format-version: 1.2
data-version: releases/2026-04-01
subsetdef: 1:STAR ""
subsetdef: 2:STAR ""
subsetdef: 3:STAR ""
subsetdef: added_by_HRA "Classes tagged with this subset property were added on request from HuBMAP to support the HuBMAP Human Reference Atlas (HRA)."
subsetdef: added_for_HCA ""
subsetdef: added_for_HCA "Classes tagged with this subset property were added upon request from the Human Cell Atlas (HCA)."
subsetdef: attribute_slim ""
subsetdef: BDS_subset ""
subsetdef: blood_and_immune_upper_slim ""
subsetdef: cell_quality ""
subsetdef: cellxgene_subset ""
subsetdef: common_anatomy "Terms applicable across life, not restricted to Metazoa"
subsetdef: cumbo "CUMBO"
subsetdef: cyclostome_subset "cyclostome structures"
subsetdef: defined_by_cytoarchitecture "brain region defined by cyto-architecture"
subsetdef: defined_by_ordinal_series "classes that are defined by relative position counting from first in a series of elements along an axis in an individual organism rather than by strict homology"
subsetdef: developmental_classification "developmental_classification"
subsetdef: disposition_slim ""
subsetdef: dubious_grouping "Indicates that subclasses in AOs may be inappropriately linked"
subsetdef: early_development "A class that represents an early developmental structure, like a blastocyst. This part of the ontology is undergoing review to remove inappropriate grouping classes."
subsetdef: efo_slim "EFO slim"
subsetdef: emapa_ehdaa2 "derived from the union of EHDAA2 and EMAPA - still to be checked"
subsetdef: eye_upper_slim ""
subsetdef: feed_aligned "subset of classes that have logical defs text defs and synonyms aligned with FEED"
subsetdef: functional_classification "functional_classification"
subsetdef: general_cell_types_upper_slim ""
subsetdef: gocheck_do_not_annotate ""
subsetdef: gocheck_obsoletion_candidate ""
subsetdef: goslim_agr ""
subsetdef: goslim_candida ""
subsetdef: goslim_chembl ""
subsetdef: goslim_drosophila ""
subsetdef: goslim_euk_cellular_processes_ribbon ""
subsetdef: goslim_flybase_ribbon ""
subsetdef: goslim_generic ""
subsetdef: goslim_metagenomics ""
subsetdef: goslim_mouse ""
subsetdef: goslim_pir ""
subsetdef: goslim_plant ""
subsetdef: goslim_plant_ribbon ""
subsetdef: goslim_pombe ""
subsetdef: goslim_prokaryote ""
subsetdef: goslim_prokaryote_ribbon ""
subsetdef: goslim_synapse ""
subsetdef: goslim_yeast ""
subsetdef: grouping_class "Subset consisting of classes creating for grouping purposes"
subsetdef: homology_grouping "A grouping class that depends on an assumption of homology between subclasses"
subsetdef: hpo_slim ""
subsetdef: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension ""
subsetdef: http://purl.obolibrary.org/obo/valid_for_go_gp2term ""
subsetdef: http://purl.obolibrary.org/obo/valid_for_go_ontology ""
subsetdef: http://purl.obolibrary.org/obo/valid_for_gocam ""
subsetdef: human_reference_atlas ""
subsetdef: human_subset ""
subsetdef: inconsistent_with_fma "classes that have some inconsistency with FMA"
subsetdef: kidney_upper_slim ""
subsetdef: location_grouping ""
subsetdef: major_organ "somewhat fuzzy grouping for analysis purposes, currently composed of something like: liver, heart, skeletal, kidney, bladder, brain, skin, mouth, esophagus, stomach, small intestine, large intestines, trachea nose, lungs, brain, spinal cord, peripheral nerves, kidneys, ureters, bladder, urethra, gonads"
subsetdef: metazoa_core "core classes typically found across metazoa. one purpose is to create a rough set of terms that could be used to start a new metazoan AO. Note this subset is not yet fully fleshed out"
subsetdef: mouse_subset ""
subsetdef: mpath_slim ""
subsetdef: non_informative "abstract class brought in to group ontology classes but not informative"
subsetdef: organ_slim "organs, excluding individual muscles and skeletal elements"
subsetdef: pheno_slim "Phenotype slim"
subsetdef: phenotype_rcn "A subset specifically created for the 2012 Phenotype RCN meeting. Includes some human-specific terms that may eventually be removed when they are adequately represented with part of relationships in FMA"
subsetdef: relational_slim ""
subsetdef: ro-eco ""
subsetdef: RO:0002259 ""
subsetdef: scalar_slim ""
subsetdef: uberon_slim "Uberon slim - subset that excludes obscure terms and deep compositional terms"
subsetdef: ubprop:upper_level ""
subsetdef: unverified_taxonomic_grouping "Indicates that the class encompasses classes from other AOs that have not been verified"
subsetdef: upper_level "abstract upper-level terms not directly useful for analysis"
subsetdef: value_slim ""
subsetdef: vertebrate_core "core classes typically found across vertebrates. one purpose is to create a rough set of terms that could be used to start a new vertebrate AO"
synonymtypedef: blast_name ""
synonymtypedef: BRAIN_NAME_ABV "brain name abbreviations (drosophila)"
synonymtypedef: BRAND:NAME ""
synonymtypedef: COMPARATIVE_PREFERRED "preferred term in the context of comparative anatomy"
synonymtypedef: DEPRECATED "A historic synonym, no longer encouraged"
synonymtypedef: DEVELOPMENTAL "developmental term"
synonymtypedef: equivalent_name ""
synonymtypedef: genbank_common_name ""
synonymtypedef: Gene-based ""
synonymtypedef: HOMOLOGY "a synonym made on the basis of a possibly homologous structure in another species"
synonymtypedef: http://purl.obolibrary.org/obo/chebi/INN ""
synonymtypedef: human ""
synonymtypedef: HUMAN_PREFERRED "preferred term when talking about an instance of this class in Homo sapiens"
synonymtypedef: in_part ""
synonymtypedef: INCONSISTENT "indicates that a synonym is used in an inconsistent or confusing way, typically between species"
synonymtypedef: IUPAC:NAME ""
synonymtypedef: MISSPELLING "a mis-spelling that is in common use and thus recorded"
synonymtypedef: NON_AMNIOTE "synonym that is inappropriate for amniotes"
synonymtypedef: NON_MAMMAL "synonym that is inappropriate for mammals"
synonymtypedef: OMO:0003000 "abbreviation"
synonymtypedef: OMO:0003002 "dubious synonym"
synonymtypedef: OMO:0003003 ""
synonymtypedef: OMO:0003004 "plural form"
synonymtypedef: OMO:0003011 "latin term"
synonymtypedef: PENDING_REVIEW "expert consultation and attribution required"
synonymtypedef: PRO-short-label ""
synonymtypedef: scientific_name ""
synonymtypedef: SENSU "taxonomic disambiguation"
synonymtypedef: syngo_official_label ""
synonymtypedef: synonym ""
synonymtypedef: SYSTEMATIC "a systematic synonym used as the base name for design patterns"
synonymtypedef: systematic_synonym ""
synonymtypedef: vertebrate ""
idspace: dc http://purl.org/dc/elements/1.1/
idspace: doap http://usefulinc.com/ns/doap#
idspace: foaf http://xmlns.com/foaf/0.1/
idspace: oboInOwl http://www.geneontology.org/formats/oboInOwl#
idspace: pav http://purl.org/pav/
idspace: sssom https://w3id.org/sssom/
idspace: swrl http://www.w3.org/2003/11/swrl#
idspace: swrlb http://www.w3.org/2003/11/swrlb#
idspace: terms http://purl.org/dc/terms/
treat-xrefs-as-equivalent: AEO
treat-xrefs-as-equivalent: BILA
treat-xrefs-as-equivalent: BSPO
treat-xrefs-as-equivalent: CARO
treat-xrefs-as-equivalent: GO
treat-xrefs-as-equivalent: OG
treat-xrefs-as-equivalent: VSAO
treat-xrefs-as-is_a: BFO
treat-xrefs-as-is_a: VHOG
remark: Aurelie Comte, Bill Bug, Catherine Leroy, Duncan Davidson and Trish Whetzel are also contributors. However their ORCIDs were not found.
ontology: uberon
property_value: dc-contributor https://github.com/orgs/pato-ontology/teams/pato-community
property_value: dc-contributor https://orcid.org/0000-0001-5889-4463
property_value: dc-contributor https://orcid.org/0000-0001-7433-0086
property_value: dc-contributor https://orcid.org/0000-0001-7476-6306
property_value: dc-contributor https://orcid.org/0000-0001-7920-5321
property_value: dc-contributor https://orcid.org/0000-0001-7958-3701
property_value: dc-contributor https://orcid.org/0000-0001-8682-8754
property_value: dc-contributor https://orcid.org/0000-0001-9107-0714
property_value: dc-contributor https://orcid.org/0000-0001-9990-8331
property_value: dc-contributor https://orcid.org/0000-0002-0819-0473
property_value: dc-contributor https://orcid.org/0000-0002-0956-8634
property_value: dc-contributor https://orcid.org/0000-0002-1112-5832
property_value: dc-contributor https://orcid.org/0000-0002-1572-1316
property_value: dc-contributor https://orcid.org/0000-0002-1604-3078
property_value: dc-contributor https://orcid.org/0000-0002-1615-2899
property_value: dc-contributor https://orcid.org/0000-0002-2061-091X
property_value: dc-contributor https://orcid.org/0000-0002-2244-7917
property_value: dc-contributor https://orcid.org/0000-0002-3437-3329
property_value: dc-contributor https://orcid.org/0000-0002-3467-2636
property_value: dc-contributor https://orcid.org/0000-0002-3734-1859
property_value: dc-contributor https://orcid.org/0000-0002-5111-7263
property_value: dc-contributor https://orcid.org/0000-0002-6490-7723
property_value: dc-contributor https://orcid.org/0000-0002-7073-9172
property_value: dc-contributor https://orcid.org/0000-0002-8406-3871
property_value: dc-contributor https://orcid.org/0000-0002-8455-3213
property_value: dc-contributor https://orcid.org/0000-0002-8688-6599
property_value: dc-contributor https://orcid.org/0000-0002-9415-5104
property_value: dc-contributor https://orcid.org/0000-0002-9818-3030
property_value: dc-contributor https://orcid.org/0000-0002-9900-7880
property_value: dc-contributor https://orcid.org/0000-0003-1980-3228
property_value: dc-contributor https://orcid.org/0000-0003-2105-2283
property_value: dc-contributor https://orcid.org/0000-0003-2338-2550
property_value: dc-contributor https://orcid.org/0000-0003-3691-0324
property_value: dc-contributor https://orcid.org/0000-0003-4423-4370
property_value: dc-contributor https://www.wikidata.org/wiki/Q11695472
property_value: dc-contributor https://www.wikidata.org/wiki/Q23809253
property_value: dc-contributor https://www.wikidata.org/wiki/Q4964264
property_value: dc-contributor https://www.wikidata.org/wiki/Q54985720
property_value: dc-contributor https://www.wikidata.org/wiki/Q6983890
property_value: dc-contributor https://www.wikidata.org/wiki/Q7650732
property_value: dc-contributor https://www.wikidata.org/wiki/Q85793053
property_value: dc-creator https://orcid.org/0000-0001-5839-6798
property_value: dc-creator https://orcid.org/0000-0001-7972-3866
property_value: dc-creator https://orcid.org/0000-0001-9114-8737
property_value: dc-creator https://orcid.org/0000-0002-1810-9886
property_value: dc-creator https://orcid.org/0000-0002-6601-2165
property_value: dc-creator https://orcid.org/0000-0002-7356-1779
property_value: dc-creator https://orcid.org/0000-0002-9611-1279
property_value: dc-creator https://orcid.org/0000-0003-3162-7490
property_value: dc-creator https://orcid.org/0000-0003-3308-6245
property_value: dc-description "Uberon is an integrated cross-species anatomy ontology representing a variety of entities classified according to traditional anatomical criteria such as structure, function and developmental lineage. The ontology includes comprehensive relationships to taxon-specific anatomical ontologies, allowing integration of functional, phenotype and expression data." xsd:string
property_value: dc-publisher "http://uberon.org" xsd:anyURI
property_value: dc-source "aggregates AAO from 13:04:2012" xsd:string
property_value: dc-source "aggregates TAO from 09:08:2012" xsd:string
property_value: dc-source "aggregates VSAO from 16:07:2012" xsd:string
property_value: dc-source http://braininfo.rprc.washington.edu/
property_value: dc-source http://dbpedia.org
property_value: dc-source http://en.wikipedia.org/wiki/
property_value: dc-source http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-GrossAnatomy.owl
property_value: dc-source http://palaeos.com
property_value: dc-source http://pons.incf.org/wiki/Common_Upper_Mammalian_Brain_Ontology_%28Cumbo%29
property_value: dc-source http://purl.obolibrary.org/obo/aao.owl
property_value: dc-source http://purl.obolibrary.org/obo/aba.owl
property_value: dc-source http://purl.obolibrary.org/obo/aeo.owl
property_value: dc-source http://purl.obolibrary.org/obo/bila.owl
property_value: dc-source http://purl.obolibrary.org/obo/bto.owl
property_value: dc-source http://purl.obolibrary.org/obo/caro.owl
property_value: dc-source http://purl.obolibrary.org/obo/cl.owl
property_value: dc-source http://purl.obolibrary.org/obo/ehdaa2.owl
property_value: dc-source http://purl.obolibrary.org/obo/emapa.owl
property_value: dc-source http://purl.obolibrary.org/obo/fbbt.owl
property_value: dc-source http://purl.obolibrary.org/obo/fma.owl
property_value: dc-source http://purl.obolibrary.org/obo/go.owl
property_value: dc-source http://purl.obolibrary.org/obo/hp.owl
property_value: dc-source http://purl.obolibrary.org/obo/ma.owl
property_value: dc-source http://purl.obolibrary.org/obo/mp.owl
property_value: dc-source http://purl.obolibrary.org/obo/tao.owl
property_value: dc-source http://purl.obolibrary.org/obo/vhog.owl
property_value: dc-source http://purl.obolibrary.org/obo/vsao.owl
property_value: dc-source http://purl.obolibrary.org/obo/wbbt.owl
property_value: dc-source http://purl.obolibrary.org/obo/xao.owl
property_value: dc-source http://purl.obolibrary.org/obo/zfa.owl
property_value: dc-source http://uri.neuinfo.org/nif/nifstd
property_value: dc-source "http://wiki.phenotypercn.org/wg/phenotypercn/index.php?title=Neural_Crest_Workshop" xsd:anyURI
property_value: dc-source "http://wiki.phenotypercn.org/wiki/August_2012_Notes" xsd:anyURI
property_value: dc-source http://www.brain-map.org
property_value: dc-source http://www.e-lico.eu/public/kupo/kupo.owl
property_value: dc-source http://www.ebi.ac.uk/efo/efo.owl
property_value: dc-source "https://docs.google.com/document/d/16JZOuH9sh_a8uIXA4cqg0Q1H6MV5yCj3-rhuKsZoV_U/edit" xsd:anyURI
property_value: dc-source "https://docs.google.com/document/d/1cPWBqrl_Qy7XHEWFqtR_PgQX61yRkgGuLaiDpnEXxkE/edit" xsd:anyURI
property_value: dc-source "https://docs.google.com/document/d/1MnUgispgGfNQoezYzWzzGTnkAnI0gzRnJIwdip6MMtw/edit" xsd:anyURI
property_value: dc-source "https://docs.google.com/document/d/1r9kNPpFYGdu0SpJDLyFAVQczBlG0wAZCBMd18gG3Ot8/edit#" xsd:anyURI
property_value: dc-source "https://docs.google.com/spreadsheet/ccc?key=0Aj8NJdyb-leqdDM0R3hTVTRHRExDVjRCSkZEbDc5N1E#gid=0" xsd:anyURI
property_value: dc-source "ISBN:0030229073 Invertebrate Zoology, Barnes" xsd:string
property_value: dc-source "ISBN:0073040584 Vertebrates, Kardong" xsd:string
property_value: dc-source "ISBN:0123813611 Comparative Anatomy and Histology: A Mouse and Human Atlas, Treuting and Dintzis" xsd:string
property_value: dc-source "ISBN:0226313379 Fins into Limbs: Evolution, Development, and Transformation, Hall" xsd:string
property_value: dc-source "ISBN:0443065837 Human embryology, Larsen" xsd:string
property_value: dc-source "ISBN:0471888893 Comparative Vertebrate Neuroanatomy: Evolution and Adaptation by Butler and Hodos" xsd:string
property_value: dc-source "ISBN:0683400088 Stedman's Medical Dictionary" xsd:string
property_value: dc-source "ISBN:1588900649 Color Atlas and Textbook of Human Anatomy: Nervous system and sensory organs By Werner Kahle, Michael Frotscher" xsd:string
property_value: dc-source "ISBN:1588903958 Principles and practice of pediatric neurosurgery By A. Leland Albright, P. David Adelson, Ian F. Pollack" xsd:string
property_value: dc-source "ISBN:1607950324 Craniofacial Embryogenetics & Development, 2nd edition, Sperber" xsd:string
property_value: dc-source "ISBN:978-0-12-369548-2 Principles of Developmental Genetics, Sally A Moody" xsd:string
property_value: dc-source "ISBN:9780120749034 The laboratory rat" xsd:string
property_value: dc-source "ISBN:9780397517251 Surgical anatomy of the hand and upper extremity. By James R. Doyle and Michael J. Botte" xsd:string
property_value: dc-source "ISBN:9780674021839 The Tree of Life - Guillaume Lecointre, Herve Le Guyader" xsd:string
property_value: dc-source "ISBN:9780878932504 Developmental Biology" xsd:string
property_value: dc-source "MESH" xsd:string
property_value: dc-source "PMID:11433360 Placental development: lessons from mouse mutants" xsd:string
property_value: dc-source "PMID:16417468 Forgotten and novel aspects in pancreas development, Pieler and Chen" xsd:string
property_value: dc-title "Uber-anatomy ontology" xsd:string
property_value: dcterms-isReferencedBy "http://genomebiology.com/2012/13/1/R5" xsd:anyURI
property_value: dcterms-isReferencedBy "http://www.ncbi.nlm.nih.gov/pubmed/22293552" xsd:anyURI
property_value: dcterms-license http://creativecommons.org/licenses/by/3.0/
property_value: doap-bug-database "https://github.com/obophenotype/uberon/issues/" xsd:anyURI
property_value: doap-GitRepository "https://github.com/cmungall/uberon/" xsd:anyURI
property_value: doap-mailing-list "https://lists.sourceforge.net/lists/listinfo/obo-anatomy" xsd:anyURI
property_value: doap-SVNRepository "https://obo.svn.sourceforge.net/svnroot/obo/uberon/" xsd:anyURI
property_value: foaf-homepage "http://uberon.org" xsd:anyURI
property_value: has_ontology_root_term UBERON:0000104
property_value: has_ontology_root_term UBERON:0000105
property_value: has_ontology_root_term UBERON:0001062
property_value: has_ontology_root_term UBERON:0035943
treat-xrefs-as-has-subclass: EHDAA
treat-xrefs-as-has-subclass: EV
treat-xrefs-as-has-subclass: NCIT
treat-xrefs-as-has-subclass: OGES
treat-xrefs-as-has-subclass: SCTID
treat-xrefs-as-reverse-genus-differentia: AAO part_of NCBITaxon:8292
treat-xrefs-as-reverse-genus-differentia: DHBA part_of NCBITaxon:9606
treat-xrefs-as-reverse-genus-differentia: EHDAA2 part_of NCBITaxon:9606
treat-xrefs-as-reverse-genus-differentia: EMAPA part_of NCBITaxon:10090
treat-xrefs-as-reverse-genus-differentia: FBdv part_of NCBITaxon:7227
treat-xrefs-as-reverse-genus-differentia: FMA part_of NCBITaxon:9606
treat-xrefs-as-reverse-genus-differentia: HAO part_of NCBITaxon:7399
treat-xrefs-as-reverse-genus-differentia: HBA part_of NCBITaxon:9606
treat-xrefs-as-reverse-genus-differentia: KUPO part_of NCBITaxon:9606
treat-xrefs-as-reverse-genus-differentia: MA part_of NCBITaxon:10090
treat-xrefs-as-reverse-genus-differentia: MFO part_of NCBITaxon:8089
treat-xrefs-as-reverse-genus-differentia: PBA part_of NCBITaxon:9443
treat-xrefs-as-reverse-genus-differentia: SPD part_of NCBITaxon:6893
treat-xrefs-as-reverse-genus-differentia: TADS part_of NCBITaxon:6939
treat-xrefs-as-reverse-genus-differentia: TAO part_of NCBITaxon:32443
treat-xrefs-as-reverse-genus-differentia: TGMA part_of NCBITaxon:44484
treat-xrefs-as-reverse-genus-differentia: WBbt part_of NCBITaxon:6237
treat-xrefs-as-reverse-genus-differentia: WBls part_of NCBITaxon:6237
treat-xrefs-as-reverse-genus-differentia: XAO part_of NCBITaxon:8353
treat-xrefs-as-reverse-genus-differentia: ZFA part_of NCBITaxon:7954
treat-xrefs-as-reverse-genus-differentia: ZFS part_of NCBITaxon:7954
[Term]
id: BFO:0000001
name: entity
property_value: editor_note "BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81" xsd:string
property_value: example_of_usage "Julius Caesar" xsd:string
property_value: example_of_usage "the Second World War" xsd:string
property_value: example_of_usage "Verdi’s Requiem" xsd:string
property_value: example_of_usage "your body mass index" xsd:string
[Term]
id: BFO:0000002
name: continuant
is_a: BFO:0000001 ! entity
disjoint_from: BFO:0000003 ! occurrent
relationship: part_of BFO:0000002 {all_only="true"} ! continuant
property_value: editor_note "BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240" xsd:string
[Term]
id: BFO:0000003
name: occurrent
is_a: BFO:0000001 ! entity
relationship: part_of BFO:0000003 {all_only="true"} ! occurrent
property_value: editor_note "BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region" xsd:string
property_value: editor_note "BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players." xsd:string
property_value: IAO:0000589 "processual entity (BFO)" xsd:string
[Term]
id: BFO:0000004
name: independent continuant
is_a: BFO:0000002 ! continuant
disjoint_from: BFO:0000020 ! specifically dependent continuant
disjoint_from: BFO:0000031 ! generically dependent continuant
relationship: part_of BFO:0000004 {all_only="true"} ! independent continuant
property_value: example_of_usage "a chair" xsd:string
property_value: example_of_usage "a heart" xsd:string
property_value: example_of_usage "a leg" xsd:string
property_value: example_of_usage "a molecule" xsd:string
property_value: example_of_usage "a spatial region" xsd:string
property_value: example_of_usage "an atom" xsd:string
property_value: example_of_usage "an orchestra." xsd:string
property_value: example_of_usage "an organism" xsd:string
property_value: example_of_usage "the bottom right portion of a human torso" xsd:string
property_value: example_of_usage "the interior of your mouth" xsd:string
property_value: IAO:0000589 "anatomical entity (BFO)" xsd:string
[Term]
id: BFO:0000006
name: spatial region
is_a: BFO:0000141 ! immaterial entity
property_value: editor_note "BFO 2 Reference: Spatial regions do not participate in processes." xsd:string
[Term]
id: BFO:0000015
name: process
is_a: BFO:0000003 ! occurrent
property_value: editor_note "BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war)" xsd:string
property_value: example_of_usage "a process of cell-division, \\ a beating of the heart" xsd:string
property_value: example_of_usage "a process of meiosis" xsd:string
property_value: example_of_usage "a process of sleeping" xsd:string
property_value: example_of_usage "the course of a disease" xsd:string
property_value: example_of_usage "the flight of a bird" xsd:string
property_value: example_of_usage "the life of an organism" xsd:string
property_value: example_of_usage "your process of aging." xsd:string
[Term]
id: BFO:0000016
name: disposition
is_a: BFO:0000017 ! realizable entity
disjoint_from: BFO:0000023 ! role
property_value: editor_note "BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type." xsd:string
property_value: example_of_usage "an atom of element X has the disposition to decay to an atom of element Y" xsd:string
property_value: example_of_usage "certain people have a predisposition to colon cancer" xsd:string
property_value: example_of_usage "children are innately disposed to categorize objects in certain ways." xsd:string
property_value: example_of_usage "the cell wall is disposed to filter chemicals in endocytosis and exocytosis" xsd:string
[Term]
id: BFO:0000017
name: realizable entity
is_a: BFO:0000020 ! specifically dependent continuant
is_a: COB:0000502 ! characteristic
disjoint_from: BFO:0000019 ! quality
relationship: part_of BFO:0000017 {all_only="true"} ! realizable entity
property_value: example_of_usage "the disposition of this piece of metal to conduct electricity." xsd:string
property_value: example_of_usage "the disposition of your blood to coagulate" xsd:string
property_value: example_of_usage "the function of your reproductive organs" xsd:string
property_value: example_of_usage "the role of being a doctor" xsd:string
property_value: example_of_usage "the role of this boundary to delineate where Utah and Colorado meet" xsd:string
[Term]
id: BFO:0000019
name: quality
is_a: BFO:0000020 ! specifically dependent continuant
relationship: part_of BFO:0000019 {all_only="true"} ! quality
property_value: example_of_usage "the ambient temperature of this portion of air" xsd:string
property_value: example_of_usage "the color of a tomato" xsd:string
property_value: example_of_usage "the length of the circumference of your waist" xsd:string
property_value: example_of_usage "the mass of this piece of gold." xsd:string
property_value: example_of_usage "the shape of your nose" xsd:string
property_value: example_of_usage "the shape of your nostril" xsd:string
[Term]
id: BFO:0000020
name: specifically dependent continuant
is_a: BFO:0000002 ! continuant
disjoint_from: BFO:0000031 ! generically dependent continuant
relationship: part_of BFO:0000020 {all_only="true"} ! specifically dependent continuant
property_value: example_of_usage "of one-sided specifically dependent continuants: the mass of this tomato" xsd:string
property_value: example_of_usage "of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates." xsd:string
property_value: example_of_usage "Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key" xsd:string
property_value: example_of_usage "the disposition of this fish to decay" xsd:string
property_value: example_of_usage "the function of this heart: to pump blood" xsd:string
property_value: example_of_usage "the mutual dependence of proton donors and acceptors in chemical reactions [79" xsd:string
property_value: example_of_usage "the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction" xsd:string
property_value: example_of_usage "the pink color of a medium rare piece of grilled filet mignon at its center" xsd:string
property_value: example_of_usage "the role of being a doctor" xsd:string
property_value: example_of_usage "the shape of this hole." xsd:string
property_value: example_of_usage "the smell of this portion of mozzarella" xsd:string
[Term]
id: BFO:0000023
name: role
is_a: BFO:0000017 ! realizable entity
property_value: editor_note "BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals – professor, sergeant, nurse – only during certain phases in their lives." xsd:string
property_value: example_of_usage "John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married." xsd:string
property_value: example_of_usage "the priest role" xsd:string
property_value: example_of_usage "the role of a boundary to demarcate two neighboring administrative territories" xsd:string
property_value: example_of_usage "the role of a building in serving as a military target" xsd:string
property_value: example_of_usage "the role of a stone in marking a property boundary" xsd:string
property_value: example_of_usage "the role of subject in a clinical trial" xsd:string
property_value: example_of_usage "the student role" xsd:string
[Term]
id: BFO:0000031
name: generically dependent continuant
is_a: BFO:0000002 ! continuant
relationship: part_of BFO:0000031 {all_only="true"} ! generically dependent continuant
property_value: example_of_usage "The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity." xsd:string
property_value: example_of_usage "the pdf file on your laptop, the pdf file that is a copy thereof on my laptop" xsd:string
property_value: example_of_usage "the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule." xsd:string
[Term]
id: BFO:0000034
name: function
is_a: BFO:0000016 ! disposition
property_value: editor_note "BFO 2 Reference: In the past, we have distinguished two varieties of function, artifactual function and biological function. These are not asserted subtypes of BFO:function however, since the same function – for example: to pump, to transport – can exist both in artifacts and in biological entities. The asserted subtypes of function that would be needed in order to yield a separate monoheirarchy are not artifactual function, biological function, etc., but rather transporting function, pumping function, etc." xsd:string
property_value: example_of_usage "the function of a hammer to drive in nails" xsd:string
property_value: example_of_usage "the function of a heart pacemaker to regulate the beating of a heart through electricity" xsd:string
property_value: example_of_usage "the function of amylase in saliva to break down starch into sugar" xsd:string
[Term]
id: BFO:0000040
name: material entity
is_a: BFO:0000004 ! independent continuant
disjoint_from: BFO:0000141 ! immaterial entity
property_value: editor_note "BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60" xsd:string
property_value: editor_note "BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity." xsd:string
property_value: editor_note "BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here." xsd:string
property_value: editor_note "Elucidation: An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time." xsd:string
property_value: example_of_usage "a flame" xsd:string
property_value: example_of_usage "a forest fire" xsd:string
property_value: example_of_usage "a human being" xsd:string
property_value: example_of_usage "a hurricane" xsd:string
property_value: example_of_usage "a photon" xsd:string
property_value: example_of_usage "a puff of smoke" xsd:string
property_value: example_of_usage "a sea wave" xsd:string
property_value: example_of_usage "a tornado" xsd:string
property_value: example_of_usage "an aggregate of human beings." xsd:string
property_value: example_of_usage "an energy wave" xsd:string
property_value: example_of_usage "an epidemic" xsd:string
property_value: example_of_usage "the undetached arm of a human being" xsd:string
[Term]
id: BFO:0000141
name: immaterial entity
is_a: BFO:0000004 ! independent continuant
property_value: editor_note "BFO 2 Reference: Immaterial entities are divided into two subgroups:boundaries and sites, which bound, or are demarcated in relation, to material entities, and which can thus change location, shape and size and as their material hosts move or change shape or size (for example: your nasal passage; the hold of a ship; the boundary of Wales (which moves with the rotation of the Earth) [38, 7, 10" xsd:string
[Term]
id: BSPO:0000000
name: left side
def: "The side of an organism that is left of the sagittal plane." [BSPO:cjm]
synonym: "left" EXACT []
is_a: BSPO:0000054 ! anatomical side
relationship: left_of BSPO:0000007 ! right side
relationship: starts_axis BSPO:0000017 ! left-right axis
[Term]
id: BSPO:0000007
name: right side
def: "The side of an organism that is right of the sagittal plane." [BSPO:cjm, BSPO:wd]
synonym: "right" EXACT []
is_a: BSPO:0000054 ! anatomical side
relationship: finishes_axis BSPO:0000017 ! left-right axis
[Term]
id: BSPO:0000010
name: anatomical axis
def: "A straight line through space, intersecting an anatomical entity." [BSPO:cjm]
comment: Axis directions are defined in terms of axes.
xref: http://upload.wikimedia.org/wikipedia/commons/3/34/Anatomical_Directions_and_Axes.JPG
is_a: CARO:0000008 ! anatomical line
relationship: passes_through CARO:0000000 ! anatomical entity
[Term]
id: BSPO:0000013
name: anterior-posterior axis
def: "An axis that extends through an organism from head end to opposite end of body or tail." [BSPO:cjm]
comment: In sponges, AP is used to indicate the direction of movement [in larval stage] (as it is in other metazoans that move, e.g., the basal bilaterians). [PM]
synonym: "A-P axis" EXACT []
synonym: "anteroposterior axis" EXACT []
synonym: "AP axis" EXACT []
synonym: "cephalocaudal axis" NARROW [http://en.wikipedia.org/wiki/Anatomical_terms_of_location]
synonym: "craniocaudal axis" NARROW vertebrate []
synonym: "longitudinal axis" RELATED []
synonym: "rostral/caudal" NARROW vertebrate []
synonym: "rostrocaudal axis" NARROW vertebrate []
is_a: BSPO:0000010 ! anatomical axis
intersection_of: BSPO:0000010 ! anatomical axis
intersection_of: orthogonal_to BSPO:0000018 ! transverse plane
relationship: approximately_perpendicular_to BSPO:0000016 ! dorsal-ventral axis
relationship: orthogonal_to BSPO:0000018 ! transverse plane
[Term]
id: BSPO:0000016
name: dorsal-ventral axis
def: "An axis that is approximately perpendicular to the anterior-posterior axis and that extends through the horizontal plane of the body." [BSPO:curators]
synonym: "anterior-posterior axis" NARROW human []
synonym: "D-V axis" EXACT []
synonym: "dorsoventral axis" EXACT []
synonym: "DV axis" EXACT []
is_a: BSPO:0000010 ! anatomical axis
intersection_of: BSPO:0000010 ! anatomical axis
intersection_of: orthogonal_to BSPO:0000019 ! horizontal plane
relationship: orthogonal_to BSPO:0000019 ! horizontal plane
[Term]
id: BSPO:0000017
name: left-right axis
def: "An axis that bisects an organism from left to right sides of body, through a sagittal plane." [BSPO:cjm]
synonym: "dextro-sinister axis" EXACT []
synonym: "L-R axis" EXACT []
synonym: "left to right axis" EXACT []
synonym: "LR axis" EXACT []
synonym: "R-L axis" EXACT []
synonym: "right to left axis" EXACT []
synonym: "right-left axis" EXACT []
synonym: "RL axis" EXACT []
is_a: BSPO:0000010 ! anatomical axis
intersection_of: BSPO:0000010 ! anatomical axis
intersection_of: orthogonal_to BSPO:0000417 ! sagittal plane
relationship: orthogonal_to BSPO:0000417 ! sagittal plane
[Term]
id: BSPO:0000018
name: transverse plane
def: "Anatomical plane that divides body into anterior and posterior parts." [BSPO:mah]
synonym: "axial plane" EXACT []
synonym: "axial section" EXACT []
synonym: "cross-section" RELATED []
synonym: "transverse section" EXACT []
xref: FMA:12247
is_a: BSPO:0000400 ! anatomical plane
[Term]
id: BSPO:0000019
name: horizontal plane
def: "Anatomical plane that divides bilateral body into dorsal and ventral parts." [BSPO:mah]
synonym: "coronal section" RELATED []
synonym: "frontal plane" EXACT []
synonym: "frontal section" RELATED []
synonym: "horizontal anatomical plane" EXACT [FMA:52810]
synonym: "horizontal section" EXACT []
xref: FMA:52810
is_a: BSPO:0000400 ! anatomical plane
[Term]
id: BSPO:0000054
name: anatomical side
def: "An anatomical region bounded by a plane perpendicular to an axis through the middle." [BSPO:cjm]
xref: FBql:00005841
is_a: BSPO:0000070 ! anatomical region
[Term]
id: BSPO:0000070
name: anatomical region
def: "A 3D region in space without well-defined compartmental boundaries; for example, the dorsal region of an ectoderm." [BSPO:cjm]
comment: to be merged into CARO
xref: FBql:00005841
is_a: CARO:0000003 ! anatomical structure
[Term]
id: BSPO:0000400
name: anatomical plane
def: "A flat 2D plane intersecting an anatomical continuant, dividing it into two adjacent portions." [BSPO:cjm]
comment: These anatomical sections are applicable to most bilaterally symmetrical animals, but bipedal animals such as humans have more complex usage of these terms. For example, in post-embryonic humans a coronal plane is vertical and a transverse plane is horizontal, but for embryos and quadrupeds a coronal plane is horizontal and a transverse plane is vertical.
synonym: "anatomical cross-section" EXACT []
synonym: "anatomical section" EXACT []
synonym: "cross-section" RELATED []
synonym: "plane" EXACT []
synonym: "section" EXACT []
xref: FMA:242982
is_a: CARO:0000010 ! anatomical boundary
[Term]
id: BSPO:0000417
name: sagittal plane
def: "Anatomical plane that divides a bilateral body into left and right parts, not necessarily of even size." [BSPO:cjm, BSPO:DOS, BSPO:mah]
synonym: "left/right plane" EXACT []
synonym: "median plane" EXACT []
synonym: "sagittal section" EXACT []
xref: FMA:11361
is_a: BSPO:0000010 ! anatomical axis
is_a: BSPO:0000400 ! anatomical plane
intersection_of: BSPO:0000400 ! anatomical plane
intersection_of: BSPO:0001102 BSPO:0000013 ! parallel to anterior-posterior axis
intersection_of: BSPO:0001102 BSPO:0000016 ! parallel to dorsal-ventral axis
intersection_of: orthogonal_to BSPO:0000017 ! left-right axis
relationship: BSPO:0001102 BSPO:0000013 ! parallel to anterior-posterior axis
relationship: BSPO:0001102 BSPO:0000016 ! parallel to dorsal-ventral axis
relationship: orthogonal_to BSPO:0000017 ! left-right axis
[Term]
id: CARO:0000000
name: anatomical entity
def: "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species." [CARO:MAH]
[Term]
id: CARO:0000003
name: anatomical structure
def: "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome." [CC:DOS]
is_a: CARO:0000006 ! material anatomical entity
[Term]
id: CARO:0000006
name: material anatomical entity
def: "An anatomical entity that has mass." [CC:DOS]
is_a: CARO:0000000 ! anatomical entity
[Term]
id: CARO:0000007
name: immaterial anatomical entity
def: "An anatomical entity that has no mass." [CC:DOS]
is_a: CARO:0000000 ! anatomical entity
[Term]
id: CARO:0000008
name: anatomical line
def: "A one dimensional, immaterial anatomical entity." [CC:DOS]
is_a: CARO:0000007 ! immaterial anatomical entity
[Term]
id: CARO:0000010
name: anatomical boundary
def: "A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures." [CC:DOS]
is_a: CARO:0000007 ! immaterial anatomical entity
[Term]
id: CHEBI:10545
name: electron
def: "Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV." []
subset: 3:STAR
synonym: "beta" RELATED [iupac]
synonym: "beta(-)" RELATED [chebi]
synonym: "beta-particle" RELATED [iupac]
synonym: "e" RELATED [iupac]
synonym: "e(-)" RELATED [uniprot_ft]
synonym: "e-" RELATED [kegg.compound]
synonym: "electron" EXACT IUPAC:NAME [IUPAC]
synonym: "electron" RELATED IUPAC:NAME [chebi, iupac, kegg.compound]
synonym: "Elektron" RELATED [chebi]
synonym: "negatron" RELATED [iupac]
xref: kegg.compound:C05359 {source="kegg.compound"}
xref: pubmed:21614077 {source="pubmed"}
xref: wikipedia.en:Electron {source="wikipedia.en"}
is_a: CHEBI:36338 ! lepton
[Term]
id: CHEBI:131565
name: steroid aldehyde
def: "Any steroid substituted by a formyl group." []
subset: 3:STAR
synonym: "steroid aldehydes" RELATED [chebi]
is_a: CHEBI:17478 ! aldehyde
is_a: CHEBI:35341 ! steroid
[Term]
id: CHEBI:131604
name: Mycoplasma genitalium metabolite
def: "Any bacterial metabolite produced during a metabolic reaction in Mycoplasma genitalium." []
subset: 3:STAR
synonym: "Mycoplasma genitalium metabolites" RELATED [chebi]
is_a: CHEBI:76969 ! bacterial metabolite
[Term]
id: CHEBI:131621
name: C19-steroid
def: "A steroid compound with a structure based on a 19-carbon (androstane) skeleton." []
subset: 3:STAR
synonym: "C19-steroids" RELATED [chebi]
is_a: CHEBI:35341 ! steroid
relationship: RO:0018040 CHEBI:35509 ! has parent hydride androstane
[Term]
id: CHEBI:131927
name: dicarboxylic acids and O-substituted derivatives
def: "A class of carbonyl compound encompassing dicarboxylic acids and any derivatives obtained by substitution of either one or both of the carboxy hydrogens." []
subset: 3:STAR
synonym: "dicarboxylic acids and derivatives" RELATED [chebi]
is_a: CHEBI:36586 ! carbonyl compound
[Term]
id: CHEBI:132153
name: hyaluronate
def: "A carbohydrate acid derivative anion obtained by deprotonation of the carboxy groups of hyaluronic acid; major species at pH 7.3." []
subset: 3:STAR
synonym: "hyaluronan" RELATED [uniprot_ft]
synonym: "hyaluronate polyanion" RELATED [chebi]
is_a: CHEBI:61469 ! polyanionic polymer
is_a: CHEBI:63551 ! carbohydrate acid derivative anion
relationship: RO:0018033 CHEBI:16336 ! is deprotonated form of hyaluronic acid
[Term]
id: CHEBI:133294
name: oxo dicarboxylic acid dianion
def: "A dicarboxylic acid dianion obtained by deprotonation of both carboxy groups of any oxo dicarboxylic acid." []
subset: 3:STAR
synonym: "oxo dicarboxylic acid dianions" RELATED [chebi]
is_a: CHEBI:28965 ! dicarboxylic acid dianion
is_a: CHEBI:35903 ! oxo carboxylic acid anion
relationship: RO:0018033 CHEBI:36145 ! is deprotonated form of oxo dicarboxylic acid
[Term]
id: CHEBI:134179
name: volatile organic compound
def: "Any organic compound having an initial boiling point less than or equal to 250 °C (482 °F) measured at a standard atmospheric pressure of 101.3 kPa." []
subset: 3:STAR
synonym: "VOC" RELATED [chebi]
synonym: "VOCs" RELATED [chebi]
synonym: "volatile organic compounds" RELATED [chebi]
xref: wikipedia.en:Volatile_organic_compound {source="wikipedia.en"}
is_a: CHEBI:72695 ! organic molecule
[Term]
id: CHEBI:136849
name: 3-oxo-Delta(4)-steroid group
def: "An organic group derived from any 3-oxo-Δ4-steroid." []
subset: 3:STAR
synonym: "a 3-oxo-Delta4-steroid group" RELATED [uniprot_ft]
is_a: CHEBI:33247 ! organic group
[Term]
id: CHEBI:136889
name: 5beta steroid
def: "Any steroid that has β-configuration at position 5." []
subset: 3:STAR
synonym: "5beta steroids" RELATED [chebi]
synonym: "5beta-steroid" RELATED [chebi]
synonym: "5beta-steroids" RELATED [chebi]
is_a: CHEBI:35341 ! steroid
[Term]
id: CHEBI:138103
name: inorganic acid
def: "A Brønsted acid derived from one or more inorganic compounds. Inorganic acids (also known as mineral acids) form hydrons and conjugate base ions when dissolved in water." []
subset: 3:STAR
synonym: "inorganic acids" RELATED [chebi]
synonym: "mineral acid" RELATED [chebi]
synonym: "mineral acids" RELATED [chebi]
xref: wikipedia.en:Mineral_acid {source="wikipedia.en"}
is_a: CHEBI:39141 ! Bronsted acid
[Term]
id: CHEBI:138366
name: bile acids
def: "Any member of a group of hydroxy steroids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5β-configuration, while in lower vertebrates, some bile acids, known as allo-bile acids, have 5α-configuration." []
subset: 3:STAR
is_a: CHEBI:25384 ! monocarboxylic acid
is_a: CHEBI:35350 ! hydroxy steroid
is_a: CHEBI:36078 ! cholanoid
[Term]
id: CHEBI:13850
name: apoprotein
def: "An apoprotein is a protein devoid of its characteristic prosthetic group or metal." []
subset: 3:STAR
synonym: "apoprotein" EXACT IUPAC:NAME [IUPAC]
synonym: "apoprotein" RELATED IUPAC:NAME [iupac]
synonym: "apoproteins" RELATED [chebi]
xref: kegg.compound:C16240 {source="kegg.compound"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:38560 ! simple protein
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
[Term]
id: CHEBI:138675
name: gas molecular entity
def: "Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0°C and 100 kPa)." []
subset: 3:STAR
synonym: "gas molecular entities" RELATED [chebi]
synonym: "gaseous molecular entities" RELATED [chebi]
synonym: "gaseous molecular entity" RELATED [chebi]
xref: wikipedia.en:https\://en.wikipedia.org/wiki/Gas {source="wikipedia.en"}
is_a: CHEBI:33579 ! main group molecular entity
[Term]
id: CHEBI:139120
name: carotenoid beta-end derivative
def: "Any carotenoid derivative with an β-end group" []
subset: 2:STAR
synonym: "a carotenoid beta-end derivative" RELATED [uniprot_ft]
xref: metacyc.compound:Carotenoid-beta-end-group {source="metacyc.compound"}
is_a: CHEBI:23044 ! carotenoid
[Term]
id: CHEBI:13941
name: carbamate
subset: 3:STAR
synonym: "Carbamat" RELATED [chebi]
synonym: "carbamate" EXACT IUPAC:NAME [IUPAC]
synonym: "carbamate" RELATED IUPAC:NAME [iupac, uniprot_ft]
synonym: "carbamate ion" RELATED [chemidplus]
synonym: "carbamic acid, ion(1-)" RELATED [chemidplus]
synonym: "Karbamat" RELATED [chebi]
xref: beilstein:3903503 {source="beilstein"}
xref: cas:302-11-4 {source="cas"}
xref: gmelin:239604 {source="gmelin"}
is_a: CHEBI:37022 ! amino-acid anion
relationship: RO:0018033 CHEBI:28616 ! is deprotonated form of carbamic acid
[Term]
id: CHEBI:139588
name: alpha-hydroxy ketone
def: "A ketone containing a hydroxy group on the α-carbon relative to the C=O group." []
subset: 3:STAR
synonym: "alpha-hydroxy ketones" RELATED [chebi]
synonym: "alpha-hydroxy-ketone" RELATED [chebi]
synonym: "alpha-hydroxy-ketones" RELATED [chebi]
synonym: "alpha-hydroxyketone" RELATED [chebi]
synonym: "alpha-hydroxyketones" RELATED [chebi]
xref: pubmed:15326516 {source="pubmed"}
xref: pubmed:19908854 {source="pubmed"}
xref: pubmed:20382022 {source="pubmed"}
xref: pubmed:23295224 {source="pubmed"}
is_a: CHEBI:17087 ! ketone
is_a: CHEBI:33822 ! organic hydroxy compound
[Term]
id: CHEBI:139590
name: primary alpha-hydroxy ketone
def: "An α-hydroxy ketone in which the carbonyl group and the hydroxy group are linked by a -CH2 (methylene) group." []
subset: 3:STAR
synonym: "primary alpha-hydroxy ketones" RELATED [chebi]
synonym: "primary alpha-hydroxy-ketone" RELATED [chebi]
synonym: "primary alpha-hydroxy-ketones" RELATED [chebi]
synonym: "primary alpha-hydroxyketone" RELATED [chebi]
synonym: "primary alpha-hydroxyketones" RELATED [chebi]
is_a: CHEBI:139588 ! alpha-hydroxy ketone
is_a: CHEBI:15734 ! primary alcohol
[Term]
id: CHEBI:140325
name: secondary carboxamide
def: "A carboxamide resulting from the formal condensation of a carboxylic acid with a primary amine; formula RC(=O)NHR1." []
subset: 3:STAR
synonym: "secondary carboxamides" RELATED [chebi]
is_a: CHEBI:37622 ! carboxamide
[Term]
id: CHEBI:140601
name: fatty acid 4:0
def: "Any saturated fatty acid containing 4 carbons." []
subset: 3:STAR
is_a: CHEBI:26666 ! short-chain fatty acid
relationship: RO:0018034 CHEBI:78115 ! is protonated form of fatty acid anion 4:0
[Term]
id: CHEBI:141668
name: L-tyrosinal(1+)
def: "A primary ammonium ion resulting from the protonation of the amino group of L-tyrosinal." []
subset: 3:STAR
synonym: "(2S)-1-(4-hydroxyphenyl)-3-oxopropan-2-aminium" EXACT IUPAC:NAME [IUPAC]
synonym: "(2S)-1-(4-hydroxyphenyl)-3-oxopropan-2-aminium" RELATED IUPAC:NAME [iupac]
synonym: "(2S)-1-(p-hydroxyphenyl)-3-oxopropan-2-aminium" RELATED [chebi]
synonym: "L-tyrosinal" RELATED [uniprot_ft]
xref: metacyc.compound:CPD-21526 {source="metacyc.compound"}
xref: pubmed:23281040 {source="pubmed"}
is_a: CHEBI:65296 ! primary ammonium ion
relationship: RO:0018034 CHEBI:46209 ! is protonated form of L-tyrosinal
[Term]
id: CHEBI:142163
name: 24G7 epitope
def: "An antigenic epitope recognized by an anti-bilirubin monoclonal antibody designated 24G7. A substructure of bilirubin IXα, it is the region containing the oxo group at C-1, the methyl group at C-2, C-(4, 5, 6, 9), and N-21 and -22." []
subset: 3:STAR
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:24433 ! group
relationship: RO:0000087 CHEBI:53000 ! has role epitope
[Term]
id: CHEBI:142355
name: purines D-ribonucleoside
def: "A purine ribonucleoside that is a purine derivative attached to a β-D-ribofuranosyl residue at position 9 via a glycosidic (N-glycosyl) linkage." []
subset: 3:STAR
synonym: "a purine D-ribonucleoside" RELATED [uniprot_ft]
is_a: CHEBI:26399 ! purine ribonucleoside
relationship: RO:0018038 CHEBI:26386 ! has functional parent purine nucleobase
relationship: RO:0018038 CHEBI:47013 ! has functional parent D-ribofuranose
[Term]
id: CHEBI:14321
name: glutamate(1-)
def: "An α-amino-acid anion that is the conjugate base of glutamic acid, having anionic carboxy groups and a cationic amino group" []
subset: 3:STAR
synonym: "2-ammoniopentanedioate" RELATED [iupac]
synonym: "glutamate" RELATED [uniprot_ft]
synonym: "glutamate(1-)" RELATED [jcbn]
synonym: "glutamic acid monoanion" RELATED [jcbn]
synonym: "hydrogen glutamate" EXACT IUPAC:NAME [IUPAC]
synonym: "hydrogen glutamate" RELATED IUPAC:NAME [iupac]
xref: gmelin:327908 {source="gmelin"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:33558 ! alpha-amino-acid anion
relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
relationship: RO:0018033 CHEBI:18237 ! is deprotonated form of glutamic acid
relationship: RO:0018034 CHEBI:29987 ! is protonated form of glutamate(2-)
[Term]
id: CHEBI:15339
name: acceptor
alt_id: CHEBI:13699
alt_id: CHEBI:2377
def: "A molecular entity that can accept an electron, a pair of electrons, an atom or a group from another molecular entity." []
subset: 3:STAR
synonym: "A" RELATED [kegg.compound]
synonym: "accepteur" RELATED [chebi]
synonym: "Acceptor" RELATED [kegg.compound]
synonym: "Akzeptor" RELATED [chebi]
synonym: "Hydrogen-acceptor" RELATED [kegg.compound]
synonym: "Oxidized donor" RELATED [kegg.compound]
xref: kegg.compound:C00028 {source="kegg.compound"}
xref: kegg.compound:C16722 {source="kegg.compound"}
is_a: CHEBI:51086 ! chemical role
[Term]
id: CHEBI:15354
name: choline
alt_id: CHEBI:13985
alt_id: CHEBI:23212
alt_id: CHEBI:3665
alt_id: CHEBI:41524
def: "A choline that is the parent compound of the cholines class, consisting of ethanolamine having three methyl substituents attached to the amino function." []
subset: 3:STAR
synonym: "2-hydroxy-N,N,N-trimethylethanaminium" EXACT IUPAC:NAME [IUPAC]
synonym: "2-hydroxy-N,N,N-trimethylethanaminium" RELATED IUPAC:NAME [iupac]
synonym: "Bilineurine" RELATED [kegg.compound]
synonym: "Choline" RELATED [kegg.compound]
synonym: "choline" RELATED [uniprot_ft]
synonym: "CHOLINE ION" RELATED [pdb-ccd]
synonym: "N,N,N-trimethylethanol-ammonium" RELATED [chebi]
synonym: "N-trimethylethanolamine" RELATED [chebi]
synonym: "trimethylethanolamine" RELATED [chebi]
xref: cas:62-49-7 {source="cas"}
xref: drugbank:DB00122 {source="drugbank"}
xref: drugcentral:3097 {source="drugcentral"}
xref: ecmdb:ECMDB00097 {source="ecmdb"}
xref: gmelin:324597 {source="gmelin"}
xref: hmdb:HMDB0000097 {source="hmdb"}
xref: kegg.compound:C00114 {source="kegg.compound"}
xref: kegg.drug:D07690 {source="kegg.drug"}
xref: knapsack:C00007298 {source="knapsack"}
xref: metacyc.compound:CHOLINE {source="metacyc.compound"}
xref: pdb-ccd:CHT {source="pdb-ccd"}
xref: pubmed:10930630 {source="pubmed"}
xref: pubmed:12826235 {source="pubmed"}
xref: pubmed:12946691 {source="pubmed"}
xref: pubmed:14972364 {source="pubmed"}
xref: pubmed:16210714 {source="pubmed"}
xref: pubmed:17087106 {source="pubmed"}
xref: pubmed:17283071 {source="pubmed"}
xref: pubmed:17344490 {source="pubmed"}
xref: pubmed:18204095 {source="pubmed"}
xref: pubmed:18230680 {source="pubmed"}
xref: pubmed:18786517 {source="pubmed"}
xref: pubmed:18786520 {source="pubmed"}
xref: pubmed:19246089 {source="pubmed"}
xref: pubmed:20038853 {source="pubmed"}
xref: pubmed:20446114 {source="pubmed"}
xref: pubmed:22770225 {source="pubmed"}
xref: pubmed:22961562 {source="pubmed"}
xref: pubmed:23095202 {source="pubmed"}
xref: pubmed:23616508 {source="pubmed"}
xref: pubmed:23637565 {source="pubmed"}
xref: pubmed:23733158 {source="pubmed"}
xref: pubmed:6420466 {source="pubmed"}
xref: pubmed:7590654 {source="pubmed"}
xref: pubmed:9517478 {source="pubmed"}
xref: reaxys:1736748 {source="reaxys"}
xref: wikipedia.en:Choline {source="wikipedia.en"}
xref: ymdb:YMDB00227 {source="ymdb"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:23217 ! cholines
relationship: RO:0000087 CHEBI:25512 ! has role neurotransmitter
relationship: RO:0000087 CHEBI:33284 ! has role nutrient
relationship: RO:0000087 CHEBI:50904 ! has role allergen
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0000087 CHEBI:83056 ! has role Daphnia magna metabolite
[Term]
id: CHEBI:15355
name: acetylcholine
alt_id: CHEBI:12686
alt_id: CHEBI:13715
alt_id: CHEBI:22197
alt_id: CHEBI:2416
alt_id: CHEBI:40559
def: "Actylcholine is an ester of acetic acid and choline, which acts as a neurotransmitter." []
subset: 3:STAR
synonym: "2-acetyloxy-N,N,N-trimethylethanaminium" EXACT IUPAC:NAME [IUPAC]
synonym: "2-acetyloxy-N,N,N-trimethylethanaminium" RELATED IUPAC:NAME [iupac]
synonym: "ACETYLCHOLINE" RELATED [pdb-ccd]
synonym: "Acetylcholine" RELATED [kegg.compound]
synonym: "acetylcholine" RELATED [uniprot_ft]
synonym: "ACh" RELATED [chemidplus]
synonym: "Azetylcholin" RELATED [chebi]
synonym: "choline acetate" RELATED [chemidplus]
synonym: "O-Acetylcholine" RELATED [kegg.compound]
xref: beilstein:1764436 {source="beilstein"}
xref: cas:51-84-3 {source="cas"}
xref: drugbank:DB03128 {source="drugbank"}
xref: drugcentral:65 {source="drugcentral"}
xref: gmelin:326108 {source="gmelin"}
xref: kegg.compound:C01996 {source="kegg.compound"}
xref: lincs.smallmolecule:LSM-5888 {source="lincs.smallmolecule"}
xref: pdb-ccd:ACH {source="pdb-ccd"}
xref: pubmed:14764638 {source="pubmed"}
xref: pubmed:15014918 {source="pubmed"}
xref: pubmed:15231705 {source="pubmed"}
xref: pubmed:15361288 {source="pubmed"}
xref: pubmed:18050502 {source="pubmed"}
xref: pubmed:18407448 {source="pubmed"}
xref: pubmed:19255787 {source="pubmed"}
xref: pubmed:20963497 {source="pubmed"}
xref: pubmed:21130809 {source="pubmed"}
xref: pubmed:21246223 {source="pubmed"}
xref: pubmed:21545631 {source="pubmed"}
xref: pubmed:21601579 {source="pubmed"}
xref: wikipedia.en:Acetylcholine {source="wikipedia.en"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:35287 ! acylcholine
is_a: CHEBI:47622 ! acetate ester
relationship: RO:0000087 CHEBI:24621 ! has role hormone
relationship: RO:0000087 CHEBI:25512 ! has role neurotransmitter
relationship: RO:0000087 CHEBI:35620 ! has role vasodilator agent
relationship: RO:0000087 CHEBI:38325 ! has role muscarinic agonist
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
[Term]
id: CHEBI:15366
name: acetic acid
alt_id: CHEBI:22169
alt_id: CHEBI:2387
alt_id: CHEBI:40486
def: "A simple monocarboxylic acid containing two carbons." []
subset: 3:STAR
synonym: "ACETIC ACID" EXACT [PDBeChem]
synonym: "ACETIC ACID" RELATED [pdb-ccd]
synonym: "Acetic acid" EXACT [KEGG_COMPOUND]
synonym: "Acetic acid" RELATED [kegg.compound]
synonym: "acetic acid" EXACT IUPAC:NAME [IUPAC]
synonym: "acetic acid" RELATED IUPAC:NAME [iupac]
synonym: "acide acetique" RELATED [chemidplus]
synonym: "AcOH" RELATED [chebi]
synonym: "CH3-COOH" RELATED [iupac]
synonym: "CH3CO2H" RELATED [chebi]
synonym: "E 260" RELATED [chebi]
synonym: "E-260" RELATED [chebi]
synonym: "E260" RELATED [chebi]
synonym: "Essigsaeure" RELATED [chebi]
synonym: "Ethanoic acid" RELATED [kegg.compound]
synonym: "ethoic acid" RELATED [chebi]
synonym: "Ethylic acid" RELATED [chemidplus]
synonym: "HOAc" RELATED [chebi]
synonym: "INS No. 260" RELATED [chebi]
synonym: "MeCO2H" RELATED [chebi]
synonym: "MeCOOH" RELATED [chebi]
synonym: "Methanecarboxylic acid" RELATED [chemidplus]
xref: cas:64-19-7 {source="cas"}
xref: drugcentral:4211 {source="drugcentral"}
xref: gmelin:1380 {source="gmelin"}
xref: hmdb:HMDB0000042 {source="hmdb"}
xref: kegg.compound:C00033 {source="kegg.compound"}
xref: kegg.drug:D00010 {source="kegg.drug"}
xref: knapsack:C00001176 {source="knapsack"}
xref: lipidmaps:LMFA01010002 {source="lipidmaps"}
xref: metacyc.compound:ACET {source="metacyc.compound"}
xref: pdb-ccd:ACT {source="pdb-ccd"}
xref: pdb-ccd:ACY {source="pdb-ccd"}
xref: ppdb:1333 {source="ppdb"}
xref: pubmed:12005138 {source="pubmed"}
xref: pubmed:15107950 {source="pubmed"}
xref: pubmed:16630552 {source="pubmed"}
xref: pubmed:16774200 {source="pubmed"}
xref: pubmed:17190852 {source="pubmed"}
xref: pubmed:19416101 {source="pubmed"}
xref: pubmed:19469536 {source="pubmed"}
xref: pubmed:22153255 {source="pubmed"}
xref: pubmed:22173419 {source="pubmed"}
xref: reaxys:506007 {source="reaxys"}
xref: wikipedia.en:Acetic_acid {source="wikipedia.en"}
is_a: CHEBI:25384 ! monocarboxylic acid
relationship: RO:0000087 CHEBI:48356 ! has role protic solvent
relationship: RO:0000087 CHEBI:64049 ! has role food acidity regulator
relationship: RO:0000087 CHEBI:65256 ! has role antimicrobial food preservative
relationship: RO:0000087 CHEBI:83056 ! has role Daphnia magna metabolite
relationship: RO:0018034 CHEBI:30089 ! is protonated form of acetate
[Term]
id: CHEBI:15377
name: water
alt_id: CHEBI:10743
alt_id: CHEBI:13352
alt_id: CHEBI:27313
alt_id: CHEBI:42043
alt_id: CHEBI:42857
alt_id: CHEBI:43228
alt_id: CHEBI:44292
alt_id: CHEBI:44701
alt_id: CHEBI:44819
alt_id: CHEBI:5585
def: "An oxygen hydride consisting of an oxygen atom that is covalently bonded to two hydrogen atoms" []
subset: 3:STAR
synonym: "[OH2]" RELATED [iupac]
synonym: "acqua" RELATED [chebi]
synonym: "agua" RELATED [chebi]
synonym: "aqua" RELATED [chebi]
synonym: "BOUND WATER" RELATED [pdb-ccd]
synonym: "dihydridooxygen" RELATED [iupac]
synonym: "dihydrogen oxide" RELATED [iupac]
synonym: "eau" RELATED [chebi]
synonym: "H(2)O" RELATED [uniprot_ft]
synonym: "H2O" RELATED [kegg.compound]
synonym: "HOH" RELATED [chebi]
synonym: "hydrogen hydroxide" RELATED [chebi]
synonym: "oxidane" EXACT IUPAC:NAME [IUPAC]
synonym: "oxidane" RELATED IUPAC:NAME [iupac]
synonym: "Wasser" RELATED [chebi]
synonym: "WATER" EXACT [PDBeChem]
synonym: "WATER" RELATED [pdb-ccd]
synonym: "Water" EXACT [KEGG_COMPOUND]
synonym: "Water" RELATED [kegg.compound]
synonym: "water" EXACT IUPAC:NAME [IUPAC]
synonym: "water" RELATED IUPAC:NAME [iupac]
xref: cas:7732-18-5 {source="cas"}
xref: gmelin:117 {source="gmelin"}
xref: hmdb:HMDB0002111 {source="hmdb"}
xref: kegg.compound:C00001 {source="kegg.compound"}
xref: kegg.drug:D00001 {source="kegg.drug"}
xref: metacyc.compound:WATER {source="metacyc.compound"}
xref: molbase:1 {source="molbase"}
xref: pdb-ccd:HOH {source="pdb-ccd"}
xref: reaxys:3587155 {source="reaxys"}
xref: wikipedia.en:Water {source="wikipedia.en"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:33693 ! oxygen hydride
is_a: CHEBI:37176 ! mononuclear parent hydride
is_a: CHEBI:52625 ! inorganic hydroxy compound
relationship: RO:0000087 CHEBI:48360 ! has role amphiprotic solvent
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76413 ! has role greenhouse gas
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018033 CHEBI:29412 ! is deprotonated form of oxonium
relationship: RO:0018034 CHEBI:16234 ! is protonated form of hydroxide
[Term]
id: CHEBI:15378
name: hydron
alt_id: CHEBI:10744
alt_id: CHEBI:13357
alt_id: CHEBI:5584
def: "The general name for the hydrogen nucleus, to be used without regard to the hydrogen nuclear mass (either for hydrogen in its natural abundance or where it is not desired to distinguish between the isotopes)." []
subset: 3:STAR
synonym: "H(+)" RELATED [uniprot_ft]
synonym: "H+" RELATED [kegg.compound]
synonym: "hydrogen(1+)" EXACT IUPAC:NAME [IUPAC]
synonym: "hydrogen(1+)" RELATED IUPAC:NAME [iupac]
synonym: "Hydron" RELATED [kegg.compound]
synonym: "hydron" EXACT IUPAC:NAME [IUPAC]
synonym: "hydron" RELATED IUPAC:NAME [iupac]
xref: kegg.compound:C00080 {source="kegg.compound"}
is_a: CHEBI:25414 ! monoatomic monocation
is_a: CHEBI:33251 ! monoatomic hydrogen
is_a: CHEBI:33252 ! atomic nucleus
is_a: CHEBI:60242 ! monovalent inorganic cation
[Term]
id: CHEBI:15379
name: dioxygen
alt_id: CHEBI:10745
alt_id: CHEBI:13416
alt_id: CHEBI:23833
alt_id: CHEBI:25366
alt_id: CHEBI:29097
alt_id: CHEBI:30491
alt_id: CHEBI:44742
alt_id: CHEBI:7860
subset: 3:STAR
synonym: "[OO]" RELATED [molbase]
synonym: "dioxygen" EXACT IUPAC:NAME [IUPAC]
synonym: "dioxygen" RELATED IUPAC:NAME [iupac]
synonym: "dioxygene" RELATED [chebi]
synonym: "Disauerstoff" RELATED [chebi]
synonym: "E 948" RELATED [chebi]
synonym: "E-948" RELATED [chebi]
synonym: "E948" RELATED [chebi]
synonym: "molecular oxygen" RELATED [chebi]
synonym: "O(2)" RELATED [uniprot_ft]
synonym: "O2" RELATED [iupac, kegg.compound]
synonym: "Oxygen" EXACT [KEGG_COMPOUND]
synonym: "Oxygen" RELATED [kegg.compound]
synonym: "OXYGEN MOLECULE" RELATED [pdb-ccd]
xref: cas:7782-44-7 {source="cas"}
xref: gmelin:485 {source="gmelin"}
xref: hmdb:HMDB0001377 {source="hmdb"}
xref: kegg.compound:C00007 {source="kegg.compound"}
xref: kegg.drug:D00003 {source="kegg.drug"}
xref: metacyc.compound:OXYGEN-MOLECULE {source="metacyc.compound"}
xref: molbase:750 {source="molbase"}
xref: pdb-ccd:OXY {source="pdb-ccd"}
xref: pubmed:10906528 {source="pubmed"}
xref: pubmed:16977326 {source="pubmed"}
xref: pubmed:18210929 {source="pubmed"}
xref: pubmed:18638417 {source="pubmed"}
xref: pubmed:19840863 {source="pubmed"}
xref: pubmed:7710549 {source="pubmed"}
xref: pubmed:9463773 {source="pubmed"}
xref: wikipedia.en:Oxygen {source="wikipedia.en"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:138675 ! gas molecular entity
is_a: CHEBI:25362 ! elemental molecule
is_a: CHEBI:33263 ! diatomic oxygen
relationship: RO:0000087 CHEBI:27027 ! has role micronutrient
relationship: RO:0000087 CHEBI:33284 ! has role nutrient
relationship: RO:0000087 CHEBI:33893 ! has role reagent
relationship: RO:0000087 CHEBI:35472 ! has role anti-inflammatory drug
relationship: RO:0000087 CHEBI:63248 ! has role oxidising agent
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0000087 CHEBI:77974 ! has role food packaging gas
relationship: RO:0018033 CHEBI:29793 ! is deprotonated form of hydridodioxygen(1+)
[Term]
id: CHEBI:15422
name: ATP
alt_id: CHEBI:10789
alt_id: CHEBI:10841
alt_id: CHEBI:13236
alt_id: CHEBI:22249
alt_id: CHEBI:2359
alt_id: CHEBI:40938
def: "An adenosine 5'-phosphate in which the 5'-phosphate is a triphosphate group. It is involved in the transportation of chemical energy during metabolic pathways." []
subset: 3:STAR
synonym: "adenosine 5'-(tetrahydrogen triphosphate)" EXACT IUPAC:NAME [IUPAC]
synonym: "adenosine 5'-(tetrahydrogen triphosphate)" RELATED IUPAC:NAME [iupac]
synonym: "Adenosine 5'-triphosphate" RELATED [kegg.compound]
synonym: "Adenosine triphosphate" RELATED [chemidplus]
synonym: "ADENOSINE-5'-TRIPHOSPHATE" RELATED [pdb-ccd]
synonym: "ATP" RELATED [kegg.compound]
synonym: "H4atp" RELATED [iupac]
xref: cas:56-65-5 {source="cas"}
xref: drugbank:DB00171 {source="drugbank"}
xref: drugcentral:91 {source="drugcentral"}
xref: gmelin:34857 {source="gmelin"}
xref: hmdb:HMDB0000538 {source="hmdb"}
xref: kegg.compound:C00002 {source="kegg.compound"}
xref: kegg.drug:D08646 {source="kegg.drug"}
xref: knapsack:C00001491 {source="knapsack"}
xref: patent:US3079379 {source="patent"}
xref: pdb-ccd:ATP {source="pdb-ccd"}
xref: reaxys:73010 {source="reaxys"}
xref: wikipedia.en:Adenosine_triphosphate {source="wikipedia.en"}
is_a: CHEBI:37045 ! purine ribonucleoside 5'-triphosphate
is_a: CHEBI:37096 ! adenosine 5'-phosphate
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
relationship: RO:0000087 CHEBI:27027 ! has role micronutrient
relationship: RO:0000087 CHEBI:50733 ! has role nutraceutical
relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
relationship: RO:0018034 CHEBI:57299 ! is protonated form of ATP(3-)
[Term]
id: CHEBI:15440
name: squalene
alt_id: CHEBI:10795
alt_id: CHEBI:10843
alt_id: CHEBI:15104
alt_id: CHEBI:26746
alt_id: CHEBI:9245
def: "A triterpene consisting of 2,6,10,15,19,23-hexamethyltetracosane having six double bonds at the 2-, 6-, 10-, 14-, 18- and 22-positions with (all-E)-configuration." []
subset: 3:STAR
synonym: "(6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene" EXACT IUPAC:NAME [IUPAC]
synonym: "(6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene" RELATED IUPAC:NAME [iupac]
synonym: "(all-E)-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene" RELATED [nist]
synonym: "Spinacene" RELATED [kegg.compound]
synonym: "Squalene" RELATED [kegg.compound]
synonym: "squalene" RELATED [uniprot_ft]
synonym: "Supraene" RELATED [kegg.compound]
xref: beilstein:1728920 {source="beilstein"}
xref: cas:111-02-4 {source="cas"}
xref: hmdb:HMDB0000256 {source="hmdb"}
xref: kegg.compound:C00751 {source="kegg.compound"}
xref: knapsack:C00003755 {source="knapsack"}
xref: lipidmaps:LMPR0106010002 {source="lipidmaps"}
xref: metacyc.compound:SQUALENE {source="metacyc.compound"}
xref: pdb-ccd:SQL {source="pdb-ccd"}
xref: pubmed:16341241 {source="pubmed"}
xref: pubmed:23625688 {source="pubmed"}
xref: pubmed:24362891 {source="pubmed"}
xref: pubmed:25286851 {source="pubmed"}
xref: pubmed:25286853 {source="pubmed"}
xref: pubmed:25987292 {source="pubmed"}
xref: wikipedia.en:Squalene {source="wikipedia.en"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:35191 ! triterpene
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
[Term]
id: CHEBI:15693
name: aldose
alt_id: CHEBI:13755
alt_id: CHEBI:22305
alt_id: CHEBI:2561
def: "Aldehydic parent sugars (polyhydroxy aldehydes H[CH(OH)]nC(=O)H, n ≥ 2) and their intramolecular hemiacetals." []
subset: 3:STAR
synonym: "Aldose" RELATED [kegg.compound]
synonym: "aldoses" RELATED [chebi]
synonym: "an aldose" RELATED [uniprot_ft]
xref: kegg.compound:C01370 {source="kegg.compound"}
xref: wikipedia.en:Aldose {source="wikipedia.en"}
is_a: CHEBI:35381 ! monosaccharide
[Term]
id: CHEBI:15705
name: L-alpha-amino acid
alt_id: CHEBI:13072
alt_id: CHEBI:13243
alt_id: CHEBI:13797
alt_id: CHEBI:21224
alt_id: CHEBI:6175
def: "Any α-amino acid having L-configuration at the α-carbon." []
subset: 3:STAR
synonym: "L-2-Amino acid" RELATED [kegg.compound]
synonym: "L-alpha-amino acid" RELATED [iupac]
synonym: "L-alpha-amino acids" EXACT IUPAC:NAME [IUPAC]
synonym: "L-alpha-amino acids" RELATED IUPAC:NAME [chebi, iupac]
synonym: "L-Amino acid" RELATED [kegg.compound]
xref: kegg.compound:C00151 {source="kegg.compound"}
is_a: CHEBI:33704 ! alpha-amino acid
relationship: RO:0018034 CHEBI:59814 ! is protonated form of L-alpha-amino acid anion
relationship: RO:0018036 CHEBI:59869 ! is tautomer of L-alpha-amino acid zwitterion
[Term]
id: CHEBI:15734
name: primary alcohol
alt_id: CHEBI:13676
alt_id: CHEBI:14887
alt_id: CHEBI:26262
alt_id: CHEBI:57489
alt_id: CHEBI:8406
def: "A primary alcohol is a compound in which a hydroxy group, ‒OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." []
subset: 3:STAR
synonym: "1-Alcohol" RELATED [kegg.compound]
synonym: "a primary alcohol" RELATED [uniprot_ft]
synonym: "Primary alcohol" RELATED [kegg.compound]
synonym: "primary alcohols" RELATED [chebi]
xref: kegg.compound:C00226 {source="kegg.compound"}
is_a: CHEBI:30879 ! alcohol
[Term]
id: CHEBI:15740
name: formate
alt_id: CHEBI:14276
alt_id: CHEBI:24081
def: "A monocarboxylic acid anion that is the conjugate base of formic acid. Induces severe metabolic acidosis and ocular injury in human subjects." []
subset: 3:STAR
synonym: "aminate" RELATED [chebi]
synonym: "formate" EXACT IUPAC:NAME [IUPAC]
synonym: "formate" RELATED IUPAC:NAME [iupac, uniprot_ft]
synonym: "formiate" RELATED [chebi]
synonym: "formic acid, ion(1-)" RELATED [chemidplus]
synonym: "formylate" RELATED [chebi]
synonym: "HCO2 anion" RELATED [nist]
synonym: "hydrogen carboxylate" RELATED [chebi]
synonym: "methanoate" RELATED [chebi]
xref: cas:71-47-6 {source="cas"}
xref: gmelin:1006 {source="gmelin"}
xref: hmdb:HMDB0000142 {source="hmdb"}
xref: kegg.compound:C00058 {source="kegg.compound"}
xref: metacyc.compound:FORMATE {source="metacyc.compound"}
xref: pubmed:17190852 {source="pubmed"}
xref: pubmed:3946945 {source="pubmed"}
xref: reaxys:1901205 {source="reaxys"}
xref: umbbd.compound:c0106 {source="umbbd.compound"}
xref: wikipedia.en:Formate {source="wikipedia.en"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:35757 ! monocarboxylic acid anion
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018033 CHEBI:30751 ! is deprotonated form of formic acid
[Term]
id: CHEBI:15841
name: polypeptide
alt_id: CHEBI:14860
alt_id: CHEBI:8314
def: "A peptide containing ten or more amino acid residues." []
subset: 3:STAR
synonym: "polipeptido" RELATED [chebi]
synonym: "Polypeptid" RELATED [chebi]
synonym: "Polypeptide" RELATED [kegg.compound]
synonym: "polypeptides" EXACT IUPAC:NAME [IUPAC]
synonym: "polypeptides" RELATED IUPAC:NAME [iupac]
xref: kegg.compound:C00403 {source="kegg.compound"}
is_a: CHEBI:16670 ! peptide
is_a: CHEBI:33839 ! macromolecule
[Term]
id: CHEBI:15966
name: D-glutamic acid
alt_id: CHEBI:21023
alt_id: CHEBI:4183
def: "An optically active form of glutamic acid having D-configuration." []
subset: 3:STAR
synonym: "(2R)-2-aminopentanedioic acid" EXACT IUPAC:NAME [IUPAC]
synonym: "(2R)-2-aminopentanedioic acid" RELATED IUPAC:NAME [iupac]
synonym: "(R)-2-aminopentanedioic acid" RELATED [chebi]
synonym: "D-2-Aminoglutaric acid" RELATED [kegg.compound]
synonym: "D-Glutamic acid" EXACT [KEGG_COMPOUND]
synonym: "D-Glutamic acid" RELATED [kegg.compound]
synonym: "D-glutamic acid" EXACT IUPAC:NAME [IUPAC]
synonym: "D-glutamic acid" RELATED IUPAC:NAME [iupac]
synonym: "D-Glutaminic acid" RELATED [kegg.compound]
synonym: "D-Glutaminsaeure" RELATED [chebi]
synonym: "DGL" RELATED [pdb-ccd]
synonym: "glutamic acid D-form" RELATED [chemidplus]
xref: cas:6893-26-1 {source="cas"}
xref: drugbank:DB02517 {source="drugbank"}
xref: gmelin:201189 {source="gmelin"}
xref: hmdb:HMDB0003339 {source="hmdb"}
xref: kegg.compound:C00217 {source="kegg.compound"}
xref: knapsack:C00019577 {source="knapsack"}
xref: metacyc.compound:D-GLT {source="metacyc.compound"}
xref: pdb-ccd:DGL {source="pdb-ccd"}
xref: reaxys:1723800 {source="reaxys"}
is_a: CHEBI:16733 ! D-alpha-amino acid
is_a: CHEBI:18237 ! glutamic acid
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0018034 CHEBI:29986 ! is protonated form of D-glutamate(1-)
relationship: RO:0018039 CHEBI:16015 ! is enantiomer of L-glutamic acid
[Term]
id: CHEBI:15986
name: polynucleotide
alt_id: CHEBI:13672
alt_id: CHEBI:14859
alt_id: CHEBI:8312
def: "A nucleobase-containing molecular entity with a polymeric structure comprised of a linear sequence of 13 or more nucleotide residues." []
subset: 3:STAR
synonym: "Polynucleotide" RELATED [kegg.compound]
synonym: "polynucleotides" RELATED [chebi]
xref: kegg.compound:C00419 {source="kegg.compound"}
is_a: CHEBI:33695 ! information biomacromolecule
is_a: CHEBI:61120 ! nucleobase-containing molecular entity
relationship: has_part CHEBI:50319 ! nucleotide residue
[Term]
id: CHEBI:16015
name: L-glutamic acid
alt_id: CHEBI:21304
alt_id: CHEBI:42825
alt_id: CHEBI:6224
def: "An optically active form of glutamic acid having L-configuration." []
subset: 3:STAR
synonym: "(2S)-2-aminopentanedioic acid" EXACT IUPAC:NAME [IUPAC]
synonym: "(2S)-2-aminopentanedioic acid" RELATED IUPAC:NAME [iupac]
synonym: "(S)-2-aminopentanedioic acid" RELATED [chebi]
synonym: "(S)-glutamic acid" RELATED [nist]
synonym: "acide glutamique" RELATED http://purl.obolibrary.org/obo/chebi/INN [chebi]
synonym: "acido glutamico" RELATED http://purl.obolibrary.org/obo/chebi/INN [chebi]
synonym: "acidum glutamicum" RELATED http://purl.obolibrary.org/obo/chebi/INN [chebi]
synonym: "E" RELATED [chebi]
synonym: "Glu" RELATED [chebi]
synonym: "Glutamate" RELATED [kegg.compound]
synonym: "GLUTAMIC ACID" EXACT [PDBeChem]
synonym: "GLUTAMIC ACID" RELATED [pdb-ccd]
synonym: "glutamic acid" RELATED http://purl.obolibrary.org/obo/chebi/INN [chebi]
synonym: "L-Glu" RELATED [chebi]
synonym: "L-Glutamic acid" EXACT [KEGG_COMPOUND]
synonym: "L-Glutamic acid" RELATED [kegg.compound]
synonym: "L-glutamic acid" EXACT IUPAC:NAME [IUPAC]
synonym: "L-glutamic acid" RELATED IUPAC:NAME [iupac]
synonym: "L-Glutaminic acid" RELATED [kegg.compound]
synonym: "L-Glutaminsaeure" RELATED [chebi]
xref: bpdb:2297 {source="bpdb"}
xref: cas:56-86-0 {source="cas"}
xref: drugbank:DB00142 {source="drugbank"}
xref: drugcentral:1310 {source="drugcentral"}
xref: gmelin:3502 {source="gmelin"}
xref: hmdb:HMDB0000148 {source="hmdb"}
xref: kegg.compound:C00025 {source="kegg.compound"}
xref: kegg.drug:D00007 {source="kegg.drug"}
xref: knapsack:C00001358 {source="knapsack"}
xref: lincs.smallmolecule:LSM-36375 {source="lincs.smallmolecule"}
xref: metacyc.compound:GLT {source="metacyc.compound"}
xref: pdb-ccd:GLU_LFOH {source="pdb-ccd"}
xref: pubmed:15739367 {source="pubmed"}
xref: pubmed:15930465 {source="pubmed"}
xref: pubmed:16719819 {source="pubmed"}
xref: pubmed:16892196 {source="pubmed"}
xref: pubmed:19581495 {source="pubmed"}
xref: pubmed:22219301 {source="pubmed"}
xref: pubmed:22735334 {source="pubmed"}
xref: reaxys:1723801 {source="reaxys"}
xref: wikipedia.en:L-Glutamic_Acid {source="wikipedia.en"}
is_a: CHEBI:18237 ! glutamic acid
is_a: CHEBI:24318 ! glutamine family amino acid
relationship: RO:0000087 CHEBI:173085 ! has role ferroptosis inducer
relationship: RO:0000087 CHEBI:25512 ! has role neurotransmitter
relationship: RO:0000087 CHEBI:27027 ! has role micronutrient
relationship: RO:0000087 CHEBI:50733 ! has role nutraceutical
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0018034 CHEBI:29985 ! is protonated form of L-glutamate(1-)
relationship: RO:0018039 CHEBI:15966 ! is enantiomer of D-glutamic acid
[Term]
id: CHEBI:16134
name: ammonia
alt_id: CHEBI:13405
alt_id: CHEBI:13406
alt_id: CHEBI:13407
alt_id: CHEBI:13771
alt_id: CHEBI:22533
alt_id: CHEBI:44269
alt_id: CHEBI:44284
alt_id: CHEBI:44404
alt_id: CHEBI:7434
def: "An azane that consists of a single nitrogen atom covelently bonded to three hydrogen atoms." []
subset: 3:STAR
synonym: "[NH3]" RELATED [molbase]
synonym: "AMMONIA" EXACT [PDBeChem]
synonym: "AMMONIA" RELATED [pdb-ccd]
synonym: "Ammonia" EXACT [KEGG_COMPOUND]
synonym: "Ammonia" RELATED [kegg.compound]
synonym: "ammonia" EXACT IUPAC:NAME [IUPAC]
synonym: "ammonia" RELATED IUPAC:NAME [iupac]
synonym: "ammoniac" RELATED [chebi]
synonym: "Ammoniak" RELATED [chemidplus]
synonym: "amoniaco" RELATED [chebi]
synonym: "azane" EXACT IUPAC:NAME [IUPAC]
synonym: "azane" RELATED IUPAC:NAME [iupac]
synonym: "NH3" RELATED [iupac, kegg.compound]
synonym: "R-717" RELATED [chebi]
synonym: "spirit of hartshorn" RELATED [chemidplus]
xref: cas:7664-41-7 {source="cas"}
xref: drugcentral:4625 {source="drugcentral"}
xref: gmelin:79 {source="gmelin"}
xref: hmdb:HMDB0000051 {source="hmdb"}
xref: kegg.compound:C00014 {source="kegg.compound"}
xref: kegg.drug:D02916 {source="kegg.drug"}
xref: knapsack:C00007267 {source="knapsack"}
xref: metacyc.compound:AMMONIA {source="metacyc.compound"}
xref: molbase:930 {source="molbase"}
xref: pdb-ccd:NH3 {source="pdb-ccd"}
xref: pubmed:110589 {source="pubmed"}
xref: pubmed:11139349 {source="pubmed"}
xref: pubmed:11540049 {source="pubmed"}
xref: pubmed:11746427 {source="pubmed"}
xref: pubmed:11783653 {source="pubmed"}
xref: pubmed:13753780 {source="pubmed"}
xref: pubmed:14663195 {source="pubmed"}
xref: pubmed:15092448 {source="pubmed"}
xref: pubmed:15094021 {source="pubmed"}
xref: pubmed:15554424 {source="pubmed"}
xref: pubmed:15969015 {source="pubmed"}
xref: pubmed:16008360 {source="pubmed"}
xref: pubmed:16050680 {source="pubmed"}
xref: pubmed:16348008 {source="pubmed"}
xref: pubmed:16349403 {source="pubmed"}
xref: pubmed:16614889 {source="pubmed"}
xref: pubmed:16664306 {source="pubmed"}
xref: pubmed:16842901 {source="pubmed"}
xref: pubmed:17025297 {source="pubmed"}
xref: pubmed:17439666 {source="pubmed"}
xref: pubmed:17569513 {source="pubmed"}
xref: pubmed:17737668 {source="pubmed"}
xref: pubmed:18670398 {source="pubmed"}
xref: pubmed:22002069 {source="pubmed"}
xref: pubmed:22081570 {source="pubmed"}
xref: pubmed:22088435 {source="pubmed"}
xref: pubmed:22100291 {source="pubmed"}
xref: pubmed:22130175 {source="pubmed"}
xref: pubmed:22150211 {source="pubmed"}
xref: pubmed:22240068 {source="pubmed"}
xref: pubmed:22290316 {source="pubmed"}
xref: pubmed:22342082 {source="pubmed"}
xref: pubmed:22385337 {source="pubmed"}
xref: pubmed:22443779 {source="pubmed"}
xref: pubmed:22560242 {source="pubmed"}
xref: reaxys:3587154 {source="reaxys"}
xref: wikipedia.en:Ammonia {source="wikipedia.en"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:138675 ! gas molecular entity
is_a: CHEBI:35107 ! azane
is_a: CHEBI:37176 ! mononuclear parent hydride
relationship: RO:0000087 CHEBI:228364 ! has role NMR chemical shift reference compound
relationship: RO:0000087 CHEBI:25212 ! has role metabolite
relationship: RO:0000087 CHEBI:50910 ! has role neurotoxin
relationship: RO:0000087 CHEBI:59740 ! has role nucleophilic reagent
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:77941 ! has role EC 3.5.1.4 (amidase) inhibitor
relationship: RO:0000087 CHEBI:78433 ! has role refrigerant
relationship: RO:0018033 CHEBI:28938 ! is deprotonated form of ammonium
relationship: RO:0018034 CHEBI:29337 ! is protonated form of azanide
[Term]
id: CHEBI:16137
name: chondroitin D-glucuronate
alt_id: CHEBI:13989
alt_id: CHEBI:13992
alt_id: CHEBI:23221
alt_id: CHEBI:3673
def: "A mucopolysaccharide composed of repeating β-D-glucopyranuronosyl-(1→3)-β-D-N-acetylgalactosaminyl units." []
subset: 3:STAR
synonym: "Chondroitin" RELATED [kegg.compound]
synonym: "Chondroitin-D-glucuronate" RELATED [kegg.compound]
xref: kegg.compound:C00401 {source="kegg.compound"}
xref: kegg.glycan:G11334 {source="kegg.glycan"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:37395 ! mucopolysaccharide
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0018034 CHEBI:57652 ! is protonated form of chondroitin D-glucuronate anion
[Term]
id: CHEBI:16189
name: sulfate
alt_id: CHEBI:15135
alt_id: CHEBI:45687
alt_id: CHEBI:9335
def: "A sulfur oxoanion obtained by deprotonation of both OH groups of sulfuric acid." []
subset: 3:STAR
synonym: "[SO4](2-)" RELATED [iupac]
synonym: "SO4(2-)" RELATED [iupac]
synonym: "Sulfate" EXACT [KEGG_COMPOUND]
synonym: "Sulfate" RELATED [kegg.compound]
synonym: "sulfate" EXACT IUPAC:NAME [IUPAC]
synonym: "sulfate" RELATED IUPAC:NAME [iupac, uniprot_ft]
synonym: "Sulfate anion(2-)" RELATED [hmdb]
synonym: "Sulfate dianion" RELATED [hmdb]
synonym: "SULFATE ION" RELATED [pdb-ccd]
synonym: "Sulfate(2-)" RELATED [hmdb]
synonym: "Sulfuric acid ion(2-)" RELATED [hmdb]
synonym: "sulphate" RELATED [chebi]
synonym: "sulphate ion" RELATED [chebi]
synonym: "tetraoxidosulfate(2-)" EXACT IUPAC:NAME [IUPAC]
synonym: "tetraoxidosulfate(2-)" RELATED IUPAC:NAME [iupac]
synonym: "tetraoxosulfate(2-)" EXACT IUPAC:NAME [IUPAC]
synonym: "tetraoxosulfate(2-)" RELATED IUPAC:NAME [iupac]
synonym: "tetraoxosulfate(VI)" EXACT IUPAC:NAME [IUPAC]
synonym: "tetraoxosulfate(VI)" RELATED IUPAC:NAME [iupac]
xref: cas:14808-79-8 {source="cas"}
xref: gmelin:2120 {source="gmelin"}
xref: hmdb:HMDB0001448 {source="hmdb"}
xref: kegg.compound:C00059 {source="kegg.compound"}
xref: kegg.drug:D05963 {source="kegg.drug"}
xref: metacyc.compound:SULFATE {source="metacyc.compound"}
xref: pdb-ccd:SO4 {source="pdb-ccd"}
xref: pubmed:11200094 {source="pubmed"}
xref: pubmed:11452993 {source="pubmed"}
xref: pubmed:11581495 {source="pubmed"}
xref: pubmed:11798107 {source="pubmed"}
xref: pubmed:12166931 {source="pubmed"}
xref: pubmed:12668033 {source="pubmed"}
xref: pubmed:14597181 {source="pubmed"}
xref: pubmed:15093386 {source="pubmed"}
xref: pubmed:15984785 {source="pubmed"}
xref: pubmed:16186560 {source="pubmed"}
xref: pubmed:16345535 {source="pubmed"}
xref: pubmed:16347366 {source="pubmed"}
xref: pubmed:16348007 {source="pubmed"}
xref: pubmed:16483812 {source="pubmed"}
xref: pubmed:16534979 {source="pubmed"}
xref: pubmed:16656509 {source="pubmed"}
xref: pubmed:16742508 {source="pubmed"}
xref: pubmed:16742518 {source="pubmed"}
xref: pubmed:17120760 {source="pubmed"}
xref: pubmed:17420092 {source="pubmed"}
xref: pubmed:17439666 {source="pubmed"}
xref: pubmed:17709180 {source="pubmed"}
xref: pubmed:18398178 {source="pubmed"}
xref: pubmed:18815700 {source="pubmed"}
xref: pubmed:18846414 {source="pubmed"}
xref: pubmed:19047345 {source="pubmed"}
xref: pubmed:19244483 {source="pubmed"}
xref: pubmed:19544990 {source="pubmed"}
xref: pubmed:19628332 {source="pubmed"}
xref: pubmed:19812358 {source="pubmed"}
xref: pubmed:30398859 {source="pubmed"}
xref: reaxys:3648446 {source="reaxys"}
xref: wikipedia.en:Sulfate {source="wikipedia.en"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:33482 ! sulfur oxoanion
is_a: CHEBI:48154 ! sulfur oxide
is_a: CHEBI:79388 ! divalent inorganic anion
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018033 CHEBI:45696 ! is deprotonated form of hydrogensulfate
[Term]
id: CHEBI:16234
name: hydroxide
alt_id: CHEBI:13365
alt_id: CHEBI:13419
alt_id: CHEBI:44641
alt_id: CHEBI:5594
subset: 3:STAR
synonym: "HO-" RELATED [kegg.compound]
synonym: "hydridooxygenate(1-)" EXACT IUPAC:NAME [IUPAC]
synonym: "hydridooxygenate(1-)" RELATED IUPAC:NAME [iupac]
synonym: "hydroxide" EXACT IUPAC:NAME [IUPAC]
synonym: "hydroxide" RELATED IUPAC:NAME [iupac]
synonym: "HYDROXIDE ION" RELATED [pdb-ccd]
synonym: "Hydroxide ion" RELATED [kegg.compound]
synonym: "OH(-)" RELATED [iupac]
synonym: "OH-" RELATED [kegg.compound]
synonym: "oxidanide" EXACT IUPAC:NAME [IUPAC]
synonym: "oxidanide" RELATED IUPAC:NAME [iupac]
xref: cas:14280-30-9 {source="cas"}
xref: gmelin:24714 {source="gmelin"}
xref: kegg.compound:C01328 {source="kegg.compound"}
xref: pdb-ccd:OH {source="pdb-ccd"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:33693 ! oxygen hydride
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0018033 CHEBI:15377 ! is deprotonated form of water
[Term]
id: CHEBI:16247
name: phospholipid
alt_id: CHEBI:14816
alt_id: CHEBI:26063
alt_id: CHEBI:8150
def: "A lipid containing phosphoric acid as a mono- or di-ester. The term encompasses phosphatidic acids and phosphoglycerides." []
subset: 3:STAR
synonym: "a phospholipid derivative" RELATED [uniprot_ft]
synonym: "Phospholipid" RELATED [kegg.compound]
synonym: "phospholipids" RELATED [chebi]
xref: kegg.compound:C00865 {source="kegg.compound"}
is_a: CHEBI:18059 ! lipid
is_a: CHEBI:25703 ! organic phosphate
is_a: CHEBI:37734 ! phosphoric ester
relationship: RO:0018034 CHEBI:62643 ! is protonated form of anionic phospholipid
[Term]
id: CHEBI:16335
name: adenosine
alt_id: CHEBI:13734
alt_id: CHEBI:22237
alt_id: CHEBI:2472
alt_id: CHEBI:40558
alt_id: CHEBI:40825
alt_id: CHEBI:40906
alt_id: CHEBI:40911
def: "A ribonucleoside composed of a molecule of adenine attached to a ribofuranose moiety via a β‒N9-glycosidic bond." []
subset: 3:STAR
synonym: "(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol" RELATED [drugbank]
synonym: "6-Amino-9-beta-D-ribofuranosyl-9H-purine" RELATED [chemidplus]
synonym: "9-beta-D-Ribofuranosidoadenine" RELATED [chemidplus]
synonym: "9-beta-D-Ribofuranosyl-9H-purin-6-amine" RELATED [chemidplus]
synonym: "9-beta-D-ribofuranosyl-9H-purin-6-amine" RELATED [chebi]
synonym: "9-beta-D-ribofuranosyladenine" RELATED [hmdb]
synonym: "Ade-Rib" RELATED [iubmb]
synonym: "adenine riboside" RELATED [hmdb]
synonym: "Adenocard" RELATED BRAND:NAME [drugbank]
synonym: "Adenocor" RELATED BRAND:NAME [drugbank]
synonym: "Adenoscan" RELATED BRAND:NAME [drugbank]
synonym: "Adenosin" RELATED [chebi]
synonym: "ADENOSINE" EXACT [PDBeChem]
synonym: "ADENOSINE" RELATED [pdb-ccd]
synonym: "Adenosine" EXACT [KEGG_COMPOUND]
synonym: "Adenosine" RELATED [kegg.compound]
synonym: "adenosine" EXACT IUPAC:NAME [IUPAC]
synonym: "adenosine" RELATED IUPAC:NAME [iupac, uniprot_ft]
synonym: "Ado" RELATED [iubmb]
synonym: "beta-D-adenosine" RELATED [chemidplus]
xref: cas:58-61-7 {source="cas"}
xref: drugbank:DB00640 {source="drugbank"}
xref: drugcentral:90 {source="drugcentral"}
xref: ecmdb:ECMDB00050 {source="ecmdb"}
xref: gmelin:53385 {source="gmelin"}
xref: hmdb:HMDB0000050 {source="hmdb"}
xref: kegg.compound:C00212 {source="kegg.compound"}
xref: kegg.drug:D00045 {source="kegg.drug"}
xref: knapsack:C00007444 {source="knapsack"}
xref: lincs.smallmolecule:LSM-28568 {source="lincs.smallmolecule"}
xref: metacyc.compound:ADENOSINE {source="metacyc.compound"}
xref: pdb-ccd:ADN {source="pdb-ccd"}
xref: pdb-ccd:ArF00 {source="pdb-ccd"}
xref: pdb-ccd:ArS00 {source="pdb-ccd"}
xref: pubmed:11213237 {source="pubmed"}
xref: pubmed:11820865 {source="pubmed"}
xref: pubmed:11978011 {source="pubmed"}
xref: pubmed:16183671 {source="pubmed"}
xref: pubmed:16917093 {source="pubmed"}
xref: pubmed:17190852 {source="pubmed"}
xref: pubmed:18000974 {source="pubmed"}
xref: pubmed:323854 {source="pubmed"}
xref: reaxys:93029 {source="reaxys"}
xref: wikipedia.en:Adenosine {source="wikipedia.en"}
xref: ymdb:YMDB00058 {source="ymdb"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:142355 ! purines D-ribonucleoside
is_a: CHEBI:22260 ! adenosines
relationship: RO:0000087 CHEBI:35480 ! has role analgesic
relationship: RO:0000087 CHEBI:35620 ! has role vasodilator agent
relationship: RO:0000087 CHEBI:38070 ! has role anti-arrhythmia drug
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
relationship: RO:0018038 CHEBI:16708 ! has functional parent adenine
[Term]
id: CHEBI:16336
name: hyaluronic acid
alt_id: CHEBI:14412
alt_id: CHEBI:24622
alt_id: CHEBI:24623
alt_id: CHEBI:30942
alt_id: CHEBI:5772
def: "A mucopolysaccharide composed of N-acetylglucosamine and glucuronic acid subunits. It is found in the connective tissues of vertebrates. A principal constituent of the extracellular matrix (ECM), it mediates the growth and metastasis of tumour cells." []
subset: 3:STAR
synonym: "[beta-D-glucopyranuronosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1->4)]n" RELATED [chebi]
synonym: "[beta-N-Acetyl-D-glucosaminyl(1,4)beta-D-glucuronosyl(1,3)]n" RELATED [kegg.compound]
synonym: "acide hyaluronique" RELATED [chebi]
synonym: "acido hialuronico" RELATED [chebi]
synonym: "hyaluronan" RELATED [chebi]
synonym: "Hyaluronic acid" RELATED [kegg.compound]
synonym: "Hyaluronsaeure" RELATED [chebi]
xref: beilstein:8538277 {source="beilstein"}
xref: cas:9004-61-9 {source="cas"}
xref: hmdb:HMDB0010366 {source="hmdb"}
xref: kegg.compound:C00518 {source="kegg.compound"}
xref: kegg.drug:D08043 {source="kegg.drug"}
xref: kegg.glycan:G10505 {source="kegg.glycan"}
xref: pubmed:11122186 {source="pubmed"}
xref: pubmed:18056362 {source="pubmed"}
xref: pubmed:18290544 {source="pubmed"}
xref: reaxys:8187837 {source="reaxys"}
xref: wikipedia.en:Hyaluronan {source="wikipedia.en"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:37395 ! mucopolysaccharide
is_a: CHEBI:72813 ! exopolysaccharide
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018034 CHEBI:132153 ! is protonated form of hyaluronate
[Term]
id: CHEBI:16526
name: carbon dioxide
alt_id: CHEBI:13282
alt_id: CHEBI:13283
alt_id: CHEBI:13284
alt_id: CHEBI:13285
alt_id: CHEBI:23011
alt_id: CHEBI:3283
alt_id: CHEBI:48829
def: "A one-carbon compound with formula CO2 in which the carbon is attached to each oxygen atom by a double bond. A colourless, odourless gas under normal conditions, it is produced during respiration by all animals, fungi and microorganisms that depend directly or indirectly on living or decaying plants for food." []
subset: 3:STAR
synonym: "[CO2]" RELATED [molbase]
synonym: "CARBON DIOXIDE" EXACT [PDBeChem]
synonym: "CARBON DIOXIDE" RELATED [pdb-ccd]
synonym: "Carbon dioxide" EXACT [KEGG_COMPOUND]
synonym: "Carbon dioxide" RELATED [kegg.compound]
synonym: "carbon dioxide" EXACT IUPAC:NAME [IUPAC]
synonym: "carbon dioxide" RELATED IUPAC:NAME [iupac]
synonym: "carbonic anhydride" RELATED [umbbd.compound]
synonym: "CO(2)" RELATED [uniprot_ft]
synonym: "CO2" RELATED [kegg.compound]
synonym: "dioxidocarbon" EXACT IUPAC:NAME [IUPAC]
synonym: "dioxidocarbon" RELATED IUPAC:NAME [iupac]
synonym: "E 290" RELATED [chebi]
synonym: "E-290" RELATED [chebi]
synonym: "E290" RELATED [chebi]
synonym: "methanedione" EXACT IUPAC:NAME [IUPAC]
synonym: "methanedione" RELATED IUPAC:NAME [iupac]
synonym: "R-744" RELATED [chebi]
xref: cas:124-38-9 {source="cas"}
xref: drugcentral:4256 {source="drugcentral"}
xref: gmelin:989 {source="gmelin"}
xref: hmdb:HMDB0001967 {source="hmdb"}
xref: kegg.compound:C00011 {source="kegg.compound"}
xref: kegg.drug:D00004 {source="kegg.drug"}
xref: metacyc.compound:CARBON-DIOXIDE {source="metacyc.compound"}
xref: molbase:752 {source="molbase"}
xref: pdb-ccd:CO2 {source="pdb-ccd"}
xref: ppdb:119 {source="ppdb"}
xref: pubmed:10826146 {source="pubmed"}
xref: pubmed:11094503 {source="pubmed"}
xref: pubmed:11584085 {source="pubmed"}
xref: pubmed:11802652 {source="pubmed"}
xref: pubmed:14639145 {source="pubmed"}
xref: pubmed:15050588 {source="pubmed"}
xref: pubmed:16591971 {source="pubmed"}
xref: pubmed:16656478 {source="pubmed"}
xref: pubmed:16659660 {source="pubmed"}
xref: pubmed:17190796 {source="pubmed"}
xref: pubmed:17448243 {source="pubmed"}
xref: pubmed:17878298 {source="pubmed"}
xref: pubmed:17884085 {source="pubmed"}
xref: pubmed:19043767 {source="pubmed"}
xref: pubmed:19259576 {source="pubmed"}
xref: pubmed:19854893 {source="pubmed"}
xref: pubmed:23384758 {source="pubmed"}
xref: pubmed:23828359 {source="pubmed"}
xref: pubmed:24258718 {source="pubmed"}
xref: pubmed:8482095 {source="pubmed"}
xref: pubmed:8818713 {source="pubmed"}
xref: pubmed:8869828 {source="pubmed"}
xref: pubmed:9611769 {source="pubmed"}
xref: pubmed:9730350 {source="pubmed"}
xref: reaxys:1900390 {source="reaxys"}
xref: umbbd.compound:c0131 {source="umbbd.compound"}
xref: wikipedia.en:Carbon_dioxide {source="wikipedia.en"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:138675 ! gas molecular entity
is_a: CHEBI:23014 ! carbon oxide
is_a: CHEBI:64708 ! one-carbon compound
relationship: RO:0000087 CHEBI:35620 ! has role vasodilator agent
relationship: RO:0000087 CHEBI:38867 ! has role anaesthetic
relationship: RO:0000087 CHEBI:46787 ! has role solvent
relationship: RO:0000087 CHEBI:48706 ! has role antagonist
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76413 ! has role greenhouse gas
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0000087 CHEBI:77974 ! has role food packaging gas
relationship: RO:0000087 CHEBI:78017 ! has role food propellant
relationship: RO:0000087 CHEBI:78433 ! has role refrigerant
[Term]
id: CHEBI:16541
name: protein polypeptide chain
alt_id: CHEBI:8526
def: "A naturally occurring polypeptide synthesized at the ribosome." []
subset: 3:STAR
synonym: "a protein" RELATED [uniprot_ft]
synonym: "polypeptide chain" RELATED [chebi]
synonym: "Protein" RELATED [kegg.compound]
synonym: "protein polypeptide chains" RELATED [chebi]
xref: kegg.compound:C00017 {source="kegg.compound"}
is_a: CHEBI:15841 ! polypeptide
relationship: has_part CHEBI:33700 ! proteinogenic amino-acid residue
[Term]
id: CHEBI:16646
name: carbohydrate
alt_id: CHEBI:15131
alt_id: CHEBI:23008
alt_id: CHEBI:9318
def: "Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula Cm(H2O)n. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates." []
subset: 3:STAR
synonym: "a carbohydrate" RELATED [uniprot_ft]
synonym: "carbohidrato" RELATED [iupac]
synonym: "carbohidratos" RELATED [iupac]
synonym: "carbohydrate" EXACT IUPAC:NAME [IUPAC]
synonym: "carbohydrate" RELATED IUPAC:NAME [iupac]
synonym: "carbohydrates" EXACT IUPAC:NAME [IUPAC]
synonym: "carbohydrates" RELATED IUPAC:NAME [iupac]
synonym: "glucide" RELATED [chebi]
synonym: "glucides" RELATED [chebi]
synonym: "glucido" RELATED [chebi]
synonym: "glucidos" RELATED [chebi]
synonym: "hydrates de carbone" RELATED [chebi]
synonym: "Kohlenhydrat" RELATED [chebi]
synonym: "Kohlenhydrate" RELATED [chebi]
synonym: "saccharide" RELATED [iupac]
synonym: "saccharides" RELATED [iupac]
synonym: "saccharidum" RELATED [chebi]
xref: wikipedia.en:Carbohydrate {source="wikipedia.en"}
is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives
[Term]
id: CHEBI:16666
name: prephenic acid
alt_id: CHEBI:26257
alt_id: CHEBI:45028
alt_id: CHEBI:8399
def: "An oxo dicarboxylic acid that consists of 4-hydroxycyclohexa-2,5-diene-1-carboxylic acid substituted by a 2-carboxy-2-oxoethyl group at position 1." []
subset: 3:STAR
synonym: "1-Carboxy-4-hydroxy-2,5-cyclohexadiene-1-pyruvic acid" RELATED [chemidplus]
synonym: "1-carboxy-4-hydroxy-alpha-oxo-2,5-cyclohexadiene-1-propanoic acid" RELATED [chemidplus]
synonym: "PREPHENIC ACID" RELATED [pdb-ccd]
synonym: "Prephenic acid" RELATED [kegg.compound]
xref: agr:IND44654981 {source="agr"}
xref: cas:126-49-8 {source="cas"}
xref: drugbank:DB08427 {source="drugbank"}
xref: hmdb:HMDB0012283 {source="hmdb"}
xref: knapsack:C00019632 {source="knapsack"}
xref: pdb-ccd:PRE {source="pdb-ccd"}
xref: pubmed:1156090 {source="pubmed"}
xref: pubmed:13363412 {source="pubmed"}
xref: pubmed:14185725 {source="pubmed"}
xref: pubmed:155813 {source="pubmed"}
xref: reaxys:2698270 {source="reaxys"}
xref: wikipedia.en:Prephenic_acid {source="wikipedia.en"}
is_a: CHEBI:36145 ! oxo dicarboxylic acid
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0018034 CHEBI:29934 ! is protonated form of (1s,4s)-prephenate(2-)
relationship: RO:0018034 CHEBI:57852 ! is protonated form of prephenate(2-)
[Term]
id: CHEBI:16670
name: peptide
alt_id: CHEBI:14753
alt_id: CHEBI:25906
alt_id: CHEBI:7990
def: "Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from α-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc." []
subset: 3:STAR
synonym: "Peptid" RELATED [chebi]
synonym: "Peptide" RELATED [kegg.compound]
synonym: "peptides" EXACT IUPAC:NAME [IUPAC]
synonym: "peptides" RELATED IUPAC:NAME [iupac]
synonym: "peptido" RELATED [chebi]
synonym: "peptidos" RELATED [chebi]
xref: kegg.compound:C00012 {source="kegg.compound"}
is_a: CHEBI:37622 ! carboxamide
is_a: CHEBI:50047 ! organic amino compound
relationship: has_part CHEBI:33708 ! amino-acid residue
relationship: RO:0018036 CHEBI:60466 ! is tautomer of peptide zwitterion
[Term]
id: CHEBI:166902
name: noradrenaline(1+)
def: "An organic cation that is the conjugate acid of noradrenaline, obtained by protonation of the primary amino group; major species at pH 7.3." []
subset: 3:STAR
synonym: "2-(3,4-dihydroxyphenyl)-2-hydroxyethan-1-aminium" RELATED [iupac]
synonym: "2-(3,4-dihydroxyphenyl)-2-hydroxyethanaminium" EXACT IUPAC:NAME [IUPAC]
synonym: "2-(3,4-dihydroxyphenyl)-2-hydroxyethanaminium" RELATED IUPAC:NAME [iupac]
synonym: "noradrenaline" RELATED [uniprot_ft]
synonym: "noradrenaline cation" RELATED [chebi]
synonym: "norepinephrine cation" RELATED [chebi]
synonym: "norepinephrine(1+)" RELATED [chebi]
is_a: CHEBI:25697 ! organic cation
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: RO:0018034 CHEBI:33569 ! is protonated form of noradrenaline
[Term]
id: CHEBI:16701
name: nucleoside 5'-phosphate
alt_id: CHEBI:14674
alt_id: CHEBI:25603
alt_id: CHEBI:7650
def: "A ribosyl or deoxyribosyl derivative of a pyrimidine or purine base in which C-5 of the ribose ring is mono-, di-, tri- or tetra-phosphorylated." []
subset: 3:STAR
synonym: "Nucleoside 5'-phosphate" RELATED [kegg.compound]
synonym: "nucleoside 5'-phosphates" RELATED [chebi]
xref: kegg.compound:C01117 {source="kegg.compound"}
is_a: CHEBI:29075 ! mononucleotide
relationship: RO:0018034 CHEBI:57867 ! is protonated form of nucleoside 5'-phosphate dianion
[Term]
id: CHEBI:16708
name: adenine
alt_id: CHEBI:13733
alt_id: CHEBI:22236
alt_id: CHEBI:2470
alt_id: CHEBI:40579
def: "The parent compound of the 6-aminopurines, composed of a purine having an amino group at C-6." []
subset: 3:STAR
synonym: "6-Aminopurine" RELATED [kegg.compound]
synonym: "9H-purin-6-amine" EXACT IUPAC:NAME [IUPAC]
synonym: "9H-purin-6-amine" RELATED IUPAC:NAME [iupac]
synonym: "A" RELATED [chebi]
synonym: "Ade" RELATED [iubmb]
synonym: "Adenin" RELATED [nist]
synonym: "ADENINE" RELATED [pdb-ccd]
synonym: "Adenine" RELATED [kegg.compound]
synonym: "adenine" RELATED [uniprot_ft]
xref: cas:73-24-5 {source="cas"}
xref: drugbank:DB00173 {source="drugbank"}
xref: drugcentral:89 {source="drugcentral"}
xref: gmelin:3903 {source="gmelin"}
xref: hmdb:HMDB0000034 {source="hmdb"}
xref: kegg.compound:C00147 {source="kegg.compound"}
xref: kegg.drug:D00034 {source="kegg.drug"}
xref: knapsack:C00001490 {source="knapsack"}
xref: metacyc.compound:ADENINE {source="metacyc.compound"}
xref: pdb-ccd:ADE {source="pdb-ccd"}
xref: pubmed:11985597 {source="pubmed"}
xref: pubmed:12829005 {source="pubmed"}
xref: pubmed:12951489 {source="pubmed"}
xref: pubmed:15063338 {source="pubmed"}
xref: pubmed:15715490 {source="pubmed"}
xref: pubmed:17439666 {source="pubmed"}
xref: pubmed:8070089 {source="pubmed"}
xref: reaxys:608603 {source="reaxys"}
xref: wikipedia.en:Adenine {source="wikipedia.en"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:20706 ! 6-aminopurines
is_a: CHEBI:26386 ! purine nucleobase
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0000087 CHEBI:83056 ! has role Daphnia magna metabolite
relationship: RO:0018040 CHEBI:35589 ! has parent hydride 9H-purine
[Term]
id: CHEBI:16716
name: benzene
alt_id: CHEBI:13876
alt_id: CHEBI:22703
alt_id: CHEBI:3025
alt_id: CHEBI:41187
def: "A six-carbon aromatic annulene in which each carbon atom donates one of its two 2p electrons into a delocalised π system. A toxic, flammable liquid byproduct of coal distillation, it is used as an industrial solvent. Benzene is a carcinogen that also damages bone marrow and the central nervous system." []
subset: 3:STAR
synonym: "[6]annulene" RELATED [nist]
synonym: "Benzen" RELATED [iupac]
synonym: "BENZENE" EXACT [PDBeChem]
synonym: "BENZENE" RELATED [pdb-ccd]
synonym: "Benzene" EXACT [KEGG_COMPOUND]
synonym: "Benzene" RELATED [kegg.compound]
synonym: "benzene" EXACT IUPAC:NAME [IUPAC]
synonym: "benzene" RELATED IUPAC:NAME [chebi, iupac, uniprot_ft]
synonym: "Benzine" RELATED [umbbd.compound]
synonym: "Benzol" RELATED [chemidplus]
synonym: "benzole" RELATED [nist]
synonym: "Bicarburet of hydrogen" RELATED [chemidplus]
synonym: "Coal naphtha" RELATED [chemidplus]
synonym: "cyclohexatriene" RELATED [umbbd.compound]
synonym: "Mineral naphtha" RELATED [chemidplus]
synonym: "Phene" RELATED [chemidplus]
synonym: "phenyl hydride" RELATED [umbbd.compound]
synonym: "Pyrobenzol" RELATED [chemidplus]
synonym: "Pyrobenzole" RELATED [chemidplus]
xref: cas:71-43-2 {source="cas"}
xref: gmelin:1671 {source="gmelin"}
xref: hmdb:HMDB0001505 {source="hmdb"}
xref: kegg.compound:C01407 {source="kegg.compound"}
xref: pdb-ccd:BNZ {source="pdb-ccd"}
xref: pubmed:11684179 {source="pubmed"}
xref: pubmed:11993966 {source="pubmed"}
xref: pubmed:12857942 {source="pubmed"}
xref: pubmed:14677922 {source="pubmed"}
xref: pubmed:15468289 {source="pubmed"}
xref: pubmed:15935818 {source="pubmed"}
xref: pubmed:16161967 {source="pubmed"}
xref: pubmed:17373369 {source="pubmed"}
xref: pubmed:18072742 {source="pubmed"}
xref: pubmed:18407866 {source="pubmed"}
xref: pubmed:18409691 {source="pubmed"}
xref: pubmed:18836923 {source="pubmed"}
xref: pubmed:19228219 {source="pubmed"}
xref: pubmed:21325737 {source="pubmed"}
xref: pubmed:23088855 {source="pubmed"}
xref: pubmed:23222815 {source="pubmed"}
xref: pubmed:23534829 {source="pubmed"}
xref: pubmed:6353911 {source="pubmed"}
xref: pubmed:8124204 {source="pubmed"}
xref: reaxys:969212 {source="reaxys"}
xref: umbbd.compound:c0142 {source="umbbd.compound"}
xref: wikipedia.en:Benzene {source="wikipedia.en"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:134179 ! volatile organic compound
is_a: CHEBI:22712 ! benzenes
is_a: CHEBI:33842 ! aromatic annulene
relationship: RO:0000087 CHEBI:48355 ! has role non-polar solvent
relationship: RO:0000087 CHEBI:50903 ! has role carcinogenic agent
relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant
[Term]
id: CHEBI:167164
name: mineral nutrient
def: "A mineral that is an inorganic nutrient which must be ingested and absorbed in adequate amounts to satisfy a wide range of essential metabolic and/or structural functions in the human body." []
subset: 3:STAR
synonym: "mineral nutrient" RELATED [chebi]
synonym: "mineral nutrients" RELATED [chebi]
synonym: "nutrient mineral" RELATED [chebi]
synonym: "nutrient minerals" RELATED [chebi]
xref: wikipedia.en:Mineral_(nutrient) {source="wikipedia.en"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:46662 ! mineral
relationship: RO:0000087 CHEBI:33284 ! has role nutrient
[Term]
id: CHEBI:16733
name: D-alpha-amino acid
alt_id: CHEBI:12909
alt_id: CHEBI:13625
alt_id: CHEBI:20906
alt_id: CHEBI:4097
subset: 3:STAR
synonym: "D-alpha-amino acid" RELATED [chebi]
synonym: "D-alpha-amino acids" EXACT IUPAC:NAME [IUPAC]
synonym: "D-alpha-amino acids" RELATED IUPAC:NAME [chebi, iupac]
synonym: "D-Amino acid" RELATED [kegg.compound]
xref: kegg.compound:C00405 {source="kegg.compound"}
is_a: CHEBI:83925 ! non-proteinogenic alpha-amino acid
relationship: RO:0018034 CHEBI:60895 ! is protonated form of D-alpha-amino acid anion
relationship: RO:0018036 CHEBI:59871 ! is tautomer of D-alpha-amino acid zwitterion
[Term]
id: CHEBI:167559
name: glycan
def: "Any oligosaccharide, polysaccharide or their derivatives consisting of monosaccharides or monosaccharide derivatives linked by glycosidic bonds. See also http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001." []
subset: 3:STAR
synonym: "glycans" RELATED [chebi]
is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives
[Term]
id: CHEBI:16761
name: ADP
alt_id: CHEBI:13222
alt_id: CHEBI:22244
alt_id: CHEBI:2342
alt_id: CHEBI:40553
def: "A purine ribonucleoside 5'-diphosphate having adenine as the nucleobase." []
subset: 3:STAR
synonym: "5'-adenylphosphoric acid" RELATED [chemidplus]
synonym: "adenosine 5'-(trihydrogen diphosphate)" EXACT IUPAC:NAME [IUPAC]
synonym: "adenosine 5'-(trihydrogen diphosphate)" RELATED IUPAC:NAME [iupac]
synonym: "Adenosine 5'-diphosphate" EXACT [KEGG_COMPOUND]
synonym: "Adenosine 5'-diphosphate" RELATED [kegg.compound]
synonym: "ADENOSINE-5'-DIPHOSPHATE" RELATED [pdb-ccd]
synonym: "ADP" RELATED [kegg.compound]
synonym: "H3adp" RELATED [iupac]
xref: cas:20398-34-9 {source="cas"}
xref: cas:58-64-0 {source="cas"}
xref: drugbank:DB03431 {source="drugbank"}
xref: gmelin:88452 {source="gmelin"}
xref: kegg.compound:C00008 {source="kegg.compound"}
xref: kegg.glycan:G11113 {source="kegg.glycan"}
xref: knapsack:C00019353 {source="knapsack"}
xref: pdb-ccd:ADP {source="pdb-ccd"}
xref: pubmed:16295522 {source="pubmed"}
xref: reaxys:67722 {source="reaxys"}
is_a: CHEBI:37038 ! purine ribonucleoside 5'-diphosphate
is_a: CHEBI:37096 ! adenosine 5'-phosphate
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
relationship: RO:0018034 CHEBI:456216 ! is protonated form of ADP(3-)
relationship: RO:0018034 CHEBI:87518 ! is protonated form of ADP(2-)
[Term]
id: CHEBI:16765
name: tryptamine
alt_id: CHEBI:15274
alt_id: CHEBI:27161
alt_id: CHEBI:46157
alt_id: CHEBI:9767
def: "An aminoalkylindole consisting of indole having a 2-aminoethyl group at the 3-position." []
subset: 3:STAR
synonym: "1H-indole-3-ethanamine" RELATED [nist]
synonym: "2-(1H-INDOL-3-YL)ETHANAMINE" EXACT [PDBeChem]
synonym: "2-(1H-INDOL-3-YL)ETHANAMINE" RELATED [pdb-ccd]
synonym: "2-(1H-indol-3-yl)ethanamine" EXACT IUPAC:NAME [IUPAC]
synonym: "2-(1H-indol-3-yl)ethanamine" RELATED IUPAC:NAME [iupac]
synonym: "2-(3-indolyl)ethylamine" RELATED [chemidplus]
synonym: "3-(2-Aminoethyl)indole" RELATED [kegg.compound]
synonym: "Tryptamine" RELATED [kegg.compound]
xref: cas:61-54-1 {source="cas"}
xref: drugbank:DB08653 {source="drugbank"}
xref: gmelin:603448 {source="gmelin"}
xref: hmdb:HMDB0000303 {source="hmdb"}
xref: kegg.compound:C00398 {source="kegg.compound"}
xref: knapsack:C00001434 {source="knapsack"}
xref: metacyc.compound:TRYPTAMINE {source="metacyc.compound"}
xref: pdb-ccd:TSS {source="pdb-ccd"}
xref: pubmed:16126914 {source="pubmed"}
xref: pubmed:22770225 {source="pubmed"}
xref: pubmed:24345948 {source="pubmed"}
xref: pubmed:24558969 {source="pubmed"}
xref: reaxys:125513 {source="reaxys"}
xref: wikipedia.en:Tryptamine {source="wikipedia.en"}
is_a: CHEBI:27162 ! tryptamines
is_a: CHEBI:38631 ! aminoalkylindole
is_a: CHEBI:38958 ! indole alkaloid
is_a: CHEBI:64365 ! aralkylamino compound
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018033 CHEBI:57887 ! is deprotonated form of tryptaminium
[Term]
id: CHEBI:16796
name: melatonin
alt_id: CHEBI:14577
alt_id: CHEBI:25180
alt_id: CHEBI:6730
def: "A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans." []
subset: 3:STAR
synonym: "5-methoxy-N-acetyltryptamine" RELATED [chemidplus]
synonym: "Melatonin" RELATED [kegg.compound]
synonym: "melatonin" RELATED [uniprot_ft]
synonym: "melatonine" RELATED [chebi]
synonym: "N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide" EXACT IUPAC:NAME [IUPAC]
synonym: "N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide" RELATED IUPAC:NAME [iupac]
synonym: "N-[2-(5-methoxyindol-3-yl)ethyl]acetamide" RELATED [nist]
synonym: "N-Acetyl-5-methoxytryptamine" RELATED [kegg.compound]
xref: cas:73-31-4 {source="cas"}
xref: drugbank:DB01065 {source="drugbank"}
xref: drugcentral:1672 {source="drugcentral"}
xref: hmdb:HMDB0001389 {source="hmdb"}
xref: kegg.compound:C01598 {source="kegg.compound"}
xref: kegg.drug:D08170 {source="kegg.drug"}
xref: lincs.smallmolecule:LSM-4779 {source="lincs.smallmolecule"}
xref: metacyc.compound:N-ACETYL-5-METHOXY-TRYPTAMINE {source="metacyc.compound"}
xref: pdb-ccd:ML1 {source="pdb-ccd"}
xref: pubmed:16678784 {source="pubmed"}
xref: pubmed:18212404 {source="pubmed"}
xref: pubmed:18485664 {source="pubmed"}
xref: pubmed:8290600 {source="pubmed"}
xref: reaxys:205542 {source="reaxys"}
xref: wikipedia.en:Melatonin {source="wikipedia.en"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:22160 ! acetamides
is_a: CHEBI:27162 ! tryptamines
relationship: RO:0000087 CHEBI:176497 ! has role geroprotector
relationship: RO:0000087 CHEBI:24621 ! has role hormone
relationship: RO:0000087 CHEBI:35488 ! has role central nervous system depressant
relationship: RO:0000087 CHEBI:35623 ! has role anticonvulsant
relationship: RO:0000087 CHEBI:48578 ! has role radical scavenger
relationship: RO:0000087 CHEBI:50847 ! has role immunological adjuvant
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018038 CHEBI:16765 ! has functional parent tryptamine
[Term]
id: CHEBI:16862
name: nucleoside 5'-diphosphate
alt_id: CHEBI:13401
alt_id: CHEBI:13662
alt_id: CHEBI:14675
alt_id: CHEBI:18181
alt_id: CHEBI:25606
alt_id: CHEBI:7428
alt_id: CHEBI:7652
subset: 3:STAR
synonym: "NDP" RELATED [kegg.compound]
synonym: "Nucleoside diphosphate" RELATED [kegg.compound]
synonym: "nucleoside diphosphates" RELATED [chebi]
xref: kegg.compound:C00454 {source="kegg.compound"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:25608 ! nucleoside phosphate
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0018034 CHEBI:57930 ! is protonated form of nucleoside 5'-diphosphate(3-)
[Term]
id: CHEBI:16865
name: gamma-aminobutyric acid
alt_id: CHEBI:1786
alt_id: CHEBI:193777
alt_id: CHEBI:20318
alt_id: CHEBI:40483
def: "A γ-amino acid that is butanoic acid with the amino substituent located at C-4." []
subset: 3:STAR
synonym: "4-Aminobutanoic acid" EXACT [KEGG_COMPOUND]
synonym: "4-Aminobutanoic acid" RELATED [kegg.compound]
synonym: "4-aminobutanoic acid" EXACT IUPAC:NAME [ChEBI, IUPAC]
synonym: "4-aminobutanoic acid" RELATED IUPAC:NAME [chebi, iupac]
synonym: "4-Aminobutyric acid" RELATED [kegg.compound]
synonym: "4-aminobutyric acid" RELATED [chebi]
synonym: "4Abu" RELATED [chebi]
synonym: "GABA" RELATED [iuphar, kegg.compound]
synonym: "GAMMA-AMINO-BUTANOIC ACID" RELATED [pdb-ccd]
synonym: "gamma-amino-n-butyric acid" RELATED [nist]
synonym: "gamma-aminobutanoic acid" RELATED [nist]
synonym: "gamma-Aminobuttersaeure" RELATED [nist]
synonym: "gamma-Aminobutyric acid" RELATED [kegg.compound]
synonym: "gamma-aminobutyric acid" RELATED [nist]
synonym: "omega-aminobutyric acid" RELATED [nist]
synonym: "piperidic acid" RELATED [chemidplus]
synonym: "piperidinic acid" RELATED [chemidplus]
xref: bpdb:2298 {source="bpdb"}
xref: cas:56-12-2 {source="cas"}
xref: drugbank:DB02530 {source="drugbank"}
xref: drugcentral:1262 {source="drugcentral"}
xref: gmelin:49775 {source="gmelin"}
xref: hmdb:HMDB0000112 {source="hmdb"}
xref: kegg.compound:C00334 {source="kegg.compound"}
xref: kegg.drug:D00058 {source="kegg.drug"}
xref: knapsack:C00001337 {source="knapsack"}
xref: lipidmaps:LMFA01100039 {source="lipidmaps"}
xref: metacyc.compound:4-AMINO-BUTYRATE {source="metacyc.compound"}
xref: pdb-ccd:ABU {source="pdb-ccd"}
xref: pubmed:10630630 {source="pubmed"}
xref: pubmed:10930630 {source="pubmed"}
xref: pubmed:16276116 {source="pubmed"}
xref: pubmed:21614609 {source="pubmed"}
xref: pubmed:22770225 {source="pubmed"}
xref: reaxys:906818 {source="reaxys"}
xref: wikipedia.en:Gamma-Aminobutyric_acid {source="wikipedia.en"}
is_a: CHEBI:25384 ! monocarboxylic acid
is_a: CHEBI:33707 ! gamma-amino acid
relationship: RO:0000087 CHEBI:25512 ! has role neurotransmitter
relationship: RO:0000087 CHEBI:62488 ! has role signalling molecule
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018034 CHEBI:30566 ! is protonated form of gamma-aminobutyrate
relationship: RO:0018036 CHEBI:59888 ! is tautomer of gamma-aminobutyric acid zwitterion
relationship: RO:0018038 CHEBI:30772 ! has functional parent butyric acid
[Term]
id: CHEBI:16988
name: D-ribose
alt_id: CHEBI:13011
alt_id: CHEBI:21078
def: "A ribose in which the chiral carbon atom furthest away from the aldehyde group (C4') has the same configuration as in D-glyceraldehyde." []
subset: 3:STAR
synonym: "D-Rib" RELATED [jcbn]
synonym: "D-ribo-pentose" EXACT IUPAC:NAME [IUPAC]
synonym: "D-ribo-pentose" RELATED IUPAC:NAME [iupac]
synonym: "D-ribose" EXACT IUPAC:NAME [IUPAC]
synonym: "D-ribose" RELATED IUPAC:NAME [iupac]
xref: drugbank:DB01936 {source="drugbank"}
xref: pubmed:24404872 {source="pubmed"}
xref: pubmed:24752650 {source="pubmed"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:33942 ! ribose
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
relationship: RO:0018039 CHEBI:46997 ! is enantiomer of L-ribose
[Term]
id: CHEBI:16990
name: bilirubin IXalpha
alt_id: CHEBI:13898
alt_id: CHEBI:22870
alt_id: CHEBI:3099
def: "A member of the class of biladienes that is a linear tetrapyrrole with the dipyrrole units being of both exovinyl and endovinyl type. A product of heme degradation, it is produced in the reticuloendothelial system by the reduction of biliverdin and transported to the liver as a complex with serum albumin." []
subset: 3:STAR
synonym: "1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinylbiline-8,12-dipropionic acid" RELATED [chemidplus]
synonym: "2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid" RELATED [chemidplus]
synonym: "2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoic acid" RELATED [iupac]
synonym: "3,18-diethenyl-2,7,13,17-tetramethyl-1,19-dioxo-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoic acid" EXACT IUPAC:NAME [IUPAC]
synonym: "3,18-diethenyl-2,7,13,17-tetramethyl-1,19-dioxo-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoic acid" RELATED IUPAC:NAME [iupac]
synonym: "8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-3,18-divinylbiladiene-ac-1,19(21H,24H)-dione" RELATED [jcbn]
synonym: "Bilirubin" EXACT [KEGG_COMPOUND]
synonym: "Bilirubin" RELATED [kegg.compound]
synonym: "bilirubin" EXACT IUPAC:NAME [IUPAC]
synonym: "bilirubin" RELATED IUPAC:NAME [iupac]
synonym: "bilirubin(Z,Z)" RELATED [chebi]
synonym: "bilirubin-IXalpha" RELATED [chebi]
xref: cas:635-65-4 {source="cas"}
xref: gmelin:411033 {source="gmelin"}
xref: hmdb:HMDB0000054 {source="hmdb"}
xref: kegg.compound:C00486 {source="kegg.compound"}
xref: knapsack:C00029828 {source="knapsack"}
xref: metacyc.compound:BILIRUBIN {source="metacyc.compound"}
xref: pdb-ccd:BLR {source="pdb-ccd"}
xref: pubmed:12799017 {source="pubmed"}
xref: pubmed:18442622 {source="pubmed"}
xref: pubmed:23763371 {source="pubmed"}
xref: pubmed:23768684 {source="pubmed"}
xref: pubmed:30224965 {source="pubmed"}
xref: pubmed:8605219 {source="pubmed"}
xref: pubmed:9587403 {source="pubmed"}
xref: reaxys:74376 {source="reaxys"}
xref: wikipedia.en:Bilirubin {source="wikipedia.en"}
is_a: CHEBI:35692 ! dicarboxylic acid
is_a: CHEBI:36735 ! biladienes
relationship: has_part CHEBI:142163 ! 24G7 epitope
relationship: RO:0000087 CHEBI:22586 ! has role antioxidant
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018034 CHEBI:57977 ! is protonated form of bilirubin(2-)
[Term]
id: CHEBI:16991
name: deoxyribonucleic acid
alt_id: CHEBI:13302
alt_id: CHEBI:21123
alt_id: CHEBI:33698
alt_id: CHEBI:4291
def: "High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms." []
subset: 3:STAR
synonym: "(Deoxyribonucleotide)m" RELATED [kegg.compound]
synonym: "(Deoxyribonucleotide)n" RELATED [kegg.compound]
synonym: "(Deoxyribonucleotide)n+m" RELATED [kegg.compound]
synonym: "Deoxyribonucleic acid" RELATED [kegg.compound]
synonym: "deoxyribonucleic acids" EXACT IUPAC:NAME [IUPAC]
synonym: "deoxyribonucleic acids" RELATED IUPAC:NAME [chebi, iupac]
synonym: "Desoxyribonukleinsaeure" RELATED [chebi]
synonym: "desoxyribose nucleic acid" RELATED [chemidplus]
synonym: "DNA" RELATED [iupac, kegg.compound, uniprot_ft]
synonym: "DNAn" RELATED [kegg.compound]
synonym: "DNAn+1" RELATED [kegg.compound]
synonym: "DNS" RELATED [chebi]
synonym: "thymus nucleic acid" RELATED [chebi]
xref: cas:9007-49-2 {source="cas"}
xref: kegg.compound:C00039 {source="kegg.compound"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:33696 ! nucleic acid
relationship: has_part CHEBI:33793 ! canonical deoxyribonucleoside residue
relationship: has_part CHEBI:50298 ! canonical deoxyribonucleotide residue
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
[Term]
id: CHEBI:16998
name: D-phenylalanine
alt_id: CHEBI:13007
alt_id: CHEBI:21067
alt_id: CHEBI:42207
alt_id: CHEBI:4224
def: "The D-enantiomer of phenylalanine." []
subset: 3:STAR
synonym: "(2R)-2-amino-3-phenylpropanoic acid" EXACT IUPAC:NAME [IUPAC]
synonym: "(2R)-2-amino-3-phenylpropanoic acid" RELATED IUPAC:NAME [iupac]
synonym: "D-alpha-Amino-beta-phenylpropionic acid" RELATED [kegg.compound]
synonym: "D-Phe" RELATED [chebi]
synonym: "D-PHENYLALANINE" EXACT [PDBeChem]
synonym: "D-PHENYLALANINE" RELATED [pdb-ccd]
synonym: "D-Phenylalanine" EXACT [KEGG_COMPOUND]
synonym: "D-Phenylalanine" RELATED [kegg.compound]
synonym: "D-phenylalanine" EXACT IUPAC:NAME [IUPAC]
synonym: "D-phenylalanine" RELATED IUPAC:NAME [iupac]
synonym: "DPN" RELATED [pdb-ccd]
synonym: "phenylalanine D-form" RELATED [chemidplus]
xref: cas:673-06-3 {source="cas"}
xref: drugbank:DB02556 {source="drugbank"}
xref: ecmdb:ECMDB20144 {source="ecmdb"}
xref: gmelin:83219 {source="gmelin"}
xref: kegg.compound:C02265 {source="kegg.compound"}
xref: metacyc.compound:CPD-216 {source="metacyc.compound"}
xref: pdb-ccd:DPN {source="pdb-ccd"}
xref: pubmed:22382026 {source="pubmed"}
xref: pubmed:22397264 {source="pubmed"}
xref: pubmed:24464217 {source="pubmed"}
xref: pubmed:7114516 {source="pubmed"}
xref: reaxys:2804068 {source="reaxys"}
xref: ymdb:YMDB00995 {source="ymdb"}
is_a: CHEBI:16733 ! D-alpha-amino acid
is_a: CHEBI:28044 ! phenylalanine
relationship: RO:0018033 CHEBI:32495 ! is deprotonated form of D-phenylalaninium
relationship: RO:0018034 CHEBI:32494 ! is protonated form of D-phenylalaninate
relationship: RO:0018036 CHEBI:57981 ! is tautomer of D-phenylalanine zwitterion
relationship: RO:0018039 CHEBI:17295 ! is enantiomer of L-phenylalanine
[Term]
id: CHEBI:17026
name: progesterone
alt_id: CHEBI:14896
alt_id: CHEBI:18798
alt_id: CHEBI:26269
alt_id: CHEBI:28589
alt_id: CHEBI:439
alt_id: CHEBI:45786
alt_id: CHEBI:8453
def: "A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species." []
subset: 3:STAR
synonym: "(S)-4-Pregnene-3,20-dione" RELATED [kegg.compound]
synonym: "(S)-Pregn-4-en-3,20-dione" RELATED [kegg.compound]
synonym: "(S)-Progesterone" RELATED [kegg.compound]
synonym: "17alpha-progesterone" RELATED [nist]
synonym: "4-Pregnene-3,20-dione" RELATED [kegg.compound]
synonym: "Agolutin" RELATED [nist]
synonym: "Akrolutin" RELATED [chebi]
synonym: "corpus luteum hormone" RELATED [chemidplus]
synonym: "Crinone" RELATED [chemidplus]
synonym: "Delta(4)-pregnene-3,20-dione" RELATED [chebi]
synonym: "Gelbkoerperhormon" RELATED [chebi]
synonym: "luteohormone" RELATED [chemidplus]
synonym: "pregn-4-ene-3,20-dione" EXACT IUPAC:NAME [IUPAC]
synonym: "pregn-4-ene-3,20-dione" RELATED IUPAC:NAME [iupac]
synonym: "Progesteron" RELATED [chebi]
synonym: "PROGESTERONE" RELATED [pdb-ccd]
synonym: "Progesterone" RELATED [kegg.compound]
synonym: "progesterone" RELATED [uniprot_ft]
xref: cas:57-83-0 {source="cas"}
xref: drugbank:DB00396 {source="drugbank"}
xref: drugcentral:2279 {source="drugcentral"}
xref: gmelin:708590 {source="gmelin"}
xref: hmdb:HMDB0001830 {source="hmdb"}
xref: kegg.compound:C00410 {source="kegg.compound"}
xref: kegg.drug:D00066 {source="kegg.drug"}
xref: metacyc.compound:PROGESTERONE {source="metacyc.compound"}
xref: pdb-ccd:STR {source="pdb-ccd"}
xref: pubmed:10438974 {source="pubmed"}
xref: pubmed:9506942 {source="pubmed"}
xref: reaxys:1915950 {source="reaxys"}
xref: wikipedia.en:Progesterone {source="wikipedia.en"}
is_a: CHEBI:36885 ! 20-oxo steroid
is_a: CHEBI:47909 ! 3-oxo-Delta(4) steroid
is_a: CHEBI:64600 ! C21-steroid hormone
relationship: RO:0000087 CHEBI:49323 ! has role contraceptive drug
relationship: RO:0000087 CHEBI:59826 ! has role progestin
relationship: RO:0000087 CHEBI:70709 ! has role progesterone receptor agonist
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018040 CHEBI:8386 ! has parent hydride pregnane
[Term]
id: CHEBI:17029
name: chitin
alt_id: CHEBI:13962
alt_id: CHEBI:23099
alt_id: CHEBI:3596
def: "An aminoglycan consisting of β-(1→4)-linked N-acetyl-D-glucosamine residues." []
subset: 3:STAR
synonym: "(1->4)-2-acetamido-2-deoxy-beta-D-glucan" EXACT IUPAC:NAME [IUPAC]
synonym: "(1->4)-2-acetamido-2-deoxy-beta-D-glucan" RELATED IUPAC:NAME [iupac]
synonym: "[1,4-(N-Acetyl-beta-D-glucosaminyl)]n" RELATED [kegg.compound]
synonym: "[4)-beta-D-GlcpNAc(1->]n" RELATED [iupac]
synonym: "beta-1,4-Poly-N-acetyl-D-glucosamine" RELATED [kegg.compound]
synonym: "Chitin" RELATED [kegg.compound]
synonym: "chitin" RELATED [iupac, uniprot_ft]
xref: cas:1398-61-4 {source="cas"}
xref: kegg.compound:C00461 {source="kegg.compound"}
xref: kegg.glycan:G10483 {source="kegg.glycan"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:21638 ! N-acylglucosamine
is_a: CHEBI:22506 ! aminoglycan
relationship: RO:0000087 CHEBI:73336 ! has role vulnerary
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
[Term]
id: CHEBI:17087
name: ketone
alt_id: CHEBI:13427
alt_id: CHEBI:13646
alt_id: CHEBI:24974
alt_id: CHEBI:6127
alt_id: CHEBI:8742
def: "A compound in which a carbonyl group is bonded to two carbon atoms: R2C=O (neither R may be H)." []
subset: 3:STAR
synonym: "a ketone" RELATED [uniprot_ft]
synonym: "cetone" RELATED [chebi]
synonym: "Keton" RELATED [chebi]
synonym: "Ketone" RELATED [kegg.compound]
synonym: "ketones" EXACT IUPAC:NAME [ChEBI, IUPAC]
synonym: "ketones" RELATED IUPAC:NAME [chebi, iupac]
synonym: "R-CO-R'" RELATED [kegg.compound]
xref: kegg.compound:C01450 {source="kegg.compound"}
xref: wikipedia.en:Ketone {source="wikipedia.en"}
is_a: CHEBI:36586 ! carbonyl compound
[Term]
id: CHEBI:17089
name: glycoprotein
alt_id: CHEBI:14349
alt_id: CHEBI:5481
alt_id: CHEBI:5493
def: "A compound in which a carbohydrate component is covalently bound to a protein component." []
subset: 3:STAR
synonym: "a glycoprotein" RELATED [uniprot_ft]
synonym: "glicoproteina" RELATED [chebi]
synonym: "glicoproteinas" RELATED [chebi]
synonym: "Glycoprotein" RELATED [kegg.compound]
synonym: "glycoproteine" RELATED [chebi]
synonym: "glycoproteines" RELATED [chebi]
synonym: "glycoproteins" EXACT IUPAC:NAME [IUPAC]
synonym: "glycoproteins" RELATED IUPAC:NAME [iupac]
synonym: "Glykoprotein" RELATED [chebi]
synonym: "Glykoproteine" RELATED [chebi]
xref: kegg.compound:C00326 {source="kegg.compound"}
is_a: CHEBI:33837 ! conjugated protein
is_a: CHEBI:63299 ! carbohydrate derivative
[Term]
id: CHEBI:17234
name: glucose
alt_id: CHEBI:14313
alt_id: CHEBI:24277
alt_id: CHEBI:33929
alt_id: CHEBI:5418
def: "An aldohexose used as a source of energy and metabolic intermediate." []
subset: 3:STAR
synonym: "DL-glucose" RELATED [chebi]
synonym: "Glc" RELATED [jcbn]
synonym: "gluco-hexose" EXACT IUPAC:NAME [IUPAC]
synonym: "gluco-hexose" RELATED IUPAC:NAME [iupac]
synonym: "Glucose" EXACT [KEGG_COMPOUND]
synonym: "Glucose" RELATED [kegg.compound]
synonym: "glucose" EXACT IUPAC:NAME [IUPAC]
synonym: "glucose" RELATED IUPAC:NAME [iupac]
synonym: "Glukose" RELATED [chebi]
xref: cas:50-99-7 {source="cas"}
xref: kegg.compound:C00293 {source="kegg.compound"}
xref: wikipedia.en:Glucose {source="wikipedia.en"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:33917 ! aldohexose
relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
[Term]
id: CHEBI:17258
name: 7H-purine
alt_id: CHEBI:14968
alt_id: CHEBI:8639
def: "The 7H-tautomer of purine." []
subset: 3:STAR
synonym: "7H-purine" EXACT IUPAC:NAME [IUPAC]
synonym: "7H-purine" RELATED IUPAC:NAME [iupac]
synonym: "Purine" EXACT [KEGG_COMPOUND]
synonym: "Purine" RELATED [kegg.compound]
synonym: "Purine base" RELATED [kegg.compound]
xref: gmelin:601779 {source="gmelin"}
xref: hmdb:HMDB0001366 {source="hmdb"}
xref: kegg.compound:C15587 {source="kegg.compound"}
xref: reaxys:3200 {source="reaxys"}
is_a: CHEBI:35584 ! purine
relationship: RO:0018036 CHEBI:35586 ! is tautomer of 1H-purine
relationship: RO:0018036 CHEBI:35588 ! is tautomer of 3H-purine
relationship: RO:0018036 CHEBI:35589 ! is tautomer of 9H-purine
[Term]
id: CHEBI:17272
name: propionate
alt_id: CHEBI:14903
alt_id: CHEBI:26290
def: "The conjugate base of propionic acid; a key precursor in lipid biosynthesis." []
subset: 3:STAR
synonym: "carboxylatoethane" RELATED [chebi]
synonym: "CH3-CH2-COO(-)" RELATED [iupac]
synonym: "EtCO2 anion" RELATED [nist]
synonym: "ethanecarboxylate" RELATED [chebi]
synonym: "ethylformate" RELATED [chebi]
synonym: "metacetonate" RELATED [chebi]
synonym: "methylacetate" RELATED [chebi]
synonym: "propanate" RELATED [chebi]
synonym: "propanoate" EXACT IUPAC:NAME [IUPAC]
synonym: "propanoate" RELATED IUPAC:NAME [iupac, uniprot_ft]
synonym: "propanoic acid, ion(1-)" RELATED [chemidplus]
synonym: "propionate" RELATED [iupac]
synonym: "pseudoacetate" RELATED [chebi]
xref: beilstein:3587503 {source="beilstein"}
xref: cas:72-03-7 {source="cas"}
xref: gmelin:1820 {source="gmelin"}
xref: kegg.compound:C00163 {source="kegg.compound"}
xref: pubmed:17951291 {source="pubmed"}
xref: pubmed:18375549 {source="pubmed"}
xref: pubmed:2647392 {source="pubmed"}
xref: umbbd.compound:c0277 {source="umbbd.compound"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:78113 ! fatty acid anion 3:0
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018033 CHEBI:30768 ! is deprotonated form of propionic acid
[Term]
id: CHEBI:17295
name: L-phenylalanine
alt_id: CHEBI:13151
alt_id: CHEBI:21370
alt_id: CHEBI:44851
alt_id: CHEBI:44885
alt_id: CHEBI:45079
alt_id: CHEBI:6282
def: "The L-enantiomer of phenylalanine." []
subset: 3:STAR
synonym: "(2S)-2-amino-3-phenylpropanoic acid" EXACT IUPAC:NAME [IUPAC]
synonym: "(2S)-2-amino-3-phenylpropanoic acid" RELATED IUPAC:NAME [iupac]
synonym: "(S)-2-Amino-3-phenylpropionic acid" RELATED [hmdb]
synonym: "(S)-alpha-Amino-beta-phenylpropionic acid" RELATED [kegg.compound]
synonym: "3-phenyl-L-alanine" RELATED [nist]
synonym: "beta-phenyl-L-alanine" RELATED [nist]
synonym: "F" RELATED [chebi]
synonym: "L-Phenylalanine" EXACT [KEGG_COMPOUND]
synonym: "L-Phenylalanine" RELATED [kegg.compound]
synonym: "L-phenylalanine" EXACT IUPAC:NAME [IUPAC]
synonym: "L-phenylalanine" RELATED IUPAC:NAME [iupac]
synonym: "Phe" RELATED [chebi]
synonym: "PHENYLALANINE" RELATED [pdb-ccd]
xref: cas:63-91-2 {source="cas"}
xref: drugbank:DB00120 {source="drugbank"}
xref: drugcentral:2144 {source="drugcentral"}
xref: ecmdb:ECMDB00159 {source="ecmdb"}
xref: gmelin:50837 {source="gmelin"}
xref: hmdb:HMDB0000159 {source="hmdb"}
xref: kegg.compound:C00079 {source="kegg.compound"}
xref: kegg.drug:D00021 {source="kegg.drug"}
xref: knapsack:C00001386 {source="knapsack"}
xref: metacyc.compound:PHE {source="metacyc.compound"}
xref: pdb-ccd:PHE {source="pdb-ccd"}
xref: pubmed:13945318 {source="pubmed"}
xref: pubmed:16893175 {source="pubmed"}
xref: pubmed:17784858 {source="pubmed"}
xref: pubmed:21203787 {source="pubmed"}
xref: pubmed:21956539 {source="pubmed"}
xref: pubmed:22081386 {source="pubmed"}
xref: pubmed:22112574 {source="pubmed"}
xref: pubmed:22143120 {source="pubmed"}
xref: pubmed:22209218 {source="pubmed"}
xref: pubmed:22494897 {source="pubmed"}
xref: pubmed:23836015 {source="pubmed"}
xref: pubmed:24464217 {source="pubmed"}
xref: pubmed:24733517 {source="pubmed"}
xref: pubmed:24966042 {source="pubmed"}
xref: reaxys:1910408 {source="reaxys"}
xref: wikipedia.en:Phenylalanine {source="wikipedia.en"}
xref: ymdb:YMDB00304 {source="ymdb"}
is_a: CHEBI:28044 ! phenylalanine
is_a: CHEBI:73690 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid
relationship: RO:0000087 CHEBI:27027 ! has role micronutrient
relationship: RO:0000087 CHEBI:50733 ! has role nutraceutical
relationship: RO:0000087 CHEBI:63332 ! has role EC 3.1.3.1 (alkaline phosphatase) inhibitor
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
relationship: RO:0000087 CHEBI:76967 ! has role human xenobiotic metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:84735 ! has role algal metabolite
relationship: RO:0018033 CHEBI:32487 ! is deprotonated form of L-phenylalaninium
relationship: RO:0018034 CHEBI:32486 ! is protonated form of L-phenylalaninate
relationship: RO:0018036 CHEBI:58095 ! is tautomer of L-phenylalanine zwitterion
relationship: RO:0018039 CHEBI:16998 ! is enantiomer of D-phenylalanine
[Term]
id: CHEBI:173084
name: ferroptosis inhibitor
def: "Any substance that inhibits the process of ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms." []
subset: 3:STAR
synonym: "ferroptosis inhibitors" RELATED [chebi]
xref: pubmed:32015325 {source="pubmed"}
xref: pubmed:32256352 {source="pubmed"}
xref: pubmed:32413317 {source="pubmed"}
xref: pubmed:33495651 {source="pubmed"}
xref: wikipedia.en:Ferroptosis {source="wikipedia.en"}
is_a: CHEBI:35222 ! inhibitor
is_a: CHEBI:52206 ! biochemical role
[Term]
id: CHEBI:173085
name: ferroptosis inducer
def: "Any substance that induces or promotes ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms." []
subset: 3:STAR
synonym: "ferroptosis inducers" RELATED [chebi]
xref: pubmed:31899616 {source="pubmed"}
xref: pubmed:32015325 {source="pubmed"}
xref: pubmed:33167414 {source="pubmed"}
xref: pubmed:34012798 {source="pubmed"}
xref: wikipedia.en:Ferroptosis {source="wikipedia.en"}
is_a: CHEBI:52206 ! biochemical role
[Term]
id: CHEBI:17326
name: nucleoside 5'-triphoshate
alt_id: CHEBI:13411
alt_id: CHEBI:14677
alt_id: CHEBI:17035
alt_id: CHEBI:25610
alt_id: CHEBI:7442
alt_id: CHEBI:7655
subset: 3:STAR
synonym: "NTP" RELATED [kegg.compound]
synonym: "Nucleoside triphosphate" RELATED [kegg.compound]
synonym: "nucleoside triphosphates" RELATED [chebi]
xref: kegg.compound:C00201 {source="kegg.compound"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:25608 ! nucleoside phosphate
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0018034 CHEBI:58104 ! is protonated form of nucleoside 5'-triphoshate(3-)
[Term]
id: CHEBI:17347
name: testosterone
alt_id: CHEBI:15214
alt_id: CHEBI:26883
alt_id: CHEBI:45798
alt_id: CHEBI:9461
def: "An androstanoid having 17β-hydroxy and 3-oxo groups, together with unsaturation at C-4‒C-5.." []
subset: 3:STAR
synonym: "17beta-Hydroxy-4-androsten-3-one" RELATED [kegg.compound]
synonym: "17beta-hydroxy-4-androsten-3-one" RELATED [chebi]
synonym: "17beta-hydroxyandrost-4-en-3-one" EXACT IUPAC:NAME [IUPAC]
synonym: "17beta-hydroxyandrost-4-en-3-one" RELATED IUPAC:NAME [iupac]
synonym: "4-androsten-17beta-ol-3-one" RELATED [nist]
synonym: "Androderm" RELATED [chemidplus]
synonym: "Testosteron" RELATED [chemidplus]
synonym: "testosterona" RELATED http://purl.obolibrary.org/obo/chebi/INN [chemidplus]
synonym: "TESTOSTERONE" RELATED [pdb-ccd]
synonym: "Testosterone" RELATED [kegg.compound]
synonym: "testosterone" RELATED http://purl.obolibrary.org/obo/chebi/INN [chemidplus, uniprot_ft]
synonym: "testosteronum" RELATED http://purl.obolibrary.org/obo/chebi/INN [chemidplus]
xref: beilstein:3653705 {source="beilstein"}
xref: cas:58-22-0 {source="cas"}
xref: drugbank:DB00624 {source="drugbank"}
xref: drugcentral:2607 {source="drugcentral"}
xref: gmelin:538843 {source="gmelin"}
xref: hmdb:HMDB0000234 {source="hmdb"}
xref: kegg.compound:C00535 {source="kegg.compound"}
xref: kegg.drug:D00075 {source="kegg.drug"}
xref: knapsack:C00003675 {source="knapsack"}
xref: lipidmaps:LMST02020002 {source="lipidmaps"}
xref: pdb-ccd:TES {source="pdb-ccd"}
xref: pubmed:10438974 {source="pubmed"}
xref: pubmed:11786693 {source="pubmed"}
xref: pubmed:18900503 {source="pubmed"}
xref: pubmed:24498482 {source="pubmed"}
xref: reaxys:1915399 {source="reaxys"}
xref: wikipedia.en:Testosterone {source="wikipedia.en"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:131621 ! C19-steroid
is_a: CHEBI:35343 ! 17beta-hydroxy steroid
is_a: CHEBI:47909 ! 3-oxo-Delta(4) steroid
is_a: CHEBI:50402 ! androstanoid
relationship: RO:0000087 CHEBI:50113 ! has role androgen
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0000087 CHEBI:83056 ! has role Daphnia magna metabolite
[Term]
id: CHEBI:17478
name: aldehyde
alt_id: CHEBI:13432
alt_id: CHEBI:13753
alt_id: CHEBI:13805
alt_id: CHEBI:13806
alt_id: CHEBI:17496
alt_id: CHEBI:22291
alt_id: CHEBI:2554
alt_id: CHEBI:8750
def: "A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group." []
subset: 3:STAR
synonym: "aldehido" RELATED [chebi]
synonym: "aldehidos" RELATED [chebi]
synonym: "Aldehyd" RELATED [chebi]
synonym: "Aldehyde" EXACT [KEGG_COMPOUND]
synonym: "Aldehyde" RELATED [kegg.compound]
synonym: "aldehyde" EXACT IUPAC:NAME [IUPAC]
synonym: "aldehyde" RELATED IUPAC:NAME [chebi, iupac]
synonym: "aldehydes" EXACT IUPAC:NAME [IUPAC]
synonym: "aldehydes" RELATED IUPAC:NAME [chebi, iupac]
synonym: "aldehydum" RELATED [chebi]
synonym: "an aldehyde" RELATED [uniprot_ft]
synonym: "RC(=O)H" RELATED [iupac]
synonym: "RCHO" RELATED [kegg.compound]
xref: kegg.compound:C00071 {source="kegg.compound"}
is_a: CHEBI:36586 ! carbonyl compound
relationship: has_part CHEBI:42485 ! formyl group
[Term]
id: CHEBI:17544
name: hydrogencarbonate
alt_id: CHEBI:13363
alt_id: CHEBI:22863
alt_id: CHEBI:40961
alt_id: CHEBI:5589
def: "The carbon oxoanion resulting from the removal of a proton from carbonic acid." []
subset: 3:STAR
synonym: "[CO2(OH)](-)" RELATED [iupac]
synonym: "Acid carbonate" RELATED [kegg.compound]
synonym: "Bicarbonate" RELATED [kegg.compound]
synonym: "BICARBONATE ION" RELATED [pdb-ccd]
synonym: "HCO3(-)" RELATED [iupac]
synonym: "HCO3-" RELATED [kegg.compound]
synonym: "hydrogen carbonate" RELATED [pdb-ccd]
synonym: "hydrogen(trioxidocarbonate)(1-)" EXACT IUPAC:NAME [IUPAC]
synonym: "hydrogen(trioxidocarbonate)(1-)" RELATED IUPAC:NAME [iupac]
synonym: "Hydrogencarbonate" EXACT [KEGG_COMPOUND]
synonym: "Hydrogencarbonate" RELATED [kegg.compound]
synonym: "hydrogencarbonate" EXACT IUPAC:NAME [IUPAC]
synonym: "hydrogencarbonate" RELATED IUPAC:NAME [iupac, uniprot_ft]
synonym: "hydrogencarbonate(1-)" EXACT IUPAC:NAME [IUPAC]
synonym: "hydrogencarbonate(1-)" RELATED IUPAC:NAME [iupac]
synonym: "hydrogentrioxocarbonate(1-)" EXACT IUPAC:NAME [IUPAC]
synonym: "hydrogentrioxocarbonate(1-)" RELATED IUPAC:NAME [iupac]
synonym: "hydrogentrioxocarbonate(IV)" EXACT IUPAC:NAME [IUPAC]
synonym: "hydrogentrioxocarbonate(IV)" RELATED IUPAC:NAME [iupac]
synonym: "hydroxidodioxidocarbonate(1-)" EXACT IUPAC:NAME [IUPAC]
synonym: "hydroxidodioxidocarbonate(1-)" RELATED IUPAC:NAME [iupac]
xref: beilstein:3903504 {source="beilstein"}
xref: cas:71-52-3 {source="cas"}
xref: gmelin:49249 {source="gmelin"}
xref: hmdb:HMDB0000595 {source="hmdb"}
xref: kegg.compound:C00288 {source="kegg.compound"}
xref: metacyc.compound:HCO3 {source="metacyc.compound"}
xref: pdb-ccd:BCT {source="pdb-ccd"}
xref: pubmed:17215880 {source="pubmed"}
xref: pubmed:17505962 {source="pubmed"}
xref: pubmed:18439416 {source="pubmed"}
xref: pubmed:28732801 {source="pubmed"}
xref: pubmed:29150416 {source="pubmed"}
xref: pubmed:29460248 {source="pubmed"}
xref: pubmed:29466234 {source="pubmed"}
xref: pubmed:4208463 {source="pubmed"}
xref: wikipedia.en:Bicarbonate {source="wikipedia.en"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:35604 ! carbon oxoanion
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018033 CHEBI:28976 ! is deprotonated form of carbonic acid
relationship: RO:0018034 CHEBI:41609 ! is protonated form of carbonate
[Term]
id: CHEBI:17578
name: toluene
alt_id: CHEBI:15248
alt_id: CHEBI:27022
alt_id: CHEBI:44023
alt_id: CHEBI:9624
def: "The simplest member of the class toluenes consisting of a benzene core which bears a single methyl substituent." []
subset: 3:STAR
synonym: "methylbenzene" RELATED [pdb-ccd]
synonym: "phenylmethane" RELATED [chemidplus]
synonym: "Toluen" RELATED [nist]
synonym: "TOLUENE" EXACT [PDBeChem]
synonym: "TOLUENE" RELATED [pdb-ccd]
synonym: "Toluene" EXACT [KEGG_COMPOUND]
synonym: "Toluene" RELATED [kegg.compound]
synonym: "toluene" EXACT IUPAC:NAME [IUPAC]
synonym: "toluene" RELATED IUPAC:NAME [chebi, iupac, uniprot_ft]
synonym: "Toluol" RELATED [nist]
xref: cas:108-88-3 {source="cas"}
xref: drugbank:DB01900 {source="drugbank"}
xref: gmelin:2456 {source="gmelin"}
xref: kegg.compound:C01455 {source="kegg.compound"}
xref: pdb-ccd:MBN {source="pdb-ccd"}
xref: pubmed:11182169 {source="pubmed"}
xref: pubmed:11314682 {source="pubmed"}
xref: pubmed:11846266 {source="pubmed"}
xref: pubmed:11991009 {source="pubmed"}
xref: pubmed:12062755 {source="pubmed"}
xref: pubmed:12213539 {source="pubmed"}
xref: pubmed:12237258 {source="pubmed"}
xref: pubmed:12784113 {source="pubmed"}
xref: pubmed:12876426 {source="pubmed"}
xref: pubmed:14512097 {source="pubmed"}
xref: pubmed:14559343 {source="pubmed"}
xref: pubmed:14605898 {source="pubmed"}
xref: pubmed:15015825 {source="pubmed"}
xref: pubmed:15019953 {source="pubmed"}
xref: pubmed:15119846 {source="pubmed"}
xref: pubmed:15193425 {source="pubmed"}
xref: pubmed:15542760 {source="pubmed"}
xref: pubmed:15567510 {source="pubmed"}
xref: pubmed:15695158 {source="pubmed"}
xref: pubmed:15796064 {source="pubmed"}
xref: pubmed:16316648 {source="pubmed"}
xref: pubmed:16348226 {source="pubmed"}
xref: pubmed:16601996 {source="pubmed"}
xref: pubmed:17145141 {source="pubmed"}
xref: pubmed:17175136 {source="pubmed"}
xref: pubmed:17497535 {source="pubmed"}
xref: pubmed:17725881 {source="pubmed"}
xref: pubmed:18397809 {source="pubmed"}
xref: pubmed:18832024 {source="pubmed"}
xref: pubmed:19261054 {source="pubmed"}
xref: pubmed:19384711 {source="pubmed"}
xref: pubmed:19429395 {source="pubmed"}
xref: pubmed:19635754 {source="pubmed"}
xref: pubmed:19765629 {source="pubmed"}
xref: pubmed:19825861 {source="pubmed"}
xref: pubmed:19928203 {source="pubmed"}
xref: pubmed:19969016 {source="pubmed"}
xref: pubmed:20347282 {source="pubmed"}
xref: pubmed:20837561 {source="pubmed"}
xref: pubmed:21430649 {source="pubmed"}
xref: pubmed:21655021 {source="pubmed"}
xref: pubmed:21731073 {source="pubmed"}
xref: pubmed:21802510 {source="pubmed"}
xref: pubmed:21840036 {source="pubmed"}
xref: reaxys:635760 {source="reaxys"}
xref: umbbd.compound:c0114 {source="umbbd.compound"}
xref: wikipedia.en:Toluene {source="wikipedia.en"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:134179 ! volatile organic compound
is_a: CHEBI:27024 ! toluenes
is_a: CHEBI:38975 ! methylbenzene
relationship: RO:0000087 CHEBI:48355 ! has role non-polar solvent
relationship: RO:0000087 CHEBI:48873 ! has role cholinergic antagonist
relationship: RO:0000087 CHEBI:50910 ! has role neurotoxin
relationship: RO:0000087 CHEBI:62803 ! has role fuel additive
[Term]
id: CHEBI:17579
name: beta-carotene
alt_id: CHEBI:10355
alt_id: CHEBI:12392
alt_id: CHEBI:22834
alt_id: CHEBI:40987
def: "A cyclic carotene obtained by dimerisation of all-trans-retinol. A strongly-coloured red-orange pigment abundant in plants and fruit and the most active and important provitamin A carotenoid." []
subset: 3:STAR
synonym: "1,1'-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaene-1,18-diyl]bis(2,6,6-trimethylcyclohexene)" RELATED [chebi]
synonym: "all-trans-beta-carotene" RELATED [nist, uniprot_ft]
synonym: "beta,beta-carotene" EXACT IUPAC:NAME [IUPAC]
synonym: "beta,beta-carotene" RELATED IUPAC:NAME [iupac]
synonym: "BETA-CAROTENE" RELATED [pdb-ccd]
synonym: "beta-Carotene" RELATED [kegg.compound]
synonym: "beta-Karotin" RELATED [chebi]
xref: cas:7235-40-7 {source="cas"}
xref: drugcentral:345 {source="drugcentral"}
xref: hmdb:HMDB0000561 {source="hmdb"}
xref: kegg.compound:C02094 {source="kegg.compound"}
xref: kegg.drug:D03101 {source="kegg.drug"}
xref: knapsack:C00000919 {source="knapsack"}
xref: lipidmaps:LMPR01070000 {source="lipidmaps"}
xref: lipidmaps:LMPR01070001 {source="lipidmaps"}
xref: metacyc.compound:CPD1F-129 {source="metacyc.compound"}
xref: pdb-ccd:BCR {source="pdb-ccd"}
xref: pubmed:11171227 {source="pubmed"}
xref: pubmed:11182771 {source="pubmed"}
xref: pubmed:11332447 {source="pubmed"}
xref: pubmed:11359610 {source="pubmed"}
xref: pubmed:11382814 {source="pubmed"}
xref: pubmed:11567548 {source="pubmed"}
xref: pubmed:11677037 {source="pubmed"}
xref: pubmed:11714348 {source="pubmed"}
xref: pubmed:11962062 {source="pubmed"}
xref: pubmed:12081834 {source="pubmed"}
xref: pubmed:12891827 {source="pubmed"}
xref: pubmed:14658721 {source="pubmed"}
xref: pubmed:14764912 {source="pubmed"}
xref: pubmed:14976384 {source="pubmed"}
xref: pubmed:14997360 {source="pubmed"}
xref: pubmed:15113067 {source="pubmed"}
xref: pubmed:15333155 {source="pubmed"}
xref: pubmed:15695449 {source="pubmed"}
xref: pubmed:15789045 {source="pubmed"}
xref: pubmed:15909543 {source="pubmed"}
xref: pubmed:15949680 {source="pubmed"}
xref: pubmed:15949683 {source="pubmed"}
xref: pubmed:16036331 {source="pubmed"}
xref: pubmed:16087476 {source="pubmed"}
xref: pubmed:16338959 {source="pubmed"}
xref: pubmed:16563447 {source="pubmed"}
xref: pubmed:17004738 {source="pubmed"}
xref: pubmed:17625873 {source="pubmed"}
xref: pubmed:17708644 {source="pubmed"}
xref: pubmed:17851775 {source="pubmed"}
xref: pubmed:18429004 {source="pubmed"}
xref: pubmed:18766464 {source="pubmed"}
xref: pubmed:18767554 {source="pubmed"}
xref: pubmed:18794175 {source="pubmed"}
xref: pubmed:19480350 {source="pubmed"}
xref: pubmed:19574250 {source="pubmed"}
xref: pubmed:19669835 {source="pubmed"}
xref: pubmed:19703237 {source="pubmed"}
xref: pubmed:19852884 {source="pubmed"}
xref: pubmed:19888275 {source="pubmed"}
xref: pubmed:19896667 {source="pubmed"}
xref: pubmed:19937581 {source="pubmed"}
xref: pubmed:20074992 {source="pubmed"}
xref: pubmed:20515074 {source="pubmed"}
xref: pubmed:22079732 {source="pubmed"}
xref: pubmed:22309480 {source="pubmed"}
xref: pubmed:22428124 {source="pubmed"}
xref: pubmed:22489215 {source="pubmed"}
xref: pubmed:22534340 {source="pubmed"}
xref: pubmed:22575730 {source="pubmed"}
xref: reaxys:1917416 {source="reaxys"}
xref: wikipedia.en:Beta_Carotene {source="wikipedia.en"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:139120 ! carotenoid beta-end derivative
is_a: CHEBI:35163 ! cyclic carotene
relationship: RO:0000087 CHEBI:173084 ! has role ferroptosis inhibitor
relationship: RO:0000087 CHEBI:22586 ! has role antioxidant
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
relationship: RO:0000087 CHEBI:26130 ! has role biological pigment
relationship: RO:0000087 CHEBI:67200 ! has role provitamin A
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
[Term]
id: CHEBI:17608
name: D-aldohexose
alt_id: CHEBI:12990
alt_id: CHEBI:21038
def: "Any D-aldose having a chain of six carbon atoms in the molecule." []
subset: 3:STAR
synonym: "D-aldohexoses" RELATED [chebi]
is_a: CHEBI:33917 ! aldohexose
is_a: CHEBI:4194 ! D-hexose
[Term]
id: CHEBI:17634
name: D-glucose
alt_id: CHEBI:12965
alt_id: CHEBI:20999
def: "A glucose with D-configuration." []
subset: 3:STAR
synonym: "D(+)-glucose" RELATED [chemidplus]
synonym: "D-(+)-glucose" RELATED [nist]
synonym: "D-gluco-hexose" EXACT IUPAC:NAME [IUPAC]
synonym: "D-gluco-hexose" RELATED IUPAC:NAME [iupac]
synonym: "D-glucose" EXACT IUPAC:NAME [IUPAC]
synonym: "D-glucose" RELATED IUPAC:NAME [iupac]
synonym: "dextrose" RELATED [nist]
synonym: "grape sugar" RELATED [chemidplus]
synonym: "Traubenzucker" RELATED [chemidplus]
xref: cas:50-99-7 {source="cas"}
is_a: CHEBI:17234 ! glucose
is_a: CHEBI:17608 ! D-aldohexose
[Term]
id: CHEBI:176497
name: geroprotector
def: "Any compound that supports healthy aging, slows the biological aging process, or extends lifespan." []
subset: 3:STAR
synonym: "anti-aging agent" RELATED [chebi]
synonym: "anti-aging agents" RELATED [chebi]
synonym: "anti-aging drug" RELATED [chebi]
synonym: "anti-aging drugs" RELATED [chebi]
synonym: "geroprotective agent" RELATED [chebi]
synonym: "geroprotective agents" RELATED [chebi]
synonym: "geroprotectors" RELATED [chebi]
xref: pubmed:23372317 {source="pubmed"}
xref: pubmed:28580190 {source="pubmed"}
xref: pubmed:30885572 {source="pubmed"}
xref: pubmed:33144142 {source="pubmed"}
xref: pubmed:33973253 {source="pubmed"}
xref: pubmed:34606237 {source="pubmed"}
xref: wikipedia.en:Geroprotector {source="wikipedia.en"}
is_a: CHEBI:50267 ! protective agent
[Term]
id: CHEBI:17668
name: ribonucleoside diphosphat
alt_id: CHEBI:15046
alt_id: CHEBI:26557
alt_id: CHEBI:8845
subset: 3:STAR
synonym: "Ribonucleoside diphosphate" RELATED [kegg.compound]
synonym: "ribonucleoside diphosphates" RELATED [chebi]
xref: kegg.compound:C03723 {source="kegg.compound"}
is_a: CHEBI:16862 ! nucleoside 5'-diphosphate
[Term]
id: CHEBI:17761
name: ceramide
alt_id: CHEBI:12487
alt_id: CHEBI:13954
alt_id: CHEBI:23074
alt_id: CHEBI:7242
def: "Ceramides (N-acyl-sphingoid bases) are a major subclass of sphingoid base derivatives with an amide-linked fatty acid. The fatty acids are typically saturated or monounsaturated with chain lengths from 14 to 26 carbon atoms; the presence of a hydroxyl group on carbon 2 is fairly common. Ceramides are generally precursors of more complex sphingolipids. In the illustrated generalised structure, R1 = OH, OX (where X = acyl, glycosyl, phosphate, phosphonate, etc.), or H." []
subset: 3:STAR
synonym: "a ceramide" RELATED [uniprot_ft]
synonym: "Cer" RELATED [iubmb]
synonym: "Ceramide" RELATED [kegg.compound]
synonym: "ceramides" RELATED [chebi]
synonym: "N-acylated sphingoid" RELATED [iubmb]
xref: kegg.compound:C00195 {source="kegg.compound"}
xref: lipidmaps_class:LMSP02 {source="lipidmaps_class"}
xref: pubmed:7542630 {source="pubmed"}
xref: wikipedia.en:Ceramide {source="wikipedia.en"}
is_a: CHEBI:26739 ! sphingolipid
is_a: CHEBI:37622 ! carboxamide
[Term]
id: CHEBI:17843
name: transfer RNA
alt_id: CHEBI:10652
alt_id: CHEBI:15145
alt_id: CHEBI:15163
alt_id: CHEBI:15164
alt_id: CHEBI:15165
def: "A single-stranded RNA molecule containing about 70-90 nucleotides, folded by intrastrand base pairing into a characteristic secondary ('cloverleaf') structure that carries a specific amino acid and matches it to its corresponding codon on an mRNA during protein synthesis." []
subset: 3:STAR
synonym: "RNA, transfer" RELATED [chemidplus]
synonym: "transfer RNA" EXACT IUPAC:NAME [IUPAC, KEGG_COMPOUND]
synonym: "transfer RNA" RELATED IUPAC:NAME [iupac, kegg.compound]
synonym: "tRNA" RELATED [kegg.compound, uniprot_ft]
xref: cas:9014-25-9 {source="cas"}
xref: kegg.compound:C00066 {source="kegg.compound"}
is_a: CHEBI:33697 ! ribonucleic acid
[Term]
id: CHEBI:17891
name: donor
alt_id: CHEBI:14202
alt_id: CHEBI:4697
def: "A molecular entity that can transfer (\"donate\") an electron, a pair of electrons, an atom or a group to another molecular entity." []
subset: 3:STAR
synonym: "Donator" RELATED [chebi]
synonym: "donneur" RELATED [chebi]
synonym: "Donor" RELATED [kegg.compound]
xref: kegg.compound:C01351 {source="kegg.compound"}
is_a: CHEBI:51086 ! chemical role
[Term]
id: CHEBI:17895
name: L-tyrosine
alt_id: CHEBI:13181
alt_id: CHEBI:21411
alt_id: CHEBI:46070
alt_id: CHEBI:46161
alt_id: CHEBI:6313
def: "An optically active form of tyrosine having L-configuration." []
subset: 3:STAR
synonym: "(-)-alpha-amino-p-hydroxyhydrocinnamic acid" RELATED [nist]
synonym: "(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid" RELATED [iupac]
synonym: "(S)-(-)-Tyrosine" RELATED [hmdb]
synonym: "(S)-2-Amino-3-(p-hydroxyphenyl)propionic acid" RELATED [kegg.compound]
synonym: "(S)-3-(p-Hydroxyphenyl)alanine" RELATED [kegg.compound]
synonym: "(S)-alpha-amino-4-hydroxybenzenepropanoic acid" RELATED [nist]
synonym: "(S)-Tyrosine" RELATED [hmdb]
synonym: "4-hydroxy-L-phenylalanine" RELATED [nist]
synonym: "L-Tyrosin" RELATED [chebi]
synonym: "L-Tyrosine" EXACT [KEGG_COMPOUND]
synonym: "L-Tyrosine" RELATED [kegg.compound]
synonym: "L-tyrosine" EXACT IUPAC:NAME [IUPAC]
synonym: "L-tyrosine" RELATED IUPAC:NAME [iupac]
synonym: "Tyr" RELATED [chebi]
synonym: "TYROSINE" EXACT [PDBeChem]
synonym: "TYROSINE" RELATED [pdb-ccd]
synonym: "Tyrosine" RELATED [kegg.compound]
synonym: "Y" RELATED [chebi]
xref: cas:60-18-4 {source="cas"}
xref: drugbank:DB00135 {source="drugbank"}
xref: drugcentral:2786 {source="drugcentral"}
xref: ecmdb:ECMDB00158 {source="ecmdb"}
xref: gmelin:50929 {source="gmelin"}
xref: hmdb:HMDB0000158 {source="hmdb"}
xref: kegg.compound:C00082 {source="kegg.compound"}
xref: kegg.drug:D00022 {source="kegg.drug"}
xref: knapsack:C00001397 {source="knapsack"}
xref: metacyc.compound:TYR {source="metacyc.compound"}
xref: pdb-ccd:TYR {source="pdb-ccd"}
xref: pubmed:15171683 {source="pubmed"}
xref: pubmed:22360849 {source="pubmed"}
xref: pubmed:22402312 {source="pubmed"}
xref: reaxys:392441 {source="reaxys"}
xref: umbbd.compound:c0234 {source="umbbd.compound"}
xref: wikipedia.en:Tyrosine {source="wikipedia.en"}
xref: ymdb:YMDB00364 {source="ymdb"}
is_a: CHEBI:18186 ! tyrosine
is_a: CHEBI:73690 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid
relationship: RO:0000087 CHEBI:27027 ! has role micronutrient
relationship: RO:0000087 CHEBI:50733 ! has role nutraceutical
relationship: RO:0000087 CHEBI:64416 ! has role EC 1.3.1.43 (arogenate dehydrogenase) inhibitor
relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
relationship: RO:0018033 CHEBI:32762 ! is deprotonated form of L-tyrosinium
relationship: RO:0018034 CHEBI:32760 ! is protonated form of L-tyrosinate(1-)
relationship: RO:0018036 CHEBI:58315 ! is tautomer of L-tyrosine zwitterion
relationship: RO:0018038 CHEBI:46209 ! has functional parent L-tyrosinal
relationship: RO:0018039 CHEBI:28479 ! is enantiomer of D-tyrosine
[Term]
id: CHEBI:17968
name: butyrate
alt_id: CHEBI:13924
alt_id: CHEBI:22946
def: "A short-chain fatty acid anion that is the conjugate base of butyric acid, obtained by deprotonation of the carboxy group." []
subset: 3:STAR
synonym: "1-butanoate" RELATED [chebi]
synonym: "1-butyrate" RELATED [chebi]
synonym: "1-propanecarboxylate" RELATED [chebi]
synonym: "butanate" RELATED [chebi]
synonym: "butanoate" EXACT IUPAC:NAME [IUPAC]
synonym: "butanoate" RELATED IUPAC:NAME [chebi, iupac, uniprot_ft]
synonym: "butanoic acid, ion(1-)" RELATED [chemidplus]
synonym: "butyrate" RELATED [iupac]
synonym: "CH3-[CH2]2-COO(-)" RELATED [iupac]
synonym: "n-butanoate" RELATED [chebi]
synonym: "n-butyrate" RELATED [chemidplus]
synonym: "propanecarboxylate" RELATED [chebi]
synonym: "propylformate" RELATED [chebi]
xref: cas:461-55-2 {source="cas"}
xref: gmelin:324289 {source="gmelin"}
xref: kegg.compound:C00246 {source="kegg.compound"}
xref: metacyc.compound:BUTYRIC_ACID {source="metacyc.compound"}
xref: pubmed:17190852 {source="pubmed"}
xref: pubmed:7496326 {source="pubmed"}
xref: reaxys:3601060 {source="reaxys"}
xref: umbbd.compound:c0035 {source="umbbd.compound"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:78115 ! fatty acid anion 4:0
relationship: RO:0000087 CHEBI:25212 ! has role metabolite
relationship: RO:0000087 CHEBI:61115 ! has role EC 3.5.1.98 (histone deacetylase) inhibitor
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018033 CHEBI:30772 ! is deprotonated form of butyric acid
[Term]
id: CHEBI:17972
name: ribonucleoside triphosphate
alt_id: CHEBI:15047
alt_id: CHEBI:26559
alt_id: CHEBI:8846
subset: 3:STAR
synonym: "Ribonucleoside triphosphate" RELATED [kegg.compound]
synonym: "ribonucleoside triphosphates" RELATED [chebi]
xref: kegg.compound:C03802 {source="kegg.compound"}
is_a: CHEBI:17326 ! nucleoside 5'-triphoshate
[Term]
id: CHEBI:18059
name: lipid
alt_id: CHEBI:14517
alt_id: CHEBI:25054
alt_id: CHEBI:6486
def: "'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids." []
subset: 3:STAR
synonym: "Lipid" RELATED [kegg.compound]
synonym: "lipids" EXACT IUPAC:NAME [IUPAC]
synonym: "lipids" RELATED IUPAC:NAME [iupac]
xref: kegg.compound:C01356 {source="kegg.compound"}
is_a: CHEBI:50860 ! organic molecular entity
[Term]
id: CHEBI:18085
name: glycosaminoglycan
alt_id: CHEBI:14361
alt_id: CHEBI:24398
alt_id: CHEBI:5495
def: "Any polysaccharide containing a substantial proportion of aminomonosaccharide residues." []
subset: 3:STAR
synonym: "glicosaminoglicano" RELATED [iupac]
synonym: "Glycosaminoglycan" EXACT [KEGG_COMPOUND]
synonym: "Glycosaminoglycan" RELATED [kegg.compound]
synonym: "glycosaminoglycan" EXACT IUPAC:NAME [IUPAC]
synonym: "glycosaminoglycan" RELATED IUPAC:NAME [iupac]
synonym: "glycosaminoglycane" RELATED [iupac]
synonym: "glycosaminoglycans" RELATED [chebi]
synonym: "Glykosaminoglykan" RELATED [chebi]
xref: kegg.compound:C02545 {source="kegg.compound"}
xref: wikipedia.en:Glycosaminoglycan {source="wikipedia.en"}
is_a: CHEBI:22506 ! aminoglycan
[Term]
id: CHEBI:18133
name: hexose
alt_id: CHEBI:14399
alt_id: CHEBI:24590
alt_id: CHEBI:5709
def: "Any six-carbon monosaccharide which in its linear form contains either an aldehyde group at position 1 (aldohexose) or a ketone group at position 2 (ketohexose)." []
subset: 3:STAR
synonym: "Hexose" RELATED [kegg.compound]
synonym: "hexoses" RELATED [chebi]
xref: glygen:G70994MS {source="glygen"}
xref: glytoucan:G70994MS {source="glytoucan"}
xref: kegg.compound:C00738 {source="kegg.compound"}
is_a: CHEBI:35381 ! monosaccharide
[Term]
id: CHEBI:18154
name: polysaccharide
alt_id: CHEBI:14864
alt_id: CHEBI:26205
alt_id: CHEBI:8322
def: "A biomacromolecule consisting of large numbers of monosaccharide residues linked glycosidically. This term is commonly used only for those containing more than ten monosaccharide residues." []
subset: 3:STAR
synonym: "Glycan" RELATED [kegg.compound]
synonym: "Glycane" RELATED [chebi]
synonym: "glycans" RELATED [iupac]
synonym: "Glykan" RELATED [chebi]
synonym: "Glykane" RELATED [chebi]
synonym: "polisacarido" RELATED [chebi]
synonym: "polisacaridos" RELATED [iupac]
synonym: "Polysaccharide" RELATED [kegg.compound]
synonym: "polysaccharides" EXACT IUPAC:NAME [IUPAC]
synonym: "polysaccharides" RELATED IUPAC:NAME [iupac]
xref: kegg.compound:C00420 {source="kegg.compound"}
is_a: CHEBI:16646 ! carbohydrate
is_a: CHEBI:167559 ! glycan
is_a: CHEBI:33694 ! biomacromolecule
[Term]
id: CHEBI:18186
name: tyrosine
alt_id: CHEBI:15277
alt_id: CHEBI:27176
alt_id: CHEBI:9800
def: "An α-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring." []
subset: 3:STAR
synonym: "2-amino-3-(4-hydroxyphenyl)propanoic acid" RELATED [iupac]
synonym: "2-Amino-3-(p-hydroxyphenyl)propionic acid" RELATED [kegg.compound]
synonym: "3-(p-Hydroxyphenyl)alanine" RELATED [kegg.compound]
synonym: "tirosina" RELATED [chebi]
synonym: "Tyr" RELATED [chebi]
synonym: "Tyrosin" RELATED [chebi]
synonym: "Tyrosine" EXACT [KEGG_COMPOUND]
synonym: "Tyrosine" RELATED [kegg.compound]
synonym: "tyrosine" EXACT IUPAC:NAME [IUPAC]
synonym: "tyrosine" RELATED IUPAC:NAME [iupac]
synonym: "Y" RELATED [chebi]
xref: cas:55520-40-6 {source="cas"}
xref: cas:556-03-6 {source="cas"}
xref: gmelin:27744 {source="gmelin"}
xref: kegg.compound:C01536 {source="kegg.compound"}
xref: knapsack:C00001397 {source="knapsack"}
xref: pubmed:17190852 {source="pubmed"}
xref: reaxys:515881 {source="reaxys"}
is_a: CHEBI:26167 ! polar amino acid
is_a: CHEBI:33704 ! alpha-amino acid
is_a: CHEBI:33856 ! aromatic amino acid
relationship: has_part CHEBI:50336 ! 4-hydroxybenzyl group
relationship: RO:0000087 CHEBI:83056 ! has role Daphnia magna metabolite
relationship: RO:0018033 CHEBI:32786 ! is deprotonated form of tyrosinium
relationship: RO:0018034 CHEBI:32784 ! is protonated form of tyrosinate(1-)
relationship: RO:0018038 CHEBI:30768 ! has functional parent propionic acid
[Term]
id: CHEBI:18237
name: glutamic acid
alt_id: CHEBI:24314
alt_id: CHEBI:5431
def: "An α-amino acid that is glutaric acid bearing a single amino substituent at position 2." []
subset: 3:STAR
synonym: "2-Aminoglutaric acid" RELATED [kegg.compound]
synonym: "2-aminopentanedioic acid" EXACT IUPAC:NAME [IUPAC]
synonym: "2-aminopentanedioic acid" RELATED IUPAC:NAME [iupac]
synonym: "DL-Glutamic acid" RELATED [kegg.drug]
synonym: "DL-Glutaminic acid" RELATED [kegg.compound]
synonym: "E" RELATED [chebi]
synonym: "Glu" RELATED [chebi]
synonym: "Glutamate" RELATED [kegg.compound]
synonym: "Glutamic acid" RELATED [kegg.compound]
synonym: "glutamic acid" EXACT IUPAC:NAME [IUPAC]
synonym: "glutamic acid" RELATED IUPAC:NAME [iupac]
synonym: "Glutaminic acid" RELATED [kegg.compound]
synonym: "Glutaminsaeure" RELATED [chebi]
xref: cas:617-65-2 {source="cas"}
xref: gmelin:101971 {source="gmelin"}
xref: kegg.compound:C00302 {source="kegg.compound"}
xref: kegg.drug:D04341 {source="kegg.drug"}
xref: knapsack:C00001358 {source="knapsack"}
xref: knapsack:C00019577 {source="knapsack"}
xref: pubmed:15739367 {source="pubmed"}
xref: pubmed:17190852 {source="pubmed"}
xref: pubmed:24616376 {source="pubmed"}
xref: pubmed:24984001 {source="pubmed"}
xref: reaxys:1723799 {source="reaxys"}
xref: wikipedia.en:Glutamic_acid {source="wikipedia.en"}
is_a: CHEBI:26167 ! polar amino acid
is_a: CHEBI:33704 ! alpha-amino acid
relationship: has_part CHEBI:50329 ! 2-carboxyethyl group
relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
relationship: RO:0018034 CHEBI:14321 ! is protonated form of glutamate(1-)
[Term]
id: CHEBI:18243
name: dopamine
alt_id: CHEBI:11695
alt_id: CHEBI:11930
alt_id: CHEBI:14203
alt_id: CHEBI:1764
alt_id: CHEBI:23886
alt_id: CHEBI:43686
def: "Catechol in which the hydrogen at position 4 is substituted by a 2-aminoethyl group." []
subset: 3:STAR
synonym: "2-(3,4-Dihydroxyphenyl)ethylamine" RELATED [kegg.compound]
synonym: "2-(3,4-dihydroxyphenyl)ethylamine" RELATED [chebi]
synonym: "3,4-Dihydroxyphenethylamine" RELATED [kegg.compound]
synonym: "3-Hydroxytyramine" RELATED [chemidplus]
synonym: "4-(2-Aminoethyl)-1,2-benzenediol" RELATED [kegg.compound]
synonym: "4-(2-aminoethyl)-1,2-benzenediol" RELATED [chebi]
synonym: "4-(2-Aminoethyl)benzene-1,2-diol" EXACT [KEGG_COMPOUND]
synonym: "4-(2-Aminoethyl)benzene-1,2-diol" RELATED [kegg.compound]
synonym: "4-(2-aminoethyl)benzene-1,2-diol" EXACT IUPAC:NAME [IUPAC]
synonym: "4-(2-aminoethyl)benzene-1,2-diol" RELATED IUPAC:NAME [iupac]
synonym: "4-(2-aminoethyl)catechol" RELATED [chemidplus]
synonym: "4-(2-aminoethyl)pyrocatechol" RELATED [chemidplus]
synonym: "Deoxyepinephrine" RELATED [drugbank]
synonym: "dopamina" RELATED http://purl.obolibrary.org/obo/chebi/INN [chemidplus]
synonym: "Dopamine" RELATED [kegg.compound]
synonym: "dopamine" RELATED http://purl.obolibrary.org/obo/chebi/INN [chebi]
synonym: "dopaminum" RELATED http://purl.obolibrary.org/obo/chebi/INN [chemidplus]
synonym: "Hydroxytyramin" RELATED [drugbank]
xref: cas:51-61-6 {source="cas"}
xref: drugbank:DB00988 {source="drugbank"}
xref: drugcentral:947 {source="drugcentral"}
xref: hmdb:HMDB0000073 {source="hmdb"}
xref: kegg.compound:C03758 {source="kegg.compound"}
xref: kegg.drug:D07870 {source="kegg.drug"}
xref: knapsack:C00001408 {source="knapsack"}
xref: lincs.smallmolecule:LSM-4630 {source="lincs.smallmolecule"}
xref: metacyc.compound:DOPAMINE {source="metacyc.compound"}
xref: pubmed:10629745 {source="pubmed"}
xref: pubmed:11149432 {source="pubmed"}
xref: pubmed:9422813 {source="pubmed"}
xref: reaxys:1072822 {source="reaxys"}
xref: wikipedia.en:Dopamine {source="wikipedia.en"}
is_a: CHEBI:33567 ! catecholamine
relationship: RO:0000087 CHEBI:35522 ! has role beta-adrenergic agonist
relationship: RO:0000087 CHEBI:35524 ! has role sympathomimetic agent
relationship: RO:0000087 CHEBI:38147 ! has role cardiotonic drug
relationship: RO:0000087 CHEBI:48560 ! has role dopaminergic agent
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018033 CHEBI:59905 ! is deprotonated form of dopaminium(1+)
[Term]
id: CHEBI:18246
name: (1->4)-beta-D-glucan
alt_id: CHEBI:10812
alt_id: CHEBI:23063
alt_id: CHEBI:3529
def: "A β-D-glucan in which the glucose units are connected by (1→4) linkages." []
subset: 3:STAR
synonym: "(1,4-beta-D-glucosyl)(n)" RELATED [uniprot_ft]
synonym: "(1,4-beta-D-Glucosyl)n" RELATED [kegg.compound]
synonym: "(1,4-beta-D-glucosyl)n" RELATED [iubmb]
synonym: "(1,4-beta-D-Glucosyl)n+1" RELATED [kegg.compound]
synonym: "(1,4-beta-D-Glucosyl)n-1" RELATED [kegg.compound]
synonym: "(1->4)-beta-D-glucopyranan" EXACT IUPAC:NAME [IUPAC]
synonym: "(1->4)-beta-D-glucopyranan" RELATED IUPAC:NAME [iupac]
synonym: "1,4-beta-D-Glucan" RELATED [kegg.compound]
synonym: "Cellulose" RELATED [kegg.compound]
xref: cas:9004-34-6 {source="cas"}
xref: hmdb:HMDB0006944 {source="hmdb"}
xref: kegg.compound:C00760 {source="kegg.compound"}
xref: kegg.drug:D00093 {source="kegg.drug"}
xref: kegg.glycan:G10481 {source="kegg.glycan"}
is_a: CHEBI:28793 ! beta-D-glucan
[Term]
id: CHEBI:18248
name: iron atom
alt_id: CHEBI:13322
alt_id: CHEBI:24872
alt_id: CHEBI:5974
def: "An iron group element atom that has atomic number 26." []
subset: 3:STAR
synonym: "26Fe" RELATED [iupac]
synonym: "Eisen" RELATED [chebi]
synonym: "Fe" RELATED [iupac, uniprot_ft]
synonym: "fer" RELATED [chebi]
synonym: "ferrum" RELATED [iupac]
synonym: "hierro" RELATED [chebi]
synonym: "Iron" EXACT [KEGG_COMPOUND]
synonym: "Iron" RELATED [kegg.compound]
synonym: "iron" EXACT IUPAC:NAME [IUPAC]
synonym: "iron" RELATED IUPAC:NAME [chebi, iupac]
xref: cas:7439-89-6 {source="cas"}
xref: drugbank:DB01592 {source="drugbank"}
xref: hmdb:HMDB0015531 {source="hmdb"}
xref: kegg.compound:C00023 {source="kegg.compound"}
xref: reaxys:4122945 {source="reaxys"}
xref: webelements:Fe {source="webelements"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:33356 ! iron group element atom
relationship: RO:0000087 CHEBI:27027 ! has role micronutrient
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
[Term]
id: CHEBI:18254
name: ribonucleoside
alt_id: CHEBI:13014
alt_id: CHEBI:13015
alt_id: CHEBI:13685
alt_id: CHEBI:21085
alt_id: CHEBI:26560
alt_id: CHEBI:4240
alt_id: CHEBI:8844
def: "Any nucleoside where the sugar component is D-ribose." []
subset: 3:STAR
synonym: "a ribonucleoside" RELATED [uniprot_ft]
synonym: "Ribonucleoside" RELATED [kegg.compound]
synonym: "ribonucleosides" RELATED [chebi]
xref: kegg.compound:C00911 {source="kegg.compound"}
is_a: CHEBI:33838 ! nucleoside
is_a: CHEBI:47019 ! dihydroxytetrahydrofuran
[Term]
id: CHEBI:18282
name: nucleobase
alt_id: CHEBI:13873
alt_id: CHEBI:25598
alt_id: CHEBI:2995
def: "That part of DNA or RNA that may be involved in pairing." []
subset: 3:STAR
synonym: "Base" EXACT [KEGG_COMPOUND]
synonym: "Base" RELATED [kegg.compound]
synonym: "nucleobases" RELATED [chebi]
xref: kegg.compound:C00701 {source="kegg.compound"}
xref: wikipedia.en:Nucleobase {source="wikipedia.en"}
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound
[Term]
id: CHEBI:18295
name: histamine
alt_id: CHEBI:14401
alt_id: CHEBI:24596
alt_id: CHEBI:43187
alt_id: CHEBI:817
def: "A member of the class of imidazoles that is 1H-imidazole substituted at position C-4 by a 2-aminoethyl group." []
subset: 3:STAR
synonym: "1H-Imidazole-4-ethanamine" RELATED [kegg.compound]
synonym: "2-(1H-imidazol-4-yl)ethanamine" EXACT IUPAC:NAME [IUPAC]
synonym: "2-(1H-imidazol-4-yl)ethanamine" RELATED IUPAC:NAME [iupac]
synonym: "2-(4-Imidazolyl)ethylamine" RELATED [kegg.compound]
synonym: "HISTAMINE" RELATED [pdb-ccd]
synonym: "Histamine" RELATED [kegg.compound]
xref: cas:51-45-6 {source="cas"}
xref: drugcentral:1375 {source="drugcentral"}
xref: gmelin:2968 {source="gmelin"}
xref: hmdb:HMDB0000870 {source="hmdb"}
xref: kegg.compound:C00388 {source="kegg.compound"}
xref: kegg.drug:D08040 {source="kegg.drug"}
xref: knapsack:C00001414 {source="knapsack"}
xref: metacyc.compound:HISTAMINE {source="metacyc.compound"}
xref: pdb-ccd:HSM {source="pdb-ccd"}
xref: pubmed:16399866 {source="pubmed"}
xref: pubmed:19547708 {source="pubmed"}
xref: pubmed:19843401 {source="pubmed"}
xref: pubmed:22770225 {source="pubmed"}
xref: pubmed:24101735 {source="pubmed"}
xref: reaxys:2012 {source="reaxys"}
xref: wikipedia.en:Histamine {source="wikipedia.en"}
is_a: CHEBI:24780 ! imidazoles
is_a: CHEBI:64365 ! aralkylamino compound
relationship: RO:0000087 CHEBI:25512 ! has role neurotransmitter
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018033 CHEBI:58432 ! is deprotonated form of histaminium
[Term]
id: CHEBI:18310
name: alkane
alt_id: CHEBI:13435
alt_id: CHEBI:22317
alt_id: CHEBI:2576
def: "An acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2, and therefore consisting entirely of hydrogen atoms and saturated carbon atoms." []
subset: 3:STAR
synonym: "alcane" RELATED [iupac]
synonym: "alcanes" RELATED [iupac]
synonym: "alcano" RELATED [iupac]
synonym: "alcanos" RELATED [iupac]
synonym: "Alkan" RELATED [chebi]
synonym: "Alkane" EXACT [KEGG_COMPOUND]
synonym: "Alkane" RELATED [kegg.compound]
synonym: "alkane" EXACT IUPAC:NAME [IUPAC]
synonym: "alkane" RELATED IUPAC:NAME [iupac]
synonym: "alkanes" EXACT IUPAC:NAME [IUPAC]
synonym: "alkanes" RELATED IUPAC:NAME [iupac]
synonym: "an alkane" RELATED [uniprot_ft]
synonym: "RH" RELATED [kegg.compound]
xref: kegg.compound:C01371 {source="kegg.compound"}
is_a: CHEBI:24632 ! hydrocarbon
is_a: CHEBI:33653 ! aliphatic compound
[Term]
id: CHEBI:18357
name: (R)-noradrenaline
alt_id: CHEBI:1
alt_id: CHEBI:14668
alt_id: CHEBI:25592
alt_id: CHEBI:258884
alt_id: CHEBI:43725
def: "The R-enantiomer of noradrenaline." []
subset: 3:STAR
synonym: "(-)-arterenol" RELATED [chemidplus]
synonym: "(-)-noradrenaline" RELATED [iuphar]
synonym: "(-)-norepinephrine" RELATED [chemidplus]
synonym: "(R)-(-)-norepinephrine" RELATED [chemidplus]
synonym: "(R)-4-(2-amino-1-hydroxyethyl)-1,2-benzenediol" RELATED [chemidplus]
synonym: "(R)-norepinephrine" RELATED [chemidplus]
synonym: "4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol" RELATED [kegg.compound]
synonym: "4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol" EXACT IUPAC:NAME [IUPAC]
synonym: "4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol" RELATED IUPAC:NAME [iupac]
synonym: "Arterenol" RELATED [kegg.compound]
synonym: "L-Noradrenaline" RELATED [kegg.compound]
synonym: "L-NOREPINEPHRINE" RELATED [pdb-ccd]
synonym: "Noradrenaline" RELATED [kegg.compound]
synonym: "norepinefrina" RELATED http://purl.obolibrary.org/obo/chebi/INN [chebi]
synonym: "Norepinephrine" RELATED [kegg.compound]
synonym: "norepinephrine" RELATED http://purl.obolibrary.org/obo/chebi/INN [chemidplus, who_mednet]
synonym: "norepinephrinum" RELATED http://purl.obolibrary.org/obo/chebi/INN [chebi]
xref: beilstein:4231961 {source="beilstein"}
xref: cas:51-41-2 {source="cas"}
xref: drugbank:DB00368 {source="drugbank"}
xref: drugcentral:1960 {source="drugcentral"}
xref: hmdb:HMDB0000216 {source="hmdb"}
xref: kegg.compound:C00547 {source="kegg.compound"}
xref: kegg.drug:D00076 {source="kegg.drug"}
xref: knapsack:C00001424 {source="knapsack"}
xref: pdb-ccd:LNR {source="pdb-ccd"}
xref: reaxys:2804840 {source="reaxys"}
xref: wikipedia.en:Norepinephrine {source="wikipedia.en"}
is_a: CHEBI:33569 ! noradrenaline
relationship: RO:0000087 CHEBI:25512 ! has role neurotransmitter
relationship: RO:0000087 CHEBI:35524 ! has role sympathomimetic agent
relationship: RO:0000087 CHEBI:35569 ! has role alpha-adrenergic agonist
relationship: RO:0000087 CHEBI:50514 ! has role vasoconstrictor agent
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0018033 CHEBI:72587 ! is deprotonated form of (R)-noradrenaline(1+)
relationship: RO:0018039 CHEBI:33571 ! is enantiomer of (S)-noradrenaline
[Term]
id: CHEBI:18367
name: phosphate(3-)
alt_id: CHEBI:14791
alt_id: CHEBI:45024
alt_id: CHEBI:7793
def: "A phosphate ion that is the conjugate base of hydrogenphosphate." []
subset: 3:STAR
synonym: "[PO4](3-)" RELATED [iupac]
synonym: "Orthophosphate" RELATED [kegg.compound]
synonym: "Phosphate" EXACT [KEGG_COMPOUND]
synonym: "Phosphate" RELATED [kegg.compound]
synonym: "phosphate" EXACT IUPAC:NAME [IUPAC]
synonym: "phosphate" RELATED IUPAC:NAME [iupac]
synonym: "PHOSPHATE ION" RELATED [pdb-ccd]
synonym: "PO4(3-)" RELATED [iupac]
synonym: "tetraoxidophosphate(3-)" EXACT IUPAC:NAME [IUPAC]
synonym: "tetraoxidophosphate(3-)" RELATED IUPAC:NAME [iupac]
synonym: "tetraoxophosphate(3-)" EXACT IUPAC:NAME [IUPAC]
synonym: "tetraoxophosphate(3-)" RELATED IUPAC:NAME [iupac]
synonym: "tetraoxophosphate(V)" EXACT IUPAC:NAME [IUPAC]
synonym: "tetraoxophosphate(V)" RELATED IUPAC:NAME [iupac]
xref: cas:14265-44-2 {source="cas"}
xref: gmelin:1997 {source="gmelin"}
xref: kegg.compound:C00009 {source="kegg.compound"}
xref: pdb-ccd:PO4 {source="pdb-ccd"}
xref: reaxys:3903772 {source="reaxys"}
xref: wikipedia.en:Phosphate {source="wikipedia.en"}
is_a: CHEBI:35780 ! phosphate ion
is_a: CHEBI:79387 ! trivalent inorganic anion
relationship: RO:0018033 CHEBI:43474 ! is deprotonated form of hydrogenphosphate
[Term]
id: CHEBI:190295
name: inorganic calcium salt
def: "A calcium salt that lacks C-H bonds" []
subset: 2:STAR
xref: pubmed:28457049 {source="pubmed"}
is_a: CHEBI:167164 ! mineral nutrient
is_a: CHEBI:24839 ! inorganic salt
[Term]
id: CHEBI:194548
name: 4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
def: "A catecholamine in which the aminoethyl side-chain is hydroxy-substituted at C-1 and methylated on nitrogen." []
subset: 3:STAR
synonym: "4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol" EXACT IUPAC:NAME [IUPAC]
synonym: "4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:33567 ! catecholamine
[Term]
id: CHEBI:20664
name: 5beta-cholane
subset: 3:STAR
synonym: "5beta-cholane" EXACT IUPAC:NAME [IUPAC]
synonym: "5beta-cholane" RELATED IUPAC:NAME [iupac]
xref: beilstein:2048472 {source="beilstein"}
is_a: CHEBI:35519 ! cholane
[Term]
id: CHEBI:20706
name: 6-aminopurines
def: "Any compound having 6-aminopurine (adenine) as part of its structure." []
subset: 3:STAR
synonym: "6-aminopurines" RELATED [chebi]
xref: pubmed:1646334 {source="pubmed"}
xref: pubmed:18524423 {source="pubmed"}
xref: pubmed:7342604 {source="pubmed"}
is_a: CHEBI:22527 ! aminopurine
[Term]
id: CHEBI:21638
name: N-acylglucosamine
subset: 3:STAR
synonym: "N-acylglucosamine" RELATED [chebi]
synonym: "N-acylglucosamines" RELATED [chebi]
is_a: CHEBI:21656 ! N-acyl-hexosamine
is_a: CHEBI:24271 ! glucosamines
[Term]
id: CHEBI:21656
name: N-acyl-hexosamine
subset: 3:STAR
synonym: "N-acyl-hexosamine" RELATED [chebi]
synonym: "N-acyl-hexosamines" RELATED [chebi]
is_a: CHEBI:24586 ! hexosamine
[Term]
id: CHEBI:21731
name: N-glycosyl compound
def: "A glycosyl compound arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to a nitrogen atom, thus creating a C-N bond." []
subset: 3:STAR
synonym: "glycosylamine" EXACT IUPAC:NAME [IUPAC]
synonym: "glycosylamine" RELATED IUPAC:NAME [iupac]
synonym: "glycosylamines" RELATED [iupac]
synonym: "N-glycoside" RELATED [chebi]
synonym: "N-glycosides" RELATED [chebi]
synonym: "N-glycosyl compounds" RELATED [chebi]
is_a: CHEBI:35352 ! organonitrogen compound
is_a: CHEBI:63161 ! glycosyl compound
[Term]
id: CHEBI:21968
name: O-phosphoamino acid
subset: 3:STAR
synonym: "O-phosphoamino acids" RELATED [chebi]
is_a: CHEBI:25703 ! organic phosphate
is_a: CHEBI:26051 ! phosphoamino acid
is_a: CHEBI:37734 ! phosphoric ester
[Term]
id: CHEBI:22160
name: acetamides
def: "Compounds with the general formula RNHC(=O)CH3." []
subset: 3:STAR
is_a: CHEBI:37622 ! carboxamide
[Term]
id: CHEBI:22221
name: acyl group
def: "An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure RkE(=O)l(OH)m (l ≠ 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids." []
subset: 3:STAR
synonym: "acyl group" RELATED [iupac]
synonym: "acyl groups" RELATED [chebi]
synonym: "alkanoyl" EXACT IUPAC:NAME [IUPAC]
synonym: "alkanoyl" RELATED IUPAC:NAME [iupac]
synonym: "alkanoyl group" RELATED [chebi]
synonym: "groupe acyle" RELATED [iupac]
is_a: CHEBI:33247 ! organic group
[Term]
id: CHEBI:22256
name: adenosine phosphate
subset: 3:STAR
synonym: "adenosine phosphates" RELATED [chebi]
is_a: CHEBI:61296 ! adenyl ribonucleotide
relationship: RO:0018038 CHEBI:16335 ! has functional parent adenosine
[Term]
id: CHEBI:22260
name: adenosines
def: "Any purine ribonucleoside that is a derivative of adenosine." []
subset: 3:STAR
is_a: CHEBI:26399 ! purine ribonucleoside
relationship: RO:0018038 CHEBI:16708 ! has functional parent adenine
[Term]
id: CHEBI:22313
name: alkaline earth metal atom
subset: 3:STAR
synonym: "alkaline earth metal" RELATED [chebi]
synonym: "alkaline earth metals" EXACT IUPAC:NAME [IUPAC]
synonym: "alkaline earth metals" RELATED IUPAC:NAME [iupac]
synonym: "alkaline-earth metal" RELATED [chebi]
synonym: "alkaline-earth metals" RELATED [chebi]
synonym: "Erdalkalimetall" RELATED [chebi]
synonym: "Erdalkalimetalle" RELATED [chebi]
synonym: "metal alcalino-terreux" RELATED [chebi]
synonym: "metal alcalinoterreo" RELATED [chebi]
synonym: "metales alcalinoterreos" RELATED [chebi]
synonym: "metaux alcalino-terreux" RELATED [chebi]
is_a: CHEBI:33318 ! main group element atom
is_a: CHEBI:33521 ! metal atom
is_a: CHEBI:33559 ! s-block element atom
[Term]
id: CHEBI:22314
name: alkali metal atom
subset: 3:STAR
synonym: "alkali metal" RELATED [chebi]
synonym: "alkali metals" EXACT IUPAC:NAME [IUPAC]
synonym: "alkali metals" RELATED IUPAC:NAME [iupac]
synonym: "Alkalimetall" RELATED [chebi]
synonym: "Alkalimetalle" RELATED [chebi]
synonym: "metal alcalin" RELATED [chebi]
synonym: "metal alcalino" RELATED [chebi]
synonym: "metales alcalinos" RELATED [chebi]
synonym: "metaux alcalins" RELATED [chebi]
is_a: CHEBI:33318 ! main group element atom
is_a: CHEBI:33521 ! metal atom
is_a: CHEBI:33559 ! s-block element atom
[Term]
id: CHEBI:22315
name: alkaloid
def: "Any of the naturally occurring, basic nitrogen compounds (mostly heterocyclic) occurring mostly in the plant kingdom, but also found in bacteria, fungi, and animals. By extension, certain neutral compounds biogenetically related to basic alkaloids are also classed as alkaloids. Amino acids, peptides, proteins, nucleotides, nucleic acids, amino sugars and antibiotics are not normally regarded as alkaloids. Compounds in which the nitrogen is exocyclic (dopamine, mescaline, serotonin, etc.) are usually classed as amines rather than alkaloids." []
subset: 3:STAR
synonym: "alcaloide" RELATED [chebi]
synonym: "alcaloides" RELATED [chebi]
synonym: "Alkaloid" RELATED [chebi]
synonym: "Alkaloide" RELATED [chebi]
synonym: "alkaloids" EXACT IUPAC:NAME [IUPAC]
synonym: "alkaloids" RELATED IUPAC:NAME [iupac]
xref: wikipedia.en:Alkaloid {source="wikipedia.en"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:35352 ! organonitrogen compound
relationship: RO:0000087 CHEBI:25212 ! has role metabolite
[Term]
id: CHEBI:22492
name: amino aldehyde
def: "Any aldehyde which contains an amino group." []
subset: 3:STAR
xref: pubmed:17105264 {source="pubmed"}
is_a: CHEBI:17478 ! aldehyde
[Term]
id: CHEBI:22506
name: aminoglycan
subset: 3:STAR
synonym: "aminoglycans" RELATED [chebi]
is_a: CHEBI:35352 ! organonitrogen compound
is_a: CHEBI:65212 ! polysaccharide derivative
[Term]
id: CHEBI:22527
name: aminopurine
def: "Any purine having at least one amino substituent." []
subset: 3:STAR
synonym: "aminopurines" RELATED [chebi]
is_a: CHEBI:26401 ! purines
[Term]
id: CHEBI:22563
name: anion
def: "A monoatomic or polyatomic species having one or more elementary charges of the electron." []
subset: 3:STAR
synonym: "Anion" RELATED [chebi]
synonym: "anion" EXACT IUPAC:NAME [IUPAC]
synonym: "anion" RELATED IUPAC:NAME [chebi, iupac]
synonym: "Anionen" RELATED [chebi]
synonym: "aniones" RELATED [chebi]
synonym: "anions" RELATED [iupac]
is_a: CHEBI:24870 ! ion
[Term]
id: CHEBI:22586
name: antioxidant
def: "A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides." []
subset: 3:STAR
synonym: "antioxidants" RELATED [chebi]
synonym: "antioxydant" RELATED [chebi]
synonym: "antoxidant" RELATED [chebi]
is_a: CHEBI:51086 ! chemical role
[Term]
id: CHEBI:22695
name: base
def: "A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Brønsted base) or with the vacant orbital of some other molecular entity (Lewis base)." []
subset: 3:STAR
synonym: "Base" RELATED [chebi]
synonym: "base" EXACT IUPAC:NAME [IUPAC]
synonym: "base" RELATED IUPAC:NAME [chebi, iupac]
synonym: "Base1" RELATED [kegg.compound]
synonym: "Base2" RELATED [kegg.compound]
synonym: "Basen" RELATED [chebi]
synonym: "bases" RELATED [chebi]
synonym: "Nucleobase" RELATED [kegg.compound]
xref: kegg.compound:C00701 {source="kegg.compound"}
is_a: CHEBI:51086 ! chemical role
[Term]
id: CHEBI:22712
name: benzenes
def: "Any benzenoid aromatic compound consisting of the benzene skeleton and its substituted derivatives." []
subset: 3:STAR
is_a: CHEBI:33836 ! benzenoid aromatic compound
[Term]
id: CHEBI:22728
name: benzopyrrole
subset: 3:STAR
synonym: "benzopyrroles" RELATED [chebi]
is_a: CHEBI:27171 ! organic heterobicyclic compound
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound
is_a: CHEBI:38180 ! polycyclic heteroarene
[Term]
id: CHEBI:22744
name: benzyl group
subset: 3:STAR
synonym: "benzyl" EXACT IUPAC:NAME [IUPAC]
synonym: "benzyl" RELATED IUPAC:NAME [iupac]
synonym: "Bn" RELATED [chebi]
synonym: "C6H5-CH2-" RELATED [iupac]
synonym: "phenylalanine side-chain" RELATED [chebi]
synonym: "phenylmethyl" RELATED [iupac]
is_a: CHEBI:33452 ! benzylic group
is_a: CHEBI:50325 ! proteinogenic amino-acid side-chain group
relationship: RO:0018037 CHEBI:17578 ! is substitutent group from toluene
[Term]
id: CHEBI:228364
name: NMR chemical shift reference compound
def: "Any compound that produces a peak used as reference frequency in the δ chemical shift scale." []
subset: 3:STAR
synonym: "NMR chemical shift reference compounds" RELATED [chebi]
synonym: "NMR chemical shift standard" RELATED [chebi]
synonym: "NMR chemical shift standards" RELATED [chebi]
synonym: "NMR internal standard" RELATED [chebi]
synonym: "NMR internal standards" RELATED [chebi]
synonym: "NMR reference standard" RELATED [chebi]
synonym: "NMR reference standards" RELATED [chebi]
is_a: CHEBI:33232 ! application
is_a: CHEBI:51086 ! chemical role
[Term]
id: CHEBI:22868
name: bile salt
def: "A sodium salt of the conjugate of any bile acid with either glycine or taurine." []
subset: 3:STAR
synonym: "Bile acid" RELATED [kegg.compound]
synonym: "bile salts" RELATED [chebi]
xref: kegg.compound:C01558 {source="kegg.compound"}
is_a: CHEBI:36078 ! cholanoid
is_a: CHEBI:38700 ! organic sodium salt
[Term]
id: CHEBI:22984
name: calcium atom
subset: 3:STAR
synonym: "20Ca" RELATED [iupac]
synonym: "Ca" RELATED [iupac, uniprot_ft]
synonym: "calcio" RELATED [chebi]
synonym: "Calcium" RELATED [kegg.compound]
synonym: "calcium" EXACT IUPAC:NAME [IUPAC]
synonym: "calcium" RELATED IUPAC:NAME [chebi, iupac]
synonym: "Kalzium" RELATED [chebi]
xref: cas:7440-70-2 {source="cas"}
xref: drugbank:DB01373 {source="drugbank"}
xref: kegg.compound:C00076 {source="kegg.compound"}
xref: webelements:Ca {source="webelements"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:22313 ! alkaline earth metal atom
relationship: RO:0000087 CHEBI:33937 ! has role macronutrient
[Term]
id: CHEBI:22985
name: calcium molecular entity
subset: 3:STAR
synonym: "calcium compounds" RELATED [chebi]
synonym: "calcium molecular entities" RELATED [chebi]
synonym: "calcium molecular entity" RELATED [chebi]
is_a: CHEBI:33299 ! alkaline earth molecular entity
relationship: has_part CHEBI:22984 ! calcium atom
[Term]
id: CHEBI:23004
name: carbamoyl group
def: "The univalent carboacyl group formed by loss of -OH from the carboxy group of carbamic acid." []
subset: 3:STAR
synonym: "-C(O)NH2" RELATED [chebi]
synonym: "-CONH2" RELATED [iupac]
synonym: "aminocarbonyl" RELATED [iupac]
synonym: "carbamoyl" EXACT IUPAC:NAME [IUPAC]
synonym: "carbamoyl" RELATED IUPAC:NAME [iupac]
synonym: "carbamyl" RELATED [chebi]
synonym: "carbamyl group" RELATED [chebi]
synonym: "carboxamide" RELATED [iupac]
xref: pubmed:24168430 {source="pubmed"}
is_a: CHEBI:27207 ! univalent carboacyl group
relationship: RO:0018037 CHEBI:28616 ! is substitutent group from carbamic acid
[Term]
id: CHEBI:23014
name: carbon oxide
subset: 3:STAR
synonym: "carbon oxides" RELATED [chebi]
synonym: "oxides of carbon" RELATED [chebi]
is_a: CHEBI:25701 ! organic oxide
is_a: CHEBI:36963 ! organooxygen compound
[Term]
id: CHEBI:23016
name: carbonates
def: "Organooxygen compounds that are salts or esters of carbonic acid, H2CO3." []
subset: 3:STAR
is_a: CHEBI:36963 ! organooxygen compound
relationship: RO:0018038 CHEBI:28976 ! has functional parent carbonic acid
[Term]
id: CHEBI:23019
name: carbonyl group
subset: 3:STAR
synonym: ">C=O" RELATED [iupac]
synonym: "carbonyl" EXACT IUPAC:NAME [IUPAC]
synonym: "carbonyl" RELATED IUPAC:NAME [iupac]
synonym: "carbonyl group" RELATED [chebi, uniprot_ft]
is_a: CHEBI:51422 ! organodiyl group
[Term]
id: CHEBI:23042
name: carotene
def: "Hydrocarbon carotenoids." []
subset: 3:STAR
synonym: "carotene" RELATED [chebi]
synonym: "carotenes" EXACT IUPAC:NAME [IUPAC]
synonym: "carotenes" RELATED IUPAC:NAME [chebi, iupac]
is_a: CHEBI:35193 ! tetraterpene
[Term]
id: CHEBI:23044
name: carotenoid
def: "One of a class of tetraterpenoids (C40), formally derived from the acyclic parent, ψ,ψ-carotene by hydrogenation, dehydrogenation, cyclization, oxidation, or combination of these processes. This class includes carotenes, xanthophylls and certain compounds that arise from rearrangement of the skeleton of ψ,ψ-carotene or by loss of part of this structure. Retinoids are excluded." []
subset: 3:STAR
synonym: "carotenes and carotenoids" RELATED [chemidplus]
synonym: "carotenoid" EXACT IUPAC:NAME [IUPAC]
synonym: "carotenoid" RELATED IUPAC:NAME [iupac]
synonym: "carotenoids" RELATED [chebi]
xref: cas:36-88-4 {source="cas"}
is_a: CHEBI:26935 ! tetraterpenoid
relationship: RO:0018040 CHEBI:23042 ! has parent hydride carotene
[Term]
id: CHEBI:23045
name: carotenol
subset: 3:STAR
synonym: "carotenols" RELATED [chebi]
synonym: "hydroxycarotenoids" RELATED [chebi]
is_a: CHEBI:27325 ! xanthophyll
[Term]
id: CHEBI:23079
name: cerebroside
def: "Any member of a group of glycosphingolipids, also known as monoglycosylceramides, which are important components in animal muscle and nerve cell membranes." []
subset: 3:STAR
synonym: "cerebrosides" RELATED [chebi]
synonym: "monoglycosylceramide" RELATED [chebi]
synonym: "monoglycosylceramides" RELATED [chebi]
is_a: CHEBI:17761 ! ceramide
is_a: CHEBI:25513 ! neutral glycosphingolipid
[Term]
id: CHEBI:23213
name: choline ester
alt_id: CHEBI:3666
subset: 3:STAR
synonym: "choline esters" RELATED [chebi]
is_a: CHEBI:35701 ! ester
relationship: RO:0018038 CHEBI:15354 ! has functional parent choline
[Term]
id: CHEBI:23217
name: cholines
def: "A quaternary ammonium ion based on the choline ion and its substituted derivatives thereof." []
subset: 3:STAR
is_a: CHEBI:35267 ! quaternary ammonium ion
[Term]
id: CHEBI:23357
name: cofactor
def: "An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group)." []
subset: 3:STAR
synonym: "cofactor" RELATED [iupac]
synonym: "cofactors" EXACT IUPAC:NAME [IUPAC]
synonym: "cofactors" RELATED IUPAC:NAME [iupac]
xref: wikipedia.en:Cofactor_(biochemistry) {source="wikipedia.en"}
is_a: CHEBI:52206 ! biochemical role
[Term]
id: CHEBI:23367
name: molecular entity
def: "Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity." []
subset: 3:STAR
synonym: "entidad molecular" RELATED [iupac]
synonym: "entidades moleculares" RELATED [iupac]
synonym: "entite moleculaire" RELATED [iupac]
synonym: "molecular entities" RELATED [iupac]
synonym: "molecular entity" EXACT IUPAC:NAME [IUPAC]
synonym: "molecular entity" RELATED IUPAC:NAME [iupac]
synonym: "molekulare Entitaet" RELATED [chebi]
is_a: CHEBI:24431 ! chemical entity
[Term]
id: CHEBI:234420
name: (S)-noradrenaline(1+)
def: "An organic cation that is the conjugate acid of (S)-noradrenaline, obtained by protonation of the primary amino group; major species at pH 7.3." []
subset: 3:STAR
synonym: "(2S)-2-(3,4-dihydroxyphenyl)-2-hydroxyethan-1-aminium" RELATED [iupac]
synonym: "(2S)-2-(3,4-dihydroxyphenyl)-2-hydroxyethanaminium" EXACT IUPAC:NAME [IUPAC]
synonym: "(2S)-2-(3,4-dihydroxyphenyl)-2-hydroxyethanaminium" RELATED IUPAC:NAME [iupac]
synonym: "(S)-noradrenaline cation" RELATED [chebi]
synonym: "(S)-noradrenalinium cation" RELATED [chebi]
synonym: "(S)-noradrenalinium(1+)" RELATED [chebi]
is_a: CHEBI:166902 ! noradrenaline(1+)
relationship: RO:0018034 CHEBI:33571 ! is protonated form of (S)-noradrenaline
relationship: RO:0018039 CHEBI:72587 ! is enantiomer of (R)-noradrenaline(1+)
[Term]
id: CHEBI:23449
name: cyclic peptide
subset: 3:STAR
synonym: "cyclic peptides" RELATED [chebi]
synonym: "Cyclopeptid" RELATED [chebi]
synonym: "peptide cyclique" RELATED [iupac]
synonym: "peptido ciclico" RELATED [iupac]
synonym: "Zyklopeptid" RELATED [chebi]
is_a: CHEBI:16670 ! peptide
[Term]
id: CHEBI:23677
name: diazole
def: "An azole that is either one of a pair of heterocyclic organic compounds comprising three carbon atoms and two nitrogen atoms arranged in a ring." []
subset: 3:STAR
synonym: "diazoles" RELATED [chebi]
is_a: CHEBI:68452 ! azole
[Term]
id: CHEBI:237958
name: (\{[(2R,3S,4R,5R)-3,4-dihydroxy-5-(9H-purin-9-yl)oxolan-2-yl]methyl phosphonato\}oxy)(phosphonatooxy)phosphinate
subset: 2:STAR
is_a: CHEBI:37045 ! purine ribonucleoside 5'-triphosphate
is_a: CHEBI:37096 ! adenosine 5'-phosphate
relationship: RO:0000087 CHEBI:50733 ! has role nutraceutical
relationship: RO:0018034 CHEBI:57299 ! is protonated form of ATP(3-)
[Term]
id: CHEBI:23888
name: drug
def: "Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances." []
subset: 3:STAR
synonym: "drugs" RELATED [chebi]
synonym: "medicine" RELATED [chebi]
is_a: CHEBI:52217 ! pharmaceutical
[Term]
id: CHEBI:23906
name: monoatomic cation
subset: 3:STAR
synonym: "monoatomic cations" RELATED [chebi]
is_a: CHEBI:24867 ! monoatomic ion
is_a: CHEBI:36916 ! cation
[Term]
id: CHEBI:23924
name: enzyme inhibitor
def: "A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction." []
subset: 3:STAR
synonym: "enzyme inhibitor" EXACT IUPAC:NAME [IUPAC]
synonym: "enzyme inhibitor" RELATED IUPAC:NAME [iupac]
synonym: "enzyme inhibitors" RELATED [chebi]
synonym: "inhibidor enzimatico" RELATED [chebi]
synonym: "inhibidores enzimaticos" RELATED [chebi]
synonym: "inhibiteur enzymatique" RELATED [chebi]
synonym: "inhibiteurs enzymatiques" RELATED [chebi]
is_a: CHEBI:35222 ! inhibitor
is_a: CHEBI:52206 ! biochemical role
[Term]
id: CHEBI:24261
name: glucocorticoid
def: "Glucocorticoids are a class of steroid hormones that regulate a variety of physiological processes, in particular control of the concentration of glucose in blood." []
subset: 3:STAR
synonym: "glucocorticoids" RELATED [chebi]
is_a: CHEBI:36699 ! corticosteroid hormone
[Term]
id: CHEBI:24271
name: glucosamines
def: "Any hexosamine that is glucose in which at least one of the hydroxy groups has been replaced by an amino group." []
subset: 3:STAR
is_a: CHEBI:24586 ! hexosamine
[Term]
id: CHEBI:24318
name: glutamine family amino acid
def: "An L-α-amino acid which is L-glutamic acid or any of the essential amino acids biosynthesised from it (glutamine, proline and arginine). A closed class." []
subset: 3:STAR
synonym: "glutamine family amino acids" RELATED [chebi]
xref: pubmed:20716061 {source="pubmed"}
is_a: CHEBI:15705 ! L-alpha-amino acid
is_a: CHEBI:83813 ! proteinogenic amino acid
[Term]
id: CHEBI:24319
name: EC 6.3.1.2 (glutamate--ammonia ligase) inhibitor
def: "An EC 6.3.* (C‒N bond-forming ligase) inhibitor that interferes with the action of glutamate—ammonia ligase (EC 6.3.1.2)." []
subset: 3:STAR
synonym: "EC 6.3.1.2 (glutamate--ammonia ligase) inhibitors" RELATED [chebi]
synonym: "EC 6.3.1.2 inhibitor" RELATED [chebi]
synonym: "EC 6.3.1.2 inhibitors" RELATED [chebi]
synonym: "glutamate--ammonia ligase (EC 6.3.1.2) inhibitor" RELATED [chebi]
synonym: "glutamate--ammonia ligase (EC 6.3.1.2) inhibitors" RELATED [chebi]
synonym: "glutamate--ammonia ligase inhibitor" RELATED [chebi]
synonym: "glutamate--ammonia ligase inhibitors" RELATED [chebi]
synonym: "glutamine synthetase inhibitor" RELATED [chebi]
synonym: "glutamine synthetase inhibitors" RELATED [chebi]
synonym: "glutamylhydroxamic synthetase inhibitor" RELATED [chebi]
synonym: "glutamylhydroxamic synthetase inhibitors" RELATED [chebi]
synonym: "L-glutamate:ammonia ligase (ADP-forming) inhibitor" RELATED [chebi]
synonym: "L-glutamate:ammonia ligase (ADP-forming) inhibitors" RELATED [chebi]
synonym: "L-glutamine synthetase inhibitor" RELATED [chebi]
synonym: "L-glutamine synthetase inhibitors" RELATED [chebi]
xref: wikipedia.en:Glutamine_synthetase {source="wikipedia.en"}
is_a: CHEBI:76823 ! EC 6.3.1.* (acid-ammonia/amine ligase) inhibitor
[Term]
id: CHEBI:24384
name: glycogens
subset: 3:STAR
is_a: CHEBI:37163 ! glucan
[Term]
id: CHEBI:24402
name: glycosphingolipid
alt_id: CHEBI:5498
def: "A glycosphingolipid is a glycolipid that is a carbohydrate-containing derivative of a sphingoid or ceramide. It is understood that the carbohydrate residue is attached by a glycosidic linkage to O-1 of the sphingoid." []
subset: 3:STAR
synonym: "glycosphingolipids" RELATED [chebi]
xref: pubmed:18845618 {source="pubmed"}
xref: pubmed:19303901 {source="pubmed"}
xref: pubmed:26954668 {source="pubmed"}
xref: pubmed:26976737 {source="pubmed"}
xref: pubmed:27253729 {source="pubmed"}
xref: pubmed:27325407 {source="pubmed"}
xref: wikipedia.en:Glycosphingolipid {source="wikipedia.en"}
is_a: CHEBI:26739 ! sphingolipid
is_a: CHEBI:33563 ! glycolipid
[Term]
id: CHEBI:24431
name: chemical entity
def: "A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances." []
subset: 3:STAR
synonym: "chemical entity" RELATED [uniprot_ft]
[Term]
id: CHEBI:24432
name: biological role
def: "A role played by the molecular entity or part thereof within a biological context." []
subset: 3:STAR
synonym: "biological function" RELATED [chebi]
is_a: CHEBI:50906 ! role
[Term]
id: CHEBI:24433
name: group
def: "A defined linked collection of atoms or a single atom within a molecular entity." []
subset: 3:STAR
synonym: "group" EXACT IUPAC:NAME [IUPAC]
synonym: "group" RELATED IUPAC:NAME [iupac]
synonym: "groupe" RELATED [iupac]
synonym: "grupo" RELATED [iupac]
synonym: "grupos" RELATED [iupac]
synonym: "Gruppe" RELATED [chebi]
synonym: "Rest" RELATED [chebi]
is_a: CHEBI:24431 ! chemical entity
relationship: has_part CHEBI:33250 ! atom
[Term]
id: CHEBI:24532
name: organic heterocyclic compound
def: "A cyclic compound having as ring members atoms of carbon and at least of one other element." []
subset: 3:STAR
synonym: "organic heterocycle" RELATED [chebi]
synonym: "organic heterocyclic compounds" RELATED [chebi]
is_a: CHEBI:33285 ! heteroorganic entity
is_a: CHEBI:33832 ! organic cyclic compound
is_a: CHEBI:5686 ! heterocyclic compound
[Term]
id: CHEBI:24533
name: heterodetic cyclic peptide
def: "A heterodetic cyclic peptide is a peptide consisting only of amino-acid residues, but in which the linkages forming the ring are not solely peptide bonds; one or more is an isopeptide, disulfide, ester, or other bond." []
subset: 3:STAR
synonym: "heterodetic cyclic peptide" EXACT IUPAC:NAME [IUPAC]
synonym: "heterodetic cyclic peptide" RELATED IUPAC:NAME [iupac]
synonym: "heterodetic cyclic peptides" RELATED [chebi]
synonym: "peptide cyclique heterodetique" RELATED [iupac]
synonym: "peptido ciclico heterodetico" RELATED [iupac]
is_a: CHEBI:23449 ! cyclic peptide
[Term]
id: CHEBI:24586
name: hexosamine
def: "Any 6-carbon amino monosaccharide with at least one alcoholic hydroxy group replaced by an amino group." []
subset: 3:STAR
synonym: "hexosamine" RELATED [chebi]
synonym: "hexosamines" RELATED [chebi]
is_a: CHEBI:60926 ! amino monosaccharide
[Term]
id: CHEBI:24621
name: hormone
def: "Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds." []
subset: 3:STAR
synonym: "endocrine" RELATED [chebi]
synonym: "hormones" RELATED [chebi]
is_a: CHEBI:33280 ! molecular messenger
is_a: CHEBI:48705 ! agonist
[Term]
id: CHEBI:24632
name: hydrocarbon
def: "A compound consisting of carbon and hydrogen only." []
subset: 3:STAR
synonym: "hidrocarburo" RELATED [iupac]
synonym: "hidrocarburos" RELATED [iupac]
synonym: "hydrocarbon" EXACT IUPAC:NAME [IUPAC]
synonym: "hydrocarbon" RELATED IUPAC:NAME [iupac]
synonym: "hydrocarbons" EXACT IUPAC:NAME [IUPAC]
synonym: "hydrocarbons" RELATED IUPAC:NAME [iupac]
synonym: "hydrocarbure" RELATED [iupac]
synonym: "Kohlenwasserstoff" RELATED [chebi]
synonym: "Kohlenwasserstoffe" RELATED [chebi]
is_a: CHEBI:33245 ! organic fundamental parent
[Term]
id: CHEBI:24636
name: proton
def: "Nuclear particle of charge number +1, spin 1/2 and rest mass of 1.007276470(12) u." []
subset: 3:STAR
synonym: "(1)1H(+)" RELATED [iupac]
synonym: "(1)H(+)" RELATED [iupac]
synonym: "p" RELATED [iupac]
synonym: "p(+)" RELATED [iupac]
synonym: "protium(1+)" EXACT IUPAC:NAME [IUPAC]
synonym: "protium(1+)" RELATED IUPAC:NAME [iupac]
synonym: "proton" EXACT IUPAC:NAME [IUPAC]
synonym: "proton" RELATED IUPAC:NAME [chebi, iupac]
xref: cas:12408-02-5 {source="cas"}
xref: kegg.compound:C00080 {source="kegg.compound"}
is_a: CHEBI:15378 ! hydron
is_a: CHEBI:33253 ! nucleon
[Term]
id: CHEBI:24651
name: hydroxides
def: "Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH−)." []
subset: 3:STAR
is_a: CHEBI:25806 ! oxygen molecular entity
is_a: CHEBI:33608 ! hydrogen molecular entity
