FMA"} ! lymph node of head [Term] id: UBERON:0038929 name: infrahyoid lymph node namespace: uberon synonym: "infrahyoid node" EXACT [FMA:61233] xref: FMA:61233 is_a: UBERON:0012311 {source="FMA"} ! deep anterior cervical lymph node [Term] id: UBERON:0038930 name: prelaryngeal lymph node namespace: uberon synonym: "prelaryngeal node" EXACT [FMA:61234] xref: FMA:61234 is_a: UBERON:0012311 {source="FMA"} ! deep anterior cervical lymph node [Term] id: UBERON:0038931 name: thyroid lymph node namespace: uberon synonym: "thyroid node" EXACT [FMA:61235] xref: FMA:61235 is_a: UBERON:0012311 {source="FMA"} ! deep anterior cervical lymph node [Term] id: UBERON:0038932 name: pretracheal lymph node namespace: uberon synonym: "pretracheal node" EXACT [FMA:61236] xref: FMA:61236 is_a: UBERON:0012311 {source="FMA"} ! deep anterior cervical lymph node [Term] id: UBERON:0038934 name: superior deep lateral cervical lymph node namespace: uberon xref: FMA:61238 is_a: UBERON:0012310 {source="FMA"} ! deep lateral cervical lymph node [Term] id: UBERON:0038935 name: inferior deep lateral cervical lymph node namespace: uberon xref: FMA:61239 is_a: UBERON:0012310 {source="FMA"} ! deep lateral cervical lymph node [Term] id: UBERON:0038936 name: jugulodigastric lymph node namespace: uberon synonym: "jugulodigastric node" EXACT [FMA:61240] synonym: "nodus jugulodigastricus" EXACT LATIN [FMA:TA] synonym: "nodus lymphoideus jugulodigastricus" EXACT LATIN [FMA:TA] synonym: "noeud lymphatique jugulodigastrique@fr" EXACT [FMA:61240] xref: FMA:61240 is_a: UBERON:0012310 {source="FMA"} ! deep lateral cervical lymph node [Term] id: UBERON:0038938 name: accessory cervical lymph node namespace: uberon xref: FMA:61242 is_a: UBERON:0002429 {source="FMA"} ! cervical lymph node [Term] id: UBERON:0038943 name: superior diaphragmatic lymph node namespace: uberon synonym: "superior diaphragmatic node" EXACT [FMA:66167] xref: FMA:66167 is_a: UBERON:0037566 {source="FMA"} ! diaphragmatic lymph node [Term] id: UBERON:0038951 name: suprapyloric lymph node namespace: uberon def: "Pylorioc lymph node located near the bifurcation of gastroduodenal artery and superior to the pylorus." [FMA:66183] synonym: "jPS 5 node" EXACT [FMA:66183] synonym: "jPS no.5 node" EXACT [FMA:66183] synonym: "no. 5 station pyloric lymph node" EXACT [FMA:66183] synonym: "nodus lymphoideus suprapyloricus" EXACT LATIN [FMA:TA] synonym: "nodus suprapyloricus" EXACT LATIN [FMA:TA] synonym: "noeuds lymphatiques supra-pyloriques@fr" EXACT [FMA:66183] synonym: "suprapyloric node" EXACT [FMA:66183] xref: FMA:66183 is_a: UBERON:0015866 {source="FMA"} ! pyloric lymph node [Term] id: UBERON:0038952 name: subpyloric lymph node namespace: uberon def: "Pylorioc lymph node located in the angle between the superior and descending parts of duodenum." [FMA:66184] synonym: "infrapyloric lymph node" EXACT [FMA:66184] synonym: "infrapyloric node" EXACT [FMA:66184] synonym: "jPS 6 node" EXACT [FMA:66184] synonym: "jPS no. 6 node" EXACT [FMA:66184] synonym: "no. 6 station pyloric lymph node" EXACT [FMA:66184] synonym: "subpyloric node" EXACT [FMA:66184] xref: FMA:66184 is_a: UBERON:0015866 {source="FMA"} ! pyloric lymph node [Term] id: UBERON:0038953 name: retropyloric lymph node namespace: uberon synonym: "retropyloric node" EXACT [FMA:66185] xref: FMA:66185 is_a: UBERON:0015866 {source="FMA"} ! pyloric lymph node [Term] id: UBERON:0039162 name: inferior ileocolic lymph node namespace: uberon xref: FMA:78731 is_a: UBERON:0016378 {source="FMA"} ! ileocolic lymph node [Term] id: UBERON:0039163 name: lateral sacral lymph node namespace: uberon xref: FMA:84597 is_a: UBERON:0002528 {source="FMA"} ! sacral lymph node [Term] id: UBERON:0039164 name: medial sacral lymph node namespace: uberon xref: FMA:84598 is_a: UBERON:0002528 {source="FMA"} ! sacral lymph node [Term] id: UBERON:0039167 name: bronchopulmonary lymph node namespace: uberon def: "A tracheobronchial lymph node situated in the hilum of a lung." [https://en.wikipedia.org/w/index.php?title=Tracheobronchial_lymph_nodes&oldid=974745862, https://orcid.org/0000-0002-2825-0621] synonym: "10 R+L thoracic" EXACT [FMA:5965] synonym: "bronchopulmonary node" EXACT [FMA:5965] synonym: "hilar lymph node" EXACT [FMA:5965] synonym: "station 10 lymph node" EXACT [FMA:5965] synonym: "station 10 N1 lymph node" EXACT [FMA:5965] xref: FMA:5965 is_a: UBERON:0007644 {source="https://orcid.org/0000-0002-2825-0621", source="FMA"} ! thoracic lymph node [Term] id: UBERON:0039168 name: colic lymph node namespace: uberon synonym: "colic node" EXACT [FMA:16612] synonym: "pericolic lymph node" EXACT [FMA:16612] synonym: "pericolonic lymph node" EXACT [FMA:16612] xref: FMA:16612 xref: http://www.snomedbrowser.com/Codes/Details/281593008 is_a: UBERON:0037531 {source="FMA"} ! intestinal lymph node [Term] id: UBERON:1000023 name: spleen pulp namespace: uberon def: "The parenchyma of the spleen, consisting of lymphocytes and macrophages. It lies between the splenic trabecula. Red pulp is the part suffused with blood and white pulp consists of areas of lymphatic tissue where there are sleeves of lymphocytes and macrophages." [ncithesaurus:Splenic_Pulp] synonym: "Malpighian corpuscles" EXACT [FMA:15845] synonym: "pulp of spleen" EXACT [] synonym: "splenic pulp" EXACT [] xref: EMAPA:35805 xref: FMA:15845 xref: http://linkedlifedata.com/resource/umls/id/C0229691 xref: http://www.snomedbrowser.com/Codes/Details/13515001 xref: MA:0002487 xref: NCIT:C33603 xref: UMLS:C0229691 {source="ncithesaurus:Splenic_Pulp"} relationship: part_of UBERON:1000024 {source="FMA"} ! parenchyma of spleen [Term] id: UBERON:1000024 name: parenchyma of spleen namespace: uberon def: "A parenchyma that is part of a spleen." [OBOL:automatic] synonym: "splenic parenchyma" EXACT [FMA:16029] xref: FMA:16029 relationship: part_of UBERON:0002106 ! spleen [Term] id: UBERON:2005106 name: longitudinal lateral lymphatic vessel namespace: uberon/phenoscape-anatomy synonym: "LLL" EXACT [TAO:0005106] xref: ZFA:0005106 is_a: UBERON:0004536 ! lymph vasculature property_value: provenance_notes "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" xsd:string created_by: teleost_anatomy_curators [Term] id: UBERON:2005303 name: caudal fin lymph vessel namespace: uberon/phenoscape-anatomy xref: ZFA:0005303 is_a: UBERON:0007384 ! appendage lymph vessel property_value: provenance_notes "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" xsd:string created_by: teleost_anatomy_curators [Term] id: UBERON:2005319 name: intersegmental lymph vessel namespace: uberon/phenoscape-anatomy synonym: "islv" EXACT [TAO:0005319] xref: ZFA:0005319 is_a: UBERON:0004536 ! lymph vasculature property_value: provenance_notes "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" xsd:string created_by: teleost_anatomy_curators [Term] id: UBERON:2005320 name: dorsal longitudinal lymphatic vessel namespace: uberon/phenoscape-anatomy synonym: "dllv" EXACT [TAO:0005320] xref: ZFA:0005320 is_a: UBERON:0004536 ! lymph vasculature property_value: provenance_notes "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" xsd:string created_by: teleost_anatomy_curators [Term] id: http://owltools.org/Q [Typedef] id: part_of name: part of name: part_of namespace: external namespace: protein namespace: quality namespace: uberon def: "a core relation that holds between a part and its whole" [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam xref: BFO:0000050 property_value: IAO:0000111 "is part of" xsd:string property_value: IAO:0000112 "my brain is part of my body (continuant parthood, two material entities)" xsd:string property_value: IAO:0000112 "my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)" xsd:string property_value: IAO:0000112 "this day is part of this year (occurrent parthood)" xsd:string property_value: IAO:0000116 "Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other." xsd:string property_value: IAO:0000116 "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime" xsd:string property_value: IAO:0000116 "Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.)\n\nA continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'." xsd:string property_value: IAO:0000118 "part_of" xsd:string property_value: RO:0001900 RO:0001901 property_value: RO:0040042 BFO:0000002 property_value: RO:0040042 BFO:0000003 property_value: RO:0040042 BFO:0000004 property_value: RO:0040042 BFO:0000017 property_value: RO:0040042 BFO:0000019 property_value: RO:0040042 BFO:0000020 property_value: RO:0040042 BFO:0000031 property_value: seeAlso http://ontologydesignpatterns.org/wiki/Community:Parts_and_Collections property_value: seeAlso http://ontologydesignpatterns.org/wiki/Submissions:PartOf property_value: seeAlso http://www.obofoundry.org/ro/#OBO_REL:part_of xsd:string is_transitive: true