is_a: CHEBI:37577 ! heteroatomic molecular entity
relationship: has_part CHEBI:43176 ! hydroxy group
[Term]
id: CHEBI:24663
name: hydroxy-5beta-cholanic acid
def: "Any member of the class of 5β-cholanic acids carrying at least one hydroxy group at unspecified position." []
subset: 3:STAR
synonym: "hydroxy-5beta-cholanic acids" RELATED [chebi]
is_a: CHEBI:33822 ! organic hydroxy compound
is_a: CHEBI:36248 ! 5beta-cholanic acids
relationship: RO:0018038 CHEBI:36238 ! has functional parent 5beta-cholanic acid
[Term]
id: CHEBI:24780
name: imidazoles
def: "A five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton." []
subset: 3:STAR
is_a: CHEBI:23677 ! diazole
[Term]
id: CHEBI:24828
name: indoles
def: "Any compound containing an indole skeleton." []
subset: 3:STAR
is_a: CHEBI:22728 ! benzopyrrole
[Term]
id: CHEBI:24833
name: oxoacid
def: "A compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." []
subset: 3:STAR
synonym: "oxacids" RELATED [chebi]
synonym: "oxiacids" RELATED [chebi]
synonym: "oxo acid" RELATED [chebi]
synonym: "oxoacid" EXACT IUPAC:NAME [IUPAC]
synonym: "oxoacid" RELATED IUPAC:NAME [iupac]
synonym: "oxoacids" EXACT IUPAC:NAME [IUPAC]
synonym: "oxoacids" RELATED IUPAC:NAME [iupac]
synonym: "oxy-acids" RELATED [chebi]
synonym: "oxyacids" RELATED [chebi]
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:24651 ! hydroxides
relationship: RO:0000087 CHEBI:39141 ! has role Bronsted acid
[Term]
id: CHEBI:24834
name: inorganic anion
subset: 3:STAR
synonym: "inorganic anions" RELATED [chebi]
is_a: CHEBI:22563 ! anion
is_a: CHEBI:36914 ! inorganic ion
[Term]
id: CHEBI:24835
name: inorganic molecular entity
def: "A molecular entity that contains no carbon." []
subset: 3:STAR
synonym: "anorganische Verbindungen" RELATED [chebi]
synonym: "inorganic compounds" RELATED [chebi]
synonym: "inorganic entity" RELATED [chebi]
synonym: "inorganic molecular entities" RELATED [chebi]
synonym: "inorganics" RELATED [chebi]
is_a: CHEBI:23367 ! molecular entity
[Term]
id: CHEBI:24836
name: inorganic oxide
subset: 3:STAR
synonym: "inorganic oxides" RELATED [chebi]
is_a: CHEBI:24835 ! inorganic molecular entity
is_a: CHEBI:25741 ! oxide
[Term]
id: CHEBI:24839
name: inorganic salt
subset: 3:STAR
synonym: "anorganisches Salz" RELATED [chebi]
synonym: "inorganic salts" RELATED [chebi]
is_a: CHEBI:24835 ! inorganic molecular entity
is_a: CHEBI:24866 ! salt
[Term]
id: CHEBI:24866
name: salt
def: "A salt is an assembly of cations and anions." []
subset: 3:STAR
synonym: "ionic compound" RELATED [chebi]
synonym: "ionic compounds" RELATED [chebi]
synonym: "sal" RELATED [chebi]
synonym: "sales" RELATED [chebi]
synonym: "salt" EXACT IUPAC:NAME [IUPAC]
synonym: "salt" RELATED IUPAC:NAME [iupac]
synonym: "salts" RELATED [chebi]
synonym: "Salz" RELATED [chebi]
synonym: "Salze" RELATED [chebi]
synonym: "sel" RELATED [chebi]
synonym: "sels" RELATED [chebi]
is_a: CHEBI:37577 ! heteroatomic molecular entity
relationship: has_part CHEBI:22563 ! anion
relationship: has_part CHEBI:36916 ! cation
[Term]
id: CHEBI:24867
name: monoatomic ion
subset: 3:STAR
synonym: "monoatomic ions" RELATED [chebi]
is_a: CHEBI:24870 ! ion
is_a: CHEBI:33238 ! monoatomic entity
[Term]
id: CHEBI:24868
name: organic salt
subset: 3:STAR
synonym: "organic salts" RELATED [chebi]
synonym: "organisches Salz" RELATED [chebi]
is_a: CHEBI:24866 ! salt
[Term]
id: CHEBI:24870
name: ion
def: "A molecular entity having a net electric charge." []
subset: 3:STAR
synonym: "Ion" RELATED [chebi]
synonym: "ion" EXACT IUPAC:NAME [IUPAC]
synonym: "ion" RELATED IUPAC:NAME [chebi, iupac]
synonym: "Ionen" RELATED [chebi]
synonym: "iones" RELATED [chebi]
synonym: "ions" RELATED [chebi]
is_a: CHEBI:23367 ! molecular entity
[Term]
id: CHEBI:24873
name: iron molecular entity
subset: 3:STAR
synonym: "iron compounds" RELATED [chebi]
synonym: "iron molecular entities" RELATED [chebi]
synonym: "iron molecular entity" RELATED [chebi]
is_a: CHEBI:33744 ! iron group molecular entity
relationship: has_part CHEBI:18248 ! iron atom
[Term]
id: CHEBI:24875
name: iron cation
subset: 3:STAR
synonym: "Fe cation" RELATED [uniprot_ft]
synonym: "iron cation" EXACT IUPAC:NAME [IUPAC]
synonym: "iron cation" RELATED IUPAC:NAME [iupac]
synonym: "iron cations" RELATED [chebi]
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:33515 ! transition element cation
is_a: CHEBI:82663 ! elemental iron
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
[Term]
id: CHEBI:24913
name: isoprenoid
def: "Any lipid formally derived from isoprene (2-methylbuta-1,3-diene), the skeleton of which can generally be discerned in repeated occurrence in the molecule. The skeleton of isoprenoids may differ from strict additivity of isoprene units by loss or shift of a fragment, commonly a methyl group. The class includes both hydrocarbons and oxygenated derivatives." []
subset: 3:STAR
synonym: "isoprenoid" RELATED [chebi]
synonym: "isoprenoids" EXACT IUPAC:NAME [IUPAC]
synonym: "isoprenoids" RELATED IUPAC:NAME [chebi, iupac]
xref: lipidmaps_class:LMPR01 {source="lipidmaps_class"}
xref: pubmed:12769708 {source="pubmed"}
xref: pubmed:19219049 {source="pubmed"}
is_a: CHEBI:18059 ! lipid
[Term]
id: CHEBI:24943
name: juvenile hormone
def: "A family of farnesane sesquiterpenoids that regulate many aspects of insect physiology." []
subset: 3:STAR
xref: wikipedia.en:Juvenile_hormone {source="wikipedia.en"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:36757 ! farnesane sesquiterpenoid
relationship: RO:0000087 CHEBI:24621 ! has role hormone
relationship: RO:0000087 CHEBI:75767 ! has role animal metabolite
[Term]
id: CHEBI:25046
name: linear tetrapyrrole
subset: 1:STAR
synonym: "linear tetrapyrroles" RELATED [chebi]
is_a: CHEBI:26932 ! tetrapyrrole
[Term]
id: CHEBI:25212
name: metabolite
alt_id: CHEBI:26619
alt_id: CHEBI:35220
def: "Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites." []
subset: 3:STAR
synonym: "metabolite" EXACT IUPAC:NAME [IUPAC]
synonym: "metabolite" RELATED IUPAC:NAME [iupac]
synonym: "metabolites" RELATED [chebi]
synonym: "primary metabolites" RELATED [chebi]
synonym: "secondary metabolites" RELATED [chebi]
is_a: CHEBI:52206 ! biochemical role
[Term]
id: CHEBI:25213
name: metal cation
subset: 3:STAR
synonym: "a metal cation" RELATED [uniprot_ft]
synonym: "metal cations" RELATED [chebi]
is_a: CHEBI:23906 ! monoatomic cation
is_a: CHEBI:36915 ! inorganic cation
[Term]
id: CHEBI:25354
name: mineralocorticoid
def: "Mineralocorticoids are a class of steroid hormones that regulate water and electrolyte metabolism." []
subset: 3:STAR
synonym: "mineralocorticoids" RELATED [chebi]
is_a: CHEBI:36699 ! corticosteroid hormone
[Term]
id: CHEBI:25362
name: elemental molecule
def: "A molecule all atoms of which have the same atomic number." []
subset: 3:STAR
synonym: "homoatomic molecule" RELATED [chebi]
synonym: "homoatomic molecules" RELATED [chebi]
is_a: CHEBI:25367 ! molecule
is_a: CHEBI:33259 ! elemental molecular entity
[Term]
id: CHEBI:25367
name: molecule
def: "Any polyatomic entity that is an electrically neutral entity consisting of more than one atom." []
subset: 3:STAR
synonym: "molecula" RELATED [iupac]
synonym: "molecule" RELATED [iupac]
synonym: "molecules" RELATED [iupac]
synonym: "Molekuel" RELATED [chebi]
synonym: "neutral molecular compounds" RELATED [iupac]
is_a: CHEBI:36357 ! polyatomic entity
[Term]
id: CHEBI:25375
name: monoamine molecular messenger
def: "A group of neurotransmitters and neuromodulators that contain one amino group that is connected to an aromatic ring by ethylene group (‒CH2‒CH2‒). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan." []
subset: 3:STAR
synonym: "monamines" RELATED [chebi]
synonym: "monoamines" RELATED [chebi]
is_a: CHEBI:63534 ! monoamine
relationship: RO:0000087 CHEBI:33280 ! has role molecular messenger
[Term]
id: CHEBI:25384
name: monocarboxylic acid
def: "An oxoacid containing a single carboxy group." []
subset: 3:STAR
synonym: "monocarboxylic acids" RELATED [chebi]
is_a: CHEBI:33575 ! carboxylic acid
relationship: RO:0018034 CHEBI:35757 ! is protonated form of monocarboxylic acid anion
[Term]
id: CHEBI:25414
name: monoatomic monocation
subset: 3:STAR
synonym: "monoatomic monocations" RELATED [chebi]
synonym: "monovalent inorganic cations" RELATED [chebi]
is_a: CHEBI:23906 ! monoatomic cation
[Term]
id: CHEBI:25512
name: neurotransmitter
def: "An endogenous compound that is used to transmit information across the synapse between a neuron and another cell." []
subset: 3:STAR
synonym: "neurotransmitters" RELATED [chebi]
xref: wikipedia.en:Neurotransmitter {source="wikipedia.en"}
is_a: CHEBI:33280 ! molecular messenger
[Term]
id: CHEBI:25513
name: neutral glycosphingolipid
alt_id: CHEBI:7543
def: "Any glycosphingolipid containing unsubstituted glycosyl moieties." []
subset: 3:STAR
synonym: "neutral glycosphingolipids" RELATED [chebi]
is_a: CHEBI:24402 ! glycosphingolipid
[Term]
id: CHEBI:25555
name: nitrogen atom
subset: 3:STAR
synonym: "7N" RELATED [iupac]
synonym: "azote" RELATED [iupac]
synonym: "N" RELATED [iupac]
synonym: "nitrogen" EXACT IUPAC:NAME [IUPAC]
synonym: "nitrogen" RELATED IUPAC:NAME [chebi, iupac]
synonym: "nitrogeno" RELATED [chebi]
synonym: "Stickstoff" RELATED [chebi]
xref: webelements:N {source="webelements"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33300 ! pnictogen
relationship: RO:0000087 CHEBI:33937 ! has role macronutrient
[Term]
id: CHEBI:25585
name: nonmetal atom
subset: 3:STAR
synonym: "Nichtmetall" RELATED [chebi]
synonym: "Nichtmetalle" RELATED [chebi]
synonym: "no metal" RELATED [chebi]
synonym: "no metales" RELATED [chebi]
synonym: "non-metal" RELATED [chebi]
synonym: "non-metaux" RELATED [chebi]
synonym: "nonmetal" EXACT IUPAC:NAME [IUPAC]
synonym: "nonmetal" RELATED IUPAC:NAME [chebi, iupac]
synonym: "nonmetals" RELATED [chebi]
is_a: CHEBI:33250 ! atom
[Term]
id: CHEBI:25608
name: nucleoside phosphate
def: "A nucleobase-containing molecular entity that is a nucleoside in which one or more of the sugar hydroxy groups has been converted into a mono- or poly-phosphate. The term includes both nucleotides and non-nucleotide nucleoside phosphates." []
subset: 3:STAR
synonym: "NMP" RELATED [kegg.compound]
synonym: "nucleoside phosphates" RELATED [chebi]
xref: kegg.compound:C01329 {source="kegg.compound"}
is_a: CHEBI:25703 ! organic phosphate
is_a: CHEBI:37734 ! phosphoric ester
is_a: CHEBI:61120 ! nucleobase-containing molecular entity
relationship: RO:0018038 CHEBI:33838 ! has functional parent nucleoside
[Term]
id: CHEBI:25693
name: organic heteromonocyclic compound
subset: 3:STAR
synonym: "organic heteromonocyclic compounds" RELATED [chebi]
is_a: CHEBI:24532 ! organic heterocyclic compound
is_a: CHEBI:33670 ! heteromonocyclic compound
[Term]
id: CHEBI:25696
name: organic anion
def: "Any organic ion with a net negative charge." []
subset: 3:STAR
synonym: "organic anions" RELATED [chebi]
is_a: CHEBI:22563 ! anion
is_a: CHEBI:25699 ! organic ion
[Term]
id: CHEBI:25697
name: organic cation
def: "Any organic ion with a net positive charge." []
subset: 3:STAR
synonym: "organic cations" RELATED [chebi]
is_a: CHEBI:25699 ! organic ion
is_a: CHEBI:36916 ! cation
[Term]
id: CHEBI:25699
name: organic ion
subset: 3:STAR
synonym: "organic ions" RELATED [chebi]
is_a: CHEBI:24870 ! ion
is_a: CHEBI:50860 ! organic molecular entity
[Term]
id: CHEBI:25701
name: organic oxide
def: "An oxide in which the oxygen atom is bonded to a carbon atom." []
subset: 3:STAR
synonym: "organic oxides" RELATED [chebi]
is_a: CHEBI:25741 ! oxide
is_a: CHEBI:72695 ! organic molecule
[Term]
id: CHEBI:25703
name: organic phosphate
subset: 3:STAR
synonym: "organic phosphate" RELATED [chebi]
synonym: "organic phosphate ester" RELATED [chebi]
synonym: "organic phosphate esters" RELATED [chebi]
synonym: "organic phosphates" RELATED [chebi]
synonym: "organophosphate ester" RELATED [chebi]
synonym: "organophosphate esters" RELATED [chebi]
xref: wikipedia.en:Organophosphate {source="wikipedia.en"}
is_a: CHEBI:25710 ! organophosphorus compound
is_a: CHEBI:26020 ! phosphate
[Term]
id: CHEBI:25704
name: organic sulfate
def: "Compounds of the general formula SO3HOR where R is an organyl group" []
subset: 3:STAR
synonym: "organic sulfates" RELATED [chebi]
is_a: CHEBI:26820 ! sulfates
relationship: RO:0018034 CHEBI:58958 ! is protonated form of organosulfate oxoanion
[Term]
id: CHEBI:25710
name: organophosphorus compound
def: "An organophosphorus compound is formally a compound containing at least one carbon-phosphorus bond, but the term is often extended to include esters and thioesters." []
subset: 3:STAR
synonym: "organophosphorus compound" RELATED [chebi]
synonym: "organophosphorus compounds" RELATED [chebi]
xref: wikipedia.en:Organophosphorus_compound {source="wikipedia.en"}
is_a: CHEBI:26082 ! phosphorus molecular entity
is_a: CHEBI:33285 ! heteroorganic entity
[Term]
id: CHEBI:25741
name: oxide
def: "An oxide is a chemical compound of oxygen with other chemical elements." []
subset: 3:STAR
synonym: "oxide" RELATED [chebi]
synonym: "oxides" RELATED [chebi]
is_a: CHEBI:25806 ! oxygen molecular entity
is_a: CHEBI:37577 ! heteroatomic molecular entity
[Term]
id: CHEBI:25754
name: oxo carboxylic acid
def: "Any compound that has an aldehydic or ketonic group as well as a carboxylic acid group in the same molecule." []
subset: 3:STAR
synonym: "oxo acids" RELATED [iupac]
synonym: "oxo carboxylic acids" EXACT IUPAC:NAME [IUPAC]
synonym: "oxo carboxylic acids" RELATED IUPAC:NAME [chebi, iupac]
is_a: CHEBI:33575 ! carboxylic acid
relationship: RO:0018034 CHEBI:35903 ! is protonated form of oxo carboxylic acid anion
[Term]
id: CHEBI:25805
name: oxygen atom
subset: 3:STAR
synonym: "8O" RELATED [iupac]
synonym: "O" RELATED [iupac]
synonym: "oxigeno" RELATED [chebi]
synonym: "oxygen" EXACT IUPAC:NAME [IUPAC]
synonym: "oxygen" RELATED IUPAC:NAME [chebi, iupac]
synonym: "oxygene" RELATED [chebi]
synonym: "Sauerstoff" RELATED [chebi]
xref: kegg.compound:C00007 {source="kegg.compound"}
xref: webelements:O {source="webelements"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33303 ! chalcogen
relationship: RO:0000087 CHEBI:33937 ! has role macronutrient
[Term]
id: CHEBI:25806
name: oxygen molecular entity
subset: 3:STAR
synonym: "oxygen molecular entities" RELATED [chebi]
synonym: "oxygen molecular entity" RELATED [chebi]
is_a: CHEBI:33304 ! chalcogen molecular entity
relationship: has_part CHEBI:25805 ! oxygen atom
[Term]
id: CHEBI:25900
name: aldopentose phosphate
subset: 3:STAR
synonym: "aldopentose phosphate" RELATED [chebi]
synonym: "aldopentose phosphates" RELATED [chebi]
is_a: CHEBI:35131 ! aldose phosphate
is_a: CHEBI:84055 ! pentose phosphate
[Term]
id: CHEBI:25901
name: pentose
def: "A five-carbon monosaccharide which in its linear form contains either an aldehyde group at position 1 (aldopentose) or a ketone group at position 2 (ketopentose)." []
subset: 3:STAR
synonym: "pentose" RELATED [chebi]
synonym: "pentoses" RELATED [chebi]
is_a: CHEBI:35381 ! monosaccharide
[Term]
id: CHEBI:25905
name: peptide hormone
def: "Any peptide with hormonal activity in animals, whether endocrine, neuroendocrine, or paracrine." []
subset: 3:STAR
synonym: "peptide hormones" RELATED [chebi]
synonym: "polypeptide hormone" RELATED [chebi]
is_a: CHEBI:16670 ! peptide
relationship: RO:0000087 CHEBI:24621 ! has role hormone
[Term]
id: CHEBI:25985
name: phenylalanine derivative
def: "An amino acid derivative resulting from reaction of alanine at the amino group or the carboxy group, or from the replacement of any hydrogen of phenylalanine by a heteroatom. The definition normally excludes peptides containing phenylalanine residues." []
subset: 3:STAR
is_a: CHEBI:83821 ! amino-acid derivative
relationship: RO:0018038 CHEBI:28044 ! has functional parent phenylalanine
[Term]
id: CHEBI:26020
name: phosphate
def: "Salts and esters of phosphoric and oligophosphoric acids and their chalcogen analogues. In inorganic chemistry, the term is also used to describe anionic coordination entities with phosphorus as central atom." []
subset: 3:STAR
synonym: "phosphates" EXACT IUPAC:NAME [IUPAC]
synonym: "phosphates" RELATED IUPAC:NAME [chebi, iupac]
is_a: CHEBI:26079 ! phosphoric acid derivative
[Term]
id: CHEBI:26051
name: phosphoamino acid
subset: 3:STAR
synonym: "phosphoamino acids" RELATED [chebi]
is_a: CHEBI:83821 ! amino-acid derivative
[Term]
id: CHEBI:26078
name: phosphoric acid
def: "A phosphorus oxoacid that consists of one oxo and three hydroxy groups joined covalently to a central phosphorus atom." []
subset: 3:STAR
synonym: "[PO(OH)3]" RELATED [iupac]
synonym: "acide phosphorique" RELATED [chebi]
synonym: "acidum phosphoricum" RELATED [chebi]
synonym: "H3PO4" RELATED [iupac]
synonym: "Orthophosphoric acid" RELATED [kegg.compound]
synonym: "orthophosphoric acid" RELATED [nist]
synonym: "Phosphate" RELATED [kegg.compound]
synonym: "Phosphoric acid" RELATED [kegg.compound]
synonym: "phosphoric acid" RELATED [iupac]
synonym: "Phosphorsaeure" RELATED [chebi]
synonym: "Phosphorsaeureloesungen" RELATED [chebi]
synonym: "tetraoxophosphoric acid" EXACT IUPAC:NAME [IUPAC]
synonym: "tetraoxophosphoric acid" RELATED IUPAC:NAME [iupac]
synonym: "trihydrogen tetraoxophosphate(3-)" EXACT IUPAC:NAME [IUPAC]
synonym: "trihydrogen tetraoxophosphate(3-)" RELATED IUPAC:NAME [iupac]
synonym: "trihydroxidooxidophosphorus" EXACT IUPAC:NAME [IUPAC]
synonym: "trihydroxidooxidophosphorus" RELATED IUPAC:NAME [iupac]
xref: cas:7664-38-2 {source="cas"}
xref: drugcentral:4478 {source="drugcentral"}
xref: gmelin:2000 {source="gmelin"}
xref: hmdb:HMDB0002142 {source="hmdb"}
xref: kegg.compound:C00009 {source="kegg.compound"}
xref: kegg.drug:D05467 {source="kegg.drug"}
xref: knapsack:C00007408 {source="knapsack"}
xref: pubmed:11455380 {source="pubmed"}
xref: pubmed:15630224 {source="pubmed"}
xref: pubmed:17439666 {source="pubmed"}
xref: pubmed:17518491 {source="pubmed"}
xref: pubmed:22282755 {source="pubmed"}
xref: pubmed:22333268 {source="pubmed"}
xref: pubmed:22381614 {source="pubmed"}
xref: pubmed:22401268 {source="pubmed"}
xref: reaxys:1921286 {source="reaxys"}
xref: wikipedia.en:Phosphoric_Acid {source="wikipedia.en"}
is_a: CHEBI:59698 ! phosphoric acids
relationship: RO:0000087 CHEBI:228364 ! has role NMR chemical shift reference compound
relationship: RO:0000087 CHEBI:33287 ! has role fertilizer
relationship: RO:0000087 CHEBI:46787 ! has role solvent
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0000087 CHEBI:84735 ! has role algal metabolite
relationship: RO:0018034 CHEBI:35780 ! is protonated form of phosphate ion
relationship: RO:0018034 CHEBI:39745 ! is protonated form of dihydrogenphosphate
[Term]
id: CHEBI:26079
name: phosphoric acid derivative
subset: 1:STAR
synonym: "phosphoric acid derivatives" RELATED [chebi]
synonym: "phosphoric acids" RELATED [chebi]
is_a: CHEBI:36359 ! phosphorus oxoacid derivative
relationship: RO:0018038 CHEBI:26078 ! has functional parent phosphoric acid
[Term]
id: CHEBI:26082
name: phosphorus molecular entity
subset: 3:STAR
synonym: "phosphorus molecular entities" RELATED [chebi]
is_a: CHEBI:33302 ! pnictogen molecular entity
relationship: has_part CHEBI:28659 ! phosphorus atom
[Term]
id: CHEBI:26130
name: biological pigment
def: "An endogenous molecular entity that results in a colour of an organism as the consequence of the selective absorption of light." []
subset: 3:STAR
synonym: "pigments" RELATED [chebi]
is_a: CHEBI:52208 ! biophysical role
[Term]
id: CHEBI:26167
name: polar amino acid
alt_id: CHEBI:8283
def: "Any amino acid whose side chain is capable of forming one or more hydrogen bonds." []
subset: 3:STAR
synonym: "polar amino acid" RELATED [chebi]
synonym: "polar amino acids" RELATED [chebi]
synonym: "polar amino-acid" RELATED [chebi]
synonym: "polar amino-acids" RELATED [chebi]
xref: metacyc.compound:Polar-amino-acids {source="metacyc.compound"}
xref: pubmed:12016058 {source="pubmed"}
is_a: CHEBI:33709 ! amino acid
relationship: RO:0018036 CHEBI:62031 ! is tautomer of polar amino acid zwitterion
[Term]
id: CHEBI:26214
name: porphyrins
def: "Natural pigments containing a fundamental skeleton of four pyrrole nuclei united through the α-positions by four methine groups to form a macrocyclic structure." []
subset: 3:STAR
synonym: "porphyrins" EXACT IUPAC:NAME [IUPAC]
synonym: "porphyrins" RELATED IUPAC:NAME [iupac]
xref: wikipedia.en:Porphyrin {source="wikipedia.en"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:36309 ! cyclic tetrapyrrole
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
[Term]
id: CHEBI:26216
name: potassium atom
subset: 3:STAR
synonym: "19K" RELATED [iupac]
synonym: "K" RELATED [iupac]
synonym: "Kalium" RELATED [chemidplus]
synonym: "kalium" RELATED [iupac]
synonym: "potasio" RELATED [chebi]
synonym: "potassium" EXACT IUPAC:NAME [IUPAC]
synonym: "potassium" RELATED IUPAC:NAME [chebi, iupac]
xref: cas:7440-09-7 {source="cas"}
xref: drugbank:DB01345 {source="drugbank"}
xref: kegg.compound:C00238 {source="kegg.compound"}
xref: webelements:K {source="webelements"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:22314 ! alkali metal atom
relationship: RO:0000087 CHEBI:33937 ! has role macronutrient
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
[Term]
id: CHEBI:26217
name: potassium molecular entity
subset: 3:STAR
synonym: "potassium molecular entities" RELATED [chebi]
synonym: "potassium molecular entity" RELATED [chebi]
is_a: CHEBI:33296 ! alkali metal molecular entity
relationship: has_part CHEBI:26216 ! potassium atom
[Term]
id: CHEBI:26386
name: purine nucleobase
def: "A nucleobase whose skeleton is derived from purine." []
subset: 3:STAR
synonym: "a purine nucleobase" RELATED [uniprot_ft]
synonym: "purine bases" RELATED [chebi]
synonym: "purine nucleobase" RELATED [chebi]
synonym: "purine nucleobases" RELATED [chebi]
xref: kegg.compound:C15587 {source="kegg.compound"}
is_a: CHEBI:18282 ! nucleobase
is_a: CHEBI:26401 ! purines
[Term]
id: CHEBI:26391
name: purine nucleoside diphosphate
subset: 3:STAR
synonym: "purine nucleoside diphosphates" RELATED [chebi]
is_a: CHEBI:16862 ! nucleoside 5'-diphosphate
[Term]
id: CHEBI:26393
name: purine nucleoside triphosphate
subset: 3:STAR
synonym: "purine nucleoside triphosphates" RELATED [chebi]
is_a: CHEBI:17326 ! nucleoside 5'-triphoshate
[Term]
id: CHEBI:26394
name: purine nucleoside
subset: 3:STAR
synonym: "purine nucleoside" RELATED [chebi]
synonym: "purine nucleosides" RELATED [chebi]
is_a: CHEBI:26401 ! purines
is_a: CHEBI:33838 ! nucleoside
[Term]
id: CHEBI:26395
name: purine nucleotide
def: "Any nucleotide that has a purine nucleobase." []
subset: 3:STAR
synonym: "purine nucleotides" RELATED [chebi]
is_a: CHEBI:26401 ! purines
is_a: CHEBI:36976 ! nucleotide
[Term]
id: CHEBI:26396
name: purine ribonucleoside diphosphate
subset: 3:STAR
synonym: "purine ribonucleoside diphosphates" RELATED [chebi]
is_a: CHEBI:17668 ! ribonucleoside diphosphat
is_a: CHEBI:26391 ! purine nucleoside diphosphate
[Term]
id: CHEBI:26398
name: purine ribonucleoside triphosphate
subset: 3:STAR
synonym: "purine ribonucleoside triphosphates" RELATED [chebi]
is_a: CHEBI:17972 ! ribonucleoside triphosphate
is_a: CHEBI:26393 ! purine nucleoside triphosphate
[Term]
id: CHEBI:26399
name: purine ribonucleoside
def: "A ribonucleoside that has a purine moiety as the nucleobase (the R group in the illustration)." []
subset: 3:STAR
synonym: "purine ribonucleosides" RELATED [chebi]
is_a: CHEBI:18254 ! ribonucleoside
is_a: CHEBI:26394 ! purine nucleoside
[Term]
id: CHEBI:26400
name: purine ribonucleotide
def: "Any ribonucleotide that has a purine nucleobase." []
subset: 3:STAR
synonym: "purine ribonucleotides" RELATED [chebi]
is_a: CHEBI:26395 ! purine nucleotide
is_a: CHEBI:26561 ! ribonucleotide
[Term]
id: CHEBI:26401
name: purines
alt_id: CHEBI:13678
def: "A class of imidazopyrimidines that consists of purine and its substituted derivatives." []
subset: 3:STAR
is_a: CHEBI:35875 ! imidazopyrimidine
[Term]
id: CHEBI:26469
name: quaternary nitrogen compound
def: "A nitrogen molecular entity that is electronically neutral but which contains a quaternary nitrogen." []
subset: 3:STAR
is_a: CHEBI:35352 ! organonitrogen compound
relationship: has_part CHEBI:35267 ! quaternary ammonium ion
[Term]
id: CHEBI:26561
name: ribonucleotide
subset: 3:STAR
synonym: "ribonucleotides" RELATED [chebi]
is_a: CHEBI:26562 ! ribose phosphate
is_a: CHEBI:36976 ! nucleotide
[Term]
id: CHEBI:26562
name: ribose phosphate
subset: 3:STAR
synonym: "ribose phosphate" RELATED [chebi]
synonym: "ribose phosphates" RELATED [chebi]
is_a: CHEBI:25900 ! aldopentose phosphate
[Term]
id: CHEBI:26607
name: saturated fatty acid
def: "Any fatty acid containing no carbon to carbon multiple bonds. Known to produce adverse biological effects when ingested to excess." []
subset: 3:STAR
synonym: "saturated fatty acid" RELATED [chebi]
synonym: "saturated fatty acids" RELATED [chebi]
synonym: "SFA" RELATED [chebi]
synonym: "SFAs" RELATED [chebi]
xref: pubmed:16492686 {source="pubmed"}
xref: pubmed:19763019 {source="pubmed"}
xref: pubmed:20237329 {source="pubmed"}
is_a: CHEBI:35366 ! fatty acid
[Term]
id: CHEBI:26658
name: sesquiterpenoid
def: "Any terpenoid derived from a sesquiterpene. The term includes compounds in which the C15 skeleton of the parent sesquiterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups)." []
subset: 3:STAR
synonym: "sesquiterpenoides" RELATED [chebi]
synonym: "sesquiterpenoids" RELATED [chebi]
xref: lipidmaps_class:LMPR0103 {source="lipidmaps_class"}
is_a: CHEBI:26873 ! terpenoid
relationship: RO:0018040 CHEBI:35189 ! has parent hydride sesquiterpene
[Term]
id: CHEBI:26666
name: short-chain fatty acid
def: "An aliphatic monocarboxylic acid with a chain length of less than C6. If any non-hydrocarbon substituent is present, the compound is not normally regarded as a short-chain fatty acid." []
subset: 3:STAR
synonym: "SCFA" RELATED [chebi]
synonym: "SCFAs" RELATED [chebi]
synonym: "short-chain fatty acids" RELATED [chebi]
xref: pubmed:16633129 {source="pubmed"}
xref: pubmed:16870803 {source="pubmed"}
xref: pubmed:18203540 {source="pubmed"}
xref: pubmed:20148677 {source="pubmed"}
is_a: CHEBI:35366 ! fatty acid
relationship: RO:0018034 CHEBI:58951 ! is protonated form of short-chain fatty acid anion
[Term]
id: CHEBI:26708
name: sodium atom
subset: 3:STAR
synonym: "11Na" RELATED [iupac]
synonym: "Na" RELATED [iupac]
synonym: "Natrium" RELATED [chemidplus]
synonym: "natrium" RELATED [iupac]
synonym: "sodio" RELATED [chemidplus]
synonym: "sodium" EXACT IUPAC:NAME [IUPAC]
synonym: "sodium" RELATED IUPAC:NAME [chebi, iupac]
xref: cas:7440-23-5 {source="cas"}
xref: gmelin:16221 {source="gmelin"}
xref: kegg.compound:C01330 {source="kegg.compound"}
xref: webelements:Na {source="webelements"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:22314 ! alkali metal atom
relationship: RO:0000087 CHEBI:33937 ! has role macronutrient
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
[Term]
id: CHEBI:26712
name: sodium molecular entity
subset: 3:STAR
synonym: "sodium compounds" RELATED [chebi]
synonym: "sodium molecular entities" RELATED [chebi]
is_a: CHEBI:33296 ! alkali metal molecular entity
relationship: has_part CHEBI:26708 ! sodium atom
[Term]
id: CHEBI:26714
name: sodium salt
def: "Any alkali metal salt having sodium(1+) as the cation." []
subset: 3:STAR
synonym: "Natriumsalz" RELATED [chebi]
synonym: "Natriumsalze" RELATED [chebi]
synonym: "sodium salts" RELATED [chebi]
is_a: CHEBI:26712 ! sodium molecular entity
is_a: CHEBI:35479 ! alkali metal salt
relationship: has_part CHEBI:29101 ! sodium(1+)
[Term]
id: CHEBI:26739
name: sphingolipid
def: "Sphingolipids are a complex family of compounds that share a common structural feature, a sphingoid base backbone." []
subset: 3:STAR
synonym: "sphingolipids" RELATED [chebi]
is_a: CHEBI:18059 ! lipid
is_a: CHEBI:35352 ! organonitrogen compound
is_a: CHEBI:36963 ! organooxygen compound
[Term]
id: CHEBI:26764
name: steroid hormone
def: "Any steroid that acts as hormone." []
subset: 3:STAR
synonym: "hormona esteroide" RELATED [chebi]
synonym: "hormonas esteroideas" RELATED [chebi]
synonym: "hormone steroide" RELATED [chebi]
synonym: "hormones steroides" RELATED [chebi]
synonym: "steroid hormones" RELATED [chebi]
synonym: "Steroidhormon" RELATED [chebi]
synonym: "Steroidhormone" RELATED [chebi]
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:35341 ! steroid
relationship: RO:0000087 CHEBI:24621 ! has role hormone
[Term]
id: CHEBI:26816
name: carbohydrate phosphate
subset: 3:STAR
synonym: "carbohydrate phosphates" RELATED [chebi]
is_a: CHEBI:25703 ! organic phosphate
is_a: CHEBI:37734 ! phosphoric ester
is_a: CHEBI:63299 ! carbohydrate derivative
[Term]
id: CHEBI:26819
name: sulfuric ester
def: "An ester of an alcohol and sulfuric acid." []
subset: 3:STAR
synonym: "sulfate ester" RELATED [chebi]
synonym: "sulfuric acid ester" RELATED [chebi]
synonym: "sulfuric acid esters" RELATED [chebi]
is_a: CHEBI:35701 ! ester
is_a: CHEBI:37826 ! sulfuric acid derivative
[Term]
id: CHEBI:26820
name: sulfates
def: "Salts and esters of sulfuric acid" []
subset: 3:STAR
synonym: "sulfates" RELATED [chebi]
synonym: "sulfuric acid derivative" RELATED [chebi]
synonym: "sulphates" RELATED [chebi]
is_a: CHEBI:37826 ! sulfuric acid derivative
[Term]
id: CHEBI:26833
name: sulfur atom
subset: 3:STAR
synonym: "16S" RELATED [iupac]
synonym: "azufre" RELATED [chebi]
synonym: "Elemental sulfur" RELATED [kegg.compound]
synonym: "S" RELATED [iupac, kegg.compound]
synonym: "Schwefel" RELATED [chebi]
synonym: "soufre" RELATED [chebi]
synonym: "sulfur" EXACT IUPAC:NAME [IUPAC]
synonym: "sulfur" RELATED IUPAC:NAME [chebi, iupac, uniprot_ft]
synonym: "sulphur" RELATED [chebi]
synonym: "theion" RELATED [iupac]
xref: cas:7704-34-9 {source="cas"}
xref: kegg.compound:C00087 {source="kegg.compound"}
xref: kegg.drug:D06527 {source="kegg.drug"}
xref: ppdb:605 {source="ppdb"}
xref: webelements:S {source="webelements"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33303 ! chalcogen
relationship: RO:0000087 CHEBI:33937 ! has role macronutrient
[Term]
id: CHEBI:26835
name: sulfur molecular entity
subset: 3:STAR
synonym: "sulfur molecular entities" RELATED [chebi]
synonym: "sulfur molecular entity" RELATED [chebi]
is_a: CHEBI:33304 ! chalcogen molecular entity
relationship: has_part CHEBI:26833 ! sulfur atom
[Term]
id: CHEBI:26836
name: sulfuric acid
def: "A sulfur oxoacid that consists of two oxo and two hydroxy groups joined covalently to a central sulfur atom." []
subset: 3:STAR
synonym: "[S(OH)2O2]" RELATED [molbase]
synonym: "[SO2(OH)2]" RELATED [iupac]
synonym: "Acide sulfurique" RELATED [chemidplus]
synonym: "Acido sulfurico" RELATED [chemidplus]
synonym: "Acidum sulfuricum" RELATED [chemidplus]
synonym: "dihydrogen tetraoxosulfate" EXACT IUPAC:NAME [IUPAC]
synonym: "dihydrogen tetraoxosulfate" RELATED IUPAC:NAME [iupac]
synonym: "dihydroxidodioxidosulfur" EXACT IUPAC:NAME [IUPAC]
synonym: "dihydroxidodioxidosulfur" RELATED IUPAC:NAME [iupac]
synonym: "H2SO4" RELATED [iupac]
synonym: "hydrogen tetraoxosulfate(2-)" EXACT IUPAC:NAME [IUPAC]
synonym: "hydrogen tetraoxosulfate(2-)" RELATED IUPAC:NAME [iupac]
synonym: "hydrogen tetraoxosulfate(VI)" EXACT IUPAC:NAME [IUPAC]
synonym: "hydrogen tetraoxosulfate(VI)" RELATED IUPAC:NAME [iupac]
synonym: "Schwefelsaeureloesungen" RELATED [chemidplus]
synonym: "Sulfuric acid" RELATED [kegg.compound]
synonym: "sulfuric acid" EXACT IUPAC:NAME [IUPAC]
synonym: "sulfuric acid" RELATED IUPAC:NAME [chebi, iupac]
synonym: "sulphuric acid" RELATED [molbase]
synonym: "tetraoxosulfuric acid" EXACT IUPAC:NAME [IUPAC]
synonym: "tetraoxosulfuric acid" RELATED IUPAC:NAME [iupac]
xref: cas:7664-93-9 {source="cas"}
xref: gmelin:2122 {source="gmelin"}
xref: kegg.compound:C00059 {source="kegg.compound"}
xref: kegg.drug:D05963 {source="kegg.drug"}
xref: knapsack:C00007530 {source="knapsack"}
xref: molbase:4 {source="molbase"}
xref: ppdb:606 {source="ppdb"}
xref: pubmed:13568755 {source="pubmed"}
xref: pubmed:16122922 {source="pubmed"}
xref: pubmed:19397353 {source="pubmed"}
xref: pubmed:22047659 {source="pubmed"}
xref: pubmed:22136045 {source="pubmed"}
xref: pubmed:22204399 {source="pubmed"}
xref: pubmed:22267186 {source="pubmed"}
xref: pubmed:22296037 {source="pubmed"}
xref: pubmed:22364556 {source="pubmed"}
xref: pubmed:22435616 {source="pubmed"}
xref: reaxys:2037554 {source="reaxys"}
xref: wikipedia.en:Sulfuric_acid {source="wikipedia.en"}
is_a: CHEBI:33402 ! sulfur oxoacid
relationship: RO:0000087 CHEBI:35223 ! has role catalyst
relationship: RO:0018034 CHEBI:45696 ! is protonated form of hydrogensulfate
[Term]
id: CHEBI:26873
name: terpenoid
def: "Any isoprenoid that is a natural product or related compound formally derived from isoprene units. Terpenoids may contain oxygen in various functional groups. This class is subdivided according to the number of carbon atoms in the parent terpene. The skeleton of terpenoids may differ from strict additivity of isoprene units by the loss or shift of a fragment, generally a methyl group." []
subset: 3:STAR
synonym: "Terpenoid" RELATED [chebi]
synonym: "terpenoide" RELATED [iupac]
synonym: "terpenoides" RELATED [iupac]
synonym: "terpenoids" EXACT IUPAC:NAME [IUPAC]
synonym: "terpenoids" RELATED IUPAC:NAME [iupac]
xref: wikipedia.en:Terpenoid {source="wikipedia.en"}
is_a: CHEBI:24913 ! isoprenoid
relationship: RO:0018040 CHEBI:35186 ! has parent hydride terpene
[Term]
id: CHEBI:26912
name: oxolanes
def: "Any oxacycle having an oxolane (tetrahydrofuran) skeleton." []
subset: 3:STAR
is_a: CHEBI:25693 ! organic heteromonocyclic compound
is_a: CHEBI:38104 ! oxacycle
[Term]
id: CHEBI:26932
name: tetrapyrrole
def: "A natural pigment containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." []
subset: 3:STAR
synonym: "a tetrapyrrole" RELATED [uniprot_ft]
synonym: "tetrapyrrole" EXACT IUPAC:NAME [IUPAC]
synonym: "tetrapyrrole" RELATED IUPAC:NAME [iupac]
synonym: "tetrapyrroles" EXACT IUPAC:NAME [IUPAC]
synonym: "tetrapyrroles" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:33833 ! heteroarene
is_a: CHEBI:38077 ! polypyrrole
[Term]
id: CHEBI:26935
name: tetraterpenoid
def: "Any terpenoid derived from a tetraterpene. The term includes compounds in which the C40 skeleton of the parent tetraterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups)." []
subset: 3:STAR
synonym: "C40 isoprenoids" RELATED [lipidmaps]
synonym: "tetraterpenoides" RELATED [chebi]
synonym: "tetraterpenoids" EXACT IUPAC:NAME [IUPAC]
synonym: "tetraterpenoids" RELATED IUPAC:NAME [iupac]
xref: lipidmaps_class:LMPR0107 {source="lipidmaps_class"}
is_a: CHEBI:26873 ! terpenoid
relationship: RO:0018040 CHEBI:35193 ! has parent hydride tetraterpene
[Term]
id: CHEBI:27024
name: toluenes
def: "Any member of the class of benzenes that is a substituted benzene in which the substituents include one (and only one) methyl group." []
subset: 3:STAR
is_a: CHEBI:22712 ! benzenes
[Term]
id: CHEBI:27027
name: micronutrient
def: "Any nutrient required in small quantities by organisms throughout their life in order to orchestrate a range of physiological functions." []
subset: 3:STAR
synonym: "micronutrients" RELATED [chebi]
synonym: "trace elements" RELATED [chebi]
xref: wikipedia.en:Micronutrient {source="wikipedia.en"}
is_a: CHEBI:33284 ! nutrient
[Term]
id: CHEBI:27081
name: transition element atom
def: "An element whose atom has an incomplete d sub-shell, or which can give rise to cations with an incomplete d sub-shell." []
subset: 3:STAR
synonym: "metal de transicion" RELATED [chebi]
synonym: "metal de transition" RELATED [chebi]
synonym: "metales de transicion" RELATED [chebi]
synonym: "metaux de transition" RELATED [chebi]
synonym: "transition element" EXACT IUPAC:NAME [IUPAC]
synonym: "transition element" RELATED IUPAC:NAME [chebi, iupac]
synonym: "transition elements" RELATED [chebi]
synonym: "transition metal" RELATED [chebi]
synonym: "transition metals" RELATED [chebi]
synonym: "Uebergangselement" RELATED [chebi]
synonym: "Uebergangsmetalle" RELATED [chebi]
is_a: CHEBI:33521 ! metal atom
[Term]
id: CHEBI:27162
name: tryptamines
def: "Tryptamine and its substitution derivatives." []
subset: 3:STAR
is_a: CHEBI:24828 ! indoles
[Term]
id: CHEBI:27171
name: organic heterobicyclic compound
subset: 3:STAR
synonym: "heterobicyclic compounds" RELATED [chebi]
synonym: "organic heterobicyclic compounds" RELATED [chebi]
is_a: CHEBI:33672 ! heterobicyclic compound
is_a: CHEBI:38166 ! organic heteropolycyclic compound
[Term]
id: CHEBI:27177
name: L-tyrosine derivative
def: "A proteinogenic amino acid derivative resulting from reaction of L-tyrosine at the amino group or the carboxy group, or from the replacement of any hydrogen of L-tyrosine by a heteroatom." []
subset: 3:STAR
synonym: "L-tyrosine derivatives" RELATED [chebi]
is_a: CHEBI:62761 ! tyrosine derivative
is_a: CHEBI:84144 ! L-phenylalanine derivative
relationship: RO:0018038 CHEBI:17895 ! has functional parent L-tyrosine
[Term]
id: CHEBI:27207
name: univalent carboacyl group
def: "A univalent carboacyl group is a group formed by loss of OH from the carboxy group of a carboxylic acid." []
subset: 3:STAR
synonym: "univalent acyl group" RELATED [chebi]
synonym: "univalent carboacyl groups" RELATED [chebi]
synonym: "univalent carboxylic acyl groups" RELATED [chebi]
is_a: CHEBI:37838 ! carboacyl group
[Term]
id: CHEBI:27325
name: xanthophyll
def: "A subclass of carotenoids consisting of the oxygenated carotenes." []
subset: 3:STAR
synonym: "xanthophylls" EXACT IUPAC:NAME [IUPAC]
synonym: "xanthophylls" RELATED IUPAC:NAME [chebi, iupac]
xref: drugbank:DB00137 {source="drugbank"}
is_a: CHEBI:23044 ! carotenoid
[Term]
id: CHEBI:27369
name: zwitterion
def: "A neutral compound having formal unit electrical charges of opposite sign on non-adjacent atoms. Sometimes referred to as inner salts, dipolar ions (a misnomer)." []
subset: 3:STAR
synonym: "compose zwitterionique" RELATED [iupac]
synonym: "compuestos zwitterionicos" RELATED [iupac]
synonym: "zwitterion" EXACT IUPAC:NAME [IUPAC]
synonym: "zwitterion" RELATED IUPAC:NAME [iupac]
synonym: "zwitteriones" RELATED [iupac]
synonym: "zwitterionic compounds" RELATED [iupac]
synonym: "zwitterions" EXACT IUPAC:NAME [IUPAC]
synonym: "zwitterions" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:51151 ! dipolar compound
[Term]
id: CHEBI:27547
name: zeaxanthin
alt_id: CHEBI:10108
alt_id: CHEBI:27361
subset: 3:STAR
synonym: "(3R,3'R)-beta,beta-carotene-3,3'-diol" EXACT IUPAC:NAME [IUPAC]
synonym: "(3R,3'R)-beta,beta-carotene-3,3'-diol" RELATED IUPAC:NAME [iupac]
synonym: "(3R,3'R)-dihydroxy-beta,beta-carotene" RELATED [chebi]
synonym: "all-trans-beta-carotene-3,3'-diol" RELATED [chebi]
synonym: "all-trans-zeaxanthin" RELATED [uniprot_ft]
synonym: "anchovyxanthin" RELATED [chebi]
synonym: "beta,beta-carotene-3,3'-diol" RELATED [chebi]
synonym: "Zeaxanthin" RELATED [kegg.compound]
xref: beilstein:2068416 {source="beilstein"}
xref: cas:144-68-3 {source="cas"}
xref: kegg.compound:C06098 {source="kegg.compound"}
xref: knapsack:C00000931 {source="knapsack"}
xref: lipidmaps:LMPR01070261 {source="lipidmaps"}
xref: metacyc.compound:CPD1F-130 {source="metacyc.compound"}
xref: wikipedia.en:Zeaxanthin {source="wikipedia.en"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:23045 ! carotenol
relationship: RO:0000087 CHEBI:22586 ! has role antioxidant
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite
relationship: RO:0018040 CHEBI:17579 ! has parent hydride beta-carotene
[Term]
id: CHEBI:27584
name: aldosterone
alt_id: CHEBI:22306
alt_id: CHEBI:2563
alt_id: CHEBI:40919
def: "A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney." []
subset: 3:STAR
synonym: "(+)-aldosterone" RELATED [nist]
synonym: "(11beta)-11,21-dihydroxy-3,20-dioxopregn-4-en-18-al" RELATED [nist]
synonym: "11beta,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al" RELATED [kegg.compound]
synonym: "11beta,21-dihydroxy-3,20-dioxopregn-4-en-18-al" EXACT IUPAC:NAME [IUPAC]
synonym: "11beta,21-dihydroxy-3,20-dioxopregn-4-en-18-al" RELATED IUPAC:NAME [iupac]
synonym: "ALDOSTERONE" RELATED [pdb-ccd]
synonym: "Aldosterone" RELATED [kegg.compound]
synonym: "aldosterone" RELATED [uniprot_ft]
xref: cas:52-39-1 {source="cas"}
xref: drugbank:DB04630 {source="drugbank"}
xref: drugcentral:111 {source="drugcentral"}
xref: hmdb:HMDB0000037 {source="hmdb"}
xref: kegg.compound:C01780 {source="kegg.compound"}
xref: lincs.smallmolecule:LSM-42770 {source="lincs.smallmolecule"}
xref: lipidmaps:LMST02030026 {source="lipidmaps"}
xref: pdb-ccd:AS4 {source="pdb-ccd"}
xref: pubmed:10438974 {source="pubmed"}
xref: reaxys:3224996 {source="reaxys"}
xref: wikipedia.en:Aldosterone {source="wikipedia.en"}
is_a: CHEBI:131565 ! steroid aldehyde
is_a: CHEBI:139590 ! primary alpha-hydroxy ketone
is_a: CHEBI:25354 ! mineralocorticoid
is_a: CHEBI:35344 ! 21-hydroxy steroid
is_a: CHEBI:35346 ! 11beta-hydroxy steroid
is_a: CHEBI:36885 ! 20-oxo steroid
is_a: CHEBI:36887 ! 18-oxo steroid
is_a: CHEBI:47909 ! 3-oxo-Delta(4) steroid
is_a: CHEBI:64600 ! C21-steroid hormone
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018040 CHEBI:8386 ! has parent hydride pregnane
[Term]
id: CHEBI:27594
name: carbon atom
alt_id: CHEBI:23009
alt_id: CHEBI:3399
subset: 3:STAR
synonym: "6C" RELATED [iupac]
synonym: "C" RELATED [iupac, kegg.compound]
synonym: "Carbon" EXACT [KEGG_COMPOUND]
synonym: "Carbon" RELATED [kegg.compound]
synonym: "carbon" EXACT IUPAC:NAME [IUPAC]
synonym: "carbon" RELATED IUPAC:NAME [chebi, iupac]
synonym: "carbone" RELATED [chebi]
synonym: "carbonium" RELATED [chebi]
synonym: "carbono" RELATED [chebi]
synonym: "Kohlenstoff" RELATED [chebi]
xref: cas:7440-44-0 {source="cas"}
xref: kegg.compound:C06265 {source="kegg.compound"}
xref: webelements:C {source="webelements"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33306 ! carbon group element atom
relationship: RO:0000087 CHEBI:33937 ! has role macronutrient
[Term]
id: CHEBI:28017
name: starch
alt_id: CHEBI:26750
alt_id: CHEBI:26751
alt_id: CHEBI:9251
def: "The most important reserve polysaccharide found in plants. It is a glucan consisting of amylose and amylopectin." []
subset: 3:STAR
synonym: "amidon" RELATED [chebi]
synonym: "amylum" RELATED [chebi]
synonym: "Staerke" RELATED [chebi]
synonym: "Starch" RELATED [kegg.compound]
xref: cas:9005-25-8 {source="cas"}
xref: kegg.compound:C00369 {source="kegg.compound"}
xref: kegg.drug:D06507 {source="kegg.drug"}
xref: kegg.glycan:G10545 {source="kegg.glycan"}
xref: wikipedia.en:Starch {source="wikipedia.en"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:37163 ! glucan
relationship: has_part CHEBI:28057 ! amylopectin
relationship: has_part CHEBI:28102 ! amylose
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
[Term]
id: CHEBI:28044
name: phenylalanine
alt_id: CHEBI:25984
alt_id: CHEBI:8089
def: "An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group." []
subset: 3:STAR
synonym: "2-amino-3-phenylpropanoic acid" EXACT IUPAC:NAME [IUPAC]
synonym: "2-amino-3-phenylpropanoic acid" RELATED IUPAC:NAME [iupac]
synonym: "alpha-Amino-beta-phenylpropionic acid" RELATED [kegg.compound]
synonym: "DL-Phenylalanine" RELATED [kegg.compound]
synonym: "F" RELATED [chebi]
synonym: "fenilalanina" RELATED [chebi]
synonym: "PHE" RELATED [chebi]
synonym: "Phenylalanin" RELATED [chebi]
synonym: "Phenylalanine" EXACT [KEGG_COMPOUND]
synonym: "Phenylalanine" RELATED [kegg.compound]
synonym: "phenylalanine" EXACT IUPAC:NAME [IUPAC]
synonym: "phenylalanine" RELATED IUPAC:NAME [chebi, iupac]
xref: cas:150-30-1 {source="cas"}
xref: gmelin:50836 {source="gmelin"}
xref: kegg.compound:C02057 {source="kegg.compound"}
xref: pubmed:17439666 {source="pubmed"}
xref: pubmed:22264337 {source="pubmed"}
xref: reaxys:1910407 {source="reaxys"}
xref: wikipedia.en:Phenylalanine {source="wikipedia.en"}
is_a: CHEBI:33704 ! alpha-amino acid
is_a: CHEBI:33856 ! aromatic amino acid
relationship: has_part CHEBI:22744 ! benzyl group
relationship: RO:0000087 CHEBI:83056 ! has role Daphnia magna metabolite
relationship: RO:0018033 CHEBI:32505 ! is deprotonated form of phenylalaninium
relationship: RO:0018034 CHEBI:32504 ! is protonated form of phenylalaninate
[Term]
id: CHEBI:28057
name: amylopectin
alt_id: CHEBI:22538
alt_id: CHEBI:2693
def: "A polydisperse highly branched polysaccharide derivative composed of chains of D-glucopyranose residues in α(1→4) glycosidic linkage. The chains are joined together by α(1→6) glycosidic linkages. A small number of α(1→3) glycosidic linkages and some 6-phosphate ester groups also may occur. The branches in amylopectin typically contain 24 to 30 glucose residues." []
subset: 3:STAR
synonym: "Amylopectin" RELATED [kegg.compound]
xref: cas:9037-22-3 {source="cas"}
xref: kegg.compound:C00317 {source="kegg.compound"}
is_a: CHEBI:65212 ! polysaccharide derivative
[Term]
id: CHEBI:28087
name: glycogen
alt_id: CHEBI:24379
alt_id: CHEBI:5466
def: "A polydisperse, highly branched glucan composed of chains of D-glucopyranose residues in α(1→4) glycosidic linkage, joined together by α(1→6) glycosidic linkages. A small number of α(1→3) glycosidic linkages and some cumulative α(1→6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues." []
subset: 3:STAR
synonym: "animal starch" RELATED [chemidplus]
synonym: "Glycogen" RELATED [kegg.compound]
synonym: "liver starch" RELATED [chemidplus]
xref: cas:9005-79-2 {source="cas"}
xref: glygen:G99991IU {source="glygen"}
xref: glytoucan:G99991IU {source="glytoucan"}
xref: hmdb:HMDB0000757 {source="hmdb"}
xref: kegg.compound:C00182 {source="kegg.compound"}
xref: metacyc.compound:CPD0-971 {source="metacyc.compound"}
xref: wikipedia.en:Glycogen {source="wikipedia.en"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:24384 ! glycogens
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
[Term]
id: CHEBI:28102
name: amylose
alt_id: CHEBI:22539
alt_id: CHEBI:2694
def: "A glucan composed of unbranched chains of D-glucopyranose residues in α(1→4) glycosidic linkage. The number of repeated glucose subunits (n) is usually in the range of 300 to 3000, but can be many thousands. One of the two components of starch (the other, 70-80%, being amylopectin). Cf. linear maltodextrin, in which the chain length is typically between 3 and 17 glucose units." []
subset: 3:STAR
synonym: "(1,4-alpha-D-Glucosyl)n" RELATED [kegg.compound]
synonym: "(1,4-alpha-D-Glucosyl)n+1" RELATED [kegg.compound]
synonym: "(1,4-alpha-D-Glucosyl)n-1" RELATED [kegg.compound]
synonym: "(1->4)-alpha-D-glucopyranan" EXACT IUPAC:NAME [IUPAC]
synonym: "(1->4)-alpha-D-glucopyranan" RELATED IUPAC:NAME [iupac]
synonym: "1,4-alpha-D-Glucan" RELATED [kegg.compound]
synonym: "4-{(1,4)-alpha-D-Glucosyl}(n-1)-D-glucose" RELATED [kegg.compound]
synonym: "Amylose" RELATED [kegg.compound]
synonym: "Amylose chain" RELATED [kegg.compound]
xref: cas:9005-82-7 {source="cas"}
xref: hmdb:HMDB0003403 {source="hmdb"}
xref: kegg.compound:C00718 {source="kegg.compound"}
xref: kegg.drug:D02329 {source="kegg.drug"}
xref: kegg.glycan:G10495 {source="kegg.glycan"}
xref: pubmed:24162153 {source="pubmed"}
xref: pubmed:24299760 {source="pubmed"}
xref: pubmed:24491702 {source="pubmed"}
xref: pubmed:24505384 {source="pubmed"}
xref: reaxys:8194785 {source="reaxys"}
xref: wikipedia.en:Amylose {source="wikipedia.en"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:37163 ! glucan
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
[Term]
id: CHEBI:28425
name: alpha-carotene
alt_id: CHEBI:10215
alt_id: CHEBI:22447
def: "A cyclic carotene with a β- and an ε-ring at opposite ends respectively." []
subset: 3:STAR
synonym: "all-trans-alpha-carotene" RELATED [chemidplus]
synonym: "Alpha-carotene" RELATED [uniprot_ft]
synonym: "alpha-Carotene" RELATED [kegg.compound]
synonym: "beta,epsilon-carotene" EXACT IUPAC:NAME [IUPAC]
synonym: "beta,epsilon-carotene" RELATED IUPAC:NAME [iupac]
xref: beilstein:2067408 {source="beilstein"}
xref: beilstein:3227599 {source="beilstein"}
xref: cas:432-70-2 {source="cas"}
xref: hmdb:HMDB0003993 {source="hmdb"}
xref: kegg.compound:C05433 {source="kegg.compound"}
xref: knapsack:C00003765 {source="knapsack"}
xref: lipidmaps:LMPR01070258 {source="lipidmaps"}
xref: pubmed:23620017 {source="pubmed"}
xref: pubmed:24169341 {source="pubmed"}
xref: pubmed:9408998 {source="pubmed"}
xref: reaxys:2682045 {source="reaxys"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:139120 ! carotenoid beta-end derivative
is_a: CHEBI:35163 ! cyclic carotene
relationship: RO:0000087 CHEBI:67200 ! has role provitamin A
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
[Term]
id: CHEBI:28479
name: D-tyrosine
alt_id: CHEBI:21111
alt_id: CHEBI:42299
alt_id: CHEBI:4258
def: "An optically active form of tyrosine having D-configuration." []
subset: 3:STAR
synonym: "(2R)-2-amino-3-(4-hydroxyphenyl)propanoic acid" RELATED [iupac]
synonym: "(R)-2-Amino-3-(p-hydroxyphenyl)propionic acid" RELATED [kegg.compound]
synonym: "(R)-3-(p-Hydroxyphenyl)alanine" RELATED [kegg.compound]
synonym: "D-Tyr" RELATED [chebi]
synonym: "D-Tyrosin" RELATED [chebi]
synonym: "D-TYROSINE" EXACT [PDBeChem]
synonym: "D-TYROSINE" RELATED [pdb-ccd]
synonym: "D-Tyrosine" EXACT [KEGG_COMPOUND]
synonym: "D-Tyrosine" RELATED [kegg.compound]
synonym: "D-tyrosine" EXACT IUPAC:NAME [IUPAC]
synonym: "D-tyrosine" RELATED IUPAC:NAME [iupac]
synonym: "DTY" RELATED [pdb-ccd]
xref: cas:556-02-5 {source="cas"}
xref: drugbank:DB03839 {source="drugbank"}
xref: ecmdb:ECMDB21520 {source="ecmdb"}
xref: gmelin:603524 {source="gmelin"}
xref: kegg.compound:C06420 {source="kegg.compound"}
xref: metacyc.compound:D-TYROSINE {source="metacyc.compound"}
xref: pdb-ccd:DTY {source="pdb-ccd"}
xref: pubmed:15292242 {source="pubmed"}
xref: pubmed:23381872 {source="pubmed"}
xref: pubmed:24936396 {source="pubmed"}
xref: reaxys:2212157 {source="reaxys"}
xref: ymdb:YMDB00805 {source="ymdb"}
is_a: CHEBI:16733 ! D-alpha-amino acid
is_a: CHEBI:18186 ! tyrosine
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0018033 CHEBI:32775 ! is deprotonated form of D-tyrosinium
relationship: RO:0018034 CHEBI:32773 ! is protonated form of D-tyrosinate(1-)
relationship: RO:0018036 CHEBI:58570 ! is tautomer of D-tyrosine zwitterion
relationship: RO:0018039 CHEBI:17895 ! is enantiomer of L-tyrosine
[Term]
id: CHEBI:28616
name: carbamic acid
alt_id: CHEBI:22504
alt_id: CHEBI:23002
alt_id: CHEBI:3386
alt_id: CHEBI:44573
def: "A one-carbon compound that is ammonia in which one of the hydrogens is replaced by a carboxy group. Although carbamic acid derivatives are common, carbamic acid itself has never been synthesised." []
subset: 3:STAR
synonym: "Aminoameisensaeure" RELATED [chebi]
synonym: "Aminoformic acid" RELATED [kegg.compound]
synonym: "Carbamate" EXACT [KEGG_COMPOUND]
synonym: "Carbamate" RELATED [kegg.compound]
synonym: "CARBAMIC ACID" EXACT [PDBeChem]
synonym: "CARBAMIC ACID" RELATED [pdb-ccd]
synonym: "Carbamic acid" EXACT [KEGG_COMPOUND]
synonym: "Carbamic acid" RELATED [kegg.compound]
synonym: "carbamic acid" EXACT IUPAC:NAME [IUPAC]
synonym: "carbamic acid" RELATED IUPAC:NAME [iupac]
synonym: "Carbamidsaeure" RELATED [chebi]
xref: beilstein:1734754 {source="beilstein"}
xref: cas:463-77-4 {source="cas"}
xref: drugbank:DB04261 {source="drugbank"}
xref: gmelin:130345 {source="gmelin"}
xref: kegg.compound:C01563 {source="kegg.compound"}
xref: pdb-ccd:OUT {source="pdb-ccd"}
xref: wikipedia.en:Carbamic_acid {source="wikipedia.en"}
is_a: CHEBI:35352 ! organonitrogen compound
is_a: CHEBI:35605 ! carbon oxoacid
is_a: CHEBI:64708 ! one-carbon compound
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0018034 CHEBI:13941 ! is protonated form of carbamate
[Term]
id: CHEBI:28659
name: phosphorus atom
alt_id: CHEBI:26080
alt_id: CHEBI:8168
subset: 3:STAR
synonym: "15P" RELATED [iupac]
synonym: "fosforo" RELATED [chebi]
synonym: "P" RELATED [iupac, kegg.compound]
synonym: "Phosphor" RELATED [chebi]
synonym: "phosphore" RELATED [chebi]
synonym: "Phosphorus" EXACT [KEGG_COMPOUND]
synonym: "Phosphorus" RELATED [kegg.compound]
synonym: "phosphorus" EXACT IUPAC:NAME [IUPAC]
synonym: "phosphorus" RELATED IUPAC:NAME [chebi, iupac]
xref: cas:7723-14-0 {source="cas"}
xref: gmelin:16235 {source="gmelin"}
xref: kegg.compound:C06262 {source="kegg.compound"}
xref: webelements:P {source="webelements"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33300 ! pnictogen
relationship: RO:0000087 CHEBI:33937 ! has role macronutrient
[Term]
id: CHEBI:28790
name: serotonin
alt_id: CHEBI:1420
alt_id: CHEBI:26652
alt_id: CHEBI:49894
def: "A primary amino compound that is the 5-hydroxy derivative of tryptamine." []
subset: 3:STAR
synonym: "3-(2-Aminoethyl)-1H-indol-5-ol" EXACT [KEGG_COMPOUND]
synonym: "3-(2-Aminoethyl)-1H-indol-5-ol" RELATED [kegg.compound]
synonym: "3-(2-aminoethyl)-1H-indol-5-ol" EXACT IUPAC:NAME [IUPAC]
synonym: "3-(2-aminoethyl)-1H-indol-5-ol" RELATED IUPAC:NAME [iupac]
synonym: "5-HT" RELATED [iuphar]
synonym: "5-Hydroxytryptamine" RELATED [kegg.compound]
synonym: "Enteramine" RELATED [kegg.compound]
synonym: "SEROTONIN" RELATED [pdb-ccd]
synonym: "Serotonin" RELATED [kegg.compound]
synonym: "serotonine" RELATED [chebi]
synonym: "thrombocytin" RELATED [chemidplus]
synonym: "thrombotonin" RELATED [chemidplus]
xref: cas:50-67-9 {source="cas"}
xref: gmelin:1861995 {source="gmelin"}
xref: hmdb:HMDB0000259 {source="hmdb"}
xref: kegg.compound:C00780 {source="kegg.compound"}
xref: knapsack:C00001429 {source="knapsack"}
xref: lincs.smallmolecule:LSM-6589 {source="lincs.smallmolecule"}
xref: metacyc.compound:SEROTONIN {source="metacyc.compound"}
xref: pdb-ccd:SRO {source="pdb-ccd"}
xref: pubmed:18593914 {source="pubmed"}
xref: pubmed:22770225 {source="pubmed"}
xref: pubmed:24136337 {source="pubmed"}
xref: reaxys:143524 {source="reaxys"}
xref: wikipedia.en:Serotonin {source="wikipedia.en"}
is_a: CHEBI:25375 ! monoamine molecular messenger
is_a: CHEBI:27162 ! tryptamines
is_a: CHEBI:33853 ! phenols
is_a: CHEBI:50994 ! primary amino compound
is_a: CHEBI:84729 ! hydroxyindoles
relationship: RO:0000087 CHEBI:25512 ! has role neurotransmitter
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018033 CHEBI:350546 ! is deprotonated form of serotonin(1+)
relationship: RO:0018038 CHEBI:16765 ! has functional parent tryptamine
[Term]
id: CHEBI:28793
name: beta-D-glucan
alt_id: CHEBI:10394
alt_id: CHEBI:22793
subset: 3:STAR
synonym: "beta-D-Glucan" RELATED [kegg.compound]
synonym: "beta-D-glucans" RELATED [chebi]
synonym: "beta-Glucan" RELATED [kegg.compound]
xref: cas:9041-22-9 {source="cas"}
xref: kegg.compound:C00551 {source="kegg.compound"}
is_a: CHEBI:37163 ! glucan
[Term]
id: CHEBI:28838
name: lutein
alt_id: CHEBI:27324
alt_id: CHEBI:43817
alt_id: CHEBI:6576
subset: 3:STAR
synonym: "(3R,3'R,6'R)-beta,epsilon-carotene-3,3'-diol" EXACT IUPAC:NAME [IUPAC]
synonym: "(3R,3'R,6'R)-beta,epsilon-carotene-3,3'-diol" RELATED IUPAC:NAME [iupac]
synonym: "(3R,3'R,6S)-4,5-DIDEHYDRO-5,6-DIHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL" RELATED [pdb-ccd]
synonym: "Bo-Xan" RELATED [chemidplus]
synonym: "E 161b" RELATED [chebi]
synonym: "Lutein" RELATED [kegg.compound]
synonym: "lutein" RELATED [uniprot_ft]
synonym: "Xanthophyll" RELATED [kegg.compound]
xref: cas:127-40-2 {source="cas"}
xref: drugbank:DB00137 {source="drugbank"}
xref: drugcentral:4145 {source="drugcentral"}
xref: hmdb:HMDB0003233 {source="hmdb"}
xref: kegg.compound:C08601 {source="kegg.compound"}
xref: knapsack:C00003776 {source="knapsack"}
xref: lipidmaps:LMPR01070274 {source="lipidmaps"}
xref: metacyc.compound:CPD1F-119 {source="metacyc.compound"}
xref: pdb-ccd:LUT {source="pdb-ccd"}
xref: pubmed:10714278 {source="pubmed"}
xref: pubmed:14670087 {source="pubmed"}
xref: pubmed:23543147 {source="pubmed"}
xref: pubmed:24451312 {source="pubmed"}
xref: reaxys:2068550 {source="reaxys"}
xref: wikipedia.en:Lutein {source="wikipedia.en"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:23045 ! carotenol
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
relationship: RO:0000087 CHEBI:77182 ! has role food colouring
relationship: RO:0018040 CHEBI:35147 ! has parent hydride (6'R)-beta,epsilon-carotene
[Term]
id: CHEBI:28868
name: fatty acid anion
alt_id: CHEBI:13634
alt_id: CHEBI:24022
alt_id: CHEBI:4985
def: "The conjugate base of a fatty acid, arising from deprotonation of the carboxylic acid group of the corresponding fatty acid." []
subset: 3:STAR
synonym: "a fatty acid" RELATED [uniprot_ft]
synonym: "acido graso anionico" RELATED [chebi]
synonym: "acidos grasos anionicos" RELATED [chebi]
synonym: "Alkanate" RELATED [kegg.compound]
synonym: "anion de l'acide gras" RELATED [chebi]
synonym: "Fatty acid anion" RELATED [kegg.compound]
synonym: "fatty acid anions" RELATED [chebi]
synonym: "Fettsaeureanion" RELATED [chebi]
synonym: "Fettsaeureanionen" RELATED [chebi]
xref: kegg.compound:C02403 {source="kegg.compound"}
xref: pubmed:18628202 {source="pubmed"}
is_a: CHEBI:18059 ! lipid
is_a: CHEBI:35757 ! monocarboxylic acid anion
relationship: RO:0018033 CHEBI:35366 ! is deprotonated form of fatty acid
[Term]
id: CHEBI:28918
name: (R)-adrenaline
alt_id: CHEBI:1942
alt_id: CHEBI:23928
def: "The R-enantiomer of adrenaline. It is a hormone secreted by the adrenal glands resulting in the 'fight-or-flight' response." []
subset: 3:STAR
synonym: "(-)-(R)-epinephrine" RELATED [chemidplus]
synonym: "(-)-3,4-dihydroxy-alpha-((methylamino)methyl)benzyl alcohol" RELATED [nist]
synonym: "(-)-adrenaline" RELATED [iuphar]
synonym: "(R)-(-)-Adnephrine" RELATED [kegg.compound]
synonym: "(R)-(-)-Adrenaline" RELATED [kegg.compound]
synonym: "(R)-(-)-adrenaline" RELATED [chebi]
synonym: "(R)-(-)-Epinephrine" RELATED [kegg.compound]
synonym: "(R)-(-)-Epirenamine" RELATED [kegg.compound]
synonym: "4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol" RELATED [kegg.compound]
synonym: "4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol" EXACT IUPAC:NAME [IUPAC]
synonym: "4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol" RELATED IUPAC:NAME [iupac]
synonym: "Adrenalin" RELATED BRAND:NAME [kegg.drug, nist]
synonym: "adrenaline" RELATED [chebi, nist]
synonym: "epinefrina" RELATED http://purl.obolibrary.org/obo/chebi/INN [chemidplus]
synonym: "Epinephrin" RELATED [chebi]
synonym: "epinephrine" RELATED http://purl.obolibrary.org/obo/chebi/INN [chebi, chemidplus]
synonym: "epinephrinum" RELATED http://purl.obolibrary.org/obo/chebi/INN [chemidplus]
synonym: "Epipen" RELATED BRAND:NAME [drugbank, kegg.drug]
synonym: "Epipen JR" RELATED BRAND:NAME [drugbank]
synonym: "L-Adrenaline" RELATED [kegg.compound]
synonym: "levoepinephrine" RELATED [iuphar]
synonym: "Primatene" RELATED BRAND:NAME [drugbank]
xref: cas:51-43-4 {source="cas"}
xref: drugbank:DB00668 {source="drugbank"}
xref: drugcentral:1028 {source="drugcentral"}
xref: hmdb:HMDB0000068 {source="hmdb"}
xref: kegg.compound:C00788 {source="kegg.compound"}
xref: kegg.drug:D00095 {source="kegg.drug"}
xref: knapsack:C00029643 {source="knapsack"}
xref: metacyc.compound:L-EPINEPHRINE {source="metacyc.compound"}
xref: pubmed:18325983 {source="pubmed"}
xref: pubmed:21963816 {source="pubmed"}
xref: pubmed:22115931 {source="pubmed"}
xref: pubmed:22405854 {source="pubmed"}
xref: pubmed:22425731 {source="pubmed"}
xref: pubmed:22429969 {source="pubmed"}
xref: pubmed:22569014 {source="pubmed"}
xref: pubmed:22623754 {source="pubmed"}
xref: pubmed:22826982 {source="pubmed"}
xref: pubmed:22895980 {source="pubmed"}
xref: pubmed:22898765 {source="pubmed"}
xref: pubmed:22905594 {source="pubmed"}
xref: pubmed:22940899 {source="pubmed"}
xref: pubmed:23066296 {source="pubmed"}
xref: pubmed:23130169 {source="pubmed"}
xref: pubmed:23164182 {source="pubmed"}
xref: pubmed:23185846 {source="pubmed"}
xref: pubmed:29438107 {source="pubmed"}
xref: reaxys:2368277 {source="reaxys"}
xref: wikipedia.en:Epinephrine {source="wikipedia.en"}
is_a: CHEBI:194548 ! 4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
relationship: RO:0000087 CHEBI:24621 ! has role hormone
relationship: RO:0000087 CHEBI:35522 ! has role beta-adrenergic agonist
relationship: RO:0000087 CHEBI:35523 ! has role bronchodilator agent
relationship: RO:0000087 CHEBI:35524 ! has role sympathomimetic agent
relationship: RO:0000087 CHEBI:35569 ! has role alpha-adrenergic agonist
relationship: RO:0000087 CHEBI:35620 ! has role vasodilator agent
relationship: RO:0000087 CHEBI:37886 ! has role adrenergic agonist
relationship: RO:0000087 CHEBI:50513 ! has role mydriatic agent
relationship: RO:0000087 CHEBI:50514 ! has role vasoconstrictor agent
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0018033 CHEBI:71406 ! is deprotonated form of (R)-adrenaline(1+)
relationship: RO:0018039 CHEBI:40751 ! is enantiomer of (S)-adrenaline
[Term]
id: CHEBI:28938
name: ammonium
alt_id: CHEBI:22534
alt_id: CHEBI:49783
alt_id: CHEBI:7435
def: "An onium cation obtained by protonation of ammonia." []
subset: 3:STAR
synonym: "[NH4](+)" RELATED [molbase]
synonym: "ammonium" EXACT IUPAC:NAME [ChEBI, IUPAC]
synonym: "ammonium" RELATED IUPAC:NAME [chebi, iupac]
synonym: "ammonium cation" RELATED [chemidplus]
synonym: "ammonium ion" RELATED [pdb-ccd]
synonym: "Ammonium(1+)" RELATED [chemidplus]
synonym: "azanium" EXACT IUPAC:NAME [IUPAC]
synonym: "azanium" RELATED IUPAC:NAME [iupac]
synonym: "NH(4)(+)" RELATED [uniprot_ft]
synonym: "NH4(+)" RELATED [iupac]
synonym: "NH4+" RELATED [kegg.compound]
xref: cas:14798-03-9 {source="cas"}
xref: gmelin:84 {source="gmelin"}
xref: kegg.compound:C01342 {source="kegg.compound"}
xref: metacyc.compound:AMMONIUM {source="metacyc.compound"}
xref: molbase:929 {source="molbase"}
xref: pdb-ccd:NH4 {source="pdb-ccd"}
xref: pubmed:11319011 {source="pubmed"}
xref: pubmed:11341317 {source="pubmed"}
xref: pubmed:12096804 {source="pubmed"}
xref: pubmed:14512268 {source="pubmed"}
xref: pubmed:14879753 {source="pubmed"}
xref: pubmed:16345391 {source="pubmed"}
xref: pubmed:16903292 {source="pubmed"}
xref: pubmed:17392693 {source="pubmed"}
xref: pubmed:18515490 {source="pubmed"}
xref: pubmed:19199063 {source="pubmed"}
xref: pubmed:19596600 {source="pubmed"}
xref: pubmed:19682559 {source="pubmed"}
xref: pubmed:19716251 {source="pubmed"}
xref: pubmed:21993530 {source="pubmed"}
xref: pubmed:22265469 {source="pubmed"}
xref: pubmed:22524020 {source="pubmed"}
xref: pubmed:22562341 {source="pubmed"}
xref: pubmed:22631217 {source="pubmed"}
xref: reaxys:16093784 {source="reaxys"}
xref: wikipedia.en:Ammonium {source="wikipedia.en"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:35106 ! nitrogen hydride
is_a: CHEBI:50313 ! onium cation
is_a: CHEBI:60242 ! monovalent inorganic cation
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018034 CHEBI:16134 ! is protonated form of ammonia
[Term]
id: CHEBI:28963
name: amino sugar
alt_id: CHEBI:22481
alt_id: CHEBI:22530
alt_id: CHEBI:2662
def: "Any sugar having one or more alcoholic hydroxy groups replaced by substituted or unsubstituted amino groups." []
subset: 3:STAR
synonym: "amino sugars" RELATED [chebi]
synonym: "aminosugar" RELATED [chebi]
synonym: "Aminosugars" RELATED [kegg.compound]
xref: kegg.compound:C05383 {source="kegg.compound"}
xref: pubmed:18424273 {source="pubmed"}
xref: pubmed:9056391 {source="pubmed"}
is_a: CHEBI:63299 ! carbohydrate derivative
[Term]
id: CHEBI:28965
name: dicarboxylic acid dianion
alt_id: CHEBI:13632
alt_id: CHEBI:23688
alt_id: CHEBI:23689
alt_id: CHEBI:38711
def: "A carboxylic acid dianion obtained by deprotonation of both carboxy groups of any dicarboxylic acid." []
subset: 3:STAR
synonym: "a dicarboxylate" RELATED [uniprot_ft]
synonym: "dicarboxylate" RELATED [chebi]
synonym: "dicarboxylates" RELATED [chebi]
synonym: "dicarboxylic acid dianion" RELATED [chebi]
synonym: "dicarboxylic acid dianions" RELATED [chebi]
is_a: CHEBI:35693 ! dicarboxylic acid anion
is_a: CHEBI:38716 ! carboxylic acid dianion
[Term]
id: CHEBI:28976
name: carbonic acid
alt_id: CHEBI:13351
alt_id: CHEBI:23017
alt_id: CHEBI:23744
alt_id: CHEBI:3401
subset: 3:STAR
synonym: "[CO(OH)2]" RELATED [iupac]
synonym: "Carbonic acid" EXACT [KEGG_COMPOUND]
synonym: "Carbonic acid" RELATED [kegg.compound]
synonym: "carbonic acid" EXACT IUPAC:NAME [IUPAC]
synonym: "carbonic acid" RELATED IUPAC:NAME [iupac]
synonym: "Dihydrogen carbonate" RELATED [kegg.compound]
synonym: "dihydroxidooxidocarbon" EXACT IUPAC:NAME [IUPAC]
synonym: "dihydroxidooxidocarbon" RELATED IUPAC:NAME [iupac]
synonym: "H2CO3" RELATED [iupac, kegg.compound]
synonym: "Koehlensaeure" RELATED [chebi]
xref: cas:463-79-6 {source="cas"}
xref: gmelin:25554 {source="gmelin"}
xref: kegg.compound:C01353 {source="kegg.compound"}
xref: pdb-ccd:CO3 {source="pdb-ccd"}
is_a: CHEBI:35605 ! carbon oxoacid
is_a: CHEBI:36961 ! chalcocarbonic acid
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0018034 CHEBI:17544 ! is protonated form of hydrogencarbonate
[Term]
id: CHEBI:29057
name: keratan
alt_id: CHEBI:14490
alt_id: CHEBI:24954
alt_id: CHEBI:89571
subset: 1:STAR
synonym: "keratan" RELATED [chebi]
synonym: "Keratan 6'-sulfate" RELATED [hmdb]
synonym: "Keratan 6'-sulphate" RELATED [hmdb]
synonym: "Keratan sulfate" RELATED [hmdb]
synonym: "Keratan sulphate" RELATED [hmdb]
synonym: "Kerato 6'-sulfate" RELATED [hmdb]
synonym: "Kerato 6'-sulphate" RELATED [hmdb]
synonym: "Kerato sulfate" RELATED [hmdb]
synonym: "Kerato sulphate" RELATED [hmdb]
synonym: "{[(2S,4S,5R,6S)-5-acetamido-6-{[(2S,3R,4S,5S,6R)-2-{[(2R,3S,4R,5R,6S)-5-acetamido-4-hydroxy-2-[(sulfooxy)methyl]-6-{[(2R,3R,4S,5S,6R)-2,3,5-trihydroxy-6-[(sulfooxy)methyl]oxan-4-yl]oxy}oxan-3-yl]oxy}-3,5-dihydroxy-6-[(sulfooxy)methyl]oxan-4-yl]oxy}-4-hydroxyoxan-2-yl]methoxy}sulfonic acid" RELATED [hmdb]
xref: cas:69992-87-6 {source="cas"}
xref: hmdb:HMDB0001165 {source="hmdb"}
xref: kegg.compound:C01431 {source="kegg.compound"}
xref: metacyc.compound:KERATAN {source="metacyc.compound"}
xref: pubmed:11514545 {source="pubmed"}
xref: pubmed:14711889 {source="pubmed"}
xref: pubmed:15042600 {source="pubmed"}
xref: pubmed:15082343 {source="pubmed"}
xref: pubmed:1633632 {source="pubmed"}
xref: pubmed:1710640 {source="pubmed"}
xref: pubmed:1718441 {source="pubmed"}
xref: pubmed:2056369 {source="pubmed"}
xref: pubmed:2100374 {source="pubmed"}
xref: pubmed:2521451 {source="pubmed"}
xref: pubmed:2562661 {source="pubmed"}
xref: pubmed:2935158 {source="pubmed"}
xref: pubmed:2951638 {source="pubmed"}
xref: pubmed:2952259 {source="pubmed"}
xref: pubmed:2957502 {source="pubmed"}
xref: pubmed:6242453 {source="pubmed"}
xref: pubmed:9054908 {source="pubmed"}
xref: pubmed:9208186 {source="pubmed"}
xref: pubmed:9313390 {source="pubmed"}
xref: pubmed:9397261 {source="pubmed"}
xref: wikipedia.en:keratan_sulfate {source="wikipedia.en"}
is_a: CHEBI:18085 ! glycosaminoglycan
[Term]
id: CHEBI:29067
name: carboxylic acid anion
alt_id: CHEBI:13626
alt_id: CHEBI:13945
alt_id: CHEBI:23026
alt_id: CHEBI:58657
def: "The conjugate base formed when the carboxy group of a carboxylic acid is deprotonated." []
subset: 3:STAR
synonym: "a carboxylate" RELATED [uniprot_ft]
synonym: "carboxylic acid anions" RELATED [chebi]
synonym: "carboxylic anions" RELATED [chebi]
is_a: CHEBI:25696 ! organic anion
is_a: CHEBI:35406 ! oxoanion
relationship: RO:0018033 CHEBI:33575 ! is deprotonated form of carboxylic acid
[Term]
id: CHEBI:29075
name: mononucleotide
alt_id: CHEBI:14616
alt_id: CHEBI:25404
alt_id: CHEBI:6983
subset: 3:STAR
synonym: "Mononucleotide" RELATED [kegg.compound]
synonym: "mononucleotides" RELATED [chebi]
xref: kegg.compound:C02171 {source="kegg.compound"}
is_a: CHEBI:36976 ! nucleotide
[Term]
id: CHEBI:29101
name: sodium(1+)
alt_id: CHEBI:26717
alt_id: CHEBI:49766
alt_id: CHEBI:9175
def: "A monoatomic monocation obtained from sodium." []
subset: 3:STAR
synonym: "Na(+)" RELATED [iupac, uniprot_ft]
synonym: "Na+" RELATED [kegg.compound]
synonym: "sodium cation" EXACT IUPAC:NAME [IUPAC]
synonym: "sodium cation" RELATED IUPAC:NAME [iupac]
synonym: "SODIUM ION" RELATED [pdb-ccd]
synonym: "sodium(1+)" EXACT IUPAC:NAME [IUPAC]
synonym: "sodium(1+)" RELATED IUPAC:NAME [iupac]
synonym: "sodium(1+) ion" EXACT IUPAC:NAME [IUPAC]
synonym: "sodium(1+) ion" RELATED IUPAC:NAME [iupac]
synonym: "sodium(I) cation" EXACT IUPAC:NAME [IUPAC]
synonym: "sodium(I) cation" RELATED IUPAC:NAME [iupac]
xref: cas:17341-25-2 {source="cas"}
xref: gmelin:15196 {source="gmelin"}
xref: kegg.compound:C01330 {source="kegg.compound"}
xref: pdb-ccd:NA {source="pdb-ccd"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:25414 ! monoatomic monocation
is_a: CHEBI:33504 ! alkali metal cation
is_a: CHEBI:37246 ! elemental sodium
is_a: CHEBI:60242 ! monovalent inorganic cation
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
[Term]
id: CHEBI:29103
name: potassium(1+)
alt_id: CHEBI:26219
alt_id: CHEBI:49685
alt_id: CHEBI:8345
def: "A monoatomic monocation obtained from potassium." []
subset: 3:STAR
synonym: "K(+)" RELATED [iupac, uniprot_ft]
synonym: "K+" RELATED [kegg.compound]
synonym: "potassium cation" EXACT IUPAC:NAME [IUPAC]
synonym: "potassium cation" RELATED IUPAC:NAME [iupac]
synonym: "POTASSIUM ION" RELATED [pdb-ccd]
synonym: "potassium(1+)" EXACT IUPAC:NAME [IUPAC]
synonym: "potassium(1+)" RELATED IUPAC:NAME [iupac]
synonym: "potassium(1+) ion" EXACT IUPAC:NAME [IUPAC]
synonym: "potassium(1+) ion" RELATED IUPAC:NAME [iupac]
synonym: "potassium(I) cation" EXACT IUPAC:NAME [IUPAC]
synonym: "potassium(I) cation" RELATED IUPAC:NAME [iupac]
xref: cas:24203-36-9 {source="cas"}
xref: gmelin:15203 {source="gmelin"}
xref: kegg.compound:C00238 {source="kegg.compound"}
xref: kegg.drug:D08403 {source="kegg.drug"}
xref: pdb-ccd:K {source="pdb-ccd"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:25414 ! monoatomic monocation
is_a: CHEBI:33504 ! alkali metal cation
is_a: CHEBI:37247 ! elemental potassium
is_a: CHEBI:60242 ! monovalent inorganic cation
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
[Term]
id: CHEBI:29108
name: calcium(2+)
alt_id: CHEBI:22988
alt_id: CHEBI:3308
alt_id: CHEBI:48760
subset: 3:STAR
synonym: "Ca(2+)" RELATED [iupac, uniprot_ft]
synonym: "Ca2+" RELATED [kegg.compound]
synonym: "CALCIUM ION" RELATED [pdb-ccd]
synonym: "calcium(2+)" EXACT IUPAC:NAME [IUPAC]
synonym: "calcium(2+)" RELATED IUPAC:NAME [iupac]
synonym: "calcium(2+) ion" EXACT IUPAC:NAME [IUPAC]
synonym: "calcium(2+) ion" RELATED IUPAC:NAME [iupac]
synonym: "calcium(II) cation" EXACT IUPAC:NAME [IUPAC]
synonym: "calcium(II) cation" RELATED IUPAC:NAME [iupac]
synonym: "calcium, doubly charged positive ion" RELATED [nist]
xref: cas:14127-61-8 {source="cas"}
xref: gmelin:6850 {source="gmelin"}
xref: kegg.compound:C00076 {source="kegg.compound"}
xref: pdb-ccd:CA {source="pdb-ccd"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:30412 ! monoatomic dication
is_a: CHEBI:39123 ! calcium cation
is_a: CHEBI:60240 ! divalent metal cation
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
[Term]
id: CHEBI:29337
name: azanide
subset: 3:STAR
synonym: "amide" EXACT IUPAC:NAME [IUPAC]
synonym: "amide" RELATED IUPAC:NAME [iupac]
synonym: "azanide" EXACT IUPAC:NAME [IUPAC]
synonym: "azanide" RELATED IUPAC:NAME [iupac]
synonym: "dihydridonitrate(1-)" EXACT IUPAC:NAME [IUPAC]
synonym: "dihydridonitrate(1-)" RELATED IUPAC:NAME [iupac]
synonym: "NH2(-)" RELATED [iupac]
is_a: CHEBI:35106 ! nitrogen hydride
is_a: CHEBI:79389 ! monovalent inorganic anion
relationship: RO:0018033 CHEBI:16134 ! is deprotonated form of ammonia
relationship: RO:0018034 CHEBI:29340 ! is protonated form of hydridonitrate(2-)
[Term]
id: CHEBI:29340
name: hydridonitrate(2-)
def: "A divalent inorganic anion resulting from the removal of two protons from ammonia." []
subset: 3:STAR
synonym: "azanediide" EXACT IUPAC:NAME [IUPAC]
synonym: "azanediide" RELATED IUPAC:NAME [iupac]
synonym: "hydridonitrate(2-)" EXACT IUPAC:NAME [IUPAC]
synonym: "hydridonitrate(2-)" RELATED IUPAC:NAME [iupac]
synonym: "imide" RELATED [iupac]
synonym: "NH(2-)" RELATED [iupac]
is_a: CHEBI:35106 ! nitrogen hydride
is_a: CHEBI:79388 ! divalent inorganic anion
relationship: RO:0018033 CHEBI:29337 ! is deprotonated form of azanide
[Term]
id: CHEBI:29412
name: oxonium
subset: 3:STAR
synonym: "[OH3](+)" RELATED [molbase]
synonym: "aquahydrogen(1+)" EXACT IUPAC:NAME [IUPAC]
synonym: "aquahydrogen(1+)" RELATED IUPAC:NAME [iupac]
synonym: "H3O(+)" RELATED [iupac]
synonym: "Hydronium cation" RELATED [nist]
synonym: "Hydronium ion" RELATED [chemidplus]
synonym: "oxidanium" EXACT IUPAC:NAME [IUPAC]
synonym: "oxidanium" RELATED IUPAC:NAME [iupac]
synonym: "oxonium" EXACT IUPAC:NAME [IUPAC]
synonym: "oxonium" RELATED IUPAC:NAME [iupac]
synonym: "trihydridooxygen(1+)" EXACT IUPAC:NAME [IUPAC]
synonym: "trihydridooxygen(1+)" RELATED IUPAC:NAME [iupac]
xref: cas:13968-08-6 {source="cas"}
xref: gmelin:141 {source="gmelin"}
xref: molbase:1646 {source="molbase"}
is_a: CHEBI:33693 ! oxygen hydride
is_a: CHEBI:50313 ! onium cation
relationship: RO:0018034 CHEBI:15377 ! is protonated form of water
[Term]
id: CHEBI:29793
name: hydridodioxygen(1+)
subset: 3:STAR
synonym: "[HO2](+)" RELATED [chebi]
synonym: "dioxidenium" EXACT IUPAC:NAME [IUPAC]
synonym: "dioxidenium" RELATED IUPAC:NAME [iupac]
synonym: "HO2(+)" RELATED [iupac]
synonym: "HOO(+)" RELATED [chebi]
synonym: "hydridodioxygen(1+)" EXACT IUPAC:NAME [IUPAC]
synonym: "hydridodioxygen(1+)" RELATED IUPAC:NAME [iupac]
xref: gmelin:508 {source="gmelin"}
is_a: CHEBI:33693 ! oxygen hydride
relationship: RO:0018034 CHEBI:15379 ! is protonated form of dioxygen
[Term]
id: CHEBI:29934
name: (1s,4s)-prephenate(2-)
alt_id: CHEBI:14884
alt_id: CHEBI:26256
def: "A prephenate(2−) obtained by deprotonation of both carboxy groups of (1s,4s)-prephenic acid; major species at pH 7.3." []
subset: 3:STAR
synonym: "(1s,4s)-1-(2-carboxylato-2-oxoethyl)-4-hydroxycyclohexa-2,5-diene-1-carboxylate" EXACT IUPAC:NAME [IUPAC]
synonym: "(1s,4s)-1-(2-carboxylato-2-oxoethyl)-4-hydroxycyclohexa-2,5-diene-1-carboxylate" RELATED IUPAC:NAME [iupac]
synonym: "cis-1-(2-carboxylato-2-oxoethyl)-4-hydroxycyclohexa-2,5-diene-1-carboxylate" EXACT IUPAC:NAME [IUPAC]
synonym: "cis-1-(2-carboxylato-2-oxoethyl)-4-hydroxycyclohexa-2,5-diene-1-carboxylate" RELATED IUPAC:NAME [iupac]
synonym: "cis-prephenate" RELATED [chebi]
synonym: "prephenate" RELATED [uniprot_ft]
xref: kegg.compound:C00254 {source="kegg.compound"}
xref: metacyc.compound:PREPHENATE {source="metacyc.compound"}
xref: reaxys:3682733 {source="reaxys"}
is_a: CHEBI:57852 ! prephenate(2-)
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0018033 CHEBI:16666 ! is deprotonated form of prephenic acid
relationship: RO:0018033 CHEBI:84387 ! is deprotonated form of (1s,4s)-prephenic acid
[Term]
id: CHEBI:29976
name: D-tyrosine residue
subset: 3:STAR
synonym: "D-Tyr" RELATED [jcbn]
synonym: "D-tyrosine acid residue" RELATED [jcbn]
synonym: "D-tyrosine residue" RELATED [jcbn]
synonym: "D-tyrosyl" RELATED [chebi]
synonym: "DTyr" RELATED [jcbn]
is_a: CHEBI:32789 ! tyrosine residue
relationship: RO:0018037 CHEBI:28479 ! is substitutent group from D-tyrosine
relationship: RO:0018039 CHEBI:46858 ! is enantiomer of L-tyrosine residue
[Term]
id: CHEBI:29985
name: L-glutamate(1-)
alt_id: CHEBI:13107
alt_id: CHEBI:21301
def: "An α-amino-acid anion that is the conjugate base of L-glutamic acid, having anionic carboxy groups and a cationic amino group" []
subset: 3:STAR
synonym: "(2S)-2-ammoniopentanedioate" RELATED [iupac]
synonym: "hydrogen L-glutamate" EXACT IUPAC:NAME [IUPAC]
synonym: "hydrogen L-glutamate" RELATED IUPAC:NAME [iupac]
synonym: "L-glutamate" EXACT [ChEBI]
synonym: "L-glutamate" RELATED [chebi, uniprot_ft]
synonym: "L-glutamate(1-)" RELATED [jcbn]
synonym: "L-glutamic acid monoanion" RELATED [jcbn]
synonym: "L-glutamic acid, ion(1-)" RELATED [chemidplus]
xref: cas:11070-68-1 {source="cas"}
xref: gmelin:936654 {source="gmelin"}
xref: metacyc.compound:GLT {source="metacyc.compound"}
is_a: CHEBI:14321 ! glutamate(1-)
relationship: RO:0000087 CHEBI:24319 ! has role EC 6.3.1.2 (glutamate--ammonia ligase) inhibitor
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018033 CHEBI:16015 ! is deprotonated form of L-glutamic acid
relationship: RO:0018034 CHEBI:29988 ! is protonated form of L-glutamate(2-)
relationship: RO:0018039 CHEBI:29986 ! is enantiomer of D-glutamate(1-)
[Term]
id: CHEBI:29986
name: D-glutamate(1-)
alt_id: CHEBI:12979
alt_id: CHEBI:21022
def: "An α-amino-acid anion that is the conjugate base of D-glutamic acid, having anionic carboxy groups and a cationic amino group" []
subset: 3:STAR
synonym: "(2R)-2-ammoniopentanedioate" RELATED [iupac]
synonym: "D-glutamate" RELATED [uniprot_ft]
synonym: "D-glutamate(1-)" RELATED [jcbn]
synonym: "D-glutamic acid monoanion" RELATED [jcbn]
synonym: "hydrogen D-glutamate" EXACT IUPAC:NAME [IUPAC]
synonym: "hydrogen D-glutamate" RELATED IUPAC:NAME [iupac]
xref: beilstein:8319427 {source="beilstein"}
xref: metacyc.compound:D-GLT {source="metacyc.compound"}
is_a: CHEBI:14321 ! glutamate(1-)
relationship: RO:0018033 CHEBI:15966 ! is deprotonated form of D-glutamic acid
relationship: RO:0018034 CHEBI:29989 ! is protonated form of D-glutamate(2-)
relationship: RO:0018039 CHEBI:29985 ! is enantiomer of L-glutamate(1-)
[Term]
id: CHEBI:29987
name: glutamate(2-)
def: "A dicarboxylic acid dianion that is the conjugate base of glutamate(1−)." []
subset: 3:STAR
synonym: "2-aminopentanedioate" EXACT IUPAC:NAME [IUPAC]
synonym: "2-aminopentanedioate" RELATED IUPAC:NAME [iupac]
synonym: "glutamate" EXACT IUPAC:NAME [IUPAC]
synonym: "glutamate" RELATED IUPAC:NAME [iupac]
synonym: "glutamate(2-)" RELATED [jcbn]
synonym: "glutamic acid dianion" RELATED [jcbn]
xref: gmelin:327903 {source="gmelin"}
xref: reaxys:4134100 {source="reaxys"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:28965 ! dicarboxylic acid dianion
relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
relationship: RO:0018033 CHEBI:14321 ! is deprotonated form of glutamate(1-)
[Term]
id: CHEBI:29988
name: L-glutamate(2-)
def: "An L-α-amino acid anion that is the dianion obtained by the deprotonation of the both the carboxy groups of L-glutamic acid." []
subset: 3:STAR
synonym: "(2S)-2-aminopentanedioate" EXACT IUPAC:NAME [IUPAC]
synonym: "(2S)-2-aminopentanedioate" RELATED IUPAC:NAME [iupac]
synonym: "L-glutamate" EXACT IUPAC:NAME [IUPAC]
synonym: "L-glutamate" RELATED IUPAC:NAME [iupac]
synonym: "L-glutamate(2-)" RELATED [jcbn]
synonym: "L-glutamic acid dianion" RELATED [jcbn]
xref: gmelin:327905 {source="gmelin"}
is_a: CHEBI:29987 ! glutamate(2-)
is_a: CHEBI:59814 ! L-alpha-amino acid anion
relationship: RO:0018033 CHEBI:29985 ! is deprotonated form of L-glutamate(1-)
relationship: RO:0018039 CHEBI:29989 ! is enantiomer of D-glutamate(2-)
[Term]
id: CHEBI:29989
name: D-glutamate(2-)
subset: 3:STAR
synonym: "(2R)-2-aminopentanedioate" EXACT IUPAC:NAME [IUPAC]
synonym: "(2R)-2-aminopentanedioate" RELATED IUPAC:NAME [iupac]
synonym: "D-glutamate" EXACT IUPAC:NAME [IUPAC]
synonym: "D-glutamate" RELATED IUPAC:NAME [iupac]
synonym: "D-glutamate(2-)" RELATED [jcbn]
synonym: "D-glutamic acid dianion" RELATED [jcbn]
xref: beilstein:8143000 {source="beilstein"}
xref: gmelin:327904 {source="gmelin"}
is_a: CHEBI:29987 ! glutamate(2-)
relationship: RO:0018033 CHEBI:29986 ! is deprotonated form of D-glutamate(1-)
relationship: RO:0018039 CHEBI:29988 ! is enantiomer of L-glutamate(2-)
[Term]
id: CHEBI:30089
name: acetate
alt_id: CHEBI:13704
alt_id: CHEBI:22165
alt_id: CHEBI:40480
def: "A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of acetic acid." []
subset: 3:STAR
synonym: "acetate" EXACT IUPAC:NAME [IUPAC]
synonym: "acetate" RELATED IUPAC:NAME [iupac, uniprot_ft]
synonym: "ACETATE ION" RELATED [pdb-ccd]
synonym: "acetic acid, ion(1-)" RELATED [chemidplus]
synonym: "Azetat" RELATED [chebi]
synonym: "CH3-COO(-)" RELATED [iupac]
synonym: "Ethanoat" RELATED [chebi]
synonym: "ethanoate" RELATED [chebi]
synonym: "MeCO2 anion" RELATED [nist]
xref: cas:71-50-1 {source="cas"}
xref: drugbank:DB03166 {source="drugbank"}
xref: gmelin:1379 {source="gmelin"}
xref: kegg.compound:C00033 {source="kegg.compound"}
xref: metacyc.compound:ACET {source="metacyc.compound"}
xref: pdb-ccd:ACT {source="pdb-ccd"}
xref: pubmed:17190852 {source="pubmed"}
xref: pubmed:22211106 {source="pubmed"}
xref: pubmed:22371380 {source="pubmed"}
xref: reaxys:1901470 {source="reaxys"}
xref: umbbd.compound:c0050 {source="umbbd.compound"}
xref: wikipedia.en:Acetate {source="wikipedia.en"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:35757 ! monocarboxylic acid anion
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018033 CHEBI:15366 ! is deprotonated form of acetic acid
[Term]
id: CHEBI:30212
name: photon
alt_id: CHEBI:10581
alt_id: CHEBI:14383
def: "Particle of zero charge, zero rest mass, spin quantum number 1, energy hν and momentum hν/c (h is the Planck constant, ν the frequency of radiation and c the speed of light), carrier of electromagnetic force." []
subset: 3:STAR
synonym: "foton" RELATED [chebi]
synonym: "gamma" RELATED [iupac]
synonym: "h-nu" RELATED [uniprot_ft]
synonym: "hnu" RELATED [iupac]
synonym: "Lichtquant" RELATED [chebi]
synonym: "Light" RELATED [kegg.compound]
synonym: "light quantum" RELATED [chebi]
synonym: "photon" EXACT IUPAC:NAME [IUPAC]
synonym: "photon" RELATED IUPAC:NAME [iupac]
xref: kegg.compound:C00205 {source="kegg.compound"}
is_a: CHEBI:36341 ! boson
[Term]
id: CHEBI:30412
name: monoatomic dication
alt_id: CHEBI:23856
alt_id: CHEBI:4665
subset: 3:STAR
synonym: "Divalent cation" RELATED [kegg.compound]
synonym: "divalent inorganic cations" RELATED [chebi]
synonym: "monoatomic dications" RELATED [chebi]
xref: kegg.compound:C00572 {source="kegg.compound"}
is_a: CHEBI:23906 ! monoatomic cation
[Term]
id: CHEBI:30566
name: gamma-aminobutyrate
alt_id: CHEBI:11961
alt_id: CHEBI:20317
def: "An γ-amino acid anion resulting from the deprotonation of the carboxy group of γ-aminobutyric acid." []
subset: 3:STAR
synonym: "4-Amino-butyrat" RELATED [chebi]
synonym: "4-aminobutanoate" EXACT IUPAC:NAME [IUPAC]
synonym: "4-aminobutanoate" RELATED IUPAC:NAME [iupac]
synonym: "4-aminobutanoic acid ion (1-)" RELATED [chebi]
synonym: "4-Aminobutylate" RELATED [kegg.compound]
synonym: "4-aminobutyrate" RELATED [chebi]
synonym: "gamma-aminobutanoate" RELATED [chebi]
synonym: "gamma-aminobutyrate anion" RELATED [chebi]
xref: gmelin:559138 {source="gmelin"}
xref: kegg.compound:C00334 {source="kegg.compound"}
xref: pubmed:12509893 {source="pubmed"}
xref: reaxys:3536873 {source="reaxys"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:71666 ! gamma-amino acid anion
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018033 CHEBI:16865 ! is deprotonated form of gamma-aminobutyric acid
relationship: RO:0018038 CHEBI:17968 ! has functional parent butyrate
[Term]
id: CHEBI:30616
name: ATP(4-)
def: "A nucleoside triphosphate(4−) obtained by global deprotonation of the triphosphate OH groups of ATP; major species present at pH 7.3." []
subset: 3:STAR
synonym: "adenosine 5'-triphosphate(4-)" EXACT IUPAC:NAME [IUPAC]
synonym: "adenosine 5'-triphosphate(4-)" RELATED IUPAC:NAME [iupac]
synonym: "ATP" RELATED [uniprot_ft]
synonym: "atp" RELATED [iupac]
xref: beilstein:3581767 {source="beilstein"}
xref: gmelin:342798 {source="gmelin"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:61557 ! nucleoside 5'-triphoshate(4-)
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
relationship: RO:0018033 CHEBI:57299 ! is deprotonated form of ATP(3-)
[Term]
id: CHEBI:30751
name: formic acid
alt_id: CHEBI:24082
alt_id: CHEBI:42460
alt_id: CHEBI:5145
def: "The simplest carboxylic acid, containing a single carbon. Occurs naturally in various sources including the venom of bee and ant stings, and is a useful organic synthetic reagent. Principally used as a preservative and antibacterial agent in livestock feed. Induces severe metabolic acidosis and ocular injury in human subjects." []
subset: 3:STAR
synonym: "Acide formique" RELATED [chemidplus]
synonym: "Ameisensaeure" RELATED [chemidplus]
synonym: "aminic acid" RELATED [chemidplus]
synonym: "bilorin" RELATED [chemidplus]
synonym: "FORMIC ACID" EXACT [PDBeChem]
synonym: "FORMIC ACID" RELATED [pdb-ccd]
synonym: "Formic acid" EXACT [KEGG_COMPOUND]
synonym: "Formic acid" RELATED [kegg.compound]
synonym: "formic acid" EXACT IUPAC:NAME [IUPAC]
synonym: "formic acid" RELATED IUPAC:NAME [iupac]
synonym: "formylic acid" RELATED [chemidplus]
synonym: "H-COOH" RELATED [iupac]
synonym: "HCO2H" RELATED [chebi]
synonym: "HCOOH" RELATED [nist]
synonym: "hydrogen carboxylic acid" RELATED [chemidplus]
synonym: "Methanoic acid" RELATED [kegg.compound]
synonym: "methoic acid" RELATED [chebi]
xref: bpdb:1749 {source="bpdb"}
xref: cas:64-18-6 {source="cas"}
xref: drugbank:DB01942 {source="drugbank"}
xref: gmelin:1008 {source="gmelin"}
xref: hmdb:HMDB0000142 {source="hmdb"}
xref: kegg.compound:C00058 {source="kegg.compound"}
xref: knapsack:C00001182 {source="knapsack"}
xref: lipidmaps:LMFA01010040 {source="lipidmaps"}
xref: metacyc.compound:FORMATE {source="metacyc.compound"}
xref: patent:CN101481304 {source="patent"}
xref: pdb-ccd:FMT {source="pdb-ccd"}
xref: pubmed:12591956 {source="pubmed"}
xref: pubmed:14637377 {source="pubmed"}
xref: pubmed:15811469 {source="pubmed"}
xref: pubmed:16120414 {source="pubmed"}
xref: pubmed:16185830 {source="pubmed"}
xref: pubmed:16222862 {source="pubmed"}
xref: pubmed:16230297 {source="pubmed"}
xref: pubmed:16445901 {source="pubmed"}
xref: pubmed:16465784 {source="pubmed"}
xref: pubmed:18034701 {source="pubmed"}
xref: pubmed:18397576 {source="pubmed"}
xref: pubmed:22080171 {source="pubmed"}
xref: pubmed:22280475 {source="pubmed"}
xref: pubmed:22304812 {source="pubmed"}
xref: pubmed:22385261 {source="pubmed"}
xref: pubmed:22447125 {source="pubmed"}
xref: pubmed:22483350 {source="pubmed"}
xref: pubmed:22499553 {source="pubmed"}
xref: pubmed:22540994 {source="pubmed"}
xref: pubmed:22606986 {source="pubmed"}
xref: pubmed:22622393 {source="pubmed"}
xref: pubmed:3946945 {source="pubmed"}
xref: pubmed:7361809 {source="pubmed"}
xref: reaxys:1209246 {source="reaxys"}
xref: wikipedia.en:Formic_acid {source="wikipedia.en"}
is_a: CHEBI:25384 ! monocarboxylic acid
relationship: RO:0000087 CHEBI:25212 ! has role metabolite
relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent
relationship: RO:0000087 CHEBI:46787 ! has role solvent
relationship: RO:0000087 CHEBI:48356 ! has role protic solvent
relationship: RO:0000087 CHEBI:74783 ! has role astringent
relationship: RO:0018034 CHEBI:15740 ! is protonated form of formate
[Term]
id: CHEBI:30768
name: propionic acid
alt_id: CHEBI:26304
alt_id: CHEBI:45227
alt_id: CHEBI:8476
def: "A short-chain saturated fatty acid comprising ethane attached to the carbon of a carboxy group." []
subset: 3:STAR
synonym: "acide propanoique" RELATED [chebi]
synonym: "acide propionique" RELATED [nist]
synonym: "carboxyethane" RELATED [chemidplus]
synonym: "CH3-CH2-COOH" RELATED [iupac]
synonym: "ethanecarboxylic acid" RELATED [chemidplus]
synonym: "ethylformic acid" RELATED [chemidplus]
synonym: "metacetonic acid" RELATED [chemidplus]
synonym: "methylacetic acid" RELATED [chemidplus]
synonym: "PA" RELATED [chebi]
synonym: "PROPANOIC ACID" EXACT [PDBeChem]
synonym: "PROPANOIC ACID" RELATED [pdb-ccd]
synonym: "Propanoic acid" EXACT [KEGG_COMPOUND]
synonym: "Propanoic acid" RELATED [kegg.compound]
synonym: "propanoic acid" EXACT IUPAC:NAME [IUPAC]
synonym: "propanoic acid" RELATED IUPAC:NAME [iupac]
synonym: "propioic acid" RELATED [lipidmaps]
synonym: "Propionic acid" RELATED [kegg.compound]
synonym: "propionic acid" RELATED [iupac]
synonym: "Propionsaeure" RELATED [chebi]
synonym: "propoic acid" RELATED [chebi]
synonym: "pseudoacetic acid" RELATED [chemidplus]
xref: beilstein:506071 {source="beilstein"}
xref: cas:79-09-4 {source="cas"}
xref: drugbank:DB03766 {source="drugbank"}
xref: gmelin:1821 {source="gmelin"}
xref: kegg.compound:C00163 {source="kegg.compound"}
xref: kegg.drug:D02310 {source="kegg.drug"}
xref: lipidmaps:LMFA01010003 {source="lipidmaps"}
xref: pdb-ccd:PPI {source="pdb-ccd"}
xref: ppdb:1341 {source="ppdb"}
xref: pubmed:15868474 {source="pubmed"}
xref: pubmed:1628870 {source="pubmed"}
xref: pubmed:16763906 {source="pubmed"}
is_a: CHEBI:26607 ! saturated fatty acid
is_a: CHEBI:26666 ! short-chain fatty acid
relationship: RO:0000087 CHEBI:86327 ! has role antifungal drug
relationship: RO:0018034 CHEBI:17272 ! is protonated form of propionate
[Term]
id: CHEBI:30772
name: butyric acid
alt_id: CHEBI:113450
alt_id: CHEBI:22948
alt_id: CHEBI:3234
alt_id: CHEBI:41208
def: "A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group." []
subset: 3:STAR
synonym: "1-butanoic acid" RELATED [hmdb]
synonym: "1-butyric acid" RELATED [hmdb]
synonym: "1-propanecarboxylic acid" RELATED [metacyc.compound]
synonym: "4:0" RELATED [chebi]
synonym: "acide butanoique" RELATED [iupac]
synonym: "acide butyrique" RELATED [chebi]
synonym: "butanic acid" RELATED [chebi]
synonym: "Butanoate" RELATED [kegg.compound]
synonym: "BUTANOIC ACID" EXACT [PDBeChem]
synonym: "BUTANOIC ACID" RELATED [pdb-ccd]
synonym: "Butanoic acid" EXACT [KEGG_COMPOUND]
synonym: "Butanoic acid" RELATED [kegg.compound]
synonym: "butanoic acid" EXACT IUPAC:NAME [IUPAC]
synonym: "butanoic acid" RELATED IUPAC:NAME [iupac]
synonym: "butoic acid" RELATED [chebi]
synonym: "Buttersaeure" RELATED [chebi]
synonym: "Butyric acid" RELATED [kegg.compound]
synonym: "butyric acid" RELATED [iupac]
synonym: "C4:0" RELATED [chebi]
synonym: "CH3-[CH2]2-COOH" RELATED [iupac]
synonym: "ethylacetic acid" RELATED [nist]
synonym: "n-butanoic acid" RELATED [nist]
synonym: "n-butyric acid" RELATED [nist]
synonym: "propanecarboxylic acid" RELATED [hmdb]
synonym: "propylformic acid" RELATED [metacyc.compound]
xref: cas:107-92-6 {source="cas"}
xref: drugbank:DB03568 {source="drugbank"}
xref: gmelin:26242 {source="gmelin"}
xref: hmdb:HMDB0000039 {source="hmdb"}
xref: kegg.compound:C00246 {source="kegg.compound"}
xref: knapsack:C00001180 {source="knapsack"}
xref: lipidmaps:LMFA01010004 {source="lipidmaps"}
xref: metacyc.compound:BUTYRIC_ACID {source="metacyc.compound"}
xref: pdb-ccd:BUA {source="pdb-ccd"}
xref: pubmed:10736622 {source="pubmed"}
xref: pubmed:10956204 {source="pubmed"}
xref: pubmed:11201044 {source="pubmed"}
xref: pubmed:11208715 {source="pubmed"}
xref: pubmed:11238216 {source="pubmed"}
xref: pubmed:11305323 {source="pubmed"}
xref: pubmed:12068484 {source="pubmed"}
xref: pubmed:13678314 {source="pubmed"}
xref: pubmed:14962641 {source="pubmed"}
xref: pubmed:1542095 {source="pubmed"}
xref: pubmed:15809727 {source="pubmed"}
xref: pubmed:15810631 {source="pubmed"}
xref: pubmed:15938880 {source="pubmed"}
xref: pubmed:19318247 {source="pubmed"}
xref: pubmed:19366864 {source="pubmed"}
xref: pubmed:19703412 {source="pubmed"}
xref: pubmed:21699495 {source="pubmed"}
xref: pubmed:22038864 {source="pubmed"}
xref: pubmed:22194341 {source="pubmed"}
xref: pubmed:22322557 {source="pubmed"}
xref: pubmed:22339023 {source="pubmed"}
xref: pubmed:22466881 {source="pubmed"}
xref: reaxys:906770 {source="reaxys"}
xref: wikipedia.en:Butyric_acid {source="wikipedia.en"}
is_a: CHEBI:140601 ! fatty acid 4:0
is_a: CHEBI:39418 ! straight-chain saturated fatty acid
relationship: RO:0000087 CHEBI:131604 ! has role Mycoplasma genitalium metabolite
relationship: RO:0000087 CHEBI:84087 ! has role human urinary metabolite
relationship: RO:0018034 CHEBI:17968 ! is protonated form of butyrate
[Term]
id: CHEBI:30879
name: alcohol
alt_id: CHEBI:13804
alt_id: CHEBI:22288
alt_id: CHEBI:2553
def: "A compound in which a hydroxy group, ‒OH, is attached to a saturated carbon atom." []
subset: 3:STAR
synonym: "Alcohol" RELATED [kegg.compound]
synonym: "alcohols" EXACT IUPAC:NAME [IUPAC]
synonym: "alcohols" RELATED IUPAC:NAME [iupac]
synonym: "an alcohol" RELATED [uniprot_ft]
xref: kegg.compound:C00069 {source="kegg.compound"}
is_a: CHEBI:33822 ! organic hydroxy compound
[Term]
id: CHEBI:3098
name: bile acid
def: "Any member of a group of hydroxy-5β-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5β-configuration." []
subset: 3:STAR
synonym: "5beta-bile acid" RELATED [chebi]
synonym: "5beta-bile acids" RELATED [chebi]
synonym: "Bile acid" RELATED [kegg.compound]
synonym: "bile acids" RELATED [chebi]
synonym: "Bile salt" RELATED [kegg.compound]
synonym: "Gallensaeure" RELATED [chebi]
synonym: "Gallensaeuren" RELATED [chebi]
xref: kegg.compound:C01558 {source="kegg.compound"}
is_a: CHEBI:138366 ! bile acids
is_a: CHEBI:24663 ! hydroxy-5beta-cholanic acid
[Term]
id: CHEBI:32486
name: L-phenylalaninate
def: "An optically active form of phenylalaninate having L-configuration." []
subset: 3:STAR
synonym: "(2S)-2-amino-3-phenylpropanoate" RELATED [iupac]
synonym: "L-phenylalaninate" EXACT IUPAC:NAME [IUPAC]
synonym: "L-phenylalaninate" RELATED IUPAC:NAME [iupac]
synonym: "L-phenylalanine anion" RELATED [jcbn]
xref: gmelin:329084 {source="gmelin"}
xref: pubmed:21956539 {source="pubmed"}
xref: reaxys:4136718 {source="reaxys"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:32504 ! phenylalaninate
is_a: CHEBI:59814 ! L-alpha-amino acid anion
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0018033 CHEBI:17295 ! is deprotonated form of L-phenylalanine
relationship: RO:0018039 CHEBI:32494 ! is enantiomer of D-phenylalaninate
[Term]
id: CHEBI:32487
name: L-phenylalaninium
def: "An optically active form of phenylalaninium having L-configuration." []
subset: 3:STAR
synonym: "(1S)-1-carboxy-2-phenylethanaminium" RELATED [iupac]
synonym: "L-phenylalanine cation" RELATED [jcbn]
synonym: "L-phenylalaninium" EXACT IUPAC:NAME [IUPAC]
synonym: "L-phenylalaninium" RELATED IUPAC:NAME [iupac]
xref: pubmed:21956539 {source="pubmed"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:32505 ! phenylalaninium
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0018034 CHEBI:17295 ! is protonated form of L-phenylalanine
relationship: RO:0018039 CHEBI:32495 ! is enantiomer of D-phenylalaninium
[Term]
id: CHEBI:32494
name: D-phenylalaninate
def: "The D-enantiomer of phenylalaninate." []
subset: 3:STAR
synonym: "(2R)-2-amino-3-phenylpropanoate" RELATED [iupac]
synonym: "D-phenylalaninate" EXACT IUPAC:NAME [IUPAC]
synonym: "D-phenylalaninate" RELATED IUPAC:NAME [iupac]
synonym: "D-phenylalanine anion" RELATED [jcbn]
xref: beilstein:5740552 {source="beilstein"}
xref: gmelin:746993 {source="gmelin"}
is_a: CHEBI:32504 ! phenylalaninate
relationship: RO:0018033 CHEBI:16998 ! is deprotonated form of D-phenylalanine
relationship: RO:0018039 CHEBI:32486 ! is enantiomer of L-phenylalaninate
[Term]
id: CHEBI:32495
name: D-phenylalaninium
def: "An optically active form of phenylalaninium having D-configuration." []
subset: 3:STAR
synonym: "(1R)-1-carboxy-2-phenylethanaminium" RELATED [iupac]
synonym: "D-phenylalanine cation" RELATED [jcbn]
synonym: "D-phenylalaninium" EXACT IUPAC:NAME [IUPAC]
synonym: "D-phenylalaninium" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:32505 ! phenylalaninium
relationship: RO:0018034 CHEBI:16998 ! is protonated form of D-phenylalanine
relationship: RO:0018039 CHEBI:32487 ! is enantiomer of L-phenylalaninium
[Term]
id: CHEBI:32504
name: phenylalaninate
def: "An aromatic amino-acid anion that is the conjugate base of phenylalanine, arising from deprotonation of the carboxy group." []
subset: 3:STAR
synonym: "2-amino-3-phenylpropanoate" RELATED [iupac]
synonym: "phenylalaninate" EXACT IUPAC:NAME [IUPAC]
synonym: "phenylalaninate" RELATED IUPAC:NAME [iupac]
synonym: "phenylalanine anion" RELATED [jcbn]
xref: gmelin:329083 {source="gmelin"}
is_a: CHEBI:33558 ! alpha-amino-acid anion
is_a: CHEBI:63473 ! aromatic amino-acid anion
relationship: RO:0018033 CHEBI:28044 ! is deprotonated form of phenylalanine
[Term]
id: CHEBI:32505
name: phenylalaninium
def: "An α-amino-acid cation that is the conjugate acid of phenylalanine, arising from protonation of the amino group." []
subset: 3:STAR
synonym: "1-carboxy-2-phenylethanaminium" RELATED [iupac]
synonym: "phenylalanine cation" RELATED [jcbn]
synonym: "phenylalaninium" EXACT IUPAC:NAME [IUPAC]
synonym: "phenylalaninium" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:33719 ! alpha-amino-acid cation
relationship: RO:0018034 CHEBI:28044 ! is protonated form of phenylalanine
[Term]
id: CHEBI:32760
name: L-tyrosinate(1-)
def: "An optically active form of tyrosinate having L-configuration." []
subset: 3:STAR
synonym: "(2S)-2-amino-3-(4-hydroxyphenyl)propanoate" RELATED [iupac]
synonym: "hydrogen L-tyrosinate" EXACT IUPAC:NAME [IUPAC]
synonym: "hydrogen L-tyrosinate" RELATED IUPAC:NAME [iupac]
synonym: "L-tyrosinate(1-)" RELATED [jcbn]
synonym: "L-tyrosine anion" RELATED [nist]
synonym: "L-tyrosine monoanion" RELATED [jcbn]
xref: gmelin:329373 {source="gmelin"}
xref: reaxys:4784244 {source="reaxys"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:32784 ! tyrosinate(1-)
is_a: CHEBI:59814 ! L-alpha-amino acid anion
relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
relationship: RO:0018033 CHEBI:17895 ! is deprotonated form of L-tyrosine
relationship: RO:0018033 CHEBI:58315 ! is deprotonated form of L-tyrosine zwitterion
relationship: RO:0018034 CHEBI:32761 ! is protonated form of L-tyrosinate(2-)
relationship: RO:0018039 CHEBI:32773 ! is enantiomer of D-tyrosinate(1-)
[Term]
id: CHEBI:32761
name: L-tyrosinate(2-)
def: "The L-enantiomer of tyrosinate(2−)." []
subset: 3:STAR
synonym: "(2S)-2-amino-3-(4-oxidophenyl)propanoate" RELATED [iupac]
synonym: "L-tyrosinate" EXACT IUPAC:NAME [IUPAC]
synonym: "L-tyrosinate" RELATED IUPAC:NAME [iupac]
synonym: "L-tyrosinate(2-)" RELATED [jcbn]
synonym: "L-tyrosine dianion" RELATED [jcbn]
xref: gmelin:364975 {source="gmelin"}
xref: reaxys:5339596 {source="reaxys"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:32785 ! tyrosinate(2-)
relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
relationship: RO:0018033 CHEBI:32760 ! is deprotonated form of L-tyrosinate(1-)
relationship: RO:0018039 CHEBI:32774 ! is enantiomer of D-tyrosinate(2-)
[Term]
id: CHEBI:32762
name: L-tyrosinium
def: "An optically active form of tyrosinium having L-configuration." []
subset: 3:STAR
synonym: "(1S)-1-carboxy-2-(4-hydroxyphenyl)ethanaminium" RELATED [iupac]
synonym: "L-tyrosine cation" RELATED [jcbn]
synonym: "L-tyrosinium" EXACT IUPAC:NAME [IUPAC]
synonym: "L-tyrosinium" RELATED IUPAC:NAME [iupac]
xref: gmelin:1150138 {source="gmelin"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:32786 ! tyrosinium
relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
relationship: RO:0018034 CHEBI:17895 ! is protonated form of L-tyrosine
relationship: RO:0018034 CHEBI:58315 ! is protonated form of L-tyrosine zwitterion
relationship: RO:0018039 CHEBI:32775 ! is enantiomer of D-tyrosinium
[Term]
id: CHEBI:32773
name: D-tyrosinate(1-)
def: "An optically active form of tyrosinate(1−) having D-configuration." []
subset: 3:STAR
synonym: "(2R)-2-amino-3-(4-hydroxyphenyl)propanoate" RELATED [iupac]
synonym: "D-tyrosinate(1-)" RELATED [jcbn]
synonym: "D-tyrosine monoanion" RELATED [jcbn]
synonym: "hydrogen D-tyrosinate" EXACT IUPAC:NAME [IUPAC]
synonym: "hydrogen D-tyrosinate" RELATED IUPAC:NAME [iupac]
xref: gmelin:1484464 {source="gmelin"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:32784 ! tyrosinate(1-)
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0018033 CHEBI:28479 ! is deprotonated form of D-tyrosine
relationship: RO:0018034 CHEBI:32774 ! is protonated form of D-tyrosinate(2-)
relationship: RO:0018039 CHEBI:32760 ! is enantiomer of L-tyrosinate(1-)
[Term]
id: CHEBI:32774
name: D-tyrosinate(2-)
def: "The D-enantiomer of tyrosinate(2−)." []
subset: 3:STAR
synonym: "(2R)-2-amino-3-(4-oxidophenyl)propanoate" RELATED [iupac]
synonym: "D-tyrosinate" EXACT IUPAC:NAME [IUPAC]
synonym: "D-tyrosinate" RELATED IUPAC:NAME [iupac]
synonym: "D-tyrosinate(2-)" RELATED [jcbn]
synonym: "D-tyrosine dianion" RELATED [jcbn]
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:32785 ! tyrosinate(2-)
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0018033 CHEBI:32773 ! is deprotonated form of D-tyrosinate(1-)
relationship: RO:0018039 CHEBI:32761 ! is enantiomer of L-tyrosinate(2-)
[Term]
id: CHEBI:32775
name: D-tyrosinium
def: "An optically active form of tyrosinium having D-configuration." []
subset: 3:STAR
synonym: "(1R)-1-carboxy-2-(4-hydroxyphenyl)ethanaminium" RELATED [iupac]
synonym: "D-tyrosine cation" RELATED [jcbn]
synonym: "D-tyrosinium" EXACT IUPAC:NAME [IUPAC]
synonym: "D-tyrosinium" RELATED IUPAC:NAME [iupac]
xref: gmelin:364976 {source="gmelin"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:32786 ! tyrosinium
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0018034 CHEBI:28479 ! is protonated form of D-tyrosine
relationship: RO:0018039 CHEBI:32762 ! is enantiomer of L-tyrosinium
[Term]
id: CHEBI:32784
name: tyrosinate(1-)
def: "An α-amino-acid anion that is the conjugate base of tyrosine, arising from deprotonation of the carboxy group." []
subset: 3:STAR
synonym: "2-amino-3-(4-hydroxyphenyl)propanoate" RELATED [iupac]
synonym: "hydrogen tyrosinate" EXACT IUPAC:NAME [IUPAC]
synonym: "hydrogen tyrosinate" RELATED IUPAC:NAME [iupac]
synonym: "tyrosinate(1-)" RELATED [jcbn]
synonym: "tyrosine anion" RELATED [jcbn]
xref: beilstein:3548387 {source="beilstein"}
xref: beilstein:4139515 {source="beilstein"}
xref: gmelin:329372 {source="gmelin"}
is_a: CHEBI:33558 ! alpha-amino-acid anion
relationship: RO:0018033 CHEBI:18186 ! is deprotonated form of tyrosine
relationship: RO:0018034 CHEBI:32785 ! is protonated form of tyrosinate(2-)
[Term]
id: CHEBI:32785
name: tyrosinate(2-)
subset: 3:STAR
synonym: "2-amino-3-(4-oxidophenyl)propanoate" RELATED [iupac]
synonym: "tyrosinate" EXACT IUPAC:NAME [IUPAC]
synonym: "tyrosinate" RELATED IUPAC:NAME [iupac]
synonym: "tyrosinate(2-)" RELATED [jcbn]
synonym: "tyrosine dianion" RELATED [jcbn]
is_a: CHEBI:33558 ! alpha-amino-acid anion
relationship: RO:0018033 CHEBI:32784 ! is deprotonated form of tyrosinate(1-)
[Term]
id: CHEBI:32786
name: tyrosinium
def: "An α-amino-acid cation that is the conjugate acid of tyrosine, arising from protonation of the amino group." []
subset: 3:STAR
synonym: "1-carboxy-2-(4-hydroxyphenyl)ethanaminium" RELATED [iupac]
synonym: "tyrosine cation" RELATED [jcbn]
synonym: "tyrosinium" EXACT IUPAC:NAME [IUPAC]
synonym: "tyrosinium" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:33719 ! alpha-amino-acid cation
relationship: RO:0018034 CHEBI:18186 ! is protonated form of tyrosine
[Term]
id: CHEBI:32789
name: tyrosine residue
subset: 3:STAR
synonym: "tyrosine acid residue" RELATED [jcbn]
synonym: "tyrosine residue" RELATED [jcbn]
synonym: "tyrosyl" RELATED [chebi]
is_a: CHEBI:33710 ! alpha-amino-acid residue
relationship: RO:0018037 CHEBI:18186 ! is substitutent group from tyrosine
[Term]
id: CHEBI:32952
name: amine
alt_id: CHEBI:13814
alt_id: CHEBI:22474
alt_id: CHEBI:2641
def: "A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." []
subset: 3:STAR
synonym: "Amin" RELATED [chebi]
synonym: "Amine" RELATED [kegg.compound]
synonym: "amines" EXACT IUPAC:NAME [IUPAC]
synonym: "amines" RELATED IUPAC:NAME [iupac]
synonym: "Substituted amine" RELATED [kegg.compound]
xref: kegg.compound:C00706 {source="kegg.compound"}
is_a: CHEBI:50047 ! organic amino compound
[Term]
id: CHEBI:32988
name: amide
alt_id: CHEBI:22473
alt_id: CHEBI:2633
def: "An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l ≠ 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." []
subset: 3:STAR
synonym: "Amide" EXACT [KEGG_COMPOUND]
synonym: "Amide" RELATED [kegg.compound]
synonym: "amides" EXACT IUPAC:NAME [IUPAC]
synonym: "amides" RELATED IUPAC:NAME [iupac]
xref: kegg.compound:C00241 {source="kegg.compound"}
is_a: CHEBI:51143 ! nitrogen molecular entity
[Term]
id: CHEBI:3306
name: calcitonin
def: "A 32-membered heterodetic cyclic peptide comprising the sequence Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2 cyclised by a disulfide bridge between the two Cys residues at positions 1 and 7." []
subset: 3:STAR
synonym: "Calcitonin" RELATED [kegg.compound]
synonym: "calcitonin" RELATED http://purl.obolibrary.org/obo/chebi/INN [chemidplus]
synonym: "Calcitonin, salmon" RELATED [kegg.compound]
synonym: "Cibacalcin" RELATED [kegg.compound]
synonym: "cyclo-[Cys-Ser-Asn-Leu-Ser-Thr-Cys]-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2" RELATED [chebi]
synonym: "N-{[(4R,7S,10S,13S,16S,19S,22R)-22-amino-16-(2-amino-2-oxoethyl)-7-[(1R)-1-hydroxyethyl]-10,19-bis(hydroxymethyl)-13-isobutyl-6,9,12,15,18,21-hexaoxo-1,2-dithia-5,8,11,14,17,20-hexaazacyclotricosan-4-yl]carbonyl}-L-valyl-L-leucylglycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-alpha-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-L-threonyl-L-asparaginyl-L-threonylglycyl-L-serylglycyl-L-threonyl-L-prolinamide" EXACT IUPAC:NAME [IUPAC]
synonym: "N-{[(4R,7S,10S,13S,16S,19S,22R)-22-amino-16-(2-amino-2-oxoethyl)-7-[(1R)-1-hydroxyethyl]-10,19-bis(hydroxymethyl)-13-isobutyl-6,9,12,15,18,21-hexaoxo-1,2-dithia-5,8,11,14,17,20-hexaazacyclotricosan-4-yl]carbonyl}-L-valyl-L-leucylglycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-alpha-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-L-threonyl-L-asparaginyl-L-threonylglycyl-L-serylglycyl-L-threonyl-L-prolinamide" RELATED IUPAC:NAME [iupac]
synonym: "Salmon calcitonin" RELATED [chemidplus]
synonym: "Salmon calcitonin-(1-32)" RELATED [chemidplus]
synonym: "Salmotonin" RELATED [drugbank]
synonym: "Thyrocalcitonin (salmon)" RELATED [chemidplus]
xref: cas:47931-85-1 {source="cas"}
xref: cas:9007-12-9 {source="cas"}
xref: drugbank:DB00017 {source="drugbank"}
xref: drugcentral:2989 {source="drugcentral"}
xref: kegg.compound:C06865 {source="kegg.compound"}
xref: kegg.drug:D00249 {source="kegg.drug"}
xref: reaxys:8186880 {source="reaxys"}
xref: wikipedia.en:Calcitonin {source="wikipedia.en"}
is_a: CHEBI:15841 ! polypeptide
is_a: CHEBI:24533 ! heterodetic cyclic peptide
is_a: CHEBI:25905 ! peptide hormone
relationship: RO:0000087 CHEBI:25212 ! has role metabolite
relationship: RO:0000087 CHEBI:50646 ! has role bone density conservation agent
[Term]
id: CHEBI:3311
name: calcium carbonate
def: "A calcium salt with formula CCaO3." []
subset: 3:STAR
synonym: "CaCO3" RELATED [iupac]
synonym: "Calcium carbonate" RELATED [kegg.compound]
synonym: "calcium carbonate" EXACT IUPAC:NAME [IUPAC]
synonym: "calcium carbonate" RELATED IUPAC:NAME [iupac]
synonym: "calcium carbonate (1:1)" RELATED [chemidplus]
synonym: "calcium trioxidocarbonate" EXACT IUPAC:NAME [IUPAC]
synonym: "calcium trioxidocarbonate" RELATED IUPAC:NAME [iupac]
synonym: "Calciumcarbonat" RELATED [chebi]
synonym: "carbonate de calcium" RELATED [chebi]
synonym: "carbonato de calcio" RELATED [chebi]
synonym: "carbonic acid calcium salt (1:1)" RELATED [chemidplus]
synonym: "E 170" RELATED [chebi]
synonym: "Kalziumkarbonat" RELATED [chebi]
synonym: "kohlensaurer Kalk" RELATED [chebi]
synonym: "Precipitated calcium carbonate" RELATED [kegg.compound]
xref: bpdb:108 {source="bpdb"}
xref: cas:471-34-1 {source="cas"}
xref: drugbank:DB06724 {source="drugbank"}
xref: kegg.compound:C08129 {source="kegg.compound"}
xref: kegg.drug:D00932 {source="kegg.drug"}
xref: ppdb:108 {source="ppdb"}
xref: reaxys:8008338 {source="reaxys"}
xref: wikipedia.en:Calcium_carbonate {source="wikipedia.en"}
is_a: CHEBI:190295 ! inorganic calcium salt
is_a: CHEBI:35156 ! calcium salt
is_a: CHEBI:46721 ! carbonate salt
is_a: CHEBI:64708 ! one-carbon compound
relationship: RO:0000087 CHEBI:33287 ! has role fertilizer
relationship: RO:0000087 CHEBI:65265 ! has role antacid
relationship: RO:0000087 CHEBI:77182 ! has role food colouring
relationship: RO:0000087 CHEBI:77960 ! has role food firming agent
[Term]
id: CHEBI:33232
name: application
def: "Intended use of the molecular entity or part thereof by humans." []
subset: 3:STAR
is_a: CHEBI:50906 ! role
[Term]
id: CHEBI:33233
name: fundamental particle
def: "A particle not known to have substructure." []
subset: 3:STAR
synonym: "elementary particle" EXACT IUPAC:NAME [IUPAC]
synonym: "elementary particle" RELATED IUPAC:NAME [iupac]
synonym: "elementary particles" RELATED [chebi]
is_a: CHEBI:36342 ! subatomic particle
[Term]
id: CHEBI:33238
name: monoatomic entity
def: "A monoatomic entity is a molecular entity consisting of a single atom." []
subset: 3:STAR
synonym: "atomic entity" RELATED [chebi]
synonym: "monoatomic entities" RELATED [chebi]
is_a: CHEBI:33259 ! elemental molecular entity
[Term]
id: CHEBI:33241
name: oxoacid derivative
subset: 3:STAR
synonym: "oxoacid derivatives" RELATED [chebi]
is_a: CHEBI:37577 ! heteroatomic molecular entity
relationship: RO:0018038 CHEBI:24833 ! has functional parent oxoacid
[Term]
id: CHEBI:33242
name: inorganic hydride
subset: 3:STAR
synonym: "inorganic hydrides" RELATED [chebi]
is_a: CHEBI:24835 ! inorganic molecular entity
is_a: CHEBI:33692 ! hydrides
[Term]
id: CHEBI:33245
name: organic fundamental parent
def: "An organic fundamental parent is a structure used as a basis for substitutive names in organic nomenclature, containing, in addition to one or more hydrogen atoms, a single atom of an element, a number of atoms (alike or different) linked together to form an unbranched chain, a monocyclic or polycyclic ring system, or a ring assembly or ring/chain system." []
subset: 3:STAR
synonym: "organic fundamental parents" RELATED [chebi]
synonym: "organic parent hydrides" RELATED [chebi]
is_a: CHEBI:37175 ! organic hydride
is_a: CHEBI:50860 ! organic molecular entity
[Term]
id: CHEBI:33246
name: inorganic group
def: "Any substituent group which does not contain carbon." []
subset: 3:STAR
synonym: "inorganic groups" RELATED [chebi]
is_a: CHEBI:24433 ! group
[Term]
id: CHEBI:33247
name: organic group
def: "Any substituent group or skeleton containing carbon." []
subset: 3:STAR
synonym: "organic groups" RELATED [chebi]
is_a: CHEBI:24433 ! group
relationship: RO:0018033 CHEBI:64769 ! is deprotonated form of organic cationic group
relationship: RO:0018034 CHEBI:64775 ! is protonated form of organic anionic group
[Term]
id: CHEBI:33249
name: organyl group
def: "Any organic substituent group, regardless of functional type, having one free valence at a carbon atom." []
subset: 3:STAR
synonym: "groupe organyle" RELATED [iupac]
synonym: "grupo organilo" RELATED [iupac]
synonym: "grupos organilo" RELATED [iupac]
synonym: "organyl group" EXACT IUPAC:NAME [IUPAC]
synonym: "organyl group" RELATED IUPAC:NAME [iupac]
synonym: "organyl groups" EXACT IUPAC:NAME [IUPAC]
synonym: "organyl groups" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:51447 ! organic univalent group
[Term]
id: CHEBI:33250
name: atom
alt_id: CHEBI:22671
alt_id: CHEBI:23907
def: "A chemical entity constituting the smallest component of an element having the chemical properties of the element." []
subset: 3:STAR
synonym: "atom" EXACT IUPAC:NAME [IUPAC]
synonym: "atom" RELATED IUPAC:NAME [iupac]
synonym: "atome" RELATED [iupac]
synonym: "atomo" RELATED [iupac]
synonym: "atoms" RELATED [chebi]
synonym: "atomus" RELATED [chebi]
synonym: "element" RELATED [chebi]
synonym: "elements" RELATED [chebi]
is_a: CHEBI:24431 ! chemical entity
relationship: has_part CHEBI:10545 ! electron
relationship: has_part CHEBI:33252 ! atomic nucleus
[Term]
id: CHEBI:33251
name: monoatomic hydrogen
subset: 3:STAR
synonym: "atomic hydrogen" RELATED [chebi]
is_a: CHEBI:33238 ! monoatomic entity
is_a: CHEBI:33260 ! elemental hydrogen
[Term]
id: CHEBI:33252
name: atomic nucleus
def: "A nucleus is the positively charged central portion of an atom, excluding the orbital electrons." []
subset: 3:STAR
synonym: "Atomkern" RELATED [chebi]
synonym: "Kern" RELATED [chebi]
synonym: "noyau" RELATED [iupac]
synonym: "noyau atomique" RELATED [chebi]
synonym: "nuclei" RELATED [chebi]
synonym: "nucleo" RELATED [iupac]
synonym: "nucleo atomico" RELATED [chebi]
synonym: "nucleus" EXACT IUPAC:NAME [IUPAC]
synonym: "nucleus" RELATED IUPAC:NAME [iupac]
synonym: "nucleus atomi" RELATED [chebi]
is_a: CHEBI:36347 ! nuclear particle
relationship: has_part CHEBI:24636 ! proton
relationship: has_part CHEBI:33253 ! nucleon
property_value: editor_note "Some people may be uncomfortable calling every proton an atomic nucleus" xsd:string
property_value: editor_note "This is equivalent to CHEBI:33252" xsd:string
[Term]
id: CHEBI:33253
name: nucleon
def: "Heavy nuclear particle: proton or neutron." []
subset: 3:STAR
synonym: "nucleon" EXACT IUPAC:NAME [IUPAC]
synonym: "nucleon" RELATED IUPAC:NAME [iupac]
synonym: "nucleons" RELATED [chebi]
synonym: "Nukleon" RELATED [chebi]
synonym: "Nukleonen" RELATED [chebi]
is_a: CHEBI:36339 ! baryon
is_a: CHEBI:36347 ! nuclear particle
[Term]
id: CHEBI:33256
name: primary amide
def: "A derivative of an oxoacid RkE(=O)l(OH)m (l ≠ 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." []
subset: 3:STAR
synonym: "primary amide" RELATED [iupac]
synonym: "primary amides" EXACT IUPAC:NAME [IUPAC]
synonym: "primary amides" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:32988 ! amide
[Term]
id: CHEBI:33259
name: elemental molecular entity
def: "A molecular entity all atoms of which have the same atomic number." []
subset: 3:STAR
synonym: "homoatomic entity" RELATED [chebi]
synonym: "homoatomic molecular entities" RELATED [chebi]
synonym: "homoatomic molecular entity" RELATED [chebi]
is_a: CHEBI:23367 ! molecular entity
[Term]
id: CHEBI:33260
name: elemental hydrogen
subset: 3:STAR
is_a: CHEBI:24835 ! inorganic molecular entity
is_a: CHEBI:33259 ! elemental molecular entity
is_a: CHEBI:33608 ! hydrogen molecular entity
[Term]
id: CHEBI:33262
name: elemental oxygen
subset: 3:STAR
is_a: CHEBI:24835 ! inorganic molecular entity
is_a: CHEBI:25806 ! oxygen molecular entity
is_a: CHEBI:33259 ! elemental molecular entity
[Term]
id: CHEBI:33263
name: diatomic oxygen
subset: 3:STAR
is_a: CHEBI:33262 ! elemental oxygen
[Term]
id: CHEBI:33273
name: polyatomic anion
def: "An anion consisting of more than one atom." []
subset: 3:STAR
synonym: "polyatomic anions" RELATED [chebi]
is_a: CHEBI:22563 ! anion
is_a: CHEBI:36358 ! polyatomic ion
[Term]
id: CHEBI:33280
name: molecular messenger
subset: 3:STAR
synonym: "chemical messenger" RELATED [chebi]
is_a: CHEBI:24432 ! biological role
[Term]
id: CHEBI:33281
name: antimicrobial agent
alt_id: CHEBI:22582
def: "A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans." []
subset: 3:STAR
synonym: "antibiotic" RELATED [chebi]
synonym: "antibiotics" RELATED [chebi]
synonym: "Antibiotika" RELATED [chebi]
synonym: "Antibiotikum" RELATED [chebi]
synonym: "antibiotique" RELATED [iupac]
synonym: "antimicrobial" RELATED [chebi]
synonym: "antimicrobial agents" RELATED [chebi]
synonym: "antimicrobials" RELATED [chebi]
synonym: "microbicide" RELATED [chebi]
synonym: "microbicides" RELATED [chebi]
xref: pubmed:12964249 {source="pubmed"}
xref: pubmed:22117953 {source="pubmed"}
xref: pubmed:22439833 {source="pubmed"}
xref: pubmed:22849268 {source="pubmed"}
xref: pubmed:22849276 {source="pubmed"}
xref: pubmed:22958833 {source="pubmed"}
is_a: CHEBI:24432 ! biological role
[Term]
id: CHEBI:33282
name: antibacterial agent
def: "A substance (or active part thereof) that kills or slows the growth of bacteria." []
subset: 3:STAR
synonym: "antibacterial agents" RELATED [chebi]
synonym: "antibacterials" RELATED [chebi]
synonym: "bactericide" RELATED [chebi]
synonym: "bactericides" RELATED [chebi]
is_a: CHEBI:33281 ! antimicrobial agent
[Term]
id: CHEBI:33284
name: nutrient
def: "A nutrient is a food component that an organism uses to survive and grow." []
subset: 3:STAR
synonym: "nutrients" RELATED [chebi]
is_a: CHEBI:78295 ! food component
[Term]
id: CHEBI:33285
name: heteroorganic entity
def: "A heteroorganic entity is an organic molecular entity in which carbon atoms or organic groups are bonded directly to one or more heteroatoms." []
subset: 3:STAR
synonym: "heteroorganic entities" RELATED [chebi]
synonym: "organoelement compounds" RELATED [chebi]
is_a: CHEBI:50860 ! organic molecular entity
[Term]
id: CHEBI:33286
name: agrochemical
def: "An agrochemical is a substance that is used in agriculture or horticulture." []
subset: 3:STAR
synonym: "agrichemical" RELATED [chebi]
synonym: "agrichemicals" RELATED [chebi]
synonym: "agricultural chemicals" RELATED [chebi]
synonym: "agrochemicals" RELATED [chebi]
xref: wikipedia.en:Agrochemical {source="wikipedia.en"}
is_a: CHEBI:33232 ! application
[Term]
id: CHEBI:33287
name: fertilizer
def: "A fertilizer is any substance that is added to soil or water to assist the growth of plants." []
subset: 3:STAR
synonym: "fertiliser" RELATED [chebi]
synonym: "fertilizers" RELATED [chebi]
is_a: CHEBI:33286 ! agrochemical
[Term]
id: CHEBI:33290
name: food
def: "A physiological role played by any substance of either plant, animal or artificial origin which contains essential body nutrients that can be ingested by an organism to provide energy, promote growth, and maintain the processes of life." []
subset: 3:STAR
synonym: "food material" RELATED [chebi]
synonym: "food materials" RELATED [chebi]
synonym: "food role" RELATED [chebi]
synonym: "foods" RELATED [chebi]
synonym: "foodstuff" RELATED [chebi]
synonym: "foodstuffs" RELATED [chebi]
is_a: CHEBI:52211 ! physiological role
relationship: has_part CHEBI:78295 ! food component
[Term]
id: CHEBI:33295
name: diagnostic agent
def: "A substance administered to aid diagnosis of a disease." []
subset: 3:STAR
synonym: "diagnostic aid" RELATED [chebi]
is_a: CHEBI:52217 ! pharmaceutical
[Term]
id: CHEBI:33296
name: alkali metal molecular entity
def: "A molecular entity containing one or more atoms of an alkali metal." []
subset: 3:STAR
synonym: "alkali metal molecular entities" RELATED [chebi]
is_a: CHEBI:33674 ! s-block molecular entity
relationship: has_part CHEBI:22314 ! alkali metal atom
[Term]
id: CHEBI:33299
name: alkaline earth molecular entity
def: "An alkaline earth molecular entity is a molecular entity containing one or more atoms of an alkaline earth metal." []
subset: 3:STAR
synonym: "alkaline earth compounds" RELATED [chebi]
synonym: "alkaline earth molecular entities" RELATED [chebi]
synonym: "alkaline earth molecular entity" RELATED [chebi]
synonym: "alkaline-earth compounds" RELATED [chebi]
is_a: CHEBI:33674 ! s-block molecular entity
relationship: has_part CHEBI:22313 ! alkaline earth metal atom
[Term]
id: CHEBI:33300
name: pnictogen
def: "Any p-block element atom that is in group 15 of the periodic table: nitrogen, phosphorus, arsenic, antimony and bismuth." []
subset: 3:STAR
synonym: "group 15 elements" RELATED [chebi]
synonym: "group V elements" RELATED [chebi]
synonym: "nitrogenoideos" RELATED [chebi]
synonym: "nitrogenoides" RELATED [chebi]
synonym: "pnictogene" RELATED [chebi]
synonym: "pnictogenes" RELATED [chebi]
synonym: "pnictogens" EXACT IUPAC:NAME [IUPAC]
synonym: "pnictogens" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:33560 ! p-block element atom
[Term]
id: CHEBI:33302
name: pnictogen molecular entity
def: "A p-block molecular entity containing any pnictogen." []
subset: 3:STAR
synonym: "pnictogen molecular entities" RELATED [chebi]
synonym: "pnictogen molecular entity" RELATED [chebi]
is_a: CHEBI:33675 ! p-block molecular entity
relationship: has_part CHEBI:33300 ! pnictogen
[Term]
id: CHEBI:33303
name: chalcogen
def: "Any p-block element belonging to the group 16 family of the periodic table." []
subset: 3:STAR
synonym: "anfigeno" RELATED [chebi]
synonym: "anfigenos" RELATED [chebi]
synonym: "calcogeno" RELATED [chebi]
synonym: "calcogenos" RELATED [chebi]
synonym: "chalcogen" EXACT IUPAC:NAME [IUPAC]
synonym: "chalcogen" RELATED IUPAC:NAME [iupac]
synonym: "chalcogene" RELATED [chebi]
synonym: "chalcogenes" RELATED [chebi]
synonym: "chalcogens" EXACT IUPAC:NAME [IUPAC]
synonym: "chalcogens" RELATED IUPAC:NAME [iupac]
synonym: "Chalkogen" RELATED [chebi]
synonym: "Chalkogene" RELATED [chebi]
synonym: "group 16 elements" RELATED [chebi]
synonym: "group VI elements" RELATED [chebi]
xref: pubmed:17084588 {source="pubmed"}
is_a: CHEBI:33560 ! p-block element atom
[Term]
id: CHEBI:33304
name: chalcogen molecular entity
def: "Any p-block molecular entity containing a chalcogen." []
subset: 3:STAR
synonym: "chalcogen compounds" RELATED [chebi]
synonym: "chalcogen molecular entities" RELATED [chebi]
synonym: "chalcogen molecular entity" RELATED [chebi]
is_a: CHEBI:33675 ! p-block molecular entity
relationship: has_part CHEBI:33303 ! chalcogen
[Term]
id: CHEBI:33306
name: carbon group element atom
subset: 3:STAR
synonym: "carbon group element" RELATED [chebi]
synonym: "carbon group elements" RELATED [chebi]
synonym: "carbonoides" RELATED [chebi]
synonym: "cristallogene" RELATED [chebi]
synonym: "cristallogenes" RELATED [chebi]
synonym: "group 14 elements" EXACT IUPAC:NAME [IUPAC]
synonym: "group 14 elements" RELATED IUPAC:NAME [iupac]
synonym: "group IV elements" RELATED [chebi]
is_a: CHEBI:33560 ! p-block element atom
[Term]
id: CHEBI:33308
name: carboxylic ester
alt_id: CHEBI:13204
alt_id: CHEBI:23028
alt_id: CHEBI:3408
def: "An ester of a carboxylic acid, R1C(=O)OR2, where R1 = H or organyl and R2 = organyl." []
subset: 3:STAR
synonym: "a carboxylic ester" RELATED [uniprot_ft]
synonym: "carboxylic acid esters" RELATED [chebi]
synonym: "Carboxylic ester" RELATED [kegg.compound]
synonym: "carboxylic esters" EXACT IUPAC:NAME [IUPAC]
synonym: "carboxylic esters" RELATED IUPAC:NAME [iupac]
xref: kegg.compound:C02391 {source="kegg.compound"}
xref: wikipedia.en:Ester {source="wikipedia.en"}
is_a: CHEBI:35701 ! ester
is_a: CHEBI:36586 ! carbonyl compound
[Term]
id: CHEBI:33318
name: main group element atom
def: "An atom belonging to one of the main groups (found in the s- and p- blocks) of the periodic table." []
subset: 3:STAR
synonym: "Hauptgruppenelement" RELATED [chebi]
synonym: "Hauptgruppenelemente" RELATED [chebi]
synonym: "main group element" RELATED [chebi]
synonym: "main group elements" EXACT IUPAC:NAME [IUPAC]
synonym: "main group elements" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:33250 ! atom
[Term]
id: CHEBI:33356
name: iron group element atom
subset: 3:STAR
synonym: "group 8 elements" EXACT IUPAC:NAME [IUPAC]
synonym: "group 8 elements" RELATED IUPAC:NAME [iupac]
synonym: "iron group element" RELATED [chebi]
synonym: "iron group elements" RELATED [chebi]
is_a: CHEBI:33561 ! d-block element atom
[Term]
id: CHEBI:33402
name: sulfur oxoacid
subset: 3:STAR
synonym: "oxoacids of sulfur" RELATED [chebi]
synonym: "sulfur oxoacids" RELATED [chebi]
is_a: CHEBI:26835 ! sulfur molecular entity
is_a: CHEBI:33484 ! chalcogen oxoacid
[Term]
id: CHEBI:33408
name: pnictogen oxoacid
subset: 3:STAR
synonym: "pnictogen oxoacids" RELATED [chebi]
is_a: CHEBI:24833 ! oxoacid
is_a: CHEBI:33302 ! pnictogen molecular entity
relationship: RO:0000087 CHEBI:138103 ! has role inorganic acid
[Term]
id: CHEBI:33424
name: sulfur oxoacid derivative
subset: 3:STAR
synonym: "sulfur oxoacid derivative" RELATED [chebi]
synonym: "sulfur oxoacid derivatives" RELATED [chebi]
is_a: CHEBI:26835 ! sulfur molecular entity
is_a: CHEBI:33241 ! oxoacid derivative
[Term]
id: CHEBI:33447
name: phospho sugar
alt_id: CHEBI:15132
alt_id: CHEBI:16442
alt_id: CHEBI:25406
alt_id: CHEBI:26086
alt_id: CHEBI:9320
def: "Any monosaccharide containing an alcoholic hydroxy group esterified with phosphoric acid." []
subset: 3:STAR
synonym: "monosaccharide phosphates" RELATED [chebi]
synonym: "phospho sugar" RELATED [chebi]
synonym: "phospho sugars" RELATED [chebi]
synonym: "phosphorylated sugar" RELATED [chebi]
synonym: "phosphorylated sugars" RELATED [chebi]
synonym: "phosphosugar" RELATED [chebi]
synonym: "phosphosugars" RELATED [chebi]
xref: kegg.compound:C00934 {source="kegg.compound"}
xref: pubmed:18186488 {source="pubmed"}
is_a: CHEBI:26816 ! carbohydrate phosphate
is_a: CHEBI:63367 ! monosaccharide derivative
[Term]
id: CHEBI:33452
name: benzylic group
def: "Arylmethyl groups and derivatives formed by substitution: ArCR2‒." []
subset: 3:STAR
synonym: "benzylic group" RELATED [iupac]
synonym: "benzylic groups" EXACT IUPAC:NAME [IUPAC]
synonym: "benzylic groups" RELATED IUPAC:NAME [chebi, iupac]
synonym: "groupe benzylique" RELATED [iupac]
is_a: CHEBI:33249 ! organyl group
[Term]
id: CHEBI:33457
name: phosphorus oxoacid
def: "A pnictogen oxoacid which contains phosphorus and oxygen, at least one hydrogen atom bound to oxygen, and forms an ion by the loss of one or more protons." []
subset: 3:STAR
synonym: "oxoacids of phosphorus" RELATED [chebi]
synonym: "Oxosaeure des Phosphors" RELATED [chebi]
synonym: "phosphorus oxoacid" RELATED [chebi]
synonym: "phosphorus oxoacids" RELATED [chebi]
is_a: CHEBI:33408 ! pnictogen oxoacid
is_a: CHEBI:36360 ! phosphorus oxoacids and derivatives
[Term]
id: CHEBI:33459
name: pnictogen oxoanion
subset: 3:STAR
synonym: "pnictogen oxoanion" RELATED [chebi]
synonym: "pnictogen oxoanions" RELATED [chebi]
is_a: CHEBI:33302 ! pnictogen molecular entity
is_a: CHEBI:35406 ! oxoanion
[Term]
id: CHEBI:33461
name: phosphorus oxoanion
subset: 3:STAR
synonym: "oxoanions of phosphorus" RELATED [chebi]
synonym: "phosphorus oxoanion" RELATED [chebi]
synonym: "phosphorus oxoanions" RELATED [chebi]
is_a: CHEBI:24834 ! inorganic anion
is_a: CHEBI:26082 ! phosphorus molecular entity
is_a: CHEBI:33459 ! pnictogen oxoanion
[Term]
id: CHEBI:33482
name: sulfur oxoanion
subset: 3:STAR
synonym: "oxoanions of sulfur" RELATED [chebi]
synonym: "sulfur oxoanion" RELATED [chebi]
synonym: "sulfur oxoanions" RELATED [chebi]
is_a: CHEBI:26835 ! sulfur molecular entity
is_a: CHEBI:33485 ! chalcogen oxoanion
[Term]
id: CHEBI:33484
name: chalcogen oxoacid
subset: 3:STAR
synonym: "chalcogen oxoacid" RELATED [chebi]
synonym: "chalcogen oxoacids" RELATED [chebi]
is_a: CHEBI:24833 ! oxoacid
relationship: RO:0000087 CHEBI:138103 ! has role inorganic acid
[Term]
id: CHEBI:33485
name: chalcogen oxoanion
subset: 3:STAR
synonym: "chalcogen oxoanion" RELATED [chebi]
synonym: "chalcogen oxoanions" RELATED [chebi]
is_a: CHEBI:35406 ! oxoanion
[Term]
id: CHEBI:33497
name: transition element molecular entity
def: "A molecular entity containing one or more atoms of a transition element." []
subset: 3:STAR
synonym: "transition element molecular entities" RELATED [chebi]
synonym: "transition metal molecular entity" RELATED [chebi]
is_a: CHEBI:23367 ! molecular entity
relationship: has_part CHEBI:27081 ! transition element atom
[Term]
id: CHEBI:33504
name: alkali metal cation
subset: 3:STAR
synonym: "alkali metal cations" RELATED [chebi]
is_a: CHEBI:25213 ! metal cation
[Term]
id: CHEBI:33513
name: alkaline earth cation
subset: 3:STAR
synonym: "alkaline earth cations" RELATED [chebi]
synonym: "alkaline earth metal cation" RELATED [chebi]
synonym: "alkaline-earth metal cations" RELATED [chebi]
is_a: CHEBI:25213 ! metal cation
is_a: CHEBI:33299 ! alkaline earth molecular entity
[Term]
id: CHEBI:33515
name: transition element cation
subset: 3:STAR
synonym: "transition element cations" RELATED [chebi]
synonym: "transition metal cation" RELATED [chebi]
is_a: CHEBI:25213 ! metal cation
[Term]
id: CHEBI:33521
name: metal atom
alt_id: CHEBI:25217
alt_id: CHEBI:6788
def: "An atom of an element that exhibits typical metallic properties, being typically shiny, with high electrical and thermal conductivity." []
subset: 3:STAR
synonym: "elemental metal" RELATED [chebi]
synonym: "elemental metals" RELATED [chebi]
synonym: "metal element" RELATED [chebi]
synonym: "metal elements" RELATED [chebi]
synonym: "metals" RELATED [chebi]
xref: kegg.compound:C00050 {source="kegg.compound"}
xref: pubmed:21784043 {source="pubmed"}
xref: wikipedia.en:Metal {source="wikipedia.en"}
is_a: CHEBI:33250 ! atom
[Term]
id: CHEBI:33558
name: alpha-amino-acid anion
def: "An amino-acid anion obtained by deprotonation of any α-amino acid." []
subset: 3:STAR
synonym: "alpha-amino acid anion" RELATED [chebi]
synonym: "alpha-amino acid anions" RELATED [chebi]
synonym: "alpha-amino-acid anions" RELATED [chebi]
is_a: CHEBI:37022 ! amino-acid anion
relationship: RO:0018033 CHEBI:33704 ! is deprotonated form of alpha-amino acid
[Term]
id: CHEBI:33559
name: s-block element atom
subset: 3:STAR
synonym: "s-block element" RELATED [chebi]
synonym: "s-block elements" RELATED [chebi]
is_a: CHEBI:33250 ! atom
[Term]
id: CHEBI:33560
name: p-block element atom
def: "Any main group element atom belonging to the p-block of the periodic table." []
subset: 3:STAR
synonym: "p-block element" RELATED [chebi]
synonym: "p-block elements" RELATED [chebi]
is_a: CHEBI:33318 ! main group element atom
[Term]
id: CHEBI:33561
name: d-block element atom
subset: 3:STAR
synonym: "d-block element" RELATED [chebi]
synonym: "d-block elements" RELATED [chebi]
is_a: CHEBI:27081 ! transition element atom
[Term]
id: CHEBI:33563
name: glycolipid
alt_id: CHEBI:24393
alt_id: CHEBI:5476
def: "Any member of class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). Some substances classified as bacterial glycolipids have the sugar part acylated by one or more fatty acids and the glycerol part may be absent." []
subset: 3:STAR
synonym: "a glycolipid" RELATED [uniprot_ft]
synonym: "Glycolipid" RELATED [kegg.compound]
synonym: "glycolipids" EXACT IUPAC:NAME [IUPAC]
synonym: "glycolipids" RELATED IUPAC:NAME [iupac]
xref: kegg.compound:C05005 {source="kegg.compound"}
xref: wikipedia.en:Glycolipids {source="wikipedia.en"}
is_a: CHEBI:35740 ! liposaccharide
[Term]
id: CHEBI:33566
name: catechols
alt_id: CHEBI:134187
alt_id: CHEBI:13628
alt_id: CHEBI:18862
def: "Any compound containing an o-diphenol component." []
subset: 3:STAR
synonym: "1,2-benzenediols" RELATED [chebi]
synonym: "a catechol" RELATED [uniprot_ft]
synonym: "benzene-1,2-diols" RELATED [chebi]
xref: kegg.compound:C15571 {source="kegg.compound"}
is_a: CHEBI:33570 ! benzenediols
[Term]
id: CHEBI:33567
name: catecholamine
alt_id: CHEBI:23056
alt_id: CHEBI:3468
def: "4-(2-Aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution." []
subset: 3:STAR
synonym: "Catecholamine" RELATED [kegg.compound]
synonym: "catecholamines" EXACT IUPAC:NAME [IUPAC]
synonym: "catecholamines" RELATED IUPAC:NAME [chebi, iupac]
xref: kegg.compound:C02012 {source="kegg.compound"}
is_a: CHEBI:25375 ! monoamine molecular messenger
is_a: CHEBI:33566 ! catechols
[Term]
id: CHEBI:33569
name: noradrenaline
def: "A catecholamine in which C-1 of the aminoethyl side-chain is hydroxy-substituted." []
subset: 3:STAR
synonym: "4-(2-amino-1-hydroxyethyl)benzene-1,2-diol" EXACT IUPAC:NAME [IUPAC]
synonym: "4-(2-amino-1-hydroxyethyl)benzene-1,2-diol" RELATED IUPAC:NAME [iupac]
synonym: "noradrenalina" RELATED [chebi]
synonym: "norepinephrine" RELATED [chebi]
xref: beilstein:2210994 {source="beilstein"}
xref: cas:138-65-8 {source="cas"}
xref: gmelin:863925 {source="gmelin"}
xref: lincs.smallmolecule:LSM-5181 {source="lincs.smallmolecule"}
is_a: CHEBI:33567 ! catecholamine
relationship: RO:0000087 CHEBI:76967 ! has role human xenobiotic metabolite
relationship: RO:0018033 CHEBI:166902 ! is deprotonated form of noradrenaline(1+)
[Term]
id: CHEBI:33570
name: benzenediols
alt_id: CHEBI:22705
alt_id: CHEBI:22711
subset: 3:STAR
is_a: CHEBI:33853 ! phenols
[Term]
id: CHEBI:33571
name: (S)-noradrenaline
def: "The S-enantiomer of noradrenaline." []
subset: 3:STAR
synonym: "4-[(1S)-2-amino-1-hydroxyethyl]benzene-1,2-diol" EXACT IUPAC:NAME [IUPAC]
synonym: "4-[(1S)-2-amino-1-hydroxyethyl]benzene-1,2-diol" RELATED IUPAC:NAME [iupac]
xref: lincs.smallmolecule:LSM-37072 {source="lincs.smallmolecule"}
xref: reaxys:2937999 {source="reaxys"}
is_a: CHEBI:33569 ! noradrenaline
relationship: RO:0018033 CHEBI:234420 ! is deprotonated form of (S)-noradrenaline(1+)
relationship: RO:0018039 CHEBI:18357 ! is enantiomer of (R)-noradrenaline
[Term]
id: CHEBI:33575
name: carboxylic acid
alt_id: CHEBI:13428
alt_id: CHEBI:13627
alt_id: CHEBI:23027
def: "A carbon oxoacid acid carrying at least one ‒C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid." []
subset: 3:STAR
synonym: "acide carboxylique" RELATED [iupac]
synonym: "acides carboxyliques" RELATED [iupac]
synonym: "acido carboxilico" RELATED [iupac]
synonym: "acidos carboxilicos" RELATED [iupac]
synonym: "Carbonsaeure" RELATED [chebi]
synonym: "Carbonsaeuren" RELATED [chebi]
synonym: "carboxylic acid" EXACT IUPAC:NAME [IUPAC]
synonym: "carboxylic acid" RELATED IUPAC:NAME [iupac]
synonym: "carboxylic acids" EXACT IUPAC:NAME [IUPAC]
synonym: "carboxylic acids" RELATED IUPAC:NAME [iupac]
synonym: "Karbonsaeure" RELATED [chebi]
synonym: "RC(=O)OH" RELATED [iupac]
xref: pubmed:17147560 {source="pubmed"}
xref: pubmed:18433345 {source="pubmed"}
xref: wikipedia.en:Carboxylic_acid {source="wikipedia.en"}
is_a: CHEBI:35605 ! carbon oxoacid
is_a: CHEBI:36586 ! carbonyl compound
is_a: CHEBI:64709 ! organic acid
relationship: has_part CHEBI:46883 ! carboxy group
relationship: RO:0018034 CHEBI:29067 ! is protonated form of carboxylic acid anion
[Term]
id: CHEBI:33579
name: main group molecular entity
def: "A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table." []
subset: 3:STAR
synonym: "main group compounds" RELATED [chebi]
synonym: "main group molecular entities" RELATED [chebi]
is_a: CHEBI:23367 ! molecular entity
relationship: has_part CHEBI:33318 ! main group element atom
[Term]
id: CHEBI:33582
name: carbon group molecular entity
subset: 3:STAR
synonym: "carbon group molecular entities" RELATED [chebi]
synonym: "carbon group molecular entity" RELATED [chebi]
is_a: CHEBI:33675 ! p-block molecular entity
relationship: has_part CHEBI:33306 ! carbon group element atom
[Term]
id: CHEBI:33595
name: cyclic compound
def: "Any molecule that consists of a series of atoms joined together to form a ring." []
subset: 3:STAR
synonym: "cyclic compounds" RELATED [chebi]
xref: wikipedia.en:Cyclic_compound {source="wikipedia.en"}
is_a: CHEBI:25367 ! molecule
[Term]
id: CHEBI:33597
name: homocyclic compound
def: "A cyclic compound having as ring members atoms of the same element only." []
subset: 3:STAR
synonym: "homocyclic compound" EXACT IUPAC:NAME [IUPAC]
synonym: "homocyclic compound" RELATED IUPAC:NAME [iupac]
synonym: "homocyclic compounds" EXACT IUPAC:NAME [IUPAC]
synonym: "homocyclic compounds" RELATED IUPAC:NAME [iupac]
synonym: "isocyclic compounds" RELATED [iupac]
is_a: CHEBI:33595 ! cyclic compound
[Term]
id: CHEBI:33598
name: carbocyclic compound
def: "A homocyclic compound in which all of the ring members are carbon atoms." []
subset: 3:STAR
synonym: "carbocycle" RELATED [chebi]
synonym: "carbocyclic compound" EXACT IUPAC:NAME [IUPAC]
synonym: "carbocyclic compound" RELATED IUPAC:NAME [iupac]
synonym: "carbocyclic compounds" EXACT IUPAC:NAME [IUPAC]
synonym: "carbocyclic compounds" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:33597 ! homocyclic compound
is_a: CHEBI:33832 ! organic cyclic compound
[Term]
id: CHEBI:33608
name: hydrogen molecular entity
subset: 3:STAR
synonym: "hydrogen compounds" RELATED [chebi]
synonym: "hydrogen molecular entities" RELATED [chebi]
is_a: CHEBI:33674 ! s-block molecular entity
relationship: has_part CHEBI:49637 ! hydrogen atom
[Term]
id: CHEBI:33635
name: polycyclic compound
subset: 3:STAR
synonym: "polycyclic compounds" RELATED [chebi]
is_a: CHEBI:33595 ! cyclic compound
[Term]
id: CHEBI:33636
name: bicyclic compound
def: "A molecule that features two fused rings." []
subset: 3:STAR
synonym: "bicyclic compounds" RELATED [chebi]
is_a: CHEBI:33595 ! cyclic compound
[Term]
id: CHEBI:33653
name: aliphatic compound
def: "Any acyclic or cyclic, saturated or unsaturated carbon compound, excluding aromatic compounds." []
subset: 3:STAR
synonym: "aliphatic compounds" EXACT IUPAC:NAME [IUPAC]
synonym: "aliphatic compounds" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:50860 ! organic molecular entity
[Term]
id: CHEBI:33655
name: aromatic compound
def: "A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekulé structure) is said to possess aromatic character." []
subset: 3:STAR
synonym: "aromatic compounds" EXACT IUPAC:NAME [IUPAC]
synonym: "aromatic compounds" RELATED IUPAC:NAME [iupac]
synonym: "aromatic molecular entity" EXACT IUPAC:NAME [IUPAC]
synonym: "aromatic molecular entity" RELATED IUPAC:NAME [iupac]
synonym: "aromatics" RELATED [chebi]
synonym: "aromatische Verbindungen" RELATED [chebi]
is_a: CHEBI:33595 ! cyclic compound
[Term]
id: CHEBI:33658
name: arene
def: "Any monocyclic or polycyclic aromatic hydrocarbon." []
subset: 3:STAR
synonym: "arene" EXACT IUPAC:NAME [IUPAC]
synonym: "arene" RELATED IUPAC:NAME [iupac]
synonym: "arenes" EXACT IUPAC:NAME [IUPAC]
synonym: "arenes" RELATED IUPAC:NAME [iupac]
synonym: "aromatic hydrocarbons" RELATED [iupac]
is_a: CHEBI:33659 ! organic aromatic compound
is_a: CHEBI:33663 ! cyclic hydrocarbon
[Term]
id: CHEBI:33659
name: organic aromatic compound
subset: 3:STAR
synonym: "organic aromatic compounds" RELATED [chebi]
is_a: CHEBI:33655 ! aromatic compound
is_a: CHEBI:33832 ! organic cyclic compound
[Term]
id: CHEBI:33661
name: monocyclic compound
subset: 3:STAR
synonym: "monocyclic compounds" RELATED [chebi]
is_a: CHEBI:33595 ! cyclic compound
[Term]
id: CHEBI:33662
name: annulene
def: "A mancude monocyclic hydrocarbon without side chains of the general formula CnHn (n is an even number) or CnHn+1 (n is an odd number). In systematic nomenclature an annulene with seven or more carbon atoms may be named [n]annulene, where n is the number of carbon atoms." []
subset: 3:STAR
synonym: "annulene" EXACT IUPAC:NAME [IUPAC]
synonym: "annulene" RELATED IUPAC:NAME [iupac]
synonym: "annulenes" EXACT IUPAC:NAME [IUPAC]
synonym: "annulenes" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:33664 ! monocyclic hydrocarbon
[Term]
id: CHEBI:33663
name: cyclic hydrocarbon
subset: 3:STAR
synonym: "cyclic hydrocarbon" RELATED [chebi]
synonym: "cyclic hydrocarbons" RELATED [chebi]
is_a: CHEBI:24632 ! hydrocarbon
is_a: CHEBI:33598 ! carbocyclic compound
[Term]
id: CHEBI:33664
name: monocyclic hydrocarbon
subset: 3:STAR
synonym: "monocyclic hydrocarbon" RELATED [chebi]
synonym: "monocyclic hydrocarbons" EXACT IUPAC:NAME [IUPAC]
synonym: "monocyclic hydrocarbons" RELATED IUPAC:NAME [chebi, iupac]
is_a: CHEBI:33663 ! cyclic hydrocarbon
[Term]
id: CHEBI:33670
name: heteromonocyclic compound
subset: 3:STAR
synonym: "heteromonocyclic compound" EXACT IUPAC:NAME [IUPAC]
synonym: "heteromonocyclic compound" RELATED IUPAC:NAME [iupac]
synonym: "heteromonocyclic compounds" EXACT IUPAC:NAME [IUPAC]
synonym: "heteromonocyclic compounds" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:33661 ! monocyclic compound
is_a: CHEBI:5686 ! heterocyclic compound
[Term]
id: CHEBI:33671
name: heteropolycyclic compound
def: "A polycyclic compound in which at least one of the rings contains at least one non-carbon atom." []
subset: 3:STAR
synonym: "heteropolycyclic compounds" EXACT IUPAC:NAME [IUPAC]
synonym: "heteropolycyclic compounds" RELATED IUPAC:NAME [iupac]
synonym: "polyheterocyclic compounds" RELATED [chebi]
is_a: CHEBI:33635 ! polycyclic compound
is_a: CHEBI:5686 ! heterocyclic compound
[Term]
id: CHEBI:33672
name: heterobicyclic compound
def: "A bicyclic compound in which at least one of the rings contains at least one skeletal heteroatom." []
subset: 3:STAR
synonym: "heterobicyclic compounds" EXACT IUPAC:NAME [IUPAC]
synonym: "heterobicyclic compounds" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:33636 ! bicyclic compound
is_a: CHEBI:5686 ! heterocyclic compound
[Term]
id: CHEBI:33674
name: s-block molecular entity
def: "An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element." []
subset: 3:STAR
synonym: "s-block compounds" RELATED [chebi]
synonym: "s-block molecular entities" RELATED [chebi]
synonym: "s-block molecular entity" RELATED [chebi]
is_a: CHEBI:33579 ! main group molecular entity
relationship: has_part CHEBI:33559 ! s-block element atom
[Term]
id: CHEBI:33675
name: p-block molecular entity
def: "A main group molecular entity that contains one or more atoms of a p-block element." []
subset: 3:STAR
synonym: "p-block compounds" RELATED [chebi]
synonym: "p-block molecular entities" RELATED [chebi]
synonym: "p-block molecular entitiy" RELATED [chebi]
is_a: CHEBI:33579 ! main group molecular entity
relationship: has_part CHEBI:33560 ! p-block element atom
[Term]
id: CHEBI:33676
name: d-block molecular entity
def: "A d-block molecular entity is a molecular entity containing one or more atoms of a d-block element." []
subset: 3:STAR
synonym: "d-block compounds" RELATED [chebi]
synonym: "d-block molecular entities" RELATED [chebi]
synonym: "d-block molecular entity" RELATED [chebi]
is_a: CHEBI:33497 ! transition element molecular entity
relationship: has_part CHEBI:33561 ! d-block element atom
[Term]
id: CHEBI:33692
name: hydrides
def: "Hydrides are chemical compounds of hydrogen with other chemical elements." []
subset: 3:STAR
is_a: CHEBI:33608 ! hydrogen molecular entity
is_a: CHEBI:37577 ! heteroatomic molecular entity
[Term]
id: CHEBI:33693
name: oxygen hydride
subset: 3:STAR
synonym: "hydrides of oxygen" RELATED [chebi]
synonym: "oxygen hydride" RELATED [chebi]
synonym: "oxygen hydrides" RELATED [chebi]
is_a: CHEBI:36902 ! chalcogen hydride
[Term]
id: CHEBI:33694
name: biomacromolecule
def: "A macromolecule formed by a living organism." []
subset: 3:STAR
synonym: "biomacromolecules" RELATED [chebi]
synonym: "biopolymer" EXACT IUPAC:NAME [IUPAC]
synonym: "biopolymer" RELATED IUPAC:NAME [iupac]
synonym: "Biopolymere" RELATED [chebi]
synonym: "biopolymers" RELATED [chebi]
is_a: CHEBI:33839 ! macromolecule
is_a: CHEBI:50860 ! organic molecular entity
[Term]
id: CHEBI:33695
name: information biomacromolecule
subset: 3:STAR
synonym: "genetically encoded biomacromolecules" RELATED [chebi]
synonym: "genetically encoded biopolymers" RELATED [chebi]
synonym: "information biomacromolecules" RELATED [chebi]
synonym: "information biopolymers" RELATED [chebi]
synonym: "information macromolecule" RELATED [chebi]
synonym: "information macromolecules" RELATED [chebi]
is_a: CHEBI:33694 ! biomacromolecule
[Term]
id: CHEBI:33696
name: nucleic acid
def: "A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid." []
subset: 3:STAR
synonym: "acide nucleique" RELATED [chebi]
synonym: "acides nucleiques" RELATED [chebi]
synonym: "acido nucleico" RELATED [chebi]
synonym: "acidos nucleicos" RELATED [chebi]
synonym: "NA" RELATED []
synonym: "nucleic acids" EXACT IUPAC:NAME [IUPAC]
synonym: "nucleic acids" RELATED IUPAC:NAME [iupac]
synonym: "Nukleinsaeure" RELATED [chebi]
synonym: "Nukleinsaeuren" RELATED [chebi]
is_a: CHEBI:15986 ! polynucleotide
relationship: has_part CHEBI:33791 ! canonical nucleoside residue
relationship: has_part CHEBI:50297 ! canonical nucleotide residue
[Term]
id: CHEBI:33697
name: ribonucleic acid
def: "High molecular weight, linear polymers, composed of nucleotides containing ribose and linked by phosphodiester bonds; RNA is central to the synthesis of proteins." []
subset: 3:STAR
synonym: "pentosenucleic acids" RELATED [chemidplus]
synonym: "ribonucleic acid" RELATED [iupac]
synonym: "ribonucleic acids" EXACT IUPAC:NAME [IUPAC]
synonym: "ribonucleic acids" RELATED IUPAC:NAME [chebi, iupac]
synonym: "Ribonukleinsaeure" RELATED [chebi]
synonym: "ribose nucleic acid" RELATED [chebi]
synonym: "RNA" RELATED [iupac, uniprot_ft]
synonym: "RNS" RELATED [chebi]
synonym: "yeast nucleic acid" RELATED [chebi]
xref: cas:63231-63-0 {source="cas"}
is_a: CHEBI:33696 ! nucleic acid
relationship: has_part CHEBI:33792 ! canonical ribonucleoside residue
relationship: has_part CHEBI:50299 ! canonical ribonucleotide residue
[Term]
id: CHEBI:33700
name: proteinogenic amino-acid residue
subset: 3:STAR
synonym: "canonical amino-acid residue" RELATED [chebi]
synonym: "canonical amino-acid residues" RELATED [chebi]
synonym: "common amino acid residues" RELATED [chebi]
synonym: "proteinogenic amino-acid residues" RELATED [chebi]
synonym: "standard amino acid residues" RELATED [chebi]
synonym: "standard amino-acid residues" RELATED [chebi]
is_a: CHEBI:33710 ! alpha-amino-acid residue
[Term]
id: CHEBI:33702
name: polyatomic cation
def: "A cation consisting of more than one atom." []
subset: 3:STAR
synonym: "polyatomic cations" RELATED [chebi]
is_a: CHEBI:36358 ! polyatomic ion
is_a: CHEBI:36916 ! cation
[Term]
id: CHEBI:33703
name: amino-acid cation
subset: 3:STAR
synonym: "amino acid cation" RELATED [chebi]
synonym: "amino acid cations" RELATED [chebi]
synonym: "amino-acid cations" RELATED [chebi]
is_a: CHEBI:25697 ! organic cation
is_a: CHEBI:33702 ! polyatomic cation
relationship: RO:0018034 CHEBI:33709 ! is protonated form of amino acid
[Term]
id: CHEBI:33704
name: alpha-amino acid
alt_id: CHEBI:10208
alt_id: CHEBI:13779
alt_id: CHEBI:22442
alt_id: CHEBI:2642
def: "An amino acid in which the amino group is located on the carbon atom at the position α to the carboxy group." []
subset: 3:STAR
synonym: "alpha-amino acid" EXACT IUPAC:NAME [IUPAC]
synonym: "alpha-amino acid" RELATED IUPAC:NAME [iupac]
synonym: "alpha-amino acids" RELATED [chebi, jcbn]
synonym: "alpha-amino carboxylic acids" RELATED [iupac]
synonym: "Amino acid" RELATED [kegg.compound]
synonym: "Amino acids" RELATED [kegg.compound]
xref: kegg.compound:C00045 {source="kegg.compound"}
xref: kegg.compound:C05167 {source="kegg.compound"}
is_a: CHEBI:33709 ! amino acid
relationship: RO:0018033 CHEBI:33719 ! is deprotonated form of alpha-amino-acid cation
relationship: RO:0018034 CHEBI:33558 ! is protonated form of alpha-amino-acid anion
relationship: RO:0018036 CHEBI:78608 ! is tautomer of alpha-amino-acid zwitterion
[Term]
id: CHEBI:33707
name: gamma-amino acid
def: "A non-proteinogenic amino-acid in which the amino group is located on the carbon atom at the position γ to the carboxy group." []
subset: 3:STAR
synonym: "gamma-amino acid" RELATED [chebi]
synonym: "gamma-amino acids" RELATED [chebi]
is_a: CHEBI:83820 ! non-proteinogenic amino acid
relationship: RO:0018034 CHEBI:71666 ! is protonated form of gamma-amino acid anion
[Term]
id: CHEBI:33708
name: amino-acid residue
def: "When two or more amino acids combine to form a peptide, the elements of water are removed, and what remains of each amino acid is called an amino-acid residue." []
subset: 3:STAR
synonym: "amino acid residue" RELATED [chebi]
synonym: "amino acid residues" RELATED [chebi]
synonym: "amino-acid residue" EXACT IUPAC:NAME [IUPAC]
synonym: "amino-acid residue" RELATED IUPAC:NAME [iupac]
synonym: "amino-acid residues" RELATED [jcbn]
is_a: CHEBI:33247 ! organic group
relationship: RO:0018033 CHEBI:58942 ! is deprotonated form of cationic amino-acid residue
relationship: RO:0018034 CHEBI:64898 ! is protonated form of anionic amino-acid residue
relationship: RO:0018037 CHEBI:33709 ! is substitutent group from amino acid
[Term]
id: CHEBI:33709
name: amino acid
alt_id: CHEBI:13815
alt_id: CHEBI:22477
def: "A carboxylic acid containing one or more amino groups." []
subset: 3:STAR
synonym: "amino acids" RELATED [chebi]
synonym: "Aminocarbonsaeure" RELATED [chebi]
synonym: "Aminokarbonsaeure" RELATED [chebi]
synonym: "Aminosaeure" RELATED [chebi]
xref: wikipedia.en:Amino_acid {source="wikipedia.en"}
is_a: CHEBI:33575 ! carboxylic acid
is_a: CHEBI:50047 ! organic amino compound
relationship: RO:0018033 CHEBI:33703 ! is deprotonated form of amino-acid cation
relationship: RO:0018034 CHEBI:37022 ! is protonated form of amino-acid anion
[Term]
id: CHEBI:33710
name: alpha-amino-acid residue
def: "An amino-acid residue derived from an α-amino acid." []
subset: 3:STAR
synonym: "alpha-amino-acid residues" RELATED [chebi]
synonym: "an alpha-amino acid residue" RELATED [uniprot_ft]
is_a: CHEBI:33708 ! amino-acid residue
relationship: RO:0018037 CHEBI:33704 ! is substitutent group from alpha-amino acid
[Term]
id: CHEBI:33719
name: alpha-amino-acid cation
subset: 3:STAR
synonym: "alpha-amino acid cation" RELATED [chebi]
synonym: "alpha-amino acid cations" RELATED [chebi]
synonym: "alpha-amino-acid cations" RELATED [chebi]
is_a: CHEBI:33703 ! amino-acid cation
relationship: RO:0018034 CHEBI:33704 ! is protonated form of alpha-amino acid
[Term]
id: CHEBI:33720
name: carbohydrate acid
subset: 3:STAR
synonym: "carbohydrate acid" RELATED [chebi]
synonym: "carbohydrate acids" RELATED [chebi]
is_a: CHEBI:16646 ! carbohydrate
is_a: CHEBI:33575 ! carboxylic acid
relationship: RO:0018034 CHEBI:33721 ! is protonated form of carbohydrate acid anion
[Term]
id: CHEBI:33721
name: carbohydrate acid anion
subset: 3:STAR
synonym: "carbohydrate acid anion" RELATED [chebi]
synonym: "carbohydrate acid anions" RELATED [chebi]
is_a: CHEBI:29067 ! carboxylic acid anion
relationship: RO:0018033 CHEBI:33720 ! is deprotonated form of carbohydrate acid
[Term]
id: CHEBI:33744
name: iron group molecular entity
subset: 3:STAR
synonym: "iron group molecular entities" RELATED [chebi]
synonym: "iron group molecular entity" RELATED [chebi]
is_a: CHEBI:33676 ! d-block molecular entity
relationship: has_part CHEBI:33356 ! iron group element atom
[Term]
id: CHEBI:33791
name: canonical nucleoside residue
subset: 3:STAR
synonym: "canonical nucleoside residues" RELATED [chebi]
synonym: "common nucleoside residues" RELATED [iubmb]
synonym: "nucleoside residue" RELATED [iubmb]
synonym: "standard nucleoside residues" RELATED [chebi]
is_a: CHEBI:50320 ! nucleoside residue
[Term]
id: CHEBI:33792
name: canonical ribonucleoside residue
subset: 3:STAR
synonym: "canonical ribonucleoside residues" RELATED [chebi]
synonym: "common ribonucleoside residue" RELATED [iubmb]
synonym: "common ribonucleoside residues" RELATED [iubmb]
synonym: "N" RELATED [iubmb]
synonym: "Nuc" RELATED [iubmb]
synonym: "standard ribonucleoside residues" RELATED [chebi]
is_a: CHEBI:33791 ! canonical nucleoside residue
[Term]
id: CHEBI:33793
name: canonical deoxyribonucleoside residue
subset: 3:STAR
synonym: "canonical deoxyribonucleoside residues" RELATED [chebi]
synonym: "common 2'-deoxyribonucleoside residue" RELATED [iubmb]
synonym: "common 2'-deoxyribonucleoside residues" RELATED [iubmb]
synonym: "dN" RELATED [iubmb]
synonym: "dNuc" RELATED [iubmb]
synonym: "standard deoxyribonucleoside residues" RELATED [chebi]
is_a: CHEBI:33791 ! canonical nucleoside residue
[Term]
id: CHEBI:33822
name: organic hydroxy compound
alt_id: CHEBI:64710
def: "An organic compound having at least one hydroxy group attached to a carbon atom." []
subset: 3:STAR
synonym: "hydroxy compounds" EXACT IUPAC:NAME [IUPAC]
synonym: "hydroxy compounds" RELATED IUPAC:NAME [iupac]
synonym: "organic alcohol" RELATED [chebi]
synonym: "organic hydroxy compounds" RELATED [chebi]
is_a: CHEBI:24651 ! hydroxides
is_a: CHEBI:50860 ! organic molecular entity
[Term]
id: CHEBI:33832
name: organic cyclic compound
def: "Any organic molecule that consists of atoms connected in the form of a ring." []
subset: 3:STAR
synonym: "organic cyclic compounds" RELATED [chebi]
is_a: CHEBI:33595 ! cyclic compound
is_a: CHEBI:72695 ! organic molecule
[Term]
id: CHEBI:33833
name: heteroarene
def: "A heterocyclic compound formally derived from an arene by replacement of one or more methine (‒C=) and/or vinylene (‒CH=CH‒) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous π-electron system characteristic of aromatic systems and a number of out-of-plane π-electrons corresponding to the Hückel rule (4n+2)." []
subset: 3:STAR
synonym: "hetarenes" RELATED [iupac]
synonym: "heteroarenes" EXACT IUPAC:NAME [IUPAC]
synonym: "heteroarenes" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:24532 ! organic heterocyclic compound
is_a: CHEBI:33659 ! organic aromatic compound
[Term]
id: CHEBI:33836
name: benzenoid aromatic compound
subset: 3:STAR
synonym: "benzenoid aromatic compounds" RELATED [chebi]
synonym: "benzenoid compound" RELATED [chebi]
is_a: CHEBI:33598 ! carbocyclic compound
is_a: CHEBI:33659 ! organic aromatic compound
[Term]
id: CHEBI:33837
name: conjugated protein
def: "Conjugated protein is a protein that contains a non-peptide component, usually in stoichiometric proportion." []
subset: 3:STAR
synonym: "conjugated proteins" EXACT IUPAC:NAME [IUPAC]
synonym: "conjugated proteins" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:36080 ! protein
[Term]
id: CHEBI:33838
name: nucleoside
alt_id: CHEBI:13661
alt_id: CHEBI:25611
alt_id: CHEBI:7647
def: "An N-glycosyl compound that has both a nucleobase, normally adenine, guanine, xanthine, thymine, cytosine or uracil, and either a ribose or deoxyribose as functional parents." []
subset: 3:STAR
synonym: "a nucleoside" RELATED [uniprot_ft]
synonym: "Nucleoside" RELATED [kegg.compound]
synonym: "nucleosides" EXACT IUPAC:NAME [IUPAC]
synonym: "nucleosides" RELATED IUPAC:NAME [chebi, iupac]
xref: kegg.compound:C00801 {source="kegg.compound"}
xref: wikipedia.en:Nucleoside {source="wikipedia.en"}
is_a: CHEBI:21731 ! N-glycosyl compound
is_a: CHEBI:26912 ! oxolanes
is_a: CHEBI:61120 ! nucleobase-containing molecular entity
relationship: RO:0018038 CHEBI:16646 ! has functional parent carbohydrate
[Term]
id: CHEBI:33839
name: macromolecule
def: "A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." []
subset: 3:STAR
synonym: "macromolecule" EXACT IUPAC:NAME [IUPAC]
synonym: "macromolecule" RELATED IUPAC:NAME [iupac]
synonym: "macromolecules" RELATED [chebi]
synonym: "polymer" RELATED [chebi]
synonym: "polymer molecule" RELATED [iupac]
synonym: "polymers" RELATED [chebi]
xref: wikipedia.en:Macromolecule {source="wikipedia.en"}
is_a: CHEBI:36357 ! polyatomic entity
[Term]
id: CHEBI:33842
name: aromatic annulene
subset: 3:STAR
synonym: "aromatic annulenes" RELATED [chebi]
is_a: CHEBI:33662 ! annulene
is_a: CHEBI:33847 ! monocyclic arene
[Term]
id: CHEBI:33847
name: monocyclic arene
def: "A monocyclic aromatic hydrocarbon." []
subset: 3:STAR
synonym: "monocyclic arenes" RELATED [chebi]
is_a: CHEBI:33658 ! arene
[Term]
id: CHEBI:33853
name: phenols
alt_id: CHEBI:13664
alt_id: CHEBI:13825
alt_id: CHEBI:25969
alt_id: CHEBI:2857
alt_id: CHEBI:29322
def: "Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring." []
subset: 3:STAR
synonym: "a phenol" RELATED [uniprot_ft]
synonym: "arenols" RELATED [iupac]
synonym: "Aryl alcohol" RELATED [kegg.compound]
synonym: "phenols" EXACT IUPAC:NAME [IUPAC]
synonym: "phenols" RELATED IUPAC:NAME [iupac]
xref: kegg.compound:C15584 {source="kegg.compound"}
xref: metacyc.compound:Phenols {source="metacyc.compound"}
xref: wikipedia.en:Phenols {source="wikipedia.en"}
is_a: CHEBI:33659 ! organic aromatic compound
is_a: CHEBI:33822 ! organic hydroxy compound
[Term]
id: CHEBI:33856
name: aromatic amino acid
alt_id: CHEBI:13820
alt_id: CHEBI:22623
alt_id: CHEBI:2835
def: "An amino acid whose structure includes an aromatic ring." []
subset: 3:STAR
synonym: "Aromatic amino acid" RELATED [kegg.compound]
synonym: "aromatic amino acids" RELATED [chebi]
xref: kegg.compound:C01021 {source="kegg.compound"}
xref: wikipedia.en:Aromatic_amino_acid {source="wikipedia.en"}
is_a: CHEBI:33659 ! organic aromatic compound
is_a: CHEBI:33709 ! amino acid
relationship: RO:0018034 CHEBI:63473 ! is protonated form of aromatic amino-acid anion
relationship: RO:0018036 CHEBI:76042 ! is tautomer of aromatic amino-acid zwitterion
[Term]
id: CHEBI:33893
name: reagent
def: "A substance used in a chemical reaction to detect, measure, examine, or produce other substances." []
subset: 3:STAR
synonym: "reactif" RELATED [iupac]
synonym: "reactivo" RELATED [iupac]
synonym: "reagent" EXACT IUPAC:NAME [IUPAC]
synonym: "reagent" RELATED IUPAC:NAME [iupac]
synonym: "reagents" RELATED [chebi]
is_a: CHEBI:33232 ! application
[Term]
id: CHEBI:33916
name: aldopentose
def: "A pentose with a (potential) aldehyde group at one end." []
subset: 3:STAR
synonym: "aldopentose" RELATED [chebi]
synonym: "aldopentoses" RELATED [chebi]
xref: pubmed:10723607 {source="pubmed"}
is_a: CHEBI:15693 ! aldose
is_a: CHEBI:25901 ! pentose
[Term]
id: CHEBI:33917
name: aldohexose
alt_id: CHEBI:2558
def: "A hexose with a (potential) aldehyde group at one end." []
subset: 3:STAR
synonym: "aldohexose" RELATED [chebi]
synonym: "aldohexoses" RELATED [chebi]
is_a: CHEBI:15693 ! aldose
is_a: CHEBI:18133 ! hexose
[Term]
id: CHEBI:33937
name: macronutrient
def: "Any nutrient required in large quantities by organisms throughout their life in order to orchestrate a range of physiological functions. Macronutrients are usually chemical elements (carbon, hydrogen, nitrogen, oxygen, phosphorus and sulfur) that humans consume in the largest quantities. Calcium, sodium, magnesium and potassium are sometimes included as macronutrients because they are required in relatively large quantities compared with other vitamins and minerals." []
subset: 3:STAR
synonym: "macronutrients" RELATED [chebi]
is_a: CHEBI:33284 ! nutrient
[Term]
id: CHEBI:33942
name: ribose
alt_id: CHEBI:26564
def: "Any aldopentose where the open-chain form has all the hydroxy groups on the same side in the Fischer projection. Occurrs in two enantiomeric forms, D- and L-ribose, of which only the former is found in nature." []
subset: 3:STAR
synonym: "Rib" RELATED [jcbn]
synonym: "ribo-pentose" EXACT IUPAC:NAME [IUPAC]
synonym: "ribo-pentose" RELATED IUPAC:NAME [iupac]
synonym: "ribose" EXACT IUPAC:NAME [IUPAC]
synonym: "ribose" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:33916 ! aldopentose
[Term]
id: CHEBI:350546
name: serotonin(1+)
def: "An ammonium ion that is the conjugate acid of serotonin; major species at pH 7.3." []
subset: 3:STAR
synonym: "2-(5-hydroxy-1H-indol-3-yl)ethanaminium" EXACT IUPAC:NAME [IUPAC]
synonym: "2-(5-hydroxy-1H-indol-3-yl)ethanaminium" RELATED IUPAC:NAME [iupac]
synonym: "serotonin" RELATED [uniprot_ft]
synonym: "serotonin cation" RELATED [chebi]
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018034 CHEBI:28790 ! is protonated form of serotonin
[Term]
id: CHEBI:35106
name: nitrogen hydride
subset: 3:STAR
synonym: "nitrogen hydrides" RELATED [chebi]
is_a: CHEBI:35881 ! pnictogen hydride
is_a: CHEBI:51143 ! nitrogen molecular entity
[Term]
id: CHEBI:35107
name: azane
def: "Saturated acyclic nitrogen hydrides having the general formula NnHn+2." []
subset: 3:STAR
synonym: "azanes" RELATED [chebi]
is_a: CHEBI:35106 ! nitrogen hydride
[Term]
id: CHEBI:35131
name: aldose phosphate
subset: 3:STAR
synonym: "aldose phosphates" RELATED [chebi]
is_a: CHEBI:33447 ! phospho sugar
[Term]
id: CHEBI:35147
name: (6'R)-beta,epsilon-carotene
subset: 3:STAR
synonym: "(+)-alpha-carotene" RELATED [chemidplus]
synonym: "(6'R)-beta,epsilon-carotene" EXACT IUPAC:NAME [IUPAC]
synonym: "(6'R)-beta,epsilon-carotene" RELATED IUPAC:NAME [iupac]
synonym: "alpha-carotene (natural)" RELATED [chemidplus]
xref: beilstein:2067409 {source="beilstein"}
xref: cas:7488-99-5 {source="cas"}
xref: lipidmaps:LMPR01070011 {source="lipidmaps"}
is_a: CHEBI:28425 ! alpha-carotene
relationship: RO:0018039 CHEBI:35148 ! is enantiomer of (6'S)-beta,epsilon-carotene
[Term]
id: CHEBI:35148
name: (6'S)-beta,epsilon-carotene
subset: 3:STAR
synonym: "(6'S)-beta,epsilon-carotene" EXACT IUPAC:NAME [IUPAC]
synonym: "(6'S)-beta,epsilon-carotene" RELATED IUPAC:NAME [iupac]
xref: beilstein:2682045 {source="beilstein"}
is_a: CHEBI:28425 ! alpha-carotene
relationship: RO:0018039 CHEBI:35147 ! is enantiomer of (6'R)-beta,epsilon-carotene
[Term]
id: CHEBI:35155
name: elemental calcium
subset: 3:STAR
is_a: CHEBI:22985 ! calcium molecular entity
[Term]
id: CHEBI:35156
name: calcium salt
subset: 3:STAR
synonym: "calcium salts" RELATED [chebi]
synonym: "Kalziumsalz" RELATED [chebi]
synonym: "Kalziumsalze" RELATED [chebi]
is_a: CHEBI:22985 ! calcium molecular entity
is_a: CHEBI:36364 ! alkaline earth salt
relationship: has_part CHEBI:29108 ! calcium(2+)
[Term]
id: CHEBI:35163
name: cyclic carotene
subset: 3:STAR
synonym: "cyclic carotene" RELATED [chebi]
synonym: "cyclic carotenes" RELATED [chebi]
is_a: CHEBI:23042 ! carotene
[Term]
id: CHEBI:35186
name: terpene
def: "A hydrocarbon of biological origin having carbon skeleton formally derived from isoprene [CH2=C(CH3)CH=CH2]." []
subset: 3:STAR
synonym: "Terpen" RELATED [chebi]
synonym: "terpene" RELATED [iupac]
synonym: "terpenes" EXACT IUPAC:NAME [IUPAC]
synonym: "terpenes" RELATED IUPAC:NAME [iupac]
synonym: "terpeno" RELATED [iupac]
synonym: "terpenos" RELATED [iupac]
is_a: CHEBI:24632 ! hydrocarbon
is_a: CHEBI:24913 ! isoprenoid
[Term]
id: CHEBI:35189
name: sesquiterpene
def: "A C15 terpene." []
subset: 3:STAR
synonym: "Sesquiterpen" RELATED [chebi]
synonym: "sesquiterpenes" EXACT IUPAC:NAME [IUPAC]
synonym: "sesquiterpenes" RELATED IUPAC:NAME [iupac]
synonym: "sesquiterpeno" RELATED [iupac]
synonym: "sesquiterpenos" RELATED [iupac]
is_a: CHEBI:35186 ! terpene
[Term]
id: CHEBI:35191
name: triterpene
def: "A C30 terpene." []
subset: 3:STAR
synonym: "Triterpen" RELATED [chebi]
synonym: "triterpenes" EXACT IUPAC:NAME [IUPAC]
synonym: "triterpenes" RELATED IUPAC:NAME [iupac]
synonym: "triterpeno" RELATED [iupac]
synonym: "triterpenos" RELATED [iupac]
is_a: CHEBI:35186 ! terpene
[Term]
id: CHEBI:35193
name: tetraterpene
def: "A C40 terpene." []
subset: 3:STAR
synonym: "tetraterpenes" EXACT IUPAC:NAME [IUPAC]
synonym: "tetraterpenes" RELATED IUPAC:NAME [iupac]
synonym: "tetraterpeno" RELATED [iupac]
synonym: "tetraterpenos" RELATED [iupac]
is_a: CHEBI:35186 ! terpene
[Term]
id: CHEBI:35222
name: inhibitor
def: "A substance that diminishes the rate of a chemical reaction." []
subset: 3:STAR
synonym: "inhibidor" RELATED [chebi]
synonym: "inhibiteur" RELATED [chebi]
synonym: "inhibitor" EXACT IUPAC:NAME [IUPAC]
synonym: "inhibitor" RELATED IUPAC:NAME [iupac]
synonym: "inhibitors" RELATED [chebi]
is_a: CHEBI:24432 ! biological role
[Term]
id: CHEBI:35223
name: catalyst
def: "A substance that increases the rate of a reaction without modifying the overall standard Gibbs energy change in the reaction." []
subset: 3:STAR
synonym: "catalizador" RELATED [chebi]
synonym: "catalyseur" RELATED [chebi]
synonym: "catalyst" EXACT IUPAC:NAME [IUPAC]
synonym: "catalyst" RELATED IUPAC:NAME [iupac]
synonym: "Katalysator" RELATED [chebi]
is_a: CHEBI:51086 ! chemical role
[Term]
id: CHEBI:35238
name: amino-acid zwitterion
def: "The zwitterionic form of an amino acid having a negatively charged carboxyl group and a positively charged amino group." []
subset: 3:STAR
synonym: "amino acid zwitterion" RELATED [chebi]
synonym: "amino acid zwitterions" RELATED [chebi]
synonym: "amino-acid zwitterions" RELATED [chebi]
is_a: CHEBI:27369 ! zwitterion
[Term]
id: CHEBI:35267
name: quaternary ammonium ion
alt_id: CHEBI:26470
alt_id: CHEBI:8693
def: "A derivative of ammonium, NH4+, in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups." []
subset: 3:STAR
synonym: "a quaternary ammonium" RELATED [uniprot_ft]
synonym: "Quaternary amine" RELATED [kegg.compound]
synonym: "quaternary ammonium ion" EXACT IUPAC:NAME [IUPAC]
synonym: "quaternary ammonium ion" RELATED IUPAC:NAME [iupac]
synonym: "quaternary ammonium ions" RELATED [chebi]
xref: kegg.compound:C06703 {source="kegg.compound"}
is_a: CHEBI:25697 ! organic cation
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: RO:0018040 CHEBI:28938 ! has parent hydride ammonium
[Term]
id: CHEBI:35274
name: ammonium ion derivative
def: "A derivative of ammonium, NH4+, in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc)." []
subset: 3:STAR
synonym: "ammonium ion derivatives" RELATED [chebi]
synonym: "azanium ion derivative" RELATED [chebi]
synonym: "azanium ion derivatives" RELATED [chebi]
is_a: CHEBI:33702 ! polyatomic cation
is_a: CHEBI:51143 ! nitrogen molecular entity
relationship: RO:0018040 CHEBI:28938 ! has parent hydride ammonium
[Term]
id: CHEBI:35281
name: onium betaine
def: "Neutral molecules having charge-separated forms with an onium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom." []
subset: 3:STAR
synonym: "betaines" EXACT IUPAC:NAME [IUPAC]
synonym: "betaines" RELATED IUPAC:NAME [iupac]
synonym: "onium betaines" RELATED [chebi]
is_a: CHEBI:27369 ! zwitterion
[Term]
id: CHEBI:35284
name: ammonium betaine
def: "Any neutral molecule having charge-separated forms with a quaternary ammonium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom." []
subset: 3:STAR
synonym: "ammonium betaines" RELATED [chebi]
is_a: CHEBI:26469 ! quaternary nitrogen compound
is_a: CHEBI:35281 ! onium betaine
[Term]
id: CHEBI:35287
name: acylcholine
alt_id: CHEBI:13245
alt_id: CHEBI:22227
alt_id: CHEBI:2463
def: "A choline ester formed from choline and a carboxylic acid." []
subset: 3:STAR
synonym: "acylcholines" RELATED [chebi]
synonym: "an acylcholine" RELATED [uniprot_ft]
xref: kegg.compound:C01777 {source="kegg.compound"}
is_a: CHEBI:35267 ! quaternary ammonium ion
[Term]
id: CHEBI:35341
name: steroid
alt_id: CHEBI:13687
alt_id: CHEBI:26768
alt_id: CHEBI:9263
def: "Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene which is a triterpene." []
subset: 3:STAR
synonym: "a steroid" RELATED [uniprot_ft]
synonym: "Steroid" RELATED [kegg.compound]
synonym: "steroids" EXACT IUPAC:NAME [IUPAC]
synonym: "steroids" RELATED IUPAC:NAME [iupac]
xref: kegg.compound:C00377 {source="kegg.compound"}
xref: metacyc.compound:Steroids {source="metacyc.compound"}
is_a: CHEBI:18059 ! lipid
is_a: CHEBI:51958 ! organic polycyclic compound
[Term]
id: CHEBI:35343
name: 17beta-hydroxy steroid
alt_id: CHEBI:19176
alt_id: CHEBI:794
def: "A 17-hydroxy steroid in which the hydroxy group at position 17 has a β-configuration." []
subset: 3:STAR
synonym: "17beta-hydroxy steroids" RELATED [chebi]
synonym: "17beta-hydroxysteroid" RELATED [kegg.compound]
synonym: "17beta-hydroxysteroids" RELATED [chebi]
synonym: "a 17-beta-hydroxy steroid" RELATED [uniprot_ft]
xref: kegg.compound:C03051 {source="kegg.compound"}
xref: metacyc.compound:17-beta-Hydroxysteroids {source="metacyc.compound"}
is_a: CHEBI:36838 ! 17-hydroxy steroid
[Term]
id: CHEBI:35344
name: 21-hydroxy steroid
alt_id: CHEBI:1300
alt_id: CHEBI:13596
alt_id: CHEBI:19803
subset: 3:STAR
synonym: "21-hydroxy steroids" RELATED [chebi]
synonym: "21-Hydroxysteroid" RELATED [kegg.compound]
synonym: "21-hydroxysteroids" RELATED [chebi]
xref: kegg.compound:C02506 {source="kegg.compound"}
is_a: CHEBI:35350 ! hydroxy steroid
[Term]
id: CHEBI:35346
name: 11beta-hydroxy steroid
alt_id: CHEBI:13774
alt_id: CHEBI:19134
alt_id: CHEBI:738
def: "Any 11-hydroxy steroid in which the hydroxy group at position 11 has β- configuration." []
subset: 3:STAR
synonym: "11beta-hydroxy steroids" RELATED [chebi]
synonym: "11beta-Hydroxysteroid" RELATED [kegg.compound]
synonym: "11beta-hydroxysteroids" RELATED [chebi]
synonym: "an 11-beta-hydroxysteroid" RELATED [uniprot_ft]
xref: kegg.compound:C01058 {source="kegg.compound"}
is_a: CHEBI:36841 ! 11-hydroxy steroid
[Term]
id: CHEBI:35350
name: hydroxy steroid
alt_id: CHEBI:24748
alt_id: CHEBI:5814
subset: 3:STAR
synonym: "hydroxy steroids" RELATED [chebi]
synonym: "Hydroxysteroid" RELATED [kegg.compound]
synonym: "hydroxysteroids" RELATED [chebi]
xref: kegg.compound:C02159 {source="kegg.compound"}
is_a: CHEBI:33822 ! organic hydroxy compound
is_a: CHEBI:35341 ! steroid
[Term]
id: CHEBI:35352
name: organonitrogen compound
def: "Any heteroorganic entity containing at least one carbon-nitrogen bond." []
subset: 3:STAR
synonym: "organonitrogen compounds" EXACT IUPAC:NAME [IUPAC]
synonym: "organonitrogen compounds" RELATED IUPAC:NAME [iupac]
synonym: "organonitrogens" RELATED [chebi]
is_a: CHEBI:33285 ! heteroorganic entity
is_a: CHEBI:51143 ! nitrogen molecular entity
[Term]
id: CHEBI:35366
name: fatty acid
alt_id: CHEBI:13633
alt_id: CHEBI:24024
alt_id: CHEBI:4984
def: "Any aliphatic monocarboxylic acid derived from or contained in esterified form in an animal or vegetable fat, oil or wax. Natural fatty acids commonly have a chain of 4 to 28 carbons (usually unbranched and even-numbered), which may be saturated or unsaturated. By extension, the term is sometimes used to embrace all acyclic aliphatic carboxylic acids." []
subset: 3:STAR
synonym: "acide gras" RELATED [chebi]
synonym: "acides gras" RELATED [chemidplus]
synonym: "acido graso" RELATED [chebi]
synonym: "acidos grasos" RELATED [chebi]
synonym: "Fatty acid" RELATED [kegg.compound]
synonym: "fatty acids" EXACT IUPAC:NAME [IUPAC]
synonym: "fatty acids" RELATED IUPAC:NAME [chebi, iupac]
synonym: "Fettsaeure" RELATED [chebi]
synonym: "Fettsaeuren" RELATED [chebi]
xref: kegg.compound:C00162 {source="kegg.compound"}
xref: pubmed:14287444 {source="pubmed"}
xref: pubmed:14300208 {source="pubmed"}
xref: pubmed:14328676 {source="pubmed"}
xref: wikipedia.en:Fatty_acid {source="wikipedia.en"}
is_a: CHEBI:18059 ! lipid
is_a: CHEBI:25384 ! monocarboxylic acid
relationship: RO:0018034 CHEBI:28868 ! is protonated form of fatty acid anion
[Term]
id: CHEBI:35381
name: monosaccharide
alt_id: CHEBI:25407
alt_id: CHEBI:6984
def: "Parent monosaccharides are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H‒[CHOH]n‒C(=O)[CHOH]m‒H with three or more carbon atoms. The generic term 'monosaccharide' (as opposed to oligosaccharide or polysaccharide) denotes a single unit, without glycosidic connection to other such units. It includes aldoses, dialdoses, aldoketoses, ketoses and diketoses, as well as deoxy sugars, provided that the parent compound has a (potential) carbonyl group." []
subset: 3:STAR
synonym: "monosacarido" RELATED [chebi]
synonym: "monosacaridos" RELATED [iupac]
synonym: "Monosaccharid" RELATED [chebi]
synonym: "Monosaccharide" RELATED [kegg.compound]
synonym: "monosaccharides" EXACT IUPAC:NAME [IUPAC]
synonym: "monosaccharides" RELATED IUPAC:NAME [iupac]
synonym: "Monosacharid" RELATED [chebi]
xref: kegg.compound:C06698 {source="kegg.compound"}
is_a: CHEBI:16646 ! carbohydrate
[Term]
id: CHEBI:35406
name: oxoanion
alt_id: CHEBI:33274
alt_id: CHEBI:33436
def: "An oxoanion is an anion derived from an oxoacid by loss of hydron(s) bound to oxygen." []
subset: 3:STAR
synonym: "oxoacid anions" RELATED [chebi]
synonym: "oxoanion" RELATED [chebi]
synonym: "oxoanions" RELATED [chebi]
is_a: CHEBI:25741 ! oxide
is_a: CHEBI:33273 ! polyatomic anion
[Term]
id: CHEBI:35416
name: alpha-amino-acid residue anion
subset: 3:STAR
synonym: "alpha-amino-acid residue anions" RELATED [chebi]
is_a: CHEBI:64898 ! anionic amino-acid residue
[Term]
id: CHEBI:35441
name: antiinfective agent
def: "A substance used in the prophylaxis or therapy of infectious diseases." []
subset: 3:STAR
synonym: "anti-infective agents" RELATED [chebi]
synonym: "anti-infective drugs" RELATED [chebi]
synonym: "antiinfective agents" RELATED [chebi]
synonym: "antiinfective drug" RELATED [chebi]
is_a: CHEBI:23888 ! drug
[Term]
id: CHEBI:35470
name: central nervous system drug
def: "A class of drugs producing both physiological and psychological effects through a variety of mechanisms involving the central nervous system." []
subset: 3:STAR
synonym: "central nervous system agents" RELATED [chebi]
synonym: "CNS agent" RELATED [chebi]
synonym: "CNS drugs" RELATED [chebi]
is_a: CHEBI:23888 ! drug
[Term]
id: CHEBI:35472
name: anti-inflammatory drug
def: "A substance that reduces or suppresses inflammation." []
subset: 3:STAR
synonym: "anti-inflammatory drugs" RELATED [chebi]
synonym: "antiinflammatory agent" RELATED [chebi]
synonym: "antiinflammatory drug" RELATED [chebi]
synonym: "antiinflammatory drugs" RELATED [chebi]
is_a: CHEBI:23888 ! drug
is_a: CHEBI:67079 ! anti-inflammatory agent
[Term]
id: CHEBI:35479
name: alkali metal salt
subset: 3:STAR
synonym: "alkali metal salts" RELATED [chebi]
is_a: CHEBI:24866 ! salt
is_a: CHEBI:33296 ! alkali metal molecular entity
[Term]
id: CHEBI:35480
name: analgesic
def: "An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms." []
subset: 3:STAR
is_a: CHEBI:23888 ! drug
is_a: CHEBI:52210 ! pharmacological role
[Term]
id: CHEBI:35488
name: central nervous system depressant
def: "A loosely defined group of drugs that tend to reduce the activity of the central nervous system." []
subset: 3:STAR
synonym: "central nervous system depressants" RELATED [chebi]
synonym: "CNS depressants" RELATED [chebi]
is_a: CHEBI:35470 ! central nervous system drug
[Term]
id: CHEBI:35507
name: natural product fundamental parent
subset: 3:STAR
synonym: "natural product fundamental parents" EXACT IUPAC:NAME [IUPAC]
synonym: "natural product fundamental parents" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:33245 ! organic fundamental parent
[Term]
id: CHEBI:35508
name: steroid fundamental parent
subset: 3:STAR
synonym: "steroid fundamental parents" RELATED [chebi]
is_a: CHEBI:35341 ! steroid
is_a: CHEBI:35507 ! natural product fundamental parent
[Term]
id: CHEBI:35509
name: androstane
subset: 3:STAR
synonym: "androstane" EXACT IUPAC:NAME [IUPAC]
synonym: "androstane" RELATED IUPAC:NAME [iupac]
xref: beilstein:5247532 {source="beilstein"}
xref: cas:24887-75-0 {source="cas"}
xref: lipidmaps:LMST02020000 {source="lipidmaps"}
is_a: CHEBI:35508 ! steroid fundamental parent
[Term]
id: CHEBI:35519
name: cholane
subset: 3:STAR
synonym: "cholane" EXACT IUPAC:NAME [IUPAC]
synonym: "cholane" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:35508 ! steroid fundamental parent
[Term]
id: CHEBI:35522
name: beta-adrenergic agonist
def: "An agent that selectively binds to and activates β-adrenergic receptors." []
subset: 3:STAR
synonym: "beta-adrenergic agonists" RELATED [chebi]
synonym: "beta-adrenergic receptor agonist" RELATED [chebi]
synonym: "beta-adrenoceptor agonists" RELATED [iuphar]
is_a: CHEBI:37886 ! adrenergic agonist
is_a: CHEBI:48540 ! beta-adrenergic drug
[Term]
id: CHEBI:35523
name: bronchodilator agent
def: "An agent that causes an increase in the expansion of a bronchus or bronchial tubes." []
subset: 3:STAR
synonym: "bronchodilator" RELATED [chebi]
synonym: "bronchodilator agents" RELATED [chebi]
synonym: "broncholytic agent" RELATED [chebi]
is_a: CHEBI:23888 ! drug
[Term]
id: CHEBI:35524
name: sympathomimetic agent
def: "A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters." []
subset: 3:STAR
synonym: "sympathomimetic" RELATED [chebi]
synonym: "sympathomimetics" RELATED [chebi]
is_a: CHEBI:37962 ! adrenergic agent
[Term]
id: CHEBI:35552
name: heterocyclic organic fundamental parent
subset: 3:STAR
synonym: "heterocyclic fundamental parent" RELATED [chebi]
synonym: "heterocyclic organic fundamental parents" RELATED [chebi]
synonym: "heterocyclic parent hydrides" EXACT IUPAC:NAME [IUPAC]
synonym: "heterocyclic parent hydrides" RELATED IUPAC:NAME [iupac]
synonym: "organic heterocyclic fundamental parents" RELATED [chebi]
is_a: CHEBI:33245 ! organic fundamental parent
[Term]
id: CHEBI:35554
name: cardiovascular drug
def: "A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume." []
subset: 3:STAR
synonym: "cardiovascular agent" RELATED [chebi]
synonym: "cardiovascular drugs" RELATED [chebi]
is_a: CHEBI:23888 ! drug
[Term]
id: CHEBI:35568
name: mancude ring
def: "Any molecular entity that consists of a ring having (formally) the maximum number of noncumulative double bonds." []
subset: 3:STAR
synonym: "mancude rings" RELATED [chebi]
synonym: "mancude-ring systems" EXACT IUPAC:NAME [IUPAC]
synonym: "mancude-ring systems" RELATED IUPAC:NAME [iupac]
synonym: "mancunide-ring systems" RELATED [iupac]
is_a: CHEBI:23367 ! molecular entity
[Term]
id: CHEBI:35569
name: alpha-adrenergic agonist
def: "An agent that selectively binds to and activates α-adrenergic receptors." []
subset: 3:STAR
synonym: "alpha-adrenergic agonists" RELATED [chebi]
synonym: "alpha-adrenergic receptor agonist" RELATED [chebi]
synonym: "alpha-adrenoceptor agonists" RELATED [iuphar]
is_a: CHEBI:37886 ! adrenergic agonist
is_a: CHEBI:48539 ! alpha-adrenergic drug
[Term]
id: CHEBI:35570
name: mancude organic heterobicyclic parent
subset: 3:STAR
synonym: "mancude organic heterobicyclic parents" RELATED [chebi]
synonym: "mancude-ring organic heterobicyclic parents" RELATED [chebi]
is_a: CHEBI:27171 ! organic heterobicyclic compound
is_a: CHEBI:35571 ! mancude organic heterocyclic parent
[Term]
id: CHEBI:35571
name: mancude organic heterocyclic parent
subset: 3:STAR
synonym: "mancude organic heterocyclic parents" RELATED [chebi]
synonym: "mancude-ring organic heterocyclic parents" RELATED [chebi]
is_a: CHEBI:35552 ! heterocyclic organic fundamental parent
is_a: CHEBI:35573 ! organic mancude parent
[Term]
id: CHEBI:35573
name: organic mancude parent
subset: 3:STAR
synonym: "organic mancude parents" RELATED [chebi]
synonym: "organic mancude-ring parents" RELATED [chebi]
is_a: CHEBI:33245 ! organic fundamental parent
is_a: CHEBI:35568 ! mancude ring
[Term]
id: CHEBI:35584
name: purine
def: "A heterobicyclic aromatic organic compound comprising a pyrimidine ring fused to an imidazole ring; the parent compound of the purines." []
subset: 3:STAR
synonym: "purine" EXACT IUPAC:NAME [IUPAC]
synonym: "purine" RELATED IUPAC:NAME [iupac]
xref: hmdb:HMDB0001366 {source="hmdb"}
xref: kegg.compound:C15587 {source="kegg.compound"}
xref: metacyc.compound:PURINE {source="metacyc.compound"}
xref: pubmed:12865945 {source="pubmed"}
xref: pubmed:24088627 {source="pubmed"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:26401 ! purines
is_a: CHEBI:35570 ! mancude organic heterobicyclic parent
relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
[Term]
id: CHEBI:35586
name: 1H-purine
def: "The 1H-tautomer of purine." []
subset: 3:STAR
synonym: "1H-purine" RELATED [chebi]
xref: gmelin:2379911 {source="gmelin"}
is_a: CHEBI:35584 ! purine
relationship: RO:0018036 CHEBI:17258 ! is tautomer of 7H-purine
relationship: RO:0018036 CHEBI:35588 ! is tautomer of 3H-purine
relationship: RO:0018036 CHEBI:35589 ! is tautomer of 9H-purine
[Term]
id: CHEBI:35588
name: 3H-purine
def: "The 3H-tautomer of purine." []
subset: 3:STAR
synonym: "3H-purine" EXACT IUPAC:NAME [IUPAC]
synonym: "3H-purine" RELATED IUPAC:NAME [iupac]
xref: pubmed:6149478 {source="pubmed"}
xref: pubmed:7178185 {source="pubmed"}
xref: pubmed:7296170 {source="pubmed"}
xref: reaxys:1210196 {source="reaxys"}
is_a: CHEBI:35584 ! purine
relationship: RO:0018036 CHEBI:17258 ! is tautomer of 7H-purine
relationship: RO:0018036 CHEBI:35586 ! is tautomer of 1H-purine
relationship: RO:0018036 CHEBI:35589 ! is tautomer of 9H-purine
[Term]
id: CHEBI:35589
name: 9H-purine
def: "The 9H-tautomer of purine." []
subset: 3:STAR
synonym: "9H-purine" EXACT IUPAC:NAME [IUPAC]
synonym: "9H-purine" RELATED IUPAC:NAME [iupac, uniprot_ft]
xref: beilstein:606899 {source="beilstein"}
xref: cas:120-73-0 {source="cas"}
xref: gmelin:3120 {source="gmelin"}
xref: wikipedia.en:Purine {source="wikipedia.en"}
is_a: CHEBI:35584 ! purine
relationship: RO:0018036 CHEBI:17258 ! is tautomer of 7H-purine
relationship: RO:0018036 CHEBI:35586 ! is tautomer of 1H-purine
relationship: RO:0018036 CHEBI:35588 ! is tautomer of 3H-purine
[Term]
id: CHEBI:35604
name: carbon oxoanion
def: "A negative ion consisting solely of carbon and oxygen atoms, and therefore having the general formula CxOyn− for some integers x, y and n." []
subset: 3:STAR
synonym: "carbon oxoanion" RELATED [chebi]
synonym: "carbon oxoanions" RELATED [chebi]
synonym: "oxocarbon anion" RELATED [chebi]
synonym: "oxocarbon anions" RELATED [chebi]
is_a: CHEBI:25696 ! organic anion
is_a: CHEBI:35406 ! oxoanion
is_a: CHEBI:36963 ! organooxygen compound
[Term]
id: CHEBI:35605
name: carbon oxoacid
subset: 3:STAR
synonym: "carbon oxoacids" RELATED [chebi]
synonym: "oxoacids of carbon" RELATED [chebi]
is_a: CHEBI:24833 ! oxoacid
is_a: CHEBI:36963 ! organooxygen compound
[Term]
id: CHEBI:35620
name: vasodilator agent
def: "A drug used to cause dilation of the blood vessels." []
subset: 3:STAR
synonym: "vasodilator" RELATED [chebi]
synonym: "vasodilator agents" RELATED [chebi]
is_a: CHEBI:35554 ! cardiovascular drug
[Term]
id: CHEBI:35623
name: anticonvulsant
def: "A drug used to prevent seizures or reduce their severity." []
subset: 3:STAR
synonym: "anti-convulsant" RELATED [chebi]
synonym: "anti-convulsants" RELATED [chebi]
synonym: "anti-convulsive agent" RELATED [chebi]
synonym: "anti-convulsive agents" RELATED [chebi]
synonym: "anticonvulsants" RELATED [chebi]
synonym: "anticonvulsive agent" RELATED [chebi]
synonym: "anticonvulsive agents" RELATED [chebi]
synonym: "antiepileptic" RELATED [chebi]
synonym: "antiepileptics" RELATED [chebi]
synonym: "Antiepileptika" RELATED [chebi]
synonym: "Antiepileptikum" RELATED [chebi]
synonym: "antiepileptique" RELATED [chebi]
synonym: "antiepileptiques" RELATED [chebi]
synonym: "Antikonvulsiva" RELATED [chebi]
synonym: "Antikonvulsivum" RELATED [chebi]
is_a: CHEBI:35488 ! central nervous system depressant
[Term]
id: CHEBI:35692
name: dicarboxylic acid
alt_id: CHEBI:23692
alt_id: CHEBI:36172
alt_id: CHEBI:4501
def: "Any carboxylic acid containing two carboxy groups." []
subset: 3:STAR
synonym: "Dicarboxylic acid" RELATED [kegg.compound]
synonym: "dicarboxylic acids" RELATED [chebi]
xref: kegg.compound:C02028 {source="kegg.compound"}
is_a: CHEBI:131927 ! dicarboxylic acids and O-substituted derivatives
is_a: CHEBI:33575 ! carboxylic acid
relationship: RO:0018034 CHEBI:35693 ! is protonated form of dicarboxylic acid anion
[Term]
id: CHEBI:35693
name: dicarboxylic acid anion
subset: 3:STAR
synonym: "dicarboxylic acid anion" RELATED [chebi]
synonym: "dicarboxylic acid anions" RELATED [chebi]
is_a: CHEBI:29067 ! carboxylic acid anion
relationship: RO:0018033 CHEBI:35692 ! is deprotonated form of dicarboxylic acid
[Term]
id: CHEBI:35701
name: ester
alt_id: CHEBI:23960
alt_id: CHEBI:4859
def: "A compound formally derived from an oxoacid RkE(=O)l(OH)m (l > 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter." []
subset: 3:STAR
synonym: "Ester" RELATED [kegg.compound]
synonym: "esters" RELATED [chebi]
xref: kegg.compound:C00287 {source="kegg.compound"}
xref: wikipedia.en:Ester {source="wikipedia.en"}
is_a: CHEBI:36963 ! organooxygen compound
[Term]
id: CHEBI:35718
name: antifungal agent
def: "An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce." []
subset: 3:STAR
synonym: "antifungal" RELATED [chebi]
synonym: "antifungal agents" RELATED [chebi]
synonym: "antifungal drug" RELATED [chebi]
synonym: "antifungal drugs" RELATED [chebi]
synonym: "antifungals" RELATED [chebi]
is_a: CHEBI:33281 ! antimicrobial agent
[Term]
id: CHEBI:35722
name: sulfated glycosaminoglycan
subset: 3:STAR
synonym: "glycosaminoglycan sulfate" RELATED [chebi]
synonym: "glycosaminoglycan sulfates" RELATED [chebi]
synonym: "sulfated glycosaminoglycans" RELATED [chebi]
is_a: CHEBI:18085 ! glycosaminoglycan
is_a: CHEBI:35724 ! carbohydrate sulfate
[Term]
id: CHEBI:35724
name: carbohydrate sulfate
subset: 3:STAR
synonym: "carbohydrate sulfates" RELATED [chebi]
synonym: "carbohydrate sulphates" RELATED [chebi]
is_a: CHEBI:25704 ! organic sulfate
is_a: CHEBI:26819 ! sulfuric ester
is_a: CHEBI:63299 ! carbohydrate derivative
[Term]
id: CHEBI:35740
name: liposaccharide
subset: 3:STAR
synonym: "liposaccharides" RELATED [chebi]
is_a: CHEBI:18059 ! lipid
is_a: CHEBI:63299 ! carbohydrate derivative
[Term]
id: CHEBI:35757
name: monocarboxylic acid anion
alt_id: CHEBI:13657
alt_id: CHEBI:25382
alt_id: CHEBI:3407
def: "A carboxylic acid anion formed when the carboxy group of a monocarboxylic acid is deprotonated." []
subset: 3:STAR
synonym: "a monocarboxylate" RELATED [uniprot_ft]
synonym: "Carboxylate" RELATED [kegg.compound]
synonym: "Monocarboxylate" RELATED [kegg.compound]
synonym: "monocarboxylates" RELATED [chebi]
synonym: "monocarboxylic acid anions" RELATED [chebi]
xref: kegg.compound:C00060 {source="kegg.compound"}
is_a: CHEBI:29067 ! carboxylic acid anion
relationship: RO:0018033 CHEBI:25384 ! is deprotonated form of monocarboxylic acid
[Term]
id: CHEBI:35780
name: phosphate ion
def: "A phosphorus oxoanion that is the conjugate base of phosphoric acid." []
subset: 3:STAR
synonym: "phosphate" RELATED [chebi]
synonym: "phosphate ions" RELATED [chebi]
synonym: "Pi" RELATED [chebi]
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:33461 ! phosphorus oxoanion
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018033 CHEBI:26078 ! is deprotonated form of phosphoric acid
[Term]
id: CHEBI:35786
name: phosphosphingolipid
subset: 3:STAR
synonym: "phosphosphingolipids" RELATED [chebi]
synonym: "sphingophospholipid" RELATED [chebi]
synonym: "sphingophospholipids" RELATED [chebi]
is_a: CHEBI:16247 ! phospholipid
is_a: CHEBI:26739 ! sphingolipid
[Term]
id: CHEBI:35789
name: oxo steroid
alt_id: CHEBI:24979
alt_id: CHEBI:25804
subset: 3:STAR
synonym: "keto steroids" RELATED [chebi]
synonym: "ketosteroids" RELATED [chebi]
synonym: "oxo steroids" RELATED [chebi]
synonym: "oxosteroids" RELATED [chebi]
is_a: CHEBI:17087 ! ketone
is_a: CHEBI:35341 ! steroid
[Term]
id: CHEBI:35794
name: tetrapyrrole fundamental parent
subset: 3:STAR
synonym: "tetrapyrrole fundamental parents" RELATED [chebi]
is_a: CHEBI:26932 ! tetrapyrrole
is_a: CHEBI:35507 ! natural product fundamental parent
[Term]
id: CHEBI:35875
name: imidazopyrimidine
subset: 3:STAR
synonym: "imidazopyrimidines" RELATED [chebi]
is_a: CHEBI:27171 ! organic heterobicyclic compound
is_a: CHEBI:33833 ! heteroarene
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound
[Term]
id: CHEBI:35881
name: pnictogen hydride
subset: 3:STAR
synonym: "pnictogen hydride" RELATED [chebi]
synonym: "pnictogen hydrides" RELATED [chebi]
is_a: CHEBI:33242 ! inorganic hydride
is_a: CHEBI:33302 ! pnictogen molecular entity
[Term]
id: CHEBI:35903
name: oxo carboxylic acid anion
def: "Any carboxylic acid anion containing at least one oxo group." []
subset: 3:STAR
synonym: "oxo carboxylic acid anions" RELATED [chebi]
is_a: CHEBI:29067 ! carboxylic acid anion
relationship: RO:0018033 CHEBI:25754 ! is deprotonated form of oxo carboxylic acid
[Term]
id: CHEBI:35942
name: neurotransmitter agent
def: "A substance used for its pharmacological action on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function." []
subset: 3:STAR
synonym: "neurotransmitter agents" RELATED [chebi]
is_a: CHEBI:23888 ! drug
is_a: CHEBI:52210 ! pharmacological role
[Term]
id: CHEBI:36078
name: cholanoid
alt_id: CHEBI:22867
alt_id: CHEBI:50419
subset: 3:STAR
synonym: "bile acids and derivatives" RELATED [lipidmaps]
synonym: "cholanoids" RELATED [chebi]
xref: lipidmaps_class:LMST04 {source="lipidmaps_class"}
is_a: CHEBI:35341 ! steroid
relationship: RO:0018040 CHEBI:35519 ! has parent hydride cholane
[Term]
id: CHEBI:36080
name: protein
alt_id: CHEBI:13677
alt_id: CHEBI:14911
def: "A biological macromolecule minimally consisting of one polypeptide chain synthesized at the ribosome." []
subset: 3:STAR
synonym: "proteins" EXACT IUPAC:NAME [IUPAC]
synonym: "proteins" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:33695 ! information biomacromolecule
relationship: has_part CHEBI:16541 ! protein polypeptide chain
[Term]
id: CHEBI:36145
name: oxo dicarboxylic acid
def: "Any dicarboxylic acid carrying one or more oxo groups." []
subset: 3:STAR
synonym: "oxo dicarboxylic acids" RELATED [chebi]
is_a: CHEBI:25754 ! oxo carboxylic acid
is_a: CHEBI:35692 ! dicarboxylic acid
relationship: RO:0018034 CHEBI:133294 ! is protonated form of oxo dicarboxylic acid dianion
[Term]
id: CHEBI:36235
name: bile acid anion
subset: 3:STAR
synonym: "bile acid anions" RELATED [chebi]
is_a: CHEBI:35757 ! monocarboxylic acid anion
is_a: CHEBI:50160 ! steroid acid anion
[Term]
id: CHEBI:36237
name: cholanic acid
def: "A steroid acid that consists of cholane having a carboxy group in place of the methyl group at position 24." []
subset: 3:STAR
synonym: "cholan-24-oic acid" EXACT IUPAC:NAME [IUPAC]
synonym: "cholan-24-oic acid" RELATED IUPAC:NAME [iupac]
xref: cas:25312-65-6 {source="cas"}
xref: patent:JP2008069152 {source="patent"}
xref: reaxys:13246008 {source="reaxys"}
is_a: CHEBI:36278 ! cholanic acids
[Term]
id: CHEBI:36238
name: 5beta-cholanic acid
subset: 3:STAR
synonym: "(5beta)-cholan-24-oic acid" RELATED [chemidplus]
synonym: "(5beta,17beta)-gamma-methylandrostane-17-butanoic acid" RELATED [chemidplus]
synonym: "5beta-cholan-24-oic acid" EXACT IUPAC:NAME [IUPAC]
synonym: "5beta-cholan-24-oic acid" RELATED IUPAC:NAME [iupac]
synonym: "5beta-cholanic acid" RELATED [chemidplus]
synonym: "5beta-cholanoic acid" RELATED [chemidplus]
synonym: "ursocholanic acid" RELATED [chemidplus]
xref: beilstein:3214794 {source="beilstein"}
xref: cas:546-18-9 {source="cas"}
xref: lipidmaps:LMST04010441 {source="lipidmaps"}
is_a: CHEBI:36237 ! cholanic acid
is_a: CHEBI:36248 ! 5beta-cholanic acids
[Term]
id: CHEBI:36248
name: 5beta-cholanic acids
def: "Members of the class of cholanic acids based on a 5β-cholane skeleton." []
subset: 3:STAR
is_a: CHEBI:136889 ! 5beta steroid
is_a: CHEBI:36278 ! cholanic acids
relationship: RO:0018040 CHEBI:20664 ! has parent hydride 5beta-cholane
[Term]
id: CHEBI:36277
name: bile acid salt
def: "A salt of a bile acid." []
subset: 3:STAR
synonym: "bile acid salts" RELATED [chebi]
is_a: CHEBI:24868 ! organic salt
is_a: CHEBI:36078 ! cholanoid
[Term]
id: CHEBI:36278
name: cholanic acids
alt_id: CHEBI:23166
alt_id: CHEBI:23211
subset: 1:STAR
synonym: "cholan-24-oic acids" RELATED [chebi]
is_a: CHEBI:36078 ! cholanoid
is_a: CHEBI:47891 ! steroid acid
[Term]
id: CHEBI:36309
name: cyclic tetrapyrrole
subset: 3:STAR
synonym: "cyclic tetrapyrroles" RELATED [chebi]
synonym: "macrocyclic tetrapyrrole" RELATED [chebi]
synonym: "macrocyclic tetrapyrroles" EXACT IUPAC:NAME [IUPAC]
synonym: "macrocyclic tetrapyrroles" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:26932 ! tetrapyrrole
is_a: CHEBI:47882 ! cyclic polypyrrole
[Term]
id: CHEBI:36338
name: lepton
def: "Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek λεπτοσ (small, thin)." []
subset: 3:STAR
synonym: "leptons" RELATED [chebi]
is_a: CHEBI:33233 ! fundamental particle
is_a: CHEBI:36340 ! fermion
[Term]
id: CHEBI:36339
name: baryon
def: "Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek βαρυσ (heavy)." []
subset: 3:STAR
synonym: "baryons" RELATED [chebi]
is_a: CHEBI:36340 ! fermion
is_a: CHEBI:36344 ! hadron
[Term]
id: CHEBI:36340
name: fermion
def: "Particle of half-integer spin quantum number following Fermi-Dirac statistics. Fermions are named after Enrico Fermi." []
subset: 3:STAR
synonym: "fermion" EXACT IUPAC:NAME [IUPAC]
synonym: "fermion" RELATED IUPAC:NAME [iupac]
synonym: "fermions" RELATED [chebi]
is_a: CHEBI:36342 ! subatomic particle
[Term]
id: CHEBI:36341
name: boson
def: "Particle of integer spin quantum number following Bose-Einstein statistics. Bosons are named after Satyendra Nath Bose." []
subset: 3:STAR
synonym: "boson" EXACT IUPAC:NAME [IUPAC]
synonym: "boson" RELATED IUPAC:NAME [iupac]
synonym: "bosons" RELATED [chebi]
is_a: CHEBI:36342 ! subatomic particle
[Term]
id: CHEBI:36342
name: subatomic particle
def: "A particle smaller than an atom." []
subset: 3:STAR
synonym: "subatomic particles" RELATED [chebi]
xref: wikipedia.en:Subatomic_particle {source="wikipedia.en"}
is_a: BFO:0000040 ! material entity
disjoint_from: COB:0000011 ! atom
[Term]
id: CHEBI:36343
name: composite particle
def: "A subatomic particle known to have substructure (i.e. consisting of smaller particles)." []
subset: 3:STAR
synonym: "composite particles" RELATED [chebi]
is_a: CHEBI:36342 ! subatomic particle
[Term]
id: CHEBI:36344
name: hadron
def: "Hadron is a subatomic particle which experiences the strong force." []
subset: 3:STAR
synonym: "hadrons" RELATED [chebi]
is_a: CHEBI:36343 ! composite particle
[Term]
id: CHEBI:36347
name: nuclear particle
def: "A nucleus or any of its constituents in any of their energy states." []
subset: 3:STAR
synonym: "nuclear particle" EXACT IUPAC:NAME [IUPAC]
synonym: "nuclear particle" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:36342 ! subatomic particle
[Term]
id: CHEBI:36357
name: polyatomic entity
def: "Any molecular entity consisting of more than one atom." []
subset: 3:STAR
synonym: "polyatomic entities" RELATED [chebi]
is_a: CHEBI:23367 ! molecular entity
relationship: has_part CHEBI:24433 ! group
[Term]
id: CHEBI:36358
name: polyatomic ion
def: "An ion consisting of more than one atom." []
subset: 3:STAR
synonym: "polyatomic ions" RELATED [chebi]
is_a: CHEBI:24870 ! ion
is_a: CHEBI:36357 ! polyatomic entity
[Term]
id: CHEBI:36359
name: phosphorus oxoacid derivative
subset: 3:STAR
synonym: "phosphorus oxoacid derivative" RELATED [chebi]
is_a: CHEBI:33241 ! oxoacid derivative
is_a: CHEBI:36360 ! phosphorus oxoacids and derivatives
relationship: RO:0018038 CHEBI:33457 ! has functional parent phosphorus oxoacid
[Term]
id: CHEBI:36360
name: phosphorus oxoacids and derivatives
subset: 1:STAR
synonym: "phosphorus oxoacids and derivatives" RELATED [chebi]
is_a: CHEBI:26082 ! phosphorus molecular entity
[Term]
id: CHEBI:36364
name: alkaline earth salt
subset: 3:STAR
synonym: "alkaline earth salts" RELATED [chebi]
is_a: CHEBI:24866 ! salt
is_a: CHEBI:33299 ! alkaline earth molecular entity
[Term]
id: CHEBI:36498
name: galactosylceramide
alt_id: CHEBI:13641
def: "Any of the cerebrosides in which the monosaccharide head group is galactose." []
subset: 3:STAR
synonym: "a D-galactosylceramide" RELATED [uniprot_ft]
synonym: "Cerebroside" RELATED [kegg.compound]
synonym: "D-Galactosyl-N-acylsphingosine" RELATED [kegg.compound]
synonym: "D-Galactosylceramide" RELATED [kegg.compound]
synonym: "Galactocerebroside" RELATED [kegg.compound]
synonym: "galactocerebroside" RELATED [chebi]
synonym: "galactocerebrosides" RELATED [chebi]
synonym: "galactosylceramides" RELATED [chebi]
xref: kegg.compound:C02686 {source="kegg.compound"}
xref: kegg.glycan:G11121 {source="kegg.glycan"}
xref: pubmed:16758576 {source="pubmed"}
xref: pubmed:17855742 {source="pubmed"}
xref: pubmed:2088646 {source="pubmed"}
xref: pubmed:23065187 {source="pubmed"}
xref: pubmed:23446636 {source="pubmed"}
xref: pubmed:23650721 {source="pubmed"}
xref: pubmed:25947378 {source="pubmed"}
xref: pubmed:26058499 {source="pubmed"}
xref: pubmed:26907993 {source="pubmed"}
xref: pubmed:27786470 {source="pubmed"}
is_a: CHEBI:23079 ! cerebroside
is_a: CHEBI:5254 ! galactolipid
is_a: CHEBI:62941 ! glycosylceramide
[Term]
id: CHEBI:36586
name: carbonyl compound
def: "Any compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives." []
subset: 3:STAR
synonym: "carbonyl compounds" EXACT IUPAC:NAME [IUPAC]
synonym: "carbonyl compounds" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:36587 ! organic oxo compound
is_a: CHEBI:36963 ! organooxygen compound
relationship: has_part CHEBI:23019 ! carbonyl group
[Term]
id: CHEBI:36587
name: organic oxo compound
def: "Organic compounds containing an oxygen atom, =O, doubly bonded to carbon or another element." []
subset: 3:STAR
synonym: "organic oxo compounds" RELATED [chebi]
synonym: "oxo compounds" EXACT IUPAC:NAME [IUPAC]
synonym: "oxo compounds" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:72695 ! organic molecule
relationship: has_part CHEBI:46629 ! oxo group
[Term]
id: CHEBI:36699
name: corticosteroid hormone
def: "Any of a class of steroid hormones that are produced in the adrenal cortex." []
subset: 3:STAR
synonym: "adrenal cortex hormones" RELATED [chebi]
synonym: "corticosteroid hormones" RELATED [chebi]
is_a: CHEBI:26764 ! steroid hormone
is_a: CHEBI:50858 ! corticosteroid
[Term]
id: CHEBI:36700
name: phosphocholines
def: "Any compound having phosphocholine as part of its structure." []
subset: 3:STAR
synonym: "choline phosphates" RELATED [chebi]
synonym: "O-phosphocholines" RELATED [chebi]
synonym: "phosphorylcholines" RELATED [chebi]
is_a: CHEBI:23213 ! choline ester
is_a: CHEBI:23217 ! cholines
is_a: CHEBI:25703 ! organic phosphate
is_a: CHEBI:37734 ! phosphoric ester
[Term]
id: CHEBI:36735
name: biladienes
def: "Compounds based on a biladiene skeleton." []
subset: 3:STAR
is_a: CHEBI:25046 ! linear tetrapyrrole
[Term]
id: CHEBI:36756
name: farnesane
def: "A sesquiterpene that is dodecane substituted by methyl groups at positions 2, 6 and 10." []
subset: 3:STAR
synonym: "2,6,10-trimethyldodecane" EXACT IUPAC:NAME [IUPAC]
synonym: "2,6,10-trimethyldodecane" RELATED IUPAC:NAME [iupac]
synonym: "Farnesan" RELATED [nist]
synonym: "farnesane" RELATED [nist]
xref: cas:3891-98-3 {source="cas"}
xref: lipidmaps:LMPR0103010000 {source="lipidmaps"}
xref: metacyc.compound:CPD-8764 {source="metacyc.compound"}
xref: patent:US2008098645 {source="patent"}
xref: patent:US7399323 {source="patent"}
xref: reaxys:1719672 {source="reaxys"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:18310 ! alkane
is_a: CHEBI:35189 ! sesquiterpene
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
[Term]
id: CHEBI:36757
name: farnesane sesquiterpenoid
subset: 3:STAR
synonym: "farnesane sesquiterpenoid" RELATED [chebi]
synonym: "farnesane sesquiterpenoids" RELATED [chebi]
is_a: CHEBI:26658 ! sesquiterpenoid
relationship: RO:0018040 CHEBI:36756 ! has parent hydride farnesane
[Term]
id: CHEBI:36838
name: 17-hydroxy steroid
def: "A hydroxy steroid carrying a hydroxy group at position 17." []
subset: 3:STAR
synonym: "17-hydroxy steroids" RELATED [chebi]
is_a: CHEBI:35350 ! hydroxy steroid
[Term]
id: CHEBI:36841
name: 11-hydroxy steroid
subset: 3:STAR
synonym: "11-hydroxy steroids" RELATED [chebi]
is_a: CHEBI:35350 ! hydroxy steroid
[Term]
id: CHEBI:36885
name: 20-oxo steroid
def: "An oxo steroid carrying an oxo group at position 20." []
subset: 3:STAR
synonym: "20-oxo steroids" RELATED [chebi]
is_a: CHEBI:35789 ! oxo steroid
[Term]
id: CHEBI:36887
name: 18-oxo steroid
subset: 3:STAR
synonym: "18-oxo steroids" RELATED [chebi]
is_a: CHEBI:35789 ! oxo steroid
[Term]
id: CHEBI:36902
name: chalcogen hydride
subset: 3:STAR
synonym: "chalcogen hydride" RELATED [chebi]
synonym: "chalcogen hydrides" RELATED [chebi]
is_a: CHEBI:33242 ! inorganic hydride
is_a: CHEBI:33304 ! chalcogen molecular entity
[Term]
id: CHEBI:36914
name: inorganic ion
subset: 3:STAR
synonym: "inorganic ions" RELATED [chebi]
is_a: CHEBI:24835 ! inorganic molecular entity
is_a: CHEBI:24870 ! ion
[Term]
id: CHEBI:36915
name: inorganic cation
subset: 3:STAR
synonym: "inorganic cations" RELATED [chebi]
is_a: CHEBI:36914 ! inorganic ion
is_a: CHEBI:36916 ! cation
[Term]
id: CHEBI:36916
name: cation
alt_id: CHEBI:23058
alt_id: CHEBI:3473
def: "A monoatomic or polyatomic species having one or more elementary charges of the proton." []
subset: 3:STAR
synonym: "Cation" EXACT [KEGG_COMPOUND]
synonym: "Cation" RELATED [kegg.compound]
synonym: "cation" EXACT IUPAC:NAME [IUPAC]
synonym: "cation" RELATED IUPAC:NAME [chebi, iupac]
synonym: "cationes" RELATED [chebi]
synonym: "cations" RELATED [chebi]
synonym: "Kation" RELATED [chebi]
synonym: "Kationen" RELATED [chebi]
xref: kegg.compound:C01373 {source="kegg.compound"}
is_a: CHEBI:24870 ! ion
[Term]
id: CHEBI:36961
name: chalcocarbonic acid
subset: 3:STAR
synonym: "chalcocarbonic acid" RELATED [chebi]
synonym: "chalcocarbonic acids" EXACT IUPAC:NAME [IUPAC]
synonym: "chalcocarbonic acids" RELATED IUPAC:NAME [chebi, iupac]
is_a: CHEBI:36962 ! organochalcogen compound
[Term]
id: CHEBI:36962
name: organochalcogen compound
def: "An organochalcogen compound is a compound containing at least one carbon-chalcogen bond." []
subset: 3:STAR
synonym: "organochalcogen compound" RELATED [chebi]
synonym: "organochalcogen compounds" RELATED [chebi]
is_a: CHEBI:33285 ! heteroorganic entity
is_a: CHEBI:33304 ! chalcogen molecular entity
[Term]
id: CHEBI:36963
name: organooxygen compound
def: "An organochalcogen compound containing at least one carbon-oxygen bond." []
subset: 3:STAR
synonym: "organooxygen compound" RELATED [chebi]
synonym: "organooxygen compounds" RELATED [chebi]
xref: pubmed:17586126 {source="pubmed"}
is_a: CHEBI:25806 ! oxygen molecular entity
is_a: CHEBI:36962 ! organochalcogen compound
[Term]
id: CHEBI:36976
name: nucleotide
alt_id: CHEBI:13215
alt_id: CHEBI:13663
alt_id: CHEBI:7656
def: "A nucleotide is a nucleoside phosphate resulting from the condensation of the 3 or 5 hydroxy group of a nucleoside with phosphoric acid." []
subset: 3:STAR
synonym: "Nucleotide" RELATED [kegg.compound]
synonym: "nucleotides" RELATED [chebi]
xref: kegg.compound:C00215 {source="kegg.compound"}
xref: wikipedia.en:Nucleotide {source="wikipedia.en"}
is_a: CHEBI:25608 ! nucleoside phosphate
[Term]
id: CHEBI:37015
name: ribonucleoside 5'-phosphate
subset: 3:STAR
synonym: "ribonucleoside 5'-phosphates" RELATED [chebi]
is_a: CHEBI:16701 ! nucleoside 5'-phosphate
is_a: CHEBI:26561 ! ribonucleotide
[Term]
id: CHEBI:37022
name: amino-acid anion
subset: 3:STAR
synonym: "amino acid anion" RELATED [chebi]
synonym: "amino acid anions" RELATED [chebi]
synonym: "amino-acid anions" RELATED [chebi]
is_a: CHEBI:29067 ! carboxylic acid anion
is_a: CHEBI:35352 ! organonitrogen compound
relationship: RO:0018033 CHEBI:33709 ! is deprotonated form of amino acid
[Term]
id: CHEBI:37038
name: purine ribonucleoside 5'-diphosphate
subset: 3:STAR
synonym: "purine ribonucleoside 5'-diphosphates" RELATED [chebi]
is_a: CHEBI:26396 ! purine ribonucleoside diphosphate
is_a: CHEBI:26400 ! purine ribonucleotide
is_a: CHEBI:37075 ! ribonucleoside 5'-diphosphate
[Term]
id: CHEBI:37045
name: purine ribonucleoside 5'-triphosphate
subset: 3:STAR
synonym: "purine ribonucleoside 5'-triphosphates" RELATED [chebi]
is_a: CHEBI:26398 ! purine ribonucleoside triphosphate
is_a: CHEBI:26400 ! purine ribonucleotide
is_a: CHEBI:37076 ! ribonucleoside 5'-triphosphate
[Term]
id: CHEBI:37075
name: ribonucleoside 5'-diphosphate
subset: 3:STAR
synonym: "ribonucleoside 5'-diphosphates" RELATED [chebi]
is_a: CHEBI:37015 ! ribonucleoside 5'-phosphate
[Term]
id: CHEBI:37076
name: ribonucleoside 5'-triphosphate
subset: 3:STAR
synonym: "ribonucleoside 5'-triphosphates" RELATED [chebi]
is_a: CHEBI:37015 ! ribonucleoside 5'-phosphate
[Term]
id: CHEBI:37096
name: adenosine 5'-phosphate
subset: 3:STAR
synonym: "adenosine 5'-phosphates" RELATED [chebi]
is_a: CHEBI:22256 ! adenosine phosphate
[Term]
id: CHEBI:37163
name: glucan
alt_id: CHEBI:24255
alt_id: CHEBI:5392
def: "A polysaccharide composed of glucose residues." []
subset: 3:STAR
synonym: "Glucan" EXACT [KEGG_COMPOUND]
synonym: "Glucan" RELATED [kegg.compound]
synonym: "glucan" EXACT IUPAC:NAME [IUPAC]
synonym: "glucan" RELATED IUPAC:NAME [iupac]
synonym: "glucans" RELATED [chebi]
xref: cas:9037-91-6 {source="cas"}
xref: kegg.compound:C01379 {source="kegg.compound"}
is_a: CHEBI:37164 ! homopolysaccharide
[Term]
id: CHEBI:37164
name: homopolysaccharide
def: "Glycans composed of a single type of monosaccharide residue. They are named by replacing the ending '-ose' of the sugar by '-an'." []
subset: 3:STAR
synonym: "homoglycan" RELATED [iupac]
synonym: "homopolysaccharide" EXACT IUPAC:NAME [IUPAC]
synonym: "homopolysaccharide" RELATED IUPAC:NAME [iupac]
synonym: "homopolysaccharides" RELATED [chebi]
is_a: CHEBI:18154 ! polysaccharide
[Term]
id: CHEBI:37175
name: organic hydride
subset: 3:STAR
synonym: "organic hydrides" RELATED [chebi]
is_a: CHEBI:33692 ! hydrides
[Term]
id: CHEBI:37176
name: mononuclear parent hydride
subset: 3:STAR
synonym: "mononuclear hydride" RELATED [chebi]
synonym: "mononuclear hydrides" RELATED [iupac]
synonym: "mononuclear parent hydrides" EXACT IUPAC:NAME [IUPAC]
synonym: "mononuclear parent hydrides" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:33692 ! hydrides
[Term]
id: CHEBI:37246
name: elemental sodium
subset: 3:STAR
is_a: CHEBI:26712 ! sodium molecular entity
[Term]
id: CHEBI:37247
name: elemental potassium
subset: 3:STAR
is_a: CHEBI:26217 ! potassium molecular entity
[Term]
id: CHEBI:37395
name: mucopolysaccharide
alt_id: CHEBI:25425
alt_id: CHEBI:7011
def: "Any of the group of polysaccharides composed of alternating units from uronic acids and glycosamines, and commonly partially esterified with sulfuric acid." []
subset: 3:STAR
synonym: "mucopolisacarido" RELATED [chebi]
synonym: "mucopolisacaridos" RELATED [iupac]
synonym: "Mucopolysaccharid" RELATED [chebi]
synonym: "Mucopolysaccharide" RELATED [kegg.compound]
synonym: "mucopolysaccharides" EXACT IUPAC:NAME [IUPAC]
synonym: "mucopolysaccharides" RELATED IUPAC:NAME [iupac]
synonym: "Mukopolysaccharid" RELATED [chebi]
xref: kegg.compound:C05114 {source="kegg.compound"}
is_a: CHEBI:18085 ! glycosaminoglycan
[Term]
id: CHEBI:37397
name: chondroitin sulfate
alt_id: CHEBI:23224
alt_id: CHEBI:3676
def: "Any of a class of 10—60 kDa glycosaminoglycan sulfates, widely distributed in cartilage and other mammalian connective tissues." []
subset: 3:STAR
synonym: "chondroitin polysulfate" RELATED [chemidplus]
synonym: "Chondroitin sulfate" RELATED [kegg.compound]
synonym: "chondroitin sulfates" RELATED [chemidplus]
synonym: "chondroitin sulfuric acid" RELATED [chemidplus]
synonym: "chondroitin sulphate" RELATED [chemidplus]
synonym: "Chondroitinsulfat" RELATED [chebi]
xref: cas:9007-28-7 {source="cas"}
xref: kegg.compound:C00607 {source="kegg.compound"}
xref: pubmed:11514091 {source="pubmed"}
xref: pubmed:7538297 {source="pubmed"}
is_a: CHEBI:35722 ! sulfated glycosaminoglycan
is_a: CHEBI:37395 ! mucopolysaccharide
relationship: RO:0018038 CHEBI:16137 ! has functional parent chondroitin D-glucuronate
[Term]
id: CHEBI:37527
name: acid
alt_id: CHEBI:13800
alt_id: CHEBI:13801
alt_id: CHEBI:22209
alt_id: CHEBI:2426
def: "An acid is a molecular entity capable of donating a hydron (Brønsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid)." []
subset: 3:STAR
synonym: "Acid" EXACT [KEGG_COMPOUND]
synonym: "Acid" RELATED [kegg.compound]
synonym: "acid" EXACT IUPAC:NAME [IUPAC]
synonym: "acid" RELATED IUPAC:NAME [iupac]
synonym: "acide" RELATED [iupac]
synonym: "acido" RELATED [chebi]
synonym: "acids" RELATED [chebi]
synonym: "Saeure" RELATED [chebi]
synonym: "Saeuren" RELATED [chebi]
xref: kegg.compound:C00174 {source="kegg.compound"}
is_a: CHEBI:51086 ! chemical role
[Term]
id: CHEBI:37577
name: heteroatomic molecular entity
def: "A molecular entity consisting of two or more chemical elements." []
subset: 3:STAR
synonym: "chemical compound" RELATED [chebi]
synonym: "heteroatomic molecular entities" RELATED [chebi]
is_a: CHEBI:36357 ! polyatomic entity
[Term]
id: CHEBI:37622
name: carboxamide
alt_id: CHEBI:35354
alt_id: CHEBI:35355
def: "An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the ‒C(=O)NH2 group including its carbon atom." []
subset: 3:STAR
synonym: "carboxamides" EXACT IUPAC:NAME [IUPAC]
synonym: "carboxamides" RELATED IUPAC:NAME [chebi, iupac]
synonym: "primary carboxamide" RELATED [chebi]
is_a: CHEBI:33256 ! primary amide
is_a: CHEBI:35352 ! organonitrogen compound
is_a: CHEBI:36963 ! organooxygen compound
relationship: has_part CHEBI:23004 ! carbamoyl group
[Term]
id: CHEBI:37661
name: glucopyranose
subset: 3:STAR
synonym: "glucopyranose" EXACT IUPAC:NAME [IUPAC]
synonym: "glucopyranose" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:17234 ! glucose
[Term]
id: CHEBI:37734
name: phosphoric ester
alt_id: CHEBI:26019
subset: 1:STAR
synonym: "phosphate esters" RELATED [chebi]
synonym: "phosphoric esters" RELATED [chebi]
is_a: CHEBI:26079 ! phosphoric acid derivative
is_a: CHEBI:35701 ! ester
[Term]
id: CHEBI:37788
name: O(4)-phospho-L-tyrosine
alt_id: CHEBI:21991
alt_id: CHEBI:45080
alt_id: CHEBI:45158
alt_id: CHEBI:45187
alt_id: CHEBI:45209
alt_id: CHEBI:8171
def: "A non-proteinogenic L-α-amino acid that is L-tyrosine phosphorylated at the phenolic hydroxy group." []
subset: 3:STAR
synonym: "O(4)-phosphono-L-tyrosine" EXACT IUPAC:NAME [IUPAC]
synonym: "O(4)-phosphono-L-tyrosine" RELATED IUPAC:NAME [iupac]
synonym: "O-phospho-L-tyrosine" RELATED [chebi]
synonym: "O-phosphono-L-tyrosine" RELATED [chebi]
synonym: "O-phosphotyrosine" RELATED [chebi]
synonym: "Phosphonotyrosine" RELATED [kegg.compound]
synonym: "Phosphotyrosine" RELATED [kegg.compound]
synonym: "tyrosine phosphate" RELATED [chebi]
xref: cas:21820-51-9 {source="cas"}
xref: drugbank:DB01962 {source="drugbank"}
xref: kegg.compound:C06501 {source="kegg.compound"}
xref: pdb-ccd:PTR {source="pdb-ccd"}
xref: pubmed:11400052 {source="pubmed"}
xref: pubmed:11782793 {source="pubmed"}
xref: pubmed:11992381 {source="pubmed"}
xref: pubmed:1382614 {source="pubmed"}
xref: pubmed:15022197 {source="pubmed"}
xref: pubmed:16240095 {source="pubmed"}
xref: pubmed:16926509 {source="pubmed"}
xref: pubmed:1718554 {source="pubmed"}
xref: pubmed:18627164 {source="pubmed"}
xref: pubmed:2415179 {source="pubmed"}
xref: pubmed:2477282 {source="pubmed"}
xref: pubmed:2576051 {source="pubmed"}
xref: pubmed:30398859 {source="pubmed"}
xref: pubmed:7678776 {source="pubmed"}
xref: pubmed:8041296 {source="pubmed"}
xref: pubmed:8603380 {source="pubmed"}
xref: pubmed:9784397 {source="pubmed"}
xref: reaxys:3150815 {source="reaxys"}
is_a: CHEBI:27177 ! L-tyrosine derivative
is_a: CHEBI:74956 ! O(4)-phosphotyrosine
is_a: CHEBI:83822 ! non-proteinogenic L-alpha-amino acid
relationship: RO:0000087 CHEBI:60816 ! has role immunogen
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0018034 CHEBI:62338 ! is protonated form of O(4)-phosphonato-L-tyrosine(2-)
relationship: RO:0018039 CHEBI:74959 ! is enantiomer of O(4)-phospho-D-tyrosine
[Term]
id: CHEBI:37826
name: sulfuric acid derivative
subset: 3:STAR
synonym: "sulfuric acid derivative" RELATED [chebi]
synonym: "sulfuric acid derivatives" RELATED [chebi]
is_a: CHEBI:33424 ! sulfur oxoacid derivative
relationship: RO:0018038 CHEBI:26836 ! has functional parent sulfuric acid
[Term]
id: CHEBI:37838
name: carboacyl group
def: "A carboacyl group is a group formed by loss of at least one OH from the carboxy group of a carboxylic acid." []
subset: 3:STAR
synonym: "carboacyl groups" EXACT IUPAC:NAME [IUPAC]
synonym: "carboacyl groups" RELATED IUPAC:NAME [iupac]
synonym: "carboxylic acyl group" EXACT IUPAC:NAME [IUPAC]
synonym: "carboxylic acyl group" RELATED IUPAC:NAME [iupac]
synonym: "carboxylic acyl groups" RELATED [iupac]
is_a: CHEBI:22221 ! acyl group
relationship: RO:0018037 CHEBI:33575 ! is substitutent group from carboxylic acid
[Term]
id: CHEBI:37886
name: adrenergic agonist
def: "An agent that selectively binds to and activates adrenergic receptors." []
subset: 3:STAR
synonym: "adrenergic agonists" RELATED [chebi]
synonym: "adrenergic receptor agonist" RELATED [chebi]
synonym: "adrenoceptor agonists" RELATED [iuphar]
synonym: "adrenomimetic" RELATED [chebi]
synonym: "adrenomimetics" RELATED [chebi]
is_a: CHEBI:37962 ! adrenergic agent
[Term]
id: CHEBI:37962
name: adrenergic agent
def: "Any agent that acts on an adrenergic receptor or affects the life cycle of an adrenergic transmitter." []
subset: 3:STAR
synonym: "adrenergic agents" RELATED [chebi]
synonym: "adrenergic drug" RELATED [chebi]
synonym: "adrenergic drugs" RELATED [chebi]
synonym: "adrenergic neuron agents" RELATED [chebi]
synonym: "adrenergics" RELATED [chebi]
is_a: CHEBI:35942 ! neurotransmitter agent
[Term]
id: CHEBI:38070
name: anti-arrhythmia drug
def: "A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres." []
subset: 3:STAR
synonym: "anti-arrhythmia agent" RELATED [chebi]
synonym: "antiarrhythmic agent" RELATED [chebi]
is_a: CHEBI:35554 ! cardiovascular drug
[Term]
id: CHEBI:38077
name: polypyrrole
def: "A compound composed of two or more pyrrole units." []
subset: 3:STAR
synonym: "poly(pyrrole)s" RELATED [chebi]
synonym: "polypyrroles" RELATED [chebi]
synonym: "PPys" RELATED [chebi]
xref: beilstein:8538310 {source="beilstein"}
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound
[Term]
id: CHEBI:38101
name: organonitrogen heterocyclic compound
def: "Any organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms." []
subset: 3:STAR
synonym: "heterocyclic organonitrogen compounds" RELATED [chebi]
synonym: "organonitrogen heterocyclic compounds" RELATED [chebi]
is_a: CHEBI:24532 ! organic heterocyclic compound
is_a: CHEBI:35352 ! organonitrogen compound
[Term]
id: CHEBI:38104
name: oxacycle
def: "Any organic heterocyclic compound containing at least one ring oxygen atom." []
subset: 3:STAR
synonym: "heterocyclic organooxygen compounds" RELATED [chebi]
synonym: "organooxygen heterocyclic compounds" RELATED [chebi]
synonym: "oxacycles" RELATED [chebi]
xref: pubmed:17134300 {source="pubmed"}
is_a: CHEBI:24532 ! organic heterocyclic compound
is_a: CHEBI:36963 ! organooxygen compound
[Term]
id: CHEBI:38147
name: cardiotonic drug
def: "A drug that has a strengthening effect on the heart or that can increase cardiac output." []
subset: 3:STAR
synonym: "cardiotonic drugs" RELATED [chebi]
is_a: CHEBI:35554 ! cardiovascular drug
[Term]
id: CHEBI:38166
name: organic heteropolycyclic compound
alt_id: CHEBI:25429
alt_id: CHEBI:38075
subset: 3:STAR
synonym: "organic heteropolycyclic compounds" RELATED [chebi]
is_a: CHEBI:24532 ! organic heterocyclic compound
is_a: CHEBI:33671 ! heteropolycyclic compound
[Term]
id: CHEBI:38179
name: monocyclic heteroarene
subset: 3:STAR
synonym: "monocyclic heteroarenes" RELATED [chebi]
is_a: CHEBI:33833 ! heteroarene
[Term]
id: CHEBI:38180
name: polycyclic heteroarene
subset: 3:STAR
synonym: "polycyclic heteroarenes" RELATED [chebi]
is_a: CHEBI:33833 ! heteroarene
[Term]
id: CHEBI:38323
name: cholinergic drug
def: "Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons." []
subset: 3:STAR
synonym: "cholinergic agent" RELATED [chebi]
synonym: "cholinergic drugs" RELATED [chebi]
synonym: "cholinomimetic" RELATED [chebi]
is_a: CHEBI:35942 ! neurotransmitter agent
[Term]
id: CHEBI:38324
name: cholinergic agonist
def: "Any drug that binds to and activates cholinergic receptors." []
subset: 3:STAR
synonym: "acetylcholine agonist" RELATED [chebi]
synonym: "acetylcholine agonists" RELATED [chebi]
synonym: "acetylcholine receptor agonist" RELATED [iuphar]
synonym: "cholinergic agonists" RELATED [chebi]
synonym: "cholinomimetic" RELATED [chebi]
synonym: "cholinomimetics" RELATED [chebi]
is_a: CHEBI:38323 ! cholinergic drug
[Term]
id: CHEBI:38325
name: muscarinic agonist
def: "Any drug that binds to and activates a muscarinic cholinergic receptor." []
subset: 3:STAR
synonym: "muscarinic acetylcholine receptor agonist" RELATED [chebi]
synonym: "muscarinic agonists" RELATED [chebi]
synonym: "muscarinic cholinergic agonist" RELATED [chebi]
synonym: "muscarinic cholinergic agonists" RELATED [chebi]
is_a: CHEBI:38324 ! cholinergic agonist
[Term]
id: CHEBI:38560
name: simple protein
subset: 3:STAR
synonym: "simple proteins" RELATED [chebi]
is_a: CHEBI:36080 ! protein
[Term]
id: CHEBI:38631
name: aminoalkylindole
alt_id: CHEBI:22503
alt_id: CHEBI:24792
subset: 3:STAR
synonym: "aminoalkylindoles" RELATED [chebi]
is_a: CHEBI:24828 ! indoles
[Term]
id: CHEBI:38700
name: organic sodium salt
subset: 3:STAR
synonym: "organic sodium salt" RELATED [chebi]
synonym: "organic sodium salts" RELATED [chebi]
is_a: CHEBI:24868 ! organic salt
is_a: CHEBI:26714 ! sodium salt
[Term]
id: CHEBI:38716
name: carboxylic acid dianion
def: "Any dianion containing at least one carboxy group." []
subset: 3:STAR
synonym: "carboxylic acid dianion" RELATED [chebi]
synonym: "carboxylic acid dianions" RELATED [chebi]
is_a: CHEBI:29067 ! carboxylic acid anion
[Term]
id: CHEBI:38867
name: anaesthetic
def: "Substance which produces loss of feeling or sensation." []
subset: 3:STAR
synonym: "anaesthetic" EXACT IUPAC:NAME [IUPAC]
synonym: "anaesthetic" RELATED IUPAC:NAME [iupac]
synonym: "anaesthetics" RELATED [chebi]
synonym: "Anaesthetika" RELATED [chebi]
synonym: "Anaesthetikum" RELATED [chebi]
synonym: "anesthetic agent" RELATED [chebi]
synonym: "anesthetic drug" RELATED [chebi]
synonym: "anesthetics" RELATED [chebi]
is_a: CHEBI:23888 ! drug
[Term]
id: CHEBI:3892
name: corticotropin
def: "A polypeptide hormone produced and secreted by the pituitary gland comprising 39 amino acid residues coupled in a linear sequence. The N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Corticotropin stimulates the cortex of the adrenal gland and boosts the synthesis of corticosteroids, mainly glucocorticoids but also sex steroids (androgens). It is used in the treatment of certain neurological disorders such as infantile spasms and multiple sclerosis, and diagnostically to investigate adrenocortical insufficiency." []
subset: 3:STAR
synonym: "ACTH" RELATED [kegg.compound]
synonym: "Adrenocorticotropic hormone" RELATED [kegg.compound]
synonym: "adrenocorticotropin" RELATED [chemidplus]
synonym: "corticotrofina" RELATED http://purl.obolibrary.org/obo/chebi/INN [chemidplus]
synonym: "corticotrophine" RELATED http://purl.obolibrary.org/obo/chebi/INN [chemidplus]
synonym: "corticotrophinum" RELATED http://purl.obolibrary.org/obo/chebi/INN [chemidplus]
synonym: "Corticotropin" RELATED [kegg.compound]
synonym: "corticotropin" RELATED http://purl.obolibrary.org/obo/chebi/INN [chemidplus]
synonym: "cortrophin" RELATED [chemidplus]
synonym: "L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-prolyl-L-alpha-aspartylglycyl-L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-L-alpha-glutamyl-L-seryl-L-alanyl-L-alpha-glutamyl-L-alanyl-L-phenylalanyl-L-prolyl-L-leucyl-L-alpha-glutamyl-L-phenylalanine" EXACT IUPAC:NAME [IUPAC]
synonym: "L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-prolyl-L-alpha-aspartylglycyl-L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-L-alpha-glutamyl-L-seryl-L-alanyl-L-alpha-glutamyl-L-alanyl-L-phenylalanyl-L-prolyl-L-leucyl-L-alpha-glutamyl-L-phenylalanine" RELATED IUPAC:NAME [iupac]
synonym: "SYSMEHFRWGKPVGKKRRPVKVYPDGAEDQLAEAFPLEF" RELATED [drugbank]
xref: cas:9002-60-2 {source="cas"}
xref: drugbank:DB01285 {source="drugbank"}
xref: drugcentral:4931 {source="drugcentral"}
xref: kegg.compound:C02017 {source="kegg.compound"}
xref: kegg.drug:D00146 {source="kegg.drug"}
is_a: CHEBI:15841 ! polypeptide
is_a: CHEBI:25905 ! peptide hormone
is_a: CHEBI:33694 ! biomacromolecule
relationship: RO:0000087 CHEBI:33295 ! has role diagnostic agent
[Term]
id: CHEBI:38958
name: indole alkaloid
alt_id: CHEBI:24795
alt_id: CHEBI:5901
def: "An alkaloid containing an indole skeleton." []
subset: 3:STAR
synonym: "Indole alkaloid" RELATED [kegg.compound]
synonym: "indole alkaloids" RELATED [chebi]
xref: kegg.compound:C06073 {source="kegg.compound"}
xref: wikipedia.en:Indole_alkaloid {source="wikipedia.en"}
is_a: CHEBI:22315 ! alkaloid
relationship: has_part CHEBI:73398 ! indole skeleton
[Term]
id: CHEBI:38975
name: methylbenzene
def: "Any alkylbenzene that is benzene substituted with one or more methyl groups." []
subset: 3:STAR
synonym: "methylbenzenes" RELATED [chebi]
is_a: CHEBI:38976 ! alkylbenzene
[Term]
id: CHEBI:38976
name: alkylbenzene
def: "A monocyclic arene that is benzene substituted with one or more alkyl groups." []
subset: 3:STAR
synonym: "alkylbenzene" RELATED [chebi]
synonym: "alkylbenzenes" RELATED [chebi]
synonym: "Alkylbenzol" RELATED [chebi]
is_a: CHEBI:22712 ! benzenes
is_a: CHEBI:33847 ! monocyclic arene
relationship: RO:0018040 CHEBI:16716 ! has parent hydride benzene
[Term]
id: CHEBI:39015
name: apolipoprotein
def: "Protein component on the surface of lipoprotein." []
subset: 3:STAR
synonym: "apolipoproteins" RELATED [chebi]
is_a: CHEBI:13850 ! apoprotein
[Term]
id: CHEBI:39022
name: inclusion compound
def: "A complex in which one component (the host) forms a cavity or, in the case of a crystal, a crystal lattice containing spaces in the shape of long tunnels or channels in which molecular entities of a second chemical species (the guest) are located. There is no covalent bonding between guest and host, the attraction being generally due to van der Waals forces." []
subset: 3:STAR
synonym: "compose d'inclusion" RELATED [iupac]
synonym: "compuesto de inclusion" RELATED [iupac]
synonym: "compuestos de inclusion" RELATED [iupac]
synonym: "inclusion complex" RELATED [iupac]
synonym: "inclusion compound" EXACT IUPAC:NAME [IUPAC]
synonym: "inclusion compound" RELATED IUPAC:NAME [iupac]
synonym: "inclusion compounds" RELATED [chebi]
is_a: CHEBI:50967 ! non-covalently-bound molecular entity
[Term]
id: CHEBI:39024
name: clathrate compound
def: "Inclusion compound in which the guest molecule is in a cage formed by the host molecule or by a lattice of host molecules." []
subset: 3:STAR
synonym: "cage compound" RELATED [iupac]
synonym: "Clathrat" RELATED [chebi]
synonym: "clathrate" RELATED [iupac]
synonym: "clathrate compounds" RELATED [chebi]
synonym: "clathrates" EXACT IUPAC:NAME [IUPAC]
synonym: "clathrates" RELATED IUPAC:NAME [iupac]
synonym: "Clathratverbindung" RELATED [chebi]
synonym: "clatrato" RELATED [iupac]
synonym: "clatratos" RELATED [iupac]
synonym: "compuesto de clatrato" RELATED [chebi]
synonym: "Klathrat" RELATED [chebi]
synonym: "Klathratverbindung" RELATED [chebi]
is_a: CHEBI:39022 ! inclusion compound
[Term]
id: CHEBI:39123
name: calcium cation
subset: 3:STAR
synonym: "calcium cation" RELATED [chebi]
synonym: "calcium cations" RELATED [chebi]
is_a: CHEBI:33513 ! alkaline earth cation
is_a: CHEBI:39124 ! calcium ion
[Term]
id: CHEBI:39124
name: calcium ion
subset: 3:STAR
synonym: "calcium ion" RELATED [chebi]
synonym: "calcium ions" RELATED [chebi]
is_a: CHEBI:25213 ! metal cation
is_a: CHEBI:35155 ! elemental calcium
[Term]
id: CHEBI:39141
name: Bronsted acid
def: "A molecular entity capable of donating a hydron to an acceptor (Brønsted base)." []
subset: 3:STAR
synonym: "acide de Bronsted" RELATED [iupac]
synonym: "Bronsted acid" EXACT IUPAC:NAME [IUPAC]
synonym: "Bronsted acid" RELATED IUPAC:NAME [iupac]
synonym: "Bronsted-Saeure" RELATED [chebi]
synonym: "donneur d'hydron" RELATED [iupac]
synonym: "hydron donor" RELATED [iupac]
is_a: CHEBI:17891 ! donor
is_a: CHEBI:37527 ! acid
[Term]
id: CHEBI:39142
name: Bronsted base
def: "A molecular entity capable of accepting a hydron from a donor (Brønsted acid)." []
subset: 3:STAR
synonym: "accepteur d'hydron" RELATED [iupac]
synonym: "base de Bronsted" RELATED [iupac]
synonym: "Bronsted base" EXACT IUPAC:NAME [IUPAC]
synonym: "Bronsted base" RELATED IUPAC:NAME [iupac]
synonym: "Bronsted-Base" RELATED [chebi]
synonym: "hydron acceptor" RELATED [iupac]
is_a: CHEBI:15339 ! acceptor
is_a: CHEBI:22695 ! base
[Term]
id: CHEBI:39144
name: Lewis base
def: "A molecular entity able to provide a pair of electrons and thus capable of forming a covalent bond with an electron-pair acceptor (Lewis acid), thereby producing a Lewis adduct." []
subset: 3:STAR
synonym: "base de Lewis" RELATED [iupac]
synonym: "donneur d'une paire d'electrons" RELATED [chebi]
synonym: "electron donor" RELATED [chebi]
synonym: "Lewis base" EXACT IUPAC:NAME [IUPAC]
synonym: "Lewis base" RELATED IUPAC:NAME [iupac]
synonym: "Lewis-Base" RELATED [chebi]
is_a: CHEBI:17891 ! donor
is_a: CHEBI:22695 ! base
[Term]
id: CHEBI:39418
name: straight-chain saturated fatty acid
def: "Any saturated fatty acid lacking a side-chain." []
subset: 3:STAR
synonym: "straight-chain saturated fatty acid" RELATED [chebi]
synonym: "straight-chain saturated fatty acids" RELATED [chebi]
xref: pubmed:15644336 {source="pubmed"}
is_a: CHEBI:26607 ! saturated fatty acid
is_a: CHEBI:59202 ! straight-chain fatty acid
relationship: RO:0018034 CHEBI:58954 ! is protonated form of straight-chain saturated fatty acid anion
[Term]
id: CHEBI:39745
name: dihydrogenphosphate
alt_id: CHEBI:29137
alt_id: CHEBI:39739
def: "A monovalent inorganic anion that consists of phosphoric acid in which one of the three OH groups has been deprotonated." []
subset: 3:STAR
synonym: "[PO2(OH)2](-)" RELATED [iupac]
synonym: "dihydrogen(tetraoxidophosphate)(1-)" EXACT IUPAC:NAME [IUPAC]
synonym: "dihydrogen(tetraoxidophosphate)(1-)" RELATED IUPAC:NAME [iupac]
synonym: "dihydrogenphosphate" EXACT IUPAC:NAME [IUPAC]
synonym: "dihydrogenphosphate" RELATED IUPAC:NAME [iupac]
synonym: "DIHYDROGENPHOSPHATE ION" RELATED [pdb-ccd]
synonym: "dihydrogentetraoxophosphate(1-)" EXACT IUPAC:NAME [IUPAC]
synonym: "dihydrogentetraoxophosphate(1-)" RELATED IUPAC:NAME [iupac]
synonym: "dihydrogentetraoxophosphate(V)" EXACT IUPAC:NAME [IUPAC]
synonym: "dihydrogentetraoxophosphate(V)" RELATED IUPAC:NAME [iupac]
synonym: "dihydroxidodioxidophosphate(1-)" EXACT IUPAC:NAME [IUPAC]
synonym: "dihydroxidodioxidophosphate(1-)" RELATED IUPAC:NAME [iupac]
synonym: "H2PO4(-)" RELATED [iupac]
xref: drugbank:DB02831 {source="drugbank"}
xref: gmelin:1999 {source="gmelin"}
xref: pdb-ccd:2HP {source="pdb-ccd"}
is_a: CHEBI:35780 ! phosphate ion
is_a: CHEBI:79389 ! monovalent inorganic anion
relationship: RO:0018033 CHEBI:26078 ! is deprotonated form of phosphoric acid
relationship: RO:0018034 CHEBI:43474 ! is protonated form of hydrogenphosphate
[Term]
id: CHEBI:3992
name: cyclic ketone
subset: 3:STAR
synonym: "Cyclic ketone" RELATED [kegg.compound]
synonym: "cyclic ketones" EXACT IUPAC:NAME [IUPAC]
synonym: "cyclic ketones" RELATED IUPAC:NAME [iupac]
xref: kegg.compound:C02019 {source="kegg.compound"}
is_a: CHEBI:17087 ! ketone
[Term]
id: CHEBI:40751
name: (S)-adrenaline
alt_id: CHEBI:30615
alt_id: CHEBI:40743
def: "The S-enantiomer of adrenaline." []
subset: 3:STAR
synonym: "(+)-3,4-dihydroxy-alpha-((methylamino)methyl)benzyl alcohol" RELATED [chemidplus]
synonym: "(+)-adrenaline" RELATED [iuphar]
synonym: "(S)-(+)-adrenaline" RELATED [chebi]
synonym: "(S)-4-(1-hydroxy-2-(methylamino)ethyl)pyrocatechol" RELATED [chemidplus]
synonym: "4-[(1S)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol" EXACT IUPAC:NAME [IUPAC]
synonym: "4-[(1S)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol" RELATED IUPAC:NAME [iupac]
synonym: "d-adrenaline" RELATED [chemidplus]
synonym: "d-epinephrine" RELATED [chemidplus]
xref: beilstein:2938799 {source="beilstein"}
xref: cas:150-05-0 {source="cas"}
xref: pdb-ccd:ALE {source="pdb-ccd"}
xref: reaxys:2938799 {source="reaxys"}
is_a: CHEBI:194548 ! 4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
relationship: RO:0018039 CHEBI:28918 ! is enantiomer of (R)-adrenaline
[Term]
id: CHEBI:41609
name: carbonate
alt_id: CHEBI:29201
alt_id: CHEBI:41605
subset: 3:STAR
synonym: "[CO3](2-)" RELATED [iupac]
synonym: "carbonate" RELATED [iupac]
synonym: "CARBONATE ION" RELATED [pdb-ccd]
synonym: "CO3(2-)" RELATED [chebi]
synonym: "Karbonat" RELATED [chebi]
synonym: "trioxidocarbonate(2-)" EXACT IUPAC:NAME [IUPAC]
synonym: "trioxidocarbonate(2-)" RELATED IUPAC:NAME [iupac]
xref: beilstein:3600898 {source="beilstein"}
xref: cas:3812-32-6 {source="cas"}
xref: gmelin:1559 {source="gmelin"}
xref: pdb-ccd:CO3 {source="pdb-ccd"}
is_a: CHEBI:35604 ! carbon oxoanion
relationship: RO:0018033 CHEBI:17544 ! is deprotonated form of hydrogencarbonate
[Term]
id: CHEBI:4167
name: D-glucopyranose
def: "A glucopyranose having D-configuration." []
subset: 3:STAR
synonym: "D-Glc" RELATED [chebi]
synonym: "D-Glcp" RELATED [chebi]
synonym: "D-glucopyranose" EXACT IUPAC:NAME [IUPAC]
synonym: "D-glucopyranose" RELATED IUPAC:NAME [iupac]
synonym: "D-Glucose" RELATED [kegg.compound]
synonym: "D-glucose" RELATED [uniprot_ft]
synonym: "Dextrose" RELATED [kegg.compound]
synonym: "Glc-OH" RELATED [chebi]
synonym: "Glucose" RELATED [kegg.compound]
synonym: "glucose" RELATED [chebi]
synonym: "Grape sugar" RELATED [kegg.compound]
xref: cas:2280-44-6 {source="cas"}
xref: glygen:G15021LG {source="glygen"}
xref: glytoucan:G15021LG {source="glytoucan"}
xref: gmelin:83256 {source="gmelin"}
xref: hmdb:HMDB0000122 {source="hmdb"}
xref: kegg.compound:C00031 {source="kegg.compound"}
xref: kegg.drug:D00009 {source="kegg.drug"}
xref: knapsack:C00001122 {source="knapsack"}
xref: metacyc.compound:D-Glucose {source="metacyc.compound"}
xref: pubmed:15987845 {source="pubmed"}
xref: pubmed:16901854 {source="pubmed"}
xref: pubmed:17336832 {source="pubmed"}
xref: pubmed:17439666 {source="pubmed"}
xref: pubmed:17928662 {source="pubmed"}
xref: pubmed:19913595 {source="pubmed"}
xref: pubmed:26812026 {source="pubmed"}
xref: pubmed:32619908 {source="pubmed"}
xref: pubmed:7524207 {source="pubmed"}
xref: pubmed:9140037 {source="pubmed"}
xref: pubmed:9501190 {source="pubmed"}
xref: pubmed:9506998 {source="pubmed"}
xref: pubmed:9545565 {source="pubmed"}
xref: reaxys:1281604 {source="reaxys"}
xref: wikipedia.en:Glucose {source="wikipedia.en"}
is_a: CHEBI:17634 ! D-glucose
is_a: CHEBI:37661 ! glucopyranose
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
[Term]
id: CHEBI:4194
name: D-hexose
def: "A hexose that has D-configuration at position 5." []
subset: 3:STAR
synonym: "a D-hexose" RELATED [uniprot_ft]
synonym: "D-hexopyranose" EXACT IUPAC:NAME [IUPAC]
synonym: "D-hexopyranose" RELATED IUPAC:NAME [iupac]
synonym: "D-Hexose" RELATED [kegg.compound]
synonym: "D-hexoses" RELATED [chebi]
xref: kegg.compound:C00738 {source="kegg.compound"}
is_a: CHEBI:18133 ! hexose
[Term]
id: CHEBI:42485
name: formyl group
alt_id: CHEBI:24089
alt_id: CHEBI:42480
subset: 3:STAR
synonym: "-CH(O)" RELATED [iupac]
synonym: "-CHO" RELATED [iupac]
synonym: "aldehyde group" EXACT IUPAC:NAME [IUPAC]
synonym: "aldehyde group" RELATED IUPAC:NAME [iupac]
synonym: "carbaldehyde" EXACT IUPAC:NAME [IUPAC]
synonym: "carbaldehyde" RELATED IUPAC:NAME [iupac]
synonym: "Fo" RELATED [iubmb]
synonym: "formyl" EXACT IUPAC:NAME [IUPAC]
synonym: "formyl" RELATED IUPAC:NAME [iupac]
synonym: "FORMYL GROUP" RELATED [pdb-ccd]
synonym: "H-CO-" RELATED [iupac]
synonym: "methanoyl" RELATED [iupac]
xref: pdb-ccd:FOR {source="pdb-ccd"}
is_a: CHEBI:27207 ! univalent carboacyl group
relationship: RO:0018037 CHEBI:30751 ! is substitutent group from formic acid
[Term]
id: CHEBI:43176
name: hydroxy group
alt_id: CHEBI:24706
alt_id: CHEBI:43171
subset: 3:STAR
synonym: "-OH" RELATED [iupac]
synonym: "hydroxy" EXACT IUPAC:NAME [IUPAC]
synonym: "hydroxy" RELATED IUPAC:NAME [iupac]
synonym: "HYDROXY GROUP" RELATED [pdb-ccd]
synonym: "hydroxy group" RELATED [uniprot_ft]
synonym: "hydroxyl" RELATED [chebi]
synonym: "hydroxyl group" RELATED [chebi]
xref: pdb-ccd:OH {source="pdb-ccd"}
is_a: CHEBI:33246 ! inorganic group
[Term]
id: CHEBI:43474
name: hydrogenphosphate
alt_id: CHEBI:29139
alt_id: CHEBI:43470
def: "A phosphate ion that is the conjugate base of dihydrogenphosphate." []
subset: 3:STAR
synonym: "[P(OH)O3](2-)" RELATED [molbase]
synonym: "[PO3(OH)](2-)" RELATED [iupac]
synonym: "HPO4(2-)" RELATED [iupac]
synonym: "hydrogen phosphate" RELATED [chebi]
synonym: "hydrogen(tetraoxidophosphate)(2-)" EXACT IUPAC:NAME [IUPAC]
synonym: "hydrogen(tetraoxidophosphate)(2-)" RELATED IUPAC:NAME [iupac]
synonym: "hydrogenphosphate" EXACT IUPAC:NAME [IUPAC]
synonym: "hydrogenphosphate" RELATED IUPAC:NAME [iupac]
synonym: "HYDROGENPHOSPHATE ION" RELATED [pdb-ccd]
synonym: "hydrogentetraoxophosphate(2-)" EXACT IUPAC:NAME [IUPAC]
synonym: "hydrogentetraoxophosphate(2-)" RELATED IUPAC:NAME [iupac]
synonym: "hydrogentetraoxophosphate(V)" EXACT IUPAC:NAME [IUPAC]
synonym: "hydrogentetraoxophosphate(V)" RELATED IUPAC:NAME [iupac]
synonym: "hydroxidotrioxidophosphate(2-)" EXACT IUPAC:NAME [IUPAC]
synonym: "hydroxidotrioxidophosphate(2-)" RELATED IUPAC:NAME [iupac]
synonym: "INORGANIC PHOSPHATE GROUP" RELATED [pdb-ccd]
synonym: "phosphate" RELATED [uniprot_ft]
xref: gmelin:1998 {source="gmelin"}
xref: molbase:1628 {source="molbase"}
xref: pdb-ccd:PI {source="pdb-ccd"}
xref: pdb-ccd:PO4 {source="pdb-ccd"}
is_a: CHEBI:35780 ! phosphate ion
is_a: CHEBI:79388 ! divalent inorganic anion
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0018033 CHEBI:39745 ! is deprotonated form of dihydrogenphosphate
relationship: RO:0018034 CHEBI:18367 ! is protonated form of phosphate(3-)
[Term]
id: CHEBI:456216
name: ADP(3-)
def: "A nucleoside 5'-diphosphate(3−) arising from deprotonation of all three diphosphate OH groups of adenosine 5'-diphosphate (ADP); major species present at pH 7.3." []
subset: 3:STAR
synonym: "5'-O-[(phosphonatooxy)phosphinato]adenosine" RELATED [chebi]
synonym: "adenosine 5'-diphosphate" EXACT IUPAC:NAME [IUPAC]
synonym: "adenosine 5'-diphosphate" RELATED IUPAC:NAME [iupac]
synonym: "ADP" RELATED [uniprot_ft]
synonym: "ADP trianion" RELATED [chebi]
xref: beilstein:3783669 {source="beilstein"}
xref: gmelin:341336 {source="gmelin"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:57930 ! nucleoside 5'-diphosphate(3-)
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
relationship: RO:0018033 CHEBI:16761 ! is deprotonated form of ADP
relationship: RO:0018033 CHEBI:87518 ! is deprotonated form of ADP(2-)
[Term]
id: CHEBI:45696
name: hydrogensulfate
alt_id: CHEBI:29199
alt_id: CHEBI:45693
subset: 3:STAR
synonym: "[SO3(OH)](-)" RELATED [iupac]
synonym: "HSO4(-)" RELATED [iupac]
synonym: "HYDROGEN SULFATE" RELATED [pdb-ccd]
synonym: "hydrogen(tetraoxidosulfate)(1-)" EXACT IUPAC:NAME [IUPAC]
synonym: "hydrogen(tetraoxidosulfate)(1-)" RELATED IUPAC:NAME [iupac]
synonym: "hydrogensulfate" RELATED [iupac]
synonym: "hydrogensulfate(1-)" EXACT IUPAC:NAME [IUPAC]
synonym: "hydrogensulfate(1-)" RELATED IUPAC:NAME [iupac]
synonym: "hydrogentetraoxosulfate(1-)" EXACT IUPAC:NAME [IUPAC]
synonym: "hydrogentetraoxosulfate(1-)" RELATED IUPAC:NAME [iupac]
synonym: "hydrogentetraoxosulfate(VI)" EXACT IUPAC:NAME [IUPAC]
synonym: "hydrogentetraoxosulfate(VI)" RELATED IUPAC:NAME [iupac]
synonym: "hydroxidotrioxidosulfate(1-)" EXACT IUPAC:NAME [IUPAC]
synonym: "hydroxidotrioxidosulfate(1-)" RELATED IUPAC:NAME [iupac]
xref: gmelin:2121 {source="gmelin"}
is_a: CHEBI:33482 ! sulfur oxoanion
relationship: RO:0018033 CHEBI:26836 ! is deprotonated form of sulfuric acid
relationship: RO:0018034 CHEBI:16189 ! is protonated form of sulfate
[Term]
id: CHEBI:46209
name: L-tyrosinal
alt_id: CHEBI:46188
def: "An amino aldehyde that is L-tyrosine in which the carboxy group has undergone formal redution to give the corrresponding aldehyde" []
subset: 3:STAR
synonym: "(2S)-2-amino-3-(4-hydroxyphenyl)propanal" EXACT IUPAC:NAME [IUPAC]
synonym: "(2S)-2-amino-3-(4-hydroxyphenyl)propanal" RELATED IUPAC:NAME [iupac]
synonym: "(2S)-2-amino-3-(p-hydroxyphenyl)propanal" RELATED [chebi]
synonym: "L-tyr aldehyde" RELATED [chebi]
synonym: "TYROSINAL" RELATED [pdb-ccd]
xref: metacyc.compound:CPD-21526 {source="metacyc.compound"}
xref: pdb-ccd:TYB {source="pdb-ccd"}
xref: pubmed:23281040 {source="pubmed"}
is_a: CHEBI:22492 ! amino aldehyde
is_a: CHEBI:33853 ! phenols
is_a: CHEBI:50994 ! primary amino compound
relationship: RO:0018033 CHEBI:141668 ! is deprotonated form of L-tyrosinal(1+)
[Term]
id: CHEBI:46629
name: oxo group
alt_id: CHEBI:29353
alt_id: CHEBI:44607
subset: 3:STAR
synonym: "=O" RELATED [iupac]
synonym: "oxo" EXACT IUPAC:NAME [IUPAC]
synonym: "oxo" RELATED IUPAC:NAME [iupac]
synonym: "OXO GROUP" RELATED [pdb-ccd]
xref: pdb-ccd:O {source="pdb-ccd"}
is_a: CHEBI:33246 ! inorganic group
[Term]
id: CHEBI:46662
name: mineral
def: "In general, a mineral is a chemical substance that is normally crystalline formed and has been formed as a result of geological processes. The term also includes metamict substances (naturally occurring, formerly crystalline substances whose crystallinity has been destroyed by ionising radiation) and can include naturally occurring amorphous substances that have never been crystalline ('mineraloids') such as georgite and calciouranoite as well as substances formed by the action of geological processes on bigenic compounds ('biogenic minerals')." []
subset: 3:STAR
synonym: "mineral" RELATED [chebi]
synonym: "Minerale" RELATED [chebi]
synonym: "minerales" RELATED [chebi]
synonym: "minerals" RELATED [chebi]
synonym: "mineraux" RELATED [chebi]
xref: wikipedia.en:Mineral {source="wikipedia.en"}
is_a: CHEBI:59999 ! chemical substance
[Term]
id: CHEBI:46721
name: carbonate salt
subset: 3:STAR
synonym: "carbonate salts" RELATED [chebi]
is_a: CHEBI:23016 ! carbonates
relationship: has_part CHEBI:41609 ! carbonate
[Term]
id: CHEBI:46723
name: phosphate mineral
subset: 3:STAR
synonym: "phosphate minerals" RELATED [chebi]
is_a: CHEBI:46662 ! mineral
[Term]
id: CHEBI:46787
name: solvent
def: "A liquid that can dissolve other substances (solutes) without any change in their chemical composition." []
subset: 3:STAR
synonym: "Loesungsmittel" RELATED [chebi]
synonym: "solvant" RELATED [chebi]
synonym: "solvents" RELATED [chebi]
xref: wikipedia.en:Solvent {source="wikipedia.en"}
is_a: CHEBI:33232 ! application
is_a: CHEBI:51086 ! chemical role
[Term]
id: CHEBI:46858
name: L-tyrosine residue
alt_id: CHEBI:29975
alt_id: CHEBI:46207
subset: 3:STAR
synonym: "L-tyrosine" EXACT [RESID]
synonym: "L-tyrosine" RELATED [resid]
synonym: "L-tyrosine acid residue" RELATED [jcbn]
synonym: "L-tyrosine residue" RELATED [jcbn, uniprot_ft]
synonym: "L-tyrosyl" RELATED [chebi]
synonym: "Tyr" RELATED [jcbn]
synonym: "Y" RELATED [jcbn]
xref: pdb-ccd:TYR_LL {source="pdb-ccd"}
xref: resid:AA0019 {source="resid"}
is_a: CHEBI:32789 ! tyrosine residue
is_a: CHEBI:33700 ! proteinogenic amino-acid residue
is_a: CHEBI:83228 ! L-alpha-amino acid residue
is_a: PR:000049928 ! amino-acid residue related to L-tyrosine
relationship: RO:0018037 CHEBI:17895 ! is substitutent group from L-tyrosine
relationship: RO:0018039 CHEBI:29976 ! is enantiomer of D-tyrosine residue
[Term]
id: CHEBI:46883
name: carboxy group
alt_id: CHEBI:23025
alt_id: CHEBI:41420
subset: 3:STAR
synonym: "-C(O)OH" RELATED [iupac]
synonym: "-CO2H" RELATED [chebi]
synonym: "-COOH" RELATED [iupac]
synonym: "carboxy" EXACT IUPAC:NAME [IUPAC]
synonym: "carboxy" RELATED IUPAC:NAME [iupac]
synonym: "CARBOXY GROUP" RELATED [pdb-ccd]
synonym: "carboxyl group" RELATED [chebi]
xref: pdb-ccd:FMT {source="pdb-ccd"}
is_a: CHEBI:33249 ! organyl group
[Term]
id: CHEBI:46997
name: L-ribose
def: "A ribose in which the chiral carbon atom furthest away from the aldehyde group (C4') has the same configuration as in L-glyceraldehyde." []
subset: 3:STAR
synonym: "L-Rib" RELATED [jcbn]
synonym: "L-ribo-pentose" EXACT IUPAC:NAME [IUPAC]
synonym: "L-ribo-pentose" RELATED IUPAC:NAME [iupac]
synonym: "L-ribose" EXACT IUPAC:NAME [IUPAC]
synonym: "L-ribose" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:33942 ! ribose
relationship: RO:0018039 CHEBI:16988 ! is enantiomer of D-ribose
[Term]
id: CHEBI:46998
name: ribofuranose
def: "A cyclic ribose having a 5-membered tetrahydrofuran ring; the predominant (C3'-endo) form of the two cyclic structures (the other is the \"C2'-endo\" form, having a 6-membered ring) adopted by ribose in aqueous solution." []
subset: 3:STAR
synonym: "rel-(3R,4S,5R)-5-(hydroxymethyl)tetrahydrofuran-2,3,4-triol" RELATED [iupac]
synonym: "ribofuranose" EXACT IUPAC:NAME [IUPAC]
synonym: "ribofuranose" RELATED IUPAC:NAME [iupac]
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:33942 ! ribose
relationship: RO:0000087 CHEBI:84735 ! has role algal metabolite
[Term]
id: CHEBI:47013
name: D-ribofuranose
alt_id: CHEBI:4233
alt_id: CHEBI:46999
def: "A ribofuranose having D-configuration." []
subset: 3:STAR
synonym: "(3R,4S,5R)-5-(hydroxymethyl)tetrahydrofuran-2,3,4-triol" RELATED [iupac]
synonym: "D-ribofuranose" EXACT IUPAC:NAME [IUPAC]
synonym: "D-ribofuranose" RELATED IUPAC:NAME [iupac]
synonym: "D-Ribose" EXACT [KEGG_COMPOUND]
synonym: "D-Ribose" RELATED [kegg.compound]
synonym: "D-ribose" RELATED [uniprot_ft]
synonym: "ribose" RELATED [chemidplus]
xref: beilstein:1904878 {source="beilstein"}
xref: cas:50-69-1 {source="cas"}
xref: cas:613-83-2 {source="cas"}
xref: glytoucan:G31080DL {source="glytoucan"}
xref: gmelin:364108 {source="gmelin"}
xref: kegg.compound:C00121 {source="kegg.compound"}
xref: patent:US2152662 {source="patent"}
xref: pubmed:9506998 {source="pubmed"}
xref: reaxys:1904878 {source="reaxys"}
is_a: CHEBI:16988 ! D-ribose
is_a: CHEBI:46998 ! ribofuranose
[Term]
id: CHEBI:47017
name: tetrahydrofuranol
subset: 3:STAR
synonym: "tetrahydrofuranols" RELATED [chebi]
is_a: CHEBI:26912 ! oxolanes
[Term]
id: CHEBI:47019
name: dihydroxytetrahydrofuran
subset: 3:STAR
synonym: "dihydroxytetrahydrofurans" RELATED [chebi]
is_a: CHEBI:47017 ! tetrahydrofuranol
[Term]
id: CHEBI:47622
name: acetate ester
alt_id: CHEBI:13244
alt_id: CHEBI:13799
alt_id: CHEBI:22189
alt_id: CHEBI:2406
def: "Any carboxylic ester where the carboxylic acid component is acetic acid." []
subset: 3:STAR
synonym: "acetate" RELATED [chebi]
synonym: "acetate esters" RELATED [chebi]
synonym: "acetates" RELATED [chebi]
synonym: "Acetic ester" RELATED [kegg.compound]
synonym: "Acetyl ester" RELATED [kegg.compound]
synonym: "acetyl esters" RELATED [chebi]
synonym: "an acetyl ester" RELATED [uniprot_ft]
xref: kegg.compound:C01883 {source="kegg.compound"}
xref: wikipedia.en:Acetate#Esters {source="wikipedia.en"}
is_a: CHEBI:33308 ! carboxylic ester
relationship: RO:0018038 CHEBI:15366 ! has functional parent acetic acid
[Term]
id: CHEBI:47788
name: 3-oxo steroid
alt_id: CHEBI:13607
alt_id: CHEBI:1653
alt_id: CHEBI:20182
alt_id: CHEBI:71186
def: "Any oxo steroid where an oxo substituent is located at position 3." []
subset: 3:STAR
synonym: "3-oxo steroids" RELATED [chebi]
synonym: "3-Oxosteroid" RELATED [kegg.compound]
synonym: "3-oxosteroids" RELATED [chebi]
synonym: "a 3-oxosteroid" RELATED [uniprot_ft]
xref: kegg.compound:C01876 {source="kegg.compound"}
xref: metacyc.compound:3-Oxosteroids {source="metacyc.compound"}
xref: pubmed:9811880 {source="pubmed"}
is_a: CHEBI:35789 ! oxo steroid
is_a: CHEBI:3992 ! cyclic ketone
[Term]
id: CHEBI:47882
name: cyclic polypyrrole
subset: 3:STAR
synonym: "cyclic polypyrroles" RELATED [chebi]
synonym: "macrocyclic polypyrroles" EXACT IUPAC:NAME [IUPAC]
synonym: "macrocyclic polypyrroles" RELATED IUPAC:NAME [iupac]
synonym: "polypyrrole macrocycles" RELATED [chebi]
is_a: CHEBI:38077 ! polypyrrole
[Term]
id: CHEBI:47891
name: steroid acid
def: "Any steroid substituted by at least one carboxy group." []
subset: 3:STAR
synonym: "steroid acids" RELATED [chebi]
is_a: CHEBI:35341 ! steroid
is_a: CHEBI:64709 ! organic acid
relationship: RO:0018034 CHEBI:50160 ! is protonated form of steroid acid anion
[Term]
id: CHEBI:47909
name: 3-oxo-Delta(4) steroid
alt_id: CHEBI:13604
alt_id: CHEBI:1626
alt_id: CHEBI:20157
def: "A 3-oxo steroid conjugated to a C=C double bond at the α,β position." []
subset: 3:STAR
synonym: "3-oxo Delta(4)-steroid" RELATED [chebi]
synonym: "3-oxo Delta(4)-steroids" RELATED [chebi]
synonym: "3-oxo-Delta(4) steroids" RELATED [chebi]
synonym: "3-Oxo-delta4-steroid" RELATED [kegg.compound]
synonym: "a 3-oxo-Delta(4)-steroid" RELATED [uniprot_ft]
xref: kegg.compound:C00619 {source="kegg.compound"}
xref: metacyc.compound:3-Oxo-Delta-4-Steroids {source="metacyc.compound"}
is_a: CHEBI:47788 ! 3-oxo steroid
is_a: CHEBI:51689 ! enone
relationship: has_part CHEBI:136849 ! 3-oxo-Delta(4)-steroid group
[Term]
id: CHEBI:48154
name: sulfur oxide
subset: 3:STAR
synonym: "oxides of sulfur" RELATED [chebi]
synonym: "Schwefeloxide" RELATED [chebi]
synonym: "sulfur oxides" RELATED [chebi]
is_a: CHEBI:24836 ! inorganic oxide
is_a: CHEBI:26835 ! sulfur molecular entity
[Term]
id: CHEBI:48354
name: polar solvent
def: "A solvent that is composed of polar molecules. Polar solvents can dissolve ionic compounds or ionisable covalent compounds." []
subset: 3:STAR
synonym: "polar solvent" EXACT IUPAC:NAME [IUPAC]
synonym: "polar solvent" RELATED IUPAC:NAME [iupac]
synonym: "polar solvents" RELATED [chebi]
is_a: CHEBI:46787 ! solvent
[Term]
id: CHEBI:48355
name: non-polar solvent
subset: 1:STAR
synonym: "non-polar solvents" RELATED [chebi]
is_a: CHEBI:46787 ! solvent
[Term]
id: CHEBI:48356
name: protic solvent
def: "A polar solvent that is capable of acting as a hydron (proton) donor." []
subset: 3:STAR
synonym: "protogenic solvent" EXACT IUPAC:NAME [IUPAC]
synonym: "protogenic solvent" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:39141 ! Bronsted acid
is_a: CHEBI:48354 ! polar solvent
[Term]
id: CHEBI:48359
name: protophilic solvent
def: "Solvent that is capable of acting as a hydron (proton) acceptor." []
subset: 3:STAR
synonym: "HBA solvent" RELATED [chebi]
synonym: "hydrogen bond acceptor solvent" RELATED [chebi]
synonym: "protophilic solvent" EXACT IUPAC:NAME [IUPAC]
synonym: "protophilic solvent" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:39142 ! Bronsted base
is_a: CHEBI:48354 ! polar solvent
[Term]
id: CHEBI:48360
name: amphiprotic solvent
def: "Self-ionizing solvent possessing both characteristics of Brønsted acids and bases." []
subset: 3:STAR
synonym: "amphiprotic solvent" EXACT IUPAC:NAME [IUPAC]
synonym: "amphiprotic solvent" RELATED IUPAC:NAME [iupac]
is_a: CHEBI:48356 ! protic solvent
is_a: CHEBI:48359 ! protophilic solvent
[Term]
id: CHEBI:48539
name: alpha-adrenergic drug
def: "Any drug that acts on an α-adrenergic receptor." []
subset: 3:STAR
synonym: "alpha-adrenergic drugs" RELATED [chebi]
is_a: CHEBI:37962 ! adrenergic agent
[Term]
id: CHEBI:48540
name: beta-adrenergic drug
def: "Any of the drugs that act on β-adrenergic receptors." []
subset: 3:STAR
synonym: "beta-adrenergic drugs" RELATED [chebi]
is_a: CHEBI:37962 ! adrenergic agent
[Term]
id: CHEBI:48560
name: dopaminergic agent
def: "A drug used for its effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons." []
subset: 3:STAR
synonym: "dopamine agent" RELATED [chebi]
synonym: "dopamine agents" RELATED [chebi]
synonym: "dopamine drug" RELATED [chebi]
synonym: "dopamine drugs" RELATED [chebi]
synonym: "dopaminergic agents" RELATED [chebi]
is_a: CHEBI:35942 ! neurotransmitter agent
[Term]
id: CHEBI:48578
name: radical scavenger
def: "A role played by a substance that can react readily with, and thereby eliminate, radicals." []
subset: 3:STAR
synonym: "free radical scavengers" RELATED [chebi]
synonym: "free-radical scavenger" RELATED [chebi]
is_a: CHEBI:22586 ! antioxidant
[Term]
id: CHEBI:48705
name: agonist
def: "Substance which binds to cell receptors normally responding to naturally occurring substances and which produces a response of its own." []
subset: 3:STAR
synonym: "agonist" EXACT IUPAC:NAME [IUPAC]
synonym: "agonist" RELATED IUPAC:NAME [iupac]
synonym: "agonista" RELATED [chebi]
synonym: "agoniste" RELATED [chebi]
synonym: "agonists" RELATED [chebi]
is_a: CHEBI:52210 ! pharmacological role
[Term]
id: CHEBI:48706
name: antagonist
def: "Substance that attaches to and blocks cell receptors that normally bind naturally occurring substances." []
subset: 3:STAR
synonym: "antagonist" EXACT IUPAC:NAME [IUPAC]
synonym: "antagonist" RELATED IUPAC:NAME [iupac]
synonym: "antagonista" RELATED [chebi]
synonym: "antagoniste" RELATED [chebi]
synonym: "antagonists" RELATED [chebi]
is_a: CHEBI:52210 ! pharmacological role
[Term]
id: CHEBI:48873
name: cholinergic antagonist
def: "Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists." []
subset: 3:STAR
synonym: "acetylcholine antagonists" RELATED [chebi]
synonym: "acetylcholine receptor antagonist" RELATED [iuphar]
synonym: "agent anticholinergique" RELATED [chebi]
synonym: "agente anticolinergico" RELATED [chebi]
synonym: "agentes anticolinergicos" RELATED [chebi]
synonym: "anticholinergic agents" RELATED [chebi]
synonym: "anticholinergics" RELATED [chebi]
synonym: "Anticholinergika" RELATED [chebi]
synonym: "Anticholinergikum" RELATED [chebi]
synonym: "anticholinergiques" RELATED [chebi]
synonym: "anticolinergicos" RELATED [chebi]
synonym: "cholinergic-blocking agents" RELATED [chebi]
is_a: CHEBI:38323 ! cholinergic drug
[Term]
id: CHEBI:49323
name: contraceptive drug
def: "A chemical substance that prevents or reduces the probability of conception." []
subset: 3:STAR
synonym: "contraceptive agent" RELATED [chebi]
synonym: "contraceptive drugs" RELATED [chebi]
is_a: CHEBI:50689 ! reproductive control drug
[Term]
id: CHEBI:49637
name: hydrogen atom
alt_id: CHEBI:24634
alt_id: CHEBI:49636
subset: 3:STAR
synonym: "1H" RELATED [iupac]
synonym: "H" RELATED [iupac]
synonym: "hidrogeno" RELATED [chebi]
synonym: "hydrogen" EXACT IUPAC:NAME [IUPAC]
synonym: "hydrogen" RELATED IUPAC:NAME [chebi, iupac]
synonym: "hydrogene" RELATED [chebi]
synonym: "Wasserstoff" RELATED [chebi]
xref: webelements:H {source="webelements"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:24835 ! inorganic molecular entity
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33559 ! s-block element atom
relationship: RO:0000087 CHEBI:33937 ! has role macronutrient
[Term]
id: CHEBI:50047
name: organic amino compound
def: "A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups." []
subset: 3:STAR
synonym: "organic amino compounds" RELATED [chebi]
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:35352 ! organonitrogen compound
relationship: RO:0000087 CHEBI:39142 ! has role Bronsted base
relationship: RO:0018040 CHEBI:16134 ! has parent hydride ammonia
[Term]
id: CHEBI:50112
name: sex hormone
def: "Any hormone that is responsible for controlling sexual characteristics and reproductive function." []
subset: 3:STAR
synonym: "Geschlechtshormon" RELATED [chebi]
synonym: "Geschlechtshormone" RELATED [chebi]
synonym: "hormone sexuelle" RELATED [chebi]
synonym: "hormones sexuelles" RELATED [chebi]
synonym: "sex hormones" RELATED [chebi]
synonym: "Sexualhormon" RELATED [chebi]
synonym: "Sexualhormone" RELATED [chebi]
is_a: CHEBI:24621 ! hormone
[Term]
id: CHEBI:50113
name: androgen
def: "A sex hormone that stimulates or controls the development and maintenance of masculine characteristics in vertebrates by binding to androgen receptors." []
subset: 3:STAR
synonym: "Androgen" RELATED [chebi]
synonym: "Androgene" RELATED [chebi]
synonym: "androgene" RELATED [chebi]
synonym: "androgenes" RELATED [chebi]
synonym: "androgeno" RELATED [chebi]
synonym: "androgenos" RELATED [chebi]
synonym: "androgens" RELATED [chebi]
is_a: CHEBI:50112 ! sex hormone
[Term]
id: CHEBI:50160
name: steroid acid anion
def: "Any anion formed by loss of a proton from a steroid acid." []
subset: 3:STAR
synonym: "steroid acid anions" RELATED [chebi]
is_a: CHEBI:29067 ! carboxylic acid anion
relationship: RO:0018033 CHEBI:47891 ! is deprotonated form of steroid acid
[Term]
id: CHEBI:50188
name: provitamin
def: "A substance that can be converted into a vitamin by animal tissues." []
subset: 3:STAR
synonym: "provitamins" RELATED [chebi]
xref: wikipedia.en:Provitamin {source="wikipedia.en"}
is_a: CHEBI:24432 ! biological role
[Term]
id: CHEBI:50267
name: protective agent
def: "Synthetic or natural substance which is given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent." []
subset: 3:STAR
synonym: "chemoprotectant" RELATED [chebi]
synonym: "chemoprotectants" RELATED [chebi]
synonym: "chemoprotective agent" RELATED [chebi]
synonym: "chemoprotective agents" RELATED [chebi]
synonym: "protective agents" RELATED [chebi]
is_a: CHEBI:23888 ! drug
[Term]
id: CHEBI:50297
name: canonical nucleotide residue
subset: 3:STAR
synonym: "canonical nucleotide residues" RELATED [chebi]
is_a: CHEBI:50319 ! nucleotide residue
[Term]
id: CHEBI:50298
name: canonical deoxyribonucleotide residue
subset: 3:STAR
synonym: "canonical deoxyribonucleotide residues" RELATED [chebi]
is_a: CHEBI:50297 ! canonical nucleotide residue
[Term]
id: CHEBI:50299
name: canonical ribonucleotide residue
subset: 3:STAR
synonym: "canonical ribonucleotide residues" RELATED [chebi]
is_a: CHEBI:50297 ! canonical nucleotide residue
[Term]
id: CHEBI:50312
name: onium compound
subset: 1:STAR
synonym: "onium compound" RELATED [chebi]
synonym: "onium compounds" EXACT IUPAC:NAME [IUPAC]
synonym: "onium compounds" RELATED IUPAC:NAME [chebi, iupac]
is_a: CHEBI:37577 ! heteroatomic molecular entity
[Term]
id: CHEBI:50313
name: onium cation
def: "Mononuclear cations derived by addition of a hydron to a mononuclear parent hydride of the pnictogen, chalcogen and halogen families." []
subset: 3:STAR
synonym: "onium cations" EXACT IUPAC:NAME [IUPAC]
synonym: "onium cations" RELATED IUPAC:NAME [chebi, iupac]
synonym: "onium ion" RELATED [chebi]
synonym: "onium ions" RELATED [chebi]
is_a: CHEBI:50312 ! onium compound
[Term]
id: CHEBI:50319
name: nucleotide residue
subset: 3:STAR
synonym: "nucleotide residues" RELATED [chebi]
is_a: CHEBI:33247 ! organic group
[Term]
id: CHEBI:50320
name: nucleoside residue
subset: 3:STAR
synonym: "nucleoside residues" RELATED [chebi]
is_a: CHEBI:33247 ! organic group
[Term]
id: CHEBI:50325
name: proteinogenic amino-acid side-chain group
def: "A univalent organyl group obtained by cleaving the bond from C-2 to the side chain of a proteinogenic amino-acid." []
subset: 3:STAR
synonym: "canonical amino-acid side-chain" RELATED [chebi]
synonym: "canonical amino-acid side-chains" RELATED [chebi]
synonym: "proteinogenic amino-acid side-chain" RELATED [chebi]
synonym: "proteinogenic amino-acid side-chain groups" RELATED [chebi]
synonym: "proteinogenic amino-acid side-chains" RELATED [chebi]
is_a: CHEBI:33249 ! organyl group
[Term]
id: CHEBI:50329
name: 2-carboxyethyl group
subset: 3:STAR
synonym: "2-carboxyethyl" EXACT IUPAC:NAME [IUPAC]
synonym: "2-carboxyethyl" RELATED IUPAC:NAME [iupac]
synonym: "glutamic acid side-chain" RELATED [chebi]
is_a: CHEBI:50325 ! proteinogenic amino-acid side-chain group
[Term]
id: CHEBI:50336
name: 4-hydroxybenzyl group
subset: 3:STAR
synonym: "4-hydroxybenzyl" EXACT IUPAC:NAME [IUPAC]
synonym: "4-hydroxybenzyl" RELATED IUPAC:NAME [iupac]
synonym: "tyrosine side-chain" RELATED [chebi]
is_a: CHEBI:50325 ! proteinogenic amino-acid side-chain group
[Term]
id: CHEBI:50402
name: androstanoid
def: "Any steroid based on an androstane skeleton and its derivatives." []
subset: 3:STAR
synonym: "androstanoids" RELATED [chebi]
is_a: CHEBI:35341 ! steroid
relationship: RO:0018040 CHEBI:35509 ! has parent hydride androstane
[Term]
id: CHEBI:50513
name: mydriatic agent
def: "Agent that dilates the pupil. Used in eye diseases and to facilitate eye examination. It may be either a sympathomimetic or parasympatholytic. The latter cause cycloplegia or paralysis of accommodation at high doses and may precipitate glaucoma." []
subset: 3:STAR
synonym: "mydriatics" RELATED [chebi]
is_a: CHEBI:23888 ! drug
[Term]
id: CHEBI:50514
name: vasoconstrictor agent
def: "Drug used to cause constriction of the blood vessels." []
subset: 3:STAR
is_a: CHEBI:35554 ! cardiovascular drug
[Term]
id: CHEBI:50646
name: bone density conservation agent
alt_id: CHEBI:72497
def: "An agent that inhibits bone resorption and/or favor bone mineralization and bone regeneration. Used to heal bone fractures and to treat bone diseases such as osteopenia and osteoporosis." []
subset: 3:STAR
synonym: "anti-osteopenia agent" RELATED [chebi]
synonym: "anti-osteopenia agents" RELATED [chebi]
synonym: "anti-osteopenia drug" RELATED [chebi]
synonym: "anti-osteopenia drugs" RELATED [chebi]
synonym: "anti-osteoporosis agent" RELATED [chebi]
synonym: "anti-osteoporosis agents" RELATED [chebi]
synonym: "anti-osteoporosis drug" RELATED [chebi]
synonym: "anti-osteoporosis drugs" RELATED [chebi]
synonym: "anti-osteoporotic" RELATED [chebi]
synonym: "anti-osteoporotic agent" RELATED [chebi]
synonym: "anti-osteoporotic agents" RELATED [chebi]
synonym: "anti-osteoporotic drug" RELATED [chebi]
synonym: "anti-osteoporotic drugs" RELATED [chebi]
synonym: "anti-osteoporotics" RELATED [chebi]
synonym: "antiosteoporotic" RELATED [chebi]
synonym: "antiosteoporotics" RELATED [chebi]
synonym: "bone density conservation agents" RELATED [chebi]
synonym: "bone density conservation drug" RELATED [chebi]
synonym: "bone density conservation drugs" RELATED [chebi]
xref: wikipedia.en:Osteoporosis {source="wikipedia.en"}
is_a: CHEBI:23888 ! drug
[Term]
id: CHEBI:50689
name: reproductive control drug
def: "A substance used either in the prevention or facilitation of pregnancy." []
subset: 3:STAR
synonym: "reproductive control agent" RELATED [chebi]
synonym: "reproductive control drugs" RELATED [chebi]
is_a: CHEBI:23888 ! drug
[Term]
id: CHEBI:50733
name: nutraceutical
def: "A product in capsule, tablet or liquid form that provide essential nutrients, such as a vitamin, an essential mineral, a protein, an herb, or similar nutritional substance." []
subset: 3:STAR
synonym: "Dietary Supplement" RELATED [chebi]
synonym: "Food Supplementation" RELATED [chebi]
synonym: "Nutritional supplement" RELATED [chebi]
is_a: CHEBI:23888 ! drug
[Term]
id: CHEBI:50745
name: progestogen
def: "A compound that interacts with progesterone receptors in target tissues to bring about effects similar to those of progesterone." []
subset: 3:STAR
synonym: "gestagen" RELATED [chebi]
synonym: "gestagens" RELATED [chebi]
synonym: "progestagen" RELATED [chebi]
synonym: "progestagens" RELATED [chebi]
synonym: "progestogens" RELATED [chebi]
is_a: CHEBI:50112 ! sex hormone
[Term]
id: CHEBI:50846
name: immunomodulator
def: "Biologically active substance whose activity affects or plays a role in the functioning of the immune system." []
subset: 3:STAR
synonym: "Biomodulator" RELATED [chebi]
synonym: "Immune factor" RELATED [chebi]
synonym: "Immunologic factor" RELATED [chebi]
synonym: "Immunological factor" RELATED [chebi]
synonym: "immunomodulators" RELATED [chebi]
xref: wikipedia.en:Immunotherapy {source="wikipedia.en"}
is_a: CHEBI:23888 ! drug
is_a: CHEBI:24432 ! biological role
[Term]
id: CHEBI:50847
name: immunological adjuvant
def: "A substance that augments, stimulates, activates, potentiates, or modulates the immune response at either the cellular or humoral level. A classical agent (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contains bacterial antigens. It could also be endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Its mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy is related to its antigen-specific immunoadjuvanticity." []
subset: 3:STAR
synonym: "Immunoactivator" RELATED [chebi]
synonym: "Immunoadjuvant" RELATED [chebi]
synonym: "Immunologic adjuvant" RELATED [chebi]
synonym: "Immunopotentiator" RELATED [chebi]
synonym: "Immunostimulant" RELATED [chebi]
xref: wikipedia.en:Immunologic_adjuvant {source="wikipedia.en"}
is_a: CHEBI:50846 ! immunomodulator
is_a: CHEBI:60809 ! adjuvant
[Term]
id: CHEBI:50858
name: corticosteroid
def: "A natural or synthetic analogue of the hormones secreted by the adrenal gland." []
subset: 3:STAR
synonym: "corticoides" RELATED [chebi]
synonym: "corticosteroides" RELATED [chebi]
synonym: "corticosteroids" RELATED [chebi]
is_a: CHEBI:35341 ! steroid
[Term]
id: CHEBI:50860
name: organic molecular entity
alt_id: CHEBI:25700
alt_id: CHEBI:33244
def: "Any molecular entity that contains carbon." []
subset: 3:STAR
synonym: "organic compounds" RELATED [chebi]
synonym: "organic entity" RELATED [chebi]
synonym: "organic molecular entities" RELATED [chebi]
is_a: CHEBI:33582 ! carbon group molecular entity
relationship: has_part CHEBI:27594 ! carbon atom
[Term]
id: CHEBI:50903
name: carcinogenic agent
def: "A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquistion of tumoral capabilities." []
subset: 3:STAR
synonym: "agente carcinogeno" RELATED [chebi]
synonym: "cancerigene" RELATED [chebi]
synonym: "cancerogene" RELATED [chebi]
synonym: "carcinogen" RELATED [chebi]
synonym: "carcinogene" RELATED [chebi]
synonym: "carcinogenic agents" RELATED [chebi]
synonym: "carcinogeno" RELATED [chebi]
synonym: "carcinogens" RELATED [chebi]
is_a: CHEBI:52209 ! aetiopathogenetic role
[Term]
id: CHEBI:50904
name: allergen
def: "A chemical compound, or part thereof, which causes the onset of an allergic reaction by interacting with any of the molecular pathways involved in an allergy." []
subset: 3:STAR
synonym: "alergeno" RELATED [chebi]
synonym: "allergene" RELATED [chebi]
synonym: "allergenic agent" RELATED [chebi]
xref: wikipedia.en:Allergen {source="wikipedia.en"}
is_a: CHEBI:52209 ! aetiopathogenetic role
[Term]
id: CHEBI:50906
name: role
def: "A role is particular behaviour which a material entity may exhibit." []
subset: 3:STAR
[Term]
id: CHEBI:50910
name: neurotoxin
alt_id: CHEBI:50911
def: "A poison that interferes with the functions of the nervous system." []
subset: 3:STAR
synonym: "agente neurotoxico" RELATED [chebi]
synonym: "nerve poison" RELATED [chebi]
synonym: "nerve poisons" RELATED [chebi]
synonym: "neurotoxic agent" RELATED [chebi]
synonym: "neurotoxic agents" RELATED [chebi]
synonym: "neurotoxicant" RELATED [chebi]
synonym: "neurotoxins" RELATED [chebi]
xref: wikipedia.en:Neurotoxin {source="wikipedia.en"}
is_a: CHEBI:52209 ! aetiopathogenetic role
is_a: CHEBI:64909 ! poison
[Term]
id: CHEBI:50967
name: non-covalently-bound molecular entity
def: "Systems consisting of two or more molecular entities held together by non-covalent interactions." []
subset: 3:STAR
synonym: "non-covalently-bound molecular entities" RELATED [chebi]
is_a: CHEBI:36357 ! polyatomic entity
[Term]
id: CHEBI:50994
name: primary amino compound
def: "A compound formally derived from ammonia by replacing one hydrogen atom by an organyl group." []
subset: 3:STAR
synonym: "primary amino compounds" RELATED [chebi]
is_a: CHEBI:50047 ! organic amino compound
relationship: RO:0018033 CHEBI:65296 ! is deprotonated form of primary ammonium ion
[Term]
id: CHEBI:51060
name: hormone agonist
def: "A chemical substance which binds to specific hormone receptors activating the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites." []
subset: 3:STAR
is_a: CHEBI:48705 ! agonist
is_a: CHEBI:51061 ! hormone receptor modulator
[Term]
id: CHEBI:51061
name: hormone receptor modulator
def: "A drug that modulates the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites." []
subset: 3:STAR
synonym: "hormone receptor modulators" RELATED [chebi]
is_a: CHEBI:90710 ! receptor modulator
[Term]
id: CHEBI:51086
name: chemical role
def: "A role played by the molecular entity or part thereof within a chemical context." []
subset: 3:STAR
is_a: CHEBI:50906 ! role
[Term]
id: CHEBI:51143
name: nitrogen molecular entity
alt_id: CHEBI:25556
alt_id: CHEBI:7594
subset: 3:STAR
synonym: "nitrogen compounds" RELATED [chebi]
synonym: "nitrogen molecular entities" RELATED [chebi]
synonym: "Nitrogenous compounds" RELATED [kegg.compound]
xref: kegg.compound:C06061 {source="kegg.compound"}
is_a: CHEBI:33302 ! pnictogen molecular entity
relationship: has_part CHEBI:25555 ! nitrogen atom
[Term]
id: CHEBI:51151
name: dipolar compound
def: "An organic molecule that is electrically neutral carrying a positive and a negative charge in one of its major canonical descriptions. In most dipolar compounds the charges are delocalized; however the term is also applied to species where this is not the case." []
subset: 3:STAR
synonym: "dipolar compounds" RELATED [chebi]
is_a: CHEBI:72695 ! organic molecule
[Term]
id: CHEBI:51422
name: organodiyl group
def: "Any organic substituent group, regardless of functional type, having two free valences at carbon atom(s)." []
subset: 3:STAR
synonym: "organodiyl groups" RELATED [chebi]
is_a: CHEBI:51446 ! organic divalent group
[Term]
id: CHEBI:51446
name: organic divalent group
subset: 1:STAR
is_a: CHEBI:33247 ! organic group
[Term]
id: CHEBI:51447
name: organic univalent group
subset: 1:STAR
synonym: "organic monovalent group" RELATED [chebi]
is_a: CHEBI:33247 ! organic group
[Term]
id: CHEBI:51689
name: enone
def: "An α,β-unsaturated ketone of general formula R1R2C=CR3‒C(=O)R4 (R4 ≠ H) in which the C=O function is conjugated to a C=C double bond at the α,β position." []
subset: 3:STAR
synonym: "enones" RELATED [chebi]
xref: wikipedia.en:Enone {source="wikipedia.en"}
is_a: CHEBI:51721 ! alpha,beta-unsaturated ketone
is_a: CHEBI:78840 ! olefinic compound
[Term]
id: CHEBI:51721
name: alpha,beta-unsaturated ketone
def: "A ketone of general formula R1R2C=CR3‒C(=O)R4 (R4 ≠ H) or R1C≡C‒C(=O)R2 (R2 ≠ H) in which the ketonic C=O function is conjugated to an unsaturated C-C bond at the α,β position." []
subset: 3:STAR
synonym: "alpha,beta-unsaturated ketones" RELATED [chebi]
is_a: CHEBI:17087 ! ketone
[Term]
id: CHEBI:51958
name: organic polycyclic compound
subset: 3:STAR
synonym: "organic polycyclic compounds" RELATED [chebi]
is_a: CHEBI:33635 ! polycyclic compound
is_a: CHEBI:33832 ! organic cyclic compound
[Term]
id: CHEBI:52206
name: biochemical role
def: "A biological role played by the molecular entity or part thereof within a biochemical context." []
subset: 3:STAR
is_a: CHEBI:24432 ! biological role
[Term]
id: CHEBI:52208
name: biophysical role
subset: 1:STAR
is_a: CHEBI:24432 ! biological role
[Term]
id: CHEBI:52209
name: aetiopathogenetic role
def: "A role played by the molecular entity or part thereof which causes the development of a pathological process." []
subset: 3:STAR
synonym: "etiopathogenetic agent" RELATED [chebi]
synonym: "etiopathogenetic role" RELATED [chebi]
is_a: CHEBI:24432 ! biological role
[Term]
id: CHEBI:52210
name: pharmacological role
def: "A biological role which describes how a drug interacts within a biological system and how the interactions affect its medicinal properties." []
subset: 3:STAR
is_a: CHEBI:24432 ! biological role
[Term]
id: CHEBI:52211
name: physiological role
def: "A biological role relating to the normal mechanisms and their interactions within a living system." []
subset: 1:STAR
is_a: CHEBI:24432 ! biological role
[Term]
id: CHEBI:52217
name: pharmaceutical
alt_id: CHEBI:33293
alt_id: CHEBI:33294
def: "Any substance introduced into a living organism with therapeutic or diagnostic purpose." []
subset: 3:STAR
synonym: "farmaco" RELATED [chebi]
synonym: "medicament" RELATED [chebi]
synonym: "pharmaceuticals" RELATED [chebi]
is_a: CHEBI:33232 ! application
[Term]
id: CHEBI:52254
name: apatite
def: "A phosphate mineral with the general formula Ca5(PO4)3X where X = OH, F or Cl." []
subset: 3:STAR
synonym: "hydroxyapatite" RELATED [chebi]
xref: hmdb:HMDB0033610 {source="hmdb"}
is_a: CHEBI:46723 ! phosphate mineral
[Term]
id: CHEBI:52255
name: hydroxylapatite
def: "A phosphate mineral with the formula Ca5(PO4)3(OH)." []
subset: 3:STAR
is_a: CHEBI:52254 ! apatite
[Term]
id: CHEBI:5254
name: galactolipid
def: "A glycolipid and which the glyco component is specified as galactosyl." []
subset: 3:STAR
is_a: CHEBI:33563 ! glycolipid
[Term]
id: CHEBI:52625
name: inorganic hydroxy compound
subset: 3:STAR
synonym: "inorganic hydroxides" RELATED [chebi]
is_a: CHEBI:24651 ! hydroxides
is_a: CHEBI:24835 ! inorganic molecular entity
[Term]
id: CHEBI:52845
name: cyclic organic group
def: "An organic group that consists of a closed ring. It may be a substituent or a skeleton." []
subset: 3:STAR
synonym: "cyclic organic groups" RELATED [chebi]
is_a: CHEBI:33247 ! organic group
[Term]
id: CHEBI:53000
name: epitope
def: "The biological role played by a material entity when bound by a receptor of the adaptive immune system. Specific site on an antigen to which an antibody binds." []
subset: 3:STAR
synonym: "antigenic determinant" RELATED [chebi]
synonym: "epitope function" RELATED [chebi]
synonym: "epitope role" RELATED [chebi]
is_a: CHEBI:24432 ! biological role
[Term]
id: CHEBI:53309
name: polyanionic macromolecule
def: "A polymer carrying multiple negative charges." []
subset: 3:STAR
synonym: "polyanion" RELATED [chebi]
synonym: "polyanions" RELATED [submitter]
is_a: CHEBI:53368 ! ionic macromolecule
[Term]
id: CHEBI:53368
name: ionic macromolecule
def: "A macromolecule containing ionic groups." []
subset: 3:STAR
synonym: "ionic polymer" RELATED [chebi]
synonym: "polyionic macromolecule" RELATED [chebi]
is_a: CHEBI:33839 ! macromolecule
[Term]
id: CHEBI:5391
name: glucagon
def: "A 29-amino acid peptide hormone consisting of His, Ser, Gln, Gly, Thr, Phe, Thr, Ser, Asp, Tyr, Ser, Lys, Tyr, Leu, Asp, Ser, Arg, Arg, Ala, Gln, Asp, Phe, Val, Gln, Trp, Leu, Met, Asn and Thr residues joined in sequence." []
subset: 3:STAR
synonym: "Glucagon" RELATED [kegg.compound]
synonym: "glucagon" RELATED http://purl.obolibrary.org/obo/chebi/INN [chemidplus]
synonym: "Glucagone" RELATED [chemidplus]
synonym: "glucagonum" RELATED http://purl.obolibrary.org/obo/chebi/INN [chemidplus]
synonym: "His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr" RELATED [chebi]
synonym: "His-ser-glu(nh2)-gly-thr-phe-thr-ser-asp-tyr-ser-lys-tyr-leu-asp-ser-arg-arg-ala-glu(NH2)-asp-phe-val-glu(NH2)-trp-leu-met-asp(NH2)-thr" RELATED [chemidplus]
synonym: "HSQGTFTSDYSKYLDSRRAQDFVQWLMNT" RELATED [chebi]
synonym: "L-histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-alpha-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-glutaminyl-L-alpha-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-L-threonine" EXACT IUPAC:NAME [IUPAC]
synonym: "L-histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-alpha-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-glutaminyl-L-alpha-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-L-threonine" RELATED IUPAC:NAME [iupac]
xref: cas:16941-32-5 {source="cas"}
xref: cas:9007-92-5 {source="cas"}
xref: drugbank:DB00040 {source="drugbank"}
xref: drugcentral:2994 {source="drugcentral"}
xref: kegg.compound:C01501 {source="kegg.compound"}
xref: kegg.drug:D00116 {source="kegg.drug"}
xref: pubmed:21940356 {source="pubmed"}
xref: pubmed:22014161 {source="pubmed"}
xref: pubmed:22154917 {source="pubmed"}
xref: pubmed:22166985 {source="pubmed"}
xref: pubmed:22167521 {source="pubmed"}
xref: pubmed:22214853 {source="pubmed"}
xref: pubmed:22227186 {source="pubmed"}
xref: pubmed:22286080 {source="pubmed"}
xref: pubmed:22294753 {source="pubmed"}
xref: pubmed:22318544 {source="pubmed"}
xref: pubmed:22334714 {source="pubmed"}
xref: pubmed:22399501 {source="pubmed"}
xref: pubmed:22438981 {source="pubmed"}
xref: pubmed:22454291 {source="pubmed"}
xref: reaxys:13191924 {source="reaxys"}
xref: wikipedia.en:Glucagon {source="wikipedia.en"}
is_a: CHEBI:25905 ! peptide hormone
[Term]
id: CHEBI:5686
name: heterocyclic compound
def: "A cyclic compound having as ring members atoms of at least two different elements." []
subset: 3:STAR
synonym: "compuesto heterociclico" RELATED [iupac]
synonym: "compuestos heterociclicos" RELATED [iupac]
synonym: "heterocycle" RELATED [chebi]
synonym: "Heterocyclic compound" RELATED [kegg.compound]
synonym: "heterocyclic compounds" RELATED [chebi]
is_a: CHEBI:33595 ! cyclic compound
[Term]
id: CHEBI:57299
name: ATP(3-)
def: "A ribonucleoside triphosphate oxoanion that is the trianion of adenosine 5'-triphosphate arising from deprotonation of three of the four free triphosphate OH groups." []
subset: 3:STAR
xref: beilstein:9535056 {source="beilstein"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:59724 ! ribonucleoside triphosphate oxoanion
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
relationship: RO:0018033 CHEBI:15422 ! is deprotonated form of ATP
relationship: RO:0018033 CHEBI:237958 ! is deprotonated form of ({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(9H-purin-9-yl)oxolan-2-yl]methyl phosphonato}oxy)(phosphonatooxy)phosphinate
relationship: RO:0018034 CHEBI:30616 ! is protonated form of ATP(4-)
[Term]
id: CHEBI:57652
name: chondroitin D-glucuronate anion
def: "Anionic form of chondroitin D-glucuronate arising from deprotonation of the carboxylic acid groups of the repeating units; major species at pH 7.3." []
subset: 3:STAR
synonym: "chondroitin D-glucuronate" RELATED [uniprot_ft]
synonym: "chondroitin D-glucuronate polyanion" RELATED [chebi]
is_a: CHEBI:61469 ! polyanionic polymer
relationship: RO:0018033 CHEBI:16137 ! is deprotonated form of chondroitin D-glucuronate
[Term]
id: CHEBI:57852
name: prephenate(2-)
def: "A dicarboxylic acid dianion that is the conjugate base of prephenic acid; major species at pH 7.3." []
subset: 3:STAR
synonym: "1-(2-carboxylato-2-oxoethyl)-4-hydroxycyclohexa-2,5-diene-1-carboxylate" EXACT IUPAC:NAME [IUPAC]
synonym: "1-(2-carboxylato-2-oxoethyl)-4-hydroxycyclohexa-2,5-diene-1-carboxylate" RELATED IUPAC:NAME [iupac]
synonym: "prephenate" RELATED [chebi]
synonym: "prephenate dianion" RELATED [chebi]
xref: beilstein:5288208 {source="beilstein"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:28965 ! dicarboxylic acid dianion
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0018033 CHEBI:16666 ! is deprotonated form of prephenic acid
[Term]
id: CHEBI:57867
name: nucleoside 5'-phosphate dianion
def: "The conjugate base of a nucleoside 5'-phosphate." []
subset: 3:STAR
synonym: "a nucleoside 5'-phosphate" RELATED [uniprot_ft]
synonym: "nucleoside 5'-phosphate dianions" RELATED [chebi]
is_a: CHEBI:58945 ! organophosphate oxoanion
relationship: RO:0018033 CHEBI:16701 ! is deprotonated form of nucleoside 5'-phosphate
[Term]
id: CHEBI:57887
name: tryptaminium
def: "An ammonium ion that is the conjugate acid of tryptamine arising from protonation of the primary amino group; major species at pH 7.3." []
subset: 3:STAR
synonym: "2-(1H-indol-3-yl)ethanaminium" EXACT IUPAC:NAME [IUPAC]
synonym: "2-(1H-indol-3-yl)ethanaminium" RELATED IUPAC:NAME [iupac]
synonym: "tryptamine" RELATED [uniprot_ft]
synonym: "tryptaminium cation" RELATED [chebi]
synonym: "tryptaminium(1+)" RELATED [chebi]
xref: gmelin:533978 {source="gmelin"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:65296 ! primary ammonium ion
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018034 CHEBI:16765 ! is protonated form of tryptamine
[Term]
id: CHEBI:57930
name: nucleoside 5'-diphosphate(3-)
def: "Trianion of nucleoside diphosphate arising from deprotonation of all three free OH groups of the diphosphate; major species at pH 7.3." []
subset: 3:STAR
synonym: "a ribonucleoside 5'-diphosphate" RELATED [uniprot_ft]
synonym: "NDP trianion" RELATED [chebi]
synonym: "NDP(3-)" RELATED [chebi]
synonym: "nucleoside diphosphate trianion" RELATED [chebi]
synonym: "ribonucleoside diphosphate trianion" RELATED [chebi]
synonym: "ribonucleoside diphosphate(3-)" RELATED [chebi]
is_a: CHEBI:58945 ! organophosphate oxoanion
relationship: RO:0018033 CHEBI:16862 ! is deprotonated form of nucleoside 5'-diphosphate
[Term]
id: CHEBI:57977
name: bilirubin(2-)
def: "A dicarboxylic acid dianion obtained by deprotonation of the two carboxy groups of bilirubin; major species at pH 7.3." []
subset: 3:STAR
synonym: "(4Z,15Z)-bilirubin IX-alpha" RELATED [uniprot_ft]
synonym: "2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoate" RELATED [chebi]
synonym: "bilirubin dianion" RELATED [chebi]
xref: beilstein:4083310 {source="beilstein"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:28965 ! dicarboxylic acid dianion
is_a: CHEBI:59252 ! linear tetrapyrrole anion
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018033 CHEBI:16990 ! is deprotonated form of bilirubin IXalpha
[Term]
id: CHEBI:57981
name: D-phenylalanine zwitterion
def: "A D-α-amino acid zwitterion that is D-phenylalanine in which a proton has been transferred from the carboxy group to the amino group. It is the major species at pH 7.3." []
subset: 3:STAR
synonym: "(2R)-2-ammonio-3-phenylpropanoate" RELATED [iupac]
synonym: "(2R)-2-azaniumyl-3-phenylpropanoate" EXACT IUPAC:NAME [IUPAC]
synonym: "(2R)-2-azaniumyl-3-phenylpropanoate" RELATED IUPAC:NAME [iupac]
synonym: "D-phenylalanine" RELATED [uniprot_ft]
xref: metacyc.compound:CPD-216 {source="metacyc.compound"}
is_a: CHEBI:59871 ! D-alpha-amino acid zwitterion
relationship: RO:0018036 CHEBI:16998 ! is tautomer of D-phenylalanine
relationship: RO:0018039 CHEBI:58095 ! is enantiomer of L-phenylalanine zwitterion
[Term]
id: CHEBI:58095
name: L-phenylalanine zwitterion
def: "An amino acid zwitterion arising from transfer of a proton from the carboxy to the amino group of L-phenylalanine; major species at pH 7.3." []
subset: 3:STAR
synonym: "(2S)-2-ammonio-3-phenylpropanoate" RELATED [iupac]
synonym: "(2S)-2-azaniumyl-3-phenylpropanoate" EXACT IUPAC:NAME [IUPAC]
synonym: "(2S)-2-azaniumyl-3-phenylpropanoate" RELATED IUPAC:NAME [iupac]
synonym: "L-phenylalanine" RELATED [uniprot_ft]
synonym: "phenylalanine" RELATED [chebi]
xref: metacyc.compound:PHE {source="metacyc.compound"}
xref: pubmed:21956539 {source="pubmed"}
is_a: CHEBI:35238 ! amino-acid zwitterion
relationship: RO:0018036 CHEBI:17295 ! is tautomer of L-phenylalanine
relationship: RO:0018039 CHEBI:57981 ! is enantiomer of D-phenylalanine zwitterion
[Term]
id: CHEBI:58104
name: nucleoside 5'-triphoshate(3-)
def: "Trianion of nucleoside triphosphate arising from deprotonation of three of the four free triphosphate OH groups." []
subset: 3:STAR
synonym: "NTP trianion" RELATED [chebi]
synonym: "NTP(3-)" RELATED [chebi]
synonym: "nucleoside triphosphate trianion" RELATED [chebi]
synonym: "ribonucleoside triphosphate trianion" RELATED [chebi]
synonym: "ribonucleoside triphosphate(3-)" RELATED [chebi]
is_a: CHEBI:59724 ! ribonucleoside triphosphate oxoanion
relationship: RO:0018033 CHEBI:17326 ! is deprotonated form of nucleoside 5'-triphoshate
relationship: RO:0018034 CHEBI:61557 ! is protonated form of nucleoside 5'-triphoshate(4-)
[Term]
id: CHEBI:58315
name: L-tyrosine zwitterion
def: "An amino acid zwitterion arising from transfer of a proton from the carboxy to the amino group of L-tyrosine; major species at pH 7.3." []
subset: 3:STAR
synonym: "(2S)-2-ammonio-3-(4-hydroxyphenyl)propanoate" RELATED [iupac]
synonym: "(2S)-2-azaniumyl-3-(4-hydroxyphenyl)propanoate" EXACT IUPAC:NAME [IUPAC]
synonym: "(2S)-2-azaniumyl-3-(4-hydroxyphenyl)propanoate" RELATED IUPAC:NAME [iupac]
synonym: "L-tyrosine" RELATED [uniprot_ft]
is_a: CHEBI:35238 ! amino-acid zwitterion
relationship: RO:0018033 CHEBI:32762 ! is deprotonated form of L-tyrosinium
relationship: RO:0018034 CHEBI:32760 ! is protonated form of L-tyrosinate(1-)
relationship: RO:0018036 CHEBI:17895 ! is tautomer of L-tyrosine
[Term]
id: CHEBI:58432
name: histaminium
def: "An ammonium ion that is the conjugate acid of histamine protonated on the side-chain nitrogen." []
subset: 3:STAR
synonym: "2-(1H-imidazol-4-yl)ethanaminium" EXACT IUPAC:NAME [IUPAC]
synonym: "2-(1H-imidazol-4-yl)ethanaminium" RELATED IUPAC:NAME [iupac]
synonym: "histamine" RELATED [uniprot_ft]
synonym: "histaminium cation" RELATED [chebi]
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018034 CHEBI:18295 ! is protonated form of histamine
[Term]
id: CHEBI:58570
name: D-tyrosine zwitterion
def: "A D-α-amino acid zwitterion that is D-tyrosine in which a proton has been transferred from the carboxy group to the amino group. It is the major species at pH 7.3." []
subset: 3:STAR
synonym: "(2R)-2-ammonio-3-(4-hydroxyphenyl)propanoate" EXACT IUPAC:NAME [IUPAC]
synonym: "(2R)-2-ammonio-3-(4-hydroxyphenyl)propanoate" RELATED IUPAC:NAME [iupac]
synonym: "D-tyrosine" RELATED [uniprot_ft]
xref: metacyc.compound:D-TYROSINE {source="metacyc.compound"}
is_a: CHEBI:59871 ! D-alpha-amino acid zwitterion
relationship: RO:0018036 CHEBI:28479 ! is tautomer of D-tyrosine
[Term]
id: CHEBI:58942
name: cationic amino-acid residue
def: "An amino-acid residue protonated on nitrogen." []
subset: 3:STAR
synonym: "amino acid cation residue" RELATED [chebi]
synonym: "amino acid cation residues" RELATED [chebi]
synonym: "amino-acid cation residue" RELATED [chebi]
synonym: "amino-acid cation residues" RELATED [chebi]
synonym: "cationic amino acid residue" RELATED [chebi]
synonym: "cationic amino acid residues" RELATED [chebi]
synonym: "cationic amino-acid residues" RELATED [chebi]
is_a: CHEBI:64769 ! organic cationic group
relationship: RO:0018034 CHEBI:33708 ! is protonated form of amino-acid residue
[Term]
id: CHEBI:58945
name: organophosphate oxoanion
def: "An organic phosphoric acid derivative in which one or more oxygen atoms of the phosphate group(s) has been deprotonated." []
subset: 3:STAR
synonym: "organophosphate oxoanions" RELATED [chebi]
is_a: CHEBI:25696 ! organic anion
is_a: CHEBI:26079 ! phosphoric acid derivative
[Term]
id: CHEBI:58951
name: short-chain fatty acid anion
def: "Any fatty acid anion obtained by removal of a proton from the carboxy group of a short-chain fatty acid (chain length of less than C6)." []
subset: 3:STAR
synonym: "a short-chain fatty acid" RELATED [uniprot_ft]
synonym: "short-chain fatty acid anions" RELATED [chebi]
is_a: CHEBI:28868 ! fatty acid anion
relationship: RO:0018033 CHEBI:26666 ! is deprotonated form of short-chain fatty acid
[Term]
id: CHEBI:58953
name: saturated fatty acid anion
def: "Any fatty acid anion in which there is no C‒C unsaturation." []
subset: 3:STAR
synonym: "saturated fatty acid anions" RELATED [chebi]
is_a: CHEBI:28868 ! fatty acid anion
[Term]
id: CHEBI:58954
name: straight-chain saturated fatty acid anion
def: "Any saturated fatty acid anion lacking a carbon side-chain." []
subset: 3:STAR
synonym: "straight-chain saturated fatty acid anions" RELATED [chebi]
is_a: CHEBI:58953 ! saturated fatty acid anion
relationship: RO:0018033 CHEBI:39418 ! is deprotonated form of straight-chain saturated fatty acid
[Term]
id: CHEBI:58958
name: organosulfate oxoanion
def: "An organic anion of general formula RS(=O)2O(−) where R is an organyl group." []
subset: 3:STAR
synonym: "organosulfate oxoanions" RELATED [chebi]
is_a: CHEBI:25696 ! organic anion
is_a: CHEBI:33482 ! sulfur oxoanion
relationship: RO:0018033 CHEBI:25704 ! is deprotonated form of organic sulfate
relationship: RO:0018038 CHEBI:16189 ! has functional parent sulfate
[Term]
id: CHEBI:59132
name: antigen
def: "Any substance that stimulates an immune response in the body, such as through antibody production or by presentation to a T-cell receptor after binding to a major histocompability complex (MHC)." []
subset: 3:STAR
synonym: "antigens" RELATED [chebi]
is_a: CHEBI:24432 ! biological role
[Term]
id: CHEBI:59202
name: straight-chain fatty acid
def: "Any fatty acid whose skeletal carbon atoms form an unbranched open chain." []
subset: 3:STAR
synonym: "straight-chain fatty acids" RELATED [chebi]
is_a: CHEBI:35366 ! fatty acid
relationship: RO:0018034 CHEBI:59203 ! is protonated form of straight-chain fatty acid anion
[Term]
id: CHEBI:59203
name: straight-chain fatty acid anion
def: "A fatty acid anion formed by deprotonation of the carboxylic acid functional group of a straight-chain fatty acid." []
subset: 3:STAR
synonym: "straight-chain FA anion" RELATED [chebi]
synonym: "straight-chain FA anions" RELATED [chebi]
synonym: "straight-chain fatty acid anions" RELATED [chebi]
is_a: CHEBI:28868 ! fatty acid anion
relationship: RO:0018033 CHEBI:59202 ! is deprotonated form of straight-chain fatty acid
[Term]
id: CHEBI:59252
name: linear tetrapyrrole anion
def: "An organic anion arising from deprotonation of a acyclic tetrapyrrole compound." []
subset: 3:STAR
synonym: "acyclic tetrapyrrole anion" RELATED [chebi]
synonym: "acyclic tetrapyrrole anions" RELATED [chebi]
synonym: "linear tetrapyrrole anions" RELATED [chebi]
is_a: CHEBI:25696 ! organic anion
[Term]
id: CHEBI:59698
name: phosphoric acids
def: "Compounds containing one or more phosphoric acid units." []
subset: 3:STAR
is_a: CHEBI:33457 ! phosphorus oxoacid
[Term]
id: CHEBI:59724
name: ribonucleoside triphosphate oxoanion
def: "An organophosphate anion resulting from deprotonation of at least one of the acidic hydroxy groups from the triphosphate moiety of a nucleoside triphosphate." []
subset: 3:STAR
synonym: "ribonucleoside triphosphate anion" RELATED [chebi]
synonym: "ribonucleoside triphosphate anions" RELATED [chebi]
synonym: "ribonucleoside triphosphate oxoanions" RELATED [chebi]
is_a: CHEBI:58945 ! organophosphate oxoanion
[Term]
id: CHEBI:59740
name: nucleophilic reagent
def: "A reagent that forms a bond to its reaction partner (the electrophile) by donating both bonding electrons." []
subset: 3:STAR
synonym: "nucleophile" RELATED [chebi]
synonym: "nucleophiles" RELATED [chebi]
synonym: "nucleophilic reagents" RELATED [chebi]
is_a: CHEBI:33893 ! reagent
is_a: CHEBI:39144 ! Lewis base
[Term]
id: CHEBI:59814
name: L-alpha-amino acid anion
def: "Conjugate base of an L-α-amino acid arising from deprotonation of the C-1 carboxy group." []
subset: 3:STAR
synonym: "L-alpha-amino carboxylate" RELATED [chebi]
is_a: CHEBI:33558 ! alpha-amino-acid anion
relationship: RO:0018033 CHEBI:15705 ! is deprotonated form of L-alpha-amino acid
[Term]
id: CHEBI:59826
name: progestin
def: "A synthetic progestogen." []
subset: 3:STAR
synonym: "progestins" RELATED [chebi]
xref: wikipedia.en:Progestin {source="wikipedia.en"}
is_a: CHEBI:50745 ! progestogen
[Term]
id: CHEBI:59869
name: L-alpha-amino acid zwitterion
def: "Zwitterionic form of an L-α-amino acid having an anionic carboxy group and a protonated amino group." []
subset: 3:STAR
synonym: "an L-alpha-amino acid" RELATED [uniprot_ft]
synonym: "L-alpha-amino acid zwitterions" RELATED [chebi]
is_a: CHEBI:78608 ! alpha-amino-acid zwitterion
relationship: RO:0018036 CHEBI:15705 ! is tautomer of L-alpha-amino acid
[Term]
id: CHEBI:59871
name: D-alpha-amino acid zwitterion
def: "Zwitterionic form of a D-α-amino acid having an anionic carboxy group and a protonated amino group." []
subset: 3:STAR
synonym: "a D-alpha-amino acid" RELATED [uniprot_ft]
synonym: "D-alpha-amino acid zwitterions" RELATED [chebi]
is_a: CHEBI:35238 ! amino-acid zwitterion
relationship: RO:0018036 CHEBI:16733 ! is tautomer of D-alpha-amino acid
[Term]
id: CHEBI:59888
name: gamma-aminobutyric acid zwitterion
def: "Zwitterionic form of γ-aminobutyric acid having an anionic carboxy group and a protonated amino group." []
subset: 3:STAR
synonym: "4-aminobutanoate" RELATED [uniprot_ft]
synonym: "4-ammoniobutanoate" RELATED [chebi]
synonym: "4-azaniumylbutanoate" EXACT IUPAC:NAME [IUPAC]
synonym: "4-azaniumylbutanoate" RELATED IUPAC:NAME [iupac]
xref: gmelin:1041559 {source="gmelin"}
is_a: CHEBI:35238 ! amino-acid zwitterion
relationship: RO:0018036 CHEBI:16865 ! is tautomer of gamma-aminobutyric acid
[Term]
id: CHEBI:59905
name: dopaminium(1+)
def: "An ammonium ion that is the conjugate acid of dopamine; major species at pH 7.3." []
subset: 3:STAR
synonym: "2-(3,4-dihydroxyphenyl)ethan-1-aminium" RELATED [chebi]
synonym: "2-(3,4-dihydroxyphenyl)ethanaminium" EXACT IUPAC:NAME [IUPAC]
synonym: "2-(3,4-dihydroxyphenyl)ethanaminium" RELATED IUPAC:NAME [iupac]
synonym: "dopamine" RELATED [uniprot_ft]
synonym: "dopaminium cation" RELATED [chebi]
xref: gmelin:328863 {source="gmelin"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018034 CHEBI:18243 ! is protonated form of dopamine
[Term]
id: CHEBI:59999
name: chemical substance
def: "A chemical substance is a portion of matter of constant composition, composed of molecular entities of the same type or of different types." []
subset: 3:STAR
synonym: "Chemische Substanz" RELATED [chebi]
is_a: CHEBI:24431 ! chemical entity
[Term]
id: CHEBI:60004
name: mixture
def: "A mixture is a chemical substance composed of multiple molecules, at least two of which are of a different kind." []
subset: 3:STAR
synonym: "Mischung" RELATED [chebi]
is_a: CHEBI:59999 ! chemical substance
[Term]
id: CHEBI:60027
name: polymer
def: "A polymer is a mixture, which is composed of macromolecules of different kinds and which may be differentiated by composition, length, degree of branching etc.." []
subset: 3:STAR
synonym: "Kunststoff" RELATED [chebi]
synonym: "Polymer" RELATED [chebi]
xref: wikipedia.en:Polymer {source="wikipedia.en"}
is_a: CHEBI:60004 ! mixture
relationship: has_part CHEBI:33839 ! macromolecule
[Term]
id: CHEBI:60164
name: ionic polymer
def: "An ionic polymer is a polymer, composed of ionic macromolecules." []
subset: 3:STAR
synonym: "polyionic polymer" RELATED [chebi]
is_a: CHEBI:60027 ! polymer
relationship: has_part CHEBI:53368 ! ionic macromolecule
[Term]
id: CHEBI:60240
name: divalent metal cation
def: "A metal cation with a valence of two." []
subset: 3:STAR
synonym: "a divalent metal cation" RELATED [uniprot_ft]
is_a: CHEBI:25213 ! metal cation
is_a: CHEBI:64641 ! divalent inorganic cation
[Term]
id: CHEBI:60242
name: monovalent inorganic cation
def: "An atom or small molecule with a positive charge that does not contain carbon in covalent linkage, with a valency of one." []
subset: 3:STAR
synonym: "a monovalent cation" RELATED [uniprot_ft]
is_a: CHEBI:36915 ! inorganic cation
[Term]
id: CHEBI:60466
name: peptide zwitterion
def: "Zwitterionic form of any peptide where, in general, the amino terminus is positively charged and the carboxy terminus is negatively charged." []
subset: 3:STAR
synonym: "a peptide" RELATED [uniprot_ft]
synonym: "peptide zwitterions" RELATED [chebi]
is_a: CHEBI:27369 ! zwitterion
relationship: RO:0018036 CHEBI:16670 ! is tautomer of peptide
[Term]
id: CHEBI:60809
name: adjuvant
def: "Any pharmacological or immunological agent that modifies the effect of other agents such as drugs or vaccines while having few if any direct effects when given by itself." []
subset: 3:STAR
synonym: "adjuvants" RELATED [chebi]
is_a: CHEBI:52217 ! pharmaceutical
[Term]
id: CHEBI:60816
name: immunogen
def: "An antigen capable, on its own, of inducing an immune response." []
subset: 3:STAR
xref: pubmed:19152635 {source="pubmed"}
xref: pubmed:19328011 {source="pubmed"}
xref: pubmed:19397283 {source="pubmed"}
is_a: CHEBI:59132 ! antigen
[Term]
id: CHEBI:60895
name: D-alpha-amino acid anion
def: "Any α-amino acid anion in which the parent amino acid has D-configuration." []
subset: 3:STAR
synonym: "D-alpha-amino acid anions" RELATED [chebi]
synonym: "D-alpha-amino carboxylate" RELATED [chebi]
is_a: CHEBI:33558 ! alpha-amino-acid anion
relationship: RO:0018033 CHEBI:16733 ! is deprotonated form of D-alpha-amino acid
[Term]
id: CHEBI:60924
name: keratan sulfate
def: "A sulfated glycosaminoglycan, a linear polymer that consists of the repeating disaccharide [3)-β-Gal-(1→4)-β-GlcNAc-(1→] and containing sulfo groups located at random positions." []
subset: 3:STAR
synonym: "keratan sulfates" RELATED [chebi]
is_a: CHEBI:35722 ! sulfated glycosaminoglycan
is_a: CHEBI:37395 ! mucopolysaccharide
relationship: RO:0018038 CHEBI:29057 ! has functional parent keratan
[Term]
id: CHEBI:60926
name: amino monosaccharide
def: "Any amino sugar that is a monosaccharide in which one alcoholic hydroxy group is replaced by an amino group." []
subset: 3:STAR
synonym: "amino monosaccharides" RELATED [chebi]
is_a: CHEBI:28963 ! amino sugar
[Term]
id: CHEBI:61115
name: EC 3.5.1.98 (histone deacetylase) inhibitor
def: "An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98)." []
subset: 3:STAR
synonym: "EC 3.5.1.98 (histone deacetylase) inhibitors" RELATED [chebi]
synonym: "EC 3.5.1.98 inhibitor" RELATED [chebi]
synonym: "EC 3.5.1.98 inhibitors" RELATED [chebi]
synonym: "HDAC inhibitor" RELATED [chebi]
synonym: "HDAC inhibitors" RELATED [chebi]
synonym: "HDACi" RELATED [chebi]
synonym: "HDACis" RELATED [chebi]
synonym: "HDI" RELATED [chebi]
synonym: "HDIs" RELATED [chebi]
synonym: "histone amidohydrolase inhibitor" RELATED [chebi]
synonym: "histone amidohydrolase inhibitors" RELATED [chebi]
synonym: "histone deacetylase (EC 3.5.1.98) inhibitor" RELATED [chebi]
synonym: "histone deacetylase (EC 3.5.1.98) inhibitors" RELATED [chebi]
synonym: "histone deacetylase inhibitor" RELATED [chebi]
synonym: "histone deacetylase inhibitors" RELATED [chebi]
xref: wikipedia.en:Histone_deacetylase_inhibitor {source="wikipedia.en"}
is_a: CHEBI:76807 ! EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor
[Term]
id: CHEBI:61120
name: nucleobase-containing molecular entity
def: "Any compound that has a nucleobase as a part." []
subset: 3:STAR
synonym: "nucleobase-containing compound" RELATED [submitter]
synonym: "nucleobase-containing compounds" RELATED [chebi]
synonym: "nucleobase-containing molecular entities" RELATED [chebi]
is_a: CHEBI:33833 ! heteroarene
is_a: CHEBI:51143 ! nitrogen molecular entity
relationship: RO:0018038 CHEBI:18282 ! has functional parent nucleobase
[Term]
id: CHEBI:61293
name: adenyl nucleotide
def: "A nucleotide having adenine as the base." []
subset: 3:STAR
is_a: CHEBI:26395 ! purine nucleotide
[Term]
id: CHEBI:61296
name: adenyl ribonucleotide
def: "A purine riboncleotide where adenine is the purine." []
subset: 3:STAR
synonym: "adenine ribonucleotide" RELATED [submitter]
is_a: CHEBI:26400 ! purine ribonucleotide
is_a: CHEBI:61293 ! adenyl nucleotide
[Term]
id: CHEBI:61313
name: C21-steroid
def: "A steroid that has a structure based on a 21-carbon (pregnane) skeleton. Note that individual examples may have ring substituents at other positions and/or contain double bonds, aromatic A-rings, expanded/contracted rings etc., so the formula and mass may vary from that given for the generic structure." []
subset: 3:STAR
synonym: "a C(21)-steroid" RELATED [uniprot_ft]
is_a: CHEBI:35341 ! steroid
[Term]
id: CHEBI:61469
name: polyanionic polymer
def: "A polymer, composed of polyanion macromolecules." []
subset: 3:STAR
synonym: "polyanion" RELATED [chebi]
synonym: "polyanions" RELATED [chebi]
is_a: CHEBI:60164 ! ionic polymer
relationship: has_part CHEBI:53309 ! polyanionic macromolecule
[Term]
id: CHEBI:61557
name: nucleoside 5'-triphoshate(4-)
def: "A ribonucleoside triphosphate oxoanion arising from global deprotonation of the triphosphate groups of any nucleoside triphosphate; major species at pH 7.3." []
subset: 3:STAR
synonym: "a ribonucleoside 5'-triphosphate" RELATED [uniprot_ft]
synonym: "NTP tetraanion" RELATED [chebi]
synonym: "NTP(4-)" RELATED [submitter]
synonym: "nucleoside 5'-triphosphate tetraanion" RELATED [chebi]
synonym: "nucleoside triphosphate(4-)" RELATED [chebi]
is_a: CHEBI:59724 ! ribonucleoside triphosphate oxoanion
relationship: RO:0018033 CHEBI:58104 ! is deprotonated form of nucleoside 5'-triphoshate(3-)
[Term]
id: CHEBI:61972
name: O(4)-phospho-L-tyrosine residue
def: "An α-amino-acid residue derived from O4-phospho-L-tyrosine." []
subset: 3:STAR
synonym: "O(4)-phosphotyrosine residue" RELATED [chebi]
synonym: "O-phospho-L-tyrosine residue" RELATED [chebi]
synonym: "O-phosphotyrosine residue" RELATED [chebi]
is_a: CHEBI:83228 ! L-alpha-amino acid residue
relationship: RO:0018034 CHEBI:61978 ! is protonated form of O(4)-phosphonato-L-tyrosine(2-) residue
relationship: RO:0018037 CHEBI:37788 ! is substitutent group from O(4)-phospho-L-tyrosine
[Term]
id: CHEBI:61978
name: O(4)-phosphonato-L-tyrosine(2-) residue
alt_id: CHEBI:82620
def: "An α-amino-acid residue anion obtained by deprotonation of the phosphate OH groups of O4-phospho-L-tyrosine residue; major speices at pH 7.3." []
subset: 3:STAR
synonym: "L-tyrosine-O-phosphate(2-) residue" RELATED [chebi]
synonym: "L-tyrosine-phosphate residue" RELATED [uniprot_ft]
is_a: CHEBI:35416 ! alpha-amino-acid residue anion
relationship: RO:0018033 CHEBI:61972 ! is deprotonated form of O(4)-phospho-L-tyrosine residue
relationship: RO:0018037 CHEBI:62338 ! is substitutent group from O(4)-phosphonato-L-tyrosine(2-)
relationship: RO:0018038 CHEBI:46858 ! has functional parent L-tyrosine residue
[Term]
id: CHEBI:62031
name: polar amino acid zwitterion
def: "Zwitterionic form of a polar amino acid having an anionic carboxy group and a protonated amino group." []
subset: 2:STAR
synonym: "a polar amino acid" RELATED [uniprot_ft]
xref: metacyc.compound:Polar-amino-acids {source="metacyc.compound"}
is_a: CHEBI:35238 ! amino-acid zwitterion
relationship: RO:0018036 CHEBI:26167 ! is tautomer of polar amino acid
[Term]
id: CHEBI:62338
name: O(4)-phosphonato-L-tyrosine(2-)
def: "An optically active form of O4-phosphonatotyrosine(2−) having L-configuration." []
subset: 3:STAR
synonym: "(2S)-2-ammonio-3-[4-(phosphonatooxy)phenyl]propanoate" RELATED [iupac]
synonym: "(2S)-2-azaniumyl-3-[4-(phosphonatooxy)phenyl]propanoate" EXACT IUPAC:NAME [IUPAC]
synonym: "(2S)-2-azaniumyl-3-[4-(phosphonatooxy)phenyl]propanoate" RELATED IUPAC:NAME [iupac]
synonym: "4-O-phospho-L-tyrosine" RELATED [uniprot_ft]
xref: metacyc.compound:CPD-3728 {source="metacyc.compound"}
xref: reaxys:10774475 {source="reaxys"}
is_a: CHEBI:74955 ! O(4)-phosphonatotyrosine(2-)
relationship: RO:0018033 CHEBI:37788 ! is deprotonated form of O(4)-phospho-L-tyrosine
relationship: RO:0018039 CHEBI:74656 ! is enantiomer of O(4)-phosphonato-D-tyrosine(2-)
[Term]
id: CHEBI:62488
name: signalling molecule
def: "A molecular messenger in which the molecule is specifically involved in transmitting information between cells. Such molecules are released from the cell sending the signal, cross over the gap between cells by diffusion, and interact with specific receptors in another cell, triggering a response in that cell by activating a series of enzyme controlled reactions which lead to changes inside the cell." []
subset: 3:STAR
synonym: "signal molecule" RELATED [chebi]
synonym: "signal molecules" RELATED [chebi]
synonym: "signaling molecule" RELATED [chebi]
synonym: "signaling molecules" RELATED [chebi]
synonym: "signalling molecules" RELATED [chebi]
is_a: CHEBI:33280 ! molecular messenger
[Term]
id: CHEBI:62643
name: anionic phospholipid
def: "Any organophosphate oxoanion that is a negatively charged phospholipid, e.g. phosphatidylserine(1−), phosphatidate(2−), phosphatidylglycerol(1−)." []
subset: 3:STAR
synonym: "anionic phospholipids" RELATED [chebi]
synonym: "phospholipid anion" RELATED [chebi]
synonym: "phospholipid anions" RELATED [chebi]
is_a: CHEBI:58945 ! organophosphate oxoanion
relationship: RO:0018033 CHEBI:16247 ! is deprotonated form of phospholipid
[Term]
id: CHEBI:62761
name: tyrosine derivative
def: "An amino acid derivative resulting from reaction of tyrosine at the amino group or the carboxy group, any substitution of phenyl hydrogens, or from the replacement of any hydrogen of tyrosine by a heteroatom. The definition normally excludes peptides containing tyrosine residues." []
subset: 3:STAR
synonym: "tyrosine derivatives" RELATED [chebi]
is_a: CHEBI:25985 ! phenylalanine derivative
relationship: RO:0018038 CHEBI:18186 ! has functional parent tyrosine
[Term]
id: CHEBI:62803
name: fuel additive
def: "Any additive that enhances the efficiency of fuel." []
subset: 3:STAR
synonym: "fuel additives" RELATED [chebi]
synonym: "fuel enhancer" RELATED [chebi]
is_a: CHEBI:51086 ! chemical role
[Term]
id: CHEBI:62941
name: glycosylceramide
def: "A ceramide compound formed by the replacement of the glycosidic hydroxy group of a cyclic form of a monosaccharide (or derivative) by a ceramide group." []
subset: 3:STAR
synonym: "glycosylceramides" RELATED [chebi]
is_a: CHEBI:17761 ! ceramide
is_a: CHEBI:24402 ! glycosphingolipid
[Term]
id: CHEBI:63161
name: glycosyl compound
def: "A carbohydrate derivative arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to an oxygen, carbon, nitrogen or sulfur atom of a separate entity." []
subset: 3:STAR
synonym: "glycosyl compounds" RELATED [chebi]
is_a: CHEBI:63299 ! carbohydrate derivative
[Term]
id: CHEBI:63248
name: oxidising agent
def: "A substance that removes electrons from another reactant in a redox reaction." []
subset: 3:STAR
synonym: "oxidant" RELATED [chebi]
synonym: "oxidants" RELATED [chebi]
synonym: "oxidiser" RELATED [chebi]
synonym: "oxidisers" RELATED [chebi]
synonym: "oxidising agents" RELATED [chebi]
synonym: "oxidizer" RELATED [chebi]
synonym: "oxidizers" RELATED [chebi]
synonym: "oxidizing agent" RELATED [chebi]
synonym: "oxidizing agents" RELATED [chebi]
is_a: CHEBI:51086 ! chemical role
[Term]
id: CHEBI:63299
name: carbohydrate derivative
def: "Any organooxygen compound derived from a carbohydrate by replacement of one or more hydroxy group(s) by an amino group, a thiol group or similar heteroatomic groups. The term also includes derivatives of these compounds." []
subset: 3:STAR
synonym: "carbohydrate derivatives" RELATED [chebi]
synonym: "derivatised carbohydrate" RELATED [chebi]
synonym: "derivatised carbohydrates" RELATED [chebi]
synonym: "derivatized carbohydrate" RELATED [chebi]
synonym: "derivatized carbohydrates" RELATED [chebi]
is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives
relationship: RO:0018038 CHEBI:16646 ! has functional parent carbohydrate
[Term]
id: CHEBI:63332
name: EC 3.1.3.1 (alkaline phosphatase) inhibitor
def: "An EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor that interferes with the action of alkaline phosphatase (EC 3.1.3.1)." []
subset: 3:STAR
synonym: "alkaline phenyl phosphatase inhibitor" RELATED [chebi]
synonym: "alkaline phenyl phosphatase inhibitors" RELATED [chebi]
synonym: "alkaline phosphatase (EC 3.1.3.1) inhibitor" RELATED [chebi]
synonym: "alkaline phosphatase (EC 3.1.3.1) inhibitors" RELATED [chebi]
synonym: "alkaline phosphatase inhibitor" RELATED [chebi]
synonym: "alkaline phosphatase inhibitors" RELATED [chebi]
synonym: "alkaline phosphohydrolase inhibitor" RELATED [chebi]
synonym: "alkaline phosphohydrolase inhibitors" RELATED [chebi]
synonym: "alkaline phosphomonoesterase inhibitor" RELATED [chebi]
synonym: "alkaline phosphomonoesterase inhibitors" RELATED [chebi]
synonym: "EC 3.1.3.1 (alkaline phosphatase) inhibitors" RELATED [chebi]
synonym: "EC 3.1.3.1 inhibitor" RELATED [chebi]
synonym: "EC 3.1.3.1 inhibitors" RELATED [chebi]
synonym: "glycerophosphatase inhibitor" RELATED [chebi]
synonym: "glycerophosphatase inhibitors" RELATED [chebi]
synonym: "orthophosphoric-monoester phosphohydrolase (alkaline optimum) inhibitor" RELATED [chebi]
synonym: "orthophosphoric-monoester phosphohydrolase (alkaline optimum) inhibitors" RELATED [chebi]
synonym: "phosphate-monoester phosphohydrolase (alkaline optimum) inhibitor" RELATED [chebi]
synonym: "phosphate-monoester phosphohydrolase (alkaline optimum) inhibitors" RELATED [chebi]
synonym: "phosphomonoesterase inhibitor" RELATED [chebi]
synonym: "phosphomonoesterase inhibitors" RELATED [chebi]
xref: wikipedia.en:Alkaline_phosphatase {source="wikipedia.en"}
is_a: CHEBI:76775 ! EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor
[Term]
id: CHEBI:63367
name: monosaccharide derivative
def: "A carbohydrate derivative that is formally obtained from a monosaccharide." []
subset: 3:STAR
synonym: "monosaccharide derivatives" RELATED [chebi]
is_a: CHEBI:63299 ! carbohydrate derivative
relationship: RO:0018038 CHEBI:35381 ! has functional parent monosaccharide
[Term]
id: CHEBI:63409
name: pentose derivative
def: "A monosaccharide derivative that is formally obtained from a pentose." []
subset: 3:STAR
synonym: "pentose derivatives" RELATED [chebi]
is_a: CHEBI:63367 ! monosaccharide derivative
relationship: RO:0018038 CHEBI:25901 ! has functional parent pentose
[Term]
id: CHEBI:63436
name: carbohydrate acid derivative
def: "A carbohydrate derivative that is formally obtained from a carbohydrate acid." []
subset: 3:STAR
synonym: "carbohydrate acid derivatives" RELATED [chebi]
is_a: CHEBI:63299 ! carbohydrate derivative
relationship: RO:0018034 CHEBI:63551 ! is protonated form of carbohydrate acid derivative anion
relationship: RO:0018038 CHEBI:33720 ! has functional parent carbohydrate acid
[Term]
id: CHEBI:63473
name: aromatic amino-acid anion
def: "An aromatic amino acid whose α-carboxylic acid group is ionized (non-protonated)." []
subset: 3:STAR
synonym: "aromatic amino-acid anions" RELATED [chebi]
is_a: CHEBI:37022 ! amino-acid anion
relationship: RO:0018033 CHEBI:33856 ! is deprotonated form of aromatic amino acid
[Term]
id: CHEBI:63534
name: monoamine
def: "An aralylamino compound which contains one amino group connected to an aromatic ring by a two-carbon chain. Monoamines are derived from aromatic amino acids like phenylalanine, tyrosine, tryptophan, and the thyroid hormones by the action of aromatic amino acid decarboxylase enzymes." []
subset: 3:STAR
synonym: "monoamines" RELATED [chebi]
synonym: "naturally occurring monoamine" RELATED [chebi]
synonym: "naturally occurring monoamines" RELATED [chebi]
xref: pubmed:21822758 {source="pubmed"}
xref: pubmed:21993877 {source="pubmed"}
xref: pubmed:22005599 {source="pubmed"}
xref: pubmed:22082101 {source="pubmed"}
xref: pubmed:22153577 {source="pubmed"}
xref: pubmed:22213370 {source="pubmed"}
xref: pubmed:22218931 {source="pubmed"}
xref: pubmed:22342987 {source="pubmed"}
xref: pubmed:22371656 {source="pubmed"}
is_a: CHEBI:64365 ! aralkylamino compound
[Term]
id: CHEBI:63551
name: carbohydrate acid derivative anion
def: "A carboxylic acid anion resulting from the deprotonation of the carboxy group of a carbohydrate acid derivative." []
subset: 3:STAR
synonym: "carbohydrate acid anion derivative" RELATED [chebi]
synonym: "carbohydrate acid anion derivatives" RELATED [chebi]
synonym: "carbohydrate acid derivative anions" RELATED [chebi]
is_a: CHEBI:29067 ! carboxylic acid anion
relationship: RO:0018033 CHEBI:63436 ! is deprotonated form of carbohydrate acid derivative
relationship: RO:0018038 CHEBI:33721 ! has functional parent carbohydrate acid anion
[Term]
id: CHEBI:64047
name: food additive
def: "Any substance which is added to food to preserve or enhance its flavour and/or appearance." []
subset: 3:STAR
synonym: "food additives" RELATED [chebi]
xref: wikipedia.en:Food_additive {source="wikipedia.en"}
is_a: CHEBI:33232 ! application
is_a: CHEBI:78295 ! food component
[Term]
id: CHEBI:64049
name: food acidity regulator
def: "A food additive that is used to change or otherwise control the acidity or alkalinity of foods. They may be acids, bases, neutralising agents or buffering agents." []
subset: 3:STAR
synonym: "acidity regulator" RELATED [chebi]
synonym: "acidity regulators" RELATED [chebi]
synonym: "food acidity regulators" RELATED [chebi]
synonym: "pH control agent" RELATED [chebi]
synonym: "pH control agents" RELATED [chebi]
xref: wikipedia.en:Acidity_regulator {source="wikipedia.en"}
is_a: CHEBI:64047 ! food additive
[Term]
id: CHEBI:64365
name: aralkylamino compound
def: "An organic amino compound in which an aminoalkyl group is linked to an arene." []
subset: 3:STAR
synonym: "aralkylamino compounds" RELATED [chebi]
is_a: CHEBI:50047 ! organic amino compound
[Term]
id: CHEBI:64416
name: EC 1.3.1.43 (arogenate dehydrogenase) inhibitor
def: "An EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of arogenate dehydrogenase (EC 1.3.1.43)." []
subset: 3:STAR
synonym: "arogenate dehydrogenase (EC 1.3.1.43) inhibitor" RELATED [chebi]
synonym: "arogenate dehydrogenase (EC 1.3.1.43) inhibitors" RELATED [chebi]
synonym: "arogenate dehydrogenase inhibitor" RELATED [chebi]
synonym: "arogenate dehydrogenase inhibitors" RELATED [chebi]
synonym: "cyclohexadienyl dehydrogenase inhibitor" RELATED [chebi]
synonym: "cyclohexadienyl dehydrogenase inhibitors" RELATED [chebi]
synonym: "EC 1.3.1.43 (arogenate dehydrogenase) inhibitors" RELATED [chebi]
synonym: "EC 1.3.1.43 inhibitor" RELATED [chebi]
synonym: "EC 1.3.1.43 inhibitors" RELATED [chebi]
synonym: "L-arogenate:NAD(+) oxidoreductase (decarboxylating) inhibitor" RELATED [chebi]
synonym: "L-arogenate:NAD(+) oxidoreductase (decarboxylating) inhibitors" RELATED [chebi]
synonym: "L-arogenate:NAD+ oxidoreductase (decarboxylating) inhibitor" RELATED [chebi]
synonym: "L-arogenate:NAD+ oxidoreductase (decarboxylating) inhibitors" RELATED [chebi]
synonym: "L-arogenate:NAD+ oxidoreductase inhibitor" RELATED [chebi]
synonym: "L-arogenate:NAD+ oxidoreductase inhibitors" RELATED [chebi]
synonym: "TyrA(a) inhibitor" RELATED [chebi]
synonym: "TyrA(a) inhibitors" RELATED [chebi]
xref: wikipedia.en:Arogenate_dehydrogenase {source="wikipedia.en"}
is_a: CHEBI:76857 ! EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor
[Term]
id: CHEBI:64583
name: sphingomyelin
def: "Any of a class of phospholipids in which the amino group of a sphingoid base is in amide linkage with one of several fatty acids, while the terminal hydroxy group of the sphingoid base is esterified to phosphorylcholine." []
subset: 3:STAR
synonym: "an N-(acyl)-sphingosylphosphocholine" RELATED [uniprot_ft]
synonym: "Ceramide phosphocholine" RELATED [lipidmaps]
xref: lipidmaps_class:LMSP0301 {source="lipidmaps_class"}
xref: pubmed:27242221 {source="pubmed"}
is_a: CHEBI:140325 ! secondary carboxamide
is_a: CHEBI:35284 ! ammonium betaine
is_a: CHEBI:35786 ! phosphosphingolipid
is_a: CHEBI:36700 ! phosphocholines
[Term]
id: CHEBI:64600
name: C21-steroid hormone
def: "A steroid compound with a structure based on a 21-carbon (pregnane) skeleton that acts as a hormone." []
subset: 3:STAR
synonym: "C21-steroid hormones" RELATED [chebi]
is_a: CHEBI:26764 ! steroid hormone
is_a: CHEBI:61313 ! C21-steroid
[Term]
id: CHEBI:64628
name: somatostatin
def: "A fourteen-membered heterodetic cyclic peptide comprising the sequence Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys cyclised by a disulfide bridge between the two Cys residues at positions 3 and 14." []
subset: 3:STAR
synonym: "Ala-Gly-cyclo-[Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys]" RELATED [chebi]
synonym: "L-alanyl-N-[(4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-19,34-bis(4-aminobutyl)-31-(2-amino-2-oxoethyl)-13,25,28-tribenzyl-4-carboxy-10,16-bis[(1R)-1-hydroxyethyl]-7-(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriacontan-37-yl]glycinamide" EXACT IUPAC:NAME [IUPAC]
synonym: "L-alanyl-N-[(4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-19,34-bis(4-aminobutyl)-31-(2-amino-2-oxoethyl)-13,25,28-tribenzyl-4-carboxy-10,16-bis[(1R)-1-hydroxyethyl]-7-(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriacontan-37-yl]glycinamide" RELATED IUPAC:NAME [iupac]
synonym: "L-alanylglycyl-L-cysteinyl-L-lysyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-cysteine cyclic (3-14) disulfide" RELATED [chemidplus]
synonym: "somatostatin" RELATED http://purl.obolibrary.org/obo/chebi/INN [kegg.drug]
synonym: "Somatostatin-1" RELATED [kegg.compound]
synonym: "Somatostatin-14" RELATED [kegg.compound]
synonym: "somatostatina" RELATED http://purl.obolibrary.org/obo/chebi/INN [chemidplus]
synonym: "somatostatine" RELATED http://purl.obolibrary.org/obo/chebi/INN [chemidplus]
synonym: "somatostatinum" RELATED http://purl.obolibrary.org/obo/chebi/INN [chemidplus]
synonym: "Synthetic growth hormone release-inhibiting hormone" RELATED [chemidplus]
xref: cas:38916-34-6 {source="cas"}
xref: drugcentral:2997 {source="drugcentral"}
xref: hmdb:HMDB0013072 {source="hmdb"}
xref: kegg.compound:C16022 {source="kegg.compound"}
xref: kegg.drug:D07431 {source="kegg.drug"}
xref: lincs.smallmolecule:LSM-5326 {source="lincs.smallmolecule"}
xref: pubmed:21922516 {source="pubmed"}
xref: pubmed:22129035 {source="pubmed"}
xref: pubmed:22147011 {source="pubmed"}
xref: pubmed:22251942 {source="pubmed"}
xref: pubmed:22483686 {source="pubmed"}
xref: pubmed:22509294 {source="pubmed"}
xref: reaxys:10148626 {source="reaxys"}
xref: wikipedia.en:Somatostatin {source="wikipedia.en"}
is_a: CHEBI:24533 ! heterodetic cyclic peptide
is_a: CHEBI:25905 ! peptide hormone
[Term]
id: CHEBI:64641
name: divalent inorganic cation
def: "An inorganic cation with a valency of two." []
subset: 3:STAR
is_a: CHEBI:36915 ! inorganic cation
[Term]
id: CHEBI:64708
name: one-carbon compound
def: "An organic molecular entity containing a single carbon atom (C1)." []
subset: 3:STAR
synonym: "one-carbon compounds" RELATED [chebi]
is_a: CHEBI:50860 ! organic molecular entity
[Term]
id: CHEBI:64709
name: organic acid
def: "Any organic molecular entity that is acidic and contains carbon in covalent linkage." []
subset: 3:STAR
synonym: "organic acids" RELATED [chebi]
is_a: CHEBI:50860 ! organic molecular entity
[Term]
id: CHEBI:64766
name: cationic group
def: "A group that carries an overall positive charge." []
subset: 3:STAR
synonym: "cationic groups" RELATED [chebi]
is_a: CHEBI:24433 ! group
[Term]
id: CHEBI:64767
name: anionic group
def: "A group that carries an overall negative charge." []
subset: 3:STAR
synonym: "anionic groups" RELATED [chebi]
is_a: CHEBI:24433 ! group
[Term]
id: CHEBI:64769
name: organic cationic group
def: "A cationic group that contains carbon." []
subset: 3:STAR
synonym: "organic cationic groups" RELATED [chebi]
is_a: CHEBI:64766 ! cationic group
relationship: RO:0018034 CHEBI:33247 ! is protonated form of organic group
[Term]
id: CHEBI:64775
name: organic anionic group
def: "An anionic group that contains carbon." []
subset: 3:STAR
synonym: "organic anionic groups" RELATED [chebi]
is_a: CHEBI:64767 ! anionic group
relationship: RO:0018033 CHEBI:33247 ! is deprotonated form of organic group
[Term]
id: CHEBI:64898
name: anionic amino-acid residue
def: "An amino-acid residue carrying an overall negative charge." []
subset: 3:STAR
synonym: "amino acid anion residue" RELATED [chebi]
synonym: "amino acid anion residues" RELATED [chebi]
synonym: "amino-acid anion residue" RELATED [chebi]
synonym: "amino-acid anion residues" RELATED [chebi]
synonym: "anionic amino acid residue" RELATED [chebi]
synonym: "anionic amino acid residues" RELATED [chebi]
is_a: CHEBI:64775 ! organic anionic group
relationship: RO:0018033 CHEBI:33708 ! is deprotonated form of amino-acid residue
[Term]
id: CHEBI:64909
name: poison
def: "Any substance that causes disturbance to organisms by chemical reaction or other activity on the molecular scale, when a sufficient quantity is absorbed by the organism." []
subset: 3:STAR
synonym: "poisonous agent" RELATED [chebi]
synonym: "poisonous agents" RELATED [chebi]
synonym: "poisonous substance" RELATED [chebi]
synonym: "poisonous substances" RELATED [chebi]
synonym: "poisons" RELATED [chebi]
synonym: "toxic agent" RELATED [chebi]
synonym: "toxic agents" RELATED [chebi]
synonym: "toxic substance" RELATED [chebi]
synonym: "toxic substances" RELATED [chebi]
xref: wikipedia.en:Poison {source="wikipedia.en"}
is_a: CHEBI:24432 ! biological role
[Term]
id: CHEBI:6495
name: lipoprotein
def: "A clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids." []
subset: 3:STAR
synonym: "Lipoprotein" RELATED [kegg.compound]
synonym: "lipoprotein particle" RELATED [chebi]
synonym: "lipoproteins" EXACT IUPAC:NAME [IUPAC]
synonym: "lipoproteins" RELATED IUPAC:NAME [iupac]
xref: kegg.compound:C01834 {source="kegg.compound"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:33837 ! conjugated protein
is_a: CHEBI:39024 ! clathrate compound
relationship: has_part CHEBI:39015 ! apolipoprotein
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
[Term]
id: CHEBI:65212
name: polysaccharide derivative
def: "A carbohydrate derivative that is any derivative of a polysaccharide." []
subset: 3:STAR
synonym: "polysaccharide derivatives" RELATED [chebi]
is_a: CHEBI:167559 ! glycan
is_a: CHEBI:33694 ! biomacromolecule
is_a: CHEBI:63299 ! carbohydrate derivative
relationship: RO:0018038 CHEBI:18154 ! has functional parent polysaccharide
[Term]
id: CHEBI:65255
name: food preservative
def: "Substances which are added to food in order to prevent decomposition caused by microbial growth or by undesirable chemical changes." []
subset: 3:STAR
synonym: "food preservatives" RELATED [chebi]
is_a: CHEBI:64047 ! food additive
[Term]
id: CHEBI:65256
name: antimicrobial food preservative
def: "A food preservative which prevents decomposition of food by preventing the growth of fungi or bacteria. In European countries, E-numbers for permitted food preservatives are from E200 to E299, divided into sorbates (E200-209), benzoates (E210-219), sulfites (E220-229), phenols and formates (E230-239), nitrates (E240-259), acetates (E260-269), lactates (E270-279), propionates (E280-289) and others (E290-299)." []
subset: 3:STAR
synonym: "antimicrobial food preservatives" RELATED [chebi]
synonym: "antimicrobial preservative" RELATED [chebi]
synonym: "antimicrobial preservatives" RELATED [chebi]
is_a: CHEBI:33281 ! antimicrobial agent
is_a: CHEBI:65255 ! food preservative
[Term]
id: CHEBI:65265
name: antacid
def: "Any substance which is used to neutralise stomach acidity." []
subset: 3:STAR
synonym: "antacids" RELATED [chebi]
xref: wikipedia.en:Antacid {source="wikipedia.en"}
is_a: CHEBI:23888 ! drug
is_a: CHEBI:52210 ! pharmacological role
[Term]
id: CHEBI:65296
name: primary ammonium ion
def: "An ammonium ion derivative resulting from the protonation of the nitrogen atom of a primary amino compound. Major species at pH 7.3." []
subset: 3:STAR
synonym: "a primary amine" RELATED [uniprot_ft]
synonym: "substituted ammonium" RELATED [chebi]
is_a: CHEBI:25697 ! organic cation
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: RO:0018034 CHEBI:50994 ! is protonated form of primary amino compound
[Term]
id: CHEBI:67079
name: anti-inflammatory agent
def: "Any compound that has anti-inflammatory effects." []
subset: 3:STAR
synonym: "anti-inflammatory agents" RELATED [chebi]
synonym: "antiinflammatory agent" RELATED [chebi]
synonym: "antiinflammatory agents" RELATED [chebi]
is_a: CHEBI:33232 ! application
[Term]
id: CHEBI:67200
name: provitamin A
def: "A provitamin that can be converted into vitamin A by enzymes from animal tissues." []
subset: 3:STAR
synonym: "provitamin As" RELATED [chebi]
is_a: CHEBI:50188 ! provitamin
[Term]
id: CHEBI:68452
name: azole
def: "Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen." []
subset: 3:STAR
synonym: "azoles" RELATED [chebi]
xref: wikipedia.en:Azole {source="wikipedia.en"}
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound
is_a: CHEBI:38179 ! monocyclic heteroarene
[Term]
id: CHEBI:70709
name: progesterone receptor agonist
def: "A hormone agonist that binds to and activates progesterone receptors." []
subset: 3:STAR
synonym: "PR agonist" RELATED [chebi]
synonym: "PR agonists" RELATED [chebi]
synonym: "progesterone receptor agonists" RELATED [chebi]
is_a: CHEBI:51060 ! hormone agonist
[Term]
id: CHEBI:71406
name: (R)-adrenaline(1+)
def: "An organic cation that is the conjugate acid of (R)-adrenaline, obtained by protonation of the amino group; major species at pH 7.3." []
subset: 3:STAR
synonym: "(2R)-2-(3,4-dihydroxyphenyl)-2-hydroxy-N-methylethanaminium" EXACT IUPAC:NAME [IUPAC]
synonym: "(2R)-2-(3,4-dihydroxyphenyl)-2-hydroxy-N-methylethanaminium" RELATED IUPAC:NAME [iupac]
synonym: "(R)-adrenaline" RELATED [uniprot_ft]
synonym: "(R)-adrenaline cation" RELATED [chebi]
synonym: "L-epinephrine cation" RELATED [chebi]
synonym: "L-epinephrine(1+)" RELATED [chebi]
xref: metacyc.compound:L-EPINEPHRINE {source="metacyc.compound"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:25697 ! organic cation
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018034 CHEBI:28918 ! is protonated form of (R)-adrenaline
[Term]
id: CHEBI:71666
name: gamma-amino acid anion
def: "An amino-acid anion in which the amino group is situated γ- to the carboxylate group." []
subset: 3:STAR
synonym: "gamma-amino acid anions" RELATED [chebi]
is_a: CHEBI:37022 ! amino-acid anion
relationship: RO:0018033 CHEBI:33707 ! is deprotonated form of gamma-amino acid
[Term]
id: CHEBI:72587
name: (R)-noradrenaline(1+)
def: "An organic cation that is the conjugate acid of (R)-noradrenaline, obtained by protonation of the primary amino group; major species at pH 7.3." []
subset: 3:STAR
synonym: "(2R)-2-(3,4-dihydroxyphenyl)-2-hydroxyethanaminium" EXACT IUPAC:NAME [IUPAC]
synonym: "(2R)-2-(3,4-dihydroxyphenyl)-2-hydroxyethanaminium" RELATED IUPAC:NAME [iupac]
synonym: "(R)-noradrenaline" RELATED [uniprot_ft]
synonym: "(R)-noradrenaline cation" RELATED [chebi]
synonym: "(R)-noradrenalinium cation" RELATED [chebi]
synonym: "(R)-noradrenalinium(1+)" RELATED [chebi]
xref: pdb-ccd:E5E {source="pdb-ccd"}
is_a: BFO:0000004 ! independent continuant
is_a: CHEBI:166902 ! noradrenaline(1+)
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018034 CHEBI:18357 ! is protonated form of (R)-noradrenaline
relationship: RO:0018039 CHEBI:234420 ! is enantiomer of (S)-noradrenaline(1+)
[Term]
id: CHEBI:72695
name: organic molecule
def: "Any molecule that consists of at least one carbon atom as part of the electrically neutral entity." []
subset: 3:STAR
synonym: "organic compound" RELATED [chebi]
synonym: "organic compounds" RELATED [chebi]
synonym: "organic molecules" RELATED [chebi]
is_a: CHEBI:25367 ! molecule
is_a: CHEBI:50860 ! organic molecular entity
[Term]
id: CHEBI:72813
name: exopolysaccharide
def: "A biomacromolecule composed of carbohydrate residues which is secreted by a microorganism into the surrounding environment." []
subset: 3:STAR
synonym: "exopolysaccharides" RELATED [chebi]
synonym: "extracellular polymeric substance" RELATED [chebi]
synonym: "extracellular polymeric substances" RELATED [chebi]
xref: metacyc.compound:Exopolysaccharides {source="metacyc.compound"}
xref: pubmed:11160795 {source="pubmed"}
xref: pubmed:11785425 {source="pubmed"}
xref: pubmed:1444258 {source="pubmed"}
xref: pubmed:15738217 {source="pubmed"}
xref: pubmed:16075348 {source="pubmed"}
xref: pubmed:17440912 {source="pubmed"}
xref: pubmed:18097339 {source="pubmed"}
xref: pubmed:19453747 {source="pubmed"}
xref: pubmed:20172021 {source="pubmed"}
xref: pubmed:20631870 {source="pubmed"}
xref: pubmed:20718297 {source="pubmed"}
xref: pubmed:2688547 {source="pubmed"}
xref: pubmed:6354590 {source="pubmed"}
xref: wikipedia.en:Exopolysaccharide {source="wikipedia.en"}
xref: wikipedia.en:Extracellular_polymeric_substance {source="wikipedia.en"}
is_a: CHEBI:33694 ! biomacromolecule
[Term]
id: CHEBI:73336
name: vulnerary
def: "A drug used in treating and healing of wounds." []
subset: 3:STAR
synonym: "vulneraries" RELATED [chebi]
synonym: "wound-healing agent" RELATED [chebi]
synonym: "wound-healing agents" RELATED [chebi]
synonym: "wound-healing drug" RELATED [chebi]
synonym: "wound-healing drugs" RELATED [chebi]
xref: wikipedia.en:Wound_healing {source="wikipedia.en"}
is_a: CHEBI:23888 ! drug
[Term]
id: CHEBI:73398
name: indole skeleton
def: "A mancude heterobicyclic organic group consisting of a benzene ring fused to a pyrrole ring." []
subset: 3:STAR
is_a: CHEBI:73541 ! organic heterobicyclic ring
[Term]
id: CHEBI:73541
name: organic heterobicyclic ring
def: "A bicyclic organic group that contains both carbon and hetero atoms." []
subset: 3:STAR
synonym: "organic heterobicyclic rings" RELATED [chebi]
is_a: CHEBI:52845 ! cyclic organic group
[Term]
id: CHEBI:73690
name: erythrose 4-phosphate/phosphoenolpyruvate family amino acid
def: "An L-α-amino acid which is biosynthesised from erythrose 4-phosphate and phosphoenolpyruvate (i.e. phenylalanine, tyrosine, and tryptophan). A closed class." []
subset: 3:STAR
synonym: "erythrose 4-phosphate and phosphoenolpyruvate family amino acid" RELATED [chebi]
synonym: "erythrose 4-phosphate and phosphoenolpyruvate family amino acids" RELATED [chebi]
synonym: "erythrose 4-phosphate family amino acid" RELATED [chebi]
synonym: "erythrose 4-phosphate family amino acids" RELATED [chebi]
synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acids" RELATED [chebi]
synonym: "phosphoenolpyruvate family amino acid" RELATED [chebi]
synonym: "phosphoenolpyruvate family amino acids" RELATED [chebi]
is_a: CHEBI:15705 ! L-alpha-amino acid
is_a: CHEBI:83813 ! proteinogenic amino acid
[Term]
id: CHEBI:74656
name: O(4)-phosphonato-D-tyrosine(2-)
def: "An optically active form of O4-phosphonatotyrosine(2−) having D-configuration." []
subset: 3:STAR
synonym: "(2R)-2-ammonio-3-[4-(phosphonatooxy)phenyl]propanoate" RELATED [iupac]
synonym: "(2R)-2-azaniumyl-3-[4-(phosphonatooxy)phenyl]propanoate" EXACT IUPAC:NAME [IUPAC]
synonym: "(2R)-2-azaniumyl-3-[4-(phosphonatooxy)phenyl]propanoate" RELATED IUPAC:NAME [iupac]
synonym: "O(4)-phospho-D-tyrosine(2-)" RELATED [chebi]
synonym: "O-phospho-D-tyrosine(2-)" RELATED [submitter]
xref: metacyc.compound:CPD-3729 {source="metacyc.compound"}
is_a: CHEBI:74955 ! O(4)-phosphonatotyrosine(2-)
relationship: RO:0018039 CHEBI:62338 ! is enantiomer of O(4)-phosphonato-L-tyrosine(2-)
[Term]
id: CHEBI:74783
name: astringent
def: "A compound that causes the contraction of body tissues, typically used to reduce bleeding from minor abrasions." []
subset: 3:STAR
synonym: "adstringent" RELATED [chebi]
synonym: "adstringents" RELATED [chebi]
synonym: "astringents" RELATED [chebi]
xref: wikipedia.en:Astringent {source="wikipedia.en"}
is_a: CHEBI:23888 ! drug
[Term]
id: CHEBI:74955
name: O(4)-phosphonatotyrosine(2-)
def: "An organophosphate oxoanion arising from deprotonation of the phospho and carboxy groups as well as protonation of the amino group of O4-phosphotyrosine" []
subset: 3:STAR
synonym: "2-ammonio-3-[4-(phosphonatooxy)phenyl]propanoate" RELATED [iupac]
synonym: "2-azaniumyl-3-[4-(phosphonatooxy)phenyl]propanoate" EXACT IUPAC:NAME [IUPAC]
synonym: "2-azaniumyl-3-[4-(phosphonatooxy)phenyl]propanoate" RELATED IUPAC:NAME [iupac]
synonym: "O(4)-phosphotyrosine(2-)" RELATED [chebi]
synonym: "O-phosphotyrosine(2-)" RELATED [chebi]
synonym: "phosphotyrosine(2-)" RELATED [chebi]
is_a: CHEBI:58945 ! organophosphate oxoanion
relationship: RO:0018033 CHEBI:74956 ! is deprotonated form of O(4)-phosphotyrosine
[Term]
id: CHEBI:74956
name: O(4)-phosphotyrosine
def: "A non-proteinogenic α-amino acid that is tyrosine phosphorylated at the phenolic hydroxy group." []
subset: 3:STAR
synonym: "O-phosphonotyrosine" EXACT IUPAC:NAME [IUPAC]
synonym: "O-phosphonotyrosine" RELATED IUPAC:NAME [iupac]
synonym: "O-phosphotyrosine" RELATED [chebi]
synonym: "phosphotyrosine" RELATED [chebi]
xref: cas:41863-47-2 {source="cas"}
xref: reaxys:4260804 {source="reaxys"}
is_a: CHEBI:21968 ! O-phosphoamino acid
is_a: CHEBI:33856 ! aromatic amino acid
is_a: CHEBI:62761 ! tyrosine derivative
is_a: CHEBI:83925 ! non-proteinogenic alpha-amino acid
relationship: RO:0018034 CHEBI:74955 ! is protonated form of O(4)-phosphonatotyrosine(2-)
[Term]
id: CHEBI:74959
name: O(4)-phospho-D-tyrosine
def: "A D-tyrosine derivative that is D-tyrosine phosphorylated at the phenolic hydroxy group." []
subset: 3:STAR
synonym: "O-phospho-D-tyrosine" RELATED [chebi]
synonym: "O-phosphono-D-tyrosine" EXACT IUPAC:NAME [IUPAC]
synonym: "O-phosphono-D-tyrosine" RELATED IUPAC:NAME [iupac]
xref: metacyc.compound:CPD-3729 {source="metacyc.compound"}
xref: reaxys:13579292 {source="reaxys"}
is_a: CHEBI:16733 ! D-alpha-amino acid
is_a: CHEBI:74956 ! O(4)-phosphotyrosine
is_a: CHEBI:84124 ! D-tyrosine derivative
relationship: RO:0018039 CHEBI:37788 ! is enantiomer of O(4)-phospho-L-tyrosine
[Term]
id: CHEBI:75600
name: EC 6.3.* (C-N bond-forming ligase) inhibitor
def: "A ligase inhibitor that interferes with the action of a C‒N bond-forming ligase (EC 6.3.*.*)." []
subset: 3:STAR
synonym: "C--N bond-forming ligase inhibitor" RELATED [chebi]
synonym: "C--N bond-forming ligase inhibitors" RELATED [chebi]
synonym: "C-N bond-forming ligase (EC 6.3.*) inhibitor" RELATED [chebi]
synonym: "C-N bond-forming ligase (EC 6.3.*) inhibitors" RELATED [chebi]
synonym: "C-N bond-forming ligase inhibitor" RELATED [chebi]
synonym: "C-N bond-forming ligase inhibitors" RELATED [chebi]
synonym: "EC 6.3.* (C-N bond-forming ligase) inhibitorS" RELATED [chebi]
synonym: "EC 6.3.* inhibitor" RELATED [chebi]
synonym: "EC 6.3.* inhibitors" RELATED [chebi]
synonym: "EC 6.3.*.* inhibitor" RELATED [chebi]
synonym: "EC 6.3.*.* inhibitors" RELATED [chebi]
is_a: CHEBI:75603 ! EC 6.* (ligase) inhibitor
[Term]
id: CHEBI:75603
name: EC 6.* (ligase) inhibitor
def: "Any enzyme inhibitor that interferes with the action of a ligase (EC 6.*.*.*). Ligases are enzymes that catalyse the joining of two molecules with concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." []
subset: 3:STAR
synonym: "EC 6.* (ligase) inhibitors" RELATED [chebi]
synonym: "EC 6.* inhibitor" RELATED [chebi]
synonym: "EC 6.* inhibitors" RELATED [chebi]
synonym: "EC 6.*.*.* inhibitor" RELATED [chebi]
synonym: "EC 6.*.*.* inhibitors" RELATED [chebi]
synonym: "ligase inhibitor" RELATED [chebi]
synonym: "ligase inhibitors" RELATED [chebi]
xref: wikipedia.en:Ligase {source="wikipedia.en"}
is_a: CHEBI:23924 ! enzyme inhibitor
[Term]
id: CHEBI:75763
name: eukaryotic metabolite
def: "Any metabolite produced during a metabolic reaction in eukaryotes, the taxon that include members of the fungi, plantae and animalia kingdoms." []
subset: 3:STAR
synonym: "eukaryotic metabolites" RELATED [chebi]
is_a: CHEBI:25212 ! metabolite
[Term]
id: CHEBI:75767
name: animal metabolite
alt_id: CHEBI:77721
alt_id: CHEBI:77743
def: "Any eukaryotic metabolite produced during a metabolic reaction in animals that include diverse creatures from sponges, insects to mammals." []
subset: 3:STAR
synonym: "animal metabolites" RELATED [chebi]
is_a: CHEBI:75763 ! eukaryotic metabolite
[Term]
id: CHEBI:75768
name: mammalian metabolite
alt_id: CHEBI:77464
alt_id: CHEBI:77744
def: "Any animal metabolite produced during a metabolic reaction in mammals." []
subset: 3:STAR
synonym: "mammalian metabolites" RELATED [chebi]
is_a: CHEBI:75767 ! animal metabolite
[Term]
id: CHEBI:75771
name: mouse metabolite
def: "Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus)." []
subset: 3:STAR
synonym: "mouse metabolites" RELATED [chebi]
synonym: "Mus musculus metabolite" RELATED [chebi]
synonym: "Mus musculus metabolites" RELATED [chebi]
is_a: CHEBI:75768 ! mammalian metabolite
[Term]
id: CHEBI:75772
name: Saccharomyces cerevisiae metabolite
alt_id: CHEBI:76949
alt_id: CHEBI:76951
def: "Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae )." []
subset: 3:STAR
synonym: "baker's yeast metabolite" RELATED [chebi]
synonym: "baker's yeast metabolites" RELATED [chebi]
synonym: "baker's yeast secondary metabolite" RELATED [chebi]
synonym: "baker's yeast secondary metabolites" RELATED [chebi]
synonym: "S. cerevisiae metabolite" RELATED [chebi]
synonym: "S. cerevisiae metabolites" RELATED [chebi]
synonym: "S. cerevisiae secondary metabolite" RELATED [chebi]
synonym: "S. cerevisiae secondary metabolites" RELATED [chebi]
synonym: "Saccharomyces cerevisiae metabolites" RELATED [chebi]
synonym: "Saccharomyces cerevisiae secondary metabolites" RELATED [chebi]
is_a: CHEBI:76946 ! fungal metabolite
[Term]
id: CHEBI:75787
name: prokaryotic metabolite
def: "Any metabolite produced during a metabolic reaction in prokaryotes, the taxon that include members of domains such as the bacteria and archaea." []
subset: 3:STAR
synonym: "prokaryotic metabolites" RELATED [chebi]
is_a: CHEBI:25212 ! metabolite
[Term]
id: CHEBI:76042
name: aromatic amino-acid zwitterion
def: "An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of any aromatic amino-acid." []
subset: 3:STAR
synonym: "an aromatic amino-acid" RELATED [uniprot_ft]
synonym: "aromatic amino-acid zwitterions" RELATED [chebi]
xref: metacyc.compound:Aromatic-Amino-Acids {source="metacyc.compound"}
is_a: CHEBI:35238 ! amino-acid zwitterion
relationship: RO:0018036 CHEBI:33856 ! is tautomer of aromatic amino acid
[Term]
id: CHEBI:76206
name: xenobiotic metabolite
def: "Any metabolite produced by metabolism of a xenobiotic compound." []
subset: 3:STAR
synonym: "xenobiotic metabolites" RELATED [chebi]
is_a: CHEBI:25212 ! metabolite
[Term]
id: CHEBI:76413
name: greenhouse gas
def: "A gas in an atmosphere that absorbs and emits radiation within the thermal infrared range, so contributing to the 'greenhouse effect'." []
subset: 3:STAR
synonym: "greenhouse gases" RELATED [chebi]
xref: wikipedia.en:Greenhouse_gas {source="wikipedia.en"}
is_a: CHEBI:51086 ! chemical role
[Term]
id: CHEBI:76414
name: propellant
def: "A compressed gas or liquid with a boiling point lower than room temperature which to used to propel and dispense liquids such as deodorants, insecticides, paints, etc. from aerosol cans." []
subset: 3:STAR
synonym: "propellants" RELATED [chebi]
xref: pubmed:22519407 {source="pubmed"}
xref: pubmed:24001847 {source="pubmed"}
is_a: CHEBI:33232 ! application
[Term]
id: CHEBI:76725
name: EC 1.* (oxidoreductase) inhibitor
def: "An enzyme inhibitor which interferes with the action of an oxidoreductase (EC 1.*.*.*)." []
subset: 3:STAR
synonym: "EC 1.* (oxidoreductase) inhibitors" RELATED [chebi]
synonym: "EC 1.* inhibitor" RELATED [chebi]
synonym: "EC 1.* inhibitors" RELATED [chebi]
synonym: "oxidoreductase (EC 1.*) inhibitor" RELATED [chebi]
synonym: "oxidoreductase (EC 1.*) inhibitors" RELATED [chebi]
synonym: "oxidoreductase inhibitor" RELATED [chebi]
synonym: "oxidoreductase inhibitors" RELATED [chebi]
xref: wikipedia.en:Oxidoreductase {source="wikipedia.en"}
is_a: CHEBI:23924 ! enzyme inhibitor
[Term]
id: CHEBI:76729
name: EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor
def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH-CH group of donors (EC 1.3.*.*)." []
subset: 3:STAR
synonym: "EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitors" RELATED [chebi]
synonym: "EC 1.3.* inhibitor" RELATED [chebi]
synonym: "EC 1.3.* inhibitors" RELATED [chebi]
synonym: "inhibitor of oxidoreductase acting on CH-CH group of donor" RELATED [chebi]
synonym: "inhibitor of oxidoreductase acting on CH-CH group of donors" RELATED [chebi]
synonym: "inhibitors of oxidoreductase acting on CH-CH group of donor" RELATED [chebi]
synonym: "inhibitors of oxidoreductase acting on CH-CH group of donors" RELATED [chebi]
synonym: "oxidoreductase acting on donor CH-CH group (EC 1.3.*) inhibitor" RELATED [chebi]
synonym: "oxidoreductase acting on donor CH-CH group (EC 1.3.*) inhibitors" RELATED [chebi]
synonym: "oxidoreductase acting on donor CH-CH group inhibitor" RELATED [chebi]
synonym: "oxidoreductase acting on donor CH-CH group inhibitors" RELATED [chebi]
is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor
[Term]
id: CHEBI:76759
name: EC 3.* (hydrolase) inhibitor
def: "Any enzyme inhibitor that interferes with the action of a hydrolase (EC 3.*.*.*)." []
subset: 3:STAR
synonym: "EC 3.* (hydrolase) inhibitors" RELATED [chebi]
synonym: "EC 3.* inhibitor" RELATED [chebi]
synonym: "EC 3.* inhibitors" RELATED [chebi]
synonym: "EC 3.*.*.* inhibitor" RELATED [chebi]
synonym: "EC 3.*.*.* inhibitors" RELATED [chebi]
synonym: "hydrolase (EC 3.*) inhibitor" RELATED [chebi]
synonym: "hydrolase (EC 3.*) inhibitors" RELATED [chebi]
synonym: "hydrolase inhibitor" RELATED [chebi]
synonym: "hydrolase inhibitors" RELATED [chebi]
xref: wikipedia.en:Hydrolase {source="wikipedia.en"}
is_a: CHEBI:23924 ! enzyme inhibitor
[Term]
id: CHEBI:76760
name: EC 3.1.* (ester hydrolase) inhibitor
def: "A hydrolase inhibitor that interferes with the action of any ester hydrolase (EC 3.1.*.*)." []
subset: 3:STAR
synonym: "EC 3.1.* (ester hydrolase) inhibitors" RELATED [chebi]
synonym: "EC 3.1.* inhibitor" RELATED [chebi]
synonym: "EC 3.1.* inhibitors" RELATED [chebi]
synonym: "ester hydrolase (EC 3.1.*) inhibitor" RELATED [chebi]
synonym: "ester hydrolase (EC 3.1.*) inhibitors" RELATED [chebi]
synonym: "ester hydrolase inhibitor" RELATED [chebi]
synonym: "ester hydrolase inhibitors" RELATED [chebi]
is_a: CHEBI:76759 ! EC 3.* (hydrolase) inhibitor
[Term]
id: CHEBI:76764
name: EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor
def: "Any hydrolase inhibitor that interferes with the action of a hydrolase acting on C-N bonds, other than peptide bonds (EC 3.5.*.*)." []
subset: 3:STAR
synonym: "EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitor" RELATED [chebi]
synonym: "EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitors" RELATED [chebi]
synonym: "EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitor" RELATED [chebi]
synonym: "EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitors" RELATED [chebi]
synonym: "EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitors" RELATED [chebi]
synonym: "EC 3.5.* inhibitor" RELATED [chebi]
synonym: "EC 3.5.* inhibitors" RELATED [chebi]
is_a: CHEBI:76759 ! EC 3.* (hydrolase) inhibitor
[Term]
id: CHEBI:76775
name: EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor
def: "An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of any phosphoric monoester hydrolase (EC 3.1.3.*)." []
subset: 3:STAR
synonym: "EC 3.1.3.* (phosphoric monoester hydrolase) inhibitors" RELATED [chebi]
synonym: "EC 3.1.3.* inhibitor" RELATED [chebi]
synonym: "EC 3.1.3.* inhibitors" RELATED [chebi]
synonym: "inhibitor of phosphoric monoester hydrolase" RELATED [chebi]
synonym: "inhibitor of phosphoric monoester hydrolase (EC 3.1.3.*)" RELATED [chebi]
synonym: "inhibitors of phosphoric monoester hydrolase" RELATED [chebi]
synonym: "inhibitors of phosphoric monoester hydrolase (EC 3.1.3.*)" RELATED [chebi]
synonym: "phosphoric monoester hydrolase (EC 3.1.3.*) inhibitor" RELATED [chebi]
synonym: "phosphoric monoester hydrolase (EC 3.1.3.*) inhibitors" RELATED [chebi]
synonym: "phosphoric monoester hydrolase inhibitor" RELATED [chebi]
synonym: "phosphoric monoester hydrolase inhibitors" RELATED [chebi]
is_a: CHEBI:76760 ! EC 3.1.* (ester hydrolase) inhibitor
[Term]
id: CHEBI:76807
name: EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor
def: "An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any non-peptide linear amide C-N hydrolase (EC 3.5.1.*)." []
subset: 3:STAR
synonym: "EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitors" RELATED [chebi]
synonym: "EC 3.5.1.* inhibitor" RELATED [chebi]
synonym: "EC 3.5.1.* inhibitors" RELATED [chebi]
synonym: "non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitor" RELATED [chebi]
synonym: "non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitors" RELATED [chebi]
is_a: CHEBI:76764 ! EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor
[Term]
id: CHEBI:76823
name: EC 6.3.1.* (acid-ammonia/amine ligase) inhibitor
def: "An EC 6.3.* (C‒N bond-forming ligase) inhibitor that interferes with the action of any acid-ammonia (or amine) ligase (EC 6.3.1.*)." []
subset: 3:STAR
synonym: "acid-ammonia (or amine) ligase inhibitor" RELATED [chebi]
synonym: "acid-ammonia (or amine) ligase inhibitors" RELATED [chebi]
synonym: "EC 6.3.1.* (acid-ammonia/amine ligase) inhibitors" RELATED [chebi]
synonym: "EC 6.3.1.* inhibitor" RELATED [chebi]
synonym: "EC 6.3.1.* inhibitors" RELATED [chebi]
is_a: CHEBI:75600 ! EC 6.3.* (C-N bond-forming ligase) inhibitor
[Term]
id: CHEBI:76857
name: EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor
def: "An EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor that interferes with the action of any such enzyme using NAD+ or NADP+ as acceptor (EC 1.3.1.*)." []
subset: 3:STAR
synonym: "EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor with NAD(+) or NADP(+) as acceptor) inhibitor" RELATED [chebi]
synonym: "EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor with NAD(+) or NADP(+) as acceptor) inhibitors" RELATED [chebi]
synonym: "EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor, NAD(+) or NADP(+) as acceptor) inhibitor" RELATED [chebi]
synonym: "EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor, NAD(+) or NADP(+) as acceptor) inhibitors" RELATED [chebi]
synonym: "EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitors" RELATED [chebi]
synonym: "EC 1.3.1.* inhibitor" RELATED [chebi]
synonym: "EC 1.3.1.* inhibitors" RELATED [chebi]
synonym: "oxidoreductase acting on CH-CH group of donor with NAD(+) or NADP(+) as acceptor (EC 1.3.1.*) inhibitor" RELATED [chebi]
synonym: "oxidoreductase acting on CH-CH group of donor with NAD(+) or NADP(+) as acceptor (EC 1.3.1.*) inhibitors" RELATED [chebi]
is_a: CHEBI:76729 ! EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor
[Term]
id: CHEBI:76924
name: plant metabolite
alt_id: CHEBI:75766
alt_id: CHEBI:76925
def: "Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms." []
subset: 3:STAR
synonym: "plant metabolites" RELATED [chebi]
synonym: "plant secondary metabolites" RELATED [chebi]
is_a: CHEBI:75763 ! eukaryotic metabolite
[Term]
id: CHEBI:76946
name: fungal metabolite
alt_id: CHEBI:75765
alt_id: CHEBI:76947
def: "Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds." []
subset: 3:STAR
synonym: "fungal metabolites" RELATED [chebi]
is_a: CHEBI:75763 ! eukaryotic metabolite
[Term]
id: CHEBI:76967
name: human xenobiotic metabolite
def: "Any human metabolite produced by metabolism of a xenobiotic compound in humans." []
subset: 3:STAR
synonym: "human xenobiotic metabolites" RELATED [chebi]
is_a: CHEBI:76206 ! xenobiotic metabolite
is_a: CHEBI:77746 ! human metabolite
[Term]
id: CHEBI:76969
name: bacterial metabolite
alt_id: CHEBI:75760
alt_id: CHEBI:76970
def: "Any prokaryotic metabolite produced during a metabolic reaction in bacteria." []
subset: 3:STAR
is_a: CHEBI:75787 ! prokaryotic metabolite
[Term]
id: CHEBI:76971
name: Escherichia coli metabolite
def: "Any bacterial metabolite produced during a metabolic reaction in Escherichia coli." []
subset: 3:STAR
synonym: "E.coli metabolite" RELATED [chebi]
synonym: "E.coli metabolites" RELATED [chebi]
synonym: "Escherichia coli metabolites" RELATED [chebi]
is_a: CHEBI:76969 ! bacterial metabolite
[Term]
id: CHEBI:77182
name: food colouring
def: "A food additive that imparts colour to food. In European countries, E-numbers for permitted food colours are from E 100 to E 199, divided into yellows (E 100-109), oranges (E 110-119), reds (E 120-129), blues and violets (E 130-139), greens (E 140-149), browns and blacks (E 150-159), and others (E 160-199)." []
subset: 3:STAR
synonym: "food coloring" RELATED [chebi]
synonym: "food colorings" RELATED [chebi]
synonym: "food colourings" RELATED [chebi]
xref: wikipedia.en:Food_coloring {source="wikipedia.en"}
is_a: CHEBI:64047 ! food additive
[Term]
id: CHEBI:77746
name: human metabolite
alt_id: CHEBI:75770
alt_id: CHEBI:77123
def: "Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens)." []
subset: 3:STAR
synonym: "H. sapiens metabolite" RELATED [chebi]
synonym: "H. sapiens metabolites" RELATED [chebi]
synonym: "Homo sapiens metabolite" RELATED [chebi]
synonym: "Homo sapiens metabolites" RELATED [chebi]
is_a: CHEBI:75768 ! mammalian metabolite
[Term]
id: CHEBI:77941
name: EC 3.5.1.4 (amidase) inhibitor
def: "An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of amidase (EC 3.5.1.4)." []
subset: 3:STAR
synonym: "acylamidase inhibitor" RELATED [chebi]
synonym: "acylamidase inhibitors" RELATED [chebi]
synonym: "acylamide amidohydrolase inhibitor" RELATED [chebi]
synonym: "acylamide amidohydrolase inhibitors" RELATED [chebi]
synonym: "amidase (EC 3.5.1.4) inhibitor" RELATED [chebi]
synonym: "amidase (EC 3.5.1.4) inhibitors" RELATED [chebi]
synonym: "amidase inhibitor" RELATED [chebi]
synonym: "amidase inhibitors" RELATED [chebi]
synonym: "amidohydrolase inhibitor" RELATED [chebi]
synonym: "amidohydrolase inhibitors" RELATED [chebi]
synonym: "deaminase inhibitor" RELATED [chebi]
synonym: "deaminase inhibitors" RELATED [chebi]
synonym: "EC 3.5.1.4 (amidase) inhibitors" RELATED [chebi]
synonym: "EC 3.5.1.4 inhibitor" RELATED [chebi]
synonym: "EC 3.5.1.4 inhibitors" RELATED [chebi]
synonym: "fatty acylamidase inhibitor" RELATED [chebi]
synonym: "fatty acylamidase inhibitors" RELATED [chebi]
synonym: "N-acetylaminohydrolase inhibitor" RELATED [chebi]
synonym: "N-acetylaminohydrolase inhibitors" RELATED [chebi]
xref: wikipedia.en:Amidase {source="wikipedia.en"}
is_a: CHEBI:76807 ! EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor
[Term]
id: CHEBI:77960
name: food firming agent
def: "A food additive that is used to make or keep fruit or vegetable tissues firm and crisp. or which interacts with gelling agents such as pectin to produce or strengthen a gel." []
subset: 3:STAR
synonym: "firming agent" RELATED [chebi]
synonym: "firming agents" RELATED [chebi]
synonym: "food firming agents" RELATED [chebi]
xref: wikipedia.en:Firming_agent {source="wikipedia.en"}
is_a: CHEBI:64047 ! food additive
[Term]
id: CHEBI:77974
name: food packaging gas
def: "A food additive that is a (generally inert) gas which is used to envelop foodstuffs during packing and so protect them from unwanted chemical reactions such as food spoilage or oxidation during subsequent transport and storage. The term includes propellant gases, used to expel foods from a container." []
subset: 3:STAR
synonym: "food packaging gases" RELATED [chebi]
xref: wikipedia.en:Packaging_gas {source="wikipedia.en"}
is_a: CHEBI:64047 ! food additive
[Term]
id: CHEBI:78017
name: food propellant
def: "A propellant that is used to expel foods from an aerosol container." []
subset: 3:STAR
synonym: "food propellants" RELATED [chebi]
is_a: CHEBI:64047 ! food additive
is_a: CHEBI:76414 ! propellant
[Term]
id: CHEBI:78113
name: fatty acid anion 3:0
def: "Any saturated fatty acid anion containing 3 carbons. Formed by deprotonation of the carboxylic acid moiety. Major species at pH 7.3." []
subset: 3:STAR
synonym: "fatty acid 3:0" RELATED [uniprot_ft]
is_a: CHEBI:58951 ! short-chain fatty acid anion
is_a: CHEBI:58953 ! saturated fatty acid anion
[Term]
id: CHEBI:78115
name: fatty acid anion 4:0
def: "Any saturated fatty acid anion containing 4 carbons. Formed by deprotonation of the carboxylic acid moiety. Major species at pH 7.3." []
subset: 3:STAR
synonym: "fatty acid 4:0" RELATED [uniprot_ft]
is_a: CHEBI:58951 ! short-chain fatty acid anion
is_a: CHEBI:58953 ! saturated fatty acid anion
relationship: RO:0018033 CHEBI:140601 ! is deprotonated form of fatty acid 4:0
[Term]
id: CHEBI:78295
name: food component
def: "A physiological role played by any substance that is distributed in foodstuffs. It includes materials derived from plants or animals, such as vitamins or minerals, as well as environmental contaminants." []
subset: 3:STAR
synonym: "dietary component" RELATED [chebi]
synonym: "dietary components" RELATED [chebi]
synonym: "food components" RELATED [chebi]
is_a: CHEBI:52211 ! physiological role
[Term]
id: CHEBI:78298
name: environmental contaminant
def: "Any minor or unwanted substance introduced into the environment that can have undesired effects." []
subset: 3:STAR
synonym: "environmental contaminants" RELATED [chebi]
is_a: CHEBI:51086 ! chemical role
[Term]
id: CHEBI:78433
name: refrigerant
def: "A substance used in a thermodynamic heat pump cycle or refrigeration cycle that undergoes a phase change from a gas to a liquid and back. Refrigerants are used in air-conditioning systems and freezers or refrigerators and are assigned a \"R\" number (by ASHRAE - formerly the American Society of Heating, Refrigerating and Air Conditioning Engineers), which is determined systematically according to their molecular structure." []
subset: 3:STAR
synonym: "refrigerants" RELATED [chebi]
xref: wikipedia.en:Refrigerant {source="wikipedia.en"}
is_a: CHEBI:33232 ! application
[Term]
id: CHEBI:78608
name: alpha-amino-acid zwitterion
alt_id: CHEBI:83409
def: "An amino acid-zwitterion obtained by transfer of a proton from the carboxy to the amino group of any α-amino acid; major species at pH 7.3." []
subset: 3:STAR
synonym: "alpha-amino acid zwitterion" RELATED [chebi]
synonym: "alpha-amino acid zwitterions" RELATED [chebi]
synonym: "alpha-amino-acid zwitterions" RELATED [chebi]
synonym: "an alpha-amino acid" RELATED [uniprot_ft]
xref: metacyc.compound:Alpha-Amino-Acids {source="metacyc.compound"}
is_a: CHEBI:35238 ! amino-acid zwitterion
relationship: RO:0018036 CHEBI:33704 ! is tautomer of alpha-amino acid
[Term]
id: CHEBI:78616
name: carbohydrates and carbohydrate derivatives
def: "Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula Cm(H2O)n; carbohydrate derivatives may contain other elements by substitution or condensation." []
subset: 3:STAR
synonym: "carbohydrates and derivatives" RELATED [chebi]
synonym: "carbohydrates and their derivatives" RELATED [chebi]
is_a: CHEBI:36963 ! organooxygen compound
[Term]
id: CHEBI:78675
name: fundamental metabolite
def: "Any metabolite produced by all living cells." []
subset: 3:STAR
synonym: "essential metabolite" RELATED [chebi]
synonym: "essential metabolites" RELATED [chebi]
synonym: "fundamental metabolites" RELATED [chebi]
is_a: CHEBI:25212 ! metabolite
[Term]
id: CHEBI:78840
name: olefinic compound
def: "Any organic molecular entity that contains at least one C=C bond." []
subset: 3:STAR
synonym: "olefinic compounds" RELATED [chebi]
is_a: CHEBI:50860 ! organic molecular entity
[Term]
id: CHEBI:79387
name: trivalent inorganic anion
def: "Any inorganic anion with a valency of three." []
subset: 3:STAR
synonym: "trivalent inorganic anions" RELATED [chebi]
is_a: CHEBI:24834 ! inorganic anion
[Term]
id: CHEBI:79388
name: divalent inorganic anion
def: "Any inorganic anion with a valency of two." []
subset: 3:STAR
synonym: "divalent inorganic anions" RELATED [chebi]
is_a: CHEBI:24834 ! inorganic anion
[Term]
id: CHEBI:79389
name: monovalent inorganic anion
def: "Any inorganic anion with a valency of one." []
subset: 3:STAR
synonym: "monovalent inorganic anions" RELATED [chebi]
is_a: CHEBI:24834 ! inorganic anion
[Term]
id: CHEBI:82663
name: elemental iron
def: "An elemental molecular entity in which all of the atoms have atomic number 26." []
subset: 3:STAR
is_a: CHEBI:24873 ! iron molecular entity
is_a: CHEBI:33259 ! elemental molecular entity
[Term]
id: CHEBI:83039
name: crustacean metabolite
def: "An animal metabolite produced by arthropods such as crabs, lobsters, crayfish, shrimps and krill." []
subset: 3:STAR
synonym: "crustacean metabolites" RELATED [chebi]
is_a: CHEBI:75767 ! animal metabolite
[Term]
id: CHEBI:83056
name: Daphnia magna metabolite
def: "A Daphnia metabolite produced by the species Daphnia magna." []
subset: 3:STAR
synonym: "Daphnia magna metabolites" RELATED [chebi]
is_a: CHEBI:83057 ! Daphnia metabolite
[Term]
id: CHEBI:83057
name: Daphnia metabolite
def: "A crustacean metabolite produced by the genus of small planktonic arthropods, Daphnia" []
subset: 3:STAR
synonym: "Daphnia metabolites" RELATED [chebi]
xref: wikipedia.en:Daphnia {source="wikipedia.en"}
is_a: CHEBI:83039 ! crustacean metabolite
[Term]
id: CHEBI:83228
name: L-alpha-amino acid residue
def: "An α-amino-acid residue derived from an L-α-amino acid." []
subset: 3:STAR
synonym: "an L-alpha amino acid residue" RELATED [uniprot_ft]
synonym: "L-alpha-amino acid residue" RELATED [chebi]
synonym: "L-alpha-amino acid residues" RELATED [chebi]
is_a: CHEBI:33710 ! alpha-amino-acid residue
relationship: RO:0018037 CHEBI:15705 ! is substitutent group from L-alpha-amino acid
[Term]
id: CHEBI:8337
name: porphyrin
subset: 3:STAR
synonym: "21H,23H-Porphin" RELATED [nist]
synonym: "21H,23H-porphine" RELATED [nist]
synonym: "porphine" RELATED [chemidplus]
synonym: "Porphyrin" RELATED [kegg.compound]
synonym: "porphyrin" EXACT IUPAC:NAME [IUPAC]
synonym: "porphyrin" RELATED IUPAC:NAME [iupac]
xref: beilstein:1222991 {source="beilstein"}
xref: beilstein:36080 {source="beilstein"}
xref: beilstein:622855 {source="beilstein"}
xref: cas:101-60-0 {source="cas"}
xref: gmelin:205920 {source="gmelin"}
xref: hmdb:HMDB0000839 {source="hmdb"}
xref: kegg.compound:C05113 {source="kegg.compound"}
xref: pubmed:22735334 {source="pubmed"}
xref: reaxys:1160988 {source="reaxys"}
xref: wikipedia.en:Porphyrin {source="wikipedia.en"}
is_a: CHEBI:26214 ! porphyrins
is_a: CHEBI:35794 ! tetrapyrrole fundamental parent
relationship: RO:0000087 CHEBI:25212 ! has role metabolite
[Term]
id: CHEBI:83811
name: proteinogenic amino acid derivative
def: "Any derivative of a proteinogenic amino acid resulting from reaction at an amino group, carboxy group, or a side-chain functional group, or from the replacement of any hydrogen by a heteroatom." []
subset: 3:STAR
synonym: "canonical amino acid derivative" RELATED [chebi]
synonym: "canonical amino acid derivatives" RELATED [chebi]
synonym: "canonical amino-acid derivative" RELATED [chebi]
synonym: "canonical amino-acid derivatives" RELATED [chebi]
synonym: "proteinogenic amino acid derivatives" RELATED [chebi]
synonym: "proteinogenic amino-acid derivative" RELATED [chebi]
synonym: "proteinogenic amino-acid derivatives" RELATED [chebi]
is_a: CHEBI:83821 ! amino-acid derivative
relationship: RO:0018038 CHEBI:83813 ! has functional parent proteinogenic amino acid
[Term]
id: CHEBI:83812
name: non-proteinogenic amino acid derivative
def: "Any derivative of a non-proteinogenic amino acid resulting from reaction at an amino group or carboxy group, or from the replacement of any hydrogen by a heteroatom." []
subset: 3:STAR
synonym: "non-canonical amino acid derivative" RELATED [chebi]
synonym: "non-canonical amino-acid derivatives" RELATED [chebi]
synonym: "non-proteinogenic amino-acid derivatives" RELATED [chebi]
is_a: CHEBI:83821 ! amino-acid derivative
[Term]
id: CHEBI:83813
name: proteinogenic amino acid
def: "Any of the 23 α-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and N-formylmethionine. Apart from glycine, which is non-chiral, all have L configuration." []
subset: 3:STAR
synonym: "canonical amino acid" RELATED [chebi]
synonym: "canonical amino acids" RELATED [chebi]
synonym: "proteinogenic amino acids" RELATED [chebi]
xref: wikipedia.en:Proteinogenic_amino_acid {source="wikipedia.en"}
is_a: CHEBI:33709 ! amino acid
[Term]
id: CHEBI:83820
name: non-proteinogenic amino acid
def: "Any amino-acid that is not naturally encoded in the genetic code of any organism." []
subset: 3:STAR
synonym: "non-canonical amino acid" RELATED [chebi]
synonym: "non-canonical amino acids" RELATED [chebi]
synonym: "non-canonical amino-acid" RELATED [chebi]
synonym: "non-canonical amino-acids" RELATED [chebi]
synonym: "non-coded amino acid" RELATED [chebi]
synonym: "non-coded amino acids" RELATED [chebi]
synonym: "non-coded amino-acid" RELATED [chebi]
synonym: "non-coded amino-acids" RELATED [chebi]
synonym: "non-proteinogenic amino acids" RELATED [chebi]
synonym: "non-proteinogenic amino-acid" RELATED [chebi]
synonym: "non-proteinogenic amino-acids" RELATED [chebi]
xref: wikipedia.en:Non-proteinogenic_amino_acids {source="wikipedia.en"}
is_a: CHEBI:33709 ! amino acid
[Term]
id: CHEBI:83821
name: amino-acid derivative
alt_id: CHEBI:25359
def: "Any derivative of an amino acid resulting from reaction at an amino group, carboxy group, side-chain functional group, or from the replacement of any hydrogen by a heteroatom. The definition normally excludes peptides containing amino acid residues." []
subset: 3:STAR
synonym: "amino acid derivative" RELATED [chebi]
synonym: "amino acid derivatives" RELATED [chebi]
synonym: "amino-acid derivatives" RELATED [chebi]
synonym: "modified amino acids" RELATED [chebi]
is_a: CHEBI:35352 ! organonitrogen compound
[Term]
id: CHEBI:83822
name: non-proteinogenic L-alpha-amino acid
def: "Any L-α-amino acid which is not a member of the group of 23 proteinogenic amino acids." []
subset: 3:STAR
synonym: "non-proteinogenic L-alpha-amino acids" RELATED [chebi]
is_a: CHEBI:15705 ! L-alpha-amino acid
is_a: CHEBI:83925 ! non-proteinogenic alpha-amino acid
[Term]
id: CHEBI:8386
name: pregnane
subset: 3:STAR
synonym: "pregnane" EXACT IUPAC:NAME [IUPAC]
synonym: "pregnane" RELATED IUPAC:NAME [iupac]
xref: lipidmaps:LMST02030000 {source="lipidmaps"}
xref: wikipedia.en:Pregnane {source="wikipedia.en"}
is_a: CHEBI:35508 ! steroid fundamental parent
[Term]
id: CHEBI:83925
name: non-proteinogenic alpha-amino acid
def: "Any α-amino acid which is not a member of the group of 23 proteinogenic amino acids." []
subset: 3:STAR
synonym: "non-proteinogenic alpha-amino acids" RELATED [chebi]
synonym: "non-proteinogenic alpha-amino-acid" RELATED [chebi]
synonym: "non-proteinogenic alpha-amino-acids" RELATED [chebi]
is_a: CHEBI:33704 ! alpha-amino acid
is_a: CHEBI:83820 ! non-proteinogenic amino acid
[Term]
id: CHEBI:84055
name: pentose phosphate
def: "Any phospho sugar that is the phosphate derivative of pentose." []
subset: 3:STAR
synonym: "pentose phosphates" RELATED [chebi]
is_a: CHEBI:33447 ! phospho sugar
is_a: CHEBI:63409 ! pentose derivative
[Term]
id: CHEBI:84087
name: human urinary metabolite
def: "Any metabolite (endogenous or exogenous) found in human urine samples." []
subset: 3:STAR
synonym: "human urinary metabolites" RELATED [chebi]
is_a: CHEBI:77746 ! human metabolite
[Term]
id: CHEBI:84124
name: D-tyrosine derivative
def: "A non-proteinogenic amino acid derivative resulting from reaction of D-tyrosine at the amino group or the carboxy group, or from the replacement of any hydrogen of D-tyrosine by a heteroatom." []
subset: 3:STAR
synonym: "D-tyrosine derivatives" RELATED [chebi]
is_a: CHEBI:62761 ! tyrosine derivative
is_a: CHEBI:84143 ! D-phenylalanine derivative
relationship: RO:0018038 CHEBI:28479 ! has functional parent D-tyrosine
[Term]
id: CHEBI:84143
name: D-phenylalanine derivative
def: "A non-proteinogenic amino acid derivative resulting from reaction of D-phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of D-phenylalanine by a heteroatom." []
subset: 3:STAR
synonym: "D-phenylalanine derivatives" RELATED [chebi]
is_a: CHEBI:25985 ! phenylalanine derivative
is_a: CHEBI:83812 ! non-proteinogenic amino acid derivative
relationship: RO:0018038 CHEBI:16998 ! has functional parent D-phenylalanine
[Term]
id: CHEBI:84144
name: L-phenylalanine derivative
def: "A proteinogenic amino acid derivative resulting from reaction of L-phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of L-phenylalanine by a heteroatom." []
subset: 3:STAR
synonym: "L-phenylalanine derivatives" RELATED [chebi]
is_a: CHEBI:25985 ! phenylalanine derivative
is_a: CHEBI:83811 ! proteinogenic amino acid derivative
relationship: RO:0018038 CHEBI:17295 ! has functional parent L-phenylalanine
[Term]
id: CHEBI:84387
name: (1s,4s)-prephenic acid
def: "A prephenic acid having (1s,4s)-cis-configuration." []
subset: 3:STAR
synonym: "(1s,4s)-1-(2-carboxy-2-oxoethyl)-4-hydroxycyclohexa-2,5-diene-1-carboxylic acid" EXACT IUPAC:NAME [IUPAC]
synonym: "(1s,4s)-1-(2-carboxy-2-oxoethyl)-4-hydroxycyclohexa-2,5-diene-1-carboxylic acid" RELATED IUPAC:NAME [iupac]
synonym: "cis-1-(2-carboxy-2-oxoethyl)-4-hydroxycyclohexa-2,5-diene-1-carboxylic acid" EXACT IUPAC:NAME [IUPAC]
synonym: "cis-1-(2-carboxy-2-oxoethyl)-4-hydroxycyclohexa-2,5-diene-1-carboxylic acid" RELATED IUPAC:NAME [iupac]
synonym: "cis-1-Carboxy-4-hydroxy-alpha-oxo-2,5-cyclohexadiene-1-propanoic acid" RELATED [chemidplus]
synonym: "cis-prephenic acid" RELATED [chebi]
synonym: "Prephenic acid, cis" RELATED [chemidplus]
xref: cas:126-49-8 {source="cas"}
xref: cas:87664-40-2 {source="cas"}
xref: kegg.compound:C00254 {source="kegg.compound"}
xref: metacyc.compound:PREPHENATE {source="metacyc.compound"}
xref: reaxys:2698271 {source="reaxys"}
xref: wikipedia.en:Prephenic_acid {source="wikipedia.en"}
is_a: CHEBI:16666 ! prephenic acid
relationship: RO:0018034 CHEBI:29934 ! is protonated form of (1s,4s)-prephenate(2-)
[Term]
id: CHEBI:84729
name: hydroxyindoles
def: "Any member of the class of indoles carrying at least one hydroxy group." []
subset: 3:STAR
is_a: CHEBI:24828 ! indoles
is_a: CHEBI:33822 ! organic hydroxy compound
[Term]
id: CHEBI:84735
name: algal metabolite
def: "Any eukaryotic metabolite produced during a metabolic reaction in algae including unicellular organisms like chlorella and diatoms to multicellular organisms like giant kelps and brown algae." []
subset: 3:STAR
synonym: "algal metabolites" RELATED [chebi]
is_a: CHEBI:75763 ! eukaryotic metabolite
[Term]
id: CHEBI:86327
name: antifungal drug
def: "Any antifungal agent used to prevent or treat fungal infections in humans or animals." []
subset: 3:STAR
synonym: "anti-fungal drug" RELATED [chebi]
synonym: "anti-fungal drugs" RELATED [chebi]
synonym: "anti-fungal medication" RELATED [chebi]
synonym: "anti-fungal medications" RELATED [chebi]
synonym: "antifungal drugs" RELATED [chebi]
synonym: "antifungal medication" RELATED [chebi]
synonym: "antifungal medications" RELATED [chebi]
synonym: "pharmaceutical fungicide" RELATED [chebi]
synonym: "pharmaceutical fungicides" RELATED [chebi]
xref: wikipedia.en:Antifungal {source="wikipedia.en"}
is_a: CHEBI:35441 ! antiinfective agent
is_a: CHEBI:35718 ! antifungal agent
[Term]
id: CHEBI:87518
name: ADP(2-)
def: "An organophosphate oxoanion obtained by deprotonation of two of the three diphosphate OH groups of adenosine 5'-diphosphate." []
subset: 3:STAR
synonym: "5'-O-{[(hydroxyphosphinato)oxy]phosphinato}adenosine" EXACT IUPAC:NAME [IUPAC]
synonym: "5'-O-{[(hydroxyphosphinato)oxy]phosphinato}adenosine" RELATED IUPAC:NAME [iupac]
xref: reaxys:7558006 {source="reaxys"}
is_a: CHEBI:58945 ! organophosphate oxoanion
relationship: RO:0018033 CHEBI:16761 ! is deprotonated form of ADP
relationship: RO:0018034 CHEBI:456216 ! is protonated form of ADP(3-)
[Term]
id: CHEBI:90710
name: receptor modulator
alt_id: CHEBI:189678
def: "A drug that acts as an antagonist, agonist, reverse agonist, or in some other fashion when interacting with cellular receptors." []
subset: 3:STAR
synonym: "receptor modulators" RELATED [chebi]
xref: wikipedia.en:Receptor_modulator {source="wikipedia.en"}
is_a: CHEBI:23888 ! drug
[Term]
id: CHEBI:9937
name: vasopressin
def: "A family of cyclic nonapeptide hormones found in most mammals. Synthesised in the hypothalamus and stored in the post-pituitary, vasopressins play a key rôle in homeostasis, particularly in regulating the body's water content. Together with the similar neuropeptide oxytocin, they are believed to influence social cognition and behaviour." []
subset: 3:STAR
synonym: "ADH" RELATED [kegg.compound]
synonym: "Antidiuretic hormone" RELATED [kegg.compound]
synonym: "arginine vasopressin" RELATED [chebi]
synonym: "argipressin" RELATED [chebi]
synonym: "AVP" RELATED [chebi]
synonym: "beta-Hypophamine" RELATED [chemidplus]
synonym: "Inyectable de vasopresina" RELATED http://purl.obolibrary.org/obo/chebi/INN [chemidplus]
synonym: "Solute injectable de vasopressine" RELATED http://purl.obolibrary.org/obo/chebi/INN [chemidplus]
synonym: "Vasopressin" RELATED [kegg.compound]
synonym: "Vasopressini injectio" RELATED http://purl.obolibrary.org/obo/chebi/INN [chemidplus]
synonym: "VP" RELATED [kegg.compound]
xref: cas:11000-17-2 {source="cas"}
xref: kegg.compound:C00840 {source="kegg.compound"}
xref: kegg.drug:D00101 {source="kegg.drug"}
xref: pubmed:18988842 {source="pubmed"}
xref: pubmed:20445498 {source="pubmed"}
is_a: CHEBI:24533 ! heterodetic cyclic peptide
is_a: CHEBI:25905 ! peptide hormone
[Term]
id: CL:0000000
name: cell
def: "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." [CARO:mah]
comment: The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one).
subset: cellxgene_subset
subset: ubprop:upper_level
xref: CALOHA:TS-2035
xref: FBbt:00007002 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
xref: FMA:68646
xref: GO:0005623
xref: KUPO:0000002
xref: MESH:D002477
xref: VHOG:0001533
xref: WBbt:0004017
xref: XAO:0003012
xref: ZFA:0009000 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: UBERON:0000061 ! anatomical structure
disjoint_from: GO:0031012 ! extracellular matrix
disjoint_from: GO:0032991 ! protein-containing complex
disjoint_from: GO:0043226 ! organelle
disjoint_from: GO:0044423 ! virion component
relationship: has_part GO:0005634 {gci_filler="PATO:0001407", gci_relation="RO:0000053"} ! nucleus
relationship: has_part GO:0005634 {gci_filler="PATO:0001908", gci_relation="RO:0000053"} ! nucleus
relationship: in_taxon NCBITaxon:131567 ! cellular organism
property_value: editor_note "CL and GO definitions of cell differ based on inclusive or exclusive of cell wall, etc." xsd:string
property_value: editor_note "We struggled with this definition. We are worried about circularity. We also considered requiring the capability of metabolism." xsd:string
[Term]
id: CL:0000005
name: neural crest derived fibroblast
def: "Any fibroblast that is derived from the neural crest." [https://orcid.org/0000-0001-5208-3432]
synonym: "fibroblast neural crest derived" EXACT []
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: develops_from CL:0000333 ! migratory neural crest cell
relationship: develops_from CL:0000008 ! migratory cranial neural crest cell
relationship: develops_from CL:0000333 ! migratory neural crest cell
[Term]
id: CL:0000006
name: neuronal receptor cell
def: "Any sensory receptor cell that is a(n) neuron and is capable of some detection of stimulus involved in sensory perception." [FBC:Autogenerated]
subset: cellxgene_subset
synonym: "neuronal receptor cell (sensu Animalia)" EXACT []
xref: ZFA:0009001 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000101 ! sensory neuron
is_a: CL:0000197 ! sensory receptor cell
intersection_of: CL:0000197 ! sensory receptor cell
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
relationship: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
[Term]
id: CL:0000007
name: early embryonic cell (metazoa)
def: "A cell found in the embryo before the formation of all the gem layers is complete." [GOC:tfm]
xref: ZFA:0009002 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0002321 ! embryonic cell (metazoa)
[Term]
id: CL:0000008
name: migratory cranial neural crest cell
def: "Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination." [https://orcid.org/0000-0001-5208-3432, ZFA:0007091]
xref: ZFA:0007091 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000333 ! migratory neural crest cell
[Term]
id: CL:0000011
name: migratory trunk neural crest cell
def: "Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination." [https://orcid.org/0000-0001-5208-3432, ZFA:0007095]
xref: ZFA:0007095 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000333 ! migratory neural crest cell
[Term]
id: CL:0000014
name: germ line stem cell
def: "A stem cell that is the precursor of gametes." [doi:10.1016/j.stem.2012.05.016]
synonym: "germline stem cell" EXACT []
xref: FBbt:00004861 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
xref: ZFA:0005956 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000034 {is_inferred="true"} ! stem cell
is_a: CL:0000039 ! germ line cell
intersection_of: CL:0000039 ! germ line cell
intersection_of: capable_of GO:0017145 ! stem cell division
relationship: capable_of GO:0017145 ! stem cell division
[Term]
id: CL:0000015
name: male germ cell
def: "A germ cell that supports male gamete production. In some species, non-germ cells known as Sertoli cells also play a role in spermatogenesis." [https://orcid.org/0000-0001-5208-3432, PMID:29462262]
subset: cellxgene_subset
xref: FMA:72290
xref: MA:0002765
xref: ncithesaurus:Spermatogenic_Cell
xref: VHOG:0001531
is_a: CL:0000586 {is_inferred="true"} ! germ cell
relationship: capable_of_part_of GO:0007283 ! spermatogenesis
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000015" xsd:string {name="male germ cell on CELLxGENE CellGuide"}
property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/574" xsd:string
[Term]
id: CL:0000017
name: spermatocyte
def: "A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids." [GOC:tfm, MESH:D013090]
subset: cellxgene_subset
xref: BTO:0001275
xref: CALOHA:TS-0951
xref: EMAPA:31484
xref: FBbt:00004936 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
xref: FMA:84049
xref: WBbt:0006799
xref: ZFA:0009005 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000015 ! male germ cell
intersection_of: CL:0000015 ! male germ cell
intersection_of: capable_of GO:0048137 ! spermatocyte division
relationship: capable_of GO:0048137 ! spermatocyte division
relationship: develops_from CL:0000020 ! spermatogonium
[Term]
id: CL:0000018
name: spermatid
def: "A male germ cell that develops from the haploid secondary spermatocytes. Without further division, spermatids undergo structural changes and give rise to spermatozoa." [MESH:D013087]
subset: cellxgene_subset
synonym: "nematoblast" EXACT []
xref: BTO:0001274
xref: CALOHA:TS-0950
xref: EMAPA:31486
xref: FBbt:00004942 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
xref: FMA:72294
xref: WBbt:0006800
xref: ZFA:0005769 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000015 ! male germ cell
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000413 ! haploid cell
intersection_of: CL:0000015 ! male germ cell
intersection_of: capable_of GO:0001675 ! acrosome assembly
intersection_of: capable_of GO:0007288 ! sperm axoneme assembly
intersection_of: capable_of GO:0007289 ! spermatid nucleus differentiation
intersection_of: RO:0000053 PATO:0001375 ! has characteristic haploid
relationship: capable_of GO:0001675 ! acrosome assembly
relationship: capable_of GO:0007288 ! sperm axoneme assembly
relationship: capable_of GO:0007289 ! spermatid nucleus differentiation
relationship: develops_from CL:0000657 ! secondary spermatocyte
relationship: RO:0000053 PATO:0001375 ! has characteristic haploid
[Term]
id: CL:0000019
name: sperm
def: "A mature male germ cell that develops from a spermatid." [GOC:tfm, MESH:D013094]
synonym: "sperm cell" EXACT []
synonym: "spermatozoid" EXACT []
synonym: "spermatozoon" EXACT []
xref: BTO:0001277
xref: BTO:0002046
xref: CALOHA:TS-0949
xref: FBbt:00004954 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
xref: FMA:67338
xref: WBbt:0006798
xref: ZFA:0009006 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000408 {is_inferred="true"} ! male gamete
relationship: develops_from CL:0000018 ! spermatid
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000019" xsd:string {name="sperm on CELLxGENE CellGuide"}
[Term]
id: CL:0000020
name: spermatogonium
def: "An euploid male germ cell of an early stage of spermatogenesis." [MESH:D013093]
subset: cellxgene_subset
synonym: "spermatogonial cell" EXACT []
xref: BTO:0000958
xref: CALOHA:TS-2193
xref: EMAPA:31482
xref: FBbt:00004934 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
xref: FBbt:00004935 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
xref: FMA:72291
xref: ZFA:0009007 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000015 ! male germ cell
intersection_of: CL:0000015 ! male germ cell
intersection_of: RO:0000053 PATO:0001394 ! has characteristic diploid
intersection_of: RO:0000053 PATO:0001501 ! has characteristic immature
relationship: RO:0000053 PATO:0001394 ! has characteristic diploid
relationship: RO:0000053 PATO:0001501 ! has characteristic immature
[Term]
id: CL:0000021
name: female germ cell
def: "Female germ cell is a germ cell that supports female gamete production." [GOC:tfm, PMID:11023867, PMID:20454446]
subset: cellxgene_subset
xref: MA:0000388
xref: ncithesaurus:Egg
xref: VHOG:0001530
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000586 {is_inferred="true"} ! germ cell
intersection_of: CL:0000586 ! germ cell
intersection_of: capable_of GO:0048477 ! oogenesis
relationship: capable_of GO:0048477 ! oogenesis
[Term]
id: CL:0000022
name: female germ line stem cell
def: "A stem cell that is the precursor of female gametes." [doi:10.1016/j.stem.2012.05.016]
xref: FBbt:00004873 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
is_a: CL:0000014 {is_inferred="true"} ! germ line stem cell
is_a: CL:0000021 {is_inferred="true"} ! female germ cell
intersection_of: CL:0000021 ! female germ cell
intersection_of: capable_of GO:0017145 ! stem cell division
relationship: capable_of GO:0017145 ! stem cell division
[Term]
id: CL:0000023
name: oocyte
def: "A female germ cell that has entered meiosis." [GOC:tfm, ISBN:0721662544]
subset: cellxgene_subset
synonym: "oogonium" RELATED []
xref: BTO:0000964
xref: CALOHA:TS-0711
xref: FBbt:00004886 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
xref: FMA:18644
xref: MESH:D009865
xref: WBbt:0006797
xref: ZFA:0001109 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000021 {is_inferred="true"} ! female germ cell
relationship: participates_in GO:0007143 ! female meiotic nuclear division
[Term]
id: CL:0000024
name: oogonial cell
def: "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes." [GOC:tfm, ISBN:0721662544]
subset: cellxgene_subset
xref: FMA:83673
xref: ZFA:0005878 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000021 {is_inferred="true"} ! female germ cell
intersection_of: CL:0000021 ! female germ cell
intersection_of: capable_of GO:0000278 ! mitotic cell cycle
relationship: capable_of GO:0000278 ! mitotic cell cycle
relationship: develops_from CL:0000670 ! primordial germ cell
[Term]
id: CL:0000025
name: egg cell
def: "A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization." [GOC:tfm, ISBN:0721662544]
synonym: "mature oocyte" EXACT []
synonym: "ovum" EXACT []
xref: BTO:0000369
xref: BTO:0003801
xref: CALOHA:TS-2191
xref: FBbt:00057012 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
xref: FMA:67343
xref: MESH:D010063
xref: ZFA:0001570 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000675 {is_inferred="true"} ! female gamete
relationship: develops_from CL:0000023 ! oocyte
relationship: participates_in GO:0007143 ! female meiotic nuclear division
property_value: depiction "https://www.swissbiopics.org/api/image/Egg_cell.svg" xsd:anyURI
[Term]
id: CL:0000027
name: smooth muscle cell neural crest derived
def: "A smooth muscle cell derived from the neural crest." [https://orcid.org/0000-0001-5208-3432]
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: develops_from CL:0000333 ! migratory neural crest cell
relationship: develops_from CL:0000008 ! migratory cranial neural crest cell
relationship: develops_from CL:0000333 ! migratory neural crest cell
[Term]
id: CL:0000029
name: neural crest derived neuron
def: "Any neuron that develops from some migratory neural crest cell." [FBC:Autogenerated]
subset: cellxgene_subset
synonym: "neuron neural crest derived" EXACT []
xref: ZFA:0009009 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000540 {is_inferred="true"} ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: develops_from CL:0000333 ! migratory neural crest cell
relationship: develops_from CL:0000333 ! migratory neural crest cell
relationship: develops_from CL:0002676 ! neural crest derived neuroblast
[Term]
id: CL:0000030
name: glioblast
def: "A non-terminally differentiated cell that develops form the neuroectoderm. Glioblast has the potential to differentiate into various types of glial cells, including astrocytes and oligodendrocytes." [PMID:37824650, Wikipedia:Glioblast]
subset: cellxgene_subset
xref: ZFA:0009010 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0011026 ! progenitor cell
relationship: develops_from CL:0000133 ! neurectodermal cell
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000030" xsd:string {name="glioblast on CELLxGENE CellGuide"}
[Term]
id: CL:0000031
name: neuroblast (sensu Vertebrata)
def: "A cell that will develop into a neuron often after a migration phase." [GOC:NV, http://en.wikipedia.org/wiki/Neuroblast]
subset: cellxgene_subset
synonym: "neuroblast" EXACT []
xref: BTO:0000930
xref: FMA:70563
xref: ZFA:0009011 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0011026 ! progenitor cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
[Term]
id: CL:0000034
name: stem cell
def: "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:tfm, MESH:D013234]
comment: This term applies to metazoan. For plant stem cells, consider using PO:0004011 ‘initial cell’ or its parent PO:0004010 ‘meristematic cell’.
subset: cellxgene_subset
subset: general_cell_types_upper_slim
subset: human_reference_atlas
synonym: "animal stem cell" EXACT []
xref: CALOHA:TS-2086
xref: FMA:63368
xref: ZFA:0005957 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0011115 ! precursor cell
intersection_of: CL:0000000 ! cell
intersection_of: capable_of GO:0017145 ! stem cell division
relationship: capable_of GO:0017145 ! stem cell division
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000034" xsd:string {name="stem cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000035
name: single fate stem cell
def: "A stem cell that self-renews as well as give rise to a single mature cell type." [GOC:tfm]
synonym: "unipotent stem cell" EXACT []
synonym: "unipotential stem cell" EXACT []
xref: FMA:70569
xref: ZFA:0009013 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000723 ! somatic stem cell
intersection_of: CL:0000000 ! cell
intersection_of: capable_of GO:0017145 ! stem cell division
intersection_of: RO:0000053 PATO:0001400 ! has characteristic unipotent
relationship: capable_of GO:0017145 ! stem cell division
relationship: RO:0000053 PATO:0001400 ! has characteristic unipotent
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000035" xsd:string {name="single fate stem cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000036
name: epithelial fate stem cell
def: "A somatic stem cell that is committed to an epithelial fate, possessing the capacity for self-renewal and the ability to differentiate into one or more distinct mature cell types of the epithelial lineage. This cell is crucial for the development, homeostasis, repair, and regeneration of epithelial tissues." [doi:/10.1038/sj.eye.6700575, PMID:17289566]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "epithelial stem cell" EXACT []
is_a: CL:0000723 ! somatic stem cell
intersection_of: CL:0000723 ! somatic stem cell
intersection_of: capable_of GO:0030855 ! epithelial cell differentiation
relationship: capable_of GO:0030855 ! epithelial cell differentiation
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000036" xsd:string {name="epithelial fate stem cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000037
name: hematopoietic stem cell
def: "A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Hematopoietic_stem_cell, PMID:19022770]
comment: Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative.
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "blood forming stem cell" EXACT []
synonym: "colony forming unit hematopoietic" RELATED []
synonym: "hemopoietic stem cell" EXACT []
synonym: "HSC" RELATED OMO:0003000 []
xref: BTO:0000725
xref: CALOHA:TS-0448
xref: FMA:86475
xref: MESH:D006412
xref: VHOG:0001485
xref: ZFA:0009014 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000723 ! somatic stem cell
is_a: CL:0008001 ! hematopoietic precursor cell
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: capable_of GO:0002244 ! hematopoietic progenitor cell differentiation
intersection_of: capable_of GO:0048103 ! somatic stem cell division
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
relationship: capable_of GO:0002244 ! hematopoietic progenitor cell differentiation
relationship: capable_of GO:0048103 ! somatic stem cell division
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
relationship: develops_from CL:0000566 ! angioblastic mesenchymal cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000037" xsd:string {name="hematopoietic stem cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000038
name: erythroid progenitor cell
def: "A progenitor cell committed to the erythroid lineage." [GOC:add, ISBN:0721601464]
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
synonym: "BFU-E" RELATED OMO:0003000 []
synonym: "blast forming unit erythroid" RELATED []
synonym: "burst forming unit erythroid" RELATED []
synonym: "CFU-E" RELATED OMO:0003000 []
synonym: "colony forming unit erythroid" RELATED []
synonym: "erythroid stem cell" RELATED []
xref: BTO:0004911
xref: ZFA:0009015 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000764 ! erythroid lineage cell
is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell
relationship: develops_from CL:0000050 ! megakaryocyte-erythroid progenitor cell
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000038" xsd:string {name="erythroid progenitor cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000039
name: germ line cell
def: "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring." [GOC:tfm, ISBN:0721662544]
comment: Originally this term had some plant germ line cell children.
subset: general_cell_types_upper_slim
subset: ubprop:upper_level
xref: ZFA:0009016 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000000 ! cell
relationship: capable_of GO:0022414 ! reproductive process
[Term]
id: CL:0000040
name: monoblast
def: "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus." [GOC:add, http://en.wikipedia.org/wiki/Monoblast, http://www.copewithcytokines.de, PMID:1104740]
comment: Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid.
synonym: "CFU-M" RELATED OMO:0003000 []
synonym: "colony forming unit macrophage" RELATED []
synonym: "colony forming unit monocyte" RELATED []
synonym: "monocyte stem cell" RELATED []
xref: CALOHA:TS-1195
xref: FMA:83553
xref: ZFA:0009017 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002194 {is_inferred="true"} ! monopoietic cell
intersection_of: CL:0002194 ! monopoietic cell
intersection_of: capable_of GO:0030224 ! monocyte differentiation
intersection_of: has_part CL:0017503 ! basophilic cytoplasm
intersection_of: has_part GO:0000791 ! euchromatin
intersection_of: has_part GO:0005730 ! nucleolus
intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
relationship: capable_of GO:0030224 ! monocyte differentiation
relationship: develops_from CL:0002009 ! macrophage dendritic cell progenitor
relationship: has_part CL:0017503 ! basophilic cytoplasm
relationship: has_part GO:0000791 ! euchromatin
relationship: has_part GO:0005730 ! nucleolus
relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
[Term]
id: CL:0000047
name: neural stem cell
def: "An undifferentiated neural cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple central nervous system neuronal and glial cell types." [PMID:30639325]
subset: cellxgene_subset
synonym: "neuronal stem cell" EXACT [PMID:16305818]
synonym: "NSC" EXACT []
xref: BTO:0002881
xref: CALOHA:TS-2360
xref: FMA:86684
xref: ZFA:0009019 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0002319 ! neural cell
relationship: develops_from CL:0000133 ! neurectodermal cell
[Term]
id: CL:0000048
name: multi fate stem cell
def: "A stem cell that can give rise to multiple lineages of cells." [GOC:add]
synonym: "multi-fate stem cell" EXACT []
synonym: "multifate stem cell" EXACT []
synonym: "multipotent cell" EXACT []
synonym: "multipotent stem cell" EXACT []
xref: FMA:84789
xref: ZFA:0009020 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000034 ! stem cell
intersection_of: CL:0000000 ! cell
intersection_of: capable_of GO:0017145 ! stem cell division
intersection_of: RO:0000053 PATO:0001402 ! has characteristic multipotent
relationship: capable_of GO:0017145 ! stem cell division
relationship: RO:0000053 PATO:0001402 ! has characteristic multipotent
[Term]
id: CL:0000049
name: common myeloid progenitor
def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." [GOC:add, ISBN:0878932437, MESH:D023461]
comment: This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059).
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "CFU-GEMM" RELATED OMO:0003000 [ISBN:0878932437]
synonym: "CFU-S" RELATED OMO:0003000 [ISBN:0878932437]
synonym: "CMP" RELATED OMO:0003000 [ISBN:0878932437]
synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437]
synonym: "common myeloid precursor" EXACT []
synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437]
synonym: "myeloid stem cell" RELATED [ISBN:0878932437]
synonym: "pluripotent stem cell (bone marrow)" RELATED [ISBN:0878932437]
xref: BTO:0004730
xref: ZFA:0009021 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell
disjoint_from: CL:0000050 ! megakaryocyte-erythroid progenitor cell
disjoint_from: CL:0000051 ! common lymphoid progenitor
disjoint_from: CL:0000557 ! granulocyte monocyte progenitor cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000049" xsd:string {name="common myeloid progenitor on CELLxGENE CellGuide"}
[Term]
id: CL:0000050
name: megakaryocyte-erythroid progenitor cell
def: "A progenitor cell committed to the megakaryocyte and erythroid lineages." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Megakaryocyte-erythroid_progenitor_cell, MESH:D055015, PMID:16647566]
comment: MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "CFU-EM" EXACT []
synonym: "CFU-MegE" EXACT []
synonym: "colony forming unit erythroid megakaryocyte" EXACT []
synonym: "Meg/E progenitor" EXACT []
synonym: "megakaryocyte/erythrocyte progenitor" EXACT []
synonym: "megakaryocyte/erythroid progenitor cell" EXACT []
synonym: "MEP" EXACT []
xref: ZFA:0009022 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: capable_of GO:0030218 ! erythrocyte differentiation
intersection_of: capable_of GO:0030219 ! megakaryocyte differentiation
disjoint_from: CL:0000557 ! granulocyte monocyte progenitor cell
disjoint_from: CL:0002009 ! macrophage dendritic cell progenitor
relationship: capable_of GO:0030218 ! erythrocyte differentiation
relationship: capable_of GO:0030219 ! megakaryocyte differentiation
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000050" xsd:string {name="megakaryocyte-erythroid progenitor cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000051
name: common lymphoid progenitor
def: "A oligopotent progenitor cell committed to the lymphoid lineage." [GOC:add, GOC:dsd, GOC:tfm, PMID:10407577, PMID:16551251]
comment: CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "CLP" RELATED OMO:0003000 []
synonym: "committed lymphopoietic stem cell" RELATED []
synonym: "common lymphocyte precursor" EXACT []
synonym: "common lymphocyte progenitor" EXACT []
synonym: "common lymphoid precursor" EXACT []
synonym: "early lymphocyte progenitor" RELATED []
synonym: "ELP" RELATED OMO:0003000 []
synonym: "lymphoid stem cell" RELATED []
synonym: "lymphopoietic stem cell" RELATED []
xref: ZFA:0009023 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: capable_of GO:0030098 ! lymphocyte differentiation
relationship: capable_of GO:0030098 ! lymphocyte differentiation
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000051" xsd:string {name="common lymphoid progenitor on CELLxGENE CellGuide"}
[Term]
id: CL:0000052
name: totipotent stem cell
def: "A stem cell from which all cells of the body can form." [GOC:add, GOC:tfm]
synonym: "totipotential stem cell" EXACT []
xref: FMA:84790
xref: MESH:D039901
xref: ZFA:0009024 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000723 ! somatic stem cell
[Term]
id: CL:0000056
name: myoblast
def: "A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair." [GOC:tfm, MESH:D032446, PMID:21849021]
subset: cellxgene_subset
xref: BTO:0000222
xref: CALOHA:TS-0650
xref: FBbt:00005083 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
xref: FMA:70335
xref: VHOG:0001529
xref: ZFA:0009025 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000680 ! muscle precursor cell
[Term]
id: CL:0000057
name: fibroblast
def: "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." [http://en.wikipedia.org/wiki/Fibroblast, ISBN:0517223651, MESH:D005347]
comment: These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative.
subset: cellxgene_subset
subset: human_reference_atlas
xref: BTO:0000452
xref: CALOHA:TS-0362
xref: FMA:63877
xref: NCIT:C12482
xref: VHOG:0001482
xref: ZFA:0009026 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000499 ! stromal cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000058
name: chondroblast
def: "Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell." [GO_REF:0000034, GOC:tfm, ISBN:0618947256]
subset: cellxgene_subset
synonym: "chrondoplast" EXACT []
xref: BTO:0003607
xref: FMA:66783
xref: ZFA:0009027 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0002320 ! connective tissue cell
is_a: CL:0011026 ! progenitor cell
relationship: develops_from CL:0007009 ! prechondroblast
relationship: produces UBERON:0002418 ! cartilage tissue
[Term]
id: CL:0000059
name: ameloblast
def: "Skeletogenic cell that produces enamel, overlies the odontogenic papilla, and arises from the differentiation of a preameloblast cell." [GO_REF:0000034, GOC:tfm, MESH:D000565]
comment: non-encoded relationship from VSAO produces VSAO:0000066
synonym: "amelocyte" EXACT []
synonym: "enamel secreting cell" EXACT []
xref: BTO:0001663
xref: FMA:70576
is_a: CL:0000146 ! simple columnar epithelial cell
is_a: CL:0002077 ! ecto-epithelial cell
is_a: CL:1100001 ! secretory epithelial cell
relationship: adjacent_to UBERON:0001763 ! odontogenic papilla
relationship: capable_of GO:0097186 ! amelogenesis
relationship: develops_from CL:0007000 ! preameloblast
relationship: part_of UBERON:0005176 ! tooth enamel organ
relationship: produces UBERON:0001752 ! enamel
[Term]
id: CL:0000060
name: odontoblast
def: "Skeletogenic cell that secretes dentine matrix, is derived from the odontogenic papilla, and develops from a preodontoblast cell." [GO_REF:0000034, ISBN:0618947256]
comment: legacy def: One of the cells forming the outer surface of dental pulp that produces tooth dentin.
subset: cellxgene_subset
xref: BTO:0001769
xref: CALOHA:TS-0696
xref: FMA:62999
xref: MESH:D009804
xref: ZFA:0009029 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:0002148 ! dental pulp cell
relationship: develops_from CL:0007003 ! preodontoblast
relationship: part_of UBERON:0005176 ! tooth enamel organ
relationship: produces UBERON:0001751 ! dentine
[Term]
id: CL:0000062
name: osteoblast
def: "Skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell." [GO_REF:0000034, MESH:D010006]
comment: non-encoded relationships from VSAO - capable_of_producing VSAO:0000020
subset: cellxgene_subset
xref: BTO:0001593
xref: CALOHA:TS-0720
xref: FMA:66780
xref: ZFA:0009031 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0002320 ! connective tissue cell
relationship: develops_from CL:0007010 ! preosteoblast
relationship: produces UBERON:0008883 ! osteoid
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000062" xsd:string {name="osteoblast on CELLxGENE CellGuide"}
[Term]
id: CL:0000064
name: ciliated cell
def: "A cell that has a filiform extrusion of the cell surface." [GOC:tfm]
subset: cellxgene_subset
xref: VHOG:0001532
xref: XAO:0000031
xref: ZFA:0009032 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: has_part GO:0005929 ! cilium
relationship: has_part GO:0005929 ! cilium
[Term]
id: CL:0000065
name: ependymal cell
def: "A neuroepithelial glial cell, derived from a radial glial cell originating from the neuroectoderm, lines the ventricles of the brain and the central canal of the spinal cord. This cell is characterized by the presence of cilia on its apical surface, which can be motile or non-motile." [doi:/10.3389/fncel.2021.703951, GOC:tfm, https://www.britannica.com/science/ependymal-cell, JB:jb, PMID:34335193, PMID:37008045, PMID:9550134]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "ependymocyte" NARROW [doi:10.53347/rID-51713]
xref: BTO:0001724
xref: FMA:70550
xref: ZFA:0009033 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000067 ! ciliated epithelial cell
is_a: CL:0000125 ! glial cell
is_a: CL:0000710 ! neurecto-epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0004670 ! ependyma
relationship: develops_from CL:0000681 ! radial glial cell
relationship: develops_from UBERON:0001016 ! nervous system
relationship: directly_develops_from CL:0000681 ! radial glial cell
relationship: part_of UBERON:0004670 ! ependyma
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000065" xsd:string {name="ependymal cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000066
name: epithelial cell
def: "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina." [FB:ma, GOC:tfm, MESH:D004847]
subset: cellxgene_subset
subset: general_cell_types_upper_slim
subset: human_reference_atlas
synonym: "epitheliocyte" EXACT []
xref: BTO:0000414
xref: CALOHA:TS-2026
xref: CARO:0000077
xref: FBbt:00000124 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
xref: FMA:66768
xref: WBbt:0003672
xref: ZFA:0009034 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000255 ! eukaryotic cell
disjoint_from: CL:0000738 ! leukocyte
relationship: part_of UBERON:0000483 ! epithelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: depiction "https://www.swissbiopics.org/api/image/Epithelial_cells.svg" xsd:anyURI
[Term]
id: CL:0000067
name: ciliated epithelial cell
def: "An epithelial cell that has a cilia." [GOC:tfm]
subset: cellxgene_subset
xref: FMA:70605
xref: ZFA:0009035 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000064 ! ciliated cell
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: has_part GO:0005929 ! cilium
relationship: has_part GO:0005929 ! cilium
[Term]
id: CL:0000068
name: duct epithelial cell
def: "An epithelial cell that is part of a duct." [https://orcid.org/0000-0001-5208-3432]
subset: cellxgene_subset
xref: ZFA:0009372 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0000058 ! duct
relationship: part_of UBERON:0000058 ! duct
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000068" xsd:string {name="duct epithelial cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000069
name: branched duct epithelial cell
is_a: CL:0000068 ! duct epithelial cell
[Term]
id: CL:0000071
name: blood vessel endothelial cell
def: "An endothelial cell that lines the vasculature." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
xref: ZFA:0009036 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0002139 ! endothelial cell of vascular tree
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0001981 ! blood vessel
relationship: part_of UBERON:0001981 ! blood vessel
relationship: part_of UBERON:0004638 ! blood vessel endothelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000071" xsd:string {name="blood vessel endothelial cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000072
name: non-branched duct epithelial cell
is_a: CL:0000068 ! duct epithelial cell
is_a: CL:0002078 ! meso-epithelial cell
[Term]
id: CL:0000075
name: columnar/cuboidal epithelial cell
def: "A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GO:0002065, https://orcid.org/0000-0001-5208-3432]
subset: cellxgene_subset
subset: human_reference_atlas
xref: ZFA:0009038 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000066 ! epithelial cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000076
name: squamous epithelial cell
subset: cellxgene_subset
xref: CALOHA:TS-1249
xref: ZFA:0009039 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000066 ! epithelial cell
[Term]
id: CL:0000077
name: mesothelial cell
def: "A flat, squamous-like epithelial cell of mesodermal origin. It forms the mesothelium, which lines the body's serous cavities including the pleural, peritoneal, and pericardial spaces. This cell plays a crucial role in synthesizing and secreting lubricants, such as glycosaminoglycans and surfactants, which minimize friction between adjacent tissues during movement." [GOC:tfm, ISBN:0721662544, PMID:26106328]
comment: Mesothelial cells, which morphologically resemble squamous epithelial cells, express both epithelial markers (cytokeratins) and mesenchymal markers (vimentin), reflecting their mesodermal origin. They feature surface microvilli and apical-basal polarity. Under certain conditions, they can undergo mesothelial-to-mesenchymal transition. These cells also produce extracellular matrix proteins, maintain serosal homeostasis, and facilitate fluid transport. {xref="PMID:26106328"}
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "mesotheliocyte" EXACT []
xref: FMA:66773
xref: ZFA:0009040 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0002078 ! meso-epithelial cell
relationship: part_of UBERON:0001136 ! mesothelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000077" xsd:string {name="mesothelial cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000078
name: peridermal cell
def: "Any squamous epithelial cell that is part of some periderm." [FBC:Autogenerated]
subset: cellxgene_subset
xref: ZFA:0009041 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0000362 ! epidermal cell
intersection_of: CL:0000076 ! squamous epithelial cell
intersection_of: part_of UBERON:0003055 ! periderm
relationship: part_of UBERON:0003055 ! periderm
[Term]
id: CL:0000079
name: stratified epithelial cell
def: "An epithelial cell, organized into multiple layers, with only the basal layer being in contact with the basement membrane." [doi:/10.1016/B978-0-12-410424-2.00003-2, https://www.biologyonline.com/dictionary/stratified-epithelium, Wikipedia:Epithelium]
subset: cellxgene_subset
xref: ZFA:0009042 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000066 ! epithelial cell
relationship: develops_from CL:0000357 ! stratified epithelial stem cell
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000079" xsd:string {name="stratified epithelial cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000080
name: circulating cell
def: "A cell which moves among different tissues of the body, via blood, lymph, or other medium." [GOC:add]
xref: ZFA:0009043 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0000179 ! haemolymphatic fluid
relationship: part_of UBERON:0000179 ! haemolymphatic fluid
[Term]
id: CL:0000081
name: blood cell
def: "A cell found predominately in the blood." [GOC:add, GOC:tfm]
subset: cellxgene_subset
xref: FMA:62844
xref: MESH:D001773
xref: ZFA:0009044 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: capable_of GO:0008015 ! blood circulation
relationship: capable_of GO:0008015 ! blood circulation
[Term]
id: CL:0000082
name: epithelial cell of lung
def: "An epithelial cell of the lung." [https://orcid.org/0000-0001-5208-3432]
subset: cellxgene_subset
synonym: "lung epithelial cell" EXACT []
xref: BTO:0004299
is_a: CL:0002632 ! epithelial cell of lower respiratory tract
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0000115 ! lung epithelium
relationship: part_of UBERON:0000115 ! lung epithelium
[Term]
id: CL:0000083
name: epithelial cell of pancreas
def: "An epithelial cell of the pancreas." [GOC:tfm]
subset: cellxgene_subset
synonym: "pancreas epithelial cell" EXACT []
synonym: "pancreatic epithelial cell" EXACT []
xref: BTO:0000028
xref: ZFA:0009045 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0002076 ! endo-epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001264 ! pancreas
relationship: part_of UBERON:0001264 ! pancreas
[Term]
id: CL:0000084
name: T cell
def: "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [GOC:add, GOC:tfm, ISBN:0781735149]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "immature T cell" RELATED []
synonym: "mature T cell" RELATED []
synonym: "T lymphocyte" EXACT []
synonym: "T-cell" EXACT []
synonym: "T-lymphocyte" EXACT []
xref: BTO:0000782
xref: CALOHA:TS-1001
xref: FMA:62870
xref: MESH:D013601
xref: VHOG:0001479
xref: ZFA:0009046 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000542 {is_inferred="true"} ! lymphocyte
intersection_of: CL:0000542 ! lymphocyte
intersection_of: capable_of GO:0002456 ! T cell mediated immunity
disjoint_from: CL:0000945 ! lymphocyte of B lineage
relationship: capable_of GO:0002456 ! T cell mediated immunity
relationship: develops_from CL:0000827 ! pro-T cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000092
name: osteoclast
def: "A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149, PMID:10428500, PMID:15055519, PMID:17380158]
comment: Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid.
subset: cellxgene_subset
synonym: "chondroclast" RELATED []
xref: BTO:0000968
xref: CALOHA:TS-0721
xref: FMA:66781
xref: MESH:D010010
xref: ZFA:0009047 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000518 ! phagocyte (sensu Vertebrata)
is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte
is_a: CL:0001035 {is_inferred="true"} ! bone cell
intersection_of: CL:0000766 ! myeloid leukocyte
intersection_of: capable_of GO:0045453 ! bone resorption
intersection_of: has_part PR:000001850 ! cathepsin K
intersection_of: has_part PR:000001937 ! tartrate-resistant acid phosphatase type 5
intersection_of: has_part PR:000001944 ! transcription factor PU.1
intersection_of: has_part PR:000007597 ! protein c-Fos
intersection_of: has_part PR:000011178 ! nuclear factor NF-kappa-B p100 subunit
intersection_of: part_of UBERON:0001474 ! bone element
intersection_of: RO:0002104 PR:000001954 ! has plasma membrane part tumor necrosis factor receptor superfamily member 11A
intersection_of: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor
relationship: capable_of GO:0045453 ! bone resorption
relationship: develops_from CL:0000576 ! monocyte
relationship: has_part PR:000001850 ! cathepsin K
relationship: has_part PR:000001937 ! tartrate-resistant acid phosphatase type 5
relationship: has_part PR:000001944 ! transcription factor PU.1
relationship: has_part PR:000007597 ! protein c-Fos
relationship: has_part PR:000011178 ! nuclear factor NF-kappa-B p100 subunit
relationship: part_of UBERON:0001474 ! bone element
relationship: RO:0002104 PR:000001954 ! has plasma membrane part tumor necrosis factor receptor superfamily member 11A
relationship: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000092" xsd:string {name="osteoclast on CELLxGENE CellGuide"}
[Term]
id: CL:0000094
name: granulocyte
def: "A leukocyte with abundant granules in the cytoplasm." [GOC:amm, GOC:tfm, http://en.wikipedia.org/wiki/Granulocyte, MESH:D006098]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "granular leucocyte" EXACT []
synonym: "granular leukocyte" EXACT []
synonym: "polymorphonuclear leukocyte" EXACT []
xref: BTO:0000539
xref: BTO:0001026
xref: CALOHA:TS-0422
xref: FMA:62854
xref: ZFA:0009048 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000081 ! blood cell
is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte
intersection_of: CL:0000766 ! myeloid leukocyte
intersection_of: capable_of GO:0008015 ! blood circulation
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: has_part GO:0030141 ! secretory granule
intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
intersection_of: RO:0002104 PR:000001332 ! has plasma membrane part cell adhesion molecule CEACAM8
intersection_of: RO:0002104 PR:000001969 ! has plasma membrane part urokinase plasminogen activator surface receptor
relationship: capable_of GO:0008015 ! blood circulation
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: has_part GO:0030141 ! secretory granule
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
relationship: RO:0002104 PR:000001332 ! has plasma membrane part cell adhesion molecule CEACAM8
relationship: RO:0002104 PR:000001969 ! has plasma membrane part urokinase plasminogen activator surface receptor
[Term]
id: CL:0000095
name: neuron associated cell
subset: cellxgene_subset
is_a: CL:0002319 ! neural cell
relationship: develops_from CL:0000133 ! neurectodermal cell
[Term]
id: CL:0000098
name: sensory epithelial cell
def: "A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells." [GOC:tfm, ISBN:0517223651, ISBN:0721662544]
comment: The term "neuroepithelial cell" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710).
synonym: "neuroepithelial cell" BROAD []
xref: BTO:0004301
xref: ZFA:0009050 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000197 ! sensory receptor cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
relationship: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
[Term]
id: CL:0000099
name: interneuron
def: "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions." [GOC:tfm, MESH:D007395]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "CNS interneuron" RELATED []
xref: BTO:0003811
xref: FBbt:00005125 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
xref: FMA:67313
xref: WBbt:0005113
xref: ZFA:0009051 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:2000029 ! central nervous system neuron
relationship: part_of UBERON:0001017 ! central nervous system
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000100
name: motor neuron
def: "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement." [MESH:D009046, PMID:16875686]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "motoneuron" EXACT []
xref: BTO:0000312
xref: FBbt:00005123 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
xref: FMA:83617
xref: WBbt:0005409
xref: ZFA:0009052 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000527 ! efferent neuron
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000100" xsd:string {name="motor neuron on CELLxGENE CellGuide"}
[Term]
id: CL:0000101
name: sensory neuron
def: "Any neuron having a sensory function; an afferent neuron conveying sensory impulses." [ISBN:0721662544]
subset: cellxgene_subset
subset: human_reference_atlas
xref: BTO:0001037
xref: FBbt:00005124 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
xref: FMA:84649
xref: MESH:D011984
xref: WBbt:0005759
xref: ZFA:0009053 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000526 ! afferent neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
relationship: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000107
name: autonomic neuron
def: "A neuron whose cell body is within an autonomic ganglion." [GOC:tfm]
xref: FMA:80121
xref: ZFA:0009059 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:2000032 ! peripheral nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0002410 ! has soma location autonomic nervous system
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: RO:0002100 UBERON:0002410 ! has soma location autonomic nervous system
[Term]
id: CL:0000108
name: cholinergic neuron
def: "A neuron that uses acetylcholine as a vesicular neurotransmitter." [GOC:tfm]
subset: human_reference_atlas
xref: BTO:0004902
xref: FBbt:00007173 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
xref: FMA:84796
xref: MESH:D059329
xref: WBbt:0006840
xref: ZFA:0009060 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000151 ! secretory cell
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0014055 ! acetylcholine secretion, neurotransmission
relationship: capable_of GO:0014055 ! acetylcholine secretion, neurotransmission
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000113
name: mononuclear phagocyte
def: "A vertebrate phagocyte with a single nucleus." [GOC:add, GOC:tfm, ISBN:0781735149]
subset: cellxgene_subset
subset: human_reference_atlas
xref: BTO:0001433
xref: ZFA:0009064 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000518 {is_inferred="true"} ! phagocyte (sensu Vertebrata)
is_a: CL:0000842 ! mononuclear leukocyte
intersection_of: CL:0000518 ! phagocyte (sensu Vertebrata)
intersection_of: RO:0000053 PATO:0001407 ! has characteristic mononucleate
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0000053 PATO:0001407 ! has characteristic mononucleate
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000113" xsd:string {name="mononuclear phagocyte on CELLxGENE CellGuide"}
[Term]
id: CL:0000114
name: surface ectodermal cell
def: "An ectodermal cell that is part of the external ectoderm, forming the outermost layer of the developing embryo. It is characterized by its polarized nature, with distinct apical and basal surfaces (Ferrante Jr., Reinke, & Stanley, 1995). Surface ectodermal cell gives rise to the epidermis, hair follicles, nails, sensory organs, and specialized structures like the apical ectodermal ridge crucial for limb development (Skoufa et al., 2024)." [doi:/10.1101/2024.07.02.601324, PMID:7892198, Wikipedia:Surface_ectoderm]
synonym: "cell of surface ectoderm" EXACT []
synonym: "surface ectoderm cell" EXACT [doi:/10.1101/2024.07.02.601324]
xref: FMA:72552
is_a: CL:0000221 ! ectodermal cell
intersection_of: CL:0000221 ! ectodermal cell
intersection_of: part_of UBERON:0000076 ! external ectoderm
relationship: part_of UBERON:0000076 ! external ectoderm
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000114" xsd:string {name="surface ectodermal cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000115
name: endothelial cell
def: "An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm." [GOC:tfm, http://en.wikipedia.org/wiki/Endothelial_cell, https://sourceforge.net/tracker/?func=detail&atid=440764&aid=3364936&group_id=36855, MESH:D042783, PMID:21275341]
comment: From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard].
subset: cellxgene_subset
subset: general_cell_types_upper_slim
subset: human_reference_atlas
synonym: "endotheliocyte" EXACT []
xref: BTO:0001176
xref: CALOHA:TS-0278
xref: FMA:66772
xref: ZFA:0009065 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000255 ! eukaryotic cell
relationship: develops_from CL:0000222 ! mesodermal cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000118
name: basket cell
def: "Basket cells are inhibitory GABAergic interneurons of the brain. In general, dendrites of basket cells are free branching and contain smooth spines. Axons are highly branched. The branched axonal arborizations give rise to basket-like structures that surround the soma of the target cell. Basket cells form axo-somatic synapses, meaning their synapses target somas of other cells." [WikipediaVersioned:Basket_cell&oldid=951703880]
subset: BDS_subset
xref: ZFA:0009068 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0011005 ! GABAergic interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission
intersection_of: RO:0000053 PATO:0070002 ! has characteristic basket cell morphology
relationship: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: RO:0000053 PATO:0070002 ! has characteristic basket cell morphology
[Term]
id: CL:0000119
name: cerebellar Golgi cell
def: "Large intrinsic neuron located in the granule layer of the cerebellar cortex that extends its dendrites into the molecular layer where they receive contact from parallel fibers. The axon of the Golgi cell ramifies densely in the granule layer and enters into a complex arrangement with mossy fiber terminals and granule cell dendrites to form the cerebellar glomerulus. Llinas, Walton and Lang. In The Synaptic Organization of the Brain. 5th ed. 2004." [NIFSTD:sao1415726815]
subset: cellxgene_subset
synonym: "cerebellar Golgi neuron" EXACT []
synonym: "cerebellum Golgi cell" EXACT []
synonym: "Golgi cell" EXACT []
synonym: "Golgi neuron" EXACT []
xref: MESH:D000080906
xref: ZFA:0009069 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:4023057 ! cerebellar inhibitory GABAergic interneuron
relationship: RO:0002100 UBERON:0002956 ! has soma location granular layer of cerebellar cortex
relationship: RO:0002113 UBERON:0002956 ! has presynaptic terminal in granular layer of cerebellar cortex
relationship: RO:0002360 UBERON:0002974 ! has dendrite location molecular layer of cerebellar cortex
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000119" xsd:string {name="cerebellar Golgi cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000120
name: granule cell
def: "A neuron of the vertebrate central nervous system that is small in size. This general class includes small neurons in the granular layer of the cerebellar cortex, cerebral cortex neurons that are not pyramidal cells and small neurons without axons found in the olfactory bulb." [https://medical-dictionary.thefreedictionary.com/granule+cell]
subset: cellxgene_subset
xref: BTO:0003393
xref: ZFA:0009070 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:2000029 ! central nervous system neuron
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000120" xsd:string {name="granule cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000121
name: Purkinje cell
def: "An inhibitory neuron and the sole output neuron of the cerebellar cortex, the Purkinje cell's soma is located between the granular and molecular layers of the cerebellum. It is one of the largest neural cells in the mammalian brain, ranging from 50 to 80 micrometres in diameter. Purkinje cells have planar, fan-shaped dendrites that branch extensively with little overlap. This cell type receives synaptic input from parallel fibres, which modulate high-frequency spike activity known as \"simple spikes,\" and climbing fibres, which modulate infrequent calcium spike activity known as \"complex spikes\". Purkinje cells are involved in motor coordination, particularly in correcting movements in progress." [MESH:D011689, PMID:12907269, PMID:14568361, PMID:31424738, PMID:33288911, PMID:38168772]
comment: Neurodegenerative disorders affecting Purkinje cells disrupt motor functions. Some of the neurodegenerative disorders that causes loss and degeration of Purkinje cells are Spinocerebellar ataxias (SCAs) (Josef P Kapfhammer and Etsuko Shimobayashi 2023), Friedreich's ataxia (FRDA) (Kevin C Kemp et al., 2016), Fetal alcohol syndrome (Laurent Servais et al., 2016), Dandy-Walker malformation (Alexander Atamian et al., 2024). {xref="PMID:27215193", xref="PMID:17535929", xref="PMID:37426070", xref="https://doi.org/10.1016/j.stem.2023.11.013"}
subset: cellxgene_subset
synonym: "cerebellar Purkinje cell" EXACT [https://doi.org/10.1016/j.proghi.2004.07.002]
synonym: "PC" RELATED OMO:0003000 [PMID:38168772]
synonym: "PN" RELATED OMO:0003000 [PMID:28821816]
synonym: "Purkinje neuron" EXACT [PMID:28821816]
xref: BTO:0001011
xref: CALOHA:TS-0845
xref: FMA:67969
xref: ZFA:0009071 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000617 ! GABAergic neuron
is_a: CL:1001611 ! cerebellar neuron
relationship: RO:0002100 UBERON:0002979 ! has soma location Purkinje cell layer of cerebellar cortex
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000121" xsd:string {name="Purkinje cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000122
name: stellate neuron
def: "A neuron that has dendritic processes radiating from the cell body forming a star-like shape." [ISBN:9780123973481]
subset: BDS_subset
subset: cellxgene_subset
xref: BTO:0002316
xref: ZFA:0009072 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0000053 PATO:0070010 ! has characteristic stellate morphology
relationship: RO:0000053 PATO:0070010 ! has characteristic stellate morphology
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000122" xsd:string {name="stellate neuron on CELLxGENE CellGuide"}
[Term]
id: CL:0000123
name: neuron associated cell (sensu Vertebrata)
subset: cellxgene_subset
is_a: CL:0000095 ! neuron associated cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
[Term]
id: CL:0000125
name: glial cell
def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." [MESH:D009457]
comment: Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "neuroglia" RELATED []
synonym: "neuroglial cell" EXACT []
xref: BTO:0002606
xref: CALOHA:TS-0415
xref: FBbt:00005144 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
xref: FMA:54536
xref: ZFA:0009073 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000095 ! neuron associated cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000125" xsd:string {name="glial cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000126
name: macroglial cell
def: "A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together." [GOC:tfm, ISBN:0721662544]
subset: cellxgene_subset
synonym: "macroglia" RELATED OMO:0003004 [doi:10.1152/physrev.2001.81.2.871]
synonym: "macrogliocyte" EXACT []
xref: BTO:0000771
xref: CALOHA:TS-2027
xref: FMA:54538
xref: ZFA:0009074 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000125 ! glial cell
relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata)
[Term]
id: CL:0000127
name: astrocyte
def: "A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury." [GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Astrocyte, MESH:D001253, PMID:11746784, PMID:12162730, PMID:12898703, PMID:20942978]
comment: Astrocytes are reportedly CD68-negative, CD121a-positive, CD184-positive, CD192-positive, CRF-positive, EGFR-positive, GFAP-positive, GLUT1-positive, MBP-negative, and NGFR-positive.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "astrocytic glia" EXACT []
xref: BTO:0000099
xref: CALOHA:TS-0060
xref: FMA:54537
xref: ZFA:0009075 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000126 ! macroglial cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000128
name: oligodendrocyte
def: "A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system." [http://en.wikipedia.org/wiki/Oligodendrocyte, MESH:D009836]
comment: Oligodendrocytes are reportedly MDP-positive and CD4-negative.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "oligodendroglia" RELATED []
synonym: "OLs" EXACT [PMID:8734446]
xref: BTO:0000962
xref: CALOHA:TS-0709
xref: FMA:54540
xref: ZFA:0009076 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000126 {is_inferred="true"} ! macroglial cell
is_a: CL:4023154 ! myelinating glial cell
relationship: develops_from CL:0002453 ! oligodendrocyte precursor cell
relationship: part_of UBERON:0001017 ! central nervous system
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000131
name: gut endothelial cell
def: "An endothelial cell that lines the blood and lymphatic vessels of the digestive tract. This cell forms the gut–vascular barrier (GVB) through tight junctions and crosstalk with pericytes and enteric glial cells, regulating the passage of nutrients and immune cells while restricting microbial translocation into the bloodstream." [PMID:26564856]
subset: cellxgene_subset
xref: ZFA:0009078 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000115 ! endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0001555 ! digestive tract
relationship: develops_from CL:0000223 ! endodermal cell
relationship: part_of UBERON:0001555 ! digestive tract
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000131" xsd:string {name="gut endothelial cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000133
name: neurectodermal cell
def: "Ectoderm destined to be nervous tissue." [GOC:tfm, ISBN:068340007X]
subset: cellxgene_subset
synonym: "neurectoderm cell" EXACT []
xref: ZFA:0009080 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000221 ! ectodermal cell
[Term]
id: CL:0000134
name: mesenchymal stem cell
def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." [FB:ma, GOC:dsd, http://en.wikipedia.org/wiki/Mesenchymal_stem_cell, http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells, PMCID:PMC2613570, PMID:10102814, PMID:16923606, PMID:17986482, PMID:19960544]
comment: Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2.
subset: cellxgene_subset
synonym: "BMSC" RELATED OMO:0003000 []
synonym: "bone marrow stromal cells" NARROW []
synonym: "CFU-F" RELATED OMO:0003000 []
synonym: "colony-forming unit-fibroblast" NARROW []
synonym: "marrow stromal cells" NARROW [PMID:11378515]
synonym: "mesenchymal precursor cell" RELATED []
synonym: "mesenchymal progenitor cells" RELATED OMO:0003004 [MESH:D044982]
synonym: "mesenchymal stem cell" RELATED []
synonym: "mesenchymal stromal cell" RELATED []
synonym: "mesenchymal stromal cells" RELATED OMO:0003004 []
synonym: "MSC" RELATED OMO:0003000 [PMID:11378515]
synonym: "stem cells, mesenchymal" RELATED OMO:0003004 [MESH:D044982]
xref: BTO:0002625
xref: BTO:0003298
xref: FMA:70546
xref: ZFA:0009081 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000048 ! multi fate stem cell
is_a: CL:0002320 {is_inferred="true"} ! connective tissue cell
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000134" xsd:string {name="mesenchymal stem cell on CELLxGENE CellGuide"}
property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/474" xsd:string
[Term]
id: CL:0000136
name: adipocyte
def: "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides." [MESH:D017667]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "adipose cell" EXACT []
synonym: "fat cell" EXACT []
xref: BTO:0000443
xref: CALOHA:TS-0012
xref: FMA:63880
xref: ZFA:0009082 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000325 ! stuff accumulating cell
is_a: CL:0002320 ! connective tissue cell
relationship: develops_from CL:0000134 ! mesenchymal stem cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000136" xsd:string {name="adipocyte on CELLxGENE CellGuide"}
[Term]
id: CL:0000137
name: osteocyte
def: "A mature osteoblast that has become embedded in the bone matrix. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi." [GOC:tfm, MESH:D010011]
comment: VSAO relationship simplified OBO_REL:integral_part_of VSAO:0000118
synonym: "bone cell" BROAD []
xref: BTO:0002038
xref: CALOHA:TS-1167
xref: FMA:66779
xref: VSAO:0000124
xref: ZFA:0009083 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0001035 ! bone cell
is_a: CL:0002320 ! connective tissue cell
relationship: develops_from CL:0001040 ! non-terminally differentiated osteoblast
relationship: part_of UBERON:0002481 ! bone tissue
[Term]
id: CL:0000138
name: chondrocyte
def: "A skeletogenic cell that secretes a specialized, avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell." [GO_REF:0000034, MESH:D019902, PMID:32491508]
subset: cellxgene_subset
synonym: "cartilage cell" EXACT []
xref: BTO:0000249
xref: CALOHA:TS-0138
xref: FMA:66782
xref: ZFA:0009084 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000153 ! glycosaminoglycan secreting cell
is_a: CL:0000667 ! collagen secreting cell
is_a: CL:0007001 ! skeletogenic cell
relationship: develops_from CL:0000058 ! chondroblast
relationship: located_in UBERON:0002418 ! cartilage tissue
[Term]
id: CL:0000145
name: professional antigen presenting cell
def: "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." [GOC:add, ISBN:0781735149]
comment: Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells.
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
synonym: "APC" RELATED OMO:0003000 []
xref: ZFA:0009088 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000738 ! leukocyte
intersection_of: CL:0000738 ! leukocyte
intersection_of: capable_of GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
relationship: capable_of GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000145" xsd:string {name="professional antigen presenting cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000146
name: simple columnar epithelial cell
subset: human_reference_atlas
xref: ZFA:0009089 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000147
name: pigment cell
def: "A pigment cell is a cell that contains pigment granules." [GOC:tfm]
synonym: "chromatocyte" EXACT []
synonym: "chromatophore" EXACT []
xref: VHOG:0001678
xref: ZFA:0009090 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000325 ! stuff accumulating cell
[Term]
id: CL:0000148
name: melanocyte
def: "A pigment cell derived from the neural crest. Contains melanin-filled pigment granules, which gives a brown to black appearance." [SANBI:mhl]
subset: cellxgene_subset
subset: general_cell_types_upper_slim
subset: human_reference_atlas
synonym: "melanophore" NARROW []
xref: BTO:0000847
xref: CALOHA:TS-0613
xref: FMA:70545
xref: MESH:D008544
xref: VHOG:0001679
xref: ZFA:0009091 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000147 ! pigment cell
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000147 ! pigment cell
intersection_of: develops_from CL:0000541 ! melanoblast
intersection_of: has_part GO:0042470 ! melanosome
relationship: develops_from CL:0000541 ! melanoblast
relationship: has_part GO:0042470 ! melanosome
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000148" xsd:string {name="melanocyte on CELLxGENE CellGuide"}
[Term]
id: CL:0000149
name: visual pigment cell
synonym: "pigment cell" BROAD []
is_a: CL:0000147 ! pigment cell
[Term]
id: CL:0000150
name: glandular secretory epithelial cell
def: "An epithelial cell, located in a gland, that is specialised for the synthesis and secretion of specific biomolecules, such as hormones, or mucous." [GOC:tfm, ORCID:0000-0002-7073-9172]
subset: cellxgene_subset
synonym: "glandular epithelial cell" EXACT []
xref: CALOHA:TS-2085
xref: FMA:86494
is_a: CL:1100001 ! secretory epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: part_of UBERON:0002530 ! gland
relationship: part_of UBERON:0002530 ! gland
[Term]
id: CL:0000151
name: secretory cell
def: "A cell that specializes in controlled release of one or more substances." [GOC:tfm, ISBN:0721662544]
subset: cellxgene_subset
xref: BTO:0003659
xref: FMA:86916
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: capable_of GO:0032940 ! secretion by cell
relationship: capable_of GO:0032940 ! secretion by cell
[Term]
id: CL:0000152
name: exocrine cell
def: "A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct." [ISBN:0198547684]
subset: cellxgene_subset
xref: FMA:16014
xref: ZFA:0009092 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000151 ! secretory cell
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: part_of UBERON:0002365 ! exocrine gland
relationship: part_of UBERON:0002365 ! exocrine gland
[Term]
id: CL:0000153
name: glycosaminoglycan secreting cell
def: "A cell that secretes glycosaminoglycans." [GOC:tfm]
synonym: "GAG secreting cell" EXACT []
synonym: "hyaluronic acid secreting cell" NARROW []
xref: ZFA:0009093 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000327 ! extracellular matrix secreting cell
is_a: CL:0000447 ! carbohydrate secreting cell
[Term]
id: CL:0000154
name: protein secreting cell
def: "Any secretory cell that is capable of some protein secretion." [FBC:Autogenerated]
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0009306 ! protein secretion
relationship: capable_of GO:0009306 ! protein secretion
[Term]
id: CL:0000155
name: peptic cell
def: "An epithelial cell of the stomach that is part of the fundic gastric gland. This cell is characterized by a basally located nucleus, abundant rough endoplasmic reticulum, and large apical secretory granules. It produces and secretes pepsinogen, the inactive precursor of the digestive enzyme pepsin." [GOC:tfm, PMID:21907708, PMID:30571046, Wikipedia:Gastric_chief_cell]
subset: cellxgene_subset
synonym: "chief cell of stomach" EXACT []
synonym: "gastric chief cell" EXACT [Wikipedia:Chief_cell]
synonym: "pepsinogen secreting cell" EXACT []
synonym: "zymogenic cell" EXACT [Wikipedia:Chief_cell]
xref: FMA:62902
is_a: CL:0000152 ! exocrine cell
is_a: CL:0000154 ! protein secreting cell
is_a: CL:0002659 ! glandular epithelial cell of stomach
relationship: part_of UBERON:0010038 ! fundic gastric gland
[Term]
id: CL:0000157
name: surfactant secreting cell
def: "A cell that specializes in secretion of surfactant in the alveoli of the lung." [GOC:tfm, ISBN:0721662544]
is_a: CL:0000151 {is_inferred="true"} ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0043129 ! surfactant homeostasis
relationship: capable_of GO:0043129 ! surfactant homeostasis
[Term]
id: CL:0000158
name: club cell
def: "A non-mucous, epithelial secretory cell that is part of the tracheobronchial tree. A club cell has short microvilli but no cilia. A club cell is able to multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium and it also protects the tracheobronchial epithelium." [DOI:10.1183/09031936.00146609, DOI:10.1378/chest.12-2762, GOC:tfm, PMID:28128362, PMID:29874100, PMID:7905712]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "Clara cell" EXACT []
xref: BTO:0004811
xref: FMA:14119
is_a: CL:0000157 ! surfactant secreting cell
is_a: CL:0002202 ! epithelial cell of tracheobronchial tree
is_a: CL:0008055 ! respiratory tract secretory epithelial cell
is_a: CL:0011026 ! progenitor cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 GO:0005902 ! has plasma membrane part microvillus
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000158" xsd:string {name="club cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000159
name: seromucus secreting cell
subset: cellxgene_subset
is_a: CL:0000151 ! secretory cell
[Term]
id: CL:0000160
name: goblet cell
def: "A specialized, columnar, mucus secreting epithelial cell shaped like a flask or goblet. A narrow basal end contains the nucleus while the apical end is swollen by the accumulation of mucus laden secretory granules. Short microvilli project from the apical plasma membrane." [http://en.wikipedia.org/wiki/Goblet_cell, MESH:D020397]
subset: cellxgene_subset
synonym: "chalice cell" EXACT []
xref: BTO:0001540
xref: FMA:13148
xref: http://en.wikipedia.org/wiki/Goblet_cell
xref: ZFA:0009094 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000319 ! mucus secreting cell
is_a: CL:1100001 ! secretory epithelial cell
relationship: has_part GO:0005902 ! microvillus
relationship: has_part GO:0098594 ! mucin granule
property_value: depiction "https://upload.wikimedia.org/wikipedia/commons/thumb/c/c4/404_Goblet_Cell_new.jpg/800px-404_Goblet_Cell_new.jpg" xsd:string {xref="http://cnx.org/content/col11496/1.6/", xref="https://commons.wikimedia.org/w/index.php?curid=30131227"}
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000160" xsd:string {name="goblet cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000162
name: parietal cell
def: "An epithelial cell of the stomach that is part of the fundic gastric gland. This cell is characterized by its pyramidal shape, abundant mitochondria, and a complex network of secretory canaliculi lined with microvilli. It secretes hydrochloric acid into the stomach lumen and produces intrinsic factor, essential for vitamin B12 absorption." [GOC:tfm, ISBN:0517223651, PMID:31613538, PMID:31670611]
comment: Parietal cells have dynamic, actin-supported microvilli that increase in number during active secretion, playing a crucial role in secreting hydrochloric acid and intrinsic factor. The structure and regulation of these microvilli are influenced by proteins such as ASAP3, which modulates Arf6 activity and actin assembly, thereby controlling microvilli formation and parietal cell function. {xref="PMID:31613538", xref="PMID:29263912"}
subset: cellxgene_subset
synonym: "gastric parietal cell" EXACT [PMID:29263912]
synonym: "oxyntic cell" EXACT [Wikipedia:Parietal_cell]
xref: BTO:0001780
xref: FMA:62901
is_a: CL:0000152 ! exocrine cell
is_a: CL:0002659 ! glandular epithelial cell of stomach
relationship: capable_of GO:0001696 ! gastric acid secretion
relationship: has_part GO:0005902 ! microvillus
relationship: part_of UBERON:0010038 ! fundic gastric gland
[Term]
id: CL:0000163
name: endocrine cell
def: "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions." [MESH:D055098]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "endocrinocyte" EXACT []
xref: FMA:83809
xref: ZFA:0009096 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000151 ! secretory cell
is_a: CL:0000164 {gci_relation="part_of", gci_filler="UBERON:0000945"} ! enteroendocrine cell
is_a: CL:0000164 {gci_filler="UBERON:0000160", gci_relation="part_of"} ! enteroendocrine cell
is_a: CL:0000164 {gci_filler="UBERON:0001264", gci_relation="part_of"} ! enteroendocrine cell
is_a: CL:0000255 ! eukaryotic cell
relationship: part_of UBERON:0000949 ! endocrine system
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000164
name: enteroendocrine cell
def: "An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas." [GOC:tfm, SANBI:mhl]
subset: cellxgene_subset
xref: BTO:0003865
xref: FMA:62930
xref: MESH:D019858
xref: ZFA:0009097 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000163 ! endocrine cell
is_a: CL:1100001 ! secretory epithelial cell
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000164" xsd:string {name="enteroendocrine cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000165
name: neuroendocrine cell
def: "A neuron that is capable of some hormone secretion in response to neuronal signals." [MESH:D055099]
comment: The neurosecretory cell is neither an ordinary neuron nor an endocrine cell, but a combination of both. Its neuronal features resemble those of ordinary neurons concerning both structure and function. The production of a visible secretory material marks the neurosecretory neuron as a gland cell, and the fact that extractable cellular products act in the manner of hormones places it in the realm of endocrine elements. \n\nThe modern definition of neurosecretion has evolved to include the release of any neuronal secretory product from a neuron. {xref="https://www.clinicalkey.com/#!/content/book/3-s2.0-B9780323555968000073", xref="PMID:5342440"}
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "neurosecretory cell" RELATED []
synonym: "neurosecretory neuron" RELATED []
xref: BTO:0002691
xref: FBbt:00005130 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
xref: FMA:83810
xref: ZFA:0009098 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000163 ! endocrine cell
is_a: CL:0000527 ! efferent neuron
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:1100001 ! secretory epithelial cell
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0046879 ! hormone secretion
relationship: capable_of GO:0046879 ! hormone secretion
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000166
name: chromaffin cell
def: "A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system." [MESH:D019439]
subset: cellxgene_subset
synonym: "phaeochromocyte" EXACT []
xref: BTO:0000259
xref: FMA:69263
xref: ZFA:0009099 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000029 ! neural crest derived neuron
is_a: CL:0000568 ! amine precursor uptake and decarboxylation cell
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000166" xsd:string {name="chromaffin cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000167
name: peptide hormone secreting cell
def: "Any secretory cell that is capable of some peptide hormone secretion." [FBC:Autogenerated]
xref: ZFA:0009100 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0030072 ! peptide hormone secretion
relationship: capable_of GO:0030072 ! peptide hormone secretion
[Term]
id: CL:0000168
name: insulin secreting cell
def: "Any secretory cell that is capable of some insulin secretion." [FBC:Autogenerated]
xref: BTO:0000783
xref: ZFA:0009101 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000154 ! protein secreting cell
is_a: CL:0000167 ! peptide hormone secreting cell
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0030073 ! insulin secretion
relationship: capable_of GO:0030073 ! insulin secretion
[Term]
id: CL:0000169
name: type B pancreatic cell
def: "A cell that secretes insulin and is located towards the center of the islets of Langerhans." [GOC:tfm, http://en.wikipedia.org/wiki/Pancreatic_b_cell, ISBN:0517223651]
comment: Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "B-cell of pancreatic islet" EXACT [FMA:70586]
synonym: "beta cell" BROAD [ZFA:0009102]
synonym: "beta cell islet" RELATED [MA:0002419]
synonym: "beta cell of pancreatic islet" EXACT [FMA:70586]
synonym: "insulin-secreting cell" EXACT [FMA:70586]
synonym: "pancreatic B cell" EXACT []
synonym: "pancreatic B-cell" EXACT [FMA:70586]
synonym: "pancreatic beta cell" EXACT [FMA:70586]
synonym: "pancreatic islet core" EXACT [MA:0002419]
synonym: "type B enteroendocrine cell" EXACT [FMA:70586]
xref: BTO:0000783
xref: EV:0200009
xref: FMA:70586
xref: MA:0002419
xref: ncithesaurus:Beta_Cell
xref: ZFA:0009102 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000168 {is_inferred="true"} ! insulin secreting cell
is_a: CL:0008024 ! pancreatic endocrine cell
intersection_of: CL:0000164 ! enteroendocrine cell
intersection_of: capable_of GO:0030073 ! insulin secretion
intersection_of: part_of UBERON:0000006 ! islet of Langerhans
relationship: capable_of GO:0030073 ! insulin secretion
relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas
relationship: part_of UBERON:0000006 ! islet of Langerhans
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000169" xsd:string {name="type B pancreatic cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000170
name: glucagon secreting cell
def: "A cell that secretes glucagon." [GOC:tfm]
synonym: "glucagon-secreting cell" EXACT []
xref: FMA:84045
xref: ZFA:0009103 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0070091 ! glucagon secretion
relationship: capable_of GO:0070091 ! glucagon secretion
[Term]
id: CL:0000171
name: pancreatic A cell
def: "A type A enteroendocrine cell found in the periphery of the islets of Langerhans that secretes glucagon." [GOC:tfm, ISBN:0721662544]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "alpha cell of islet of Langerhans" EXACT []
synonym: "pancreatic alpha cell" EXACT []
xref: BTO:0000990
xref: FMA:70585
xref: MESH:D050416
xref: ZFA:0009104 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0002067 ! type A enteroendocrine cell
is_a: CL:0008024 ! pancreatic endocrine cell
intersection_of: CL:0002067 ! type A enteroendocrine cell
intersection_of: part_of UBERON:0000006 ! islet of Langerhans
relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas
relationship: part_of UBERON:0000006 ! islet of Langerhans
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000171" xsd:string {name="pancreatic A cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000172
name: somatostatin secreting cell
def: "Any secretory cell that is capable of some somatostatin secretion." [FBC:Autogenerated]
xref: ZFA:0009105 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0070253 ! somatostatin secretion
relationship: capable_of GO:0070253 ! somatostatin secretion
[Term]
id: CL:0000173
name: pancreatic D cell
def: "A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin." [FMA:0517223651, GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "D-cell of pancreatic islet" EXACT []
synonym: "delta cell of islet" EXACT []
synonym: "delta cell of pancreatic islet" EXACT []
synonym: "pancreatic D-cell" EXACT []
synonym: "pancreatic delta cell" EXACT []
synonym: "somatostatin-secreting pancreatic cell" EXACT []
xref: BTO:0000803
xref: FMA:70587
xref: ZFA:0005743 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000502 ! type D enteroendocrine cell
is_a: CL:0008024 ! pancreatic endocrine cell
intersection_of: CL:0000502 ! type D enteroendocrine cell
intersection_of: part_of UBERON:0001264 ! pancreas
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas
relationship: part_of UBERON:0000006 ! islet of Langerhans
relationship: part_of UBERON:0001264 ! pancreas
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000173" xsd:string {name="pancreatic D cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000174
name: steroid hormone secreting cell
def: "Any secretory cell that is capable of some steroid hormone secretion." [FBC:Autogenerated]
xref: ZFA:0009106 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0035929 ! steroid hormone secretion
relationship: capable_of GO:0035929 ! steroid hormone secretion
[Term]
id: CL:0000175
name: luteal cell
def: "A progesterone secreting cell in the corpus luteum. The large luteal cells develop from the granulosa cells. The small luteal cells develop from the theca cells." [MESH:D008184, PMID:31849844]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "corpus luteum cell" EXACT [PMID:16790079]
synonym: "lutein cell" EXACT []
xref: BTO:0003939
xref: FMA:18688
is_a: CL:0000179 ! progesterone secreting cell
relationship: part_of UBERON:0002512 ! corpus luteum
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000177
name: testosterone secreting cell
def: "Any secretory cell that is capable of some testosterone secretion." [FBC:Autogenerated]
xref: ZFA:0009107 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0035936 ! testosterone secretion
relationship: capable_of GO:0035936 ! testosterone secretion
[Term]
id: CL:0000178
name: Leydig cell
def: "A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis." [GOC:tfm, PMID:12050120]
comment: Note that the Amphibian Anatomy Ontology (AA) has a class 'leydig cells' but this is unrelated
subset: cellxgene_subset
synonym: "interstitial cell" BROAD []
synonym: "interstitial cell of Leydig" EXACT []
xref: BTO:0000755
xref: CALOHA:TS-1150
xref: EMAPA:29655
xref: FMA:72297
xref: MESH:D007985
xref: ZFA:0009108 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000177 ! testosterone secreting cell
is_a: CL:4030031 ! interstitial cell
relationship: develops_from CL:0009091 ! Leydig stem cell
relationship: part_of UBERON:0005212 ! Leydig cell region of testis
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000178" xsd:string {name="Leydig cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000179
name: progesterone secreting cell
def: "Any secretory cell that is capable of some progesterone secretion." [FBC:Autogenerated]
xref: ZFA:0009109 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000174 ! steroid hormone secreting cell
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0042701 ! progesterone secretion
relationship: capable_of GO:0042701 ! progesterone secretion
[Term]
id: CL:0000182
name: hepatocyte
def: "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated." [GOC:tfm, http://en.wikipedia.org/wiki/Hepatocyte, ISBN:0412046911, MESH:D022781, PMID:19717280]
comment: Hepatocytes are reportedly MHC Class I-positive and MHC Class II-positive.
subset: cellxgene_subset
subset: human_reference_atlas
xref: BTO:0000575
xref: CALOHA:TS-0454
xref: FMA:14515
xref: ZFA:0009111 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000417 ! endopolyploid cell
relationship: capable_of GO:0006699 ! bile acid biosynthetic process
relationship: capable_of GO:0098754 ! detoxification
relationship: develops_from CL:0005026 ! hepatoblast
relationship: part_of UBERON:0002107 ! liver
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000182" xsd:string {name="hepatocyte on CELLxGENE CellGuide"}
[Term]
id: CL:0000183
name: contractile cell
def: "A cell whose primary function is to shorten." [FB:ma]
subset: cellxgene_subset
is_a: CL:0000000 ! cell
[Term]
id: CL:0000185
name: myoepithelial cell
def: "Contractile cells resembling smooth muscle cells that are present in glands, notably the mammary gland, and aid in secretion. This cell has long weaving dendritic processes containing myofilament." [GOC:tfm, ISBN:0721662544]
subset: cellxgene_subset
synonym: "basket epithelial cell" EXACT []
synonym: "myoepitheliocyte" EXACT []
xref: BTO:0002309
xref: CALOHA:TS-2379
xref: FMA:67799
xref: ZFA:0009113 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
is_a: CL:0000183 ! contractile cell
[Term]
id: CL:0000187
name: muscle cell
def: "A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [MESH:D032342]
subset: cellxgene_subset
subset: general_cell_types_upper_slim
synonym: "muscle fiber" EXACT []
synonym: "myocyte" EXACT []
xref: BTO:0000888
xref: BTO:0000902
xref: CALOHA:TS-2032
xref: FBbt:00005074 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
xref: FMA:67328
xref: WBbt:0003675
xref: ZFA:0009114 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000183 ! contractile cell
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000393 ! electrically responsive cell
relationship: develops_from CL:0000056 ! myoblast
property_value: depiction "https://www.swissbiopics.org/api/image/Muscle_cells.svg" xsd:anyURI
[Term]
id: CL:0000188
name: cell of skeletal muscle
def: "A somatic cell located in skeletal muscle." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "skeletal muscle cell" EXACT []
xref: BTO:0004392
xref: CALOHA:TS-2158
xref: FMA:9727
xref: ZFA:0009115 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue
relationship: part_of UBERON:0001134 ! skeletal muscle tissue
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000188" xsd:string {name="cell of skeletal muscle on CELLxGENE CellGuide"}
[Term]
id: CL:0000189
name: slow muscle cell
def: "A muscle cell that develops tension more slowly than a fast-twitch fiber." [GOC:tfm, ISBN:0323052908]
subset: cellxgene_subset
synonym: "slow muscle fiber" RELATED [ISBN:0815316208]
xref: ZFA:0009116 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0008046 ! extrafusal muscle fiber
relationship: develops_from CL:0000857 ! slow muscle myoblast
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000189" xsd:string {name="slow muscle cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000190
name: fast muscle cell
def: "A muscle cell that can develop high tension rapidly. It is usually innervated by a single alpha neuron." [GOC:tfm, ISBN:0323052908]
subset: cellxgene_subset
synonym: "glycolytic muscle fiber" EXACT []
xref: ZFA:0009117 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0008046 ! extrafusal muscle fiber
relationship: develops_from CL:0000858 ! fast muscle myoblast
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000190" xsd:string {name="fast muscle cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000192
name: smooth muscle cell
def: "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)." [http://en.wikipedia.org/wiki/Smooth_muscle_cell, MESH:D032389, PMID:9315361]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "myocytes, smooth muscle" EXACT [MESH:D032389]
synonym: "non-striated muscle cell" BROAD []
synonym: "SMCs" EXACT [PMID:9315361]
synonym: "smooth muscle fiber" EXACT []
xref: BTO:0004576
xref: CALOHA:TS-2159
xref: FMA:14072
xref: ZFA:0009118 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0008000 ! non-striated muscle cell
is_a: CL:0008007 ! visceral muscle cell
relationship: develops_from CL:0000514 ! smooth muscle myoblast
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000192" xsd:string {name="smooth muscle cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000197
name: sensory receptor cell
def: "A cell that is capable of detection of a stimulus involved in sensory perception." []
synonym: "receptor cell" EXACT []
xref: MESH:D011984
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
intersection_of: part_of UBERON:0001032 ! sensory system
relationship: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
relationship: part_of UBERON:0001032 ! sensory system
[Term]
id: CL:0000198
name: pain receptor cell
def: "The peripheral receptor for pain. Includes receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. All mammalian nociceptors are free nerve endings." [MESH:D009619]
comment: Editor note: request detection of stimulus involved in sensory perception of pain; add develops_from relationship
synonym: "nociceptor" EXACT [] {seeAlso="https://meshb.nlm.nih.gov/record/ui?ui=D009619"}
synonym: "nocireceptor" EXACT [] {seeAlso="https://www.thefreedictionary.com/nocireceptor"}
xref: ZFA:0009119 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000006 ! neuronal receptor cell
[Term]
id: CL:0000199
name: mechanoreceptor cell
def: "A cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system." [MESH:D008465]
subset: cellxgene_subset
synonym: "mechanoreceptor" RELATED [MP:0000972]
xref: ZFA:0009120 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000101 ! sensory neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0050974 ! detection of mechanical stimulus involved in sensory perception
relationship: capable_of GO:0050974 ! detection of mechanical stimulus involved in sensory perception
[Term]
id: CL:0000200
name: touch receptor cell
def: "Any neuron that is capable of some detection of mechanical stimulus involved in sensory perception of touch." [FBC:Autogenerated]
is_a: CL:0000199 ! mechanoreceptor cell
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0050976 ! detection of mechanical stimulus involved in sensory perception of touch
relationship: capable_of GO:0050976 ! detection of mechanical stimulus involved in sensory perception of touch
[Term]
id: CL:0000202
name: auditory hair cell
def: "A mechanoreceptor cell of the auditory or vestibular system that is sensitive to auditory stimuli. The accessory sensory structures are arranged so that appropriate stimuli cause movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." [MESH:D006198, WikipediaVersioned:Hair_cell&oldid=1045345915]
comment: In mammals these cells are located in the organ of Corti.
synonym: "auditory receptor cell" RELATED []
xref: ZFA:0009121 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000855 ! sensory hair cell
relationship: capable_of GO:0050910 ! detection of mechanical stimulus involved in sensory perception of sound
[Term]
id: CL:0000206
name: chemoreceptor cell
def: "A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood." [MESH:D002628]
xref: ZFA:0009124 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000197 ! sensory receptor cell
intersection_of: CL:0000197 ! sensory receptor cell
intersection_of: capable_of GO:0050907 ! detection of chemical stimulus involved in sensory perception
relationship: capable_of GO:0050907 ! detection of chemical stimulus involved in sensory perception
[Term]
id: CL:0000207
name: olfactory receptor cell
def: "Any neuron that is capable of some detection of chemical stimulus involved in sensory perception of smell." [FBC:Autogenerated]
subset: cellxgene_subset
synonym: "odorant receptor cell" EXACT []
synonym: "olfactory receptor neuron" EXACT []
synonym: "olfactory sensory neuron" EXACT []
synonym: "Schultze's cell" EXACT []
xref: BTO:0004185
xref: FMA:67860
xref: MESH:D018034
xref: Wikipedia:Olfactory_receptor_neuron
xref: ZFA:0009125 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000206 ! chemoreceptor cell
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0050911 ! detection of chemical stimulus involved in sensory perception of smell
relationship: capable_of GO:0050911 ! detection of chemical stimulus involved in sensory perception of smell
relationship: part_of UBERON:0005725 ! olfactory system
[Term]
id: CL:0000209
name: taste receptor cell
def: "A specialized cell involved in gustatory sensory perception." [GOC:tfm, ISBN:0618947256]
subset: cellxgene_subset
synonym: "taste bud cell" EXACT []
xref: FMA:67910
xref: ZFA:0009126 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000098 ! sensory epithelial cell
is_a: CL:0000206 ! chemoreceptor cell
is_a: CL:0002076 ! endo-epithelial cell
intersection_of: CL:0000206 ! chemoreceptor cell
intersection_of: capable_of GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste
relationship: capable_of GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000209" xsd:string {name="taste receptor cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000210
name: photoreceptor cell
def: "A cell specialized in detecting light stimuli that are involved in visual perception." [MESH:D010786]
subset: cellxgene_subset
xref: BTO:0001060
xref: CALOHA:TS-0868
xref: FBbt:00004211 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
xref: FMA:86740
xref: ZFA:0009127 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000101 ! sensory neuron
is_a: CL:0008028 ! visual system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0050908 ! detection of light stimulus involved in visual perception
relationship: capable_of GO:0050908 ! detection of light stimulus involved in visual perception
property_value: depiction "https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg" xsd:anyURI
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000210" xsd:string {name="photoreceptor cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000211
name: electrically active cell
def: "A cell whose function is determined by the generation or the reception of an electric signal." [FB:ma]
xref: ZFA:0009128 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000000 ! cell
[Term]
id: CL:0000214
name: synovial cell
def: "A cell located in the synovial joint." []
synonym: "synoviocyte" EXACT []
xref: CALOHA:TS-0995
xref: ZFA:0009131 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0002078 {is_inferred="true"} ! meso-epithelial cell
relationship: part_of UBERON:0002217 ! synovial joint
[Term]
id: CL:0000216
name: Sertoli cell
def: "A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier." [MESH:D012708]
subset: cellxgene_subset
xref: BTO:0001238
xref: CALOHA:TS-0922
xref: FMA:72298
xref: VHOG:0001348
xref: ZFA:0009133 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000511 ! androgen binding protein secreting cell
is_a: CL:0000630 {is_inferred="true"} ! supporting cell
is_a: CL:0002625 ! seminiferous tubule epithelial cell
is_a: CL:1100001 ! secretory epithelial cell
intersection_of: CL:0000630 ! supporting cell
intersection_of: part_of UBERON:0001343 ! seminiferous tubule of testis
relationship: part_of UBERON:0001343 ! seminiferous tubule of testis
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000216" xsd:string {name="Sertoli cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000218
name: myelinating Schwann cell
def: "A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons." [GOC:cvs, GOC:tfm, MESH:D012583]
subset: cellxgene_subset
synonym: "neurilemmal cell" EXACT []
synonym: "peripheral neuroglial cell" BROAD []
synonym: "Schwann cell" BROAD []
xref: CALOHA:TS-0898
xref: FMA:62121
xref: ZFA:0009135 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0002573 ! Schwann cell
is_a: CL:4023154 ! myelinating glial cell
relationship: develops_from CL:0002377 ! immature Schwann cell
[Term]
id: CL:0000219
name: motile cell
def: "A cell that moves by its own activities." [FB:ma]
xref: ZFA:0009136 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: capable_of GO:0048870 ! cell motility
relationship: capable_of GO:0048870 ! cell motility
[Term]
id: CL:0000221
name: ectodermal cell
def: "A cell of the outer of the three germ layers of the embryo." [MESH:D004475]
subset: cellxgene_subset
synonym: "ectoderm cell" EXACT []
xref: FMA:72549
xref: ZFA:0009137 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0002321 ! embryonic cell (metazoa)
relationship: part_of UBERON:0000924 ! ectoderm
[Term]
id: CL:0000222
name: mesodermal cell
def: "A cell of the middle germ layer of the embryo." [MESH:D008648]
subset: cellxgene_subset
synonym: "mesoblast" EXACT []
synonym: "mesoderm cell" EXACT []
xref: FMA:72554
xref: ZFA:0009138 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0002321 ! embryonic cell (metazoa)
relationship: part_of UBERON:0000926 ! mesoderm
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000222" xsd:string {name="mesodermal cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000223
name: endodermal cell
def: "A cell of the inner of the three germ layers of the embryo." [MESH:D004707]
subset: cellxgene_subset
synonym: "endoderm cell" EXACT []
xref: FMA:72555
xref: ZFA:0009139 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0002321 ! embryonic cell (metazoa)
relationship: part_of UBERON:0000925 ! endoderm
[Term]
id: CL:0000225
name: anucleate cell
def: "A cell that lacks a nucleus." [FB:ma]
synonym: "non-nucleated cell" EXACT []
xref: FMA:68647
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0000053 PATO:0001405 ! has characteristic anucleate
disjoint_from: CL:0002242 ! nucleate cell
relationship: RO:0000053 PATO:0001405 ! has characteristic anucleate
[Term]
id: CL:0000226
name: single nucleate cell
def: "A cell with a single nucleus." [FB:ma, GOC:tfm]
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0000053 PATO:0001407 ! has characteristic mononucleate
relationship: RO:0000053 PATO:0001407 ! has characteristic mononucleate
[Term]
id: CL:0000228
name: multinucleate cell
def: "A cell with more than one nucleus." [FB:ma, Wikipedia:Multinucleate]
synonym: "multinucleated cells" EXACT [Wikipedia:Multinucleate]
synonym: "polynuclear cells" EXACT [Wikipedia:Multinucleate]
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0000053 PATO:0001908 ! has characteristic multinucleate
relationship: RO:0000053 PATO:0001908 ! has characteristic multinucleate
[Term]
id: CL:0000232
name: erythrocyte
def: "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen." [GOC:tfm, MESH:D004912]
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "RBC" EXACT []
synonym: "red blood cell" EXACT []
xref: BTO:0000424
xref: CALOHA:TS-0290
xref: FMA:81100
is_a: CL:0000081 ! blood cell
is_a: CL:0000329 ! oxygen accumulating cell
is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell
intersection_of: CL:0000764 ! erythroid lineage cell
intersection_of: capable_of GO:0008015 ! blood circulation
intersection_of: capable_of GO:0015671 ! oxygen transport
intersection_of: CL:4030045 GO:0005840 ! lacks_part ribosome
intersection_of: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part transferrin receptor protein 1
intersection_of: RO:0000053 PATO:0002039 ! has characteristic biconcave
relationship: capable_of GO:0008015 ! blood circulation
relationship: capable_of GO:0015671 ! oxygen transport
relationship: CL:4030045 GO:0005840 ! lacks_part ribosome
relationship: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part transferrin receptor protein 1
relationship: develops_from CL:0000558 ! reticulocyte
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0000053 PATO:0002039 ! has characteristic biconcave
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000232" xsd:string {name="erythrocyte on CELLxGENE CellGuide"}
[Term]
id: CL:0000233
name: platelet
def: "A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Platelet, MESH:D001792, PMID:11110672, PMID:16987572, PMID:17204662, PMID:17479180, PMID:20414831]
comment: Platelets are reportedly CCR1-positive, CCR2-negative, CCR3-positive, CCR4-positive, CCR5-negative, CCR6-negative, CCR7-negative, CCR8-negative, CCR9-negative, CCR10-negative, CD16-positive, CD23-positive, CD32-positive, CD40-positive, CD41-positive CD42-positive, CD61-positive, CD62P-positive, CD64-positive, CD89-positive, CD102-positive, CD147-positive (activated platelets), CD154-positive (activated platelets), CD162-positive, CD209, CD282-positive, CD284-positive, CD289-positive, CD181-negative, CD182-negative, CD183-negative, CD184-positive, CLEC2-positive, GPVI-positive, JAMC-positive, PAR1-positive, PAR2-negative, PAR3-positive, PAR4-positive, TSP1-positive, and TXA2R-positive. Platelets can reportedly produce CCL2, CCL3, CCL5, CCL7, CCL17, CD40L, CXCL1, CXCL4, CXCL4L1, CXCL5, CXCL7, CXCL8, CXCL12, EGF, factor V, factor VII, factor XI, factor XIII, bFGF, histamine, IGF-1, IL-1beta, PAI-1, PDGF, plasminogen, protein S, serotonin, TGF-beta, TFPI, VEGF, and vWF.
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "anucleate thrombocyte" EXACT []
synonym: "blood platelet" EXACT []
synonym: "enucleate thrombocyte" EXACT []
xref: BTO:0000132
xref: CALOHA:TS-0803
xref: FMA:62851
is_a: CL:0000081 ! blood cell
is_a: CL:0000225 ! anucleate cell
is_a: CL:0000458 ! serotonin secreting cell
is_a: CL:0000763 {is_inferred="true"} ! myeloid cell
relationship: capable_of_part_of GO:0007596 ! blood coagulation
relationship: develops_from CL:0000556 ! megakaryocyte
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0000053 PATO:0001874 ! has characteristic discoid
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000233" xsd:string {name="platelet on CELLxGENE CellGuide"}
[Term]
id: CL:0000234
name: phagocyte
def: "Any cell capable of ingesting particulate matter via phagocytosis." [GOC:add, ISBN:0721601464]
subset: cellxgene_subset
xref: BTO:0001044
xref: FMA:83806
xref: MESH:D010586
xref: ZFA:0009140 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000219 ! motile cell
is_a: CL:0000325 ! stuff accumulating cell
intersection_of: CL:0000000 ! cell
intersection_of: capable_of GO:0006909 ! phagocytosis
relationship: capable_of GO:0006909 ! phagocytosis
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000234" xsd:string {name="phagocyte on CELLxGENE CellGuide"}
[Term]
id: CL:0000235
name: macrophage
def: "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:add, GOC:tfm, PMID:16213494, PMID:1919437]
comment: Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid.
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "histiocyte" EXACT []
xref: BTO:0000801
xref: CALOHA:TS-0587
xref: FMA:63261
xref: FMA:83585
xref: MESH:D008264
xref: ZFA:0009141 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000113 ! mononuclear phagocyte
is_a: CL:0000145 ! professional antigen presenting cell
is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte
intersection_of: CL:0000766 ! myeloid leukocyte
intersection_of: capable_of GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
intersection_of: capable_of GO:0006909 ! phagocytosis
intersection_of: capable_of GO:0031268 ! pseudopodium organization
relationship: capable_of GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
relationship: capable_of GO:0006909 ! phagocytosis
relationship: capable_of GO:0031268 ! pseudopodium organization
relationship: develops_from CL:0000576 ! monocyte
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000235" xsd:string {name="macrophage on CELLxGENE CellGuide"}
[Term]
id: CL:0000236
name: B cell
def: "A lymphocyte of B lineage that is capable of B cell mediated immunity." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149]
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "B lymphocyte" EXACT []
synonym: "B-cell" EXACT []
synonym: "B-lymphocyte" EXACT []
xref: BTO:0000776
xref: CALOHA:TS-0068
xref: FMA:62869
xref: MESH:D001402
xref: VHOG:0001480
xref: ZFA:0009142 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000945 {is_inferred="true"} ! lymphocyte of B lineage
intersection_of: CL:0000945 ! lymphocyte of B lineage
intersection_of: capable_of GO:0019724 ! B cell mediated immunity
relationship: capable_of GO:0019724 ! B cell mediated immunity
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000237
name: keratinizing barrier epithelial cell
subset: cellxgene_subset
is_a: CL:0000240 ! stratified squamous epithelial cell
is_a: CL:0000311 ! keratin accumulating cell
is_a: CL:0002077 ! ecto-epithelial cell
relationship: develops_from CL:0000114 ! surface ectodermal cell
[Term]
id: CL:0000239
name: brush border epithelial cell
def: "An epithelial cell characterized by the presence of a brush border on its apical surface, which increases the surface area for absorption." []
comment: All brush border cells are columnar-cuboidal. The formal logical definition of this term asserts this. Brush border epithelial cells are predominantly found lining the small intestine and the proximal tubules of the kidneys.
xref: https://doi.org/10.1152/ajpgi.00005.2011
xref: PMID:25422372
xref: ZFA:0009143 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: has_part GO:0005903 ! brush border
relationship: has_part GO:0005903 ! brush border
[Term]
id: CL:0000240
name: stratified squamous epithelial cell
def: "A stratified epithelial cell that is part of squamous epithelium, characterized by multiple layers of cells. The basal layer is directly attached to the basement membrane and the apical layer consists of flattened squamous cells. This provides a protective barrier, commonly found in areas subject to abrasion, such as the skin, oral cavity, and esophagus." [PMID:30422572, Wikipedia:Epithelium, Wikipedia:Stratified_squamous_epithelium]
subset: cellxgene_subset
subset: human_reference_atlas
xref: ZFA:0009144 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0000079 ! stratified epithelial cell
intersection_of: CL:0000079 ! stratified epithelial cell
intersection_of: part_of UBERON:0006915 ! stratified squamous epithelium
relationship: part_of UBERON:0006915 ! stratified squamous epithelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000240" xsd:string {name="stratified squamous epithelial cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000241
name: stratified cuboidal epithelial cell
def: "A stratified epithelial cell that is part of cuboidal epithelium, characterized by multiple layers of cuboidal cells forming the apical layer. This provides a protective lining for ducts in large glands, such as sweat glands." [PMID:30422572, Wikipedia:Stratified_cuboidal_epithelium]
subset: human_reference_atlas
xref: ZFA:0009145 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
is_a: CL:0000079 ! stratified epithelial cell
intersection_of: CL:0000079 ! stratified epithelial cell
intersection_of: part_of UBERON:0010077 ! cuboidal epithelium
relationship: part_of UBERON:0010077 ! cuboidal epithelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000242
name: Merkel cell
def: "A specialized epithelial cell located in the skin epidermis and certain mucosal epithelia. It functions as a mechanoreceptor for light touch by forming synapse-like contacts with somatosensory afferent nerve endings, contributing to slowly adapting type I (SAI) tactile responses. Characterized by dense-core neuroendocrine granules, the Merkel cell exhibits both sensory and neuroendocrine properties, including regulated neurotransmitter release via SNARE complex-dependent mechanisms. Its development in mice depends on the transcription factor Atoh1." [MESH:D018862, PMID:19834574, PMID:2274847, PMID:24862916, PMID:30415995, Wikipedia:Merkel_cell]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "MC" RELATED OMO:0003000 [PMID:24862916]
synonym: "Merkel's cell" EXACT []
xref: FMA:70548
xref: ZFA:0009146 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata)
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:1100001 ! secretory epithelial cell
relationship: capable_of GO:0007269 ! neurotransmitter secretion
relationship: has_part GO:0031201 ! SNARE complex
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000244
name: transitional epithelial cell
def: "A cell characteristically found lining hollow organs that are subject to great mechanical change due to contraction and distention; originally thought to represent a transition between stratified squamous and columnar epithelium." [GOC:tfm, ISBN:0721662544]
subset: human_reference_atlas
xref: FMA:66778
xref: ZFA:0009148 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000066 ! epithelial cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000255
name: eukaryotic cell
def: "Any cell that in taxon some Eukaryota." [FBC:Autogenerated]
xref: MESH:D005057
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: in_taxon NCBITaxon:2759 ! Eukaryota
relationship: in_taxon NCBITaxon:2759 ! Eukaryota
[Term]
id: CL:0000287
name: eye photoreceptor cell
def: "Any photoreceptor cell that is part of some eye." [FBC:Autogenerated]
subset: cellxgene_subset
subset: eye_upper_slim
subset: human_reference_atlas
xref: ZFA:0009154 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000210 ! photoreceptor cell
intersection_of: CL:0000210 ! photoreceptor cell
intersection_of: part_of UBERON:0000970 ! eye
relationship: part_of UBERON:0000970 ! eye
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000287" xsd:string {name="eye photoreceptor cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000295
name: somatotropin secreting cell
def: "A peptide hormone secreting cell that produces growth hormone, somatotropin." [GOC:tfm, SANBI:mhl]
synonym: "growth hormone secreting cell" EXACT []
synonym: "somatotrophin secreting cell" EXACT []
xref: ZFA:0009155 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0030252 ! growth hormone secretion
relationship: capable_of GO:0030252 ! growth hormone secretion
[Term]
id: CL:0000300
name: gamete
def: "A mature sexual reproductive cell having a single set of unpaired chromosomes." [GOC:tfm, ISBN:0721662544]
synonym: "haploid germ cell" RELATED []
synonym: "haploid nucleated cell" EXACT []
xref: CALOHA:TS-0395
xref: FBbt:00005412 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
xref: FMA:18649
xref: ZFA:0009156 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000413 ! haploid cell
is_a: CL:0000586 {is_inferred="true"} ! germ cell
intersection_of: CL:0000586 ! germ cell
intersection_of: capable_of GO:0009566 ! fertilization
intersection_of: RO:0000053 PATO:0001375 ! has characteristic haploid
relationship: capable_of GO:0009566 ! fertilization
relationship: RO:0000053 PATO:0001375 ! has characteristic haploid
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000300" xsd:string {name="gamete on CELLxGENE CellGuide"}
[Term]
id: CL:0000306
name: crystallin accumulating cell
subset: eye_upper_slim
synonym: "lens cell" EXACT []
is_a: CL:0000325 ! stuff accumulating cell
[Term]
id: CL:0000307
name: tracheal epithelial cell
def: "An epithelial cell found in the trachea." [GOC:tfm]
comment: This class is for the vertebrate tracheal structure. For the analagous insect cell type, see 'respiratory tube epithelial cell'
synonym: "tracheocyte" EXACT []
xref: FMA:74793
is_a: CL:0002202 {is_inferred="true"} ! epithelial cell of tracheobronchial tree
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0003126 ! trachea
relationship: develops_from CL:0000377 ! tracheoblast
relationship: part_of UBERON:0003126 ! trachea
[Term]
id: CL:0000311
name: keratin accumulating cell
xref: ZFA:0009157 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000325 ! stuff accumulating cell
[Term]
id: CL:0000312
name: keratinocyte
def: "An epithelial cell of stratified squamous tissues, including skin, oral mucosa (Hiroshima et al., 2011), and esophagus (Whelan et al., 2018), that produces keratin proteins and secretes antimicrobial peptides to form a resilient barrier against environmental damage, dehydration, pathogens, and microbial invasion. It undergoes successive stages of differentiation marked by changes in keratin expression, supporting tissue integrity, wound repair, and contributing to immune defense." [PMID:15749908, PMID:19256306, PMID:19727116, PMID:29713660, PMID:37873034]
subset: cellxgene_subset
subset: human_reference_atlas
xref: BTO:0000667
xref: CALOHA:TS-0500
xref: FMA:62879
xref: ZFA:0009158 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000237 {is_inferred="true"} ! keratinizing barrier epithelial cell
relationship: capable_of GO:0002775 ! antimicrobial peptide production
relationship: capable_of GO:0002776 ! antimicrobial peptide secretion
relationship: capable_of GO:0042060 ! wound healing
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000313
name: serous secreting cell
def: "Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid." [GOC:tfm, ISBN:0517223651, ISBN:0721662544]
subset: cellxgene_subset
synonym: "serous cell" EXACT []
xref: BTO:0003687
xref: FMA:62511
is_a: CL:0000159 ! seromucus secreting cell
[Term]
id: CL:0000314
name: milk secreting cell
is_a: CL:0000151 ! secretory cell
[Term]
id: CL:0000317
name: sebocyte
def: "An epithelial cell that is part of a sebaceous gland. This cell produces and secretes sebum, an oily, lipid-rich substance, through holocrine secretion where the entire cell ruptures to release its contents." [MESH:D012629, PMID:19944183]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "sebum secreting cell" EXACT []
is_a: CL:0000150 ! glandular secretory epithelial cell
is_a: CL:0000152 ! exocrine cell
is_a: CL:0000362 ! epidermal cell
is_a: CL:0002308 ! epithelial cell of skin gland
is_a: CL:2000021 ! sebaceous gland cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001821 ! sebaceous gland
relationship: part_of UBERON:0001821 ! sebaceous gland
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000319
name: mucus secreting cell
def: "Any cell that is capable of some mucus secretion." [FBC:Autogenerated]
subset: cellxgene_subset
synonym: "mucous cell" EXACT []
xref: BTO:0003689
xref: ZFA:0009159 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000159 ! seromucus secreting cell
intersection_of: CL:0000000 ! cell
intersection_of: capable_of GO:0070254 ! mucus secretion
relationship: capable_of GO:0070254 ! mucus secretion
[Term]
id: CL:0000322
name: pulmonary alveolar epithelial cell
def: "An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates." [GOC:tfm, PMID:20054144, PMID:29463737]
subset: cellxgene_subset
synonym: "alveolar epithelial cell" EXACT []
synonym: "alveolus of lung epithelial cell" EXACT []
synonym: "epithelial cell of alveolus of lung" EXACT []
synonym: "pneumocyte" EXACT [PMID:32491474]
synonym: "pneumonocyte" EXACT []
xref: BTO:0000395
xref: CALOHA:TS-2168
xref: FMA:62499
xref: MESH:D056809
is_a: CL:0000082 ! epithelial cell of lung
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0004821 ! pulmonary alveolus epithelium
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: part_of UBERON:0004821 ! pulmonary alveolus epithelium
property_value: dcterms-date "2024-09-02T08:27:21Z" xsd:dateTime
[Term]
id: CL:0000325
name: stuff accumulating cell
def: "A cell that is specialised to accumulate a particular substance(s)." [FB:ma]
subset: ubprop:upper_level
is_a: CL:0000000 ! cell
[Term]
id: CL:0000327
name: extracellular matrix secreting cell
subset: cellxgene_subset
xref: ZFA:0009162 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000499 ! stromal cell
[Term]
id: CL:0000329
name: oxygen accumulating cell
def: "Any cell that is capable of some oxygen transport." [FBC:Autogenerated]
xref: ZFA:0009164 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: capable_of GO:0015671 ! oxygen transport
relationship: capable_of GO:0015671 ! oxygen transport
[Term]
id: CL:0000333
name: migratory neural crest cell
def: "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body." [doi:10.1016/j.stem.2015.02.017]
xref: FMA:86667
xref: ZFA:0007086 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000219 ! motile cell
is_a: CL:0011012 ! neural crest cell
is_a: CL:0011026 ! progenitor cell
relationship: develops_from CL:0007004 ! premigratory neural crest cell
[Term]
id: CL:0000335
name: mesenchyme condensation cell
def: "A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors." [GOC:tfm, PMID:5025404]
subset: cellxgene_subset
xref: ZFA:0009166 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0008019 ! mesenchymal cell
[Term]
id: CL:0000336
name: adrenal medulla chromaffin cell
def: "A cell found within the adrenal medulla that secrete biogenic amine hormones upon stimulation." [GOC:tfm, http://www.britannica.com/EBchecked/topic/6405/adrenal-gland]
synonym: "medullary chromaffin cell of adrenal gland" EXACT [FMA:69262]
xref: FMA:69262
xref: ZFA:0009167 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000457 ! biogenic amine secreting cell
is_a: CL:1000426 ! chromaffin cell of adrenal gland
intersection_of: CL:0000166 ! chromaffin cell
intersection_of: part_of UBERON:0001236 ! adrenal medulla
relationship: develops_from CL:0000011 ! migratory trunk neural crest cell
relationship: part_of UBERON:0001236 ! adrenal medulla
[Term]
id: CL:0000339
name: glioblast (sensu Vertebrata)
def: "An early neural cell developing from the early ependymal cell of the neural tube." [GOC:tfm, ISBN:0618947256]
subset: cellxgene_subset
synonym: "spongioblast" EXACT []
xref: FMA:70564
xref: ZFA:0009169 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000030 ! glioblast
is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata)
[Term]
id: CL:0000346
name: hair follicle dermal papilla cell
def: "A specialized fibroblast that resides in the dermal papilla located at the bottom of hair follicles. This cell orchestrates reciprocal epithelial-mesenchymal signaling essential for hair follicle morphogenesis and cycling, regulating matrix cell proliferation and differentiation to control hair shaft size, shape, and growth. The dermal papilla cell is replenished each hair cycle from bipotent hair follicle dermal stem cells in the dermal sheath that simultaneously self-renew and contribute progeny to the papilla, particularly during anagen." [PMID:28418596, PMID:39798934, PMID:40867641]
comment: The dermal papilla contains functionally heterogeneous Sox2-positive subpopulations that serve as a niche for multipotent stem cells. These cells exhibit progenitor properties, generate skin-derived precursors (SKPs), and can differentiate into adipogenic and osteogenic lineages. {xref="PMID:21444748"}
synonym: "hair follicle DPC" RELATED OMO:0003000 [PMID:39798934]
is_a: CL:1000302 ! fibroblast of papillary layer of dermis
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0000412 ! dermal papilla
relationship: capable_of GO:0042634 ! regulation of hair cycle
relationship: capable_of GO:0060638 ! mesenchymal-epithelial cell signaling
relationship: part_of UBERON:0000412 ! dermal papilla
relationship: RO:0002596 GO:0031069 ! capable of regulating hair follicle morphogenesis
[Term]
id: CL:0000347
name: scleral cell
def: "A cell of the sclera of the eye." [GOC:add]
subset: eye_upper_slim
xref: ZFA:0009174 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0001773 ! sclera
relationship: develops_from CL:0000008 ! migratory cranial neural crest cell
relationship: part_of UBERON:0001773 ! sclera
[Term]
id: CL:0000348
name: choroidal cell of the eye
def: "A cell that is part of optic choroid." [GOC:add]
subset: eye_upper_slim
xref: ZFA:0009175 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0001776 ! optic choroid
relationship: develops_from CL:0000008 ! migratory cranial neural crest cell
relationship: part_of UBERON:0001776 ! optic choroid
[Term]
id: CL:0000349
name: extraembryonic cell
def: "Any cell that is part of some extraembryonic structure." [FBC:Autogenerated]
subset: cellxgene_subset
subset: general_cell_types_upper_slim
xref: ZFA:0009176 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0000478 ! extraembryonic structure
relationship: part_of UBERON:0000478 ! extraembryonic structure
[Term]
id: CL:0000350
name: amnioserosal cell
def: "Any extraembryonic cell that is part of some amnioserosa." [FBC:Autogenerated]
is_a: CL:0000349 ! extraembryonic cell
intersection_of: CL:0000349 ! extraembryonic cell
intersection_of: part_of UBERON:0010302 ! amnioserosa
relationship: part_of UBERON:0010302 ! amnioserosa
[Term]
id: CL:0000351
name: trophoblast cell
def: "An extraembryonic cell that develops from a trophectodermal cell. This cell is found in the outer layer of the blastocyst and can invade other structures in the uterus once the blastocyst implants into the uterine wall. A trophoblast cell is involved in the implantation of the embryo into the uterine wall, placental formation, remodelling of maternal vasculature in the uterus, nutrient and gas exchange, hormone production, and immune modulation to support fetal development." [doi:10.1007/978-3-030-84725-8, GOC:tfm, MESH:D014327, PMID:37630754]
synonym: "trophoblastic cell" EXACT [doi:10.1007/978-3-030-84725-8]
xref: FMA:83028
is_a: CL:0000349 {is_inferred="true"} ! extraembryonic cell
relationship: develops_from CL:1000274 ! trophectodermal cell
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000351" xsd:string {name="trophoblast cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000352
name: epiblast cell
def: "A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation." [GOC:tfm, ISBN:0618947256]
is_a: CL:0000052 ! totipotent stem cell
[Term]
id: CL:0000353
name: blastoderm cell
def: "An undifferentiated cell produced by early cleavages of the fertilized egg (zygote)." [MESH:D001756]
synonym: "blastomere" EXACT []
xref: BTO:0001473
xref: FMA:72551
xref: ZFA:0009177 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000007 ! early embryonic cell (metazoa)
[Term]
id: CL:0000354
name: blastemal cell
synonym: "blastema cell" EXACT []
xref: ncithesaurus:Blastemal_Cell
xref: ZFA:0009178 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000048 ! multi fate stem cell
[Term]
id: CL:0000355
name: multi-potent skeletal muscle stem cell
def: "A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell." [PMID:18282570]
comment: Multi-potency demonstrated ex vivo. At the time of writing, it is unclear whether the endogenous population differentiates into multiple cell types in vivo.
xref: FMA:86767
xref: ZFA:0009179 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell
is_a: CL:0000188 ! cell of skeletal muscle
intersection_of: CL:0000048 ! multi fate stem cell
intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue
relationship: part_of UBERON:0001134 ! skeletal muscle tissue
[Term]
id: CL:0000357
name: stratified epithelial stem cell
xref: ZFA:0009180 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000036 ! epithelial fate stem cell
[Term]
id: CL:0000358
name: sphincter associated smooth muscle cell
def: "A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning." [GOC:cjm]
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0004590 ! sphincter muscle
relationship: part_of UBERON:0004590 ! sphincter muscle
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000358" xsd:string {name="sphincter associated smooth muscle cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000359
name: vascular associated smooth muscle cell
def: "A smooth muscle cell associated with the vasculature." [GOC:dsd, GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "vascular smooth muscle cell" EXACT []
synonym: "VSMC" EXACT []
xref: ZFA:0009181 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
is_a: CL:4033054 ! perivascular cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0002049 ! vasculature
relationship: part_of UBERON:0002049 ! vasculature
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000359" xsd:string {name="vascular associated smooth muscle cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000361
name: gastrula cell
def: "A cell of the embryo in the early stage following the blastula, characterized by morphogenetic cell movements, cell differentiation, and the formation of the three germ layers." [MESH:D005775]
xref: ZFA:0009182 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000007 ! early embryonic cell (metazoa)
is_a: CL:0000255 ! eukaryotic cell
relationship: part_of UBERON:0004734 ! gastrula
[Term]
id: CL:0000362
name: epidermal cell
def: "An epithelial cell of the integument (the outer layer of an organism)." [Flybase:dsj, MA:ma]
subset: cellxgene_subset
synonym: "cell of epidermis" EXACT [FMA:62411]
synonym: "epithelial cell of skin" NARROW [FMA:62411]
xref: BTO:0001470
xref: CALOHA:TS-0283
xref: FMA:62411
xref: MESH:D000078404
xref: ZFA:0009183 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0002159 ! general ecto-epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0007376 ! outer epithelium
relationship: part_of UBERON:0007376 ! outer epithelium
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000362" xsd:string {name="epidermal cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000365
name: animal zygote
def: "Diploid cell produced by the fusion of sperm cell nucleus and egg cell." [ISBN:0471245208]
synonym: "zygote" BROAD []
xref: BTO:0000854
xref: EHDAA2:0004546
xref: FMA:72395
is_a: CL:0000007 ! early embryonic cell (metazoa)
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0010017 ! zygote
intersection_of: CL:0010017 ! zygote
intersection_of: in_taxon NCBITaxon:33208 ! Metazoa
relationship: in_taxon NCBITaxon:33208 ! Metazoa
[Term]
id: CL:0000373
name: histoblast
def: "A progenitor cell found in the larval epidermis of insects and that gives rise to the adult abdominal epidermis." [doi:10.1016/j.cub.2022.01.045]
xref: FBbt:00001789 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
is_a: CL:0011026 ! progenitor cell
relationship: in_taxon NCBITaxon:50557 ! Insecta
[Term]
id: CL:0000377
name: tracheoblast
is_a: CL:0000069 ! branched duct epithelial cell
[Term]
id: CL:0000385
name: prohemocyte (sensu Nematoda and Protostomia)
def: "A precursor of mature hemocytes." [doi:10.1016/B978-012369493-5.50008-0]
xref: FBbt:00005062 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
is_a: CL:0008001 ! hematopoietic precursor cell
relationship: never_in_taxon NCBITaxon:33511 ! Deuterostomia
[Term]
id: CL:0000387
name: hemocyte (sensu Arthropoda)
def: "A blood cell of the circulatory system of arthropods." [doi:10.1016/B978-012369493-5.50008-0]
xref: FBbt:00005063 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000390 ! blood cell (sensu Nematoda and Protostomia)
relationship: develops_from CL:0000385 ! prohemocyte (sensu Nematoda and Protostomia)
relationship: in_taxon NCBITaxon:6656 ! Arthropoda
[Term]
id: CL:0000388
name: tendon cell
def: "An elongated fibroblast that is part of a tendon. Its cytoplasm is stretched between the collagen fibres of the tendon, and it possesses a central nucleus with a prominent nucleolus. Tendon cell has a well-developed rough endoplasmic reticulum, and it is responsible for the synthesis and turnover of tendon fibres and ground substance." [GOC:NV, GOC:tfm, PMID:37894875, PMID:957445]
subset: cellxgene_subset
synonym: "muscle attachment cell" EXACT []
synonym: "tenocyte" RELATED []
xref: ZFA:0009189 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:1000307 ! fibroblast of dense regular elastic tissue
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0000043 ! tendon
relationship: part_of UBERON:0000043 ! tendon
[Term]
id: CL:0000390
name: blood cell (sensu Nematoda and Protostomia)
is_a: CL:0000081 ! blood cell
relationship: never_in_taxon NCBITaxon:33511 ! Deuterostomia
[Term]
id: CL:0000393
name: electrically responsive cell
def: "A cell whose function is determined by its response to an electric signal." [FB:ma]
xref: ZFA:0009190 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000211 ! electrically active cell
[Term]
id: CL:0000397
name: ganglion interneuron
def: "Any interneuron that has its soma located in some ganglion." [FBC:Autogenerated]
subset: cellxgene_subset
is_a: CL:0000099 {is_inferred="true"} ! interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0002100 UBERON:0000045 ! has soma location ganglion
relationship: RO:0002100 UBERON:0000045 ! has soma location ganglion
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000397" xsd:string {name="ganglion interneuron on CELLxGENE CellGuide"}
[Term]
id: CL:0000404
name: electrically signaling cell
def: "A cell that initiates an electrical signal and passes that signal to another cell." [FB:ma]
xref: ZFA:0009193 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000211 ! electrically active cell
[Term]
id: CL:0000408
name: male gamete
def: "Any male germ cell that has characteristic some haploid and is capable of some fertilization." [FBC:Autogenerated]
xref: BTO:0001277
xref: CALOHA:TS-0949
is_a: CL:0000015 {is_inferred="true"} ! male germ cell
is_a: CL:0000300 {is_inferred="true"} ! gamete
intersection_of: CL:0000015 ! male germ cell
intersection_of: capable_of GO:0009566 ! fertilization
intersection_of: RO:0000053 PATO:0001375 ! has characteristic haploid
relationship: capable_of GO:0009566 ! fertilization
relationship: RO:0000053 PATO:0001375 ! has characteristic haploid
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000408" xsd:string {name="male gamete on CELLxGENE CellGuide"}
[Term]
id: CL:0000412
name: polyploid cell
def: "A cell that contains more than two haploid sets of chromosomes." [FB:ma, https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Biology_(Kimball)/07%3A_Cell_Division/7.04%3A_Polyploidy, PMID:32646579]
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0000053 PATO:0001377 ! has characteristic polyploid
relationship: RO:0000053 PATO:0001377 ! has characteristic polyploid
[Term]
id: CL:0000413
name: haploid cell
def: "A cell whose nucleus contains a single haploid genome." [FB:ma, GOC:tfm]
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0000053 PATO:0001375 ! has characteristic haploid
relationship: RO:0000053 PATO:0001375 ! has characteristic haploid
[Term]
id: CL:0000417
name: endopolyploid cell
is_a: CL:0000412 ! polyploid cell
[Term]
id: CL:0000424
name: excretory cell
def: "A cell involved in the elimination of metabolic and foreign toxins, and in maintaining the ionic, acid-base and water balance of biological fluids." [GOC:tfm, PMID:19783135]
xref: WBbt:0005812
is_a: CL:0000000 ! cell
[Term]
id: CL:0000430
name: xanthophore cell
def: "A pigment cell derived from the neural crest. Contains cartenoid pigments in structures called pterinosomes or xanthosomes. This gives an appearance ranging from a golden yellow to orange and red." [SANBI:mhl]
synonym: "xanthophore" RELATED []
xref: ZFA:0009198 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000147 ! pigment cell
is_a: CL:0000255 ! eukaryotic cell
relationship: develops_from CL:0005002 ! xanthoblast
[Term]
id: CL:0000431
name: iridophore
def: "A pigment cell derived from the neural crest. The cell contains flat light-reflecting platelets, probably of guanine, in stacks called reflecting platelets or iridisomes. The color-generating components produce a silver, gold, or iridescent color." [SANBI:mhl]
synonym: "guanophore" RELATED []
xref: ZFA:0009199 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000147 ! pigment cell
is_a: CL:0000255 ! eukaryotic cell
relationship: develops_from CL:0005001 ! iridoblast
[Term]
id: CL:0000432
name: reticular cell
def: "A fibroblast that synthesizes collagen and uses it to produce reticular fibers, thus providing structural support. Reticular cells are found in many organs, including the spleen, lymph nodes and kidneys. Subtypes of reticular cells include epithelial, mesenchymal, and fibroblastic reticular cells. Fibroblastic reticular cells are involved in directing B cells and T cells to specific regions within a tissue, whereas epithelial and mesenchymal reticular cells are associated with certain areas of the brain." [GOC:tfm, http://en.wikipedia.org/wiki/Reticular_cell, ISBN:0517223651]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "reticulum cell" EXACT []
xref: FMA:62877
xref: ZFA:0009200 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000057 ! fibroblast
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/1472" xsd:string
[Term]
id: CL:0000438
name: luteinizing hormone secreting cell
def: "A peptide hormone secreting cell pituitary that produces luteinizing hormone." [GOC:tfm]
xref: ZFA:0009203 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0032275 ! luteinizing hormone secretion
relationship: capable_of GO:0032275 ! luteinizing hormone secretion
[Term]
id: CL:0000439
name: prolactin secreting cell
def: "A peptide hormone cell that secretes prolactin." [GOC:tfm, SANBI:mhl]
xref: ZFA:0009204 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000154 ! protein secreting cell
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0070459 ! prolactin secretion
relationship: capable_of GO:0070459 ! prolactin secretion
[Term]
id: CL:0000440
name: melanocyte stimulating hormone secreting cell
def: "A cell of the intermediate pituitary that produces melanocyte stimulating hormone." [SANBI:mhl]
synonym: "melanotrope" EXACT []
synonym: "melanotroph" EXACT []
xref: BTO:0002277
xref: ZFA:0009205 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0036160 ! melanocyte-stimulating hormone secretion
relationship: capable_of GO:0036160 ! melanocyte-stimulating hormone secretion
[Term]
id: CL:0000441
name: follicle stem cell (sensu Arthropoda)
def: "A stem cell that gives rise to the follicle cells that surround the oocyte in female arthropods." [doi:10.1016/B978-012369493-5.50005-5, doi:10.1038/s41467-020-19361-0, doi:10.1242/dev.121.11.3797]
synonym: "somatic stem cell" BROAD [doi:10.1016/j.devcel.2005.08.012]
xref: FBbt:00004903 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
is_a: CL:0000036 ! epithelial fate stem cell
relationship: in_taxon NCBITaxon:6656 {IAO:0000233="https://github.com/obophenotype/cell-ontology/issues/1943"} ! Arthropoda
[Term]
id: CL:0000443
name: calcitonin secreting cell
def: "Any secretory cell that is capable of some calcitonin secretion." [FBC:Autogenerated]
xref: ZFA:0009206 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0036161 ! calcitonin secretion
relationship: capable_of GO:0036161 ! calcitonin secretion
[Term]
id: CL:0000444
name: obliquely striated muscle cell
def: "A muscle cell in which the fibers are organised into sarcomeres but in which adjacent myofibrils are offset from each other, producing an oblique banding pattern." [GOC:DOS, PMID:8720463]
comment: Examples include the somatic muscles of nemotodes and cephalopods.
is_a: CL:0000737 ! striated muscle cell
intersection_of: CL:0000187 ! muscle cell
intersection_of: has_part GO:0030017 ! sarcomere
intersection_of: RO:0000053 PATO:0002479 ! has characteristic obliquely striated
relationship: has_part GO:0030017 ! sarcomere
relationship: RO:0000053 PATO:0002479 ! has characteristic obliquely striated
[Term]
id: CL:0000446
name: chief cell of parathyroid gland
def: "An epithelial cell of the parathyroid gland that is arranged in wide, irregular interconnecting columns; responsible for the synthesis and secretion of parathyroid hormone." [FMA:69078, GOC:tfm, ISBN:0517223651]
synonym: "parathyroid chief cell" EXACT []
synonym: "parathyroid gland chief cell" EXACT []
synonym: "parathyroid hormone secreting cell" EXACT []
synonym: "principal cell of parathyroid gland" EXACT []
xref: BTO:0004712
xref: CALOHA:TS-2140
xref: FMA:69078
is_a: CL:1001593 ! parathyroid glandular cell
relationship: capable_of GO:0035898 ! parathyroid hormone secretion
relationship: part_of UBERON:0011197 ! parathyroid epithelium
[Term]
id: CL:0000447
name: carbohydrate secreting cell
is_a: CL:0000151 ! secretory cell
[Term]
id: CL:0000448
name: white adipocyte
def: "An adipocyte with light coloration and few mitochondria. It contains a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole." [GOC:tfm, MESH:D052438]
synonym: "white adipose cell" EXACT []
synonym: "white fat cell" RELATED []
xref: CALOHA:TS-1119
xref: FMA:83434
is_a: CL:0000136 ! adipocyte
relationship: develops_from CL:0002334 ! preadipocyte
relationship: part_of UBERON:0001347 ! white adipose tissue
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000448" xsd:string {name="white adipocyte on CELLxGENE CellGuide"}
[Term]
id: CL:0000449
name: brown adipocyte
def: "A cell from the thermogenic form of adipose tissue found in many species, particularly in newborns and hibernating mammals, but also in lesser amounts in adults of other mammals including humans. Brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation." [MESH:D002001]
subset: cellxgene_subset
synonym: "brown adipose cell" EXACT []
synonym: "brown fat cell" EXACT []
xref: CALOHA:TS-0099
xref: FMA:83435
is_a: CL:0000136 ! adipocyte
relationship: develops_from CL:0002335 ! brown preadipocyte
relationship: part_of UBERON:0001348 ! brown adipose tissue
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000449" xsd:string {name="brown adipocyte on CELLxGENE CellGuide"}
[Term]
id: CL:0000451
name: dendritic cell
def: "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative)." [GOC:add, ISBN:0781735149]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "interdigitating cell" RELATED []
synonym: "veiled cell" RELATED []
xref: BTO:0002042
xref: CALOHA:TS-0194
xref: FMA:83036
xref: MESH:D003713
xref: ZFA:0009209 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000113 ! mononuclear phagocyte
is_a: CL:0000145 ! professional antigen presenting cell
intersection_of: CL:0000738 ! leukocyte
intersection_of: capable_of GO:0001816 ! cytokine production
intersection_of: capable_of GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
intersection_of: capable_of GO:0019882 ! antigen processing and presentation
intersection_of: capable_of GO:0045580 ! regulation of T cell differentiation
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: has_part GO:0042613 ! MHC class II protein complex
intersection_of: RO:0000053 PATO:0001407 ! has characteristic mononucleate
disjoint_from: CL:0000542 ! lymphocyte
relationship: capable_of GO:0001816 ! cytokine production
relationship: capable_of GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
relationship: capable_of GO:0019882 ! antigen processing and presentation
relationship: capable_of GO:0045580 ! regulation of T cell differentiation
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: has_part GO:0042613 ! MHC class II protein complex
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0000053 PATO:0001407 ! has characteristic mononucleate
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000451" xsd:string {name="dendritic cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000453
name: Langerhans cell
def: "Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus." [GO_REF:0000031, GOC:add, GOC:amm, ISBN:0721601464, ISBN:0781735149, PMCID:PMC2346585, PMID:17850486]
comment: Originally described in the dendritic cell ontology (DC_CL:0000021 )(PMID:19243617). These cells are also CD1a-high, CD14-negative, CD207-positive (langerin), CD324-positive (E-cadherin), and DCIR-positive. They reside in the epidermis.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "LC" EXACT []
xref: BTO:0000705
xref: CALOHA:TS-2375
xref: FMA:63072
xref: MESH:D007801
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: capable_of GO:0002828 ! regulation of type 2 immune response
intersection_of: RO:0002104 PR:000001293 ! has plasma membrane part C-type lectin domain family 4 member K
relationship: capable_of GO:0002828 ! regulation of type 2 immune response
relationship: develops_from CL:0000763 ! myeloid cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 PR:000001293 ! has plasma membrane part C-type lectin domain family 4 member K
[Term]
id: CL:0000454
name: epinephrine secreting cell
def: "A cell capable of producing epinephrine. Epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme, which is expressed in the adrenal glands, androgenic neurons, and in other cell types." [GOC:tfm, PMID:12438093]
synonym: "adrenaline secreting cell" EXACT [GO:0048242]
synonym: "epinephrin secreting cell" EXACT []
xref: ZFA:0009211 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000457 ! biogenic amine secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0048242 ! epinephrine secretion
relationship: capable_of GO:0048242 ! epinephrine secretion
[Term]
id: CL:0000456
name: mineralocorticoid secreting cell
def: "Any secretory cell that is capable of some mineralocorticoid secretion." [FBC:Autogenerated]
is_a: CL:0000174 ! steroid hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0035931 ! mineralocorticoid secretion
relationship: capable_of GO:0035931 ! mineralocorticoid secretion
[Term]
id: CL:0000457
name: biogenic amine secreting cell
xref: ZFA:0009212 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000151 ! secretory cell
[Term]
id: CL:0000458
name: serotonin secreting cell
def: "A cell type that secretes 5-Hydroxytryptamine (serotonin)." [GOC:tfm, PMID:19630576]
synonym: "5-HT secreting cell" EXACT []
synonym: "5-Hydroxytryptamine secreting cell" EXACT []
xref: ZFA:0009213 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000457 ! biogenic amine secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0001820 ! serotonin secretion
relationship: capable_of GO:0001820 ! serotonin secretion
[Term]
id: CL:0000459
name: noradrenergic cell
def: "A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme." [GOC:tfm, ISBN:068340007X]
subset: cellxgene_subset
synonym: "noradrenaline secreting cell" EXACT []
synonym: "norepinephrin secreting cell" EXACT []
synonym: "norepinephrine secreting cell" EXACT []
xref: ZFA:0009214 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000457 ! biogenic amine secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0048243 ! norepinephrine secretion
relationship: capable_of GO:0048243 ! norepinephrine secretion
[Term]
id: CL:0000460
name: glucocorticoid secreting cell
def: "Any secretory cell that is capable of some glucocorticoid secretion." [FBC:Autogenerated]
xref: ZFA:0009215 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000174 ! steroid hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0035933 ! glucocorticoid secretion
relationship: capable_of GO:0035933 ! glucocorticoid secretion
[Term]
id: CL:0000467
name: adrenocorticotropic hormone secreting cell
def: "A peptide hormone secreting cell that produces adrenocorticotropin, or corticotropin." [GOC:tfm, SANBI:mhl]
synonym: "ACTH secreting cell" EXACT [GO:0051458]
synonym: "adrenocorticotrophic hormone secreting cell" EXACT []
synonym: "corticotrophin hormone secreting cell" EXACT []
synonym: "corticotropin hormone secreting cell" EXACT []
synonym: "corticotropin secreting cell" EXACT [GO:0051458]
xref: ZFA:0009216 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0051458 ! corticotropin secretion
relationship: capable_of GO:0051458 ! corticotropin secretion
[Term]
id: CL:0000477
name: follicle cell of egg chamber
def: "A somatic epithelial cell of the insect egg chamber." []
synonym: "follicle cell" BROAD []
synonym: "ovarian follicle cell" BROAD []
xref: FBbt:00004904 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
is_a: CL:0000500 ! follicular epithelial cell
relationship: develops_from CL:0000441 ! follicle stem cell (sensu Arthropoda)
relationship: in_taxon NCBITaxon:50557 {source="https://github.com/obophenotype/cell-ontology/issues/589"} ! Insecta
relationship: part_of UBERON:0000992 ! ovary
[Term]
id: CL:0000482
name: juvenile hormone secreting cell
def: "An endocrine cell that secretes juvenile hormone." [GO:tfm]
xref: FBbt:00058020 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0045443 ! juvenile hormone secretion
relationship: capable_of GO:0045443 ! juvenile hormone secretion
[Term]
id: CL:0000488
name: visible light photoreceptor cell
def: "A photoreceptor cell that detects visible light." [GOC:tfm]
xref: ZFA:0009219 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000210 ! photoreceptor cell
intersection_of: CL:0000210 ! photoreceptor cell
intersection_of: capable_of GO:0009584 ! detection of visible light
relationship: capable_of GO:0009584 ! detection of visible light
[Term]
id: CL:0000498
name: inhibitory interneuron
def: "An interneuron (also called relay neuron, association neuron or local circuit neuron) is a multipolar neuron which connects afferent neurons and efferent neurons in neural pathways. Like motor neurons, interneuron cell bodies are always located in the central nervous system (CNS)." [GOC:tfm, http://en.wikipedia.org/wiki/Interneuron]
subset: cellxgene_subset
xref: FMA:84776
xref: ZFA:0009225 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000099 ! interneuron
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000498" xsd:string {name="inhibitory interneuron on CELLxGENE CellGuide"}
[Term]
id: CL:0000499
name: stromal cell
def: "A connective tissue cell of an organ found in the loose connective tissue." [GOC:tfm, MESH:D017154]
subset: cellxgene_subset
subset: human_reference_atlas
xref: BTO:0002064
xref: FMA:83624
xref: ZFA:0009226 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0002320 ! connective tissue cell
relationship: develops_from CL:0000134 ! mesenchymal stem cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000499" xsd:string {name="stromal cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000500
name: follicular epithelial cell
def: "An epithelial somatic cell associated with a maturing oocyte." []
is_a: CL:0000066 ! epithelial cell
[Term]
id: CL:0000501
name: granulosa cell
def: "A supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors." [MESH:D006107]
subset: cellxgene_subset
synonym: "granulosa cell of ovary" EXACT []
xref: BTO:0000542
xref: CALOHA:TS-0729
xref: FMA:18718
xref: ZFA:0009227 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000174 ! steroid hormone secreting cell
is_a: CL:0002174 ! follicular cell of ovary
relationship: develops_from CL:4033066 ! pre-granulosa cell
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000501" xsd:string {name="granulosa cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000502
name: type D enteroendocrine cell
def: "A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin." [MESH:D019864]
subset: cellxgene_subset
synonym: "D cell" EXACT []
xref: FMA:62935
xref: ZFA:0009228 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000165 ! neuroendocrine cell
is_a: CL:0000172 ! somatostatin secreting cell
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000502" xsd:string {name="type D enteroendocrine cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000503
name: theca cell
def: "A specialized stromal cell that forms the theca layer outside the basal lamina lining the ovarian follicle, appearing during the secondary follicle stage." [MESH:D013799, PMID:15833266, PMID:36758341]
subset: cellxgene_subset
subset: human_reference_atlas
xref: BTO:0002850
xref: ZFA:0009229 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0002132 ! stromal cell of ovary
is_a: CL:0002174 ! follicular cell of ovary
relationship: part_of UBERON:0000155 ! theca cell layer
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000503" xsd:string {name="theca cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000506
name: enkephalin secreting cell
def: "An endorphine cell that secretes enkephalin." [GO:tfm]
xref: ZFA:0009231 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000507 ! endorphin secreting cell
[Term]
id: CL:0000507
name: endorphin secreting cell
def: "A peptide hormone secreting cell that secretes endorphin." [GO:tfm]
xref: ZFA:0009232 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000167 ! peptide hormone secreting cell
[Term]
id: CL:0000508
name: type G enteroendocrine cell
def: "An endocrine cell found in the stomach and duodenum and is responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli." [GOC:tfm, ISBN:0517223651, MESH:D019863, PMID:10700044, PMID:35674015, PMID:37240181]
subset: cellxgene_subset
synonym: "G cell" EXACT []
xref: BTO:0004108
xref: FMA:67609
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000165 ! neuroendocrine cell
is_a: CL:0000506 ! enkephalin secreting cell
is_a: CL:0000509 ! gastrin secreting cell
[Term]
id: CL:0000509
name: gastrin secreting cell
def: "A peptide hormone secreting cell that secretes gastrin." [GO:tfm]
subset: human_reference_atlas
is_a: CL:0000167 ! peptide hormone secreting cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000511
name: androgen binding protein secreting cell
def: "A peptide hormone secreting cell that secretes androgen binding protein." [GO:tfm]
is_a: CL:0000154 ! protein secreting cell
[Term]
id: CL:0000513
name: cardiac muscle myoblast
def: "A precursor cell destined to differentiate into cardiac muscle cell." [GOC:tfm, MESH:D032386]
subset: cellxgene_subset
synonym: "cardiac muscle progenitor cell" EXACT []
synonym: "cardiomyocyte progenitor cell" EXACT []
xref: FMA:84797
xref: ZFA:0009234 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0002494 ! cardiocyte
is_a: CL:0010021 ! cardiac myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: develops_into CL:0000746 ! cardiac muscle cell
intersection_of: part_of UBERON:0001133 ! cardiac muscle tissue
relationship: develops_into CL:0000746 ! cardiac muscle cell
relationship: part_of UBERON:0001133 ! cardiac muscle tissue
[Term]
id: CL:0000514
name: smooth muscle myoblast
def: "A precursor cell destined to differentiate into smooth muscle myocytes." [GOC:tfm, MESH:D032390]
subset: cellxgene_subset
synonym: "myoblast, smooth muscle" EXACT [MESH:D032390]
synonym: "satellite cell" RELATED []
xref: FMA:84798
xref: ZFA:0009235 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000056 ! myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: develops_into CL:0000192 ! smooth muscle cell
relationship: develops_into CL:0000192 ! smooth muscle cell
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000514" xsd:string {name="smooth muscle myoblast on CELLxGENE CellGuide"}
[Term]
id: CL:0000515
name: skeletal muscle myoblast
def: "A myoblast that differentiates into skeletal muscle fibers." [SANBI:mhl]
subset: cellxgene_subset
synonym: "skeletal myoblast" EXACT []
xref: FMA:84799
xref: ZFA:0009236 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000056 ! myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: develops_into CL:0008002 ! skeletal muscle fiber
relationship: develops_from CL:0000355 ! multi-potent skeletal muscle stem cell
relationship: develops_into CL:0008002 ! skeletal muscle fiber
[Term]
id: CL:0000518
name: phagocyte (sensu Vertebrata)
def: "A phagocyte in vertebrates that is able to phagocytosis." [GOC:tfm]
is_a: CL:0000234 ! phagocyte
is_a: CL:0000255 ! eukaryotic cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
[Term]
id: CL:0000521
name: fungal cell
def: "Any cell that in taxon some Fungi." [FBC:Autogenerated]
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: in_taxon NCBITaxon:4751 ! Fungi
relationship: in_taxon NCBITaxon:4751 ! Fungi
[Term]
id: CL:0000525
name: syncytiotrophoblast cell
def: "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy." [GOC:tfm, ISBN:0323052908]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "plasmidotrophoblast cell" RELATED []
synonym: "syncytial trophoblast cell" EXACT [PMID:11787150]
synonym: "syncytiotrophoblastic cell" EXACT [PMID:21733368]
synonym: "syntrophoblast cell" RELATED []
xref: FMA:83043
is_a: CL:0000351 ! trophoblast cell
is_a: CL:4052002 ! syncytial cell
intersection_of: CL:0000351 ! trophoblast cell
intersection_of: RO:0000053 PATO:0001908 ! has characteristic multinucleate
relationship: part_of UBERON:0000371 ! syncytiotrophoblast
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0000053 PATO:0001908 ! has characteristic multinucleate
property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/2100" xsd:string
[Term]
id: CL:0000526
name: afferent neuron
def: "A neuron which conveys sensory information centrally from the periphery." [GOC:tfm, MESH:D009475]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "input neuron" EXACT []
xref: FMA:87653
xref: ZFA:0009238 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000540 ! neuron
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000527
name: efferent neuron
def: "A neuron which sends impulses peripherally to activate muscles or secretory cells." [MESH:D009476]
subset: cellxgene_subset
synonym: "output neuron" EXACT []
xref: ZFA:0009239 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000540 ! neuron
[Term]
id: CL:0000540
name: neuron
def: "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [http://en.wikipedia.org/wiki/Neuron, MESH:D009474]
comment: These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "nerve cell" EXACT []
xref: BTO:0000938
xref: CALOHA:TS-0683
xref: FBbt:00005106 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
xref: FMA:54527
xref: VHOG:0001483
xref: WBbt:0003679
xref: ZFA:0009248 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000393 ! electrically responsive cell
is_a: CL:0000404 ! electrically signaling cell
is_a: CL:0002319 ! neural cell
relationship: capable_of GO:0019226 ! transmission of nerve impulse
relationship: develops_from CL:0000031 {gci_relation="in_taxon", gci_filler="NCBITaxon:7742", xref="https://github.com/obophenotype/cell-ontology/issues/757"} ! neuroblast (sensu Vertebrata)
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: depiction "https://www.swissbiopics.org/api/image/Neuron_cells.svg" xsd:anyURI
[Term]
id: CL:0000541
name: melanoblast
def: "A cell that originates from the neural crest and differentiates into a pigment cell." [GOC:tfm, SANBI:mhl]
comment: Derived from UBERON:0002342 neural crest.
xref: BTO:0003217
xref: FMA:83377
xref: ZFA:0009249 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0011026 ! progenitor cell
relationship: develops_from CL:0000333 ! migratory neural crest cell
[Term]
id: CL:0000542
name: lymphocyte
def: "A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [GOC:add, ISBN:0683073696, ISBN:0781735149]
comment: Editors note: consider adding taxon constraint to vertebrata (PMID:18025161)
subset: cellxgene_subset
subset: human_reference_atlas
xref: BTO:0000775
xref: CALOHA:TS-0583
xref: FMA:62863
xref: MESH:D008214
xref: VHOG:0001535
xref: ZFA:0009250 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000842 ! mononuclear leukocyte
intersection_of: CL:0000738 ! leukocyte
intersection_of: has_part CL:0017500 ! neutrophillic cytoplasm
intersection_of: has_part GO:0000792 ! heterochromatin
intersection_of: RO:0000053 PATO:0001407 ! has characteristic mononucleate
intersection_of: RO:0000053 PATO:0040072 ! has characteristic high nuclear/cytoplasmic ratio
disjoint_from: CL:0000766 ! myeloid leukocyte
relationship: develops_from CL:0000051 ! common lymphoid progenitor
relationship: has_part CL:0017500 ! neutrophillic cytoplasm
relationship: has_part GO:0000792 ! heterochromatin
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0000053 PATO:0001407 ! has characteristic mononucleate
relationship: RO:0000053 PATO:0040072 ! has characteristic high nuclear/cytoplasmic ratio
[Term]
id: CL:0000547
name: proerythroblast
def: "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers." [ISBN:0721601464, PMID:1638021]
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
synonym: "pronormoblast" RELATED []
synonym: "rubriblast" EXACT [ISBN:0721601464]
xref: FMA:83518
is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000764 ! erythroid lineage cell
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
intersection_of: has_part CL:0017503 ! basophilic cytoplasm
intersection_of: has_part GO:0005730 ! nucleolus
intersection_of: RO:0000053 PATO:0002505 ! has characteristic nucleated
intersection_of: RO:0000053 PATO:0040072 ! has characteristic high nuclear/cytoplasmic ratio
intersection_of: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
relationship: develops_from CL:0000038 ! erythroid progenitor cell
relationship: has_part CL:0017503 ! basophilic cytoplasm
relationship: has_part GO:0005730 ! nucleolus
relationship: RO:0000053 PATO:0002505 ! has characteristic nucleated
relationship: RO:0000053 PATO:0040072 ! has characteristic high nuclear/cytoplasmic ratio
relationship: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1
[Term]
id: CL:0000549
name: basophilic erythroblast
def: "A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers." [GOC:tfm, ISBN:0721601464]
subset: cellxgene_subset
synonym: "basophilic normoblast" EXACT [ISBN:0721601464]
synonym: "early erythroblast" EXACT [ISBN:0721601464]
synonym: "early normoblast" EXACT [ISBN:0721601464]
synonym: "prorubricyte" EXACT [ISBN:0721601464]
xref: FMA:83505
xref: ZFA:0005236 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000765 {is_inferred="true"} ! erythroblast
intersection_of: CL:0000765 ! erythroblast
intersection_of: has_part CL:0017503 ! basophilic cytoplasm
intersection_of: has_part GO:0000792 ! heterochromatin
intersection_of: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1
relationship: has_part CL:0017503 ! basophilic cytoplasm
relationship: has_part GO:0000792 ! heterochromatin
relationship: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1
[Term]
id: CL:0000550
name: polychromatophilic erythroblast
def: "A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers." [ISBN:0721601464]
subset: cellxgene_subset
synonym: "intermediate erythroblast" EXACT [ISBN:0721601464]
synonym: "intermediate normoblast" EXACT [ISBN:0721601464]
synonym: "polychromatic erythroblast" EXACT [ISBN:0721601464]
synonym: "polychromatic normoblast" EXACT [ISBN:0721601464]
synonym: "polychromatophilic normoblast" EXACT [ISBN:0721601464]
synonym: "rubricyte" EXACT [ISBN:0721601464]
xref: FMA:83506
xref: ZFA:0005241 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000765 {is_inferred="true"} ! erythroblast
intersection_of: CL:0000765 ! erythroblast
intersection_of: has_part CL:0017504 ! polychromatophilic cytoplasm
intersection_of: has_part GO:0000792 ! heterochromatin
intersection_of: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1
relationship: develops_from CL:0000549 ! basophilic erythroblast
relationship: has_part CL:0017504 ! polychromatophilic cytoplasm
relationship: has_part GO:0000792 ! heterochromatin
relationship: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1
[Term]
id: CL:0000552
name: orthochromatic erythroblast
def: "The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated." [ISBN:0721601464]
subset: cellxgene_subset
synonym: "acidophilic erythroblast" EXACT [ISBN:0721601464]
synonym: "eosinophilic erythroblast" EXACT [ISBN:0721601464]
synonym: "late erythoblast" EXACT []
synonym: "orthochromatic normoblast" EXACT [ISBN:0721601464]
synonym: "pyknotic eto enrythroblast" EXACT [ISBN:0721601464]
xref: FMA:84646
is_a: CL:0000765 {is_inferred="true"} ! erythroblast
intersection_of: CL:0000765 ! erythroblast
intersection_of: has_part CL:0017502 ! acidophilic cytoplasm
intersection_of: participates_in GO:0030263 ! apoptotic chromosome condensation
relationship: develops_from CL:0000550 ! polychromatophilic erythroblast
relationship: has_part CL:0017502 ! acidophilic cytoplasm
relationship: participates_in GO:0030263 ! apoptotic chromosome condensation
[Term]
id: CL:0000553
name: megakaryocyte progenitor cell
def: "The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative)." [GOC:dsd, GOC:tfm, ISBN:0721601464]
comment: Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "CFU-Meg" EXACT [PMID:11722431, PMID:12482498]
synonym: "colony-forming unit-megakaryocyte" EXACT []
synonym: "Meg-CFC" EXACT [PMCID:PMC1794060]
synonym: "megacaryoblast" EXACT []
synonym: "megacaryocyte progenitor cell" EXACT []
synonym: "megakaryoblast" EXACT []
synonym: "megakaryocytic progenitor cell" EXACT [PMID:12482498]
synonym: "MkP" EXACT [PMID:21116988]
synonym: "promegacaryocyte" RELATED []
synonym: "promegakaryocyte" RELATED []
xref: BTO:0001164
xref: CALOHA:TS-0610
xref: FMA:84235
xref: MESH:D055016
is_a: CL:0000763 ! myeloid cell
is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell
intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: capable_of GO:0007113 ! endomitotic cell cycle
intersection_of: capable_of GO:0030219 ! megakaryocyte differentiation
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
relationship: capable_of GO:0007113 ! endomitotic cell cycle
relationship: capable_of GO:0030219 ! megakaryocyte differentiation
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
relationship: develops_from CL:0000050 ! megakaryocyte-erythroid progenitor cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000556
name: megakaryocyte
def: "A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release." [http://en.wikipedia.org/wiki/Megakaryocyte, ISBN:0721601464, MESH:D008533, PMID:31043076]
comment: Megakaryocytes are reportedly CD181-positive and CD182-positive.
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "megacaryocyte" EXACT []
synonym: "megalocaryocyte" EXACT []
synonym: "megalokaryocyte" EXACT []
xref: BTO:0000843
xref: CALOHA:TS-0611
xref: FMA:83555
is_a: CL:0000763 {is_inferred="true"} ! myeloid cell
disjoint_from: CL:0000764 ! erythroid lineage cell
relationship: develops_from CL:0000553 ! megakaryocyte progenitor cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0000053 PATO:0001393 ! has characteristic euploid
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000556" xsd:string {name="megakaryocyte on CELLxGENE CellGuide"}
[Term]
id: CL:0000557
name: granulocyte monocyte progenitor cell
def: "A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1." [GO_REF:0000031, GOC:amm, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/CFU-GM, http://www.copewithcytokines.de, ISBN:0721601464, MESH:D055014, PMCID:PMC2213186, PMCID:PMC548021, PMID:16551251, PMID:16647566]
comment: Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "CFU-C , Colony forming unit in culture" BROAD [http://www.copewithcytokines.de]
synonym: "CFU-GM" RELATED OMO:0003000 [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
synonym: "colony forming unit granulocyte macrophage" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
synonym: "GMP" RELATED OMO:0003000 [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
synonym: "granulocyte-macrophage progenitor" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
synonym: "granulocyte/monocyte precursor" EXACT []
synonym: "granulocyte/monocyte progenitor" EXACT []
xref: ZFA:0009251 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000763 ! myeloid cell
is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
is_a: CL:1001610 ! bone marrow hematopoietic cell
intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: capable_of GO:0030225 ! macrophage differentiation
intersection_of: capable_of GO:0030851 ! granulocyte differentiation
intersection_of: CL:4030045 PR:000007857 ! lacks_part erythroid transcription factor
intersection_of: CL:4030045 PR:000007858 ! lacks_part endothelial transcription factor GATA-2
intersection_of: has_part PR:000001944 ! transcription factor PU.1
intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha
intersection_of: part_of UBERON:0002371 ! bone marrow
intersection_of: RO:0002104 PR:000001865 ! has plasma membrane part interleukin-3 receptor class 2 alpha chain
relationship: capable_of GO:0030225 ! macrophage differentiation
relationship: capable_of GO:0030851 ! granulocyte differentiation
relationship: CL:4030045 PR:000007857 ! lacks_part erythroid transcription factor
relationship: CL:4030045 PR:000007858 ! lacks_part endothelial transcription factor GATA-2
relationship: has_part PR:000001944 ! transcription factor PU.1
relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha
relationship: part_of UBERON:0002371 ! bone marrow
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 PR:000001865 ! has plasma membrane part interleukin-3 receptor class 2 alpha chain
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000557" xsd:string {name="granulocyte monocyte progenitor cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000558
name: reticulocyte
def: "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds." [GOC:add, GOC:tfm, PMID:15946868, PMID:2037622]
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
xref: BTO:0001173
xref: CALOHA:TS-0864
xref: MESH:D012156
xref: ZFA:0009252 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell
intersection_of: CL:0000764 ! erythroid lineage cell
intersection_of: capable_of GO:0071971 ! extracellular exosome assembly
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
intersection_of: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1
relationship: capable_of GO:0071971 ! extracellular exosome assembly
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
relationship: develops_from CL:0000552 ! orthochromatic erythroblast
relationship: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1
[Term]
id: CL:0000559
name: promonocyte
def: "A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules." [GOC:tfm, ISBN:0721601464]
comment: Morphology: Mononuclear cell, diameter 14-18 _M, fine azurophilic granules; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; Fetal: Liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid.
subset: cellxgene_subset
subset: human_reference_atlas
xref: BTO:0004657
xref: FMA:83551
xref: ZFA:0009253 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002194 {is_inferred="true"} ! monopoietic cell
intersection_of: CL:0002194 ! monopoietic cell
intersection_of: capable_of GO:0030224 ! monocyte differentiation
intersection_of: has_part GO:0042582 ! azurophil granule
intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
relationship: capable_of GO:0030224 ! monocyte differentiation
relationship: develops_from CL:0000040 ! monoblast
relationship: has_part GO:0042582 ! azurophil granule
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000559" xsd:string {name="promonocyte on CELLxGENE CellGuide"}
[Term]
id: CL:0000561
name: amacrine cell
def: "Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. They lack large axons." [GOC:tfm, MESH:D025042, WikipediaVersioned:Amacrine_cell&oldid=1023572246]
subset: cellxgene_subset
subset: eye_upper_slim
subset: human_reference_atlas
synonym: "AC" RELATED OMO:0003000 [doi:10.1038/s41598-020-66092-9]
synonym: "ACs" RELATED OMO:0003004 [doi:10.1038/s41598-020-66092-9]
synonym: "amacrine neuron" EXACT []
xref: BTO:0004044
xref: FMA:67766
xref: ZFA:0009255 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000099 ! interneuron
is_a: CL:0009004 ! retinal cell
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: part_of RO:0002577 ! system
relationship: part_of UBERON:0000966 ! retina
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002120 CL:0000740 ! synapsed to retinal ganglion cell
[Term]
id: CL:0000562
name: nucleate erythrocyte
def: "An erythrocyte having a nucleus." [GOC:add, GOc:tfm]
synonym: "RBC" BROAD []
synonym: "red blood cell" BROAD []
xref: ZFA:0009256 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000232 {is_inferred="true"} ! erythrocyte
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000232 ! erythrocyte
intersection_of: RO:0000053 PATO:0002505 ! has characteristic nucleated
relationship: develops_from CL:0002421 ! nucleated reticulocyte
relationship: RO:0000053 PATO:0002505 ! has characteristic nucleated
[Term]
id: CL:0000566
name: angioblastic mesenchymal cell
def: "A mesenchymal stem cell capable of developing into blood vessel endothelium." [GOC:dsd, GOC:tfm, PMID:12768659]
comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive.
synonym: "angioblast" EXACT []
synonym: "chondroplast" EXACT []
xref: ZFA:0009258 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: RO:0002104 PR:000001444 ! has plasma membrane part cadherin-5
intersection_of: RO:0002104 PR:000002112 ! has plasma membrane part vascular endothelial growth factor receptor 2
intersection_of: RO:0002104 PR:000016043 ! has plasma membrane part T-cell acute lymphocytic leukemia protein 1
relationship: develops_from CL:0000134 ! mesenchymal stem cell
relationship: RO:0002104 PR:000001444 ! has plasma membrane part cadherin-5
relationship: RO:0002104 PR:000002112 ! has plasma membrane part vascular endothelial growth factor receptor 2
relationship: RO:0002104 PR:000016043 ! has plasma membrane part T-cell acute lymphocytic leukemia protein 1
[Term]
id: CL:0000568
name: amine precursor uptake and decarboxylation cell
def: "A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell." [GOC:tfm, ISBN:0721662544]
synonym: "APUD cell" EXACT []
xref: BTO:0003866
xref: FMA:83114
xref: MESH:D001078
is_a: CL:0000165 ! neuroendocrine cell
[Term]
id: CL:0000569
name: cardiac mesenchymal cell
def: "A mesenchymal cell found in the developing heart and that develops into some part of the heart. These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field." [PMID:18816864]
subset: cellxgene_subset
xref: ZFA:0009259 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0008019 ! mesenchymal cell
is_a: CL:2000073 ! migratory cardiac neural crest cell
intersection_of: CL:0008019 ! mesenchymal cell
intersection_of: develops_into CL:0002494 ! cardiocyte
relationship: develops_into CL:0002494 ! cardiocyte
[Term]
id: CL:0000570
name: parafollicular cell
def: "A neuroepithelial cells that occurs singly or in small groups, close to the outer follicular borders but within the follicular basement membrane of the thyroid. This cell expresses a form of the neural cell adhesion molecule (N-CAM) on its surface and secretes calcitonin and serotonin (5-hydroxytryptamine)." [GOC:tfm, ISBN:0517223651]
synonym: "C cell" EXACT []
synonym: "C cell of thyroid gland" EXACT [FMA:68653]
synonym: "clear cell of thyroid gland" EXACT [FMA:68653]
synonym: "parafollicular cell of thyroid gland" EXACT [FMA:68653]
synonym: "thyroid parafollicular cell" EXACT [FMA:68653]
xref: FMA:68653
xref: SCTID:176770005
xref: ZFA:0009260 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000163 ! endocrine cell
is_a: CL:0000443 ! calcitonin secreting cell
is_a: CL:0000458 ! serotonin secreting cell
is_a: CL:0000710 {is_inferred="true"} ! neurecto-epithelial cell
is_a: CL:0002257 ! epithelial cell of thyroid gland
relationship: develops_from CL:0000333 ! migratory neural crest cell
relationship: part_of UBERON:0001747 ! parenchyma of thyroid gland
relationship: RO:0002104 PR:000001024 ! has plasma membrane part neural cell adhesion molecule 1
[Term]
id: CL:0000573
name: retinal cone cell
def: "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision." [MESH:D017949]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "cone" RELATED [doi:10.1038/s41598-020-66092-9]
xref: BTO:0001036
xref: CALOHA:TS-0866
xref: FMA:67748
xref: ZFA:0009262 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0010009 ! camera-type eye photoreceptor cell
relationship: develops_from CL:0002672 ! retinal progenitor cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000573" xsd:string {name="retinal cone cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000574
name: erythrophore
def: "A pigment cell derived from the neural crest. Contains pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives an orange to red appearance." [SANBI:mhl]
xref: ZFA:0009263 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000147 ! pigment cell
is_a: CL:0000255 ! eukaryotic cell
relationship: develops_from CL:0005004 ! pigment erythroblast
[Term]
id: CL:0000575
name: corneal epithelial cell
def: "An epithelial cell of the cornea." [GOC:tfm]
subset: cellxgene_subset
subset: eye_upper_slim
subset: human_reference_atlas
synonym: "epithelial cell of cornea" EXACT [FMA:70551]
xref: BTO:0004298
xref: CALOHA:TS-0173
xref: FMA:70551
xref: ZFA:0009264 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0002159 ! general ecto-epithelial cell
intersection_of: CL:0000076 ! squamous epithelial cell
intersection_of: part_of UBERON:0001772 ! corneal epithelium
relationship: part_of UBERON:0001772 ! corneal epithelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000575" xsd:string {name="corneal epithelial cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000576
name: monocyte
def: "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." [GO_REF:0000031, MESH:D009000]
comment: Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid.
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_reference_atlas
xref: BTO:0000876
xref: CALOHA:TS-0638
xref: FMA:62864
xref: ZFA:0009265 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000113 ! mononuclear phagocyte
is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0000766 ! myeloid leukocyte
intersection_of: capable_of GO:0030225 ! macrophage differentiation
intersection_of: capable_of GO:0030316 ! osteoclast differentiation
intersection_of: capable_of GO:0043011 ! myeloid dendritic cell differentiation
intersection_of: RO:0000053 PATO:0001407 ! has characteristic mononucleate
relationship: capable_of GO:0030225 ! macrophage differentiation
relationship: capable_of GO:0030316 ! osteoclast differentiation
relationship: capable_of GO:0043011 ! myeloid dendritic cell differentiation
relationship: develops_from CL:0000559 ! promonocyte
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0000053 PATO:0001407 ! has characteristic mononucleate
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000576" xsd:string {name="monocyte on CELLxGENE CellGuide"}
[Term]
id: CL:0000586
name: germ cell
def: "The reproductive cell in multicellular organisms." [MESH:D005854]
subset: cellxgene_subset
xref: BTO:0000535
xref: NCIT:C12597
xref: VHOG:0001534
xref: WBbt:0006796
is_a: CL:0000039 {is_inferred="true"} ! germ line cell
relationship: capable_of_part_of GO:0009566 ! fertilization
[Term]
id: CL:0000588
name: odontoclast
def: "A specialized osteoclast associated with the absorption and removal of cementum." [GOC:add]
xref: BTO:0002516
xref: FMA:83027
xref: ZFA:0009270 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000092 {is_inferred="true"} ! osteoclast
intersection_of: CL:0000092 ! osteoclast
intersection_of: capable_of GO:0042483 ! negative regulation of odontogenesis
relationship: capable_of GO:0042483 ! negative regulation of odontogenesis
[Term]
id: CL:0000593
name: androgen secreting cell
def: "A steroid hormone secreting cell that secretes androgen." [GOC:tfm]
xref: ZFA:0009271 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000174 ! steroid hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0035935 ! androgen secretion
relationship: capable_of GO:0035935 ! androgen secretion
[Term]
id: CL:0000595
name: enucleate erythrocyte
def: "An erythrocyte lacking a nucleus." [GOC:add, GOC:tfm]
subset: cellxgene_subset
synonym: "RBC" RELATED OMO:0003000 []
synonym: "red blood cell" BROAD []
is_a: CL:0000225 ! anucleate cell
is_a: CL:0000232 {is_inferred="true"} ! erythrocyte
intersection_of: CL:0000232 ! erythrocyte
intersection_of: RO:0000053 PATO:0001405 ! has characteristic anucleate
relationship: develops_from CL:0002422 ! enucleated reticulocyte
relationship: RO:0000053 PATO:0001405 ! has characteristic anucleate
[Term]
id: CL:0000598
name: pyramidal neuron
def: "Pyramidal neurons have a pyramid-shaped soma with a single axon, a large apical dendrite and multiple basal dendrites. The apex and an apical dendrite typically point toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their region. Pyramidal neurons are found in the cerebral cortex, the hippocampus, and the amygdala." [GOC:tfm, MESH:D017966]
subset: BDS_subset
subset: cellxgene_subset
synonym: "projection neuron" EXACT []
synonym: "pyramidal cell" EXACT []
xref: BTO:0003102
xref: FMA:67310
xref: FMA:86775
xref: NIFSTD:sao862606388
xref: ZFA:0009273 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0000053 PATO:0070015 ! has characteristic pyramidal family morphology
relationship: RO:0000053 PATO:0070015 ! has characteristic pyramidal family morphology
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000598" xsd:string {name="pyramidal neuron on CELLxGENE CellGuide"}
[Term]
id: CL:0000604
name: retinal rod cell
def: "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision." [MESH:D017948]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "rod" RELATED [doi:10.1038/s41598-020-66092-9]
xref: BTO:0001024
xref: CALOHA:TS-0870
xref: FMA:67747
xref: ZFA:0009275 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0010009 ! camera-type eye photoreceptor cell
relationship: develops_from CL:0002672 ! retinal progenitor cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000604" xsd:string {name="retinal rod cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000609
name: vestibular hair cell
def: "A mechanoreceptor located in the acoustic maculae and the semicircular canals that mediates the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the vestibulocochlear nerve to the brain stem." [GOC:tfm, MESH:D018069]
synonym: "vestibular receptor cell" EXACT []
xref: FMA:62351
is_a: CL:0002374 ! ear hair cell
[Term]
id: CL:0000617
name: GABAergic neuron
def: "A neuron that uses GABA as a vesicular neurotransmitter" [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "GABA-ergic neuron" EXACT []
xref: FBbt:00007228 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
xref: FMA:84788
xref: MESH:D059330
xref: WBbt:0005190
xref: ZFA:0009276 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000151 ! secretory cell
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission
relationship: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000622
name: acinar cell
def: "A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus)." [GOC:tfm, http://www.copewithcytokines.de]
subset: cellxgene_subset
synonym: "acinic cell" EXACT []
synonym: "acinous cell" EXACT []
xref: FMA:83625
xref: MESH:D061354
xref: ZFA:0009277 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000150 ! glandular secretory epithelial cell
is_a: CL:0000154 ! protein secreting cell
intersection_of: CL:0000150 ! glandular secretory epithelial cell
intersection_of: CL:0000154 ! protein secreting cell
intersection_of: part_of UBERON:0009842 ! glandular acinus
relationship: part_of UBERON:0009842 ! glandular acinus
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000622" xsd:string {name="acinar cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000623
name: natural killer cell
def: "A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells." [GOC:add, ISBN:0781735149, PMID:15771571]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "large granular lymphocyte" BROAD []
synonym: "NK cell" EXACT []
synonym: "null cell" BROAD []
xref: BTO:0000914
xref: BTO:0004716
xref: CALOHA:TS-0664
xref: FMA:63147
xref: FMA:83601
xref: MESH:D007694
xref: VHOG:0001697
xref: ZFA:0009278 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0001067 ! group 1 innate lymphoid cell
intersection_of: CL:0001067 ! group 1 innate lymphoid cell
intersection_of: capable_of GO:0002228 ! natural killer cell mediated immunity
intersection_of: capable_of GO:0050776 ! regulation of immune response
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
relationship: capable_of GO:0002228 ! natural killer cell mediated immunity
relationship: capable_of GO:0050776 ! regulation of immune response
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
relationship: develops_from CL:0000825 ! pro-NK cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000626
name: olfactory granule cell
def: "A granule cell that has a soma located in an olfactory bulb granule cell layer. An olfactory granule cell is an interneuron that lacks an axon, makes reciprocal dendro-dendritic synapses with mitral cells and tufted cells and is involved in the fine spatio-temporal tuning of the responses of these principal olfactory bulb neurons to odors." [doi:10.1038/s41598-018-27692-8, GOC:mah]
comment: Granule cells are the most abundant neuronal population in the olfactory bulb and are continuously renewed throughout life. {xref="doi:10.1038/s41598-018-27692-8"}
synonym: "olfactory bulb granule cell" EXACT [doi:10.1038/s41598-018-27692-8]
xref: ZFA:0001694 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000120 ! granule cell
is_a: CL:1001434 ! olfactory bulb interneuron
intersection_of: CL:0000120 ! granule cell
intersection_of: RO:0002100 UBERON:0005378 ! has soma location olfactory bulb granule cell layer
relationship: part_of RO:0002577 ! system
relationship: RO:0002100 UBERON:0005378 ! has soma location olfactory bulb granule cell layer
relationship: RO:0002120 CL:1001502 ! synapsed to mitral cell
relationship: RO:0002120 CL:1001503 ! synapsed to olfactory bulb tufted cell
relationship: RO:0002428 GO:0007608 ! involved in regulation of sensory perception of smell
relationship: synapsed_by CL:1001502 ! mitral cell
relationship: synapsed_by CL:1001503 ! olfactory bulb tufted cell
[Term]
id: CL:0000630
name: supporting cell
def: "A cell whose primary function is to support other cell types." [FB:ma, GOC:tfm]
subset: cellxgene_subset
synonym: "supportive cell" EXACT []
xref: BTO:0002315
xref: ZFA:0009387 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000000 ! cell
[Term]
id: CL:0000632
name: hepatic stellate cell
def: "A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver." [GOC:dsd, http://en.wikipedia.org/wiki/Hepatic_stellate_cell, MESH:D055166, PMID:12808230, PMID:17239632, PMID:18222966, PMID:9302568]
comment: Hepatic stellate cells are CD271-positive, desmin-positive, DDR-2-positive, GFAP-positive, synamin-positive, synaptophysin-positive, vimentin-positive, They are capable of producing angiotensin II, fibronectin, laminin, MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TGF-beta1, TIMP-1, TIMP-2, type I collagen, type III collagen, type IV collagen, and type VI collagen.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "fat-storing cell" RELATED []
synonym: "hepatic perisinusoidal cell" EXACT []
synonym: "Ito cell" EXACT []
synonym: "lipocyte" RELATED []
synonym: "perisinusoidal cell" EXACT []
synonym: "vitamin A-storing cells" RELATED [PMID:12808230]
xref: BTO:0002741
xref: CALOHA:TS-0452
xref: FMA:67763
xref: ZFA:0009279 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000057 ! fibroblast
is_a: CL:0000327 ! extracellular matrix secreting cell
intersection_of: CL:0002320 ! connective tissue cell
intersection_of: part_of UBERON:0002107 ! liver
intersection_of: RO:0002104 PR:000007939 ! has plasma membrane part glial fibrillary acidic protein
relationship: part_of UBERON:0002107 ! liver
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 PR:000007939 ! has plasma membrane part glial fibrillary acidic protein
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000632" xsd:string {name="hepatic stellate cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000636
name: Mueller cell
def: "Astrocyte-like radial glial cell that extends vertically throughout the retina, with the nucleus are usually in the middle of the inner nuclear layer." [GOC:NV, PMID:21911394]
subset: cellxgene_subset
subset: eye_upper_slim
subset: human_reference_atlas
synonym: "Muller cell" EXACT MISSPELLING [doi:10.21769/BioProtoc.4179]
synonym: "Muller glia" EXACT []
synonym: "Müller cell" EXACT []
xref: BTO:0003064
xref: ZFA:0009280 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000681 ! radial glial cell
is_a: CL:0009004 ! retinal cell
relationship: part_of UBERON:0000966 ! retina
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000636" xsd:string {name="Mueller cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000637
name: chromophil cell of anterior pituitary gland
def: "A cell that stains readily in the anterior pituitary gland." [GOC:tfm, ISBN:0618947256]
xref: FMA:83089
is_a: CL:0000150 ! glandular secretory epithelial cell
is_a: CL:0000166 ! chromaffin cell
is_a: CL:0000167 ! peptide hormone secreting cell
is_a: CL:0012001 ! neuron of the forebrain
is_a: CL:2000004 ! pituitary gland cell
intersection_of: CL:0000166 ! chromaffin cell
intersection_of: part_of UBERON:0002196 ! adenohypophysis
relationship: part_of UBERON:0002196 ! adenohypophysis
[Term]
id: CL:0000638
name: acidophil cell of pars distalis of adenohypophysis
def: "An acidophilic chromophil cell that of the anterior pituitary gland." [GOC:tfm]
synonym: "acidophil cell of pars anterior of adenohypophysis" EXACT []
synonym: "acidophil of pars anterior of adenohypophysis" EXACT []
synonym: "acidophil of pars distalis of adenohypophysis" EXACT []
synonym: "pituitary alpha cell" EXACT []
xref: FMA:83093
is_a: CL:0000637 ! chromophil cell of anterior pituitary gland
relationship: part_of UBERON:0006964 ! pars distalis of adenohypophysis
[Term]
id: CL:0000642
name: folliculostellate cell
def: "An agranular supporting cell of the anterior pituitary (adenohypophysis) that is characterized by a star-like morphology and ability to form follicles. Folliculostellate cells communicate with each other and with endocrine cells via gap junctions." [doi:10.23937/2572-407X.1510006, JB:jb, PMID:10495875, PMID:15961560]
comment: Folliculostellate cells are a heterogeneous group of cells rather than a single cell type, with different morphology and gene expression profiles. Due to this heterogeneity, it is unclear if different properties that have been attributed to folliculostellate cells (pluripotent, proliferative, phagocytic) are common in all folliculostellate cells or limited to particular subsets. {xref="doi:10.23937/2572-407X.1510006", xref="PMID:34734454", xref="PMID:31620083", xref="PMID:18287078"}
synonym: "folliculo-stellate cell" EXACT [doi:10.23937/2572-407X.1510006]
synonym: "FS cell" RELATED OMO:0003000 [PMID:34734454]
synonym: "FSC" RELATED OMO:0003000 [doi:10.23937/2572-407X.1510006]
synonym: "pituitary folliculostellate cell" EXACT [PMID:34734454]
synonym: "Sox2-positive stem cell" RELATED [PMID:34734454]
xref: ZFA:0009281 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000630 ! supporting cell
is_a: CL:2000004 ! pituitary gland cell
relationship: part_of UBERON:0002196 ! adenohypophysis
[Term]
id: CL:0000646
name: basal cell
def: "Undifferentiated; mitotic stem cell for other epithelial cell types; rounded or elliptical with little cytoplasm and few organelles; contain cytokeratin intermediate filament." [GOC:tfm, ISBN:0517223651]
subset: cellxgene_subset
subset: human_reference_atlas
xref: BTO:0000939
xref: FMA:62516
is_a: CL:0000036 ! epithelial fate stem cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000648
name: kidney granular cell
def: "A smooth muscle cell that synthesizes, stores, and secretes the enzyme renin. This cell type are located in the wall of the afferent arteriole at the entrance to the glomerulus. While having a different origin than other kidney smooth muscle cells, this cell type expresses smooth muscle actin upon maturation." [GOC:cvs, GOC:tfm, PMID:11457727]
subset: human_reference_atlas
synonym: "JG cell" EXACT []
synonym: "juxtaglomerular cell" BROAD []
synonym: "renin secreting cell" EXACT []
xref: FMA:84138
xref: ZFA:0005238 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000154 ! protein secreting cell
is_a: CL:0000192 ! smooth muscle cell
is_a: CL:1000618 ! juxtaglomerular complex cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0002001 ! renin secretion into blood stream
intersection_of: part_of UBERON:0002113 ! kidney
relationship: capable_of GO:0002001 ! renin secretion into blood stream
relationship: part_of UBERON:0002113 ! kidney
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000649
name: spinous cell of epidermis
def: "A keratinocyte found within the stratum spinosum (prickle cell layer) of the epidermis, distinguished by numerous intercellular desmosomes, which give it a “prickly” or spiny appearance. Positioned above the mitotically active basal layer and beneath the granular layer, it contributes to the skin’s mechanical strength and barrier function, preventing water loss and pathogen entry. This cell expresses differentiation-specific keratins K1 and K10 in mice, unlike basal cells that express K5 and K14, and lacks the keratohyalin granules found in granular cells, marking its intermediate stage of epidermal differentiation." [GOC:tfm, ISBN:0721662544, ISBN:0815332181, PMID:21860392, PMID:32097634, WIKIPEDIA:Spinous_cell]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "prickle cell of epidermis" EXACT [WIKIPEDIA:Spinous_cell]
synonym: "spinous keratinocytes of epidermis" EXACT [PMID:32843640]
xref: FMA:69059
is_a: CL:4052060 ! spinous cell
is_a: CL:4052061 ! epidermal keratinocyte
intersection_of: CL:4052060 ! spinous cell
intersection_of: part_of UBERON:0002026 ! stratum spinosum of epidermis
relationship: part_of UBERON:0002026 ! stratum spinosum of epidermis
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000650
name: mesangial cell
def: "A cell type that encapsulates the capillaries and venules in the kidney. This cell secretes mesangial matrix that provides the structural support for the capillaries." [GOC:tfm, http://www.copewithcytokines.de/cope.cgi?key=mesangial%20cells]
comment: Do all of these cells really develop from some mesenchymal stem cell?
subset: cellxgene_subset
synonym: "kidney mesangial cell" EXACT []
xref: BTO:0000853
xref: CALOHA:TS-0617
xref: FMA:70972
xref: MESH:D050527
xref: ZFA:0009283 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0002681 ! kidney cortical cell
is_a: CL:1001318 ! renal interstitial pericyte
relationship: develops_from CL:0000134 ! mesenchymal stem cell
relationship: part_of UBERON:0002319 ! mesangium
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000650" xsd:string {name="mesangial cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000652
name: pinealocyte
def: "This cell type produces and secretes melatonin and forms the pineal parenchyma. Extending from each cell body, which has a spherical, oval or lobulated mucleus, are one or more tortuous basophilic processes, containing parallel microtubules known as synaptic ribbons. These processes end in expanded terminal buds near capillaries or less, frequently, ependymal cells of the pineal recess. The terminal buds contain granular endoplasmic reticulum, mitochondria and electron-dense cored vesicles, which store monoamines and polypeptide hormones, release of which appears to require sympathetic innervation." [GOC:tfm, http://en.wikipedia.org/wiki/Pinealocyte, ISBN:0517223651, PMID:16687276]
subset: cellxgene_subset
xref: BTO:0001068
xref: FMA:83417
xref: ZFA:0009284 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000150 ! glandular secretory epithelial cell
is_a: CL:0000163 ! endocrine cell
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:0002319 ! neural cell
relationship: capable_of GO:0030187 ! melatonin biosynthetic process
relationship: part_of UBERON:0001905 ! pineal body
[Term]
id: CL:0000653
name: podocyte
def: "A specialized kidney epithelial cell, contained within a glomerulus, that contains \"feet\" that interdigitate with the \"feet\" of other podocytes." [GOC:tfm, https://doi.org/10.1101/2021.10.10.463829]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "epithelial cell of visceral layer of glomerular capsule" BROAD [FMA:70967]
synonym: "glomerular podocyte" EXACT [FMA:70967]
synonym: "glomerular visceral epithelial cell" EXACT []
synonym: "kidney podocyte" EXACT []
synonym: "renal podocyte" EXACT []
xref: BTO:0002295
xref: FMA:70967
xref: ZFA:0009285 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0002522 ! renal filtration cell
is_a: CL:1000450 ! epithelial cell of glomerular capsule
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0005751 ! glomerular visceral epithelium
relationship: part_of UBERON:0005751 ! glomerular visceral epithelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000653" xsd:string {name="podocyte on CELLxGENE CellGuide"}
property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/1460" xsd:string
[Term]
id: CL:0000654
name: primary oocyte
def: "A primary oocyte is an oocyte that has not completed female meosis I." [GOC:tfm, ISBN:0721662544]
subset: human_reference_atlas
synonym: "primary oogonium" RELATED []
xref: BTO:0000512
xref: FMA:18645
is_a: CL:0000023 {is_inferred="true"} ! oocyte
intersection_of: CL:0000023 ! oocyte
intersection_of: CL:4030044 GO:0051321 ! has_not_completed meiotic cell cycle
relationship: CL:4030044 GO:0051321 ! has_not_completed meiotic cell cycle
relationship: develops_from CL:0000024 ! oogonial cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000655
name: secondary oocyte
def: "A secondary oocyte is an oocyte that has not completed meiosis II." [GOC:tfm, ISBN:0721662544]
synonym: "primary oogonium" RELATED []
xref: BTO:0003094
xref: FMA:18646
is_a: CL:0000023 {is_inferred="true"} ! oocyte
intersection_of: CL:0000023 ! oocyte
intersection_of: CL:4030044 GO:0007147 ! has_not_completed female meiosis II
relationship: CL:4030044 GO:0007147 ! has_not_completed female meiosis II
relationship: develops_from CL:0000654 ! primary oocyte
[Term]
id: CL:0000656
name: primary spermatocyte
def: "A diploid cell that has derived from a spermatogonium and can subsequently begin meiosis and divide into two haploid secondary spermatocytes." [GOC:tfm, ISBN:0721662544]
xref: BTO:0001115
xref: CALOHA:TS-2194
xref: FMA:72292
is_a: CL:0000017 ! spermatocyte
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000017 ! spermatocyte
intersection_of: capable_of GO:0007140 ! male meiotic nuclear division
intersection_of: RO:0000053 PATO:0001394 ! has characteristic diploid
relationship: capable_of GO:0007140 ! male meiotic nuclear division
relationship: RO:0000053 PATO:0001394 ! has characteristic diploid
[Term]
id: CL:0000657
name: secondary spermatocyte
def: "One of the two haploid cells into which a primary spermatocyte divides, and which in turn gives origin to spermatids." [GOC:tfm, ISBN:0721662544]
xref: BTO:0000709
xref: CALOHA:TS-2195
xref: FBbt:00004941 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
xref: FMA:72293
is_a: CL:0000017 ! spermatocyte
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000413 ! haploid cell
intersection_of: CL:0000017 ! spermatocyte
intersection_of: capable_of GO:0007142 ! male meiosis II
intersection_of: RO:0000053 PATO:0001375 ! has characteristic haploid
relationship: capable_of GO:0007142 ! male meiosis II
relationship: develops_from CL:0000656 ! primary spermatocyte
relationship: RO:0000053 PATO:0001375 ! has characteristic haploid
[Term]
id: CL:0000666
name: fenestrated endothelial cell
def: "An endothelial cell that has small pores, or fenestrations, which allow for the efficient exchange of substances between the blood and surrounding tissues." [DOI:10.1007/978-3-211-99390-3_133]
subset: cellxgene_subset
synonym: "window cell" EXACT []
xref: ZFA:0009286 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000115 ! endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: RO:0000053 PATO:0002064 ! has characteristic fenestrated
relationship: RO:0000053 PATO:0002064 ! has characteristic fenestrated
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000666" xsd:string {name="fenestrated endothelial cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000667
name: collagen secreting cell
def: "An extracellular matrix secreting cell that secretes collagen." [GOC:tfm]
subset: cellxgene_subset
xref: ZFA:0009287 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000327 ! extracellular matrix secreting cell
[Term]
id: CL:0000669
name: pericyte
def: "An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells." [GOC:dsd, GOC:tfm, ISBN:0721662544, MESH:D020286, PMID:16807374, PMID:17986482, PMID:20024907]
comment: Pericytes are CD10-positive, CD13-positive, CD31-negative, CD45-negative, CD106-positive, CD117-negative, CD140-positive, CD144-negative, CD146-positive, CD271-positive, CD325-positive, NG2-positive, RGS5-positive, SMA-positive, and desmin-positive. A subpopulation is CD248-positive. They are also capable of producing angiopoietin 1, CXCL12, TGF-beta, and VEGF-A.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "adventitial cell" RELATED []
synonym: "adventitial reticular cell" EXACT []
synonym: "ARC" EXACT [PMID:17986482]
synonym: "cell of Rouget" EXACT []
synonym: "pericyte cell" EXACT []
synonym: "pericyte of Rouget" EXACT []
xref: BTO:0002441
xref: FMA:63174
xref: ZFA:0009112 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000183 ! contractile cell
is_a: CL:0000630 ! supporting cell
is_a: CL:0002320 ! connective tissue cell
is_a: CL:0008034 ! mural cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000669" xsd:string {name="pericyte on CELLxGENE CellGuide"}
[Term]
id: CL:0000670
name: primordial germ cell
def: "A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells." [GOC:tfm, PMID:1381289]
subset: cellxgene_subset
synonym: "gonocyte" EXACT []
synonym: "primitive germ cell" EXACT []
xref: FMA:70567
xref: ZFA:0009288 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000039 {is_inferred="true"} ! germ line cell
is_a: CL:0000219 {is_inferred="true"} ! motile cell
intersection_of: CL:0000039 ! germ line cell
intersection_of: capable_of GO:0048870 ! cell motility
intersection_of: part_of UBERON:0000922 ! embryo
relationship: capable_of GO:0048870 ! cell motility
relationship: part_of UBERON:0000922 ! embryo
[Term]
id: CL:0000675
name: female gamete
def: "A mature sexual reproductive cell of the female germline." [GOC:tfm]
is_a: CL:0000021 {is_inferred="true"} ! female germ cell
is_a: CL:0000300 ! gamete
[Term]
id: CL:0000679
name: glutamatergic neuron
def: "A neuron that is capable of some neurotansmission by glutamate secretion." []
subset: cellxgene_subset
subset: human_reference_atlas
xref: FBbt:00100291 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
xref: WBbt:0006829
xref: ZFA:0009290 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000151 ! secretory cell
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0061535 ! glutamate secretion, neurotransmission
relationship: capable_of GO:0061535 ! glutamate secretion, neurotransmission
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000680
name: muscle precursor cell
def: "A non-terminally differentiated cell that is capable of developing into a muscle cell." [GOC:add]
subset: cellxgene_subset
xref: ZFA:0009291 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0011115 ! precursor cell
intersection_of: develops_into CL:0000187 ! muscle cell
relationship: develops_from CL:0000222 ! mesodermal cell
relationship: develops_into CL:0000187 ! muscle cell
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000680" xsd:string {name="muscle precursor cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000681
name: radial glial cell
def: "A cell present in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration." [GOC:dph]
comment: Unlike that of mammals, the brain of adult teleost fish exhibits an intense and widespread neurogenic activity as a result of the persistence of\nradial glial cells acting as neural progenitors throughout life.
subset: cellxgene_subset
synonym: "forebrain radial glial cell" NARROW []
xref: ZFA:0009292 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000125 ! glial cell
relationship: develops_from CL:0000710 ! neurecto-epithelial cell
[Term]
id: CL:0000686
name: cerebrospinal fluid secreting cell
def: "A columnar/cuboidal epithelial cell that secretes cerebrospinal fluid." [GOC:tfm]
xref: ZFA:0009295 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:1100001 ! secretory epithelial cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0033326 ! cerebrospinal fluid secretion
relationship: capable_of GO:0033326 ! cerebrospinal fluid secretion
relationship: develops_from CL:0000333 ! migratory neural crest cell
[Term]
id: CL:0000691
name: stellate interneuron
def: "Any interneuron that has characteristic some stellate morphology." [FBC:Autogenerated]
subset: BDS_subset
xref: ZFA:0009297 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000099 ! interneuron
is_a: CL:0000122 ! stellate neuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0000053 PATO:0070010 ! has characteristic stellate morphology
relationship: RO:0000053 PATO:0070010 ! has characteristic stellate morphology
[Term]
id: CL:0000696
name: PP cell
def: "A cell that stores and secretes pancreatic polypeptide hormone." [GOC:tfm, JB:jb, PMID:15153415]
subset: cellxgene_subset
synonym: "type F enteroendocrine cell" EXACT []
xref: FMA:62938
xref: FMA:83409
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000167 ! peptide hormone secreting cell
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000696" xsd:string {name="PP cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000700
name: dopaminergic neuron
def: "A neuron that releases dopamine as a neurotransmitter." [GOC:dhill]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "dopaminergic cell" EXACT []
xref: BTO:0004032
xref: FBbt:00005131 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
xref: FMA:84787
xref: MESH:D059290
xref: WBbt:0006746
xref: ZFA:0009301 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:4033050 ! catecholaminergic neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0061527 ! dopamine secretion, neurotransmission
relationship: capable_of GO:0061527 ! dopamine secretion, neurotransmission
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000703
name: sustentacular cell
def: "Cell that provides some or all mechanical, nutritional and phagocytic support to their neighbors." [JB:jb]
xref: BTO:0002315
xref: ZFA:0009302 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000630 ! supporting cell
[Term]
id: CL:0000706
name: choroid plexus epithelial cell
def: "A specialized ependymal cell that is part of the choroid plexus epithelium, responsible for producing cerebrospinal fluid (CSF) by selectively filtering and modifying blood plasma components before secreting it into the brain and spinal cord. This cell is characterized by a brush border on its apical surface, which enhances the secretion of CSF." [GOC:add, GOC:tfm, JB:jb, PMID:15561411, PMID:9550134]
comment: A choroid plexus epithelial cell possesses non-motile 9+0 cilia. While these cilia can exhibit transient motility during development, they generally do not contribute significantly to the directional flow of cerebrospinal fluid (CSF). Instead, they are primarily involved in sensory functions. {xref="PMID:25729351"}
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "choroid plexus cell" BROAD [DOI:10.1101/2022.10.12.511898]
synonym: "epithelial cell of choroid plexus" EXACT []
xref: FMA:70549
xref: ZFA:0009304 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000065 ! ependymal cell
is_a: CL:0000239 ! brush border epithelial cell
intersection_of: CL:0000065 ! ependymal cell
intersection_of: part_of UBERON:0003911 ! choroid plexus epithelium
relationship: capable_of GO:0033326 ! cerebrospinal fluid secretion
relationship: part_of UBERON:0003911 ! choroid plexus epithelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2023-08-04T08:48:30Z" xsd:dateTime
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000706" xsd:string {name="choroid plexus epithelial cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000708
name: leptomeningeal cell
def: "Stromal cell that forms the internal covering of the vertebrate brain and produces ECM for this and the choroid plexus." [JB:jb]
subset: cellxgene_subset
synonym: "leptomemingeal cell" RELATED []
xref: ZFA:0009305 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000327 {is_inferred="true"} ! extracellular matrix secreting cell
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000327 ! extracellular matrix secreting cell
intersection_of: part_of UBERON:0003210 ! blood-cerebrospinal fluid barrier
relationship: part_of UBERON:0003210 ! blood-cerebrospinal fluid barrier
[Term]
id: CL:0000710
name: neurecto-epithelial cell
def: "Epithelial cells derived from neural plate and neural crest." [GOC:tfm]
comment: The term "neuroepithelial cell" is used to describe both this cell type and sensory epithelial cell (CL:0000098).
synonym: "neuroepithelial cell" BROAD []
xref: BTO:0004301
xref: FMA:70557
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
is_a: CL:0002077 ! ecto-epithelial cell
intersection_of: CL:0002077 ! ecto-epithelial cell
intersection_of: develops_from CL:0000133 ! neurectodermal cell
relationship: develops_from CL:0000133 ! neurectodermal cell
[Term]
id: CL:0000712
name: stratum granulosum cell
def: "Any epidermal cell that is part of some stratum granulosum of epidermis." [FBC:Autogenerated]
is_a: CL:0000362 ! epidermal cell
intersection_of: CL:0000362 ! epidermal cell
intersection_of: part_of UBERON:0002069 ! stratum granulosum of epidermis
relationship: part_of UBERON:0002069 ! stratum granulosum of epidermis
[Term]
id: CL:0000723
name: somatic stem cell
def: "A stem cell that can give rise to cell types of the body other than those of the germ-line." [GO:0048103]
subset: cellxgene_subset
xref: CALOHA:TS-2086
xref: MESH:D053687
xref: ZFA:0009307 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000034 ! stem cell
intersection_of: CL:0000034 ! stem cell
intersection_of: capable_of GO:0048103 ! somatic stem cell division
relationship: capable_of GO:0048103 ! somatic stem cell division
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000723" xsd:string {name="somatic stem cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000731
name: urothelial cell
def: "A cell of a layer of transitional epithelium in the wall of the proximal urethra, bladder, ureter or renal pelvis, external to the lamina propria." [doi:10.1038/s41385-022-00565-0, GOC:tfm, MA:ma]
subset: cellxgene_subset
synonym: "urinary tract transitional epithelial cell" NARROW []
xref: FMA:84127
xref: ZFA:0009308 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000244 ! transitional epithelial cell
intersection_of: CL:0000244 ! transitional epithelial cell
intersection_of: part_of UBERON:0000365 ! urothelium
relationship: part_of UBERON:0000365 ! urothelium
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000731" xsd:string {name="urothelial cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000737
name: striated muscle cell
def: "Muscle cell which has as its direct parts myofilaments organized into sarcomeres." [GOC:tfm, ISBN:0721662544]
xref: BTO:0002916
xref: CALOHA:TS-2157
xref: FMA:86936
xref: ZFA:0005784 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000187 ! muscle cell
intersection_of: CL:0000187 ! muscle cell
intersection_of: has_part GO:0030017 ! sarcomere
intersection_of: RO:0000053 PATO:0001410 ! has characteristic striated
disjoint_from: CL:0008000 ! non-striated muscle cell
relationship: has_part GO:0030017 ! sarcomere
relationship: RO:0000053 PATO:0001410 ! has characteristic striated
[Term]
id: CL:0000738
name: leukocyte
def: "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [GOC:add, GOC:tfm, ISBN:978-0-323-05290-0]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "immune cell" RELATED []
synonym: "leucocyte" EXACT []
synonym: "white blood cell" EXACT []
xref: BTO:0000751
xref: CALOHA:TS-0549
xref: FMA:62852
xref: MESH:D007962
xref: NCIT:C12529
xref: ZFA:0009309 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000219 ! motile cell
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: capable_of GO:0001667 ! ameboidal-type cell migration
intersection_of: RO:0000053 PATO:0002505 ! has characteristic nucleated
relationship: capable_of GO:0001667 ! ameboidal-type cell migration
relationship: develops_from CL:0000037 ! hematopoietic stem cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of UBERON:0002405 ! immune system
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0000053 PATO:0002505 ! has characteristic nucleated
[Term]
id: CL:0000740
name: retinal ganglion cell
def: "The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve." [GOC:dph]
subset: cellxgene_subset
subset: eye_upper_slim
subset: human_reference_atlas
synonym: "gangliocyte" EXACT []
synonym: "ganglion cell of retina" EXACT []
synonym: "RGC" RELATED OMO:0003000 [doi:10.1038/s41598-020-66092-9]
synonym: "RGCs" RELATED OMO:0003004 [doi:10.1038/s41598-020-66092-9]
xref: BTO:0001800
xref: FMA:67765
xref: MESH:D012165
xref: ZFA:0009310 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000540 ! neuron
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002100 UBERON:0000966 ! has soma location retina
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000740" xsd:string {name="retinal ganglion cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000743
name: hypertrophic chondrocyte
def: "A chondrocyte that is part of the hypertrophic cartilage zone. This cell is significantly enlarged and characterised by high expression of type X collagen (COL10A1) in both humans and mice. It actively coordinates endochondral ossification by mineralising the extracellular matrix, attracting blood vessels via angiogenic signalling, and mediating the transition from cartilage to bone - often by transdifferentiating into an osteoblast rather than undergoing apoptosis." [GO_REF:0000034, PMID:15951842, PMID:25321476, PMID:35179487]
comment: Despite historical descriptions as 'terminally differentiated,' hypertrophic chondrocytes survive and transdifferentiate into osteoblasts. Genetic lineage tracing shows that hypertrophic chondrocytes do not simply undergo apoptosis but cross the cartilage–bone boundary, dedifferentiate into skeletal stem/progenitor cells, and then redifferentiate into osteoblasts and osteocytes. Single-cell RNA-seq further indicates that these chondrocyte-derived SSPCs are a major source of trabecular osteoblasts and marrow adipocytes. {xref="PMID:35179487"}
subset: cellxgene_subset
subset: human_reference_atlas
xref: ZFA:0009313 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000138 ! chondrocyte
is_a: CL:0001035 ! bone cell
intersection_of: CL:0000138 ! chondrocyte
intersection_of: part_of UBERON:0008187 ! hypertrophic cartilage zone
relationship: capable_of GO:0001958 ! endochondral ossification
relationship: part_of UBERON:0008187 ! hypertrophic cartilage zone
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002292 PR:000005693 ! expresses collagen alpha-1(X) chain
[Term]
id: CL:0000745
name: retina horizontal cell
def: "A neuron that laterally connects other neurons in the inner nuclear layer of the retina." [ISBN:0195088433]
subset: cellxgene_subset
subset: eye_upper_slim
subset: human_reference_atlas
synonym: "HC" RELATED OMO:0003000 [doi:10.1038/s41598-020-66092-9]
synonym: "HCs" RELATED OMO:0003004 [doi:10.1038/s41598-020-66092-9]
synonym: "horizontal cell" EXACT []
xref: BTO:0004120
xref: ZFA:0009315 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000099 ! interneuron
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002100 UBERON:0003902 ! has soma location retinal neural layer
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000745" xsd:string {name="retina horizontal cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000746
name: cardiac muscle cell
def: "Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei." [GOC:mtg_cardiacconduct_nov11, GOC:tfm, ISBN:0323052908, PMID:22426062, PMID:4711263]
comment: This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods. The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein). According to these refs, the cells participating in heart contraction in all cases are transversely striated. Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "cardiac muscle fiber" EXACT [GO:0048739]
synonym: "cardiac myocyte" EXACT []
synonym: "cardiocyte" BROAD []
synonym: "cardiomyocyte" EXACT []
synonym: "heart muscle cell" EXACT []
xref: BTO:0001539
xref: CALOHA:TS-0115
xref: FMA:14067
xref: MESH:D032383
xref: ZFA:0009316 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000737 ! striated muscle cell
is_a: CL:0002494 ! cardiocyte
intersection_of: CL:0000187 ! muscle cell
intersection_of: has_part GO:0030017 ! sarcomere
intersection_of: part_of UBERON:0007100 ! primary circulatory organ
intersection_of: participates_in GO:0060047 ! heart contraction
intersection_of: RO:0000053 PATO:0002478 ! has characteristic transversely striated
relationship: develops_from CL:0000513 ! cardiac muscle myoblast
relationship: has_part GO:0030017 ! sarcomere
relationship: part_of UBERON:0007100 ! primary circulatory organ
relationship: participates_in GO:0060047 ! heart contraction
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0000053 PATO:0002478 ! has characteristic transversely striated
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000746" xsd:string {name="cardiac muscle cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000748
name: retinal bipolar neuron
def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer." [PMID:14689473]
subset: cellxgene_subset
subset: eye_upper_slim
subset: human_reference_atlas
synonym: "BC" RELATED OMO:0003000 [doi:10.1038/s41598-020-66092-9]
synonym: "BCs" RELATED OMO:0003004 [doi:10.1038/s41598-020-66092-9]
synonym: "BPs" RELATED OMO:0003004 [geo:GSE137537]
xref: ZFA:0009318 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000679 ! glutamatergic neuron
is_a: CL:0008028 ! visual system neuron
is_a: CL:0009004 ! retinal cell
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0001791 ! has soma location inner nuclear layer of retina
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002100 UBERON:0001791 ! has soma location inner nuclear layer of retina
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000748" xsd:string {name="retinal bipolar neuron on CELLxGENE CellGuide"}
[Term]
id: CL:0000752
name: cone retinal bipolar cell
def: "A bipolar neuron found in the retina and having connections with cone photoreceptor cells and neurons in the inner plexiform layer." [PMID:14689473]
comment: The marker set COL19A1, DOK5 can identify the Human cell type http://purl.obolibrary.org/obo/CL_0000752 in the retina with a confidence of 0.843060252 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"}
subset: cellxgene_subset
xref: ZFA:0009322 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000748 ! retinal bipolar neuron
intersection_of: CL:0000748 ! retinal bipolar neuron
intersection_of: synapsed_by CL:0000573 ! retinal cone cell
relationship: part_of RO:0002577 ! system
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0015004 CLM:1001241 ! has characterizing marker set
relationship: RO:0015004 CLM:1001261 ! has characterizing marker set
relationship: synapsed_by CL:0000573 ! retinal cone cell
[Term]
id: CL:0000762
name: nucleated thrombocyte
def: "A nucleated blood cell involved in coagulation, typically seen in birds and other non-mammalian vertebrates." [GOC:add, GOC:tfm, PMID:16360205]
comment: Note that this is a non-mammalian cell type. Use platelet ; CL:0000233 for thrombocytes (platelets) in mammals.
subset: blood_and_immune_upper_slim
xref: ZFA:0009323 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000226 ! single nucleate cell
is_a: CL:0000763 {is_inferred="true"} ! myeloid cell
intersection_of: CL:0000763 ! myeloid cell
intersection_of: capable_of GO:0007596 ! blood coagulation
intersection_of: RO:0000053 PATO:0001407 ! has characteristic mononucleate
relationship: capable_of GO:0007596 ! blood coagulation
relationship: develops_from CL:0000828 ! thromboblast
relationship: RO:0000053 PATO:0001407 ! has characteristic mononucleate
[Term]
id: CL:0000763
name: myeloid cell
def: "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." [GOC:add]
subset: cellxgene_subset
xref: BTO:0001441
xref: CALOHA:TS-0647
xref: MESH:D022423
xref: ZFA:0009324 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: develops_from CL:0000049 ! common myeloid progenitor
relationship: develops_from CL:0000049 ! common myeloid progenitor
[Term]
id: CL:0000764
name: erythroid lineage cell
def: "A immature or mature cell in the lineage leading to and including erythrocytes." [GOC:add, GOC:tfm]
comment: Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "erythropoietic cell" EXACT []
xref: CALOHA:TS-0290
xref: FMA:62845
xref: FMA:83516
xref: ZFA:0009325 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000763 ! myeloid cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000765
name: erythroblast
def: "A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers." [GOC:add, ISBN:0721601464, PMID:18174176]
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
synonym: "normoblast" EXACT []
xref: BTO:0001571
xref: CALOHA:TS-0289
xref: FMA:83504
xref: MESH:D004900
xref: ZFA:0005237 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0000764 ! erythroid lineage cell
intersection_of: capable_of GO:0030218 ! erythrocyte differentiation
intersection_of: CL:4030045 GO:0005730 ! lacks_part nucleolus
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
intersection_of: has_part GO:0005634 ! nucleus
relationship: capable_of GO:0030218 ! erythrocyte differentiation
relationship: CL:4030045 GO:0005730 ! lacks_part nucleolus
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
relationship: develops_from CL:0000547 ! proerythroblast
relationship: has_part GO:0005634 ! nucleus
[Term]
id: CL:0000766
name: myeloid leukocyte
def: "A cell of the monocyte, granulocyte, or mast cell lineage." [GOC:add]
subset: cellxgene_subset
xref: ZFA:0009326 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000738 {is_inferred="true"} ! leukocyte
is_a: CL:0000763 ! myeloid cell
intersection_of: CL:0000738 ! leukocyte
intersection_of: develops_from CL:0000049 ! common myeloid progenitor
relationship: develops_from CL:0000049 ! common myeloid progenitor
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000766" xsd:string {name="myeloid leukocyte on CELLxGENE CellGuide"}
[Term]
id: CL:0000775
name: neutrophil
def: "Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." [GOC:add, GOC:amm, GOC:tfm, ISBN:0721601464]
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "neutrocyte" EXACT []
synonym: "neutrophil leucocyte" EXACT []
synonym: "neutrophil leukocyte" EXACT []
synonym: "neutrophilic leucocyte" EXACT []
synonym: "neutrophilic leukocyte" EXACT []
synonym: "PMN" BROAD []
synonym: "poly" BROAD []
synonym: "polymorphonuclear leucocyte" BROAD []
synonym: "polymorphonuclear leukocyte" BROAD []
synonym: "polymorphonuclear neutrophil" BROAD []
synonym: "polynuclear neutrophilic leucocyte" BROAD []
synonym: "polynuclear neutrophilic leukocyte" BROAD []
xref: BTO:0000130
xref: CALOHA:TS-0688
xref: FMA:62860
xref: MESH:D009504
xref: ZFA:0009327 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000094 {is_inferred="true"} ! granulocyte
intersection_of: CL:0000094 ! granulocyte
intersection_of: RO:0002104 PR:000001479 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor II
intersection_of: RO:0002104 PR:000001879 ! has plasma membrane part leukosialin
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 PR:000001479 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor II
relationship: RO:0002104 PR:000001879 ! has plasma membrane part leukosialin
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000775" xsd:string {name="neutrophil on CELLxGENE CellGuide"}
[Term]
id: CL:0000777
name: mesangial phagocyte
def: "A tissue-resident macrophage of the renal glomerular mesangium involved in the disposal and degradation of filtration residues, presentation of antigen to T cells and in tissue remodeling." [GOC:add, GOC:tfm, ISBN:0702022918, ISBN:3540536663, PMID:1600140, PMID:16146841]
synonym: "mesangial cell" BROAD []
is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage
intersection_of: CL:0000864 ! tissue-resident macrophage
intersection_of: capable_of GO:0019882 ! antigen processing and presentation
intersection_of: capable_of GO:0048771 ! tissue remodeling
intersection_of: located_in UBERON:0002320 ! glomerular mesangium
relationship: capable_of GO:0019882 ! antigen processing and presentation
relationship: capable_of GO:0048771 ! tissue remodeling
relationship: located_in UBERON:0002320 ! glomerular mesangium
[Term]
id: CL:0000778
name: mononuclear osteoclast
def: "A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts." [GOC:add, GOC:tfm, PMID:12713016, PMID:15055519, PMID:17380158, PMID:9415452]
comment: Morphology: mononuclear, highly vesicular.
xref: ZFA:0009329 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000092 {is_inferred="true"} ! osteoclast
is_a: CL:0000113 ! mononuclear phagocyte
intersection_of: CL:0000092 ! osteoclast
intersection_of: RO:0000053 PATO:0001407 ! has characteristic mononucleate
relationship: RO:0000053 PATO:0001407 ! has characteristic mononucleate
[Term]
id: CL:0000779
name: multinuclear osteoclast
def: "A specialized multinuclear osteoclast, forming a syncytium through the fusion of mononuclear precursor cells, associated with the absorption and removal of bone." [GOC:add, PMID:12713016, PMID:29379067, PMID:38903088, PMID:9415452]
comment: Morphology: multinucleated, highly vesicular.
synonym: "multinucleated osteoclast" EXACT []
is_a: CL:0000092 {is_inferred="true"} ! osteoclast
is_a: CL:0000783 ! multinucleated phagocyte
is_a: CL:4052002 ! syncytial cell
intersection_of: CL:0000092 ! osteoclast
intersection_of: RO:0000053 PATO:0001908 ! has characteristic multinucleate
relationship: develops_from CL:0000778 ! mononuclear osteoclast
relationship: RO:0000053 PATO:0001908 ! has characteristic multinucleate
[Term]
id: CL:0000780
name: multinuclear odontoclast
def: "A specialized multinuclear osteoclast associated with the absorption and removal of cementum." [GOC:add, PMID:9415452]
comment: Morphology: multinucleated, highly vesicular; location: roots of deciduous (milk) teeth.
synonym: "multinucleated odontoclast" EXACT []
is_a: CL:0000588 {is_inferred="true"} ! odontoclast
is_a: CL:0000779 ! multinuclear osteoclast
intersection_of: CL:0000588 ! odontoclast
intersection_of: RO:0000053 PATO:0001908 ! has characteristic multinucleate
relationship: develops_from CL:0000781 ! mononuclear odontoclast
relationship: RO:0000053 PATO:0001908 ! has characteristic multinucleate
[Term]
id: CL:0000781
name: mononuclear odontoclast
def: "A specialized mononuclear osteoclast associated with the absorption and removal of cementum." [GOC:add, PMID:9415452]
comment: Morphology: Mononuclear, highly vesicular; location: roots of deciduous (milk) teeth.
xref: ZFA:0009330 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000588 {is_inferred="true"} ! odontoclast
is_a: CL:0000778 {is_inferred="true"} ! mononuclear osteoclast
intersection_of: CL:0000588 ! odontoclast
intersection_of: RO:0000053 PATO:0001407 ! has characteristic mononucleate
relationship: RO:0000053 PATO:0001407 ! has characteristic mononucleate
[Term]
id: CL:0000782
name: myeloid dendritic cell
def: "A dendritic cell of the myeloid lineage." [GOC:add, PMID:10449155, PMID:17332250, PMID:9521319]
comment: These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8).
subset: cellxgene_subset
synonym: "CD11c+CD123- DC" EXACT []
synonym: "interdigitating cell" BROAD []
synonym: "mDC" EXACT []
synonym: "veiled cell" BROAD []
xref: BTO:0004721
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleukin-3 receptor class 2 alpha chain
intersection_of: develops_from CL:0000763 ! myeloid cell
relationship: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleukin-3 receptor class 2 alpha chain
relationship: develops_from CL:0000763 ! myeloid cell
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000782" xsd:string {name="myeloid dendritic cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000783
name: multinucleated phagocyte
def: "A phagocyte formed by the fusion of mononuclear phagocytes." [GOC:add, GOC:tfm]
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0000518 {is_inferred="true"} ! phagocyte (sensu Vertebrata)
intersection_of: CL:0000518 ! phagocyte (sensu Vertebrata)
intersection_of: RO:0000053 PATO:0001908 ! has characteristic multinucleate
relationship: RO:0000053 PATO:0001908 ! has characteristic multinucleate
[Term]
id: CL:0000785
name: mature B cell
def: "A B cell that is mature, having left the bone marrow. Initially, these cells are IgM-positive and IgD-positive, and they can be activated by antigen." [GOC:add, GOC:dsd, ISBN:0781735149]
comment: Mature B cells are also reportedly CD10-negative, CD19-positive, CD22-positive, CD34-negative, CD48-positive, CD79a-positive, CD84-positive, CD127-negative, CD352-positive, RAG-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Transcription factors expressed: Pax5-positive.
subset: cellxgene_subset
synonym: "mature B lymphocyte" EXACT []
synonym: "mature B-cell" EXACT []
synonym: "mature B-lymphocyte" EXACT []
xref: ZFA:0009331 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000145 ! professional antigen presenting cell
is_a: CL:0001201 {is_inferred="true"} ! B cell, CD19-positive
intersection_of: CL:0001201 ! B cell, CD19-positive
intersection_of: capable_of GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
intersection_of: capable_of GO:0042113 ! B cell activation
intersection_of: output_of GO:0002335 ! mature B cell differentiation
disjoint_from: CL:0000816 ! immature B cell
disjoint_from: CL:0000817 ! precursor B cell
disjoint_from: CL:0000818 ! transitional stage B cell
relationship: capable_of GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
relationship: capable_of GO:0042113 ! B cell activation
relationship: develops_from CL:0000818 ! transitional stage B cell
relationship: output_of GO:0002335 ! mature B cell differentiation
[Term]
id: CL:0000786
name: plasma cell
def: "A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin." [GO_REF:0000031, GOC:add, GOC:dsd, http://en.wikipedia.org/wiki/Plasma_cell, ISBN:0721601464, ISBN:0781735149, PMID:19447676, PMID:20081059, PMID:20839338, PMID:20951740]
comment: Plasma cells develop in the spleen and migrate to the bone marrow. Plasma cells are also reportedly CD5-negative, CD10-negative, CD19-positive, CD20-negative, CD21-negative, CD22-negative, CD23-negative, CD24-negative, CD25-negative, CD27-positive, CD34-negative, CD38-positive, CD40-positive, CD43-positive, CD45-positive, CD48-positive, CD53-low, CD80-negative, CD81-positive, CD86-positive, CD95-positive, CD196-negative, CD229-positive, CD270-positive, CD352-positive, CD361-positive, and IgD-negative. Transcription factors: BLIMP1-positive, IRF4-positive, PAX5-negative, SpiB-negative, Ets1-negative, and XBP1-positive.
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "effector B cell" RELATED []
synonym: "effector B-cell" RELATED []
synonym: "plasma B cell" EXACT []
synonym: "plasma B-cell" EXACT []
synonym: "plasmacyte" EXACT []
synonym: "plasmocyte" EXACT []
xref: BTO:0000392
xref: FMA:70574
xref: MESH:D010950
xref: ZFA:0009332 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000946 {is_inferred="true"} ! antibody secreting cell
intersection_of: CL:0000946 ! antibody secreting cell
intersection_of: CL:4030046 GO:0019814 ! lacks_plasma_membrane_part immunoglobulin complex
intersection_of: CL:4030046 GO:0042613 ! lacks_plasma_membrane_part MHC class II protein complex
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: has_part CL:0017508 ! cartwheel heterochromatin
intersection_of: has_part GO:0005794 ! Golgi apparatus
intersection_of: RO:0002104 PR:000001935 ! has plasma membrane part syndecan-1
relationship: CL:4030046 GO:0019814 ! lacks_plasma_membrane_part immunoglobulin complex
relationship: CL:4030046 GO:0042613 ! lacks_plasma_membrane_part MHC class II protein complex
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: develops_from CL:0000980 ! plasmablast
relationship: has_part CL:0017508 ! cartwheel heterochromatin
relationship: has_part GO:0005794 ! Golgi apparatus
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 PR:000001935 ! has plasma membrane part syndecan-1
[Term]
id: CL:0000787
name: memory B cell
def: "A memory B cell is a mature B cell that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin. This cell type has the phenotype CD19-positive, CD20-positive, MHC Class II-positive, and CD138-negative." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:rhs, http://en.wikipedia.org/wiki/Memory_B_cell, ISBN:0781735149, PMID:20081059, PMID:20839338]
comment: Memory B-cells are also reportedly CD5-negative, CD10-negative, CD21-positive, CD22-positive, CD23-negative, CD24-positive, CD25-positive, CD27-positive, CD34-negative, CD38-negative, CD40-positive, CD43-negative, CD44-positive, CD45-positive, CD53-positive, CD80-negative, CD81-negative, CD86-positive, and CD196/CCR6-positive.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "memory B lymphocyte" EXACT []
synonym: "memory B-cell" EXACT []
synonym: "memory B-lymphocyte" EXACT []
xref: ZFA:0009333 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000785 {is_inferred="true"} ! mature B cell
intersection_of: CL:0000785 ! mature B cell
intersection_of: CL:4030046 PR:000001935 ! lacks_plasma_membrane_part syndecan-1
intersection_of: output_of GO:0002344 ! B cell affinity maturation
intersection_of: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex
intersection_of: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001935 ! lacks_plasma_membrane_part syndecan-1
relationship: output_of GO:0002344 ! B cell affinity maturation
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex
relationship: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1
[Term]
id: CL:0000788
name: naive B cell
def: "A naive B cell is a mature B cell that has the phenotype surface IgD-positive, surface IgM-positive, CD20-positive, CD27-negative and that has not yet been activated by antigen in the periphery." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:rhs, ISBN:0781765196, PMID:19447676, PMID:20081059, PMID:20839338, PMID:20933013, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'naive B cell'. Per DSD: Naive B cells are also reportedly CD10-negative, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD25-negative, CD27-negative, CD34-negative, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD80-negative, CD81-positive, CD84-positive, CD86-negative, CD95-negative, CD138-negative, CD150-positive, CD184/CXCR4-positive, CD185/CXCR5-positive, CD196/CCR6-positive, CD200-positive, CD229-positive, CD243-positive, CD289-positive, CD290-positive, CD352-positive, MHCII/HLA-DR-positive, cadherin 9-positive, and sIgH-positive, Transcription factors: Pax5-positive, ETS1-positive, FOXO1A-positive, KLF4-positive, KLF9-positive, MiTF-positive, OBF1-positive, PLZF-positive, and SpiB-positive.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "naive B lymphocyte" EXACT []
synonym: "naive B-cell" EXACT []
synonym: "naive B-lymphocyte" EXACT []
xref: ZFA:0009334 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000785 {is_inferred="true"} ! mature B cell
intersection_of: CL:0000785 ! mature B cell
intersection_of: CL:4030044 GO:0002344 ! has_not_completed B cell affinity maturation
intersection_of: CL:4030046 PR:000001963 ! lacks_plasma_membrane_part CD27 molecule
intersection_of: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex
intersection_of: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex
intersection_of: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030044 GO:0002344 ! has_not_completed B cell affinity maturation
relationship: CL:4030046 PR:000001963 ! lacks_plasma_membrane_part CD27 molecule
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex
relationship: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex
relationship: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1
[Term]
id: CL:0000816
name: immature B cell
def: "An immature B cell is a B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:rhs, GOC:tfm, ISBN:0781735149, PMID:20081059, PMID:20839338]
comment: Immature B cells are also reportedly CD5-positive, CD10-positive, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD24-positive, CD25-negative, CD27-negative, CD34-negative, CD38-positive, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD79a-positive, CD80-negative, CD81-positive, CD86-negative, CD95-negative, CD127-negative, CD138-negative, CD185-positive, CD196-positive, MHCII/HLA-DR-positive, RAG-positive, TdT-negative, Vpre-B-negative, and preBCR-negative. Transcription factors expressed: Pax5-positive.
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "immature B lymphocyte" EXACT []
synonym: "immature B-cell" EXACT []
synonym: "immature B-lymphocyte" EXACT []
synonym: "newly formed B cell" EXACT [ISBN:781735149]
xref: ZFA:0009343 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0001201 ! B cell, CD19-positive
intersection_of: CL:0001201 ! B cell, CD19-positive
intersection_of: CL:4030044 GO:0045190 ! has_not_completed isotype switching
intersection_of: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex
intersection_of: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex
intersection_of: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030044 GO:0045190 ! has_not_completed isotype switching
relationship: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex
relationship: develops_from CL:0000954 ! small pre-B-II cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex
relationship: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1
[Term]
id: CL:0000817
name: precursor B cell
def: "A precursor B cell is a B cell with the phenotype CD10-positive." [GO_REF:0000031, GOC:rhs, GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "pre-B cell" RELATED []
xref: BTO:0001133
xref: CALOHA:TS-0819
xref: ZFA:0009344 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0001201 {is_inferred="true"} ! B cell, CD19-positive
intersection_of: CL:0001201 ! B cell, CD19-positive
intersection_of: CL:4030046 GO:0071753 ! lacks_plasma_membrane_part IgM immunoglobulin complex
intersection_of: RO:0002104 PR:000001898 ! has plasma membrane part neprilysin
disjoint_from: CL:0000826 ! pro-B cell
relationship: CL:4030046 GO:0071753 ! lacks_plasma_membrane_part IgM immunoglobulin complex
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 PR:000001898 ! has plasma membrane part neprilysin
[Term]
id: CL:0000818
name: transitional stage B cell
def: "An immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage with the phenotype surface IgM-positive and CD19-positive, and are subject to the process of B cell selection. A transitional B cell migrates from the bone marrow into the peripheral circulation, and then to the spleen." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12810111, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'transitional B cell'.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "T1 B cell" NARROW []
synonym: "T2 B cell" NARROW []
synonym: "T3 B cell" NARROW []
synonym: "transitional B cell" EXACT [PMID:22343568]
synonym: "transitional stage B lymphocyte" EXACT []
synonym: "transitional stage B-cell" EXACT []
synonym: "transitional stage B-lymphocyte" EXACT []
xref: ZFA:0009345 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0001201 {is_inferred="true"} ! B cell, CD19-positive
intersection_of: CL:0001201 ! B cell, CD19-positive
intersection_of: CL:4030044 GO:0002335 ! has_not_completed mature B cell differentiation
intersection_of: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex
intersection_of: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1
intersection_of: RO:0015015 PR:000001408 ! has high plasma membrane amount ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
intersection_of: RO:0015015 PR:000001932 ! has high plasma membrane amount signal transducer CD24
relationship: CL:4030044 GO:0002335 ! has_not_completed mature B cell differentiation
relationship: develops_from CL:0000816 ! immature B cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex
relationship: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1
relationship: RO:0015015 PR:000001408 ! has high plasma membrane amount ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
relationship: RO:0015015 PR:000001932 ! has high plasma membrane amount signal transducer CD24
[Term]
id: CL:0000819
name: B-1 B cell
def: "A B cell of distinct lineage and surface marker expression. B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas. These cells are CD43-positive." [GO_REF:0000031, GOC:add, GOC:dsd, http://en.wikipedia.org/wiki/B-1_cell, PMID:11861604, PMID:20933013, PMID:21220451]
comment: There are small numbers of B-1 cells found in the lymph nodes and spleen, while larger numbers can be found in the peritoneal and pleural cavities. B-1 B cells are reportedly CD11b-positive, CD20-positive, CD21-positive, CD27-positive, CD44-positive, CD45RB-positive, CD48-positive, CD70-negative, CD150-positive, CD244-negative, CD352-positive, sIgM-positive, and sIgD-low.
subset: cellxgene_subset
synonym: "B-1 B lymphocyte" EXACT []
synonym: "B-1 B-cell" EXACT []
synonym: "B-1 B-lymphocyte" EXACT []
synonym: "B-1 cell" EXACT []
synonym: "B1 B cell" EXACT []
synonym: "B1 B lymphocyte" EXACT []
synonym: "B1 B-cell" EXACT []
synonym: "B1 B-lymphocyte" EXACT []
synonym: "B1 cell" EXACT []
is_a: CL:0000785 {is_inferred="true"} ! mature B cell
intersection_of: CL:0000785 ! mature B cell
intersection_of: capable_of GO:0045087 ! innate immune response
intersection_of: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
intersection_of: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1
intersection_of: RO:0002104 PR:000001879 ! has plasma membrane part leukosialin
intersection_of: RO:0015015 GO:0071753 ! has high plasma membrane amount IgM immunoglobulin complex
relationship: capable_of GO:0045087 ! innate immune response
relationship: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
relationship: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1
relationship: RO:0002104 PR:000001879 ! has plasma membrane part leukosialin
relationship: RO:0015015 GO:0071753 ! has high plasma membrane amount IgM immunoglobulin complex
[Term]
id: CL:0000820
name: B-1a B cell
def: "A B-1 B cell that has the phenotype CD5-positive." [GOC:add, PMID:11861604]
subset: cellxgene_subset
synonym: "B-1a B lymphocyte" EXACT []
synonym: "B-1a B-cell" EXACT []
synonym: "B-1a B-lymphocyte" EXACT []
synonym: "B1a B cell" EXACT []
synonym: "B1a B lymphocyte" EXACT []
synonym: "B1a B-cell" EXACT []
synonym: "B1a B-lymphocyte" EXACT []
synonym: "B1a cell" EXACT []
synonym: "CD5(+) B1 cell" EXACT []
synonym: "CD5+ B1 cell" EXACT []
synonym: "CD5-positive B1 cell" EXACT []
is_a: CL:0000819 {is_inferred="true"} ! B-1 B cell
intersection_of: CL:0000819 ! B-1 B cell
intersection_of: RO:0002104 PR:000001839 ! has plasma membrane part T-cell surface glycoprotein CD5
relationship: RO:0002104 PR:000001839 ! has plasma membrane part T-cell surface glycoprotein CD5
[Term]
id: CL:0000821
name: B-1b B cell
def: "A B-1 B cell that has the phenotype CD5-negative, but having other phenotypic attributes of a B-1 B cell." [GOC:add, PMID:11861604]
subset: cellxgene_subset
synonym: "B-1b B lymphocyte" EXACT []
synonym: "B-1b B-cell" EXACT []
synonym: "B-1b B-lymphocyte" EXACT []
synonym: "B1b B cell" EXACT []
synonym: "B1b B lymphocyte" EXACT []
synonym: "B1b B-cell" EXACT []
synonym: "B1b B-lymphocyte" EXACT []
synonym: "B1b cell" EXACT []
is_a: CL:0000819 {is_inferred="true"} ! B-1 B cell
intersection_of: CL:0000819 ! B-1 B cell
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
[Term]
id: CL:0000822
name: B-2 B cell
def: "A conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells. These cells are CD43-negative." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0781735149, PMID:11861604, PMID:20933013]
comment: B-2 B cells are reportedly CD48-positive, CD244-negative, and CD352-positive.
subset: cellxgene_subset
synonym: "B-0 B cell" RELATED []
synonym: "B-2 B lymphocyte" EXACT []
synonym: "B-2 B-cell" EXACT []
synonym: "B-2 B-lymphocyte" EXACT []
synonym: "B2 B cell" EXACT []
synonym: "B2 B lymphocyte" EXACT []
synonym: "B2 B-cell" EXACT []
synonym: "B2 B-lymphocyte" EXACT []
synonym: "B2 cell" EXACT []
is_a: CL:0000785 {is_inferred="true"} ! mature B cell
intersection_of: CL:0000785 ! mature B cell
intersection_of: CL:4030046 PR:000001879 ! lacks_plasma_membrane_part leukosialin
intersection_of: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001879 ! lacks_plasma_membrane_part leukosialin
relationship: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1
[Term]
id: CL:0000823
name: immature natural killer cell
def: "A natural killer cell that is developmentally immature and expresses natural killer cell receptors (NKR)." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12457618]
comment: In mouse the NKR are Ly49 molecules and in human these cells express KIR molecules.
subset: cellxgene_subset
synonym: "immature NK cell" EXACT []
synonym: "p-NK" RELATED [PMID:12457618]
xref: ZFA:0009346 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000623 ! natural killer cell
is_a: CL:0001082 ! immature innate lymphoid cell
intersection_of: CL:0000623 ! natural killer cell
intersection_of: RO:0000053 PATO:0001501 ! has characteristic immature
disjoint_from: CL:0000937 ! pre-natural killer cell
relationship: develops_from CL:0000937 ! pre-natural killer cell
relationship: RO:0000053 PATO:0001501 ! has characteristic immature
[Term]
id: CL:0000825
name: pro-NK cell
def: "A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:11532393, PMID:12457618, PMID:15032583, PMID:15766674]
comment: Most markers only described for human pro NK cells.
synonym: "natural killer cell progenitor" EXACT []
synonym: "NKP" EXACT [PMID:12457618, PMID:15032583, PMID:15766674]
synonym: "null cell" RELATED [PMID:11532393]
synonym: "preNK cell" RELATED [PMID:11532393]
synonym: "pro-natural killer cell" EXACT []
xref: ZFA:0009348 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000838 {is_inferred="true"} ! lymphoid lineage restricted progenitor cell
intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell
intersection_of: CL:4030046 PR:000001874 ! lacks_plasma_membrane_part KLRB1-like protein
intersection_of: CL:4030046 PR:000002065 ! lacks_plasma_membrane_part mast/stem cell growth factor receptor
intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
intersection_of: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: RO:0002104 PR:000001381 ! has plasma membrane part interleukin-2 receptor subunit beta
intersection_of: RO:0002104 PR:000001898 ! has plasma membrane part neprilysin
relationship: CL:4030046 PR:000001874 ! lacks_plasma_membrane_part KLRB1-like protein
relationship: CL:4030046 PR:000002065 ! lacks_plasma_membrane_part mast/stem cell growth factor receptor
relationship: develops_from CL:0000051 ! common lymphoid progenitor
relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
relationship: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: RO:0002104 PR:000001381 ! has plasma membrane part interleukin-2 receptor subunit beta
relationship: RO:0002104 PR:000001898 ! has plasma membrane part neprilysin
[Term]
id: CL:0000826
name: pro-B cell
def: "A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs." [GOC:add, GOC:dsd, ISBN:0781735149, PMID:12633665, PMID:16551251, PMID:18432934]
comment: Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "pre-B cell (Philadelphia nomenclature)" RELATED [PMID:11244048]
synonym: "pre-pro B cell" BROAD [PMID:17582343]
synonym: "pro-B lymphocyte" EXACT []
synonym: "pro-B-cell" EXACT []
synonym: "pro-B-lymphocyte" EXACT []
synonym: "progenitor B cell" EXACT []
synonym: "progenitor B lymphocyte" EXACT []
synonym: "progenitor B-cell" EXACT []
synonym: "progenitor B-lymphocyte" EXACT []
xref: BTO:0003104
xref: ZFA:0009349 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000838 {is_inferred="true"} ! lymphoid lineage restricted progenitor cell
intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell
intersection_of: has_part PR:000001903 ! paired box protein PAX-5
intersection_of: has_part PR:000006611 ! DNA nucleotidylexotransferase
intersection_of: participates_in GO:0033152 ! immunoglobulin V(D)J recombination
relationship: develops_from CL:0000051 ! common lymphoid progenitor
relationship: has_part PR:000001903 ! paired box protein PAX-5
relationship: has_part PR:000006611 ! DNA nucleotidylexotransferase
relationship: participates_in GO:0033152 ! immunoglobulin V(D)J recombination
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000827
name: pro-T cell
def: "A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage." [GOC:add, ISBN:0781735149]
subset: cellxgene_subset
synonym: "DN1 cell" NARROW []
synonym: "DN1 thymocyte" NARROW []
synonym: "pro-T lymphocyte" EXACT []
synonym: "progenitor T cell" EXACT []
synonym: "TN1 cell" NARROW []
xref: ZFA:0009350 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000838 {is_inferred="true"} ! lymphoid lineage restricted progenitor cell
intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell
intersection_of: capable_of GO:0030217 ! T cell differentiation
relationship: capable_of GO:0030217 ! T cell differentiation
relationship: develops_from CL:0000051 ! common lymphoid progenitor
[Term]
id: CL:0000828
name: thromboblast
def: "A progenitor cell of the thrombocyte, a nucleated blood cell involved in coagulation typically seen in birds and other non-mammalian vertebrates." [GOC:add, GOC:tfm, PMID:7758949]
comment: Note that this is a non-mammalian cell type.
xref: ZFA:0009351 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000226 ! single nucleate cell
is_a: CL:0000763 ! myeloid cell
is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell
intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: capable_of GO:0002574 ! thrombocyte differentiation
intersection_of: RO:0000053 PATO:0001407 ! has characteristic mononucleate
relationship: capable_of GO:0002574 ! thrombocyte differentiation
relationship: develops_from CL:0000050 ! megakaryocyte-erythroid progenitor cell
relationship: RO:0000053 PATO:0001407 ! has characteristic mononucleate
[Term]
id: CL:0000834
name: neutrophil progenitor cell
def: "A progenitor cell of the neutrophil lineage." [GOC:add, GOC:tfm, ISBN:0721601464]
subset: cellxgene_subset
synonym: "neutrophil stem cell" RELATED []
xref: ZFA:0009352 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002191 {is_inferred="true"} ! granulocytopoietic cell
intersection_of: CL:0002191 ! granulocytopoietic cell
intersection_of: capable_of GO:0030223 ! neutrophil differentiation
relationship: capable_of GO:0030223 ! neutrophil differentiation
relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell
[Term]
id: CL:0000835
name: myeloblast
def: "The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow." [GOC:add, http://en.wikipedia.org/wiki/Myeloblast, http://www.cap.org, ISBN:0721601464]
xref: BTO:0000187
xref: FMA:83524
xref: ZFA:0009353 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002191 {is_inferred="true"} ! granulocytopoietic cell
intersection_of: CL:0002191 ! granulocytopoietic cell
intersection_of: CL:4030045 GO:0042582 ! lacks_part azurophil granule
intersection_of: has_part CL:0017503 ! basophilic cytoplasm
intersection_of: has_part GO:0000791 ! euchromatin
intersection_of: RO:0000053 PATO:0040072 ! has characteristic high nuclear/cytoplasmic ratio
relationship: CL:4030045 GO:0042582 ! lacks_part azurophil granule
relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell
relationship: has_part CL:0017503 ! basophilic cytoplasm
relationship: has_part GO:0000791 ! euchromatin
relationship: RO:0000053 PATO:0040072 ! has characteristic high nuclear/cytoplasmic ratio
[Term]
id: CL:0000837
name: hematopoietic multipotent progenitor cell
def: "A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans." [GOC:add, GOC:tfm, PMID:19022770]
comment: Markers differ between mouse and human.
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "hemopoietic progenitor cell" EXACT []
synonym: "MPP" EXACT []
xref: BTO:0000725
xref: CALOHA:TS-0448
xref: ZFA:0009354 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0008001 ! hematopoietic precursor cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha
intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
intersection_of: RO:0000053 PATO:0001402 ! has characteristic multipotent
intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
disjoint_from: CL:0002032 ! hematopoietic oligopotent progenitor cell
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha
relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
relationship: develops_from CL:0000037 ! hematopoietic stem cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0000053 PATO:0001402 ! has characteristic multipotent
relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
[Term]
id: CL:0000838
name: lymphoid lineage restricted progenitor cell
def: "A progenitor cell restricted to the lymphoid lineage." [GOC:add, GOC:tfm]
comment: Note that this is a class of cell types, not an identified single cell type.
subset: cellxgene_subset
synonym: "lymphoid progenitor cell" BROAD []
xref: BTO:0004731
xref: CALOHA:TS-2025
xref: FMA:70338
xref: ZFA:0009355 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0002031 {is_inferred="true"} ! hematopoietic lineage restricted progenitor cell
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell
intersection_of: capable_of GO:0030098 ! lymphocyte differentiation
disjoint_from: CL:0000839 ! myeloid lineage restricted progenitor cell
relationship: capable_of GO:0030098 ! lymphocyte differentiation
[Term]
id: CL:0000839
name: myeloid lineage restricted progenitor cell
def: "A progenitor cell restricted to the myeloid lineage." [GOC:add, GOC:tfm, PMID:19022770]
comment: Note that this is a class of cell types, not an identified single cell type.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "myeloid progenitor cell" BROAD []
xref: BTO:0004730
xref: CALOHA:TS-2099
xref: FMA:70339
xref: ZFA:0009356 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0002031 {is_inferred="true"} ! hematopoietic lineage restricted progenitor cell
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell
intersection_of: capable_of GO:0030099 ! myeloid cell differentiation
relationship: capable_of GO:0030099 ! myeloid cell differentiation
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000842
name: mononuclear leukocyte
def: "A leukocyte with a single non-segmented nucleus in the mature form." [GOC:add]
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
synonym: "mononuclear cell" EXACT []
synonym: "peripheral blood mononuclear cell" NARROW []
xref: BTO:0000878
xref: CALOHA:TS-0768
xref: FMA:86713
xref: ZFA:0009357 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000226 ! single nucleate cell
is_a: CL:0000738 {is_inferred="true"} ! leukocyte
intersection_of: CL:0000738 ! leukocyte
intersection_of: RO:0000053 PATO:0001407 ! has characteristic mononucleate
relationship: RO:0000053 PATO:0001407 ! has characteristic mononucleate
[Term]
id: CL:0000843
name: follicular B cell
def: "A resting mature B cell that has the phenotype IgM-positive, IgD-positive, CD23-positive and CD21-positive, and found in the B cell follicles of the white pulp of the spleen or the corticol areas of the peripheral lymph nodes. This cell type is also described as being CD19-positive, B220-positive, AA4-negative, CD43-negative, and CD5-negative." [GOC:add, GOC:dsd, http://en.wikipedia.org/wiki/Follicular_B_Cells, ISBN:0781735149, PMCID:PMC2193793, PMID:20933013]
comment: Follicular B cells are also reportedly CD48-positive, CD84-positive, CD229-positive, and CD352-positive.
subset: cellxgene_subset
synonym: "Fo B cell" EXACT []
synonym: "Fo B-cell" EXACT []
synonym: "follicular B lymphocyte" EXACT []
synonym: "follicular B-cell" EXACT []
synonym: "follicular B-lymphocyte" EXACT []
is_a: CL:0000822 ! B-2 B cell
intersection_of: CL:0000785 ! mature B cell
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
intersection_of: CL:4030046 PR:000001879 ! lacks_plasma_membrane_part leukosialin
intersection_of: CL:4030046 PR:000002037 ! lacks_plasma_membrane_part complement component C1q receptor
intersection_of: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex
intersection_of: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex
intersection_of: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
intersection_of: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1
intersection_of: RO:0002104 PR:000001338 ! has plasma membrane part complement receptor type 2
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001879 ! lacks_plasma_membrane_part leukosialin
relationship: CL:4030046 PR:000002037 ! lacks_plasma_membrane_part complement component C1q receptor
relationship: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex
relationship: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex
relationship: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
relationship: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1
relationship: RO:0002104 PR:000001338 ! has plasma membrane part complement receptor type 2
[Term]
id: CL:0000844
name: germinal center B cell
def: "A rapidly cycling mature B cell that has distinct phenotypic characteristics and is involved in T-dependent immune responses and located typically in the germinal centers of lymph nodes. This cell type expresses Ly77 after activation." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0781735149, PMID:19447676, PMID:20933013]
comment: Germinal center B cells are also reportedly CD10-positive, CD19-positive, CD20-positive, CD38-positive, CD44-low, CD45-positive, CD48-positive, CD95-positive, CD352-positive, and HLA-DR-positive. Transcription factors: BCL6-positive, Ets1-positive, IRF8-positive, MTA3-positive, OBF1-positive, PAX5-positive, SpiB-positive, and STAT3-positive.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "GC B cell" EXACT []
synonym: "GC B lymphocyte" EXACT []
synonym: "GC B-cell" EXACT []
synonym: "GC B-lymphocyte" EXACT []
synonym: "germinal center B lymphocyte" EXACT []
synonym: "germinal center B-cell" EXACT []
synonym: "germinal center B-lymphocyte" EXACT []
is_a: CL:0000785 {is_inferred="true"} ! mature B cell
intersection_of: CL:0000785 ! mature B cell
intersection_of: part_of UBERON:0010754 ! germinal center
intersection_of: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1
relationship: develops_from CL:0000843 ! follicular B cell
relationship: part_of UBERON:0010754 ! germinal center
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1
[Term]
id: CL:0000847
name: ciliated olfactory receptor neuron
def: "An olfactory receptor cell in which the apical ending of the dendrite is a pronounced ciliated olfactory knob." [PMID:16841163]
synonym: "ciliated olfactory sensory neuron" EXACT []
synonym: "ciliated sensory neuron" EXACT []
xref: ZFA:0009358 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000064 ! ciliated cell
is_a: CL:0000207 ! olfactory receptor cell
intersection_of: CL:0000207 ! olfactory receptor cell
intersection_of: has_part GO:0005929 ! cilium
relationship: has_part GO:0005929 ! cilium
[Term]
id: CL:0000848
name: microvillous olfactory receptor neuron
def: "An olfactory receptor cell in which the apical ending of the dendrite is a knob that bears numerous microvilli." [PMID:16841163]
synonym: "microvillous olfactory sensory neuron" EXACT []
synonym: "microvillous sensory neuron" RELATED []
xref: ZFA:0009359 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000207 ! olfactory receptor cell
[Term]
id: CL:0000850
name: serotonergic neuron
def: "A neuron that releases serotonin as a neurotransmitter." [SANBI:mhl]
subset: cellxgene_subset
synonym: "5-HT neuron" EXACT []
synonym: "5-hydroxytryptamine neuron" EXACT []
synonym: "serotinergic neuron" RELATED []
xref: FBbt:00005133 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
xref: MESH:D059326
xref: WBbt:0006837
xref: ZFA:0009361 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000458 ! serotonin secreting cell
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0060096 ! serotonin secretion, neurotransmission
relationship: capable_of GO:0060096 ! serotonin secretion, neurotransmission
[Term]
id: CL:0000853
name: olfactory epithelial supporting cell
def: "Olfactory epithelial support cell is a columnar cell that extends from the epithelial free margin to the basement membrane of the olfactory epithelium. This cell type has a large, vertically, elongate, euchromatic nucleus, along with other nuclei, forms a layer superficial to the cell body of the receptor cell; sends long somewhat irregular microvilli into the mucus layer; at the base, with expanded end-feet containing numerous lamellated dense bodies resembling lipofuscin of neurons." [GOC:tfm, ISBN:0517223651, SANBI:mhl]
synonym: "olfactory epithelial support cell" EXACT []
synonym: "olfactory sustentacular cell" EXACT []
synonym: "supporting cell of olfactory epithelium" EXACT []
synonym: "sustentaculocyte of olfactory epithelium" EXACT []
xref: FMA:62302
xref: ZFA:0009364 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000630 ! supporting cell
is_a: CL:0002167 ! olfactory epithelial cell
intersection_of: CL:0000630 ! supporting cell
intersection_of: part_of UBERON:0001997 ! olfactory epithelium
relationship: part_of UBERON:0001997 ! olfactory epithelium
[Term]
id: CL:0000855
name: sensory hair cell
def: "Hair cell is a mechanoreceptor cell that is sensitive to movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." [SANBI:mhl]
synonym: "hair cell" BROAD []
xref: BTO:0004744
xref: ZFA:0009366 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000199 ! mechanoreceptor cell
[Term]
id: CL:0000856
name: neuromast hair cell
def: "Neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." [SANBI:mhl]
xref: ZFA:0009367 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000855 ! sensory hair cell
intersection_of: CL:0000855 ! sensory hair cell
intersection_of: part_of UBERON:0008904 ! neuromast
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: part_of UBERON:0008904 ! neuromast
[Term]
id: CL:0000857
name: slow muscle myoblast
def: "A skeletal muscle myoblast that differentiates into slow muscle fibers." [SANBI:mhl]
xref: ZFA:0009368 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000515 ! skeletal muscle myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: develops_into CL:0000189 ! slow muscle cell
relationship: develops_into CL:0000189 ! slow muscle cell
[Term]
id: CL:0000858
name: fast muscle myoblast
def: "A skeletal muscle myoblast that differentiates into fast muscle fibers." [SANBI:mhl]
xref: ZFA:0009369 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000515 ! skeletal muscle myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: develops_into CL:0000190 ! fast muscle cell
relationship: develops_into CL:0000190 ! fast muscle cell
[Term]
id: CL:0000860
name: classical monocyte
def: "A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes." [GO_REF:0000031, GOC:add, PMID:16322748, PMID:18303997, PMID:20628149, PMID:20870168]
comment: Markers: CCR2+CXCCR1 (human, mouse, rat).
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "inflammatory monocyte" EXACT []
is_a: CL:0000576 {is_inferred="true"} ! monocyte
intersection_of: CL:0000576 ! monocyte
intersection_of: capable_of GO:0002548 ! monocyte chemotaxis
intersection_of: capable_of GO:0006909 ! phagocytosis
intersection_of: capable_of GO:0006954 ! inflammatory response
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: RO:0015015 PR:000001199 ! has high plasma membrane amount C-C chemokine receptor type 2
relationship: capable_of GO:0002548 ! monocyte chemotaxis
relationship: capable_of GO:0006909 ! phagocytosis
relationship: capable_of GO:0006954 ! inflammatory response
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0015015 PR:000001199 ! has high plasma membrane amount C-C chemokine receptor type 2
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000860" xsd:string {name="classical monocyte on CELLxGENE CellGuide"}
[Term]
id: CL:0000864
name: tissue-resident macrophage
def: "A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:ana, PMID:19770654]
subset: cellxgene_subset
synonym: "fixed macrophage" EXACT []
synonym: "resting histiocyte" EXACT []
xref: FMA:84642
xref: FMA:84644
is_a: CL:0000235 {is_inferred="true"} ! macrophage
intersection_of: CL:0000235 ! macrophage
intersection_of: part_of UBERON:0000479 ! tissue
relationship: part_of UBERON:0000479 ! tissue
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000864" xsd:string {name="tissue-resident macrophage on CELLxGENE CellGuide"}
[Term]
id: CL:0000878
name: central nervous system macrophage
def: "A tissue-resident macrophage found in the central nervous system." [GO_REF:0000031, PMID:16322748]
subset: cellxgene_subset
synonym: "CNS macrophage" EXACT []
is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000864 ! tissue-resident macrophage
intersection_of: part_of UBERON:0001017 ! central nervous system
relationship: part_of UBERON:0001017 ! central nervous system
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000878" xsd:string {name="central nervous system macrophage on CELLxGENE CellGuide"}
[Term]
id: CL:0000881
name: perivascular macrophage
def: "A border associated macrophage that is adjacent to a small blood vessel of a brain. A perivascular macrophage expresses the markers CD14, CD16 and CD163. In homeostatic conditions, this central nervous system macrophage has a non-motile cell body with extending and retracting projections through the blood vessel wall." [GO_REF:0000031, GOC:tfm, PMID:16507898, PMID:37232741]
subset: cellxgene_subset
synonym: "pvMΦ" RELATED OMO:0003000 [PMID:37232741]
is_a: CL:4033054 ! perivascular cell
is_a: CL:4042003 {is_inferred="true"} ! border associated macrophage
intersection_of: CL:4042003 ! border associated macrophage
intersection_of: part_of UBERON:0001981 ! blood vessel
intersection_of: RO:0002104 PR:000001483 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor III
intersection_of: RO:0002104 PR:000001889 ! has plasma membrane part CD14 molecule
intersection_of: RO:0002104 PR:000001925 ! has plasma membrane part scavenger receptor cysteine-rich type 1 protein M130
relationship: part_of UBERON:0001981 ! blood vessel
relationship: RO:0002104 PR:000001483 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor III
relationship: RO:0002104 PR:000001889 ! has plasma membrane part CD14 molecule
relationship: RO:0002104 PR:000001925 ! has plasma membrane part scavenger receptor cysteine-rich type 1 protein M130
[Term]
id: CL:0000889
name: myeloid suppressor cell
def: "An immature myeloid leukocyte of heterogeneous phenotype found particularly in cancer and sepsis patients that is capable of suppressing activity of T cells in ex vivo assays. This cell type is CD45-positive, CD11b-positive." [GO_REF:0000031, GOC:add, GOC:ana, PMID:16168663, PMID:17016554, PMID:17016559]
comment: Markers: Mouse: CD11b+GR1+CD31+; Human: CD34+ CD33+CD15-CD13+. (According to some reports in humans these cells are iNOS+ARG1+IL13+IFNg+); location: In cancerous tissue; in the blood and lymphoid organs in sepsis.
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte
intersection_of: CL:0000766 ! myeloid leukocyte
intersection_of: capable_of GO:0050777 ! negative regulation of immune response
intersection_of: RO:0000053 PATO:0001501 ! has characteristic immature
intersection_of: RO:0002104 PR:000001006 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C
intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
relationship: capable_of GO:0050777 ! negative regulation of immune response
relationship: RO:0000053 PATO:0001501 ! has characteristic immature
relationship: RO:0002104 PR:000001006 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C
relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
[Term]
id: CL:0000893
name: thymocyte
def: "An immature T cell located in the thymus." [GO_REF:0000031, GOC:add, GOC:tfm, PMID:12415312]
subset: cellxgene_subset
synonym: "immature T cell" BROAD []
synonym: "immature T lymphocyte" BROAD []
synonym: "immature T-cell" BROAD []
synonym: "immature T-lymphocyte" BROAD []
synonym: "thymic lymphocyte" EXACT []
xref: BTO:0001372
xref: CALOHA:TS-1042
xref: FMA:72202
xref: MESH:D060168
xref: XAO:0003159
is_a: CL:0002420 {is_inferred="true"} ! immature T cell
intersection_of: CL:0000084 ! T cell
intersection_of: CL:4030044 GO:0045058 ! has_not_completed T cell selection
intersection_of: part_of UBERON:0002370 ! thymus
relationship: CL:4030044 GO:0045058 ! has_not_completed T cell selection
relationship: part_of UBERON:0002370 ! thymus
[Term]
id: CL:0000894
name: DN1 thymic pro-T cell
def: "A pro-T cell that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:tfm]
synonym: "DN1 thymic pro-T lymphocyte" EXACT []
synonym: "DN1 thymic pro-T-cell" EXACT []
synonym: "DN1 thymic pro-T-lymphocyte" EXACT []
synonym: "DN1 thymic progenitor T cell" EXACT []
synonym: "DN1 thymocyte" EXACT []
synonym: "double negative 1" EXACT []
synonym: "preT.DN1.Th" EXACT []
is_a: CL:0000827 {is_inferred="true"} ! pro-T cell
intersection_of: CL:0000827 ! pro-T cell
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha
intersection_of: part_of UBERON:0002370 ! thymus
intersection_of: RO:0002104 PR:000001307 ! has plasma membrane part CD44 molecule
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha
relationship: develops_from CL:0002425 ! early T lineage precursor
relationship: part_of UBERON:0002370 ! thymus
relationship: RO:0002104 PR:000001307 ! has plasma membrane part CD44 molecule
[Term]
id: CL:0000936
name: early lymphoid progenitor
def: "A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:pam, GOC:tfm, PMID:19022770]
comment: Markers are associated with mouse cells. ELP transcription factors include E2A-positive, Ikaros-positive, EBF-negative, Pax5-negative, PU.1-negative.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "ELP" RELATED OMO:0003000 []
synonym: "GMLP" RELATED OMO:0003000 [PMID:18371378]
synonym: "LMPP" RELATED OMO:0003000 []
synonym: "lymphoid-primed multipotent progenitor" EXACT []
is_a: CL:0000837 {is_inferred="true"} ! hematopoietic multipotent progenitor cell
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell
intersection_of: capable_of GO:0030098 ! lymphocyte differentiation
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001460 ! lacks_plasma_membrane_part glycophorin-A
intersection_of: RO:0002104 PR:000002001 ! has plasma membrane part receptor-type tyrosine-protein kinase FLT3
intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor
intersection_of: RO:0002104 PR:000002979 ! has plasma membrane part lymphocyte antigen 6A-2/6E-1
relationship: capable_of GO:0030098 ! lymphocyte differentiation
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001460 ! lacks_plasma_membrane_part glycophorin-A
relationship: develops_from CL:0002035 ! Slamf1-negative multipotent progenitor cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 PR:000002001 ! has plasma membrane part receptor-type tyrosine-protein kinase FLT3
relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor
relationship: RO:0002104 PR:000002979 ! has plasma membrane part lymphocyte antigen 6A-2/6E-1
[Term]
id: CL:0000937
name: pre-natural killer cell
def: "Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, and CD117-positive. This cell type lacks expression of natural killer receptor proteins." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:pam, GOC:tfm, PMID:16551251, PMID:17100874]
comment: These cells are also reportedly CD7-low, CD10-negative, CD45RA-positive, alpha-4-beta-7 integrin-high.
subset: cellxgene_subset
synonym: "pre-NK cell" EXACT []
is_a: CL:0000623 ! natural killer cell
intersection_of: CL:0000623 ! natural killer cell
intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
intersection_of: RO:0002104 PR:000001381 ! has plasma membrane part interleukin-2 receptor subunit beta
intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor
relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
relationship: RO:0002104 PR:000001381 ! has plasma membrane part interleukin-2 receptor subunit beta
relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor
[Term]
id: CL:0000941
name: thymic conventional dendritic cell
def: "A dendritic cell arising in thymus that has the phenotype CD11c-positive, CD11b-negative, and CD45RA-negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:19273629]
comment: In the mouse this cell expresses CD8-alpha-alpha.
is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: part_of UBERON:0002370 ! thymus
intersection_of: RO:0002104 PR:000001013 ! has plasma membrane part integrin alpha-X
relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
relationship: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: develops_from CL:0000894 ! DN1 thymic pro-T cell
relationship: part_of UBERON:0002370 ! thymus
relationship: RO:0002104 PR:000001013 ! has plasma membrane part integrin alpha-X
[Term]
id: CL:0000945
name: lymphocyte of B lineage
def: "A lymphocyte of B lineage with the commitment to express an immunoglobulin complex." [GO_REF:0000031, GOC:add, GOC:rhs, GOC:tfm, ISBN:0781735149]
comment: Types of B lineage lymphocytes include B cells and antibody secreting cells (plasmablasts and plasma cells). Lymphocytes of B cell lineage can be distinguished from those of T cell lineage by their lack of CD3e (as part of the T cell receptor complex).
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:0000542 {is_inferred="true"} ! lymphocyte
relationship: develops_from CL:0000826 ! pro-B cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000946
name: antibody secreting cell
def: "A lymphocyte of B lineage that is devoted to secreting large amounts of immunoglobulin." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0721601464, ISBN:0781735149]
subset: cellxgene_subset
is_a: CL:0000945 {is_inferred="true"} ! lymphocyte of B lineage
intersection_of: CL:0000945 ! lymphocyte of B lineage
intersection_of: produces GO:0042571 ! immunoglobulin complex, circulating
relationship: produces GO:0042571 ! immunoglobulin complex, circulating
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000946" xsd:string {name="antibody secreting cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000948
name: IgE memory B cell
def: "A class switched memory B cell that expresses IgE on the cell surface." [GO_REF:0000031, GOC:rhs, ISBN:0781765196]
synonym: "IgE memory B lymphocyte" EXACT []
synonym: "IgE memory B-cell" EXACT []
synonym: "IgE memory B-lymphocyte" EXACT []
synonym: "memory IgE B cell" EXACT []
synonym: "memory IgE B lymphocyte" EXACT []
synonym: "memory IgE B-cell" EXACT []
synonym: "memory IgE B-lymphocyte" EXACT []
is_a: CL:4052108 ! IgD-negative class switched memory B cell
intersection_of: CL:0000972 ! class switched memory B cell
intersection_of: RO:0002104 GO:0071742 ! has plasma membrane part IgE immunoglobulin complex
relationship: RO:0002104 GO:0071742 ! has plasma membrane part IgE immunoglobulin complex
[Term]
id: CL:0000952
name: preBCR-positive large pre-B-II cell
def: "An preBRC-positive large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-positive, composed of surrogate light chain protein (SL), which is composed of VpreB , Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu) on the cell surface." [GO_REF:0000031, GOC:rhs, GOC:tfm, PMID:9785673]
is_a: CL:0000957 {is_inferred="true"} ! large pre-B-II cell
intersection_of: CL:0000957 ! large pre-B-II cell
intersection_of: CL:4030044 GO:0071708 ! has_not_completed immunoglobulin light chain V-J recombination
intersection_of: RO:0002104 GO:0035369 ! has plasma membrane part pre-B cell receptor complex
intersection_of: RO:0002104 PR:000001858 ! has plasma membrane part immunoglobulin iota chain
intersection_of: RO:0002104 PR:000001859 ! has plasma membrane part immunoglobulin lambda-like polypeptide 1
relationship: CL:4030044 GO:0071708 ! has_not_completed immunoglobulin light chain V-J recombination
relationship: RO:0002104 GO:0035369 ! has plasma membrane part pre-B cell receptor complex
relationship: RO:0002104 PR:000001858 ! has plasma membrane part immunoglobulin iota chain
relationship: RO:0002104 PR:000001859 ! has plasma membrane part immunoglobulin lambda-like polypeptide 1
[Term]
id: CL:0000953
name: preBCR-negative large pre-B-II cell
def: "A pre-BCR-negative large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-negative, composed of surrogate light chain protein (SL), which is composed of VpreB and Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu), on the cell surface, and lack a DNA rearrangement of immunoglobulin light chain genes." [GO_REF:0000031, GOC:rhs, GOC:tfm, PMID:9785673]
is_a: CL:0000957 {is_inferred="true"} ! large pre-B-II cell
intersection_of: CL:0000957 ! large pre-B-II cell
intersection_of: CL:4030044 GO:0071708 ! has_not_completed immunoglobulin light chain V-J recombination
intersection_of: CL:4030046 GO:0035369 ! lacks_plasma_membrane_part pre-B cell receptor complex
intersection_of: CL:4030046 PR:000001858 ! lacks_plasma_membrane_part immunoglobulin iota chain
intersection_of: CL:4030046 PR:000001859 ! lacks_plasma_membrane_part immunoglobulin lambda-like polypeptide 1
relationship: CL:4030044 GO:0071708 ! has_not_completed immunoglobulin light chain V-J recombination
relationship: CL:4030046 GO:0035369 ! lacks_plasma_membrane_part pre-B cell receptor complex
relationship: CL:4030046 PR:000001858 ! lacks_plasma_membrane_part immunoglobulin iota chain
relationship: CL:4030046 PR:000001859 ! lacks_plasma_membrane_part immunoglobulin lambda-like polypeptide 1
[Term]
id: CL:0000954
name: small pre-B-II cell
def: "A small pre-B-II cell is a pre-B-II cell that is Rag1-positive, Rag2-positive, pre-BCR-negative, and BCR-negative, is not proliferating, and carries a DNA rearrangement of one or more immunoglobulin light chain genes." [GO_REF:0000031, GOC:dsd, GOC:rhs, GOC:tfm, PMID:16551251, PMID:18432934, PMID:9785673]
comment: Small pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-negative, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive.
subset: cellxgene_subset
synonym: "small pre-BII cell" EXACT []
is_a: CL:0000955 {is_inferred="true"} ! pre-B-II cell
intersection_of: CL:0000955 ! pre-B-II cell
intersection_of: CL:4030046 GO:0019815 ! lacks_plasma_membrane_part B cell receptor complex
intersection_of: CL:4030046 GO:0035369 ! lacks_plasma_membrane_part pre-B cell receptor complex
intersection_of: has_part PR:000003457 ! V(D)J recombination-activating protein 1
intersection_of: has_part PR:000003460 ! V(D)J recombination-activating protein 2
intersection_of: participates_in GO:0071708 ! immunoglobulin light chain V-J recombination
relationship: CL:4030046 GO:0019815 ! lacks_plasma_membrane_part B cell receptor complex
relationship: CL:4030046 GO:0035369 ! lacks_plasma_membrane_part pre-B cell receptor complex
relationship: has_part PR:000003457 ! V(D)J recombination-activating protein 1
relationship: has_part PR:000003460 ! V(D)J recombination-activating protein 2
relationship: participates_in GO:0071708 ! immunoglobulin light chain V-J recombination
[Term]
id: CL:0000955
name: pre-B-II cell
def: "A pre-B-II cell is a precursor B cell that expresses immunoglobulin mu heavy chain (IgHmu+), and lack expression of CD34, TdT, immunoglobulin kappa light chain and immunoglobulin lambda light chain." [GO_REF:0000031, GOC:dsd, GOC:rhs, GOC:tfm, PMID:9785673]
comment: pre-B-II cell are also reportedly CD19-positive, CD22-positive, CD38-positive, CD45-positive, and CD48-positive.
synonym: "pre-B-lymphocyte" EXACT []
synonym: "pre-BII cell" EXACT []
xref: BTO:0001133
xref: CALOHA:TS-0819
is_a: CL:0000817 {is_inferred="true"} ! precursor B cell
intersection_of: CL:0000817 ! precursor B cell
intersection_of: CL:4030045 PR:000006611 ! lacks_part DNA nucleotidylexotransferase
intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule
intersection_of: output_of GO:0071707 ! immunoglobulin heavy chain V-D-J recombination
disjoint_from: CL:0000956 ! pre-B-I cell
relationship: CL:4030045 PR:000006611 ! lacks_part DNA nucleotidylexotransferase
relationship: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule
relationship: output_of GO:0071707 ! immunoglobulin heavy chain V-D-J recombination
[Term]
id: CL:0000956
name: pre-B-I cell
def: "A pre-B-I cell is a precursor B cell that expresses CD34 and surrogate immunoglobulin light chain (VpreB , Lambda 5 (mouse)/14.1 (human)) on the cell surface, and TdT, Rag1,and Rag2 intracellularly. Cell type carries a D-JH DNA rearrangement, and lacks expression of immunglobulin heavy chain protein." [GO_REF:0000031, GOC:dsd, GOC:rhs, GOC:tfm, PMID:16551251, PMID:18432934, PMID:20839338, PMID:9785673]
comment: Human pre-B-I cells are reportedly CD10-positive, CD19-positive, CD22-positive, CD38-positive, CD45-low, CD79a-positive, CD127-negative, pre-BCR-negative, IgM-negative, IgD-negative, and Tdt-positive. Transcription factors expressed: Pax5-positive.
subset: cellxgene_subset
synonym: "pre-BI cell" EXACT []
synonym: "pro-B cell (Philadelphia nomenclature)" RELATED [PMID:11244048]
is_a: CL:0000817 {is_inferred="true"} ! precursor B cell
intersection_of: CL:0000817 ! precursor B cell
intersection_of: has_part PR:000003457 ! V(D)J recombination-activating protein 1
intersection_of: has_part PR:000003460 ! V(D)J recombination-activating protein 2
intersection_of: has_part PR:000006611 ! DNA nucleotidylexotransferase
intersection_of: participates_in GO:0071707 ! immunoglobulin heavy chain V-D-J recombination
intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
intersection_of: RO:0002104 PR:000001858 ! has plasma membrane part immunoglobulin iota chain
intersection_of: RO:0002104 PR:000001859 ! has plasma membrane part immunoglobulin lambda-like polypeptide 1
relationship: has_part PR:000003457 ! V(D)J recombination-activating protein 1
relationship: has_part PR:000003460 ! V(D)J recombination-activating protein 2
relationship: has_part PR:000006611 ! DNA nucleotidylexotransferase
relationship: participates_in GO:0071707 ! immunoglobulin heavy chain V-D-J recombination
relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
relationship: RO:0002104 PR:000001858 ! has plasma membrane part immunoglobulin iota chain
relationship: RO:0002104 PR:000001859 ! has plasma membrane part immunoglobulin lambda-like polypeptide 1
[Term]
id: CL:0000957
name: large pre-B-II cell
def: "A large pre-B-II cell is a pre-B-II cell that is proliferating and is Rag1-negative and Rag2-negative." [GO_REF:0000031, GOC:dsd, GOC:rhs, PMID:16551251, PMID:18432934, PMID:9785673]
comment: Large pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-positive, pre-BCR-positive, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive.
subset: cellxgene_subset
synonym: "large pre-B cell" BROAD [PMID:11244048]
synonym: "large pre-BII cell" EXACT []
is_a: CL:0000955 {is_inferred="true"} ! pre-B-II cell
intersection_of: CL:0000955 ! pre-B-II cell
intersection_of: CL:4030045 PR:000003457 ! lacks_part V(D)J recombination-activating protein 1
intersection_of: CL:4030045 PR:000003460 ! lacks_part V(D)J recombination-activating protein 2
intersection_of: participates_in GO:0046651 ! lymphocyte proliferation
relationship: CL:4030045 PR:000003457 ! lacks_part V(D)J recombination-activating protein 1
relationship: CL:4030045 PR:000003460 ! lacks_part V(D)J recombination-activating protein 2
relationship: participates_in GO:0046651 ! lymphocyte proliferation
[Term]
id: CL:0000961
name: Bm1 B cell
def: "A follicular B cell that is IgD-positive, CD23-negative, and CD38-negative. This naive cell type is activated in the extrafollicular areas through interaction with interdigitating dendritic cells and antigen-specific CD4-positive T cells." [GO_REF:0000031, GOC:dsd, GOC:msz, PMID:11564773, PMID:17992590, PMID:18432934, PMID:19350211, PMID:31681331, PMID:8006591]
comment: These cells are also reportedly CD10-negative, CD39-positive, CD44-positive, CD71-negative, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative.
synonym: "Bm1 B lymphocyte" EXACT []
synonym: "Bm1 B-cell" EXACT []
synonym: "Bm1 B-lymphocyte" EXACT []
is_a: CL:0000843 {is_inferred="true"} ! follicular B cell
intersection_of: CL:0000843 ! follicular B cell
intersection_of: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
intersection_of: CL:4030046 PR:000001880 ! lacks_plasma_membrane_part low affinity immunoglobulin epsilon Fc receptor
intersection_of: in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex
relationship: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
relationship: CL:4030046 PR:000001880 ! lacks_plasma_membrane_part low affinity immunoglobulin epsilon Fc receptor
relationship: in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex
[Term]
id: CL:0000962
name: Bm2 B cell
def: "A follicular B cell that is IgD-positive and CD23-positive and CD38-positive. This naive cell type is activated in the extrafollicular areas via interaction with dendritic cells and antigen specific T cells." [GO_REF:0000031, GOC:dsd, GOC:msz, PMID:11564773, PMID:17992590, PMID:18432934, PMID:19350211, PMID:31681331, PMID:8006591]
comment: These cells are also CD10-negative, CD39-positive, CD44-positive, CD71-negative, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative.
synonym: "Bm2 B lymphocyte" EXACT []
synonym: "Bm2 B-cell" EXACT []
synonym: "Bm2 B-lymphocyte" EXACT []
is_a: CL:0000843 {is_inferred="true"} ! follicular B cell
intersection_of: CL:0000843 ! follicular B cell
intersection_of: in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex
intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
intersection_of: RO:0002104 PR:000001880 ! has plasma membrane part low affinity immunoglobulin epsilon Fc receptor
relationship: develops_from CL:0000961 ! Bm1 B cell
relationship: in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex
relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
relationship: RO:0002104 PR:000001880 ! has plasma membrane part low affinity immunoglobulin epsilon Fc receptor
[Term]
id: CL:0000963
name: Bm3-delta B cell
def: "A germinal center B cell that develops from a Bm3 B cell. This cell has the phenotype IgM-negative, IgD-positive, and CD38-positive." [GO_REF:0000031, GOC:add, GOC:msz, GOC:tfm, PMID:9280752]
synonym: "Bm3-delta B lymphocyte" EXACT []
synonym: "Bm3-delta B-cell" EXACT []
synonym: "Bm3-delta B-lymphocyte" EXACT []
is_a: CL:0000844 {is_inferred="true"} ! germinal center B cell
intersection_of: CL:0000844 ! germinal center B cell
intersection_of: CL:4030046 GO:0071753 ! lacks_plasma_membrane_part IgM immunoglobulin complex
intersection_of: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex
intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
relationship: CL:4030046 GO:0071753 ! lacks_plasma_membrane_part IgM immunoglobulin complex
relationship: develops_from CL:0000965 ! Bm3 B cell
relationship: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex
relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
[Term]
id: CL:0000964
name: Bm2' B cell
def: "A germinal center B cell that founds a germinal center, and has the phenotype IgD-positive, CD38-positive, and CD23-negative." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMID:11564773, PMID:17992590, PMID:18432934, PMID:19350211, PMID:31681331, PMID:8006591]
comment: Bm2' B cells are also reportedly CD10-positive, CD39-negative, CD44-negative, CD71-positive, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative.
synonym: "Bm2' B lymphocyte" EXACT []
synonym: "Bm2' B-cell" EXACT []
synonym: "Bm2-prime B cell" EXACT []
synonym: "Bm2-prime B-lymphocyte" EXACT []
synonym: "germinal center founder cell" RELATED []
is_a: CL:0000844 {is_inferred="true"} ! germinal center B cell
intersection_of: CL:0000844 ! germinal center B cell
intersection_of: capable_of GO:0002634 ! regulation of germinal center formation
intersection_of: CL:4030046 PR:000001880 ! lacks_plasma_membrane_part low affinity immunoglobulin epsilon Fc receptor
intersection_of: in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex
intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
relationship: capable_of GO:0002634 ! regulation of germinal center formation
relationship: CL:4030046 PR:000001880 ! lacks_plasma_membrane_part low affinity immunoglobulin epsilon Fc receptor
relationship: develops_from CL:0000962 ! Bm2 B cell
relationship: in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex
relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
[Term]
id: CL:0000965
name: Bm3 B cell
def: "A germinal center B cell that is rapidly dividing and has the phenotype IgD-negative, CD38-positive, and CD77-positive. Somatic hypermutation of the immunoglobulin V gene region can occur during proliferation of this cell type." [GO_REF:0000031, GOC:dsd, GOC:msz, PMID:11564773, PMID:18432934, PMID:19350211, PMID:31681331, PMID:8006591]
comment: Bm3 B cells are also reportedly CD10-positive, CD23-negative, CD39-negative, CD44-negative, CD71-positive, and CD77-positive.
synonym: "Bm3 B lymphocyte" EXACT []
synonym: "Bm3 B-cell" EXACT []
synonym: "Bm3 B-lymphocyte" EXACT []
synonym: "centroblast" RELATED [PMID:8006591]
is_a: CL:0000844 {is_inferred="true"} ! germinal center B cell
intersection_of: CL:0000844 ! germinal center B cell
intersection_of: capable_of GO:0016446 ! somatic hypermutation of immunoglobulin genes
intersection_of: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex
intersection_of: in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
intersection_of: RO:0002104 PR:000003516 ! has plasma membrane part lactosylceramide 4-alpha-galactosyltransferase
relationship: capable_of GO:0016446 ! somatic hypermutation of immunoglobulin genes
relationship: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex
relationship: develops_from CL:0000964 ! Bm2' B cell
relationship: in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
relationship: RO:0002104 PR:000003516 ! has plasma membrane part lactosylceramide 4-alpha-galactosyltransferase
[Term]
id: CL:0000966
name: Bm4 B cell
def: "A germinal center B cell that has the phenotype CD77-negative, IgD-negative, and CD38-positive. These cells have undergone somatic mutation of the B cell receptor." [GO_REF:0000031, GOC:dsd, GOC:msz, PMID:11564773, PMID:18432934, PMID:19350211, PMID:31681331, PMID:8006591]
comment: Bm4 B cells are also reportedly CD10-positive, CD23-negative, CD39-negative, CD44-positive, and CD71-positive.
synonym: "Bm4 B lymphocyte" EXACT []
synonym: "Bm4 B-cell" EXACT []
synonym: "Bm4 B-lymphocyte" EXACT []
synonym: "centrocyte" RELATED [PMID:17992590]
is_a: CL:0000844 {is_inferred="true"} ! germinal center B cell
intersection_of: CL:0000844 ! germinal center B cell
intersection_of: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex
intersection_of: CL:4030046 PR:000003516 ! lacks_plasma_membrane_part lactosylceramide 4-alpha-galactosyltransferase
intersection_of: in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: output_of GO:0016446 ! somatic hypermutation of immunoglobulin genes
intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
relationship: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex
relationship: CL:4030046 PR:000003516 ! lacks_plasma_membrane_part lactosylceramide 4-alpha-galactosyltransferase
relationship: develops_from CL:0000963 ! Bm3-delta B cell
relationship: in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: output_of GO:0016446 ! somatic hypermutation of immunoglobulin genes
relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
[Term]
id: CL:0000967
name: Bm5 B cell
def: "A memory B cell arising in the germinal center that is IgD-negative and has undergone somatic mutation of the variable region of the immunoglobulin heavy and light chain genes." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMID:11564773, PMID:18432934, PMID:19350211, PMID:31681331, PMID:8006591]
comment: Bm5 B cells are also reportedly CD10-positive, CD23-negative, CD38-negative, CD39-positive, CD44-positive, CD71-positive, and CD77-negative.
synonym: "Bm5 B lymphocyte" EXACT []
synonym: "Bm5 B-cell" EXACT []
synonym: "Bm5 B-lymphocyte" EXACT []
is_a: CL:0001053 ! IgD-negative memory B cell
intersection_of: CL:0000787 ! memory B cell
intersection_of: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex
intersection_of: in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: output_of GO:0002314 ! germinal center B cell differentiation
intersection_of: output_of GO:0016446 ! somatic hypermutation of immunoglobulin genes
relationship: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex
relationship: develops_from CL:0000966 ! Bm4 B cell
relationship: in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: output_of GO:0002314 ! germinal center B cell differentiation
relationship: output_of GO:0016446 ! somatic hypermutation of immunoglobulin genes
[Term]
id: CL:0000970
name: unswitched memory B cell
def: "An unswitched memory B cell is a memory B cell that has the phenotype IgM-positive, IgD-positive, CD27-positive, CD138-negative, IgG-negative, IgE-negative, and IgA-negative." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:rhs, ISBN:0781765196, PMID:20933013, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'IgD+ memory B cell'. Per DSD: Unswitched memory B cells are also reportedly CD48-positive, CD84-positive, CD229-positive, and CD352-positive.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "IgD+ memory B cell" BROAD [PMID:22343568]
synonym: "non-class-switched memory B cell" EXACT [HP:0032126]
synonym: "unswitched memory B lymphocyte" EXACT []
synonym: "unswitched memory B-cell" EXACT []
synonym: "unswitched memory B-lymphocyte" EXACT []
is_a: CL:0000787 {is_inferred="true"} ! memory B cell
intersection_of: CL:0000787 ! memory B cell
intersection_of: CL:4030046 GO:0071735 ! lacks_plasma_membrane_part IgG immunoglobulin complex
intersection_of: CL:4030046 GO:0071742 ! lacks_plasma_membrane_part IgE immunoglobulin complex
intersection_of: CL:4030046 GO:0071745 ! lacks_plasma_membrane_part IgA immunoglobulin complex
intersection_of: CL:4030046 PR:000001935 ! lacks_plasma_membrane_part syndecan-1
intersection_of: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex
intersection_of: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex
intersection_of: RO:0002104 PR:000001963 ! has plasma membrane part CD27 molecule
relationship: CL:4030046 GO:0071735 ! lacks_plasma_membrane_part IgG immunoglobulin complex
relationship: CL:4030046 GO:0071742 ! lacks_plasma_membrane_part IgE immunoglobulin complex
relationship: CL:4030046 GO:0071745 ! lacks_plasma_membrane_part IgA immunoglobulin complex
relationship: CL:4030046 PR:000001935 ! lacks_plasma_membrane_part syndecan-1
relationship: develops_from CL:0000980 ! plasmablast
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex
relationship: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex
relationship: RO:0002104 PR:000001963 ! has plasma membrane part CD27 molecule
[Term]
id: CL:0000971
name: IgM memory B cell
def: "An IgM memory B cell is an unswitched memory B cell with the phenotype IgM-positive and IgD-negative." [GO_REF:0000031, GOC:dsd, GOC:rhs, ISBN:0781765196, PMID:19447676]
comment: IgM memory B cells are also reportedly CD1c-positive, CD95-positive, CD80-positive, CD84-positive, CD86-positive, CD150-negative, CD229-positive, CD289-positive, and CD290-positive. Transcription factors: Notch2-positive, PAX5-positive, SpiB-positive, Ets1-positive, and OBF1-positive.
synonym: "IgM memory B lymphocyte" EXACT []
synonym: "IgM memory B-cell" EXACT []
synonym: "IgM memory B-lymphocyte" EXACT []
synonym: "memory IgM B cell" EXACT []
synonym: "memory IgM B lymphocyte" EXACT []
synonym: "memory IgM B-cell" EXACT []
synonym: "memory IgM B-lymphocyte" EXACT []
is_a: CL:0001053 ! IgD-negative memory B cell
intersection_of: CL:0000787 ! memory B cell
intersection_of: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex
intersection_of: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex
relationship: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex
relationship: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex
[Term]
id: CL:0000972
name: class switched memory B cell
def: "A class switched memory B cell is a memory B cell that has undergone Ig class switching and therefore is IgM-negative on the cell surface. These cells are CD27-positive and have either IgG, IgE, or IgA on the cell surface." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:rhs, ISBN:0781765196, PMID:20933013, PMID:9295047]
comment: Per DSD: Class switched memory B cells are also reportedly CD48-positive, CD229-positive, and CD352-positive.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "class switched memory B lymphocyte" EXACT []
synonym: "class switched memory B-cell" EXACT []
synonym: "class switched memory B-lymphocyte" EXACT []
is_a: CL:0000787 {is_inferred="true"} ! memory B cell
intersection_of: CL:0000787 ! memory B cell
intersection_of: CL:4030046 GO:0071753 ! lacks_plasma_membrane_part IgM immunoglobulin complex
intersection_of: output_of GO:0045190 ! isotype switching
intersection_of: RO:0002104 PR:000001963 ! has plasma membrane part CD27 molecule
relationship: CL:4030046 GO:0071753 ! lacks_plasma_membrane_part IgM immunoglobulin complex
relationship: develops_from CL:0000970 ! unswitched memory B cell
relationship: output_of GO:0045190 ! isotype switching
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 PR:000001963 ! has plasma membrane part CD27 molecule
[Term]
id: CL:0000973
name: IgA memory B cell
def: "A class switched memory B cell that expresses IgA." [GO_REF:0000031, GOC:dsd, GOC:msz, ISBN:0781765196]
comment: IgA memory B cell are also reportedly RORalpha-positive.
synonym: "IgA memory B lymphocyte" EXACT []
synonym: "IgA memory B-cell" EXACT []
synonym: "IgA memory B-lymphocyte" EXACT []
synonym: "memory IgA B cell" EXACT []
synonym: "memory IgA B lymphocyte" EXACT []
synonym: "memory IgA B-cell" EXACT []
synonym: "memory IgA B-lymphocyte" EXACT []
is_a: CL:4052108 ! IgD-negative class switched memory B cell
intersection_of: CL:0000972 ! class switched memory B cell
intersection_of: RO:0002104 GO:0071745 ! has plasma membrane part IgA immunoglobulin complex
relationship: RO:0002104 GO:0071745 ! has plasma membrane part IgA immunoglobulin complex
[Term]
id: CL:0000979
name: IgG memory B cell
def: "An IgG memory B cell is a class switched memory B cell that is class switched and expresses IgG on the cell surface." [GO_REF:0000031, GOC:rhs, ISBN:0781765196]
subset: cellxgene_subset
synonym: "IgG memory B lymphocyte" EXACT []
synonym: "IgG memory B-cell" EXACT []
synonym: "IgG memory B-lymphocyte" EXACT []
synonym: "memory IgG B cell" EXACT []
synonym: "memory IgG B lymphocyte" EXACT []
synonym: "memory IgG B-cell" EXACT []
synonym: "memory IgG B-lymphocyte" EXACT []
is_a: CL:0000972 {is_inferred="true"} ! class switched memory B cell
intersection_of: CL:0000972 ! class switched memory B cell
intersection_of: RO:0002104 GO:0071735 ! has plasma membrane part IgG immunoglobulin complex
relationship: RO:0002104 GO:0071735 ! has plasma membrane part IgG immunoglobulin complex
[Term]
id: CL:0000980
name: plasmablast
def: "An activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMCID:PMC2673126]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'plasmablast'. Plasmablasts are also reportedly CD48-positive, CD63-positive, CD229-positive, CD270-positive, CD319-positive, CD352-positive, CD361-positive, and IgD-negative.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "CD20-negative B cell" BROAD []
synonym: "CD27-positive, CD38-positive, CD20-negative B cell" EXACT []
xref: FMA:84371
is_a: CL:0000785 {is_inferred="true"} ! mature B cell
is_a: CL:0000946 ! antibody secreting cell
intersection_of: CL:0000785 ! mature B cell
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: CL:4030046 PR:000001935 ! lacks_plasma_membrane_part syndecan-1
intersection_of: produces GO:0042571 ! immunoglobulin complex, circulating
intersection_of: RO:0015015 PR:000001408 ! has high plasma membrane amount ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
intersection_of: RO:0015015 PR:000001963 ! has high plasma membrane amount CD27 molecule
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001935 ! lacks_plasma_membrane_part syndecan-1
relationship: develops_from CL:0000785 ! mature B cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: produces GO:0042571 ! immunoglobulin complex, circulating
relationship: RO:0015015 PR:000001408 ! has high plasma membrane amount ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
relationship: RO:0015015 PR:000001963 ! has high plasma membrane amount CD27 molecule
[Term]
id: CL:0000981
name: double negative memory B cell
def: "A memory B cell with the phenotype IgD-negative and CD27-negative." [GO_REF:0000031, GOC:msz, GOC:tfm]
synonym: "dn memory B cell" EXACT []
synonym: "dn memory B lymphocyte" EXACT []
synonym: "dn memory B-cell" EXACT []
synonym: "dn memory B-lymphocyte" EXACT []
synonym: "double negative memory B lymphocyte" EXACT []
synonym: "double negative memory B-cell" EXACT []
synonym: "double negative memory B-lymphocyte" EXACT []
is_a: CL:0001053 ! IgD-negative memory B cell
intersection_of: CL:0000787 ! memory B cell
intersection_of: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex
intersection_of: CL:4030046 PR:000001963 ! lacks_plasma_membrane_part CD27 molecule
relationship: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex
relationship: CL:4030046 PR:000001963 ! lacks_plasma_membrane_part CD27 molecule
[Term]
id: CL:0000988
name: hematopoietic cell
def: "A cell of a hematopoietic lineage." [GO_REF:0000031, GOC:add]
subset: cellxgene_subset
subset: general_cell_types_upper_slim
synonym: "haematopoietic cell" EXACT []
synonym: "haemopoietic cell" EXACT []
synonym: "hemopoietic cell" EXACT []
xref: BTO:0000574
xref: CALOHA:TS-2017
xref: FMA:70366
xref: FMA:83598
xref: ZFA:0005830 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000000 ! cell
[Term]
id: CL:0000990
name: conventional dendritic cell
def: "Conventional dendritic cell is a dendritic cell that is CD11c-high." [GO_REF:0000031, GOC:amm, PMID:17850486]
comment: Originally described in the dendritic cell ontology (DC_CL:0000003)(PMID:19243617) These cells are also CD20-negative, MHCII-positive.
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "cDC" EXACT []
synonym: "DC1" EXACT []
synonym: "dendritic reticular cell" EXACT []
synonym: "interdigitating cell" BROAD []
synonym: "type 1 DC" EXACT []
synonym: "veiled cell" BROAD []
xref: FMA:84191
is_a: CL:0000451 {is_inferred="true"} ! dendritic cell
intersection_of: CL:0000451 ! dendritic cell
intersection_of: RO:0015015 PR:000001013 ! has high plasma membrane amount integrin alpha-X
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0015015 PR:000001013 ! has high plasma membrane amount integrin alpha-X
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000990" xsd:string {name="conventional dendritic cell on CELLxGENE CellGuide"}
[Term]
id: CL:0000995
name: CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor
comment: Originally described in the dendritic cell ontology (DC_CL:1100000)(PMID:19243617).
synonym: "CD71-positive common myeloid precursor OR CD7-negative lymphoid precursor OR CD7-positive lymphoid" BROAD []
is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative
is_a: CL:0011026 ! progenitor cell
union_of: CL:0001021 ! CD34-positive, CD38-positive common lymphoid progenitor
union_of: CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor
[Term]
id: CL:0001008
name: Kit and Sca1-positive hematopoietic stem cell
def: "A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMID:17952047, PMID:19022770]
comment: Cell markers are associated with mouse hematopoietic stem cell. Originally described in the dendritic cell ontology (DC_CL:0000043)(PMID:19243617).
synonym: "LSK stem cell" EXACT []
synonym: "Sca1-positive hematopoietic stem cell" EXACT []
is_a: CL:0000037 {is_inferred="true"} ! hematopoietic stem cell
intersection_of: CL:0000037 ! hematopoietic stem cell
intersection_of: CL:4030046 PR:000001014 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: CL:4030046 PR:000001308 ! lacks_plasma_membrane_part CD48 molecule
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha
intersection_of: CL:4030046 PR:000001896 ! lacks_plasma_membrane_part natural killer cell receptor 2B4
intersection_of: CL:4030046 PR:000002977 ! lacks_plasma_membrane_part killer cell lectin-like receptor subfamily B member 1C
intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
intersection_of: RO:0002104 PR:000001833 ! has plasma membrane part SLAM family member 1
intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor
intersection_of: RO:0002104 PR:000002979 ! has plasma membrane part lymphocyte antigen 6A-2/6E-1
disjoint_from: CL:0001024 ! CD34-positive, CD38-negative hematopoietic stem cell
relationship: CL:4030046 PR:000001014 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001308 ! lacks_plasma_membrane_part CD48 molecule
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha
relationship: CL:4030046 PR:000001896 ! lacks_plasma_membrane_part natural killer cell receptor 2B4
relationship: CL:4030046 PR:000002977 ! lacks_plasma_membrane_part killer cell lectin-like receptor subfamily B member 1C
relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
relationship: RO:0002104 PR:000001833 ! has plasma membrane part SLAM family member 1
relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor
relationship: RO:0002104 PR:000002979 ! has plasma membrane part lymphocyte antigen 6A-2/6E-1
[Term]
id: CL:0001012
name: CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
comment: Originally described in the dendritic cell ontology (DC_CL:1110000)(PMID:19243617).
is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative
is_a: CL:0011026 ! progenitor cell
union_of: CL:0000557 ! granulocyte monocyte progenitor cell
union_of: CL:0001027 ! CD7-negative lymphoid progenitor cell
[Term]
id: CL:0001019
name: CD115-positive monocyte OR common dendritic progenitor
comment: Originally described in the dendritic cell ontology (DC_CL:1111000)(PMID:19243617).
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell
union_of: CL:0001022 ! CD115-positive monocyte
union_of: CL:0001029 ! common dendritic progenitor
[Term]
id: CL:0001021
name: CD34-positive, CD38-positive common lymphoid progenitor
def: "A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMCID:PMC2346585, PMID:19022770]
comment: These markers are associated with human common lymphoid progenitors. Originally described in the dendritic cell ontology (DC_CL:0000032)(PMID:19243617).
synonym: "CD10-positive common lymphocyte precursor" EXACT []
synonym: "CD10-positive common lymphocyte progenitor" EXACT []
synonym: "CD10-positive common lymphoid precursor" EXACT []
is_a: CL:0000051 {is_inferred="true"} ! common lymphoid progenitor
is_a: CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor
intersection_of: CL:0000051 ! common lymphoid progenitor
intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
intersection_of: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
intersection_of: RO:0002104 PR:000001898 ! has plasma membrane part neprilysin
disjoint_from: CL:0001025 ! Kit-positive, Sca1-positive common lymphoid progenitor
relationship: develops_from CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell
relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
relationship: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
relationship: RO:0002104 PR:000001898 ! has plasma membrane part neprilysin
[Term]
id: CL:0001022
name: CD115-positive monocyte
def: "CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive." [GO_REF:0000031, GOC:add, GOC:amm, PMID:17952047]
comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000033)(PMID:19243617).
is_a: CL:0000576 {is_inferred="true"} ! monocyte
is_a: CL:0000839 ! myeloid lineage restricted progenitor cell
is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor
intersection_of: CL:0000576 ! monocyte
intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
intersection_of: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor
relationship: develops_from CL:0002001 ! CD34-positive, CD38-positive granulocyte monocyte progenitor
relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
relationship: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor
[Term]
id: CL:0001023
name: Kit-positive, CD34-positive common myeloid progenitor
def: "A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, http://www.immgen.org/index_content.html, PMID:1261582, PMID:17952047]
comment: Markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000034)(PMID:19243617).
synonym: "CD117-positive common myeloid precursor" BROAD []
is_a: CL:0001030 ! CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor
is_a: CL:0001059 {is_inferred="true"} ! common myeloid progenitor, CD34-positive
intersection_of: CL:0001059 ! common myeloid progenitor, CD34-positive
intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha
intersection_of: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1
intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor
intersection_of: RO:0015016 GO:0033001 ! has low plasma membrane amount Fc-gamma receptor III complex
intersection_of: RO:0015016 PR:000001481 ! has low plasma membrane amount low affinity immunoglobulin gamma Fc region receptor II-b
disjoint_from: CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor
relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha
relationship: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1
relationship: develops_from CL:0002035 ! Slamf1-negative multipotent progenitor cell
relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor
relationship: RO:0015016 GO:0033001 ! has low plasma membrane amount Fc-gamma receptor III complex
relationship: RO:0015016 PR:000001481 ! has low plasma membrane amount low affinity immunoglobulin gamma Fc region receptor II-b
[Term]
id: CL:0001024
name: CD34-positive, CD38-negative hematopoietic stem cell
def: "CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMID:10430905, PMID:11750107, PMID:16551251, PMID:20024907, PMID:9389721]
comment: Cell markers are associated with human hematopoietic stem cells. Originally described in the dendritic cell ontology (DC_CL:0000035)(PMID:19243617).
subset: cellxgene_subset
synonym: "CD133-positive hematopoietic stem cell" EXACT [PMID:16140871]
xref: CALOHA:TS-0448
is_a: CL:0000037 {is_inferred="true"} ! hematopoietic stem cell
intersection_of: CL:0000037 ! hematopoietic stem cell
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
intersection_of: CL:4030046 PR:000001483 ! lacks_plasma_membrane_part low affinity immunoglobulin gamma Fc region receptor III
intersection_of: CL:4030046 PR:000001892 ! lacks_plasma_membrane_part CD33 molecule
intersection_of: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part transferrin receptor protein 1
intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
intersection_of: RO:0002104 PR:000001786 ! has plasma membrane part prominin-1
intersection_of: RO:0002104 PR:000001809 ! has plasma membrane part CD59-like glycoprotein
intersection_of: RO:0002104 PR:000001843 ! has plasma membrane part Thy-1 membrane glycoprotein
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
relationship: CL:4030046 PR:000001483 ! lacks_plasma_membrane_part low affinity immunoglobulin gamma Fc region receptor III
relationship: CL:4030046 PR:000001892 ! lacks_plasma_membrane_part CD33 molecule
relationship: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part transferrin receptor protein 1
relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
relationship: RO:0002104 PR:000001786 ! has plasma membrane part prominin-1
relationship: RO:0002104 PR:000001809 ! has plasma membrane part CD59-like glycoprotein
relationship: RO:0002104 PR:000001843 ! has plasma membrane part Thy-1 membrane glycoprotein
[Term]
id: CL:0001025
name: Kit-positive, Sca1-positive common lymphoid progenitor
def: "A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, http://www.immgen.org/index_content.html, PMID:17952047]
comment: Markers are associated with mouse cells.
synonym: "CD217-positive common lymphocyte precursor" EXACT []
synonym: "CD217-positive common lymphocyte progenitor" EXACT []
synonym: "CD217-positive common lymphoid precursor" EXACT []
is_a: CL:0000051 {is_inferred="true"} ! common lymphoid progenitor
is_a: CL:0001030 ! CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor
intersection_of: CL:0000051 ! common lymphoid progenitor
intersection_of: CL:4030046 PR:000001014 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
intersection_of: RO:0002104 PR:000001869 ! has plasma membrane part interleukin-7 receptor subunit alpha
intersection_of: RO:0002104 PR:000001963 ! has plasma membrane part CD27 molecule
intersection_of: RO:0002104 PR:000002001 ! has plasma membrane part receptor-type tyrosine-protein kinase FLT3
intersection_of: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor
intersection_of: RO:0015016 PR:000002065 ! has low plasma membrane amount mast/stem cell growth factor receptor
intersection_of: RO:0015016 PR:000002979 ! has low plasma membrane amount lymphocyte antigen 6A-2/6E-1
relationship: CL:4030046 PR:000001014 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
relationship: develops_from CL:0000936 ! early lymphoid progenitor
relationship: RO:0002104 PR:000001869 ! has plasma membrane part interleukin-7 receptor subunit alpha
relationship: RO:0002104 PR:000001963 ! has plasma membrane part CD27 molecule
relationship: RO:0002104 PR:000002001 ! has plasma membrane part receptor-type tyrosine-protein kinase FLT3
relationship: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor
relationship: RO:0015016 PR:000002065 ! has low plasma membrane amount mast/stem cell growth factor receptor
relationship: RO:0015016 PR:000002979 ! has low plasma membrane amount lymphocyte antigen 6A-2/6E-1
[Term]
id: CL:0001026
name: CD34-positive, CD38-positive common myeloid progenitor
def: "A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative." [GO_REF:0000031, GOC:add, GOC:amm, PMCID:PMC2626675, PMID:16551251]
comment: Markers are associated with human cell type. Originally described in the dendritic cell ontology (DC_CL:0000038)(PMID:19243617).
synonym: "CD71-positive common myeloid precursor" NARROW []
is_a: CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor
is_a: CL:0001059 ! common myeloid progenitor, CD34-positive
intersection_of: CL:0001059 ! common myeloid progenitor, CD34-positive
intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: CL:4030046 PR:000001836 ! lacks_plasma_membrane_part CD7 molecule
intersection_of: CL:4030046 PR:000001867 ! lacks_plasma_membrane_part interleukin-5 receptor subunit alpha
intersection_of: CL:4030046 PR:000001898 ! lacks_plasma_membrane_part neprilysin
intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
intersection_of: RO:0015016 PR:000001865 ! has low plasma membrane amount interleukin-3 receptor class 2 alpha chain
relationship: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: CL:4030046 PR:000001836 ! lacks_plasma_membrane_part CD7 molecule
relationship: CL:4030046 PR:000001867 ! lacks_plasma_membrane_part interleukin-5 receptor subunit alpha
relationship: CL:4030046 PR:000001898 ! lacks_plasma_membrane_part neprilysin
relationship: develops_from CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell
relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
relationship: RO:0015016 PR:000001865 ! has low plasma membrane amount interleukin-3 receptor class 2 alpha chain
[Term]
id: CL:0001027
name: CD7-negative lymphoid progenitor cell
def: "CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative." [GO_REF:0000031, GOC:amm, PMID:16551251]
comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000039)(PMID:19243617).
synonym: "CD7-negative lymphoid precursor" EXACT []
is_a: CL:0000051 {is_inferred="true"} ! common lymphoid progenitor
is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
intersection_of: CL:0000051 ! common lymphoid progenitor
intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: CL:4030046 PR:000001836 ! lacks_plasma_membrane_part CD7 molecule
intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
relationship: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: CL:4030046 PR:000001836 ! lacks_plasma_membrane_part CD7 molecule
relationship: develops_from CL:0001021 ! CD34-positive, CD38-positive common lymphoid progenitor
relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
[Term]
id: CL:0001028
name: CD7-positive lymphoid progenitor cell
def: "CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:16551251, PMID:19491395]
comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000040)(PMID:19243617).
synonym: "CD7-positive lymphoid precursor" EXACT []
is_a: CL:0000051 {is_inferred="true"} ! common lymphoid progenitor
intersection_of: CL:0000051 ! common lymphoid progenitor
intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
intersection_of: RO:0002104 PR:000001836 ! has plasma membrane part CD7 molecule
relationship: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: develops_from CL:0001027 ! CD7-negative lymphoid progenitor cell
relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
relationship: RO:0002104 PR:000001836 ! has plasma membrane part CD7 molecule
[Term]
id: CL:0001029
name: common dendritic progenitor
def: "Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:16551251, PMID:17922016, PMID:19286519]
comment: Surface markers are for mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000041) CDP are reportedly CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD11c-positive, CD14-negative, CD19-negative, CD20-negative, CD56-negative, B220-negative, Ly6g-negative, MHCII-positive, and Ter119-negative. (PMID:19243617).
subset: cellxgene_subset
synonym: "CDP" EXACT [PMID:21219184]
synonym: "common dendritic precursor" EXACT []
synonym: "pro-DCs" EXACT [PMID:21219184]
is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor
intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
intersection_of: RO:0002104 PR:000002001 ! has plasma membrane part receptor-type tyrosine-protein kinase FLT3
intersection_of: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor
intersection_of: RO:0015016 PR:000002065 ! has low plasma membrane amount mast/stem cell growth factor receptor
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
relationship: develops_from CL:0002009 ! macrophage dendritic cell progenitor
relationship: RO:0002104 PR:000002001 ! has plasma membrane part receptor-type tyrosine-protein kinase FLT3
relationship: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor
relationship: RO:0015016 PR:000002065 ! has low plasma membrane amount mast/stem cell growth factor receptor
[Term]
id: CL:0001030
name: CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor
comment: Originally described in the dendritic cell ontology (DC_CL:1111100)(PMID:19243617).
is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative
is_a: CL:0011026 ! progenitor cell
union_of: CL:0001023 ! Kit-positive, CD34-positive common myeloid progenitor
union_of: CL:0001025 ! Kit-positive, Sca1-positive common lymphoid progenitor
[Term]
id: CL:0001031
name: cerebellar granule cell
def: "An excitatory granule cell with a soma located in the granular layer of cerebellar cortex. A mature cerebellar granule cell has short dendrites with a characteristic claw-like appearance and a long axon that ascends to the molecular layer where it bifurcates (except in non-teleost fish, where it does not bifurcate) and extends mediolaterally to form parallel fibers." [doi:10.12688/f1000research.15021.1, doi:10.3389/fncir.2020.611841, GOC:mah]
comment: It has been noted in at least some mammalian species that granule cells are the most numerous cell type in the cerebellum and in the brain, with at least 99% of all cerebellar neurons being granule cells. {xref="doi:10.3389/fncir.2020.611841"}
subset: cellxgene_subset
synonym: "granule cell of the cerebellum" EXACT [doi:10.3389/fncir.2020.611841]
xref: BTO:0004278
xref: ZFA:0001691 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000120 ! granule cell
is_a: CL:2000028 ! cerebellum glutamatergic neuron
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: CL:0000120 ! granule cell
intersection_of: RO:0002100 UBERON:0002037 ! has soma location cerebellum
relationship: develops_from CL:0002362 ! cerebellar granule cell precursor
relationship: develops_from NCBITaxon:6072 ! Eumetazoa
relationship: develops_from UBERON:0000955 ! brain
relationship: develops_from UBERON:0001016 ! nervous system
relationship: develops_from UBERON:0001017 ! central nervous system
relationship: develops_from UBERON:0001049 ! neural tube
relationship: develops_from UBERON:0002028 ! hindbrain
relationship: develops_from UBERON:0005499 ! rhombomere 1
relationship: develops_from UBERON:0006215 ! rhombic lip
relationship: develops_from UBERON:0009841 ! upper rhombic lip
relationship: develops_from UBERON:0010092 ! future metencephalon
relationship: directly_develops_from CL:0002362 ! cerebellar granule cell precursor
relationship: RO:0002100 UBERON:0002037 ! has soma location cerebellum
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0001031" xsd:string {name="cerebellar granule cell on CELLxGENE CellGuide"}
[Term]
id: CL:0001032
name: cortical granule cell
def: "Granule cell that is part of the cerebral cortex." [GOC:mah]
is_a: CL:0000120 ! granule cell
is_a: CL:0010012 ! cerebral cortex neuron
intersection_of: CL:0000120 ! granule cell
intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
relationship: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
[Term]
id: CL:0001033
name: hippocampal granule cell
def: "Granule cell with a soma found in the hippocampus." [GOC:mah]
subset: cellxgene_subset
is_a: CL:0001032 ! cortical granule cell
is_a: CL:0002608 ! hippocampal neuron
intersection_of: CL:0000120 ! granule cell
intersection_of: RO:0002100 UBERON:0002421 ! has soma location hippocampal formation
relationship: RO:0002100 UBERON:0002421 ! has soma location hippocampal formation
[Term]
id: CL:0001035
name: bone cell
def: "A connective tissue cell found in bone." [GO_REF:0000034, GOC:add]
subset: general_cell_types_upper_slim
subset: human_reference_atlas
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0001474 ! bone element
relationship: dc-contributor https://orcid.org/0000-0001-9990-8331
relationship: part_of UBERON:0001474 ! bone element
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0001035" xsd:string {name="bone cell on CELLxGENE CellGuide"}
creation_date: 2011-11-16T04:28:16Z
[Term]
id: CL:0001039
name: terminally differentiated osteoblast
def: "Osteoblast that is terminally differentiated, located adjacent to acellular or cellular bone tissue within periosteum, and is capable of mineralizing the matrix." [VSAO:curator]
xref: VSAO:0000116
is_a: CL:0000062 ! osteoblast
[Term]
id: CL:0001040
name: non-terminally differentiated osteoblast
def: "Osteoblast that is non-terminally differentiated and located in cellular bone tissue or under the periosteum in acellular bone." [VSAO:curator]
comment: VSAO relationship simplified OBO_REL:integral_part_of VSAO:0000118
xref: VSAO:0000117
is_a: CL:0000062 ! osteoblast
is_a: CL:0001035 ! bone cell
is_a: CL:0011026 ! progenitor cell
relationship: part_of UBERON:0002481 ! bone tissue
[Term]
id: CL:0001053
name: IgD-negative memory B cell
def: "A memory B cell that lacks expression of surface IgD." [GOC:add, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'IgD- memory B cell'. The majority of these cells are class-switched, though some are IgM-positive.
synonym: "IgD- memory B cell" EXACT [PMID:22343568]
is_a: CL:0000787 ! memory B cell
intersection_of: CL:0000787 ! memory B cell
intersection_of: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex
relationship: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex
[Term]
id: CL:0001054
name: CD14-positive monocyte
def: "A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20." [GOC:add, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'monocyte'. Note that while CD14 is considered a reliable marker for human monocytes, it is only expressed on approximately 85% of mouse monocytes.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "monocyte" NARROW [PMID:22343568]
is_a: CL:0000576 ! monocyte
intersection_of: CL:0000576 ! monocyte
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: RO:0002104 PR:000001889 ! has plasma membrane part CD14 molecule
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 PR:000001889 ! has plasma membrane part CD14 molecule
[Term]
id: CL:0001055
name: CD14-positive, CD16-low monocyte
def: "An intermediate monocyte that is CD14-positive and with low amounts of CD16." [GOC:add, PMID:20628149]
comment: Definition is valid for human intermediate monocytes.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "intermediate monocyte, human" EXACT []
is_a: CL:0002393 ! intermediate monocyte
is_a: CL:0002397 ! CD14-positive, CD16-positive monocyte
intersection_of: CL:0002393 ! intermediate monocyte
intersection_of: RO:0002104 PR:000001889 ! has plasma membrane part CD14 molecule
intersection_of: RO:0015016 PR:000001483 ! has low plasma membrane amount low affinity immunoglobulin gamma Fc region receptor III
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 PR:000001889 ! has plasma membrane part CD14 molecule
relationship: RO:0015016 PR:000001483 ! has low plasma membrane amount low affinity immunoglobulin gamma Fc region receptor III
[Term]
id: CL:0001059
name: common myeloid progenitor, CD34-positive
def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0878932437, PMCID:PMC2212039, PMID:10724173, PMID:16551251, PMID:16647566]
comment: CMP are reportedly CD16-positive, CD32-positive, CD38-positive, CD45RA-negative, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative.
synonym: "CFU-GEMM" RELATED OMO:0003000 [ISBN:0878932437]
synonym: "CFU-S" RELATED OMO:0003000 [ISBN:0878932437]
synonym: "CMP" RELATED OMO:0003000 [ISBN:0878932437]
synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437]
synonym: "common myeloid precursor, CD34-positive" EXACT []
synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437]
synonym: "myeloid stem cell" RELATED [ISBN:0878932437]
synonym: "pluripotent stem cell (bone marrow)" RELATED [ISBN:0878932437]
is_a: CL:0000049 ! common myeloid progenitor
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0000049 ! common myeloid progenitor
intersection_of: capable_of GO:0002573 ! myeloid leukocyte differentiation
intersection_of: capable_of GO:0043011 ! myeloid dendritic cell differentiation
intersection_of: has_part PR:000001944 ! transcription factor PU.1
intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha
intersection_of: has_part PR:000007857 ! erythroid transcription factor
intersection_of: has_part PR:000007858 ! endothelial transcription factor GATA-2
intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
relationship: capable_of GO:0002573 ! myeloid leukocyte differentiation
relationship: capable_of GO:0043011 ! myeloid dendritic cell differentiation
relationship: has_part PR:000001944 ! transcription factor PU.1
relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha
relationship: has_part PR:000007857 ! erythroid transcription factor
relationship: has_part PR:000007858 ! endothelial transcription factor GATA-2
relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
[Term]
id: CL:0001060
name: hematopoietic oligopotent progenitor cell, lineage-negative
def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers." [GOC:tfm, PMID:19022770]
is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
intersection_of: RO:0000053 PATO:0001401 ! has characteristic oligopotent
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: RO:0000053 PATO:0001401 ! has characteristic oligopotent
creation_date: 2010-01-06T03:43:27Z
[Term]
id: CL:0001065
name: innate lymphoid cell
def: "A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses." [GOC:add, GOC:dsd, PMID:23292121, PMID:23348417]
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:0000542 ! lymphocyte
intersection_of: CL:0000542 ! lymphocyte
intersection_of: capable_of GO:0001816 ! cytokine production
intersection_of: capable_of GO:0045087 ! innate immune response
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: capable_of GO:0001816 ! cytokine production
relationship: capable_of GO:0045087 ! innate immune response
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: dc-contributor https://orcid.org/0000-0001-9990-8331
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2017-01-30T20:20:48Z" xsd:dateTime
[Term]
id: CL:0001066
name: erythroid progenitor cell, mammalian
def: "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative)." [GOC:add, ISBN:0721601464]
subset: cellxgene_subset
synonym: "BFU-E" RELATED OMO:0003000 []
synonym: "blast forming unit erythroid" RELATED []
synonym: "burst forming unit erythroid" RELATED []
synonym: "CFU-E" RELATED OMO:0003000 []
synonym: "colony forming unit erythroid" RELATED []
synonym: "erythroid stem cell" RELATED []
xref: BTO:0004911
is_a: CL:0000038 ! erythroid progenitor cell
intersection_of: CL:0000038 ! erythroid progenitor cell
intersection_of: capable_of GO:0030218 ! erythrocyte differentiation
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
intersection_of: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1
relationship: capable_of GO:0030218 ! erythrocyte differentiation
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
relationship: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0001066" xsd:string {name="erythroid progenitor cell, mammalian on CELLxGENE CellGuide"}
[Term]
id: CL:0001067
name: group 1 innate lymphoid cell
def: "An innate lymphoid cell that is capable of producing the type 1 cytokine IFN-gamma, but not Th2 or Th17 cell-associated cytokines." [GOC:add, GOC:dsd, PMID:23348417]
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:0001065 ! innate lymphoid cell
intersection_of: CL:0001065 ! innate lymphoid cell
intersection_of: capable_of GO:0032609 ! type II interferon production
relationship: capable_of GO:0032609 ! type II interferon production
relationship: dc-contributor https://orcid.org/0000-0001-9990-8331
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2017-01-30T20:42:44Z" xsd:dateTime
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0001067" xsd:string {name="group 1 innate lymphoid cell on CELLxGENE CellGuide"}
[Term]
id: CL:0001072
name: CD34-negative, CD117-positive innate lymphoid cell, human
def: "An innate lymphoid cell in the human with the phenotype CD34-negative, CD117-positive, and a precusor to NK cells, ILC2 cells, and ILC3 cells." [GOC:add, PMID:30193847, PMID:31201208]
subset: cellxgene_subset
synonym: "CD34-negative, CD117-positive ILC" EXACT []
synonym: "CD34-negative, CD117-positive ILCP" EXACT []
synonym: "CD34-negative, CD117-positive innate lymphoid cell precusor" EXACT []
is_a: CL:0001082 ! immature innate lymphoid cell
intersection_of: CL:0001065 ! innate lymphoid cell
intersection_of: CL:4030046 PR:P28906 ! lacks_plasma_membrane_part hematopoietic progenitor cell antigen CD34 (human)
intersection_of: in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: RO:0000053 PATO:0001501 ! has characteristic immature
intersection_of: RO:0002104 PR:P10721 ! has plasma membrane part mast/stem cell growth factor receptor Kit (human)
relationship: CL:4030046 PR:P28906 ! lacks_plasma_membrane_part hematopoietic progenitor cell antigen CD34 (human)
relationship: develops_from CL:0001074 ! CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human
relationship: in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0000053 PATO:0001501 ! has characteristic immature
relationship: RO:0002104 PR:P10721 ! has plasma membrane part mast/stem cell growth factor receptor Kit (human)
[Term]
id: CL:0001073
name: CD34-negative, CD56-positive, CD117-positive innate lymphoid cell, human
def: "An innate lymphoid cell in the human with the phenotype CD34-negative, CD56-positive, CD117-positive.Thie cell type may include precusors to NK cells and ILC3 cells." [GOC:add, PMID:30193847, PMID:31201208]
synonym: "CD34-negative, CD56-positive, CD117-positive ILC" EXACT []
synonym: "CD34-negative, CD56-positive, CD117-positive ILCP" EXACT []
synonym: "CD34-negative, CD56-positive, CD117-positive innate lymphoid cell precursor" EXACT []
is_a: CL:0001072 ! CD34-negative, CD117-positive innate lymphoid cell, human
intersection_of: CL:0001072 ! CD34-negative, CD117-positive innate lymphoid cell, human
intersection_of: in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: RO:0002104 PR:P10721 ! has plasma membrane part mast/stem cell growth factor receptor Kit (human)
intersection_of: RO:0002104 PR:P13591 ! has plasma membrane part neural cell adhesion molecule 1 (human)
relationship: in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 PR:P10721 ! has plasma membrane part mast/stem cell growth factor receptor Kit (human)
relationship: RO:0002104 PR:P13591 ! has plasma membrane part neural cell adhesion molecule 1 (human)
[Term]
id: CL:0001074
name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human
def: "An innate lymphoid cell precursor in the human with the phenotype CD34-positive, CD56-positive, CD117-positive.Thie cell type may include precusors to NK cells and ILC3 cells." [GOC:add, PMID:30193847]
subset: cellxgene_subset
synonym: "CD34-positive, CD56-positive, CD117-positive CILP" EXACT []
is_a: CL:0001082 ! immature innate lymphoid cell
intersection_of: CL:0001065 ! innate lymphoid cell
intersection_of: in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: RO:0000053 PATO:0001501 ! has characteristic immature
intersection_of: RO:0002104 PR:P10721 ! has plasma membrane part mast/stem cell growth factor receptor Kit (human)
intersection_of: RO:0002104 PR:P13591 ! has plasma membrane part neural cell adhesion molecule 1 (human)
intersection_of: RO:0002104 PR:P28906 ! has plasma membrane part hematopoietic progenitor cell antigen CD34 (human)
relationship: in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0000053 PATO:0001501 ! has characteristic immature
relationship: RO:0002104 PR:P10721 ! has plasma membrane part mast/stem cell growth factor receptor Kit (human)
relationship: RO:0002104 PR:P13591 ! has plasma membrane part neural cell adhesion molecule 1 (human)
relationship: RO:0002104 PR:P28906 ! has plasma membrane part hematopoietic progenitor cell antigen CD34 (human)
[Term]
id: CL:0001082
name: immature innate lymphoid cell
def: "An innate lyphoid cell with an immature phenotype." [GOC:add]
subset: cellxgene_subset
synonym: "immature ILC" EXACT []
is_a: CL:0001065 ! innate lymphoid cell
intersection_of: CL:0001065 ! innate lymphoid cell
intersection_of: RO:0000053 PATO:0001501 ! has characteristic immature
relationship: RO:0000053 PATO:0001501 ! has characteristic immature
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0001082" xsd:string {name="immature innate lymphoid cell on CELLxGENE CellGuide"}
[Term]
id: CL:0001200
name: lymphocyte of B lineage, CD19-positive
def: "A lymphocyte of B lineage that is CD19-positive." [GOC:add]
comment: Types of B lineage lymphocytes include B cells and antibody secreting cells (plasmablasts and plasma cells). Lymphocytes of B cell lineage can be distinguished from those of T cell lineage by their lack of CD3e (as part of the T cell receptor complex).
is_a: CL:0000945 ! lymphocyte of B lineage
intersection_of: CL:0000945 ! lymphocyte of B lineage
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: in_taxon NCBITaxon:40674 ! Mammalia
intersection_of: RO:0002104 PR:000001002 ! has plasma membrane part CD19 molecule
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: dc-contributor https://orcid.org/0000-0001-9990-8331
relationship: in_taxon NCBITaxon:40674 ! Mammalia
relationship: RO:0002104 PR:000001002 ! has plasma membrane part CD19 molecule
[Term]
id: CL:0001201
name: B cell, CD19-positive
def: "A B cell that is CD19-positive." [GOC:add]
synonym: "B lymphocyte, CD19-positive" EXACT []
synonym: "B-cell, CD19-positive" EXACT []
synonym: "B-lymphocyte, CD19-positive" EXACT []
synonym: "CD19+ B cell" EXACT []
synonym: "CD19-positive B cell" EXACT []
is_a: CL:0000236 ! B cell
is_a: CL:0001200 ! lymphocyte of B lineage, CD19-positive
intersection_of: CL:0001200 ! lymphocyte of B lineage, CD19-positive
intersection_of: capable_of GO:0019724 ! B cell mediated immunity
intersection_of: RO:0002104 PR:000001002 ! has plasma membrane part CD19 molecule
relationship: capable_of GO:0019724 ! B cell mediated immunity
relationship: dc-contributor https://orcid.org/0000-0001-9990-8331
relationship: RO:0002104 PR:000001002 ! has plasma membrane part CD19 molecule
[Term]
id: CL:0002000
name: Kit-positive erythroid progenitor cell
def: "An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative." [GOC:ak, GOC:tfm, http://www.immgen.org/index_content.html, PMID:19805084]
comment: Markers found on mouse cells.
synonym: "c- Kit-positive erythroid progenitor cell" EXACT []
is_a: CL:0001066 {is_inferred="true"} ! erythroid progenitor cell, mammalian
intersection_of: CL:0001066 ! erythroid progenitor cell, mammalian
intersection_of: CL:4030046 GO:0033001 ! lacks_plasma_membrane_part Fc-gamma receptor III complex
intersection_of: CL:4030046 PR:000001833 ! lacks_plasma_membrane_part SLAM family member 1
intersection_of: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleukin-3 receptor class 2 alpha chain
intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha
intersection_of: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1
intersection_of: CL:4030046 PR:000009127 ! lacks_plasma_membrane_part integrin alpha-IIb
intersection_of: RO:0002104 PR:000001345 ! has plasma membrane part endoglin
intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor
relationship: CL:4030046 GO:0033001 ! lacks_plasma_membrane_part Fc-gamma receptor III complex
relationship: CL:4030046 PR:000001833 ! lacks_plasma_membrane_part SLAM family member 1
relationship: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleukin-3 receptor class 2 alpha chain
relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha
relationship: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1
relationship: CL:4030046 PR:000009127 ! lacks_plasma_membrane_part integrin alpha-IIb
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002006 ! Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell
relationship: RO:0002104 PR:000001345 ! has plasma membrane part endoglin
relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor
creation_date: 2010-04-26T10:14:16Z
[Term]
id: CL:0002001
name: CD34-positive, CD38-positive granulocyte monocyte progenitor
def: "A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative." [GOC:tfm, PMID:12615892, PMID:19022770]
comment: Markers are for human cells. According to different research groups, CD45RA is present or absent on this cell population.
is_a: CL:0000557 {is_inferred="true"} ! granulocyte monocyte progenitor cell
intersection_of: CL:0000557 ! granulocyte monocyte progenitor cell
intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
intersection_of: RO:0002104 PR:000001865 ! has plasma membrane part interleukin-3 receptor class 2 alpha chain
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor
relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
relationship: RO:0002104 PR:000001865 ! has plasma membrane part interleukin-3 receptor class 2 alpha chain
creation_date: 2010-01-13T03:19:22Z
[Term]
id: CL:0002002
name: Kit-positive granulocyte monocyte progenitor
def: "A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:12615892, PMID:16322423, PMID:19022770, PMID:19273628]
comment: Markers are found on mouse cells.
is_a: CL:0000557 {is_inferred="true"} ! granulocyte monocyte progenitor cell
intersection_of: CL:0000557 ! granulocyte monocyte progenitor cell
intersection_of: CL:4030046 PR:000001206 ! lacks_plasma_membrane_part CX3C chemokine receptor 1
intersection_of: CL:4030046 PR:000001843 ! lacks_plasma_membrane_part Thy-1 membrane glycoprotein
intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha
intersection_of: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1
intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor
intersection_of: RO:0015015 GO:0033001 ! has high plasma membrane amount Fc-gamma receptor III complex
intersection_of: RO:0015015 PR:000001479 ! has high plasma membrane amount low affinity immunoglobulin gamma Fc region receptor II
relationship: CL:4030046 PR:000001206 ! lacks_plasma_membrane_part CX3C chemokine receptor 1
relationship: CL:4030046 PR:000001843 ! lacks_plasma_membrane_part Thy-1 membrane glycoprotein
relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha
relationship: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0001023 ! Kit-positive, CD34-positive common myeloid progenitor
relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor
relationship: RO:0015015 GO:0033001 ! has high plasma membrane amount Fc-gamma receptor III complex
relationship: RO:0015015 PR:000001479 ! has high plasma membrane amount low affinity immunoglobulin gamma Fc region receptor II
creation_date: 2010-01-13T03:19:28Z
[Term]
id: CL:0002003
name: CD34-positive, GlyA-negative erythroid progenitor cell
def: "An erythroid progenitor cell that is CD34-positive and is GlyA-negative." [GOC:ak, GOC:tfm, PMID:19621348]
comment: Cell markers associated with human cells.
xref: FMA:83517
is_a: CL:0001066 {is_inferred="true"} ! erythroid progenitor cell, mammalian
intersection_of: CL:0001066 ! erythroid progenitor cell, mammalian
intersection_of: CL:4030046 PR:000001460 ! lacks_plasma_membrane_part glycophorin-A
intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
relationship: CL:4030046 PR:000001460 ! lacks_plasma_membrane_part glycophorin-A
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002005 ! CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell
relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
creation_date: 2010-04-26T10:14:30Z
[Term]
id: CL:0002004
name: CD34-negative, GlyA-negative proerythroblast
def: "A proerythoblast that is CD34-negative and GlyA-negative." [GOC:ak, GOC:tfm, PMID:19621348]
comment: Cell surface markers are associated with human cells.
is_a: CL:0000547 {is_inferred="true"} ! proerythroblast
intersection_of: CL:0000547 ! proerythroblast
intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule
intersection_of: CL:4030046 PR:000001460 ! lacks_plasma_membrane_part glycophorin-A
relationship: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule
relationship: CL:4030046 PR:000001460 ! lacks_plasma_membrane_part glycophorin-A
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002003 ! CD34-positive, GlyA-negative erythroid progenitor cell
creation_date: 2010-04-26T10:31:50Z
[Term]
id: CL:0002005
name: CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell
def: "A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative." [GOC:tfm, PMID:12615892, PMID:190227700]
comment: Markers are associated with human cell type.
is_a: CL:0000050 {is_inferred="true"} ! megakaryocyte-erythroid progenitor cell
intersection_of: CL:0000050 ! megakaryocyte-erythroid progenitor cell
intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleukin-3 receptor class 2 alpha chain
intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
relationship: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleukin-3 receptor class 2 alpha chain
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
creation_date: 2010-01-13T03:43:10Z
[Term]
id: CL:0002006
name: Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell
def: "A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:12615892, PMID:19022770]
comment: Markers are associated with mouse cells.
is_a: CL:0000050 {is_inferred="true"} ! megakaryocyte-erythroid progenitor cell
intersection_of: CL:0000050 ! megakaryocyte-erythroid progenitor cell
intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule
intersection_of: CL:4030046 PR:000001479 ! lacks_plasma_membrane_part low affinity immunoglobulin gamma Fc region receptor II
intersection_of: CL:4030046 PR:000001843 ! lacks_plasma_membrane_part Thy-1 membrane glycoprotein
intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha
intersection_of: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1
intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor
intersection_of: RO:0015016 GO:0033001 ! has low plasma membrane amount Fc-gamma receptor III complex
relationship: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule
relationship: CL:4030046 PR:000001479 ! lacks_plasma_membrane_part low affinity immunoglobulin gamma Fc region receptor II
relationship: CL:4030046 PR:000001843 ! lacks_plasma_membrane_part Thy-1 membrane glycoprotein
relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha
relationship: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor
relationship: RO:0015016 GO:0033001 ! has low plasma membrane amount Fc-gamma receptor III complex
creation_date: 2010-01-13T03:43:12Z
[Term]
id: CL:0002009
name: macrophage dendritic cell progenitor
def: "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages." [GOC:tfm, PMID:19273628]
subset: cellxgene_subset
synonym: "MDP" EXACT []
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: capable_of GO:0030224 ! monocyte differentiation
intersection_of: capable_of GO:0043011 ! myeloid dendritic cell differentiation
relationship: capable_of GO:0030224 ! monocyte differentiation
relationship: capable_of GO:0043011 ! myeloid dendritic cell differentiation
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell
creation_date: 2010-01-19T02:51:58Z
[Term]
id: CL:0002011
name: Kit-positive macrophage dendritic cell progenitor
def: "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative." [GOC:tfm, PMID:19273628]
comment: Markers are associated with mouse cells.
synonym: "murine MDP" EXACT []
is_a: CL:0002009 {is_inferred="true"} ! macrophage dendritic cell progenitor
intersection_of: CL:0002009 ! macrophage dendritic cell progenitor
intersection_of: RO:0002104 PR:000001206 ! has plasma membrane part CX3C chemokine receptor 1
intersection_of: RO:0002104 PR:000002001 ! has plasma membrane part receptor-type tyrosine-protein kinase FLT3
intersection_of: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor
intersection_of: RO:0015015 PR:000002065 ! has high plasma membrane amount mast/stem cell growth factor receptor
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002002 ! Kit-positive granulocyte monocyte progenitor
relationship: RO:0002104 PR:000001206 ! has plasma membrane part CX3C chemokine receptor 1
relationship: RO:0002104 PR:000002001 ! has plasma membrane part receptor-type tyrosine-protein kinase FLT3
relationship: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor
relationship: RO:0015015 PR:000002065 ! has high plasma membrane amount mast/stem cell growth factor receptor
creation_date: 2010-01-26T02:43:40Z
[Term]
id: CL:0002012
name: Kit-low proerythroblast
def: "A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive." [GOC:ak, GOC:tfm, PMID:19805084]
comment: Markers are associated with mouse cells.
is_a: CL:0000547 {is_inferred="true"} ! proerythroblast
intersection_of: CL:0000547 ! proerythroblast
intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha
intersection_of: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1
intersection_of: RO:0002104 PR:000002981 ! has plasma membrane part lymphocyte antigen 76 (mouse)
intersection_of: RO:0015015 PR:000001945 ! has high plasma membrane amount transferrin receptor protein 1
intersection_of: RO:0015016 PR:000002065 ! has low plasma membrane amount mast/stem cell growth factor receptor
relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha
relationship: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002000 ! Kit-positive erythroid progenitor cell
relationship: RO:0002104 PR:000002981 ! has plasma membrane part lymphocyte antigen 76 (mouse)
relationship: RO:0015015 PR:000001945 ! has high plasma membrane amount transferrin receptor protein 1
relationship: RO:0015016 PR:000002065 ! has low plasma membrane amount mast/stem cell growth factor receptor
creation_date: 2010-04-26T10:31:56Z
[Term]
id: CL:0002013
name: GlyA-positive basophilic erythroblast
def: "A basophilic erythroblast that is GlyA-positive." [GOC:ak, GOC:tfm, PMID:1638021]
comment: Markers are associated with human cells.
is_a: CL:0000549 {is_inferred="true"} ! basophilic erythroblast
intersection_of: CL:0000549 ! basophilic erythroblast
intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule
intersection_of: RO:0002104 PR:000001460 ! has plasma membrane part glycophorin-A
relationship: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002004 ! CD34-negative, GlyA-negative proerythroblast
relationship: RO:0002104 PR:000001460 ! has plasma membrane part glycophorin-A
creation_date: 2010-04-26T10:41:15Z
[Term]
id: CL:0002014
name: Kit-negative, Ly-76 high basophilic erythroblast
def: "A basophilic erythroblast that is Lyg 76-high and is Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084]
comment: Cell surface markers are associated with mouse cells.
is_a: CL:0000549 {is_inferred="true"} ! basophilic erythroblast
intersection_of: CL:0000549 ! basophilic erythroblast
intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha
intersection_of: CL:4030046 PR:000002065 ! lacks_plasma_membrane_part mast/stem cell growth factor receptor
intersection_of: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1
intersection_of: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse)
relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha
relationship: CL:4030046 PR:000002065 ! lacks_plasma_membrane_part mast/stem cell growth factor receptor
relationship: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002012 ! Kit-low proerythroblast
relationship: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse)
creation_date: 2010-04-26T10:41:22Z
[Term]
id: CL:0002015
name: Kit-negative, Ly-76 high polychromatophilic erythroblast
def: "A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084]
synonym: "late basophilic and polychromatophilic erythroblast" BROAD []
is_a: CL:0000550 {is_inferred="true"} ! polychromatophilic erythroblast
intersection_of: CL:0000550 ! polychromatophilic erythroblast
intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha
intersection_of: CL:4030046 PR:000002065 ! lacks_plasma_membrane_part mast/stem cell growth factor receptor
intersection_of: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1
intersection_of: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse)
relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha
relationship: CL:4030046 PR:000002065 ! lacks_plasma_membrane_part mast/stem cell growth factor receptor
relationship: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002014 ! Kit-negative, Ly-76 high basophilic erythroblast
relationship: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse)
creation_date: 2010-04-26T10:53:11Z
[Term]
id: CL:0002016
name: CD71-low, GlyA-positive polychromatic erythroblast
def: "A polychromatiic erythroblast that is Gly-A-positive and CD71-low." [GOC:ak, GOC:tfm, PMID:1638021]
comment: Cell surface markers are associated with human cells.
is_a: CL:0000550 {is_inferred="true"} ! polychromatophilic erythroblast
intersection_of: CL:0000550 ! polychromatophilic erythroblast
intersection_of: RO:0002104 PR:000001460 ! has plasma membrane part glycophorin-A
intersection_of: RO:0015016 PR:000001945 ! has low plasma membrane amount transferrin receptor protein 1
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002013 ! GlyA-positive basophilic erythroblast
relationship: RO:0002104 PR:000001460 ! has plasma membrane part glycophorin-A
relationship: RO:0015016 PR:000001945 ! has low plasma membrane amount transferrin receptor protein 1
creation_date: 2010-04-26T10:53:16Z
[Term]
id: CL:0002017
name: Kit-negative, Ly-76 high orthochromatophilic erythroblasts
def: "An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084]
comment: Cell surface markers associated with mouse cells.
is_a: CL:0000552 {is_inferred="true"} ! orthochromatic erythroblast
intersection_of: CL:0000552 ! orthochromatic erythroblast
intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha
intersection_of: CL:4030046 PR:000002065 ! lacks_plasma_membrane_part mast/stem cell growth factor receptor
intersection_of: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1
intersection_of: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse)
intersection_of: RO:0015016 PR:000001945 ! has low plasma membrane amount transferrin receptor protein 1
relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha
relationship: CL:4030046 PR:000002065 ! lacks_plasma_membrane_part mast/stem cell growth factor receptor
relationship: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002015 ! Kit-negative, Ly-76 high polychromatophilic erythroblast
relationship: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse)
relationship: RO:0015016 PR:000001945 ! has low plasma membrane amount transferrin receptor protein 1
creation_date: 2010-04-26T11:04:15Z
[Term]
id: CL:0002018
name: CD71-negative, GlyA-positive orthochromatic erythroblast
def: "An erythroblast that is GlyA-positive and CD71-negative." [GOC:ak, GOC:tfm, PMID:1638021]
comment: Markers associated with human cells.
is_a: CL:0000552 {is_inferred="true"} ! orthochromatic erythroblast
intersection_of: CL:0000552 ! orthochromatic erythroblast
intersection_of: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part transferrin receptor protein 1
intersection_of: RO:0002104 PR:000001460 ! has plasma membrane part glycophorin-A
relationship: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part transferrin receptor protein 1
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002016 ! CD71-low, GlyA-positive polychromatic erythroblast
relationship: RO:0002104 PR:000001460 ! has plasma membrane part glycophorin-A
creation_date: 2010-04-26T11:04:21Z
[Term]
id: CL:0002019
name: Ly-76 high reticulocyte
def: "A reticulocyte that is Ly76-high and is Kit-negative." [GOC:ak, GOC:tfm, PMID:18539294]
comment: Marker associated with mouse cells.
is_a: CL:0002422 {is_inferred="true"} ! enucleated reticulocyte
intersection_of: CL:0002422 ! enucleated reticulocyte
intersection_of: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse)
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002017 ! Kit-negative, Ly-76 high orthochromatophilic erythroblasts
relationship: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse)
creation_date: 2010-04-26T11:37:00Z
[Term]
id: CL:0002020
name: GlyA-positive reticulocytes
def: "A reticulocyte that is GlyA-positive." [GOC:ak, GOC:tfm, PMID:1638021]
comment: Markers is associated with human cells.
is_a: CL:0002422 {is_inferred="true"} ! enucleated reticulocyte
intersection_of: CL:0002422 ! enucleated reticulocyte
intersection_of: RO:0002104 PR:000001460 ! has plasma membrane part glycophorin-A
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002018 ! CD71-negative, GlyA-positive orthochromatic erythroblast
relationship: RO:0002104 PR:000001460 ! has plasma membrane part glycophorin-A
creation_date: 2010-04-26T11:48:25Z
[Term]
id: CL:0002021
name: GlyA-positive erythrocyte
def: "An enucleate erythrocyte that is GlyA-positive." [GOC:ak, GOC:tfm, PMID:20134094]
comment: Marker is associated with human cell types.
is_a: CL:0000595 {is_inferred="true"} ! enucleate erythrocyte
intersection_of: CL:0000595 ! enucleate erythrocyte
intersection_of: RO:0002104 PR:000001460 ! has plasma membrane part glycophorin-A
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002020 ! GlyA-positive reticulocytes
relationship: RO:0002104 PR:000001460 ! has plasma membrane part glycophorin-A
creation_date: 2010-04-26T11:51:22Z
[Term]
id: CL:0002022
name: Ly-76 high positive erythrocyte
def: "An enucleate erythrocyte that is Lyg-76-high." [GOC:ak, GOC:tfm, PMID:19805084]
comment: Marker is associated with mouse cell types.
is_a: CL:0000595 {is_inferred="true"} ! enucleate erythrocyte
intersection_of: CL:0000595 ! enucleate erythrocyte
intersection_of: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse)
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002019 ! Ly-76 high reticulocyte
relationship: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse)
creation_date: 2010-04-26T11:51:27Z
[Term]
id: CL:0002031
name: hematopoietic lineage restricted progenitor cell
def: "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells." [GOC:tfm, PMID:19022770]
subset: blood_and_immune_upper_slim
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0008001 ! hematopoietic precursor cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: RO:0000053 PATO:0001400 ! has characteristic unipotent
disjoint_from: CL:0002032 ! hematopoietic oligopotent progenitor cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002032 ! hematopoietic oligopotent progenitor cell
relationship: RO:0000053 PATO:0001400 ! has characteristic unipotent
creation_date: 2010-01-06T03:43:20Z
[Term]
id: CL:0002032
name: hematopoietic oligopotent progenitor cell
def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities." [GOC:tfm, https://orcid.org/0000-0001-5208-3432, PMID:19022770]
comment: This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060).
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0008001 ! hematopoietic precursor cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: RO:0000053 PATO:0001401 ! has characteristic oligopotent
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0000837 ! hematopoietic multipotent progenitor cell
relationship: RO:0000053 PATO:0001401 ! has characteristic oligopotent
creation_date: 2010-01-06T03:43:27Z
[Term]
id: CL:0002033
name: short term hematopoietic stem cell
def: "A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative." [GOC:tfm, PMID:15572596, PMID:19022770]
comment: Markers are associated with mouse cells. These cells are also reportedly CD11b-low and CD90-low.
synonym: "ST stem cell" EXACT []
synonym: "ST-HSC" EXACT []
is_a: CL:0001008 {is_inferred="true"} ! Kit and Sca1-positive hematopoietic stem cell
intersection_of: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell
intersection_of: CL:4030046 PR:000002001 ! lacks_plasma_membrane_part receptor-type tyrosine-protein kinase FLT3
intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
intersection_of: RO:0002104 PR:000001833 ! has plasma membrane part SLAM family member 1
relationship: CL:4030046 PR:000002001 ! lacks_plasma_membrane_part receptor-type tyrosine-protein kinase FLT3
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002034 ! long term hematopoietic stem cell
relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
relationship: RO:0002104 PR:000001833 ! has plasma membrane part SLAM family member 1
creation_date: 2010-01-08T09:19:25Z
[Term]
id: CL:0002034
name: long term hematopoietic stem cell
def: "A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative." [GOC:tfm, PMID:15572596, PMID:17582345]
comment: Markers are associated with mouse cells.
synonym: "LT stem cell" EXACT []
synonym: "LT-HSC" EXACT []
is_a: CL:0001008 {is_inferred="true"} ! Kit and Sca1-positive hematopoietic stem cell
intersection_of: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell
intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule
intersection_of: CL:4030046 PR:000002001 ! lacks_plasma_membrane_part receptor-type tyrosine-protein kinase FLT3
intersection_of: RO:0002104 PR:000001833 ! has plasma membrane part SLAM family member 1
intersection_of: RO:0015016 PR:000001843 ! has low plasma membrane amount Thy-1 membrane glycoprotein
relationship: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule
relationship: CL:4030046 PR:000002001 ! lacks_plasma_membrane_part receptor-type tyrosine-protein kinase FLT3
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: RO:0002104 PR:000001833 ! has plasma membrane part SLAM family member 1
relationship: RO:0015016 PR:000001843 ! has low plasma membrane amount Thy-1 membrane glycoprotein
creation_date: 2010-01-08T09:19:28Z
[Term]
id: CL:0002035
name: Slamf1-negative multipotent progenitor cell
def: "A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative." [GOC:tfm, PMID:19022770]
comment: Markers are associated with mouse cells.
is_a: CL:0000837 {is_inferred="true"} ! hematopoietic multipotent progenitor cell
intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell
intersection_of: CL:4030046 PR:000001833 ! lacks_plasma_membrane_part SLAM family member 1
intersection_of: CL:4030046 PR:000002001 ! lacks_plasma_membrane_part receptor-type tyrosine-protein kinase FLT3
intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor
intersection_of: RO:0002104 PR:000002979 ! has plasma membrane part lymphocyte antigen 6A-2/6E-1
relationship: CL:4030046 PR:000001833 ! lacks_plasma_membrane_part SLAM family member 1
relationship: CL:4030046 PR:000002001 ! lacks_plasma_membrane_part receptor-type tyrosine-protein kinase FLT3
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002036 ! Slamf1-positive multipotent progenitor cell
relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor
relationship: RO:0002104 PR:000002979 ! has plasma membrane part lymphocyte antigen 6A-2/6E-1
creation_date: 2010-01-08T11:16:33Z
[Term]
id: CL:0002036
name: Slamf1-positive multipotent progenitor cell
def: "A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive." [GOC:tfm, PMID:19022770]
comment: Markers are associated with mouse cells.
synonym: "KSL cell" EXACT []
is_a: CL:0000837 {is_inferred="true"} ! hematopoietic multipotent progenitor cell
intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell
intersection_of: RO:0002104 PR:000001833 ! has plasma membrane part SLAM family member 1
intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor
intersection_of: RO:0002104 PR:000002979 ! has plasma membrane part lymphocyte antigen 6A-2/6E-1
disjoint_from: CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002033 ! short term hematopoietic stem cell
relationship: RO:0002104 PR:000001833 ! has plasma membrane part SLAM family member 1
relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor
relationship: RO:0002104 PR:000002979 ! has plasma membrane part lymphocyte antigen 6A-2/6E-1
creation_date: 2010-01-08T11:16:35Z
[Term]
id: CL:0002043
name: CD34-positive, CD38-negative multipotent progenitor cell
def: "A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative." [GOC:tfm, PMID:18371405, PMID:19022770]
comment: Cell markers are associated with human hematopoietic multipotent progenitor cells.
is_a: CL:0000837 {is_inferred="true"} ! hematopoietic multipotent progenitor cell
intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell
intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
intersection_of: CL:4030046 PR:000001843 ! lacks_plasma_membrane_part Thy-1 membrane glycoprotein
intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
relationship: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
relationship: CL:4030046 PR:000001843 ! lacks_plasma_membrane_part Thy-1 membrane glycoprotein
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0001024 ! CD34-positive, CD38-negative hematopoietic stem cell
relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
creation_date: 2010-01-12T11:14:15Z
[Term]
id: CL:0002045
name: fraction A pre-pro B cell
def: "A pro-B cell that is CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive." [GOC:ak, GOC:tfm, http://www.immgen.org/index_content.html, PMID:12633665, PMID:17582343, PMID:37442242]
comment: Markers associated with mouse cells.
subset: cellxgene_subset
synonym: "fraction A" BROAD []
synonym: "pre pro B cell" RELATED []
is_a: CL:0000826 {is_inferred="true"} ! pro-B cell
intersection_of: CL:0000826 ! pro-B cell
intersection_of: CL:4030046 PR:000002039 ! lacks_plasma_membrane_part glutamyl aminopeptidase
intersection_of: CL:4030046 PR:000002980 ! lacks_plasma_membrane_part lymphocyte antigen 6C2
intersection_of: in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: RO:0002104 PR:000001879 ! has plasma membrane part leukosialin
intersection_of: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor
intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor
intersection_of: RO:0015016 PR:000001932 ! has low plasma membrane amount signal transducer CD24
relationship: CL:4030046 PR:000002039 ! lacks_plasma_membrane_part glutamyl aminopeptidase
relationship: CL:4030046 PR:000002980 ! lacks_plasma_membrane_part lymphocyte antigen 6C2
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: in_taxon NCBITaxon:10090 ! Mus musculus
relationship: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: RO:0002104 PR:000001879 ! has plasma membrane part leukosialin
relationship: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor
relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor
relationship: RO:0015016 PR:000001932 ! has low plasma membrane amount signal transducer CD24
creation_date: 2010-04-28T10:50:07Z
[Term]
id: CL:0002047
name: fraction B precursor B cell
def: "A precursor B cell that is CD45RA-positive, CD43-positive, CD24-positive and BP-1-negative." [GOC:ak, GOC:tfm, PMID:18432934, PMID:37442242]
comment: Markers are commonly associated with mouse cells. These cells are also reportedly RAG1-positive and RAG2-positive.
synonym: "Fr. B" BROAD []
synonym: "Fraction B" BROAD []
is_a: CL:0002400 {is_inferred="true"} ! fraction B/C precursor B cell
intersection_of: CL:0002400 ! fraction B/C precursor B cell
intersection_of: CL:4030046 PR:000002039 ! lacks_plasma_membrane_part glutamyl aminopeptidase
intersection_of: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
intersection_of: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24
relationship: CL:4030046 PR:000002039 ! lacks_plasma_membrane_part glutamyl aminopeptidase
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002045 ! fraction A pre-pro B cell
relationship: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
relationship: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24
creation_date: 2010-04-28T11:56:21Z
[Term]
id: CL:0002049
name: fraction C precursor B cell
def: "A precursor B cell that is CD45R-positive, CD43-positive, CD24-positive, and BP-positive. Intracellularly expression of surrogate light chain, Rag1 and Rag2, TdT, occurs while there is no expression of mu heavy chain." [GOC:tfm, PMID:17582343, PMID:37442242]
synonym: "Fraction C" RELATED []
is_a: CL:0002400 {is_inferred="true"} ! fraction B/C precursor B cell
intersection_of: CL:0002400 ! fraction B/C precursor B cell
intersection_of: CL:4030044 GO:0071707 ! has_not_completed immunoglobulin heavy chain V-D-J recombination
intersection_of: has_part PR:000001858 ! immunoglobulin iota chain
intersection_of: has_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1
intersection_of: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
intersection_of: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24
intersection_of: RO:0002104 PR:000002039 ! has plasma membrane part glutamyl aminopeptidase
intersection_of: RO:0002104 PR:000003457 ! has plasma membrane part V(D)J recombination-activating protein 1
intersection_of: RO:0002104 PR:000003460 ! has plasma membrane part V(D)J recombination-activating protein 2
relationship: CL:4030044 GO:0071707 ! has_not_completed immunoglobulin heavy chain V-D-J recombination
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002047 ! fraction B precursor B cell
relationship: has_part PR:000001858 ! immunoglobulin iota chain
relationship: has_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1
relationship: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
relationship: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24
relationship: RO:0002104 PR:000002039 ! has plasma membrane part glutamyl aminopeptidase
relationship: RO:0002104 PR:000003457 ! has plasma membrane part V(D)J recombination-activating protein 1
relationship: RO:0002104 PR:000003460 ! has plasma membrane part V(D)J recombination-activating protein 2
creation_date: 2010-04-28T02:04:01Z
[Term]
id: CL:0002050
name: fraction C' precursor B cell
def: "A pre-BCR-positive precursor B cell that is CD24-high, CD25-positive, CD43-positive, CD45R-positive and BP-positive." [GOC:tfm, PMID:17582343, PMID:37442242]
synonym: "Fr. C'" BROAD []
synonym: "Fraction C-prime" BROAD []
is_a: CL:0000817 {is_inferred="true"} ! precursor B cell
intersection_of: CL:0000817 ! precursor B cell
intersection_of: in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: RO:0002104 GO:0035369 ! has plasma membrane part pre-B cell receptor complex
intersection_of: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
intersection_of: RO:0002104 PR:000001380 ! has plasma membrane part interleukin-2 receptor subunit alpha
intersection_of: RO:0002104 PR:000001879 ! has plasma membrane part leukosialin
intersection_of: RO:0002104 PR:000002039 ! has plasma membrane part glutamyl aminopeptidase
intersection_of: RO:0015015 PR:000001932 ! has high plasma membrane amount signal transducer CD24
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002049 ! fraction C precursor B cell
relationship: in_taxon NCBITaxon:10090 ! Mus musculus
relationship: RO:0002104 GO:0035369 ! has plasma membrane part pre-B cell receptor complex
relationship: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
relationship: RO:0002104 PR:000001380 ! has plasma membrane part interleukin-2 receptor subunit alpha
relationship: RO:0002104 PR:000001879 ! has plasma membrane part leukosialin
relationship: RO:0002104 PR:000002039 ! has plasma membrane part glutamyl aminopeptidase
relationship: RO:0015015 PR:000001932 ! has high plasma membrane amount signal transducer CD24
creation_date: 2010-04-28T02:13:46Z
[Term]
id: CL:0002052
name: fraction D precursor B cell
def: "A pre-B cell that is pre-BCR-negative, and the kappa- and lambda- light immunoglobulin light chain-negative, CD43-low, and is BP-1-positive, CD45R-positive and CD25-positive. This cell type is also described as being AA4-positive, IgM-negative, CD19-positive, CD43-low/negative, and HSA-positive." [GOC:ak, GOC:dsd, GOC:tfm, http://www.immgen.org/index_content.html, PMID:17582343, PMID:18432934, PMID:37442242]
comment: Fraction D precursor B cells are also reportedly CD24-positive and sIgD-negative.
synonym: "Fr. D" BROAD []
synonym: "fraction D pre-B cell" EXACT [GOC:tfm]
is_a: CL:0002400 ! fraction B/C precursor B cell
intersection_of: CL:0000817 ! precursor B cell
intersection_of: CL:4030044 GO:0071708 ! has_not_completed immunoglobulin light chain V-J recombination
intersection_of: CL:4030046 GO:0035369 ! lacks_plasma_membrane_part pre-B cell receptor complex
intersection_of: in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: RO:0002104 PR:000001002 ! has plasma membrane part CD19 molecule
intersection_of: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
intersection_of: RO:0002104 PR:000001380 ! has plasma membrane part interleukin-2 receptor subunit alpha
intersection_of: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24
intersection_of: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor
intersection_of: RO:0002104 PR:000002039 ! has plasma membrane part glutamyl aminopeptidase
intersection_of: RO:0015016 PR:000001879 ! has low plasma membrane amount leukosialin
relationship: CL:4030044 GO:0071708 ! has_not_completed immunoglobulin light chain V-J recombination
relationship: CL:4030046 GO:0035369 ! lacks_plasma_membrane_part pre-B cell receptor complex
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002050 ! fraction C' precursor B cell
relationship: in_taxon NCBITaxon:10090 ! Mus musculus
relationship: RO:0002104 PR:000001002 ! has plasma membrane part CD19 molecule
relationship: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
relationship: RO:0002104 PR:000001380 ! has plasma membrane part interleukin-2 receptor subunit alpha
relationship: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24
relationship: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor
relationship: RO:0002104 PR:000002039 ! has plasma membrane part glutamyl aminopeptidase
relationship: RO:0015016 PR:000001879 ! has low plasma membrane amount leukosialin
creation_date: 2010-04-28T02:55:16Z
[Term]
id: CL:0002054
name: fraction E immature B cell
def: "An immature B cell that is IgM-positive, CD45R-positive, CD43-low, CD25-negative, and CD127-negative. This cell type has also been described as being AA4-positive, IgM-positive, CD19-positive, CD43-low/negative, and HSA-positive." [GOC:ak, GOC:dsd, GOC:tfm, PMID:17582343, PMID:18432934, PMID:37442242]
comment: Markers associated with mouse cells. These cells are also reportedly sIgD-negative.
is_a: CL:0000816 {is_inferred="true"} ! immature B cell
intersection_of: CL:0000816 ! immature B cell
intersection_of: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha
intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha
intersection_of: in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: RO:0002104 PR:000001002 ! has plasma membrane part CD19 molecule
intersection_of: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24
intersection_of: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor
intersection_of: RO:0015016 PR:000001879 ! has low plasma membrane amount leukosialin
relationship: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha
relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002052 ! fraction D precursor B cell
relationship: in_taxon NCBITaxon:10090 ! Mus musculus
relationship: RO:0002104 PR:000001002 ! has plasma membrane part CD19 molecule
relationship: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24
relationship: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor
relationship: RO:0015016 PR:000001879 ! has low plasma membrane amount leukosialin
creation_date: 2010-04-28T03:13:47Z
[Term]
id: CL:0002056
name: fraction F mature B cell
def: "A mature B cell subset originally defined as having being CD45R-positive, IgM-positive, IgD-positive and CD43-negative. Subsequent research demonstrated being CD21-positive and CD23-negative and CD93 negative." [GOC:tfm, PMID:17582343, PMID:37442242]
is_a: CL:0000822 ! B-2 B cell
intersection_of: CL:0000785 ! mature B cell
intersection_of: CL:4030046 PR:000001879 ! lacks_plasma_membrane_part leukosialin
intersection_of: CL:4030046 PR:000001880 ! lacks_plasma_membrane_part low affinity immunoglobulin epsilon Fc receptor
intersection_of: CL:4030046 PR:000002037 ! lacks_plasma_membrane_part complement component C1q receptor
intersection_of: in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex
intersection_of: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex
intersection_of: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
intersection_of: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1
intersection_of: RO:0002104 PR:000001338 ! has plasma membrane part complement receptor type 2
relationship: CL:4030046 PR:000001879 ! lacks_plasma_membrane_part leukosialin
relationship: CL:4030046 PR:000001880 ! lacks_plasma_membrane_part low affinity immunoglobulin epsilon Fc receptor
relationship: CL:4030046 PR:000002037 ! lacks_plasma_membrane_part complement component C1q receptor
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002054 ! fraction E immature B cell
relationship: in_taxon NCBITaxon:10090 ! Mus musculus
relationship: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex
relationship: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex
relationship: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
relationship: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1
relationship: RO:0002104 PR:000001338 ! has plasma membrane part complement receptor type 2
creation_date: 2010-04-30T03:01:48Z
[Term]
id: CL:0002059
name: CD8-alpha-positive thymic conventional dendritic cell
def: "A conventional thymic dendritic cell that is CD8-alpha-positive." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:19273629]
subset: human_reference_atlas
synonym: "CD8alpha-alpha-positive thymic conventional dendritic cell" EXACT []
synonym: "DC.8+.Th" EXACT []
is_a: CL:0000941 {is_inferred="true"} ! thymic conventional dendritic cell
intersection_of: CL:0000941 ! thymic conventional dendritic cell
intersection_of: RO:0002104 PR:000001084 ! has plasma membrane part T-cell surface glycoprotein CD8 alpha chain
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 PR:000001084 ! has plasma membrane part T-cell surface glycoprotein CD8 alpha chain
creation_date: 2010-06-07T02:48:36Z
[Term]
id: CL:0002062
name: pulmonary alveolar type 1 cell
def: "A squamous pulmonary alveolar epithelial cell that is flattened and branched. A pulmonary alveolar type 1 cell covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange." [GOC:tfm, http://www.copewithcytokines.de, PMID:20054144, PMID:29463737]
comment: The marker set AGER can identify the Human cell type pulmonary alveolar type 1 cell in the lung with a confidence of 0.85 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"}
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "AT1" RELATED OMO:0003000 [PMID:29463737]
synonym: "ATI" RELATED OMO:0003000 []
synonym: "lung type 1 cells" EXACT []
synonym: "membranous pneumocytes" EXACT []
synonym: "pulmonary alveolar type I cell" EXACT []
synonym: "small alveolar cells" EXACT []
synonym: "squamous alveolar cell" EXACT []
synonym: "squamous alveolar lining cell" EXACT []
synonym: "type 1 alveolar epithelial cells" EXACT []
synonym: "type 1 pneumocyte" EXACT [PMID:32491474]
synonym: "type I alveolar cells" EXACT []
synonym: "type I alveolar epithelial cells" EXACT []
synonym: "type I pneumocyte" EXACT []
xref: BTO:0000780
xref: FMA:62500
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0000322 ! pulmonary alveolar epithelial cell
intersection_of: CL:0000322 ! pulmonary alveolar epithelial cell
intersection_of: capable_of GO:0007585 ! respiratory gaseous exchange by respiratory system
relationship: capable_of GO:0007585 ! respiratory gaseous exchange by respiratory system
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0015004 CLM:1000008 ! has characterizing marker set
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002062" xsd:string {name="pulmonary alveolar type 1 cell on CELLxGENE CellGuide"}
creation_date: 2010-06-23T04:37:54Z
[Term]
id: CL:0002063
name: pulmonary alveolar type 2 cell
def: "A pulmonary alveolar epithelial cell that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants via specialized organelles called alveolar lamellar bodies. This cell type also contributes to tissue repair and can differentiate after injury into a pulmonary alveolar type 1 cell. This cuboidal cell is thicker than squamous alveolar cells, has a rounded apical surface that projects above the level of the surrounding epithelium, and its free surface is covered by short microvilli." [GOC:tfm, http://www.copewithcytokines.de, ISBN:0412046911, PMID:36138472, PMID:8540632]
comment: The marker set SFTPA1 can identify the Human cell type pulmonary alveolar type 2 cell in the lung with a confidence of 0.95 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"}
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "AT2" RELATED OMO:0003000 [PMID:36138472]
synonym: "ATII" RELATED OMO:0003000 []
synonym: "cuboidal type II cell" EXACT []
synonym: "granular pneumocyte" EXACT []
synonym: "great alveolar cell" EXACT []
synonym: "lung type 2 cell" EXACT []
synonym: "lung type II cell" RELATED []
synonym: "TII" RELATED []
synonym: "type 2 alveolar epithelial cell" EXACT []
synonym: "type 2 alveolocyte" EXACT []
synonym: "type 2 pneumocyte" EXACT []
synonym: "type II alveolar cell" EXACT []
synonym: "type II alveolar epithelial cell" EXACT []
synonym: "type II alveolocyte" EXACT []
synonym: "type II pneumocyte" EXACT [PMID:32491474]
xref: BTO:0000538
xref: FMA:62501
is_a: CL:0000157 ! surfactant secreting cell
is_a: CL:0000322 ! pulmonary alveolar epithelial cell
is_a: CL:0008055 ! respiratory tract secretory epithelial cell
is_a: CL:1000272 ! lung secretory cell
intersection_of: CL:0000322 ! pulmonary alveolar epithelial cell
intersection_of: capable_of GO:0032940 ! secretion by cell
intersection_of: capable_of GO:0043129 ! surfactant homeostasis
relationship: capable_of GO:0032940 ! secretion by cell
relationship: capable_of GO:0043129 ! surfactant homeostasis
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:4040003 ! fetal pre-type II pulmonary alveolar epithelial cell
relationship: has_part GO:0097208 ! alveolar lamellar body
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0000053 PATO:0001872 ! has characteristic cuboid
relationship: RO:0015004 CLM:1000009 ! has characterizing marker set
creation_date: 2010-06-24T12:04:13Z
[Term]
id: CL:0002064
name: pancreatic acinar cell
def: "A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules." [GOC:tfm, http://www.copewithcytokines.de/cope.cgi?key=pancreatic%20acinar%20cells, ISBN:0517223651, PMID:20395539]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "acinar cell of pancreas" EXACT []
xref: BTO:0000028
xref: CALOHA:TS-0737
xref: FMA:63032
xref: ZFA:0005739 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000622 {is_inferred="true"} ! acinar cell
is_a: CL:1001599 ! pancreas exocrine glandular cell
intersection_of: CL:0000622 ! acinar cell
intersection_of: part_of UBERON:0001263 ! pancreatic acinus
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: has_part GO:0042589 ! zymogen granule membrane
relationship: part_of UBERON:0001263 ! pancreatic acinus
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002064" xsd:string {name="pancreatic acinar cell on CELLxGENE CellGuide"}
creation_date: 2010-06-24T03:16:29Z
[Term]
id: CL:0002067
name: type A enteroendocrine cell
def: "An enteroendocrine cell that produces glucagon." [GOC:tfm, ISBN:0412046911]
subset: cellxgene_subset
xref: FMA:62939
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000170 ! glucagon secreting cell
intersection_of: CL:0000164 ! enteroendocrine cell
intersection_of: capable_of GO:0070091 ! glucagon secretion
relationship: capable_of GO:0070091 ! glucagon secretion
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002067" xsd:string {name="type A enteroendocrine cell on CELLxGENE CellGuide"}
creation_date: 2010-09-10T10:48:54Z
[Term]
id: CL:0002068
name: Purkinje myocyte
def: "Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter." [FMA:0412046911, GOC:tfm, PMID:19939742]
subset: human_reference_atlas
synonym: "myocytus conducens cardiacus" EXACT []
synonym: "Purkinje cell fiber" EXACT []
synonym: "Purkinje muscle cell" EXACT []
xref: BTO:0001032
xref: FMA:14146
is_a: CL:0002086 ! specialized cardiac myocyte
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2010-06-28T08:36:15Z
[Term]
id: CL:0002069
name: type II vestibular sensory cell
def: "Mostly cylindrical, resemble Type 1 in their contents and the presence of a kinocilium and stereocilium apically; much greater variation in size, some almost span the entire thickness of the sensory epithelium, while others are smaller than Type 1; receive multiple efferent nerve boutons around their bases as well as afferent endings, which are small expansions rather than chalices." [GOC:tfm, ISBN:0517223651]
synonym: "type 2 vestibular hair cell" EXACT []
synonym: "type 2 vestibular sensory cell" EXACT []
synonym: "type II hair cell" EXACT []
xref: FMA:67909
is_a: CL:0000609 ! vestibular hair cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-06-29T09:58:13Z
[Term]
id: CL:0002070
name: type I vestibular sensory cell
def: "Bottle-shaped with narrow neck; broad, rounded basal portion where nucleus is located; stereocilia and a single kinocilium is present apically; receive nerve bouton at their base from an afferent cup-shaped (chalice or calyx) nerve ending." [GOC:tfm, ISBN:0517223651]
synonym: "type 1 vestibular hair cell" EXACT []
synonym: "type 1 vestibular sensory cell" EXACT []
synonym: "type I hair cell" EXACT []
xref: FMA:62352
is_a: CL:0000609 ! vestibular hair cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-06-29T09:58:19Z
[Term]
id: CL:0002072
name: nodal myocyte
def: "A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery." [FMA:67101, GOC:tfm]
subset: human_reference_atlas
synonym: "cardiac pacemaker cell" EXACT [GOC:pr]
synonym: "myocytus nodalis" EXACT []
synonym: "P cell" EXACT []
synonym: "pacemaker cell" BROAD []
xref: BTO:0004190
xref: FMA:67101
is_a: CL:0002086 ! specialized cardiac myocyte
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2010-06-29T11:41:37Z
[Term]
id: CL:0002073
name: transitional myocyte
def: "Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes." [FMA:67142, GOC:tfm]
xref: FMA:67142
is_a: CL:0002086 ! specialized cardiac myocyte
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-06-29T02:39:32Z
[Term]
id: CL:0002074
name: myocardial endocrine cell
def: "The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides)." [FMA:67111, GOC:tfm]
xref: FMA:67111
is_a: CL:0000163 ! endocrine cell
is_a: CL:0002086 ! specialized cardiac myocyte
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-06-29T11:50:47Z
[Term]
id: CL:0002075
name: brush cell of tracheobronchial tree
def: "A rare type of columnar epithelial cell that is part of the tracheobronchial epithelium. This cell is characterized by a distinctive tuft of apical microvilli, which extends into the cytoplasm, and a pear-shaped morphology, broad at the base and tapering to a narrow apex. It plays vital roles in chemosensation, producing cytokines like IL-25, and enhancing mucociliary clearance through acetylcholine release to support mucus movement and airway defense." [GOC:tfm, ISBN:0517223651, PMID:15817800, PMID:30291131, PMID:37925434]
comment: The marker set POU2F3, HOMER3, MYB can identify the Human cell type brush cell of tracheobronchial tree in the lung with a confidence of 0.56 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"}
subset: cellxgene_subset
synonym: "pulmonary brush cell" RELATED []
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
is_a: CL:0002202 ! epithelial cell of tracheobronchial tree
is_a: CL:0002204 ! tuft cell
intersection_of: CL:0002204 ! tuft cell
intersection_of: part_of UBERON:0008397 ! tracheobronchial epithelium
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0008397 ! tracheobronchial epithelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0015004 CLM:1000061 ! has characterizing marker set
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002075" xsd:string {name="brush cell of tracheobronchial tree on CELLxGENE CellGuide"}
creation_date: 2010-06-29T03:22:46Z
[Term]
id: CL:0002076
name: endo-epithelial cell
def: "An epithelial cell derived from endoderm." [FMA:69075, GOC:tfm]
subset: cellxgene_subset
xref: FMA:69075
xref: ZFA:0009383 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: develops_from CL:0000223 ! endodermal cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0000223 ! endodermal cell
creation_date: 2010-06-29T03:38:14Z
[Term]
id: CL:0002077
name: ecto-epithelial cell
def: "An epithelial cell derived from ectoderm." [FMA:69074, GOC:tfm]
xref: FMA:69074
xref: ZFA:0009385 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: develops_from CL:0000221 ! ectodermal cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0000221 ! ectodermal cell
creation_date: 2010-06-29T03:38:22Z
[Term]
id: CL:0002078
name: meso-epithelial cell
def: "Epithelial cell derived from mesoderm or mesenchyme." [FMA:69076, GOC:tfm]
synonym: "epithelial mesenchymal cell" EXACT []
xref: FMA:69076
xref: ZFA:0009388 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: develops_from CL:0000222 ! mesodermal cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0000222 ! mesodermal cell
creation_date: 2010-06-29T03:49:14Z
[Term]
id: CL:0002079
name: pancreatic ductal cell
def: "Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH." [FMA:63099, GOC:tfm, PMID:14740223]
subset: cellxgene_subset
subset: human_reference_atlas
xref: FMA:63099
xref: ZFA:0009380 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000069 ! branched duct epithelial cell
is_a: CL:1001433 ! epithelial cell of exocrine pancreas
intersection_of: CL:0000083 ! epithelial cell of pancreas
intersection_of: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity
intersection_of: part_of UBERON:0001064 ! ventral pancreatic duct
relationship: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001064 ! ventral pancreatic duct
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002079" xsd:string {name="pancreatic ductal cell on CELLxGENE CellGuide"}
creation_date: 2010-06-30T08:49:43Z
[Term]
id: CL:0002080
name: pancreatic centro-acinar cell
def: "A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types." [GOC:tfm, PMID:12142741, PMID:20018761, PMID:8185160]
subset: human_reference_atlas
synonym: "centroacinar cell of Langerhans" EXACT []
synonym: "pancreatic centroacinar cell" EXACT []
xref: FMA:62455
xref: ZFA:0005740 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:1001433 ! epithelial cell of exocrine pancreas
intersection_of: CL:0000083 ! epithelial cell of pancreas
intersection_of: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity
intersection_of: part_of UBERON:0001263 ! pancreatic acinus
relationship: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001263 ! pancreatic acinus
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2010-06-30T08:49:52Z
[Term]
id: CL:0002081
name: type II cell of carotid body
def: "This cell resembles a glia cell, express the glial marker S100 and act as a supporting cell to type I cell. This cell is located in a small cluster of type I and type II cells near the fork of the carotid artery." [GOC:tfm, http://en.wikipedia.org/wiki/Carotid_body, PMID:7938227]
synonym: "sheath cell of carotid body" EXACT []
xref: FMA:84187
is_a: CL:0000703 ! sustentacular cell
is_a: CL:0002256 ! supporting cell of carotid body
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-06-30T04:23:42Z
[Term]
id: CL:0002082
name: type II cell of adrenal medulla
def: "A chromaffin cell of the adrenal medulla that produces epinephrine." [GOC:tfm]
synonym: "adrenal secreting cell of the adrenal medulla" EXACT []
synonym: "adrenergic chromaffin cell" EXACT []
synonym: "epiniphrine secreting cell of the adrenal medulla" EXACT []
xref: FMA:69322
is_a: CL:0000336 {is_inferred="true"} ! adrenal medulla chromaffin cell
is_a: CL:0000454 ! epinephrine secreting cell
intersection_of: CL:0000336 ! adrenal medulla chromaffin cell
intersection_of: capable_of GO:0048242 ! epinephrine secretion
intersection_of: part_of UBERON:0001236 ! adrenal medulla
relationship: capable_of GO:0048242 ! epinephrine secretion
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001236 ! adrenal medulla
creation_date: 2010-07-14T09:41:42Z
[Term]
id: CL:0002083
name: type I cell of adrenal medulla
def: "A chromaffin cell of the adrenal medulla that produces norepinephrine." [GOC:tfm, ISBN:068340007X]
synonym: "noradrenergic chromaffin cell" EXACT []
xref: FMA:69321
is_a: CL:0000336 {is_inferred="true"} ! adrenal medulla chromaffin cell
is_a: CL:0000459 ! noradrenergic cell
intersection_of: CL:0000336 ! adrenal medulla chromaffin cell
intersection_of: capable_of GO:0048243 ! norepinephrine secretion
intersection_of: part_of UBERON:0001236 ! adrenal medulla
relationship: capable_of GO:0048243 ! norepinephrine secretion
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001236 ! adrenal medulla
creation_date: 2010-07-14T10:12:24Z
[Term]
id: CL:0002086
name: specialized cardiac myocyte
def: "A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart." [FMA:67968, GOC:tfm]
xref: FMA:67968
is_a: CL:0000746 ! cardiac muscle cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-07-21T01:33:38Z
[Term]
id: CL:0002087
name: nongranular leukocyte
def: "A leukocyte that lacks granules." [GOC:tfm]
subset: blood_and_immune_upper_slim
synonym: "agranular leukocyte" EXACT []
xref: FMA:62855
is_a: CL:0000738 {is_inferred="true"} ! leukocyte
intersection_of: CL:0000738 ! leukocyte
intersection_of: CL:4030045 GO:0030141 ! lacks_part secretory granule
relationship: CL:4030045 GO:0030141 ! lacks_part secretory granule
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-07-22T11:30:33Z
[Term]
id: CL:0002088
name: interstitial cell of Cajal
def: "This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise." [GOC:tfm, PMID:16460275, PMID:19520112]
comment: Some argue this cell type is of mesenchymal origin.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "ICC" EXACT []
synonym: "intestinal pacemaker cell" EXACT [GOC:pr]
xref: BTO:0003914
xref: FMA:86573
is_a: CL:0000710 {is_inferred="true"} ! neurecto-epithelial cell
intersection_of: CL:0000710 ! neurecto-epithelial cell
intersection_of: capable_of GO:0043134 ! regulation of hindgut contraction
relationship: capable_of GO:0043134 ! regulation of hindgut contraction
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002088" xsd:string {name="interstitial cell of Cajal on CELLxGENE CellGuide"}
creation_date: 2010-07-22T03:26:00Z
[Term]
id: CL:0002090
name: polar body
def: "One of two small cells formed by the first and second meiotic division of oocytes." [GOC:tfm, http://en.wikipedia.org/wiki/Polar_body, ISBN:068340007X]
xref: EHDAA2:0004716
xref: FMA:85543
xref: MESH:D059705
xref: WBbt:0008429
xref: XAO:0000262
is_a: CL:0000021 ! female germ cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-08-23T09:49:53Z
[Term]
id: CL:0002092
name: bone marrow cell
def: "A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells." [GOC:tfm, ISBN:0618947256]
comment: MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense.
subset: cellxgene_subset
xref: BTO:0004850
xref: FMA:83621
xref: MESH:D001854
is_a: CL:0001035 {is_inferred="true"} ! bone cell
intersection_of: CL:0001035 ! bone cell
intersection_of: part_of UBERON:0002371 ! bone marrow
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002371 ! bone marrow
creation_date: 2010-07-22T04:48:15Z
[Term]
id: CL:0002095
name: hilus cell of ovary
def: "A cell in the hilum of the ovary that produces androgens." [GOC:tfm, ISBN:068340007X]
subset: human_reference_atlas
synonym: "hilar cell of ovary" EXACT []
xref: FMA:18710
is_a: CL:0000593 ! androgen secreting cell
is_a: CL:0002132 ! stromal cell of ovary
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2010-08-23T11:18:18Z
[Term]
id: CL:0002096
name: internodal tract myocyte
def: "A specialised myocyte that lies between the sinoatrial node and the atrioventricular node and is involved in the conduction of electrical signals." [GOC:tfm, ISBN:0781729300]
xref: FMA:223275
is_a: CL:0002086 ! specialized cardiac myocyte
is_a: CL:0008009 ! transversely striated visceral muscle cell
intersection_of: CL:0000187 ! muscle cell
intersection_of: part_of UBERON:0009966 ! internodal tract
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0009966 ! internodal tract
creation_date: 2010-08-23T11:24:11Z
[Term]
id: CL:0002097
name: cortical cell of adrenal gland
def: "A cell of the adrenal cortex. Cell types include those that synthesize and secrete chemical derivatives (steroids) of cholesterol." [GOC:tfm]
subset: cellxgene_subset
synonym: "adrenal cortex cell" EXACT []
synonym: "adrenocortical cell" EXACT []
xref: FMA:69545
is_a: CL:0000174 ! steroid hormone secreting cell
is_a: CL:0002078 {is_inferred="true"} ! meso-epithelial cell
is_a: CL:1001601 ! adrenal gland glandular cell
intersection_of: CL:0002078 ! meso-epithelial cell
intersection_of: part_of UBERON:0001235 ! adrenal cortex
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001235 ! adrenal cortex
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002097" xsd:string {name="cortical cell of adrenal gland on CELLxGENE CellGuide"}
creation_date: 2010-08-24T01:37:44Z
[Term]
id: CL:0002099
name: type I cell of adrenal cortex
def: "A small, polyhedral, cell found in rounded groups or curved columns with deeply staining nuclei, scanty basophilic cytoplasm and a few lipid droplets. This cell in the zona glomerulosa produces mineralocorticoids." [GOC:tfm, ISBN:0517223651]
subset: cellxgene_subset
synonym: "epithelial cell of zona glomerulosa of adrenal gland" EXACT []
xref: FMA:69273
is_a: CL:0000456 ! mineralocorticoid secreting cell
is_a: CL:0002097 {is_inferred="true"} ! cortical cell of adrenal gland
intersection_of: CL:0002097 ! cortical cell of adrenal gland
intersection_of: part_of UBERON:0002053 ! zona glomerulosa of adrenal gland
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002053 ! zona glomerulosa of adrenal gland
creation_date: 2010-08-24T01:42:02Z
[Term]
id: CL:0002101
name: CD38-positive naive B cell
def: "A CD38-positive naive B cell is a mature B cell that has the phenotype CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
synonym: "CD38+ naive B cell" EXACT []
synonym: "CD38+ naive B lymphocyte" EXACT []
synonym: "CD38+ naive B-cell" EXACT []
synonym: "CD38+ naive B-lymphocyte" EXACT []
synonym: "CD38-positive naive B lymphocyte" EXACT []
synonym: "CD38-positive naive B-cell" EXACT []
synonym: "CD38-positive naive B-lymphocyte" EXACT []
is_a: CL:0000788 {is_inferred="true"} ! naive B cell
intersection_of: CL:0000788 ! naive B cell
intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
[Term]
id: CL:0002102
name: CD38-negative naive B cell
def: "A CD38-negative naive B cell is a mature B cell that has the phenotype CD38-negative, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
subset: cellxgene_subset
synonym: "CD38- naive B cell" EXACT []
synonym: "CD38- naive B lymphocyte" EXACT []
synonym: "CD38- naive B-cell" EXACT []
synonym: "CD38- naive B-lymphocyte" EXACT []
synonym: "CD38-negative naive B lymphocyte" EXACT []
synonym: "CD38-negative naive B-cell" EXACT []
synonym: "CD38-negative naive B-lymphocyte" EXACT []
is_a: CL:0000788 {is_inferred="true"} ! naive B cell
intersection_of: CL:0000788 ! naive B cell
intersection_of: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
relationship: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
[Term]
id: CL:0002103
name: IgG-positive double negative memory B cell
def: "An IgG-positive double negative memory B cell is a double negative memory B cell with the phenotype IgG-positive, IgD-negative, and CD27-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
synonym: "IgG+ dn memory B cell" EXACT []
synonym: "IgG+ dn memory B lymphocyte" EXACT []
synonym: "IgG+ dn memory B-cell" EXACT []
synonym: "IgG+ dn memory B-lymphocyte" EXACT []
synonym: "IgG+ double negative memory B cell" EXACT []
synonym: "IgG+ double negative memory B lymphocyte" EXACT []
synonym: "IgG+ double negative memory B-cell" EXACT []
synonym: "IgG+ double negative memory B-lymphocyte" EXACT []
synonym: "IgG-positive dn memory B cell" EXACT []
synonym: "IgG-positive dn memory B lymphocyte" EXACT []
synonym: "IgG-positive dn memory B-cell" EXACT []
synonym: "IgG-positive dn memory B-lymphocyte" EXACT []
synonym: "IgG-positive double negative memory B lymphocyte" EXACT []
synonym: "IgG-positive double negative memory B-cell" EXACT []
synonym: "IgG-positive double negative memory B-lymphocyte" EXACT []
is_a: CL:0000981 {is_inferred="true"} ! double negative memory B cell
intersection_of: CL:0000981 ! double negative memory B cell
intersection_of: RO:0002104 GO:0071735 ! has plasma membrane part IgG immunoglobulin complex
relationship: RO:0002104 GO:0071735 ! has plasma membrane part IgG immunoglobulin complex
[Term]
id: CL:0002104
name: IgG-negative double negative memory B cell
def: "An IgG-negative double negative memory B cell is a double negative memory B cell with the phenotype IgG-negative, IgD-negative, and CD27-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
synonym: "IgG- dn memory B cell" EXACT []
synonym: "IgG- dn memory B lymphocyte" EXACT []
synonym: "IgG- dn memory B-cell" EXACT []
synonym: "IgG- dn memory B-lymphocyte" EXACT []
synonym: "IgG- double negative memory B cell" EXACT []
synonym: "IgG- double negative memory B lymphocyte" EXACT []
synonym: "IgG- double negative memory B-cell" EXACT []
synonym: "IgG- double negative memory B-lymphocyte" EXACT []
synonym: "IgG-negative dn memory B cell" EXACT []
synonym: "IgG-negative dn memory B lymphocyte" EXACT []
synonym: "IgG-negative dn memory B-cell" EXACT []
synonym: "IgG-negative dn memory B-lymphocyte" EXACT []
synonym: "IgG-negative double negative memory B lymphocyte" EXACT []
synonym: "IgG-negative double negative memory B-cell" EXACT []
synonym: "IgG-negative double negative memory B-lymphocyte" EXACT []
is_a: CL:0000981 {is_inferred="true"} ! double negative memory B cell
intersection_of: CL:0000981 ! double negative memory B cell
intersection_of: CL:4030046 GO:0071735 ! lacks_plasma_membrane_part IgG immunoglobulin complex
relationship: CL:4030046 GO:0071735 ! lacks_plasma_membrane_part IgG immunoglobulin complex
[Term]
id: CL:0002105
name: CD38-positive IgG memory B cell
def: "A CD38-positive IgG memory B cell is a class switched memory B cell that expresses IgG on the cell surface with the phenotype CD38-positive and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
synonym: "CD38+ IgG memory B cell" EXACT []
synonym: "CD38+ IgG memory B lymphocyte" EXACT []
synonym: "CD38+ IgG memory B-cell" EXACT []
synonym: "CD38+ IgG memory B-lymphocyte" EXACT []
synonym: "CD38-positive IgG memory B lymphocyte" EXACT []
synonym: "CD38-positive IgG memory B-cell" EXACT []
synonym: "CD38-positive IgG memory B-lymphocyte" EXACT []
is_a: CL:0000979 {is_inferred="true"} ! IgG memory B cell
intersection_of: CL:0000979 ! IgG memory B cell
intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
[Term]
id: CL:0002106
name: IgD-positive CD38-positive IgG memory B cell
def: "An IgD-positive CD38-positive IgG memory B cell is a CD38-positive IgG-positive class switched memory B cell that has class switched and expresses IgD on the cell surface with the phenotype IgD-positive, CD38-positive, and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
is_a: CL:0002105 {is_inferred="true"} ! CD38-positive IgG memory B cell
intersection_of: CL:0002105 ! CD38-positive IgG memory B cell
intersection_of: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex
relationship: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex
[Term]
id: CL:0002107
name: IgD-negative CD38-positive IgG memory B cell
def: "An IgD-negative CD38-positive IgG memory B cell is a CD38-positive IgG-positive that has class switched and lacks expression of IgD on the cell surface with the phenotype IgD-negative, CD38-positive, and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
is_a: CL:0002105 {is_inferred="true"} ! CD38-positive IgG memory B cell
is_a: CL:4052108 ! IgD-negative class switched memory B cell
intersection_of: CL:0002105 ! CD38-positive IgG memory B cell
intersection_of: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex
relationship: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex
[Term]
id: CL:0002108
name: CD38-negative IgG memory B cell
def: "A CD38-negative IgG memory B cell is a IgG-positive class switched memory B cell that has class switched and expresses IgG on the cell surface with the phenotype CD38-negative, IgD-negative, and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
is_a: CL:0000979 {is_inferred="true"} ! IgG memory B cell
is_a: CL:4052108 ! IgD-negative class switched memory B cell
intersection_of: CL:0000979 ! IgG memory B cell
intersection_of: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex
intersection_of: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
relationship: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex
relationship: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
[Term]
id: CL:0002109
name: B220-positive CD38-positive naive B cell
def: "A B220-positive CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-positive, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
synonym: "B220+CD38+ naive B cell" EXACT []
synonym: "B220+CD38+ naive B lymphocyte" EXACT []
synonym: "B220+CD38+ naive B-cell" EXACT []
synonym: "B220+CD38+ naive B-lymphocyte" EXACT []
synonym: "B220-positive CD38-positive naive B lymphocyte" EXACT []
synonym: "B220-positive CD38-positive naive B-cell" EXACT []
synonym: "B220-positive CD38-positive naive B-lymphocyte" EXACT []
synonym: "CD38+B220+ naive B cell" EXACT []
synonym: "CD38+B220+ naive B lymphocyte" EXACT []
synonym: "CD38+B220+ naive B-cell" EXACT []
synonym: "CD38+B220+ naive B-lymphocyte" EXACT []
is_a: CL:0002101 {is_inferred="true"} ! CD38-positive naive B cell
intersection_of: CL:0002101 ! CD38-positive naive B cell
intersection_of: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
relationship: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
[Term]
id: CL:0002110
name: B220-low CD38-positive naive B cell
def: "A B220-low CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-low, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
is_a: CL:0002109 ! B220-positive CD38-positive naive B cell
intersection_of: CL:0002101 ! CD38-positive naive B cell
intersection_of: RO:0015016 PR:000001014 ! has low plasma membrane amount receptor-type tyrosine-protein phosphatase C isoform CD45RABC
relationship: RO:0015016 PR:000001014 ! has low plasma membrane amount receptor-type tyrosine-protein phosphatase C isoform CD45RABC
[Term]
id: CL:0002111
name: CD38-negative unswitched memory B cell
def: "An CD38-negative unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-negative, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
synonym: "CD38- unswitched memory B cell" EXACT []
synonym: "CD38- unswitched memory B lymphocyte" EXACT []
synonym: "CD38- unswitched memory B-cell" EXACT []
synonym: "CD38- unswitched memory B-lymphocyte" EXACT []
synonym: "CD38-negative unswitched memory B lymphocyte" EXACT []
synonym: "CD38-negative unswitched memory B-cell" EXACT []
synonym: "CD38-negative unswitched memory B-lymphocyte" EXACT []
is_a: CL:0000970 {is_inferred="true"} ! unswitched memory B cell
intersection_of: CL:0000970 ! unswitched memory B cell
intersection_of: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
relationship: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
[Term]
id: CL:0002112
name: B220-positive CD38-negative unswitched memory B cell
def: "A B220-positive CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-positive, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
is_a: CL:0002111 {is_inferred="true"} ! CD38-negative unswitched memory B cell
intersection_of: CL:0002111 ! CD38-negative unswitched memory B cell
intersection_of: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
relationship: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
[Term]
id: CL:0002113
name: B220-low CD38-negative unswitched memory B cell
def: "A B220-low CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-low, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
is_a: CL:0002112 ! B220-positive CD38-negative unswitched memory B cell
intersection_of: CL:0002111 ! CD38-negative unswitched memory B cell
intersection_of: RO:0015016 PR:000001014 ! has low plasma membrane amount receptor-type tyrosine-protein phosphatase C isoform CD45RABC
relationship: RO:0015016 PR:000001014 ! has low plasma membrane amount receptor-type tyrosine-protein phosphatase C isoform CD45RABC
[Term]
id: CL:0002114
name: CD38-positive unswitched memory B cell
def: "A CD38-positive unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-positive, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
synonym: "CD38+ unswitched memory B cell" EXACT []
synonym: "CD38+ unswitched memory B lymphocyte" EXACT []
synonym: "CD38+ unswitched memory B-cell" EXACT []
synonym: "CD38+ unswitched memory B-lymphocyte" EXACT []
synonym: "CD38-positive unswitched memory B lymphocyte" EXACT []
synonym: "CD38-positive unswitched memory B-cell" EXACT []
synonym: "CD38-positive unswitched memory B-lymphocyte" EXACT []
is_a: CL:0000970 {is_inferred="true"} ! unswitched memory B cell
intersection_of: CL:0000970 ! unswitched memory B cell
intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
[Term]
id: CL:0002115
name: B220-positive CD38-positive unswitched memory B cell
def: "A B220-positive CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-positive, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
is_a: CL:0002114 {is_inferred="true"} ! CD38-positive unswitched memory B cell
intersection_of: CL:0002114 ! CD38-positive unswitched memory B cell
intersection_of: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
relationship: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
[Term]
id: CL:0002116
name: B220-low CD38-positive unswitched memory B cell
def: "A B220-low CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-low, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
is_a: CL:0002115 ! B220-positive CD38-positive unswitched memory B cell
intersection_of: CL:0002114 ! CD38-positive unswitched memory B cell
intersection_of: RO:0015016 PR:000001014 ! has low plasma membrane amount receptor-type tyrosine-protein phosphatase C isoform CD45RABC
relationship: RO:0015016 PR:000001014 ! has low plasma membrane amount receptor-type tyrosine-protein phosphatase C isoform CD45RABC
[Term]
id: CL:0002117
name: IgG-negative class switched memory B cell
def: "A class switched memory B cell that lacks IgG on the cell surface." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
subset: cellxgene_subset
synonym: "IgG- class switched memory B cell" EXACT []
synonym: "IgG- class switched memory B lymphocyte" EXACT []
synonym: "IgG- class switched memory B-cell" EXACT []
synonym: "IgG- class switched memory B-lymphocyte" EXACT []
synonym: "IgG-negative class switched memory B lymphocyte" EXACT []
synonym: "IgG-negative class switched memory B-cell" EXACT []
synonym: "IgG-negative class switched memory B-lymphocyte" EXACT []
is_a: CL:4052108 ! IgD-negative class switched memory B cell
intersection_of: CL:0000972 ! class switched memory B cell
intersection_of: CL:4030046 GO:0071735 ! lacks_plasma_membrane_part IgG immunoglobulin complex
relationship: CL:4030046 GO:0071735 ! lacks_plasma_membrane_part IgG immunoglobulin complex
[Term]
id: CL:0002118
name: CD38-negative IgG-negative class switched memory B cell
def: "A CD38-negative IgG-negative memory B cell is a IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-negative and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
is_a: CL:0002117 {is_inferred="true"} ! IgG-negative class switched memory B cell
intersection_of: CL:0002117 ! IgG-negative class switched memory B cell
intersection_of: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
relationship: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
[Term]
id: CL:0002119
name: CD38-positive IgG-negative class switched memory B cell
def: "A CD38-positive IgG-negative memory B cell is an IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-positive and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
is_a: CL:0002117 {is_inferred="true"} ! IgG-negative class switched memory B cell
intersection_of: CL:0002117 ! IgG-negative class switched memory B cell
intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
[Term]
id: CL:0002120
name: CD24-positive CD38-negative IgG-negative class switched memory B cell
def: "An CD24-positive CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-positive, CD38-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
is_a: CL:0002118 {is_inferred="true"} ! CD38-negative IgG-negative class switched memory B cell
intersection_of: CL:0002118 ! CD38-negative IgG-negative class switched memory B cell
intersection_of: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24
relationship: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24
[Term]
id: CL:0002121
name: CD24-negative CD38-negative IgG-negative class switched memory B cell
def: "A CD24-negative CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-negative, CD38-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
is_a: CL:0002118 {is_inferred="true"} ! CD38-negative IgG-negative class switched memory B cell
intersection_of: CL:0002118 ! CD38-negative IgG-negative class switched memory B cell
intersection_of: CL:4030046 PR:000001932 ! lacks_plasma_membrane_part signal transducer CD24
relationship: CL:4030046 PR:000001932 ! lacks_plasma_membrane_part signal transducer CD24
[Term]
id: CL:0002122
name: B220-positive CD38-positive IgG-negative class switched memory B cell
def: "A B220-positive CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-positive, CD38-positive, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
is_a: CL:0002119 {is_inferred="true"} ! CD38-positive IgG-negative class switched memory B cell
intersection_of: CL:0002119 ! CD38-positive IgG-negative class switched memory B cell
intersection_of: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
relationship: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
[Term]
id: CL:0002123
name: B220-low CD38-positive IgG-negative class switched memory B cell
def: "A B220-low CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-low, CD38-positive, and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131]
is_a: CL:0002122 ! B220-positive CD38-positive IgG-negative class switched memory B cell
intersection_of: CL:0002119 ! CD38-positive IgG-negative class switched memory B cell
intersection_of: RO:0015016 PR:000001014 ! has low plasma membrane amount receptor-type tyrosine-protein phosphatase C isoform CD45RABC
relationship: RO:0015016 PR:000001014 ! has low plasma membrane amount receptor-type tyrosine-protein phosphatase C isoform CD45RABC
[Term]
id: CL:0002132
name: stromal cell of ovary
def: "A stomal cell of the ovary" [GOC:tfm]
subset: cellxgene_subset
synonym: "ovarian stromal cell" EXACT [GOC:cjm]
xref: FMA:72299
is_a: CL:0000499 ! stromal cell
intersection_of: CL:0000499 ! stromal cell
intersection_of: part_of UBERON:0000992 ! ovary
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0000992 ! ovary
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002132" xsd:string {name="stromal cell of ovary on CELLxGENE CellGuide"}
creation_date: 2010-08-23T12:10:31Z
[Term]
id: CL:0002134
name: stromal cell of ovarian medulla
def: "A stromal cell of the ovarian medulla." [GOC:tfm]
xref: FMA:256171
is_a: CL:0002132 {is_inferred="true"} ! stromal cell of ovary
intersection_of: CL:0000499 ! stromal cell
intersection_of: part_of UBERON:0013192 ! ovarian medulla
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0013192 ! ovarian medulla
creation_date: 2010-08-23T12:12:17Z
[Term]
id: CL:0002136
name: type II cell of adrenal cortex
def: "A cell in the zona fasciculata that produce glucocorticoids, e.g cortisol." [GOC:tfm, ISBN:0517223651]
synonym: "type II cortical cell of adrenal gland" EXACT []
xref: FMA:69547
is_a: CL:0000460 ! glucocorticoid secreting cell
is_a: CL:0002097 ! cortical cell of adrenal gland
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-08-24T01:50:42Z
[Term]
id: CL:0002137
name: type III cell of adrenal cortex
def: "A cell in the zona reticularis that produce sex hormones." [GOC:tfm, ISBN:0517223651]
xref: FMA:69564
is_a: CL:0000593 ! androgen secreting cell
is_a: CL:0002097 ! cortical cell of adrenal gland
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-08-24T01:50:44Z
[Term]
id: CL:0002138
name: endothelial cell of lymphatic vessel
def: "A endothelial cell of a lymphatic vessel. The border of the oak leaf-shaped endothelial cell of initial lymphatics are joined by specialized buttons. The discontinuous feature of buttons distinguishes them from zippers in collecting lymphatics, but both types of junctions are composed of proteins typical of adherens junctions and tight junctions found in the endothelium of blood vessels. Buttons seal the sides of flaps of the oak leaf-shaped endothelial cell, leaving open the tips of flaps as routes for fluid entry without disassembly and reformation of intercellular junctions." [GOC:tfm, PMID:17846148]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "LEC" EXACT []
synonym: "lymphatic endothelial cell" EXACT []
xref: BTO:0004167
xref: FMA:68458
is_a: CL:0002139 {is_inferred="true"} ! endothelial cell of vascular tree
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0001473 ! lymphatic vessel
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0005022 ! vascular lymphangioblast
relationship: part_of UBERON:0001473 ! lymphatic vessel
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002138" xsd:string {name="endothelial cell of lymphatic vessel on CELLxGENE CellGuide"}
creation_date: 2010-08-24T02:05:28Z
[Term]
id: CL:0002139
name: endothelial cell of vascular tree
def: "An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels." [GOC:dsd, GOC:tfm, PMID:12768659]
comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, TAL1-positive.
subset: cellxgene_subset
synonym: "cubodial endothelial cell of vascular tree" NARROW []
synonym: "vascular endothelial cell" EXACT []
xref: BTO:0001854
xref: CALOHA:TS-1106
xref: FMA:67755
is_a: CL:0000115 ! endothelial cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002139" xsd:string {name="endothelial cell of vascular tree on CELLxGENE CellGuide"}
creation_date: 2010-08-24T02:06:40Z
[Term]
id: CL:0002140
name: skin sebocyte
def: "An acinar cell that is part of a skin sebaceous gland. This cell produces and secretes sebum into hair follicles." [GOC:tfm, PMID:37205445]
synonym: "acinar cell of sebaceous gland" BROAD []
synonym: "acinar cell of skin sebaceous gland" EXACT []
xref: BTO:0004613
xref: FMA:70953
is_a: CL:0000317 {is_inferred="true"} ! sebocyte
is_a: CL:0000622 ! acinar cell
intersection_of: CL:0000622 ! acinar cell
intersection_of: part_of UBERON:0003487 ! skin sebaceous gland
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0003487 ! skin sebaceous gland
creation_date: 2010-08-24T09:27:52Z
[Term]
id: CL:0002144
name: capillary endothelial cell
def: "An endothelial cell found in capillaries." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
xref: BTO:0004956
xref: CALOHA:TS-0112
xref: FMA:67756
is_a: CL:0002653 ! squamous endothelial cell
is_a: CL:2000008 ! microvascular endothelial cell
intersection_of: CL:0000071 ! blood vessel endothelial cell
intersection_of: part_of UBERON:0001915 ! endothelium of capillary
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001915 ! endothelium of capillary
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002144" xsd:string {name="capillary endothelial cell on CELLxGENE CellGuide"}
creation_date: 2010-08-24T10:15:00Z
[Term]
id: CL:0002145
name: multiciliated columnar cell of tracheobronchial tree
def: "A multi-ciliated epithelial cell located in the trachea and bronchi, characterized by a columnar shape and motile cilia on its apical surface. These cilia facilitate mucociliary clearance by moving mucus and trapped particles toward the pharynx." [GOC:tfm, PMID:28400610]
comment: The marker set C1orf194, MS4A8 can identify the Human cell type multiciliated columnar cell of tracheobronchial tree in the lung with a confidence of 0.86 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"}
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "ciliated columnar cell of tracheobronchial tree" EXACT []
xref: FMA:70542
is_a: CL:0002202 ! epithelial cell of tracheobronchial tree
is_a: CL:4030034 ! respiratory tract multiciliated cell
intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell
intersection_of: has_part GO:0031514 ! motile cilium
intersection_of: part_of UBERON:0008397 ! tracheobronchial epithelium
intersection_of: RO:0000053 PATO:0010007 ! has characteristic multiciliated
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002209 ! intermediate epitheliocyte
relationship: has_part GO:0031514 ! motile cilium
relationship: part_of UBERON:0008397 ! tracheobronchial epithelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0000053 PATO:0010007 ! has characteristic multiciliated
relationship: RO:0015004 CLM:1000041 ! has characterizing marker set
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002145" xsd:string {name="multiciliated columnar cell of tracheobronchial tree on CELLxGENE CellGuide"}
creation_date: 2010-08-24T03:38:29Z
[Term]
id: CL:0002148
name: dental pulp cell
def: "A cell found within the dental pulp." [GOC:tfm, PMID:36267574]
xref: CALOHA:TS-0195
xref: FMA:87170
is_a: CL:0002159 ! general ecto-epithelial cell
is_a: CL:0002320 ! connective tissue cell
intersection_of: CL:0002159 ! general ecto-epithelial cell
intersection_of: part_of UBERON:0001754 ! dental pulp
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001754 ! dental pulp
creation_date: 2010-08-24T02:52:09Z
[Term]
id: CL:0002149
name: epithelial cell of uterus
def: "An epithelial cell of the uterus. This cell has a mesodermal origin." [GOC:tfm, PMID:11331626, PMID:16960017, PMID:21698266]
subset: cellxgene_subset
xref: FMA:256161
is_a: CL:0002078 ! meso-epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0006955 ! uterine epithelium
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0006955 ! uterine epithelium
creation_date: 2010-08-24T10:45:54Z
[Term]
id: CL:0002152
name: columnar cell of endocervix
def: "A simple columnar epithelial cell located in the endocervix." [doi:/10.1016/j.autneu.2015.04.008, GOC:tfm, ISBN:0721662544]
xref: FMA:86486
is_a: CL:0000146 ! simple columnar epithelial cell
is_a: CL:0002535 ! epithelial cell of cervix
intersection_of: CL:0000146 ! simple columnar epithelial cell
intersection_of: part_of UBERON:0012252 ! endocervical epithelium
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0012252 ! endocervical epithelium
creation_date: 2010-08-24T10:47:47Z
[Term]
id: CL:0002153
name: corneocyte
def: "The dead keratin-filled squamous cell of the stratum corneum. This cell type lacks a nucleus." [GOC:tfm, ISBN:068340007X]
subset: human_reference_atlas
xref: BTO:0001943
xref: FMA:68650
is_a: CL:0000225 ! anucleate cell
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000311 ! keratin accumulating cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0000312 ! keratinocyte
relationship: part_of UBERON:0002027 ! stratum corneum of epidermis
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2010-08-24T10:53:03Z
[Term]
id: CL:0002159
name: general ecto-epithelial cell
def: "Epithelial cells derived from general body ectoderm and ectoderm placodes." [GOC:tfm]
xref: FMA:70556
is_a: CL:0002077 ! ecto-epithelial cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-08-26T08:31:08Z
[Term]
id: CL:0002166
name: epithelial cell of Malassez
def: "An epithelial cell that remains from the disintegration of the epithelial root sheath involved in the development of teeth." [GOC:tfm, ISBN:0517223651, ISBN:0815129521]
synonym: "epithelial cell rests of Malassez" EXACT []
synonym: "epithelial debris of Malassez" EXACT []
xref: FMA:62987
is_a: CL:0002159 {is_inferred="true"} ! general ecto-epithelial cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0011595 ! jaw region
creation_date: 2010-08-26T08:51:27Z
[Term]
id: CL:0002167
name: olfactory epithelial cell
def: "A specialized cell involved in sensory perception of smell." [GOC:tfm, PMID:7143026]
subset: cellxgene_subset
xref: FMA:67870
is_a: CL:0000098 ! sensory epithelial cell
is_a: CL:0000206 ! chemoreceptor cell
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:0002319 ! neural cell
is_a: CL:0002631 ! epithelial cell of upper respiratory tract
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001997 ! olfactory epithelium
relationship: capable_of GO:0050911 ! detection of chemical stimulus involved in sensory perception of smell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001997 ! olfactory epithelium
creation_date: 2010-08-26T01:47:13Z
[Term]
id: CL:0002169
name: basal cell of olfactory epithelium
def: "An epithelial cell located on the basal lamina of the olfactory epithelium." [GOC:tfm, PMID:7143026]
synonym: "horizontal basal cell" BROAD []
xref: FMA:62303
is_a: CL:0002167 {is_inferred="true"} ! olfactory epithelial cell
intersection_of: CL:0002167 ! olfactory epithelial cell
intersection_of: part_of UBERON:0000482 ! basal lamina of epithelium
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0000482 ! basal lamina of epithelium
creation_date: 2010-08-26T01:58:54Z
[Term]
id: CL:0002170
name: keratinized cell of the oral mucosa
def: "A keratinized cell located in the hard palate or gingiva." [GOC:tfm, PMID:12014572]
is_a: CL:0000237 ! keratinizing barrier epithelial cell
is_a: CL:0002336 ! buccal mucosa cell
intersection_of: CL:0000237 ! keratinizing barrier epithelial cell
intersection_of: part_of UBERON:0003729 ! mouth mucosa
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0003729 ! mouth mucosa
creation_date: 2010-08-26T02:51:30Z
[Term]
id: CL:0002173
name: extraglomerular mesangial cell
def: "A cell that is a specialized type of pericyte providing structural support for the capillary loops of kidney. A flat, elongated cell with extensive fine cytoplasmic processes found outside the kidney glomerulus near the macula densa and bound laterally by afferent and efferent arterioles. Being phagocytic, this cell participates in the continuous turnover of the basal lamina by removing its outer portion containing residues of filtration, while the lamina is renewed on its inner surface by the endothelial cells." [GOC:tfm, http:/www.copewithcytokines.de/cope.cgi?key=Lacis%20cells, ISBN:0412046911]
synonym: "Goormaghtigh cell" EXACT []
synonym: "lacis cell" RELATED []
synonym: "polar cushion cells" EXACT []
xref: FMA:84143
xref: KUPO:0001033
is_a: CL:0000650 ! mesangial cell
is_a: CL:1000618 {is_inferred="true"} ! juxtaglomerular complex cell
intersection_of: CL:0002320 ! connective tissue cell
intersection_of: part_of UBERON:0002321 ! extraglomerular mesangium
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002321 ! extraglomerular mesangium
creation_date: 2010-08-25T02:20:55Z
[Term]
id: CL:0002174
name: follicular cell of ovary
def: "A cell within the follicle of an ovary." [GOC:tfm]
xref: EMAPA:31247
xref: FMA:70589
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0001305 ! ovarian follicle
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: never_in_taxon NCBITaxon:50557 {source="https://github.com/obophenotype/cell-ontology/issues/589"} ! Insecta
relationship: part_of UBERON:0001305 ! ovarian follicle
creation_date: 2010-08-25T03:01:27Z
[Term]
id: CL:0002177
name: folliculostellate cell of pars distalis of adenohypophysis
def: "A supporting cell of the anterior pituitary gland involved in trophic and catabolic processes; expresses a broad spectrum of cytokeratins indicative of their epithelial nature." [GOC:tfm]
synonym: "folliculostellate cell of pars anterior of adenohypophysis" EXACT []
xref: FMA:83102
is_a: CL:0000642 {is_inferred="true"} ! folliculostellate cell
is_a: CL:0000710 ! neurecto-epithelial cell
intersection_of: CL:0000642 ! folliculostellate cell
intersection_of: part_of UBERON:0006964 ! pars distalis of adenohypophysis
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0006964 ! pars distalis of adenohypophysis
creation_date: 2010-08-25T03:10:10Z
[Term]
id: CL:0002178
name: epithelial cell of stomach
def: "An epithelial cell found in the lining of the stomach." [GOC:tfm]
subset: cellxgene_subset
xref: FMA:62948
is_a: CL:0002251 {is_inferred="true"} ! epithelial cell of alimentary canal
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001276 ! epithelium of stomach
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001276 ! epithelium of stomach
creation_date: 2010-08-25T03:22:08Z
[Term]
id: CL:0002180
name: mucous cell of stomach
def: "An epithelial cell of the stomach. This cell produces mucous." [GOC:tfm]
subset: cellxgene_subset
xref: FMA:63464
is_a: CL:0000319 ! mucus secreting cell
is_a: CL:0002178 ! epithelial cell of stomach
is_a: CL:1100001 ! secretory epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: capable_of GO:0070254 ! mucus secretion
intersection_of: part_of UBERON:0001276 ! epithelium of stomach
relationship: capable_of GO:0070254 ! mucus secretion
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001276 ! epithelium of stomach
creation_date: 2010-08-25T03:38:51Z
[Term]
id: CL:0002183
name: stem cell of gastric gland
def: "A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit." [GOC:tfm, ISBN:0517223651]
xref: FMA:62953
is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell
is_a: CL:0002178 ! epithelial cell of stomach
intersection_of: CL:0000048 ! multi fate stem cell
intersection_of: part_of UBERON:0000325 ! gastric gland
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0000325 ! gastric gland
creation_date: 2010-08-25T03:57:08Z
[Term]
id: CL:0002187
name: basal cell of epidermis
def: "A mitotically active, columnar-shaped keratinocyte located in the stratum basale of the epidermis and attached to the basement membrane. This cell exhibits heterogeneity, encompassing stem and progenitor subpopulations with distinct molecular and proliferative characteristics (Haensel et al., 2020), and serves as the primary source of new keratinocytes for epidermal renewal, homeostasis, and regeneration." [doi:/10.1073/pnas.1734203100, GOC:tfm, ISBN:0517223651, PMID:16824012, PMID:32187560, WIKIPEDIA:Basal_cell]
subset: cellxgene_subset
synonym: "epidermal basal cell" EXACT [PMID:32187560]
synonym: "epidermal basal keratinocyte" EXACT [PMID:7058342]
xref: FMA:70571
is_a: CL:0000646 ! basal cell
is_a: CL:0011026 ! progenitor cell
is_a: CL:1000428 ! stem cell of epidermis
is_a: CL:4052061 ! epidermal keratinocyte
intersection_of: CL:0000646 ! basal cell
intersection_of: part_of UBERON:0002025 ! stratum basale of epidermis
relationship: capable_of GO:0030216 ! keratinocyte differentiation
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002025 ! stratum basale of epidermis
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002187" xsd:string {name="basal cell of epidermis on CELLxGENE CellGuide"}
creation_date: 2010-08-26T03:12:49Z
[Term]
id: CL:0002188
name: glomerular endothelial cell
def: "An endothelial cell that is part of the glomerulus of the kidney. This cell is flattened, highly fenestrated, and plays a vital role in the formation of glomerular ultrafiltrate." [GOC:tfm, PMID:15840009]
comment: Glomerular endothelial cells have 60-80 nm fenestrations typically lacking diaphragms in adults but present during embryonic development. Some studies found diaphragms in 2-6% of mature rat glomerular capillaries. Their presence may depend on fixation techniques, developmental stage, or dynamic cell changes. Additionally, these cells help maintain the structural integrity of glomerular capillaries through interactions with the basement membrane and podocytes. {xref="PMID:33123011", xref="PMID:18480313", xref="PMID:19129259"}
subset: cellxgene_subset
subset: kidney_upper_slim
xref: BTO:0004632
xref: FMA:70970
is_a: CL:0000666 ! fenestrated endothelial cell
is_a: CL:0002681 ! kidney cortical cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0000074 ! renal glomerulus
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: has_part GO:0036053 ! glomerular endothelium fenestra
relationship: part_of UBERON:0000074 ! renal glomerulus
creation_date: 2010-08-26T10:59:44Z
[Term]
id: CL:0002191
name: granulocytopoietic cell
def: "A cell involved in the formation of a granulocyte." [GOC:tfm]
subset: cellxgene_subset
xref: FMA:83519
is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell
intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: capable_of GO:0030851 ! granulocyte differentiation
relationship: capable_of GO:0030851 ! granulocyte differentiation
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-08-30T12:54:27Z
[Term]
id: CL:0002194
name: monopoietic cell
def: "A cell involved in the formation of a monocyte (monopoiesis)." [GOC:tfm]
xref: FMA:83552
is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell
intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: capable_of GO:0030224 ! monocyte differentiation
relationship: capable_of GO:0030224 ! monocyte differentiation
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-08-30T01:27:48Z
[Term]
id: CL:0002195
name: hepatic stem cell
def: "A stem cell that can give rise to the cells of the liver. The term usually refers to the self-renewing pool of hepatocyte precursors in the adult liver (differently from 'hepatoblast', often used for fetal precursors of hepatocytes)." [GOC:tfm, PMID:26798363]
synonym: "HpSC" RELATED OMO:0003000 [PMID:18442648]
xref: FMA:86577
is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell
intersection_of: CL:0000048 ! multi fate stem cell
intersection_of: part_of UBERON:0002107 ! liver
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002107 ! liver
property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/800" xsd:string
creation_date: 2010-08-30T02:00:42Z
[Term]
id: CL:0002198
name: oncocyte
def: "A large epithelial cell with an extremely acidophilic and granular cytoplasm, containing vast numbers of mitochondria; such cells may undergo neoplastic transformation. From the Greek word onkos meaning swelling, this cell type is found in parathyroid, salivary and thyroid glands." [GOC:tfm, ISBN:0721662544, PMID:20013317]
synonym: "oxyphil" EXACT []
xref: FMA:67606
xref: MESH:D024862
is_a: CL:0002076 ! endo-epithelial cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-02T11:26:49Z
[Term]
id: CL:0002199
name: oxyphil cell of parathyroid gland
def: "An oncocyte located in the parathyroid gland." [PMID:20013317]
xref: FMA:69084
is_a: CL:0002198 ! oncocyte
is_a: CL:0002260 ! epithelial cell of parathyroid gland
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-02T11:33:23Z
[Term]
id: CL:0002200
name: oxyphil cell of thyroid
def: "An oncocyte located in the thyroid." [GOC:tfm, PMID:20013317]
synonym: "Askanazy cells" EXACT []
synonym: "Hurthle cells" EXACT []
xref: FMA:87169
is_a: CL:0002198 ! oncocyte
is_a: CL:0002257 ! epithelial cell of thyroid gland
intersection_of: CL:0002198 ! oncocyte
intersection_of: part_of UBERON:0002046 ! thyroid gland
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002046 ! thyroid gland
creation_date: 2010-09-02T11:33:26Z
[Term]
id: CL:0002202
name: epithelial cell of tracheobronchial tree
def: "An epithelial cell of the tracheobronchial tree." [GOC:tfm]
xref: FMA:66816
is_a: CL:0002632 ! epithelial cell of lower respiratory tract
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0008397 ! tracheobronchial epithelium
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0008397 ! tracheobronchial epithelium
creation_date: 2010-09-02T02:09:14Z
[Term]
id: CL:0002203
name: tuft cell of large intestine
def: "A tuft cell that is part of the epithelium of large intestine." [GOC:tfm, PMID:35271673]
comment: Brush cells are a distinct cell type from brush border cell-types.
subset: cellxgene_subset
synonym: "brush cell of epithelium proper of large intestine" EXACT []
synonym: "brush cell of large intestine" EXACT [http://orcid.org/0000-0003-4183-8865]
synonym: "tuft cell of epithelium of large intestine" EXACT [http://orcid.org/0000-0003-4183-8865]
xref: FMA:263222
is_a: CL:0002253 ! epithelial cell of large intestine
is_a: CL:0019032 ! intestinal tuft cell
intersection_of: CL:0002204 ! tuft cell
intersection_of: part_of UBERON:0001278 ! epithelium of large intestine
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001278 ! epithelium of large intestine
creation_date: 2010-09-02T02:20:50Z
[Term]
id: CL:0002204
name: tuft cell
def: "An epithelial cell found in various organs, including the gastrointestinal and respiratory tracts, characterized by a tuft of 120-140 blunt microvilli on its apical surface. This cell exhibits diverse functions depending on its location, which includes chemosensation, initiation of immune responses, contribution to mucociliary clearance, and defense against parasites." [GOC:tfm, ISBN:0517223651, PMID:15817800, PMID:30379593, PMID:36704202]
subset: cellxgene_subset
synonym: "brush cell" EXACT [PMID:36704202]
synonym: "caveolated cell" EXACT [PMID:36704202]
synonym: "fibrillovesicular cell" EXACT [PMID:36704202]
synonym: "multivesicular cell" EXACT [PMID:32307399]
synonym: "peculiar cell" EXACT [PMID:36704202]
xref: FMA:67978
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: has_part GO:0151001 ! tuft
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: has_part GO:0151001 ! tuft
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002204" xsd:string {name="tuft cell on CELLxGENE CellGuide"}
creation_date: 2010-09-02T02:28:53Z
[Term]
id: CL:0002205
name: brush cell of lobular bronchiole
def: "A brush cell found in the epithelium of lobular bronchiole." [GOC:tfm]
xref: FMA:263220
is_a: CL:0000082 ! epithelial cell of lung
is_a: CL:0002075 ! brush cell of tracheobronchial tree
intersection_of: CL:0002204 ! tuft cell
intersection_of: part_of UBERON:8600001 ! epithelium of lobular bronchiole
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:8600001 ! epithelium of lobular bronchiole
creation_date: 2010-09-02T02:38:34Z
[Term]
id: CL:0002206
name: brush cell of terminal bronchiole
def: "A brush cell of the epithelium in the terminal bronchiole." [GOC:tfm]
xref: FMA:263228
is_a: CL:0000082 ! epithelial cell of lung
is_a: CL:0002075 ! brush cell of tracheobronchial tree
intersection_of: CL:0002204 ! tuft cell
intersection_of: part_of UBERON:0001958 ! terminal bronchiole epithelium
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001958 ! terminal bronchiole epithelium
creation_date: 2010-09-02T02:38:36Z
[Term]
id: CL:0002207
name: brush cell of trachea
def: "Brush cell of the epithelium in the trachea." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
xref: FMA:263224
is_a: CL:0000307 {is_inferred="true"} ! tracheal epithelial cell
is_a: CL:0002075 {is_inferred="true"} ! brush cell of tracheobronchial tree
intersection_of: CL:0002204 ! tuft cell
intersection_of: part_of UBERON:0001901 ! epithelium of trachea
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001901 ! epithelium of trachea
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002207" xsd:string {name="brush cell of trachea on CELLxGENE CellGuide"}
creation_date: 2010-09-02T02:38:37Z
[Term]
id: CL:0002208
name: brush cell of bronchus
def: "A brush cell found in the epithelium of bronchus." [GOC:tfm]
subset: human_reference_atlas
xref: FMA:263226
is_a: CL:0002075 ! brush cell of tracheobronchial tree
is_a: CL:0002328 ! bronchial epithelial cell
intersection_of: CL:0002204 ! tuft cell
intersection_of: part_of UBERON:0002031 ! epithelium of bronchus
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002031 ! epithelium of bronchus
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002208" xsd:string {name="brush cell of bronchus on CELLxGENE CellGuide"}
creation_date: 2010-09-02T02:38:42Z
[Term]
id: CL:0002209
name: intermediate epitheliocyte
def: "An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells." [GOC:tfm, ISBN:0517223651]
synonym: "undifferentiated columnar cell of tracheobronchial tree" EXACT []
xref: FMA:69060
is_a: CL:0002202 ! epithelial cell of tracheobronchial tree
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-02T02:53:59Z
[Term]
id: CL:0002220
name: interstitial cell of pineal gland
def: "A cell located between the pinealocytes." [GOC:tfm, ISBN:0517223651]
xref: FMA:86575
is_a: CL:0000710 ! neurecto-epithelial cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-02T04:28:41Z
[Term]
id: CL:0002222
name: vertebrate lens cell
def: "A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye." [GOC:tfm, ISBN:0721662544]
subset: eye_upper_slim
xref: FMA:70950
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000306 ! crystallin accumulating cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0000965 ! lens of camera-type eye
creation_date: 2010-09-07T10:38:03Z
[Term]
id: CL:0002224
name: lens epithelial cell
def: "A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth." [GOC:tfm, http://en.wikipedia.org/wiki/Lens_%28anatomy%29#Lens_epithelium, ISBN:0721662544]
subset: cellxgene_subset
subset: human_reference_atlas
xref: FMA:67559
is_a: CL:0000075 {is_inferred="true"} ! columnar/cuboidal epithelial cell
is_a: CL:0002222 ! vertebrate lens cell
intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell
intersection_of: part_of UBERON:0001803 ! epithelium of lens
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001803 ! epithelium of lens
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002224" xsd:string {name="lens epithelial cell on CELLxGENE CellGuide"}
creation_date: 2010-09-07T10:45:47Z
[Term]
id: CL:0002231
name: epithelial cell of prostate
def: "An epithelial cell of the prostate." [GOC:tfm]
subset: cellxgene_subset
synonym: "prostate epithelial cell" EXACT []
xref: FMA:256163
xref: FMA:66817
is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell
intersection_of: CL:0002076 ! endo-epithelial cell
intersection_of: part_of UBERON:0002367 ! prostate gland
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002367 ! prostate gland
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002231" xsd:string {name="epithelial cell of prostate on CELLxGENE CellGuide"}
creation_date: 2010-09-07T01:49:29Z
[Term]
id: CL:0002232
name: epithelial cell of prostatic duct
def: "An epithelial cell of prostatic duct." [GOC:tfm]
synonym: "ductal epithelial cell of prostate" EXACT [FMA:74224]
xref: FMA:74224
is_a: CL:0000072 {is_inferred="true"} ! non-branched duct epithelial cell
is_a: CL:0002231 ! epithelial cell of prostate
intersection_of: CL:0000072 ! non-branched duct epithelial cell
intersection_of: part_of UBERON:0002485 ! prostate duct
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002485 ! prostate duct
creation_date: 2010-09-07T01:55:51Z
[Term]
id: CL:0002233
name: epithelial cell of prostatic acinus
def: "An epithelial cell of the prostatic acinus." [GOC:tfm, PMCID:PMC2673349]
synonym: "acinar epithelial cell of prostate" EXACT [FMA:74223]
xref: FMA:74223
is_a: CL:0002231 {is_inferred="true"} ! epithelial cell of prostate
intersection_of: CL:0002231 ! epithelial cell of prostate
intersection_of: part_of UBERON:0004179 ! prostate glandular acinus
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0004179 ! prostate glandular acinus
creation_date: 2010-09-07T01:55:53Z
[Term]
id: CL:0002234
name: basal cell of prostatic acinus
def: "A cell of the basal layer of the epithelium in the prostatic acinus." [GOC:tfm]
synonym: "basal epithelial cell of prostatic acinus" EXACT [FMA:74265]
xref: FMA:74265
is_a: CL:0002233 ! epithelial cell of prostatic acinus
is_a: CL:0002341 ! basal cell of prostate epithelium
intersection_of: CL:0002341 ! basal cell of prostate epithelium
intersection_of: part_of UBERON:0004179 ! prostate glandular acinus
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0004179 ! prostate glandular acinus
creation_date: 2010-09-07T01:59:08Z
[Term]
id: CL:0002236
name: basal epithelial cell of prostatic duct
def: "A cell that constitutes the basal layer of epithelium in the prostatic duct." [GOC:tfm, PMID:15226377]
subset: cellxgene_subset
xref: FMA:74226
is_a: CL:0000068 ! duct epithelial cell
is_a: CL:0002341 ! basal cell of prostate epithelium
intersection_of: CL:0002341 ! basal cell of prostate epithelium
intersection_of: part_of UBERON:0002485 ! prostate duct
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002485 ! prostate duct
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002236" xsd:string {name="basal epithelial cell of prostatic duct on CELLxGENE CellGuide"}
creation_date: 2010-09-07T01:59:12Z
[Term]
id: CL:0002240
name: marrow fibroblast
def: "A fibroblast in the bone marrow." [GOC:tfm]
xref: FMA:84377
is_a: CL:0000057 ! fibroblast
is_a: CL:0010001 ! stromal cell of bone marrow
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0002371 ! bone marrow
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002371 ! bone marrow
creation_date: 2010-09-07T02:25:18Z
[Term]
id: CL:0002241
name: pulmonary interstitial fibroblast
def: "A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis." [GOC:tfm]
comment: The marker set DPT, APOD can identify the Human cell type pulmonary interstitial fibroblast in the lung with a confidence of 0.58 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"}
subset: cellxgene_subset
synonym: "pulmonary myofibroblast" EXACT []
synonym: "pulmonary septal cell" EXACT []
xref: FMA:84467
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
is_a: CL:4030031 ! interstitial cell
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001004 ! respiratory system
intersection_of: part_of UBERON:0005169 ! interstitial tissue
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0005169 ! interstitial tissue
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0015004 CLM:1000046 ! has characterizing marker set
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002241" xsd:string {name="pulmonary interstitial fibroblast on CELLxGENE CellGuide"}
creation_date: 2010-09-07T02:29:38Z
[Term]
id: CL:0002242
name: nucleate cell
def: "A cell containing at least one nucleus." [GOC:tfm]
xref: FMA:67513
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0000053 PATO:0002505 ! has characteristic nucleated
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: RO:0000053 PATO:0002505 ! has characteristic nucleated
creation_date: 2010-09-07T03:32:33Z
[Term]
id: CL:0002243
name: smooth muscle cell of sphincter of pupil
def: "A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells." [GOC:tfm, ISBN:0721662544, ISBN:0721694128]
subset: cellxgene_subset
synonym: "smooth muscle fiber of sphincter of pupil" EXACT []
synonym: "smooth muscle fibre of sphincter of pupil" RELATED []
xref: FMA:70611
is_a: CL:0000358 {is_inferred="true"} ! sphincter associated smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0001607 ! sphincter pupillae
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0000133 ! neurectodermal cell
relationship: part_of UBERON:0001607 ! sphincter pupillae
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002243" xsd:string {name="smooth muscle cell of sphincter of pupil on CELLxGENE CellGuide"}
creation_date: 2010-09-08T08:53:42Z
[Term]
id: CL:0002244
name: squamous cell of ectocervix
def: "A stratified squamous epithelial cell located in the ectocervix." [doi:/10.1016/j.autneu.2015.04.008, GOC:tfm, http://www.bu.edu/histology/p/19404loa.htm, PMID:32644501]
synonym: "ectocervical squamous cell" EXACT []
xref: FMA:86483
is_a: CL:1001575 ! uterine cervix squamous cell
intersection_of: CL:0000076 ! squamous epithelial cell
intersection_of: part_of UBERON:0012251 ! ectocervical epithelium
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0012251 ! ectocervical epithelium
creation_date: 2010-09-08T09:12:23Z
[Term]
id: CL:0002246
name: peripheral blood stem cell
def: "A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells)." [GOC:tfm]
synonym: "PBSC" EXACT []
xref: BTO:0002669
xref: FMA:86711
xref: MESH:D000072916
is_a: CL:0000037 {is_inferred="true"} ! hematopoietic stem cell
is_a: CL:0000080 ! circulating cell
intersection_of: CL:0000037 ! hematopoietic stem cell
intersection_of: part_of UBERON:0000178 ! blood
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0000178 ! blood
creation_date: 2010-09-07T03:57:09Z
[Term]
id: CL:0002248
name: pluripotent stem cell
def: "A pluripotent stem cell has the ability to form cells from all three germ layers (ectoderm, mesoderm, and endoderm). However, unlike totipotent stem cells, they cell can not generate all the cells of the whole organism such as placenta." [GOC:tfm, PMID:19343304]
subset: cellxgene_subset
xref: FMA:70570
xref: MESH:D039904
is_a: CL:0000723 ! somatic stem cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-07T04:26:06Z
[Term]
id: CL:0002250
name: intestinal crypt stem cell
def: "A stem cell located in epithelium the based of the crypt of Lieberkuhn. Division of these cells serve both to maintain the stem cell population and produce the transit amplifying cells that are all precursors of all cell types that populate the intestinal epithelium." [GOC:tfm, ISBN:0517223651]
subset: cellxgene_subset
synonym: "stem cell of intestinal crypt of Lieberkuhn" EXACT []
xref: FMA:63379
is_a: CL:0000048 ! multi fate stem cell
is_a: CL:0002563 ! intestinal epithelial cell
intersection_of: CL:0000034 ! stem cell
intersection_of: part_of UBERON:0001983 ! crypt of Lieberkuhn
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001983 ! crypt of Lieberkuhn
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002250" xsd:string {name="intestinal crypt stem cell on CELLxGENE CellGuide"}
creation_date: 2010-09-08T09:21:22Z
[Term]
id: CL:0002251
name: epithelial cell of alimentary canal
def: "An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus." [GOC:tfm, ISBN:0721662544]
is_a: CL:0002076 ! endo-epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0003929 ! digestive tract epithelium
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0003929 ! digestive tract epithelium
creation_date: 2010-09-08T09:26:53Z
[Term]
id: CL:0002252
name: epithelial cell of esophagus
def: "An epithelial cell of the lining of the esophagus." [GOC:tfm]
subset: cellxgene_subset
xref: FMA:63071
xref: ZFA:0009400 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0002251 {is_inferred="true"} ! epithelial cell of alimentary canal
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001976 ! epithelium of esophagus
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001976 ! epithelium of esophagus
creation_date: 2010-09-08T09:28:20Z
[Term]
id: CL:0002253
name: epithelial cell of large intestine
def: "An epithelial cell of the lining of the large intestine." [GOC:tfm]
subset: cellxgene_subset
synonym: "epithelial cell of colon" RELATED []
xref: BTO:0004297
xref: FMA:256157
is_a: CL:0002563 {is_inferred="true"} ! intestinal epithelial cell
intersection_of: CL:0002563 ! intestinal epithelial cell
intersection_of: part_of UBERON:0000059 ! large intestine
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0001278 ! epithelium of large intestine
creation_date: 2010-09-08T09:28:22Z
[Term]
id: CL:0002254
name: epithelial cell of small intestine
def: "An epithelial cell of the lining of the small intestine." [GOC:tfm]
subset: cellxgene_subset
xref: FMA:256159
is_a: CL:0002563 {is_inferred="true"} ! intestinal epithelial cell
intersection_of: CL:0002563 ! intestinal epithelial cell
intersection_of: part_of UBERON:0002108 ! small intestine
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002108 ! small intestine
creation_date: 2010-09-08T09:41:46Z
[Term]
id: CL:0002255
name: stromal cell of endometrium
def: "A stromal cell of the endometrium, characterized by its fibroblast-like morphology, regenerative capacity, and ability to undergo decidualization. It differentiates into a decidual stromal cell during pregnancy, essential for embryo implantation and maintenance. This cell is involved in tissue proliferation, remodeling, and breakdown, responding to hormonal changes, particularly estrogen and progesterone." [https://doi.org/10.1038/s41591-020-1040-z, PMID:11331626, PMID:30013421, PMID:30309298, PMID:31907034, Wikipedia:Decidualization]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "endometrial stromal cell" EXACT []
synonym: "endometrial stromal fibroblast" EXACT [PMID:30309298]
synonym: "stromal cell of uterus" BROAD []
xref: CALOHA:TS-1266
xref: FMA:86490
is_a: CL:0000499 ! stromal cell
intersection_of: CL:0000499 ! stromal cell
intersection_of: part_of UBERON:0002337 ! endometrial stroma
relationship: capable_of GO:0046697 ! decidualization
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002337 ! endometrial stroma
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002388 CL:2000002 ! has potential to directly develop into decidual cell
creation_date: 2010-09-08T09:50:04Z
[Term]
id: CL:0002256
name: supporting cell of carotid body
def: "A supportive cell that has characteristics of glial cell. Processes of this cell envelope the junctions between glomus cells and nerve endings." [GOC:tfm, http://www.copewithcytokines.de/cope.cgi?key=glomus%20cells, PMID:8985136]
synonym: "carotid body sustentacular cell" EXACT []
xref: FMA:84188
is_a: CL:0000630 ! supporting cell
is_a: CL:0000710 ! neurecto-epithelial cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-08T10:34:45Z
[Term]
id: CL:0002257
name: epithelial cell of thyroid gland
def: "An epithelial cell of thyroid gland." [GOC:tfm]
subset: cellxgene_subset
xref: FMA:256167
xref: MESH:D000072637
is_a: CL:0000150 ! glandular secretory epithelial cell
is_a: CL:0002076 ! endo-epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0002046 ! thyroid gland
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002046 ! thyroid gland
creation_date: 2010-09-08T01:46:51Z
[Term]
id: CL:0002258
name: thyroid follicular cell
def: "An epithelial cell that is part of the thyroid follicle epithelium, with a shape that ranges from squamous when inactive to cuboidal or columnar when active, reflecting its hormonal activity. Its apical surface is lined with microvilli projecting into the colloid-filled lumen, where it synthesizes, stores, and secretes the thyroid hormones thyroxine (T4) and triiodothyronine (T3), releasing them into the bloodstream in response to thyroid-stimulating hormone (TSH)." [GOC:tfm, ISBN:0517223651, PMID:31869123]
subset: cellxgene_subset
synonym: "follicular cell of thyroid gland" EXACT []
synonym: "principal cell of thyroid gland" EXACT []
synonym: "thyroid gland follicular cell" EXACT []
synonym: "thyroid hormone secreting cell" EXACT []
xref: BTO:0003736
xref: CALOHA:TS-1285
xref: FMA:68782
is_a: CL:0000163 ! endocrine cell
is_a: CL:0000167 ! peptide hormone secreting cell
is_a: CL:0002257 ! epithelial cell of thyroid gland
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: has_part GO:0005902 ! microvillus
relationship: part_of UBERON:0012363 ! thyroid follicle epithelium
creation_date: 2010-09-08T01:50:08Z
[Term]
id: CL:0002260
name: epithelial cell of parathyroid gland
def: "An epithelial cell of the parathyroid gland." [GOC:tfm]
subset: cellxgene_subset
xref: FMA:70547
is_a: CL:0002076 ! endo-epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001132 ! parathyroid gland
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001132 ! parathyroid gland
creation_date: 2010-09-08T02:29:38Z
[Term]
id: CL:0002261
name: endothelial cell of viscerocranial mucosa
def: "An endothelial cell found in the mucosa associated with the facial skeleton." [GOC:tfm, ISBN:0618947256]
xref: FMA:70627
is_a: CL:0002076 ! endo-epithelial cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-14T10:40:12Z
[Term]
id: CL:0002262
name: endothelial cell of sinusoid
def: "An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver." [GOC:tfm, ISBN:0618947256]
subset: cellxgene_subset
subset: human_reference_atlas
xref: FMA:63134
is_a: CL:0000071 ! blood vessel endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0003909 ! sinusoid
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0003909 ! sinusoid
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002262" xsd:string {name="endothelial cell of sinusoid on CELLxGENE CellGuide"}
creation_date: 2010-09-14T10:57:26Z
[Term]
id: CL:0002264
name: type A cell of stomach
def: "A type of enteroendocrine cell found in the stomach that secretes glucagon." [GOC:tfm]
xref: FMA:83411
is_a: CL:0002067 ! type A enteroendocrine cell
is_a: CL:1001517 ! stomach enteroendocrine cell
intersection_of: CL:0002067 ! type A enteroendocrine cell
intersection_of: part_of UBERON:0001276 ! epithelium of stomach
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001276 ! epithelium of stomach
creation_date: 2010-09-10T10:54:42Z
[Term]
id: CL:0002265
name: type D cell of colon
def: "A D cell located in the colon." [GOC:tfm]
synonym: "colon D-cell" EXACT []
synonym: "colonic delta cell" EXACT []
synonym: "delta cell of colon" EXACT []
xref: FMA:268744
is_a: CL:0000502 ! type D enteroendocrine cell
is_a: CL:0009042 ! enteroendocrine cell of colon
is_a: CL:1001588 ! colon glandular cell
intersection_of: CL:0000502 ! type D enteroendocrine cell
intersection_of: part_of UBERON:0001155 ! colon
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: part_of UBERON:0001155 ! colon
creation_date: 2010-09-10T11:37:35Z
[Term]
id: CL:0002266
name: type D cell of small intestine
def: "A type D cell of the small intestine." [GOC:tfm]
synonym: "delta cell of small intestine" EXACT []
synonym: "small intestine D-cell" EXACT []
synonym: "small intestine delta cell" EXACT []
xref: FMA:268736
is_a: CL:0000502 ! type D enteroendocrine cell
is_a: CL:0009006 ! enteroendocrine cell of small intestine
intersection_of: CL:0000502 ! type D enteroendocrine cell
intersection_of: part_of UBERON:0002108 ! small intestine
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: part_of UBERON:0002108 ! small intestine
creation_date: 2010-09-10T01:34:22Z
[Term]
id: CL:0002267
name: type D cell of stomach
def: "A type D cell found in the stomach." [GOC:tfm]
synonym: "delta cell of stomach" EXACT []
synonym: "stomach D-cell" EXACT []
synonym: "stomach delta cell" EXACT []
xref: FMA:83410
is_a: CL:0000502 ! type D enteroendocrine cell
is_a: CL:0002659 ! glandular epithelial cell of stomach
is_a: CL:1000222 ! stomach neuroendocrine cell
intersection_of: CL:0000502 ! type D enteroendocrine cell
intersection_of: part_of UBERON:0001276 ! epithelium of stomach
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001276 ! epithelium of stomach
creation_date: 2010-09-10T01:36:03Z
[Term]
id: CL:0002274
name: histamine secreting cell
def: "A cell type that secretes histamine." [GOC:tfm]
is_a: CL:0000457 ! biogenic amine secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0001821 ! histamine secretion
relationship: capable_of GO:0001821 ! histamine secretion
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-10T03:04:42Z
[Term]
id: CL:0002275
name: pancreatic PP cell
def: "A PP cell located in the islets of the pancreas." [GOC:tfm]
comment: The term PP cell of pancreatic acinus was obsoleted due to a lack of evidence, making PP cell of pancreatic islets synonymous with pancreatic PP cell.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "pancreatic polypeptide-secreting cell" EXACT []
synonym: "PP cell of pancreatic islet" EXACT []
synonym: "PP-cell of pancreatic islet" EXACT []
xref: BTO:0000805
xref: FMA:70588
xref: MESH:D050418
xref: ZFA:0005742 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000696 ! PP cell
is_a: CL:0008024 ! pancreatic endocrine cell
intersection_of: CL:0000696 ! PP cell
intersection_of: part_of UBERON:0000006 ! islet of Langerhans
intersection_of: part_of UBERON:0001264 ! pancreas
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0000006 ! islet of Langerhans
relationship: part_of UBERON:0001264 ! pancreas
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002275" xsd:string {name="pancreatic PP cell on CELLxGENE CellGuide"}
creation_date: 2010-09-10T03:30:31Z
[Term]
id: CL:0002292
name: type I cell of carotid body
def: "A round or oval neuroepithelial cell that contacts other type I cells or capillaries. They occur in clusters that are surrounded by sheath cells (type-II cells) in the carotid body. This cell type is capable of secreting a number of neurotransmitters." [GOC:tfm, ISBN:0517223651]
subset: human_reference_atlas
synonym: "glomus cell" EXACT []
xref: FMA:84186
is_a: CL:0000710 ! neurecto-epithelial cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2010-09-13T01:40:21Z
[Term]
id: CL:0002293
name: epithelial cell of thymus
def: "An epithelial cell of the thymus. Epithelial reticular cells are pleomorphic, stellate, non-phagocytic cells which seem to be supportive in function and are held together by desmosomes. They replace the fibroblastoid reticular cells found in other lymphoid organs. Other epithelial cells in the medulla have the ultrastructure of secretory cells. Although different epithelial cells throughout the thymus appear alike by light microscopy their ultrastructure and function varies." [FMA:72208, GOC:tfm]
subset: cellxgene_subset
synonym: "epithelial cell of thymus gland" EXACT []
synonym: "epithelial reticular cell" EXACT []
synonym: "epithelial reticular cell of thymus" EXACT []
synonym: "thymic epithelial cell" EXACT []
xref: CALOHA:TS-1040
xref: FMA:72208
is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell
intersection_of: CL:0002076 ! endo-epithelial cell
intersection_of: part_of UBERON:0002370 ! thymus
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002370 ! thymus
creation_date: 2010-09-13T02:34:22Z
[Term]
id: CL:0002294
name: type-1 epithelial cell of thymus
def: "An epithelial cell with a well defined Golgi apparatus that makes up the continuous layer of cells bordering the thymic tissue beneath the capsule." [GOC:tfm, PMID:9264335]
synonym: "subcapsular thymic epithelial cell" RELATED [PMID:18194204, PMID:2694455]
xref: FMA:72209
is_a: CL:0002364 ! cortical thymic epithelial cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-13T02:37:23Z
[Term]
id: CL:0002301
name: type B synovial cell
def: "A resident stromal cell located in the synovial membrane and responsible for the production of immune-related cytokines and chemokines. This cell type secretes glycoproteins and hyaluronic acid, has abundant granular endoplasmic reticulum, but contains fewer vacuoles and vesicles." [GOC:tfm, ISBN:0517223651, PMID:34433485, PMID:34772990]
comment: Type B synovial cells play a key role in the pathogenesis of chronic inflammatory diseases, such as rheumatoid arthritis, and are essential for the maintenance of normal joint functions. Fibroblast-like synoviocytes from different joints have different properties, which may contribute to the characteristic pattern of joint involvement in different types of arthritis. {xref="https://en.wikipedia.org/wiki/Fibroblast-like_synoviocyte", xref="PMID:34433485"}
synonym: "fibroblast-like synoviocyte" EXACT []
synonym: "synovial fibroblast" EXACT [PMID:23147896]
xref: BTO:0003652
xref: FMA:66788
is_a: CL:0000214 ! synovial cell
is_a: CL:0000499 ! stromal cell
intersection_of: CL:0000499 ! stromal cell
intersection_of: part_of UBERON:0002018 ! synovial membrane of synovial joint
relationship: capable_of GO:0030213 ! hyaluronan biosynthetic process
relationship: dc-contributor https://orcid.org/0000-0002-0819-0473
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002018 ! synovial membrane of synovial joint
relationship: produces UBERON:0001090 ! synovial fluid
creation_date: 2010-09-13T03:39:14Z
[Term]
id: CL:0002305
name: epithelial cell of distal tubule
def: "An epithelial cell of the distal convoluted tubule of the kidney that helps regulate systemic levels of potassium, sodium, calcium, and pH." [GOC:tfm, ISBN:0517223651]
subset: cellxgene_subset
subset: kidney_upper_slim
synonym: "kidney distal tubule epithelial cell" EXACT []
xref: FMA:70981
xref: KUPO:0001055
is_a: CL:0002078 ! meso-epithelial cell
is_a: CL:1000494 {is_inferred="true"} ! nephron tubule epithelial cell
is_a: CL:1000615 ! kidney cortex tubule cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0004135 ! distal tubule
relationship: part_of UBERON:0004135 ! distal tubule
[Term]
id: CL:0002306
name: epithelial cell of proximal tubule
def: "An epithelial cell of the proximal tubule of the kidney." [GOC:tfm, ISBN:1-4160-2328-3]
comment: The vast majority of proximal tubule epithelial cells have a brush border, but there are rare exceptions.
subset: cellxgene_subset
subset: human_reference_atlas
subset: kidney_upper_slim
synonym: "kidney proximal tubule epithelial cell" EXACT []
xref: FMA:70973
xref: KUPO:0001044
is_a: CL:0002078 ! meso-epithelial cell
is_a: CL:1000494 {is_inferred="true"} ! nephron tubule epithelial cell
is_a: CL:1000615 ! kidney cortex tubule cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0004134 ! proximal tubule
relationship: part_of UBERON:0004134 ! proximal tubule
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002306" xsd:string {name="epithelial cell of proximal tubule on CELLxGENE CellGuide"}
[Term]
id: CL:0002307
name: brush border cell of the proximal tubule
def: "A brush border epithelial cell located in the proximal tubule of the kidney, essential for reabsorbing substances like glucose and amino acids from the glomerular filtrate. These cells also secrete organic ions, playing a crucial role in maintaining kidney homeostasis, including electrolyte and acid-base balance, and excreting metabolic waste." [GOC:tfm, ISBN:1-4160-2328-3, PMID:23799132]
comment: The vast majority of proximal tubule epithelial cells have a brush border, but there are rare exceptions.
is_a: CL:0000239 ! brush border epithelial cell
is_a: CL:0002306 ! epithelial cell of proximal tubule
intersection_of: CL:0002306 ! epithelial cell of proximal tubule
intersection_of: has_part GO:0005903 ! brush border
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: has_part GO:0005903 ! brush border
creation_date: 2010-09-14T11:29:20Z
[Term]
id: CL:0002308
name: epithelial cell of skin gland
def: "An epithelial cell of a skin gland." [GOC:tfm]
synonym: "epithelial cell of gland of skin" EXACT []
xref: FMA:70657
is_a: CL:0002159 ! general ecto-epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0002419 ! skin gland
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002419 ! skin gland
creation_date: 2010-09-14T12:00:07Z
[Term]
id: CL:0002312
name: somatotroph
def: "An acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [SANBI:mhl]
synonym: "somatotrope" EXACT []
synonym: "somatotropic cell" EXACT []
synonym: "somatrophic cell" EXACT []
xref: FMA:83095
xref: MESH:D052683
is_a: CL:0000295 ! somatotropin secreting cell
is_a: CL:0000638 ! acidophil cell of pars distalis of adenohypophysis
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-14T02:33:09Z
[Term]
id: CL:0002313
name: endocrine-paracrine cell of prostate gland
def: "An ecto-epithelial cell of the prostate gland that secretes hormones." [GOC:tfm]
synonym: "glandular cell of prostate" EXACT []
synonym: "neuro-epithelial cell of prostate gland" EXACT []
xref: CALOHA:TS-1280
xref: FMA:74390
xref: FMA:86774
is_a: CL:0000150 ! glandular secretory epithelial cell
is_a: CL:0002159 ! general ecto-epithelial cell
intersection_of: CL:0002159 ! general ecto-epithelial cell
intersection_of: capable_of GO:0046879 ! hormone secretion
intersection_of: part_of UBERON:0002367 ! prostate gland
relationship: capable_of GO:0046879 ! hormone secretion
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002367 ! prostate gland
creation_date: 2010-09-14T03:01:58Z
[Term]
id: CL:0002315
name: supporting cell of cochlea
def: "An epithelial supporting cell located in the cochlea." [GOC:tfm]
xref: FMA:79796
is_a: CL:0001035 ! bone cell
is_a: CL:0005014 ! auditory epithelial supporting cell
intersection_of: CL:0005014 ! auditory epithelial supporting cell
intersection_of: part_of UBERON:0001844 ! cochlea
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001844 ! cochlea
creation_date: 2010-09-14T03:31:38Z
[Term]
id: CL:0002316
name: supporting cell of vestibular epithelium
def: "A supporting cell of the vestibular epithelium." [GOC:tfm, PMID:20837532]
subset: cellxgene_subset
xref: FMA:75607
is_a: CL:0005014 ! auditory epithelial supporting cell
intersection_of: CL:0005014 ! auditory epithelial supporting cell
intersection_of: part_of UBERON:0001862 ! vestibular labyrinth
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001862 ! vestibular labyrinth
creation_date: 2010-09-14T03:31:44Z
[Term]
id: CL:0002319
name: neural cell
def: "A cell that is part of the nervous system." [GOC:tfm, ISBN:0618947256]
subset: cellxgene_subset
subset: general_cell_types_upper_slim
xref: CALOHA:TS-2040
xref: FMA:70333
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0001016 ! nervous system
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001016 ! nervous system
creation_date: 2010-09-15T01:34:57Z
[Term]
id: CL:0002320
name: connective tissue cell
def: "A cell of the supporting or framework tissue of the body, which includes adipose tissue, cartilage, and bone. In vertebrates, this cell arises chiefly from the embryonic mesoderm and, in cranial regions, from neural crest." [GOC:tfm, ISBN:0618947256, PMID:19198652, PMID:26043871, PMID:31194383]
subset: cellxgene_subset
subset: general_cell_types_upper_slim
xref: CALOHA:TS-2096
xref: FMA:63875
xref: MESH:D003239
xref: ZFA:0009392 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0002384 ! connective tissue
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002384 ! connective tissue
creation_date: 2010-09-15T03:01:54Z
[Term]
id: CL:0002321
name: embryonic cell (metazoa)
def: "A cell of the embryo." [FMA:0618947256]
xref: CALOHA:TS-0263
xref: FMA:82840
xref: WBbt:0007028
xref: ZFA:0007089 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000000 ! cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002321" xsd:string {name="embryonic cell (metazoa) on CELLxGENE CellGuide"}
creation_date: 2010-09-15T03:39:21Z
[Term]
id: CL:0002323
name: amniocyte
def: "A cell of a fetus which is suspended in the amniotic fluid. Amniocytes are considered to arise from several tissues including fetal skin, the fetal urinary tract, umbilical cord, and the inner amniotic surface." [BFO:0000066, GOC:tfm, PMID:3211847]
xref: BTO:0000066
is_a: CL:0000349 {is_inferred="true"} ! extraembryonic cell
intersection_of: CL:0000349 ! extraembryonic cell
intersection_of: located_in UBERON:0000173 ! amniotic fluid
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: located_in UBERON:0000173 ! amniotic fluid
creation_date: 2010-09-20T10:13:37Z
[Term]
id: CL:0002324
name: basal-myoepithelial cell of mammary gland
def: "A myoepithelial cell that is part of a mammary gland and is located in the basal layer. During lactation, a basal-myoepithelial cell of mammary gland contracts under the stimulation of oxytocin. In humans, a basal-myoepithelial cell of mammary gland can be identified by high levels of CD49f and low levels of EpCAM." [GOC:tfm, PMID:11250738, PMID:19022771, PMID:38059556]
comment: Due inconsistencies in naming this and other mammary gland epithelial cell types, several mammary gland experts gathered for a breast atlas annotation jamboree organized by Chan-Zuckerberg initiative. They agreed to label this cell type as basal-myoepithelial cell (and abbreviated: B-Myo cell). {xref="PMID:38059556"}
subset: cellxgene_subset
synonym: "B-Myo cell" RELATED OMO:0003000 []
synonym: "basal" RELATED OMO:0003000 [PMID:37380767]
synonym: "basal cell of lactiferous duct" NARROW [FMA:67800]
synonym: "basal myoepithelial cell" BROAD [PMID:37694522]
synonym: "basal-myoepithelial cell" BROAD [PMID:37380767]
synonym: "BM" RELATED OMO:0003000 [PMID:38059556]
synonym: "myoepithelial cell of lactiferous gland" NARROW []
synonym: "myoepithelial cell of mammary gland" EXACT [PMID:11250738]
xref: CALOHA:TS-2378
xref: FMA:67800
is_a: CL:0000185 ! myoepithelial cell
is_a: CL:0002327 ! mammary gland epithelial cell
intersection_of: CL:0000185 ! myoepithelial cell
intersection_of: part_of UBERON:0001911 ! mammary gland
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: dc-contributor https://orcid.org/0000-0003-4969-670X
relationship: part_of UBERON:0001911 ! mammary gland
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002324" xsd:string {name="basal-myoepithelial cell of mammary gland on CELLxGENE CellGuide"}
creation_date: 2010-09-20T11:42:14Z
[Term]
id: CL:0002325
name: lactocyte
def: "A milk-producing glandular epithelial cell that is part of a mammary gland alveolus and differentiates from a luminal adaptive secretory precursor cell during secretory differentiation (also termed lactogenesis I). Following secretory activation (also termed lactogenesis II), a lactocyte is involved in the synthesis and/or transport of milk constituents including proteins, oligosaccharides, lactose, micronutrients, fat, hormones, immunoglobulins, and cytokines into the lumen of the lactating mammary gland." [doi:10.1177/156482659601700404, GOC:tfm, PMID:19022771, PMID:28717367, PMID:35091553, PMID:35377806]
subset: cellxgene_subset
synonym: "epithelial cell of lactiferous gland" EXACT []
synonym: "lactaction-associated mammary epithelial cell" EXACT [PMID:35091553]
synonym: "lactation-derived mammary cell" EXACT [PMID:35091553]
synonym: "LMC" RELATED OMO:0003000 [PMID:35091553]
synonym: "luminal cell of alveolus of lactiferous gland" EXACT []
synonym: "mammary alveolar cell" BROAD [PMID:19022771]
synonym: "mammary alveolar epithelial cell" EXACT []
synonym: "mammary gland alveolar epithelial cell" EXACT []
xref: FMA:74506
xref: FMA:79866
is_a: CL:0000314 ! milk secreting cell
is_a: CL:0002159 {is_inferred="true"} ! general ecto-epithelial cell
is_a: CL:1001586 ! mammary gland glandular cell
intersection_of: CL:0000150 ! glandular secretory epithelial cell
intersection_of: part_of UBERON:0003214 ! mammary gland alveolus
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: dc-contributor https://orcid.org/0000-0003-4361-817X
relationship: develops_from CL:4033057 ! luminal adaptive secretory precursor cell of mammary gland
relationship: part_of UBERON:0003214 ! mammary gland alveolus
creation_date: 2010-09-20T01:30:57Z
[Term]
id: CL:0002326
name: luminal epithelial cell of mammary gland
def: "A mammary epithelial cell that occurs in the lumen of the ductal and alveoli structure in the breast." [GOC:tfm, PMID:19022771]
subset: cellxgene_subset
synonym: "mature luminal cell" BROAD [PMID:21930782]
xref: FMA:73280
is_a: CL:0000069 ! branched duct epithelial cell
is_a: CL:0002327 ! mammary gland epithelial cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0009116 ! progenitor cell of mammary luminal epithelium
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002326" xsd:string {name="luminal epithelial cell of mammary gland on CELLxGENE CellGuide"}
creation_date: 2010-09-20T01:37:53Z
[Term]
id: CL:0002327
name: mammary gland epithelial cell
def: "An epithelial cell of the mammary gland." [GOC:tfm, PMID:19022771]
subset: cellxgene_subset
synonym: "breast epithelial cell" EXACT []
synonym: "mammary epithelial cell" EXACT []
xref: BTO:0004300
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001911 ! mammary gland
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001911 ! mammary gland
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002327" xsd:string {name="mammary gland epithelial cell on CELLxGENE CellGuide"}
creation_date: 2010-09-20T01:49:37Z
[Term]
id: CL:0002328
name: bronchial epithelial cell
def: "An epithelial cell of the bronchus." [GOC:tfm]
subset: cellxgene_subset
xref: BTO:0002922
is_a: CL:0002202 ! epithelial cell of tracheobronchial tree
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0002185 ! bronchus
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002031 ! epithelium of bronchus
relationship: part_of UBERON:0002185 ! bronchus
creation_date: 2010-09-20T02:00:00Z
[Term]
id: CL:0002329
name: basal epithelial cell of tracheobronchial tree
def: "An epithelial cell type that lacks the columnar shape typical for other respiratory epithelial cells. This cell type is able to differentiate into other respiratory epithelial cells in response to injury." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:0002202 ! epithelial cell of tracheobronchial tree
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002329" xsd:string {name="basal epithelial cell of tracheobronchial tree on CELLxGENE CellGuide"}
creation_date: 2010-09-20T02:10:36Z
[Term]
id: CL:0002332
name: multiciliated epithelial cell of the bronchus
def: "A multi-ciliated epithelial cell located in the bronchus epithelium, characterized by a columnar shape and motile cilia on its apical surface." [GOC:tfm, PMID:18757316]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "ciliated epithelial cell of the bronchus" EXACT []
is_a: CL:0002145 ! multiciliated columnar cell of tracheobronchial tree
is_a: CL:0002328 ! bronchial epithelial cell
intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell
intersection_of: has_part GO:0031514 ! motile cilium
intersection_of: part_of UBERON:0002031 ! epithelium of bronchus
intersection_of: RO:0000053 PATO:0010007 ! has characteristic multiciliated
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: has_part GO:0031514 ! motile cilium
relationship: part_of UBERON:0002031 ! epithelium of bronchus
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0000053 PATO:0010007 ! has characteristic multiciliated
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002332" xsd:string {name="multiciliated epithelial cell of the bronchus on CELLxGENE CellGuide"}
creation_date: 2010-09-20T02:21:12Z
[Term]
id: CL:0002333
name: neural crest derived adipocyte
def: "An adipocyte derived from a neural crest cell." [GOC:tfm, PMID:17507398]
is_a: CL:0000136 ! adipocyte
intersection_of: CL:0000136 ! adipocyte
intersection_of: develops_from CL:0000333 ! migratory neural crest cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0000005 ! neural crest derived fibroblast
relationship: develops_from CL:0000333 ! migratory neural crest cell
creation_date: 2010-09-20T02:25:25Z
[Term]
id: CL:0002334
name: preadipocyte
def: "An undifferentiated fibroblast that can be stimulated to form a fat cell." [GOC:tfm, PMID:18793119]
subset: cellxgene_subset
xref: BTO:0001107
is_a: CL:0000057 ! fibroblast
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002334" xsd:string {name="preadipocyte on CELLxGENE CellGuide"}
creation_date: 2010-09-20T02:31:53Z
[Term]
id: CL:0002335
name: brown preadipocyte
def: "A preadipocyte that is capable of differentiating into a brown adipocyte. This cell type expresses uncoupling protein-1, PPAR-gamma, PR-domain-containing 16; and PGC-1alpha (peroxisome proliferator-activated receptor-gamma (PPARgamma) coactivator-1alpha)." [GOC:tfm, PMID:18719589]
subset: cellxgene_subset
is_a: CL:0002334 ! preadipocyte
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002335" xsd:string {name="brown preadipocyte on CELLxGENE CellGuide"}
creation_date: 2010-09-20T02:38:38Z
[Term]
id: CL:0002336
name: buccal mucosa cell
def: "An endothelial cell that lines the oral cavitiy including the mucosa of the gums, the palate, the lip, and the cheek." [GOC:tfm, MESH:D009061]
is_a: CL:0002261 ! endothelial cell of viscerocranial mucosa
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-20T02:52:54Z
[Term]
id: CL:0002338
name: CD56-positive, CD161-positive immature natural killer cell, human
def: "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-positive, CD117-positive, CD122-positive,and CD161-positive." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12457618]
comment: Human markers; killer cell immunoglobulin-like receptor 2DL1 is used as a representative example (PRO at this time lacks a KIR superfamily).
subset: cellxgene_subset
synonym: "p-NK" RELATED [PMID:12457618]
is_a: CL:0000823 ! immature natural killer cell
intersection_of: CL:0000823 ! immature natural killer cell
intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule
intersection_of: in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: RO:0002104 PR:000001024 ! has plasma membrane part neural cell adhesion molecule 1
intersection_of: RO:0002104 PR:000001381 ! has plasma membrane part interleukin-2 receptor subunit beta
intersection_of: RO:0002104 PR:000001874 ! has plasma membrane part KLRB1-like protein
intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor
relationship: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002344 ! CD56-negative, CD161-positive immature natural killer cell, human
relationship: in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 PR:000001024 ! has plasma membrane part neural cell adhesion molecule 1
relationship: RO:0002104 PR:000001381 ! has plasma membrane part interleukin-2 receptor subunit beta
relationship: RO:0002104 PR:000001874 ! has plasma membrane part KLRB1-like protein
relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor
creation_date: 2010-09-21T10:06:53Z
[Term]
id: CL:0002339
name: prostate stem cell
def: "A prostate epithelial cell that is CD133-positive, CD44-positive, integrin A2beta3-high. This cell is a stem cell for the prostate epithelium." [GOC:tfm, PMID:15226377]
synonym: "CD133-positive prostate epithelial cell" EXACT []
is_a: CL:0000048 ! multi fate stem cell
is_a: CL:0002341 ! basal cell of prostate epithelium
intersection_of: CL:0000034 ! stem cell
intersection_of: part_of UBERON:0002367 ! prostate gland
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002367 ! prostate gland
creation_date: 2010-09-20T03:21:06Z
[Term]
id: CL:0002341
name: basal cell of prostate epithelium
def: "An undifferentiated cell of the prostate epithelium that lacks secretory activity." [GOC:tfm, PMCID:PMC2673349]
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:0002231 ! epithelial cell of prostate
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002341" xsd:string {name="basal cell of prostate epithelium on CELLxGENE CellGuide"}
creation_date: 2010-09-20T03:34:10Z
[Term]
id: CL:0002344
name: CD56-negative, CD161-positive immature natural killer cell, human
def: "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-negative, CD117-positive, CD122-positive,and CD161-positive." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12457618]
comment: Human markers; killer cell immunoglobulin-like receptor 2DL1 is used as a representative example (PRO at this time lacks a KIR superfamily).
synonym: "p-NK" RELATED [PMID:12457618]
is_a: CL:0000823 ! immature natural killer cell
intersection_of: CL:0000823 ! immature natural killer cell
intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: RO:0002104 PR:000001381 ! has plasma membrane part interleukin-2 receptor subunit beta
intersection_of: RO:0002104 PR:000001874 ! has plasma membrane part KLRB1-like protein
intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor
relationship: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 PR:000001381 ! has plasma membrane part interleukin-2 receptor subunit beta
relationship: RO:0002104 PR:000001874 ! has plasma membrane part KLRB1-like protein
relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor
creation_date: 2010-09-20T04:33:11Z
[Term]
id: CL:0002350
name: endocardial cell
def: "An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin." [GOC:tfm, ISSN:0452-3458]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "endocardial endothelial cell" EXACT []
synonym: "endothelial cell of endocardium" EXACT [FMA:75621]
xref: FMA:75621
is_a: CL:0010008 ! cardiac endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0002165 ! endocardium
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002165 ! endocardium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002350" xsd:string {name="endocardial cell on CELLxGENE CellGuide"}
creation_date: 2010-09-21T04:33:05Z
[Term]
id: CL:0002351
name: progenitor cell of endocrine pancreas
def: "A progenitor cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1." [GOC:tfm, PMID:20025937, PMID:20217494, PMID:22728667]
subset: cellxgene_subset
synonym: "pancreatic endocrine progenitor" EXACT []
synonym: "pancreatic islet progenitor cell" EXACT []
is_a: CL:0011026 ! progenitor cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-21T04:41:06Z
[Term]
id: CL:0002352
name: gestational hematopoietic stem cell
def: "A hematopoietic stem cell that exists during embryogenesis." [GOC:tfm, ISBN:978-60327-246-6]
is_a: CL:0000037 ! hematopoietic stem cell
intersection_of: CL:0000037 ! hematopoietic stem cell
intersection_of: part_of UBERON:0000922 ! embryo
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0000922 ! embryo
creation_date: 2010-09-22T09:05:13Z
[Term]
id: CL:0002353
name: fetal liver hematopoietic progenitor cell
def: "A hematopoietic stem cell that resides in the fetal liver. In mice, this cell type is first observed at E10.5. This cell type is MHC-positive, HSA-positive, AA4.1-positive, CD45-positive, Sca-1 positive, CD150-positive, CD48-negative and CD244-negative." [GOC:tfm, ISBN:978-1-60327-346-6, PMID:16569764]
is_a: CL:0002352 {is_inferred="true"} ! gestational hematopoietic stem cell
intersection_of: CL:0002352 ! gestational hematopoietic stem cell
intersection_of: CL:4030046 PR:000001308 ! lacks_plasma_membrane_part CD48 molecule
intersection_of: CL:4030046 PR:000001896 ! lacks_plasma_membrane_part natural killer cell receptor 2B4
intersection_of: RO:0002104 GO:0042611 ! has plasma membrane part MHC protein complex
intersection_of: RO:0002104 PR:000001006 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C
intersection_of: RO:0002104 PR:000001833 ! has plasma membrane part SLAM family member 1
intersection_of: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24
intersection_of: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor
intersection_of: RO:0002104 PR:000002979 ! has plasma membrane part lymphocyte antigen 6A-2/6E-1
relationship: CL:4030046 PR:000001308 ! lacks_plasma_membrane_part CD48 molecule
relationship: CL:4030046 PR:000001896 ! lacks_plasma_membrane_part natural killer cell receptor 2B4
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002107 ! liver
relationship: RO:0002104 GO:0042611 ! has plasma membrane part MHC protein complex
relationship: RO:0002104 PR:000001006 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C
relationship: RO:0002104 PR:000001833 ! has plasma membrane part SLAM family member 1
relationship: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24
relationship: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor
relationship: RO:0002104 PR:000002979 ! has plasma membrane part lymphocyte antigen 6A-2/6E-1
creation_date: 2010-09-22T09:08:32Z
[Term]
id: CL:0002354
name: yolk sac hematopoietic stem cell
def: "A hematopoietic stem found in the yolk sac. In mice, this cell type is Sca-1-negative, CD45-negative, MHC-negative, HSA-positive, AA4.1-positive, CD44-positive." [doi:10.1097/MOH.0b013e3282f97ae1, GOC:tfm]
synonym: "hemangioblast precursor" EXACT []
is_a: CL:0002352 {is_inferred="true"} ! gestational hematopoietic stem cell
intersection_of: CL:0002352 ! gestational hematopoietic stem cell
intersection_of: CL:4030046 GO:0042611 ! lacks_plasma_membrane_part MHC protein complex
intersection_of: CL:4030046 PR:000001006 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C
intersection_of: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1
intersection_of: RO:0002104 PR:000001307 ! has plasma membrane part CD44 molecule
intersection_of: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24
intersection_of: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor
relationship: CL:4030046 GO:0042611 ! lacks_plasma_membrane_part MHC protein complex
relationship: CL:4030046 PR:000001006 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C
relationship: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001040 ! yolk sac
relationship: RO:0002104 PR:000001307 ! has plasma membrane part CD44 molecule
relationship: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24
relationship: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor
creation_date: 2010-09-22T09:08:34Z
[Term]
id: CL:0002359
name: placental hematopoietic stem cell
def: "A hematopoietic stem cell of the placenta. This cell type is first observed E10.5 This cell type may give rise to fetal liver hematopoietic stem cells." [GOC:tfm, ISBN:978-1-60327-346-6]
is_a: CL:0002352 ! gestational hematopoietic stem cell
intersection_of: CL:0000037 ! hematopoietic stem cell
intersection_of: part_of UBERON:0001987 ! placenta
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001987 ! placenta
creation_date: 2010-09-22T10:30:02Z
[Term]
id: CL:0002362
name: cerebellar granule cell precursor
def: "A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and HNK1-positive." [GOC:tfm, PMID:14745007]
subset: cellxgene_subset
synonym: "GCP" RELATED OMO:0003000 [doi:10.3389/fncir.2020.611841]
synonym: "granule cell precursor" BROAD [doi:10.3389/fncir.2020.611841]
synonym: "granule cell progenitor" BROAD [doi:10.3389/fncir.2020.611841]
is_a: CL:0000031 ! neuroblast (sensu Vertebrata)
is_a: CL:0002319 ! neural cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0009841 ! upper rhombic lip
creation_date: 2010-09-22T01:40:44Z
[Term]
id: CL:0002363
name: keratocyte
def: "A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic morphology; located between the lamellae with a large flattened nucleus, and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratan sulfate." [GOC:tfm, ISBN:9780702029585]
subset: cellxgene_subset
subset: eye_upper_slim
subset: human_reference_atlas
synonym: "corneal fibroblast" EXACT []
synonym: "corneal keratocyte" EXACT []
is_a: CL:0000005 ! neural crest derived fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001777 ! substantia propria of cornea
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001777 ! substantia propria of cornea
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002363" xsd:string {name="keratocyte on CELLxGENE CellGuide"}
creation_date: 2010-09-22T01:57:40Z
[Term]
id: CL:0002364
name: cortical thymic epithelial cell
def: "An epithelial cell of the cortical portion of the thymus. Epithelial cells in this region are required for positive selection of CD8-positive T cells." [GOC:tfm, PMID:18403190]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "cTEC" EXACT []
xref: BTO:0004562
is_a: CL:0002293 ! epithelial cell of thymus
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0002123 ! cortex of thymus
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002123 ! cortex of thymus
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002364" xsd:string {name="cortical thymic epithelial cell on CELLxGENE CellGuide"}
creation_date: 2010-09-23T03:17:12Z
[Term]
id: CL:0002365
name: medullary thymic epithelial cell
def: "An epithelial cell of the medullary thymus. This cell type expresses a diverse range of tissue-specific antigens. This promiscuous gene expression is a cell-autonomous property of medullary epithelial cells and is maintained during the entire period of thymic T cell output." [GOC:tfm, PMID:18180458]
subset: cellxgene_subset
synonym: "mTEC" EXACT []
xref: BTO:0004563
is_a: CL:0002293 ! epithelial cell of thymus
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0002124 ! medulla of thymus
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002124 ! medulla of thymus
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002365" xsd:string {name="medullary thymic epithelial cell on CELLxGENE CellGuide"}
creation_date: 2010-09-23T03:17:14Z
[Term]
id: CL:0002366
name: myometrial cell
def: "A smooth muscle cell of the myometrium that enlarges and stretches during pregnancy, and contracts in response to oxytocin." [GOC:tfm, PMID:11429640]
subset: cellxgene_subset
synonym: "myometrium smooth muscle cell" EXACT []
xref: BTO:0004519
is_a: CL:0002601 ! uterine smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0001296 ! myometrium
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001296 ! myometrium
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002366" xsd:string {name="myometrial cell on CELLxGENE CellGuide"}
creation_date: 2010-09-23T03:46:34Z
[Term]
id: CL:0002367
name: trabecular meshwork cell
def: "An ocular connective tissue cell that is part of the eye's trabecular meshwork and is directly responsible for regulating the outflow of aqueous humor from the anterior chamber of the eye, thereby maintaining proper intraocular pressure." [GOC:tfm, PMID:14500801, PMID:40136401]
subset: cellxgene_subset
synonym: "trabeculocyte" EXACT []
is_a: CL:0002320 {is_inferred="true"} ! connective tissue cell
intersection_of: CL:0002320 ! connective tissue cell
intersection_of: part_of UBERON:0005969 ! eye trabecular meshwork
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0005969 ! eye trabecular meshwork
creation_date: 2010-09-23T04:18:50Z
[Term]
id: CL:0002368
name: respiratory tract epithelial cell
def: "An epithelial cell of the respiratory tract epithelium. These cells have an endodermal origin." [GOC:tfm]
subset: cellxgene_subset
synonym: "airway epithelial cell" EXACT []
synonym: "respiratory epithelial cell" EXACT []
xref: BTO:0004533
is_a: CL:0002076 ! endo-epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0004802 ! respiratory tract epithelium
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0004802 ! respiratory tract epithelium
creation_date: 2010-09-23T04:38:49Z
[Term]
id: CL:0002370
name: respiratory tract goblet cell
def: "A simple columnar epithelial cell that secretes mucin. Rough endoplasmic reticulum, mitochondria, the nucleus, and other organelles are concentrated in the basal portion. The apical plasma membrane projects microvilli to increase surface area for secretion." [GOC:tfm, ISBN:0721662544]
subset: cellxgene_subset
synonym: "respiratory goblet cell" EXACT []
synonym: "respiratory mucosa goblet cells" EXACT [MP:0010863]
is_a: CL:0000160 ! goblet cell
is_a: CL:0008055 ! respiratory tract secretory epithelial cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0004802 ! respiratory tract epithelium
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0004802 ! respiratory tract epithelium
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002370" xsd:string {name="respiratory tract goblet cell on CELLxGENE CellGuide"}
creation_date: 2010-09-23T04:42:27Z
[Term]
id: CL:0002372
name: myotube
def: "A transversely striated, multinucleated syncytial muscle cell, formed by the fusion of myoblasts during muscle development." [GOC:dos, GOC:tfm, ISBN:0323052908, PMID:22274696]
subset: cellxgene_subset
synonym: "myofiber" EXACT [FBbt:00005812]
synonym: "myofibril" EXACT [FBbt:00005812]
xref: FBbt:00005812 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
is_a: CL:0000737 ! striated muscle cell
is_a: CL:4052002 ! syncytial cell
intersection_of: CL:0000187 ! muscle cell
intersection_of: has_part GO:0030017 ! sarcomere
intersection_of: RO:0000053 PATO:0001908 ! has characteristic multinucleate
intersection_of: RO:0000053 PATO:0002478 ! has characteristic transversely striated
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: has_part GO:0030017 ! sarcomere
relationship: RO:0000053 PATO:0001908 ! has characteristic multinucleate
relationship: RO:0000053 PATO:0002478 ! has characteristic transversely striated
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002372" xsd:string {name="myotube on CELLxGENE CellGuide"}
creation_date: 2010-09-24T01:13:01Z
[Term]
id: CL:0002374
name: ear hair cell
def: "A hair cell of the ear that contains the organs of balance and hearing." [GOC:dph, GOC:tfm, ISBN:0192801023]
synonym: "ear receptor cell" EXACT []
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000855 ! sensory hair cell
intersection_of: CL:0000855 ! sensory hair cell
intersection_of: part_of UBERON:0001690 ! ear
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001690 ! ear
creation_date: 2010-09-24T01:49:31Z
[Term]
id: CL:0002375
name: Schwann cell precursor
def: "A multipotent progenitor cell that develops from a migratory neural crest cell. The schwann cell precursor is embedded among axons, with minimal extracellular space separating them from nerve cell membranes. This cell lacks a basal lamina, which distinguishes it from more mature Schwann cells. In rodents, cadherin-19 (Cdh19) serves as a specific marker for this developmental stage." [GOC:tfm, PMID:15580626, PMID:30971890, PMID:35815410]
comment: Schwann cell precursor are capable of differentiating into Schwann cells and other cell types such as melanocytes, neurons, and mesenchymal cells. {xref="PMID:35815410"}
subset: cellxgene_subset
synonym: "Schwann cell precursor cell" EXACT []
synonym: "SCP" RELATED OMO:0003000 [PMID:35815410]
is_a: CL:0011026 ! progenitor cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0000333 ! migratory neural crest cell
relationship: has_potential_to_develop_into CL:0002573 ! Schwann cell
relationship: RO:0000053 PATO:0001402 ! has characteristic multipotent
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002375" xsd:string {name="Schwann cell precursor on CELLxGENE CellGuide"}
creation_date: 2010-09-24T02:06:10Z
[Term]
id: CL:0002377
name: immature Schwann cell
def: "A glial cell that develops from a Schwann cell precursor. The immature Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. Immature Schwann cell can be found communally ensheathing large groups of axons." [GOC:cvs, GOC:tfm, ISBN:0721662544]
subset: cellxgene_subset
synonym: "Schwann cell" BROAD []
xref: ZFA:0001725 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0002573 ! Schwann cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002375 ! Schwann cell precursor
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002377" xsd:string {name="immature Schwann cell on CELLxGENE CellGuide"}
creation_date: 2010-09-24T02:10:31Z
[Term]
id: CL:0002393
name: intermediate monocyte
def: "A monocyte that has characteristics of both patrolling and inflammatory monocytes." [GOC:tfm, PMID:20628149, PMID:20870168]
subset: cellxgene_subset
is_a: CL:0000576 ! monocyte
intersection_of: CL:0000576 ! monocyte
intersection_of: CL:4030044 GO:0030224 ! has_not_completed monocyte differentiation
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001199 ! lacks_plasma_membrane_part C-C chemokine receptor type 2
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030044 GO:0030224 ! has_not_completed monocyte differentiation
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001199 ! lacks_plasma_membrane_part C-C chemokine receptor type 2
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0000860 ! classical monocyte
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002393" xsd:string {name="intermediate monocyte on CELLxGENE CellGuide"}
creation_date: 2010-10-04T10:52:03Z
[Term]
id: CL:0002395
name: Gr1-high classical monocyte
def: "A resident monocyte that is Gr-1 high, CD43-negative, CX3CR1-negative, CD115-positive, and B220-negative." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:20628149, PMID:27098205, PMID:8890901]
comment: Markers are associated with mice. The Gr epitope is used to describe this cell type is found on both Ly6c and Ly6g. However, its the Ly6c that is considered the specific marker, and thus used in the cross-product.
is_a: CL:0000860 {is_inferred="true"} ! classical monocyte
is_a: CL:0001022 ! CD115-positive monocyte
intersection_of: CL:0000860 ! classical monocyte
intersection_of: CL:4030046 PR:000001014 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
intersection_of: CL:4030046 PR:000001206 ! lacks_plasma_membrane_part CX3C chemokine receptor 1
intersection_of: CL:4030046 PR:000001879 ! lacks_plasma_membrane_part leukosialin
intersection_of: in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
intersection_of: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor
intersection_of: RO:0015015 PR:000002980 ! has high plasma membrane amount lymphocyte antigen 6C2
relationship: CL:4030046 PR:000001014 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
relationship: CL:4030046 PR:000001206 ! lacks_plasma_membrane_part CX3C chemokine receptor 1
relationship: CL:4030046 PR:000001879 ! lacks_plasma_membrane_part leukosialin
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: in_taxon NCBITaxon:10090 ! Mus musculus
relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
relationship: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor
relationship: RO:0015015 PR:000002980 ! has high plasma membrane amount lymphocyte antigen 6C2
creation_date: 2010-10-04T11:26:18Z
[Term]
id: CL:0002397
name: CD14-positive, CD16-positive monocyte
def: "A CD14-positive monocyte that is also CD16-positive and CCR2-negative." [GOC:tfm, PMID:20628149, PMID:21937707, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16+ monocyte'. Markers are associated with human cells. Note that this cell type encompasses both human intermediate monocytes (CD14+, CD16-low), and human non-classical monocytes (CD14-low, CD16+).
subset: cellxgene_subset
synonym: "CD16+ monocyte" EXACT [PMID:22343568]
is_a: CL:0001054 ! CD14-positive monocyte
intersection_of: CL:0001054 ! CD14-positive monocyte
intersection_of: CL:4030046 PR:000001199 ! lacks_plasma_membrane_part C-C chemokine receptor type 2
intersection_of: RO:0002104 PR:000001483 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor III
relationship: CL:4030046 PR:000001199 ! lacks_plasma_membrane_part C-C chemokine receptor type 2
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: RO:0002104 PR:000001483 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor III
creation_date: 2010-10-04T12:49:47Z
[Term]
id: CL:0002398
name: Gr1-positive, CD43-positive monocyte
def: "An intermediate monocyte that is Gr1-positive, CD43-positive." [GOC:tfm, PMID:20628149, PMID:27098205]
is_a: CL:0001022 ! CD115-positive monocyte
is_a: CL:0002393 ! intermediate monocyte
intersection_of: CL:0000576 ! monocyte
intersection_of: in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
intersection_of: RO:0002104 PR:000001879 ! has plasma membrane part leukosialin
intersection_of: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor
intersection_of: RO:0002104 PR:000002980 ! has plasma membrane part lymphocyte antigen 6C2
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002395 ! Gr1-high classical monocyte
relationship: in_taxon NCBITaxon:10090 ! Mus musculus
relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
relationship: RO:0002104 PR:000001879 ! has plasma membrane part leukosialin
relationship: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor
relationship: RO:0002104 PR:000002980 ! has plasma membrane part lymphocyte antigen 6C2
creation_date: 2010-10-04T12:49:49Z
[Term]
id: CL:0002400
name: fraction B/C precursor B cell
def: "A precursor B cell that is AA4-positive, IgM-negative, CD19-positive, CD43-positive and HSA-positive." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:37442242]
is_a: CL:0000817 {is_inferred="true"} ! precursor B cell
intersection_of: CL:0000817 ! precursor B cell
intersection_of: CL:4030046 GO:0071753 ! lacks_plasma_membrane_part IgM immunoglobulin complex
intersection_of: in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: RO:0002104 PR:000001002 ! has plasma membrane part CD19 molecule
intersection_of: RO:0002104 PR:000001879 ! has plasma membrane part leukosialin
intersection_of: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24
intersection_of: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor
relationship: CL:4030046 GO:0071753 ! lacks_plasma_membrane_part IgM immunoglobulin complex
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: in_taxon NCBITaxon:10090 ! Mus musculus
relationship: RO:0002104 PR:000001002 ! has plasma membrane part CD19 molecule
relationship: RO:0002104 PR:000001879 ! has plasma membrane part leukosialin
relationship: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24
relationship: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor
creation_date: 2010-10-05T10:11:38Z
[Term]
id: CL:0002402
name: Peyer's patch B cell
def: "A resting mature B cell within the Peyer's patch that is CD19-positive, B220-positive, IgM-positive, AA4-negative, CD23-positive, CD43-negative, and CD5-negative." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "Peyers patch B cell" EXACT []
is_a: CL:0000822 ! B-2 B cell
is_a: CL:0009014 ! Peyer's patch lymphocyte
intersection_of: CL:0000785 ! mature B cell
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
intersection_of: CL:4030046 PR:000001879 ! lacks_plasma_membrane_part leukosialin
intersection_of: CL:4030046 PR:000002037 ! lacks_plasma_membrane_part complement component C1q receptor
intersection_of: part_of UBERON:0001211 ! Peyer's patch
intersection_of: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex
intersection_of: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
intersection_of: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1
intersection_of: RO:0002104 PR:000001338 ! has plasma membrane part complement receptor type 2
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001879 ! lacks_plasma_membrane_part leukosialin
relationship: CL:4030046 PR:000002037 ! lacks_plasma_membrane_part complement component C1q receptor
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001211 ! Peyer's patch
relationship: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex
relationship: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
relationship: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1
relationship: RO:0002104 PR:000001338 ! has plasma membrane part complement receptor type 2
creation_date: 2010-10-05T11:18:03Z
[Term]
id: CL:0002420
name: immature T cell
def: "A T cell that has not completed T cell selection." [GOC:tfm]
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
synonym: "immature T-cell" EXACT []
xref: BTO:0001372
xref: CALOHA:TS-1042
is_a: CL:0000084 {is_inferred="true"} ! T cell
intersection_of: CL:0000084 ! T cell
intersection_of: CL:4030044 GO:0045058 ! has_not_completed T cell selection
relationship: CL:4030044 GO:0045058 ! has_not_completed T cell selection
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: RO:0000053 PATO:0001501 ! has characteristic immature
creation_date: 2010-10-12T01:56:17Z
[Term]
id: CL:0002421
name: nucleated reticulocyte
def: "A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles." [GOC:tfm, PMID:18182572, PMID:9011180, PMID:9046052]
is_a: CL:0000558 {is_inferred="true"} ! reticulocyte
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000558 ! reticulocyte
intersection_of: RO:0000053 PATO:0002505 ! has characteristic nucleated
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: RO:0000053 PATO:0002505 ! has characteristic nucleated
creation_date: 2010-10-15T09:24:05Z
[Term]
id: CL:0002422
name: enucleated reticulocyte
def: "A reticulocyte lacking a nucleus and showing a basophilic reticulum under vital staining due to the presence of ribosomes." [GOC:tfm, ISBN:0-12203-052-4, ISBN:0721601464]
subset: cellxgene_subset
xref: CALOHA:TS-0864
xref: FMA:66785
is_a: CL:0000225 ! anucleate cell
is_a: CL:0000558 {is_inferred="true"} ! reticulocyte
intersection_of: CL:0000558 ! reticulocyte
intersection_of: has_part GO:0005840 ! ribosome
intersection_of: RO:0000053 PATO:0001405 ! has characteristic anucleate
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: has_part GO:0005840 ! ribosome
relationship: RO:0000053 PATO:0001405 ! has characteristic anucleate
creation_date: 2010-10-15T09:24:08Z
[Term]
id: CL:0002425
name: early T lineage precursor
def: "A pro-T cell that is lin-negative, CD25-negative, CD127-negative, CD44-positive and kit-positive." [GOC:dsd, GOC:tfm, http://www.immgen.org/index_content.html, PMID:16551251]
comment: ETPs are reportedly CD1a-negative, CD4-negative, CD7-positive, CD8a-negative, CD8b-negative, CD33-low, CD34-high, CD38-low, CD45RA-positive, and CD45RO-negative.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "ETP" EXACT []
synonym: "preT.ETP.Th" EXACT []
is_a: CL:0000827 {is_inferred="true"} ! pro-T cell
intersection_of: CL:0000827 ! pro-T cell
intersection_of: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha
intersection_of: RO:0002104 PR:000001307 ! has plasma membrane part CD44 molecule
intersection_of: RO:0002104 PR:000001869 ! has plasma membrane part interleukin-7 receptor subunit alpha
intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor
relationship: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 PR:000001307 ! has plasma membrane part CD44 molecule
relationship: RO:0002104 PR:000001869 ! has plasma membrane part interleukin-7 receptor subunit alpha
relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor
creation_date: 2010-10-21T01:16:24Z
[Term]
id: CL:0002453
name: oligodendrocyte precursor cell
def: "A proliferative and migratory glial progenitor cell that derives from a neural stem cell and resides within the central nervous system. It possesses the capacity to differentiate into a committed oligodendrocyte progenitor (COP) through a well-defined series of maturation steps, ultimately giving rise to a myelinating oligodendrocyte (MOL). In mice and humans, it is characterized by the expression of specific molecular markers, including Pdgfra, Cspg4 (also known as NG2) and Olig2." [GOC:tfm, PMID:16367798, PMID:20142420, PMID:31583586, PMID:31726662, PMID:37653126]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "NG2 cell" RELATED [PMID:14501223]
synonym: "O2-A" RELATED OMO:0003000 [PMID:2182078]
synonym: "OPC" RELATED OMO:0003000 [PMID:14501223]
synonym: "Polydendrocyte" RELATED [PMID:23516142]
xref: MESH:D000073637
is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata)
is_a: CL:0011026 ! progenitor cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0000047 ! neural stem cell
relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata)
relationship: develops_into CL:4023059 ! committed oligodendrocyte precursor
relationship: part_of CL:0000125 ! glial cell
relationship: part_of UBERON:0001017 ! central nervous system
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002453" xsd:string {name="oligodendrocyte precursor cell on CELLxGENE CellGuide"}
creation_date: 2010-11-10T02:51:34Z
[Term]
id: CL:0002454
name: CD4-negative, CD8-alpha-negative, CD11b-positive dendritic cell
def: "CD4-negative, CD8-alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8-alpha-negative and is CD205-positive." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "DC.8-4-11b+" EXACT []
synonym: "spleen double-negative dendritic cell" EXACT []
is_a: CL:0002465 {is_inferred="true"} ! CD11b-positive dendritic cell
intersection_of: CL:0002465 ! CD11b-positive dendritic cell
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-11-22T01:10:28Z
[Term]
id: CL:0002457
name: epidermal Langerhans cell
def: "A Langerhans cell that is in the epidermis and is CD45-positive, MHCII-positive, and CD11b-positive." [GOC:tfm, http://www.immgen.org/index_content.html]
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:0000453 {is_inferred="true"} ! Langerhans cell
is_a: CL:0002465 ! CD11b-positive dendritic cell
intersection_of: CL:0000453 ! Langerhans cell
intersection_of: located_in UBERON:0001003 ! skin epidermis
intersection_of: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex
intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
intersection_of: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: located_in UBERON:0001003 ! skin epidermis
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex
relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
relationship: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
creation_date: 2010-11-22T03:57:57Z
[Term]
id: CL:0002460
name: CD8-alpha-negative thymic conventional dendritic cell
def: "A conventional thymic dendritic cell that is CD8-alpha-negative." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:19273629]
subset: human_reference_atlas
synonym: "DC.8-.Th" EXACT []
is_a: CL:0000941 {is_inferred="true"} ! thymic conventional dendritic cell
intersection_of: CL:0000941 ! thymic conventional dendritic cell
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2010-11-23T10:58:53Z
[Term]
id: CL:0002465
name: CD11b-positive dendritic cell
def: "A conventional dendritic cell that expresses CD11b (ITGAM)." [GOC:tfm, http://www.immgen.org/index_content.html]
is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
creation_date: 2010-11-23T01:50:05Z
[Term]
id: CL:0002467
name: Gr1-high myeloid suppressor cell
def: "A myeloid suppressor cell that is Gr1-high and CD11c-negative." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "MDS.Gr1hi" EXACT []
is_a: CL:0000889 {is_inferred="true"} ! myeloid suppressor cell
intersection_of: CL:0000889 ! myeloid suppressor cell
intersection_of: CL:4030046 PR:000001013 ! lacks_plasma_membrane_part integrin alpha-X
intersection_of: RO:0015015 PR:000002980 ! has high plasma membrane amount lymphocyte antigen 6C2
relationship: CL:4030046 PR:000001013 ! lacks_plasma_membrane_part integrin alpha-X
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: RO:0015015 PR:000002980 ! has high plasma membrane amount lymphocyte antigen 6C2
creation_date: 2010-11-23T02:15:12Z
[Term]
id: CL:0002468
name: Gr1-low myeloid suppressor cell
def: "A myeloid suppressor cell that is Gr1-low and CD11c-positive." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "MDS.Gr1lo" EXACT []
is_a: CL:0000889 {is_inferred="true"} ! myeloid suppressor cell
intersection_of: CL:0000889 ! myeloid suppressor cell
intersection_of: RO:0002104 PR:000001013 ! has plasma membrane part integrin alpha-X
intersection_of: RO:0015016 PR:000002980 ! has low plasma membrane amount lymphocyte antigen 6C2
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: RO:0002104 PR:000001013 ! has plasma membrane part integrin alpha-X
relationship: RO:0015016 PR:000002980 ! has low plasma membrane amount lymphocyte antigen 6C2
creation_date: 2010-11-23T02:19:43Z
[Term]
id: CL:0002469
name: MHC-II-negative classical monocyte
def: "Gr1-high monocyte that lacks MHC-II receptor complex." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "Mo.6C+II-" EXACT []
is_a: CL:0002395 {is_inferred="true"} ! Gr1-high classical monocyte
intersection_of: CL:0002395 ! Gr1-high classical monocyte
intersection_of: CL:4030046 GO:0042613 ! lacks_plasma_membrane_part MHC class II protein complex
relationship: CL:4030046 GO:0042613 ! lacks_plasma_membrane_part MHC class II protein complex
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-11-23T03:27:12Z
[Term]
id: CL:0002470
name: MHC-II-positive classical monocyte
def: "Gr1-high monocyte that has a MHC-II receptor complex." [GOC:tfm, http://www.immgen.org/index_content.html]
subset: cellxgene_subset
synonym: "Mo.6c+II" EXACT []
is_a: CL:0002395 {is_inferred="true"} ! Gr1-high classical monocyte
intersection_of: CL:0002395 ! Gr1-high classical monocyte
intersection_of: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex
creation_date: 2010-11-23T03:30:21Z
[Term]
id: CL:0002480
name: nasal mucosa goblet cell
def: "A goblet cell located in the nasal epithelium." [GOC:cjm, GOC:tfm]
comment: The marker set LYPD2, MUC5AC can identify the Human cell type nasal mucosa goblet cell in the lung with a confidence of 0.81 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"}
subset: cellxgene_subset
xref: MP:0002262
is_a: CL:0002370 ! respiratory tract goblet cell
is_a: CL:0002631 ! epithelial cell of upper respiratory tract
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0001826 ! nasal cavity mucosa
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001826 ! nasal cavity mucosa
relationship: part_of UBERON:0005384 ! nasal cavity epithelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0015004 CLM:1000027 ! has characterizing marker set
creation_date: 2010-12-03T03:03:02Z
[Term]
id: CL:0002481
name: peritubular myoid cell
def: "The flattened smooth myoepithelial cells of mesodermal origin that lie just outside the basal lamina of the seminiferous tubule." [GOC:cjm, GOC:tfm, MP:0006420]
subset: cellxgene_subset
is_a: CL:0000185 {is_inferred="true"} ! myoepithelial cell
is_a: CL:0002625 ! seminiferous tubule epithelial cell
intersection_of: CL:0000185 ! myoepithelial cell
intersection_of: part_of UBERON:0001343 ! seminiferous tubule of testis
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001343 ! seminiferous tubule of testis
creation_date: 2010-12-03T03:11:48Z
[Term]
id: CL:0002482
name: dermal melanocyte
def: "A melanocyte that produces pigment in the dermis." [GOC:cjm, GOC:tfm, MP:0009386]
is_a: CL:1000458 ! melanocyte of skin
intersection_of: CL:0000148 ! melanocyte
intersection_of: part_of UBERON:0002067 ! dermis
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002067 ! dermis
creation_date: 2010-12-03T03:17:05Z
[Term]
id: CL:0002483
name: hair follicle melanocyte
def: "A melanocyte that produces pigment within the hair follicle." [GOC:tfm, MP:0004381]
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:0002559 ! hair follicle cell
is_a: CL:2000000 ! epidermal melanocyte
intersection_of: CL:0000148 ! melanocyte
intersection_of: part_of UBERON:0002073 ! hair follicle
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002073 ! hair follicle
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2010-12-03T03:17:09Z
[Term]
id: CL:0002484
name: epithelial melanocyte
def: "A melanocyte that produces pigment in the epithelium." [GOC:tfm, MP:0009388]
comment: The text defintion reference to the MP term appears to reference an epidermal melanocyte term. This term represents any melanocyte in any epithelium.
is_a: CL:0000148 {is_inferred="true"} ! melanocyte
intersection_of: CL:0000148 ! melanocyte
intersection_of: part_of UBERON:0000483 ! epithelium
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0000483 ! epithelium
creation_date: 2010-12-03T03:17:14Z
[Term]
id: CL:0002485
name: retinal melanocyte
def: "A melanocyte of the retina. This cell type is distinct from pigmented retinal epithelium." [GOC:tfm, MP:0010190]
subset: eye_upper_slim
is_a: CL:0000148 ! melanocyte
is_a: CL:0009004 ! retinal cell
intersection_of: CL:0000148 ! melanocyte
intersection_of: part_of UBERON:0000966 ! retina
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0000966 ! retina
creation_date: 2010-12-03T03:25:32Z
[Term]
id: CL:0002486
name: strial intermediate cell
def: "A melanocyte located between the epithelial marginal cell layer and the mesodermal basal cell layer within the intrastrial space; the predominant cellular component of the electrogenic machinery that generates an endocochlear potential (80-100 mV) ." [GOC:tfm, MP:0000048]
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:0002484 ! epithelial melanocyte
is_a: CL:0002491 ! auditory epithelial cell
intersection_of: CL:0000148 ! melanocyte
intersection_of: part_of UBERON:0002282 ! stria vascularis of cochlear duct
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002282 ! stria vascularis of cochlear duct
creation_date: 2010-12-03T03:29:15Z
[Term]
id: CL:0002490
name: organ of Corti supporting cell
def: "A supporting cell of the organ of Corti." [GOC:tfm, MP:0004300]
is_a: CL:0002315 ! supporting cell of cochlea
intersection_of: CL:0005014 ! auditory epithelial supporting cell
intersection_of: part_of UBERON:0002227 ! spiral organ of cochlea
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002227 ! spiral organ of cochlea
creation_date: 2010-12-06T03:09:01Z
[Term]
id: CL:0002491
name: auditory epithelial cell
def: "A specialized cell involved in auditory sensory perception." [GOC:tfm]
subset: cellxgene_subset
is_a: CL:0000098 ! sensory epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: capable_of GO:0050910 ! detection of mechanical stimulus involved in sensory perception of sound
relationship: capable_of GO:0050910 ! detection of mechanical stimulus involved in sensory perception of sound
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-12-06T03:18:43Z
[Term]
id: CL:0002494
name: cardiocyte
def: "A cell located in the heart, including both muscle and non muscle cells." [GOC:tfm]
comment: From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart.
synonym: "heart cell" EXACT []
xref: BTO:0001539
xref: CALOHA:TS-0115
xref: FMA:83808
xref: FMA:84791
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0007100 ! primary circulatory organ
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0007100 ! primary circulatory organ
creation_date: 2010-12-07T09:37:22Z
[Term]
id: CL:0002499
name: spongiotrophoblast cell
def: "A trophoblast cell that arises in the junctional zone (basal plate) of the placenta." [GOC:tfm, MP:0008959]
synonym: "spongiotrophoblast" EXACT []
is_a: CL:0000351 ! trophoblast cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0004021 ! spongiotrophoblast layer
creation_date: 2010-12-07T12:56:56Z
[Term]
id: CL:0002503
name: adventitial cell
def: "A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc" [GOC:tfm]
subset: cellxgene_subset
xref: BTO:0002441
xref: FMA:84639
is_a: CL:0000630 ! supporting cell
is_a: CL:0002320 ! connective tissue cell
intersection_of: CL:0002320 ! connective tissue cell
intersection_of: part_of UBERON:0005742 ! adventitia
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0005742 ! adventitia
creation_date: 2010-12-07T04:03:56Z
[Term]
id: CL:0002504
name: enteric smooth muscle cell
def: "A smooth muscle cell of the intestine." [GOC:tfm]
subset: cellxgene_subset
synonym: "intestinal smooth muscle cell" EXACT []
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0000160 ! intestine
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0000160 ! intestine
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002504" xsd:string {name="enteric smooth muscle cell on CELLxGENE CellGuide"}
creation_date: 2011-01-17T03:39:38Z
[Term]
id: CL:0002507
name: langerin-positive lymph node dendritic cell
def: "A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-positive, MHC-II-positive, and CD4-negative and CD8a-negative." [GOC:tfm, http://www.immgen.org/index_content.html]
is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex
intersection_of: RO:0002104 PR:000001293 ! has plasma membrane part C-type lectin domain family 4 member K
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex
relationship: RO:0002104 PR:000001293 ! has plasma membrane part C-type lectin domain family 4 member K
creation_date: 2011-01-21T01:57:00Z
[Term]
id: CL:0002518
name: kidney epithelial cell
def: "An epithelial cell of the kidney." [GOC:tfm, KUPO:SJ]
subset: cellxgene_subset
xref: KUPO:0001019
xref: ZFA:0009374 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000066 ! epithelial cell
is_a: CL:1000497 {is_inferred="true"} ! kidney cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0002113 ! kidney
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002113 ! kidney
creation_date: 2011-02-08T10:46:34Z
[Term]
id: CL:0002521
name: subcutaneous adipocyte
def: "An adipocyte that is part of subcutaneous adipose tissue." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "subcutaneous fat cell" EXACT []
is_a: CL:0000136 {is_inferred="true"} ! adipocyte
intersection_of: CL:0000136 ! adipocyte
intersection_of: part_of UBERON:0002190 ! subcutaneous adipose tissue
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002190 ! subcutaneous adipose tissue
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002521" xsd:string {name="subcutaneous adipocyte on CELLxGENE CellGuide"}
creation_date: 2011-02-21T02:51:22Z
[Term]
id: CL:0002522
name: renal filtration cell
def: "A renal filtration cell is a specialized cell of the renal system that filter fluids by charge, size or both." [GOC:tfm]
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000424 ! excretory cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001008 ! renal system
creation_date: 2011-02-08T01:37:59Z
[Term]
id: CL:0002523
name: mesonephric podocyte
def: "A specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the mesonephros." [GOC:tfm]
synonym: "mesonephric glomerular visceral epithelial cell" EXACT [ZFA:0001674]
is_a: CL:0000653 ! podocyte
intersection_of: CL:0000653 ! podocyte
intersection_of: part_of UBERON:0000080 ! mesonephros
relationship: dc-contributor https://orcid.org/0000-0002-2244-7917
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0000080 ! mesonephros
creation_date: 2011-02-08T01:58:30Z
[Term]
id: CL:0002525
name: metanephric podocyte
def: "A specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the metanephros." [GOC:tfm]
synonym: "metanephric glomerular visceral epithelial cell" EXACT [doi:10.1007/s004180050142]
is_a: CL:0000653 ! podocyte
intersection_of: CL:0000653 ! podocyte
intersection_of: part_of UBERON:0000081 ! metanephros
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0000081 ! metanephros
creation_date: 2011-02-08T02:02:13Z
[Term]
id: CL:0002535
name: epithelial cell of cervix
def: "An epithelial cell of the cervix." [GOC:tfm]
synonym: "cervical canal epithelial cell" EXACT [GOC:tfm]
synonym: "cervical canal of uterus epithelial cell" EXACT [GOC:tfm]
synonym: "cervix epithelial cell" EXACT [GOC:tfm]
synonym: "cervix of uterus epithelial cell" EXACT [GOC:tfm]
synonym: "epithelial cell of cervical canal" EXACT [GOC:tfm]
synonym: "epithelial cell of cervical canal of uterus" EXACT [GOC:tfm]
synonym: "epithelial cell of cervix of uterus" EXACT [GOC:tfm]
synonym: "epithelial cell of neck of uterus" EXACT [GOC:tfm]
synonym: "epithelial cell of uterine cervix" EXACT [GOC:tfm]
synonym: "neck of uterus epithelial cell" EXACT [GOC:tfm]
synonym: "uterine cervix epithelial cell" EXACT [GOC:tfm]
is_a: CL:0002149 ! epithelial cell of uterus
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0000002 ! uterine cervix
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0000002 ! uterine cervix
relationship: part_of UBERON:0004801 ! cervix epithelium
creation_date: 2011-02-24T08:20:08Z
[Term]
id: CL:0002536
name: epithelial cell of amnion
def: "An epithelial cell that is part of the amnion." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "amniotic epithelial cell" EXACT []
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0000305 ! amnion
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0000305 ! amnion
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2011-02-28T12:38:01Z
[Term]
id: CL:0002537
name: amnion mesenchymal stem cell
def: "A mesenchymal stem cell of the amnion membrane." [GOC:tfm, PMID:20446274, PMID:21339039]
synonym: "amniotic membrane stem cell" EXACT []
is_a: CL:0000134 ! mesenchymal stem cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: part_of UBERON:0000305 ! amnion
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0000305 ! amnion
creation_date: 2011-02-28T12:44:24Z
[Term]
id: CL:0002538
name: intrahepatic cholangiocyte
def: "An epithelial cell of the intrahepatic portion of the bile duct. These cells are flattened or cuboidal in shape, and have a small nuclear-to-cytoplasmic ratio relative to large/extrahepatic cholangiocytes." [GOC:tfm, PMID:23720296]
subset: cellxgene_subset
synonym: "small bile duct cholangiocyte" EXACT [PMID:23720296]
xref: ZFA:0009379 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:1000488 {is_inferred="true"} ! cholangiocyte
intersection_of: CL:1000488 ! cholangiocyte
intersection_of: part_of UBERON:0004823 ! intrahepatic bile duct epithelium
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0004823 ! intrahepatic bile duct epithelium
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002538" xsd:string {name="intrahepatic cholangiocyte on CELLxGENE CellGuide"}
creation_date: 2011-02-28T01:20:20Z
[Term]
id: CL:0002539
name: aortic smooth muscle cell
def: "A smooth muscle cell of the aorta." [GOC:tfm]
subset: cellxgene_subset
xref: BTO:0004577
is_a: CL:0019018 ! blood vessel smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: part_of UBERON:0004178 ! aorta smooth muscle tissue
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0004178 ! aorta smooth muscle tissue
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002539" xsd:string {name="aortic smooth muscle cell on CELLxGENE CellGuide"}
creation_date: 2011-02-28T01:42:12Z
[Term]
id: CL:0002540
name: mesenchymal stem cell of the bone marrow
def: "A mesenchymal stem cell that is part of the bone marrow." [GOC:tfm]
is_a: CL:0000134 ! mesenchymal stem cell
is_a: CL:0002092 ! bone marrow cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: part_of UBERON:0002371 ! bone marrow
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002371 ! bone marrow
creation_date: 2011-02-28T01:47:47Z
[Term]
id: CL:0002541
name: chorionic membrane mesenchymal stem cell
def: "A mesenchymal stem cell of the chorionic membrane." [GOC:tfm]
is_a: CL:0000134 ! mesenchymal stem cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: part_of UBERON:0003124 ! chorion membrane
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0003124 ! chorion membrane
creation_date: 2011-02-28T03:04:35Z
[Term]
id: CL:0002543
name: vein endothelial cell
def: "An endothelial cell that is part of the vein." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "endothelial cell of vein" EXACT []
synonym: "venous endothelial cell" EXACT []
xref: FMA:62104
xref: KUPO:0001099
is_a: CL:0000071 {is_inferred="true"} ! blood vessel endothelial cell
intersection_of: CL:0000071 ! blood vessel endothelial cell
intersection_of: part_of UBERON:0001638 ! vein
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001638 ! vein
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002543" xsd:string {name="vein endothelial cell on CELLxGENE CellGuide"}
creation_date: 2011-02-28T03:48:11Z
[Term]
id: CL:0002547
name: fibroblast of the aortic adventitia
def: "A fibroblast of the aortic adventitia." [GOC:tfm]
subset: cellxgene_subset
is_a: CL:1000306 {is_inferred="true"} ! fibroblast of tunica adventitia of artery
intersection_of: CL:1000306 ! fibroblast of tunica adventitia of artery
intersection_of: part_of UBERON:0004664 ! aorta tunica adventitia
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0004664 ! aorta tunica adventitia
creation_date: 2011-02-28T04:43:41Z
[Term]
id: CL:0002548
name: fibroblast of cardiac tissue
def: "A fibroblast that is part of the heart." [GOC:tfm]
subset: cellxgene_subset
synonym: "cardiac fibroblast" EXACT []
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
is_a: CL:0002494 {is_inferred="true"} ! cardiocyte
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0000948 ! heart
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0000948 ! heart
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002548" xsd:string {name="fibroblast of cardiac tissue on CELLxGENE CellGuide"}
creation_date: 2011-02-28T04:57:44Z
[Term]
id: CL:0002549
name: fibroblast of choroid plexus
def: "A fibroblast that is part of the choroid plexus." [GOC:tfm]
subset: cellxgene_subset
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001886 ! choroid plexus
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001886 ! choroid plexus
creation_date: 2011-02-28T05:01:39Z
[Term]
id: CL:0002550
name: fibroblast of the conjunctiva
def: "A fibroblast that is part of the conjuctiva of the eye." [GOC:tfm]
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001811 ! conjunctiva
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001811 ! conjunctiva
creation_date: 2011-02-28T05:03:44Z
[Term]
id: CL:0002551
name: fibroblast of dermis
def: "Any skin fibroblast that is part of some dermis." [FBC:Autogenerated]
subset: cellxgene_subset
is_a: CL:0002620 {is_inferred="true"} ! skin fibroblast
intersection_of: CL:0002620 ! skin fibroblast
intersection_of: part_of UBERON:0002067 ! dermis
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002067 ! dermis
creation_date: 2011-02-28T05:05:33Z
[Term]
id: CL:0002552
name: fibroblast of gingiva
def: "Any fibroblast that is part of some gingiva." [FBC:Autogenerated]
subset: cellxgene_subset
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001828 ! gingiva
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001828 ! gingiva
creation_date: 2011-02-28T05:09:12Z
[Term]
id: CL:0002553
name: fibroblast of lung
def: "A fibroblast that is part of lung." [GOC:tfm]
subset: cellxgene_subset
xref: BTO:0000764
xref: CALOHA:TS-0575
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0002048 ! lung
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002048 ! lung
creation_date: 2011-02-28T05:11:03Z
[Term]
id: CL:0002554
name: fibroblast of lymphatic vessel
def: "A fibroblast of the lymphatic system." [GOC:tfm]
subset: cellxgene_subset
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001473 ! lymphatic vessel
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001473 ! lymphatic vessel
creation_date: 2011-02-28T05:16:18Z
[Term]
id: CL:0002555
name: fibroblast of mammary gland
def: "A fibroblast that is part of the mammary gland." [GOC:tfm]
subset: cellxgene_subset
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001911 ! mammary gland
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001911 ! mammary gland
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002555" xsd:string {name="fibroblast of mammary gland on CELLxGENE CellGuide"}
creation_date: 2011-02-28T05:18:38Z
[Term]
id: CL:0002556
name: fibroblast of periodontium
def: "A fibroblast of the periodontium." [GOC:tfm]
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001758 ! periodontium
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001758 ! periodontium
creation_date: 2011-02-28T05:19:48Z
[Term]
id: CL:0002557
name: fibroblast of pulmonary artery
def: "A fibroblast of pulmonary artery." [GOC:tfm]
subset: human_reference_atlas
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0002012 ! pulmonary artery
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002012 ! pulmonary artery
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2011-02-28T05:22:27Z
[Term]
id: CL:0002559
name: hair follicle cell
def: "An animal cell that is part of a hair follicle." [GOC:tfm]
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0002073 ! hair follicle
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002073 ! hair follicle
creation_date: 2011-03-01T04:11:01Z
[Term]
id: CL:0002560
name: inner root sheath cell
def: "An epithelial cell that resides in the inner root sheath of the hair follicle." [GOC:tfm]
is_a: CL:0000362 ! epidermal cell
is_a: CL:0002559 {is_inferred="true"} ! hair follicle cell
intersection_of: CL:0002559 ! hair follicle cell
intersection_of: part_of UBERON:0005941 ! hair inner root sheath
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0005941 ! hair inner root sheath
creation_date: 2011-03-01T04:27:51Z
[Term]
id: CL:0002561
name: outer root sheath cell
def: "An epithelial cell that is part of the outer root sheath." [GOC:tfm]
is_a: CL:0000362 ! epidermal cell
is_a: CL:0002559 {is_inferred="true"} ! hair follicle cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0005942 ! hair outer root sheath
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0005942 ! hair outer root sheath
creation_date: 2011-03-01T04:29:47Z
[Term]
id: CL:0002562
name: hair germinal matrix cell
def: "An epidermal cell that is part of the germinal matrix." [GOC:tfm]
subset: human_reference_atlas
synonym: "trichocyte" EXACT []
is_a: CL:0000362 {is_inferred="true"} ! epidermal cell
is_a: CL:0002559 ! hair follicle cell
intersection_of: CL:0000362 ! epidermal cell
intersection_of: part_of UBERON:0006004 ! hair follicle matrix region
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0006004 ! hair follicle matrix region
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2011-03-01T04:31:06Z
[Term]
id: CL:0002563
name: intestinal epithelial cell
def: "An epithelial cell of the lining of the intestine." [GOC:tfm]
subset: cellxgene_subset
xref: ZFA:0009399 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0002251 ! epithelial cell of alimentary canal
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001277 ! intestinal epithelium
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001277 ! intestinal epithelium
creation_date: 2011-03-01T05:18:31Z
[Term]
id: CL:0002564
name: nucleus pulposus cell of intervertebral disc
def: "A connective tissue cell of the nucleus pulposus cell of intervertebral disc." [GOC:tfm]
is_a: CL:0002320 ! connective tissue cell
intersection_of: CL:0002320 ! connective tissue cell
intersection_of: part_of UBERON:0002242 ! nucleus pulposus
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002242 ! nucleus pulposus
creation_date: 2011-03-02T02:12:23Z
[Term]
id: CL:0002569
name: mesenchymal stem cell of umbilical cord
def: "A mesenchymal stem cell of the umbilical cord." [GOC:tfm]
is_a: CL:0000134 ! mesenchymal stem cell
is_a: CL:0000349 ! extraembryonic cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: part_of UBERON:0003422 ! mesenchyme of umbilical cord
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0003422 ! mesenchyme of umbilical cord
creation_date: 2011-03-01T09:55:12Z
[Term]
id: CL:0002570
name: mesenchymal stem cell of adipose tissue
def: "A mesenchymal stem cell of adipose tissue." [GOC:tfm]
subset: cellxgene_subset
synonym: "mesenchymal stem cell of adipose" EXACT []
is_a: CL:0000134 ! mesenchymal stem cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: part_of UBERON:0001013 ! adipose tissue
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001013 ! adipose tissue
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002570" xsd:string {name="mesenchymal stem cell of adipose tissue on CELLxGENE CellGuide"}
creation_date: 2011-03-01T09:57:17Z
[Term]
id: CL:0002571
name: hepatic mesenchymal stem cell
def: "A mesenchymal stem cell of liver." [GOC:tfm]
is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell
is_a: CL:0002195 ! hepatic stem cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: part_of UBERON:0002107 ! liver
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002107 ! liver
creation_date: 2011-03-01T09:58:51Z
[Term]
id: CL:0002572
name: vertebral mesenchymal stem cell
def: "A mesenchymal stem cell of the vertebrae." [GOC:tfm]
is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell
is_a: CL:0001035 ! bone cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: part_of UBERON:0002412 ! vertebra
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002412 ! vertebra
creation_date: 2011-03-01T10:40:27Z
[Term]
id: CL:0002573
name: Schwann cell
def: "A glial cell that myelinates or ensheathes axons in the peripheral nervous system." [GOC:tfm, PMID:16807057]
comment: A myelinating Schwann cell wraps around a single axon. Myelination occurs in larger diameter axons, while a process called ensheathment occurs on smaller diameter axons in which a single cell wraps around multiple small, unmyelinated axons separating them with a thin layer of cytoplasm. The structure formed is called a Remak bundle. {xref="PMID:16807057"}
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "neurolemmocyte" EXACT [PMID:32119275, PMID:38638689]
xref: BTO:0001220
xref: CALOHA:TS-0898
xref: MESH:D012583
is_a: CL:0000125 ! glial cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0000010 ! peripheral nervous system
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002573" xsd:string {name="Schwann cell on CELLxGENE CellGuide"}
creation_date: 2011-03-02T01:19:27Z
[Term]
id: CL:0002574
name: stromal cell of pancreas
def: "A stromal cell of the pancreas." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:0000499 {is_inferred="true"} ! stromal cell
intersection_of: CL:0000499 ! stromal cell
intersection_of: part_of UBERON:0001264 ! pancreas
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001264 ! pancreas
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2011-03-02T02:40:41Z
[Term]
id: CL:0002575
name: central nervous system pericyte
def: "A pericyte of the central nervous system." [GOC:tfm]
is_a: CL:0000669 {is_inferred="true"} ! pericyte
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000669 ! pericyte
intersection_of: part_of UBERON:0001017 ! central nervous system
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001017 ! central nervous system
creation_date: 2011-03-02T02:54:18Z
[Term]
id: CL:0002577
name: placental epithelial cell
def: "An epithelial cell of the placenta." [GOC:tfm]
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000349 {is_inferred="true"} ! extraembryonic cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001987 ! placenta
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001987 ! placenta
creation_date: 2011-03-02T03:21:30Z
[Term]
id: CL:0002578
name: mesenteric preadipocyte
def: "A preadipocyte found in mesenteric tissue." [GOC:tfm]
is_a: CL:0002334 {is_inferred="true"} ! preadipocyte
intersection_of: CL:0002334 ! preadipocyte
intersection_of: part_of UBERON:0002095 ! mesentery
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002095 ! mesentery
creation_date: 2011-03-03T04:19:40Z
[Term]
id: CL:0002579
name: omentum preadipocyte
def: "A preadipocyte that is part of an omentum." [PMID:21484051]
is_a: CL:0002334 {is_inferred="true"} ! preadipocyte
intersection_of: CL:0002334 ! preadipocyte
intersection_of: part_of UBERON:0003688 ! omentum
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0003688 ! omentum
creation_date: 2011-03-03T04:19:42Z
[Term]
id: CL:0002580
name: preadipocyte of the breast
def: "A preadipocyte that is part of the breast." [GOC:tfm]
is_a: CL:0002334 {is_inferred="true"} ! preadipocyte
is_a: CL:4006000 ! fibroblast of breast
intersection_of: CL:0002334 ! preadipocyte
intersection_of: part_of UBERON:0000310 ! breast
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0000310 ! breast
creation_date: 2011-03-03T04:19:46Z
[Term]
id: CL:0002581
name: perirenal preadipocyte
def: "A preadipocyte that is part of a perirenal fat tissue." [PMID:20106964, PMID:31079959]
is_a: CL:0002334 {is_inferred="true"} ! preadipocyte
intersection_of: CL:0002334 ! preadipocyte
intersection_of: part_of UBERON:0005406 ! perirenal fat
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0005406 ! perirenal fat
creation_date: 2011-03-03T04:20:04Z
[Term]
id: CL:0002583
name: subcutaneous preadipocyte
def: "A preadipocyte that is part of subcutaneous tissue." [GOC:tfm]
is_a: CL:0002334 {is_inferred="true"} ! preadipocyte
intersection_of: CL:0002334 ! preadipocyte
intersection_of: part_of UBERON:0002072 ! hypodermis
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002072 ! hypodermis
creation_date: 2011-03-03T04:33:01Z
[Term]
id: CL:0002584
name: renal cortical epithelial cell
def: "An epithelial cell of the kidney cortex." [GOC:tfm]
xref: KUPO:0001016
is_a: CL:0002518 {is_inferred="true"} ! kidney epithelial cell
is_a: CL:0002681 {is_inferred="true"} ! kidney cortical cell
intersection_of: CL:0002518 ! kidney epithelial cell
intersection_of: part_of UBERON:0001225 ! cortex of kidney
relationship: part_of UBERON:0001225 ! cortex of kidney
[Term]
id: CL:0002585
name: retinal blood vessel endothelial cell
def: "A blood vessel endothelial cell that is part of the retina." [GOC:tfm]
subset: cellxgene_subset
subset: eye_upper_slim
subset: human_reference_atlas
is_a: CL:0000071 {is_inferred="true"} ! blood vessel endothelial cell
is_a: CL:0009004 ! retinal cell
intersection_of: CL:0000071 ! blood vessel endothelial cell
intersection_of: part_of UBERON:0000966 ! retina
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0000966 ! retina
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002585" xsd:string {name="retinal blood vessel endothelial cell on CELLxGENE CellGuide"}
creation_date: 2011-03-06T03:28:27Z
[Term]
id: CL:0002586
name: retinal pigment epithelial cell
def: "An epithelial cell of the retinal pigmented epithelium." [GOC:tfm]
subset: cellxgene_subset
subset: eye_upper_slim
subset: human_reference_atlas
xref: BTO:0004910
xref: FMA:75802
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000149 ! visual pigment cell
is_a: CL:0009004 ! retinal cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001782 ! pigmented layer of retina
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: has_part GO:0042470 ! melanosome
relationship: part_of UBERON:0001782 ! pigmented layer of retina
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002586" xsd:string {name="retinal pigment epithelial cell on CELLxGENE CellGuide"}
creation_date: 2011-03-06T03:37:09Z
[Term]
id: CL:0002588
name: smooth muscle cell of the umbilical vein
def: "A smooth muscle cell of the umbilical vein." [GOC:tfm]
is_a: CL:0019018 ! blood vessel smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: part_of UBERON:0002066 ! umbilical vein
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002066 ! umbilical vein
creation_date: 2011-03-06T05:00:51Z
[Term]
id: CL:0002589
name: smooth muscle cell of the brachiocephalic vasculature
def: "A smooth muscle cell of the bachiocephalic vasculature." [GOC:tfm]
is_a: CL:0019018 ! blood vessel smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: part_of UBERON:0001529 ! brachiocephalic artery
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001529 ! brachiocephalic artery
creation_date: 2011-03-06T05:00:58Z
[Term]
id: CL:0002590
name: smooth muscle cell of the brain vasculature
def: "A vascular associated smooth muscle cell of the brain vasculature." [GOC:tfm]
subset: cellxgene_subset
is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: part_of UBERON:0000955 ! brain
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0000955 ! brain
creation_date: 2011-03-06T05:01:20Z
[Term]
id: CL:0002591
name: smooth muscle cell of the pulmonary artery
def: "A smooth muscle of the pulmonary artery." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
xref: BTO:0003336
is_a: CL:0019018 ! blood vessel smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: part_of UBERON:0002012 ! pulmonary artery
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002012 ! pulmonary artery
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002591" xsd:string {name="smooth muscle cell of the pulmonary artery on CELLxGENE CellGuide"}
creation_date: 2011-03-06T05:01:28Z
[Term]
id: CL:0002592
name: smooth muscle cell of the coronary artery
def: "A smooth muscle cell of the coronary artery." [GOC:tfm]
subset: human_reference_atlas
is_a: CL:0002494 ! cardiocyte
is_a: CL:0019018 ! blood vessel smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: part_of UBERON:0001621 ! coronary artery
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001621 ! coronary artery
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2011-03-06T05:01:34Z
[Term]
id: CL:0002593
name: smooth muscle cell of the internal thoracic artery
def: "A smooth muscle of the internal thoracic artery." [GOC:tfm]
is_a: CL:0002595 ! smooth muscle cell of the subclavian artery
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: part_of UBERON:0002456 ! internal thoracic artery
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002456 ! internal thoracic artery
creation_date: 2011-03-06T05:01:41Z
[Term]
id: CL:0002594
name: smooth muscle cell of the umbilical artery
def: "A smooth muscle cell of the umbilical artery." [GOC:tfm]
is_a: CL:0019018 ! blood vessel smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: part_of UBERON:0001310 ! umbilical artery
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001310 ! umbilical artery
creation_date: 2011-03-06T05:01:48Z
[Term]
id: CL:0002595
name: smooth muscle cell of the subclavian artery
def: "A smooth muscle cell of the subclavian artery." [GOC:tfm]
is_a: CL:0019018 ! blood vessel smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: part_of UBERON:0001533 ! subclavian artery
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001533 ! subclavian artery
creation_date: 2011-03-06T05:01:52Z
[Term]
id: CL:0002596
name: smooth muscle cell of the carotid artery
def: "Smooth muscle cell of the carotid artery." [GOC:tfm]
is_a: CL:0019018 ! blood vessel smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: part_of UBERON:0005396 ! carotid artery segment
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0005396 ! carotid artery segment
creation_date: 2011-03-06T05:01:56Z
[Term]
id: CL:0002597
name: smooth muscle cell of bladder
def: "A smooth muscle cell of the bladder." [GC:tfm]
subset: human_reference_atlas
xref: KUPO:0001122
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
is_a: CL:1001319 ! bladder cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0001255 ! urinary bladder
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001255 ! urinary bladder
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2011-03-06T05:43:24Z
[Term]
id: CL:0002598
name: bronchial smooth muscle cell
def: "Any smooth muscle cell that is part of some bronchus." [FBC:Autogenerated]
subset: cellxgene_subset
subset: human_reference_atlas
xref: BTO:0004402
is_a: CL:0019019 ! tracheobronchial smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0002185 ! bronchus
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002185 ! bronchus
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002598" xsd:string {name="bronchial smooth muscle cell on CELLxGENE CellGuide"}
creation_date: 2011-03-06T05:46:39Z
[Term]
id: CL:0002599
name: smooth muscle cell of the esophagus
def: "A smooth muscle cell of the esophagus." [GOC:tfm]
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0001043 ! esophagus
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001043 ! esophagus
creation_date: 2011-03-06T05:48:17Z
[Term]
id: CL:0002600
name: smooth muscle cell of trachea
def: "A smooth muscle cell of the trachea." [GOC:tfm]
subset: cellxgene_subset
is_a: CL:0019019 ! tracheobronchial smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0003126 ! trachea
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0003126 ! trachea
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002600" xsd:string {name="smooth muscle cell of trachea on CELLxGENE CellGuide"}
creation_date: 2011-03-06T05:50:28Z
[Term]
id: CL:0002601
name: uterine smooth muscle cell
def: "A smooth muscle cell of the uterus." [GOC:tfm]
subset: cellxgene_subset
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0000995 ! uterus
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0000995 ! uterus
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002601" xsd:string {name="uterine smooth muscle cell on CELLxGENE CellGuide"}
creation_date: 2011-03-06T05:53:28Z
[Term]
id: CL:0002602
name: annulus pulposus cell
def: "Any connective tissue cell that is part of some annulus fibrosus disci intervertebralis." [FBC:Autogenerated]
synonym: "anulus pulposus cell" EXACT []
is_a: CL:0002320 {is_inferred="true"} ! connective tissue cell
intersection_of: CL:0002320 ! connective tissue cell
intersection_of: part_of UBERON:0004715 ! annulus fibrosus disci intervertebralis
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0004715 ! annulus fibrosus disci intervertebralis
creation_date: 2011-03-06T06:50:53Z
[Term]
id: CL:0002603
name: astrocyte of the cerebellum
def: "An astrocyte of the cerebellum." [GOC:tfm]
subset: cellxgene_subset
is_a: CL:0000127 {is_inferred="true"} ! astrocyte
is_a: CL:2000005 ! brain macroglial cell
intersection_of: CL:0000127 ! astrocyte
intersection_of: part_of UBERON:0002037 ! cerebellum
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002037 ! cerebellum
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002603" xsd:string {name="astrocyte of the cerebellum on CELLxGENE CellGuide"}
creation_date: 2011-03-06T06:57:27Z
[Term]
id: CL:0002604
name: hippocampal astrocyte
def: "An astrocyte that is part of the hippocampus." [https://orcid.org/0000-0001-7258-9596]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "astrocyte of the hippocampal formation" EXACT []
synonym: "astrocyte of the hippocampus" EXACT []
is_a: CL:0002605 ! astrocyte of the cerebral cortex
is_a: CL:1001580 ! hippocampal glial cell
intersection_of: CL:0000127 ! astrocyte
intersection_of: part_of UBERON:0002421 ! hippocampal formation
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002421 ! hippocampal formation
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2011-03-06T06:57:33Z
[Term]
id: CL:0002605
name: astrocyte of the cerebral cortex
def: "A transcriptomically distinct astrocyte that is found in the cerebral cortex." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:0012000 ! astrocyte of the forebrain
is_a: CL:1001579 ! cerebral cortex glial cell
intersection_of: CL:0000127 ! astrocyte
intersection_of: part_of UBERON:0000956 ! cerebral cortex
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0000956 ! cerebral cortex
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2011-03-06T06:57:36Z
[Term]
id: CL:0002606
name: astrocyte of the spinal cord
def: "An astrocyte of the spinal cord." [GOC:tfm]
is_a: CL:0000127 {is_inferred="true"} ! astrocyte
intersection_of: CL:0000127 ! astrocyte
intersection_of: part_of UBERON:0002240 ! spinal cord
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002240 ! spinal cord
creation_date: 2011-03-06T07:11:26Z
[Term]
id: CL:0002607
name: migratory enteric neural crest cell
def: "A neural crest cell that gives rise to cells of the enteric nervous system." [GOC:tfm]
subset: cellxgene_subset
is_a: CL:0000333 ! migratory neural crest cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-03-06T07:24:35Z
[Term]
id: CL:0002608
name: hippocampal neuron
def: "A neuron with a soma found in the hippocampus." [GOC:tfm]
subset: cellxgene_subset
is_a: CL:0010012 ! cerebral cortex neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0002421 ! has soma location hippocampal formation
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: RO:0002100 UBERON:0002421 ! has soma location hippocampal formation
creation_date: 2011-03-06T07:31:49Z
[Term]
id: CL:0002610
name: raphe nuclei neuron
def: "A neuron of the raphe nuclei." [GOC:tfm]
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0004684 ! has soma location raphe nuclei
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: RO:0002100 UBERON:0004684 ! has soma location raphe nuclei
creation_date: 2011-03-06T07:42:06Z
[Term]
id: CL:0002611
name: neuron of the dorsal spinal cord
def: "A CNS neuron of the dorsal spinal cord." [GOC:tfm]
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0002256 ! has soma location dorsal horn of spinal cord
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: RO:0002100 UBERON:0002256 ! has soma location dorsal horn of spinal cord
creation_date: 2011-03-06T07:43:34Z
[Term]
id: CL:0002612
name: neuron of the ventral spinal cord
def: "A neuron of the ventral spinal cord." [GOC:tfm]
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0002257 ! has soma location ventral horn of spinal cord
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: RO:0002100 UBERON:0002257 ! has soma location ventral horn of spinal cord
creation_date: 2011-03-06T07:46:03Z
[Term]
id: CL:0002613
name: striatum neuron
def: "A neuron of the striatum." [GOC:tfm]
is_a: CL:0012001 ! neuron of the forebrain
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0002435 ! has soma location striatum
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: RO:0002100 UBERON:0002435 ! has soma location striatum
creation_date: 2011-03-06T07:47:12Z
[Term]
id: CL:0002614
name: neuron of the substantia nigra
def: "A neuron of the substantia nigra." [GOC:tfm]
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0002038 ! has soma location substantia nigra
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: RO:0002100 UBERON:0002038 ! has soma location substantia nigra
creation_date: 2011-03-06T07:48:42Z
[Term]
id: CL:0002615
name: adipocyte of omentum tissue
def: "An adipocyte that is part of omentum tissue." [GOC:tfm]
subset: cellxgene_subset
synonym: "omental adipocyte" EXACT []
synonym: "omental fat cell" EXACT []
is_a: CL:0000136 {is_inferred="true"} ! adipocyte
intersection_of: CL:0000136 ! adipocyte
intersection_of: part_of UBERON:0003688 ! omentum
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0003688 ! omentum
creation_date: 2011-03-14T10:17:00Z
[Term]
id: CL:0002616
name: perirenal adipocyte
def: "An adipocyte of perirenal fat tissue." [GOC:tfm]
synonym: "perirenal adipocyte cell" EXACT []
synonym: "perirenal fat cell" EXACT []
is_a: CL:0000136 {is_inferred="true"} ! adipocyte
intersection_of: CL:0000136 ! adipocyte
intersection_of: part_of UBERON:0005406 ! perirenal fat
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0005406 ! perirenal fat
creation_date: 2011-03-14T10:17:05Z
[Term]
id: CL:0002617
name: adipocyte of breast
def: "An adipocyte that is part of the breast." [GOC:tfm]
comment: Adipocytes found in the subcutaneous adipose tissue of breast. The breast consists of three main components, the skin, the subcutaneous adipose tissue and the functional glandular tissue that comprises both parenchyma and stroma.[CALOHA]
subset: cellxgene_subset
synonym: "breast adipocyte" EXACT []
synonym: "fat cell of breast" EXACT []
xref: CALOHA:TS-2377
is_a: CL:0000136 {is_inferred="true"} ! adipocyte
intersection_of: CL:0000136 ! adipocyte
intersection_of: part_of UBERON:0000310 ! breast
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0000310 ! breast
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002617" xsd:string {name="adipocyte of breast on CELLxGENE CellGuide"}
creation_date: 2011-03-14T10:17:07Z
[Term]
id: CL:0002618
name: endothelial cell of umbilical vein
def: "An endothelial cell of the umbilical vein." [GOC:tfm]
xref: BTO:0004296
is_a: CL:0002543 ! vein endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0002066 ! umbilical vein
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002066 ! umbilical vein
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002618" xsd:string {name="endothelial cell of umbilical vein on CELLxGENE CellGuide"}
creation_date: 2011-03-14T11:36:51Z
[Term]
id: CL:0002620
name: skin fibroblast
def: "A fibroblast of skin." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
xref: BTO:0001255
xref: CALOHA:TS-0935
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0002097 ! skin of body
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002097 ! skin of body
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002620" xsd:string {name="skin fibroblast on CELLxGENE CellGuide"}
creation_date: 2011-03-14T12:31:49Z
[Term]
id: CL:0002621
name: gingival epithelial cell
def: "Any stratified squamous epithelial cell that is part of some gingival epithelium." [FBC:Autogenerated]
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:0000240 ! stratified squamous epithelial cell
is_a: CL:1001576 ! oral mucosa squamous cell
intersection_of: CL:0000240 ! stratified squamous epithelial cell
intersection_of: part_of UBERON:0001949 ! gingival epithelium
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001949 ! gingival epithelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2011-03-14T12:46:28Z
[Term]
id: CL:0002622
name: prostate stromal cell
def: "A stromal cell of the prostate." [GOC:tfm]
subset: cellxgene_subset
xref: BTO:0003972
is_a: CL:0000499 {is_inferred="true"} ! stromal cell
intersection_of: CL:0000499 ! stromal cell
intersection_of: part_of UBERON:0002367 ! prostate gland
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002367 ! prostate gland
creation_date: 2011-03-14T02:11:10Z
[Term]
id: CL:0002623
name: acinar cell of salivary gland
def: "An acinar cell that is part of the salivary gland epithelium, responsible for synthesizing and secreting the primary saliva essential for oral digestion, antimicrobial defense, and mucosal immunity. It features apical-basal polarity with apical secretory granules, and tight junctions that maintain polarity and regulate calcium-dependent saliva exocytosis triggered by parasympathetic and sympathetic signals (Ambudkar, 2015). This cell functions in coordination with contractile myoepithelial cells, which aid saliva flow through the ducts into the oral cavity (Khan et al., 2022). In mice and humans, acinar cell development relies on the transcription factor SOX2 (Emmerson et al., 2017), with self-renewal achieved primarily through acinar cell self-duplication and supported by progenitor populations during injury and regeneration (Aure et al., 2016)." [GOC:tfm, PMID:24646566, PMID:25843887, PMID:28623666, PMID:34989394, PMID:35343828]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "salivary acinar cell" EXACT [PMID:24646566]
synonym: "salivary gland acinar cell" EXACT [PMID:24646566]
is_a: CL:0000622 {is_inferred="true"} ! acinar cell
is_a: CL:1001596 ! salivary gland glandular cell
intersection_of: CL:0000622 ! acinar cell
intersection_of: part_of UBERON:0004809 ! salivary gland epithelium
relationship: capable_of GO:0017156 ! calcium-ion regulated exocytosis
relationship: capable_of GO:0045087 ! innate immune response
relationship: capable_of GO:0046541 ! saliva secretion
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: has_part GO:0030141 ! secretory granule
relationship: part_of UBERON:0004809 ! salivary gland epithelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002623" xsd:string {name="acinar cell of salivary gland on CELLxGENE CellGuide"}
creation_date: 2011-03-14T02:22:22Z
[Term]
id: CL:0002625
name: seminiferous tubule epithelial cell
def: "A cell of the seminiferous tubule epithelium." [GOC:tfm]
is_a: CL:0000068 ! duct epithelial cell
is_a: CL:0000077 {is_inferred="true"} ! mesothelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001343 ! seminiferous tubule of testis
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001343 ! seminiferous tubule of testis
relationship: part_of UBERON:0004813 ! seminiferous tubule epithelium
creation_date: 2011-03-15T11:59:23Z
[Term]
id: CL:0002631
name: epithelial cell of upper respiratory tract
def: "Any epithelial cell that is part of some upper respiratory tract epithelium." [FBC:Autogenerated]
is_a: CL:0002368 ! respiratory tract epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0004814 ! upper respiratory tract epithelium
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0004814 ! upper respiratory tract epithelium
creation_date: 2011-06-21T12:28:55Z
[Term]
id: CL:0002632
name: epithelial cell of lower respiratory tract
def: "Any epithelial cell that is part of some lower respiratory tract epithelium." [FBC:Autogenerated]
subset: cellxgene_subset
is_a: CL:0002368 ! respiratory tract epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0004815 ! lower respiratory tract epithelium
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0004815 ! lower respiratory tract epithelium
creation_date: 2011-06-21T12:29:31Z
[Term]
id: CL:0002633
name: respiratory basal cell
def: "A basal cell in the respiratory tract." [GOC:tfm, PMID:20699479]
subset: cellxgene_subset
synonym: "airway basal cell" EXACT []
synonym: "airway basal stem cell" EXACT []
is_a: CL:0000646 ! basal cell
intersection_of: CL:0000646 ! basal cell
intersection_of: part_of UBERON:0004802 ! respiratory tract epithelium
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0004802 ! respiratory tract epithelium
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002633" xsd:string {name="respiratory basal cell on CELLxGENE CellGuide"}
creation_date: 2011-06-21T03:11:10Z
[Term]
id: CL:0002634
name: epithelial cell of anal column
def: "An epithelial cell of the anal column." [GOC:tfm]
is_a: CL:0002253 ! epithelial cell of large intestine
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0009882 ! anal column
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0009882 ! anal column
creation_date: 2011-07-08T12:11:38Z
[Term]
id: CL:0002637
name: keratinized epithelial cell of the anal canal
def: "An epithelial cell of the anal canal that is keratinized. This cell type is found towards the lower, rectal end of the anal canal." [GOC:tfm]
is_a: CL:0000237 ! keratinizing barrier epithelial cell
is_a: CL:0002634 ! epithelial cell of anal column
intersection_of: CL:0000237 ! keratinizing barrier epithelial cell
intersection_of: part_of UBERON:0000159 ! anal canal
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0000159 ! anal canal
creation_date: 2011-07-08T02:08:40Z
[Term]
id: CL:0002651
name: endothelial cell of venous sinus of spleen
def: "An endothelial cell that is part of the venous sinus of spleen. This endothelial cell has an elongated, spindle-shaped, flattened morphology that is parallel to long axis of sinus. This cell type rests on a basement membrane interrupted by numerous narrow slits." [GOC:tfm]
synonym: "stave cell" EXACT [FMA:62817]
xref: FMA:72140
is_a: CL:0002262 ! endothelial cell of sinusoid
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-07-08T03:06:49Z
[Term]
id: CL:0002652
name: endothelial cell of high endothelial venule
def: "A venule endothelial cell that is cubodial, expresses leukocyte-specific receptors, and allows for passage of lymphocytes into bloodstream." [GOC:tfm, PMID:20726857]
comment: Markers expressed on HEV include: MAdCAM-1,PNAd (sulfated and glycosylated molecules, i.e. GlyCAM-1, CD34, endomucin, nepmucin), ICAM-1, ICAM-2,Fuc-TVII, beta 3GlcNAcT-3, GlcNAc6ST2,CCL21, CCL19, CXCL13, CXCL12, Autotaxin, DARC, angiomodulin, LRHG.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "endothelial cell of postcapillary venule of lymph node" BROAD []
synonym: "HEV cell" EXACT []
xref: FMA:67759
is_a: CL:1000414 ! endothelial cell of venule
intersection_of: CL:0002139 ! endothelial cell of vascular tree
intersection_of: part_of UBERON:8410037 ! high endothelial venule
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:8410037 ! high endothelial venule
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2011-07-08T03:14:10Z
[Term]
id: CL:0002653
name: squamous endothelial cell
def: "A squamous shaped endothelial cell." [GOC:dos]
is_a: CL:0000115 ! endothelial cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-07-08T03:31:25Z
[Term]
id: CL:0002656
name: glandular endometrial unciliated epithelial cell
def: "A glandular epithelial cell of the endometrium. Following ovulation, these cells secrete a glycogen-rich substance known as histotroph or uterine milk, which nourishes the embryo if implantation occurs." [GOC:tfm, PMID:25023676]
synonym: "glandular cell of endometrium" BROAD []
xref: FMA:86489
is_a: CL:0000150 ! glandular secretory epithelial cell
is_a: CL:0000152 ! exocrine cell
is_a: CL:0009084 ! glandular epithelial cell of endometrium
is_a: CL:1001591 ! oviduct secretory cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: capable_of GO:0032940 ! secretion by cell
intersection_of: part_of UBERON:0002451 ! endometrial gland
relationship: capable_of GO:0032940 ! secretion by cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002451 ! endometrial gland
creation_date: 2011-07-08T03:54:08Z
[Term]
id: CL:0002657
name: glandular cell of esophagus
def: "A glandular epithelial cell of the esophagus." [GOC:tfm]
subset: cellxgene_subset
xref: FMA:86548
is_a: CL:0000150 {is_inferred="true"} ! glandular secretory epithelial cell
is_a: CL:0002252 {is_inferred="true"} ! epithelial cell of esophagus
intersection_of: CL:0000150 ! glandular secretory epithelial cell
intersection_of: part_of UBERON:0001976 ! epithelium of esophagus
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001976 ! epithelium of esophagus
creation_date: 2011-07-08T03:55:57Z
[Term]
id: CL:0002658
name: glandular cell of the large intestine
def: "A glandular epithelial cell of the large intestine." [GOC:tfm]
xref: FMA:87194
is_a: CL:0000150 {is_inferred="true"} ! glandular secretory epithelial cell
is_a: CL:0002253 ! epithelial cell of large intestine
intersection_of: CL:0000150 ! glandular secretory epithelial cell
intersection_of: part_of UBERON:0000059 ! large intestine
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0000059 ! large intestine
creation_date: 2011-07-08T04:03:01Z
[Term]
id: CL:0002659
name: glandular epithelial cell of stomach
def: "A glandular epithelial cell that is part of the stomach." [GOC:tfm]
synonym: "glandular cell of stomach" EXACT []
xref: CALOHA:TS-1284
xref: FMA:86554
is_a: CL:0000150 ! glandular secretory epithelial cell
is_a: CL:0002178 ! epithelial cell of stomach
intersection_of: CL:0000150 ! glandular secretory epithelial cell
intersection_of: part_of UBERON:0001276 ! epithelium of stomach
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001276 ! epithelium of stomach
creation_date: 2011-07-11T01:20:35Z
[Term]
id: CL:0002663
name: myocardial endocrine cell of atrium
def: "A myocardial endocrine cell that is part of the atrium." [GOC:tfm]
xref: FMA:83389
is_a: CL:0002074 {is_inferred="true"} ! myocardial endocrine cell
intersection_of: CL:0002074 ! myocardial endocrine cell
intersection_of: part_of UBERON:0002081 ! cardiac atrium
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002081 ! cardiac atrium
creation_date: 2011-07-11T02:45:39Z
[Term]
id: CL:0002664
name: cardioblast
def: "A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart." [GOC:tfm, PMID:19745164]
comment: Discrepancy in develops from origins prevents me from making the assertion that cardioblasts give rise to all instances of cardiocytes as we state cardiac muscle cells develop from cardiac myoblast, which in turn develop from muscle stem cell.
synonym: "cardiovascular progenitor cell" EXACT [PMID:17519333, PMID:19745164]
synonym: "CPC" RELATED OMO:0003000 [PMID:19745164]
is_a: CL:0000048 ! multi fate stem cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-07-11T03:15:38Z
[Term]
id: CL:0002665
name: otic fibrocyte
def: "A mesenchymal cell within the inner ear, specifically localised to supportive connective tissues such as the spiral ligament and spiral limbus. This cell has specialised structural and molecular adaptations, and it contributes to the homeostasis of the cochlear environment by participating in ionic regulation crucial for auditory function." [GOC:tfm, PMID:18353863, PMID:37720106]
synonym: "cochlear fibrocyte" NARROW [PMID:34436572]
is_a: CL:0008019 ! mesenchymal cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001846 ! internal ear
creation_date: 2011-07-11T03:35:01Z
[Term]
id: CL:0002672
name: retinal progenitor cell
def: "A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells." [GOC:tfm, PMID:20959166, PMID:21148186]
subset: cellxgene_subset
is_a: CL:0000048 ! multi fate stem cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0000133 ! neurectodermal cell
creation_date: 2011-08-16T02:38:01Z
[Term]
id: CL:0002673
name: tongue muscle cell
def: "A skeletal muscle cell that is part of the tongue." [GOC:tfm, PMID:18816858]
subset: cellxgene_subset
is_a: CL:0008002 ! skeletal muscle fiber
intersection_of: CL:0008002 ! skeletal muscle fiber
intersection_of: part_of UBERON:0000378 ! tongue muscle
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0000378 ! tongue muscle
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002673" xsd:string {name="tongue muscle cell on CELLxGENE CellGuide"}
creation_date: 2011-08-16T03:10:02Z
[Term]
id: CL:0002676
name: neural crest derived neuroblast
def: "A neuroblast derived from a neural crest cell." [GOC:tfm, PMID:17407019]
is_a: CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0000333 ! migratory neural crest cell
creation_date: 2011-08-22T09:24:15Z
[Term]
id: CL:0002680
name: PP cell of intestine
def: "A PP cell found in intestine." [GOC:tfm, PMID:2420136, PMID:728970]
is_a: CL:0000696 {is_inferred="true"} ! PP cell
is_a: CL:1001516 ! intestinal enteroendocrine cell
intersection_of: CL:0000696 ! PP cell
intersection_of: part_of UBERON:0001277 ! intestinal epithelium
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001277 ! intestinal epithelium
creation_date: 2011-09-27T11:59:01Z
[Term]
id: CL:0002681
name: kidney cortical cell
def: "A cell that is part of a cortex of kidney." []
is_a: CL:1000497 ! kidney cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0001225 ! cortex of kidney
relationship: dc-contributor https://orcid.org/0000-0002-0956-8634
relationship: part_of UBERON:0001225 ! cortex of kidney
creation_date: 2011-10-25T03:49:41Z
[Term]
id: CL:0005000
name: spinal cord interneuron
def: "A CNS interneuron located in the spinal cord." [CL:CVS]
comment: Is_a interneuron, part_of UBERON:0002240.
xref: ZFA:0000778 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000099 {is_inferred="true"} ! interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0002100 UBERON:0002240 ! has soma location spinal cord
relationship: RO:0002100 UBERON:0002240 ! has soma location spinal cord
[Term]
id: CL:0005001
name: iridoblast
def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into an iridophore." [CL:CVS]
comment: Derived from UBERON:0002342 neural crest.
xref: ZFA:0005328 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0011026 ! progenitor cell
relationship: develops_from CL:0000333 ! migratory neural crest cell
[Term]
id: CL:0005002
name: xanthoblast
def: "A non-terminally differentiated cell that differentiates into a xanthophore." [CL:CVS]
xref: ZFA:0005245 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0011026 ! progenitor cell
relationship: develops_from CL:0000333 ! migratory neural crest cell
[Term]
id: CL:0005004
name: pigment erythroblast
def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into an erythrophore." [CL:CVS]
xref: ZFA:0005331 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0011026 ! progenitor cell
relationship: develops_from CL:0000333 ! migratory neural crest cell
[Term]
id: CL:0005006
name: ionocyte
def: "Specialized epithelial cells involved in the maintenance of osmotic homeostasis. They are characterized by abundant mitochondria and ion transporters. In amniotes, they are present in the renal system. In freshwater fish, ionocytes in the skin and gills help maintain osmotic homeostasis by absorbing salt from the external environment." [PMID:17555741, PMID:19268451]
subset: cellxgene_subset
subset: human_reference_atlas
xref: ZFA:0005323 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000066 ! epithelial cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0005006" xsd:string {name="ionocyte on CELLxGENE CellGuide"}
[Term]
id: CL:0005007
name: Kolmer-Agduhr neuron
def: "Kolmer-Agduhr neurons are ciliated GABAergic neurons that contact the central canal of the spinal cord and have ipsilateral ascending axons." [PMID:18680739]
synonym: "KA cell" EXACT []
synonym: "KA interneuron" EXACT [PMID:15539490]
synonym: "KA neuron" EXACT [PMID:9634146]
synonym: "Kolmer-Agduhr cell" EXACT []
xref: ZFA:0005240 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0005000 ! spinal cord interneuron
is_a: CL:0011005 ! GABAergic interneuron
[Term]
id: CL:0005008
name: macular hair cell
def: "An auditory hair cell located in the macula that is sensitive to auditory stimuli." [GO:cvs]
is_a: CL:0000202 ! auditory hair cell
is_a: CL:0002374 ! ear hair cell
intersection_of: CL:0000202 ! auditory hair cell
intersection_of: part_of UBERON:0000054 ! macula
relationship: part_of UBERON:0000054 ! macula
[Term]
id: CL:0005009
name: renal principal cell
def: "A cuboidal epithelial cell of the kidney which regulates sodium and potassium balance. The activity of sodium and potassium channels on the apical membrane of the cell is regulated by aldosterone and vasopressin. In mammals this cell type is located in the renal collecting duct system." [CL:CVS]
subset: cellxgene_subset
xref: ZFA:0005322 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
is_a: CL:0002518 ! kidney epithelial cell
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0005009" xsd:string {name="renal principal cell on CELLxGENE CellGuide"}
[Term]
id: CL:0005012
name: multiciliated epithelial cell
def: "A columnar/cuboidal epithelial cell with multiple motile cilia on its apical surface. These cells facilitate the movement of liquids such as mucus or cerebrospinal fluid across the epithelial surface." [CL:CVS, PMID:28400610, PMID:30422572, PMID:38032388]
comment: While the term 'multi-ciliated epithelial cell' refers to cells with multiple motile cilia, there are exceptions where epithelial cells may have multiple non-motile cilia. Examples include olfactory sensory neurons, which have non-motile cilia for sensory detection, and choroid plexus epithelial cells, which possess multiple non-motile cilia with transient motility during development. Multiciliated cells are essential for human health, and their dysfunction can lead to various diseases known as ciliopathies, such as primary ciliary dyskinesia. This condition affects the respiratory system, brain ventricles, and reproductive system, leading to chronic respiratory infections, hydrocephalus, and infertility {xref="PMID:22118931", xref="PMID:23959957", xref="PMID:26378583", xref="PMID:25729351"}
subset: cellxgene_subset
synonym: "MCC" RELATED OMO:0003000 []
synonym: "multi-ciliated cell" BROAD []
synonym: "multi-ciliated epithelial cell" EXACT []
synonym: "multiciliated cell" BROAD []
synonym: "multiciliated epithelial cell" EXACT []
xref: ZFA:0005242 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000067 ! ciliated epithelial cell
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell
intersection_of: has_part GO:0031514 ! motile cilium
intersection_of: RO:0000053 PATO:0010007 ! has characteristic multiciliated
relationship: has_part GO:0031514 ! motile cilium
relationship: RO:0000053 PATO:0010007 ! has characteristic multiciliated
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0005012" xsd:string {name="multiciliated epithelial cell on CELLxGENE CellGuide"}
[Term]
id: CL:0005014
name: auditory epithelial supporting cell
def: "A non-sensory cell that extends from the basement membrane to the apical surface of the auditory epithelium and provides support for auditory hair cells." [CL:CVS, GOC:tfm]
synonym: "auditory epithelial support cell" EXACT []
xref: ZFA:0005244 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000630 ! supporting cell
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:0002491 ! auditory epithelial cell
[Term]
id: CL:0005020
name: lymphangioblast
def: "Lymphatic progenitor cells." [CL:CVS]
comment: Usually express Prox1, or prox1b.
xref: ZFA:0009393 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell
is_a: CL:4033054 ! perivascular cell
intersection_of: CL:0000048 ! multi fate stem cell
intersection_of: adjacent_to UBERON:0004536 ! lymph vasculature
relationship: adjacent_to UBERON:0004536 ! lymph vasculature
relationship: dc-contributor https://orcid.org/0000-0002-2244-7917
creation_date: 2012-01-12T04:44:34Z
[Term]
id: CL:0005022
name: vascular lymphangioblast
def: "Lymphatic progenitor cells, derived from the veins, that give rise to lymphatic endothelial cells." [CL:CVS]
subset: cellxgene_subset
synonym: "parachordal lymphangioblast" NARROW []
xref: ZFA:0009395 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0005020 {is_inferred="true"} ! lymphangioblast
intersection_of: CL:0005020 ! lymphangioblast
intersection_of: adjacent_to UBERON:0001638 ! vein
relationship: adjacent_to UBERON:0001638 ! vein
relationship: dc-contributor https://orcid.org/0000-0002-2244-7917
creation_date: 2012-01-12T05:21:09Z
[Term]
id: CL:0005024
name: somatomotor neuron
def: "A motor neuron that innervates a skeletal muscle. These motor neurons are all excitatory and cholinergic." [ZFIN:CVS]
synonym: "somatic motor neuron" EXACT []
xref: ZFA:0005733 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000100 ! motor neuron
is_a: CL:0000108 ! cholinergic neuron
intersection_of: CL:0000100 ! motor neuron
intersection_of: RO:0002120 CL:0008002 ! synapsed to skeletal muscle fiber
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: part_of RO:0002577 ! system
relationship: RO:0002120 CL:0008002 ! synapsed to skeletal muscle fiber
[Term]
id: CL:0005026
name: hepatoblast
def: "Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation." [GOC:CVS, https://orcid.org/0000-0003-1940-6740, PMID:18356246, PMID:20483998, PMID:26798363]
subset: cellxgene_subset
is_a: CL:0000048 ! multi fate stem cell
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0005026" xsd:string {name="hepatoblast on CELLxGENE CellGuide"}
property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/800" xsd:string
[Term]
id: CL:0007000
name: preameloblast
def: "Skeletogenic cell that has the potential to develop into an ameloblast. Located in the inner enamel epithelium, these cells elongate, their nuclei shift distally (away from the dental papilla), and their cytoplasm becomes filled with organelles needed for synthesis and secretion of enamel proteins." [GO_REF:0000034, PMCID:PMC2737325]
comment: unsure of neural crest contribution. In VSAO we have develops_from CL:0000008
is_a: CL:0011026 ! progenitor cell
relationship: adjacent_to UBERON:0001763 ! odontogenic papilla
relationship: dc-contributor https://orcid.org/0000-0001-9114-8737
relationship: develops_from CL:0002077 ! ecto-epithelial cell
relationship: part_of UBERON:0005176 ! tooth enamel organ
creation_date: 2012-06-15T01:27:01Z
[Term]
id: CL:0007001
name: skeletogenic cell
def: "Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized)." [GO_REF:0000034]
comment: Needs logical definition. Should be capable_of skeletal system morphogenesis? or skeletal tissue development? needs to be added to GO. NOTES:a cell type of the early embryo (see also: mesenchymal cells) that will give rise to mineralized connective tissue. Scleroblasts can differentiate into osteoblasts (bone-forming cells), chondroblasts (cartilage-forming cells), odontoblasts (dentin-forming cells), ameloblasts (enamel-forming cells). The mesenchymal cells developing into osteoblasts and chondroblasts are derived from the mesoderm. Those developing into odontoblasts are neural crest cells. Those developing into ameloblasts are derived from the ectoderm. (http://www.copewithcytokines.de/cope.cgi?key=scleroblasts)
synonym: "scleroblast" EXACT [GO_REF:0000034]
is_a: CL:0000000 ! cell
relationship: dc-contributor https://orcid.org/0000-0001-9114-8737
creation_date: 2012-06-15T02:51:27Z
[Term]
id: CL:0007002
name: precementoblast
def: "Skeletogenic cell that has the potential to develop into a cementoblast." [GO_REF:0000034]
is_a: CL:0011026 ! progenitor cell
relationship: dc-contributor https://orcid.org/0000-0001-9114-8737
relationship: part_of UBERON:0005176 ! tooth enamel organ
creation_date: 2012-06-15T04:37:13Z
[Term]
id: CL:0007003
name: preodontoblast
def: "Skeletogenic cell that has the potential to form an odontoblast, deposits predentine, and arises from a cranial neural crest cell." [GO_REF:0000034]
is_a: CL:0011026 ! progenitor cell
relationship: dc-contributor https://orcid.org/0000-0001-9114-8737
relationship: develops_from CL:0000008 ! migratory cranial neural crest cell
relationship: part_of UBERON:0005176 ! tooth enamel organ
creation_date: 2012-06-15T05:15:11Z
[Term]
id: CL:0007004
name: premigratory neural crest cell
def: "Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells." [UBERONREF:0000002]
subset: cellxgene_subset
xref: ZFA:0007084 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0011012 ! neural crest cell
relationship: dc-contributor https://orcid.org/0000-0001-9114-8737
relationship: develops_from CL:0000133 ! neurectodermal cell
relationship: part_of UBERON:0002342 ! neural crest
creation_date: 2012-06-27T08:27:35Z
[Term]
id: CL:0007005
name: notochordal cell
def: "Cell that is part of the notochord." [GO_REF:0000034]
comment: NOTE: TO DO, notochord development still needs work.
subset: cellxgene_subset
is_a: CL:0000255 ! eukaryotic cell
relationship: dc-contributor https://orcid.org/0000-0001-9114-8737
relationship: develops_from CL:0007006 ! chordamesodermal cell
relationship: part_of UBERON:0002328 ! notochord
creation_date: 2012-06-27T08:47:31Z
[Term]
id: CL:0007006
name: chordamesodermal cell
def: "Mesodermal cell that is axially located and gives rise to the cells of the notochord." [GO_REF:0000034]
synonym: "axial mesodermal cell" EXACT []
is_a: CL:0000222 ! mesodermal cell
relationship: dc-contributor https://orcid.org/0000-0001-9114-8737
relationship: part_of UBERON:0004880 ! chordamesoderm
creation_date: 2012-06-27T08:52:41Z
[Term]
id: CL:0007008
name: notochordal vacuole cell
def: "Notochordal cell that is inner portion of the notochord and becomes vacuolated as development proceeds." [CL:MAH]
synonym: "chordablast" EXACT [GO_REF:0000034]
synonym: "chordoblast" EXACT [PMID:14574572]
is_a: CL:0007005 ! notochordal cell
relationship: dc-contributor https://orcid.org/0000-0001-9114-8737
creation_date: 2012-06-27T09:29:30Z
[Term]
id: CL:0007009
name: prechondroblast
def: "Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells." [GO_REF:0000034]
is_a: CL:0011026 ! progenitor cell
relationship: dc-contributor https://orcid.org/0000-0001-9114-8737
creation_date: 2012-06-27T10:44:01Z
[Term]
id: CL:0007010
name: preosteoblast
def: "Skeletogenic cell that has the potential to transform into an osteoblast, and develops from neural crest or mesodermal cells." [GO_REF:0000034]
subset: cellxgene_subset
synonym: "osteoprogenitor cell" EXACT []
is_a: CL:0001035 ! bone cell
is_a: CL:0002320 ! connective tissue cell
is_a: CL:0011026 ! progenitor cell
relationship: dc-contributor https://orcid.org/0000-0001-9114-8737
relationship: develops_from CL:0000222 ! mesodermal cell
relationship: develops_from CL:0000333 ! migratory neural crest cell
relationship: part_of UBERON:0008883 ! osteoid
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0007010" xsd:string {name="preosteoblast on CELLxGENE CellGuide"}
creation_date: 2012-06-27T10:57:21Z
[Term]
id: CL:0007011
name: enteric neuron
def: "Neuron that is part of the enteric nervous system." [CL:MAH]
subset: cellxgene_subset
xref: ZFA:0005775 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000029 ! neural crest derived neuron
is_a: CL:0000107 ! autonomic neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0002005 ! has soma location enteric nervous system
relationship: dc-contributor https://orcid.org/0000-0001-9114-8737
relationship: develops_from CL:0002607 ! migratory enteric neural crest cell
relationship: part_of UBERON:0002005 ! enteric nervous system
relationship: RO:0002100 UBERON:0002005 ! has soma location enteric nervous system
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0007011" xsd:string {name="enteric neuron on CELLxGENE CellGuide"}
creation_date: 2012-06-28T08:20:31Z
[Term]
id: CL:0008000
name: non-striated muscle cell
def: "Any muscle cell in which the fibers are not organised into sarcomeres." [GOC:DOS]
is_a: CL:0000187 ! muscle cell
[Term]
id: CL:0008001
name: hematopoietic precursor cell
def: "Any hematopoietic cell that is a precursor of some other hematopoietic cell type." [GOC:dos]
subset: cellxgene_subset
is_a: CL:0000988 ! hematopoietic cell
[Term]
id: CL:0008002
name: skeletal muscle fiber
def: "A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:tfm, ISBN:0323052908]
subset: cellxgene_subset
xref: MESH:D018485
is_a: CL:0000188 ! cell of skeletal muscle
is_a: CL:0002372 ! myotube
intersection_of: CL:0000187 ! muscle cell
intersection_of: has_part GO:0030017 ! sarcomere
intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue
intersection_of: RO:0000053 PATO:0001908 ! has characteristic multinucleate
intersection_of: RO:0000053 PATO:0002478 ! has characteristic transversely striated
relationship: develops_from CL:0000515 ! skeletal muscle myoblast
relationship: has_part GO:0030017 ! sarcomere
relationship: part_of UBERON:0001134 ! skeletal muscle tissue
relationship: RO:0000053 PATO:0001908 ! has characteristic multinucleate
relationship: RO:0000053 PATO:0002478 ! has characteristic transversely striated
[Term]
id: CL:0008003
name: somatic muscle myotube
def: "A myotube that is part of some somatic muscle. Examples include arthropod somatic muscle cells." [PMID:22274696, PMID:8720463]
is_a: CL:0002372 ! myotube
is_a: CL:0008004 ! somatic muscle cell
intersection_of: CL:0008004 ! somatic muscle cell
intersection_of: has_part GO:0030017 ! sarcomere
intersection_of: RO:0000053 PATO:0001908 ! has characteristic multinucleate
intersection_of: RO:0000053 PATO:0002478 ! has characteristic transversely striated
relationship: has_part GO:0030017 ! sarcomere
relationship: RO:0000053 PATO:0001908 ! has characteristic multinucleate
relationship: RO:0000053 PATO:0002478 ! has characteristic transversely striated
[Term]
id: CL:0008004
name: somatic muscle cell
def: "A muscle cell that is part of some somatic muscle." [GOC:dos]
xref: FBbt:00005073 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
is_a: CL:0000187 ! muscle cell
[Term]
id: CL:0008005
name: obliquely striated somatic muscle cell
def: "A somatic muscle cell that is obliquely striated and mononucleated. Examples include the somatic muscles of nematodes." [doi:10.3908/wormatlas.1.7, PMID:8720463]
is_a: CL:0000226 ! single nucleate cell
is_a: CL:0000444 ! obliquely striated muscle cell
is_a: CL:0008004 ! somatic muscle cell
intersection_of: CL:0008004 ! somatic muscle cell
intersection_of: has_part GO:0030017 ! sarcomere
intersection_of: RO:0000053 PATO:0001407 ! has characteristic mononucleate
intersection_of: RO:0000053 PATO:0002479 ! has characteristic obliquely striated
relationship: has_part GO:0030017 ! sarcomere
relationship: RO:0000053 PATO:0001407 ! has characteristic mononucleate
relationship: RO:0000053 PATO:0002479 ! has characteristic obliquely striated
[Term]
id: CL:0008007
name: visceral muscle cell
def: "A muscle cell that is part of some visceral muscle." [GOC:dos]
xref: FBbt:00005070 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
is_a: CL:0000187 ! muscle cell
intersection_of: CL:0000187 ! muscle cell
intersection_of: part_of UBERON:8600004 ! visceral muscle tissue
relationship: part_of UBERON:8600004 ! visceral muscle tissue
[Term]
id: CL:0008008
name: striated visceral muscle cell
def: "A visceral muscle cell that is striated. Examples include the visceral muscle cells of arhtropods." [GOC:dos]
is_a: CL:0000737 ! striated muscle cell
is_a: CL:0008007 ! visceral muscle cell
intersection_of: CL:0008007 ! visceral muscle cell
intersection_of: RO:0000053 PATO:0001410 {all_some="true"} ! has characteristic striated
relationship: has_part GO:0030017 ! sarcomere
relationship: RO:0000053 PATO:0001410 ! has characteristic striated
[Term]
id: CL:0008009
name: transversely striated visceral muscle cell
def: "A visceral muscle that is transversely striated. Examples include the visceral muscle cells of arthropods." [GOC:dos]
is_a: CL:0008008 ! striated visceral muscle cell
intersection_of: CL:0008007 ! visceral muscle cell
intersection_of: RO:0000053 PATO:0002478 {all_some="true"} ! has characteristic transversely striated
relationship: has_part GO:0030017 ! sarcomere
relationship: RO:0000053 PATO:0002478 ! has characteristic transversely striated
[Term]
id: CL:0008017
name: adult skeletal muscle myoblast
def: "A skeletal muscle myoblast that is part of a skeletal mucle. These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers." [PMID:23303905]
comment: The vast majority of these cells develop from skeletal muscle satellite cells, although there are some reports of other origins.
subset: cellxgene_subset
synonym: "myogenic precursor cell" BROAD [PMID:23303905]
is_a: CL:0000188 ! cell of skeletal muscle
is_a: CL:0000515 ! skeletal muscle myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: develops_into CL:0008002 ! skeletal muscle fiber
intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue
relationship: develops_into CL:0008002 ! skeletal muscle fiber
relationship: part_of UBERON:0001134 ! skeletal muscle tissue
[Term]
id: CL:0008018
name: somatic muscle myoblast
def: "A myoblast that is commited to developing into a somatic muscle." []
is_a: CL:0000056 ! myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: develops_into CL:0008003 ! somatic muscle myotube
relationship: develops_into CL:0008003 ! somatic muscle myotube
[Term]
id: CL:0008019
name: mesenchymal cell
def: "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration." []
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "mesenchyme cell" EXACT []
is_a: CL:0000219 ! motile cell
is_a: CL:0000255 ! eukaryotic cell
relationship: capable_of GO:0016477 ! cell migration
relationship: part_of UBERON:0003104 ! mesenchyme
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0008019" xsd:string {name="mesenchymal cell on CELLxGENE CellGuide"}
[Term]
id: CL:0008021
name: anterior lateral line ganglion neuron
def: "Any peripheral nervous system neuron that has its soma located in some anterior lateral line ganglion." [FBC:Autogenerated]
is_a: CL:2000031 ! lateral line ganglion neuron
intersection_of: CL:2000032 ! peripheral nervous system neuron
intersection_of: RO:0002100 UBERON:2001391 ! has soma location anterior lateral line ganglion
relationship: RO:0002100 UBERON:2001391 ! has soma location anterior lateral line ganglion
[Term]
id: CL:0008022
name: endocardial cushion cell
def: "A mesenchymal cell of the endocardial cushion. These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves." [PMID:18816864]
is_a: CL:0000569 ! cardiac mesenchymal cell
is_a: CL:0002494 ! cardiocyte
intersection_of: CL:0000569 ! cardiac mesenchymal cell
intersection_of: part_of UBERON:0002062 ! endocardial cushion
relationship: part_of UBERON:0002062 ! endocardial cushion
[Term]
id: CL:0008024
name: pancreatic endocrine cell
def: "An endocrine cell that is part of the pancreas." [GOC:dos]
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:0000083 ! epithelial cell of pancreas
is_a: CL:0000164 ! enteroendocrine cell
intersection_of: CL:0000163 ! endocrine cell
intersection_of: part_of UBERON:0001264 ! pancreas
relationship: part_of UBERON:0001264 ! pancreas
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0008025
name: noradrenergic neuron
def: "A neuron that release noradrenaline (noriphinephrine) as a neurotransmitter." [GOC:dos]
xref: ZFA:0005873 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000459 ! noradrenergic cell
is_a: CL:4033050 ! catecholaminergic neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0061533 ! norepinephrine secretion, neurotransmission
relationship: capable_of GO:0061533 ! norepinephrine secretion, neurotransmission
[Term]
id: CL:0008026
name: open tracheal system tracheocyte
def: "An epithelial cell that is part of the epithelium of a tracheal tube in an open tracheal system, such as that found in insects." [GOC:dos]
xref: FBbt:00005038 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0003127 ! open tracheal system trachea
relationship: part_of UBERON:0003127 ! open tracheal system trachea
[Term]
id: CL:0008028
name: visual system neuron
def: "Any neuron that is capable of part of some visual perception." [FBC:Autogenerated]
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of_part_of GO:0007601 ! visual perception
relationship: capable_of_part_of GO:0007601 ! visual perception
relationship: dc-contributor https://orcid.org/0000-0002-7073-9172
creation_date: 2017-07-09T19:12:36Z
[Term]
id: CL:0008031
name: cortical interneuron
def: "An interneuron that has its soma located in the cerebral cortex." []
subset: cellxgene_subset
synonym: "cerebral cortex interneuron" EXACT []
is_a: CL:0000099 ! interneuron
is_a: CL:0010012 ! cerebral cortex neuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
relationship: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0008031" xsd:string {name="cortical interneuron on CELLxGENE CellGuide"}
[Term]
id: CL:0008033
name: decidual pericyte
def: "A pericyte of the decidual vasculature." [PMID:30429548]
subset: added_for_HCA
synonym: "decidual perivascular cell" EXACT []
is_a: CL:0000349 ! extraembryonic cell
is_a: CL:2000078 ! placental pericyte
intersection_of: CL:0000669 ! pericyte
intersection_of: part_of UBERON:0002450 ! decidua
relationship: dc-contributor https://orcid.org/0000-0002-7073-9172
relationship: part_of UBERON:0002450 ! decidua
creation_date: 2020-02-29T11:45:57Z
[Term]
id: CL:0008034
name: mural cell
def: "Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation." [Wiki:Mural_cell&oldid=930603194]
subset: added_for_HCA
subset: cellxgene_subset
subset: human_reference_atlas
xref: ZFA:0005944 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:4033054 ! perivascular cell
relationship: dc-contributor https://orcid.org/0000-0002-7073-9172
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2020-02-29T17:33:55Z
[Term]
id: CL:0008035
name: microcirculation associated smooth muscle cell
def: "Any vascular associated smooth muscle cell that is part of some microcirculatory vessel." [FBC:Autogenerated]
subset: cellxgene_subset
is_a: CL:0000359 ! vascular associated smooth muscle cell
is_a: CL:0008034 ! mural cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: part_of UBERON:0010523 ! microcirculatory vessel
relationship: dc-contributor https://orcid.org/0000-0002-7073-9172
relationship: part_of UBERON:0010523 ! microcirculatory vessel
creation_date: 2020-02-29T17:37:00Z
[Term]
id: CL:0008038
name: alpha motor neuron
def: "A large, multipolar lower motor neuron of the brainstem and spinal cord that innervates the extrafusal muscle fibers of skeletal muscle and are directly responsible for initiating their contraction. While their cell bodies are in the CNS (in the anterior gray horn of the spinal cord), they are part of the somatic nervous system - a branch of the PNS." [DOI:10.1016/B978-0-12-801238-3.05364-2, Wikipedia:Alpha_motor_neuron&oldid=957148643]
synonym: "alpha motoneuron" EXACT []
is_a: CL:0008039 ! lower motor neuron
relationship: dc-contributor https://orcid.org/0000-0002-7073-9172
relationship: RO:0002120 CL:0008046 ! synapsed to extrafusal muscle fiber
creation_date: 2020-09-23T20:16:26Z
[Term]
id: CL:0008039
name: lower motor neuron
def: "The motor neurons of vertebrates that directly innervate skeletal muscles. They receive input from upper motor neurons." [Wikipedia:Lower_motor_neuron&oldid=952547294]
xref: FMA:84632
is_a: CL:0005024 ! somatomotor neuron
relationship: dc-contributor https://orcid.org/0000-0002-7073-9172
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
creation_date: 2020-09-23T20:22:07Z
[Term]
id: CL:0008041
name: mesothelial cell of intestine
def: "A mesothelial cell that is part of the intestinal serosa." [https://orcid.org/0000-0002-7073-9172]
is_a: CL:0000077 ! mesothelial cell
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0001243 ! serosa of intestine
relationship: dc-contributor https://orcid.org/0000-0002-7073-9172
relationship: part_of UBERON:0001243 ! serosa of intestine
property_value: dcterms-date "2025-02-04T18:42:26Z" xsd:dateTime
[Term]
id: CL:0008046
name: extrafusal muscle fiber
def: "A skeletal muscle fiber that is innervated by alpha motor neuron and generates tension by contracting, thereby allowing for skeletal movement. These fibers make up the large mass of skeletal muscle tissue and are attached to bones by tendons." [DOI:10.1016/B978-0-443-10321-6.00004-7, Wikipedia:Extrafusal_muscle_fiber&oldid=978415293]
subset: cellxgene_subset
synonym: "myofibra extrafusalis" EXACT []
xref: TH:H3.03.00.0.00007
is_a: CL:0008002 ! skeletal muscle fiber
disjoint_from: CL:0008047 ! intrafusal muscle fiber
relationship: dc-contributor https://orcid.org/0000-0002-7073-9172
relationship: synapsed_by CL:0008038 ! alpha motor neuron
creation_date: 2020-09-26T21:06:15Z
[Term]
id: CL:0008047
name: intrafusal muscle fiber
def: "A skeletal muscle fiber that is part of a muscle spindle. These are specialized muscle fibers that serve as proprioceptors, detecting the amount and rate of change in length of a muscle. They are innervated by both sensory neurons and motor neurons (gamma and beta motorneurons, collectively referred to as fusimotor neurons)." [DOI:10.1016/B978-0-443-10321-6.00004-7, Wikipedia:Intrafusal_muscle_fiber&oldid=937508784]
synonym: "myofibra intrafusalis" EXACT []
xref: TH:H3.03.00.0.00012
is_a: CL:0002319 ! neural cell
is_a: CL:0008002 ! skeletal muscle fiber
intersection_of: CL:0008002 ! skeletal muscle fiber
intersection_of: part_of UBERON:0003718 ! muscle spindle
relationship: dc-contributor https://orcid.org/0000-0002-7073-9172
relationship: part_of UBERON:0003718 ! muscle spindle
creation_date: 2020-09-26T21:07:01Z
[Term]
id: CL:0008053
name: circumventricular organ capillary endothelial cell
def: "A capillary endothelial cell that is part of the circumventricular organs (CVOs), characterized by fenestrations that facilitate selective permeability to molecules, distinguishing it from the non-fenestrated endothelial cells of the blood-brain barrier. This cell is integral to the unique vascular structure of CVOs, which lack a traditional blood-brain barrier. It enables bidirectional exchange of polar molecules between blood and neural tissue, supporting neuroendocrine signaling, fluid balance, and immune responses. It is marked by the expression of PLVAP, a component of the fenestral diaphragm, in both rodents and humans." [PMID:26578857, PMID:35726097]
is_a: CL:0000666 ! fenestrated endothelial cell
is_a: CL:0002144 ! capillary endothelial cell
is_a: CL:2000044 ! brain microvascular endothelial cell
intersection_of: CL:0002144 ! capillary endothelial cell
intersection_of: part_of UBERON:0005408 ! circumventricular organ
relationship: dc-contributor https://orcid.org/0000-0002-7073-9172
relationship: part_of UBERON:0005408 ! circumventricular organ
property_value: dcterms-date "2025-03-14T12:44:38Z" xsd:dateTime
[Term]
id: CL:0008055
name: respiratory tract secretory epithelial cell
def: "A secretory epithelial cell of the respiratory tract epithelium. These cells have an endodermal origin." [DOI:10.1038/s41591-023-02327-2.]
is_a: CL:0002368 ! respiratory tract epithelial cell
is_a: CL:1100001 ! secretory epithelial cell
intersection_of: CL:1100001 ! secretory epithelial cell
intersection_of: part_of UBERON:0004802 ! respiratory tract epithelium
relationship: part_of UBERON:0004802 ! respiratory tract epithelium
property_value: dc-contributor "https://orcid.org/0000-0002-7073-9172" xsd:string
property_value: dcterms-date "2025-02-19T16:01:02Z" xsd:dateTime
[Term]
id: CL:0008060
name: GABA-Glut neuron
def: "A neuron that releases both gamma-aminobutyric acid and glutamate as vesicular neurotransmitters." [PMID:29924991, PMID:37124720, PMID:38092916]
is_a: CL:0000617 ! GABAergic neuron
is_a: CL:0000679 ! glutamatergic neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission
intersection_of: capable_of GO:0061535 ! glutamate secretion, neurotransmission
relationship: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission
relationship: capable_of GO:0061535 ! glutamate secretion, neurotransmission
relationship: dc-contributor https://orcid.org/0000-0002-7073-9172
property_value: dcterms-date "2025-06-19T10:06:06Z" xsd:dateTime
[Term]
id: CL:0008061
name: GABA-Chol neuron
def: "A neuron that releases both gamma-aminobutyric acid and acetylcholine as vesicular neurotransmitters. Examples include some types of striatal interneuron." [PMID:29651049]
is_a: CL:0000108 ! cholinergic neuron
is_a: CL:0000617 ! GABAergic neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0014055 ! acetylcholine secretion, neurotransmission
intersection_of: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission
relationship: capable_of GO:0014055 ! acetylcholine secretion, neurotransmission
relationship: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission
relationship: dc-contributor https://orcid.org/0000-0002-7073-9172
property_value: dcterms-date "2025-06-19T10:13:06Z" xsd:dateTime
[Term]
id: CL:0009000
name: sensory neuron of spinal nerve
def: "A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord." [GOC:nv, GOC:pr]
synonym: "spinal sensory neuron" EXACT []
is_a: CL:3000004 ! peripheral sensory neuron
intersection_of: CL:0000101 ! sensory neuron
intersection_of: RO:0002100 UBERON:0001780 ! has soma location spinal nerve
relationship: RO:0002100 UBERON:0001780 ! has soma location spinal nerve
[Term]
id: CL:0009001
name: compound eye retinal cell
def: "Any cell in the compound eye, a light sensing organ composed of ommatidia." []
xref: GOC:pr
xref: PMID:12021768
is_a: CL:0009004 ! retinal cell
relationship: part_of UBERON:0000018 ! compound eye
[Term]
id: CL:0009004
name: retinal cell
def: "Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [GOC:pr]
subset: cellxgene_subset
xref: PMID:10702418
is_a: CL:0002319 ! neural cell
intersection_of: CL:0002319 ! neural cell
intersection_of: part_of UBERON:0005388 ! photoreceptor array
relationship: part_of UBERON:0005388 ! photoreceptor array
[Term]
id: CL:0009005
name: salivary gland cell
def: "Any cell in a salivary gland." []
subset: cellxgene_subset
xref: GOC:pr
xref: http://en.wikipedia.org/wiki/Salivary_gland
is_a: CL:0000255 ! eukaryotic cell
relationship: part_of UBERON:0001044 ! saliva-secreting gland
[Term]
id: CL:0009006
name: enteroendocrine cell of small intestine
def: "An enteroendocrine cell that is located in the small intestine." [http://orcid.org/0000-0003-3440-1876]
subset: cellxgene_subset
subset: location_grouping
synonym: "small intestine enteroendocrine cell" EXACT []
is_a: CL:1001516 ! intestinal enteroendocrine cell
is_a: CL:1001598 ! small intestine secretory cell
intersection_of: CL:0000164 ! enteroendocrine cell
intersection_of: part_of UBERON:0002108 ! small intestine
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0002108 ! small intestine
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0009006" xsd:string {name="enteroendocrine cell of small intestine on CELLxGENE CellGuide"}
[Term]
id: CL:0009010
name: transit amplifying cell
def: "Transit-amplifying cells (TACs) are an undifferentiated population in transition between stem cells and differentiated cells." [http://orcid.org/0000-0003-4183-8865, PMID:24813615, PMID:28835754]
subset: cellxgene_subset
synonym: "TAC" RELATED []
synonym: "TACs" RELATED []
synonym: "transient amplifying cell" EXACT []
synonym: "transit amplifying progenitor cell" EXACT [PMID:30827895]
synonym: "transit-amplifying cell" EXACT []
is_a: CL:0000255 ! eukaryotic cell
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: develops_from CL:0000034 ! stem cell
[Term]
id: CL:0009011
name: transit amplifying cell of colon
def: "A rapidly proliferating population of cells that differentiate from stem cells of the intestinal crypt of the colon. Stem cells located in the crypts of Lieberkühn give rise to proliferating progenitor or transit amplifying cells that differentiate into the four major epithelial cell types. These include columnar absorptive cells or enterocytes, mucous secreting goblet cells, enteroendocrine cells and paneth cells." [http://orcid.org/0000-0003-4183-8865, PMID:20801415]
subset: cellxgene_subset
subset: human_reference_atlas
subset: location_grouping
synonym: "colon transit amplifying cell" EXACT []
synonym: "transient amplifying cell of colon" EXACT []
synonym: "transient amplifying cell of crypt of Lieberkuhn of colon" EXACT []
synonym: "transit amplifying cell of crypt of Lieberkuhn of colon" EXACT []
synonym: "transit amplifying cell of large intestine" BROAD []
synonym: "transit-amplifying cell of colon" EXACT []
is_a: CL:0002253 ! epithelial cell of large intestine
is_a: CL:4047017 ! transit amplifying cell of gut
intersection_of: CL:4047017 ! transit amplifying cell of gut
intersection_of: part_of UBERON:0013485 ! crypt of Lieberkuhn of colon
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0013485 ! crypt of Lieberkuhn of colon
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0009011" xsd:string {name="transit amplifying cell of colon on CELLxGENE CellGuide"}
[Term]
id: CL:0009012
name: transit amplifying cell of small intestine
def: "A rapidly proliferating population of cells that differentiate from stem cells of the intestinal crypt of the small intestine. Stem cells located in the crypts of Lieberkühn give rise to proliferating progenitor or transit amplifying cells that differentiate into the four major epithelial cell types. These include columnar absorptive cells or enterocytes, mucous secreting goblet cells, enteroendocrine cells and paneth cells." [http://orcid.org/0000-0003-4183-8865, PMID:20801415]
subset: cellxgene_subset
subset: location_grouping
synonym: "small intestine transit amplifying cell" EXACT []
synonym: "transient amplifying cell of crypt of Lieberkuhn of small intestine" EXACT []
synonym: "transient amplifying cell of small intestine" EXACT []
synonym: "transit amplifying cell of crypt of Lieberkuhn of small intestine" EXACT []
synonym: "transit-amplifying cell of small intestine" EXACT []
is_a: CL:0002254 ! epithelial cell of small intestine
is_a: CL:4047017 ! transit amplifying cell of gut
intersection_of: CL:4047017 ! transit amplifying cell of gut
intersection_of: part_of UBERON:0001241 ! crypt of Lieberkuhn of small intestine
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0001241 ! crypt of Lieberkuhn of small intestine
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0009012" xsd:string {name="transit amplifying cell of small intestine on CELLxGENE CellGuide"}
[Term]
id: CL:0009014
name: Peyer's patch lymphocyte
def: "A lymphocyte that is part of a Peyer's patch. These cells have a major role in driving the immune response to antigens sampled from the intestinal lumen, and in regulating the formation of follicle-associated epithelium and M cells in Peyer's patches by converting intestitial enterocytes into M cells." [https://orcid.org/0000-0003-4183-8865, PMID:23525039, PMID:9252325]
subset: location_grouping
synonym: "Peyer's patch resident lymphocyte" EXACT []
synonym: "small intestine Peyer's patch lymphocyte" NARROW []
is_a: CL:0000542 ! lymphocyte
intersection_of: CL:0000542 ! lymphocyte
intersection_of: part_of UBERON:0001211 ! Peyer's patch
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0001211 ! Peyer's patch
[Term]
id: CL:0009016
name: intestinal crypt stem cell of large intestine
def: "An intestinal stem cell that is located in the large intestine crypt of Liberkuhn. These stem cells reside at the bottom of crypts in the large intestine and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells." [https://orcid.org/0000-0003-4183-8865, PMID:20683682]
subset: cellxgene_subset
subset: human_reference_atlas
subset: location_grouping
synonym: "crypt stem cell of large intestine" BROAD []
synonym: "stem cell of large intestine crypt of Lieberkuhn" EXACT []
is_a: CL:0002250 ! intestinal crypt stem cell
is_a: CL:0002253 ! epithelial cell of large intestine
intersection_of: CL:0002250 ! intestinal crypt stem cell
intersection_of: part_of UBERON:0001984 ! crypt of Lieberkuhn of large intestine
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0001984 ! crypt of Lieberkuhn of large intestine
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0009017
name: intestinal crypt stem cell of small intestine
def: "An intestinal stem cell that is located in the small intestine crypt of Liberkuhn. These stem cells reside at the bottom of crypts in the small intestine and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells." [https://orcid.org/0000-0003-4183-8865, PMID:20683682]
subset: cellxgene_subset
subset: location_grouping
synonym: "crypt stem cell of small intestine" BROAD []
synonym: "stem cell of small intestine crypt of Lieberkuhn" EXACT []
is_a: CL:0002250 ! intestinal crypt stem cell
is_a: CL:0002254 ! epithelial cell of small intestine
intersection_of: CL:0002250 ! intestinal crypt stem cell
intersection_of: part_of UBERON:0001241 ! crypt of Lieberkuhn of small intestine
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0001241 ! crypt of Lieberkuhn of small intestine
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0009017" xsd:string {name="intestinal crypt stem cell of small intestine on CELLxGENE CellGuide"}
[Term]
id: CL:0009018
name: lymphocyte of large intestine lamina propria
def: "A lymphocyte that resides in the lamina propria of the large intestine." [https://orcid.org/0000-0003-4183-8865]
comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you.
subset: human_reference_atlas
subset: location_grouping
synonym: "lamina propria lymphocyte of large intestine" EXACT []
is_a: CL:0000542 ! lymphocyte
intersection_of: CL:0000542 ! lymphocyte
intersection_of: part_of UBERON:0011189 ! lamina propria of large intestine
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0011189 ! lamina propria of large intestine
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0009019
name: nephrogenic zone cell
def: "A kidney cortical cell that is part of the nephrogenic zone." [https://orcid.org/0000-0002-3163-0115, PMID:29449449]
subset: added_for_HCA
synonym: "cortical nephrogenic niche cell" EXACT []
synonym: "cortical nephrogenic zone cell" EXACT []
is_a: CL:0002681 ! kidney cortical cell
intersection_of: CL:0002681 ! kidney cortical cell
intersection_of: part_of UBERON:0009871 ! nephrogenic zone
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0009871 ! nephrogenic zone
[Term]
id: CL:0009020
name: tuft cell of appendix
def: "An intestinal tuft cell that is a part of a vermiform appendix." [http://orcid.org/0000-0003-3440-1876]
subset: location_grouping
synonym: "appendix tuft cell" EXACT []
synonym: "tuft cell of appendix vermiformis" EXACT []
synonym: "tuft cell of vermiform appendix" EXACT []
is_a: CL:0002203 ! tuft cell of large intestine
intersection_of: CL:0019032 ! intestinal tuft cell
intersection_of: part_of UBERON:0001154 ! vermiform appendix
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0001154 ! vermiform appendix
[Term]
id: CL:0009021
name: stromal cell of lamina propria of large intestine
def: "A stromal cell found in the lamina propria of the large intestine." [http://orcid.org/0000-0003-4183-8865]
subset: location_grouping
is_a: CL:0000499 ! stromal cell
intersection_of: CL:0000499 ! stromal cell
intersection_of: part_of UBERON:0011189 ! lamina propria of large intestine
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0011189 ! lamina propria of large intestine
[Term]
id: CL:0009022
name: stromal cell of lamina propria of small intestine
def: "A stromal cell found in the lamina propria of the small intestine." [http://orcid.org/0000-0003-4183-8865]
subset: cellxgene_subset
subset: location_grouping
is_a: CL:0000499 ! stromal cell
intersection_of: CL:0000499 ! stromal cell
intersection_of: part_of UBERON:0001238 ! lamina propria of small intestine
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0001238 ! lamina propria of small intestine
[Term]
id: CL:0009024
name: mesothelial cell of small intestine
def: "A mesothelial cell that is part of the small intestine." [http://orcid.org/0000-0003-4183-8865]
subset: location_grouping
is_a: CL:0008041 ! mesothelial cell of intestine
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0001206 ! serosa of small intestine
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0001206 ! serosa of small intestine
[Term]
id: CL:0009025
name: mesothelial cell of colon
def: "A mesothelial cell that is part of the colon." [http://orcid.org/0000-0003-3440-1876, http://orcid.org/0000-0003-4183-8865]
subset: location_grouping
synonym: "mesothelial cell of large intestine" BROAD []
is_a: CL:0008041 ! mesothelial cell of intestine
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0003335 ! serosa of colon
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0003335 ! serosa of colon
[Term]
id: CL:0009027
name: transit amplifying cell of appendix
def: "A transit amplifying cell that is part of a crypt of Lieberkuhn of large intestine." [http://orcid.org/0000-0003-3440-1876]
subset: location_grouping
synonym: "appendix transit amplifying cell" EXACT []
synonym: "transit amplifying cell of appendix vermiformis" EXACT []
synonym: "transit amplifying cell of vermiform appendix" EXACT []
is_a: CL:0002253 ! epithelial cell of large intestine
is_a: CL:4047017 ! transit amplifying cell of gut
intersection_of: CL:4047017 ! transit amplifying cell of gut
intersection_of: part_of UBERON:0013486 ! crypt of Lieberkuhn of appendix
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: develops_from CL:0009028 ! intestinal crypt stem cell of appendix
relationship: part_of UBERON:0013486 ! crypt of Lieberkuhn of appendix
[Term]
id: CL:0009028
name: intestinal crypt stem cell of appendix
def: "An intestinal crypt stem cell that is located in the vermiform appendix. These stem cells reside at the bottom of crypts in the appendix and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells." [http://orcid.org/0000-0003-3440-1876, PMID:20683682]
subset: location_grouping
synonym: "appendix intestinal crypt stem cell" EXACT []
synonym: "intestinal crypt stem cell of appendix vermiformis" EXACT []
synonym: "intestinal crypt stem cell of vermiform appendix" EXACT []
synonym: "stem cell of intestinal crypt of Lieberkuhn of appendix" EXACT []
synonym: "stem cell of intestinal crypt of Lieberkuhn of appendix vermiformis" EXACT []
is_a: CL:0009016 ! intestinal crypt stem cell of large intestine
intersection_of: CL:0002250 ! intestinal crypt stem cell
intersection_of: part_of UBERON:0013486 ! crypt of Lieberkuhn of appendix
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0013486 ! crypt of Lieberkuhn of appendix
[Term]
id: CL:0009029
name: mesothelial cell of appendix
def: "A mesothelial cell that is located in a vermiform appendix." [http://orcid.org/0000-0003-3440-1876]
subset: location_grouping
synonym: "appendix mesothelial cell" EXACT []
synonym: "mesothelial cell of appendix vermiformis" EXACT []
synonym: "mesothelial cell of vermiform appendix" EXACT []
is_a: CL:0008041 ! mesothelial cell of intestine
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0012498 ! serosa of appendix
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0012498 ! serosa of appendix
[Term]
id: CL:0009030
name: enteroendocrine cell of appendix
def: "An intestinal enteroendocrine cell that is located in a vermiform appendix." [http://orcid.org/0000-0003-3440-1876]
subset: location_grouping
synonym: "appendix enteroendocrine cell" EXACT []
synonym: "enteroendocrine cell of appendix vermiformis" EXACT []
synonym: "enteroendocrine cell of vermiform appendix" EXACT []
is_a: CL:1000405 ! epithelial cell of appendix
is_a: CL:1001516 ! intestinal enteroendocrine cell
intersection_of: CL:1001516 ! intestinal enteroendocrine cell
intersection_of: part_of UBERON:0001154 ! vermiform appendix
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0001154 ! vermiform appendix
[Term]
id: CL:0009031
name: T cell of appendix
def: "A T cell that is located in a vermiform appendix." [http://orcid.org/0000-0003-3440-1876]
comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you.
subset: location_grouping
synonym: "appendix T cell" EXACT []
synonym: "T cell of appendix vermiformis" EXACT []
synonym: "T cell of vermiform appendix" EXACT []
is_a: CL:0000084 ! T cell
intersection_of: CL:0000084 ! T cell
intersection_of: part_of UBERON:0001154 ! vermiform appendix
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0001154 ! vermiform appendix
[Term]
id: CL:0009032
name: B cell of appendix
def: "A B cell that is located in a vermiform appendix." [http://orcid.org/0000-0003-3440-1876]
comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you.
subset: location_grouping
synonym: "appendix B cell" EXACT []
synonym: "B cell of appendix vermiformis" EXACT []
synonym: "B cell of vermiform appendix" EXACT []
is_a: CL:0000236 ! B cell
intersection_of: CL:0000236 ! B cell
intersection_of: part_of UBERON:0001154 ! vermiform appendix
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0001154 ! vermiform appendix
[Term]
id: CL:0009033
name: plasma cell of appendix
def: "A plasma cell that is located in a vermiform appendix." [http://orcid.org/0000-0003-3440-1876]
comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you.
subset: location_grouping
synonym: "appendix plasma cell" EXACT []
synonym: "plasma cell of appendix vermiformis" EXACT []
synonym: "plasma cell of vermiform appendix" EXACT []
is_a: CL:0000786 ! plasma cell
intersection_of: CL:0000786 ! plasma cell
intersection_of: part_of UBERON:0001154 ! vermiform appendix
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0001154 ! vermiform appendix
[Term]
id: CL:0009034
name: dendritic cell of appendix
def: "A dendritic cell that is located in a vermiform appendix." [http://orcid.org/0000-0003-3440-1876]
comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you.
subset: location_grouping
synonym: "appendix dendritic cell" EXACT []
synonym: "dendritic cell of appendix vermiformis" EXACT []
synonym: "dendritic cell of vermiform appendix" EXACT []
is_a: CL:0000451 ! dendritic cell
intersection_of: CL:0000451 ! dendritic cell
intersection_of: part_of UBERON:0001154 ! vermiform appendix
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0001154 ! vermiform appendix
[Term]
id: CL:0009035
name: stromal cell of lamina propria of vermiform appendix
def: "A stromal cell found in the lamina propria of the vermiform appendix." [http://orcid.org/0000-0003-3440-1876]
subset: location_grouping
synonym: "stromal cell of appendix lamina propria" EXACT []
synonym: "stromal cell of lamina propria of appendix vermiformis" EXACT []
is_a: CL:0009021 ! stromal cell of lamina propria of large intestine
intersection_of: CL:0000499 ! stromal cell
intersection_of: part_of UBERON:0001154 ! vermiform appendix
intersection_of: part_of UBERON:0011189 ! lamina propria of large intestine
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0001154 ! vermiform appendix
relationship: part_of UBERON:0011189 ! lamina propria of large intestine
[Term]
id: CL:0009036
name: appendix macrophage
def: "A macrophage located in the vermiform appendix." [http://orcid.org/0000-0003-3440-1876]
comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you.
subset: location_grouping
synonym: "macrophage of appendix" EXACT []
synonym: "macrophage of appendix vermiformis" EXACT []
synonym: "macrophage of vermiform appendix" EXACT []
is_a: CL:0000235 ! macrophage
intersection_of: CL:0000235 ! macrophage
intersection_of: part_of UBERON:0001154 ! vermiform appendix
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0001154 ! vermiform appendix
[Term]
id: CL:0009037
name: lymph node mantle zone B cell
def: "A B lymphocyte that resides in the mantle zone of the lymph node germinal center. These are generally IgM and IgD positive activated B cells that form a 'corona' around the germinal center and are part of the establishment of a secondary lymphatic follicule." [http://orcid.org/0000-0003-4183-8865/, https://www.arppress.org/v/vspfiles/assets/images/Chapter1T25LymphNodes.pdf, PMID:8011279]
comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you.
subset: location_grouping
synonym: "mantle zone B cell" BROAD []
synonym: "mantle zone B cell of lymph node" EXACT []
is_a: CL:0000236 ! B cell
intersection_of: CL:0000236 ! B cell
intersection_of: part_of UBERON:0010420 ! lymph node germinal center mantle zone
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0010420 ! lymph node germinal center mantle zone
[Term]
id: CL:0009038
name: colon macrophage
def: "A macrophage that is located in the colon." [http://orcid.org/0000-0003-3440-1876]
comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you.
subset: cellxgene_subset
subset: location_grouping
synonym: "macrophage of colon" EXACT []
is_a: CL:0000235 ! macrophage
intersection_of: CL:0000235 ! macrophage
intersection_of: part_of UBERON:0001155 ! colon
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0001155 ! colon
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0009038" xsd:string {name="colon macrophage on CELLxGENE CellGuide"}
[Term]
id: CL:0009039
name: colon goblet cell
def: "A goblet cell that is located in the colon." [http://orcid.org/0000-0003-3440-1876]
subset: cellxgene_subset
subset: location_grouping
synonym: "goblet cell of colon" EXACT []
is_a: CL:0011108 ! colon epithelial cell
is_a: CL:1000320 ! large intestine goblet cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0000397 ! colonic epithelium
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0000397 ! colonic epithelium
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0009039" xsd:string {name="colon goblet cell on CELLxGENE CellGuide"}
[Term]
id: CL:0009040
name: stromal cell of lamina propria of colon
def: "A stromal cell found in the lamina propria of the colon." [http://orcid.org/0000-0003-3440-1876]
subset: location_grouping
synonym: "stromal cell of colon lamina propria" EXACT []
is_a: CL:0009021 ! stromal cell of lamina propria of large intestine
intersection_of: CL:0000499 ! stromal cell
intersection_of: part_of UBERON:0007177 ! lamina propria of mucosa of colon
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0007177 ! lamina propria of mucosa of colon
[Term]
id: CL:0009041
name: tuft cell of colon
def: "A tuft cell that is part of the colonic epithelium, primarily adapted for microbial sensing in the dense colonic microbiota. Unlike its small intestinal counterpart, it does not participate in parasite-driven tuft cell–ILC2 circuits. Instead, it detects bacterial metabolites via taste-signaling pathways (Strine and Craig, 2022). The colonic tuft cell plays a key role in epithelial repair, modulates inflammatory responses through IL-25 secretion, and contributes to intestinal homeostasis by balancing microbiome interactions (Sebastian et al., 2021)." [http://orcid.org/0000-0003-3440-1876, PMID:33079783, PMID:35271673]
subset: cellxgene_subset
subset: location_grouping
synonym: "colon tuft cell" EXACT []
is_a: CL:0002203 ! tuft cell of large intestine
is_a: CL:0011108 ! colon epithelial cell
intersection_of: CL:0002204 ! tuft cell
intersection_of: part_of UBERON:0000397 ! colonic epithelium
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0000397 ! colonic epithelium
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0009041" xsd:string {name="tuft cell of colon on CELLxGENE CellGuide"}
[Term]
id: CL:0009042
name: enteroendocrine cell of colon
def: "An enteroendocrine cell that is located in the colon." [http://orcid.org/0000-0003-3440-1876]
subset: cellxgene_subset
subset: location_grouping
synonym: "colon enteroendocrine cell" EXACT []
is_a: CL:0011108 ! colon epithelial cell
is_a: CL:1001516 ! intestinal enteroendocrine cell
intersection_of: CL:0000164 ! enteroendocrine cell
intersection_of: part_of UBERON:0001155 ! colon
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0001155 ! colon
[Term]
id: CL:0009043
name: intestinal crypt stem cell of colon
def: "An intestinal crypt stem cell that is located in the crypt of Lieberkuhn of colon." [http://orcid.org/0000-0003-3440-1876, PMID:10841502]
subset: cellxgene_subset
subset: location_grouping
is_a: CL:0009016 ! intestinal crypt stem cell of large intestine
intersection_of: CL:0002250 ! intestinal crypt stem cell
intersection_of: part_of UBERON:0013485 ! crypt of Lieberkuhn of colon
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0013485 ! crypt of Lieberkuhn of colon
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0009043" xsd:string {name="intestinal crypt stem cell of colon on CELLxGENE CellGuide"}
[Term]
id: CL:0009044
name: lymphocyte of small intestine lamina propria
def: "A lymphocyte that resides in the lamina propria of the small intestine. Lamina propria leukocytes and intraepithelial lymphocytes are the effector compartments of the gut mucosal immune system. Lymphocytes circulate through gut associated lymphoid tissues until recruitment by intestinal antigens. They are involved in the gut immune response." [https://orcid.org/0000-0003-4183-8865, PMID:26551552]
comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you.
subset: location_grouping
synonym: "gastrointestinal tract (lamina propria) lymphocyte of small intestine" EXACT []
synonym: "gastrointestinal tract small intestine (lamina propria) leukocyte" BROAD []
synonym: "lamina propria lymphocyte of small intestine" EXACT []
synonym: "small intestine lamina propria leukocyte" BROAD []
synonym: "small intestine lamina propria leukocyte (LPL)" BROAD []
synonym: "small intestine lamina propria lymphocyte" EXACT []
is_a: CL:0000542 ! lymphocyte
intersection_of: CL:0000542 ! lymphocyte
intersection_of: part_of UBERON:0001238 ! lamina propria of small intestine
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0001238 ! lamina propria of small intestine
[Term]
id: CL:0009045
name: B cell of medullary sinus of lymph node
def: "A B cell found in the lymph node medullary sinus." [http://orcid.org/0000-0003-4183-8865]
comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you.
subset: location_grouping
is_a: CL:0000236 ! B cell
intersection_of: CL:0000236 ! B cell
intersection_of: part_of UBERON:0009744 ! lymph node medullary sinus
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0009744 ! lymph node medullary sinus
[Term]
id: CL:0009046
name: T cell of medullary sinus of lymph node
def: "A T cell found in the lymph node medullary sinus." [http://orcid.org/0000-0003-4183-8865]
comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you.
subset: location_grouping
is_a: CL:0000084 ! T cell
intersection_of: CL:0000084 ! T cell
intersection_of: part_of UBERON:0009744 ! lymph node medullary sinus
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0009744 ! lymph node medullary sinus
[Term]
id: CL:0009047
name: macrophage of medullary sinus of lymph node
def: "A macrophage found in the medullary sinus of the lymph node." [http://orcid.org/0000-0003-4183-8865]
comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you.
subset: location_grouping
synonym: "lymph node medullary sinus macrophage" EXACT []
synonym: "medullary sinus macrophage" BROAD []
is_a: CL:0000235 ! macrophage
intersection_of: CL:0000235 ! macrophage
intersection_of: part_of UBERON:0009744 ! lymph node medullary sinus
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0009744 ! lymph node medullary sinus
[Term]
id: CL:0009048
name: anorectum macrophage
def: "A macrophage that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876]
comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you.
subset: location_grouping
synonym: "macrophage of anorectum" EXACT []
is_a: CL:0000235 ! macrophage
intersection_of: CL:0000235 ! macrophage
intersection_of: part_of UBERON:8410050 ! anorectum
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:8410050 ! anorectum
[Term]
id: CL:0009049
name: smooth muscle cell of high endothelial venule of lymph node
def: "A layer of smooth muscle cells that forms the outer layer of the high endothelial venule of lymph node and pumps to allow flow of lymph fluid carrying lymphocytes." [http://orcid.org/0000-0003-4183-8865, PMID:27881983]
subset: location_grouping
synonym: "high endothelial venule of lymph node smooth muscle cell" EXACT []
synonym: "high endothelial venule smooth muscle cell" BROAD []
is_a: CL:0008035 ! microcirculation associated smooth muscle cell
is_a: CL:0019018 ! blood vessel smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:8410038 ! high endothelial venule of lymph node
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:8410038 ! high endothelial venule of lymph node
[Term]
id: CL:0009050
name: B cell of anorectum
def: "A B cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876]
comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you.
subset: location_grouping
is_a: CL:0000236 ! B cell
intersection_of: CL:0000236 ! B cell
intersection_of: part_of UBERON:8410050 ! anorectum
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:8410050 ! anorectum
[Term]
id: CL:0009051
name: T cell of anorectum
def: "A T cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876]
comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you.
subset: location_grouping
is_a: CL:0000084 ! T cell
intersection_of: CL:0000084 ! T cell
intersection_of: part_of UBERON:8410050 ! anorectum
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:8410050 ! anorectum
[Term]
id: CL:0009052
name: smooth muscle cell of anorectum
def: "A smooth muscle cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876]
subset: location_grouping
synonym: "anorectum smooth muscle cell" EXACT []
is_a: CL:1000279 ! smooth muscle cell of large intestine
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:8410050 ! anorectum
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:8410050 ! anorectum
[Term]
id: CL:0009053
name: stromal cell of anorectum lamina propria
def: "A stromal cell found in the lamina propria of the anorectum." [http://orcid.org/0000-0003-3440-1876]
subset: location_grouping
is_a: CL:0009021 ! stromal cell of lamina propria of large intestine
intersection_of: CL:0000499 ! stromal cell
intersection_of: part_of UBERON:0011189 ! lamina propria of large intestine
intersection_of: part_of UBERON:8410050 ! anorectum
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0011189 ! lamina propria of large intestine
relationship: part_of UBERON:8410050 ! anorectum
[Term]
id: CL:0009056
name: transit amplifying cell of anorectum
def: "A transit amplifying cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876]
subset: location_grouping
synonym: "anorectum transit amplifying cell" EXACT []
is_a: CL:0002253 ! epithelial cell of large intestine
is_a: CL:4047017 ! transit amplifying cell of gut
intersection_of: CL:4047017 ! transit amplifying cell of gut
intersection_of: part_of UBERON:8410050 ! anorectum
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:8410050 ! anorectum
[Term]
id: CL:0009057
name: anorectum goblet cell
def: "A goblet cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876]
subset: location_grouping
synonym: "goblet cell of anorectum" EXACT []
is_a: CL:1000320 ! large intestine goblet cell
intersection_of: CL:1000320 ! large intestine goblet cell
intersection_of: part_of UBERON:8410050 ! anorectum
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:8410050 ! anorectum
[Term]
id: CL:0009059
name: plasma cell of medullary sinus of lymph node
def: "A plasma cell that is located in the medullary sinus of the lymph node." [http://orcid.org/0000-0003-4183-8865]
comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you.
subset: location_grouping
synonym: "medullary plasma cell" BROAD []
synonym: "medullary sinus plasma cell" BROAD []
synonym: "plasma cell of medullary sinus" BROAD []
is_a: CL:0000786 ! plasma cell
intersection_of: CL:0000786 ! plasma cell
intersection_of: part_of UBERON:0009744 ! lymph node medullary sinus
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0009744 ! lymph node medullary sinus
[Term]
id: CL:0009060
name: marginal zone B cell of lymph node
def: "A mature B cell located in the marginal zone of the lymph node." [http://orcid.org/0000-0003-4183-8865, WikipediaVersioned:Marginal_zone_B-cell&oldid=1032071222]
subset: location_grouping
synonym: "lymph node marginal zone B cell" EXACT []
synonym: "marginal zone B cell" BROAD []
is_a: CL:0000785 ! mature B cell
intersection_of: CL:0000785 ! mature B cell
intersection_of: part_of UBERON:8410065 ! lymph node follicle marginal zone
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:8410065 ! lymph node follicle marginal zone
[Term]
id: CL:0009061
name: intestinal crypt stem cell of anorectum
def: "An intestinal crypt stem cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876]
subset: location_grouping
synonym: "anorectum intestinal crypt stem cell" EXACT []
is_a: CL:0009016 ! intestinal crypt stem cell of large intestine
intersection_of: CL:0009016 ! intestinal crypt stem cell of large intestine
intersection_of: part_of UBERON:8410050 ! anorectum
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:8410050 ! anorectum
[Term]
id: CL:0009063
name: enteroendocrine cell of anorectum
def: "An enteroendocrine cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876]
subset: location_grouping
synonym: "anorectum enteroendocrine cell" EXACT []
is_a: CL:0002253 ! epithelial cell of large intestine
is_a: CL:1001516 ! intestinal enteroendocrine cell
intersection_of: CL:0000164 ! enteroendocrine cell
intersection_of: part_of UBERON:8410050 ! anorectum
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:8410050 ! anorectum
[Term]
id: CL:0009064
name: lymph node paracortex T cell
def: "A T cell located in the lymph node paracortex, where macrophages and dendritic cells present antigenic peptides to these naïve T cells, stimulating them to become activated helper T cells or cytotoxic T lymphocytes." [http://orcid.org/0000-0003-4183-8865]
subset: location_grouping
synonym: "paracortex T cell" BROAD []
synonym: "paracortical T cell" BROAD []
synonym: "T cell of lymph node paracortex" EXACT []
is_a: CL:0000084 ! T cell
intersection_of: CL:0000084 ! T cell
intersection_of: part_of UBERON:8410066 ! lymph node paracortex
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:8410066 ! lymph node paracortex
[Term]
id: CL:0009065
name: tuft cell of anorectum
def: "An intestinal tuft cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876]
subset: location_grouping
synonym: "anorectum tuft cell" EXACT []
is_a: CL:0002203 ! tuft cell of large intestine
intersection_of: CL:0019032 ! intestinal tuft cell
intersection_of: part_of UBERON:8410050 ! anorectum
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:8410050 ! anorectum
[Term]
id: CL:0009066
name: stratified squamous epithelial cell of anal canal
def: "A stratified squamous epithelial cell that is part of the anal canal." [http://orcid.org/0000-0003-3440-1876]
comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you.
subset: location_grouping
synonym: "anal canal stratified squamous epithelial cell" EXACT []
is_a: CL:0000240 ! stratified squamous epithelial cell
is_a: CL:0002253 ! epithelial cell of large intestine
intersection_of: CL:0000240 ! stratified squamous epithelial cell
intersection_of: part_of UBERON:0015716 ! anal canal epithelium
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0015716 ! anal canal epithelium
[Term]
id: CL:0009080
name: tuft cell of small intestine
def: "A tuft cell located in the small intestine." [http://orcid.org/0000-0003-3440-1876, http://orcid.org/0000-0003-4183-8865]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "brush cell of epithelium of small intestine" EXACT []
synonym: "brush cell of epithelium proper of small intestine" EXACT []
synonym: "brush cell of small intestine" EXACT []
synonym: "tuft cell of epithelium of small intestine" EXACT []
is_a: CL:0002254 ! epithelial cell of small intestine
is_a: CL:0019032 ! intestinal tuft cell
intersection_of: CL:0019032 ! intestinal tuft cell
intersection_of: part_of UBERON:0002108 ! small intestine
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: depiction http://purl.obolibrary.org/obo/cl/images/Small-intestine-cells.png {terms:license="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.1186/s13619-020-00061-5", comment="Figure depicts a cross section of intestinal villi in the small intestine, including the crypts of Lieberkuhn (seen here as ‘crypt’), as well as the layer specific locations of cells that exist within the gastrointestinal tract. Layers depicted here include epithelium (rows of cells bordering villus), submucosa (white space below the epithelium containing networks of neurons and ganglia depicted in pink), muscularis mucosae (blue layer), muscularis propria (referred to here as muscle layer).\n\nISC: Intestinal Stem Cell \nTA: Transit Amplifying Cells"}
relationship: part_of UBERON:0001902 ! epithelium of small intestine
relationship: part_of UBERON:0002108 ! small intestine
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0009084
name: glandular epithelial cell of endometrium
def: "An epithelial cell that is part of an endometrium glandular epithelium." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865]
subset: human_reference_atlas
subset: location_grouping
synonym: "endometrial glandular epithelial cell" EXACT []
synonym: "epithelial cell of endometrial gland" EXACT []
xref: EFO:0010710
is_a: CL:0002149 ! epithelial cell of uterus
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0012276 ! endometrium glandular epithelium
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0012276 ! endometrium glandular epithelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2021-11-30T16:13:30Z" xsd:dateTime
[Term]
id: CL:0009086
name: endothelial cell of respiratory system lymphatic vessel
def: "An endothelial cell that is part of a respiratory system lymphatic vessel." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865]
subset: cellxgene_subset
subset: human_reference_atlas
subset: location_grouping
xref: EFO:0010667
is_a: CL:0002138 ! endothelial cell of lymphatic vessel
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0003456 ! respiratory system lymphatic vessel
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0003456 ! respiratory system lymphatic vessel
relationship: part_of UBERON:0003529 ! respiratory system lymphatic vessel endothelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2021-12-03T14:00:44Z" xsd:dateTime
[Term]
id: CL:0009089
name: lung pericyte
def: "A pericyte cell that is part of a lung." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865]
comment: The marker set HIGD1B, KCNK3 can identify the Human cell type lung pericyte in the lung with a confidence of 0.84 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"}
subset: cellxgene_subset
subset: human_reference_atlas
subset: location_grouping
synonym: "lung pericyte cell" EXACT []
synonym: "pulmonary pericyte" EXACT []
xref: EFO:0010669
is_a: CL:0000669 ! pericyte
intersection_of: CL:0000669 ! pericyte
intersection_of: part_of UBERON:0002048 ! lung
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0002048 ! lung
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0015004 CLM:1000047 ! has characterizing marker set
property_value: dcterms-date "2021-12-03T17:13:33Z" xsd:dateTime
[Term]
id: CL:0009091
name: Leydig stem cell
def: "A stem cell found in the interstitial compartment of the neonatal testis; it is capable of self-renewal as well as differentiation into steroidogenic cells (adult Leydig cells). Intermediate stages of development include progenitor Leydig cells and immature Leydig cells." [http://orcid.org/0000-0002-0819-0473, PMID:21181888]
synonym: "stem Leydig cell" EXACT []
is_a: CL:0000034 ! stem cell
is_a: CL:4030031 ! interstitial cell
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0005212 ! Leydig cell region of testis
property_value: dcterms-date "2022-02-18T14:09:25Z" xsd:dateTime
[Term]
id: CL:0009092
name: endothelial cell of placenta
def: "An endothelial cell that is part of a placenta." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865]
subset: cellxgene_subset
subset: location_grouping
synonym: "placental endothelial cell" EXACT []
xref: EFO:0010708
is_a: CL:0000115 ! endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0001987 ! placenta
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0001987 ! placenta
property_value: dcterms-date "2021-12-13T13:53:01Z" xsd:dateTime
[Term]
id: CL:0009093
name: smooth muscle cell of placenta
def: "A smooth muscle cell that is part of a placenta." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865]
subset: location_grouping
synonym: "placental smooth muscle cell" EXACT []
xref: EFO:0010709
is_a: CL:0000192 ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0001987 ! placenta
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0001987 ! placenta
property_value: dcterms-date "2021-12-13T13:56:42Z" xsd:dateTime
[Term]
id: CL:0009094
name: endothelial cell of hepatic portal vein
def: "An endothelial cell that is part of a hepatic portal vein." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865, PMID:30348985]
subset: location_grouping
synonym: "portal endothelial cell" BROAD []
xref: EFO:0010704
is_a: CL:0002543 ! vein endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0001639 ! hepatic portal vein
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0001639 ! hepatic portal vein
property_value: dcterms-date "2021-12-13T14:01:05Z" xsd:dateTime
[Term]
id: CL:0009095
name: endothelial cell of uterus
def: "An endothelial cell that is part of a uterus." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865]
subset: cellxgene_subset
subset: location_grouping
synonym: "uterine endothelial cell" EXACT []
xref: EFO:0010711
is_a: CL:0000115 ! endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0000995 ! uterus
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0000995 ! uterus
property_value: dcterms-date "2021-12-13T14:39:25Z" xsd:dateTime
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0009095" xsd:string {name="endothelial cell of uterus on CELLxGENE CellGuide"}
[Term]
id: CL:0009097
name: embryonic skeletal muscle fiber
def: "A skeletal muscle fiber found in an embryo. In mammalian embryos, skeletal muscle expresses myosin heavy chain-embryonic (MyHC-emb, encoded by the MYH3 gene), which regulates skeletal muscle development." [http://orcid.org/0000-0003-2034-601X, PMID:32094117, PMID:7196501]
is_a: CL:0008002 ! skeletal muscle fiber
intersection_of: CL:0008002 ! skeletal muscle fiber
intersection_of: existence_starts_and_ends_during UBERON:0000068 ! embryo stage
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: existence_starts_and_ends_during UBERON:0000068 ! embryo stage
property_value: dcterms-date "2022-02-21T15:39:10Z" xsd:dateTime
[Term]
id: CL:0009098
name: fetal and neonatal skeletal muscle fiber
def: "A skeletal muscle fiber found at the fetal and neonatal stages. In mammalian fetuses and neonates, skeletal muscle expresses myosin heavy chain-neonatal (MyHC-neo, encoded by the MYH8 gene). This expression disappears shortly after birth and is replaced by expression of adult heavy chain myosins." [http://orcid.org/0000-0003-2034-601X, PMID:26180627, PMID:7196501]
is_a: CL:0008002 ! skeletal muscle fiber
intersection_of: CL:0008002 ! skeletal muscle fiber
intersection_of: existence_ends_during UBERON:0007221 ! neonate stage
intersection_of: existence_starts_during UBERON:0000092 ! post-embryonic stage
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: existence_ends_during UBERON:0007221 ! neonate stage
relationship: existence_starts_during UBERON:0000092 ! post-embryonic stage
property_value: dcterms-date "2022-02-21T15:43:16Z" xsd:dateTime
[Term]
id: CL:0009100
name: hepatic portal fibroblast
def: "A fibroblast located in the portal triad. Hepatic portal fibroblast are a non-parenchymal cell population located adjacent to bile duct epithelia in liver and are distinct from stellate cells. They differentiate into fibrogenic myofibroblasts during chronic injury states producing high levels of collagen." [https://orcid.org/0000-0001-7655-4833, PMID:20209607, PMID:24814904]
subset: human_reference_atlas
synonym: "portal fibroblast" BROAD []
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001279 ! portal triad
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0001279 ! portal triad
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2022-03-17T12:00:44Z" xsd:dateTime
[Term]
id: CL:0009115
name: lymph node lymphatic vessel endothelial cell
def: "An endothelial cell located in a lymph node lymphatic vessel." [https://orcid.org/0000-0001-7655-4833]
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:0002138 ! endothelial cell of lymphatic vessel
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0000029 ! lymph node
intersection_of: part_of UBERON:0001473 ! lymphatic vessel
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0000029 ! lymph node
relationship: part_of UBERON:0001473 ! lymphatic vessel
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/1472" xsd:string
[Term]
id: CL:0009116
name: progenitor cell of mammary luminal epithelium
def: "A progenitor cell with the potential to differentiate into luminal epithelial cells of mammary glands. In mouse, CD61 and c-kit were found to be coexpressed by the majority of, but not all, committed luminal progenitor cells." [https://orcid.org/0000-0003-4412-7970, PMID:19063729, PMID:20346151, PMID:21930782]
subset: cellxgene_subset
synonym: "luminal progenitor cell" BROAD []
synonym: "progenitor cell of luminal mammary epithelium" EXACT []
is_a: CL:0011026 ! progenitor cell
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0001911 ! mammary gland
[Term]
id: CL:0010001
name: stromal cell of bone marrow
def: "A stromal cell that is part_of a bone marrow." []
subset: cellxgene_subset
synonym: "bone marrow stromal cell" EXACT []
is_a: CL:0000499 ! stromal cell
is_a: CL:0002092 ! bone marrow cell
intersection_of: CL:0000499 ! stromal cell
intersection_of: part_of UBERON:0002371 ! bone marrow
relationship: dc-contributor https://orcid.org/0000-0002-6601-2165
relationship: part_of UBERON:0002371 ! bone marrow
[Term]
id: CL:0010002
name: epithelial cell of umbilical artery
def: "An epithelial cell that is part_of a umbilical artery." []
synonym: "umbilical artery epithelial cell" EXACT []
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001310 ! umbilical artery
relationship: dc-contributor https://orcid.org/0000-0002-6601-2165
relationship: part_of UBERON:0001310 ! umbilical artery
[Term]
id: CL:0010004
name: mononuclear cell of bone marrow
def: "A mononuclear cell that is part_of a bone marrow." []
synonym: "bone marrow mononuclear cell" EXACT []
is_a: CL:0000842 ! mononuclear leukocyte
is_a: CL:1001610 ! bone marrow hematopoietic cell
intersection_of: CL:0000842 ! mononuclear leukocyte
intersection_of: part_of UBERON:0002371 ! bone marrow
relationship: dc-contributor https://orcid.org/0000-0002-6601-2165
relationship: part_of UBERON:0002371 ! bone marrow
[Term]
id: CL:0010005
name: atrioventricular bundle cell
def: "A specialized cardiomyocyte that transmit signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart]
synonym: "AV bundle cell" EXACT []
is_a: CL:0010007 ! His-Purkinje system cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0002353 ! bundle of His
relationship: part_of UBERON:0002353 ! bundle of His
[Term]
id: CL:0010006
name: cardiac blood vessel endothelial cell
def: "Any blood vessel endothelial cell that is part of some heart." [FBC:Autogenerated]
subset: cellxgene_subset
is_a: CL:0000071 ! blood vessel endothelial cell
is_a: CL:0010008 ! cardiac endothelial cell
intersection_of: CL:0000071 ! blood vessel endothelial cell
intersection_of: part_of UBERON:0000948 ! heart
relationship: part_of UBERON:0000948 ! heart
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0010006" xsd:string {name="cardiac blood vessel endothelial cell on CELLxGENE CellGuide"}
[Term]
id: CL:0010007
name: His-Purkinje system cell
def: "Any cell that is part of some His-Purkinje system." [FBC:Autogenerated]
is_a: CL:0002494 ! cardiocyte
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0004146 ! His-Purkinje system
relationship: part_of UBERON:0004146 ! His-Purkinje system
[Term]
id: CL:0010008
name: cardiac endothelial cell
def: "Any endothelial cell that is part of some heart." [FBC:Autogenerated]
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:0000115 ! endothelial cell
is_a: CL:0002494 ! cardiocyte
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0000948 ! heart
relationship: part_of UBERON:0000948 ! heart
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0010008" xsd:string {name="cardiac endothelial cell on CELLxGENE CellGuide"}
[Term]
id: CL:0010009
name: camera-type eye photoreceptor cell
def: "Any photoreceptor cell that is part of some camera-type eye." [FBC:Autogenerated]
synonym: "camera type eye photoreceptor cell" EXACT []
is_a: CL:0000287 ! eye photoreceptor cell
is_a: CL:0009004 ! retinal cell
intersection_of: CL:0000210 ! photoreceptor cell
intersection_of: part_of UBERON:0000019 ! camera-type eye
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: part_of UBERON:0000019 ! camera-type eye
relationship: part_of UBERON:0000966 {seeAlso="https://github.com/obophenotype/cell-ontology/issues/2245"} ! retina
[Term]
id: CL:0010010
name: cerebellar stellate cell
def: "A GABAergic interneuron that is located in the molecular layer of the cerebellum. This cell receives excitatory inputs primarily from parallel fibers and plays a crucial role in feed-forward inhibition by suppressing the activity of Purkinje cells and modulating the output of the cerebellar cortex. The stellate cell is part of the local circuitry that contributes to the fine-tuning of motor coordination and a regulator of cerebellar blood flow via neurovascular coupling." [PMID:31110133, PMID:5042759]
synonym: "cerebellar SC" RELATED OMO:0003000 [PMID:31110133]
is_a: CL:0000691 ! stellate interneuron
is_a: CL:4042035 ! molecular layer interneuron
intersection_of: CL:0000122 ! stellate neuron
intersection_of: RO:0002100 UBERON:0002974 ! has soma location molecular layer of cerebellar cortex
relationship: RO:0002100 UBERON:0002974 ! has soma location molecular layer of cerebellar cortex
[Term]
id: CL:0010011
name: cerebral cortex GABAergic interneuron
def: "A GABAergic interneuron whose soma is located in the cerebral cortex." [GOC:dos]
subset: cellxgene_subset
is_a: CL:0008031 ! cortical interneuron
is_a: CL:0011005 ! GABAergic interneuron
intersection_of: CL:0011005 ! GABAergic interneuron
intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
relationship: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0010011" xsd:string {name="cerebral cortex GABAergic interneuron on CELLxGENE CellGuide"}
[Term]
id: CL:0010012
name: cerebral cortex neuron
def: "A CNS neuron of the cerebral cortex." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "cortical neuron" EXACT []
synonym: "neuron of cerebral cortex" EXACT []
xref: BTO:0004102
xref: FMA:84104
is_a: CL:0012001 ! neuron of the forebrain
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0010012" xsd:string {name="cerebral cortex neuron on CELLxGENE CellGuide"}
property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/1359" xsd:string
[Term]
id: CL:0010015
name: coronet cell
def: "A highly specialized cell type exclusive to and forming neuroepithelium of the Saccus vasculosus, covering the caudal diverticulum of the infundibular recess." [GOC:mr, PMID:17595538]
comment: Editor note: remember to link to Saccus vasculosus in next uberon release
is_a: CL:0000066 ! epithelial cell
[Term]
id: CL:0010017
name: zygote
def: "A zygote in a plant or an animal." []
xref: MESH:D015053
is_a: CL:0000000 ! cell
relationship: seeAlso https://github.com/obophenotype/cell-ontology/issues/786
[Term]
id: CL:0010020
name: cardiac glial cell
def: "Any glial cell that is part of some heart." [FBC:Autogenerated]
is_a: CL:0000125 ! glial cell
is_a: CL:0002494 ! cardiocyte
intersection_of: CL:0000125 ! glial cell
intersection_of: part_of UBERON:0000948 ! heart
relationship: part_of UBERON:0000948 ! heart
[Term]
id: CL:0010021
name: cardiac myoblast
def: "Any myoblast that develops into some cardiac muscle cell." [FBC:Autogenerated]
xref: MESH:D032386
is_a: CL:0000056 ! myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: develops_into CL:0000746 ! cardiac muscle cell
relationship: develops_into CL:0000746 ! cardiac muscle cell
[Term]
id: CL:0010022
name: cardiac neuron
def: "A neuron that has its soma in the heart." [PMID:12486170, PMID:29265764]
comment: This term is used in 3 GO terms that were created as part of the heart development focus project.
subset: cellxgene_subset
is_a: CL:2000032 ! peripheral nervous system neuron
intersection_of: CL:2000032 ! peripheral nervous system neuron
intersection_of: RO:0002100 UBERON:0000948 ! has soma location heart
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: RO:0002100 UBERON:0000948 ! has soma location heart
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0010022" xsd:string {name="cardiac neuron on CELLxGENE CellGuide"}
property_value: seeAlso "https://github.com/obophenotype/cell-ontology/pull/1488" xsd:string
[Term]
id: CL:0011000
name: dorsal horn interneuron
def: "A CNS interneuron located in the dorsal horn of the spinal cord." [GOC:nv]
synonym: "dorsal spinal cord interneuron" RELATED []
is_a: CL:0002611 ! neuron of the dorsal spinal cord
is_a: CL:0005000 {is_inferred="true"} ! spinal cord interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0002100 UBERON:0002256 ! has soma location dorsal horn of spinal cord
relationship: RO:0002100 UBERON:0002256 ! has soma location dorsal horn of spinal cord
[Term]
id: CL:0011001
name: spinal cord motor neuron
def: "A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement." [GOC:nv]
subset: cellxgene_subset
is_a: CL:0000100 {is_inferred="true"} ! motor neuron
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000100 ! motor neuron
intersection_of: RO:0002100 UBERON:0002240 ! has soma location spinal cord
relationship: RO:0002100 UBERON:0002240 ! has soma location spinal cord
[Term]
id: CL:0011003
name: magnocellular neurosecretory cell
def: "A neurosecretory neuron residing mainly in the hypothalamic supraoptic and paraventricular nuclei and in a number of smaller accessory cell groups between these two nuclei, that is capable of secreting the hormones oxytocin or vasopressin, and sometimes both, into the systemic circulation." [GOC:nv, MP:0009467, PMID:10711808]
synonym: "magnocellular neuron" EXACT []
xref: ILX:0107463
is_a: CL:0000165 ! neuroendocrine cell
is_a: CL:0012001 ! neuron of the forebrain
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: RO:0002100 UBERON:0001898 ! has soma location hypothalamus
[Term]
id: CL:0011004
name: lens fiber cell
def: "A vetebrate lens cell that is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [GO:0070307, GOC:nv]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "lens fibre cell" EXACT []
xref: ZFA:0009401 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0002222 ! vertebrate lens cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0011004" xsd:string {name="lens fiber cell on CELLxGENE CellGuide"}
[Term]
id: CL:0011005
name: GABAergic interneuron
def: "An interneuron that uses GABA as a vesicular neurotransmitter. These interneurons are inhibitory" [GOC:CellBLAST, GOC:nv, PMID:29724907]
comment: The formal and textual definitions of this term will need to be altered if evidence for non-inhibitory GABA-ergic neurons emerges.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "GABAergic inhibitory interneuron" EXACT []
is_a: CL:0000498 ! inhibitory interneuron
is_a: CL:0000617 ! GABAergic neuron
intersection_of: CL:0000099 ! interneuron
intersection_of: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission
relationship: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0011005" xsd:string {name="GABAergic interneuron on CELLxGENE CellGuide"}
[Term]
id: CL:0011007
name: paraxial cell
def: "A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites." [GOC:NV, PMID:11687492]
subset: cellxgene_subset
synonym: "paraxial mesoderm cell" EXACT []
synonym: "presomitic mesoderm cell" NARROW []
synonym: "somitic mesoderm cell" EXACT []
is_a: CL:0000222 ! mesodermal cell
intersection_of: CL:0000222 ! mesodermal cell
intersection_of: part_of UBERON:0003059 ! presomitic mesoderm
relationship: part_of UBERON:0003059 ! presomitic mesoderm
[Term]
id: CL:0011012
name: neural crest cell
def: "A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells." [https://orcid.org/0000-0001-5208-3432, https://orcid.org/0000-0002-9900-7880]
subset: cellxgene_subset
is_a: CL:0000048 ! multi fate stem cell
is_a: CL:0002321 ! embryonic cell (metazoa)
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0011012" xsd:string {name="neural crest cell on CELLxGENE CellGuide"}
[Term]
id: CL:0011013
name: motile sperm cell
def: "A sperm cell that is cabaple of motion (motility)." [PMID:30612620]
is_a: CL:0000019 ! sperm
is_a: CL:0000219 ! motile cell
intersection_of: CL:0000019 ! sperm
intersection_of: capable_of GO:0097722 ! sperm motility
relationship: capable_of GO:0097722 ! sperm motility
relationship: dc-contributor https://orcid.org/0000-0001-5208-3432
[Term]
id: CL:0011016
name: flagellated sperm cell
def: "A motile sperm cell that contains a slender threadlike microscopic appendage that enables motion." [https://www.lexico.com/en/definition/flagellum, PMID:30612620]
is_a: CL:0011013 ! motile sperm cell
intersection_of: CL:0011013 ! motile sperm cell
intersection_of: capable_of GO:0030317 ! flagellated sperm motility
relationship: capable_of GO:0030317 ! flagellated sperm motility
relationship: dc-contributor https://orcid.org/0000-0001-5208-3432
[Term]
id: CL:0011019
name: mesothelial cell of epicardium
def: "A mesothelial cell that is part of the epicardium." []
subset: cellxgene_subset
is_a: CL:0000077 ! mesothelial cell
is_a: CL:0002494 ! cardiocyte
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0002348 ! epicardium
relationship: dc-contributor https://orcid.org/0000-0001-5208-3432
relationship: part_of UBERON:0002348 ! epicardium
[Term]
id: CL:0011021
name: fibroblast of upper back skin
def: "A fibroblast that is part of upper back skin." []
is_a: CL:0011022 ! fibroblast of skin of back
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0009015 ! upper back skin
relationship: dc-contributor https://orcid.org/0000-0001-5208-3432
relationship: part_of UBERON:0009015 ! upper back skin
[Term]
id: CL:0011022
name: fibroblast of skin of back
def: "A fibroblast that is part of skin of back." []
is_a: CL:0002620 ! skin fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001068 ! skin of back
relationship: dc-contributor https://orcid.org/0000-0001-5208-3432
relationship: part_of UBERON:0001068 ! skin of back
[Term]
id: CL:0011026
name: progenitor cell
def: "A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses." [https://doi.org/10.1016/B978-0-12-409503-8.00002-0, ISBN:978-1-62808-994-3]
subset: cellxgene_subset
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0011115 ! precursor cell
intersection_of: CL:0011115 ! precursor cell
intersection_of: develops_from CL:0000034 ! stem cell
relationship: dc-contributor https://orcid.org/0000-0001-5208-3432
relationship: develops_from CL:0000034 ! stem cell
[Term]
id: CL:0011027
name: skeletal muscle fibroblast
def: "Any fibroblast that is part of skeletal muscle tissue." [https://orcid.org/0000-0001-6164-0667, PMID:28369879]
subset: cellxgene_subset
synonym: "skeleton muscle fibroblast" EXACT []
is_a: CL:0000188 ! cell of skeletal muscle
is_a: CL:1001609 ! muscle fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue
relationship: dc-contributor https://orcid.org/0000-0001-5208-3432
relationship: part_of UBERON:0001134 ! skeletal muscle tissue
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0011027" xsd:string {name="skeletal muscle fibroblast on CELLxGENE CellGuide"}
[Term]
id: CL:0011030
name: dermal microvascular endothelial cell
def: "Any microvascular endothelial cell that is part of the dermis." [BTO:0004574, CL:patterns/cellPartOfAnatomicalEntity]
synonym: "dermal microvascular endothelium cell" EXACT []
synonym: "DMEC cell" EXACT []
is_a: CL:2000008 ! microvascular endothelial cell
is_a: CL:2000010 ! dermis blood vessel endothelial cell
intersection_of: CL:2000008 ! microvascular endothelial cell
intersection_of: part_of UBERON:0002067 ! dermis
relationship: dc-contributor https://orcid.org/0000-0001-5208-3432
relationship: part_of UBERON:0002067 ! dermis
[Term]
id: CL:0011101
name: chorionic trophoblast cell
def: "Cells of the uterine chorion that acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer." [GOC:NV]
subset: cellxgene_subset
is_a: CL:0000351 ! trophoblast cell
intersection_of: CL:0000351 ! trophoblast cell
intersection_of: part_of UBERON:0003124 ! chorion membrane
relationship: part_of UBERON:0003124 ! chorion membrane
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0011101" xsd:string {name="chorionic trophoblast cell on CELLxGENE CellGuide"}
[Term]
id: CL:0011103
name: sympathetic neuron
def: "Sympathetic neurons are part of the sympathetic nervous system and are primarily adrenergic producing the neurotransmitter noradrenalin along with other neuropeptides." [GOC:NV, isbn:0080923437]
subset: cellxgene_subset
subset: human_reference_atlas
xref: ZFA:0005777 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000107 ! autonomic neuron
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0011103" xsd:string {name="sympathetic neuron on CELLxGENE CellGuide"}
[Term]
id: CL:0011108
name: colon epithelial cell
def: "Epithelial cell that is part of the colon epithelium." [GOC:NV]
subset: cellxgene_subset
synonym: "colonic epithelial cell" EXACT []
is_a: CL:0002253 ! epithelial cell of large intestine
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0000397 ! colonic epithelium
relationship: part_of UBERON:0000397 ! colonic epithelium
[Term]
id: CL:0011113
name: spiral ganglion neuron
def: "Neuron found in the spiral ganglion." [GOC:NV]
subset: cellxgene_subset
is_a: CL:2000032 ! peripheral nervous system neuron
intersection_of: CL:2000032 ! peripheral nervous system neuron
intersection_of: RO:0002100 UBERON:0000395 ! has soma location cochlear ganglion
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: RO:0002100 UBERON:0000395 ! has soma location cochlear ganglion
[Term]
id: CL:0011115
name: precursor cell
def: "A cell that, by division or terminal differentiation, can give rise to other cell types." [GOC:dos]
comment: Work is needed on GO 'cell differentiation' before it is clear whether the equivalent class definition 'native cell' that capable_of some 'cell differentiation' works. Also, may want to consider merging this with non-terminally differentiated cell.
subset: cellxgene_subset
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: capable_of GO:0030154 ! cell differentiation
relationship: capable_of GO:0030154 ! cell differentiation
[Term]
id: CL:0012000
name: astrocyte of the forebrain
def: "An astrocyte of the forebrain." []
subset: human_reference_atlas
synonym: "forebrain astrocyte" EXACT []
is_a: CL:0000127 {is_inferred="true"} ! astrocyte
is_a: CL:2000005 ! brain macroglial cell
intersection_of: CL:0000127 ! astrocyte
intersection_of: part_of UBERON:0001890 ! forebrain
relationship: dc-contributor https://orcid.org/0000-0002-3837-8864
relationship: part_of UBERON:0001890 ! forebrain
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0012001
name: neuron of the forebrain
def: "A CNS neuron of the forebrain." []
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "forebrain neuron" EXACT []
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0001890 ! has soma location forebrain
relationship: dc-contributor https://orcid.org/0000-0002-3837-8864
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002100 UBERON:0001890 ! has soma location forebrain
[Term]
id: CL:0013000
name: forebrain radial glial cell
def: "Any radial glial cell that is part of some forebrain." [FBC:Autogenerated]
subset: cellxgene_subset
is_a: CL:0000681 ! radial glial cell
intersection_of: CL:0000681 ! radial glial cell
intersection_of: part_of UBERON:0001890 ! forebrain
relationship: part_of UBERON:0001890 ! forebrain
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0013000" xsd:string {name="forebrain radial glial cell on CELLxGENE CellGuide"}
[Term]
id: CL:0017000
name: pulmonary ionocyte
def: "An ionocyte that is part of the lung epithelium. The cells from this type are major sources of the CFTR protein in human and mice." [PMID:30069044, PMID:30069046]
comment: The marker set ASCL3, BSND can identify the Human cell type pulmonary ionocyte in the lung with a confidence of 0.82 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"}
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:0000082 ! epithelial cell of lung
is_a: CL:0005006 ! ionocyte
intersection_of: CL:0005006 ! ionocyte
intersection_of: part_of UBERON:0000115 ! lung epithelium
relationship: dc-contributor https://orcid.org/0000-0003-2473-2313
relationship: part_of UBERON:0000115 ! lung epithelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0015004 CLM:1000032 ! has characterizing marker set
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0017000" xsd:string {name="pulmonary ionocyte on CELLxGENE CellGuide"}
[Term]
id: CL:0017002
name: prostate neuroendocrine cell
def: "A neuroendocrine cell that is part of the prostate epithelium." [http://orcid.org/0000-0001-7772-9578, PMID:33842835]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "neuroendocrine cell of prostate epithelium" EXACT []
synonym: "neuroendocrine cell of the prostate" EXACT []
is_a: CL:0000150 ! glandular secretory epithelial cell
is_a: CL:0000165 ! neuroendocrine cell
intersection_of: CL:0000165 ! neuroendocrine cell
intersection_of: part_of UBERON:0000428 ! prostate epithelium
relationship: dc-contributor http://orcid.org/0000-0003-2473-2313
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: part_of UBERON:0000428 ! prostate epithelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0017003
name: epithelial cell of prostatic urethra
def: "An epithelial cell that is part of the prostatic urethra." [PMID:30566875]
is_a: CL:1000296 ! epithelial cell of urethra
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001335 ! prostatic urethra
relationship: dc-contributor http://orcid.org/0000-0003-2473-2313
relationship: part_of UBERON:0001335 ! prostatic urethra
[Term]
id: CL:0017010
name: hillock cell of urethral epithelium
def: "A hillock cell that is part of the urethra." [http://orcid.org/0000-0001-7772-9578, PMID:30566875]
synonym: "hillock cell of urethra" EXACT []
is_a: CL:1000296 ! epithelial cell of urethra
is_a: CL:4030024 ! hillock cell
intersection_of: CL:4030024 ! hillock cell
intersection_of: part_of UBERON:0000057 ! urethra
relationship: dc-contributor http://orcid.org/0000-0003-2473-2313
relationship: part_of UBERON:0000057 ! urethra
property_value: dcterms-date "2022-10-13T13:51:35Z" xsd:dateTime
[Term]
id: CL:0017011
name: hillock cell of prostatic urethral epithelium
def: "A hillock cell that is part of the prostatic urethra." [http://orcid.org/0000-0001-7772-9578, PMID:30566875]
synonym: "hillock cell of prostatic urethra" EXACT []
is_a: CL:0017003 ! epithelial cell of prostatic urethra
is_a: CL:0017010 ! hillock cell of urethral epithelium
intersection_of: CL:4030024 ! hillock cell
intersection_of: part_of UBERON:0001335 ! prostatic urethra
relationship: dc-contributor http://orcid.org/0000-0003-2473-2313
relationship: part_of UBERON:0001335 ! prostatic urethra
property_value: dcterms-date "2022-10-13T13:58:15Z" xsd:dateTime
[Term]
id: CL:0017500
name: neutrophillic cytoplasm
def: "Cytoplasm that exhibits a characteristic staining and color, pale-pink, with Wright-Giemsa stain." [GOC:add]
is_a: GO:0005737 ! cytoplasm
intersection_of: GO:0005737 ! cytoplasm
intersection_of: RO:0000053 PATO:0070046 ! has characteristic neutrophillic
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: RO:0000053 PATO:0070046 ! has characteristic neutrophillic
creation_date: 2010-05-25T01:36:34Z
[Term]
id: CL:0017502
name: acidophilic cytoplasm
def: "Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain." [GOC:add]
synonym: "eosinophilic" NARROW []
is_a: GO:0005737 ! cytoplasm
intersection_of: GO:0005737 ! cytoplasm
intersection_of: RO:0000053 PATO:0002418 ! has characteristic acidophilic
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: RO:0000053 PATO:0002418 ! has characteristic acidophilic
creation_date: 2009-12-22T04:23:25Z
[Term]
id: CL:0017503
name: basophilic cytoplasm
def: "Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions." [GOC:tfm]
is_a: GO:0005737 ! cytoplasm
intersection_of: GO:0005737 ! cytoplasm
intersection_of: RO:0000053 PATO:0002094 ! has characteristic basophilic
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: RO:0000053 PATO:0002094 ! has characteristic basophilic
creation_date: 2009-12-22T04:24:54Z
[Term]
id: CL:0017504
name: polychromatophilic cytoplasm
def: "Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions." [GOC:tfm]
is_a: GO:0005737 ! cytoplasm
intersection_of: GO:0005737 ! cytoplasm
intersection_of: RO:0000053 PATO:0070047 ! has characteristic polychromatophilic
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: RO:0000053 PATO:0070047 ! has characteristic polychromatophilic
creation_date: 2009-12-28T04:25:23Z
[Term]
id: CL:0017508
name: cartwheel heterochromatin
def: "Heterochromatin that is arranged in a carthwheel pattern." [GOC:tfm]
is_a: GO:0000792 ! heterochromatin
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2009-12-28T04:28:35Z
[Term]
id: CL:0019001
name: tracheobronchial serous cell
def: "Any serous secreting cell that is part of the tracheobronchial epithelium." []
subset: added_for_HCA
subset: cellxgene_subset
synonym: "serous cell of tracheobronchial tree" EXACT []
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000313 ! serous secreting cell
intersection_of: CL:0000313 ! serous secreting cell
intersection_of: part_of UBERON:0007196 ! tracheobronchial tree
relationship: dc-contributor https://orcid.org/0000-0003-2034-601X
relationship: part_of UBERON:0007196 ! tracheobronchial tree
property_value: dcterms-date "2020-05-07T16:03:27Z" xsd:dateTime
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0019001" xsd:string {name="tracheobronchial serous cell on CELLxGENE CellGuide"}
[Term]
id: CL:0019002
name: tracheobronchial chondrocyte
def: "Any chondrocyte that is part of the tracheobronchial tree." []
subset: added_for_HCA
subset: human_reference_atlas
synonym: "chondrocyte of tracheobronchial tree" EXACT []
is_a: CL:0000138 ! chondrocyte
intersection_of: CL:0000138 ! chondrocyte
intersection_of: part_of UBERON:0007196 ! tracheobronchial tree
relationship: dc-contributor https://orcid.org/0000-0003-2034-601X
relationship: part_of UBERON:0007196 ! tracheobronchial tree
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2020-05-07T17:29:51Z" xsd:dateTime
[Term]
id: CL:0019003
name: tracheobronchial goblet cell
def: "Any goblet cell that is part of the tracheobronchial epithelium." []
subset: added_for_HCA
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "goblet cell of tracheobronchial tree" EXACT []
is_a: CL:0002202 ! epithelial cell of tracheobronchial tree
is_a: CL:0002370 ! respiratory tract goblet cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0008397 ! tracheobronchial epithelium
relationship: dc-contributor https://orcid.org/0000-0003-2034-601X
relationship: part_of UBERON:0008397 ! tracheobronchial epithelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2020-05-07T18:14:52Z" xsd:dateTime
[Term]
id: CL:0019017
name: lymphatic vessel smooth muscle cell
def: "A smooth muscle cell that is part of any lymphatic vessel." [PMID:15109561]
subset: human_reference_atlas
synonym: "smooth muscle cell of lymphatic vessel" EXACT []
is_a: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0001473 ! lymphatic vessel
relationship: dc-contributor https://orcid.org/0000-0003-2034-601X
relationship: part_of UBERON:0001473 ! lymphatic vessel
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2020-07-21T12:29:51Z" xsd:dateTime
[Term]
id: CL:0019018
name: blood vessel smooth muscle cell
def: "A smooth muscle cell that is part of any blood vessel." [PMID:9108778]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "smooth muscle cell of blood vessel" EXACT []
is_a: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0001981 ! blood vessel
relationship: dc-contributor https://orcid.org/0000-0003-2034-601X
relationship: part_of UBERON:0001981 ! blood vessel
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2020-07-21T12:42:48Z" xsd:dateTime
[Term]
id: CL:0019019
name: tracheobronchial smooth muscle cell
def: "A smooth muscle cell that is part of the tracheobronchial tree." [PMID:10853867]
comment: The marker set ACTA2, TAGLN can identify the Human cell type tracheobronchial smooth muscle cell in the lung with a confidence of 0.69 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"}
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "smooth muscle cell of tracheobronchial tree" EXACT []
is_a: CL:0000192 ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0007196 ! tracheobronchial tree
relationship: dc-contributor https://orcid.org/0000-0003-2034-601X
relationship: part_of UBERON:0007196 ! tracheobronchial tree
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0015004 CLM:1000056 ! has characterizing marker set
property_value: dcterms-date "2020-07-21T12:50:22Z" xsd:dateTime
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0019019" xsd:string {name="tracheobronchial smooth muscle cell on CELLxGENE CellGuide"}
[Term]
id: CL:0019020
name: extrahepatic cholangiocyte
def: "An epithelial cell of the extrahepatic bile ducts, including the left and right hepatic duct, common hepatic duct, and common bile duct. They are columnar in shape, and have a large nuclear-to-cytoplasmic ratio relative to small/intrahepatic cholangiocytes." [PMID:23720296]
synonym: "large bile duct cholangiocyte" EXACT [PMID:23720296]
is_a: CL:1000488 ! cholangiocyte
intersection_of: CL:1000488 ! cholangiocyte
intersection_of: part_of UBERON:0004822 ! extrahepatic bile duct epithelium
relationship: dc-contributor https://orcid.org/0000-0003-2034-601X
relationship: part_of UBERON:0004822 ! extrahepatic bile duct epithelium
property_value: dcterms-date "2020-09-03T12:24:24Z" xsd:dateTime
[Term]
id: CL:0019021
name: endothelial cell of periportal hepatic sinusoid
def: "An endothelial cell found in the periportal region hepatic sinusoid, near the portal triad. The fenestrae of these cells are larger but fewer in number compared with those of endothelial cells near the centrilobular region of the hepatic sinusoid." [PMID:27423426]
subset: cellxgene_subset
synonym: "periportal hepatic sinusoidal endothelial cell" EXACT [PMID:30348985]
synonym: "periportal LSEC" EXACT [PMID:28287163]
xref: EFO:0010705
is_a: CL:1000398 ! endothelial cell of hepatic sinusoid
intersection_of: CL:1000398 ! endothelial cell of hepatic sinusoid
intersection_of: adjacent_to UBERON:0001279 ! portal triad
relationship: adjacent_to UBERON:0001279 ! portal triad
relationship: dc-contributor https://orcid.org/0000-0003-2034-601X
property_value: dcterms-date "2020-09-09T13:56:47Z" xsd:dateTime
[Term]
id: CL:0019022
name: endothelial cell of pericentral hepatic sinusoid
def: "An endothelial cell found in the centrilobular region hepatic sinusoid, near the central vein. The fenestrae of these cells are smaller but more numerous compared with those of endothelial cells near the periportal region of the hepatic sinusoid." [PMID:27423426]
subset: cellxgene_subset
synonym: "central venous hepatic sinusoidal endothelial cell" EXACT [PMID:30348985]
synonym: "pericentral LSEC" EXACT [PMID:28287163]
xref: EFO:0010706
is_a: CL:1000398 ! endothelial cell of hepatic sinusoid
intersection_of: CL:1000398 ! endothelial cell of hepatic sinusoid
intersection_of: adjacent_to UBERON:0006841 ! central vein of liver
relationship: adjacent_to UBERON:0006841 ! central vein of liver
relationship: dc-contributor https://orcid.org/0000-0003-2034-601X
property_value: dcterms-date "2020-09-10T12:38:29Z" xsd:dateTime
[Term]
id: CL:0019026
name: periportal region hepatocyte
def: "Any hepatocyte that is part of the liver lobule periportal region. These cells are primarily involved in oxidative energy metabolism." [PMID:29763190]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "periportal hepatocyte" EXACT [PMID:29763190]
is_a: CL:0000182 ! hepatocyte
intersection_of: CL:0000182 ! hepatocyte
intersection_of: part_of UBERON:8400006 ! liver lobule periportal region
relationship: dc-contributor https://orcid.org/0000-0003-2034-601X
relationship: part_of UBERON:8400006 ! liver lobule periportal region
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2020-10-12T10:29:31Z" xsd:dateTime
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0019026" xsd:string {name="periportal region hepatocyte on CELLxGENE CellGuide"}
[Term]
id: CL:0019028
name: midzonal region hepatocyte
def: "Any hepatocyte that is part of the liver lobule midzonal region. These cells have mixed functionality in comparison with those in the other two regions of the liver lobule." [PMID:29763190]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "midzonal hepatocyte" EXACT [PMID:29763190]
is_a: CL:0000182 ! hepatocyte
intersection_of: CL:0000182 ! hepatocyte
intersection_of: part_of UBERON:8400008 ! liver lobule midzonal region
relationship: dc-contributor https://orcid.org/0000-0003-2034-601X
relationship: part_of UBERON:8400008 ! liver lobule midzonal region
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2020-10-12T10:57:40Z" xsd:dateTime
[Term]
id: CL:0019029
name: centrilobular region hepatocyte
def: "Any hepatocyte that is part of the liver lobule centrilobular region. These cells are the primary location for the biotransformation of drugs." [PMID:29763190]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "centrilobular hepatocyte" EXACT [PMID:29763190]
is_a: CL:0000182 ! hepatocyte
intersection_of: CL:0000182 ! hepatocyte
intersection_of: part_of UBERON:8400007 ! liver lobule centrilobular region
relationship: dc-contributor https://orcid.org/0000-0003-2034-601X
relationship: part_of UBERON:8400007 ! liver lobule centrilobular region
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2020-10-12T11:03:51Z" xsd:dateTime
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0019029" xsd:string {name="centrilobular region hepatocyte on CELLxGENE CellGuide"}
[Term]
id: CL:0019031
name: intestine goblet cell
def: "Goblet cells reside throughout the length of the small and large intestine and are responsible for the production and maintenance of the protective mucus blanket by synthesizing and secreting high-molecular-weight glycoproteins known as mucins. Human intestinal goblet cells secrete the MUC2 mucin, as well as a number of typical mucus components: CLCA1, FCGBP, AGR2, ZG16, and TFF3." [PMID:1996606, PMID:24942678, PMID:33484640]
subset: cellxgene_subset
synonym: "intestinal goblet cell" EXACT [PMID:1996606]
is_a: CL:0000160 ! goblet cell
is_a: CL:0002563 ! intestinal epithelial cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0001277 ! intestinal epithelium
relationship: dc-contributor https://orcid.org/0000-0003-2034-601X
relationship: develops_from CL:4047017 ! transit amplifying cell of gut
relationship: part_of UBERON:0001277 ! intestinal epithelium
property_value: dcterms-date "2020-10-14T14:59:07Z" xsd:dateTime
[Term]
id: CL:0019032
name: intestinal tuft cell
def: "A tuft cell that is part of the intestinal epithelium, characterized by a distinctive apical tuft and lateral cytospinules connecting to neighbouring cells. This cell senses luminal stimuli via taste receptors and succinate signalling, initiating type 2 immune responses through the secretion of interleukin-25 while modulating epithelial regeneration through prostaglandin synthesis. It expresses key molecular markers such as doublecortin-like kinase 1 (DCLK1) in mice (Hendel et al., 2022), and KIT proto-oncogene in humans (Huang et al., 2024). Developed from intestinal crypt stem cells, this cell requires transcription factor POU2F3 for its development." [PMID:22527717, PMID:29714721, PMID:35237268, PMID:39358509]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "intestinal brush cell" EXACT [PMID:22527717]
is_a: CL:0002204 ! tuft cell
is_a: CL:0002563 ! intestinal epithelial cell
intersection_of: CL:0002204 ! tuft cell
intersection_of: part_of UBERON:0001277 ! intestinal epithelium
relationship: dc-contributor https://orcid.org/0000-0003-2034-601X
relationship: develops_from CL:0002250 ! intestinal crypt stem cell
relationship: part_of UBERON:0001277 ! intestinal epithelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2020-10-15T12:47:46Z" xsd:dateTime
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0019032" xsd:string {name="intestinal tuft cell on CELLxGENE CellGuide"}
[Term]
id: CL:0020011
name: hair follicle associated fibroblast
def: "A specialized dermal fibroblast within the hair follicle mesenchymal compartment that participates in epithelial-mesenchymal signaling to regulate hair morphogenesis, cycling, and homeostasis through production of inductive signals and extracellular matrix maintenance." [PMID:20022473, PMID:34297930]
is_a: CL:0002559 ! hair follicle cell
is_a: CL:0002620 {is_inferred="true"} ! skin fibroblast
intersection_of: CL:0002620 ! skin fibroblast
intersection_of: part_of UBERON:0002073 ! hair follicle
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0002073 ! hair follicle
property_value: dcterms-date "2025-11-04T15:29:55Z" xsd:dateTime
[Term]
id: CL:0020012
name: hair follicle isthmus-associated fibroblast
def: "A fibroblast that is part of the hair follicle isthmus (mid-hair shaft). In humans, this cell expresses CRABP1/COCH/RSPO4 and tendon-associated genes (MKX, TNMD)." [PMID:40993240]
is_a: CL:0020011 ! hair follicle associated fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0006005 ! hair follicle isthmus
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0006005 ! hair follicle isthmus
[Term]
id: CL:0020021
name: fibrochondrocyte progenitor cell
def: "A mesenchymal progenitor cell located in fibrocartilaginous tissues, along the fibrochondrocytic differentiation pathway that co-expresses both fibrochondrocyte markers (COL1A1, COL3A1) and mesenchymal stem cell markers (MCAM/CD146, MYLK) in humans. This cell serves as a progenitor for mature fibrochondrocytes and other meniscal cell types, with differentiation regulated by TGF-β signaling, focal adhesion, and extracellular matrix-receptor interaction pathways." [PMID:31871141, PMID:36338137]
comment: A fibrochondrocyte progenitor cell demonstrates colony-forming capacity and multi-lineage differentiation potential toward osteogenic and adipogenic lineages. {xref="PMID:31871141"}
synonym: "FCP" RELATED OMO:0003000 [PMID:31871141]
is_a: CL:0002320 ! connective tissue cell
is_a: CL:0008019 ! mesenchymal cell
is_a: CL:0011026 ! progenitor cell
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0001995 ! fibrocartilage
[Term]
id: CL:1000001
name: retrotrapezoid nucleus neuron
def: "Any neuron that has its soma located in some retrotrapezoid nucleus." [FBC:Autogenerated]
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0009918 ! has soma location retrotrapezoid nucleus
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: RO:0002100 UBERON:0009918 ! has soma location retrotrapezoid nucleus
[Term]
id: CL:1000022
name: mesonephric nephron tubule epithelial cell
def: "Any epithelial cell that is part of some mesonephric nephron tubule." [FBC:Autogenerated]
subset: cellxgene_subset
is_a: CL:1000449 ! epithelial cell of nephron
is_a: CL:1000507 ! kidney tubule cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0005329 ! mesonephric nephron tubule
relationship: part_of UBERON:0005329 ! mesonephric nephron tubule
[Term]
id: CL:1000042
name: forebrain neuroblast
def: "Any neuroblast (sensu Vertebrata) that is part of some forebrain." [FBC:Autogenerated]
subset: cellxgene_subset
is_a: CL:0000031 ! neuroblast (sensu Vertebrata)
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000031 ! neuroblast (sensu Vertebrata)
intersection_of: part_of UBERON:0001890 ! forebrain
relationship: part_of UBERON:0001890 ! forebrain
[Term]
id: CL:1000050
name: lateral line nerve glial cell
def: "Any glial cell that is part of some lateral line nerve." [FBC:Autogenerated]
is_a: CL:0000125 ! glial cell
intersection_of: CL:0000125 ! glial cell
intersection_of: part_of UBERON:0008906 ! lateral line nerve
relationship: part_of UBERON:0008906 ! lateral line nerve
[Term]
id: CL:1000073
name: spinal cord radial glial cell
def: "Any radial glial cell that is part of some spinal cord." [FBC:Autogenerated]
subset: cellxgene_subset
is_a: CL:0000681 ! radial glial cell
intersection_of: CL:0000681 ! radial glial cell
intersection_of: part_of UBERON:0002240 ! spinal cord
relationship: part_of UBERON:0002240 ! spinal cord
[Term]
id: CL:1000090
name: pronephric nephron tubule epithelial cell
def: "Any epithelial cell that is part of some pronephric nephron tubule." [FBC:Autogenerated]
is_a: CL:1000449 ! epithelial cell of nephron
is_a: CL:1000507 ! kidney tubule cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0005310 ! pronephric nephron tubule
relationship: part_of UBERON:0005310 ! pronephric nephron tubule
[Term]
id: CL:1000123
name: metanephric nephron tubule epithelial cell
def: "Any epithelial cell that is part of some metanephric nephron tubule." [FBC:Autogenerated]
subset: cellxgene_subset
is_a: CL:1000449 ! epithelial cell of nephron
is_a: CL:1000507 ! kidney tubule cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0005146 ! metanephric nephron tubule
relationship: part_of UBERON:0005146 ! metanephric nephron tubule
[Term]
id: CL:1000143
name: lung goblet cell
def: "Any goblet cell that is part of some lung epithelium." [FBC:Autogenerated]
subset: cellxgene_subset
is_a: CL:0000082 ! epithelial cell of lung
is_a: CL:0002370 ! respiratory tract goblet cell
is_a: CL:1000272 ! lung secretory cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0000115 ! lung epithelium
relationship: part_of UBERON:0000115 ! lung epithelium
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000143" xsd:string {name="lung goblet cell on CELLxGENE CellGuide"}
[Term]
id: CL:1000147
name: cardiac valve cell
def: "A cell that is part of a cardiac valve." [PMID:25311230]
subset: cellxgene_subset
synonym: "heart valve cell" EXACT [PMID:30796046]
xref: ZFA:0009402 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0002494 ! cardiocyte
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0000946 ! cardiac valve
relationship: part_of UBERON:0000946 ! cardiac valve
[Term]
id: CL:1000217
name: growth plate cartilage chondrocyte
def: "Any chondrocyte that is part of some growth plate cartilage." [FBC:Autogenerated]
is_a: CL:0000138 ! chondrocyte
intersection_of: CL:0000138 ! chondrocyte
intersection_of: part_of UBERON:0004129 ! growth plate cartilage
relationship: part_of UBERON:0004129 ! growth plate cartilage
[Term]
id: CL:1000222
name: stomach neuroendocrine cell
def: "A specialised neuroendocrine cell located in the gastric mucosa that regulates digestive processes including acid secretion and gut motility. This cell stores hormones in large dense core vesicles and synaptic-like microvesicles." [PMID:15153415]
synonym: "DES cell" BROAD [PMID:15153415]
synonym: "diffuse endocrine system cell" BROAD [PMID:15153415]
is_a: CL:0000165 ! neuroendocrine cell
is_a: CL:1001517 ! stomach enteroendocrine cell
intersection_of: CL:0000165 ! neuroendocrine cell
intersection_of: part_of UBERON:0001276 ! epithelium of stomach
relationship: capable_of GO:0046717 ! acid secretion
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: part_of UBERON:0001276 ! epithelium of stomach
[Term]
id: CL:1000223
name: pulmonary neuroendocrine cell
def: "A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Pulmonary neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Pulmonary neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury." [doi:10.3109/01902148209069653, doi:10.7554/eLife.78216, PMID:33355253]
comment: The marker set CHGA, GRP can identify the Human cell type pulmonary neuroendocrine cell in the lung with a confidence of 0.94 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"}
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "lung neuroendocrine cell" EXACT [PMID:15018448]
synonym: "PNEC" RELATED OMO:0003000 [PMID:33355253]
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000098 ! sensory epithelial cell
is_a: CL:0000165 ! neuroendocrine cell
is_a: CL:0000206 ! chemoreceptor cell
is_a: CL:0000458 ! serotonin secreting cell
is_a: CL:1000272 ! lung secretory cell
intersection_of: CL:0000165 ! neuroendocrine cell
intersection_of: part_of UBERON:0002048 ! lung
relationship: capable_of GO:0070483 ! detection of hypoxia
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: has_part GO:0031045 ! dense core granule
relationship: part_of UBERON:0002048 ! lung
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0015004 CLM:1000043 ! has characterizing marker set
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000223" xsd:string {name="pulmonary neuroendocrine cell on CELLxGENE CellGuide"}
[Term]
id: CL:1000236
name: posterior lateral line nerve glial cell
def: "Any glial cell that is part of some posterior lateral line nerve." [FBC:Autogenerated]
is_a: CL:1000050 ! lateral line nerve glial cell
intersection_of: CL:0000125 ! glial cell
intersection_of: part_of UBERON:2000175 ! posterior lateral line nerve
relationship: part_of UBERON:2000175 ! posterior lateral line nerve
[Term]
id: CL:1000239
name: anterior lateral line nerve glial cell
def: "Any glial cell that is part of some anterior lateral line nerve." [FBC:Autogenerated]
is_a: CL:1000050 ! lateral line nerve glial cell
intersection_of: CL:0000125 ! glial cell
intersection_of: part_of UBERON:2000425 ! anterior lateral line nerve
relationship: part_of UBERON:2000425 ! anterior lateral line nerve
[Term]
id: CL:1000245
name: posterior lateral line ganglion neuron
def: "Any peripheral nervous system neuron that has its soma located in some posterior lateral line ganglion." [FBC:Autogenerated]
is_a: CL:2000031 ! lateral line ganglion neuron
intersection_of: CL:2000032 ! peripheral nervous system neuron
intersection_of: RO:0002100 UBERON:2001314 ! has soma location posterior lateral line ganglion
relationship: RO:0002100 UBERON:2001314 ! has soma location posterior lateral line ganglion
[Term]
id: CL:1000271
name: lung multiciliated epithelial cell
def: "An epithelial cell that is part of the lung epithelium. This cell is characterised by the presence of cilia on its apical surface." [PMID:27864314]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "lung ciliated cell" EXACT []
is_a: CL:0000082 ! epithelial cell of lung
is_a: CL:4030034 ! respiratory tract multiciliated cell
intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell
intersection_of: has_part GO:0031514 ! motile cilium
intersection_of: part_of UBERON:0000115 ! lung epithelium
intersection_of: RO:0000053 PATO:0010007 ! has characteristic multiciliated
relationship: has_part GO:0031514 ! motile cilium
relationship: part_of UBERON:0000115 ! lung epithelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0000053 PATO:0010007 ! has characteristic multiciliated
[Term]
id: CL:1000272
name: lung secretory cell
def: "Any secretory cell that is part of some lung." [FBC:Autogenerated]
subset: cellxgene_subset
is_a: CL:0000151 ! secretory cell
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0002048 ! lung
[Term]
id: CL:1000274
name: trophectodermal cell
def: "An extraembryonic cell that is part of the trophectoderm, representing the first lineage to differentiate in the embryo. This cell is crucial for implantation into the uterine wall and differentiates into trophoblast cells, which contribute to placenta formation and facilitate maternal-fetal nutrient and signal exchange." [PMID:22918806]
synonym: "trophectoderm cell" EXACT []
is_a: CL:0000349 ! extraembryonic cell
intersection_of: CL:0000349 ! extraembryonic cell
intersection_of: part_of UBERON:0004345 ! trophectoderm
relationship: develops_into CL:0000351 ! trophoblast cell
relationship: part_of UBERON:0004345 ! trophectoderm
[Term]
id: CL:1000275
name: smooth muscle cell of small intestine
def: "A smooth muscle cell that is part of the small intestine." [GOC:tfm]
subset: cellxgene_subset
synonym: "non-striated muscle fiber of small intestine" EXACT [FMA:15050]
xref: FMA:15050
is_a: CL:0002504 {is_inferred="true"} ! enteric smooth muscle cell
intersection_of: CL:0002504 ! enteric smooth muscle cell
intersection_of: part_of UBERON:0002108 ! small intestine
relationship: part_of UBERON:0002108 ! small intestine
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000275" xsd:string {name="smooth muscle cell of small intestine on CELLxGENE CellGuide"}
[Term]
id: CL:1000276
name: smooth muscle fiber of duodenum
def: "A smooth muscle cell that is part of the duodenum." [GOC:tfm]
synonym: "non-striated muscle fiber of duodenum" EXACT [FMA:15058]
xref: FMA:15058
is_a: CL:1000275 {is_inferred="true"} ! smooth muscle cell of small intestine
intersection_of: CL:1000275 ! smooth muscle cell of small intestine
intersection_of: part_of UBERON:0002114 ! duodenum
relationship: part_of UBERON:0001902 ! epithelium of small intestine
relationship: part_of UBERON:0002114 ! duodenum
[Term]
id: CL:1000277
name: smooth muscle fiber of jejunum
def: "A smooth muscle cell that is part of the jejunum." [GOC:tfm]
synonym: "non-striated muscle fiber of jejunum" EXACT [FMA:15062]
xref: FMA:15062
is_a: CL:1000275 {is_inferred="true"} ! smooth muscle cell of small intestine
intersection_of: CL:1000275 ! smooth muscle cell of small intestine
intersection_of: part_of UBERON:0002115 ! jejunum
relationship: part_of UBERON:0002115 ! jejunum
[Term]
id: CL:1000278
name: smooth muscle fiber of ileum
def: "A smooth muscle cell that is part of the ileum." [GOC:tfm]
subset: cellxgene_subset
synonym: "non-striated muscle fiber of ileum" EXACT [FMA:15066]
xref: FMA:15066
is_a: CL:1000275 {is_inferred="true"} ! smooth muscle cell of small intestine
intersection_of: CL:1000275 ! smooth muscle cell of small intestine
intersection_of: part_of UBERON:0002116 ! ileum
relationship: part_of UBERON:0001902 ! epithelium of small intestine
relationship: part_of UBERON:0002116 ! ileum
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000278" xsd:string {name="smooth muscle fiber of ileum on CELLxGENE CellGuide"}
[Term]
id: CL:1000279
name: smooth muscle cell of large intestine
def: "A smooth muscle cell that is part of the large intestine." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "non-striated muscle fiber of large intestine" EXACT [FMA:15653]
xref: FMA:15653
is_a: CL:0002504 {is_inferred="true"} ! enteric smooth muscle cell
intersection_of: CL:0002504 ! enteric smooth muscle cell
intersection_of: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0000059 ! large intestine
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1000280
name: smooth muscle cell of colon
def: "A smooth muscle cell that is part of the colon." [GOC:tfm]
synonym: "non-striated muscle fiber of colon" EXACT [FMA:15663]
xref: FMA:15663
is_a: CL:1000279 ! smooth muscle cell of large intestine
intersection_of: CL:0002504 ! enteric smooth muscle cell
intersection_of: part_of UBERON:0001155 ! colon
relationship: part_of UBERON:0001155 ! colon
relationship: part_of UBERON:0001278 ! epithelium of large intestine
[Term]
id: CL:1000281
name: smooth muscle cell of cecum
def: "A smooth muscle cell that is part of the cecum." [GOC:tfm]
synonym: "non-striated muscle fiber of cecum" EXACT [FMA:15681]
synonym: "smooth muscle fiber of cecum" EXACT []
xref: FMA:15681
is_a: CL:1000280 ! smooth muscle cell of colon
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0001153 ! caecum
relationship: part_of UBERON:0001153 ! caecum
[Term]
id: CL:1000282
name: smooth muscle fiber of ascending colon
def: "A smooth muscle cell that is part of the ascending colon." [GOC:tfm]
synonym: "non-striated muscle fiber of ascending colon" EXACT [FMA:17518]
xref: FMA:17518
is_a: CL:1000280 {is_inferred="true"} ! smooth muscle cell of colon
intersection_of: CL:1000280 ! smooth muscle cell of colon
intersection_of: part_of UBERON:0001156 ! ascending colon
relationship: part_of UBERON:0001156 ! ascending colon
[Term]
id: CL:1000283
name: smooth muscle fiber of transverse colon
def: "A smooth muscle cell that is part of the transverse colon." [GOC:tfm]
synonym: "non-striated muscle fiber of transverse colon" EXACT [FMA:17519]
xref: FMA:17519
is_a: CL:1000280 {is_inferred="true"} ! smooth muscle cell of colon
intersection_of: CL:1000280 ! smooth muscle cell of colon
intersection_of: part_of UBERON:0001157 ! transverse colon
relationship: part_of UBERON:0001157 ! transverse colon
[Term]
id: CL:1000284
name: smooth muscle fiber of descending colon
def: "A smooth muscle cell that is part of the descending colon." [GOC:tfm]
synonym: "non-striated muscle fiber of descending colon" EXACT [FMA:17520]
xref: FMA:17520
is_a: CL:1000280 {is_inferred="true"} ! smooth muscle cell of colon
intersection_of: CL:1000280 ! smooth muscle cell of colon
intersection_of: part_of UBERON:0001158 ! descending colon
relationship: part_of UBERON:0001158 ! descending colon
[Term]
id: CL:1000285
name: smooth muscle cell of sigmoid colon
def: "A smooth muscle cell that is part of the sigmoid colon." [GOC:tfm]
synonym: "non-striated muscle fiber of sigmoid colon" EXACT [FMA:17521]
xref: FMA:17521
is_a: CL:1000280 {is_inferred="true"} ! smooth muscle cell of colon
intersection_of: CL:1000280 ! smooth muscle cell of colon
intersection_of: part_of UBERON:0001159 ! sigmoid colon
relationship: part_of UBERON:0001159 ! sigmoid colon
[Term]
id: CL:1000286
name: smooth muscle cell of rectum
def: "A smooth muscle cell that is part of the rectum." [GOC:tfm]
synonym: "non-striated muscle fiber of rectum" EXACT [FMA:17522]
synonym: "smooth muscle fiber of rectum" EXACT []
xref: FMA:17522
is_a: CL:1000279 ! smooth muscle cell of large intestine
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0001052 ! rectum
relationship: part_of UBERON:0001052 ! rectum
relationship: part_of UBERON:0001278 ! epithelium of large intestine
[Term]
id: CL:1000296
name: epithelial cell of urethra
def: "An epithelial cell that is part of the urethra." [GOC:tfm]
subset: cellxgene_subset
xref: FMA:256165
is_a: CL:0000066 ! epithelial cell
is_a: CL:1001320 ! urethra cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0000057 ! urethra
relationship: part_of UBERON:0000057 ! urethra
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000296" xsd:string {name="epithelial cell of urethra on CELLxGENE CellGuide"}
[Term]
id: CL:1000298
name: mesothelial cell of dura mater
def: "A mesothelial cell that is part of the dura mater." [GOC:tfm]
subset: cellxgene_subset
synonym: "squamous mesothelial cell of dura mater" EXACT [FMA:256516]
xref: FMA:256516
is_a: CL:0000077 ! mesothelial cell
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0002363 ! dura mater
relationship: part_of UBERON:0002363 ! dura mater
[Term]
id: CL:1000302
name: fibroblast of papillary layer of dermis
def: "A fibroblast that is part of the papillary layer of dermis." [GOC:tfm]
xref: FMA:261277
is_a: CL:0002551 {is_inferred="true"} ! fibroblast of dermis
intersection_of: CL:0002551 ! fibroblast of dermis
intersection_of: part_of UBERON:0001992 ! papillary layer of dermis
relationship: part_of UBERON:0001992 ! papillary layer of dermis
[Term]
id: CL:1000303
name: fibroblast of areolar connective tissue
def: "A fibroblast that is part of the areolar connective tissue." [GOC:tfm]
xref: FMA:261279
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0006815 ! areolar connective tissue
relationship: part_of UBERON:0006815 ! areolar connective tissue
[Term]
id: CL:1000306
name: fibroblast of tunica adventitia of artery
def: "A fibroblast that is part of the tunica adventitia of artery." [GOC:tfm]
xref: FMA:261285
is_a: CL:4052030 ! adventitial fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0007240 ! tunica adventitia of artery
relationship: part_of UBERON:0007240 ! tunica adventitia of artery
[Term]
id: CL:1000307
name: fibroblast of dense regular elastic tissue
def: "A fibroblast that is part of the dense regular elastic tissue." [GOC:tfm]
xref: FMA:261287
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0007846 ! dense regular connective tissue
relationship: part_of UBERON:0002521 ! elastic tissue
relationship: part_of UBERON:0007846 ! dense regular connective tissue
[Term]
id: CL:1000309
name: epicardial adipocyte
def: "An adipocyte that is part of the epicardial fat." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "adipocyte of epicardial fat" EXACT [FMA:261293]
synonym: "epicardial fat cell" EXACT [FMA:261293]
xref: FMA:261293
is_a: CL:0000136 ! adipocyte
is_a: CL:0002494 ! cardiocyte
relationship: part_of UBERON:0002348 ! epicardium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000309" xsd:string {name="epicardial adipocyte on CELLxGENE CellGuide"}
[Term]
id: CL:1000310
name: adipocyte of epicardial fat of right ventricle
def: "An adipocyte that is part of the epicardial fat of right ventricle." [GOC:tfm]
synonym: "epicardial adipocyte of right ventricle" EXACT [FMA:261297]
synonym: "epicardial fat cell of right ventricle" EXACT [FMA:261297]
xref: FMA:261297
is_a: CL:1000309 ! epicardial adipocyte
intersection_of: CL:1000309 ! epicardial adipocyte
intersection_of: part_of UBERON:0002080 ! heart right ventricle
relationship: part_of UBERON:0002080 ! heart right ventricle
[Term]
id: CL:1000311
name: adipocyte of epicardial fat of left ventricle
def: "An adipocyte that is part of the epicardial fat of left ventricle." [GOC:tfm]
subset: cellxgene_subset
synonym: "epicardial adipocyte of left ventricle" EXACT [FMA:261300]
synonym: "epicardial fat cell of left ventricle" EXACT [FMA:261300]
xref: FMA:261300
is_a: CL:1000309 ! epicardial adipocyte
intersection_of: CL:1000309 ! epicardial adipocyte
intersection_of: part_of UBERON:0002084 ! heart left ventricle
relationship: part_of UBERON:0002084 ! heart left ventricle
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000311" xsd:string {name="adipocyte of epicardial fat of left ventricle on CELLxGENE CellGuide"}
[Term]
id: CL:1000312
name: bronchial goblet cell
def: "A goblet cell that is part of the epithelium of bronchus." [GOC:tfm]
comment: The marker set PLCG2, ANKRD36C can identify the Human cell type bronchial goblet cell in the lung with a confidence of 0.55 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"}
subset: cellxgene_subset
synonym: "goblet cell of epithelium of bronchus" EXACT [FMA:263032]
xref: FMA:263032
is_a: CL:0002328 ! bronchial epithelial cell
is_a: CL:0019003 ! tracheobronchial goblet cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0002185 ! bronchus
relationship: part_of UBERON:0002185 ! bronchus
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0015004 CLM:1000026 ! has characterizing marker set
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000312" xsd:string {name="bronchial goblet cell on CELLxGENE CellGuide"}
[Term]
id: CL:1000313
name: gastric goblet cell
def: "A goblet cell that is part of the epithelium of stomach." [GOC:tfm]
synonym: "goblet cell of epithelium of stomach" EXACT [FMA:263035]
xref: FMA:263035
is_a: CL:0000160 ! goblet cell
is_a: CL:0002180 ! mucous cell of stomach
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0000945 ! stomach
relationship: part_of UBERON:0000945 ! stomach
[Term]
id: CL:1000314
name: gastric cardiac gland goblet cell
def: "A goblet cell that is part of the epithelium of gastric cardiac gland." [GOC:tfm]
synonym: "goblet cell of epithelium of gastric cardiac gland" EXACT []
xref: FMA:263038
is_a: CL:0000152 ! exocrine cell
is_a: CL:0002659 ! glandular epithelial cell of stomach
is_a: CL:1000313 ! gastric goblet cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0008859 ! cardiac gastric gland
relationship: part_of UBERON:0008859 ! cardiac gastric gland
[Term]
id: CL:1000315
name: principal gastric gland goblet cell
def: "A goblet cell that is part of the epithelium of principal gastric gland." [GOC:tfm]
synonym: "goblet cell of epithelium of principal gastric gland" EXACT []
xref: FMA:263040
is_a: CL:0000152 ! exocrine cell
is_a: CL:0002659 ! glandular epithelial cell of stomach
is_a: CL:1000313 ! gastric goblet cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0009971 ! principal gastric gland
relationship: part_of UBERON:0009971 ! principal gastric gland
[Term]
id: CL:1000317
name: intestinal villus goblet cell
def: "A goblet cell that is part of the epithelium of intestinal villus." [GOC:tfm]
synonym: "goblet cell of epithelium of intestinal villus" EXACT []
xref: FMA:263046
is_a: CL:1000495 ! small intestine goblet cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0013636 ! epithelium of intestinal villus
relationship: part_of UBERON:0013636 ! epithelium of intestinal villus
[Term]
id: CL:1000320
name: large intestine goblet cell
def: "A goblet cell that is part of the epithelium of large intestine." [GOC:tfm]
subset: cellxgene_subset
synonym: "goblet cell of epithelium of large intestine" EXACT []
xref: FMA:263054
is_a: CL:0002253 ! epithelial cell of large intestine
is_a: CL:0019031 ! intestine goblet cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0001278 ! epithelium of large intestine
relationship: part_of UBERON:0001278 ! epithelium of large intestine
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000320" xsd:string {name="large intestine goblet cell on CELLxGENE CellGuide"}
[Term]
id: CL:1000321
name: large intestine crypt goblet cell
def: "A goblet cell that is part of the epithelium of crypt of Lieberkuhn of large intestine." [GOC:tfm]
subset: human_reference_atlas
xref: FMA:263056
is_a: CL:0002658 ! glandular cell of the large intestine
is_a: CL:1000320 ! large intestine goblet cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0022281 ! epithelium of crypt of Lieberkuhn of large intestine
relationship: part_of UBERON:0022281 ! epithelium of crypt of Lieberkuhn of large intestine
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1000322
name: pancreatic goblet cell
def: "A goblet cell that is part of the epithelium of pancreatic duct." [GOC:tfm]
subset: human_reference_atlas
synonym: "goblet cell of epithelium of pancreatic duct" EXACT [FMA:263058]
xref: FMA:263058
is_a: CL:0000069 ! branched duct epithelial cell
is_a: CL:0000160 ! goblet cell
is_a: CL:1001599 ! pancreas exocrine glandular cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0001264 ! pancreas
relationship: part_of UBERON:0001264 ! pancreas
relationship: part_of UBERON:0009970 ! epithelium of pancreatic duct
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1000323
name: pyloric gastric gland goblet cell
def: "A goblet cell that is part of the epithelium of pyloric gland." [GOC:tfm]
synonym: "goblet cell of epithelium of pyloric gland" EXACT []
xref: FMA:263061
is_a: CL:0000152 ! exocrine cell
is_a: CL:0002659 ! glandular epithelial cell of stomach
is_a: CL:1000313 ! gastric goblet cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0008861 ! pyloric gastric gland
relationship: part_of UBERON:0005637 ! pyloric region epithelium
relationship: part_of UBERON:0008861 ! pyloric gastric gland
[Term]
id: CL:1000324
name: duodenal goblet cell
def: "A goblet cell that is part of the epithelium proper of duodenum." [GOC:tfm]
subset: human_reference_atlas
synonym: "goblet cell of epithelium proper of duodenum" EXACT []
xref: FMA:263063
is_a: CL:1000317 ! intestinal villus goblet cell
is_a: CL:1001589 ! duodenum secretory cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0008346 ! duodenal epithelium
relationship: part_of UBERON:0008346 ! duodenal epithelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1000325
name: jejunal goblet cell
def: "A goblet cell that is part of the epithelium proper of jejunum." [GOC:tfm]
subset: human_reference_atlas
synonym: "goblet cell of epithelium proper of jejunum" EXACT []
xref: FMA:263065
is_a: CL:1000317 ! intestinal villus goblet cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0000400 ! jejunal epithelium
relationship: part_of UBERON:0000400 ! jejunal epithelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1000326
name: ileal goblet cell
def: "A goblet cell that is part of the epithelium proper of ileum." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "goblet cell of epithelium proper of ileum" EXACT []
xref: FMA:263067
is_a: CL:1000317 ! intestinal villus goblet cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0008345 ! ileal epithelium
relationship: part_of UBERON:0008345 ! ileal epithelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000326" xsd:string {name="ileal goblet cell on CELLxGENE CellGuide"}
[Term]
id: CL:1000327
name: appendix goblet cell
def: "A goblet cell that is part of the epithelium proper of appendix." [GOC:tfm]
synonym: "goblet cell of epithelium proper of appendix" EXACT []
xref: FMA:263069
is_a: CL:1000320 ! large intestine goblet cell
is_a: CL:1000405 ! epithelial cell of appendix
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0009697 ! epithelium of appendix
relationship: part_of UBERON:0009697 ! epithelium of appendix
[Term]
id: CL:1000329
name: tracheal goblet cell
def: "A goblet cell that is part of the epithelium of trachea." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "goblet cell of epithelium of trachea" EXACT [FMA:263075]
xref: FMA:263075
is_a: CL:0000307 ! tracheal epithelial cell
is_a: CL:0019003 ! tracheobronchial goblet cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0003126 ! trachea
relationship: part_of UBERON:0001901 ! epithelium of trachea
relationship: part_of UBERON:0003126 ! trachea
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000329" xsd:string {name="tracheal goblet cell on CELLxGENE CellGuide"}
[Term]
id: CL:1000330
name: serous cell of epithelium of trachea
def: "A serous secreting cell that is part of the epithelium of trachea." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
xref: FMA:263078
is_a: CL:0019001 ! tracheobronchial serous cell
intersection_of: CL:0000313 ! serous secreting cell
intersection_of: part_of UBERON:0001901 ! epithelium of trachea
relationship: part_of UBERON:0001901 ! epithelium of trachea
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000330" xsd:string {name="serous cell of epithelium of trachea on CELLxGENE CellGuide"}
[Term]
id: CL:1000331
name: serous cell of epithelium of bronchus
def: "A serous secreting cell that is part of the epithelium of bronchus." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
xref: FMA:263080
is_a: CL:0019001 ! tracheobronchial serous cell
intersection_of: CL:0000313 ! serous secreting cell
intersection_of: part_of UBERON:0002031 ! epithelium of bronchus
relationship: part_of UBERON:0002031 ! epithelium of bronchus
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000331" xsd:string {name="serous cell of epithelium of bronchus on CELLxGENE CellGuide"}
[Term]
id: CL:1000332
name: serous cell of epithelium of terminal bronchiole
def: "A serous secreting cell that is part of the epithelium of terminal bronchiole." [GOC:tfm]
xref: FMA:263082
is_a: CL:0019001 ! tracheobronchial serous cell
is_a: CL:1000272 ! lung secretory cell
intersection_of: CL:0000313 ! serous secreting cell
intersection_of: part_of UBERON:0001958 ! terminal bronchiole epithelium
relationship: part_of UBERON:0001958 ! terminal bronchiole epithelium
[Term]
id: CL:1000333
name: serous cell of epithelium of lobular bronchiole
def: "A serous secreting cell that is part of the epithelium of bronchiole." [GOC:tfm]
subset: cellxgene_subset
xref: FMA:263084
is_a: CL:0019001 ! tracheobronchial serous cell
is_a: CL:1000272 ! lung secretory cell
intersection_of: CL:0000313 ! serous secreting cell
intersection_of: part_of UBERON:8600001 ! epithelium of lobular bronchiole
relationship: part_of UBERON:8600001 ! epithelium of lobular bronchiole
[Term]
id: CL:1000348
name: basal cell of epithelium of trachea
def: "A basal cell that is part of the epithelium of trachea." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
xref: FMA:263118
is_a: CL:0002633 {is_inferred="true"} ! respiratory basal cell
intersection_of: CL:0002633 ! respiratory basal cell
intersection_of: part_of UBERON:0001901 ! epithelium of trachea
relationship: part_of UBERON:0001901 ! epithelium of trachea
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000348" xsd:string {name="basal cell of epithelium of trachea on CELLxGENE CellGuide"}
[Term]
id: CL:1000349
name: basal cell of epithelium of bronchus
def: "A basal cell found in the bronchus epithelium." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "basal cell of bronchus" EXACT []
xref: FMA:263120
is_a: CL:0002328 ! bronchial epithelial cell
is_a: CL:0002329 ! basal epithelial cell of tracheobronchial tree
is_a: CL:0002633 ! respiratory basal cell
intersection_of: CL:0002633 ! respiratory basal cell
intersection_of: part_of UBERON:0002031 ! epithelium of bronchus
relationship: part_of UBERON:0002031 ! epithelium of bronchus
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000349" xsd:string {name="basal cell of epithelium of bronchus on CELLxGENE CellGuide"}
[Term]
id: CL:1000350
name: basal cell of epithelium of terminal bronchiole
def: "A basal cell that is part of the epithelium of terminal bronchiole." [GOC:tfm]
subset: human_reference_atlas
xref: FMA:263122
is_a: CL:0002633 {is_inferred="true"} ! respiratory basal cell
intersection_of: CL:0002633 ! respiratory basal cell
intersection_of: part_of UBERON:0001958 ! terminal bronchiole epithelium
relationship: part_of UBERON:0001958 ! terminal bronchiole epithelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1000351
name: basal cell of epithelium of respiratory bronchiole
def: "A basal cell that is part of the epithelium of respiratory bronchiole." [GOC:tfm]
subset: human_reference_atlas
xref: FMA:263124
is_a: CL:0002633 {is_inferred="true"} ! respiratory basal cell
intersection_of: CL:0002633 ! respiratory basal cell
intersection_of: part_of UBERON:0001955 ! epithelium of respiratory bronchiole
relationship: part_of UBERON:0001955 ! epithelium of respiratory bronchiole
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1000352
name: basal cell of epithelium of lobular bronchiole
def: "A basal cell that is part of the epithelium of bronchiole." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
xref: FMA:263126
is_a: CL:0002633 {is_inferred="true"} ! respiratory basal cell
intersection_of: CL:0002633 ! respiratory basal cell
intersection_of: part_of UBERON:8600001 ! epithelium of lobular bronchiole
relationship: part_of UBERON:8600001 ! epithelium of lobular bronchiole
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1000361
name: transitional myocyte of interatrial septum
def: "A transitional myocyte that is part of the interatrial septum." [GOC:tfm]
xref: FMA:263152
is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte
is_a: CL:2000022 ! cardiac septum cell
intersection_of: CL:0002073 ! transitional myocyte
intersection_of: part_of UBERON:0002085 ! interatrial septum
relationship: part_of UBERON:0002085 ! interatrial septum
[Term]
id: CL:1000362
name: transitional myocyte of interventricular septum
def: "A transitional myocyte that is part of the interventricular septum." [GOC:tfm]
xref: FMA:263154
is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte
is_a: CL:2000022 ! cardiac septum cell
intersection_of: CL:0002073 ! transitional myocyte
intersection_of: part_of UBERON:0002094 ! interventricular septum
relationship: part_of UBERON:0002094 ! interventricular septum
[Term]
id: CL:1000370
name: transitional myocyte of left branch of atrioventricular bundle
def: "A transitional myocyte that is part of the left branch of atrioventricular bundle." [GOC:tfm]
xref: FMA:263170
is_a: CL:1000481 ! transitional myocyte of atrioventricular bundle
intersection_of: CL:0002073 ! transitional myocyte
intersection_of: part_of UBERON:0005986 ! left bundle branch
relationship: part_of UBERON:0005986 ! left bundle branch
[Term]
id: CL:1000371
name: transitional myocyte of right branch of atrioventricular bundle
def: "A transitional myocyte that is part of the right branch of atrioventricular bundle." [GOC:tfm]
xref: FMA:263172
is_a: CL:1000481 ! transitional myocyte of atrioventricular bundle
intersection_of: CL:0002073 ! transitional myocyte
intersection_of: part_of UBERON:0005987 ! right bundle branch
relationship: part_of UBERON:0005987 ! right bundle branch
[Term]
id: CL:1000376
name: Purkinje myocyte of interventricular septum
def: "A Purkinje myocyte that is part of the interventricular septum." [GOC:tfm]
xref: FMA:263182
is_a: CL:0002068 {is_inferred="true"} ! Purkinje myocyte
is_a: CL:2000022 ! cardiac septum cell
intersection_of: CL:0002068 ! Purkinje myocyte
intersection_of: part_of UBERON:0002094 ! interventricular septum
relationship: part_of UBERON:0002094 ! interventricular septum
[Term]
id: CL:1000378
name: type 1 vestibular sensory cell of stato-acoustic epithelium
def: "A type I vestibular sensory cell that is part of the stato-acoustic epithelium." [GOC:tfm]
xref: FMA:263186
is_a: CL:0002070 ! type I vestibular sensory cell
is_a: CL:3000004 ! peripheral sensory neuron
intersection_of: CL:0002070 ! type I vestibular sensory cell
intersection_of: part_of UBERON:0009969 ! statoacoustic epithelium
relationship: part_of UBERON:0009969 ! statoacoustic epithelium
[Term]
id: CL:1000379
name: type 1 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth
def: "A type I vestibular sensory cell that is part of the epithelium of macula of utricle of membranous labyrinth." [GOC:tfm]
xref: FMA:263188
is_a: CL:0002070 ! type I vestibular sensory cell
is_a: CL:3000004 ! peripheral sensory neuron
intersection_of: CL:0002070 ! type I vestibular sensory cell
intersection_of: part_of UBERON:0002214 ! macula of utricle of membranous labyrinth
relationship: part_of UBERON:0002214 ! macula of utricle of membranous labyrinth
relationship: part_of UBERON:0003241 ! epithelium of utricle
[Term]
id: CL:1000380
name: type 1 vestibular sensory cell of epithelium of macula of saccule of membranous labyrinth
def: "A type I vestibular sensory cell that is part of the epithelium of macula of saccule of membranous labyrinth." [GOC:tfm]
xref: FMA:263190
is_a: CL:0002070 ! type I vestibular sensory cell
is_a: CL:3000004 ! peripheral sensory neuron
intersection_of: CL:0002070 ! type I vestibular sensory cell
intersection_of: part_of UBERON:0002212 ! macula of saccule of membranous labyrinth
relationship: part_of UBERON:0002212 ! macula of saccule of membranous labyrinth
relationship: part_of UBERON:0003242 ! epithelium of saccule
[Term]
id: CL:1000381
name: type 1 vestibular sensory cell of epithelium of crista of ampulla of semicircular duct of membranous labyrinth
def: "A type I vestibular sensory cell that is part of the epithelium of crista of ampulla of semicircular duct of membranous labyrinth." [GOC:tfm]
xref: FMA:263192
is_a: CL:0002070 ! type I vestibular sensory cell
is_a: CL:3000004 ! peripheral sensory neuron
intersection_of: CL:0002070 ! type I vestibular sensory cell
intersection_of: part_of UBERON:0006935 ! crista ampullaris neuroepithelium
relationship: part_of UBERON:0006935 ! crista ampullaris neuroepithelium
[Term]
id: CL:1000382
name: type 2 vestibular sensory cell of stato-acoustic epithelium
def: "A type II vestibular sensory cell that is part of the stato-acoustic epithelium." [GOC:tfm]
xref: FMA:263194
is_a: CL:0002069 ! type II vestibular sensory cell
is_a: CL:3000004 ! peripheral sensory neuron
intersection_of: CL:0002069 ! type II vestibular sensory cell
intersection_of: part_of UBERON:0009969 ! statoacoustic epithelium
relationship: part_of UBERON:0009969 ! statoacoustic epithelium
[Term]
id: CL:1000383
name: type 2 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth
def: "A type II vestibular sensory cell that is part of the epithelium of macula of utricle of membranous labyrinth." [GOC:tfm]
xref: FMA:263196
is_a: CL:0002069 ! type II vestibular sensory cell
is_a: CL:3000004 ! peripheral sensory neuron
intersection_of: CL:0002069 ! type II vestibular sensory cell
intersection_of: part_of UBERON:0002214 ! macula of utricle of membranous labyrinth
relationship: part_of UBERON:0002214 ! macula of utricle of membranous labyrinth
relationship: part_of UBERON:0003241 ! epithelium of utricle
[Term]
id: CL:1000384
name: type 2 vestibular sensory cell of epithelium of macula of saccule of membranous labyrinth
def: "A type II vestibular sensory cell that is part of the epithelium of macula of saccule of membranous labyrinth." [GOC:tfm]
xref: FMA:263198
is_a: CL:0002069 ! type II vestibular sensory cell
is_a: CL:3000004 ! peripheral sensory neuron
intersection_of: CL:0002069 ! type II vestibular sensory cell
intersection_of: part_of UBERON:0002212 ! macula of saccule of membranous labyrinth
relationship: part_of UBERON:0002212 ! macula of saccule of membranous labyrinth
relationship: part_of UBERON:0003242 ! epithelium of saccule
[Term]
id: CL:1000385
name: type 2 vestibular sensory cell of epithelium of crista of ampulla of semicircular duct of membranous labyrinth
def: "A type II vestibular sensory cell that is part of the epithelium of crista of ampulla of semicircular duct of membranous labyrinth." [GOC:tfm]
xref: FMA:263200
is_a: CL:0002069 ! type II vestibular sensory cell
is_a: CL:3000004 ! peripheral sensory neuron
intersection_of: CL:0002069 ! type II vestibular sensory cell
intersection_of: part_of UBERON:0006935 ! crista ampullaris neuroepithelium
relationship: part_of UBERON:0006935 ! crista ampullaris neuroepithelium
[Term]
id: CL:1000391
name: melanocyte of eyelid
def: "A melanocyte that is part of the eyelid." [GOC:tfm]
synonym: "eyelid melanocyte" EXACT [FMA:59175]
synonym: "sebaceous gland of wolff" EXACT [FMA:59175]
xref: FMA:59175
is_a: CL:0000148 {is_inferred="true"} ! melanocyte
intersection_of: CL:0000148 ! melanocyte
intersection_of: part_of UBERON:0001711 ! eyelid
relationship: part_of UBERON:0001711 ! eyelid
[Term]
id: CL:1000397
name: endothelial cell of venous sinus of red pulp of spleen
def: "An endothelial cell that is part of the venous sinus of red pulp of spleen." [GOC:tfm]
comment: todo - add logical definition to UBERON:0009967
xref: FMA:62817
is_a: CL:0002651 ! endothelial cell of venous sinus of spleen
is_a: CL:2000053 ! splenic endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0009967 ! spleen venous sinus
relationship: part_of UBERON:0009967 ! spleen venous sinus
[Term]
id: CL:1000398
name: endothelial cell of hepatic sinusoid
def: "An endothelial cell that is part of the hepatic sinusoid. These cells possess flattened areas containing perforations about 0.1 micrometers in diameter, known as fenestrae. The fenestrae are arranged in groups known as sieve plates." [GOC:tfm, PMID:3926620]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "endotheliocyte of hepatic sinusoid" EXACT [FMA:62911]
synonym: "liver sinusoidal endothelial cell" EXACT [PMID:30348985]
synonym: "LSEC" EXACT [PMID:30348985]
xref: BTO:000125
xref: FMA:62911
is_a: CL:0000666 ! fenestrated endothelial cell
is_a: CL:0002262 ! endothelial cell of sinusoid
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0001281 ! hepatic sinusoid
relationship: part_of UBERON:0001281 ! hepatic sinusoid
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000398" xsd:string {name="endothelial cell of hepatic sinusoid on CELLxGENE CellGuide"}
[Term]
id: CL:1000405
name: epithelial cell of appendix
def: "An epithelial cell that is part of the appendix." [GOC:tfm]
synonym: "columnar epitheliocyte of appendix" EXACT [FMA:63602]
synonym: "epithelial cell of vermiform appendix" EXACT [FMA:63602]
xref: FMA:63602
is_a: CL:0002253 ! epithelial cell of large intestine
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0009697 ! epithelium of appendix
relationship: part_of UBERON:0009697 ! epithelium of appendix
[Term]
id: CL:1000409
name: myocyte of sinoatrial node
def: "A muscle cell that is part of the sinoatrial node." [FMA:67102, GOC:tfm]
subset: cellxgene_subset
synonym: "SA nodal myocyte" EXACT [FMA:67102]
synonym: "SA node cardiac muscle cell" EXACT [GOC:pr]
synonym: "sinoatrial node cell" EXACT [GOC:pr]
synonym: "sinoatrial node myocyte" EXACT []
synonym: "sinuatrial node myocyte" EXACT [FMA:67102]
xref: FMA:67102
is_a: CL:0002072 ! nodal myocyte
is_a: CL:0008009 ! transversely striated visceral muscle cell
intersection_of: CL:0000187 ! muscle cell
intersection_of: part_of UBERON:0002351 ! sinoatrial node
relationship: part_of UBERON:0002351 ! sinoatrial node
[Term]
id: CL:1000410
name: myocyte of atrioventricular node
def: "A muscle cell that is part of the atrioventricular node." [FMA:67106, GOC:tfm]
synonym: "atrioventricular node cell" EXACT [GOC:pr]
synonym: "atrioventricular node myocyte" EXACT [FMA:67106]
synonym: "AV nodal myocyte" EXACT [FMA:67106]
synonym: "AV node cardiac muscle cell" EXACT [GOC:pr]
synonym: "AV node cell" EXACT [GOC:pr]
xref: FMA:67106
is_a: CL:0002072 ! nodal myocyte
is_a: CL:0008009 ! transversely striated visceral muscle cell
is_a: CL:2000022 ! cardiac septum cell
intersection_of: CL:0000187 ! muscle cell
intersection_of: part_of UBERON:0002352 ! atrioventricular node
relationship: part_of UBERON:0002352 ! atrioventricular node
[Term]
id: CL:1000411
name: endothelial cell of Peyer's patch
def: "An endothelial cell that is part of the small intestine Peyer's patch." [GOC:tfm]
xref: FMA:67757
is_a: CL:0000131 ! gut endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0003454 ! small intestine Peyer's patch
relationship: part_of UBERON:0003454 ! small intestine Peyer's patch
[Term]
id: CL:1000412
name: endothelial cell of arteriole
def: "An endothelial cell that is part of the arteriole." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
xref: FMA:67760
xref: KUPO:0001097
is_a: CL:0000071 {is_inferred="true"} ! blood vessel endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0001980 ! arteriole
relationship: part_of UBERON:0001980 ! arteriole
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1000413
name: endothelial cell of artery
def: "A blood vessel endothelial cell that is part of an arterial endothelium." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "arterial endothelial cell" EXACT []
xref: BTO:0004758
xref: FMA:67761
xref: KUPO:0001095
is_a: CL:0000071 ! blood vessel endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0001637 ! artery
relationship: part_of UBERON:0001637 ! artery
relationship: part_of UBERON:0001917 ! endothelium of artery
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000413" xsd:string {name="endothelial cell of artery on CELLxGENE CellGuide"}
[Term]
id: CL:1000414
name: endothelial cell of venule
def: "An endothelial cell that is part of the venule." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
xref: FMA:67762
is_a: CL:0000071 ! blood vessel endothelial cell
intersection_of: CL:0002139 ! endothelial cell of vascular tree
intersection_of: part_of UBERON:0001979 ! venule
relationship: part_of UBERON:0001979 ! venule
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1000415
name: epithelial cell of gallbladder
def: "An epithelial cell that is part of the gallbladder." [GOC:tfm]
xref: FMA:67780
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0002110 ! gallbladder
relationship: part_of UBERON:0002110 ! gallbladder
[Term]
id: CL:1000417
name: myoepithelial cell of sweat gland
def: "A myoepithelial cell that is part of the sweat gland." [GOC:tfm]
subset: human_reference_atlas
xref: FMA:67801
is_a: CL:0000185 {is_inferred="true"} ! myoepithelial cell
is_a: CL:1000448 ! epithelial cell of sweat gland
intersection_of: CL:0000185 ! myoepithelial cell
intersection_of: part_of UBERON:0001820 ! sweat gland
relationship: part_of UBERON:0001820 ! sweat gland
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1000418
name: myoepithelial cell of lactiferous alveolus
def: "A myoepithelial cell that is part of the mammary gland alveolus." [GOC:tfm]
synonym: "basal cell of alveolus of lactiferous gland" EXACT [FMA:67802]
synonym: "myoepithelial cell of mammary alveolus" EXACT [FMA:67802]
xref: FMA:67802
is_a: CL:0002324 ! basal-myoepithelial cell of mammary gland
intersection_of: CL:0000185 ! myoepithelial cell
intersection_of: part_of UBERON:0003214 ! mammary gland alveolus
relationship: part_of UBERON:0003214 ! mammary gland alveolus
[Term]
id: CL:1000419
name: myoepithelial cell of lactiferous duct
def: "A myoepithelial cell that is part of the lactiferous duct." [GOC:tfm]
xref: FMA:67803
is_a: CL:0000068 ! duct epithelial cell
is_a: CL:0002324 ! basal-myoepithelial cell of mammary gland
intersection_of: CL:0000185 ! myoepithelial cell
intersection_of: part_of UBERON:0001765 ! mammary duct
relationship: part_of UBERON:0001765 ! mammary duct
[Term]
id: CL:1000424
name: chromaffin cell of paraaortic body
def: "A chromaffin cell that is part of the paraaortic body." [GOC:tfm]
synonym: "chromaffin cell of para-aortic body" EXACT [FMA:69328]
xref: FMA:69328
is_a: CL:1000425 ! chromaffin cell of paraganglion
intersection_of: CL:0000166 ! chromaffin cell
intersection_of: part_of UBERON:0001237 ! paraaortic body
relationship: part_of UBERON:0001237 ! paraaortic body
[Term]
id: CL:1000425
name: chromaffin cell of paraganglion
def: "A chromaffin cell that is part of the paraganglion." [GOC:tfm]
xref: FMA:69335
is_a: CL:0000166 {is_inferred="true"} ! chromaffin cell
intersection_of: CL:0000166 ! chromaffin cell
intersection_of: part_of UBERON:0012279 ! chromaffin paraganglion
relationship: part_of UBERON:0012279 ! chromaffin paraganglion
[Term]
id: CL:1000426
name: chromaffin cell of adrenal gland
def: "A chromaffin cell that is part of the adrenal gland." [GOC:tfm]
synonym: "adrenal chromaffin cell" EXACT [GO:0061104]
xref: FMA:69794
is_a: CL:0000150 ! glandular secretory epithelial cell
is_a: CL:0000166 {is_inferred="true"} ! chromaffin cell
intersection_of: CL:0000166 ! chromaffin cell
intersection_of: part_of UBERON:0002369 ! adrenal gland
relationship: part_of UBERON:0002369 ! adrenal gland
[Term]
id: CL:1000427
name: adrenal cortex chromaffin cell
def: "A chromaffin cell that is part of the adrenal cortex." [GOC:tfm]
comment: Not clear this cell type exists. Can't call it a cortical adrenal cell because of different germ layer origin.
synonym: "chromaffin cell of adrenal cortex" EXACT []
xref: FMA:69795
is_a: CL:1000426 ! chromaffin cell of adrenal gland
is_a: CL:1001601 ! adrenal gland glandular cell
intersection_of: CL:0000166 ! chromaffin cell
intersection_of: part_of UBERON:0001235 ! adrenal cortex
relationship: part_of UBERON:0001235 ! adrenal cortex
[Term]
id: CL:1000428
name: stem cell of epidermis
def: "A somatic stem cell that is part of the epidermis." [GOC:tfm]
subset: cellxgene_subset
synonym: "epidermal stem cell" EXACT [FMA:70541]
xref: FMA:70541
xref: ZFA:0007122 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000723 {is_inferred="true"} ! somatic stem cell
intersection_of: CL:0000723 ! somatic stem cell
intersection_of: part_of UBERON:0001003 ! skin epidermis
relationship: part_of UBERON:0001003 ! skin epidermis
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000428" xsd:string {name="stem cell of epidermis on CELLxGENE CellGuide"}
[Term]
id: CL:1000432
name: conjunctival epithelial cell
def: "An epithelial cell that is part of the conjunctiva." [GOC:tfm]
subset: cellxgene_subset
subset: eye_upper_slim
synonym: "epithelial cell of conjunctiva" EXACT [FMA:70552]
xref: FMA:70552
is_a: CL:0000066 {is_inferred="true"} ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001811 ! conjunctiva
relationship: part_of UBERON:0001811 ! conjunctiva
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000432" xsd:string {name="conjunctival epithelial cell on CELLxGENE CellGuide"}
[Term]
id: CL:1000433
name: epithelial cell of lacrimal canaliculus
def: "An epithelial cell that is part of the lacrimal canaliculus." [GOC:tfm]
xref: FMA:70553
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001770 ! lacrimal canaliculus
relationship: part_of UBERON:0001770 ! lacrimal canaliculus
[Term]
id: CL:1000434
name: epithelial cell of external acoustic meatus
def: "An epithelial cell that is part of the external acoustic meatus." [GOC:tfm]
xref: FMA:70555
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001352 ! external acoustic meatus
relationship: part_of UBERON:0001352 ! external acoustic meatus
[Term]
id: CL:1000435
name: epithelial cell of lacrimal drainage system
def: "An epithelial cell that is part of the lacrimal drainage system." [GOC:tfm, PMID:22594785]
synonym: "epithelial cell of lacrimal duct" RELATED []
xref: FMA:70559
is_a: CL:0000072 {is_inferred="true"} ! non-branched duct epithelial cell
intersection_of: CL:0000068 ! duct epithelial cell
intersection_of: part_of UBERON:0001850 ! lacrimal drainage system
relationship: part_of UBERON:0001850 ! lacrimal drainage system
[Term]
id: CL:1000436
name: epithelial cell of lacrimal sac
def: "An epithelial cell that is part of the lacrimal sac." [GOC:tfm]
xref: FMA:70560
is_a: CL:1000437 ! epithelial cell of nasolacrimal duct
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001351 ! lacrimal sac
relationship: part_of UBERON:0001351 ! lacrimal sac
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000436" xsd:string {name="epithelial cell of lacrimal sac on CELLxGENE CellGuide"}
[Term]
id: CL:1000437
name: epithelial cell of nasolacrimal duct
def: "An epithelial cell that is part of the nasolacrimal duct." [GOC:tfm]
xref: FMA:70561
is_a: CL:1000435 ! epithelial cell of lacrimal drainage system
intersection_of: CL:0000072 ! non-branched duct epithelial cell
intersection_of: part_of UBERON:0002392 ! nasolacrimal duct
relationship: part_of UBERON:0002392 ! nasolacrimal duct
[Term]
id: CL:1000442
name: urothelial cell of trigone of urinary bladder
def: "An urothelial cell that is part of the trigone of urinary bladder." [GOC:tfm]
synonym: "epithelial cell of vesical trigone" EXACT [FMA:70598]
xref: FMA:70598
is_a: CL:1001428 ! bladder urothelial cell
relationship: part_of UBERON:0001257 ! trigone of urinary bladder
[Term]
id: CL:1000443
name: ciliary muscle cell
def: "A smooth muscle cell that is part of the ciliary body." [GOC:tfm]
subset: cellxgene_subset
subset: eye_upper_slim
synonym: "smooth muscle cell of ciliary body" EXACT [FMA:70610]
xref: FMA:70610
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0001775 ! ciliary body
relationship: part_of UBERON:0001775 ! ciliary body
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000443" xsd:string {name="ciliary muscle cell on CELLxGENE CellGuide"}
[Term]
id: CL:1000444
name: mesothelial cell of anterior chamber of eye
def: "A mesothelial cell that is part of the anterior chamber of eyeball." [GOC:tfm]
xref: FMA:70615
is_a: CL:0000077 ! mesothelial cell
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0001766 ! anterior chamber of eyeball
relationship: part_of UBERON:0001766 ! anterior chamber of eyeball
[Term]
id: CL:1000445
name: myoepithelial cell of dilator pupillae
def: "A myoepithelial cell that is part of the dilatator pupillae." [GOC:tfm]
xref: FMA:70619
is_a: CL:0000185 {is_inferred="true"} ! myoepithelial cell
intersection_of: CL:0000185 ! myoepithelial cell
intersection_of: part_of UBERON:0001608 ! dilatator pupillae
relationship: part_of UBERON:0001608 ! dilatator pupillae
[Term]
id: CL:1000447
name: epithelial cell of stratum germinativum of esophagus
def: "A basal cell that is part of the epithelium of esophagus." [GOC:tfm]
subset: cellxgene_subset
synonym: "basal cell of esophageal epithelium" EXACT [FMA:70731]
xref: FMA:70731
is_a: CL:0000646 {is_inferred="true"} ! basal cell
intersection_of: CL:0000646 ! basal cell
intersection_of: part_of UBERON:0001976 ! epithelium of esophagus
relationship: part_of UBERON:0001976 ! epithelium of esophagus
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000447" xsd:string {name="epithelial cell of stratum germinativum of esophagus on CELLxGENE CellGuide"}
[Term]
id: CL:1000448
name: epithelial cell of sweat gland
def: "An epithelial cell that is part of the sweat gland." [GOC:tfm]
subset: cellxgene_subset
xref: FMA:70952
is_a: CL:0000362 ! epidermal cell
is_a: CL:0002308 ! epithelial cell of skin gland
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001820 ! sweat gland
relationship: part_of UBERON:0001820 ! sweat gland
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000448" xsd:string {name="epithelial cell of sweat gland on CELLxGENE CellGuide"}
[Term]
id: CL:1000449
name: epithelial cell of nephron
def: "An epithelial cell that is part of the nephron." [GOC:tfm]
subset: cellxgene_subset
xref: FMA:70965
is_a: CL:0002518 ! kidney epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001285 ! nephron
relationship: part_of UBERON:0001285 ! nephron
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000449" xsd:string {name="epithelial cell of nephron on CELLxGENE CellGuide"}
[Term]
id: CL:1000450
name: epithelial cell of glomerular capsule
def: "An epithelial cell that is part of the glomerular capsule." [GOC:tfm]
subset: cellxgene_subset
subset: kidney_upper_slim
synonym: "Bowmans capsule epithelial cell" EXACT []
synonym: "epithelial cell of Bowman's capsule" EXACT [FMA:70966]
xref: FMA:70966
xref: KUPO:0001034
is_a: CL:1000510 ! kidney glomerular epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001230 ! glomerular capsule
relationship: part_of UBERON:0001230 ! glomerular capsule
[Term]
id: CL:1000452
name: parietal epithelial cell
def: "An epithelial cell that is part of the glomerular parietal epithelium." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "epithelial cell of parietal layer of glomerular capsule" EXACT [FMA:70968]
xref: FMA:70968
xref: KUPO:0001035
is_a: CL:1000450 ! epithelial cell of glomerular capsule
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0005750 ! glomerular parietal epithelium
relationship: part_of UBERON:0005750 ! glomerular parietal epithelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1000453
name: epithelial cell of intermediate tubule
def: "An epithelial cell that is part of the intermediate tubule." [GOC:tfm]
xref: FMA:70980
is_a: CL:1000909 ! kidney loop of Henle epithelial cell
intersection_of: CL:1000494 ! nephron tubule epithelial cell
intersection_of: part_of UBERON:0004136 ! intermediate tubule
relationship: part_of UBERON:0004136 ! intermediate tubule
[Term]
id: CL:1000454
name: kidney collecting duct epithelial cell
def: "An epithelial cell that is part of the collecting duct of renal tubule." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
subset: kidney_upper_slim
synonym: "epithelial cell of renal collecting tubule" EXACT [FMA:70982]
xref: FMA:70982
xref: KUPO:0001059
is_a: CL:0000072 {is_inferred="true"} ! non-branched duct epithelial cell
is_a: CL:1000449 ! epithelial cell of nephron
is_a: CL:1001225 {is_inferred="true"} ! kidney collecting duct cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001232 ! collecting duct of renal tubule
relationship: part_of UBERON:0001232 ! collecting duct of renal tubule
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000454" xsd:string {name="kidney collecting duct epithelial cell on CELLxGENE CellGuide"}
[Term]
id: CL:1000456
name: mesothelial cell of parietal peritoneum
def: "A mesothelial cell that is part of the parietal peritoneum." [GOC:tfm]
xref: FMA:72142
is_a: CL:1000490 ! mesothelial cell of peritoneum
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0001366 ! parietal peritoneum
relationship: part_of UBERON:0001366 ! parietal peritoneum
[Term]
id: CL:1000457
name: mesothelial cell of visceral peritoneum
def: "A mesothelial cell that is part of the visceral peritoneum." [GOC:tfm]
subset: human_reference_atlas
xref: FMA:72143
is_a: CL:1000490 ! mesothelial cell of peritoneum
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0001178 ! visceral peritoneum
relationship: part_of UBERON:0001178 ! visceral peritoneum
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1000458
name: melanocyte of skin
def: "A melanocyte that is part of the skin of body." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "skin melanocyte" EXACT [FMA:72144]
xref: CALOHA:TS-2374
xref: FMA:72144
is_a: CL:0000148 {is_inferred="true"} ! melanocyte
intersection_of: CL:0000148 ! melanocyte
intersection_of: part_of UBERON:0002097 ! skin of body
relationship: part_of UBERON:0002097 ! skin of body
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000458" xsd:string {name="melanocyte of skin on CELLxGENE CellGuide"}
[Term]
id: CL:1000465
name: chromaffin cell of ovary
def: "A chromaffin cell that is part of the ovary." [GOC:tfm]
xref: FMA:74319
is_a: CL:0000166 {is_inferred="true"} ! chromaffin cell
intersection_of: CL:0000166 ! chromaffin cell
intersection_of: part_of UBERON:0000992 ! ovary
relationship: part_of UBERON:0000992 ! ovary
[Term]
id: CL:1000466
name: chromaffin cell of right ovary
def: "A chromaffin cell that is part of the right ovary." [GOC:tfm]
xref: FMA:74320
is_a: CL:1000465 ! chromaffin cell of ovary
intersection_of: CL:0000166 ! chromaffin cell
intersection_of: part_of UBERON:0002118 ! right ovary
relationship: part_of UBERON:0002118 ! right ovary
[Term]
id: CL:1000467
name: chromaffin cell of left ovary
def: "A chromaffin cell that is part of the left ovary." [GOC:tfm]
xref: FMA:74321
is_a: CL:1000465 ! chromaffin cell of ovary
intersection_of: CL:0000166 ! chromaffin cell
intersection_of: part_of UBERON:0002119 ! left ovary
relationship: part_of UBERON:0002119 ! left ovary
[Term]
id: CL:1000478
name: transitional myocyte of sinoatrial node
def: "A transitional myocyte that is part of the sinoatrial node." [GOC:tfm]
synonym: "transitinal myocyte of sinuatrial node" EXACT []
xref: FMA:83384
is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte
is_a: CL:1000409 ! myocyte of sinoatrial node
intersection_of: CL:0002073 ! transitional myocyte
intersection_of: part_of UBERON:0002351 ! sinoatrial node
relationship: part_of UBERON:0002351 ! sinoatrial node
[Term]
id: CL:1000479
name: Purkinje myocyte of atrioventricular node
def: "A Purkinje myocyte that is part of the atrioventricular node." [GOC:tfm]
xref: FMA:83386
is_a: CL:0002068 {is_inferred="true"} ! Purkinje myocyte
is_a: CL:1000410 ! myocyte of atrioventricular node
intersection_of: CL:0002068 ! Purkinje myocyte
intersection_of: part_of UBERON:0002352 ! atrioventricular node
relationship: part_of UBERON:0002352 ! atrioventricular node
[Term]
id: CL:1000480
name: transitional myocyte of internodal tract
def: "A transitional myocyte that is part of the internodal tract." [GOC:tfm]
xref: FMA:83387
is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte
is_a: CL:0002096 ! internodal tract myocyte
intersection_of: CL:0002073 ! transitional myocyte
intersection_of: part_of UBERON:0009966 ! internodal tract
relationship: part_of UBERON:0009966 ! internodal tract
[Term]
id: CL:1000481
name: transitional myocyte of atrioventricular bundle
def: "A transitional myocyte that is part of the atrioventricular bundle." [GOC:tfm]
xref: FMA:83388
is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte
is_a: CL:0008009 ! transversely striated visceral muscle cell
is_a: CL:0010005 ! atrioventricular bundle cell
is_a: CL:2000046 ! ventricular cardiac muscle cell
intersection_of: CL:0002073 ! transitional myocyte
intersection_of: part_of UBERON:0002353 ! bundle of His
relationship: part_of UBERON:0002353 ! bundle of His
[Term]
id: CL:1000482
name: myocardial endocrine cell of interventricular septum
def: "A myocardial endocrine cell that is part of the interventricular septum." [GOC:tfm]
xref: FMA:83390
is_a: CL:0002074 {is_inferred="true"} ! myocardial endocrine cell
is_a: CL:2000022 ! cardiac septum cell
intersection_of: CL:0002074 ! myocardial endocrine cell
intersection_of: part_of UBERON:0002094 ! interventricular septum
relationship: part_of UBERON:0002094 ! interventricular septum
[Term]
id: CL:1000483
name: Purkinje myocyte of internodal tract
def: "A Purkinje myocyte that is part of the internodal tract." [GOC:tfm]
xref: FMA:83392
is_a: CL:0002068 {is_inferred="true"} ! Purkinje myocyte
is_a: CL:0002096 ! internodal tract myocyte
intersection_of: CL:0002068 ! Purkinje myocyte
intersection_of: part_of UBERON:0009966 ! internodal tract
relationship: part_of UBERON:0009966 ! internodal tract
[Term]
id: CL:1000484
name: Purkinje myocyte of atrioventricular bundle
def: "A Purkinje myocyte that is part of the atrioventricular bundle." [GOC:tfm]
xref: FMA:83393
is_a: CL:0002068 {is_inferred="true"} ! Purkinje myocyte
is_a: CL:0008009 ! transversely striated visceral muscle cell
is_a: CL:0010005 ! atrioventricular bundle cell
is_a: CL:2000046 ! ventricular cardiac muscle cell
intersection_of: CL:0002068 ! Purkinje myocyte
intersection_of: part_of UBERON:0002353 ! bundle of His
relationship: part_of UBERON:0002353 ! bundle of His
[Term]
id: CL:1000486
name: basal cell of urothelium
def: "A basal cell that is part of the urothelium. Compared to other urothelial cell types, a basal cell of the urothelium is positioned along the basement membrane, is the most undifferentiated and serves a progenitor role." [doi:10.1038/s41385-022-00565-0, GOC:tfm]
comment: It has been noted in at least some mammalian species that the urothelial basal cell type is distinguished by expression of high levels of cytokeratin-5 (CK5), p63 and the signalling molecule Sonic hedgehog (Shh). Similar to intermediate cells, the urothelial basal cell type expresses CK17 but is negative for uroplakins (UPK) and CK20. Urothelial basal cells have also been noted to be smaller in diameter than urothelial intermediate cells. {xref="doi:10.1038/s41385-022-00565-0"}
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "urothelial basal cell" EXACT [doi:10.1007/978-3-030-14366-4_8, doi:10.1111/cpr.13170]
xref: FMA:84150
is_a: CL:0000646 {is_inferred="true"} ! basal cell
is_a: CL:0000731 ! urothelial cell
intersection_of: CL:0000646 ! basal cell
intersection_of: part_of UBERON:0000365 ! urothelium
relationship: part_of UBERON:0000365 ! urothelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1000487
name: smooth muscle cell of prostate
def: "A smooth muscle cell that is part of the prostate gland." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "smooth muscle fiber of prostate" EXACT [FMA:84583]
xref: FMA:84583
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0002367 ! prostate gland
relationship: part_of UBERON:0002367 ! prostate gland
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000487" xsd:string {name="smooth muscle cell of prostate on CELLxGENE CellGuide"}
[Term]
id: CL:1000488
name: cholangiocyte
def: "An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts." [GOC:tfm, PMID:16550043, PMID:18356246]
subset: cellxgene_subset
synonym: "epithelial cell of bile duct" EXACT []
xref: FMA:86481
xref: ZFA:0009397 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000069 {is_inferred="true"} ! branched duct epithelial cell
intersection_of: CL:0000069 ! branched duct epithelial cell
intersection_of: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity
intersection_of: part_of UBERON:0002394 ! bile duct
relationship: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity
relationship: develops_from CL:0005026 ! hepatoblast
relationship: part_of UBERON:0002394 ! bile duct
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000488" xsd:string {name="cholangiocyte on CELLxGENE CellGuide"}
[Term]
id: CL:1000489
name: reticular cell of splenic cord
def: "A reticular cell that is part of the splenic cord." [GOC:tfm]
subset: human_reference_atlas
xref: FMA:86497
is_a: CL:0000432 {is_inferred="true"} ! reticular cell
is_a: CL:2000051 ! splenic fibroblast
intersection_of: CL:0000432 ! reticular cell
intersection_of: part_of UBERON:0001266 ! splenic cord
relationship: part_of UBERON:0001266 ! splenic cord
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1000490
name: mesothelial cell of peritoneum
def: "A mesothelial cell that is part of the peritoneum." [GOC:tfm]
synonym: "peritoneal mesothelial cell" EXACT [FMA:86736]
xref: FMA:86736
is_a: CL:0000077 ! mesothelial cell
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0002358 ! peritoneum
relationship: part_of UBERON:0002358 ! peritoneum
[Term]
id: CL:1000491
name: mesothelial cell of pleura
def: "A mesothelial cell that is part of the pleura." [GOC:tfm]
subset: cellxgene_subset
synonym: "pleural mesothelial cell" EXACT [FMA:86737]
xref: FMA:86737
is_a: CL:0000077 ! mesothelial cell
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0000977 ! pleura
relationship: part_of UBERON:0000977 ! pleura
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000491" xsd:string {name="mesothelial cell of pleura on CELLxGENE CellGuide"}
[Term]
id: CL:1000492
name: mesothelial cell of parietal pleura
def: "A mesothelial cell that is part of the parietal pleura." [GOC:tfm]
xref: FMA:86738
is_a: CL:1000491 ! mesothelial cell of pleura
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0002400 ! parietal pleura
relationship: part_of UBERON:0002400 ! parietal pleura
[Term]
id: CL:1000493
name: mesothelial cell of visceral pleura
def: "A mesothelial cell that is part of the visceral pleura." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
xref: FMA:86739
is_a: CL:1000491 ! mesothelial cell of pleura
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0002401 ! visceral pleura
relationship: part_of UBERON:0002401 ! visceral pleura
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000493" xsd:string {name="mesothelial cell of visceral pleura on CELLxGENE CellGuide"}
[Term]
id: CL:1000494
name: nephron tubule epithelial cell
def: "An epithelial cell that is part of a nephron tubule." [GOC:tfm]
comment: This needs to be further defined as a juxtamedullary nephron. Will request the juxtamedullary nephron tubule class from UBERON.
subset: cellxgene_subset
synonym: "kidney tubule epithelial cell" EXACT []
xref: FMA:86785
xref: KUPO:0001022
is_a: CL:1000449 ! epithelial cell of nephron
is_a: CL:1000507 ! kidney tubule cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0004810 ! nephron tubule epithelium
relationship: part_of UBERON:0004810 ! nephron tubule epithelium
[Term]
id: CL:1000495
name: small intestine goblet cell
def: "A goblet cell that is part of the small intestine." [GOC:tfm]
subset: cellxgene_subset
synonym: "goblet cell of epithelium of small intestine" EXACT []
synonym: "goblet cell of small intestine" EXACT []
synonym: "small intestinal goblet cell" EXACT [FMA:86929]
xref: FMA:86929
is_a: CL:0019031 ! intestine goblet cell
is_a: CL:1001598 ! small intestine secretory cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0001902 ! epithelium of small intestine
relationship: part_of UBERON:0001902 ! epithelium of small intestine
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000495" xsd:string {name="small intestine goblet cell on CELLxGENE CellGuide"}
[Term]
id: CL:1000497
name: kidney cell
def: "A cell that is part of a kidney." []
subset: cellxgene_subset
xref: KUPO:0001010
xref: ZFA:0009389 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0002113 ! kidney
relationship: part_of UBERON:0002113 ! kidney
[Term]
id: CL:1000500
name: kidney interstitial cell
def: "A cell that is part of kidney interstitium." []
subset: cellxgene_subset
subset: kidney_upper_slim
xref: KUPO:0001013
xref: ZFA:0009390 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:1000497 ! kidney cell
is_a: CL:4030031 ! interstitial cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0005215 ! kidney interstitium
relationship: part_of UBERON:0005215 ! kidney interstitium
[Term]
id: CL:1000504
name: kidney medulla cell
def: "A cell that is part of a renal medulla." [PMID:22343825]
xref: KUPO:0001017
xref: ZFA:0009391 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"}
is_a: CL:1000497 ! kidney cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0000362 ! renal medulla
relationship: part_of UBERON:0000362 ! renal medulla
[Term]
id: CL:1000505
name: kidney pelvis cell
def: "A cell that is part of a renal pelvis." []
subset: kidney_upper_slim
xref: KUPO:0001018
is_a: CL:1000497 ! kidney cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0001224 ! renal pelvis
relationship: part_of UBERON:0001224 ! renal pelvis
[Term]
id: CL:1000507
name: kidney tubule cell
def: "A cell that is part of a nephron tubule." []
subset: cellxgene_subset
subset: kidney_upper_slim
xref: KUPO:0001020
is_a: CL:1000497 ! kidney cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0001231 ! nephron tubule
relationship: part_of UBERON:0001231 ! nephron tubule
[Term]
id: CL:1000510
name: kidney glomerular epithelial cell
def: "Any kidney epithelial cell that is part of some glomerular epithelium." [FBC:Autogenerated]
subset: cellxgene_subset
xref: KUPO:0001023
is_a: CL:1000746 ! glomerular cell
intersection_of: CL:0002518 ! kidney epithelial cell
intersection_of: part_of UBERON:0004188 ! glomerular epithelium
relationship: part_of UBERON:0004188 ! glomerular epithelium
[Term]
id: CL:1000546
name: kidney medulla collecting duct epithelial cell
def: "An epithelial cell that is part of a renal medulla collecting duct." []
subset: kidney_upper_slim
xref: KUPO:0001060
is_a: CL:1000454 ! kidney collecting duct epithelial cell
is_a: CL:1000504 ! kidney medulla cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0005185 ! renal medulla collecting duct
relationship: part_of UBERON:0005185 ! renal medulla collecting duct
[Term]
id: CL:1000547
name: kidney inner medulla collecting duct epithelial cell
def: "An epithelial cell that is part of some inner medullary collecting duct." []
subset: cellxgene_subset
xref: KUPO:0001061
is_a: CL:1000546 ! kidney medulla collecting duct epithelial cell
is_a: CL:1000617 ! kidney inner medulla cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0004205 ! inner medullary collecting duct
relationship: part_of UBERON:0004205 ! inner medullary collecting duct
[Term]
id: CL:1000548
name: kidney outer medulla collecting duct epithelial cell
def: "An epithelial cell that is part of an outer medullary collecting duct." []
xref: KUPO:0001062
is_a: CL:1000546 ! kidney medulla collecting duct epithelial cell
is_a: CL:1000616 ! kidney outer medulla cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0004204 ! outer medullary collecting duct
relationship: part_of UBERON:0004204 ! outer medullary collecting duct
[Term]
id: CL:1000549
name: kidney cortex collecting duct epithelial cell
def: "An epithelial cell that is part of a cortical collecting duct." []
subset: cellxgene_subset
xref: KUPO:0001063
is_a: CL:0002584 ! renal cortical epithelial cell
is_a: CL:1000454 ! kidney collecting duct epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0004203 ! cortical collecting duct
relationship: part_of UBERON:0004203 ! cortical collecting duct
[Term]
id: CL:1000550
name: kidney papillary duct principal epithelial cell
def: "Any kidney cell that is part of some papillary duct." [FBC:Autogenerated]
subset: kidney_upper_slim
xref: KUPO:0001064
is_a: CL:1001225 ! kidney collecting duct cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0005167 ! papillary duct
relationship: part_of UBERON:0005167 ! papillary duct
[Term]
id: CL:1000596
name: inner renal cortex cell
def: "Any kidney cell that is part of some juxtamedullary cortex." [FBC:Autogenerated]
xref: KUPO:0001111
is_a: CL:0002681 ! kidney cortical cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0005271 ! juxtamedullary cortex
relationship: part_of UBERON:0005271 ! juxtamedullary cortex
[Term]
id: CL:1000597
name: papillary tips cell
def: "A cell that is part of a tip of a renal papilla." []
subset: cellxgene_subset
subset: human_reference_atlas
xref: KUPO:0001112
is_a: CL:1000505 ! kidney pelvis cell
is_a: CL:1000617 ! kidney inner medulla cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0009095 ! tip of renal papilla
relationship: part_of UBERON:0009095 ! tip of renal papilla
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1000600
name: lower urinary tract cell
def: "Any cell that is part of some lower urinary tract." [FBC:Autogenerated]
xref: KUPO:0001115
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0001556 ! lower urinary tract
relationship: part_of UBERON:0001556 ! lower urinary tract
[Term]
id: CL:1000601
name: ureteral cell
def: "Any cell that is part of some ureter." [FBC:Autogenerated]
xref: KUPO:0001116
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0000056 ! ureter
relationship: part_of UBERON:0000056 ! ureter
[Term]
id: CL:1000606
name: kidney nerve cell
def: "Any neuron that has its soma located in some kidney." [FBC:Autogenerated]
xref: KUPO:0001015
is_a: CL:1000500 ! kidney interstitial cell
is_a: CL:2000032 ! peripheral nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0002113 ! has soma location kidney
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: RO:0002100 UBERON:0002113 ! has soma location kidney
[Term]
id: CL:1000612
name: kidney corpuscule cell
def: "Any renal cortical epithelial cell that is part of some renal corpuscle." [FBC:Autogenerated]
subset: kidney_upper_slim
xref: KUPO:0001021
is_a: CL:0002584 ! renal cortical epithelial cell
is_a: CL:1000449 ! epithelial cell of nephron
intersection_of: CL:0002584 ! renal cortical epithelial cell
intersection_of: part_of UBERON:0001229 ! renal corpuscle
relationship: part_of UBERON:0001229 ! renal corpuscle
[Term]
id: CL:1000615
name: kidney cortex tubule cell
def: "Any kidney tubule cell that is part of some renal cortex tubule." [FBC:Autogenerated]
subset: cellxgene_subset
xref: KUPO:0001024
is_a: CL:0002584 ! renal cortical epithelial cell
is_a: CL:1000449 ! epithelial cell of nephron
is_a: CL:1000507 {is_inferred="true"} ! kidney tubule cell
intersection_of: CL:1000507 ! kidney tubule cell
intersection_of: part_of UBERON:0006853 ! renal cortex tubule
relationship: part_of UBERON:0006853 ! renal cortex tubule
[Term]
id: CL:1000616
name: kidney outer medulla cell
def: "Any kidney medulla cell that is part of some outer medulla of kidney." [FBC:Autogenerated]
xref: KUPO:0001025
is_a: CL:1000504 {is_inferred="true"} ! kidney medulla cell
intersection_of: CL:1000504 ! kidney medulla cell
intersection_of: part_of UBERON:0001293 ! outer medulla of kidney
relationship: part_of UBERON:0001293 ! outer medulla of kidney
[Term]
id: CL:1000617
name: kidney inner medulla cell
def: "Any kidney medulla cell that is part of some inner medulla of kidney." [FBC:Autogenerated]
xref: KUPO:0001026
is_a: CL:1000504 {is_inferred="true"} ! kidney medulla cell
intersection_of: CL:1000504 ! kidney medulla cell
intersection_of: part_of UBERON:0001294 ! inner medulla of kidney
relationship: part_of UBERON:0001294 ! inner medulla of kidney
[Term]
id: CL:1000618
name: juxtaglomerular complex cell
def: "Any kidney cortical cell that is part of some juxtaglomerular apparatus." [FBC:Autogenerated]
subset: kidney_upper_slim
synonym: "juxtaglomerulus cell" EXACT [GO:0072052]
xref: KUPO:0001028
is_a: CL:0002681 {is_inferred="true"} ! kidney cortical cell
intersection_of: CL:0002681 ! kidney cortical cell
intersection_of: part_of UBERON:0002303 ! juxtaglomerular apparatus
relationship: part_of UBERON:0002303 ! juxtaglomerular apparatus
[Term]
id: CL:1000681
name: kidney cortex interstitial cell
def: "A cell that is part of an interstitial compartment of a renal cortex." [PMID:18575881]
xref: KUPO:0001091
is_a: CL:0002584 ! renal cortical epithelial cell
is_a: CL:1000500 {is_inferred="true"} ! kidney interstitial cell
intersection_of: CL:1000500 ! kidney interstitial cell
intersection_of: part_of UBERON:0005270 ! renal cortex interstitium
relationship: part_of UBERON:0005270 ! renal cortex interstitium
[Term]
id: CL:1000682
name: kidney medulla interstitial cell
def: "A cell that is part of an interstitum of a renal medulla." [PMID:21359760]
xref: KUPO:0001092
is_a: CL:1000500 {is_inferred="true"} ! kidney interstitial cell
is_a: CL:1000504 {is_inferred="true"} ! kidney medulla cell
intersection_of: CL:1000500 ! kidney interstitial cell
intersection_of: part_of UBERON:0005211 ! renal medulla interstitium
relationship: part_of UBERON:0005211 ! renal medulla interstitium
[Term]
id: CL:1000692
name: kidney interstitial fibroblast
def: "A fibroblast that is part of an interstitial compartment of a kidney." [PMID:10559635]
subset: cellxgene_subset
subset: human_reference_atlas
xref: KUPO:0001102
is_a: CL:0000057 ! fibroblast
is_a: CL:1000500 ! kidney interstitial cell
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0005215 ! kidney interstitium
relationship: part_of UBERON:0005215 ! kidney interstitium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000692" xsd:string {name="kidney interstitial fibroblast on CELLxGENE CellGuide"}
[Term]
id: CL:1000702
name: kidney pelvis smooth muscle cell
def: "Any smooth muscle cell that is part of some kidney pelvis smooth muscle." [FBC:Autogenerated]
xref: KUPO:0001113
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
is_a: CL:1000505 {is_inferred="true"} ! kidney pelvis cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0004227 ! kidney pelvis smooth muscle
relationship: part_of UBERON:0004227 ! kidney pelvis smooth muscle
[Term]
id: CL:1000703
name: kidney pelvis urothelial cell
def: "Any kidney epithelial cell that is part of some kidney pelvis urothelium." [FBC:Autogenerated]
subset: cellxgene_subset
xref: KUPO:0001114
is_a: CL:0000731 ! urothelial cell
is_a: CL:0002518 {is_inferred="true"} ! kidney epithelial cell
is_a: CL:1000505 {is_inferred="true"} ! kidney pelvis cell
intersection_of: CL:0002518 ! kidney epithelial cell
intersection_of: part_of UBERON:0004788 ! kidney pelvis urothelium
relationship: part_of UBERON:0004788 ! kidney pelvis urothelium
[Term]
id: CL:1000706
name: ureter urothelial cell
def: "A urothelial cell that is part of the urothelium of ureter." [PMID:36180582]
xref: KUPO:0001117
is_a: CL:0000731 ! urothelial cell
is_a: CL:1000601 ! ureteral cell
intersection_of: CL:0000731 ! urothelial cell
intersection_of: part_of UBERON:0001254 ! urothelium of ureter
relationship: part_of UBERON:0001254 ! urothelium of ureter
[Term]
id: CL:1000708
name: ureter adventitial cell
def: "Any ureteral cell that is part of some adventitia of ureter." [FBC:Autogenerated]
subset: human_reference_atlas
xref: KUPO:0001119
is_a: CL:0000115 ! endothelial cell
is_a: CL:0002503 ! adventitial cell
is_a: CL:1000601 {is_inferred="true"} ! ureteral cell
intersection_of: CL:1000601 ! ureteral cell
intersection_of: part_of UBERON:0001252 ! adventitia of ureter
relationship: part_of UBERON:0001252 ! adventitia of ureter
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1000714
name: kidney cortex collecting duct principal cell
def: "Any renal principal cell that is part of some cortical collecting duct." [FBC:Autogenerated]
subset: human_reference_atlas
xref: KUPO:0001130
is_a: CL:1000549 {is_inferred="true"} ! kidney cortex collecting duct epithelial cell
is_a: CL:1001431 ! kidney collecting duct principal cell
intersection_of: CL:0005009 ! renal principal cell
intersection_of: part_of UBERON:0004203 ! cortical collecting duct
relationship: part_of UBERON:0004203 ! cortical collecting duct
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1000716
name: kidney outer medulla collecting duct principal cell
def: "Principal cell that is part of some outer medullary collecting duct. It is known in some mammalian species that this cell may express the epithelial sodium channel (ENaC)." [PMID:25632105]
subset: human_reference_atlas
xref: KUPO:0001132
is_a: CL:1000548 {is_inferred="true"} ! kidney outer medulla collecting duct epithelial cell
is_a: CL:1001431 ! kidney collecting duct principal cell
intersection_of: CL:0005009 ! renal principal cell
intersection_of: part_of UBERON:0004204 ! outer medullary collecting duct
relationship: part_of UBERON:0004204 ! outer medullary collecting duct
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1000718
name: kidney inner medulla collecting duct principal cell
def: "Any renal principal cell that is part of some inner medullary collecting duct." [FBC:Autogenerated]
subset: human_reference_atlas
xref: KUPO:0001134
is_a: CL:1000547 {is_inferred="true"} ! kidney inner medulla collecting duct epithelial cell
is_a: CL:1001431 ! kidney collecting duct principal cell
intersection_of: CL:0005009 ! renal principal cell
intersection_of: part_of UBERON:0004205 ! inner medullary collecting duct
relationship: part_of UBERON:0004205 ! inner medullary collecting duct
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1000721
name: kidney papillary duct principal cell
def: "Any renal principal cell that is part of some papillary duct." [FBC:Autogenerated]
xref: KUPO:0001137
is_a: CL:1000550 {is_inferred="true"} ! kidney papillary duct principal epithelial cell
is_a: CL:1001431 ! kidney collecting duct principal cell
intersection_of: CL:0005009 ! renal principal cell
intersection_of: part_of UBERON:0005167 ! papillary duct
relationship: part_of UBERON:0005167 ! papillary duct
[Term]
id: CL:1000746
name: glomerular cell
def: "Any kidney corpuscule cell that is part of some renal glomerulus." [FBC:Autogenerated]
xref: KUPO:0001036
is_a: CL:1000612 ! kidney corpuscule cell
intersection_of: CL:1000612 ! kidney corpuscule cell
intersection_of: part_of UBERON:0000074 ! renal glomerulus
relationship: part_of UBERON:0000074 ! renal glomerulus
[Term]
id: CL:1000768
name: kidney connecting tubule epithelial cell
def: "Any nephron tubule epithelial cell that is part of some renal connecting tubule." [FBC:Autogenerated]
subset: cellxgene_subset
subset: human_reference_atlas
subset: kidney_upper_slim
xref: KUPO:0001058
is_a: CL:1000494 {is_inferred="true"} ! nephron tubule epithelial cell
is_a: CL:1000615 ! kidney cortex tubule cell
intersection_of: CL:1000494 ! nephron tubule epithelial cell
intersection_of: part_of UBERON:0005097 ! renal connecting tubule
relationship: part_of UBERON:0005097 ! renal connecting tubule
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000768" xsd:string {name="kidney connecting tubule epithelial cell on CELLxGENE CellGuide"}
[Term]
id: CL:1000803
name: kidney inner medulla interstitial cell
def: "A cell that is part of an interstitial compartment of an inner renal medulla." [PMID:21359760]
xref: KUPO:0001093
is_a: CL:1000617 {is_inferred="true"} ! kidney inner medulla cell
is_a: CL:1000682 {is_inferred="true"} ! kidney medulla interstitial cell
intersection_of: CL:1000682 ! kidney medulla interstitial cell
intersection_of: part_of UBERON:0005214 ! inner renal medulla interstitium
relationship: part_of UBERON:0005214 ! inner renal medulla interstitium
[Term]
id: CL:1000804
name: kidney outer medulla interstitial cell
def: "A kidney cell that is part of an interstitial compartment of an outer renal medulla." [PMID:8694267]
xref: KUPO:0001094
is_a: CL:1000616 {is_inferred="true"} ! kidney outer medulla cell
is_a: CL:1000682 {is_inferred="true"} ! kidney medulla interstitial cell
intersection_of: CL:1000682 ! kidney medulla interstitial cell
intersection_of: part_of UBERON:0005213 ! outer renal medulla interstitium
relationship: part_of UBERON:0005213 ! outer renal medulla interstitium
[Term]
id: CL:1000838
name: kidney proximal convoluted tubule epithelial cell
def: "Any epithelial cell of proximal tubule that is part of some proximal convoluted tubule and has part some brush border." [FBC:Autogenerated]
subset: cellxgene_subset
xref: KUPO:0001045
is_a: CL:0002307 ! brush border cell of the proximal tubule
intersection_of: CL:0002306 ! epithelial cell of proximal tubule
intersection_of: has_part GO:0005903 ! brush border
intersection_of: part_of UBERON:0001287 ! proximal convoluted tubule
relationship: has_part GO:0005903 ! brush border
relationship: part_of UBERON:0001287 ! proximal convoluted tubule
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000838" xsd:string {name="kidney proximal convoluted tubule epithelial cell on CELLxGENE CellGuide"}
[Term]
id: CL:1000839
name: kidney proximal straight tubule epithelial cell
def: "Any epithelial cell of proximal tubule that is part of some proximal straight tubule." [FBC:Autogenerated]
subset: cellxgene_subset
xref: KUPO:0001046
is_a: CL:0002306 {is_inferred="true"} ! epithelial cell of proximal tubule
is_a: CL:1000616 {is_inferred="true"} ! kidney outer medulla cell
is_a: CL:1001021 ! kidney loop of Henle descending limb epithelial cell
intersection_of: CL:0002306 ! epithelial cell of proximal tubule
intersection_of: part_of UBERON:0001290 ! proximal straight tubule
relationship: part_of UBERON:0001290 ! proximal straight tubule
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000839" xsd:string {name="kidney proximal straight tubule epithelial cell on CELLxGENE CellGuide"}
[Term]
id: CL:1000849
name: kidney distal convoluted tubule epithelial cell
def: "Any epithelial cell of distal tubule that is part of some distal convoluted tubule." [FBC:Autogenerated]
subset: cellxgene_subset
subset: human_reference_atlas
subset: kidney_upper_slim
xref: KUPO:0001056
is_a: CL:0002305 {is_inferred="true"} ! epithelial cell of distal tubule
intersection_of: CL:0002305 ! epithelial cell of distal tubule
intersection_of: part_of UBERON:0001292 ! distal convoluted tubule
relationship: part_of UBERON:0001292 ! distal convoluted tubule
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000849" xsd:string {name="kidney distal convoluted tubule epithelial cell on CELLxGENE CellGuide"}
[Term]
id: CL:1000850
name: macula densa epithelial cell
def: "An epithelial cell that is part of the macula densa, characterized by a tightly packed arrangement, apically positioned nuclei, and prominent primary cilia, creating a distinctive 'dense spot' appearance under microscopy. It is involved in regulating renal blood flow, glomerular filtration rate, and renin release." [PMID:33491562, PMID:36142420, Wikipedia:Macula_densa]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "macula densa cell" EXACT [PMID:33491562]
xref: KUPO:0001057
is_a: CL:0000067 ! ciliated epithelial cell
is_a: CL:0002305 ! epithelial cell of distal tubule
is_a: CL:1000618 {is_inferred="true"} ! juxtaglomerular complex cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0002335 ! macula densa
relationship: capable_of GO:0003093 ! regulation of glomerular filtration
relationship: capable_of GO:1900133 ! regulation of renin secretion into blood stream
relationship: has_part GO:0097730 ! non-motile cilium
relationship: part_of UBERON:0002335 ! macula densa
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000850" xsd:string {name="macula densa epithelial cell on CELLxGENE CellGuide"}
[Term]
id: CL:1000854
name: kidney blood vessel cell
def: "A blood vessel cell that is part of a kidney." [PMID:34843404]
xref: KUPO:0001014
is_a: CL:1000504 {is_inferred="true"} ! kidney medulla cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0003517 ! kidney blood vessel
relationship: part_of UBERON:0003517 ! kidney blood vessel
relationship: participates_in GO:0008015 ! blood circulation
[Term]
id: CL:1000891
name: kidney arterial blood vessel cell
def: "Any kidney blood vessel cell that is part of some kidney arterial blood vessel." [FBC:Autogenerated]
subset: cellxgene_subset
subset: kidney_upper_slim
xref: KUPO:0001029
is_a: CL:1000854 {is_inferred="true"} ! kidney blood vessel cell
intersection_of: CL:1000854 ! kidney blood vessel cell
intersection_of: part_of UBERON:0003644 ! kidney arterial blood vessel
relationship: part_of UBERON:0003644 ! kidney arterial blood vessel
[Term]
id: CL:1000892
name: kidney capillary endothelial cell
def: "An endothelial cell that is part of the capillary of the kidney." []
subset: cellxgene_subset
subset: kidney_upper_slim
xref: KUPO:0001030
is_a: CL:0002144 ! capillary endothelial cell
is_a: CL:1000854 ! kidney blood vessel cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0003527 ! kidney capillary
relationship: part_of UBERON:0003527 ! kidney capillary
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000892" xsd:string {name="kidney capillary endothelial cell on CELLxGENE CellGuide"}
[Term]
id: CL:1000893
name: kidney venous blood vessel cell
def: "Any kidney blood vessel cell that is part of some renal vein." [FBC:Autogenerated]
subset: kidney_upper_slim
xref: KUPO:0001031
is_a: CL:1000854 {is_inferred="true"} ! kidney blood vessel cell
intersection_of: CL:1000854 ! kidney blood vessel cell
intersection_of: part_of UBERON:0001140 ! renal vein
relationship: part_of UBERON:0001140 ! renal vein
[Term]
id: CL:1000909
name: kidney loop of Henle epithelial cell
def: "Any nephron tubule epithelial cell that is part of some loop of Henle." [FBC:Autogenerated]
subset: cellxgene_subset
xref: KUPO:0001047
is_a: CL:1000494 {is_inferred="true"} ! nephron tubule epithelial cell
intersection_of: CL:1000494 ! nephron tubule epithelial cell
intersection_of: part_of UBERON:0001288 ! loop of Henle
relationship: part_of UBERON:0001288 ! loop of Henle
[Term]
id: CL:1000979
name: ureter smooth muscle cell
def: "Any smooth muscle cell that is part of some muscular coat of ureter." [FBC:Autogenerated]
subset: human_reference_atlas
xref: KUPO:0001118
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
is_a: CL:1000601 {is_inferred="true"} ! ureteral cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0006855 ! muscular coat of ureter
relationship: part_of UBERON:0006855 ! muscular coat of ureter
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1001005
name: glomerular capillary endothelial cell
def: "An endothelial cell that is part of the glomerular capillary of the kidney." []
subset: cellxgene_subset
subset: human_reference_atlas
xref: KUPO:0001037
is_a: CL:0002188 ! glomerular endothelial cell
is_a: CL:1000892 ! kidney capillary endothelial cell
intersection_of: CL:1000892 ! kidney capillary endothelial cell
intersection_of: part_of UBERON:0004294 ! glomerular capillary endothelium
relationship: part_of UBERON:0004294 ! glomerular capillary endothelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001005" xsd:string {name="glomerular capillary endothelial cell on CELLxGENE CellGuide"}
[Term]
id: CL:1001006
name: kidney afferent arteriole cell
def: "An endothelial cell which is part of the afferent arteriole in the kidney. This cell is responsible for maintaining renal blood flow and glomerular filtration rate." [PMID:16990493, PMID:22733355, PMID:24066938, PMID:25834230]
xref: KUPO:0001038
is_a: CL:0002681 ! kidney cortical cell
is_a: CL:1000891 {is_inferred="true"} ! kidney arterial blood vessel cell
intersection_of: CL:1000891 ! kidney arterial blood vessel cell
intersection_of: part_of UBERON:0004639 ! renal afferent arteriole
relationship: part_of UBERON:0004639 ! renal afferent arteriole
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001006" xsd:string {name="kidney afferent arteriole cell on CELLxGENE CellGuide"}
[Term]
id: CL:1001009
name: kidney efferent arteriole cell
def: "Any kidney arterial blood vessel cell that is part of some renal efferent arteriole." [FBC:Autogenerated]
xref: KUPO:0001041
is_a: CL:0002681 ! kidney cortical cell
is_a: CL:1000891 ! kidney arterial blood vessel cell
intersection_of: CL:1000891 ! kidney arterial blood vessel cell
intersection_of: part_of UBERON:0004640 ! renal efferent arteriole
relationship: part_of UBERON:0004640 ! renal efferent arteriole
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001009" xsd:string {name="kidney efferent arteriole cell on CELLxGENE CellGuide"}
[Term]
id: CL:1001016
name: kidney loop of Henle ascending limb epithelial cell
def: "Any kidney loop of Henle epithelial cell that is part of some ascending limb of loop of Henle." [FBC:Autogenerated]
subset: cellxgene_subset
subset: kidney_upper_slim
xref: KUPO:0001048
is_a: CL:0002305 ! epithelial cell of distal tubule
is_a: CL:1000909 {is_inferred="true"} ! kidney loop of Henle epithelial cell
intersection_of: CL:1000909 ! kidney loop of Henle epithelial cell
intersection_of: part_of UBERON:0005164 ! ascending limb of loop of Henle
relationship: part_of UBERON:0005164 ! ascending limb of loop of Henle
[Term]
id: CL:1001021
name: kidney loop of Henle descending limb epithelial cell
def: "Any kidney loop of Henle epithelial cell that is part of some descending limb of loop of Henle." [FBC:Autogenerated]
subset: cellxgene_subset
subset: kidney_upper_slim
xref: KUPO:0001053
is_a: CL:1000909 {is_inferred="true"} ! kidney loop of Henle epithelial cell
intersection_of: CL:1000909 ! kidney loop of Henle epithelial cell
intersection_of: part_of UBERON:0001289 ! descending limb of loop of Henle
relationship: part_of UBERON:0001289 ! descending limb of loop of Henle
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001021" xsd:string {name="kidney loop of Henle descending limb epithelial cell on CELLxGENE CellGuide"}
[Term]
id: CL:1001033
name: peritubular capillary endothelial cell
def: "An endothelial cell that is part of the peritubular capillary of the kidney. This cell is highly fenestrated and plays a vital role in the kidney's filtration process, enabling the exchange of materials between the blood and the renal tubules." [PMID:19129259]
comment: Peritubular capillary endothelial cells feature fenestrations measuring 60-70 nm in diameter, each traversed by a thin diaphragm. {xref="PMID:19129259"}
subset: cellxgene_subset
subset: human_reference_atlas
xref: KUPO:0001065
is_a: CL:0000666 ! fenestrated endothelial cell
is_a: CL:1000892 ! kidney capillary endothelial cell
intersection_of: CL:1000892 ! kidney capillary endothelial cell
intersection_of: part_of UBERON:0012441 ! endothelium of peritubular capillary
relationship: part_of UBERON:0012441 ! endothelium of peritubular capillary
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1001036
name: vasa recta cell
def: "A cell that is part of a vasa recta." [PMID:12529271, PMID:24381184]
subset: cellxgene_subset
xref: KUPO:0001068
is_a: CL:1000504 {is_inferred="true"} ! kidney medulla cell
is_a: CL:2000008 ! microvascular endothelial cell
intersection_of: CL:2000008 ! microvascular endothelial cell
intersection_of: part_of UBERON:0004726 ! vasa recta
relationship: part_of UBERON:0004726 ! vasa recta
[Term]
id: CL:1001045
name: kidney cortex artery cell
def: "Any kidney arterial blood vessel cell that is part of some renal cortex artery." [FBC:Autogenerated]
subset: cellxgene_subset
xref: KUPO:0001077
is_a: CL:0002681 ! kidney cortical cell
is_a: CL:1000891 ! kidney arterial blood vessel cell
intersection_of: CL:1000891 ! kidney arterial blood vessel cell
intersection_of: part_of UBERON:0005268 ! renal cortex artery
relationship: part_of UBERON:0005268 ! renal cortex artery
[Term]
id: CL:1001052
name: kidney cortex vein cell
def: "Any kidney venous blood vessel cell that is part of some renal cortex vein." [FBC:Autogenerated]
xref: KUPO:0001084
is_a: CL:0002681 ! kidney cortical cell
is_a: CL:1000893 {is_inferred="true"} ! kidney venous blood vessel cell
intersection_of: CL:1000893 ! kidney venous blood vessel cell
intersection_of: part_of UBERON:0005269 ! renal cortex vein
relationship: part_of UBERON:0005269 ! renal cortex vein
[Term]
id: CL:1001064
name: kidney artery smooth muscle cell
comment: Note that the source of this term is KUPO:0001096 (artery smooth muscle cell), which we believe actually denotes the kidney specific structure.
xref: KUPO:0001096
is_a: CL:0019018 ! blood vessel smooth muscle cell
is_a: CL:1000891 ! kidney arterial blood vessel cell
[Term]
id: CL:1001066
name: kidney arteriole smooth muscle cell
comment: Note that the source of this term is KUPO:0001098 (arteriole smooth muscle cell), which we believe actually denotes the kidney specific structure.
xref: KUPO:0001098
is_a: CL:0019018 ! blood vessel smooth muscle cell
is_a: CL:1000891 ! kidney arterial blood vessel cell
[Term]
id: CL:1001068
name: kidney venous system smooth muscle cell
comment: Note that the source of this term is KUPO:0001068 (venous system smooth muscle cell), which we believe actually denotes the kidney specific structure.
xref: KUPO:0001100
is_a: CL:0019018 ! blood vessel smooth muscle cell
is_a: CL:1000893 ! kidney venous blood vessel cell
[Term]
id: CL:1001096
name: kidney afferent arteriole endothelial cell
def: "An endothelial cell that lines the interior surface of the afferent arteriole and maintains vascular tone. This cell responds to changing ion concentrations and blood pressure by releasing vasoactive substances, in order to regulate blood flow into the glomeruli, which is essential for glomerular filtration." [PMID:16990493, PMID:22733355, PMID:24066938, PMID:25834230]
subset: cellxgene_subset
subset: human_reference_atlas
xref: KUPO:0001039
is_a: CL:1000412 ! endothelial cell of arteriole
is_a: CL:1001006 ! kidney afferent arteriole cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0004639 ! renal afferent arteriole
relationship: part_of UBERON:0004639 ! renal afferent arteriole
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001096" xsd:string {name="kidney afferent arteriole endothelial cell on CELLxGENE CellGuide"}
[Term]
id: CL:1001097
name: kidney afferent arteriole smooth muscle cell
def: "A smooth muscle cell found in the wall of the afferent arteriole. This cell contracts and relaxes in response to changes in blood pressure, a process known as a myogenic response, to alter artery diameter and regulate blood flow into the glomeruli." [PMID:16990493, PMID:22733355, PMID:24066938, PMID:25834230]
xref: KUPO:0001040
is_a: CL:0008035 ! microcirculation associated smooth muscle cell
is_a: CL:1001006 ! kidney afferent arteriole cell
is_a: CL:1001066 ! kidney arteriole smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0004639 ! renal afferent arteriole
relationship: part_of UBERON:0004639 ! renal afferent arteriole
[Term]
id: CL:1001099
name: kidney efferent arteriole endothelial cell
def: "Any endothelial cell that is part of some renal efferent arteriole." [FBC:Autogenerated]
subset: cellxgene_subset
subset: human_reference_atlas
xref: KUPO:0001042
is_a: CL:1000412 ! endothelial cell of arteriole
is_a: CL:1001009 ! kidney efferent arteriole cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0004640 ! renal efferent arteriole
relationship: part_of UBERON:0004640 ! renal efferent arteriole
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001099" xsd:string {name="kidney efferent arteriole endothelial cell on CELLxGENE CellGuide"}
[Term]
id: CL:1001100
name: kidney efferent arteriole smooth muscle cell
def: "Any smooth muscle cell that is part of some renal efferent arteriole." [FBC:Autogenerated]
xref: KUPO:0001043
is_a: CL:0008035 ! microcirculation associated smooth muscle cell
is_a: CL:1001009 ! kidney efferent arteriole cell
is_a: CL:1001066 ! kidney arteriole smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0004640 ! renal efferent arteriole
relationship: part_of UBERON:0004640 ! renal efferent arteriole
[Term]
id: CL:1001106
name: kidney loop of Henle thick ascending limb epithelial cell
def: "An epithelial cell that is part of some loop of Henle thick ascending limb. It is known in some mammalian species that this cell may express the Na+-K+-2Cl− cotransporter (NKCC2) apically." [PMID:25318757]
subset: cellxgene_subset
subset: human_reference_atlas
xref: KUPO:0001049
is_a: CL:1000504 ! kidney medulla cell
is_a: CL:1001016 {is_inferred="true"} ! kidney loop of Henle ascending limb epithelial cell
intersection_of: CL:1001016 ! kidney loop of Henle ascending limb epithelial cell
intersection_of: part_of UBERON:0001291 ! thick ascending limb of loop of Henle
relationship: part_of UBERON:0001291 ! thick ascending limb of loop of Henle
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1001107
name: kidney loop of Henle thin ascending limb epithelial cell
def: "An epithelial cell that is part of some loop of Henle thin ascending limb." []
subset: cellxgene_subset
subset: human_reference_atlas
xref: KUPO:0001050
is_a: CL:1000617 ! kidney inner medulla cell
is_a: CL:1001016 {is_inferred="true"} ! kidney loop of Henle ascending limb epithelial cell
intersection_of: CL:1001016 ! kidney loop of Henle ascending limb epithelial cell
intersection_of: part_of UBERON:0004193 ! loop of Henle ascending limb thin segment
relationship: part_of UBERON:0004193 ! loop of Henle ascending limb thin segment
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1001108
name: kidney loop of Henle medullary thick ascending limb epithelial cell
def: "An epithelial cell that is part of some loop of Henle thick ascending limb segment located in the renal medulla." []
subset: cellxgene_subset
subset: human_reference_atlas
xref: KUPO:0001051
is_a: CL:1000616 {is_inferred="true"} ! kidney outer medulla cell
is_a: CL:1001106 ! kidney loop of Henle thick ascending limb epithelial cell
intersection_of: CL:1001016 ! kidney loop of Henle ascending limb epithelial cell
intersection_of: part_of UBERON:0006376 ! premacula segment of distal straight tubule
relationship: part_of UBERON:0006376 ! premacula segment of distal straight tubule
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1001109
name: kidney loop of Henle cortical thick ascending limb epithelial cell
def: "An epithelial cell that is part of some loop of Henle thick ascending limb segment located in the renal cortex." []
subset: cellxgene_subset
subset: human_reference_atlas
xref: KUPO:0001052
is_a: CL:1001106 ! kidney loop of Henle thick ascending limb epithelial cell
intersection_of: CL:1001016 ! kidney loop of Henle ascending limb epithelial cell
intersection_of: part_of UBERON:0006854 ! distal straight tubule postmacula segment
relationship: part_of UBERON:0006854 ! distal straight tubule postmacula segment
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1001111
name: kidney loop of Henle thin descending limb epithelial cell
def: "An epithelial cell that is part of some loop of Henle thin descending limb." []
subset: cellxgene_subset
subset: human_reference_atlas
xref: KUPO:0001054
is_a: CL:1000453 ! epithelial cell of intermediate tubule
is_a: CL:1000616 ! kidney outer medulla cell
is_a: CL:1001021 {is_inferred="true"} ! kidney loop of Henle descending limb epithelial cell
intersection_of: CL:1001021 ! kidney loop of Henle descending limb epithelial cell
intersection_of: part_of UBERON:0005096 ! descending thin limb
relationship: part_of UBERON:0005096 ! descending thin limb
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1001123
name: kidney outer medulla peritubular capillary cell
def: "An endothelial cell that is part of the peritubular capillary of the outer renal medulla." []
xref: KUPO:0001066
is_a: CL:1000616 ! kidney outer medulla cell
is_a: CL:1001033 ! peritubular capillary endothelial cell
intersection_of: CL:1001033 ! peritubular capillary endothelial cell
intersection_of: part_of UBERON:0006341 ! outer renal medulla peritubular capillary
relationship: part_of UBERON:0006341 ! outer renal medulla peritubular capillary
[Term]
id: CL:1001124
name: kidney cortex peritubular capillary cell
def: "An endothelial cell that is part of the peritubular capillary of the renal cortex." []
xref: KUPO:0001067
is_a: CL:0002681 ! kidney cortical cell
is_a: CL:1001033 ! peritubular capillary endothelial cell
intersection_of: CL:1001033 ! peritubular capillary endothelial cell
intersection_of: part_of UBERON:0006851 ! renal cortex peritubular capillary
relationship: part_of UBERON:0006851 ! renal cortex peritubular capillary
[Term]
id: CL:1001126
name: inner renal medulla vasa recta cell
def: "Any vasa recta cell that is part of some inner renal medulla vasa recta." [FBC:Autogenerated]
xref: KUPO:0001069
is_a: CL:1000617 {is_inferred="true"} ! kidney inner medulla cell
is_a: CL:1001036 {is_inferred="true"} ! vasa recta cell
intersection_of: CL:1001036 ! vasa recta cell
intersection_of: part_of UBERON:0004776 ! inner renal medulla vasa recta
relationship: part_of UBERON:0004776 ! inner renal medulla vasa recta
[Term]
id: CL:1001127
name: outer renal medulla vasa recta cell
def: "Any vasa recta cell that is part of some outer renal medulla vasa recta." [FBC:Autogenerated]
xref: KUPO:0001070
is_a: CL:1000616 {is_inferred="true"} ! kidney outer medulla cell
is_a: CL:1001036 {is_inferred="true"} ! vasa recta cell
intersection_of: CL:1001036 ! vasa recta cell
intersection_of: part_of UBERON:0004775 ! outer renal medulla vasa recta
relationship: part_of UBERON:0004775 ! outer renal medulla vasa recta
[Term]
id: CL:1001131
name: vasa recta ascending limb cell
def: "A cell that is part of some vasa recta ascending limb." []
comment: It is known in some mammalian species that this cell may express PV-1, a component of the fenestral diaphragm. {xref="PMID:20392799", xref="PMID:20392798", xref="PMID:26062876"}
subset: cellxgene_subset
subset: human_reference_atlas
xref: KUPO:0001074
is_a: CL:1001036 {is_inferred="true"} ! vasa recta cell
intersection_of: CL:1001036 ! vasa recta cell
intersection_of: part_of UBERON:0009091 ! ascending vasa recta
relationship: part_of UBERON:0009091 ! ascending vasa recta
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001131" xsd:string {name="vasa recta ascending limb cell on CELLxGENE CellGuide"}
[Term]
id: CL:1001135
name: arcuate artery cell
def: "Any kidney cortex artery cell that is part of some kidney arcuate artery." [FBC:Autogenerated]
xref: KUPO:0001078
is_a: CL:1001045 {is_inferred="true"} ! kidney cortex artery cell
intersection_of: CL:1001045 ! kidney cortex artery cell
intersection_of: part_of UBERON:0001552 ! kidney arcuate artery
relationship: part_of UBERON:0001552 ! kidney arcuate artery
[Term]
id: CL:1001138
name: interlobular artery cell
def: "Any kidney cortex artery cell that is part of some interlobular artery." [FBC:Autogenerated]
xref: KUPO:0001081
is_a: CL:1001045 {is_inferred="true"} ! kidney cortex artery cell
intersection_of: CL:1001045 ! kidney cortex artery cell
intersection_of: part_of UBERON:0004723 ! interlobular artery
relationship: part_of UBERON:0004723 ! interlobular artery
[Term]
id: CL:1001142
name: arcuate vein cell
def: "Any kidney cortex vein cell that is part of some kidney arcuate vein." [FBC:Autogenerated]
xref: KUPO:0001085
is_a: CL:1001052 {is_inferred="true"} ! kidney cortex vein cell
intersection_of: CL:1001052 ! kidney cortex vein cell
intersection_of: part_of UBERON:0004719 ! kidney arcuate vein
relationship: part_of UBERON:0004719 ! kidney arcuate vein
[Term]
id: CL:1001145
name: interlobular vein cell
def: "Any kidney cortex vein cell that is part of some renal interlobular vein." [FBC:Autogenerated]
xref: KUPO:0001088
is_a: CL:1001052 {is_inferred="true"} ! kidney cortex vein cell
intersection_of: CL:1001052 ! kidney cortex vein cell
intersection_of: part_of UBERON:0005168 ! renal interlobular vein
relationship: part_of UBERON:0005168 ! renal interlobular vein
[Term]
id: CL:1001209
name: inner medulla vasa recta ascending limb cell
def: "Any vasa recta ascending limb cell that is part of some inner medulla ascending vasa recta." [FBC:Autogenerated]
xref: KUPO:0001075
is_a: CL:1001126 {is_inferred="true"} ! inner renal medulla vasa recta cell
is_a: CL:1001131 {is_inferred="true"} ! vasa recta ascending limb cell
intersection_of: CL:1001131 ! vasa recta ascending limb cell
intersection_of: part_of UBERON:0009092 ! inner medulla ascending vasa recta
relationship: part_of UBERON:0009092 ! inner medulla ascending vasa recta
[Term]
id: CL:1001210
name: outer medulla vasa recta ascending limb cell
def: "Any vasa recta ascending limb cell that is part of some outer medulla ascending vasa recta." [FBC:Autogenerated]
xref: KUPO:0001076
is_a: CL:1001127 {is_inferred="true"} ! outer renal medulla vasa recta cell
is_a: CL:1001131 {is_inferred="true"} ! vasa recta ascending limb cell
intersection_of: CL:1001131 ! vasa recta ascending limb cell
intersection_of: part_of UBERON:0009093 ! outer medulla ascending vasa recta
relationship: part_of UBERON:0009093 ! outer medulla ascending vasa recta
[Term]
id: CL:1001213
name: arcuate artery endothelial cell
def: "Any endothelial cell that is part of some kidney arcuate artery." [FBC:Autogenerated]
xref: KUPO:0001079
is_a: CL:1000413 ! endothelial cell of artery
is_a: CL:1001135 ! arcuate artery cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0001552 ! kidney arcuate artery
relationship: part_of UBERON:0001552 ! kidney arcuate artery
[Term]
id: CL:1001214
name: arcuate artery smooth muscle cell
def: "Any smooth muscle cell that is part of some kidney arcuate artery." [FBC:Autogenerated]
xref: KUPO:0001080
is_a: CL:1001064 ! kidney artery smooth muscle cell
is_a: CL:1001135 ! arcuate artery cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0001552 ! kidney arcuate artery
relationship: part_of UBERON:0001552 ! kidney arcuate artery
[Term]
id: CL:1001216
name: interlobulary artery endothelial cell
def: "Any endothelial cell that is part of some interlobular artery." [FBC:Autogenerated]
xref: KUPO:0001082
is_a: CL:1000413 ! endothelial cell of artery
is_a: CL:1001138 ! interlobular artery cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0004723 ! interlobular artery
relationship: part_of UBERON:0004723 ! interlobular artery
[Term]
id: CL:1001217
name: interlobulary artery smooth muscle cell
def: "Any smooth muscle cell that is part of some interlobular artery." [FBC:Autogenerated]
xref: KUPO:0001083
is_a: CL:1001064 ! kidney artery smooth muscle cell
is_a: CL:1001138 ! interlobular artery cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0004723 ! interlobular artery
relationship: part_of UBERON:0004723 ! interlobular artery
[Term]
id: CL:1001220
name: arcuate vein endothelial cell
def: "Any endothelial cell that is part of some kidney arcuate vein." [FBC:Autogenerated]
xref: KUPO:0001086
is_a: CL:0002543 ! vein endothelial cell
is_a: CL:1001142 ! arcuate vein cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0004719 ! kidney arcuate vein
relationship: part_of UBERON:0004719 ! kidney arcuate vein
[Term]
id: CL:1001221
name: arcuate vein smooth muscle cell
def: "Any smooth muscle cell that is part of some kidney arcuate vein." [FBC:Autogenerated]
xref: KUPO:0001087
is_a: CL:1001068 ! kidney venous system smooth muscle cell
is_a: CL:1001142 ! arcuate vein cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0004719 ! kidney arcuate vein
relationship: part_of UBERON:0004719 ! kidney arcuate vein
[Term]
id: CL:1001223
name: interlobulary vein endothelial cell
def: "Any endothelial cell that is part of some renal interlobular vein." [FBC:Autogenerated]
xref: KUPO:0001089
is_a: CL:0002543 ! vein endothelial cell
is_a: CL:1001145 ! interlobular vein cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0005168 ! renal interlobular vein
relationship: part_of UBERON:0005168 ! renal interlobular vein
[Term]
id: CL:1001224
name: interlobulary vein smooth muscle cell
def: "Any smooth muscle cell that is part of some renal interlobular vein." [FBC:Autogenerated]
xref: KUPO:0001090
is_a: CL:1001068 ! kidney venous system smooth muscle cell
is_a: CL:1001145 ! interlobular vein cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0005168 ! renal interlobular vein
relationship: part_of UBERON:0005168 ! renal interlobular vein
[Term]
id: CL:1001225
name: kidney collecting duct cell
def: "A cell that is part of a collecting duct of renal tubule." []
subset: cellxgene_subset
xref: KUPO:0001012
xref: Wikipedia:Kidney_collecting_duct_cell
is_a: CL:1000497 ! kidney cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0001232 ! collecting duct of renal tubule
relationship: part_of UBERON:0001232 ! collecting duct of renal tubule
[Term]
id: CL:1001285
name: vasa recta descending limb cell
def: "A cell that is part of some vasa recta descending limb." []
comment: It is known in some mammalian species that this cell may express the urea transporter B. {xref="PMID:20392799", xref="PMID:20392798", xref="PMID:26062876"}
subset: cellxgene_subset
subset: human_reference_atlas
xref: KUPO:0001071
is_a: CL:1001036 {is_inferred="true"} ! vasa recta cell
intersection_of: CL:1001036 ! vasa recta cell
intersection_of: part_of UBERON:0009202 ! descending vasa recta
relationship: part_of UBERON:0009202 ! descending vasa recta
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001285" xsd:string {name="vasa recta descending limb cell on CELLxGENE CellGuide"}
[Term]
id: CL:1001286
name: inner medulla vasa recta descending limb cell
def: "Any vasa recta descending limb cell that is part of some inner medulla descending vasa recta." [FBC:Autogenerated]
xref: KUPO:0001072
is_a: CL:1001126 {is_inferred="true"} ! inner renal medulla vasa recta cell
is_a: CL:1001285 {is_inferred="true"} ! vasa recta descending limb cell
intersection_of: CL:1001285 ! vasa recta descending limb cell
intersection_of: part_of UBERON:0009089 ! inner medulla descending vasa recta
relationship: part_of UBERON:0009089 ! inner medulla descending vasa recta
[Term]
id: CL:1001287
name: outer medulla vasa recta descending limb cell
def: "Any vasa recta descending limb cell that is part of some outer medulla descending vasa recta." [FBC:Autogenerated]
xref: KUPO:0001073
is_a: CL:1001127 {is_inferred="true"} ! outer renal medulla vasa recta cell
is_a: CL:1001285 {is_inferred="true"} ! vasa recta descending limb cell
intersection_of: CL:1001285 ! vasa recta descending limb cell
intersection_of: part_of UBERON:0009090 ! outer medulla descending vasa recta
relationship: part_of UBERON:0009090 ! outer medulla descending vasa recta
[Term]
id: CL:1001318
name: renal interstitial pericyte
def: "A pericyte cell located in the kidney interstitium." []
subset: cellxgene_subset
subset: human_reference_atlas
xref: KUPO:0001104
is_a: CL:0000669 {is_inferred="true"} ! pericyte
is_a: CL:1000500 ! kidney interstitial cell
intersection_of: CL:0000669 ! pericyte
intersection_of: part_of UBERON:0005215 ! kidney interstitium
relationship: part_of UBERON:0005215 ! kidney interstitium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1001319
name: bladder cell
def: "Any cell that is part of some urinary bladder." [FBC:Autogenerated]
subset: cellxgene_subset
subset: human_reference_atlas
xref: KUPO:0001120
is_a: CL:1000600 ! lower urinary tract cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0001255 ! urinary bladder
relationship: part_of UBERON:0001255 ! urinary bladder
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1001320
name: urethra cell
def: "Any cell that is part of some urethra." [FBC:Autogenerated]
xref: KUPO:0001123
is_a: CL:1000600 ! lower urinary tract cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0000057 ! urethra
relationship: part_of UBERON:0000057 ! urethra
[Term]
id: CL:1001428
name: bladder urothelial cell
def: "A urothelial cell that is part of the urothelium of the urinary bladder." [doi:10.1038/s41385-022-00565-0]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "bladder transitional cell" NARROW []
synonym: "transitional epithelial cell of urinary bladder" NARROW []
xref: KUPO:0001121
xref: NCIT:C32210
is_a: CL:0000731 ! urothelial cell
is_a: CL:1001319 ! bladder cell
intersection_of: CL:0000731 ! urothelial cell
intersection_of: part_of UBERON:0004645 ! urinary bladder urothelium
relationship: part_of UBERON:0004645 ! urinary bladder urothelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001428" xsd:string {name="bladder urothelial cell on CELLxGENE CellGuide"}
[Term]
id: CL:1001430
name: urethra urothelial cell
def: "A urothelial cell that is part of the urethra urothelium. This cell plays a crucial role in maintaining the urethral barrier function, protecting against toxic substances in urine, sensing environmental changes, and defending against pathogen entry." [PMID:23589830, PMID:36180582]
subset: cellxgene_subset
xref: KUPO:0001124
is_a: CL:0000731 ! urothelial cell
is_a: CL:1000296 ! epithelial cell of urethra
intersection_of: CL:0000731 ! urothelial cell
intersection_of: part_of UBERON:0004787 ! urethra urothelium
relationship: part_of UBERON:0004787 ! urethra urothelium
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001430" xsd:string {name="urethra urothelial cell on CELLxGENE CellGuide"}
[Term]
id: CL:1001431
name: kidney collecting duct principal cell
def: "Any renal principal cell that is part of some collecting duct of renal tubule." [FBC:Autogenerated]
subset: cellxgene_subset
subset: human_reference_atlas
xref: KUPO:0001128
is_a: CL:0005009 {is_inferred="true"} ! renal principal cell
is_a: CL:1000454 ! kidney collecting duct epithelial cell
intersection_of: CL:0005009 ! renal principal cell
intersection_of: part_of UBERON:0001232 ! collecting duct of renal tubule
relationship: part_of UBERON:0001232 ! collecting duct of renal tubule
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001431" xsd:string {name="kidney collecting duct principal cell on CELLxGENE CellGuide"}
[Term]
id: CL:1001433
name: epithelial cell of exocrine pancreas
def: "An epithelial cell of the exocrine pancreas." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "exocrine pancreas cell" EXACT []
xref: FMA:70986
is_a: CL:0000083 ! epithelial cell of pancreas
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0000017 ! exocrine pancreas
relationship: part_of UBERON:0000017 ! exocrine pancreas
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1001434
name: olfactory bulb interneuron
def: "A neuron residing in the olfactory bulb that serve to process and refine signals arising from olfactory sensory neurons" [PMID:18603310]
is_a: CL:0000099 ! interneuron
is_a: CL:0000101 ! sensory neuron
is_a: CL:0012001 ! neuron of the forebrain
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0002100 UBERON:0002264 ! has soma location olfactory bulb
relationship: part_of UBERON:0002264 ! olfactory bulb
relationship: RO:0002100 UBERON:0002264 ! has soma location olfactory bulb
[Term]
id: CL:1001451
name: sensory neuron of dorsal root ganglion
def: "A sensory neuron of the dorsal root ganglia that senses body position and sends information about how much the muscle is stretched to the spinal cord." [MP:0004297]
subset: cellxgene_subset
synonym: "proprioceptive neuron" EXACT [MP:0004297]
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:3000004 ! peripheral sensory neuron
is_a: CL:4023168 ! somatosensory neuron
intersection_of: CL:0000101 ! sensory neuron
intersection_of: RO:0002100 UBERON:0000044 ! has soma location dorsal root ganglion
relationship: part_of UBERON:0000044 ! dorsal root ganglion
relationship: RO:0002100 UBERON:0000044 ! has soma location dorsal root ganglion
[Term]
id: CL:1001502
name: mitral cell
def: "The large glutaminergic nerve cells whose dendrites synapse with axons of the olfactory receptor neurons in the glomerular layer of the olfactory bulb, and whose axons pass centrally in the olfactory tract to the olfactory cortex." [MP:0009954]
is_a: CL:1001434 ! olfactory bulb interneuron
relationship: RO:0002100 UBERON:0004186 ! has soma location olfactory bulb mitral cell layer
[Term]
id: CL:1001503
name: olfactory bulb tufted cell
def: "The principal glutaminergic neuron located in the outer third of the external plexiform layer of the olfactory bulb; a single short primary dendrite traverses the outer external plexiform layer and terminates within an olfactory glomerulus in a tuft of branches, where it receives the input from olfactory receptor neuron axon terminals; axons of the tufted cells transfer information to a number of areas in the brain, including the piriform cortex, entorhinal cortex, olfactory tubercle, and amygdala." [MP:0009955]
is_a: CL:0012001 ! neuron of the forebrain
relationship: RO:0002100 UBERON:0005376 ! has soma location olfactory bulb external plexiform layer
[Term]
id: CL:1001505
name: parvocellular neurosecretory cell
def: "The secretory neurons of the paraventricular nucleus that synthesize and secrete vasopressin, corticotropin-releasing factor (CRF) and thyrotropin-releasing hormone (TRH) into blood vessels in the hypothalamo-pituitary portal system." [MP:0010125]
synonym: "parvocellular neuron" EXACT []
synonym: "parvocellular neurosecretory neuron" EXACT []
is_a: CL:0000165 ! neuroendocrine cell
is_a: CL:0000167 ! peptide hormone secreting cell
is_a: CL:0012001 ! neuron of the forebrain
is_a: CL:2000030 ! hypothalamus cell
relationship: capable_of GO:0030103 ! vasopressin secretion
relationship: part_of UBERON:0001930 ! paraventricular nucleus of hypothalamus
[Term]
id: CL:1001516
name: intestinal enteroendocrine cell
def: "The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract." [MP:0010802]
subset: cellxgene_subset
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0002563 ! intestinal epithelial cell
intersection_of: CL:0000164 ! enteroendocrine cell
intersection_of: part_of UBERON:0001277 ! intestinal epithelium
relationship: develops_from CL:4052006 ! intestinal enteroendocrine progenitor
relationship: develops_from UBERON:0000160 ! intestine
relationship: develops_from UBERON:0001007 ! digestive system
relationship: develops_from UBERON:0001242 ! intestinal mucosa
relationship: develops_from UBERON:0001262 ! wall of intestine
relationship: develops_from UBERON:0001555 ! digestive tract
relationship: develops_from UBERON:0001983 ! crypt of Lieberkuhn
relationship: develops_from UBERON:0005409 ! alimentary part of gastrointestinal system
relationship: develops_from UBERON:0011184 ! epithelium of crypt of Lieberkuhn
relationship: directly_develops_from CL:4052006 ! intestinal enteroendocrine progenitor
relationship: part_of UBERON:0001277 ! intestinal epithelium
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001516" xsd:string {name="intestinal enteroendocrine cell on CELLxGENE CellGuide"}
[Term]
id: CL:1001517
name: stomach enteroendocrine cell
def: "The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the stomach." [MP:0010803]
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0002178 ! epithelial cell of stomach
intersection_of: CL:0000164 ! enteroendocrine cell
intersection_of: part_of UBERON:0000945 ! stomach
relationship: part_of UBERON:0000945 ! stomach
[Term]
id: CL:1001567
name: lung endothelial cell
def: "Any endothelial cell of vascular tree that is part of some lung." [FBC:Autogenerated]
subset: cellxgene_subset
synonym: "endothelial cell of lung" RELATED []
synonym: "pulmonary vessel endothelial cell" RELATED []
is_a: CL:0002139 ! endothelial cell of vascular tree
intersection_of: CL:0002139 ! endothelial cell of vascular tree
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0000102 ! lung vasculature
relationship: part_of UBERON:0002048 ! lung
[Term]
id: CL:1001568
name: pulmonary artery endothelial cell
def: "Any endothelial cell of vascular tree that is part of some pulmonary artery." [FBC:Autogenerated]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "PAEC cell" RELATED [BTO:0001141]
xref: BTO:0001141
is_a: CL:1000413 ! endothelial cell of artery
intersection_of: CL:0002139 ! endothelial cell of vascular tree
intersection_of: part_of UBERON:0002012 ! pulmonary artery
relationship: part_of UBERON:0002012 ! pulmonary artery
relationship: part_of UBERON:0005317 ! pulmonary artery endothelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1001569
name: hippocampal interneuron
def: "An interneuron with a soma found in the hippocampus." [GOC:pr]
subset: cellxgene_subset
xref: FMA:84777
is_a: CL:0002608 ! hippocampal neuron
is_a: CL:0008031 ! cortical interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0002100 UBERON:0002421 ! has soma location hippocampal formation
relationship: RO:0002100 UBERON:0002421 ! has soma location hippocampal formation
[Term]
id: CL:1001571
name: hippocampal pyramidal neuron
def: "A pyramidal neuron with a soma found in the hippocampus." [GOC:pr, PMID:19342486]
subset: cellxgene_subset
synonym: "hippocampus (CA) pyramidal cell" NARROW [NIFSTD:sao131261273]
synonym: "hippocampus (CA) pyramidal neuron" NARROW [NIFSTD:sao131261273]
xref: NIFSTD:sao131261273
xref: SAO:sao131261273
is_a: CL:0002608 ! hippocampal neuron
is_a: CL:4023111 ! cerebral cortex pyramidal neuron
intersection_of: CL:0000598 ! pyramidal neuron
intersection_of: RO:0002100 UBERON:0002421 ! has soma location hippocampal formation
relationship: part_of UBERON:0002313 ! hippocampus pyramidal layer
relationship: RO:0002100 UBERON:0002421 ! has soma location hippocampal formation
[Term]
id: CL:1001572
name: colon endothelial cell
def: "A vascular endothelial cell found in colon blood vessels." [https://orcid.org/0000-0001-5208-3432, NPX:PDR]
subset: cellxgene_subset
synonym: "colon endothelial cells" RELATED OMO:0003004 [CALOHA:TS-2397]
synonym: "colonic endothelial cell" RELATED [CALOHA:TS-2397]
xref: CALOHA:TS-2397
is_a: CL:0000131 ! gut endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0001155 ! colon
relationship: part_of UBERON:0001155 ! colon
relationship: part_of UBERON:0013695 ! colon endothelium
[Term]
id: CL:1001573
name: nasopharyngeal epithelial cell
def: "Cell of the nasopharyngeal epithelium." [NPX:PDR]
synonym: "nasopharynx respiratory epithelial cells" RELATED [CALOHA:TS-2398]
xref: CALOHA:TS-2398
is_a: CL:0002251 ! epithelial cell of alimentary canal
is_a: CL:0002631 ! epithelial cell of upper respiratory tract
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001728 ! nasopharynx
relationship: part_of UBERON:0001728 ! nasopharynx
relationship: part_of UBERON:0001951 ! epithelium of nasopharynx
[Term]
id: CL:1001575
name: uterine cervix squamous cell
def: "Squamous cell of uterine cervix epithelium." [NPX:PDR]
synonym: "cervix squamous cell" RELATED [CALOHA:TS-1251]
synonym: "cervix squamous epithelial cell" RELATED [CALOHA:TS-1251]
synonym: "cervix, uterine squamous epithelial cells" RELATED [CALOHA:TS-1251]
synonym: "uterine cervix squamous epithelial cell" RELATED [CALOHA:TS-1251]
synonym: "uterine cervix squamous epithelial cells" RELATED [CALOHA:TS-1251]
xref: CALOHA:TS-1251
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0002535 ! epithelial cell of cervix
intersection_of: CL:0000076 ! squamous epithelial cell
intersection_of: part_of UBERON:0000002 ! uterine cervix
relationship: part_of UBERON:0000002 ! uterine cervix
[Term]
id: CL:1001576
name: oral mucosa squamous cell
def: "Squamous cell of oral epithelium." [NPX:PDR]
subset: cellxgene_subset
synonym: "oral cavity mucosa squamous cell" RELATED [CALOHA:TS-1252]
synonym: "oral cavity mucosa squamous epithelial cell" RELATED [CALOHA:TS-1252]
synonym: "oral mucosa squamous epithelial cell" RELATED [CALOHA:TS-1252]
synonym: "oral mucosa squamous epithelial cells" RELATED [CALOHA:TS-1252]
xref: CALOHA:TS-1252
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0002251 ! epithelial cell of alimentary canal
intersection_of: CL:0000076 ! squamous epithelial cell
intersection_of: part_of UBERON:0002424 ! oral epithelium
relationship: part_of UBERON:0002424 ! oral epithelium
[Term]
id: CL:1001577
name: tonsil squamous cell
def: "Squamous cell of tonsil epithelium." [NPX:PDR]
subset: human_reference_atlas
synonym: "tonsil squamous epithelial cell" RELATED [CALOHA:TS-1253]
synonym: "tonsil squamous epithelial cells" RELATED [CALOHA:TS-1253]
synonym: "tonsillar squamous cell" RELATED [CALOHA:TS-1253]
synonym: "tonsillar squamous epithelial cell" RELATED [CALOHA:TS-1253]
xref: CALOHA:TS-1253
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0002251 ! epithelial cell of alimentary canal
intersection_of: CL:0000076 ! squamous epithelial cell
intersection_of: part_of UBERON:0002372 ! tonsil
relationship: part_of UBERON:0002372 ! tonsil
relationship: part_of UBERON:0013696 ! tonsil epithelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1001578
name: vagina squamous cell
def: "Squamous cell of vaginal epithelium." [NPX:PDR]
synonym: "vagina squamous epithelial cell" RELATED [CALOHA:TS-1254]
synonym: "vagina squamous epithelial cells" RELATED [CALOHA:TS-1254]
synonym: "vaginal squamous cell" RELATED [CALOHA:TS-1254]
synonym: "vaginal squamous epithelial cell" RELATED [CALOHA:TS-1254]
xref: CALOHA:TS-1254
is_a: CL:0000076 ! squamous epithelial cell
intersection_of: CL:0000076 ! squamous epithelial cell
intersection_of: part_of UBERON:0000996 ! vagina
relationship: part_of UBERON:0000996 ! vagina
relationship: part_of UBERON:0001344 ! epithelium of vagina
[Term]
id: CL:1001579
name: cerebral cortex glial cell
def: "Glial cell of cerebral cortex." [NPX:PDR]
synonym: "brain cortex glial cell" RELATED [CALOHA:TS-1256]
synonym: "cerebral cortex glial cells" RELATED [CALOHA:TS-1256]
synonym: "cerebrum cortex glial cell" RELATED [CALOHA:TS-1256]
xref: CALOHA:TS-1256
is_a: CL:0000125 ! glial cell
intersection_of: CL:0000125 ! glial cell
intersection_of: part_of UBERON:0000956 ! cerebral cortex
relationship: part_of UBERON:0000956 ! cerebral cortex
[Term]
id: CL:1001580
name: hippocampal glial cell
def: "A glial cell that is part of the hippocampus." [NPX:PDR]
synonym: "hippocampus glial cell" EXACT [CALOHA:TS-1257]
synonym: "hippocampus neuroglial cell" EXACT [CALOHA:TS-1257]
xref: CALOHA:TS-1257
is_a: CL:1001579 ! cerebral cortex glial cell
intersection_of: CL:0000125 ! glial cell
intersection_of: part_of UBERON:0002421 ! hippocampal formation
relationship: part_of UBERON:0002421 ! hippocampal formation
[Term]
id: CL:1001581
name: lateral ventricle glial cell
def: "Glial cell of lateral ventricle." [NPX:PDR]
synonym: "lateral ventricle glial cells" RELATED [CALOHA:TS-1258]
xref: CALOHA:TS-1258
is_a: CL:0000125 ! glial cell
intersection_of: CL:0000125 ! glial cell
intersection_of: part_of UBERON:0002285 ! telencephalic ventricle
relationship: part_of UBERON:0002285 ! telencephalic ventricle
[Term]
id: CL:1001582
name: lateral ventricle neuron
def: "Neuron of lateral ventricle." [NPX:PDR]
synonym: "lateral ventricle neural cell" RELATED [CALOHA:TS-1261]
synonym: "lateral ventricle neuronal cell" RELATED [CALOHA:TS-1261]
synonym: "lateral ventricle neuronal cells" RELATED [CALOHA:TS-1261]
xref: CALOHA:TS-1261
is_a: CL:0012001 ! neuron of the forebrain
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0002285 ! has soma location telencephalic ventricle
relationship: RO:0002100 UBERON:0002285 ! has soma location telencephalic ventricle
[Term]
id: CL:1001585
name: appendix glandular cell
def: "Glandular cell of appendix epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells." [NPX:PDR]
synonym: "appendix glandular cells" RELATED [CALOHA:TS-1271]
synonym: "caecal appendix glandular cell" RELATED [CALOHA:TS-1271]
synonym: "cecal appendix glandular cell" RELATED [CALOHA:TS-1271]
synonym: "vermiform appendix glandular cell" RELATED [CALOHA:TS-1271]
xref: CALOHA:TS-1271
is_a: CL:0002658 ! glandular cell of the large intestine
is_a: CL:1000405 ! epithelial cell of appendix
intersection_of: CL:0000150 ! glandular secretory epithelial cell
intersection_of: part_of UBERON:0001154 ! vermiform appendix
relationship: part_of UBERON:0001154 ! vermiform appendix
[Term]
id: CL:1001586
name: mammary gland glandular cell
def: "Glandular cell of mammary epithelium. Example: glandular cells of large and intermediate ducts, glandular cells in terminal ducts." [HPA:HPA, NPX:PDR]
synonym: "breast glandular cell" RELATED [CALOHA:TS-1272]
synonym: "breast glandular cells" RELATED [CALOHA:TS-1272]
synonym: "mammary glandular cell" RELATED [CALOHA:TS-1272]
xref: CALOHA:TS-1272
is_a: CL:0000150 ! glandular secretory epithelial cell
is_a: CL:0000152 ! exocrine cell
is_a: CL:0002327 ! mammary gland epithelial cell
intersection_of: CL:0000150 ! glandular secretory epithelial cell
intersection_of: part_of UBERON:0001911 ! mammary gland
relationship: part_of UBERON:0001911 ! mammary gland
relationship: part_of UBERON:0003244 ! epithelium of mammary gland
[Term]
id: CL:1001587
name: uterine cervix secretory cell
def: "Glandular cell of uterine cervix epithelium." [NPX:PDR]
synonym: "cervix glandular cell" RELATED [CALOHA:TS-1273]
synonym: "cervix, uterine glandular cell" RELATED [CALOHA:TS-1273]
synonym: "cervix, uterine glandular cells" RELATED [CALOHA:TS-1273]
synonym: "uterine cervix glandular cell" RELATED []
xref: CALOHA:TS-1273
is_a: CL:0002535 ! epithelial cell of cervix
is_a: CL:1001591 ! oviduct secretory cell
intersection_of: CL:1100001 ! secretory epithelial cell
intersection_of: part_of UBERON:0000002 ! uterine cervix
relationship: part_of UBERON:0000002 ! uterine cervix
[Term]
id: CL:1001588
name: colon glandular cell
def: "Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells." [NPX:PDR]
synonym: "colon glandular cells" RELATED [CALOHA:TS-1274]
xref: CALOHA:TS-1274
is_a: CL:0002658 ! glandular cell of the large intestine
is_a: CL:0011108 ! colon epithelial cell
intersection_of: CL:0000150 ! glandular secretory epithelial cell
intersection_of: part_of UBERON:0001155 ! colon
relationship: part_of UBERON:0001155 ! colon
[Term]
id: CL:1001589
name: duodenum secretory cell
def: "Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell." [NPX:PDR]
synonym: "duodenum glandular cells" NARROW [CALOHA:TS-1275]
xref: CALOHA:TS-1275
is_a: CL:1001598 ! small intestine secretory cell
intersection_of: CL:1100001 ! secretory epithelial cell
intersection_of: part_of UBERON:0002114 ! duodenum
relationship: part_of UBERON:0002114 ! duodenum
relationship: part_of UBERON:0008346 ! duodenal epithelium
[Term]
id: CL:1001590
name: epididymis secretory cell
def: "Glandular cell of epididymal epithelium." [NPX:PDR]
synonym: "epididymal glandular cell" RELATED [CALOHA:TS-1276]
synonym: "epididymis glandular cell" RELATED [CALOHA:TS-1276]
xref: CALOHA:TS-1276
is_a: CL:0000068 ! duct epithelial cell
is_a: CL:1100001 ! secretory epithelial cell
intersection_of: CL:1100001 ! secretory epithelial cell
intersection_of: part_of UBERON:0001301 ! epididymis
relationship: part_of UBERON:0001301 ! epididymis
relationship: part_of UBERON:0004544 ! epididymis epithelium
[Term]
id: CL:1001591
name: oviduct secretory cell
def: "Glandular cell of oviduct epithelium. Example: peg cells, ciliated cells." [HPA:HPA, NPX:PDR]
synonym: "fallopian tube glandular cell" RELATED [CALOHA:TS-1277]
synonym: "fallopian tube glandular cells" RELATED [CALOHA:TS-1277]
synonym: "oviduct glandular cell" RELATED []
synonym: "uterine tube glandular cell" RELATED [CALOHA:TS-1277]
xref: CALOHA:TS-1277
is_a: CL:1100001 ! secretory epithelial cell
intersection_of: CL:1100001 ! secretory epithelial cell
intersection_of: part_of UBERON:0000993 ! oviduct
relationship: part_of UBERON:0000993 ! oviduct
relationship: part_of UBERON:0004804 ! oviduct epithelium
[Term]
id: CL:1001592
name: gallbladder glandular cell
def: "Glandular cell of gallbladder epithelium." [NPX:PDR]
synonym: "gall bladder glandular cell" EXACT [FMA:7202]
synonym: "gall bladder glandular cells" RELATED [CALOHA:TS-1278]
synonym: "gallbladder glandular cells" RELATED [CALOHA:TS-1278]
xref: CALOHA:TS-1278
is_a: CL:0000150 ! glandular secretory epithelial cell
is_a: CL:1000415 ! epithelial cell of gallbladder
intersection_of: CL:0000150 ! glandular secretory epithelial cell
intersection_of: part_of UBERON:0002110 ! gallbladder
relationship: part_of UBERON:0002029 ! epithelium of gall bladder
relationship: part_of UBERON:0002110 ! gallbladder
[Term]
id: CL:1001593
name: parathyroid glandular cell
def: "Glandular (secretory) cell of parathyroid epithelium." [HPA:HPA, NPX:PDR]
synonym: "parathyroid gland glandular cell" RELATED [CALOHA:TS-1279]
synonym: "parathyroid gland glandular cells" RELATED [CALOHA:TS-1279]
xref: CALOHA:TS-1279
is_a: CL:0000150 ! glandular secretory epithelial cell
is_a: CL:0002260 ! epithelial cell of parathyroid gland
intersection_of: CL:0000150 ! glandular secretory epithelial cell
intersection_of: part_of UBERON:0001132 ! parathyroid gland
relationship: part_of UBERON:0001132 ! parathyroid gland
[Term]
id: CL:1001595
name: rectum glandular cell
def: "Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells." [NPX:PDR]
synonym: "rectal glandular cell" RELATED [CALOHA:TS-1281]
synonym: "rectum glandular cells" RELATED [CALOHA:TS-1281]
xref: CALOHA:TS-1281
is_a: CL:0002658 ! glandular cell of the large intestine
intersection_of: CL:0000150 ! glandular secretory epithelial cell
intersection_of: part_of UBERON:0001052 ! rectum
relationship: part_of UBERON:0001052 ! rectum
relationship: part_of UBERON:0003354 ! epithelium of rectum
[Term]
id: CL:1001596
name: salivary gland glandular cell
def: "Glandular cell of salivary gland. Example: Serous cells, mucous cells, cuboidal epithelial cells of the intercalated ducts, simple cuboidal epithelium of the striated ducts, epithelial cells of excretory ducts." [HPA:HPA, NPX:PDR]
subset: cellxgene_subset
synonym: "salivary gland glandular cells" RELATED [CALOHA:TS-1282]
xref: CALOHA:TS-1282
is_a: CL:0000150 ! glandular secretory epithelial cell
is_a: CL:0000152 ! exocrine cell
is_a: CL:0002251 ! epithelial cell of alimentary canal
is_a: CL:0009005 ! salivary gland cell
intersection_of: CL:0000150 ! glandular secretory epithelial cell
intersection_of: part_of UBERON:0001044 ! saliva-secreting gland
relationship: part_of UBERON:0001044 ! saliva-secreting gland
relationship: part_of UBERON:0004809 ! salivary gland epithelium
[Term]
id: CL:1001597
name: seminal vesicle glandular cell
def: "Glandular cell of seminal vesicle epithelium." [NPX:PDR]
subset: cellxgene_subset
synonym: "seminal vesicle glandular cells" RELATED [CALOHA:TS-1283]
xref: CALOHA:TS-1283
is_a: CL:0000068 ! duct epithelial cell
is_a: CL:0000150 ! glandular secretory epithelial cell
intersection_of: CL:0000150 ! glandular secretory epithelial cell
intersection_of: part_of UBERON:0000998 ! seminal vesicle
relationship: part_of UBERON:0000998 ! seminal vesicle
relationship: part_of UBERON:0004805 ! seminal vesicle epithelium
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001597" xsd:string {name="seminal vesicle glandular cell on CELLxGENE CellGuide"}
[Term]
id: CL:1001598
name: small intestine secretory cell
def: "A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) ." [NCI_Thesaurus:Small_Intestinal_Glandular_Cell, NPX:PDR]
synonym: "small bowel glandular cell" RELATED [CALOHA:TS-1286]
synonym: "small intestinal glandular cell" NARROW [CALOHA:TS-1286]
synonym: "small intestine glandular cells" RELATED [CALOHA:TS-1286]
xref: CALOHA:TS-1286
xref: FMA:86928
is_a: CL:0002254 ! epithelial cell of small intestine
is_a: CL:1100001 ! secretory epithelial cell
intersection_of: CL:1100001 ! secretory epithelial cell
intersection_of: part_of UBERON:0002108 ! small intestine
relationship: part_of UBERON:0001902 ! epithelium of small intestine
relationship: part_of UBERON:0002108 ! small intestine
[Term]
id: CL:1001599
name: pancreas exocrine glandular cell
def: "Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts." [HPA:HPA, NPX:PDR]
subset: human_reference_atlas
synonym: "exocrine pancreas glandular cell" RELATED [CALOHA:TS-1242]
synonym: "pancreas exocrine glandular cells" RELATED [CALOHA:TS-1242]
xref: BTO:0000028
xref: CALOHA:TS-1242
is_a: CL:0000150 ! glandular secretory epithelial cell
is_a: CL:0000152 ! exocrine cell
is_a: CL:1001433 ! epithelial cell of exocrine pancreas
intersection_of: CL:0000150 ! glandular secretory epithelial cell
intersection_of: part_of UBERON:0000017 ! exocrine pancreas
relationship: part_of UBERON:0000017 ! exocrine pancreas
relationship: part_of UBERON:0013697 ! exocrine pancreas epithelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1001601
name: adrenal gland glandular cell
def: "Hormone secreting cell located in the cortex of adrenal gland. Glandular cells in the adrenal cortex secrete mineralocorticoids, glucocorticoids and androgens." [NPX:PDR]
synonym: "adrenal gland glandular cells" RELATED [CALOHA:TS-2177]
synonym: "adrenal glandular cell" RELATED [CALOHA:TS-2177]
synonym: "suprarenal gland glandular cell" RELATED [CALOHA:TS-2177]
xref: CALOHA:TS-2177
is_a: CL:0000150 ! glandular secretory epithelial cell
intersection_of: CL:0000150 ! glandular secretory epithelial cell
intersection_of: part_of UBERON:0001235 ! adrenal cortex
relationship: part_of UBERON:0001235 ! adrenal cortex
[Term]
id: CL:1001602
name: cerebral cortex endothelial cell
def: "A distinct endothelial cell forming the walls of the capillaries within the cerebral cortex." [NPX:PDR]
subset: cellxgene_subset
synonym: "cerebral cortex endothelial cells" RELATED [CALOHA:TS-2372]
synonym: "endothelial cells of cerebral cortex" RELATED [CALOHA:TS-2372]
xref: CALOHA:TS-2372
is_a: CL:0000115 ! endothelial cell
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0000956 ! cerebral cortex
relationship: part_of UBERON:0000956 ! cerebral cortex
relationship: part_of UBERON:0013694 ! brain endothelium
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001602" xsd:string {name="cerebral cortex endothelial cell on CELLxGENE CellGuide"}
[Term]
id: CL:1001603
name: lung macrophage
def: "Circulating macrophages and tissue macrophages (alveolar macrophages) of lung." [HPA:HPA, NPX:PDR]
subset: cellxgene_subset
synonym: "lung macrophages" RELATED [CALOHA:TS-0576]
xref: CALOHA:TS-0576
is_a: CL:0000235 ! macrophage
intersection_of: CL:0000235 ! macrophage
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0002048 ! lung
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001603" xsd:string {name="lung macrophage on CELLxGENE CellGuide"}
[Term]
id: CL:1001606
name: foreskin keratinocyte
def: "Keratinocyte from foreskin." [NPX:PDR]
xref: CALOHA:TS-0385
is_a: CL:0000312 ! keratinocyte
intersection_of: CL:0000312 ! keratinocyte
intersection_of: part_of UBERON:0001332 ! prepuce of penis
relationship: part_of UBERON:0001332 ! prepuce of penis
[Term]
id: CL:1001607
name: articular chondrocyte
def: "Chondrocyte forming the hyaline cartilage found in joints." [NPX:PDR]
subset: cellxgene_subset
subset: human_reference_atlas
xref: CALOHA:TS-0056
is_a: CL:0000138 ! chondrocyte
intersection_of: CL:0000138 ! chondrocyte
intersection_of: part_of UBERON:0010996 ! articular cartilage of joint
relationship: part_of UBERON:0010996 ! articular cartilage of joint
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1001608
name: foreskin fibroblast
def: "Fibroblast from foreskin." [NPX:PDR]
synonym: "BJ fibroblast" EXACT []
xref: CALOHA:TS-0384
is_a: CL:0002620 ! skin fibroblast
intersection_of: CL:0002620 ! skin fibroblast
intersection_of: part_of UBERON:0001332 ! prepuce of penis
relationship: part_of UBERON:0001332 ! prepuce of penis
[Term]
id: CL:1001609
name: muscle fibroblast
def: "Fibroblast from muscle organ." [NPX:PDR]
subset: cellxgene_subset
xref: CALOHA:TS-0643
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001630 ! muscle organ
relationship: part_of UBERON:0001630 ! muscle organ
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001609" xsd:string {name="muscle fibroblast on CELLxGENE CellGuide"}
[Term]
id: CL:1001610
name: bone marrow hematopoietic cell
def: "Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes." [NPX:PDR]
synonym: "bone marrow hematopoietic cells" RELATED [CALOHA:TS-2109]
synonym: "bone marrow poietic cells" RELATED [CALOHA:TS-2109]
xref: CALOHA:TS-2109
is_a: CL:0000988 ! hematopoietic cell
is_a: CL:0002092 ! bone marrow cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: part_of UBERON:0002371 ! bone marrow
relationship: part_of UBERON:0002371 ! bone marrow
relationship: part_of UBERON:0012429 ! hematopoietic tissue
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001610" xsd:string {name="bone marrow hematopoietic cell on CELLxGENE CellGuide"}
[Term]
id: CL:1001611
name: cerebellar neuron
def: "Neuron of the cerebellum." [NPX:PDR]
subset: cellxgene_subset
synonym: "cerebellum neuron" RELATED [CALOHA:TS-2359]
xref: CALOHA:TS-2359
xref: FMA:84665
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0002037 ! has soma location cerebellum
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: RO:0002100 UBERON:0002037 ! has soma location cerebellum
[Term]
id: CL:1100001
name: secretory epithelial cell
def: "An epithelial cell that is specialised for the synthesis and secretion of specific biomolecules." [https://orcid.org/0000-0002-7073-9172]
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: CL:0000151 ! secretory cell
relationship: dc-contributor https://orcid.org/0000-0002-7073-9172
property_value: dcterms-date "2024-07-21T09:24:44Z" xsd:dateTime
[Term]
id: CL:2000000
name: epidermal melanocyte
def: "Any melanocyte that is part of a epidermis." [GOC:TermGenie]
comment: These cells are found primarily, but not exclusively, in primates including humans
is_a: CL:0002484 ! epithelial melanocyte
is_a: CL:1000458 ! melanocyte of skin
intersection_of: CL:0000148 ! melanocyte
intersection_of: part_of UBERON:0001003 ! skin epidermis
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0001003 ! skin epidermis
creation_date: 2014-02-03T23:03:09Z
[Term]
id: CL:2000001
name: peripheral blood mononuclear cell
def: "A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood." [GOC:TermGenie]
subset: cellxgene_subset
is_a: CL:0000080 ! circulating cell
is_a: CL:0000842 ! mononuclear leukocyte
intersection_of: CL:0000842 ! mononuclear leukocyte
intersection_of: part_of UBERON:0000178 ! blood
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0000178 ! blood
creation_date: 2014-02-11T17:29:04Z
[Term]
id: CL:2000002
name: decidual cell
def: "A specialized, enlarged, connective tissue cell of the decidua with enlarged nucleus, dense membrane‐bound secretory granules and cytoplasmic accumulation of glycogen and lipid droplets. These cells develop by the transformation of endometrial stromal cells during decidualization." [BTO:0002770, NCIT:C32429, PMID:30013421, PMID:30429548, Wiki:Decidual_cells&oldid=937509751, Wiki:Decidualization&oldid=908981933]
subset: cellxgene_subset
synonym: "decidua cell" EXACT [BTO:0002770, NCIT:C32429]
synonym: "decidual stromal cell" EXACT [BTO:0005756, PMID:11719592]
synonym: "decidualized endometrial stromal cell" EXACT [PMID:31907034]
xref: BTO:0002770
xref: BTO:0005756
xref: NCIT:C32429
is_a: CL:0000349 ! extraembryonic cell
is_a: CL:0000499 ! stromal cell
relationship: develops_from CL:0002255 ! stromal cell of endometrium
relationship: part_of UBERON:0002450 ! decidua
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_2000002" xsd:string {name="decidual cell on CELLxGENE CellGuide"}
creation_date: 2014-02-20T23:06:41Z
[Term]
id: CL:2000004
name: pituitary gland cell
def: "Any cell that is part of a pituitary gland." [GOC:TermGenie]
subset: cellxgene_subset
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0000007 ! pituitary gland
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0000007 ! pituitary gland
creation_date: 2014-03-26T22:14:56Z
[Term]
id: CL:2000005
name: brain macroglial cell
def: "Any macroglial cell that is part of a brain." [GOC:TermGenie]
is_a: CL:0000126 ! macroglial cell
intersection_of: CL:0000126 ! macroglial cell
intersection_of: part_of UBERON:0000955 ! brain
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0000955 ! brain
creation_date: 2014-03-28T21:35:27Z
[Term]
id: CL:2000006
name: tonsil germinal center B cell
def: "Any germinal center B cell that is part of a tonsil." [GOC:TermGenie]
subset: cellxgene_subset
is_a: CL:0000844 ! germinal center B cell
intersection_of: CL:0000844 ! germinal center B cell
intersection_of: part_of UBERON:0002372 ! tonsil
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0002372 ! tonsil
creation_date: 2014-03-28T21:35:33Z
[Term]
id: CL:2000007
name: articular chondrocyte of knee joint
def: "Chondrocyte forming the hyaline cartilage found in the knee joint." [GOC:TermGenie]
is_a: CL:1001607 ! articular chondrocyte
intersection_of: CL:1001607 ! articular chondrocyte
intersection_of: part_of UBERON:0001485 ! knee joint
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0001485 ! knee joint
creation_date: 2014-06-04T14:40:11Z
[Term]
id: CL:2000008
name: microvascular endothelial cell
def: "Any blood vessel endothelial cell that is part of a microvascular endothelium." [GOC:TermGenie]
subset: cellxgene_subset
is_a: CL:0000071 ! blood vessel endothelial cell
intersection_of: CL:0000071 ! blood vessel endothelial cell
intersection_of: part_of UBERON:0008339 ! microvascular endothelium
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0008339 ! microvascular endothelium
creation_date: 2014-06-04T15:07:42Z
[Term]
id: CL:2000010
name: dermis blood vessel endothelial cell
def: "Any blood vessel endothelial cell that is part of a dermis." [GOC:TermGenie]
is_a: CL:0000071 ! blood vessel endothelial cell
intersection_of: CL:0000071 ! blood vessel endothelial cell
intersection_of: part_of UBERON:0002067 ! dermis
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0002067 ! dermis
creation_date: 2014-06-04T15:12:06Z
[Term]
id: CL:2000011
name: dermis lymphatic vessel endothelial cell
def: "Any endothelial cell of lymphatic vessel that is part of a dermis." [GOC:TermGenie]
is_a: CL:0002138 ! endothelial cell of lymphatic vessel
intersection_of: CL:0002138 ! endothelial cell of lymphatic vessel
intersection_of: part_of UBERON:0002067 ! dermis
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0002067 ! dermis
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_2000011" xsd:string {name="dermis lymphatic vessel endothelial cell on CELLxGENE CellGuide"}
creation_date: 2014-06-04T15:15:08Z
[Term]
id: CL:2000012
name: fibroblast of pedal digit skin
def: "Any skin fibroblast that is part of a pedal digit skin." [GOC:TermGenie]
is_a: CL:0002620 ! skin fibroblast
intersection_of: CL:0002620 ! skin fibroblast
intersection_of: part_of UBERON:0003530 ! pedal digit skin
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0003530 ! pedal digit skin
creation_date: 2014-06-04T15:16:44Z
[Term]
id: CL:2000013
name: fibroblast of skin of abdomen
def: "Any skin fibroblast that is part of a skin of abdomen." [GOC:TermGenie]
is_a: CL:0002620 ! skin fibroblast
intersection_of: CL:0002620 ! skin fibroblast
intersection_of: part_of UBERON:0001416 ! skin of abdomen
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0001416 ! skin of abdomen
creation_date: 2014-06-04T15:18:16Z
[Term]
id: CL:2000014
name: fibroblast of upper leg skin
def: "Any skin fibroblast that is part of a upper leg skin." [GOC:TermGenie]
is_a: CL:0002620 ! skin fibroblast
intersection_of: CL:0002620 ! skin fibroblast
intersection_of: part_of UBERON:0004262 ! upper leg skin
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0004262 ! upper leg skin
creation_date: 2014-06-04T15:19:44Z
[Term]
id: CL:2000015
name: fibroblast of arm
def: "Any skin fibroblast that is part of a arm." [GOC:TermGenie]
is_a: CL:0002620 ! skin fibroblast
intersection_of: CL:0002620 ! skin fibroblast
intersection_of: part_of UBERON:0001460 ! arm
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0001460 ! arm
creation_date: 2014-06-04T15:29:06Z
[Term]
id: CL:2000016
name: lung microvascular endothelial cell
def: "Any lung endothelial cell that is part of a microvascular endothelium." [GOC:TermGenie]
subset: cellxgene_subset
is_a: CL:1001567 ! lung endothelial cell
is_a: CL:2000008 ! microvascular endothelial cell
intersection_of: CL:1001567 ! lung endothelial cell
intersection_of: part_of UBERON:0008339 ! microvascular endothelium
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0008339 ! microvascular endothelium
creation_date: 2014-06-04T16:00:56Z
[Term]
id: CL:2000017
name: fibroblast of peridontal ligament
def: "Any fibroblast that is part of a periodontal ligament." [GOC:TermGenie]
is_a: CL:0002556 ! fibroblast of periodontium
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0008266 ! periodontal ligament
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0008266 ! periodontal ligament
creation_date: 2014-06-04T16:50:33Z
[Term]
id: CL:2000018
name: endothelial cell of coronary artery
def: "Any endothelial cell of artery that is part of a coronary artery." [GOC:TermGenie]
subset: cellxgene_subset
is_a: CL:0010006 ! cardiac blood vessel endothelial cell
is_a: CL:1000413 ! endothelial cell of artery
intersection_of: CL:1000413 ! endothelial cell of artery
intersection_of: part_of UBERON:0001621 ! coronary artery
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0001621 ! coronary artery
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_2000018" xsd:string {name="endothelial cell of coronary artery on CELLxGENE CellGuide"}
creation_date: 2014-06-04T17:08:47Z
[Term]
id: CL:2000019
name: compound eye photoreceptor cell
def: "Any photoreceptor cell that is part of a compound eye." [GOC:TermGenie]
xref: FBbt:00006009 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"}
is_a: CL:0000287 ! eye photoreceptor cell
intersection_of: CL:0000210 ! photoreceptor cell
intersection_of: part_of UBERON:0000018 ! compound eye
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0000018 ! compound eye
creation_date: 2014-06-24T23:16:45Z
[Term]
id: CL:2000020
name: inner cell mass cell
def: "Any native cell that is part of a inner cell mass." [GOC:TermGenie]
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0000087 ! inner cell mass
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0000087 ! inner cell mass
creation_date: 2014-06-24T23:16:53Z
[Term]
id: CL:2000021
name: sebaceous gland cell
def: "Any native cell that is part of a sebaceous gland." [GOC:TermGenie]
subset: cellxgene_subset
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0001821 ! sebaceous gland
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0001821 ! sebaceous gland
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_2000021" xsd:string {name="sebaceous gland cell on CELLxGENE CellGuide"}
creation_date: 2014-06-24T23:17:00Z
[Term]
id: CL:2000022
name: cardiac septum cell
def: "Any native cell that is part of a cardiac septum." [GOC:TermGenie]
is_a: CL:0002494 ! cardiocyte
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0002099 ! cardiac septum
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0002099 ! cardiac septum
creation_date: 2014-06-24T23:17:07Z
[Term]
id: CL:2000023
name: spinal cord ventral column interneuron
def: "Any interneuron that is part of a spinal cord ventral column." [GOC:TermGenie]
is_a: CL:0005000 ! spinal cord interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0002100 UBERON:0005375 ! has soma location spinal cord ventral column
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: RO:0002100 UBERON:0005375 ! has soma location spinal cord ventral column
creation_date: 2014-06-25T00:23:36Z
[Term]
id: CL:2000024
name: spinal cord medial motor column neuron
def: "Any neuron that is part of a spinal cord medial motor column." [GOC:TermGenie]
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0004059 ! has soma location spinal cord medial motor column
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: RO:0002100 UBERON:0004059 ! has soma location spinal cord medial motor column
creation_date: 2014-06-25T00:23:43Z
[Term]
id: CL:2000025
name: spinal cord oligodendrocyte
def: "Any oligodendrocyte that is part of a spinal cord." [GOC:TermGenie]
is_a: CL:0000128 ! oligodendrocyte
intersection_of: CL:0000128 ! oligodendrocyte
intersection_of: part_of UBERON:0002240 ! spinal cord
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0002240 ! spinal cord
creation_date: 2014-06-25T00:23:50Z
[Term]
id: CL:2000027
name: cerebellar basket cell
def: "A GABAergic inhibitory interneuron located in the molecular layer of the cerebellar cortex. It projects axons that form specialized synaptic structures around Purkinje cells, including pericellular baskets, which wrap around the Purkinje cell soma, and the pinceau: a brush-like terminal that contacts the initial segment of the Purkinje cell axon. The basket cell modulates Purkinje cell activity through both chemical (GABAergic) and non-synaptic (ephaptic) mechanisms. It is arranged in sagittal rows that align with Purkinje cell zones, contributing to the cerebellum's modular and topographically organized architecture. It plays an essential role in regulating motor coordination and potentially cognitive functions." [PMID:32990595, PMID:8915580]
synonym: "cerebellum basket cell" EXACT []
is_a: CL:0000118 ! basket cell
is_a: CL:4042035 ! molecular layer interneuron
intersection_of: CL:0000118 ! basket cell
intersection_of: RO:0002100 UBERON:0002037 ! has soma location cerebellum
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: RO:0002100 UBERON:0002037 ! has soma location cerebellum
creation_date: 2014-06-25T00:24:03Z
[Term]
id: CL:2000028
name: cerebellum glutamatergic neuron
def: "Any glutamatergic neuron that is part of a cerebellum." [GOC:TermGenie]
subset: cellxgene_subset
is_a: CL:0000679 ! glutamatergic neuron
is_a: CL:1001611 ! cerebellar neuron
intersection_of: CL:0000679 ! glutamatergic neuron
intersection_of: RO:0002100 UBERON:0002037 ! has soma location cerebellum
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: RO:0002100 UBERON:0002037 ! has soma location cerebellum
creation_date: 2014-06-25T00:24:10Z
[Term]
id: CL:2000029
name: central nervous system neuron
def: "Any neuron that is part of a central nervous system." [GOC:TermGenie]
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0001017 ! has soma location central nervous system
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002100 UBERON:0001017 ! has soma location central nervous system
creation_date: 2014-06-25T01:17:43Z
[Term]
id: CL:2000030
name: hypothalamus cell
def: "Any native cell that is part of a hypothalamus." [GOC:TermGenie]
subset: cellxgene_subset
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0001898 ! hypothalamus
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0001898 ! hypothalamus
creation_date: 2014-06-25T01:17:50Z
[Term]
id: CL:2000031
name: lateral line ganglion neuron
def: "Any neuron that is part of a lateral line ganglion." [GOC:TermGenie]
is_a: CL:2000032 ! peripheral nervous system neuron
intersection_of: CL:2000032 ! peripheral nervous system neuron
intersection_of: RO:0002100 UBERON:2000120 ! has soma location lateral line ganglion
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: in_taxon NCBITaxon:32443 ! Teleostei
relationship: RO:0002100 UBERON:2000120 ! has soma location lateral line ganglion
creation_date: 2014-06-25T01:17:57Z
[Term]
id: CL:2000032
name: peripheral nervous system neuron
def: "A neuron that is part of a peripheral nervous system." [GOC:TermGenie, ISBN:0721662544]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "peripheral neuron" EXACT []
synonym: "PNS neuron" EXACT []
xref: FMA:84664
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0000010 ! has soma location peripheral nervous system
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002100 UBERON:0000010 ! has soma location peripheral nervous system
creation_date: 2014-06-25T02:28:17Z
[Term]
id: CL:2000033
name: limb basal cell of epidermis
def: "Any basal cell of epidermis that is part of a limb." [GOC:TermGenie]
is_a: CL:0002187 ! basal cell of epidermis
intersection_of: CL:0002187 ! basal cell of epidermis
intersection_of: part_of UBERON:0002101 ! limb
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0002101 ! limb
creation_date: 2014-06-25T02:28:25Z
[Term]
id: CL:2000034
name: anterior lateral line neuromast hair cell
def: "Any neuromast hair cell that is part of a anterior lateral line." [GOC:TermGenie]
is_a: CL:0000856 ! neuromast hair cell
intersection_of: CL:0000856 ! neuromast hair cell
intersection_of: part_of UBERON:2001470 ! anterior lateral line
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:2001470 ! anterior lateral line
creation_date: 2014-06-25T03:44:37Z
[Term]
id: CL:2000037
name: posterior lateral line neuromast hair cell
def: "Any neuromast hair cell that is part of a posterior lateral line." [GOC:TermGenie]
is_a: CL:0000856 ! neuromast hair cell
intersection_of: CL:0000856 ! neuromast hair cell
intersection_of: part_of UBERON:0006334 ! posterior lateral line
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0006334 ! posterior lateral line
creation_date: 2014-06-25T03:44:57Z
[Term]
id: CL:2000040
name: bladder microvascular endothelial cell
def: "Any microvascular endothelial cell that is part of a urinary bladder." [GOC:TermGenie]
subset: human_reference_atlas
is_a: CL:1001319 ! bladder cell
is_a: CL:2000008 ! microvascular endothelial cell
intersection_of: CL:2000008 ! microvascular endothelial cell
intersection_of: part_of UBERON:0001255 ! urinary bladder
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0001255 ! urinary bladder
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2014-07-09T00:04:47Z
[Term]
id: CL:2000041
name: dermis microvascular lymphatic vessel endothelial cell
def: "Any dermis lymphatic vessel endothelial cell that is part of a microvascular endothelium." [GOC:TermGenie]
subset: cellxgene_subset
is_a: CL:0011030 ! dermal microvascular endothelial cell
is_a: CL:2000011 ! dermis lymphatic vessel endothelial cell
intersection_of: CL:2000011 ! dermis lymphatic vessel endothelial cell
intersection_of: part_of UBERON:0008339 ! microvascular endothelium
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0008339 ! microvascular endothelium
creation_date: 2014-07-09T00:09:54Z
[Term]
id: CL:2000042
name: embryonic fibroblast
def: "Any fibroblast that is part of a embryo." [GOC:TermGenie]
subset: cellxgene_subset
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0000922 ! embryo
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0000922 ! embryo
creation_date: 2014-07-09T00:12:00Z
[Term]
id: CL:2000043
name: brain pericyte
def: "Any pericyte cell that is part of a brain." [GOC:TermGenie]
subset: cellxgene_subset
is_a: CL:0002575 ! central nervous system pericyte
intersection_of: CL:0000669 ! pericyte
intersection_of: part_of UBERON:0000955 ! brain
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0000955 ! brain
creation_date: 2014-07-09T00:18:22Z
[Term]
id: CL:2000044
name: brain microvascular endothelial cell
def: "Any microvascular endothelial cell that is part of a brain." [GOC:TermGenie]
is_a: CL:0002319 ! neural cell
is_a: CL:2000008 ! microvascular endothelial cell
intersection_of: CL:2000008 ! microvascular endothelial cell
intersection_of: part_of UBERON:0000955 ! brain
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0000955 ! brain
creation_date: 2014-07-09T00:24:53Z
[Term]
id: CL:2000045
name: foreskin melanocyte
def: "Any melanocyte of skin that is part of a skin of prepuce of penis." [GOC:TermGenie]
synonym: "melanocyte of foreskin" EXACT []
is_a: CL:1000458 ! melanocyte of skin
intersection_of: CL:1000458 ! melanocyte of skin
intersection_of: part_of UBERON:0001471 ! skin of prepuce of penis
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0001471 ! skin of prepuce of penis
creation_date: 2014-07-09T00:45:07Z
[Term]
id: CL:2000046
name: ventricular cardiac muscle cell
def: "Any cardiac muscle cell that is part of a cardiac ventricle." [GOC:TermGenie]
subset: cellxgene_subset
is_a: CL:0000746 ! cardiac muscle cell
intersection_of: CL:0000746 ! cardiac muscle cell
intersection_of: part_of UBERON:0002082 ! cardiac ventricle
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0002082 ! cardiac ventricle
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_2000046" xsd:string {name="ventricular cardiac muscle cell on CELLxGENE CellGuide"}
creation_date: 2014-08-12T20:50:28Z
[Term]
id: CL:2000047
name: brainstem motor neuron
def: "Any motor neuron that is part of a brainstem." [GOC:TermGenie]
subset: cellxgene_subset
is_a: CL:0000100 ! motor neuron
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000100 ! motor neuron
intersection_of: RO:0002100 UBERON:0002298 ! has soma location brainstem
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: RO:0002100 UBERON:0002298 ! has soma location brainstem
creation_date: 2014-10-02T23:52:53Z
[Term]
id: CL:2000049
name: primary motor cortex pyramidal cell
def: "Any pyramidal cell that is part of a primary motor cortex." [GOC:TermGenie]
comment: http://www.ncbi.nlm.nih.gov/pubmed/12524689
is_a: CL:4023111 ! cerebral cortex pyramidal neuron
intersection_of: CL:0000598 ! pyramidal neuron
intersection_of: RO:0002100 UBERON:0001384 ! has soma location primary motor cortex
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: RO:0002100 UBERON:0001384 ! has soma location primary motor cortex
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_2000049" xsd:string {name="primary motor cortex pyramidal cell on CELLxGENE CellGuide"}
creation_date: 2014-10-06T17:39:04Z
[Term]
id: CL:2000051
name: splenic fibroblast
def: "Any fibroblast that is part of a spleen." [GOC:TermGenie]
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0002106 ! spleen
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0002106 ! spleen
creation_date: 2014-10-06T18:58:47Z
[Term]
id: CL:2000052
name: umbilical artery endothelial cell
def: "Any endothelial cell of artery that is part of a umbilical cord." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=8010
is_a: CL:0000349 ! extraembryonic cell
is_a: CL:1000413 ! endothelial cell of artery
intersection_of: CL:1000413 ! endothelial cell of artery
intersection_of: part_of UBERON:0002331 ! umbilical cord
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0002331 ! umbilical cord
creation_date: 2014-10-06T19:01:48Z
[Term]
id: CL:2000053
name: splenic endothelial cell
def: "Any endothelial cell that is part of a spleen." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=5500
subset: human_reference_atlas
is_a: CL:0000115 ! endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0002106 ! spleen
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0002106 ! spleen
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2014-10-06T19:06:04Z
[Term]
id: CL:2000055
name: liver dendritic cell
def: "Any dendritic cell that is part of a liver." [GOC:TermGenie]
comment: http://www.jleukbio.org/content/66/2/322.abstract
subset: cellxgene_subset
synonym: "hepatic dendritic cell" EXACT []
is_a: CL:0000451 ! dendritic cell
intersection_of: CL:0000451 ! dendritic cell
intersection_of: part_of UBERON:0002107 ! liver
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0002107 ! liver
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_2000055" xsd:string {name="liver dendritic cell on CELLxGENE CellGuide"}
creation_date: 2014-10-06T19:16:11Z
[Term]
id: CL:2000057
name: femoral osteoblast
def: "Any osteoblast that is part of a femur." [GOC:TermGenie, PMID:34565180, PMID:34569806]
is_a: CL:0000062 ! osteoblast
is_a: CL:0001035 ! bone cell
intersection_of: CL:0000062 ! osteoblast
intersection_of: part_of UBERON:0000981 ! femur
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0000981 ! femur
creation_date: 2014-10-06T19:29:45Z
[Term]
id: CL:2000058
name: calvarial osteoblast
def: "Any osteoblast that is part of a skull." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=4600
is_a: CL:0000062 ! osteoblast
intersection_of: CL:0000062 ! osteoblast
intersection_of: part_of UBERON:0003129 ! skull
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0003129 ! skull
creation_date: 2014-10-06T19:48:30Z
[Term]
id: CL:2000059
name: prostate gland microvascular endothelial cell
def: "Any microvascular endothelial cell that is part of a prostate gland." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=4400
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:2000008 ! microvascular endothelial cell
intersection_of: CL:2000008 ! microvascular endothelial cell
intersection_of: part_of UBERON:0002367 ! prostate gland
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0002367 ! prostate gland
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2014-10-07T17:46:27Z
[Term]
id: CL:2000060
name: placental villous trophoblast
def: "A trophoblast of placental villi. These cells fuse to form synctial trophoplast - the placental side of the interface between the placenta and maternal blood sinusoids in the decidua." [PMID:31049600]
comment: Same as synctial trophoblast?
subset: cellxgene_subset
synonym: "vCTB" EXACT [PMID:31049600]
synonym: "villous cytotrophoblast" EXACT []
xref: BTO:0006119
xref: BTO:0006208
is_a: CL:0000351 ! trophoblast cell
intersection_of: CL:0000351 ! trophoblast cell
intersection_of: part_of UBERON:0010005 ! placental labyrinth villous
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0010005 ! placental labyrinth villous
property_value: seeAlso "http://www.sciencellonline.com/site/productInformation.php?keyword=7120" xsd:string
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_2000060" xsd:string {name="placental villous trophoblast on CELLxGENE CellGuide"}
creation_date: 2014-10-07T17:48:27Z
[Term]
id: CL:2000061
name: placental amniotic mesenchymal stromal cell
def: "Any mesenchymal stem cell that is part of a placenta." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7140
subset: human_reference_atlas
is_a: CL:0000134 ! mesenchymal stem cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: part_of UBERON:0001987 ! placenta
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0001987 ! placenta
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2014-10-07T17:51:11Z
[Term]
id: CL:2000062
name: placental villus capillary endothelial cell
def: "Any capillary endothelial cell that is part of a placenta." [GOC:TermGenie]
comment: http://www.ncbi.nlm.nih.gov/books/NBK53245/
subset: human_reference_atlas
is_a: CL:0002144 ! capillary endothelial cell
is_a: CL:0009092 ! endothelial cell of placenta
intersection_of: CL:0002144 ! capillary endothelial cell
intersection_of: part_of UBERON:0001987 ! placenta
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0001987 ! placenta
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2014-10-07T17:55:56Z
[Term]
id: CL:2000063
name: ovarian fibroblast
def: "Any fibroblast that is part of a female gonad." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7330
is_a: CL:0000057 ! fibroblast
is_a: CL:0002132 ! stromal cell of ovary
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0000992 ! ovary
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0000992 ! ovary
creation_date: 2014-10-07T17:57:42Z
[Term]
id: CL:2000064
name: ovarian surface epithelial cell
def: "A meso-epithelial cell of the ovarian surface epithelium, varying in shape from flat to cuboidal to pseudostratified columnar. This cell plays a crucial role in ovulation by producing proteolytic enzymes in response to gonadotropins, facilitating follicle rupture through tissue breakdown and TNF-alpha signaling. Additionally, this cell contributes to post-ovulatory wound repair (Morris et al., 2022) and exhibits stem cell-like properties (Flesken-Nikitin et al., 2013; Wang et al., 2019)." [GOC:TermGenie, PMID:12052228, PMID:15749958, PMID:23467088, PMID:31672973, PMID:36205477]
subset: cellxgene_subset
is_a: CL:0002078 ! meso-epithelial cell
intersection_of: CL:0002078 ! meso-epithelial cell
intersection_of: part_of UBERON:0001304 ! germinal epithelium of ovary
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0001304 ! germinal epithelium of ovary
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_2000064" xsd:string {name="ovarian surface epithelial cell on CELLxGENE CellGuide"}
creation_date: 2014-10-07T17:59:13Z
[Term]
id: CL:2000065
name: ovarian microvascular endothelial cell
def: "Any microvascular endothelial cell that is part of a female urethra." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7300
is_a: CL:1001320 ! urethra cell
is_a: CL:2000008 ! microvascular endothelial cell
intersection_of: CL:2000008 ! microvascular endothelial cell
intersection_of: part_of UBERON:0001334 ! female urethra
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0001334 ! female urethra
creation_date: 2014-10-07T18:18:01Z
[Term]
id: CL:2000066
name: cardiac ventricle fibroblast
def: "Any fibroblast that is part of a cardiac ventricle." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6310
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:0002548 ! fibroblast of cardiac tissue
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0002082 ! cardiac ventricle
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0002082 ! cardiac ventricle
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2014-10-07T18:35:38Z
[Term]
id: CL:2000067
name: cardiac atrium fibroblast
def: "Any fibroblast that is part of a cardiac atrium." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6320
subset: human_reference_atlas
is_a: CL:0002548 ! fibroblast of cardiac tissue
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0002081 ! cardiac atrium
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0002081 ! cardiac atrium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2014-10-07T18:36:54Z
[Term]
id: CL:2000068
name: pericardium fibroblast
def: "Any fibroblast that is part of a pericardium." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6430
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0002407 ! pericardium
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0002407 ! pericardium
creation_date: 2014-10-07T18:38:06Z
[Term]
id: CL:2000069
name: gallbladder fibroblast
def: "Any fibroblast that is part of a gallbladder." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=5430
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0002110 ! gallbladder
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0002110 ! gallbladder
creation_date: 2014-10-07T18:41:43Z
[Term]
id: CL:2000070
name: optic choroid fibroblast
def: "Any fibroblast that is part of a optic choroid." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6620
is_a: CL:0000005 ! neural crest derived fibroblast
is_a: CL:0000348 ! choroidal cell of the eye
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001776 ! optic choroid
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0001776 ! optic choroid
creation_date: 2014-10-07T18:50:43Z
[Term]
id: CL:2000071
name: mammary microvascular endothelial cell
def: "Any microvascular endothelial cell that is part of a breast." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7600
is_a: CL:2000008 ! microvascular endothelial cell
intersection_of: CL:2000008 ! microvascular endothelial cell
intersection_of: part_of UBERON:0000310 ! breast
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0000310 ! breast
creation_date: 2014-10-07T19:55:30Z
[Term]
id: CL:2000072
name: adipose microvascular endothelial cell
def: "Any microvascular endothelial cell that is part of a adipose tissue." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7200
is_a: CL:0002320 ! connective tissue cell
is_a: CL:2000008 ! microvascular endothelial cell
intersection_of: CL:2000008 ! microvascular endothelial cell
intersection_of: part_of UBERON:0001013 ! adipose tissue
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0001013 ! adipose tissue
creation_date: 2014-10-07T22:13:45Z
[Term]
id: CL:2000073
name: migratory cardiac neural crest cell
def: "Any migratory neural crest cell that is part of a cardiac neural crest." [GOC:TermGenie]
synonym: "cardiac neural crest cell" EXACT [PMID:33060096]
is_a: CL:0000333 ! migratory neural crest cell
intersection_of: CL:0000333 ! migratory neural crest cell
intersection_of: part_of UBERON:0000095 ! cardiac neural crest
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0000095 ! cardiac neural crest
creation_date: 2014-11-05T01:18:43Z
[Term]
id: CL:2000074
name: splenocyte
def: "Any leukocyte that is part of a spleen." [GOC:TermGenie]
comment: Splenocytes is a vague term that refers to any one of the different white blood cell types in the spleen. This name is seen many references as such and is not explained further, necessitating a need for this terminology.
is_a: CL:0000738 ! leukocyte
intersection_of: CL:0000738 ! leukocyte
intersection_of: part_of UBERON:0002106 ! spleen
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0002106 ! spleen
creation_date: 2014-11-05T01:26:50Z
[Term]
id: CL:2000075
name: anterior visceral endoderm cell
def: "Any endodermal cell that is part of a anterior visceral endoderm." [GOC:TermGenie]
is_a: CL:0000223 ! endodermal cell
intersection_of: CL:0000223 ! endodermal cell
intersection_of: part_of UBERON:0004044 ! anterior visceral endoderm
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0004044 ! anterior visceral endoderm
creation_date: 2014-11-05T01:34:13Z
[Term]
id: CL:2000076
name: hindlimb stylopod vein endothelial cell
def: "Any vein endothelial cell that is part of a hindlimb stylopod." [GOC:TermGenie]
is_a: CL:0002543 ! vein endothelial cell
intersection_of: CL:0002543 ! vein endothelial cell
intersection_of: part_of UBERON:0000376 ! hindlimb stylopod
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0000376 ! hindlimb stylopod
creation_date: 2014-12-02T18:40:47Z
[Term]
id: CL:2000077
name: skeletal muscle tissue of pectoralis major striated muscle cell
def: "Any striated muscle cell that is part of a skeletal muscle tissue of pectoralis major." [GOC:TermGenie]
is_a: CL:0000188 ! cell of skeletal muscle
is_a: CL:0000737 ! striated muscle cell
intersection_of: CL:0000737 ! striated muscle cell
intersection_of: part_of UBERON:0004510 ! skeletal muscle tissue of pectoralis major
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0004510 ! skeletal muscle tissue of pectoralis major
creation_date: 2014-12-02T18:48:17Z
[Term]
id: CL:2000078
name: placental pericyte
def: "Any pericyte cell that is part of a placenta." [GOC:TermGenie]
is_a: CL:0000669 ! pericyte
intersection_of: CL:0000669 ! pericyte
intersection_of: part_of UBERON:0001987 ! placenta
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0001987 ! placenta
creation_date: 2014-12-02T18:51:03Z
[Term]
id: CL:2000079
name: mesenchymal stem cell of femoral bone marrow
def: "Any mesenchymal stem cell of the bone marrow that is part of a femur." [GOC:TermGenie]
is_a: CL:0002540 ! mesenchymal stem cell of the bone marrow
intersection_of: CL:0002540 ! mesenchymal stem cell of the bone marrow
intersection_of: part_of UBERON:0000981 ! femur
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0000981 ! femur
creation_date: 2014-12-02T19:07:31Z
[Term]
id: CL:2000080
name: mesenchymal stem cell of abdominal adipose tissue
def: "Any mesenchymal stem cell of adipose tissue that is part of an abdomen." [GOC:TermGenie]
synonym: "mesenchymal stem cell of abdominal adipose" EXACT []
is_a: CL:0002570 ! mesenchymal stem cell of adipose tissue
intersection_of: CL:0002570 ! mesenchymal stem cell of adipose tissue
intersection_of: part_of UBERON:0000916 ! abdomen
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0000916 ! abdomen
creation_date: 2014-12-02T19:10:34Z
[Term]
id: CL:2000081
name: melanocyte of skin of face
def: "Any melanocyte of skin that is part of a skin of face." [GOC:TermGenie]
is_a: CL:1000458 ! melanocyte of skin
intersection_of: CL:1000458 ! melanocyte of skin
intersection_of: part_of UBERON:1000021 ! skin of face
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:1000021 ! skin of face
creation_date: 2014-12-02T19:10:40Z
[Term]
id: CL:2000083
name: hair follicle dermal papilla cell of scalp
def: "Any hair follicle dermal papilla cell that is part of a scalp." [GOC:TermGenie]
is_a: CL:0000346 ! hair follicle dermal papilla cell
intersection_of: CL:0000346 ! hair follicle dermal papilla cell
intersection_of: part_of UBERON:0000403 ! scalp
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0000403 ! scalp
creation_date: 2014-12-02T19:10:50Z
[Term]
id: CL:2000084
name: conjunctiva goblet cell
def: "A goblet cell that is part of the conjunctival epithelium, characterized by apical accumulation of mucin granules (containing MUC5AC in humans; Muc5ac/Muc5b in mice). These gel-forming mucins support tear film stability, ocular lubrication, and pathogen defence. The conjunctival goblet cell forms tight junctions with neighbouring epithelial cells via species-specific claudins (claudin-10 in humans, claudin-2 in mice) and regulates immune homeostasis by facilitating soluble antigen transport to dendritic cells through goblet cell-associated antigen passages (GAPs) (Barbosa et al., 2017). The transcription factor SPDEF is essential for its differentiation." [GOC:TermGenie, PMID:27091323, PMID:28475124, PMID:31734511]
subset: cellxgene_subset
synonym: "CGC" RELATED OMO:0003000 [PMID:31734511]
is_a: CL:0000160 ! goblet cell
is_a: CL:1000432 ! conjunctival epithelial cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0006763 ! epithelium of conjunctiva
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0006763 ! epithelium of conjunctiva
creation_date: 2014-12-02T19:28:38Z
[Term]
id: CL:2000085
name: mononuclear cell of umbilical cord
def: "Any mononuclear cell that is part of a umbilical cord." [GOC:TermGenie]
is_a: CL:0000349 ! extraembryonic cell
is_a: CL:0000842 ! mononuclear leukocyte
intersection_of: CL:0000842 ! mononuclear leukocyte
intersection_of: part_of UBERON:0002331 ! umbilical cord
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0002331 ! umbilical cord
creation_date: 2014-12-02T20:14:16Z
[Term]
id: CL:2000086
name: neocortex basket cell
def: "Any basket cell that is part of a neocortex." [GOC:TermGenie]
is_a: CL:0000118 ! basket cell
is_a: CL:0010011 ! cerebral cortex GABAergic interneuron
intersection_of: CL:0000118 ! basket cell
intersection_of: RO:0002100 UBERON:0001950 ! has soma location neocortex
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: RO:0002100 UBERON:0001950 ! has soma location neocortex
creation_date: 2014-12-24T00:37:19Z
[Term]
id: CL:2000087
name: dentate gyrus of hippocampal formation basket cell
def: "Any basket cell that is part of a dentate gyrus of hippocampal formation." [GOC:TermGenie]
is_a: CL:0000118 ! basket cell
is_a: CL:0010011 ! cerebral cortex GABAergic interneuron
is_a: CL:1001569 ! hippocampal interneuron
is_a: CL:4023062 ! dentate gyrus neuron
intersection_of: CL:0000118 ! basket cell
intersection_of: RO:0002100 UBERON:0001885 ! has soma location dentate gyrus of hippocampal formation
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: RO:0002100 UBERON:0001885 ! has soma location dentate gyrus of hippocampal formation
creation_date: 2014-12-24T00:37:24Z
[Term]
id: CL:2000088
name: Ammon's horn basket cell
def: "Any basket cell that is part of a Ammon's horn." [GOC:TermGenie]
is_a: CL:0000118 ! basket cell
is_a: CL:0010011 ! cerebral cortex GABAergic interneuron
is_a: CL:1001569 ! hippocampal interneuron
intersection_of: CL:0000118 ! basket cell
intersection_of: RO:0002100 UBERON:0001954 ! has soma location Ammon's horn
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: RO:0002100 UBERON:0001954 ! has soma location Ammon's horn
creation_date: 2014-12-24T00:37:30Z
[Term]
id: CL:2000089
name: dentate gyrus granule cell
def: "A granule cell that has soma location in the dentate gyrus cell layer of the hippocampal formation and has an elliptical cell body and characteristic cone-shaped tree of spiny apical dendrites. The branches extend throughout the molecular layer and the distal tips of the dendritic tree end just at the hippocampal fissure or at the ventricular surface. The dentate gyrus granule cell is the principal cell type of the dentate gyrus." [GOC:TermGenie, PMID:17765709]
comment: As far as can be determined, all dentate granule cells appear to project to CA3 and the axon trajectory is partially correlated with the position of the parent cell body. {xref="PMID:17765709"}
synonym: "dentate gyrus of hippocampal formation granule cell" EXACT []
is_a: CL:0001033 ! hippocampal granule cell
is_a: CL:4023062 ! dentate gyrus neuron
intersection_of: CL:0001033 ! hippocampal granule cell
intersection_of: RO:0002100 UBERON:0005381 ! has soma location dentate gyrus granule cell layer
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: RO:0002100 UBERON:0005381 ! has soma location dentate gyrus granule cell layer
creation_date: 2015-02-23T05:48:23Z
[Term]
id: CL:2000090
name: dentate gyrus of hippocampal formation stellate cell
def: "Any stellate cell that is part of a dentate gyrus of hippocampal formation." [GOC:TermGenie]
is_a: CL:0000122 ! stellate neuron
is_a: CL:4023062 ! dentate gyrus neuron
intersection_of: CL:0000122 ! stellate neuron
intersection_of: RO:0002100 UBERON:0001885 ! has soma location dentate gyrus of hippocampal formation
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: RO:0002100 UBERON:0001885 ! has soma location dentate gyrus of hippocampal formation
creation_date: 2015-02-23T05:48:40Z
[Term]
id: CL:2000091
name: endometrial microvascular endothelial cell
def: "Any microvascular endothelial cell that is part of a endometrial blood vessel." [GOC:TermGenie]
subset: human_reference_atlas
is_a: CL:0009095 ! endothelial cell of uterus
is_a: CL:2000008 ! microvascular endothelial cell
intersection_of: CL:2000008 ! microvascular endothelial cell
intersection_of: part_of UBERON:0015172 ! endometrial blood vessel
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0015172 ! endometrial blood vessel
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2015-03-31T21:02:36Z
[Term]
id: CL:2000092
name: hair follicular keratinocyte
def: "Any keratinocyte that is part of a hair follicle." [GOC:TermGenie]
subset: cellxgene_subset
is_a: CL:0002559 ! hair follicle cell
is_a: CL:4052061 ! epidermal keratinocyte
intersection_of: CL:0000312 ! keratinocyte
intersection_of: part_of UBERON:0002073 ! hair follicle
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0002073 ! hair follicle
creation_date: 2015-03-31T21:07:02Z
[Term]
id: CL:2000093
name: bronchus fibroblast of lung
def: "Any fibroblast of lung that is part of a bronchus." [GOC:TermGenie]
subset: cellxgene_subset
is_a: CL:0002553 ! fibroblast of lung
intersection_of: CL:0002553 ! fibroblast of lung
intersection_of: part_of UBERON:0002185 ! bronchus
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0002185 ! bronchus
creation_date: 2015-03-31T21:16:22Z
[Term]
id: CL:2000095
name: cord blood hematopoietic stem cell
def: "Any hematopoietic stem cell that is part of a umbilical cord blood." [GOC:TermGenie]
subset: cellxgene_subset
is_a: CL:0002246 ! peripheral blood stem cell
is_a: CL:0002352 ! gestational hematopoietic stem cell
intersection_of: CL:0000037 ! hematopoietic stem cell
intersection_of: part_of UBERON:0012168 ! umbilical cord blood
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0012168 ! umbilical cord blood
creation_date: 2015-05-26T18:58:34Z
[Term]
id: CL:2000096
name: fibroblast of the reticular layer of dermis
def: "A fibroblast of dermis that resides in the deep reticular layer, characterised by robust extracellular matrix production with high type I collagen deposition forming densely packed, organised fibrillar networks (Ghetti et al., 2018). This cell exhibits pro-fibrotic properties during wound healing, entering wounds early where it proliferates and deposits collagen to restore dermal architecture (Knoedler et al., 2023; McAndrews et al., 2022). It is distinguished from papillary dermal fibroblasts by expression of COL11A1, POSTN, and SPP1 in humans (Wu et al., 2022)." [GOC:TermGenie, PMID:29266210, PMID:35212000, PMID:36232952, PMID:37646029]
synonym: "reticular fibroblast" RELATED [PMID:29266210]
is_a: CL:0000151 ! secretory cell
is_a: CL:0002551 ! fibroblast of dermis
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001993 ! reticular layer of dermis
relationship: capable_of GO:0070278 ! extracellular matrix constituent secretion
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0001993 ! reticular layer of dermis
relationship: produces GO:0005584 ! collagen type I trimer
relationship: RO:0002292 PR:Q15063 ! expresses periostin (human)
creation_date: 2015-08-11T16:28:16Z
[Term]
id: CL:2000097
name: midbrain dopaminergic neuron
def: "Any dopaminergic neuron that is part of a midbrain." [GOC:TermGenie]
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:0000700 ! dopaminergic neuron
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000700 ! dopaminergic neuron
intersection_of: RO:0002100 UBERON:0001891 ! has soma location midbrain
relationship: dc-contributor http://www.wikidata.org/entity/Q35563349
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002100 UBERON:0001891 ! has soma location midbrain
creation_date: 2015-12-03T16:42:40Z
[Term]
id: CL:3000002
name: sympathetic noradrenergic neuron
def: "Sympathetic noradrenergic neuron." [GOC:CellBLAST, PMID:30096314]
subset: human_reference_atlas
is_a: CL:0008025 ! noradrenergic neuron
is_a: CL:0011103 ! sympathetic neuron
intersection_of: CL:0011103 ! sympathetic neuron
intersection_of: capable_of GO:0061533 ! norepinephrine secretion, neurotransmission
relationship: capable_of GO:0061533 ! norepinephrine secretion, neurotransmission
relationship: dc-contributor http://www.wikidata.org/entity/Q97529981
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2019-02-25T19:30:14Z
[Term]
id: CL:3000003
name: sympathetic cholinergic neuron
def: "A type of autonomic neuron that releases acetylcholine." [GOC:CellBLAST, PMID:30096314]
is_a: CL:0000108 ! cholinergic neuron
is_a: CL:0011103 ! sympathetic neuron
intersection_of: CL:0011103 ! sympathetic neuron
intersection_of: capable_of GO:0014055 ! acetylcholine secretion, neurotransmission
relationship: capable_of GO:0014055 ! acetylcholine secretion, neurotransmission
relationship: dc-contributor http://www.wikidata.org/entity/Q97529981
creation_date: 2019-02-25T19:32:20Z
[Term]
id: CL:3000004
name: peripheral sensory neuron
def: "A neuron type that is located in a peripheral nervous system and it transmits sensory information from the peripheral (PNS) to the central nervous system (CNS). A sensory neuron converts physical (light, sound, touch) or chemical (such as taste and smell) stimuli into an electrical signal through a process known as sensory transduction. The function of a sensory neuron is to carry informations from the external environment and internal body conditions to the central nervous system for further processing." [GOC:CellBLAST, https://www.britannica.com/science/sensory-neuron, https://www.ncbi.nlm.nih.gov/books/NBK539846/, PMID:30096314, PMID:31554486, PMID:35858549, Wikipedia:Sensory_neuron]
comment: Typically, a sensory neuron has a pseudounipolar morphology. {xref="Wikipedia:Sensory_neuron"}
is_a: CL:0000101 ! sensory neuron
is_a: CL:2000032 ! peripheral nervous system neuron
intersection_of: CL:2000032 ! peripheral nervous system neuron
intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
relationship: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
relationship: dc-contributor http://www.wikidata.org/entity/Q97529981
creation_date: 2019-02-25T19:34:33Z
[Term]
id: CL:4006000
name: fibroblast of breast
def: "A fibroblast that is part of the breast." []
subset: cellxgene_subset
synonym: "breast fibroblast" EXACT []
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0000310 ! breast
relationship: dc-contributor https://orcid.org/0000-0001-9897-3238
relationship: part_of UBERON:0000310 ! breast
[Term]
id: CL:4006001
name: fibroblast of skin of scalp
def: "A fibroblast that is part of the skin of scalp." []
synonym: "skin of scalp fibroblast" EXACT []
is_a: CL:0002620 ! skin fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:8300000 ! skin of scalp
relationship: dc-contributor https://orcid.org/0000-0001-9897-3238
relationship: part_of UBERON:8300000 ! skin of scalp
[Term]
id: CL:4023035
name: lateral ganglionic eminence derived neuron
def: "A neuron that is derived from a precursor cell in the lateral ganglion eminence." [wikipediaversioned:Ganglionic_eminence&oldid=1186824360]
subset: human_reference_atlas
synonym: "LGE-derived neuron" EXACT [PMID:10377350]
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: develops_from UBERON:0004025 ! lateral ganglionic eminence
relationship: develops_from UBERON:0004025 ! lateral ganglionic eminence
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dc-contributor "https://orcid.org/0000-0001-7258-9596" xsd:string
property_value: dc-contributor "https://orcid.org/0000-0002-7073-9172" xsd:string
[Term]
id: CL:4023038
name: L6b glutamatergic cortical neuron
def: "A glutamatergic neuron with a soma found in cortical layer 6b. They are transcriptomically related to corticothalamic-projecting neurons but have differential projections to the thalamus or anterior cingulate." [DOI:10.1101/2020.10.19.34312, https://cellxgene.cziscience.com/e/d01c9dff-abd1-4825-bf30-2eb2ba74597e.cxg/, PMID:30382198, PMID:37824655]
subset: BDS_subset
subset: cellxgene_subset
subset: human_reference_atlas
xref: ILX:0770163
is_a: CL:0000679 ! glutamatergic neuron
is_a: CL:0010012 ! cerebral cortex neuron
intersection_of: CL:0000679 ! glutamatergic neuron
intersection_of: RO:0002100 UBERON:8440003 ! has soma location cortical layer VIb
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002100 UBERON:8440003 ! has soma location cortical layer VIb
property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_4023038" xsd:string {name="L6b glutamatergic cortical neuron on CELLxGENE CellGuide"}
[Term]
id: CL:4023039
name: amygdala excitatory neuron
def: "Any neuron that has its soma located in some amygdala and is capable of some glutamate secretion, neurotransmission." [FBC:Autogenerated]
comment: An excitatory neuron that is located in the amygdala. {xref="DOI:10.1101/2022.10.12.511898"}
subset: human_reference_atlas
is_a: CL:0000679 ! glutamatergic neuron
is_a: CL:0012001 ! neuron of the forebrain
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0061535 ! glutamate secretion, neurotransmission
intersection_of: RO:0002100 UBERON:0001876 ! has soma location amygdala
relationship: capable_of GO:0061535 ! glutamate secretion, neurotransmission
relationship: dc-contributor http://orcid.org/0000-0001-7258-9596
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002100 UBERON:0001876 ! has soma location amygdala
[Term]
id: CL:4023057
name: cerebellar inhibitory GABAergic interneuron
def: "A GABAergic interneuron whose soma is located in the cerebellar cortex." [DOI:10.1101/2022.10.12.511898]
subset: human_reference_atlas
is_a: CL:0011005 ! GABAergic interneuron
is_a: CL:1001611 ! cerebellar neuron
intersection_of: CL:0011005 ! GABAergic interneuron
intersection_of: RO:0002100 UBERON:0002129 ! has soma location cerebellar cortex
relationship: dc-contributor http://orcid.org/0000-0001-7258-9596
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002100 UBERON:0002129 ! has soma location cerebellar cortex
[Term]
id: CL:4023059
name: committed oligodendrocyte precursor
def: "An oligodendrocyte precursor cell that is committed to differentiate." [PMID:32066987]
comment: COPs are distinct from OPCs in that the lack expression of Pdgfra and Cspg4 and come out as distinct clusters in transcriptomic profiling. This is the reason that this term is not modelled as a subclassOf OPC but instead linked using develops_from. {xref="PMID:27284195"}
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "COP" EXACT OMO:0003000 []
synonym: "differentiation-committed oligodendrocyte precursor" EXACT []
is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata)
relationship: dc-contributor http://orcid.org/0000-0001-7258-9596
relationship: develops_from CL:0002453 ! oligodendrocyte precursor cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:4023062
name: dentate gyrus neuron
def: "A neuron with its soma located in the dentate gyrus of the hippocampus." []
subset: human_reference_atlas
is_a: CL:0002608 ! hippocampal neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0001885 ! has soma location dentate gyrus of hippocampal formation
relationship: dc-contributor http://orcid.org/0000-0001-7258-9596
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002100 UBERON:0001885 ! has soma location dentate gyrus of hippocampal formation
[Term]
id: CL:4023063
name: medial ganglionic eminence derived interneuron
def: "An interneuron that is derived from the medial ganglionic eminence." [DOI:10.1101/2022.10.12.511898]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "MGE interneuron" EXACT []
is_a: CL:0000099 ! interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: develops_from UBERON:0004024 ! medial ganglionic eminence
relationship: dc-contributor http://orcid.org/0000-0001-7258-9596
relationship: develops_from UBERON:0004024 ! medial ganglionic eminence
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:4023064
name: caudal ganglionic eminence derived interneuron
def: "An interneuron that is derived from the caudal ganglionic eminence." [PMID:20130169, PMID:37824655, PMID:37824663]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "caudal ganglionic eminence derived GABAergic interneuron" EXACT [PMID:20130169]
synonym: "CGE interneuron" RELATED OMO:0003000 [PMID:20130169, PMID:37824663]
synonym: "CGE-derived cell" RELATED OMO:0003000 [PMID:27034423]
synonym: "CGE-derived GABAergic IN" RELATED OMO:0003000 [PMID:27034423]
synonym: "CGE-derived interneuron" RELATED OMO:0003000 [PMID:20130169, PMID:37824655]
is_a: CL:0010011 ! cerebral cortex GABAergic interneuron
is_a: CL:4042039 ! caudal ganglionic eminence derived neuron
intersection_of: CL:0000099 ! interneuron
intersection_of: develops_from UBERON:0004026 ! caudal ganglionic eminence
relationship: dc-contributor http://orcid.org/0000-0001-7258-9596
relationship: develops_from UBERON:0004026 ! caudal ganglionic eminence
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:4023068
name: thalamic excitatory neuron
def: "An excitatory neuron that has its soma located in the thalamic complex. This neuron type can be involved in a series of circuits related to sensory integration, motor integration, pain processing, social behaviour and reward response." [PMID:30083593, PMID:31196673, PMID:35278647, PMID:37163009, PMID:37824663, PMID:38739251]
comment: Abnormalities in glutametergic neurons of the thalamic complex are associated with pathologies such as schizophrenia, colorectal visceral pain and Parkinson's disease. {xref="PMID:11532718", xref="PMID:30083593", xref="PMID:38739251"}
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:0000679 ! glutamatergic neuron
is_a: CL:0012001 ! neuron of the forebrain
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0061535 ! glutamate secretion, neurotransmission
intersection_of: RO:0002100 UBERON:0010225 ! has soma location thalamic complex
relationship: capable_of GO:0061535 ! glutamate secretion, neurotransmission
relationship: dc-contributor http://orcid.org/0000-0001-7258-9596
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002100 UBERON:0010225 ! has soma location thalamic complex
[Term]
id: CL:4023069
name: medial ganglionic eminence derived GABAergic interneuron
def: "A GABAergic interneuron that develops from the medial ganglionic eminence and has migrated to the cerebral cortex." [PMID:12637172]
subset: cellxgene_subset
is_a: CL:0010011 ! cerebral cortex GABAergic interneuron
is_a: CL:4023063 ! medial ganglionic eminence derived interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission
intersection_of: develops_from UBERON:0004024 ! medial ganglionic eminence
intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
relationship: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: develops_from UBERON:0004024 ! medial ganglionic eminence
relationship: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
[Term]
id: CL:4023072
name: brain vascular cell
def: "A cell that is part of the brain vasculature." [DOI:10.1101/2022.10.12.511898]
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0008998 ! vasculature of brain
relationship: dc-contributor http://orcid.org/0000-0001-7258-9596
relationship: part_of UBERON:0008998 ! vasculature of brain
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:4023074
name: mammillary body neuron
def: "A neuron that has its soma located in the mammillary body." [DOI:10.1101/2022.10.12.511898]
subset: human_reference_atlas
is_a: CL:0012001 ! neuron of the forebrain
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0002206 ! has soma location mammillary body
relationship: dc-contributor http://orcid.org/0000-0001-7258-9596
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002100 UBERON:0002206 ! has soma location mammillary body
[Term]
id: CL:4023079
name: midbrain-derived inhibitory neuron
def: "A GABAergic inhibitory neuron that is derived from the midbrain." [DOI:10.1101/2022.10.12.511898]
subset: human_reference_atlas
is_a: CL:2000029 ! central nervous system neuron
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: CL:0000540 ! neuron
intersection_of: develops_from UBERON:0001891 ! midbrain
relationship: dc-contributor http://orcid.org/0000-0001-7258-9596
relationship: develops_from UBERON:0001891 ! midbrain
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:4023107
name: reticulospinal neuron
def: "A neuron with soma location in the reticular formation with axons that extend into the spinal cord such. Reticulospinal neuron activity can lead to a variety of motor behaviors." [PMID:29720934]
synonym: "RSN" EXACT [PMID:29720934]
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0002275 ! has soma location reticular formation
intersection_of: RO:0013001 UBERON:0002240 ! has synaptic IO in region spinal cord
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: RO:0002100 UBERON:0002275 ! has soma location reticular formation
relationship: RO:0013001 UBERON:0002240 ! has synaptic IO in region spinal cord
[Term]
id: CL:4023109
name: vasopressin-secreting magnocellular cell
def: "A magnocellular neurosecretory cell that is capable of producing and secreting vasopressin." [WikipediaVersioned:Magnocellular_neurosecretory_cell&oldid=1021059931]
is_a: CL:0000167 ! peptide hormone secreting cell
is_a: CL:0011003 ! magnocellular neurosecretory cell
intersection_of: CL:0011003 ! magnocellular neurosecretory cell
intersection_of: capable_of GO:0030103 ! vasopressin secretion
relationship: capable_of GO:0030103 ! vasopressin secretion
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
[Term]
id: CL:4023110
name: amygdala pyramidal neuron
def: "A pyramidal neuron with soma located in the amygdala." [PMID:1375860]
is_a: CL:0000598 ! pyramidal neuron
is_a: CL:0012001 ! neuron of the forebrain
intersection_of: CL:0000598 ! pyramidal neuron
intersection_of: RO:0002100 UBERON:0001876 ! has soma location amygdala
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: RO:0002100 UBERON:0001876 ! has soma location amygdala
[Term]
id: CL:4023111
name: cerebral cortex pyramidal neuron
def: "A pyramidal neuron with soma located in the cerebral cortex." [PMID:30715238]
subset: cellxgene_subset
is_a: CL:0000598 ! pyramidal neuron
is_a: CL:0010012 ! cerebral cortex neuron
intersection_of: CL:0000598 ! pyramidal neuron
intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
[Term]
id: CL:4023120
name: cochlea auditory hair cell
def: "An auditory hair cell found in the cochlea." [Wikipedia:Hair_cell]
subset: cellxgene_subset
synonym: "cochlear hair cell" EXACT []
xref: FMA:62364
is_a: CL:0000202 ! auditory hair cell
is_a: CL:0002374 ! ear hair cell
intersection_of: CL:0000202 ! auditory hair cell
intersection_of: part_of UBERON:0002227 ! spiral organ of cochlea
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: part_of UBERON:0002227 ! spiral organ of cochlea
[Term]
id: CL:4023154
name: myelinating glial cell
def: "A glial cell that myelinates axonal processes." [DOI:10.1007/3-540-29623-9_3240]
is_a: CL:0000125 ! glial cell
intersection_of: CL:0000125 ! glial cell
intersection_of: has_part GO:0043209 ! myelin sheath
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: has_part GO:0043209 ! myelin sheath
[Term]
id: CL:4023161
name: unipolar brush cell
def: "An excitatory glutamatergic interneuron found in the granular layer of the cerebellar cortex and also in the granule cell domain of the cochlear nucleus. Unipolar brush cells have a round or oval cell body with usually a single short dendrite that ends in a brush-like tuft of short dendrites unique to them known as dendrioles." [PMID:9193142, WikipediaVersioned:Unipolar_brush_cell&oldid=1045937026]
subset: cellxgene_subset
synonym: "neuronal brush cell" EXACT []
is_a: CL:0000099 ! interneuron
is_a: CL:0000679 ! glutamatergic neuron
relationship: dc-contributor http://orcid.org/0000-0001-7258-9596
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: has_part GO:0044293 ! dendriole
relationship: RO:0000053 PATO:0070025 ! has characteristic unipolar neuron morphology
relationship: RO:0002100 UBERON:0002028 ! has soma location hindbrain
[Term]
id: CL:4023168
name: somatosensory neuron
def: "A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli." [PMID:22865660]
is_a: CL:2000032 ! peripheral nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: part_of UBERON:0003942 ! somatosensory system
intersection_of: RO:0002100 UBERON:0000010 ! has soma location peripheral nervous system
relationship: dc-contributor http://orcid.org/0000-0001-7258-9596
relationship: part_of UBERON:0003942 ! somatosensory system
relationship: RO:0002100 UBERON:0000010 ! has soma location peripheral nervous system
[Term]
id: CL:4023187
name: koniocellular cell
def: "A neuron with a small cell body that is located in a koniocellular layer of the lateral geniculate nucleus (LGN)." [WikipediaVersioned:Lateral_geniculate_nucleus&oldid=1098375993]
comment: In adult monkeys, koniocellular cells can be distinguished from parvocellular and magnocellular of the LGN by their expression of calbindin, the alpha subunit of type II calmodulin-dependent protein kinase, and the gamma subunit of protein kinase C. {xref="PMID:10845061"}
synonym: "K cell" EXACT [PMID:10845061]
xref: NIFEXT:44
is_a: CL:0012001 ! neuron of the forebrain
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0013615 ! has soma location koniocellular layer of dorsal nucleus of lateral geniculate body
relationship: dc-contributor http://orcid.org/0000-0001-7258-9596
relationship: RO:0002100 UBERON:0013615 ! has soma location koniocellular layer of dorsal nucleus of lateral geniculate body
[Term]
id: CL:4028001
name: pulmonary capillary endothelial cell
def: "Any capillary endothelial cell that is part of a lung." []
subset: cellxgene_subset
synonym: "lung capillary endothelial cell" EXACT []
is_a: CL:0002144 ! capillary endothelial cell
is_a: CL:2000016 ! lung microvascular endothelial cell
intersection_of: CL:0002144 ! capillary endothelial cell
intersection_of: part_of UBERON:0002048 ! lung
relationship: dc-contributor https://orcid.org/0000-0002-3293-5463
relationship: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0016405 ! pulmonary capillary
creation_date: 2021-11-23T02:31:40Z
[Term]
id: CL:4030000
name: choroidal melanocyte
def: "A melanocyte located in the vascular uvea and involved in photoprotection, regulation of oxidative damage and immune responses." [http://orcid.org/0000-0002-0819-0473, PMID:31819095]
comment: Cellular functions and extracellular interactions of choroidal melanocytes are distinct to skin melanocytes. They might have both neuroectodermal as well as mesectodermal origins. {xref="PMID:34082079", xref="PMID:31819095"}
synonym: "uveal melanocyte" EXACT []
is_a: CL:0000148 ! melanocyte
intersection_of: CL:0000148 ! melanocyte
intersection_of: part_of UBERON:0001768 ! uvea
relationship: part_of UBERON:0001768 ! uvea
creation_date: 2022-01-20T12:59:06Z
[Term]
id: CL:4030001
name: stromal cell of thymus
def: "A stromal cell that is part of the thymus." [doi:10.1038/s41467-020-20082-7]
synonym: "thymic stromal cell" EXACT []
is_a: CL:0000499 ! stromal cell
intersection_of: CL:0000499 ! stromal cell
intersection_of: part_of UBERON:0002370 ! thymus
relationship: part_of UBERON:0002370 ! thymus
property_value: dcterms-date "2022-07-08T11:39:38Z" xsd:dateTime
[Term]
id: CL:4030008
name: pronephric podocyte
def: "A specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the pronephros." [PMID:10322630]
synonym: "pronephric glomerular visceral epithelial cell" EXACT [ZFA:0001673]
is_a: CL:0000653 ! podocyte
intersection_of: CL:0000653 ! podocyte
intersection_of: part_of UBERON:0002120 ! pronephros
relationship: dc-contributor https://orcid.org/0000-0002-2244-7917
relationship: part_of UBERON:0002120 ! pronephros
property_value: dcterms-date "2022-03-11T14:38:32Z" xsd:dateTime
[Term]
id: CL:4030009
name: epithelial cell of proximal tubule segment 1
def: "A brush border cell that is part of segment 1 (S1) of the proximal tubule epithelium, located in the renal cortex." [PMID:23799132, PMID:23897681, PMID:31249312]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "epithelial cell of segment 1 of proximal tubule" EXACT []
is_a: CL:1000838 ! kidney proximal convoluted tubule epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: has_part GO:0005903 ! brush border
intersection_of: part_of UBERON:0004196 ! proximal convoluted tubule segment 1
relationship: has_part GO:0005903 ! brush border
relationship: part_of UBERON:0004196 ! proximal convoluted tubule segment 1
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2022-05-10T13:14:00Z" xsd:dateTime
[Term]
id: CL:4030010
name: epithelial cell of proximal tubule segment 2
def: "A brush border cell that is part of segment 2 (S2) of the proximal tubule epithelium, located in the renal cortex. In addition to its reabsorptive functions, it is also specialized in the secretion of organic anions and cations, including para-aminohippurate." [PMID:23799132, PMID:23897681, PMID:31249312, PMID:31253652]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "epithelial cell of segment 2 of proximal tubule" EXACT []
is_a: CL:1000838 ! kidney proximal convoluted tubule epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: has_part GO:0005903 ! brush border
intersection_of: part_of UBERON:0004197 ! proximal convoluted tubule segment 2
relationship: has_part GO:0005903 ! brush border
relationship: part_of UBERON:0004197 ! proximal convoluted tubule segment 2
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2022-05-10T13:26:13Z" xsd:dateTime
[Term]
id: CL:4030011
name: epithelial cell of proximal tubule segment 3
def: "A brush border cell that is part of segment 3 (S3) of the proximal tubule epithelium, which extends from the medullary rays of the renal cortex into the outer medulla." [PMID:23799132, PMID:31249312]
comment: The epithelial cell of proximal tubule segment 3 operates under relatively hypoxic conditions and is particularly susceptible to ischemic injury. {xref="PMID:31249312"}
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "epithelial cell of segment 3 of proximal tubule" EXACT []
is_a: CL:0002307 ! brush border cell of the proximal tubule
is_a: CL:1000839 ! kidney proximal straight tubule epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: has_part GO:0005903 ! brush border
intersection_of: part_of UBERON:0001290 ! proximal straight tubule
relationship: has_part GO:0005903 ! brush border
relationship: part_of UBERON:0001290 ! proximal straight tubule
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2022-05-10T13:31:06Z" xsd:dateTime
[Term]
id: CL:4030012
name: kidney loop of Henle short descending thin limb epithelial cell
def: "Epithelial cell of the descending thin limb of the short loop (cortical) nephron limited to the outer medulla (mainly inner strip). It is known in some mammalian species that the short descending limb of the loop of Henle selectively expresses the serine protease Corin, the homeobox TF Uncx, and the urea channel Slc14a2." [PMID:33769951]
subset: human_reference_atlas
synonym: "epithelial cell of the descending thin limb of the short loop of Henle" EXACT []
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:1001111 ! kidney loop of Henle thin descending limb epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0005099 ! short descending thin limb
relationship: dc-contributor https://orcid.org/0000-0003-2804-127X
relationship: part_of UBERON:0005099 ! short descending thin limb
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2022-05-13T11:00:29Z" xsd:dateTime
[Term]
id: CL:4030016
name: epithelial cell of early distal convoluted tubule
def: "An epithelial cell located in the early distal convoluted tubule." [http://orcid.org/0000-0003-2804-127X, PMID:24855283]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "DCT1 cell" BROAD [PMID:24855283]
is_a: CL:1000849 ! kidney distal convoluted tubule epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0005101 ! early distal convoluted tubule
relationship: part_of UBERON:0005101 ! early distal convoluted tubule
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2022-06-21T12:47:48Z" xsd:dateTime
[Term]
id: CL:4030017
name: epithelial cell of late distal convoluted tubule
def: "An epithelial cell located in the late distal convoluted tubule." [http://orcid.org/0000-0003-2804-127X, PMID:24855283]
comment: Although mineralocorticoid receptors are expressed throughout the entire [distal convoluted tubule], the DCT2 is sensitive to the actions of aldosterone, because it expresses an enzyme called 11-β hydroxysteroid dehydrogenase 2 (11-βHSD2) {xref="PMID:24855283"}
subset: human_reference_atlas
synonym: "DCT2 cell" BROAD [PMID:24855283]
is_a: CL:1000849 ! kidney distal convoluted tubule epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0005102 ! late distal convoluted tubule
relationship: part_of UBERON:0005102 ! late distal convoluted tubule
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2022-06-21T13:51:46Z" xsd:dateTime
[Term]
id: CL:4030018
name: kidney connecting tubule principal cell
def: "A renal principal cell located in the connecting tubule." [http://orcid.org/0000-0003-2804-127X, PMID:27582101, PMID:31249312]
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:0005009 ! renal principal cell
is_a: CL:1000768 ! kidney connecting tubule epithelial cell
intersection_of: CL:0005009 ! renal principal cell
intersection_of: part_of UBERON:0005097 ! renal connecting tubule
relationship: part_of UBERON:0005097 ! renal connecting tubule
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2022-06-27T15:25:10Z" xsd:dateTime
[Term]
id: CL:4030022
name: renal medullary fibroblast
def: "A fibroblast that is located in the renal medulla interstitium." [https://doi.org/10.1101/2021.07.28.454201, PMID:10559635]
comment: It has been noted that inner medullary fibroblasts are involved in the regulation of water and electrolyte homeostasis. {xref="PMID:10559635"}
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "kidney medullary fibroblast" EXACT []
is_a: CL:1000682 ! kidney medulla interstitial cell
is_a: CL:1000692 ! kidney interstitial fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0005211 ! renal medulla interstitium
relationship: part_of UBERON:0005211 ! renal medulla interstitium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2022-07-05T12:13:40Z" xsd:dateTime
[Term]
id: CL:4030023
name: respiratory tract hillock cell
def: "A hillock cell that is located in respiratory epithelium. In some mammalian species, this cell type has been noted to express KRT13 and KRT4 and is postulated to play a role in squamous barrier function and immunomodulation." [https://orcid.org/0000-0001-7772-9578, PMID:30069044, PMID:32726565, PMID:33442032]
subset: cellxgene_subset
synonym: "hillock cell of respiratory tract" EXACT []
synonym: "respiratory hillock cell" EXACT []
is_a: CL:0002368 ! respiratory tract epithelial cell
is_a: CL:4030024 ! hillock cell
intersection_of: CL:4030024 ! hillock cell
intersection_of: part_of UBERON:0004802 ! respiratory tract epithelium
relationship: part_of UBERON:0004802 ! respiratory tract epithelium
property_value: dcterms-date "2022-06-06T08:31:09Z" xsd:dateTime
[Term]
id: CL:4030024
name: hillock cell
def: "An epithelial, transitional cell type between basal and secretory; located in stratified, non-ciliated structures (called hillocks) with high cell turnover in epithelium. In some mammalian species, this cell type has been noted to express KRT13 and is postulated to play a role in squamous barrier function and immunomodulation." [PMID:30069044]
is_a: CL:0000066 ! epithelial cell
property_value: dcterms-date "2022-06-24T14:52:24Z" xsd:dateTime
[Term]
id: CL:4030025
name: renal cortical fibroblast
def: "A fibroblast that is located in the renal cortical interstitium." [PMID:10559635]
comment: Renal cortical fibroblasts have key roles in mediating intercellular communication with neighboring/infiltrating cells and extracellular matrix and maintenance of renal tissue architecture. They additionally have an endocrine function in the production of epoetin. {xref="PMID:16230044"}
synonym: "kidney cortical fibroblast" EXACT []
is_a: CL:1000681 ! kidney cortex interstitial cell
is_a: CL:1000692 ! kidney interstitial fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0005270 ! renal cortex interstitium
relationship: part_of UBERON:0005270 ! renal cortex interstitium
property_value: dcterms-date "2022-07-05T15:50:17Z" xsd:dateTime
[Term]
id: CL:4030027
name: GABAergic amacrine cell
def: "An amacrine cell that uses GABA as a neurotransmitter." [https://doi.org/10.1016/j.cell.2020.08.013]
subset: cellxgene_subset
synonym: "amacrine cell, GABAergic" EXACT []
is_a: CL:0000561 ! amacrine cell
is_a: CL:0011005 ! GABAergic interneuron
intersection_of: CL:0000561 ! amacrine cell
intersection_of: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission
relationship: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission
property_value: dcterms-date "2022-10-17T12:35:11Z" xsd:dateTime
[Term]
id: CL:4030029
name: blood lymphocyte
def: "A lymphocyte located in blood." [https://orcid.org/0000-0001-9990-8331]
subset: blood_and_immune_upper_slim
is_a: CL:0000542 ! lymphocyte
is_a: CL:2000001 ! peripheral blood mononuclear cell
intersection_of: CL:0000542 ! lymphocyte
intersection_of: part_of UBERON:0000178 ! blood
relationship: part_of UBERON:0000178 ! blood
property_value: dcterms-date "2022-11-04T14:40:00Z" xsd:dateTime
[Term]
id: CL:4030031
name: interstitial cell
def: "Any cell that is located within the interstitium between the cells most prominent in defining a given tissue. \"Interstitial cell\" is a morphological term and refers to a variety of cells with differing origins and phenotypes." [PMID:24987007]
subset: cellxgene_subset
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0005169 ! interstitial tissue
relationship: part_of UBERON:0005169 ! interstitial tissue
property_value: dcterms-date "2022-11-30T14:35:08Z" xsd:dateTime
[Term]
id: CL:4030032
name: valve interstitial cell
def: "An interstitial cell that is part of a cardiac valve leaflet. Along with valve endothelial cells, a valve interstitial cell maintains tissue homeostasis for the function of cardiac valves through secreting biochemical signals, matrix proteins and matrix remodeling enzymes." [https://doi.org/10.1098/rsif.2017.0580, https://doi.org/10.1161/ATVBAHA.120.314789, https://doi.org/10.1161/JAHA.117.006339, https://doi.org/10.2353/ajpath.2007.070251, https://orcid.org/0000-0001-7655-4833, PMID:25311230]
comment: Activated valve interstitial cells undergo continual turn over into deactivated fibroblasts and other cell fates (such as apoptosis). {xref="PMID:25311230"}
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "cardiac valve interstitial cell" EXACT []
synonym: "valvular interstitial cell" EXACT [PMID:25311230]
synonym: "VIC" EXACT OMO:0003000 [PMID:25311230, PMID:30796046]
is_a: CL:0000151 ! secretory cell
is_a: CL:1000147 ! cardiac valve cell
is_a: CL:4030031 ! interstitial cell
intersection_of: CL:4030031 ! interstitial cell
intersection_of: part_of UBERON:0000946 ! cardiac valve
relationship: capable_of GO:0070278 ! extracellular matrix constituent secretion
relationship: part_of UBERON:0000946 ! cardiac valve
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2022-12-06T14:18:45Z" xsd:dateTime
[Term]
id: CL:4030033
name: valve endothelial cell
def: "An endothelial cell that lines a surface of a cardiac valve leaflet. Along with valve interstitial cells, a valve endothelial cell maintains tissue homeostasis for the function of cardiac valves through secreting biochemical signals, matrix proteins and matrix remodeling enzymes." [PMID:25311230]
comment: At least in some mammalian species, a valve endothelial cell expresses CD31. Valve endothelial cells can undergo an endothelial to mesenchymal transition to acquire a fibroblast or myofibroblast phenotype that leads to changes in the microenvironmental signals and facilitates tissue regeneration. {xref="PMID:25311230"}
subset: cellxgene_subset
synonym: "valvular endothelial cell" EXACT [PMID:25311230]
synonym: "VEC" EXACT OMO:0003000 [PMID:25311230, PMID:30796046]
is_a: CL:0010008 ! cardiac endothelial cell
is_a: CL:1000147 ! cardiac valve cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0000946 ! cardiac valve
relationship: part_of UBERON:0000946 ! cardiac valve
property_value: dcterms-date "2022-12-09T11:58:49Z" xsd:dateTime
[Term]
id: CL:4030034
name: respiratory tract multiciliated cell
def: "A multiciliated epithelial cell located in the respiratory tract epithelium, characterized by a columnar shape and motile cilia on its apical surface. This cell develops through a highly orchestrated process, transitioning from a basal progenitor via an intermediate deuterosomal cell stage that generates centrioles essential for ciliogenesis." [PMID:18757316, PMID:21364219, PMID:34044844, PMID:37834236]
subset: cellxgene_subset
synonym: "ciliated cell of the respiratory tract" EXACT []
synonym: "respiratory ciliated cell" EXACT []
synonym: "respiratory multiciliated cell" EXACT []
is_a: CL:0002368 ! respiratory tract epithelial cell
is_a: CL:0005012 ! multiciliated epithelial cell
intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell
intersection_of: has_part GO:0031514 ! motile cilium
intersection_of: part_of UBERON:0004802 ! respiratory tract epithelium
intersection_of: RO:0000053 PATO:0010007 ! has characteristic multiciliated
relationship: develops_from CL:4033044 ! deuterosomal cell
relationship: develops_from UBERON:0000025 ! tube
relationship: develops_from UBERON:0000065 ! respiratory tract
relationship: develops_from UBERON:0000072 ! proximo-distal subdivision of respiratory tract
relationship: develops_from UBERON:0000468 ! multicellular organism
relationship: develops_from UBERON:0001004 ! respiratory system
relationship: develops_from UBERON:0004802 ! respiratory tract epithelium
relationship: directly_develops_from CL:4033044 ! deuterosomal cell
relationship: has_part GO:0031514 ! motile cilium
relationship: part_of UBERON:0004802 ! respiratory tract epithelium
relationship: RO:0000053 PATO:0010007 ! has characteristic multiciliated
property_value: dcterms-date "2023-01-25T11:06:01Z" xsd:dateTime
[Term]
id: CL:4030035
name: dental pulp stem cell
def: "A dental pulp cell that possesses stem-cell-like qualities, including self-renewal capability and multi-lineage differentiation." [DOI:10.1177/154405910208100806, https://orcid.org/0000-0002-2825-0621]
synonym: "DPSC" EXACT OMO:0003000 []
is_a: CL:0000034 ! stem cell
is_a: CL:0002148 ! dental pulp cell
intersection_of: CL:0000034 ! stem cell
intersection_of: part_of UBERON:0001754 ! dental pulp
relationship: part_of UBERON:0001754 ! dental pulp
property_value: dcterms-date "2023-01-10T14:02:02Z" xsd:dateTime
[Term]
id: CL:4030066
name: ureteric bud cell
def: "An epithelial cell that is part of a ureteric bud. A ureteric bud cell has the potential to induce metanephric mesenchymal cells to proliferate and convert to epithelia that form renal tubules via: (1) the secretion of multiple diffusible growth factors that rescue renal progenitors from apoptosis and stimulate them to proliferate and (2) contact-dependent mechanisms that induce mesenchymal-epithelial conversion." [PMID:17133361, PMID:24183650, PMID:9374839]
subset: cellxgene_subset
synonym: "UB cell" RELATED OMO:0003000 [PMID:24183650]
is_a: CL:0000068 ! duct epithelial cell
is_a: CL:0002518 ! kidney epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0000084 ! ureteric bud
relationship: part_of UBERON:0000084 ! ureteric bud
relationship: participates_in GO:2001013 {xref="PMID:9374839"} ! epithelial cell proliferation involved in renal tubule morphogenesis
property_value: dc-contributor "https://orcid.org/0000-0002-1425-877X" xsd:string
property_value: dcterms-date "2023-10-13T11:22:42Z" xsd:dateTime
[Term]
id: CL:4033000
name: endothelial cell of venule of lymph node
def: "A(n) endothelial cell that is part of a(n) venule of lymph node." [PMID:28217126]
is_a: CL:1000414 ! endothelial cell of venule
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:8410041 ! venule of lymph node
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: part_of UBERON:8410041 ! venule of lymph node
[Term]
id: CL:4033001
name: endothelial cell of arteriole of lymph node
def: "A(n) endothelial cell that is part of a(n) arteriole of lymph node." [PMID:28217126]
is_a: CL:1000412 ! endothelial cell of arteriole
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:8410042 ! arteriole of lymph node
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: part_of UBERON:8410042 ! arteriole of lymph node
[Term]
id: CL:4033002
name: neuroendocrine cell of epithelium of crypt of Lieberkuhn
def: "A(n) neuroendocrine cell that is part of a(n) epithelium of crypt of Lieberkuhn." [PMID:31390635]
is_a: CL:0000150 ! glandular secretory epithelial cell
is_a: CL:0000165 ! neuroendocrine cell
is_a: CL:1001516 ! intestinal enteroendocrine cell
intersection_of: CL:0000165 ! neuroendocrine cell
intersection_of: part_of UBERON:0011184 ! epithelium of crypt of Lieberkuhn
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: part_of UBERON:0011184 ! epithelium of crypt of Lieberkuhn
[Term]
id: CL:4033003
name: myoepithelial cell of bronchus submucosal gland
def: "A(n) myoepithelial cell that is part of a(n) bronchus submucosal gland." [PMID:19996346, PMID:5487122]
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:0000185 ! myoepithelial cell
is_a: CL:0002328 ! bronchial epithelial cell
intersection_of: CL:0000185 ! myoepithelial cell
intersection_of: part_of UBERON:8410043 ! bronchus submucosal gland
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: part_of UBERON:8410043 ! bronchus submucosal gland
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:4033004
name: smooth muscle cell of taenia coli
def: "A(n) smooth muscle cell that is part of a(n) taenia coli." [PMID:10715339, PMID:22320805]
is_a: CL:1000279 ! smooth muscle cell of large intestine
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0012419 ! taenia coli
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: part_of UBERON:0001278 ! epithelium of large intestine
relationship: part_of UBERON:0012419 ! taenia coli
[Term]
id: CL:4033005
name: serous secreting cell of bronchus submucosal gland
def: "A(n) serous secreting cell that is part of a(n) bronchus submucosal gland." [PMID:5487122, PMID:9651178]
comment: The marker set PRR4, C6orf58 can identify the Human cell type serous secreting cell of bronchus submucosal gland in the lung with a confidence of 0.75 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"}
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:0000152 ! exocrine cell
is_a: CL:0019001 ! tracheobronchial serous cell
intersection_of: CL:0000313 ! serous secreting cell
intersection_of: part_of UBERON:8410043 ! bronchus submucosal gland
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: part_of UBERON:8410043 ! bronchus submucosal gland
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0015004 CLM:1000054 ! has characterizing marker set
[Term]
id: CL:4033006
name: endothelial cell of efferent lymphatic vessel
def: "A(n) endothelial cell that is part of a(n) efferent lymphatic vessel." [PMID:32094869]
is_a: CL:0002138 ! endothelial cell of lymphatic vessel
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0010397 ! efferent lymphatic vessel
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: part_of UBERON:0010397 ! efferent lymphatic vessel
[Term]
id: CL:4033007
name: brush cell of epithelium of lobar bronchus
def: "A(n) brush cell that is part of a(n) epithelium of lobar bronchus." [PMID:15817800]
subset: human_reference_atlas
is_a: CL:0000082 ! epithelial cell of lung
is_a: CL:0002208 ! brush cell of bronchus
intersection_of: CL:0002204 ! tuft cell
intersection_of: part_of UBERON:0002339 ! epithelium of lobar bronchus
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: part_of UBERON:0002339 ! epithelium of lobar bronchus
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:4033008
name: vein endothelial cell of respiratory system
def: "A(n) vein endothelial cell that is part of a(n) respiratory system." [PMID:34030460]
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:0002543 ! vein endothelial cell
intersection_of: CL:0002543 ! vein endothelial cell
intersection_of: part_of UBERON:0001004 ! respiratory system
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: part_of UBERON:0001004 ! respiratory system
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:4033009
name: goblet cell of epithelium of lobar bronchus
def: "A(n) goblet cell that is part of a(n) epithelium of lobar bronchus." [PMID:18757316]
subset: human_reference_atlas
is_a: CL:1000143 ! lung goblet cell
is_a: CL:1000312 ! bronchial goblet cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0002339 ! epithelium of lobar bronchus
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: part_of UBERON:0002339 ! epithelium of lobar bronchus
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:4033010
name: neuroendocrine cell of epithelium of lobar bronchus
def: "A(n) neuroendocrine cell that is part of a(n) epithelium of lobar bronchus." [PMID:26711336, PMID:33355253]
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:0000082 ! epithelial cell of lung
is_a: CL:0002328 ! bronchial epithelial cell
is_a: CL:0008055 ! respiratory tract secretory epithelial cell
is_a: CL:1000223 ! pulmonary neuroendocrine cell
intersection_of: CL:0000165 ! neuroendocrine cell
intersection_of: part_of UBERON:0002339 ! epithelium of lobar bronchus
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: part_of UBERON:0002339 ! epithelium of lobar bronchus
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:4033011
name: smooth muscle cell of large intestine smooth muscle circular layer
def: "A(n) smooth muscle cell that is part of a(n) large intestine smooth muscle circular layer." [PMID:24997029]
is_a: CL:1000279 ! smooth muscle cell of large intestine
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0012398 ! large intestine smooth muscle circular layer
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: part_of UBERON:0001278 ! epithelium of large intestine
relationship: part_of UBERON:0012398 ! large intestine smooth muscle circular layer
[Term]
id: CL:4033012
name: smooth muscle cell of large intestine smooth muscle longitudinal layer
def: "A(n) smooth muscle cell that is part of a(n) large intestine smooth muscle longitudinal layer." [PMID:24997029]
is_a: CL:1000279 ! smooth muscle cell of large intestine
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0012399 ! large intestine smooth muscle longitudinal layer
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: part_of UBERON:0001278 ! epithelium of large intestine
relationship: part_of UBERON:0012399 ! large intestine smooth muscle longitudinal layer
[Term]
id: CL:4033013
name: suprabasal keratinocyte
def: "A keratinocyte that resides in the epidermal suprabasal layer and expresses differentiation markers, including keratin 1 and keratin 10, in both humans and mice. In human interfollicular epidermis, this cell retains proliferative capacity and possesses retrodifferentiation potential, acquiring basal-like properties during wound healing or basement membrane contact." [https://www.proteinatlas.org/humanproteome/single+cell+type/squamous+epithelial+cells#suprabasalkeratinocytes, PMID:22375063, PMID:35883599, PMID:9520465]
subset: cellxgene_subset
is_a: CL:4052061 ! epidermal keratinocyte
is_a: CL:7770004 ! suprabasal cell
intersection_of: CL:0000312 ! keratinocyte
intersection_of: part_of UBERON:0010402 ! epidermis suprabasal layer
relationship: dc-contributor http://orcid.org/0000-0001-6677-8489
relationship: part_of UBERON:0010402 ! epidermis suprabasal layer
creation_date: 2023-02-02T11:17:04Z
[Term]
id: CL:4033015
name: retinal astrocyte
def: "A star-shaped glial cell that is part of some retina. This cell links neurons to blood vessels and may provide structural and physiological support to optic nerve head axons." [PMID:25236977, PMID:33796062]
comment: In response to elevated intraocular pressure, a retinal astrocyte may modulate extracellular matrix remodeling. In the human retina, a retinal astrocyte is GFAP-positive, SOD3-positive and GYPC-positive. {xref="PMID:33796062", xref="PMID:32555229"}
subset: cellxgene_subset
subset: eye_upper_slim
synonym: "retinal astroglia" RELATED OMO:0003004 [PMID:33796062]
is_a: CL:0000127 ! astrocyte
is_a: CL:0009004 ! retinal cell
intersection_of: CL:0000127 ! astrocyte
intersection_of: part_of UBERON:0000966 ! retina
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: part_of UBERON:0000966 ! retina
property_value: dcterms-date "2023-03-02T14:38:32Z" xsd:dateTime
[Term]
id: CL:4033017
name: bronchiolar smooth muscle cell
def: "A smooth muscle cell that is part of a bronchiole." [ISBN:9781260462982, PMID:15347627]
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:0019019 ! tracheobronchial smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0002186 ! bronchiole
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: dc-contributor https://orcid.org/0000-0002-9185-3994
relationship: part_of UBERON:0002186 ! bronchiole
relationship: part_of UBERON:0004515 ! smooth muscle tissue of bronchiole
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2023-03-16T09:38:17Z" xsd:dateTime
[Term]
id: CL:4033018
name: lung megakaryocyte
def: "A megakaryocyte that is resident in the lung connective tissue." [PMID:33351116]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "lung MKs" RELATED OMO:0003004 [PMID:33351116]
synonym: "lung resident megakaryocyte" EXACT [PMID:36524131]
synonym: "lung-resident megakaryocyte" EXACT [PMID:36524131]
synonym: "MKL" RELATED OMO:0003000 [PMID:36524131]
is_a: CL:0000556 ! megakaryocyte
is_a: CL:0002320 ! connective tissue cell
intersection_of: CL:0000556 ! megakaryocyte
intersection_of: part_of UBERON:0000114 ! lung connective tissue
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: dc-contributor https://orcid.org/0000-0002-9185-3994
relationship: part_of UBERON:0000114 ! lung connective tissue
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2023-03-16T11:31:23Z" xsd:dateTime
[Term]
id: CL:4033020
name: mucus secreting cell of trachea gland
def: "A mucus secreting cell that is part of a submucosal gland of the trachea." [PMID:18931053, PMID:29656943]
subset: human_reference_atlas
synonym: "tracheal submucosal gland mucous cell" EXACT [PMID:18931053]
is_a: CL:0000307 ! tracheal epithelial cell
is_a: CL:4033037 ! mucus secreting cell of tracheobronchial tree submucosal gland
intersection_of: CL:0000319 ! mucus secreting cell
intersection_of: part_of UBERON:0005203 ! trachea gland
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: dc-contributor https://orcid.org/0000-0002-9185-3994
relationship: part_of UBERON:0005203 ! trachea gland
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2023-03-16T13:03:13Z" xsd:dateTime
[Term]
id: CL:4033021
name: myoepithelial cell of trachea gland
def: "A myoepithelial cell that is part of a submucosal gland of the trachea." [PMID:29656943]
subset: human_reference_atlas
is_a: CL:0000185 ! myoepithelial cell
is_a: CL:0000307 ! tracheal epithelial cell
intersection_of: CL:0000185 ! myoepithelial cell
intersection_of: part_of UBERON:0005203 ! trachea gland
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: dc-contributor https://orcid.org/0000-0002-9185-3994
relationship: part_of UBERON:0005203 ! trachea gland
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2023-03-16T13:36:43Z" xsd:dateTime
[Term]
id: CL:4033022
name: mucus secreting cell of bronchus submucosal gland
def: "A mucus secreting cell of a submucosal gland of the bronchus." [PMID:19965983]
comment: The marker set BPIFB2 can identify the Human cell type mucus secreting cell of bronchus submucosal gland in the lung with a confidence of 0.93 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"}
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "bronchial gland mucous cell" EXACT [PMID:5487122]
is_a: CL:0002328 ! bronchial epithelial cell
is_a: CL:4033037 ! mucus secreting cell of tracheobronchial tree submucosal gland
intersection_of: CL:0000319 ! mucus secreting cell
intersection_of: part_of UBERON:8410043 ! bronchus submucosal gland
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: dc-contributor https://orcid.org/0000-0002-9185-3994
relationship: part_of UBERON:8410043 ! bronchus submucosal gland
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0015004 CLM:1000053 ! has characterizing marker set
property_value: dcterms-date "2023-03-16T15:12:52Z" xsd:dateTime
[Term]
id: CL:4033025
name: perichondrial fibroblast
def: "A fibroblast that is part of the fibrous layer of the perichondrium. This cell is responsible for collagen fiber production." [wikipedia:Perichondrium]
subset: human_reference_atlas
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0008305 ! outer fibrous layer of perichondrium
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: dc-contributor https://orcid.org/0000-0002-9185-3994
relationship: part_of UBERON:0008305 ! outer fibrous layer of perichondrium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2023-03-16T16:12:50Z" xsd:dateTime
[Term]
id: CL:4033026
name: lung perichondrial fibroblast
def: "A perichondrial fibroblast that is part of the lung." [PMID:36543915]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "PC-fibro" RELATED OMO:0003000 [PMID:36543915]
is_a: CL:0002553 ! fibroblast of lung
is_a: CL:4033025 ! perichondrial fibroblast
intersection_of: CL:4033025 ! perichondrial fibroblast
intersection_of: part_of UBERON:0002048 ! lung
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: dc-contributor https://orcid.org/0000-0002-9185-3994
relationship: part_of UBERON:0002048 ! lung
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2023-03-16T16:15:39Z" xsd:dateTime
[Term]
id: CL:4033037
name: mucus secreting cell of tracheobronchial tree submucosal gland
def: "A mucus secreting cell of a submucosal gland of the tracheobronchial tree." [PMID:30864819]
subset: cellxgene_subset
is_a: CL:0000150 ! glandular secretory epithelial cell
is_a: CL:0000152 ! exocrine cell
is_a: CL:0000319 ! mucus secreting cell
is_a: CL:0002202 ! epithelial cell of tracheobronchial tree
is_a: CL:0008055 ! respiratory tract secretory epithelial cell
intersection_of: CL:0000319 ! mucus secreting cell
intersection_of: part_of UBERON:0007196 ! tracheobronchial tree
intersection_of: part_of UBERON:8410077 ! airway submucosal gland
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: part_of UBERON:0007196 ! tracheobronchial tree
relationship: part_of UBERON:8410077 ! airway submucosal gland
property_value: dcterms-date "2023-04-20T10:55:50Z" xsd:dateTime
[Term]
id: CL:4033044
name: deuterosomal cell
def: "An epithelial cell part of respiratory tract epithelium that is a precursor of a multi-ciliated cell. This cell actively amplifies centrioles, a required step for multiciliogenesis." [PMID:31558434, PMID:331922198, PMID:36883528, PMID:37291214]
comment: In humans, deuterosomal cells have been noted to have enriched expression of the following: PLK4, FOXJ1, DEUP1, FOXN4, YPEL1, HES6 and CDC20B. Deuterosomal cells were termed after deuterosomes, the platforms of active centriole amplification. {xref="PMID:31558434", xref="PMID:36883528", xref="PMID:331922198"}
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:0002368 ! respiratory tract epithelial cell
relationship: capable_of GO:0098535 ! de novo centriole assembly involved in multi-ciliated epithelial cell differentiation
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: dc-contributor https://orcid.org/0000-0002-9185-3994
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2023-06-20T10:27:17Z" xsd:dateTime
[Term]
id: CL:4033049
name: taste receptor cell of tongue
def: "A taste receptor cell that is part of a taste bud of a tongue." [DOI:10.1111/j.1096-3642.1981.tb01137.x, http://www.nejohnston.org/Birds/documents/AvianTongues_Johnston.pdf, PMID:10052456, PMID:28655883]
synonym: "gustatory cell of tongue" RELATED [DOI:10.1016/s0022-5320(69)80043-2]
is_a: CL:0000209 ! taste receptor cell
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000209 ! taste receptor cell
intersection_of: part_of UBERON:0014451 ! tongue taste bud
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: part_of UBERON:0014451 ! tongue taste bud
property_value: dcterms-date "2023-05-03T07:59:58Z" xsd:dateTime
[Term]
id: CL:4033050
name: catecholaminergic neuron
def: "A neuron that releases catecholamine as a neurotransmitter." [ISBN:0521442516, PMID:12094209]
comment: Frequently used when describing the developing nervous system in zebrafish. A catecholaminergic neuron expresses tyrosine hydroxylase (TH), tyrosine hydroxylase 2 (TH2), aromatic amino acid decarboxylase (AADC), dopamine b-hydroxylase (DBH), and phenylethanolamine-N-methyl transferase (PEMT), which are enzymes necessary for catecholamine synthesis. {xref="https://orcid.org/0000-0002-2244-7917", xref="PMID:12128258", xref="PMID:10191060", xref="PMID:34880760"}
subset: human_reference_atlas
is_a: CL:0000151 ! secretory cell
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0160043 ! catecholamine secretion, neurotransmission
relationship: capable_of GO:0160043 ! catecholamine secretion, neurotransmission
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2023-05-18T12:07:45Z" xsd:dateTime
[Term]
id: CL:4033054
name: perivascular cell
def: "A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics." [PMID:24928499, PMID:27889329]
subset: cellxgene_subset
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: adjacent_to UBERON:0002049 ! vasculature
relationship: adjacent_to UBERON:0002049 ! vasculature
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
property_value: dcterms-date "2023-08-22T13:40:28Z" xsd:dateTime
[Term]
id: CL:4033055
name: airway submucosal gland duct multiciliated cell
def: "A multi-ciliated epithelial cell located in ciliated duct of an airway submucosal gland, characterized by a columnar shape and motile cilia on its apical surface." [PMID:17707699, PMID:30864819]
subset: human_reference_atlas
synonym: "airway submucosal gland duct ciliated cell" EXACT []
is_a: CL:0000068 ! duct epithelial cell
is_a: CL:0005012 ! multiciliated epithelial cell
intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell
intersection_of: has_part GO:0031514 ! motile cilium
intersection_of: part_of UBERON:8410077 ! airway submucosal gland
intersection_of: part_of UBERON:8600014 ! submucosal gland ciliated duct
intersection_of: RO:0000053 PATO:0010007 ! has characteristic multiciliated
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: dc-contributor https://orcid.org/0000-0002-9185-3994
relationship: has_part GO:0031514 ! motile cilium
relationship: part_of UBERON:8410077 ! airway submucosal gland
relationship: part_of UBERON:8600014 ! submucosal gland ciliated duct
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0000053 PATO:0010007 ! has characteristic multiciliated
property_value: dcterms-date "2023-09-08T10:32:27Z" xsd:dateTime
[Term]
id: CL:4033057
name: luminal adaptive secretory precursor cell of mammary gland
def: "A luminal epithelial cell of the mammary gland that can proliferate and has the potential to differentiate into a lactocyte during pregnancy. In humans, a luminal adaptive secretory precursor cell can be identified by high levels of the markers EpCAM and CD49f, and in mice it can be identified by low levels of CD29 and high levels of CD14, Kit, CD61, and Tspan8." [https://nrs.harvard.edu/URN-3\:HUL.INSTREPOS\:37368328, https://orcid.org/0000-0001-6677-8489, PMID:19648928, PMID:35617956]
subset: cellxgene_subset
synonym: "alveolar cell" BROAD [PMID:35617956]
synonym: "alveolar progenitor" BROAD [PMID:26390871]
synonym: "AP" RELATED OMO:0003000 [https://nrs.harvard.edu/URN-3\:HUL.INSTREPOS\:37368328]
synonym: "AV" RELATED OMO:0003000 [PMID:35617956]
synonym: "ER-negative luminal alveolar progenitor" EXACT [https://nrs.harvard.edu/URN-3\:HUL.INSTREPOS\:37368328]
synonym: "LASP" RELATED OMO:0003000 [https://orcid.org/0000-0001-6677-8489]
synonym: "LP" RELATED OMO:0003000 [doi:10.1101/2023.04.21.537845]
synonym: "luminal progenitor" BROAD [doi:10.1101/2023.04.21.537845]
synonym: "luminal progenitor cell" BROAD [PMID:20346151]
synonym: "luminal secretory cell" BROAD [PMID:37380767]
synonym: "LumSec" RELATED OMO:0003000 [PMID:37380767]
is_a: CL:0002326 ! luminal epithelial cell of mammary gland
is_a: CL:0011026 ! progenitor cell
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: dc-contributor https://orcid.org/0000-0003-4969-670X
property_value: dcterms-date "2023-10-13T13:02:55Z" xsd:dateTime
[Term]
id: CL:4033061
name: endothelial cell of central vein of liver
def: "An endothelial cell that is part of a central vein of liver." [PMID:28287163]
synonym: "endothelial cell of central vein" BROAD [PMID:28287163]
is_a: CL:0002543 ! vein endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0006841 ! central vein of liver
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: part_of UBERON:0006841 ! central vein of liver
[Term]
id: CL:4033064
name: uterine resident macrophage
def: "A tissue-resident macrophage that is part of the uterus." [PMID:36113384]
comment: Uterine macrophages are reported to be evenly distributed throughout the endometrial stroma but with aggregations observed close to the lumen of superficial secretory glands. {xref="PMID:36113384"}
subset: human_reference_atlas
synonym: "uterine macrophage" BROAD [PMID:36113384]
is_a: CL:0000864 ! tissue-resident macrophage
intersection_of: CL:0000864 ! tissue-resident macrophage
intersection_of: part_of UBERON:0000995 ! uterus
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: part_of UBERON:0000995 ! uterus
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2024-01-08T16:05:09Z" xsd:dateTime
[Term]
id: CL:4033066
name: pre-granulosa cell
def: "A supporting cell that is part of the ovary and differentiates into a granulosa cell. A pre-granulosa cell develops from an early supporting gonadal cell by repressing testis determination, which can then proliferate to form primordial follicles." [PMID:17639032, PMID:32759216, PMID:33970370, PMID:38178246]
synonym: "ovarian pregranulosa cell" EXACT [PMID:32759216]
synonym: "PG cell" RELATED OMO:0003000 [PMID:32759216]
synonym: "pregranulosa cell" EXACT [PMID:17639032, PMID:32759216]
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000630 ! supporting cell
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: dc-contributor https://orcid.org/0000-0001-7655-4833
relationship: develops_into CL:4033083 ! squamous granulosa cell
relationship: part_of UBERON:0000992 ! ovary
relationship: RO:0002210 CL:4033083 ! directly develops into squamous granulosa cell
property_value: dcterms-date "2024-06-07T12:04:57Z" xsd:dateTime
[Term]
id: CL:4033083
name: squamous granulosa cell
def: "A granulosa cell that has a squamous morphology and form a single layer around the oocyte in primordial follicles. This cell develops directly into a cuboidal granulosa cell during the primordial-to-primary follicle transition." [PMID:28892263]
comment: Often in literature squamous granulosa cell and pre-granulosa cell are used as synonyms. However, this term only makes reference to the quiescent granulosa cells that surround the primordial ovarian follicle, while a pre-granulosa cell proliferates to form the primordial follicle (and thus cells become the squamous granulosa cells). {xref="https://orcid.org/0000-0001-6677-8489"}
synonym: "flattened granulosa cell" EXACT [PMID:22402964]
synonym: "pre-granulosa cell" RELATED [PMID:33914868]
synonym: "squamous GC" RELATED OMO:0003000 [PMID:33914868]
is_a: CL:0000501 ! granulosa cell
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: develops_from UBERON:0000474 ! female reproductive system
relationship: develops_from UBERON:0000992 ! ovary
relationship: develops_from UBERON:0003100 ! female organism
relationship: develops_into CL:4033084 ! cuboidal granulosa cell
relationship: directly_develops_from CL:4033066 ! pre-granulosa cell
relationship: part_of UBERON:0003981 ! primordial ovarian follicle
relationship: RO:0002210 CL:4033084 ! directly develops into cuboidal granulosa cell
property_value: dcterms-date "2024-09-24T13:13:24Z" xsd:dateTime
[Term]
id: CL:4033084
name: cuboidal granulosa cell
def: "A granulosa cell that has a cuboidal morphology and develops from squamous granulosa cell during the transition between primordial follicle to primary follicle. Cuboidal granulosa cells proliferate to form a second layer within secondary follicles." [PMID:28892263]
synonym: "columnar GC" RELATED OMO:0003000 [PMID:19001500]
synonym: "columnar granulosa cell" EXACT [PMID:19001500]
synonym: "cuboidal epithelial granulosa cell" EXACT [PMID:31849844]
synonym: "cuboidal GC" RELATED OMO:0003000 [PMID:33914868]
is_a: CL:0000501 ! granulosa cell
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: develops_from CL:4033083 ! squamous granulosa cell
relationship: develops_from UBERON:0003981 ! primordial ovarian follicle
relationship: directly_develops_from CL:4033083 ! squamous granulosa cell
property_value: dcterms-date "2024-09-24T13:14:57Z" xsd:dateTime
[Term]
id: CL:4033087
name: placental resident macrophage
def: "A tissue-resident macrophage that is part of the placenta. This cell helps preventing immunological rejection of the fetus by modulating the immune environment. A placental resident macrophage has high plasticity to adapt to the changing needs of each phase of pregnancy." [PMID:39007150]
synonym: "placental macrophage" BROAD [PMID:39007150]
is_a: CL:0000864 ! tissue-resident macrophage
intersection_of: CL:0000864 ! tissue-resident macrophage
intersection_of: part_of UBERON:0001987 ! placenta
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: dc-contributor https://orcid.org/0000-0001-7655-4833
relationship: part_of UBERON:0001987 ! placenta
property_value: dcterms-date "2024-10-31T10:24:21Z" xsd:dateTime
[Term]
id: CL:4033093
name: limbal epithelial stem cell of cornea
def: "A stem cell that is part of the corneo-scleral limbus. This cell type resides at the basal layer of the epithelium and has a small size and high nuclear to cytoplasmatic ratio (Secker and Daniels, 2009). A limbal stem cell is responsible for corneal epithelial renewal and repair (Li et al., 2023), and to help maintain a clear corneal surface by preventing conjunctival epithelial cells from migrating onto the cornea (Wang et al., 2023)." [PMID:20614614, PMID:29105366, PMID:36983561, PMID:37768272]
synonym: "LESC" RELATED OMO:0003000 [PMID:20614614]
synonym: "limbal epithelial stem cell" EXACT [PMID:20614614]
synonym: "limbal stem cell" EXACT [PMID:17562792]
synonym: "LSC" RELATED OMO:0003000 [PMID:36983561]
is_a: CL:0000036 ! epithelial fate stem cell
intersection_of: CL:0000034 ! stem cell
intersection_of: part_of UBERON:0006761 ! corneo-scleral junction
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: dc-contributor https://orcid.org/0000-0001-7655-4833
relationship: develops_into CL:0000575 ! corneal epithelial cell
relationship: part_of UBERON:0000482 ! basal lamina of epithelium
relationship: part_of UBERON:0006761 ! corneo-scleral junction
property_value: dcterms-date "2024-12-11T13:59:19Z" xsd:dateTime
[Term]
id: CL:4033097
name: Schlemm's canal endothelial cell
def: "A specialised endothelial cell that is part of the canal of Schlemm. This cell type shares characteristics and expresses markers of both blood and lymphatic endothelial cells (Kizhatil et al., 2014) and regulates aqueous humor outflow resistance by modulating pore formation and responding to mechanical strain (Stamer et al., 2015)." [PMID:25051267, PMID:25223880]
synonym: "SC endothelial cell" RELATED OMO:0003000 [PMID:25051267]
synonym: "SEC" RELATED OMO:0003000 [PMID:25051267]
is_a: CL:0002543 ! vein endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0004029 ! canal of Schlemm
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: part_of UBERON:0004029 ! canal of Schlemm
property_value: dcterms-date "2025-06-16T13:55:29Z" xsd:dateTime
[Term]
id: CL:4040002
name: enteroglial cell
def: "Glial cell that provides support to the enteric nervous system. It is involved in enteric neurotransmission, in maintaining the integrity of the mucosal barrier of the gut and serves as a link between the nervous and immune systems of the gut. In enteric nerve strands, glial processes ensheath multiaxonal bundles which distinguishes enteric glia from all other peripheral glia. Ultrastructurally, the most conspicuous trait of an enteroglial cell is the presence of 10 nm filaments, which criss-cross the cell body, form axial bundles in the processes and appear to firmly anchor the cells to the ganglionic surfaces. Similar to astrocytes, their main constituent is glial fibrillary acidic protein (GFAP)." [PMID:16336493, PMID:17483847, PMID:25975510]
subset: cellxgene_subset
synonym: "enteric glia" RELATED OMO:0003004 [PMID:11169131]
synonym: "enteric glial cell" EXACT [PMID:11169131, PMID:25170211]
is_a: CL:0000125 ! glial cell
intersection_of: CL:0000125 ! glial cell
intersection_of: part_of UBERON:0002005 ! enteric nervous system
relationship: dc-contributor https://orcid.org/0000-0002-0819-0473
relationship: part_of UBERON:0002005 ! enteric nervous system
relationship: RO:0002292 PR:000007939 ! expresses glial fibrillary acidic protein
property_value: dcterms-date "2023-04-03T15:15:40Z" xsd:dateTime
[Term]
id: CL:4040003
name: fetal pre-type II pulmonary alveolar epithelial cell
def: "Precursor of type II pneumocyte. These cells do not have lamellar bodies, which are a marker of type II pneumocyte maturity." [PMID:1316350]
comment: According to PMID:1316350 this cell type does not yet produce surfactant. According to PMID:9109447 and PMID:12114192 this cell type produces low levels of surfactant that can be increased by administration of very low-density lipoproteins. This cell type is of medical relevance, as a central feature of the fetal respiratory distress syndrome seems to be the presence in the lung of abundant pre-type II alveolar epithelial cells (PMID:1316350).
subset: cellxgene_subset
synonym: "fetal alveolar pre-type II epithelial cell" EXACT [PMID:9624168]
synonym: "fetal pre-type 2 pneumocyte" EXACT [https://orcid.org/0000-0002-0819-0473]
synonym: "fetal pre-type II alveolar epithelial cell" EXACT [PMID:12114192]
synonym: "fetal pre-type II pneumocyte" EXACT []
is_a: CL:0000322 ! pulmonary alveolar epithelial cell
relationship: dc-contributor https://orcid.org/0000-0002-0819-0473
property_value: dcterms-date "2023-06-02T09:19:31Z" xsd:dateTime
[Term]
id: CL:4040004
name: mesenchymal stem cell of orbital adipose tissue
def: "Any mesenchymal stem cell of adipose tissue that is part of an orbital region." [https://orcid.org/0000-0002-0819-0473]
synonym: "OAMSC" EXACT [PMID:31377878]
synonym: "orbital adipose-derived mesenchymal stem cell" EXACT [PMID:31377878]
synonym: "Orbital ASCs" EXACT [PMID:30210548]
is_a: CL:0002570 ! mesenchymal stem cell of adipose tissue
intersection_of: CL:0002570 ! mesenchymal stem cell of adipose tissue
intersection_of: part_of UBERON:0004088 ! orbital region
relationship: dc-contributor https://orcid.org/0000-0002-0819-0473
relationship: part_of UBERON:0004088 ! orbital region
property_value: dcterms-date "2023-09-18T10:43:00Z" xsd:dateTime
[Term]
id: CL:4042003
name: border associated macrophage
def: "A central nervous system macrophage that is part of a choroid plexus, a meninx and a perivascular space. A border associated macrophage interacts with various components of the CNS vasculature and meninges, it participates in immune surveillance and in the regulation of the blood brain barrier." [PMID:37232741, PMID:37626977]
comment: In humans, a border associate macrophage expresses CD45 and CD11B. This cell is also known to have the following molecular signature: CD206, CD38, LYVE1, CD163, CD169. {xref="PMID:29426702", xref="PMID:37232741"}
synonym: "BAM" RELATED OMO:0003000 [PMID:36945367]
synonym: "CAM" RELATED OMO:0003000 [PMID:33556248]
synonym: "CNS-associated macrophage" RELATED [PMID:37232741]
is_a: CL:0000878 ! central nervous system macrophage
relationship: dc-contributor https://orcid.org/0000-0002-0098-8958
property_value: dcterms-date "2024-03-26T16:39:56Z" xsd:dateTime
[Term]
id: CL:4042035
name: molecular layer interneuron
def: "A type of cerebellar inhibitory GABAergic interneuron that is located in the molecular layer of the cerebellum. This cell type inhibits Purkinje cells and other molecular layer interneurons. This interneuron plays a crucial role in regulating cerebellar output through feedforward inhibition and is characterized by its fast-spiking properties." [PMID:30742002, PMID:33075461, PMID:34616064, PMID:38692278]
synonym: "MLI" RELATED [PMID:33075461] {RELATED="OMO:0003000"}
is_a: CL:4023057 ! cerebellar inhibitory GABAergic interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission
intersection_of: RO:0002100 UBERON:0002974 ! has soma location molecular layer of cerebellar cortex
relationship: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission
relationship: dc-contributor https://orcid.org/0000-0002-0098-8958
relationship: RO:0002100 UBERON:0002974 ! has soma location molecular layer of cerebellar cortex
property_value: dcterms-date "2024-10-31T15:55:31Z" xsd:dateTime
[Term]
id: CL:4042039
name: caudal ganglionic eminence derived neuron
def: "A neuron of the central nervous system that develops from a caudal ganglionic eminence." [https://www.ncbi.nlm.nih.gov/books/NBK98190/, PMID:12593982, PMID:12637172, PMID:20130169]
comment: Neurons derived from the caudal ganglionic eminence consist mostly of neurons populating the cortical layers of the brain and some subcortical areas such as the globus pallidus, the striatus and the hippocampus. Amongst neurons derived from the caudal ganglionic eminence there are cortical GABAergic neurons such as Pax6, Lamp5, VIP, sncg, GABAergic; in the hippocampus, mossy fibers, pyramidal neurons, granule neurons and interneurons; in the striatum and globus pallidus, medium spiny projection neurons. {xref="https://www.ncbi.nlm.nih.gov/books/NBK98190/", xref="PMID:12637172", xref="PMID:12593982", xref="PMID:20130169"}
is_a: CL:2000029 ! central nervous system neuron
relationship: dc-contributor https://orcid.org/0000-0002-0098-8958
relationship: develops_from UBERON:0004026 ! caudal ganglionic eminence
property_value: dcterms-date "2024-11-14T11:27:25Z" xsd:dateTime
[Term]
id: CL:4047017
name: transit amplifying cell of gut
def: "A transit amplifying cell of the gut epithelium, located in the wall of the intestinal crypt, just above intestinal stem cells from which they derive. These are rapidly dividing cells, capable of multiple rounds of division before differentiating into the various cell types of the gut epithelium (enterocyte, goblet, eneterodendocrine, paneth cells)." [PMID:20683682, PMID:33195268, PMID:34497389]
synonym: "TA cell" RELATED [PMID:20683682]
synonym: "transit-amplifying cell" BROAD [PMID:24813615]
is_a: CL:0002563 ! intestinal epithelial cell
is_a: CL:0009010 ! transit amplifying cell
intersection_of: CL:0009010 ! transit amplifying cell
intersection_of: part_of UBERON:0013740 ! wall of crypt of Lieberkuhn
relationship: dc-contributor https://orcid.org/0009-0005-7919-4905
relationship: develops_from CL:0002250 ! intestinal crypt stem cell
relationship: develops_from UBERON:0000160 ! intestine
relationship: develops_from UBERON:0001007 ! digestive system
relationship: develops_from UBERON:0001242 ! intestinal mucosa
relationship: develops_from UBERON:0001262 ! wall of intestine
relationship: develops_from UBERON:0001277 ! intestinal epithelium
relationship: develops_from UBERON:0001555 ! digestive tract
relationship: develops_from UBERON:0001983 ! crypt of Lieberkuhn
relationship: develops_from UBERON:0005409 ! alimentary part of gastrointestinal system
relationship: directly_develops_from CL:0002250 ! intestinal crypt stem cell
relationship: part_of UBERON:0013740 ! wall of crypt of Lieberkuhn
property_value: dcterms-date "2024-09-24T10:48:47Z" xsd:dateTime
[Term]
id: CL:4047023
name: intestinal lamina propria fibroblast
def: "A fibroblast located in the lamina propria of the intestinal mucosa. This cell expresses PDGFRα and CD81 and is negative for α-smooth muscle actin (α-SMA). This cell is predominantly located in the small intestine adjacent to myofibroblasts surrounding the crypts. It is capable of synthesizing extracellular matrix components and structural proteins such as collagen and elastin." [PMID:21252048, PMID:36032088]
synonym: "S1 fibroblast" RELATED [PMID:30270042]
is_a: CL:0000057 ! fibroblast
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000057 ! fibroblast
intersection_of: capable_of GO:0070278 ! extracellular matrix constituent secretion
intersection_of: part_of UBERON:0004780 ! gastrointestinal system lamina propria
relationship: capable_of GO:0070278 ! extracellular matrix constituent secretion
relationship: dc-contributor https://orcid.org/0009-0005-7919-4905
relationship: part_of UBERON:0004780 ! gastrointestinal system lamina propria
property_value: dcterms-date "2024-09-24T15:45:18Z" xsd:dateTime
[Term]
id: CL:4047025
name: type G cell of stomach
def: "Any type G enteroendocrine cell that is part of some epithelium of stomach." [FBC:Autogenerated]
is_a: CL:0000508 ! type G enteroendocrine cell
is_a: CL:1000222 ! stomach neuroendocrine cell
intersection_of: CL:0000508 ! type G enteroendocrine cell
intersection_of: part_of UBERON:0001276 ! epithelium of stomach
relationship: dc-contributor https://orcid.org/0009-0005-7919-4905
relationship: part_of UBERON:0001276 ! epithelium of stomach
property_value: dcterms-date "2024-10-24T10:43:22Z" xsd:dateTime
[Term]
id: CL:4047034
name: smooth muscle cell of stomach
def: "A smooth muscle cell that is part of the muscularis externa of the stomach wall. It is characterized by its fusiform shape, involuntary control, and ability to generate slow, sustained contractions. This cell is organized in distinct layers and is essential for gastric motility and digestion." [PMID:21443757, PMID:33630273]
is_a: CL:0000192 ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0008856 ! stomach muscularis externa
relationship: dc-contributor https://orcid.org/0009-0005-7919-4905
relationship: part_of UBERON:0008856 ! stomach muscularis externa
property_value: dcterms-date "2024-12-05T11:10:18Z" xsd:dateTime
[Term]
id: CL:4047036
name: stomach smooth muscle circular layer cell
def: "A smooth muscle cell located in the middle layer of the muscularis externa of the stomach wall. This cell is arranged concentrically with the stomach's longitudinal axis, forming a continuous sheet of contractile tissue. It is fusiform in shape, containing actin and myosin filaments that enable contraction without striations. This cell contributes to the mechanical digestion and movement of food within the stomach through coordinated contractions, and plays a role in forming the pyloric sphincter in the pyloric region." [PMID:11146428, PMID:32424507]
is_a: CL:4047034 ! smooth muscle cell of stomach
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0008857 ! stomach smooth muscle circular layer
relationship: dc-contributor https://orcid.org/0009-0005-7919-4905
relationship: part_of UBERON:0008857 ! stomach smooth muscle circular layer
property_value: dcterms-date "2024-12-09T10:40:58Z" xsd:dateTime
[Term]
id: CL:4047037
name: stomach smooth muscle inner oblique layer cell
def: "A smooth muscle cell found in the innermost layer of the muscularis externa of the stomach wall. This cell forms a unique layer of smooth muscle fibers oriented obliquely to the stomach's longitudinal axis. It is responsible for aiding in the mixing and churning of gastric contents, contributing to mechanical digestion within the stomach." [PMID:29493959]
synonym: "stomach smooth muscle oblique layer cell" EXACT []
is_a: CL:4047034 ! smooth muscle cell of stomach
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0008862 ! stomach smooth muscle inner oblique layer
relationship: dc-contributor https://orcid.org/0009-0005-7919-4905
relationship: part_of UBERON:0008862 ! stomach smooth muscle inner oblique layer
property_value: dcterms-date "2024-12-09T10:53:19Z" xsd:dateTime
[Term]
id: CL:4047101
name: liver-resident natural killer cell
def: "A natural killer cell resident to the liver, located in the hepatic sinusoids. In humans this cell type is distinguished from circulating natural killer cells by CD49a or CD69 gene expression. Liver-resident natural killer cells have also been shown to express CCR5, EOMES, KLRB1, GZMK, and CXCR6 in humans." [PMID:26330348, PMID:26639736, PMID:27798170, PMID:31114585, PMID:32351704, PMID:34230995, PMID:35865550]
comment: Liver-resident natural killer cells play a crucial role in modulating the immune response during inflammation by balancing cytotoxic activity and cytokine production, thereby contributing to the maintenance of liver homeostasis and protection against excessive tissue damage. {xref="PMID:34230995"}
synonym: "he-NK" EXACT [PMID:31114585]
synonym: "hepatic natural killer cells" EXACT [doi:10.3389/fimmu.2019.00946]
synonym: "hepatic NK" EXACT [doi:10.3389/fimmu.2019.00946]
synonym: "intrahepatic NK" EXACT [PMID:33828559]
synonym: "liver NK cell" EXACT [PMID:26639736]
synonym: "liver resident natural killer cell" EXACT [PMID:26330348]
synonym: "liver-specific natural killer cell" EXACT []
synonym: "lr-NK" EXACT [PMID:35726345]
is_a: CL:0000623 ! natural killer cell
intersection_of: CL:0000623 ! natural killer cell
intersection_of: located_in UBERON:0001281 ! hepatic sinusoid
relationship: dc-contributor https://orcid.org/0009-0005-7919-4905
relationship: located_in UBERON:0001281 ! hepatic sinusoid
property_value: dc-contributor "https://orcid.org/0000-0001-8134-3037" xsd:string
property_value: dcterms-date "2024-07-29T13:43:11Z" xsd:dateTime
[Term]
id: CL:4052001
name: multiciliated ependymal cell
def: "An ependymal cell that lines the lateral, third, and fourth ventricles of the brain. The cell is characterized by multiple motile cilia on its apical surface, which beats in a coordinated manner to facilitate the movement of cerebrospinal fluid (CSF), contributing to brain homeostasis." [PMID:25045600, PMID:28067220, PMID:37008045]
comment: multiciliated ependymal cell, with an average of 16 motile cilia per cell, exhibits two types of planar cell polarity (PCP): rotational polarity, with unidirectional cilia orientation, and translational polarity, with asymmetric cilia positioning in the apical area. This location-specific PCP varies across the ventricular wall, aligning with the direction of CSF flow. These cells are interconnected by adherens and gap junctions, which support intercellular communication and maintain the structural integrity of the ependymal layer. Unlike some other cell types, these cells lack tight junctions. {xref="PMID:25045600", xref="PMID:27311928"}
synonym: "E1" RELATED OMO:0003000 [PMID:28067220, PMID:37008045]
synonym: "multiciliated ependymal cells" BROAD [PMID:25045600]
is_a: CL:0000065 ! ependymal cell
is_a: CL:0005012 ! multiciliated epithelial cell
intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell
intersection_of: has_part GO:0031514 ! motile cilium
intersection_of: part_of UBERON:0004670 ! ependyma
intersection_of: RO:0000053 PATO:0010007 ! has characteristic multiciliated
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: has_part GO:0031514 ! motile cilium
relationship: part_of UBERON:0004670 ! ependyma
relationship: RO:0000053 PATO:0010007 ! has characteristic multiciliated
property_value: dcterms-date "2024-08-20T10:06:15Z" xsd:dateTime
[Term]
id: CL:4052002
name: syncytial cell
def: "A multinucleate cell formed by the fusion of multiple uninuclear cells through plasma membrane fusion. This process leads to a single large cell containing multiple nuclei within a shared cytoplasm." [PMID:20851884, Wikipedia:Syncytium]
synonym: "SC" RELATED OMO:0003000 [PMID:9067520]
synonym: "syncytium" EXACT [WBbt:0008074]
is_a: CL:0000228 ! multinucleate cell
intersection_of: CL:0000000 ! cell
intersection_of: output_of GO:0000768 ! syncytium formation by plasma membrane fusion
intersection_of: RO:0000053 PATO:0001908 ! has characteristic multinucleate
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: output_of GO:0000768 ! syncytium formation by plasma membrane fusion
relationship: RO:0000053 PATO:0001908 ! has characteristic multinucleate
property_value: dcterms-date "2024-08-15T10:38:46Z" xsd:dateTime
[Term]
id: CL:4052003
name: intestinal villus capillary endothelial cell
def: "A capillary endothelial cell that is part of the intestinal villus. This cell is highly fenestrated, with fenestrations most numerous at the villus tips, and plays a vital role in nutrient absorption and maintaining the selective permeability of the intestinal barrier." [PMID:18480313, PMID:35810168, PMID:38051275]
synonym: "villus blood capillary endothelial cells" BROAD [PMID:35810168]
synonym: "villus tip endothelial cell" RELATED [PMID:38051275]
is_a: CL:0000131 ! gut endothelial cell
is_a: CL:0000666 ! fenestrated endothelial cell
is_a: CL:0002144 ! capillary endothelial cell
intersection_of: CL:0002144 ! capillary endothelial cell
intersection_of: part_of UBERON:0001213 ! intestinal villus
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0001213 ! intestinal villus
property_value: dcterms-date "2024-09-17T10:03:25Z" xsd:dateTime
[Term]
id: CL:4052006
name: intestinal enteroendocrine progenitor
def: "An epithelial cell that is part of the crypt of Lieberkuhn, originating from intestinal stem cells and giving rise to enteroendocrine cells (EECs). In mouse and human, this cell can be characterized by the expression of Neurog3, and has the ability to proliferate and differentiate into multiple EEC subtypes. Its proliferative potential contributes to crypt growth, distinguishing it from fully differentiated EECs." [doi:/10.1038/s41467-021-27901-5, PMID:31756561, PMID:32531023, PMID:35913117, PMID:38260422]
comment: The EEC progenitor is also present in other organisms; for example, flies have EEC progenitors but lack intestinal crypts and do not express the same markers. Instead, they are Dl+ and Pros+. {xref="PMID:25670791"}
synonym: "EEC Progenitor" RELATED OMO:0003000 [PMID:31756561]
is_a: CL:0002563 ! intestinal epithelial cell
is_a: CL:0011026 ! progenitor cell
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: develops_from CL:0002250 ! intestinal crypt stem cell
relationship: part_of UBERON:0011184 ! epithelium of crypt of Lieberkuhn
property_value: dcterms-date "2024-09-20T12:13:26Z" xsd:dateTime
[Term]
id: CL:4052010
name: pre-theca cell
def: "A stromal cell that serves as a precursor to the theca cell layers in the ovary growing follicles. This cell is present in the early stages of follicular growth, particularly in smaller follicles. Unlike mature theca cell, a pre-theca cell is initially non-steroidogenic and lacks luteinizing hormone receptors." [PMID:20628033, PMID:31320652, PMID:36205477]
subset: cellxgene_subset
synonym: "early theca cell" EXACT [PMID:36205477]
synonym: "progenitor theca cell" EXACT [PMID:31320652]
is_a: CL:0002132 ! stromal cell of ovary
is_a: CL:0002174 ! follicular cell of ovary
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: develops_into CL:0000503 ! theca cell
relationship: part_of UBERON:0012186 ! ovary growing follicle
property_value: dcterms-date "2024-09-25T11:15:57Z" xsd:dateTime
[Term]
id: CL:4052012
name: interna theca cell
def: "A specialized theca cell that forms the inner, highly vascularized layer of the theca surrounding ovarian follicles. Originating from progenitor theca cells, the theca interna cell is steroidogenic, playing a crucial role in the production of androgens, which serves as a precursor for estrogen synthesis in granulosa cells. This cell expresses luteinizing hormone receptors, enabling it to respond to hormonal signals that regulate steroidogenesis." [PMID:15833266, PMID:31320652, PMID:32530882, Wikipedia:Theca_interna]
synonym: "androgenic theca cell" RELATED [PMID:36599970]
synonym: "inTC" RELATED OMO:0003000 [PMID:31320652]
synonym: "interna TC" RELATED OMO:0003000 [PMID:31320652]
synonym: "steroidogenic theca interna cell" RELATED [PMID:36599970]
is_a: CL:0000503 ! theca cell
is_a: CL:0000593 ! androgen secreting cell
intersection_of: CL:0000503 ! theca cell
intersection_of: part_of UBERON:0000157 ! theca interna
disjoint_from: CL:4052013 ! externa theca cell
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: develops_from CL:4052010 ! pre-theca cell
relationship: part_of UBERON:0000157 ! theca interna
property_value: dcterms-date "2024-09-30T11:10:15Z" xsd:dateTime
[Term]
id: CL:4052013
name: externa theca cell
def: "A specialized theca cell that forms the outer layer of the theca surrounding the ovarian follicle, appearing at the antral follicle. Originating from progenitor theca cells, theca externa cell is characterized by its fibroblast-like appearance and primarily function to provide structural support to the developing follicle. This cell produces collagen fibers and extracellular matrix components such as Col1a1 and Col1a2." [PMID:31320652, PMID:32530882, PMID:36758341, Wikipedia:Theca_externa]
synonym: "exTC" RELATED OMO:0003000 [PMID:31320652]
synonym: "externa TC" RELATED OMO:0003000 [PMID:31320652]
synonym: "structural theca cell" RELATED [PMID:36599970]
is_a: CL:0000503 ! theca cell
intersection_of: CL:0000503 ! theca cell
intersection_of: part_of UBERON:0000156 ! theca externa
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: develops_from CL:4052010 ! pre-theca cell
relationship: part_of UBERON:0000156 ! theca externa
property_value: dcterms-date "2024-09-30T11:10:15Z" xsd:dateTime
[Term]
id: CL:4052014
name: pancreatic islet capillary endothelial cell
def: "A capillary endothelial cell that is part of islet of Langerhans, characterized by a high density of fenestrations —approximately ten times greater than those in exocrine pancreatic capillaries. These fenestrations facilitate efficient hormone exchange, which is essential for maintaining glucose homeostasis. The cell's structure and function are regulated by the local production of vascular endothelial growth factor-A (VEGF-A), which maintains its fenestrated architecture." [PMID:16607697, PMID:27124642, PMID:28396983, PMID:33200981]
synonym: "islet endothelial cell" BROAD [PMID:16607697, PMID:28396983]
synonym: "pancreatic islet endothelial cell" BROAD [PMID:16607697]
is_a: CL:0000666 ! fenestrated endothelial cell
is_a: CL:0002144 ! capillary endothelial cell
intersection_of: CL:0002144 ! capillary endothelial cell
intersection_of: part_of UBERON:0000006 ! islet of Langerhans
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0000006 ! islet of Langerhans
property_value: dcterms-date "2024-09-30T14:36:12Z" xsd:dateTime
[Term]
id: CL:4052015
name: endocrine gland capillary endothelial cell
def: "Any capillary endothelial cell that is part of an endocrine gland." [PMID:18480313]
is_a: CL:0002144 ! capillary endothelial cell
intersection_of: CL:0002144 ! capillary endothelial cell
intersection_of: part_of UBERON:0002368 ! endocrine gland
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0002368 ! endocrine gland
property_value: dcterms-date "2024-09-30T15:27:49Z" xsd:dateTime
[Term]
id: CL:4052016
name: pituitary gland capillary endothelial cell
def: "A capillary endothelial cell that is part of the pituitary gland. This cell is characterized by its fenestrated structure which facilitates the efficient transport of hormones and other signaling molecules, essential for endocrine signalling." [PMID:10810312, PMID:32910242]
comment: In the anterior pituitary gland of rats, capillary endothelial cells are distinguished by numerous fenestrations, which are covered by a single-layered diaphragm. The diaphragm features a dense ring-like structure. {xref="PMID:4899902"}
is_a: CL:0000666 ! fenestrated endothelial cell
is_a: CL:2000004 ! pituitary gland cell
is_a: CL:2000044 ! brain microvascular endothelial cell
is_a: CL:4052015 ! endocrine gland capillary endothelial cell
intersection_of: CL:0002144 ! capillary endothelial cell
intersection_of: part_of UBERON:0000007 ! pituitary gland
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0000007 ! pituitary gland
property_value: dcterms-date "2024-09-30T15:31:45Z" xsd:dateTime
[Term]
id: CL:4052017
name: choroid plexus capillary endothelial cell
def: "A capillary endothelial cell that is part of the choroid plexus, characterized by its fenestrated nature with 60 to 80 nm fenestrations and lack of tight junctions. This fenestrated structure allows for the rapid delivery of water and other components, aiding in the production of cerebrospinal fluid (CSF)." [https://www.ncbi.nlm.nih.gov/books/NBK27998/, PMID:18480313, PMID:32375819]
is_a: CL:0000666 ! fenestrated endothelial cell
is_a: CL:0002144 ! capillary endothelial cell
is_a: CL:2000044 ! brain microvascular endothelial cell
intersection_of: CL:0002144 ! capillary endothelial cell
intersection_of: part_of UBERON:0001886 ! choroid plexus
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0001886 ! choroid plexus
property_value: dcterms-date "2024-10-01T11:38:22Z" xsd:dateTime
[Term]
id: CL:4052018
name: fallopian tube epithelial cell
def: "Any epithelial cell that is part of the fallopian tube." [Wikipedia:Fallopian_tube]
synonym: "oviduct epithelial cell" BROAD [Wikipedia:Fallopian_tube]
synonym: "uterine tube epithelial cell" EXACT [Wikipedia:Fallopian_tube]
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0003889 ! fallopian tube
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0003889 ! fallopian tube
property_value: dcterms-date "2024-10-01T12:09:12Z" xsd:dateTime
[Term]
id: CL:4052022
name: fallopian tube smooth muscle cell
def: "A smooth muscle cell that is part of the fallopian tube. This cell is responsible for peristaltic contractions that facilitate gamete and embryo transport, fluid mixing, and embryo admission to the uterus." [PMID:31183831, PMID:31613440]
comment: The fallopian tube smooth muscle cell in the human contracts dynamically in response to hormones and signaling molecules. Prostaglandins, particularly PGF2α and PGE2, have been shown to increase muscular contractions, while progesterone, levonorgestrel, mifepristone, oxytocin, and human chorionic gonadotropin (hCG) decrease them. These contractile responses are crucial for regulating gamete and embryo transport through the fallopian tube. {xref="PMID:18621753"}
synonym: "oviduct smooth muscle cell" BROAD [PMID:31613440]
synonym: "uterine tube smooth muscle cell" EXACT [PMID:31613440]
is_a: CL:0000192 ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0003889 ! fallopian tube
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0003889 ! fallopian tube
property_value: dcterms-date "2024-10-21T12:16:54Z" xsd:dateTime
[Term]
id: CL:4052023
name: luminal endometrial unciliated epithelial cell
def: "An epithelial cell that is part of the endometrial luminal epithelium, forming a continuous layer lining the uterine cavity. This cell undergoes cyclical changes during the menstrual cycle, proliferating under estrogen in the proliferative phase, and differentiating under progesterone in the secretory phase to prepare for potential implantation. During the window of implantation, this cell changes from a tall columnar shape to a shorter columnar or cuboidal form, loses polarity, and becomes receptive to blastocyst implantation." [PMID:32929266, PMID:36581776, PMID:38559249, PMID:39198675]
comment: The luminal endometrial unciliated epithelial cell expresses WNT7A, and LGR5 during the proliferative phase, transitioning to express VTCN1 and SULT1E1 in the early secretory phase, and LEFTY1, IL6, and PTGS1 in the mid- to late-secretory phases. {xref="PMID:39198675"}
is_a: CL:1001591 ! oviduct secretory cell
is_a: CL:4052050 ! luminal epithelial cell of endometrium
intersection_of: CL:0000066 ! epithelial cell
intersection_of: capable_of GO:0032940 ! secretion by cell
intersection_of: part_of UBERON:0011949 ! endometrium luminal epithelium
relationship: capable_of GO:0032940 ! secretion by cell
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0011949 ! endometrium luminal epithelium
property_value: dcterms-date "2024-10-22T12:02:23Z" xsd:dateTime
[Term]
id: CL:4052025
name: neuromuscular junction nucleus
def: "A specialized muscle nucleus that is part of an extrafusal muscle fiber, clustered at the postsynaptic side of the neuromuscular junction. This nucleus exhibits a distinct transcriptional profile, including acetylcholine receptor (AChR) subunit genes. It regulates the production of proteins essential for maintaining the structure and function of the neuromuscular junction, supporting efficient nerve-muscle signaling for muscle contraction." [PMID:33037211, PMID:33311457, PMID:33311464]
subset: cellxgene_subset
synonym: "neuromuscular junction myonuclei" EXACT OMO:0003004 [PMID:33311464]
synonym: "neuromuscular junction nuclei" EXACT OMO:0003004 [PMID:33311457]
synonym: "NMJ nuclues" RELATED OMO:0003000 []
is_a: GO:0005634 ! nucleus
intersection_of: GO:0005634 ! nucleus
intersection_of: overlaps GO:0098522 ! neuromuscular junction of skeletal muscle fiber
intersection_of: part_of CL:0008046 ! extrafusal muscle fiber
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: dc-contributor https://orcid.org/0009-0001-6947-615X
relationship: overlaps GO:0098522 ! neuromuscular junction of skeletal muscle fiber
relationship: part_of CL:0008046 ! extrafusal muscle fiber
property_value: dcterms-date "2024-10-31T11:09:04Z" xsd:dateTime
[Term]
id: CL:4052028
name: uterine natural killer cell
def: "A natural killer cell that is part of the uterus, specifically within the endometrium during the non-pregnant state and in the decidua during pregnancy. This cell exhibits dynamic changes in frequency throughout the menstrual cycle, with lower levels during menstruation and a significant increase during the mid-secretory phase and early pregnancy." [PMID:35720413, PMID:39198675, Wikipedia:Uterine_natural_killer_cells]
synonym: "endometrial natural killer cell" NARROW [PMID:35720413]
synonym: "uNK cell" RELATED OMO:0003000 [PMID:39198675]
is_a: CL:0000623 ! natural killer cell
intersection_of: CL:0000623 ! natural killer cell
intersection_of: part_of UBERON:0000995 ! uterus
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0000995 ! uterus
property_value: dcterms-date "2024-11-15T10:12:40Z" xsd:dateTime
[Term]
id: CL:4052030
name: adventitial fibroblast
def: "A fibroblast of the adventitia of a blood vessel. This cell contributes to vascular homeostasis, remodeling, and inflammation by producing extracellular matrix components, cytokines, and growth factors. Adventitial fibroblast can transition into an activated state during injury or disease, marked by increased proliferation, migration, matrix deposition, and contractile protein expression" [PMID:28705796, PMID:36718802]
comment: Single-cell transcriptomics of murine aorta identifies two adventitial fibroblast-specific markers, PDGFRA and DPEP1, which were validated at the protein level by immunohistochemistry and flow cytometry across human and murine arteries, highlighting fibroblast heterogeneity in health and cardiovascular disease (CVD) in humans and mice. {xref="PMID:36718802"}
subset: cellxgene_subset
is_a: CL:0000057 ! fibroblast
is_a: CL:0000151 ! secretory cell
is_a: CL:0002503 ! adventitial cell
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0005734 ! tunica adventitia of blood vessel
relationship: capable_of GO:0001816 ! cytokine production
relationship: capable_of GO:0070278 ! extracellular matrix constituent secretion
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0005734 ! tunica adventitia of blood vessel
property_value: dcterms-date "2024-12-05T11:01:15Z" xsd:dateTime
[Term]
id: CL:4052034
name: tuft cell of thymus
def: "A tuft cell that is part of the medullary epithelium of the thymus, characterized by lateral microvilli and specific markers, including L1CAM in both mice (Zhang et al., 2022) and humans (Sun et al., 2023), as well as MHC II in mice (Miller et al., 2018). This cell is pivotal in immune functions such as antigen presentation, central tolerance, and type 2 immunity. A tuft cell in the thymus exhibits characteristics of both a medullary thymic epithelial cell (mTEC) and a peripheral tuft cell. Its development is governed by transcription factors such as POU2F3." [PMID:30022164, PMID:30904566, PMID:35668088, PMID:36351364, PMID:36961668]
comment: A thymic tuft cell is a subset of terminally differentiated medullary thymic epithelial cell comprising 5-10% of total mTECs. Lineage-tracing studies indicate that this cell arises from mature MHCII mTECs, with development occurring through both Aire-dependent and Aire-independent pathways. However, its exact origins remain unclear. {xref="PMID:30904566"}
synonym: "thymic tuft cell" EXACT [PMID:30904566]
is_a: CL:0002204 ! tuft cell
is_a: CL:0002365 ! medullary thymic epithelial cell
intersection_of: CL:0002204 ! tuft cell
intersection_of: part_of UBERON:0003846 ! thymus epithelium
relationship: capable_of GO:0002491 ! antigen processing and presentation of endogenous peptide antigen via MHC class II
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0003846 ! thymus epithelium
property_value: dcterms-date "2025-01-16T11:29:54Z" xsd:dateTime
[Term]
id: CL:4052035
name: tuft cell of pancreatic duct
def: "A tuft cell that is part of the epithelium of pancreatic duct. Present in humans and rats, this cell is absent in the murine pancreas under normal conditions but emerges during acinar-to-ductal metaplasia triggered by injury, inflammation, or oncogenic mutations. It modulates the immune response and protects against pancreatic ductal adenocarcinoma progression by producing suppressive eicosanoids, such as prostaglandin D2. A tuft cell in the pancreatic duct highly expresses the transcription factor POU2F3, which is essential for its development and presence." [PMID:30904566, PMID:32717220]
synonym: "pancreatic brush cell" EXACT [PMID:9749964]
synonym: "pancreatic tuft cell" EXACT [PMID:32717220]
is_a: CL:0000068 ! duct epithelial cell
is_a: CL:0002204 ! tuft cell
is_a: CL:1001433 ! epithelial cell of exocrine pancreas
intersection_of: CL:0002204 ! tuft cell
intersection_of: part_of UBERON:0009970 ! epithelium of pancreatic duct
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0009970 ! epithelium of pancreatic duct
property_value: dcterms-date "2025-01-16T11:50:08Z" xsd:dateTime
[Term]
id: CL:4052036
name: tuft cell of nasal cavity
def: "A tuft cell that is part of the nasal cavity epithelium, located in both the respiratory and olfactory epithelia of the nose. This cell plays key roles in chemosensation, lipid mediator production, immune responses, and epithelial homeostasis." [PMID:30379593, PMID:38306414]
synonym: "nasal brush cell" EXACT [PMID:34692913]
synonym: "nasal tuft cell" EXACT [PMID:38306414]
is_a: CL:0002204 ! tuft cell
is_a: CL:0002631 ! epithelial cell of upper respiratory tract
intersection_of: CL:0002204 ! tuft cell
intersection_of: part_of UBERON:0005384 ! nasal cavity epithelium
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0005384 ! nasal cavity epithelium
property_value: dcterms-date "2025-01-21T09:04:03Z" xsd:dateTime
[Term]
id: CL:4052037
name: tuft cell of olfactory epithelium
def: "A tuft cell that is part of the olfactory epithelium, characterized by a globular body and the expression of neurogranin (Nrgn) in mice. This cell plays a crucial role in allergen recognition and regulating olfactory stem cell proliferation via TRPM5-dependent ATP sensing and cysteinyl leukotriene production. Unlike nasal respiratory tuft cells, it has low to absent expression of taste receptors, including the G protein Gα gustducin, and rarely contacts olfactory sensory neurons directly." [doi:/10.1101/2022.09.26.509561, PMID:38306414]
synonym: "olfactory tuft cell" EXACT [PMID:38306414]
synonym: "TPRM5+ tuft-MVC" RELATED [PMID:38306414]
synonym: "TRPM5+ microvillous cell" RELATED [PMID:38306414]
synonym: "TRPM5+ microvillous tuft cell" RELATED [doi:/10.1101/2022.09.26.509561]
synonym: "tuft-microvillous cell" RELATED [PMID:38306414]
is_a: CL:0002167 ! olfactory epithelial cell
is_a: CL:4052036 ! tuft cell of nasal cavity
intersection_of: CL:0002204 ! tuft cell
intersection_of: part_of UBERON:0001997 ! olfactory epithelium
relationship: capable_of GO:0072091 ! regulation of stem cell proliferation
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0001997 ! olfactory epithelium
property_value: dcterms-date "2025-02-06T15:03:53Z" xsd:dateTime
[Term]
id: CL:4052038
name: tuft cell of nasal cavity respiratory epithelium
def: "A tuft cell that is part of the nasal cavity respiratory epithelium. Acting as a chemosensor, it detects bitter taste ligands and bacterial signals via taste receptors, maintaining epithelial-microbial homeostasis by stimulating antimicrobial peptide secretion from adjacent epithelial cells. This cell is a major source of IL-25, promoting type 2 immune responses and potentially contributing to chronic rhinosinusitis (O'Leary et al., 2019)." [PMID:30379593, PMID:34932383, PMID:38306414]
synonym: "Gɑ-gustducin high respiratory tuft cell" RELATED [PMID:38306414]
synonym: "nasal respiratory solitary chemosensory cell" RELATED [PMID:38306414]
synonym: "tuft-solitary chemosensory cell" RELATED [PMID:38306414]
is_a: CL:4052036 ! tuft cell of nasal cavity
intersection_of: CL:0002204 ! tuft cell
intersection_of: part_of UBERON:0005385 ! nasal cavity respiratory epithelium
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0005385 ! nasal cavity respiratory epithelium
property_value: dcterms-date "2025-02-06T15:28:14Z" xsd:dateTime
[Term]
id: CL:4052039
name: tuft cell of submandibular gland
def: "A tuft cell that is part of the epithelium of the submandibular gland, localized to the striated ducts in mice, pigs, and humans, and to the main excretory ducts in rats. This cell is characterized by chemosensory functions, potential roles in immune regulation, and possible involvement in salivary secretion via acetylcholine release." [PMID:35993302, PMID:38098741, PMID:8874101]
is_a: CL:0002204 ! tuft cell
is_a: CL:0002251 ! epithelial cell of alimentary canal
intersection_of: CL:0002204 ! tuft cell
intersection_of: part_of UBERON:0003359 ! epithelium of submandibular gland
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0003359 ! epithelium of submandibular gland
property_value: dcterms-date "2025-02-12T10:38:11Z" xsd:dateTime
[Term]
id: CL:4052040
name: tuft cell of stomach
def: "A tuft cell that is part of the epithelium of the stomach. This cell is characterized by gastric chemosensation and immune regulation through IL-25 secretion, which activates ILC2s to produce IL-13, driving epithelial remodelling and tuft cell expansion. Unlike intestinal tuft cells, which are primarily involved in helminth defense and type 2 immunity, the tuft cell of the stomach is primarily involved in inflammation, metaplasia, and hyperplasia." [doi:/10.1101/2022.02.16.480779, PMID:22527717, PMID:38117182]
synonym: "gastric tuft cell" EXACT [PMID:38117182]
is_a: CL:0002178 ! epithelial cell of stomach
is_a: CL:0002204 ! tuft cell
intersection_of: CL:0002204 ! tuft cell
intersection_of: part_of UBERON:0001276 ! epithelium of stomach
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0001276 ! epithelium of stomach
property_value: dcterms-date "2025-02-12T11:24:56Z" xsd:dateTime
[Term]
id: CL:4052041
name: tuft cell of auditory tube
def: "A tuft cell that is part of the epithelium of the pharyngotympanic (auditory) tube. This chemosensory cell is often positioned near cholinoreceptive sensory nerve fibers, suggesting a role in neuroimmune communication. It detects chemical signals and releases neuropeptides, such as acetylcholine (ACh) and CGRP, which contribute to inflammatory responses that help protect deeper tissues from harmful substances." [PMID:30379593, PMID:32733896]
is_a: CL:0002204 ! tuft cell
is_a: CL:0002491 ! auditory epithelial cell
intersection_of: CL:0002204 ! tuft cell
intersection_of: part_of UBERON:0010062 ! pharyngotympanic tube epithelium
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0010062 ! pharyngotympanic tube epithelium
property_value: dcterms-date "2025-02-12T12:00:10Z" xsd:dateTime
[Term]
id: CL:4052042
name: tuft cell of urethra
def: "A tuft cell that is part of the epithelium of the urethra. This cell monitors urethral contents by detecting chemical stimuli, such as bitter compounds and sugars. Upon activation, it stimulates sensory nerve fibres and triggers detrusor muscle contraction, likely aiding in pathogen clearance by promoting bladder emptying." [PMID:30379593, PMID:36993541, PMID:38548667]
comment: Urethral tuft cells are heterogeneous, with both cholinergic and non-cholinergic populations present. {xref="PMID:27680547"}
synonym: "urethral brush cell" EXACT [PMID:38548667]
synonym: "urethral cholinergic chemosensory cell" EXACT [PMID:38548667]
synonym: "urethral tuft cell" EXACT [PMID:38548667]
is_a: CL:0002204 ! tuft cell
is_a: CL:1000296 ! epithelial cell of urethra
intersection_of: CL:0002204 ! tuft cell
intersection_of: part_of UBERON:0002325 ! epithelium of urethra
relationship: capable_of GO:1904320 ! positive regulation of smooth muscle contraction involved in micturition
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0002325 ! epithelium of urethra
property_value: dcterms-date "2025-02-12T14:39:03Z" xsd:dateTime
[Term]
id: CL:4052045
name: steroidogenic stromal cell of ovary
def: "A stromal cell that is part of the ovarian stroma, characterized by its ability to synthesize steroid hormones." [doi:/10.1101/2024.12.15.628550, PMID:36205477]
synonym: "Enpp2− interstitial cell" RELATED [PMID:36205477]
synonym: "steroidogenic interstitial stromal cell" BROAD [PMID:36205477]
synonym: "steroidogenic stromal cell" BROAD [PMID:36205477]
is_a: CL:0002132 ! stromal cell of ovary
intersection_of: CL:0000499 ! stromal cell
intersection_of: capable_of GO:0120178 ! steroid hormone biosynthetic process
intersection_of: part_of UBERON:0006960 ! ovary stroma
relationship: capable_of GO:0120178 ! steroid hormone biosynthetic process
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0006960 ! ovary stroma
property_value: dcterms-date "2025-03-05T13:37:44Z" xsd:dateTime
[Term]
id: CL:4052049
name: striated cell of salivary gland
def: "An columnar/cuboidal epithelial cell that is part of the striated duct of salivary gland, characterized by basal striations formed by infoldings of the plasma membrane. This cell play a crucial role in modifying the electrolyte composition and concentration of saliva through active ion transport, particularly the absorption of sodium and secretion of potassium." [PMID:30855909, PMID:34147989, PMID:36726292]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "SD cells" BROAD [PMID:11590591]
synonym: "striated duct cells" BROAD [PMID:11590591]
is_a: CL:0000068 ! duct epithelial cell
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
is_a: CL:1001596 ! salivary gland glandular cell
intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell
intersection_of: part_of UBERON:0014729 ! striated duct of salivary gland
relationship: capable_of GO:0036376 ! sodium ion export across plasma membrane
relationship: capable_of GO:1990573 ! potassium ion import across plasma membrane
relationship: dc-contributor https://orcid.org/0000-0003-4389-9821
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0014729 ! striated duct of salivary gland
relationship: part_of UBERON:0015766 ! epithelium of duct of salivary gland
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2024-09-11T10:00:25Z" xsd:dateTime
[Term]
id: CL:4052050
name: luminal epithelial cell of endometrium
def: "An epithelial cell that is part of an endometrium luminal epithelium." [PMID:36273006]
synonym: "endometrial luminal epithelial cell" EXACT [PMID:31317179]
is_a: CL:0002149 ! epithelial cell of uterus
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0011949 ! endometrium luminal epithelium
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0011949 ! endometrium luminal epithelium
property_value: dcterms-date "2025-03-13T13:46:13Z" xsd:dateTime
[Term]
id: CL:4052058
name: Merkel cell of epidermis
def: "A Merkel cell found mainly in the basal layer of the epidermis and the outer root sheath of hair follicles, particularly concentrated in areas with high tactile acuity, such as touch domes, hair follicles, and fingertips." [PMID:19834574, PMID:2274847, PMID:30415995, Wikipedia:Merkel_cell]
synonym: "epdiermal Merkel cell" EXACT [PMID:6207057]
is_a: CL:0000242 ! Merkel cell
is_a: CL:0000362 ! epidermal cell
intersection_of: CL:0000242 ! Merkel cell
intersection_of: part_of UBERON:0001003 ! skin epidermis
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0001003 ! skin epidermis
property_value: dcterms-date "2025-06-11T10:01:40Z" xsd:dateTime
[Term]
id: CL:4052060
name: spinous cell
def: "A differentiating keratinocyte found in the epidermis and oral epithelium, located in the stratum spinosum, characterized by a spiny appearance due to abundant intercellular desmosomal junctions." [PMID:34283481, wikipedia:Spinous_cell]
synonym: "prickle cell" EXACT [wikipedia:Spinous_cell]
is_a: CL:0000312 ! keratinocyte
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: has_part GO:0030057 ! desmosome
relationship: RO:0000053 PATO:0001365 ! has characteristic spiny
property_value: dcterms-date "2025-07-02T12:21:06Z" xsd:dateTime
[Term]
id: CL:4052061
name: epidermal keratinocyte
def: "A keratinocyte of the skin epidermis that synthesizes keratin and undergoes successive stages of differentiation as it migrates from the basal layer to the cornified (stratum corneum) layer. These differentiation stages include the basal, spinous (prickle), and granular cell layers. This cell is central to epidermal homeostasis, mediating wound healing, immune modulation, including the secretion of cytokines and chemokines that recruit neutrophils (Simmons and Gallo, 2024), and intercellular communication with adjacent melanocytes (Marrapodi and Bellei, 2024)." [MESH:D015603, PMID:15749908, PMID:19727116, PMID:38473275, PMID:39115524, wikipedia:Keratinocyte]
comment: Keratinocytes are reportedly CDw210a(IL-10RA)-negative , CDw210b(IL-10RB)-positive, IL22Ra1-positive, Human keratinocytes are reportedly capable of secreting BD-2, BD-3, hCAP-18, CXCL1, CXCL5, CXCL8, elafin, MMP-3, NGAL, PDGF-A, S100A7, S100A8, and S100A9. Transcription factors: STAT3-positive. {xref="PMID:15749908", xref="PMID:19727116"}
synonym: "keratincyte of epidermis" EXACT []
synonym: "skin keratinocyte" EXACT [PMID:39185948]
is_a: CL:0000312 ! keratinocyte
is_a: CL:0000362 ! epidermal cell
intersection_of: CL:0000312 ! keratinocyte
intersection_of: part_of UBERON:0001003 ! skin epidermis
relationship: capable_of GO:0090023 ! positive regulation of neutrophil chemotaxis
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0001003 ! skin epidermis
property_value: dcterms-date "2025-07-02T12:32:13Z" xsd:dateTime
[Term]
id: CL:4052064
name: nail matrix keratinocyte
def: "A keratinocyte that is part of the nail matrix epithelium, distinguished by its high proliferative capacity and its role in nail plate formation via onychokeratinization, a differentiation process that uniquely bypasses the formation of a granular layer, resulting in the production of hard, compact keratin. Unlike skin epidermal keratinocytes, this cell expresses a distinctive mix of hard (hair-type) and select epidermal keratins (Kitahara and Ogawa, 1993). In humans, LGR6 and WNT6 are enriched in the basal compartment, with LGR6 marking nail stem cells in both mice and humans, and exhibiting strong expression in the human proximal nail matrix (Kim et al., 2021)." [PMID:28098391, PMID:30969555, PMID:34099859, PMID:39044464, PMID:7679137]
synonym: "nail matrix epithelial keratinocyte" EXACT [PMID:39044464]
is_a: CL:4052061 ! epidermal keratinocyte
intersection_of: CL:0000312 ! keratinocyte
intersection_of: part_of UBERON:0002283 ! nail matrix
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0002283 ! nail matrix
property_value: dcterms-date "2025-07-22T15:30:00Z" xsd:dateTime
[Term]
id: CL:4052065
name: serous acinar cell of salivary gland
def: "An acinar cell of the salivary gland, characterized by a pyramidal or triangular shape with a spherical nucleus and abundant eosinophilic zymogen granules. This cell secretes watery, enzyme‐rich fluid containing α-amylase, proline-rich proteins, and secretory immunoglobulins for starch digestion and antimicrobial defence. In humans and mice, serous acinar cell predominates in the parotid gland and to a lesser extent in the submandibular gland, where it exists alongside mucous acinar cells (Maruyama et al., 2019)." [PMID:29383862, PMID:32829674, PMID:35343828]
is_a: CL:0000313 ! serous secreting cell
is_a: CL:0002623 ! acinar cell of salivary gland
intersection_of: CL:0000313 ! serous secreting cell
intersection_of: CL:0002623 ! acinar cell of salivary gland
intersection_of: part_of UBERON:0013232 ! serous acinus
relationship: capable_of GO:0005983 ! starch catabolic process
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: has_part GO:0042588 ! zymogen granule
relationship: part_of UBERON:0013232 ! serous acinus
property_value: dcterms-date "2025-08-05T15:24:46Z" xsd:dateTime
[Term]
id: CL:4052066
name: mucous acinar cell of salivary gland
def: "An acinar cell of the salivary gland, responsible for producing a viscous, mucin‐rich solution, thereby facilitating lubrication and protection of the oral mucosa. This cell is characterized by an elongated shape, clear cytoplasm filled with mucin granules, and a basally compressed nucleus (Barrows et al., 2020). In humans and mice, the mucous acinar cell predominates in the sublingual gland and minor salivary glands, while also being present in mixed glands such as the submandibular gland, where it coexists with serous acinar cells (Maruyama et al., 2019)." [PMID:29383862, PMID:32829674, PMID:35343828]
is_a: CL:0000319 ! mucus secreting cell
is_a: CL:0002623 ! acinar cell of salivary gland
intersection_of: CL:0002623 ! acinar cell of salivary gland
intersection_of: part_of UBERON:0014717 ! mucous acinus
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: has_part GO:0098594 ! mucin granule
relationship: part_of UBERON:0014717 ! mucous acinus
property_value: dcterms-date "2025-08-05T15:33:46Z" xsd:dateTime
[Term]
id: CL:4052108
name: IgD-negative class switched memory B cell
def: "A class switched memory B cell that lacks IgD on the cell surface." [PMID:20839340, PMID:32741082, PMID:36617261, PMID:37254600]
is_a: CL:0000972 ! class switched memory B cell
is_a: CL:0001053 ! IgD-negative memory B cell
intersection_of: CL:0000972 ! class switched memory B cell
intersection_of: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex
relationship: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
property_value: dcterms-date "2025-12-08T10:33:49Z" xsd:dateTime
[Term]
id: CL:4072102
name: Purkinje layer interneuron
def: "A type of GABAergic interneuron residing in the Purkinje cell layer of the cerebellar cortex." [PMID:35803588]
synonym: "PLI" RELATED OMO:0003000 [PMID:35803588]
is_a: CL:4023057 ! cerebellar inhibitory GABAergic interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0002100 UBERON:0002979 ! has soma location Purkinje cell layer of cerebellar cortex
relationship: RO:0002100 UBERON:0002979 ! has soma location Purkinje cell layer of cerebellar cortex
property_value: dcterms-date "2025-04-29T13:06:36Z" xsd:dateTime
[Term]
id: CL:4072103
name: hair follicle dermal stem cell
def: "A bipotent mesenchymal stem cell that resides in the dermal sheath, specifically within the dermal sheath cup at the base of the hair follicle, characterized by its capacity for self-renewal and differentiation into both dermal sheath and dermal papilla cells throughout hair cycling. In humans, this cell is marked by enriched expression of gremlin-2 (GREM2) and dipeptidase-1 (DPEP1), and acts as a progenitor reservoir sustaining and regenerating the follicle's mesenchymal compartments." [PMID:25465495, PMID:29691589, PMID:35036581, PMID:35069694]
synonym: "dermal sheath cup cell" NARROW [PMID:38016881]
synonym: "hfDSC" RELATED OMO:0003000 [PMID:25465495]
is_a: CL:0000134 ! mesenchymal stem cell
is_a: CL:0002559 ! hair follicle cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: part_of UBERON:0002073 ! hair follicle
relationship: capable_of GO:0042634 ! regulation of hair cycle
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: part_of UBERON:0002073 ! hair follicle
creation_date: 2025-11-05T11:49:53Z
[Term]
id: CL:4072104
name: fibrochondrocyte
def: "A chondrocyte with hybrid fibroblastic-chondrogenic characteristics found in fibrocartilage, particularly in the avascular inner zone and transitional middle zone of the meniscus. In humans, fibrochondrocytes are marked by predominant expression of type I collagen (COL1A1) and fibril-associated collagens (COL3A1, COL6A1), while retaining type II collagen (COL2A1) expression and exhibiting lower SOX9 than hyaline chondrocytes. This molecular profile underlies the synthesis of abundant type I collagen essential for fibrocartilage matrix and reflects an intermediate phenotype between fibroblast and chondrocyte." [PMID:28939894, PMID:31871141, PMID:34608249]
synonym: "FC" RELATED OMO:0003000 [PMID:31871141]
synonym: "fibrocartilage chondrocyte" EXACT [PMID:34608249]
synonym: "meniscus fibrochondrocyte" NARROW [PMID:28939894]
is_a: CL:0000138 ! chondrocyte
intersection_of: CL:0000138 ! chondrocyte
intersection_of: part_of UBERON:0001995 ! fibrocartilage
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
relationship: develops_from CL:0020021 ! fibrochondrocyte progenitor cell
relationship: part_of UBERON:0001995 ! fibrocartilage
relationship: RO:0002292 PR:000003264 ! expresses collagen alpha-1(I) chain
relationship: RO:0002292 PR:000003328 ! expresses collagen alpha-1(III) chain
relationship: RO:0002292 PR:000003353 ! expresses collagen alpha-1(VI) chain
[Term]
id: CL:7770004
name: suprabasal cell
def: "An epithelial cell that resides in the layer(s) immediately above the basal layer in stratified or pseudostratified epithelia. This cell mainly originates from basal cells and is found across various tissues, including skin, esophagus, oral mucosa, airway, and cornea." [PMID:17020902, PMID:30837987, PMID:32187560, PMID:32726565, PMID:37672481]
is_a: CL:0000066 ! epithelial cell
relationship: dc-contributor https://orcid.org/0009-0000-8480-9277
property_value: dcterms-date "2025-09-05T07:59:28Z" xsd:dateTime
[Term]
id: COB:0000011
name: atom
def: "A material entity consisting of exactly one atomic nucleus and the electron(s) orbiting it." []
is_a: BFO:0000040 ! material entity
disjoint_from: COB:0000013 ! molecule
relationship: has_part CHEBI:33252 ! atomic nucleus
property_value: editor_note "This atom is closely related to ChEBI's atom, but not exactly equivalent to." xsd:string
[Term]
id: COB:0000013
name: molecule
def: "A material entity that consists of two or more atoms that are all connected via covalent bonds such that any atom can be transitively connected with any other atom." []
is_a: BFO:0000040 ! material entity
relationship: has_part COB:0000011 ! atom
property_value: editor_note "This molecular entity is different than ChEBI's 'molecular entity'." xsd:string
property_value: editor_note "We would like to have cardinality restrictions on the logic, but there are some technical limitations." xsd:string
[Term]
id: COB:0000021
name: gross anatomical part
def: "A part of a multicellular organism that is a collection of cell components that are not all contained in one cell." []
is_a: UBERON:0000465 ! material anatomical entity
[Term]
id: COB:0000022
name: organism
def: "A material entity that is a maximal functionally integrated unit that develops from a program encoded in a genome" []
is_a: UBERON:0000465 ! material anatomical entity
property_value: editor_note "'Maximal functionally integrated unit' is intended to express unity, which Barry considers synonymous with BFO 'object'." xsd:string
property_value: editor_note "Includes virus - we will later have a class for cellular organisms." xsd:string
[Term]
id: COB:0000080
name: complex of molecules
def: "A complex of two or more molecules that are not covalently bound." []
is_a: BFO:0000040 ! material entity
relationship: has_part COB:0000013 ! molecule
[Term]
id: COB:0000502
name: characteristic
[Term]
id: GO:0000011
name: vacuole inheritance
def: "The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:14616069]
is_a: GO:0007033 ! vacuole organization
is_a: GO:0048308 ! organelle inheritance
intersection_of: GO:0048308 ! organelle inheritance
intersection_of: results_in_distribution_of GO:0005773 ! vacuole
relationship: never_in_taxon NCBITaxon:4896
relationship: results_in_distribution_of GO:0005773 ! vacuole
[Term]
id: GO:0000018
name: regulation of DNA recombination
def: "Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents." [GOC:go_curators, ISBN:0198506732]
is_a: GO:0051052 ! regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006310 ! regulates (processual) DNA recombination
relationship: RO:0002211 GO:0006310 ! regulates (processual) DNA recombination
[Term]
id: GO:0000035
name: acyl binding
def: "Binding to an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid." [GOC:curators, ISBN:0198506732]
synonym: "acyl-CoA or acyl binding" BROAD []
is_a: GO:0036094 ! small molecule binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:22221 ! has primary input acyl group
relationship: RO:0004009 CHEBI:22221 ! has primary input acyl group
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21211" xsd:anyURI
[Term]
id: GO:0000041
name: transition metal ion transport
def: "The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]
synonym: "transition metal transport" EXACT []
is_a: GO:0030001 ! metal ion transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:33515 ! has primary input transition element cation
relationship: RO:0004009 CHEBI:33515 ! has primary input transition element cation
[Term]
id: GO:0000048
name: peptidyltransferase activity
def: "Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2). This reaction is catalyzed by a ribozyme." [PMID:11433365, PMID:9242921]
xref: EC:2.3.2.12
xref: MetaCyc:PEPTIDYLTRANSFERASE-RXN
xref: Reactome:R-HSA-156912 "Peptide transfer from P-site tRNA to the A-site tRNA"
is_a: GO:0016755 ! aminoacyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein
is_a: GO:0140101 ! catalytic activity, acting on a tRNA
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/22192" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/25493" xsd:anyURI
[Term]
id: GO:0000049
name: tRNA binding
alt_id: GO:0000946
def: "Binding to a transfer RNA." [GOC:ai]
synonym: "base pairing with tRNA" NARROW []
xref: Reactome:R-HSA-2408509 "Sec-tRNA(Sec) binds to EEFSEC:GTP"
is_a: GO:0003723 ! RNA binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:17843 ! has primary input transfer RNA
relationship: RO:0004009 CHEBI:17843 ! has primary input transfer RNA
[Term]
id: GO:0000070
name: mitotic sister chromatid segregation
alt_id: GO:0016359
def: "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl]
subset: goslim_pombe
synonym: "mitotic chromosome segregation" EXACT []
synonym: "mitotic sister-chromatid adhesion release" NARROW []
xref: Reactome:R-HSA-2500257 "Resolution of Sister Chromatid Cohesion"
is_a: GO:0000819 ! sister chromatid segregation
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0098813 ! nuclear chromosome segregation
intersection_of: part_of GO:0140014 ! mitotic nuclear division
relationship: in_taxon NCBITaxon:2759 ! Eukaryota
relationship: part_of GO:0140014 ! mitotic nuclear division
[Term]
id: GO:0000139
name: Golgi membrane
def: "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
synonym: "Golgi apparatus membrane" EXACT []
is_a: GO:0098588 ! bounding membrane of organelle
intersection_of: GO:0016020 ! membrane
intersection_of: bounding_layer_of GO:0005794 ! Golgi apparatus
relationship: bounding_layer_of GO:0005794 ! Golgi apparatus
relationship: in_taxon NCBITaxon:2759 ! Eukaryota
relationship: part_of GO:0005794 ! Golgi apparatus
[Term]
id: GO:0000166
name: nucleotide binding
def: "Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
is_a: GO:1901265 ! nucleoside phosphate binding
is_a: GO:1901363 ! heterocyclic compound binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:36976 ! has primary input nucleotide
relationship: RO:0004009 CHEBI:36976 ! has primary input nucleotide
[Term]
id: GO:0000226
name: microtubule cytoskeleton organization
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
subset: goslim_pombe
synonym: "microtubule cytoskeleton organisation" EXACT [GOC:mah]
synonym: "microtubule cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007010 ! cytoskeleton organization
is_a: GO:0007017 ! microtubule-based process
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0015630 ! results in organization of microtubule cytoskeleton
relationship: RO:0002592 GO:0015630 ! results in organization of microtubule cytoskeleton
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/23114" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/23195" xsd:anyURI
[Term]
id: GO:0000228
name: nuclear chromosome
def: "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah]
subset: goslim_chembl
subset: goslim_generic
synonym: "nuclear interphase chromosome" NARROW []
is_a: GO:0005694 ! chromosome
intersection_of: GO:0005694 ! chromosome
intersection_of: part_of GO:0005634 ! nucleus
relationship: in_taxon NCBITaxon:2759 ! Eukaryota
relationship: part_of GO:0005634 ! nucleus
relationship: part_of GO:0031981 ! nuclear lumen
[Term]
id: GO:0000271
name: polysaccharide biosynthetic process
def: "The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:go_curators]
synonym: "glycan biosynthesis" EXACT []
synonym: "glycan biosynthetic process" EXACT []
synonym: "polysaccharide anabolism" EXACT []
synonym: "polysaccharide biosynthesis" EXACT []
synonym: "polysaccharide formation" EXACT []
synonym: "polysaccharide synthesis" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0016051 ! carbohydrate biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:18154 ! has primary output polysaccharide
relationship: RO:0004008 CHEBI:18154 ! has primary output polysaccharide
[Term]
id: GO:0000272
name: polysaccharide catabolic process
alt_id: GO:0044244
def: "The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [PMID:33139480]
synonym: "multicellular organismal polysaccharide catabolic process" NARROW []
synonym: "polysaccharide breakdown" EXACT []
synonym: "polysaccharide catabolism" EXACT []
synonym: "polysaccharide degradation" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:0016052 ! carbohydrate catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:18154 ! has primary input polysaccharide
relationship: RO:0004009 CHEBI:18154 ! has primary input polysaccharide
[Term]
id: GO:0000278
name: mitotic cell cycle
alt_id: GO:0007067
def: "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194]
comment: Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle.
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_yeast
synonym: "mitosis" RELATED []
xref: Reactome:R-HSA-69278 "Cell Cycle, Mitotic"
xref: Wikipedia:Mitosis
is_a: GO:0007049 ! cell cycle
intersection_of: GO:0007049 ! cell cycle
intersection_of: has_part GO:0140014 ! mitotic nuclear division
relationship: has_part GO:0140014 ! mitotic nuclear division
relationship: in_taxon NCBITaxon:2759 ! Eukaryota
[Term]
id: GO:0000280
name: nuclear division
def: "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." [GOC:mah]
subset: goslim_pir
synonym: "karyokinesis" RELATED []
is_a: GO:0048285 ! organelle fission
intersection_of: GO:0048285 ! organelle fission
intersection_of: results_in_fission_of GO:0005634 ! nucleus
relationship: results_in_fission_of GO:0005634 ! nucleus
[Term]
id: GO:0000295
name: adenine nucleotide transmembrane transporter activity
def: "Enables the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of a membrane to the other." [PMID:11566870]
xref: Reactome:R-HSA-389652 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP"
is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity
intersection_of: GO:0015215 ! nucleotide transmembrane transporter activity
intersection_of: RO:0004009 CHEBI:61293 ! has primary input adenyl nucleotide
relationship: part_of GO:0051503 ! adenine nucleotide transport
relationship: RO:0004009 CHEBI:61293 ! has primary input adenyl nucleotide
[Term]
id: GO:0000313
name: organellar ribosome
def: "A ribosome contained within a subcellular membrane-bounded organelle." [GOC:mah, GOC:mcc]
is_a: GO:0005840 ! ribosome
intersection_of: GO:0005840 ! ribosome
intersection_of: part_of GO:0043226 ! organelle
relationship: in_taxon NCBITaxon:131567 ! cellular organism
relationship: part_of GO:0043226 ! organelle
[Term]
id: GO:0000323
name: lytic vacuole
def: "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc]
is_a: GO:0005773 ! vacuole
relationship: in_taxon NCBITaxon:131567 ! cellular organism
[Term]
id: GO:0000578
name: embryonic axis specification
def: "The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo." [GOC:dph, GOC:go_curators, GOC:sdb_2009, GOC:tb]
synonym: "embryonic axis determination" RELATED []
is_a: GO:0009798 ! axis specification
is_a: GO:0009880 ! embryonic pattern specification
relationship: in_taxon NCBITaxon:131567 ! cellular organism
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
[Term]
id: GO:0000740
name: nuclear membrane fusion
def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus." [GOC:elh]
is_a: GO:0071763 ! nuclear membrane organization
is_a: GO:0090174 ! organelle membrane fusion
intersection_of: GO:0061025 ! membrane fusion
intersection_of: RO:0012008 GO:0031965 ! results in fusion of nuclear membrane
relationship: RO:0012008 GO:0031965 ! results in fusion of nuclear membrane
[Term]
id: GO:0000741
name: karyogamy
alt_id: GO:0007335
def: "The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei." [GOC:elh]
synonym: "nuclear fusion" EXACT []
synonym: "nuclear fusion during karyogamy" EXACT []
xref: Wikipedia:Karyogamy
is_a: GO:0006997 ! nucleus organization
is_a: GO:0048284 ! organelle fusion
intersection_of: GO:0048284 ! organelle fusion
intersection_of: RO:0012008 GO:0005634 ! results in fusion of nucleus
relationship: part_of GO:0006997 ! nucleus organization
relationship: RO:0012008 GO:0005634 ! results in fusion of nucleus
[Term]
id: GO:0000768
name: syncytium formation by plasma membrane fusion
def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mtg_muscle, GOC:tb]
synonym: "cell fusion" BROAD []
is_a: GO:0006949 ! syncytium formation
is_a: GO:0140253 ! cell-cell fusion
intersection_of: GO:0006949 ! syncytium formation
intersection_of: has_part GO:0045026 ! plasma membrane fusion
relationship: has_part GO:0045026 ! plasma membrane fusion
relationship: in_taxon NCBITaxon:2759 ! Eukaryota
[Term]
id: GO:0000785
name: chromatin
alt_id: GO:0000789
alt_id: GO:0000790
alt_id: GO:0005717
def: "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]
comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore.
synonym: "chromosome scaffold" RELATED []
synonym: "cytoplasmic chromatin" NARROW []
synonym: "nuclear chromatin" NARROW []
xref: NIF_Subcellular:sao1615953555
is_a: GO:0110165 ! cellular anatomical entity
relationship: in_taxon NCBITaxon:131567 ! cellular organism
relationship: part_of GO:0005694 ! chromosome
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28301" xsd:anyURI
[Term]
id: GO:0000791
name: euchromatin
alt_id: GO:0005719
alt_id: GO:0035327
def: "A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation." [PMID:32017156]
synonym: "nuclear euchromatin" RELATED []
synonym: "transcriptionally active chromatin" EXACT []
xref: NIF_Subcellular:sao445485807
xref: Wikipedia:Euchromatin
is_a: GO:0000785 ! chromatin
relationship: in_taxon NCBITaxon:131567 ! cellular organism
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/22355" xsd:anyURI
[Term]
id: GO:0000792
name: heterochromatin
alt_id: GO:0005720
alt_id: GO:0035328
def: "A compact and highly condensed form of chromatin that is refractory to transcription." [PMID:32017156]
synonym: "nuclear heterochromatin" NARROW []
synonym: "transcriptionally inactive chromatin" EXACT []
synonym: "transcriptionally silent chromatin" EXACT []
xref: NIF_Subcellular:sao581845896
xref: Wikipedia:Heterochromatin
is_a: GO:0000785 ! chromatin
relationship: in_taxon NCBITaxon:131567 ! cellular organism
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/22355" xsd:anyURI
[Term]
id: GO:0000819
name: sister chromatid segregation
def: "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets." [GOC:ai, GOC:elh]
is_a: GO:0051276 ! chromosome organization
is_a: GO:0098813 ! nuclear chromosome segregation
[Term]
id: GO:0000902
name: cell morphogenesis
alt_id: GO:0007148
alt_id: GO:0045790
alt_id: GO:0045791
def: "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_yeast
synonym: "cellular morphogenesis" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 CL:0000000 ! results in morphogenesis of cell
relationship: in_taxon NCBITaxon:131567 ! cellular organism
relationship: RO:0002298 CL:0000000 ! results in morphogenesis of cell
[Term]
id: GO:0001101
name: response to acid chemical
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:go_curators, GOC:rn]
comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if an organism were responding to glutamate, then the response would be glutamate-specific; the organism is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0010447 'response to acidic pH' instead.
subset: gocheck_do_not_annotate
synonym: "response to acid" BROAD []
synonym: "response to acid anion" RELATED []
synonym: "response to oxoanion" RELATED []
is_a: GO:0042221 ! response to chemical
[Term]
id: GO:0001501
name: skeletal system development
def: "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton)." [GOC:dph, GOC:jid, GOC:tb]
synonym: "skeletal development" EXACT []
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001434 ! results in development of skeletal system
relationship: in_taxon NCBITaxon:33213 ! Bilateria
relationship: RO:0002296 UBERON:0001434 ! results in development of skeletal system
[Term]
id: GO:0001503
name: ossification
def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo, PMID:17572649]
comment: Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'.
synonym: "bone biosynthesis" EXACT []
synonym: "bone formation" EXACT []
synonym: "osteogenesis" EXACT []
xref: Wikipedia:Ossification
is_a: GO:0032501 ! multicellular organismal process
intersection_of: GO:0032501 ! multicellular organismal process
intersection_of: RO:0002297 UBERON:0001474 ! results in formation of anatomical entity bone element
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002297 UBERON:0001474 ! results in formation of anatomical entity bone element
[Term]
id: GO:0001504
name: neurotransmitter uptake
def: "The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387]
subset: goslim_synapse
synonym: "neurotransmitter import" EXACT [GOC:dph, GOC:tb]
synonym: "neurotransmitter import into glial cell" NARROW []
synonym: "neurotransmitter import into neuron" NARROW []
synonym: "neurotransmitter recycling" BROAD []
xref: Reactome:R-HSA-112313 "Neurotransmitter uptake and metabolism In glial cells"
is_a: GO:0006836 ! neurotransmitter transport
is_a: GO:0098657 ! import into cell
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: RO:0002339 GO:0005829 ! has target end location cytosol
[Term]
id: GO:0001507
name: acetylcholine catabolic process in synaptic cleft
def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine that occurs in the synaptic cleft during synaptic transmission." [GOC:ai]
synonym: "acetylcholine breakdown in synaptic cleft" EXACT []
synonym: "acetylcholine degradation in synaptic cleft" EXACT []
is_a: GO:0006581 ! acetylcholine catabolic process
intersection_of: GO:0006581 ! acetylcholine catabolic process
intersection_of: BFO:0000066 GO:0043083 ! occurs in synaptic cleft
relationship: BFO:0000066 GO:0043083 ! occurs in synaptic cleft
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: part_of GO:0007271 ! synaptic transmission, cholinergic
[Term]
id: GO:0001508
name: action potential
def: "A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities." [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8]
comment: Action potentials typically propagate across excitable membranes. This class covers both action potentials that propagate and those that fail to do so.
is_a: GO:0042391 ! regulation of membrane potential
relationship: never_in_taxon NCBITaxon:4895
[Term]
id: GO:0001525
name: angiogenesis
def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels." [ISBN:0878932453]
synonym: "blood vessel formation from pre-existing blood vessels" EXACT systematic_synonym []
xref: Wikipedia:Angiogenesis
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0001981 ! results in formation of anatomical entity blood vessel
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0048514 ! blood vessel morphogenesis
relationship: RO:0002297 UBERON:0001981 ! results in formation of anatomical entity blood vessel
[Term]
id: GO:0001539
name: cilium or flagellum-dependent cell motility
def: "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella." [GOC:cilia, GOC:hjd, GOC:krc]
comment: Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent, while the bacterial- and archaeal-type flagella have a different structure. The former are microtubule-based structures that lash back and forth and are present only in eukaryotes, while the latter achieve motility by rotation. Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. These three structures never co-exist in the same organism. Therefore, GO:0001539 'cilium or flagellum-dependent cell motility' is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term. Direct annotations to GO:0001539 'cilium or flagellum-dependent cell motility' may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "ciliary or bacterial-type flagellar motility" RELATED []
synonym: "ciliary/flagellar motility" EXACT []
is_a: GO:0048870 ! cell motility
relationship: never_in_taxon NCBITaxon:4890
[Term]
id: GO:0001541
name: ovarian follicle development
def: "The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure." [https://www.ncbi.nlm.nih.gov/books/NBK279054/]
synonym: "follicular phase" RELATED []
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001305 ! results in development of ovarian follicle
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0008585 ! female gonad development
relationship: RO:0002296 UBERON:0001305 ! results in development of ovarian follicle
[Term]
id: GO:0001545
name: primary ovarian follicle growth
def: "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle)." [GOC:mtg_mpo, https://www.ncbi.nlm.nih.gov/books/NBK279054/]
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0048589 ! developmental growth
intersection_of: GO:0040007 ! growth
intersection_of: RO:0002343 UBERON:0000035 ! results in growth of primary ovarian follicle
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0001541 ! ovarian follicle development
relationship: RO:0002343 UBERON:0000035 ! results in growth of primary ovarian follicle
[Term]
id: GO:0001546
name: preantral ovarian follicle growth
def: "Increase in size of follicles surrounded by two or more layers of granulosa cells up to the onset of antrum formation." [https://www.ncbi.nlm.nih.gov/books/NBK279054/]
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0048589 ! developmental growth
intersection_of: GO:0040007 ! growth
intersection_of: RO:0002343 UBERON:0000036 ! results in growth of secondary ovarian follicle
relationship: in_taxon NCBITaxon:40674 ! Mammalia
relationship: part_of GO:0001541 ! ovarian follicle development
relationship: part_of GO:0048162 ! multi-layer follicle stage
relationship: RO:0002343 UBERON:0000036 ! results in growth of secondary ovarian follicle
[Term]
id: GO:0001547
name: antral ovarian follicle growth
def: "Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity." [https://www.ncbi.nlm.nih.gov/books/NBK279054/]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0048589 ! developmental growth
intersection_of: GO:0040007 ! growth
intersection_of: RO:0002343 UBERON:0000037 ! results in growth of tertiary ovarian follicle
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0001541 ! ovarian follicle development
relationship: RO:0002343 UBERON:0000037 ! results in growth of tertiary ovarian follicle
[Term]
id: GO:0001550
name: ovarian cumulus expansion
def: "Increase in size of the cumulus surrounding the oocyte including change in morphology due to proliferation and dispersion of cumulus cells." [PMID:30010832]
synonym: "ovarian cumulus growth" RELATED []
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0048589 ! developmental growth
intersection_of: GO:0040007 ! growth
intersection_of: RO:0002343 UBERON:0001306 ! results in growth of cumulus oophorus
relationship: in_taxon NCBITaxon:40674 ! Mammalia
relationship: part_of GO:0001547 ! antral ovarian follicle growth
relationship: part_of GO:0048165 ! fused antrum stage
relationship: RO:0002343 UBERON:0001306 ! results in growth of cumulus oophorus
[Term]
id: GO:0001553
name: luteinization
def: "The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation." [https://www.ncbi.nlm.nih.gov/books/NBK279054/]
synonym: "luteal phase" RELATED []
xref: Wikipedia:Luteal_phase
xref: Wikipedia:Luteinization
is_a: GO:0022602 ! ovulation cycle process
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: part_of GO:0008585 ! female gonad development
[Term]
id: GO:0001555
name: oocyte growth
def: "The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [https://www.ncbi.nlm.nih.gov/books/NBK279054/]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048588 ! developmental cell growth
intersection_of: GO:0040007 ! growth
intersection_of: RO:0002343 CL:0000023 ! results in growth of oocyte
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: part_of GO:0048599 ! oocyte development
relationship: RO:0002343 CL:0000023 ! results in growth of oocyte
[Term]
id: GO:0001556
name: oocyte maturation
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization." [GOC:devbiol, https://www.ncbi.nlm.nih.gov/books/NBK279054/]
xref: Wikipedia:Oocyte_maturation
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048469 ! cell maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 CL:0000023 ! results in maturation of oocyte
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: part_of GO:0048599 ! oocyte development
relationship: RO:0002299 CL:0000023 ! results in maturation of oocyte
[Term]
id: GO:0001558
name: regulation of cell growth
def: "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
is_a: GO:0040008 ! regulation of growth
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0016049 ! regulates (processual) cell growth
relationship: in_taxon NCBITaxon:131567 ! cellular organism
relationship: RO:0002211 GO:0016049 ! regulates (processual) cell growth
[Term]
id: GO:0001560
name: regulation of cell growth by extracellular stimulus
def: "Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph]
synonym: "interpretation of external signals that regulate cell growth" EXACT []
synonym: "regulation of cell growth by detection of exogenous stimulus" EXACT []
synonym: "regulation of cell growth by sensing of exogenous stimulus" EXACT []
synonym: "regulation of growth by exogenous signal" EXACT []
synonym: "regulation of growth by exogenous stimuli" EXACT []
synonym: "regulation of growth by exogenous stimulus" EXACT []
synonym: "regulation of growth by external signal" EXACT []
synonym: "regulation of growth by external stimuli" EXACT []
synonym: "regulation of growth by external stimulus" EXACT []
is_a: GO:0001558 ! regulation of cell growth
intersection_of: GO:0001558 ! regulation of cell growth
intersection_of: part_of GO:0051716 ! cellular response to stimulus
relationship: in_taxon NCBITaxon:131567 ! cellular organism
relationship: part_of GO:0051716 ! cellular response to stimulus
[Term]
id: GO:0001568
name: blood vessel development
def: "The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood." [GOC:hjd, UBERON:0001981]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001981 ! results in development of blood vessel
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0001944 ! vasculature development
relationship: RO:0002296 UBERON:0001981 ! results in development of blood vessel
[Term]
id: GO:0001569
name: branching involved in blood vessel morphogenesis
def: "The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system." [GOC:dph]
synonym: "patterning of blood vessels" BROAD [GOC:dph]
is_a: GO:0048754 ! branching morphogenesis of an epithelial tube
intersection_of: GO:0048754 ! branching morphogenesis of an epithelial tube
intersection_of: part_of GO:0048514 ! blood vessel morphogenesis
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0001525 ! angiogenesis
relationship: part_of GO:0048514 ! blood vessel morphogenesis
[Term]
id: GO:0001570
name: vasculogenesis
def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes." [PMID:8999798]
synonym: "vascular morphogenesis" EXACT []
xref: Wikipedia:Vasculogenesis
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002297 UBERON:0001981 ! results in formation of anatomical entity blood vessel
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0048514 ! blood vessel morphogenesis
relationship: RO:0002297 UBERON:0001981 ! results in formation of anatomical entity blood vessel
[Term]
id: GO:0001578
name: microtubule bundle formation
def: "A process that results in a parallel arrangement of microtubules." [GOC:dph]
synonym: "microtubule bundling" EXACT []
is_a: GO:0000226 ! microtubule cytoskeleton organization
relationship: in_taxon NCBITaxon:131567 ! cellular organism
relationship: RO:0000057 GO:0005874 ! has participant microtubule
relationship: RO:0002297 GO:0097427 ! results in formation of anatomical entity microtubule bundle
[Term]
id: GO:0001609
name: G protein-coupled adenosine receptor activity
alt_id: GO:0001610
alt_id: GO:0001611
alt_id: GO:0001612
alt_id: GO:0001613
alt_id: GO:0008501
def: "Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:mah, PMID:9755289]
synonym: "A1 adenosine receptor activity, G protein coupled" NARROW []
synonym: "A1 adenosine receptor activity, G-protein coupled" NARROW []
synonym: "A2A adenosine receptor activity, G protein coupled" NARROW []
synonym: "A2A adenosine receptor activity, G-protein coupled" NARROW []
synonym: "A2B adenosine receptor activity, G protein coupled" NARROW []
synonym: "A2B adenosine receptor activity, G-protein coupled" NARROW []
synonym: "A3 adenosine receptor activity, G protein coupled" NARROW []
synonym: "A3 adenosine receptor activity, G-protein coupled" NARROW []
synonym: "adenosine nucleotide receptor" BROAD []
synonym: "adenosine receptor activity, G protein coupled" EXACT []
synonym: "adenosine receptor activity, G-protein coupled" EXACT [GOC:bf]
synonym: "G protein coupled A1 adenosine receptor activity" NARROW []
synonym: "G protein coupled A2A adenosine receptor activity" NARROW []
synonym: "G protein coupled A2B adenosine receptor activity" NARROW []
synonym: "G protein coupled A3 adenosine receptor activity" NARROW []
synonym: "G protein coupled adenosine receptor activity" EXACT []
synonym: "G-protein coupled adenosine receptor activity" EXACT []
synonym: "G-protein-coupled A1 adenosine receptor activity" NARROW []
synonym: "G-protein-coupled A2A adenosine receptor activity" NARROW []
synonym: "G-protein-coupled A2B adenosine receptor activity" NARROW []
synonym: "G-protein-coupled A3 adenosine receptor activity" NARROW []
synonym: "P1 receptor" EXACT [PMID:9755289]
is_a: GO:0004930 ! G protein-coupled receptor activity
intersection_of: GO:0004930 ! G protein-coupled receptor activity
intersection_of: RO:0004009 CHEBI:16335 ! has primary input adenosine
relationship: part_of GO:0001973 ! G protein-coupled adenosine receptor signaling pathway
relationship: RO:0004009 CHEBI:16335 ! has primary input adenosine
[Term]
id: GO:0001614
name: purinergic nucleotide receptor activity
alt_id: GO:0035586
def: "Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling]
synonym: "P2 receptor" RELATED [PMID:9755289]
synonym: "purinergic receptor activity" RELATED []
synonym: "purinoceptor" EXACT [PMID:9755289]
synonym: "purinoreceptor" EXACT [PMID:9755289]
is_a: GO:0016502 ! nucleotide receptor activity
intersection_of: GO:0038023 ! signaling receptor activity
intersection_of: RO:0004009 CHEBI:26395 ! has primary input purine nucleotide
relationship: has_part GO:0017076 ! purine nucleotide binding
relationship: part_of GO:0035590 ! purinergic nucleotide receptor signaling pathway
relationship: RO:0004009 CHEBI:26395 ! has primary input purine nucleotide
created_by: bf
creation_date: 2010-10-22T10:57:12Z
[Term]
id: GO:0001621
name: G protein-coupled ADP receptor activity
alt_id: GO:0045032
def: "Combining with ADP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:mah, GOC:signaling, PMID:11196645]
synonym: "ADP receptor activity" BROAD []
synonym: "ADP-activated adenosine receptor activity" RELATED []
synonym: "ADP-activated nucleotide receptor activity" BROAD []
synonym: "K101 receptor" NARROW []
synonym: "platelet ADP receptor activity" NARROW [GOC:mah]
is_a: GO:0045028 ! G protein-coupled purinergic nucleotide receptor activity
intersection_of: GO:0004930 ! G protein-coupled receptor activity
intersection_of: RO:0004009 CHEBI:456216 ! has primary input ADP(3-)
relationship: has_part GO:0043531 ! ADP binding
relationship: RO:0004009 CHEBI:456216 ! has primary input ADP(3-)
[Term]
id: GO:0001649
name: osteoblast differentiation
def: "The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone." [CL:0000062, GO_REF:0000034, GOC:jid]
synonym: "osteoblast cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000062 ! results in acquisition of features of osteoblast
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0001503 ! ossification
relationship: RO:0002315 CL:0000062 ! results in acquisition of features of osteoblast
[Term]
id: GO:0001653
name: peptide receptor activity
def: "Combining with an extracellular or intracellular peptide to initiate a change in cell activity." [GOC:jl]
synonym: "endogenous peptide receptor activity" NARROW []
synonym: "exogenous peptide receptor activity" NARROW []
is_a: GO:0038023 ! signaling receptor activity
intersection_of: GO:0038023 ! signaling receptor activity
intersection_of: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion
relationship: has_part GO:0042277 ! peptide binding
relationship: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion
[Term]
id: GO:0001654
name: eye development
alt_id: GO:0042460
def: "The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl]
xref: Wikipedia:Eye_development
is_a: GO:0007423 ! sensory organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000970 ! results in development of eye
relationship: in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of GO:0150063 ! visual system development
relationship: RO:0002296 UBERON:0000970 ! results in development of eye
[Term]
id: GO:0001655
name: urogenital system development
def: "The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0004122 ! results in development of genitourinary system
relationship: has_part GO:0072001 ! renal system development
relationship: in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: RO:0002296 UBERON:0004122 ! results in development of genitourinary system
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/22178" xsd:anyURI
[Term]
id: GO:0001656
name: metanephros development
def: "The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:bf, ISBN:0192800752]
is_a: GO:0001822 ! kidney development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000081 ! results in development of metanephros
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: RO:0002296 UBERON:0000081 ! results in development of metanephros
[Term]
id: GO:0001657
name: ureteric bud development
def: "The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0072164 ! mesonephric tubule development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000084 ! results in development of ureteric bud
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: RO:0002296 UBERON:0000084 ! results in development of ureteric bud
[Term]
id: GO:0001658
name: branching involved in ureteric bud morphogenesis
def: "The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, PMID:16916378]
synonym: "ureteric bud branching" EXACT [GOC:dph]
is_a: GO:0048754 ! branching morphogenesis of an epithelial tube
intersection_of: GO:0001763 ! morphogenesis of a branching structure
intersection_of: part_of GO:0060675 ! ureteric bud morphogenesis
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: part_of GO:0060675 ! ureteric bud morphogenesis
[Term]
id: GO:0001659
name: temperature homeostasis
def: "A homeostatic process in which an organism modulates its internal body temperature." [GOC:jl]
synonym: "thermoregulation" EXACT [GOC:dph, GOC:tb]
xref: Wikipedia:Thermoregulation
is_a: GO:0048871 ! multicellular organismal-level homeostasis
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
[Term]
id: GO:0001664
name: G protein-coupled receptor binding
def: "Binding to a G protein-coupled receptor." [GOC:ceb, GOC:dph]
synonym: "G protein coupled receptor binding" EXACT []
synonym: "G protein coupled receptor ligand" NARROW []
synonym: "G-protein coupled receptor binding" EXACT [GOC:bf]
synonym: "G-protein-coupled receptor ligand" NARROW []
xref: Reactome:R-HSA-500717 "Activation of GRIK3 homomer"
is_a: GO:0005102 ! signaling receptor binding
[Term]
id: GO:0001666
name: response to hypoxia
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
comment: Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%.
synonym: "response to hypoxic stress" EXACT []
synonym: "response to intermittent hypoxia" NARROW []
synonym: "response to lowered oxygen tension" EXACT []
synonym: "response to sustained hypoxia" NARROW []
is_a: GO:0006950 ! response to stress
is_a: GO:0036293 ! response to decreased oxygen levels
[Term]
id: GO:0001667
name: ameboidal-type cell migration
def: "Cell migration that is accomplished by extension and retraction of a pseudopodium." [GOC:dph]
comment: Note that this term refers to a mode of migration rather than to any particular cell type.
synonym: "ameboid cell migration" EXACT []
synonym: "amoeboid cell migration" EXACT []
synonym: "amoeboidal cell migration" EXACT []
is_a: GO:0016477 ! cell migration
relationship: never_in_taxon NCBITaxon:4890
[Term]
id: GO:0001669
name: acrosomal vesicle
def: "A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome." [ISBN:0124325653, ISBN:0198506732]
synonym: "acrosomal granule" EXACT [GOC:sart]
synonym: "acrosome" EXACT [GOC:dph]
xref: Wikipedia:Acrosome
is_a: GO:0030141 ! secretory granule
relationship: in_taxon NCBITaxon:2759 ! Eukaryota
relationship: never_in_taxon NCBITaxon:3176
relationship: never_in_taxon NCBITaxon:3378
relationship: never_in_taxon NCBITaxon:3398
relationship: never_in_taxon NCBITaxon:4751 ! Fungi
relationship: never_in_taxon NCBITaxon:5782
relationship: part_of CL:0000019 ! sperm
[Term]
id: GO:0001673
name: male germ cell nucleus
alt_id: GO:0043081
def: "The nucleus of a male germ cell, a reproductive cell in males." [CL:0000015, GOC:hjd, GOC:mtg_sensu]
synonym: "male germ-cell nucleus" EXACT []
is_a: GO:0043073 ! germ cell nucleus
intersection_of: GO:0005634 ! nucleus
intersection_of: part_of CL:0000015 ! male germ cell
relationship: in_taxon NCBITaxon:2759 ! Eukaryota
relationship: part_of CL:0000015 ! male germ cell
[Term]
id: GO:0001674
name: female germ cell nucleus
alt_id: GO:0043080
def: "The nucleus of the female germ cell, a reproductive cell in females." [CL:0000021, GOC:hjd]
synonym: "female germ-cell nucleus" EXACT []
is_a: GO:0043073 ! germ cell nucleus
intersection_of: GO:0005634 ! nucleus
intersection_of: part_of CL:0000021 ! female germ cell
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: part_of CL:0000021 ! female germ cell
[Term]
id: GO:0001675
name: acrosome assembly
def: "The formation of the acrosome from the spermatid Golgi." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "acrosome formation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0033363 ! secretory granule organization
is_a: GO:0070925 ! organelle assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0001669 ! results in assembly of acrosomal vesicle
relationship: in_taxon NCBITaxon:2759 ! Eukaryota
relationship: never_in_taxon NCBITaxon:3176
relationship: never_in_taxon NCBITaxon:3378
relationship: never_in_taxon NCBITaxon:3398
relationship: never_in_taxon NCBITaxon:4751 ! Fungi
relationship: never_in_taxon NCBITaxon:5782
relationship: part_of GO:0007286 ! spermatid development
relationship: RO:0002588 GO:0001669 ! results in assembly of acrosomal vesicle
[Term]
id: GO:0001677
name: formation of translation initiation ternary complex
def: "Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:hjd]
synonym: "translation initiation ternary complex assembly" EXACT []
is_a: GO:0022618 ! protein-RNA complex assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0044207 ! results in assembly of translation initiation ternary complex
relationship: in_taxon NCBITaxon:131567 ! cellular organism
relationship: part_of GO:0006413 ! translational initiation
relationship: RO:0002588 GO:0044207 ! results in assembly of translation initiation ternary complex
[Term]
id: GO:0001678
name: intracellular glucose homeostasis
def: "A homeostatic process involved in the maintenance of a steady state level of glucose within a cell." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "cell glucose homeostasis" EXACT [GOC:dph, GOC:tb]
synonym: "cellular glucose homeostasis" EXACT []
is_a: GO:0042593 ! glucose homeostasis
is_a: GO:0055082 ! intracellular chemical homeostasis
intersection_of: GO:0019725 ! cellular homeostasis
intersection_of: RO:0002332 CHEBI:4167 ! regulates levels of D-glucopyranose
relationship: in_taxon NCBITaxon:131567 ! cellular organism
relationship: RO:0002332 CHEBI:4167 ! regulates levels of D-glucopyranose
[Term]
id: GO:0001692
name: histamine metabolic process
def: "The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172]
synonym: "histamine metabolism" EXACT []
is_a: GO:0006576 ! biogenic amine metabolic process
is_a: GO:0052803 ! imidazole-containing compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:58432 ! has primary input or output histaminium
relationship: RO:0004007 CHEBI:58432 ! has primary input or output histaminium
[Term]
id: GO:0001694
name: histamine biosynthetic process
alt_id: GO:0001693
def: "The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172]
synonym: "histamine anabolism" EXACT []
synonym: "histamine biosynthesis" EXACT []
synonym: "histamine formation" EXACT []
synonym: "histamine synthesis" EXACT []
is_a: GO:0001692 ! histamine metabolic process
is_a: GO:0042401 ! biogenic amine biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:58432 ! has primary output histaminium
relationship: RO:0004008 CHEBI:58432 ! has primary output histaminium
[Term]
id: GO:0001695
name: histamine catabolic process
def: "The chemical reactions and pathways resulting in the breakdown of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172]
synonym: "histamine breakdown" EXACT []
synonym: "histamine catabolism" EXACT []
synonym: "histamine degradation" EXACT []
is_a: GO:0001692 ! histamine metabolic process
is_a: GO:0042402 ! biogenic amine catabolic process
is_a: GO:0052805 ! imidazole-containing compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:58432 ! has primary input histaminium
relationship: RO:0004009 CHEBI:58432 ! has primary input histaminium
[Term]
id: GO:0001696
name: gastric acid secretion
def: "The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:hjd]
synonym: "hydrochloric acid secretion" NARROW []
is_a: GO:0022600 ! digestive system process
is_a: GO:0046717 ! acid secretion
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
[Term]
id: GO:0001700
name: embryonic development via the syncytial blastoderm
def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0009792 ! embryo development ending in birth or egg hatching
relationship: in_taxon NCBITaxon:50557 ! Insecta
[Term]
id: GO:0001701
name: in utero embryonic development
def: "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0043009 ! chordate embryonic development
relationship: in_taxon NCBITaxon:32525 ! Theria
[Term]
id: GO:0001702
name: gastrulation with mouth forming second
alt_id: GO:0010003
alt_id: GO:0048276
def: "A gastrulation process in which the initial invagination becomes the anus and the mouth forms second." [GOC:go_curators, GOC:mtg_sensu]
synonym: "deuterostomic gastrulation" EXACT [GOC:dph]
is_a: GO:0007369 ! gastrulation
relationship: in_taxon NCBITaxon:33511 ! Deuterostomia
[Term]
id: GO:0001703
name: gastrulation with mouth forming first
def: "A gastrulation process in which the initial invagination becomes the mouth and the anus forms second." [GOC:go_curators, GOC:mtg_sensu]
synonym: "protostomic gastrulation" NARROW [GOC:dph]
is_a: GO:0007369 ! gastrulation
relationship: in_taxon NCBITaxon:33317 ! Protostomia
[Term]
id: GO:0001704
name: formation of primary germ layer
def: "The formation of the ectoderm, mesoderm and endoderm during gastrulation." [GOC:go_curators]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0000923 ! results in formation of anatomical entity germ layer
relationship: in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of GO:0007369 ! gastrulation
relationship: RO:0002297 UBERON:0000923 ! results in formation of anatomical entity germ layer
[Term]
id: GO:0001705
name: ectoderm formation
def: "The formation of ectoderm during gastrulation." [GOC:go_curators]
is_a: GO:0001704 ! formation of primary germ layer
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0000924 ! results in formation of anatomical entity ectoderm
relationship: in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of GO:0007398 ! ectoderm development
relationship: RO:0002297 UBERON:0000924 ! results in formation of anatomical entity ectoderm
[Term]
id: GO:0001706
name: endoderm formation
def: "The formation of the endoderm during gastrulation." [GOC:go_curators]
synonym: "endoblast formation" NARROW [GOC:dph, GOC:sdb_2009, GOC:tb]
xref: Reactome:R-HSA-9823730 "Formation of definitive endoderm"
is_a: GO:0001704 ! formation of primary germ layer
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0000925 ! results in formation of anatomical entity endoderm
relationship: in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of GO:0007492 ! endoderm development
relationship: RO:0002297 UBERON:0000925 ! results in formation of anatomical entity endoderm
[Term]
id: GO:0001707
name: mesoderm formation
def: "The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:go_curators]
is_a: GO:0001704 ! formation of primary germ layer
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0000926 ! results in formation of anatomical entity mesoderm
relationship: in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of GO:0048332 ! mesoderm morphogenesis
relationship: RO:0002297 UBERON:0000926 ! results in formation of anatomical entity mesoderm
[Term]
id: GO:0001738
name: morphogenesis of a polarized epithelium
def: "The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:dph]
synonym: "epithelial polarization" EXACT [GOC:dph]
is_a: GO:0002009 ! morphogenesis of an epithelium
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0010137 ! results in morphogenesis of polarized epithelium
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: RO:0002298 UBERON:0010137 ! results in morphogenesis of polarized epithelium
[Term]
id: GO:0001743
name: lens placode formation
def: "The initial developmental process that will lead to the formation of an eye." [GOC:dph]
synonym: "optic placode formation" RELATED []
is_a: GO:0060788 ! ectodermal placode formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0003073 ! results in formation of anatomical entity lens placode
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0048598 ! embryonic morphogenesis
relationship: RO:0002297 UBERON:0003073 ! results in formation of anatomical entity lens placode
[Term]
id: GO:0001744
name: insect visual primordium formation
alt_id: GO:0007457
def: "Establishment of the optic lobe placode. In Drosophila, for example, the placode appears in the dorsolateral region of the head in late stage 11 embryos and is the precursor to the larval visual system." [GOC:mtg_sensu, PMID:8402833]
synonym: "optic lobe and Bolwig's organ precursor formation" EXACT []
synonym: "optic lobe placode formation" EXACT []
is_a: GO:0060788 ! ectodermal placode formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:6001059 ! results in formation of anatomical entity insect visual primordium
relationship: in_taxon NCBITaxon:50557 ! Insecta
relationship: part_of GO:0001748 ! insect visual primordium development
relationship: RO:0002297 UBERON:6001059 ! results in formation of anatomical entity insect visual primordium
[Term]
id: GO:0001745
name: compound eye morphogenesis
def: "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
synonym: "insect-type retina morphogenesis" EXACT [PMID:11735386]
is_a: GO:0048592 ! eye morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0000018 ! results in morphogenesis of compound eye
relationship: in_taxon NCBITaxon:6656 ! Arthropoda
relationship: part_of GO:0048749 ! compound eye development
relationship: RO:0002298 UBERON:0000018 ! results in morphogenesis of compound eye
[Term]
id: GO:0001748
name: insect visual primordium development
alt_id: GO:0048049
def: "The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig's organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8402833]
synonym: "optic lobe and Bolwig's organ precursor development" EXACT []
synonym: "optic lobe placode development" EXACT []
synonym: "optic placode development" BROAD []
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:6001059 ! results in development of insect visual primordium
relationship: in_taxon NCBITaxon:50557 ! Insecta
relationship: RO:0002296 UBERON:6001059 ! results in development of insect visual primordium
[Term]
id: GO:0001750
name: photoreceptor outer segment
def: "The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins." [GOC:cilia, GOC:krc, GOC:pde, ISBN:0824072820, PMID:19501669, PMID:26574505, PMID:6771304]
is_a: GO:0110165 ! cellular anatomical entity
relationship: in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of GO:0097733 ! photoreceptor cell cilium
[Term]
id: GO:0001751
name: compound eye photoreceptor cell differentiation
def: "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators]
is_a: GO:0001754 ! eye photoreceptor cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:2000019 ! results in acquisition of features of compound eye photoreceptor cell
relationship: in_taxon NCBITaxon:6656 ! Arthropoda
relationship: part_of GO:0001745 ! compound eye morphogenesis
relationship: RO:0002315 CL:2000019 ! results in acquisition of features of compound eye photoreceptor cell
[Term]
id: GO:0001754
name: eye photoreceptor cell differentiation
def: "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms." [GOC:go_curators]
is_a: GO:0046530 ! photoreceptor cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000287 ! results in acquisition of features of eye photoreceptor cell
relationship: in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of GO:0048592 ! eye morphogenesis
relationship: RO:0002315 CL:0000287 ! results in acquisition of features of eye photoreceptor cell
[Term]
id: GO:0001755
name: neural crest cell migration
def: "The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo." [GOC:ascb_2009, GOC:dph, GOC:tb, ISBN:0878932437]
is_a: GO:0090497 ! mesenchymal cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000333 ! results in movement of migratory neural crest cell
relationship: in_taxon NCBITaxon:89593 ! Craniata
relationship: part_of GO:0014032 ! neural crest cell development
relationship: RO:0002565 CL:0000333 ! results in movement of migratory neural crest cell
[Term]
id: GO:0001756
name: somitogenesis
def: "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [ISBN:0721662544]
synonym: "formation of mesodermal clusters" EXACT systematic_synonym []
xref: Reactome:R-HSA-9824272 "Somitogenesis"
xref: Wikipedia:Somitogenesis
is_a: GO:0009952 ! anterior/posterior pattern specification
is_a: GO:0035282 ! segmentation
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0002329 ! results in formation of anatomical entity somite
relationship: in_taxon NCBITaxon:7711 ! Chordata
relationship: part_of GO:0043009 ! chordate embryonic development
relationship: part_of GO:0061053 ! somite development
relationship: RO:0002297 UBERON:0002329 ! results in formation of anatomical entity somite
[Term]
id: GO:0001763
name: morphogenesis of a branching structure
def: "The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes." [ISBN:0721662544]
synonym: "branching morphogenesis" EXACT [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0032501 ! multicellular organismal process
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
[Term]
id: GO:0001764
name: neuron migration
def: "The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [CL:0000540, GOC:go_curators]
synonym: "neuron chemotaxis" EXACT []
synonym: "neuron guidance" RELATED []
synonym: "neuronal migration" EXACT []
xref: Wikipedia:Neural_development#Neuron_migration
xref: Wikipedia:Neuron_migration
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000540 ! results in movement of neuron
relationship: in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of GO:0048699 ! generation of neurons
relationship: RO:0002565 CL:0000540 ! results in movement of neuron
[Term]
id: GO:0001767
name: establishment of lymphocyte polarity
def: "The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889]
synonym: "lymphocyte polarization" EXACT []
is_a: GO:0030010 ! establishment of cell polarity
intersection_of: GO:0030010 ! establishment of cell polarity
intersection_of: BFO:0000066 CL:0000542 ! occurs in lymphocyte
relationship: BFO:0000066 CL:0000542 ! occurs in lymphocyte
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0046649 ! lymphocyte activation
[Term]
id: GO:0001768
name: establishment of T cell polarity
def: "The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889]
synonym: "establishment of T lymphocyte polarity" EXACT []
synonym: "establishment of T-cell polarity" EXACT []
synonym: "establishment of T-lymphocyte polarity" EXACT []
synonym: "T cell polarization" EXACT []
synonym: "T lymphocyte polarization" EXACT []
synonym: "T-cell polarization" EXACT []
is_a: GO:0001767 ! establishment of lymphocyte polarity
intersection_of: GO:0030010 ! establishment of cell polarity
intersection_of: BFO:0000066 CL:0000084 ! occurs in T cell
relationship: BFO:0000066 CL:0000084 ! occurs in T cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0042110 ! T cell activation
[Term]
id: GO:0001769
name: establishment of B cell polarity
def: "The directed orientation of B cell signaling molecules and associated membrane rafts towards a chemokine gradient of a contact point with an antigen displaying cell." [GOC:mgi_curators, PMID:12615889, PMID:9692889]
comment: Note that 'antigen displaying cell' in this term encompasses cell types such as follicular dendritic cells which display the unprocessed antigens of a B cell, leading to activation of the B cells and antigen uptake and processing by the B cells.
synonym: "B cell polarization" EXACT []
synonym: "B lymphocyte polarization" EXACT []
synonym: "B-cell polarization" EXACT []
synonym: "establishment of B lymphocyte polarity" EXACT []
synonym: "establishment of B-cell polarity" EXACT []
synonym: "establishment of B-lymphocyte polarity" EXACT []
is_a: GO:0001767 ! establishment of lymphocyte polarity
intersection_of: GO:0030010 ! establishment of cell polarity
intersection_of: BFO:0000066 CL:0000236 ! occurs in B cell
relationship: BFO:0000066 CL:0000236 ! occurs in B cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0042113 ! B cell activation
[Term]
id: GO:0001770
name: establishment of natural killer cell polarity
def: "The directed orientation of natural killer cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with a cell displaying natural killer cell activating ligands." [GOC:mgi_curators, PMID:12615886, PMID:9759849]
synonym: "establishment of NK cell polarity" EXACT []
synonym: "natural killer cell polarization" EXACT []
synonym: "NK cell polarization" EXACT []
is_a: GO:0001767 ! establishment of lymphocyte polarity
intersection_of: GO:0030010 ! establishment of cell polarity
intersection_of: BFO:0000066 CL:0000623 ! occurs in natural killer cell
relationship: BFO:0000066 CL:0000623 ! occurs in natural killer cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0030101 ! natural killer cell activation
[Term]
id: GO:0001773
name: myeloid dendritic cell activation
def: "The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149]
is_a: GO:0002274 ! myeloid leukocyte activation
intersection_of: GO:0001775 ! cell activation
intersection_of: RO:0004009 CL:0000782 ! has primary input myeloid dendritic cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0004009 CL:0000782 ! has primary input myeloid dendritic cell
[Term]
id: GO:0001775
name: cell activation
def: "A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators]
subset: goslim_pir
is_a: GO:0009987 ! cellular process
is_a: GO:0032501 ! multicellular organismal process
relationship: in_taxon NCBITaxon:33208 ! Metazoa
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24416" xsd:anyURI
[Term]
id: GO:0001776
name: leukocyte homeostasis
def: "The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149]
comment: Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus.
synonym: "immune cell homeostasis" EXACT []
synonym: "leucocyte homeostasis" EXACT []
is_a: GO:0002376 ! immune system process
is_a: GO:0048872 ! homeostasis of number of cells
intersection_of: GO:0048872 ! homeostasis of number of cells
intersection_of: RO:0012003 CL:0000738 ! acts on population of leukocyte
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0012003 CL:0000738 ! acts on population of leukocyte
[Term]
id: GO:0001777
name: T cell homeostatic proliferation
def: "The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus." [GOC:mgi_curators, ISBN:0781735149]
synonym: "resting T cell proliferation" EXACT []
synonym: "resting T-cell proliferation" EXACT []
synonym: "T lymphocyte homeostatic proliferation" EXACT []
synonym: "T-cell homeostatic proliferation" EXACT []
synonym: "T-lymphocyte homeostatic proliferation" EXACT []
is_a: GO:0042098 ! T cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: part_of GO:0042592 ! homeostatic process
intersection_of: RO:0012003 CL:0000084 ! acts on population of T cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0042592 ! homeostatic process
relationship: part_of GO:0043029 ! T cell homeostasis
relationship: RO:0012003 CL:0000084 ! acts on population of T cell
[Term]
id: GO:0001779
name: natural killer cell differentiation
def: "The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "natural killer cell development" RELATED [GOC:add]
synonym: "NK cell differentiation" EXACT []
is_a: GO:0030098 ! lymphocyte differentiation
is_a: GO:0030101 ! natural killer cell activation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000623 ! results in acquisition of features of natural killer cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002315 CL:0000623 ! results in acquisition of features of natural killer cell
[Term]
id: GO:0001780
name: neutrophil homeostasis
def: "The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, GOC:pr, PMID:12752675, PMID:12960266]
comment: Note that this term represents the return of neutrophil levels to stable numbers following an immune response as well as the proliferation and elimination of neutrophils required to maintain stable numbers in the absence of an outside stimulus.
is_a: GO:0001776 ! leukocyte homeostasis
is_a: GO:0002262 ! myeloid cell homeostasis
intersection_of: GO:0048872 ! homeostasis of number of cells
intersection_of: RO:0012003 CL:0000775 ! acts on population of neutrophil
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0012003 CL:0000775 ! acts on population of neutrophil
[Term]
id: GO:0001781
name: neutrophil apoptotic process
def: "Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." [CL:0000775, GOC:add, GOC:mtg_apoptosis, PMID:12752675, PMID:12960266]
synonym: "apoptosis of neutrophils" EXACT []
synonym: "neutrophil apoptosis" NARROW []
synonym: "neutrophil programmed cell death by apoptosis" EXACT []
synonym: "programmed cell death of neutrophils by apoptosis" EXACT []
synonym: "programmed cell death, neutrophils" EXACT []
is_a: GO:0006925 ! inflammatory cell apoptotic process
is_a: GO:0033028 ! myeloid cell apoptotic process
is_a: GO:0071887 ! leukocyte apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000066 CL:0000775 ! occurs in neutrophil
relationship: BFO:0000066 CL:0000775 ! occurs in neutrophil
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0001780 ! neutrophil homeostasis
[Term]
id: GO:0001782
name: B cell homeostasis
def: "The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149, PMID:12956429]
comment: Note that this term represents the return of B cell levels to stable numbers following an immune response as well as the proliferation and elimination of B cells required to maintain stable numbers in the absence of an outside stimulus.
synonym: "B lymphocyte homeostasis" EXACT []
synonym: "B-cell homeostasis" EXACT []
synonym: "B-lymphocyte homeostasis" EXACT []
is_a: GO:0002260 ! lymphocyte homeostasis
intersection_of: GO:0048872 ! homeostasis of number of cells
intersection_of: RO:0012003 CL:0000236 ! acts on population of B cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0012003 CL:0000236 ! acts on population of B cell
[Term]
id: GO:0001783
name: B cell apoptotic process
def: "Any apoptotic process in a B cell, a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity." [CL:0000236, GOC:add, GOC:mtg_apoptosis, ISBN:0781735149]
synonym: "apoptosis of B cells" EXACT []
synonym: "apoptosis of B lymphocytes" EXACT []
synonym: "apoptosis of B-cells" EXACT []
synonym: "apoptosis of B-lymphocytes" EXACT []
synonym: "B cell apoptosis" NARROW []
synonym: "B cell programmed cell death by apoptosis" EXACT []
synonym: "B lymphocyte apoptosis" EXACT []
synonym: "B lymphocyte programmed cell death by apoptosis" EXACT []
synonym: "B-cell apoptosis" EXACT []
synonym: "B-cell programmed cell death by apoptosis" EXACT []
synonym: "B-lymphocyte apoptosis" EXACT []
synonym: "B-lymphocyte programmed cell death by apoptosis" EXACT []
synonym: "programmed cell death of B cells by apoptosis" EXACT []
synonym: "programmed cell death of B lymphocytes by apoptosis" EXACT []
synonym: "programmed cell death of B-cells by apoptosis" EXACT []
synonym: "programmed cell death of B-lymphocytes by apoptosis" EXACT []
synonym: "programmed cell death, B cells" EXACT []
synonym: "programmed cell death, B lymphocytes" EXACT []
synonym: "programmed cell death, B-cells" EXACT []
synonym: "programmed cell death, B-lymphocytes" EXACT []
is_a: GO:0070227 ! lymphocyte apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000066 CL:0000236 ! occurs in B cell
relationship: BFO:0000066 CL:0000236 ! occurs in B cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
[Term]
id: GO:0001787
name: natural killer cell proliferation
def: "The expansion of a natural killer cell population by cell division." [GOC:add, ISBN:0781735149]
synonym: "NK cell proliferation" EXACT []
is_a: GO:0030101 ! natural killer cell activation
is_a: GO:0046651 ! lymphocyte proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000623 ! acts on population of natural killer cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0012003 CL:0000623 ! acts on population of natural killer cell
[Term]
id: GO:0001816
name: cytokine production
alt_id: GO:0042032
alt_id: GO:0042089
alt_id: GO:0042107
alt_id: GO:0050663
def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "cytokine biosynthetic process" NARROW []
synonym: "cytokine metabolic process" NARROW []
synonym: "cytokine secretion" NARROW []
synonym: "interferon production" NARROW [GOC:add, GOC:mah]
synonym: "interferon secretion" NARROW [GOC:add, GOC:mah]
synonym: "interleukin production" NARROW [GOC:add, GOC:mah, http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F]
synonym: "interleukin secretion" NARROW [GOC:add, GOC:mah, http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F]
is_a: GO:0010467 ! gene expression
is_a: GO:0032501 ! multicellular organismal process
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/19116" xsd:anyURI
[Term]
id: GO:0001817
name: regulation of cytokine production
alt_id: GO:0042035
alt_id: GO:0050707
def: "Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149]
synonym: "regulation of cytokine anabolism" EXACT []
synonym: "regulation of cytokine biosynthesis" EXACT []
synonym: "regulation of cytokine biosynthetic process" NARROW []
synonym: "regulation of cytokine formation" EXACT []
synonym: "regulation of cytokine secretion" NARROW []
synonym: "regulation of cytokine synthesis" EXACT []
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0001816 ! regulates (processual) cytokine production
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
relationship: RO:0002211 GO:0001816 ! regulates (processual) cytokine production
[Term]
id: GO:0001818
name: negative regulation of cytokine production
alt_id: GO:0042036
alt_id: GO:0050710
def: "Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149]
synonym: "down regulation of cytokine biosynthetic process" EXACT []
synonym: "down regulation of cytokine production" EXACT []
synonym: "down-regulation of cytokine biosynthetic process" EXACT []
synonym: "down-regulation of cytokine production" EXACT []
synonym: "downregulation of cytokine biosynthetic process" EXACT []
synonym: "downregulation of cytokine production" EXACT []
synonym: "inhibition of cytokine biosynthetic process" NARROW []
synonym: "inhibition of cytokine production" NARROW []
synonym: "negative regulation of cytokine anabolism" EXACT []
synonym: "negative regulation of cytokine biosynthesis" EXACT []
synonym: "negative regulation of cytokine biosynthetic process" NARROW []
synonym: "negative regulation of cytokine formation" EXACT []
synonym: "negative regulation of cytokine secretion" NARROW []
synonym: "negative regulation of cytokine synthesis" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0001816 ! negatively regulates cytokine production
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
relationship: RO:0002212 GO:0001816 ! negatively regulates cytokine production
[Term]
id: GO:0001819
name: positive regulation of cytokine production
alt_id: GO:0042108
alt_id: GO:0050715
def: "Any process that activates or increases the frequency, rate or extent of production of a cytokine." [GOC:add, ISBN:0781735149]
synonym: "activation of cytokine production" NARROW []
synonym: "positive regulation of cytokine biosynthetic process" NARROW []
synonym: "positive regulation of cytokine secretion" NARROW []
synonym: "stimulation of cytokine production" NARROW []
synonym: "up regulation of cytokine production" EXACT []
synonym: "up-regulation of cytokine production" EXACT []
synonym: "upregulation of cytokine production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0001816 ! positively regulates cytokine production
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
relationship: RO:0002213 GO:0001816 ! positively regulates cytokine production
[Term]
id: GO:0001820
name: serotonin secretion
def: "The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesized in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells." [GOC:ef, ISBN:0198506732, ISBN:0781735149]
synonym: "5-HT secretion" EXACT []
synonym: "5-hydroxytryptamine secretion" EXACT []
synonym: "serotonin release" RELATED [GOC:tb]
is_a: GO:0006837 ! serotonin transport
is_a: GO:0023061 ! signal release
intersection_of: GO:0046903 ! secretion
intersection_of: RO:0004009 CHEBI:350546 ! has primary input serotonin(1+)
relationship: RO:0004009 CHEBI:350546 ! has primary input serotonin(1+)
[Term]
id: GO:0001821
name: histamine secretion
def: "The regulated release of histamine by a cell or tissue. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems." [GOC:mah, ISBN:0198506732, ISBN:0781735149]
is_a: GO:0046903 ! secretion
is_a: GO:0051608 ! histamine transport
intersection_of: GO:0046903 ! secretion
intersection_of: RO:0004009 CHEBI:58432 ! has primary input histaminium
relationship: RO:0004009 CHEBI:58432 ! has primary input histaminium
[Term]
id: GO:0001822
name: kidney development
def: "The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:mtg_kidney_jan10, ISBN:0124020607, ISBN:0721662544]
synonym: "nephrogenesis" RELATED [GOC:rph]
xref: Reactome:R-HSA-9830369 "Kidney development"
xref: Wikipedia:Kidney_development
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002113 ! results in development of kidney
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: part_of GO:0072001 ! renal system development
relationship: RO:0002296 UBERON:0002113 ! results in development of kidney
[Term]
id: GO:0001823
name: mesonephros development
def: "The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney." [GOC:dph, ISBN:0124020607, ISBN:0721662544, PMID:10535314]
synonym: "Wolffian body development" EXACT [GOC:dph]
is_a: GO:0001822 ! kidney development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000080 ! results in development of mesonephros
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: RO:0002296 UBERON:0000080 ! results in development of mesonephros
[Term]
id: GO:0001824
name: blastocyst development
def: "The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. The blastula follows the morula and precedes the gastrula in the developmental sequence." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'.
synonym: "blastula development" RELATED []
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000358 ! results in development of blastocyst
relationship: in_taxon NCBITaxon:32525 ! Theria
relationship: part_of GO:0001701 ! in utero embryonic development
relationship: RO:0002296 UBERON:0000358 ! results in development of blastocyst
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/29162" xsd:anyURI
[Term]
id: GO:0001825
name: blastocyst formation
def: "The initial formation of a blastocyst from a solid ball of cells known as a morula." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'.
synonym: "blastula formation" RELATED []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0000358 ! results in formation of anatomical entity blastocyst
relationship: in_taxon NCBITaxon:32525 ! Theria
relationship: part_of GO:0001824 ! blastocyst development
relationship: RO:0002297 UBERON:0000358 ! results in formation of anatomical entity blastocyst
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/29162" xsd:anyURI
[Term]
id: GO:0001826
name: inner cell mass cell differentiation
def: "The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'.
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:2000020 ! results in acquisition of features of inner cell mass cell
relationship: in_taxon NCBITaxon:32525 ! Theria
relationship: part_of GO:0001825 ! blastocyst formation
relationship: RO:0002315 CL:2000020 ! results in acquisition of features of inner cell mass cell
[Term]
id: GO:0001829
name: trophectodermal cell differentiation
def: "The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'.
synonym: "trophectoderm cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:1000274 ! results in acquisition of features of trophectodermal cell
relationship: in_taxon NCBITaxon:32525 ! Theria
relationship: part_of GO:0001825 ! blastocyst formation
relationship: RO:0002315 CL:1000274 ! results in acquisition of features of trophectodermal cell
[Term]
id: GO:0001831
name: trophectodermal cellular morphogenesis
def: "The morphogenesis of trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'.
synonym: "trophectoderm cellular morphogenesis" EXACT []
is_a: GO:0000902 ! cell morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 CL:1000274 ! results in morphogenesis of trophectodermal cell
relationship: in_taxon NCBITaxon:32525 ! Theria
relationship: part_of GO:0001829 ! trophectodermal cell differentiation
relationship: RO:0002298 CL:1000274 ! results in morphogenesis of trophectodermal cell
[Term]
id: GO:0001832
name: blastocyst growth
def: "An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'.
synonym: "blastula growth" RELATED []
is_a: GO:0048589 ! developmental growth
intersection_of: GO:0040007 ! growth
intersection_of: RO:0002343 UBERON:0000358 ! results in growth of blastocyst
relationship: in_taxon NCBITaxon:32525 ! Theria
relationship: part_of GO:0001824 ! blastocyst development
relationship: RO:0002343 UBERON:0000358 ! results in growth of blastocyst
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/29162" xsd:anyURI
[Term]
id: GO:0001833
name: inner cell mass cell proliferation
def: "The proliferation of cells in the inner cell mass." [GOC:dph, GOC:isa_complete, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'.
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:2000020 ! acts on population of inner cell mass cell
relationship: in_taxon NCBITaxon:32525 ! Theria
relationship: part_of GO:0001832 ! blastocyst growth
relationship: RO:0012003 CL:2000020 ! acts on population of inner cell mass cell
[Term]
id: GO:0001834
name: trophectodermal cell proliferation
def: "The proliferation of cells in the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'.
synonym: "trophectoderm cell proliferation" EXACT []
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:1000274 ! acts on population of trophectodermal cell
relationship: in_taxon NCBITaxon:32525 ! Theria
relationship: part_of GO:0001832 ! blastocyst growth
relationship: RO:0012003 CL:1000274 ! acts on population of trophectodermal cell
[Term]
id: GO:0001837
name: epithelial to mesenchymal transition
def: "A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, PMID:14701881]
synonym: "EMT" EXACT []
synonym: "epithelial-mesenchymal transition" EXACT []
synonym: "mesenchymal cell differentiation from epithelial cell" EXACT [GOC:BHF, GOC:dph, GOC:rl]
xref: Reactome:R-HSA-9758919 "Epithelial-Mesenchymal Transition (EMT) during gastrulation"
is_a: GO:0048762 ! mesenchymal cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0008019 ! results in acquisition of features of mesenchymal cell
intersection_of: RO:0004009 CL:0000066 ! has primary input epithelial cell
relationship: in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: RO:0002315 CL:0008019 ! results in acquisition of features of mesenchymal cell
relationship: RO:0004009 CL:0000066 ! has primary input epithelial cell
[Term]
id: GO:0001838
name: embryonic epithelial tube formation
def: "The morphogenesis of an embryonic epithelium into a tube-shaped structure." [GOC:dph, ISBN:0824072820]
is_a: GO:0072175 ! epithelial tube formation
relationship: in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of GO:0016331 ! morphogenesis of embryonic epithelium
[Term]
id: GO:0001839
name: neural plate morphogenesis
def: "The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue." [GOC:dph, ISBN:0878932437]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0003075 ! results in morphogenesis of neural plate
relationship: in_taxon NCBITaxon:7711 ! Chordata
relationship: part_of GO:0001840 ! neural plate development
relationship: RO:0002298 UBERON:0003075 ! results in morphogenesis of neural plate
[Term]
id: GO:0001840
name: neural plate development
def: "The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GOC:dph, GOC:ef, ISBN:0878932437, ISBN:0878932585]
is_a: GO:0060429 ! epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0003075 ! results in development of neural plate
relationship: in_taxon NCBITaxon:7711 ! Chordata
relationship: part_of GO:0043009 ! chordate embryonic development
relationship: RO:0002296 UBERON:0003075 ! results in development of neural plate
[Term]
id: GO:0001841
name: neural tube formation
alt_id: GO:0001679
def: "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." [GOC:dph, ISBN:0878932437]
synonym: "neural tube morphogenesis" EXACT [GOC:dph]
synonym: "neurulation" EXACT []
xref: Wikipedia:Neurulation
is_a: GO:0001838 ! embryonic epithelial tube formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0001049 ! results in formation of anatomical entity neural tube
relationship: in_taxon NCBITaxon:7711 ! Chordata
relationship: part_of GO:0021915 ! neural tube development
relationship: RO:0002297 UBERON:0001049 ! results in formation of anatomical entity neural tube
[Term]
id: GO:0001842
name: neural fold formation
def: "The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove." [GOC:dph, ISBN:0878932437]
synonym: "neural groove formation" RELATED [GOC:dph]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
is_a: GO:0060571 ! morphogenesis of an epithelial fold
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0005062 ! results in formation of anatomical entity neural fold
relationship: in_taxon NCBITaxon:7711 ! Chordata
relationship: part_of GO:0014020 ! primary neural tube formation
relationship: RO:0002297 UBERON:0005062 ! results in formation of anatomical entity neural fold
[Term]
id: GO:0001843
name: neural tube closure
def: "The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline." [GOC:dph, ISBN:0878932437]
is_a: GO:0060606 ! tube closure
intersection_of: GO:0060606 ! tube closure
intersection_of: RO:0004009 UBERON:0001049 ! has primary input neural tube
relationship: in_taxon NCBITaxon:7711 ! Chordata
relationship: part_of GO:0014020 ! primary neural tube formation
relationship: RO:0004009 UBERON:0001049 ! has primary input neural tube
[Term]
id: GO:0001873
name: polysaccharide immune receptor activity
def: "Combining with a polysaccharide and transmitting the signal to initiate an innate immune response. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [PMID:14707091]
synonym: "polysaccharide receptor activity" BROAD []
is_a: GO:0038187 ! pattern recognition receptor activity
intersection_of: GO:0038023 ! signaling receptor activity
intersection_of: RO:0004009 CHEBI:18154 ! has primary input polysaccharide
relationship: has_part GO:0030247 ! polysaccharide binding
relationship: RO:0004009 CHEBI:18154 ! has primary input polysaccharide
[Term]
id: GO:0001882
name: nucleoside binding
def: "Binding to a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose." [GOC:hjd]
subset: goslim_pir
is_a: GO:0097367 ! carbohydrate derivative binding
is_a: GO:1901363 ! heterocyclic compound binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:33838 ! has primary input nucleoside
relationship: RO:0004009 CHEBI:33838 ! has primary input nucleoside
[Term]
id: GO:0001883
name: purine nucleoside binding
def: "Binding to a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose." [GOC:hjd]
is_a: GO:0001882 ! nucleoside binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:26394 ! has primary input purine nucleoside
relationship: RO:0004009 CHEBI:26394 ! has primary input purine nucleoside
[Term]
id: GO:0001885
name: endothelial cell development
def: "The progression of an endothelial cell over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0002064 ! epithelial cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000115 ! results in development of endothelial cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0045446 ! endothelial cell differentiation
relationship: RO:0002296 CL:0000115 ! results in development of endothelial cell
[Term]
id: GO:0001886
name: endothelial cell morphogenesis
def: "The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003382 ! epithelial cell morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 CL:0000115 ! results in morphogenesis of endothelial cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0001885 ! endothelial cell development
relationship: RO:0002298 CL:0000115 ! results in morphogenesis of endothelial cell
[Term]
id: GO:0001889
name: liver development
def: "The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes." [GOC:add, ISBN:068340007X]
is_a: GO:0048732 ! gland development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002107 ! results in development of liver
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0061008 ! hepaticobiliary system development
relationship: RO:0002296 UBERON:0002107 ! results in development of liver
[Term]
id: GO:0001890
name: placenta development
def: "The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X]
synonym: "placental development" EXACT []
synonym: "placentation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001987 ! results in development of placenta
relationship: in_taxon NCBITaxon:32525 ! Theria
relationship: RO:0002296 UBERON:0001987 ! results in development of placenta
[Term]
id: GO:0001892
name: embryonic placenta development
def: "The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X]
synonym: "fetal placenta development" EXACT [GOC:dph]
is_a: GO:0048568 ! embryonic organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0007106 ! results in development of chorionic villus
relationship: in_taxon NCBITaxon:32525 ! Theria
relationship: part_of GO:0001701 ! in utero embryonic development
relationship: part_of GO:0001890 ! placenta development
relationship: RO:0002296 UBERON:0007106 ! results in development of chorionic villus
[Term]
id: GO:0001893
name: maternal placenta development
def: "Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X]
synonym: "decidua development" RELATED [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048856 ! anatomical structure development
is_a: GO:0060135 ! maternal process involved in female pregnancy
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002450 ! results in development of decidua
relationship: in_taxon NCBITaxon:32525 ! Theria
relationship: part_of GO:0001890 ! placenta development
relationship: RO:0002296 UBERON:0002450 ! results in development of decidua
[Term]
id: GO:0001894
name: tissue homeostasis
def: "A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:isa_complete]
synonym: "tissue maintenance" NARROW [GOC:add]
is_a: GO:0060249 ! anatomical structure homeostasis
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
relationship: part_of GO:0048871 ! multicellular organismal-level homeostasis
[Term]
id: GO:0001906
name: cell killing
def: "Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." [GOC:add]
subset: goslim_pir
synonym: "necrosis" RELATED []
is_a: GO:0009987 ! cellular process
disjoint_from: GO:0044848 ! biological phase
[Term]
id: GO:0001909
name: leukocyte mediated cytotoxicity
def: "The directed killing of a target cell by a leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149, PMID:11911826]
comment: Note that this term and its children describe contact-dependent killing of target cells by lymphocytes and myeloid cells of the immune system.
synonym: "immune cell mediated cell death" EXACT []
synonym: "immune cell mediated cell killing" EXACT []
synonym: "immune cell mediated cytotoxicity" EXACT []
synonym: "leucocyte mediated cytotoxicity" EXACT []
is_a: GO:0001906 ! cell killing
is_a: GO:0002443 ! leukocyte mediated immunity
intersection_of: GO:0001906 ! cell killing
intersection_of: RO:0002608 CL:0000738 ! process has causal agent leukocyte
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002608 CL:0000738 ! process has causal agent leukocyte
[Term]
id: GO:0001910
name: regulation of leukocyte mediated cytotoxicity
def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149, PMID:11911826]
synonym: "regulation of immune cell mediated cell death" EXACT []
synonym: "regulation of immune cell mediated cell killing" EXACT []
synonym: "regulation of immune cell mediated cytotoxicity" EXACT []
synonym: "regulation of leucocyte mediated cytotoxicity" EXACT []
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
is_a: GO:0031341 ! regulation of cell killing
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0001909 ! regulates (processual) leukocyte mediated cytotoxicity
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002211 GO:0001909 ! regulates (processual) leukocyte mediated cytotoxicity
[Term]
id: GO:0001911
name: negative regulation of leukocyte mediated cytotoxicity
def: "Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149, PMID:11911826]
synonym: "down regulation of leukocyte mediated cytotoxicity" EXACT []
synonym: "down-regulation of leukocyte mediated cytotoxicity" EXACT []
synonym: "downregulation of leukocyte mediated cytotoxicity" EXACT []
synonym: "inhibition of leukocyte mediated cytotoxicity" NARROW []
synonym: "negative regulation of immune cell mediated cytotoxicity" EXACT []
synonym: "negative regulation of leucocyte mediated cytotoxicity" EXACT []
is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity
is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity
is_a: GO:0031342 ! negative regulation of cell killing
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0001909 ! negatively regulates leukocyte mediated cytotoxicity
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002212 GO:0001909 ! negatively regulates leukocyte mediated cytotoxicity
[Term]
id: GO:0001912
name: positive regulation of leukocyte mediated cytotoxicity
def: "Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149, PMID:11911826]
synonym: "activation of leukocyte mediated cytotoxicity" NARROW []
synonym: "positive regulation of immune cell mediated cytotoxicity" EXACT []
synonym: "positive regulation of leucocyte mediated cytotoxicity" EXACT []
synonym: "stimulation of leukocyte mediated cytotoxicity" NARROW []
synonym: "up regulation of leukocyte mediated cytotoxicity" EXACT []
synonym: "up-regulation of leukocyte mediated cytotoxicity" EXACT []
synonym: "upregulation of leukocyte mediated cytotoxicity" EXACT []
is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity
is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity
is_a: GO:0031343 ! positive regulation of cell killing
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0001909 ! positively regulates leukocyte mediated cytotoxicity
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002213 GO:0001909 ! positively regulates leukocyte mediated cytotoxicity
[Term]
id: GO:0001913
name: T cell mediated cytotoxicity
def: "The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, GOC:pr, ISBN:0781735149, PMID:11911826]
comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in the induction of apoptosis in the target cell. Note that both CD4 and CD8 positive T cells can mediate apoptosis of target cells, independently of their definition as 'helper' T cells or not.
synonym: "T cell mediated apoptosis" EXACT []
synonym: "T cell mediated cell death" EXACT []
synonym: "T cell mediated cell killing" EXACT []
synonym: "T cell mediated cytolysis" RELATED []
synonym: "T lymphocyte mediated cytotoxicity" EXACT []
synonym: "T-cell mediated apoptosis" EXACT []
synonym: "T-cell mediated cell death" EXACT []
synonym: "T-cell mediated cell killing" EXACT []
synonym: "T-cell mediated cytotoxicity" EXACT []
synonym: "T-lymphocyte mediated cytotoxicity" EXACT []
is_a: GO:0001909 ! leukocyte mediated cytotoxicity
is_a: GO:0002456 ! T cell mediated immunity
intersection_of: GO:0001906 ! cell killing
intersection_of: RO:0002608 CL:0000084 ! process has causal agent T cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002608 CL:0000084 ! process has causal agent T cell
[Term]
id: GO:0001914
name: regulation of T cell mediated cytotoxicity
def: "Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149]
synonym: "regulation of T cell mediated apoptosis" EXACT []
synonym: "regulation of T cell mediated cell death" EXACT []
synonym: "regulation of T cell mediated cell killing" EXACT []
synonym: "regulation of T cell mediated cytolysis" RELATED []
synonym: "regulation of T lymphocyte mediated cytotoxicity" EXACT []
synonym: "regulation of T-cell mediated apoptosis" EXACT []
synonym: "regulation of T-cell mediated cell death" EXACT []
synonym: "regulation of T-cell mediated cell killing" EXACT []
synonym: "regulation of T-cell mediated cytolysis" RELATED []
synonym: "regulation of T-cell mediated cytotoxicity" EXACT []
synonym: "regulation of T-lymphocyte mediated cytotoxicity" EXACT []
is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity
is_a: GO:0002709 ! regulation of T cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0001913 ! regulates (processual) T cell mediated cytotoxicity
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: RO:0002211 GO:0001913 ! regulates (processual) T cell mediated cytotoxicity
[Term]
id: GO:0001915
name: negative regulation of T cell mediated cytotoxicity
def: "Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149]
synonym: "down regulation of T cell mediated cytotoxicity" EXACT []
synonym: "down-regulation of T cell mediated cytotoxicity" EXACT []
synonym: "downregulation of T cell mediated cytotoxicity" EXACT []
synonym: "inhibition of T cell mediated cytotoxicity" NARROW []
synonym: "negative regulation of T cell mediated apoptosis" EXACT []
synonym: "negative regulation of T cell mediated cell death" EXACT []
synonym: "negative regulation of T cell mediated cell killing" EXACT []
synonym: "negative regulation of T cell mediated cytolysis" RELATED []
synonym: "negative regulation of T lymphocyte mediated cytotoxicity" EXACT []
synonym: "negative regulation of T-cell mediated apoptosis" EXACT []
synonym: "negative regulation of T-cell mediated cell death" EXACT []
synonym: "negative regulation of T-cell mediated cell killing" EXACT []
synonym: "negative regulation of T-cell mediated cytolysis" RELATED []
synonym: "negative regulation of T-cell mediated cytotoxicity" EXACT []
synonym: "negative regulation of T-lymphocyte mediated cytotoxicity" EXACT []
is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity
is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity
is_a: GO:0002710 ! negative regulation of T cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0001913 ! negatively regulates T cell mediated cytotoxicity
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: RO:0002212 GO:0001913 ! negatively regulates T cell mediated cytotoxicity
[Term]
id: GO:0001916
name: positive regulation of T cell mediated cytotoxicity
def: "Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149]
synonym: "activation of T cell mediated cytotoxicity" NARROW []
synonym: "positive regulation of T cell mediated apoptosis" EXACT []
synonym: "positive regulation of T cell mediated cell death" EXACT []
synonym: "positive regulation of T cell mediated cell killing" EXACT []
synonym: "positive regulation of T cell mediated cytolysis" RELATED []
synonym: "positive regulation of T lymphocyte mediated cytotoxicity" EXACT []
synonym: "positive regulation of T-cell mediated apoptosis" EXACT []
synonym: "positive regulation of T-cell mediated cell death" EXACT []
synonym: "positive regulation of T-cell mediated cell killing" EXACT []
synonym: "positive regulation of T-cell mediated cytolysis" RELATED []
synonym: "positive regulation of T-cell mediated cytotoxicity" EXACT []
synonym: "positive regulation of T-lymphocyte mediated cytotoxicity" EXACT []
synonym: "stimulation of T cell mediated cytotoxicity" NARROW []
synonym: "up regulation of T cell mediated cytotoxicity" EXACT []
synonym: "up-regulation of T cell mediated cytotoxicity" EXACT []
synonym: "upregulation of T cell mediated cytotoxicity" EXACT []
is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity
is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0001913 ! positively regulates T cell mediated cytotoxicity
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: RO:0002213 GO:0001913 ! positively regulates T cell mediated cytotoxicity
[Term]
id: GO:0001917
name: photoreceptor inner segment
def: "The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs." [GOC:add, PMID:12019563]
subset: goslim_pir
is_a: GO:0110165 ! cellular anatomical entity
relationship: in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of CL:0000210 ! photoreceptor cell
[Term]
id: GO:0001922
name: B-1 B cell homeostasis
def: "The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149]
comment: Note that this term represents the return of B-1 B cell levels to stable numbers following an immune response, as well as the proliferation and elimination of B-1 B cells in a organism required to maintain stable numbers in the absence of an outside stimulus.
synonym: "B-1 B lymphocyte homeostasis" EXACT []
synonym: "B-1 B-cell homeostasis" EXACT []
synonym: "B-1 B-lymphocyte homeostasis" EXACT []
is_a: GO:0001782 ! B cell homeostasis
intersection_of: GO:0048872 ! homeostasis of number of cells
intersection_of: RO:0012003 CL:0000819 ! acts on population of B-1 B cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0012003 CL:0000819 ! acts on population of B-1 B cell
[Term]
id: GO:0001923
name: B-1 B cell differentiation
def: "The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149]
synonym: "B-1 B cell development" RELATED [GOC:add]
synonym: "B-1 B lymphocyte differentiation" EXACT []
synonym: "B-1 B-cell differentiation" EXACT []
synonym: "B-1 B-lymphocyte differentiation" EXACT []
is_a: GO:0002335 ! mature B cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000819 ! results in acquisition of features of B-1 B cell
relationship: in_taxon NCBITaxon:40674 ! Mammalia
relationship: RO:0002315 CL:0000819 ! results in acquisition of features of B-1 B cell
[Term]
id: GO:0001924
name: regulation of B-1 B cell differentiation
def: "Any process that modulates the frequency, rate, or extent of B-1 B cell differentiation. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of B-1 B cell development" RELATED [GOC:add]
synonym: "regulation of B-1 B lymphocyte differentiation" EXACT []
synonym: "regulation of B-1 B-cell differentiation" EXACT []
synonym: "regulation of B-1 B-lymphocyte differentiation" EXACT []
is_a: GO:0045577 ! regulation of B cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0001923 ! regulates (processual) B-1 B cell differentiation
relationship: in_taxon NCBITaxon:40674 ! Mammalia
relationship: RO:0002211 GO:0001923 ! regulates (processual) B-1 B cell differentiation
[Term]
id: GO:0001925
name: negative regulation of B-1 B cell differentiation
def: "Any process that stops, prevents, or reduces the rate of B-1 B cell differentiation." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of B-1 B cell differentiation" EXACT []
synonym: "down-regulation of B-1 B cell differentiation" EXACT []
synonym: "downregulation of B-1 B cell differentiation" EXACT []
synonym: "inhibition of B-1 B cell differentiation" NARROW []
synonym: "negative regulation of B-1 B cell development" RELATED [GOC:add]
synonym: "negative regulation of B-1 B lymphocyte differentiation" EXACT []
synonym: "negative regulation of B-1 B-cell differentiation" EXACT []
synonym: "negative regulation of B-1 B-lymphocyte differentiation" EXACT []
is_a: GO:0001924 ! regulation of B-1 B cell differentiation
is_a: GO:0045578 ! negative regulation of B cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0001923 ! negatively regulates B-1 B cell differentiation
relationship: in_taxon NCBITaxon:40674 ! Mammalia
relationship: RO:0002212 GO:0001923 ! negatively regulates B-1 B cell differentiation
[Term]
id: GO:0001926
name: positive regulation of B-1 B cell differentiation
def: "Any process that activates or increases the frequency, rate or extent of B-1 B cell differentiation." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of B-1 B cell differentiation" NARROW []
synonym: "positive regulation of B-1 B cell development" RELATED [GOC:add]
synonym: "positive regulation of B-1 B lymphocyte differentiation" EXACT []
synonym: "positive regulation of B-1 B-cell differentiation" EXACT []
synonym: "positive regulation of B-1 B-lymphocyte differentiation" EXACT []
synonym: "stimulation of B-1 B cell differentiation" NARROW []
synonym: "up regulation of B-1 B cell differentiation" EXACT []
synonym: "up-regulation of B-1 B cell differentiation" EXACT []
synonym: "upregulation of B-1 B cell differentiation" EXACT []
is_a: GO:0001924 ! regulation of B-1 B cell differentiation
is_a: GO:0045579 ! positive regulation of B cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0001923 ! positively regulates B-1 B cell differentiation
relationship: in_taxon NCBITaxon:40674 ! Mammalia
relationship: RO:0002213 GO:0001923 ! positively regulates B-1 B cell differentiation
[Term]
id: GO:0001932
name: regulation of protein phosphorylation
def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd]
subset: gocheck_obsoletion_candidate
synonym: "regulation of protein amino acid phosphorylation" EXACT [GOC:bf]
is_a: GO:0031399 ! regulation of protein modification process
is_a: GO:0042325 ! regulation of phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006468 ! regulates (processual) protein phosphorylation
relationship: RO:0002211 GO:0006468 ! regulates (processual) protein phosphorylation
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28278" xsd:anyURI
[Term]
id: GO:0001933
name: negative regulation of protein phosphorylation
def: "Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein." [GOC:hjd]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of protein amino acid phosphorylation" EXACT []
synonym: "down-regulation of protein amino acid phosphorylation" EXACT []
synonym: "downregulation of protein amino acid phosphorylation" EXACT []
synonym: "inhibition of protein amino acid phosphorylation" NARROW []
synonym: "negative regulation of protein amino acid phosphorylation" EXACT [GOC:bf]
is_a: GO:0001932 ! regulation of protein phosphorylation
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:0042326 ! negative regulation of phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006468 ! negatively regulates protein phosphorylation
relationship: RO:0002212 GO:0006468 ! negatively regulates protein phosphorylation
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28278" xsd:anyURI
[Term]
id: GO:0001934
name: positive regulation of protein phosphorylation
def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]
subset: gocheck_obsoletion_candidate
synonym: "activation of protein amino acid phosphorylation" NARROW []
synonym: "positive regulation of protein amino acid phosphorylation" EXACT [GOC:bf]
synonym: "stimulation of protein amino acid phosphorylation" NARROW []
synonym: "up regulation of protein amino acid phosphorylation" EXACT []
synonym: "up-regulation of protein amino acid phosphorylation" EXACT []
synonym: "upregulation of protein amino acid phosphorylation" EXACT []
is_a: GO:0001932 ! regulation of protein phosphorylation
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:0042327 ! positive regulation of phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006468 ! positively regulates protein phosphorylation
relationship: RO:0002213 GO:0006468 ! positively regulates protein phosphorylation
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27189" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28278" xsd:anyURI
[Term]
id: GO:0001935
name: endothelial cell proliferation
def: "The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [GOC:add, ISBN:0781735149]
is_a: GO:0050673 ! epithelial cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000115 ! acts on population of endothelial cell
relationship: never_in_taxon NCBITaxon:4751 ! Fungi
relationship: RO:0012003 CL:0000115 ! acts on population of endothelial cell
[Term]
id: GO:0001936
name: regulation of endothelial cell proliferation
def: "Any process that modulates the frequency, rate, or extent of endothelial cell proliferation." [GOC:add]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0001935 ! regulates (processual) endothelial cell proliferation
relationship: never_in_taxon NCBITaxon:4751 ! Fungi
relationship: RO:0002211 GO:0001935 ! regulates (processual) endothelial cell proliferation
[Term]
id: GO:0001937
name: negative regulation of endothelial cell proliferation
def: "Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation." [GOC:add]
synonym: "down regulation of endothelial cell proliferation" EXACT []
synonym: "down-regulation of endothelial cell proliferation" EXACT []
synonym: "downregulation of endothelial cell proliferation" EXACT []
synonym: "inhibition of endothelial cell proliferation" NARROW []
is_a: GO:0001936 ! regulation of endothelial cell proliferation
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0001935 ! negatively regulates endothelial cell proliferation
relationship: never_in_taxon NCBITaxon:4751 ! Fungi
relationship: RO:0002212 GO:0001935 ! negatively regulates endothelial cell proliferation
[Term]
id: GO:0001938
name: positive regulation of endothelial cell proliferation
def: "Any process that activates or increases the rate or extent of endothelial cell proliferation." [GOC:add]
synonym: "activation of endothelial cell proliferation" NARROW []
synonym: "stimulation of endothelial cell proliferation" NARROW []
synonym: "up regulation of endothelial cell proliferation" EXACT []
synonym: "up-regulation of endothelial cell proliferation" EXACT []
synonym: "upregulation of endothelial cell proliferation" EXACT []
is_a: GO:0001936 ! regulation of endothelial cell proliferation
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0001935 ! positively regulates endothelial cell proliferation
relationship: never_in_taxon NCBITaxon:4751 ! Fungi
relationship: RO:0002213 GO:0001935 ! positively regulates endothelial cell proliferation
[Term]
id: GO:0001940
name: male pronucleus
def: "The pronucleus originating from the spermatozoa that was involved in fertilization." [GOC:hjd, ISBN:0198506732]
is_a: GO:0045120 ! pronucleus
relationship: in_taxon NCBITaxon:33208 ! Metazoa
[Term]
id: GO:0001941
name: postsynaptic membrane organization
def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft)." [GOC:dph, GOC:pr]
synonym: "post-synaptic membrane organization" EXACT []
synonym: "postsynaptic membrane organisation" EXACT []
is_a: GO:0061024 ! membrane organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0045211 ! results in organization of postsynaptic membrane
relationship: part_of GO:0099173 ! postsynapse organization
relationship: RO:0002592 GO:0045211 ! results in organization of postsynaptic membrane
[Term]
id: GO:0001942
name: hair follicle development
alt_id: GO:0001943
def: "The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open." [GOC:dph, UBERON:0002073]
is_a: GO:0022405 ! hair cycle process
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002073 ! results in development of hair follicle
relationship: in_taxon NCBITaxon:40674 ! Mammalia
relationship: part_of GO:0098773 ! skin epidermis development
relationship: RO:0002296 UBERON:0002073 ! results in development of hair follicle
[Term]
id: GO:0001944
name: vasculature development
def: "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism." [GOC:dph, UBERON:0002409]
synonym: "vascular system development" RELATED []
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002049 ! results in development of vasculature
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0072359 ! circulatory system development
relationship: RO:0002296 UBERON:0002049 ! results in development of vasculature
[Term]
id: GO:0001945
name: lymph vessel development
def: "The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure." [GOC:dph, UBERON:0001473]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001473 ! results in development of lymphatic vessel
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0001944 ! vasculature development
relationship: RO:0002296 UBERON:0001473 ! results in development of lymphatic vessel
[Term]
id: GO:0001946
name: lymphangiogenesis
def: "Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels." [GOC:dph, PMID:11596157]
synonym: "lymph vessel formation" EXACT systematic_synonym []
xref: Wikipedia:Lymphangiogenesis
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0001473 ! results in formation of anatomical entity lymphatic vessel
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0036303 ! lymph vessel morphogenesis
relationship: RO:0002297 UBERON:0001473 ! results in formation of anatomical entity lymphatic vessel
[Term]
id: GO:0001949
name: sebaceous gland cell differentiation
def: "The process in which a relatively unspecialized epidermal cell acquires the specialized features of a sebaceous gland cell." [GOC:mgi_curators, PMID:15737203]
synonym: "sebocytes differentiation" NARROW [GOC:mgi_curators]
is_a: GO:0009913 ! epidermal cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:2000021 ! results in acquisition of features of sebaceous gland cell
relationship: in_taxon NCBITaxon:40674 ! Mammalia
relationship: part_of GO:0048733 ! sebaceous gland development
relationship: RO:0002315 CL:2000021 ! results in acquisition of features of sebaceous gland cell
[Term]
id: GO:0001955
name: blood vessel maturation
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state." [GOC:dph]
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 UBERON:0001981 ! results in maturation of blood vessel
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0001568 ! blood vessel development
relationship: RO:0002299 UBERON:0001981 ! results in maturation of blood vessel
[Term]
id: GO:0001956
name: positive regulation of neurotransmitter secretion
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:hjd]
synonym: "activation of neurotransmitter secretion" NARROW []
synonym: "stimulation of neurotransmitter secretion" NARROW []
synonym: "up regulation of neurotransmitter secretion" EXACT []
synonym: "up-regulation of neurotransmitter secretion" EXACT []
synonym: "upregulation of neurotransmitter secretion" EXACT []
is_a: GO:0046928 ! regulation of neurotransmitter secretion
is_a: GO:0050806 ! positive regulation of synaptic transmission
is_a: GO:0051590 ! positive regulation of neurotransmitter transport
is_a: GO:1903532 ! positive regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007269 ! positively regulates neurotransmitter secretion
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: RO:0002213 GO:0007269 ! positively regulates neurotransmitter secretion
[Term]
id: GO:0001957
name: intramembranous ossification
def: "Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells." [ISBN:0878932437]
comment: An instance of intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division.
synonym: "dermal ossification" NARROW [GO_REF:0000034]
synonym: "intramembranous bone ossification" RELATED [GOC:cjm]
xref: Wikipedia:Intramembranous_ossification
is_a: GO:0036072 ! direct ossification
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
[Term]
id: GO:0001958
name: endochondral ossification
def: "Replacement ossification wherein bone tissue replaces cartilage." [GO_REF:0000034, ISBN:0878932437]
xref: Wikipedia:Endochondral_ossification
is_a: GO:0036075 ! replacement ossification
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0060350 ! endochondral bone morphogenesis
[Term]
id: GO:0001959
name: regulation of cytokine-mediated signaling pathway
def: "Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd]
synonym: "regulation of cytokine and chemokine mediated signaling pathway" EXACT []
synonym: "regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of cytokine mediated signalling pathway" EXACT []
xref: Reactome:R-HSA-8939247 "RUNX1 regulates transcription of genes involved in interleukin signaling"
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0060759 ! regulation of response to cytokine stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0019221 ! regulates (processual) cytokine-mediated signaling pathway
relationship: RO:0002211 GO:0019221 ! regulates (processual) cytokine-mediated signaling pathway
[Term]
id: GO:0001960
name: negative regulation of cytokine-mediated signaling pathway
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd]
synonym: "down regulation of cytokine mediated signaling pathway" EXACT []
synonym: "down-regulation of cytokine mediated signaling pathway" EXACT []
synonym: "downregulation of cytokine mediated signaling pathway" EXACT []
synonym: "inhibition of cytokine mediated signaling pathway" NARROW []
synonym: "negative regulation of cytokine and chemokine mediated signaling pathway" EXACT []
synonym: "negative regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of cytokine mediated signalling pathway" EXACT []
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0060761 ! negative regulation of response to cytokine stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0019221 ! negatively regulates cytokine-mediated signaling pathway
relationship: RO:0002212 GO:0019221 ! negatively regulates cytokine-mediated signaling pathway
[Term]
id: GO:0001961
name: positive regulation of cytokine-mediated signaling pathway
def: "Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway." [GOC:hjd]
synonym: "activation of cytokine mediated signaling pathway" NARROW []
synonym: "positive regulation of cytokine and chemokine mediated signaling pathway" EXACT []
synonym: "positive regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of cytokine mediated signalling pathway" EXACT []
synonym: "stimulation of cytokine mediated signaling pathway" NARROW []
synonym: "up regulation of cytokine mediated signaling pathway" EXACT []
synonym: "up-regulation of cytokine mediated signaling pathway" EXACT []
synonym: "upregulation of cytokine mediated signaling pathway" EXACT []
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0060760 ! positive regulation of response to cytokine stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0019221 ! positively regulates cytokine-mediated signaling pathway
relationship: RO:0002213 GO:0019221 ! positively regulates cytokine-mediated signaling pathway
[Term]
id: GO:0001963
name: synaptic transmission, dopaminergic
def: "The vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos, GOC:dph]
synonym: "dopaminergic synaptic transmission" EXACT []
is_a: GO:0007268 ! chemical synaptic transmission
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: RO:0000057 CHEBI:59905 ! has participant dopaminium(1+)
relationship: RO:0000057 CL:0000700 ! has participant dopaminergic neuron
[Term]
id: GO:0001973
name: G protein-coupled adenosine receptor signaling pathway
def: "The series of molecular signals generated as a consequence of a receptor binding to extracellular adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity." [GOC:dph]
synonym: "adenosine receptor signaling pathway" RELATED []
synonym: "adenosine receptor signaling pathway, G-protein coupled" EXACT [PMID:9755289]
synonym: "adenosine receptor signalling pathway" EXACT [GOC:mah]
synonym: "P1 receptor signaling pathway" EXACT [PMID:9755289]
is_a: GO:0035588 ! G protein-coupled purinergic receptor signaling pathway
[Term]
id: GO:0001976
name: nervous system process involved in regulation of systemic arterial blood pressure
def: "The regulation of blood pressure mediated by detection of stimuli and a neurological response." [GOC:mtg_cardio, ISBN:0721643949]
synonym: "blood pressure regulation by neurological process" EXACT []
synonym: "fast control of arterial pressure" RELATED []
synonym: "neurological process involved in regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
synonym: "neurological system process involved in regulation of systemic arterial blood pressure" EXACT []
is_a: GO:0050877 ! nervous system process
intersection_of: GO:0050877 ! nervous system process
intersection_of: part_of GO:0003073 ! regulation of systemic arterial blood pressure
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure
[Term]
id: GO:0001977
name: renal system process involved in regulation of blood volume
def: "A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system." [GOC:dph, GOC:tb, ISBN:0721643949]
subset: gocheck_obsoletion_candidate
synonym: "renal blood volume control of blood pressure" RELATED []
synonym: "renal regulation of blood volume" RELATED [GOC:dph, GOC:tb]
is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
relationship: part_of GO:0050878 ! regulation of body fluid levels
[Term]
id: GO:0001978
name: regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback
def: "The process that modulates blood pressure by sensing the amount of stretch occurring in large arteries and responding to the input via central nervous system control." [GOC:dph, GOC:tb, ISBN:0721643949]
synonym: "baroreceptor feedback control of blood pressure" RELATED []
synonym: "baroreceptor pressure buffer system" RELATED [ISBN:068340007X]
synonym: "carotid sinus baroreceptor feedback regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback
[Term]
id: GO:0001979
name: regulation of systemic arterial blood pressure by chemoreceptor signaling
def: "The process that modulates blood pressure by the action of chemoreceptors found in the carotid and aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:tb, ISBN:0721643949]
synonym: "chemoreceptor control of blood pressure" RELATED []
synonym: "chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of systemic arterial blood pressure by chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure
relationship: in_taxon NCBITaxon:33208 ! Metazoa
[Term]
id: GO:0001990
name: regulation of systemic arterial blood pressure by hormone
def: "The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, ISBN:0721643949]
synonym: "blood pressure regulation by hormone" EXACT []
synonym: "hormonal control of blood pressure" RELATED []
synonym: "hormonal regulation of blood pressure" EXACT []
is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal
is_a: GO:0050886 ! endocrine process
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
[Term]
id: GO:0001991
name: regulation of systemic arterial blood pressure by circulatory renin-angiotensin
def: "The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen." [ISBN:0721643949]
synonym: "circulatory renin-angiotensin blood pressure regulation" EXACT []
synonym: "circulatory renin-angiotensin control of blood pressure" RELATED []
synonym: "circulatory renin-angiotensin regulation of blood pressure" EXACT []
synonym: "control of blood pressure by circulatory renin-angiotensin" RELATED []
synonym: "renin-angiotensin blood pressure control" RELATED []
is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
[Term]
id: GO:0001992
name: regulation of systemic arterial blood pressure by vasopressin
def: "The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport." [GOC:mtg_cardio, ISBN:0721643949]
synonym: "blood pressure regulation by vasopressin" EXACT []
synonym: "vasopressin control of blood pressure" RELATED []
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
[Term]
id: GO:0001999
name: renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure
def: "The physiological response of the kidneys to a decrease in blood flow." [GOC:dph]
synonym: "renal response to blood flow during renin-angiotensin control of blood pressure" RELATED []
is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
relationship: part_of GO:0001991 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin
[Term]
id: GO:0002001
name: renin secretion into blood stream
def: "The regulated release of renin into the blood stream by juxtoglomerular cells." [ISBN:0721643949]
synonym: "renin release into blood stream" EXACT []
is_a: GO:0009306 ! protein secretion
is_a: GO:0023061 ! signal release
intersection_of: GO:0046903 ! secretion
intersection_of: RO:0004009 PR:000013883 ! has primary input renin
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
relationship: part_of GO:0001999 ! renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure
relationship: RO:0004009 PR:000013883 ! has primary input renin
[Term]
id: GO:0002007
name: detection of hypoxic conditions in blood by chemoreceptor signaling
def: "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:dph]
synonym: "detection of hypoxic conditions in blood by chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0009593 ! detection of chemical stimulus
relationship: has_part GO:0003022 ! detection of pH by chemoreceptor signaling
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling
relationship: part_of GO:0070887 ! cellular response to chemical stimulus
[Term]
id: GO:0002009
name: morphogenesis of an epithelium
def: "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732]
synonym: "epithelium morphogenesis" EXACT []
is_a: GO:0048729 ! tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0000483 ! results in morphogenesis of epithelium
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: part_of GO:0060429 ! epithelium development
relationship: RO:0002298 UBERON:0000483 ! results in morphogenesis of epithelium
[Term]
id: GO:0002011
name: morphogenesis of an epithelial sheet
def: "The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells." [GOC:jl]
is_a: GO:0002009 ! morphogenesis of an epithelium
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0010136 ! results in morphogenesis of epithelial sheet
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: RO:0002298 UBERON:0010136 ! results in morphogenesis of epithelial sheet
[Term]
id: GO:0002016
name: regulation of blood volume by renin-angiotensin
def: "The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949]
synonym: "renin-angiotensin control of body fluid levels" RELATED []
synonym: "renin-angiotensin regulation of blood volume" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
[Term]
id: GO:0002018
name: renin-angiotensin regulation of aldosterone production
def: "The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone." [ISBN:0721643949]
synonym: "renin-angiotensin control of aldosterone production" RELATED []
is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure
is_a: GO:2000858 ! regulation of aldosterone secretion
intersection_of: GO:0003014 ! renal system process
intersection_of: part_of GO:0002016 ! regulation of blood volume by renin-angiotensin
intersection_of: RO:0002211 GO:0035932 ! regulates (processual) aldosterone secretion
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
relationship: part_of GO:0002016 ! regulation of blood volume by renin-angiotensin
relationship: RO:0002211 GO:0035932 ! regulates (processual) aldosterone secretion
[Term]
id: GO:0002027
name: regulation of heart rate
def: "Any process that modulates the frequency or rate of heart contraction." [GOC:dph, GOC:tb, PMID:10358008]
synonym: "cardiac chronotropy" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of heart contraction rate" EXACT []
synonym: "regulation of rate of heart contraction" EXACT []
is_a: GO:0008016 ! regulation of heart contraction
is_a: GO:0065008 ! regulation of biological quality
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
[Term]
id: GO:0002028
name: regulation of sodium ion transport
def: "Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph]
synonym: "regulation of Na+ transport" EXACT []
synonym: "regulation of sodium transport" EXACT []
is_a: GO:0010959 ! regulation of metal ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006814 ! regulates (processual) sodium ion transport
relationship: RO:0002211 GO:0006814 ! regulates (processual) sodium ion transport
[Term]
id: GO:0002036
name: regulation of L-glutamate import across plasma membrane
alt_id: GO:1900920
def: "Any process that modulates the frequency, rate or extent of L-glutamate import into a cell." [GOC:TermGenie]
synonym: "regulation of L-glutamate import" BROAD []
synonym: "regulation of L-glutamate transport" BROAD []
synonym: "regulation of L-glutamate uptake" EXACT [GOC:TermGenie]
is_a: GO:0010958 ! regulation of amino acid import across plasma membrane
is_a: GO:0032890 ! regulation of organic acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0098712 ! regulates (processual) L-glutamate import across plasma membrane
relationship: RO:0002211 GO:0098712 ! regulates (processual) L-glutamate import across plasma membrane
created_by: al
creation_date: 2012-06-13T07:34:08Z
[Term]
id: GO:0002037
name: negative regulation of L-glutamate import across plasma membrane
alt_id: GO:1900921
def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamate import into a cell." [GOC:TermGenie]
synonym: "down regulation of L-glutamate import" EXACT [GOC:TermGenie]
synonym: "down regulation of L-glutamate transport" BROAD []
synonym: "down regulation of L-glutamate uptake" RELATED [GOC:TermGenie]
synonym: "down-regulation of L-glutamate import" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-glutamate transport" BROAD []
synonym: "down-regulation of L-glutamate uptake" RELATED [GOC:TermGenie]
synonym: "downregulation of L-glutamate import" EXACT [GOC:TermGenie]
synonym: "downregulation of L-glutamate transport" BROAD []
synonym: "downregulation of L-glutamate uptake" RELATED [GOC:TermGenie]
synonym: "inhibition of L-glutamate import" NARROW [GOC:TermGenie]
synonym: "inhibition of L-glutamate transport" NARROW []
synonym: "inhibition of L-glutamate uptake" NARROW [GOC:TermGenie]
synonym: "negative regulation of L-glutamate import" BROAD []
synonym: "negative regulation of L-glutamate transport" BROAD []
synonym: "negative regulation of L-glutamate uptake" RELATED [GOC:TermGenie]
synonym: "regulation of L-glutamate import" BROAD []
is_a: GO:0002036 ! regulation of L-glutamate import across plasma membrane
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:0051956 ! negative regulation of amino acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0098712 ! negatively regulates L-glutamate import across plasma membrane
relationship: RO:0002212 GO:0098712 ! negatively regulates L-glutamate import across plasma membrane
created_by: al
creation_date: 2012-06-13T07:34:30Z
[Term]
id: GO:0002038
name: positive regulation of L-glutamate import across plasma membrane
alt_id: GO:1900922
def: "Any process that activates or increases the frequency, rate or extent of L-glutamate import into a cell." [GOC:TermGenie]
synonym: "activation of L-glutamate import" NARROW [GOC:TermGenie]
synonym: "activation of L-glutamate transport" NARROW []
synonym: "activation of L-glutamate uptake" NARROW [GOC:TermGenie]
synonym: "positive regulation of L-glutamate import" BROAD []
synonym: "positive regulation of L-glutamate transport" BROAD []
synonym: "positive regulation of L-glutamate uptake" RELATED [GOC:TermGenie]
synonym: "stimulation of L-glutamate transport" NARROW []
synonym: "up regulation of L-glutamate import" EXACT [GOC:TermGenie]
synonym: "up regulation of L-glutamate transport" BROAD []
synonym: "up regulation of L-glutamate uptake" RELATED [GOC:TermGenie]
synonym: "up-regulation of L-glutamate import" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-glutamate transport" EXACT []
synonym: "up-regulation of L-glutamate uptake" RELATED [GOC:TermGenie]
synonym: "upregulation of L-glutamate import" EXACT [GOC:TermGenie]
synonym: "upregulation of L-glutamate transport" BROAD []
synonym: "upregulation of L-glutamate uptake" RELATED [GOC:TermGenie]
is_a: GO:0002036 ! regulation of L-glutamate import across plasma membrane
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:0051957 ! positive regulation of amino acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0098712 ! positively regulates L-glutamate import across plasma membrane
relationship: RO:0002213 GO:0098712 ! positively regulates L-glutamate import across plasma membrane
created_by: al
creation_date: 2012-06-13T07:34:38Z
[Term]
id: GO:0002052
name: positive regulation of neuroblast proliferation
def: "Any process that activates or increases the rate of neuroblast proliferation." [GOC:dph]
synonym: "activation of neuroblast proliferation" NARROW []
synonym: "stimulation of neuroblast proliferation" NARROW []
synonym: "up regulation of neuroblast proliferation" EXACT []
synonym: "up-regulation of neuroblast proliferation" EXACT []
synonym: "upregulation of neuroblast proliferation" EXACT []
is_a: GO:0050769 ! positive regulation of neurogenesis
is_a: GO:1902692 ! regulation of neuroblast proliferation
is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007405 ! positively regulates neuroblast proliferation
relationship: in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: RO:0002213 GO:0007405 ! positively regulates neuroblast proliferation
[Term]
id: GO:0002053
name: positive regulation of mesenchymal cell proliferation
def: "The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells." [GOC:dph]
synonym: "activation of mesenchymal cell proliferation" NARROW []
synonym: "stimulation of mesenchymal cell proliferation" NARROW []
synonym: "up regulation of mesenchymal cell proliferation" EXACT []
synonym: "up-regulation of mesenchymal cell proliferation" EXACT []
synonym: "upregulation of mesenchymal cell proliferation" EXACT []
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0010464 ! regulation of mesenchymal cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0010463 ! positively regulates mesenchymal cell proliferation
relationship: never_in_taxon NCBITaxon:4751 ! Fungi
relationship: RO:0002213 GO:0010463 ! positively regulates mesenchymal cell proliferation
[Term]
id: GO:0002054
name: nucleobase binding
def: "Binding to a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases." [GOC:hjd]
subset: goslim_pir
is_a: GO:1901363 ! heterocyclic compound binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:18282 ! has primary input nucleobase
relationship: RO:0004009 CHEBI:18282 ! has primary input nucleobase
[Term]
id: GO:0002055
name: adenine binding
def: "Binding to adenine, a purine base." [GOC:hjd]
synonym: "6-aminopurine binding" EXACT []
is_a: GO:0002060 ! purine nucleobase binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:16708 ! has primary input adenine
relationship: RO:0004009 CHEBI:16708 ! has primary input adenine
[Term]
id: GO:0002060
name: purine nucleobase binding
def: "Binding to a purine nucleobase, an organic nitrogenous base with a purine skeleton." [GOC:hjd]
synonym: "purine base binding" EXACT [GOC:go_curators]
synonym: "purine binding" RELATED []
is_a: GO:0002054 ! nucleobase binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:26386 ! has primary input purine nucleobase
relationship: RO:0004009 CHEBI:26386 ! has primary input purine nucleobase
[Term]
id: GO:0002062
name: chondrocyte differentiation
def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:dph]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000138 ! results in acquisition of features of chondrocyte
relationship: in_taxon NCBITaxon:33213 ! Bilateria
relationship: part_of GO:0051216 ! cartilage development
relationship: RO:0002315 CL:0000138 ! results in acquisition of features of chondrocyte
[Term]
id: GO:0002063
name: chondrocyte development
def: "The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:dph]
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000138 ! results in development of chondrocyte
relationship: in_taxon NCBITaxon:33213 ! Bilateria
relationship: part_of GO:0002062 ! chondrocyte differentiation
relationship: RO:0002296 CL:0000138 ! results in development of chondrocyte
[Term]
id: GO:0002064
name: epithelial cell development
def: "The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph]
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000066 ! results in development of epithelial cell
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: part_of GO:0030855 ! epithelial cell differentiation
relationship: RO:0002296 CL:0000066 ! results in development of epithelial cell
[Term]
id: GO:0002065
name: columnar/cuboidal epithelial cell differentiation
def: "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph]
is_a: GO:0030855 ! epithelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000075 ! results in acquisition of features of columnar/cuboidal epithelial cell
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: RO:0002315 CL:0000075 ! results in acquisition of features of columnar/cuboidal epithelial cell
[Term]
id: GO:0002066
name: columnar/cuboidal epithelial cell development
def: "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph]
is_a: GO:0002064 ! epithelial cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000075 ! results in development of columnar/cuboidal epithelial cell
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: part_of GO:0002065 ! columnar/cuboidal epithelial cell differentiation
relationship: RO:0002296 CL:0000075 ! results in development of columnar/cuboidal epithelial cell
[Term]
id: GO:0002067
name: glandular epithelial cell differentiation
def: "The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph]
is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000150 ! results in acquisition of features of glandular secretory epithelial cell
relationship: in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: RO:0002315 CL:0000150 ! results in acquisition of features of glandular secretory epithelial cell
[Term]
id: GO:0002068
name: glandular epithelial cell development
def: "The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph]
is_a: GO:0002066 ! columnar/cuboidal epithelial cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000150 ! results in development of glandular secretory epithelial cell
relationship: in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of GO:0002067 ! glandular epithelial cell differentiation
relationship: RO:0002296 CL:0000150 ! results in development of glandular secretory epithelial cell
[Term]
id: GO:0002069
name: columnar/cuboidal epithelial cell maturation
def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph]
is_a: GO:0002070 ! epithelial cell maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 CL:0000075 ! results in maturation of columnar/cuboidal epithelial cell
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: part_of GO:0002066 ! columnar/cuboidal epithelial cell development
relationship: RO:0002299 CL:0000075 ! results in maturation of columnar/cuboidal epithelial cell
[Term]
id: GO:0002070
name: epithelial cell maturation
def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph]
is_a: GO:0048469 ! cell maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 CL:0000066 ! results in maturation of epithelial cell
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: part_of GO:0002064 ! epithelial cell development
relationship: RO:0002299 CL:0000066 ! results in maturation of epithelial cell
[Term]
id: GO:0002071
name: glandular epithelial cell maturation
def: "The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph]
is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 CL:0000150 ! results in maturation of glandular secretory epithelial cell
relationship: in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of GO:0002068 ! glandular epithelial cell development
relationship: RO:0002299 CL:0000150 ! results in maturation of glandular secretory epithelial cell
[Term]
id: GO:0002072
name: optic cup morphogenesis involved in camera-type eye development
def: "The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb, ISBN:0878932437]
synonym: "optic cup morphogenesis involved in camera-style eye development" EXACT []
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0003072 ! results in morphogenesis of optic cup
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0060900 ! embryonic camera-type eye formation
relationship: RO:0002298 UBERON:0003072 ! results in morphogenesis of optic cup
[Term]
id: GO:0002074
name: extraocular skeletal muscle development
def: "The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_muscle, GOC:mtg_sensu, MA:0001271, PMID:16638982]
is_a: GO:0007519 ! skeletal muscle tissue development
is_a: GO:0060538 ! skeletal muscle organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001601 ! results in development of extra-ocular muscle
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0043010 ! camera-type eye development
relationship: RO:0002296 UBERON:0001601 ! results in development of extra-ocular muscle
[Term]
id: GO:0002075
name: somitomeric trunk muscle development
def: "The process whose specific outcome is the progression of the somitomeric trunk muscle over time, from its formation to the mature structure. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus." [GOC:dph, PMID:16638982]
is_a: GO:0060538 ! skeletal muscle organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0004138 ! results in development of somitomeric trunk muscle
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002296 UBERON:0004138 ! results in development of somitomeric trunk muscle
[Term]
id: GO:0002076
name: osteoblast development
def: "The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone." [GOC:dph]
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000062 ! results in development of osteoblast
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0001649 ! osteoblast differentiation
relationship: RO:0002296 CL:0000062 ! results in development of osteoblast
[Term]
id: GO:0002080
name: acrosomal membrane
def: "The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization." [GOC:dph]
is_a: GO:0030667 ! secretory granule membrane
intersection_of: GO:0016020 ! membrane
intersection_of: bounding_layer_of GO:0001669 ! acrosomal vesicle
relationship: bounding_layer_of GO:0001669 ! acrosomal vesicle
relationship: in_taxon NCBITaxon:2759 ! Eukaryota
relationship: never_in_taxon NCBITaxon:3176
relationship: never_in_taxon NCBITaxon:3378
relationship: never_in_taxon NCBITaxon:3398
relationship: never_in_taxon NCBITaxon:4751 ! Fungi
relationship: never_in_taxon NCBITaxon:5782
relationship: part_of GO:0001669 ! acrosomal vesicle
[Term]
id: GO:0002085
name: inhibition of neuroepithelial cell differentiation
def: "Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, PMID:16678814]
synonym: "negative regulation of neural plate formation" NARROW [GOC:dph, GOC:tb]
synonym: "repression of premature neural plate formation" NARROW [GOC:dph, GOC:tb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0048505 ! regulation of timing of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0060563 ! negatively regulates neuroepithelial cell differentiation
relationship: in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: RO:0002212 GO:0060563 ! negatively regulates neuroepithelial cell differentiation
[Term]
id: GO:0002087
name: regulation of respiratory gaseous exchange by nervous system process
def: "A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates." [GOC:dph, GOC:tb, PMID:12458206]
synonym: "neurological control of breathing" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of respiratory gaseous exchange by neurological system process" EXACT []
is_a: GO:0044065 ! regulation of respiratory system process
is_a: GO:0050877 ! nervous system process
intersection_of: GO:0050877 ! nervous system process
intersection_of: RO:0002211 GO:0007585 ! regulates (processual) respiratory gaseous exchange by respiratory system
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: RO:0002211 GO:0007585 ! regulates (processual) respiratory gaseous exchange by respiratory system
[Term]
id: GO:0002088
name: lens development in camera-type eye
def: "The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, ISBN:0582064333]
synonym: "lens development" EXACT []
synonym: "lens development in camera-style eye" EXACT []
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000965 ! results in development of lens of camera-type eye
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0043010 ! camera-type eye development
relationship: RO:0002296 UBERON:0000965 ! results in development of lens of camera-type eye
[Term]
id: GO:0002089
name: lens morphogenesis in camera-type eye
def: "The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu]
synonym: "lens morphogenesis" EXACT []
synonym: "lens morphogenesis in camera-style eye" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0000965 ! results in morphogenesis of lens of camera-type eye
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0002088 ! lens development in camera-type eye
relationship: part_of GO:0048593 ! camera-type eye morphogenesis
relationship: RO:0002298 UBERON:0000965 ! results in morphogenesis of lens of camera-type eye
[Term]
id: GO:0002093
name: auditory receptor cell morphogenesis
def: "Any process that alters the size or shape of an auditory receptor cell." [GOC:dph, GOC:tb]
synonym: "hair cell morphogenesis" BROAD [GO:dph]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 CL:0000202 ! results in morphogenesis of auditory hair cell
relationship: in_taxon NCBITaxon:89593 ! Craniata
relationship: part_of GO:0042472 ! inner ear morphogenesis
relationship: part_of GO:0060117 ! auditory receptor cell development
relationship: RO:0002298 CL:0000202 ! results in morphogenesis of auditory hair cell
[Term]
id: GO:0002117
name: amphibian larval development
def: "The process whose specific outcome is the progression of the amphibian larva over time, from its formation to the mature structure. Amphibian larvae, sometimes called pollywogs or tadpoles, hatch from eggs and begin to grow limbs and other adult physical features at various times, depending on the species, before they metamorphose into the adult form." [GOC:bf, PMID:27143402]
is_a: GO:0002164 ! larval development
relationship: in_taxon NCBITaxon:131567 ! cellular organism
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
[Term]
id: GO:0002119
name: nematode larval development
def: "The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:ems, GOC:kmv]
is_a: GO:0002164 ! larval development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0009850 ! results in development of nematode larva
relationship: in_taxon NCBITaxon:33213 ! Bilateria
relationship: RO:0002296 UBERON:0009850 ! results in development of nematode larva
[Term]
id: GO:0002158
name: osteoclast proliferation
def: "The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes." [CL:0000092, GOC:hjd]
is_a: GO:0070661 ! leukocyte proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000092 ! acts on population of osteoclast
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0012003 CL:0000092 ! acts on population of osteoclast
created_by: hjd
creation_date: 2010-02-03T01:50:37Z
[Term]
id: GO:0002159
name: desmosome assembly
def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd, ISBN:0198506732]
comment: Desmosomes link two cells together; hemidesmosomes attach one cell to the extracellular matrix.
is_a: GO:0002934 ! desmosome organization
is_a: GO:0007043 ! cell-cell junction assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0030057 ! results in assembly of desmosome
relationship: never_in_taxon NCBITaxon:4751 ! Fungi
relationship: RO:0002588 GO:0030057 ! results in assembly of desmosome
created_by: hjd
creation_date: 2010-02-09T10:46:30Z
[Term]
id: GO:0002164
name: larval development
def: "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters." [GOC:jid, ISBN:0877795088]
is_a: GO:0007275 ! multicellular organism development
is_a: GO:0009791 ! post-embryonic development
relationship: in_taxon NCBITaxon:131567 ! cellular organism
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
[Term]
id: GO:0002165
name: instar larval or pupal development
def: "The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu]
is_a: GO:0007275 ! multicellular organism development
is_a: GO:0009791 ! post-embryonic development
relationship: in_taxon NCBITaxon:6656 ! Arthropoda
[Term]
id: GO:0002168
name: instar larval development
def: "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
is_a: GO:0002164 ! larval development
is_a: GO:0002165 ! instar larval or pupal development
relationship: in_taxon NCBITaxon:6656 ! Arthropoda
[Term]
id: GO:0002176
name: male germ cell proliferation
def: "The multiplication or reproduction of male germ cells, resulting in the expansion of a cell population." [GOC:hjd]
is_a: GO:0036093 ! germ cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000015 ! acts on population of male germ cell
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4751 ! Fungi
relationship: RO:0012003 CL:0000015 ! acts on population of male germ cell
created_by: hjd
creation_date: 2010-11-18T02:35:14Z
[Term]
id: GO:0002181
name: cytoplasmic translation
def: "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]
comment: Note that this term applies to translation performed by cytoplasmic ribosomes, which is distinct from translation performed by organellar ribosomes. For mitochondrial translation, consider GO:0032543 'mitochondrial translation' or its child terms.
subset: goslim_generic
subset: goslim_pombe
subset: goslim_yeast
is_a: GO:0006412 ! translation
intersection_of: GO:0006412 ! translation
intersection_of: RO:0002608 GO:0022626 ! process has causal agent cytosolic ribosome
relationship: in_taxon NCBITaxon:131567 ! cellular organism
relationship: RO:0002608 GO:0022626 ! process has causal agent cytosolic ribosome
created_by: hjd
creation_date: 2011-06-09T03:11:53Z
[Term]
id: GO:0002182
name: cytoplasmic translational elongation
def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm." [GOC:hjd]
is_a: GO:0006414 ! translational elongation
intersection_of: GO:0006414 ! translational elongation
intersection_of: part_of GO:0002181 ! cytoplasmic translation
relationship: in_taxon NCBITaxon:131567 ! cellular organism
relationship: part_of GO:0002181 ! cytoplasmic translation
created_by: hjd
creation_date: 2011-06-09T03:14:42Z
[Term]
id: GO:0002183
name: cytoplasmic translational initiation
def: "The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:hjd]
is_a: GO:0006413 ! translational initiation
intersection_of: GO:0006413 ! translational initiation
intersection_of: part_of GO:0002181 ! cytoplasmic translation
relationship: in_taxon NCBITaxon:131567 ! cellular organism
relationship: part_of GO:0002181 ! cytoplasmic translation
created_by: hjd
creation_date: 2011-06-09T03:15:48Z
[Term]
id: GO:0002184
name: cytoplasmic translational termination
def: "The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon." [GOC:hjd]
is_a: GO:0006415 ! translational termination
intersection_of: GO:0006415 ! translational termination
intersection_of: BFO:0000066 GO:0005829 ! occurs in cytosol
relationship: BFO:0000066 GO:0005829 ! occurs in cytosol
relationship: in_taxon NCBITaxon:131567 ! cellular organism
relationship: part_of GO:0002181 ! cytoplasmic translation
created_by: hjd
creation_date: 2011-06-09T03:17:13Z
[Term]
id: GO:0002200
name: somatic diversification of immune receptors
def: "The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences." [GOC:add, ISBN:0781735149, PMID:16102575, PMID:16166509]
comment: Note that this process covers somatic recombination, gene conversion, hypermutation, N-region addition, and alternate splicing processes of immune receptor diversification.
is_a: GO:0002376 ! immune system process
relationship: in_taxon NCBITaxon:131567 ! cellular organism
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4895
relationship: never_in_taxon NCBITaxon:4932
relationship: part_of GO:0002520 ! immune system development
[Term]
id: GO:0002204
name: somatic recombination of immunoglobulin genes involved in immune response
def: "The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response." [GOC:add, ISBN:0781735149]
synonym: "somatic recombination of antibody genes during immune response" RELATED []
synonym: "somatic recombination of immunoglobulin genes during immune response" RELATED [GOC:dph]
is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response
is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
[Term]
id: GO:0002208
name: somatic diversification of immunoglobulins involved in immune response
def: "The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response." [GOC:add, ISBN:0781735149, PMID:14991701]
synonym: "somatic diversification of antibodies during immune response" RELATED []
synonym: "somatic diversification of immunoglobulins during immune response" RELATED [GOC:dph]
is_a: GO:0016445 ! somatic diversification of immunoglobulins
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin-mediated immune response
[Term]
id: GO:0002213
name: defense response to insect
alt_id: GO:0002214
def: "A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism." [GOC:add]
synonym: "physiological defense response to insect" EXACT []
is_a: GO:0006952 ! defense response
is_a: GO:0051707 ! response to other organism
intersection_of: GO:0006952 ! defense response
intersection_of: RO:0004009 NCBITaxon:50557 ! has primary input Insecta
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0004009 NCBITaxon:50557 ! has primary input Insecta
[Term]
id: GO:0002215
name: defense response to nematode
alt_id: GO:0002216
def: "A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:add, PMID:11516579, PMID:14506883]
synonym: "physiological defense response to nematode" EXACT []
is_a: GO:0006952 ! defense response
is_a: GO:0051707 ! response to other organism
intersection_of: GO:0006952 ! defense response
intersection_of: RO:0004009 NCBITaxon:6231 ! has primary input Nematoda
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0004009 NCBITaxon:6231 ! has primary input Nematoda
[Term]
id: GO:0002225
name: positive regulation of antimicrobial peptide production
def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production." [GOC:add, PMID:11807545]
synonym: "activation of antimicrobial peptide production" NARROW []
synonym: "antimicrobial peptide induction" EXACT []
synonym: "stimulation of antimicrobial peptide production" NARROW []
synonym: "up regulation of antimicrobial peptide production" EXACT []
synonym: "up-regulation of antimicrobial peptide production" EXACT []
synonym: "upregulation of antimicrobial peptide production" EXACT []
is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response
is_a: GO:0002760 ! positive regulation of antimicrobial humoral response
is_a: GO:0002784 ! regulation of antimicrobial peptide production
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002775 ! positively regulates antimicrobial peptide production
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002213 GO:0002775 ! positively regulates antimicrobial peptide production
[Term]
id: GO:0002227
name: innate immune response in mucosa
def: "Any process of the innate immune response that takes place in the mucosal tissues." [GOC:add, PMID:10719665, PMID:15971105]
is_a: GO:0002385 ! mucosal immune response
is_a: GO:0045087 ! innate immune response
intersection_of: GO:0045087 ! innate immune response
intersection_of: BFO:0000066 UBERON:0000344 ! occurs in mucosa
relationship: BFO:0000066 UBERON:0000344 ! occurs in mucosa
relationship: in_taxon NCBITaxon:7711 ! Chordata
[Term]
id: GO:0002228
name: natural killer cell mediated immunity
def: "The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "NK cell mediated immunity" EXACT []
is_a: GO:0002449 ! lymphocyte mediated immunity
is_a: GO:0045087 ! innate immune response
intersection_of: GO:0002376 ! immune system process
intersection_of: RO:0002608 CL:0000623 ! process has causal agent natural killer cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002608 CL:0000623 ! process has causal agent natural killer cell
[Term]
id: GO:0002232
name: leukocyte chemotaxis involved in inflammatory response
def: "The movement of an immune cell in response to an external stimulus contributing to an inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "immune cell chemotaxis during inflammatory response" RELATED []
synonym: "leucocyte chemotaxis during inflammatory response" RELATED []
synonym: "leukocyte chemotaxis during inflammatory response" RELATED [GOC:dph]
is_a: GO:0002523 ! leukocyte migration involved in inflammatory response
is_a: GO:0030595 ! leukocyte chemotaxis
intersection_of: GO:0030595 ! leukocyte chemotaxis
intersection_of: part_of GO:0006954 ! inflammatory response
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0006954 ! inflammatory response
[Term]
id: GO:0002233
name: leukocyte chemotaxis involved in immune response
def: "The movement of an immune cell in response to an external stimulus a part of an immune response." [GOC:add, ISBN:0781735149]
synonym: "immune cell chemotaxis during immune response" EXACT []
synonym: "leucocyte chemotaxis during immune response" EXACT []
is_a: GO:0002522 ! leukocyte migration involved in immune response
is_a: GO:0030595 ! leukocyte chemotaxis
intersection_of: GO:0030595 ! leukocyte chemotaxis
intersection_of: part_of GO:0006955 ! immune response
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0006955 ! immune response
[Term]
id: GO:0002244
name: hematopoietic progenitor cell differentiation
def: "The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells." [GOC:add, GOC:rl, ISBN:0781735149, PMID:16551251]
synonym: "haematopoietic progenitor cell differentiation" EXACT []
synonym: "haemopoietic progenitor cell differentiation" EXACT []
synonym: "hemopoietic progenitor cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0008001 ! results in acquisition of features of hematopoietic precursor cell
relationship: in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of GO:0030097 ! hemopoiesis
relationship: RO:0002315 CL:0008001 ! results in acquisition of features of hematopoietic precursor cell
[Term]
id: GO:0002246
name: wound healing involved in inflammatory response
def: "The series of events that restore integrity to damaged tissue that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871]
synonym: "healing during inflammatory response" RELATED [GOC:dph]
synonym: "inflammatory response wound healing" RELATED [GOC:dph]
is_a: GO:0042060 ! wound healing
intersection_of: GO:0042060 ! wound healing
intersection_of: part_of GO:0006954 ! inflammatory response
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0006954 ! inflammatory response
relationship: part_of GO:0090594 ! inflammatory response to wounding
[Term]
id: GO:0002250
name: adaptive immune response
def: "An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory)." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "acquired immune response" EXACT [ISBN:068340007X]
synonym: "immune memory response" EXACT [GOC:add]
xref: Reactome:R-HSA-1280218 "Adaptive Immune System"
xref: Wikipedia:Adaptive_immune_system
is_a: GO:0006955 ! immune response
relationship: in_taxon NCBITaxon:33208 ! Metazoa
[Term]
id: GO:0002251
name: organ or tissue specific immune response
def: "An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues." [GO_REF:0000022, GOC:jal]
synonym: "immune response in organ or tissue" EXACT []
is_a: GO:0006955 ! immune response
relationship: never_in_taxon NCBITaxon:4895
[Term]
id: GO:0002252
name: immune effector process
def: "Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation." [GO_REF:0000022, GOC:add, ISBN:0781735149]
is_a: GO:0002376 ! immune system process
relationship: never_in_taxon NCBITaxon:4895
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/18737" xsd:anyURI
[Term]
id: GO:0002260
name: lymphocyte homeostasis
def: "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15826826, PMID:16319493, PMID:16551252, PMID:16551262]
is_a: GO:0001776 ! leukocyte homeostasis
intersection_of: GO:0048872 ! homeostasis of number of cells
intersection_of: RO:0012003 CL:0000542 ! acts on population of lymphocyte
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0012003 CL:0000542 ! acts on population of lymphocyte
[Term]
id: GO:0002262
name: myeloid cell homeostasis
def: "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000763, GOC:add]
is_a: GO:0002376 ! immune system process
is_a: GO:0048872 ! homeostasis of number of cells
intersection_of: GO:0048872 ! homeostasis of number of cells
intersection_of: RO:0012003 CL:0000763 ! acts on population of myeloid cell
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4895
relationship: never_in_taxon NCBITaxon:4932
relationship: RO:0012003 CL:0000763 ! acts on population of myeloid cell
[Term]
id: GO:0002263
name: cell activation involved in immune response
def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0001775 ! cell activation
is_a: GO:0002252 ! immune effector process
intersection_of: GO:0001775 ! cell activation
intersection_of: part_of GO:0006955 ! immune response
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: part_of GO:0006955 ! immune response
[Term]
id: GO:0002264
name: endothelial cell activation involved in immune response
def: "A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "endothelial cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0002263 ! cell activation involved in immune response
is_a: GO:0042118 ! endothelial cell activation
intersection_of: GO:0042118 ! endothelial cell activation
intersection_of: part_of GO:0006955 ! immune response
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: part_of GO:0006955 ! immune response
[Term]
id: GO:0002265
name: astrocyte activation involved in immune response
def: "A change in the morphology or behavior of an astrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:11138785]
synonym: "astrocyte activation during immune response" RELATED [GOC:tb]
is_a: GO:0002263 ! cell activation involved in immune response
is_a: GO:0048143 ! astrocyte activation
intersection_of: GO:0048143 ! astrocyte activation
intersection_of: part_of GO:0006955 ! immune response
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0006955 ! immune response
[Term]
id: GO:0002269
name: leukocyte activation involved in inflammatory response
def: "A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "immune cell activation during inflammatory response" RELATED []
synonym: "leukocyte activation during inflammatory response" RELATED [GOC:tb]
is_a: GO:0045321 ! leukocyte activation
intersection_of: GO:0045321 ! leukocyte activation
intersection_of: part_of GO:0006954 ! inflammatory response
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0006954 ! inflammatory response
[Term]
id: GO:0002274
name: myeloid leukocyte activation
def: "A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, ISBN:0781735149]
synonym: "myeloid leucocyte activation" EXACT []
is_a: GO:0045321 ! leukocyte activation
intersection_of: GO:0001775 ! cell activation
intersection_of: RO:0004009 CL:0000766 ! has primary input myeloid leukocyte
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0004009 CL:0000766 ! has primary input myeloid leukocyte
[Term]
id: GO:0002275
name: myeloid cell activation involved in immune response
def: "A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "myeloid cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0002274 ! myeloid leukocyte activation
is_a: GO:0002366 ! leukocyte activation involved in immune response
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
[Term]
id: GO:0002277
name: myeloid dendritic cell activation involved in immune response
def: "The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "myeloid dendritic cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0001773 ! myeloid dendritic cell activation
is_a: GO:0002275 ! myeloid cell activation involved in immune response
intersection_of: GO:0001773 ! myeloid dendritic cell activation
intersection_of: part_of GO:0006955 ! immune response
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0006955 ! immune response
[Term]
id: GO:0002280
name: monocyte activation involved in immune response
def: "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149, PMID:16551245]
synonym: "monocyte activation during immune response" RELATED [GOC:tb]
is_a: GO:0002275 ! myeloid cell activation involved in immune response
is_a: GO:0042117 ! monocyte activation
intersection_of: GO:0042117 ! monocyte activation
intersection_of: part_of GO:0006955 ! immune response
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0006955 ! immune response
[Term]
id: GO:0002281
name: macrophage activation involved in immune response
def: "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "macrophage activation during immune response" RELATED [GOC:tb]
synonym: "macrophage polarization involved in immune response" EXACT []
is_a: GO:0002366 ! leukocyte activation involved in immune response
is_a: GO:0042116 ! macrophage activation
intersection_of: GO:0042116 ! macrophage activation
intersection_of: part_of GO:0006955 ! immune response
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0002275 ! myeloid cell activation involved in immune response
relationship: part_of GO:0006955 ! immune response
[Term]
id: GO:0002283
name: neutrophil activation involved in immune response
def: "The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "neutrophil activation during immune response" RELATED [GOC:tb]
is_a: GO:0002275 ! myeloid cell activation involved in immune response
is_a: GO:0042119 ! neutrophil activation
intersection_of: GO:0042119 ! neutrophil activation
intersection_of: part_of GO:0006955 ! immune response
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0006955 ! immune response
[Term]
id: GO:0002284
name: myeloid dendritic cell differentiation involved in immune response
def: "The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response." [GOC:add, ISBN:0781735149]
synonym: "myeloid dendritic cell differentiation during immune response" RELATED [GOC:tb]
is_a: GO:0002277 ! myeloid dendritic cell activation involved in immune response
is_a: GO:0043011 ! myeloid dendritic cell differentiation
intersection_of: GO:0043011 ! myeloid dendritic cell differentiation
intersection_of: part_of GO:0006955 ! immune response
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0006955 ! immune response
[Term]
id: GO:0002285
name: lymphocyte activation involved in immune response
def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "lymphocyte activation during immune response" RELATED [GOC:tb]
is_a: GO:0002366 ! leukocyte activation involved in immune response
is_a: GO:0046649 ! lymphocyte activation
intersection_of: GO:0046649 ! lymphocyte activation
intersection_of: part_of GO:0006955 ! immune response
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0006955 ! immune response
[Term]
id: GO:0002286
name: T cell activation involved in immune response
def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "T cell activation during immune response" RELATED [GOC:tb]
synonym: "T lymphocyte activation during immune response" RELATED []
synonym: "T-cell activation during immune response" RELATED []
synonym: "T-lymphocyte activation during immune response" RELATED []
is_a: GO:0002285 ! lymphocyte activation involved in immune response
is_a: GO:0042110 ! T cell activation
intersection_of: GO:0042110 ! T cell activation
intersection_of: part_of GO:0006955 ! immune response
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0006955 ! immune response
[Term]
id: GO:0002292
name: T cell differentiation involved in immune response
def: "The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "T cell development involved in immune response" RELATED [GOC:add]
synonym: "T cell differentiation during immune response" RELATED [GOC:tb]
synonym: "T lymphocyte differentiation during immune response" RELATED []
synonym: "T-cell differentiation during immune response" RELATED []
synonym: "T-lymphocyte differentiation during immune response" RELATED []
is_a: GO:0002286 ! T cell activation involved in immune response
is_a: GO:0030217 ! T cell differentiation
intersection_of: GO:0030217 ! T cell differentiation
intersection_of: part_of GO:0006955 ! immune response
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0006955 ! immune response
[Term]
id: GO:0002309
name: T cell proliferation involved in immune response
def: "The expansion of a T cell population by cell division as part of an immune response." [GOC:add, ISBN:0781735149]
synonym: "T cell proliferation during immune response" RELATED [GOC:tb]
synonym: "T lymphocyte proliferation during immune response" RELATED []
synonym: "T-cell proliferation during immune response" RELATED []
synonym: "T-lymphocyte proliferation during immune response" RELATED []
is_a: GO:0002286 ! T cell activation involved in immune response
is_a: GO:0042098 ! T cell proliferation
intersection_of: GO:0042098 ! T cell proliferation
intersection_of: part_of GO:0006955 ! immune response
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0006955 ! immune response
[Term]
id: GO:0002312
name: B cell activation involved in immune response
def: "The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:jal]
synonym: "B cell activation during immune response" RELATED [GOC:tb]
synonym: "B lymphocyte activation during immune response" RELATED []
synonym: "B-cell activation during immune response" RELATED []
synonym: "B-lymphocyte activation during immune response" RELATED []
is_a: GO:0002285 ! lymphocyte activation involved in immune response
is_a: GO:0042113 ! B cell activation
intersection_of: GO:0042113 ! B cell activation
intersection_of: part_of GO:0006955 ! immune response
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0006955 ! immune response
[Term]
id: GO:0002313
name: mature B cell differentiation involved in immune response
def: "The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response." [GOC:jal]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "mature B cell development involved in immune response" RELATED [GOC:add]
synonym: "mature B cell differentiation during immune response" RELATED [GOC:tb]
synonym: "mature B lymphocyte differentiation during immune response" RELATED []
synonym: "mature B-cell differentiation during immune response" RELATED []
synonym: "mature B-lymphocyte differentiation during immune response" RELATED []
is_a: GO:0002312 ! B cell activation involved in immune response
is_a: GO:0002335 ! mature B cell differentiation
intersection_of: GO:0002335 ! mature B cell differentiation
intersection_of: part_of GO:0006955 ! immune response
relationship: in_taxon NCBITaxon:40674 ! Mammalia
relationship: part_of GO:0006955 ! immune response
[Term]
id: GO:0002314
name: germinal center B cell differentiation
def: "The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA)." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "germinal center B cell development" RELATED [GOC:add]
synonym: "germinal center B lymphocyte differentiation" EXACT []
synonym: "germinal center B-cell differentiation" EXACT []
synonym: "germinal center B-lymphocyte differentiation" EXACT []
is_a: GO:0002313 ! mature B cell differentiation involved in immune response
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000844 ! results in acquisition of features of germinal center B cell
relationship: in_taxon NCBITaxon:40674 ! Mammalia
relationship: RO:0002315 CL:0000844 ! results in acquisition of features of germinal center B cell
[Term]
id: GO:0002316
name: follicular B cell differentiation
def: "The process in which a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "follicular B cell development" RELATED [GOC:add]
synonym: "follicular B lymphocyte differentiation" EXACT []
synonym: "follicular B-cell differentiation" EXACT []
synonym: "follicular B-lymphocyte differentiation" EXACT []
is_a: GO:0002313 ! mature B cell differentiation involved in immune response
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000843 ! results in acquisition of features of follicular B cell
relationship: in_taxon NCBITaxon:40674 ! Mammalia
relationship: RO:0002315 CL:0000843 ! results in acquisition of features of follicular B cell
[Term]
id: GO:0002317
name: plasma cell differentiation
def: "The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody." [GOC:jal]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "plasma cell development" RELATED [GOC:add]
is_a: GO:0002313 ! mature B cell differentiation involved in immune response
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000786 ! results in acquisition of features of plasma cell
relationship: in_taxon NCBITaxon:40674 ! Mammalia
relationship: RO:0002315 CL:0000786 ! results in acquisition of features of plasma cell
[Term]
id: GO:0002318
name: myeloid progenitor cell differentiation
def: "The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages." [GOC:add, PMID:16551264]
is_a: GO:0002244 ! hematopoietic progenitor cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000839 ! results in acquisition of features of myeloid lineage restricted progenitor cell
relationship: in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: RO:0002315 CL:0000839 ! results in acquisition of features of myeloid lineage restricted progenitor cell
[Term]
id: GO:0002319
name: memory B cell differentiation
def: "The process in which a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "memory B cell development" RELATED [GOC:add]
synonym: "memory B lymphocyte differentiation" EXACT []
synonym: "memory B-cell differentiation" EXACT []
synonym: "memory B-lymphocyte differentiation" EXACT []
is_a: GO:0002313 ! mature B cell differentiation involved in immune response
is_a: GO:0090715 ! immunological memory formation process
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000787 ! results in acquisition of features of memory B cell
relationship: in_taxon NCBITaxon:40674 ! Mammalia
relationship: RO:0002315 CL:0000787 ! results in acquisition of features of memory B cell
[Term]
id: GO:0002320
name: lymphoid progenitor cell differentiation
def: "The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages." [GOC:add, PMID:16551251, PMID:16551264]
is_a: GO:0002244 ! hematopoietic progenitor cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000838 ! results in acquisition of features of lymphoid lineage restricted progenitor cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002315 CL:0000838 ! results in acquisition of features of lymphoid lineage restricted progenitor cell
[Term]
id: GO:0002321
name: natural killer cell progenitor differentiation
def: "The process in which a precursor cell type acquires the specialized features of a natural killer cell progenitor." [GOC:add, PMID:16551251, PMID:16551264]
is_a: GO:0002320 ! lymphoid progenitor cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000825 ! results in acquisition of features of pro-NK cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002315 CL:0000825 ! results in acquisition of features of pro-NK cell
[Term]
id: GO:0002322
name: B cell proliferation involved in immune response
def: "The expansion of a B cell population by cell division following B cell activation during an immune response." [GOC:jal]
synonym: "B cell proliferation during immune response" RELATED [GOC:tb]
synonym: "B lymphocyte proliferation during immune response" RELATED []
synonym: "B-cell proliferation during immune response" RELATED []
synonym: "B-lymphocyte proliferation during immune response" RELATED []
is_a: GO:0002312 ! B cell activation involved in immune response
is_a: GO:0042100 ! B cell proliferation
intersection_of: GO:0042100 ! B cell proliferation
intersection_of: part_of GO:0006955 ! immune response
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0006955 ! immune response
[Term]
id: GO:0002323
name: natural killer cell activation involved in immune response
def: "The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15032583]
synonym: "natural killer cell activation during immune response" RELATED [GOC:tb]
synonym: "NK cell activation during immune response" RELATED []
is_a: GO:0002285 ! lymphocyte activation involved in immune response
is_a: GO:0030101 ! natural killer cell activation
intersection_of: GO:0030101 ! natural killer cell activation
intersection_of: part_of GO:0045087 ! innate immune response
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0045087 ! innate immune response
[Term]
id: GO:0002324
name: natural killer cell proliferation involved in immune response
def: "The expansion of a natural killer cell population by cell division as part of an immune response." [GOC:add, PMID:15032583]
synonym: "natural killer cell proliferation during immune response" RELATED [GOC:tb]
synonym: "NK cell proliferation during immune response" RELATED []
is_a: GO:0001787 ! natural killer cell proliferation
is_a: GO:0002285 ! lymphocyte activation involved in immune response
intersection_of: GO:0001787 ! natural killer cell proliferation
intersection_of: part_of GO:0006955 ! immune response
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0006955 ! immune response
[Term]
id: GO:0002325
name: natural killer cell differentiation involved in immune response
def: "The process in which a naive natural killer cell acquires the specialized features of an effector natural killer T cell as part of an immune response." [GOC:add, PMID:11698225]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "natural killer cell development involved in immune response" RELATED [GOC:add]
synonym: "natural killer cell differentiation during immune response" RELATED [GOC:tb]
synonym: "NK cell differentiation during immune response" RELATED []
is_a: GO:0001779 ! natural killer cell differentiation
is_a: GO:0002285 ! lymphocyte activation involved in immune response
intersection_of: GO:0001779 ! natural killer cell differentiation
intersection_of: part_of GO:0006955 ! immune response
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0006955 ! immune response
[Term]
id: GO:0002327
name: immature B cell differentiation
def: "The process in which a precursor cell type acquires the specialized features of an immature B cell." [GOC:jal, ISBN:0781735149, PMID:16551251]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "immature B cell development" RELATED [GOC:add]
synonym: "immature B lymphocyte differentiation" EXACT []
synonym: "immature B-cell differentiation" EXACT []
synonym: "immature B-lymphocyte differentiation" EXACT []
is_a: GO:0030183 ! B cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000816 ! results in acquisition of features of immature B cell
relationship: in_taxon NCBITaxon:40674 ! Mammalia
relationship: RO:0002315 CL:0000816 ! results in acquisition of features of immature B cell
[Term]
id: GO:0002328
name: pro-B cell differentiation
def: "The process in which a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed." [GOC:jal, ISBN:0781735149]
synonym: "pro-B cell development" RELATED [GOC:add]
synonym: "pro-B lymphocyte differentiation" EXACT []
is_a: GO:0002320 ! lymphoid progenitor cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000826 ! results in acquisition of features of pro-B cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002315 CL:0000826 ! results in acquisition of features of pro-B cell
[Term]
id: GO:0002329
name: pre-B cell differentiation
def: "The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "pre-B cell development" RELATED [GOC:add]
synonym: "pre-B lymphocyte differentiation" EXACT []
is_a: GO:0002327 ! immature B cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000817 ! results in acquisition of features of precursor B cell
relationship: in_taxon NCBITaxon:40674 ! Mammalia
relationship: RO:0002315 CL:0000817 ! results in acquisition of features of precursor B cell
[Term]
id: GO:0002332
name: transitional stage B cell differentiation
def: "The process in which immature B cells from the bone marrow become mature B cells in the spleen. Transitional stage B cells are subdivided into transitional one (T1) and transitional two (T2) stages and are short-lived and functionally incompetent." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "transitional stage B cell development" RELATED [GOC:add]
synonym: "transitional stage B lymphocyte differentiation" EXACT []
synonym: "transitional stage B-cell differentiation" EXACT []
synonym: "transitional stage B-lymphocyte differentiation" EXACT []
is_a: GO:0002327 ! immature B cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000818 ! results in acquisition of features of transitional stage B cell
relationship: in_taxon NCBITaxon:40674 ! Mammalia
relationship: RO:0002315 CL:0000818 ! results in acquisition of features of transitional stage B cell
[Term]
id: GO:0002335
name: mature B cell differentiation
def: "The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "mature B lymphocyte differentiation" EXACT []
synonym: "mature B-cell differentiation" EXACT []
synonym: "mature B-lymphocyte differentiation" EXACT []
synonym: "mature cell development" RELATED [GOC:add]
is_a: GO:0030183 ! B cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000785 ! results in acquisition of features of mature B cell
relationship: in_taxon NCBITaxon:40674 ! Mammalia
relationship: RO:0002315 CL:0000785 ! results in acquisition of features of mature B cell
[Term]
id: GO:0002337
name: B-1a B cell differentiation
def: "The process in which B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "B-1a B cell development" RELATED [GOC:add]
synonym: "B-1a B lymphocyte differentiation" EXACT []
synonym: "B-1a B-cell differentiation" EXACT []
synonym: "B-1a B-lymphocyte differentiation" EXACT []
is_a: GO:0001923 ! B-1 B cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000820 ! results in acquisition of features of B-1a B cell
relationship: in_taxon NCBITaxon:40674 ! Mammalia
relationship: RO:0002315 CL:0000820 ! results in acquisition of features of B-1a B cell
[Term]
id: GO:0002338
name: B-1b B cell differentiation
def: "The process in which B cells acquire the specialized features of B-1b B cells. B-1b B cells are B-1 cells that do not express CD5." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "B-1b B cell development" RELATED [GOC:add]
synonym: "B-1b B lymphocyte differentiation" EXACT []
synonym: "B-1b B-cell differentiation" EXACT []
synonym: "B-1b B-lymphocyte differentiation" EXACT []
is_a: GO:0001923 ! B-1 B cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000821 ! results in acquisition of features of B-1b B cell
relationship: in_taxon NCBITaxon:40674 ! Mammalia
relationship: RO:0002315 CL:0000821 ! results in acquisition of features of B-1b B cell
[Term]
id: GO:0002339
name: B cell selection
def: "The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival." [GOC:jal]
synonym: "B lymphocyte selection" EXACT []
synonym: "B-cell selection" EXACT []
synonym: "B-lymphocyte selection" EXACT []
is_a: GO:0002376 ! immune system process
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0030183 ! B cell differentiation
relationship: RO:0000057 CL:0000236 ! has participant B cell
[Term]
id: GO:0002343
name: peripheral B cell selection
def: "Any B cell selection process that occurs in the periphery." [GOC:jal]
synonym: "peripheral B lymphocyte selection" EXACT []
synonym: "peripheral B-cell selection" EXACT []
synonym: "peripheral B-lymphocyte selection" EXACT []
is_a: GO:0002339 ! B cell selection
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
[Term]
id: GO:0002344
name: B cell affinity maturation
def: "The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen." [GO_REF:0000022, GOC:jal, ISBN:0781735149]
synonym: "B lymphocyte affinity maturation" EXACT []
synonym: "B-cell affinity maturation" EXACT []
synonym: "B-lymphocyte affinity maturation" EXACT []
is_a: GO:0002343 ! peripheral B cell selection
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin-mediated immune response
[Term]
id: GO:0002349
name: histamine production involved in inflammatory response
def: "The synthesis or release of histamine following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:16730260]
synonym: "histamine production involved in acute inflammatory response" BROAD []
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
[Term]
id: GO:0002351
name: serotonin production involved in inflammatory response
def: "The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:16730260]
synonym: "serotonin production involved in acute inflammatory response" BROAD []
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
[Term]
id: GO:0002358
name: B cell homeostatic proliferation
def: "The non-specific expansion of B cell populations within a whole or part of an organism to reach to a total number of B cells which will then remain stable over time in the absence of an external stimulus." [GOC:jal]
synonym: "B lymphocyte homeostatic proliferation" EXACT []
synonym: "B-cell homeostatic proliferation" EXACT []
synonym: "B-lymphocyte homeostatic proliferation" EXACT []
is_a: GO:0042100 ! B cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: part_of GO:0042592 ! homeostatic process
intersection_of: RO:0012003 CL:0000236 ! acts on population of B cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0042592 ! homeostatic process
relationship: RO:0012003 CL:0000236 ! acts on population of B cell
[Term]
id: GO:0002359
name: B-1 B cell proliferation
def: "The expansion of a B-1 B cell by cell division. Follows B cell activation." [GOC:jal]
synonym: "B-1 B lymphocyte proliferation" EXACT []
synonym: "B-1 B-cell proliferation" EXACT []
synonym: "B-1 B-lymphocyte proliferation" EXACT []
is_a: GO:0042100 ! B cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000819 ! acts on population of B-1 B cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0012003 CL:0000819 ! acts on population of B-1 B cell
[Term]
id: GO:0002366
name: leukocyte activation involved in immune response
def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "immune cell activation during immune response" RELATED []
synonym: "leucocyte activation during immune response" RELATED []
synonym: "leukocyte activation during immune response" RELATED [GOC:tb]
is_a: GO:0002263 ! cell activation involved in immune response
is_a: GO:0045321 ! leukocyte activation
intersection_of: GO:0045321 ! leukocyte activation
intersection_of: part_of GO:0006955 ! immune response
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0006955 ! immune response
[Term]
id: GO:0002367
name: cytokine production involved in immune response
alt_id: GO:0002374
alt_id: GO:0002375
def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "cytokine biosynthetic process involved in immune response" NARROW []
synonym: "cytokine production during immune response" RELATED [GOC:dph]
synonym: "cytokine secretion during immune response" RELATED [GOC:dph]
synonym: "cytokine secretion involved in immune response" RELATED []
is_a: GO:0001816 ! cytokine production
is_a: GO:0002440 ! production of molecular mediator of immune response
intersection_of: GO:0001816 ! cytokine production
intersection_of: part_of GO:0006955 ! immune response
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4895
relationship: never_in_taxon NCBITaxon:4932
relationship: part_of GO:0006955 ! immune response
[Term]
id: GO:0002368
name: B cell cytokine production
def: "Any process that contributes to cytokine production by a B cell." [GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "B lymphocyte cytokine production" EXACT []
synonym: "B-cell cytokine production" EXACT []
synonym: "B-lymphocyte cytokine production" EXACT []
is_a: GO:0002367 ! cytokine production involved in immune response
is_a: GO:0019724 ! B cell mediated immunity
intersection_of: GO:0001816 ! cytokine production
intersection_of: RO:0002608 CL:0000236 ! process has causal agent B cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002608 CL:0000236 ! process has causal agent B cell
[Term]
id: GO:0002369
name: T cell cytokine production
def: "Any process that contributes to cytokine production by a T cell." [GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "T lymphocyte cytokine production" EXACT []
synonym: "T-cell cytokine production" EXACT []
synonym: "T-lymphocyte cytokine production" EXACT []
is_a: GO:0002367 ! cytokine production involved in immune response
is_a: GO:0002456 ! T cell mediated immunity
intersection_of: GO:0001816 ! cytokine production
intersection_of: RO:0002608 CL:0000084 ! process has causal agent T cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002608 CL:0000084 ! process has causal agent T cell
[Term]
id: GO:0002370
name: natural killer cell cytokine production
def: "Any process that contributes to cytokine production by a natural killer cell." [GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "NK cell cytokine production" EXACT []
is_a: GO:0002228 ! natural killer cell mediated immunity
is_a: GO:0002367 ! cytokine production involved in immune response
intersection_of: GO:0001816 ! cytokine production
intersection_of: RO:0002608 CL:0000623 ! process has causal agent natural killer cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002608 CL:0000623 ! process has causal agent natural killer cell
[Term]
id: GO:0002371
name: dendritic cell cytokine production
def: "Any process that contributes to cytokine production by a dendritic cell." [GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002367 ! cytokine production involved in immune response
is_a: GO:0002443 ! leukocyte mediated immunity
intersection_of: GO:0001816 ! cytokine production
intersection_of: RO:0002608 CL:0000451 ! process has causal agent dendritic cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002608 CL:0000451 ! process has causal agent dendritic cell
[Term]
id: GO:0002372
name: myeloid dendritic cell cytokine production
def: "Any process that contributes to cytokine production by a myeloid dendritic cell." [GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002371 ! dendritic cell cytokine production
is_a: GO:0002444 ! myeloid leukocyte mediated immunity
is_a: GO:0061082 ! myeloid leukocyte cytokine production
intersection_of: GO:0001816 ! cytokine production
intersection_of: RO:0002608 CL:0000782 ! process has causal agent myeloid dendritic cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002608 CL:0000782 ! process has causal agent myeloid dendritic cell
[Term]
id: GO:0002376
name: immune system process
def: "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]
comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501).
subset: goslim_agr
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_pir
xref: Wikipedia:Immune_system
is_a: GO:0008150 ! biological_process
disjoint_from: GO:0044848 ! biological phase
relationship: never_in_taxon NCBITaxon:4895
[Term]
id: GO:0002377
name: immunoglobulin production
alt_id: GO:0002378
alt_id: GO:0048305
def: "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "antibody production" EXACT []
synonym: "immunoglobulin biosynthetic process" NARROW []
synonym: "immunoglobulin secretion" NARROW []
is_a: GO:0002440 ! production of molecular mediator of immune response
relationship: never_in_taxon NCBITaxon:4895
[Term]
id: GO:0002381
name: immunoglobulin production involved in immunoglobulin-mediated immune response
alt_id: GO:0002379
alt_id: GO:0002380
def: "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:9185563]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "antibody production during immune response" RELATED []
synonym: "antibody secretion during immune response" RELATED []
synonym: "immunoglobulin biosynthetic process involved in immune response" NARROW []
synonym: "immunoglobulin production during immune response" RELATED [GOC:dph]
synonym: "immunoglobulin production involved in immune response" RELATED [GOC:dph]
synonym: "immunoglobulin production involved in immunoglobulin mediated immune response" EXACT []
synonym: "immunoglobulin secretion involved in immune response" NARROW []
is_a: GO:0002377 ! immunoglobulin production
intersection_of: GO:0002377 ! immunoglobulin production
intersection_of: part_of GO:0016064 ! immunoglobulin mediated immune response
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0016064 ! immunoglobulin mediated immune response
[Term]
id: GO:0002384
name: hepatic immune response
def: "An immune response taking place in the liver." [GO_REF:0000022, GOC:jal, ISBN:0781735149]
is_a: GO:0002251 ! organ or tissue specific immune response
intersection_of: GO:0006955 ! immune response
intersection_of: BFO:0000066 UBERON:0002107 ! occurs in liver
relationship: BFO:0000066 UBERON:0002107 ! occurs in liver
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
[Term]
id: GO:0002385
name: mucosal immune response
alt_id: GO:0002386
alt_id: GO:0002422
def: "An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract." [GO_REF:0000022, GOC:jal, ISBN:0781735149]
synonym: "immune response in MALT" NARROW []
synonym: "immune response in mucosal-associated lymphoid tissue" NARROW []
synonym: "immune response in urogenital tract" NARROW []
is_a: GO:0002251 ! organ or tissue specific immune response
relationship: never_in_taxon NCBITaxon:4895
[Term]
id: GO:0002387
name: immune response in gut-associated lymphoid tissue
def: "Immune response taking place in the gut-associated lymphoid tissue (GALT). GALT includes Peyer's patches, appendix, and solitary lymph nodules." [GOC:jal, ISBN:0781735149]
synonym: "immune response in GALT" EXACT []
is_a: GO:0006955 ! immune response
intersection_of: GO:0006955 ! immune response
intersection_of: BFO:0000066 UBERON:0001962 ! occurs in gut-associated lymphoid tissue
relationship: BFO:0000066 UBERON:0001962 ! occurs in gut-associated lymphoid tissue
relationship: never_in_taxon NCBITaxon:4895
[Term]
id: GO:0002388
name: immune response in Peyer's patch
def: "Immune response taking place in the Peyer's patch, nodular lymphoid structures on the serosal surface of the small intestine." [GOC:jal, ISBN:0781735149]
is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue
intersection_of: GO:0006955 ! immune response
intersection_of: BFO:0000066 UBERON:0001211 ! occurs in Peyer's patch
relationship: BFO:0000066 UBERON:0001211 ! occurs in Peyer's patch
relationship: in_taxon NCBITaxon:32524 ! Amniota
[Term]
id: GO:0002395
name: immune response in nasopharyngeal-associated lymphoid tissue
def: "An immune response taking place in the nasopharyngeal-associated lymphoid tissue (NALT). NALT includes the tonsils and adenoids." [GOC:jal, ISBN:0781735149]
synonym: "immune response in NALT" EXACT []
is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue
intersection_of: GO:0006955 ! immune response
intersection_of: BFO:0000066 UBERON:0012330 ! occurs in nasal-associated lymphoid tissue
relationship: BFO:0000066 UBERON:0012330 ! occurs in nasal-associated lymphoid tissue
relationship: never_in_taxon NCBITaxon:4895
[Term]
id: GO:0002396
name: MHC protein complex assembly
def: "The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678]
is_a: GO:0065003 ! protein-containing complex assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0042611 ! results in assembly of MHC protein complex
relationship: RO:0002588 GO:0042611 ! results in assembly of MHC protein complex
[Term]
id: GO:0002399
name: MHC class II protein complex assembly
def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0002396 ! MHC protein complex assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0042613 ! results in assembly of MHC class II protein complex
relationship: RO:0002588 GO:0042613 ! results in assembly of MHC class II protein complex
[Term]
id: GO:0002407
name: dendritic cell chemotaxis
def: "The movement of a dendritic cell in response to an external stimulus." [CL:0000451, GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255]
is_a: GO:0030595 ! leukocyte chemotaxis
is_a: GO:0036336 ! dendritic cell migration
intersection_of: GO:0006935 ! chemotaxis
intersection_of: RO:0002565 CL:0000451 ! results in movement of dendritic cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002565 CL:0000451 ! results in movement of dendritic cell
[Term]
id: GO:0002408
name: myeloid dendritic cell chemotaxis
def: "The movement of a myeloid dendritic cell in response to an external stimulus." [GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255]
is_a: GO:0002407 ! dendritic cell chemotaxis
is_a: GO:0097529 ! myeloid leukocyte migration
intersection_of: GO:0006935 ! chemotaxis
intersection_of: RO:0002565 CL:0000782 ! results in movement of myeloid dendritic cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002565 CL:0000782 ! results in movement of myeloid dendritic cell
[Term]
id: GO:0002409
name: Langerhans cell chemotaxis
def: "The movement of a Langerhans cell in response to an external stimulus." [GOC:add, PMID:16056255, PMID:16387601]
is_a: GO:0002408 ! myeloid dendritic cell chemotaxis
intersection_of: GO:0006935 ! chemotaxis
intersection_of: RO:0002565 CL:0000453 ! results in movement of Langerhans cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002565 CL:0000453 ! results in movement of Langerhans cell
[Term]
id: GO:0002440
name: production of molecular mediator of immune response
def: "The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "production of cellular mediator of immune response" RELATED []
is_a: GO:0002376 ! immune system process
is_a: GO:0010467 ! gene expression
relationship: never_in_taxon NCBITaxon:4895
[Term]
id: GO:0002441
name: histamine secretion involved in inflammatory response
def: "The regulated release of histamine by a cell as part of an inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "histamine secretion involved in acute inflammatory response" BROAD []
is_a: GO:0001821 ! histamine secretion
is_a: GO:0046879 ! hormone secretion
intersection_of: GO:0001821 ! histamine secretion
intersection_of: part_of GO:0006954 ! inflammatory response
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0002349 ! histamine production involved in inflammatory response
relationship: part_of GO:0006954 ! inflammatory response
[Term]
id: GO:0002442
name: serotonin secretion involved in inflammatory response
def: "The regulated release of serotonin by a cell as part of an inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "serotonin release involved in inflammatory response" RELATED [GOC:tb]
synonym: "serotonin secretion involved in acute inflammatory response" BROAD []
is_a: GO:0001820 ! serotonin secretion
intersection_of: GO:0001820 ! serotonin secretion
intersection_of: part_of GO:0006954 ! inflammatory response
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0002351 ! serotonin production involved in inflammatory response
relationship: part_of GO:0006954 ! inflammatory response
[Term]
id: GO:0002443
name: leukocyte mediated immunity
alt_id: GO:0019723
alt_id: GO:0042087
def: "Any process involved in the carrying out of an immune response by a leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "cell-mediated immune response" RELATED []
synonym: "cellular immune response" RELATED []
synonym: "immune cell effector process" EXACT []
synonym: "immune cell mediated immunity" EXACT []
synonym: "leucocyte immune effector process" EXACT []
synonym: "leucocyte mediated immunity" EXACT []
synonym: "leukocyte immune effector process" EXACT []
is_a: GO:0002252 ! immune effector process
intersection_of: GO:0002376 ! immune system process
intersection_of: RO:0002608 CL:0000738 ! process has causal agent leukocyte
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002608 CL:0000738 ! process has causal agent leukocyte
[Term]
id: GO:0002444
name: myeloid leukocyte mediated immunity
def: "Any process involved in the carrying out of an immune response by a myeloid leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "myeloid leucocyte immune effector process" EXACT []
synonym: "myeloid leucocyte mediated immunity" EXACT []
synonym: "myeloid leukocyte immune effector process" EXACT []
is_a: GO:0002443 ! leukocyte mediated immunity
intersection_of: GO:0002376 ! immune system process
intersection_of: RO:0002608 CL:0000766 ! process has causal agent myeloid leukocyte
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002608 CL:0000766 ! process has causal agent myeloid leukocyte
[Term]
id: GO:0002446
name: neutrophil mediated immunity
def: "Any process involved in the carrying out of an immune response by a neutrophil." [GO_REF:0000022, GOC:add, ISBN:0781735149]
is_a: GO:0002444 ! myeloid leukocyte mediated immunity
intersection_of: GO:0002376 ! immune system process
intersection_of: RO:0002608 CL:0000775 ! process has causal agent neutrophil
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002608 CL:0000775 ! process has causal agent neutrophil
[Term]
id: GO:0002449
name: lymphocyte mediated immunity
def: "Any process involved in the carrying out of an immune response by a lymphocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "cell-mediated immunity" BROAD []
synonym: "cellular immune response" BROAD []
is_a: GO:0002443 ! leukocyte mediated immunity
intersection_of: GO:0002376 ! immune system process
intersection_of: RO:0002608 CL:0000542 ! process has causal agent lymphocyte
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002608 CL:0000542 ! process has causal agent lymphocyte
[Term]
id: GO:0002450
name: B cell antigen processing and presentation
def: "The process in which a B cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
synonym: "B lymphocyte antigen processing and presentation" EXACT []
synonym: "B-cell antigen processing and presentation" EXACT []
synonym: "B-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0019882 ! antigen processing and presentation
intersection_of: GO:0019882 ! antigen processing and presentation
intersection_of: BFO:0000066 CL:0000236 ! occurs in B cell
relationship: BFO:0000066 CL:0000236 ! occurs in B cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0019724 ! B cell mediated immunity
[Term]
id: GO:0002456
name: T cell mediated immunity
def: "Any process involved in the carrying out of an immune response by a T cell." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "cell-mediated immunity" BROAD []
synonym: "cellular immune response" BROAD []
synonym: "T lymphocyte mediated immunity" EXACT []
synonym: "T-cell mediated immunity" EXACT []
synonym: "T-lymphocyte mediated immunity" EXACT []
is_a: GO:0002449 ! lymphocyte mediated immunity
is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0002376 ! immune system process
intersection_of: RO:0002608 CL:0000084 ! process has causal agent T cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002608 CL:0000084 ! process has causal agent T cell
[Term]
id: GO:0002457
name: T cell antigen processing and presentation
def: "The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11417857, PMID:15120183]
synonym: "T lymphocyte antigen processing and presentation" EXACT []
synonym: "T-cell antigen processing and presentation" EXACT []
synonym: "T-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0019882 ! antigen processing and presentation
intersection_of: GO:0019882 ! antigen processing and presentation
intersection_of: BFO:0000066 CL:0000084 ! occurs in T cell
relationship: BFO:0000066 CL:0000084 ! occurs in T cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0002456 ! T cell mediated immunity
[Term]
id: GO:0002460
name: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
def: "An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus." [GOC:add, GOC:mtg_sensu, ISBN:0781735149, ISBN:1405196831]
is_a: GO:0002250 ! adaptive immune response
relationship: in_taxon NCBITaxon:33208 ! Metazoa
[Term]
id: GO:0002467
name: germinal center formation
def: "The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation." [GO_REF:0000022, GOC:jal, ISBN:081533642X]
is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0001745 ! results in formation of anatomical entity secondary nodular lymphoid tissue
relationship: in_taxon NCBITaxon:40674 ! Mammalia
relationship: RO:0002297 UBERON:0001745 ! results in formation of anatomical entity secondary nodular lymphoid tissue
[Term]
id: GO:0002468
name: dendritic cell antigen processing and presentation
def: "The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0019882 ! antigen processing and presentation
intersection_of: GO:0019882 ! antigen processing and presentation
intersection_of: BFO:0000066 CL:0000451 ! occurs in dendritic cell
relationship: BFO:0000066 CL:0000451 ! occurs in dendritic cell
relationship: never_in_taxon NCBITaxon:4895
[Term]
id: GO:0002469
name: myeloid dendritic cell antigen processing and presentation
def: "The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0002468 ! dendritic cell antigen processing and presentation
intersection_of: GO:0019882 ! antigen processing and presentation
intersection_of: BFO:0000066 CL:0000782 ! occurs in myeloid dendritic cell
relationship: BFO:0000066 CL:0000782 ! occurs in myeloid dendritic cell
relationship: never_in_taxon NCBITaxon:4895
[Term]
id: GO:0002471
name: monocyte antigen processing and presentation
def: "The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11200054]
is_a: GO:0019882 ! antigen processing and presentation
intersection_of: GO:0019882 ! antigen processing and presentation
intersection_of: BFO:0000066 CL:0000576 ! occurs in monocyte
relationship: BFO:0000066 CL:0000576 ! occurs in monocyte
relationship: never_in_taxon NCBITaxon:4895
[Term]
id: GO:0002472
name: macrophage antigen processing and presentation
def: "The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0019882 ! antigen processing and presentation
intersection_of: GO:0019882 ! antigen processing and presentation
intersection_of: BFO:0000066 CL:0000235 ! occurs in macrophage
relationship: BFO:0000066 CL:0000235 ! occurs in macrophage
relationship: never_in_taxon NCBITaxon:4895
[Term]
id: GO:0002483
name: antigen processing and presentation of endogenous peptide antigen
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell." [GOC:add, ISBN:0781735149]
synonym: "endogenous peptide antigen processing and presentation" EXACT []
is_a: GO:0019883 ! antigen processing and presentation of endogenous antigen
is_a: GO:0048002 ! antigen processing and presentation of peptide antigen
relationship: never_in_taxon NCBITaxon:4895
[Term]
id: GO:0002491
name: antigen processing and presentation of endogenous peptide antigen via MHC class II
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, PMID:15531770, PMID:16181338]
synonym: "endogenous peptide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen
is_a: GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II
relationship: never_in_taxon NCBITaxon:4895
[Term]
id: GO:0002495
name: antigen processing and presentation of peptide antigen via MHC class II
def: "The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, ISBN:0781735149, PMID:15531770, PMID:15771591]
synonym: "peptide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
is_a: GO:0048002 ! antigen processing and presentation of peptide antigen
relationship: never_in_taxon NCBITaxon:4895
[Term]
id: GO:0002496
name: proteolysis associated with antigen processing and presentation
def: "The hydrolysis of a peptide bond or bonds within a protein contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591]
is_a: GO:0051603 ! proteolysis involved in protein catabolic process
intersection_of: GO:0006508 ! proteolysis
intersection_of: part_of GO:0048002 ! antigen processing and presentation of peptide antigen
relationship: never_in_taxon NCBITaxon:4895
relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen
[Term]
id: GO:0002500
name: proteolysis within lysosome associated with antigen processing and presentation
def: "The hydrolysis of a peptide bond or bonds within a protein by lysosomal resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15771591]
synonym: "lysosomal proteolysis associated with antigen processing and presentation" EXACT []
is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation
intersection_of: GO:0002496 ! proteolysis associated with antigen processing and presentation
intersection_of: BFO:0000066 GO:0005764 ! occurs in lysosome
relationship: BFO:0000066 GO:0005764 ! occurs in lysosome
relationship: never_in_taxon NCBITaxon:4895
[Term]
id: GO:0002504
name: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
def: "The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15531770, PMID:15771591, PMID:16153240]
synonym: "peptide or polysaccharide antigen processing and presentation of via MHC class II" EXACT []
is_a: GO:0019882 ! antigen processing and presentation
relationship: never_in_taxon NCBITaxon:4895
[Term]
id: GO:0002520
name: immune system development
def: "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph]
subset: goslim_drosophila
is_a: GO:0002376 ! immune system process
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002405 ! results in development of immune system
relationship: in_taxon NCBITaxon:131567 ! cellular organism
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4895
relationship: never_in_taxon NCBITaxon:4932
relationship: RO:0002296 UBERON:0002405 ! results in development of immune system
[Term]
id: GO:0002521
name: leukocyte differentiation
def: "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:add, PMID:16551264]
synonym: "immune cell differentiation" EXACT []
synonym: "leucocyte differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000738 ! results in acquisition of features of leukocyte
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0030097 ! hemopoiesis
relationship: RO:0002315 CL:0000738 ! results in acquisition of features of leukocyte
[Term]
id: GO:0002522
name: leukocyte migration involved in immune response
def: "The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
synonym: "immune cell migration during immune response" EXACT []
synonym: "immune cell trafficking during immune response" EXACT []
synonym: "leucocyte migration during immune response" EXACT []
synonym: "leucocyte trafficking during immune response" EXACT []
synonym: "leukocyte trafficking during immune response" EXACT []
is_a: GO:0002252 ! immune effector process
is_a: GO:0050900 ! leukocyte migration
intersection_of: GO:0050900 ! leukocyte migration
intersection_of: part_of GO:0006955 ! immune response
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0006955 ! immune response
[Term]
id: GO:0002523
name: leukocyte migration involved in inflammatory response
def: "The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
synonym: "immune cell migration during inflammatory response" RELATED []
synonym: "immune cell trafficking during inflammatory response" RELATED []
synonym: "leucocyte migration during inflammatory response" RELATED []
synonym: "leucocyte trafficking during inflammatory response" RELATED []
synonym: "leukocyte migration during inflammatory response" RELATED [GOC:dph]
synonym: "leukocyte trafficking during inflammatory response" RELATED []
is_a: GO:0050900 ! leukocyte migration
intersection_of: GO:0050900 ! leukocyte migration
intersection_of: part_of GO:0006954 ! inflammatory response
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0006954 ! inflammatory response
[Term]
id: GO:0002532
name: production of molecular mediator involved in inflammatory response
def: "The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149]
synonym: "production of cellular mediator of acute inflammation" RELATED []
synonym: "production of molecular mediator involved in acute inflammatory response" BROAD []
is_a: GO:0032501 ! multicellular organismal process
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0006954 ! inflammatory response
[Term]
id: GO:0002534
name: cytokine production involved in inflammatory response
def: "The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
subset: gocheck_do_not_annotate
synonym: "cytokine production involved in acute inflammatory response" BROAD []
is_a: GO:0001816 ! cytokine production
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response
intersection_of: GO:0001816 ! cytokine production
intersection_of: part_of GO:0006954 ! inflammatory response
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0006954 ! inflammatory response
[Term]
id: GO:0002548
name: monocyte chemotaxis
def: "The movement of a monocyte in response to an external stimulus." [GOC:add, PMID:11696603, PMID:15173832]
is_a: GO:0030595 ! leukocyte chemotaxis
is_a: GO:0071674 ! mononuclear cell migration
is_a: GO:0097529 ! myeloid leukocyte migration
intersection_of: GO:0006935 ! chemotaxis
intersection_of: RO:0002565 CL:0000576 ! results in movement of monocyte
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002565 CL:0000576 ! results in movement of monocyte
[Term]
id: GO:0002554
name: serotonin secretion by platelet
def: "The regulated release of serotonin by a platelet or group of platelets." [GOC:add, ISBN:0781735149]
synonym: "serotonin release by platelet" RELATED [GOC:tb]
is_a: GO:0002442 ! serotonin secretion involved in inflammatory response
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0140029 ! exocytic process
intersection_of: GO:0001820 ! serotonin secretion
intersection_of: RO:0002608 CL:0000233 ! process has causal agent platelet
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0002576 ! platelet degranulation
relationship: RO:0002608 CL:0000233 ! process has causal agent platelet
[Term]
id: GO:0002555
name: histamine secretion by platelet
def: "The regulated release of histamine by a platelet or group of platelets." [GOC:add, PMID:9117517]
is_a: GO:0002441 ! histamine secretion involved in inflammatory response
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0140029 ! exocytic process
intersection_of: GO:0001821 ! histamine secretion
intersection_of: RO:0002608 CL:0000233 ! process has causal agent platelet
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0002576 ! platelet degranulation
relationship: RO:0002608 CL:0000233 ! process has causal agent platelet
[Term]
id: GO:0002562
name: somatic diversification of immune receptors via germline recombination within a single locus
def: "The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus." [GOC:add, ISBN:0781735149, PMID:16102575, PMID:16166509]
is_a: GO:0002200 ! somatic diversification of immune receptors
is_a: GO:0016444 ! somatic cell DNA recombination
relationship: in_taxon NCBITaxon:131567 ! cellular organism
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4751 ! Fungi
[Term]
id: GO:0002566
name: somatic diversification of immune receptors via somatic mutation
def: "The process in which immune receptor genes are diversified through somatic mutation." [ISBN:0781735149, PMID:16102575]
is_a: GO:0002200 ! somatic diversification of immune receptors
relationship: in_taxon NCBITaxon:131567 ! cellular organism
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4895
relationship: never_in_taxon NCBITaxon:4932
[Term]
id: GO:0002572
name: pro-T cell differentiation
def: "The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed." [GOC:add, ISBN:0781735149]
synonym: "pro-T lymphocyte differentiation" EXACT []
is_a: GO:0002320 ! lymphoid progenitor cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000827 ! results in acquisition of features of pro-T cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0030217 ! T cell differentiation
relationship: RO:0002315 CL:0000827 ! results in acquisition of features of pro-T cell
[Term]
id: GO:0002573
name: myeloid leukocyte differentiation
def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage." [GOC:add, PMID:16551251]
synonym: "myeloid leucocyte differentiation" EXACT []
is_a: GO:0002521 ! leukocyte differentiation
is_a: GO:0030099 ! myeloid cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000766 ! results in acquisition of features of myeloid leukocyte
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002315 CL:0000766 ! results in acquisition of features of myeloid leukocyte
[Term]
id: GO:0002574
name: thrombocyte differentiation
def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis." [GOC:add]
comment: Note that platelets are the non-nucleated mammalian functional equivalent of the nucleated thrombocytes of non-mammalian vertebrates and are sometimes also referred to as thrombocytes. Platelet formation in mammals is covered by the biological_process term platelet formation ; GO:0030220.
is_a: GO:0030099 ! myeloid cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000762 ! results in acquisition of features of nucleated thrombocyte
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002315 CL:0000762 ! results in acquisition of features of nucleated thrombocyte
[Term]
id: GO:0002576
name: platelet degranulation
def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet." [GOC:add]
synonym: "platelet exocytosis" EXACT []
xref: Reactome:R-HSA-114608 "Platelet degranulation"
is_a: GO:0045055 ! regulated exocytosis
is_a: GO:0051649 ! establishment of localization in cell
intersection_of: GO:0045055 ! regulated exocytosis
intersection_of: BFO:0000066 CL:0000233 ! occurs in platelet
relationship: BFO:0000066 CL:0000233 ! occurs in platelet
relationship: in_taxon NCBITaxon:131567 ! cellular organism
[Term]
id: GO:0002577
name: regulation of antigen processing and presentation
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation." [GOC:add]
is_a: GO:0002682 ! regulation of immune system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0019882 ! regulates (processual) antigen processing and presentation
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002211 GO:0019882 ! regulates (processual) antigen processing and presentation
[Term]
id: GO:0002578
name: negative regulation of antigen processing and presentation
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation." [GOC:add]
synonym: "down regulation of antigen processing and presentation" EXACT []
synonym: "down-regulation of antigen processing and presentation" EXACT []
synonym: "downregulation of antigen processing and presentation" EXACT []
synonym: "inhibition of antigen processing and presentation" NARROW []
is_a: GO:0002577 ! regulation of antigen processing and presentation
is_a: GO:0002683 ! negative regulation of immune system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0019882 ! negatively regulates antigen processing and presentation
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002212 GO:0019882 ! negatively regulates antigen processing and presentation
[Term]
id: GO:0002579
name: positive regulation of antigen processing and presentation
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation." [GOC:add]
synonym: "activation of antigen processing and presentation" NARROW []
synonym: "stimulation of antigen processing and presentation" NARROW []
synonym: "up regulation of antigen processing and presentation" EXACT []
synonym: "up-regulation of antigen processing and presentation" EXACT []
synonym: "upregulation of antigen processing and presentation" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
is_a: GO:0002684 ! positive regulation of immune system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0019882 ! positively regulates antigen processing and presentation
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002213 GO:0019882 ! positively regulates antigen processing and presentation
[Term]
id: GO:0002580
name: regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add]
synonym: "regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002504 ! regulates (processual) antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002211 GO:0002504 ! regulates (processual) antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
[Term]
id: GO:0002581
name: negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add]
synonym: "down regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "down-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "downregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "inhibition of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW []
synonym: "negative regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002504 ! negatively regulates antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002212 GO:0002504 ! negatively regulates antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
[Term]
id: GO:0002582
name: positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add]
synonym: "activation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW []
synonym: "positive regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT []
synonym: "stimulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW []
synonym: "up regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "up-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "upregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002504 ! positively regulates antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002213 GO:0002504 ! positively regulates antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
[Term]
id: GO:0002583
name: regulation of antigen processing and presentation of peptide antigen
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add]
synonym: "regulation of peptide antigen processing and presentation" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048002 ! regulates (processual) antigen processing and presentation of peptide antigen
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002211 GO:0048002 ! regulates (processual) antigen processing and presentation of peptide antigen
[Term]
id: GO:0002584
name: negative regulation of antigen processing and presentation of peptide antigen
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add]
synonym: "down regulation of antigen processing and presentation of peptide antigen" EXACT []
synonym: "down-regulation of antigen processing and presentation of peptide antigen" EXACT []
synonym: "downregulation of antigen processing and presentation of peptide antigen" EXACT []
synonym: "inhibition of antigen processing and presentation of peptide antigen" NARROW []
synonym: "negative regulation of peptide antigen processing and presentation" EXACT []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0048002 ! negatively regulates antigen processing and presentation of peptide antigen
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002212 GO:0048002 ! negatively regulates antigen processing and presentation of peptide antigen
[Term]
id: GO:0002585
name: positive regulation of antigen processing and presentation of peptide antigen
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add]
synonym: "activation of antigen processing and presentation of peptide antigen" NARROW []
synonym: "positive regulation of peptide antigen processing and presentation" EXACT []
synonym: "stimulation of antigen processing and presentation of peptide antigen" NARROW []
synonym: "up regulation of antigen processing and presentation of peptide antigen" EXACT []
synonym: "up-regulation of antigen processing and presentation of peptide antigen" EXACT []
synonym: "upregulation of antigen processing and presentation of peptide antigen" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0048002 ! positively regulates antigen processing and presentation of peptide antigen
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002213 GO:0048002 ! positively regulates antigen processing and presentation of peptide antigen
[Term]
id: GO:0002586
name: regulation of antigen processing and presentation of peptide antigen via MHC class II
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add]
synonym: "regulation of peptide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002495 ! regulates (processual) antigen processing and presentation of peptide antigen via MHC class II
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002211 GO:0002495 ! regulates (processual) antigen processing and presentation of peptide antigen via MHC class II
[Term]
id: GO:0002587
name: negative regulation of antigen processing and presentation of peptide antigen via MHC class II
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add]
synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT []
synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT []
synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT []
synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class II" NARROW []
synonym: "negative regulation of peptide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002581 ! negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002586 ! regulation of antigen processing and presentation of peptide antigen via MHC class II
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002495 ! negatively regulates antigen processing and presentation of peptide antigen via MHC class II
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002212 GO:0002495 ! negatively regulates antigen processing and presentation of peptide antigen via MHC class II
[Term]
id: GO:0002588
name: positive regulation of antigen processing and presentation of peptide antigen via MHC class II
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add]
synonym: "activation of antigen processing and presentation of peptide antigen via MHC class II" NARROW []
synonym: "positive regulation of peptide antigen processing and presentation via MHC class II" EXACT []
synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class II" NARROW []
synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT []
synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT []
synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT []
is_a: GO:0002582 ! positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002586 ! regulation of antigen processing and presentation of peptide antigen via MHC class II
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002495 ! positively regulates antigen processing and presentation of peptide antigen via MHC class II
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002213 GO:0002495 ! positively regulates antigen processing and presentation of peptide antigen via MHC class II
[Term]
id: GO:0002604
name: regulation of dendritic cell antigen processing and presentation
def: "Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add]
is_a: GO:0002577 ! regulation of antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002468 ! regulates (processual) dendritic cell antigen processing and presentation
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002211 GO:0002468 ! regulates (processual) dendritic cell antigen processing and presentation
[Term]
id: GO:0002605
name: negative regulation of dendritic cell antigen processing and presentation
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "down-regulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "downregulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "inhibition of dendritic cell antigen processing and presentation" NARROW []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002468 ! negatively regulates dendritic cell antigen processing and presentation
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002212 GO:0002468 ! negatively regulates dendritic cell antigen processing and presentation
[Term]
id: GO:0002606
name: positive regulation of dendritic cell antigen processing and presentation
def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add]
synonym: "activation of dendritic cell antigen processing and presentation" NARROW []
synonym: "stimulation of dendritic cell antigen processing and presentation" NARROW []
synonym: "up regulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "up-regulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "upregulation of dendritic cell antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002468 ! positively regulates dendritic cell antigen processing and presentation
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002213 GO:0002468 ! positively regulates dendritic cell antigen processing and presentation
[Term]
id: GO:0002607
name: regulation of myeloid dendritic cell antigen processing and presentation
def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add]
is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002469 ! regulates (processual) myeloid dendritic cell antigen processing and presentation
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002211 GO:0002469 ! regulates (processual) myeloid dendritic cell antigen processing and presentation
[Term]
id: GO:0002608
name: negative regulation of myeloid dendritic cell antigen processing and presentation
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of myeloid dendritic cell antigen processing and presentation" EXACT []
synonym: "down-regulation of myeloid dendritic cell antigen processing and presentation" EXACT []
synonym: "downregulation of myeloid dendritic cell antigen processing and presentation" EXACT []
synonym: "inhibition of myeloid dendritic cell antigen processing and presentation" NARROW []
is_a: GO:0002605 ! negative regulation of dendritic cell antigen processing and presentation
is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002469 ! negatively regulates myeloid dendritic cell antigen processing and presentation
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002212 GO:0002469 ! negatively regulates myeloid dendritic cell antigen processing and presentation
[Term]
id: GO:0002609
name: positive regulation of myeloid dendritic cell antigen processing and presentation
def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add]
synonym: "activation of myeloid dendritic cell antigen processing and presentation" NARROW []
synonym: "stimulation of myeloid dendritic cell antigen processing and presentation" NARROW []
synonym: "up regulation of myeloid dendritic cell antigen processing and presentation" EXACT []
synonym: "up-regulation of myeloid dendritic cell antigen processing and presentation" EXACT []
synonym: "upregulation of myeloid dendritic cell antigen processing and presentation" EXACT []
is_a: GO:0002606 ! positive regulation of dendritic cell antigen processing and presentation
is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002469 ! positively regulates myeloid dendritic cell antigen processing and presentation
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002213 GO:0002469 ! positively regulates myeloid dendritic cell antigen processing and presentation
[Term]
id: GO:0002613
name: regulation of monocyte antigen processing and presentation
def: "Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add]
is_a: GO:0002577 ! regulation of antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002471 ! regulates (processual) monocyte antigen processing and presentation
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002211 GO:0002471 ! regulates (processual) monocyte antigen processing and presentation
[Term]
id: GO:0002614
name: negative regulation of monocyte antigen processing and presentation
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add]
synonym: "down regulation of monocyte antigen processing and presentation" EXACT []
synonym: "down-regulation of monocyte antigen processing and presentation" EXACT []
synonym: "downregulation of monocyte antigen processing and presentation" EXACT []
synonym: "inhibition of monocyte antigen processing and presentation" NARROW []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002471 ! negatively regulates monocyte antigen processing and presentation
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002212 GO:0002471 ! negatively regulates monocyte antigen processing and presentation
[Term]
id: GO:0002615
name: positive regulation of monocyte antigen processing and presentation
def: "Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add]
synonym: "activation of monocyte antigen processing and presentation" NARROW []
synonym: "stimulation of monocyte antigen processing and presentation" NARROW []
synonym: "up regulation of monocyte antigen processing and presentation" EXACT []
synonym: "up-regulation of monocyte antigen processing and presentation" EXACT []
synonym: "upregulation of monocyte antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002471 ! positively regulates monocyte antigen processing and presentation
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002213 GO:0002471 ! positively regulates monocyte antigen processing and presentation
[Term]
id: GO:0002616
name: regulation of macrophage antigen processing and presentation
def: "Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add]
is_a: GO:0002577 ! regulation of antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002472 ! regulates (processual) macrophage antigen processing and presentation
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002211 GO:0002472 ! regulates (processual) macrophage antigen processing and presentation
[Term]
id: GO:0002617
name: negative regulation of macrophage antigen processing and presentation
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add]
synonym: "down regulation of macrophage antigen processing and presentation" EXACT []
synonym: "down-regulation of macrophage antigen processing and presentation" EXACT []
synonym: "downregulation of macrophage antigen processing and presentation" EXACT []
synonym: "inhibition of macrophage antigen processing and presentation" NARROW []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002472 ! negatively regulates macrophage antigen processing and presentation
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002212 GO:0002472 ! negatively regulates macrophage antigen processing and presentation
[Term]
id: GO:0002618
name: positive regulation of macrophage antigen processing and presentation
def: "Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add]
synonym: "activation of macrophage antigen processing and presentation" NARROW []
synonym: "stimulation of macrophage antigen processing and presentation" NARROW []
synonym: "up regulation of macrophage antigen processing and presentation" EXACT []
synonym: "up-regulation of macrophage antigen processing and presentation" EXACT []
synonym: "upregulation of macrophage antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002472 ! positively regulates macrophage antigen processing and presentation
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002213 GO:0002472 ! positively regulates macrophage antigen processing and presentation
[Term]
id: GO:0002622
name: regulation of B cell antigen processing and presentation
def: "Any process that modulates the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add]
synonym: "regulation of B lymphocyte antigen processing and presentation" EXACT []
synonym: "regulation of B-cell antigen processing and presentation" EXACT []
synonym: "regulation of B-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
is_a: GO:0002712 ! regulation of B cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002450 ! regulates (processual) B cell antigen processing and presentation
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: RO:0002211 GO:0002450 ! regulates (processual) B cell antigen processing and presentation
[Term]
id: GO:0002623
name: negative regulation of B cell antigen processing and presentation
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of B cell antigen processing and presentation" EXACT []
synonym: "down-regulation of B cell antigen processing and presentation" EXACT []
synonym: "downregulation of B cell antigen processing and presentation" EXACT []
synonym: "inhibition of B cell antigen processing and presentation" NARROW []
synonym: "negative regulation of B lymphocyte antigen processing and presentation" EXACT []
synonym: "negative regulation of B-cell antigen processing and presentation" EXACT []
synonym: "negative regulation of B-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002622 ! regulation of B cell antigen processing and presentation
is_a: GO:0002713 ! negative regulation of B cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002450 ! negatively regulates B cell antigen processing and presentation
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: RO:0002212 GO:0002450 ! negatively regulates B cell antigen processing and presentation
[Term]
id: GO:0002624
name: positive regulation of B cell antigen processing and presentation
def: "Any process that activates or increases the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add]
synonym: "activation of B cell antigen processing and presentation" NARROW []
synonym: "positive regulation of B lymphocyte antigen processing and presentation" EXACT []
synonym: "positive regulation of B-cell antigen processing and presentation" EXACT []
synonym: "positive regulation of B-lymphocyte antigen processing and presentation" EXACT []
synonym: "stimulation of B cell antigen processing and presentation" NARROW []
synonym: "up regulation of B cell antigen processing and presentation" EXACT []
synonym: "up-regulation of B cell antigen processing and presentation" EXACT []
synonym: "upregulation of B cell antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002622 ! regulation of B cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002450 ! positively regulates B cell antigen processing and presentation
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: RO:0002213 GO:0002450 ! positively regulates B cell antigen processing and presentation
[Term]
id: GO:0002625
name: regulation of T cell antigen processing and presentation
def: "Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add]
synonym: "regulation of T lymphocyte antigen processing and presentation" EXACT []
synonym: "regulation of T-cell antigen processing and presentation" EXACT []
synonym: "regulation of T-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
is_a: GO:0002709 ! regulation of T cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002457 ! regulates (processual) T cell antigen processing and presentation
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: RO:0002211 GO:0002457 ! regulates (processual) T cell antigen processing and presentation
[Term]
id: GO:0002626
name: negative regulation of T cell antigen processing and presentation
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of T cell antigen processing and presentation" EXACT []
synonym: "down-regulation of T cell antigen processing and presentation" EXACT []
synonym: "downregulation of T cell antigen processing and presentation" EXACT []
synonym: "inhibition of T cell antigen processing and presentation" NARROW []
synonym: "negative regulation of T lymphocyte antigen processing and presentation" EXACT []
synonym: "negative regulation of T-cell antigen processing and presentation" EXACT []
synonym: "negative regulation of T-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002625 ! regulation of T cell antigen processing and presentation
is_a: GO:0002710 ! negative regulation of T cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002457 ! negatively regulates T cell antigen processing and presentation
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: RO:0002212 GO:0002457 ! negatively regulates T cell antigen processing and presentation
[Term]
id: GO:0002627
name: positive regulation of T cell antigen processing and presentation
def: "Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add]
synonym: "activation of T cell antigen processing and presentation" NARROW []
synonym: "positive regulation of T lymphocyte antigen processing and presentation" EXACT []
synonym: "positive regulation of T-cell antigen processing and presentation" EXACT []
synonym: "positive regulation of T-lymphocyte antigen processing and presentation" EXACT []
synonym: "stimulation of T cell antigen processing and presentation" NARROW []
synonym: "up regulation of T cell antigen processing and presentation" EXACT []
synonym: "up-regulation of T cell antigen processing and presentation" EXACT []
synonym: "upregulation of T cell antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002625 ! regulation of T cell antigen processing and presentation
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002457 ! positively regulates T cell antigen processing and presentation
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: RO:0002213 GO:0002457 ! positively regulates T cell antigen processing and presentation
[Term]
id: GO:0002628
name: regulation of proteolysis associated with antigen processing and presentation
def: "Any process that modulates the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add]
is_a: GO:1903050 ! regulation of proteolysis involved in protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002496 ! regulates (processual) proteolysis associated with antigen processing and presentation
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002211 GO:0002496 ! regulates (processual) proteolysis associated with antigen processing and presentation
[Term]
id: GO:0002629
name: negative regulation of proteolysis associated with antigen processing and presentation
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add]
synonym: "down regulation of proteolysis associated with antigen processing and presentation" EXACT []
synonym: "down-regulation of proteolysis associated with antigen processing and presentation" EXACT []
synonym: "downregulation of proteolysis associated with antigen processing and presentation" EXACT []
synonym: "inhibition of proteolysis associated with antigen processing and presentation" NARROW []
is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002628 ! regulation of proteolysis associated with antigen processing and presentation
is_a: GO:0042177 ! negative regulation of protein catabolic process
is_a: GO:1903051 ! negative regulation of proteolysis involved in protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002496 ! negatively regulates proteolysis associated with antigen processing and presentation
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002212 GO:0002496 ! negatively regulates proteolysis associated with antigen processing and presentation
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/29024" xsd:anyURI
[Term]
id: GO:0002630
name: positive regulation of proteolysis associated with antigen processing and presentation
def: "Any process that activates or increases the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add]
synonym: "activation of proteolysis associated with antigen processing and presentation" NARROW []
synonym: "stimulation of proteolysis associated with antigen processing and presentation" NARROW []
synonym: "up regulation of proteolysis associated with antigen processing and presentation" EXACT []
synonym: "up-regulation of proteolysis associated with antigen processing and presentation" EXACT []
synonym: "upregulation of proteolysis associated with antigen processing and presentation" EXACT []
is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002628 ! regulation of proteolysis associated with antigen processing and presentation
is_a: GO:0045732 ! positive regulation of protein catabolic process
is_a: GO:1903052 ! positive regulation of proteolysis involved in protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002496 ! positively regulates proteolysis associated with antigen processing and presentation
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002213 GO:0002496 ! positively regulates proteolysis associated with antigen processing and presentation
[Term]
id: GO:0002634
name: regulation of germinal center formation
def: "Any process that modulates the frequency, rate, or extent of germinal center formation." [GOC:add]
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002467 ! regulates (processual) germinal center formation
relationship: in_taxon NCBITaxon:40674 ! Mammalia
relationship: RO:0002211 GO:0002467 ! regulates (processual) germinal center formation
[Term]
id: GO:0002635
name: negative regulation of germinal center formation
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of germinal center formation." [GOC:add]
synonym: "down regulation of germinal center formation" EXACT []
synonym: "down-regulation of germinal center formation" EXACT []
synonym: "downregulation of germinal center formation" EXACT []
synonym: "inhibition of germinal center formation" NARROW []
is_a: GO:0002634 ! regulation of germinal center formation
is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0051093 ! negative regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002467 ! negatively regulates germinal center formation
relationship: in_taxon NCBITaxon:40674 ! Mammalia
relationship: RO:0002212 GO:0002467 ! negatively regulates germinal center formation
[Term]
id: GO:0002636
name: positive regulation of germinal center formation
def: "Any process that activates or increases the frequency, rate, or extent of germinal center formation." [GOC:add]
synonym: "activation of germinal center formation" NARROW []
synonym: "stimulation of germinal center formation" NARROW []
synonym: "up regulation of germinal center formation" EXACT []
synonym: "up-regulation of germinal center formation" EXACT []
synonym: "upregulation of germinal center formation" EXACT []
is_a: GO:0002634 ! regulation of germinal center formation
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0051094 ! positive regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002467 ! positively regulates germinal center formation
relationship: in_taxon NCBITaxon:40674 ! Mammalia
relationship: RO:0002213 GO:0002467 ! positively regulates germinal center formation
[Term]
id: GO:0002637
name: regulation of immunoglobulin production
alt_id: GO:0002640
alt_id: GO:0051023
def: "Any process that modulates the frequency, rate, or extent of immunoglobulin production." [GOC:add]
synonym: "regulation of antibody production" EXACT []
synonym: "regulation of immunoglobulin biosynthetic process" NARROW []
synonym: "regulation of immunoglobulin secretion" NARROW []
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002377 ! regulates (processual) immunoglobulin production
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002211 GO:0002377 ! regulates (processual) immunoglobulin production
[Term]
id: GO:0002638
name: negative regulation of immunoglobulin production
alt_id: GO:0002641
alt_id: GO:0051025
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production." [GOC:add]
synonym: "down regulation of immunoglobulin production" EXACT []
synonym: "down-regulation of immunoglobulin production" EXACT []
synonym: "downregulation of immunoglobulin production" EXACT []
synonym: "inhibition of immunoglobulin production" NARROW []
synonym: "negative regulation of immunoglobulin biosynthetic process" NARROW []
synonym: "negative regulation of immunoglobulin secretion" NARROW []
is_a: GO:0002637 ! regulation of immunoglobulin production
is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002377 ! negatively regulates immunoglobulin production
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002212 GO:0002377 ! negatively regulates immunoglobulin production
[Term]
id: GO:0002639
name: positive regulation of immunoglobulin production
alt_id: GO:0002642
alt_id: GO:0051024
def: "Any process that activates or increases the frequency, rate, or extent of immunoglobulin production." [GOC:add]
synonym: "activation of immunoglobulin production" NARROW []
synonym: "positive regulation of immunoglobulin biosynthetic process" NARROW []
synonym: "positive regulation of immunoglobulin secretion" NARROW []
synonym: "stimulation of immunoglobulin production" NARROW []
synonym: "up regulation of immunoglobulin production" EXACT []
synonym: "up-regulation of immunoglobulin production" EXACT []
synonym: "upregulation of immunoglobulin production" EXACT []
is_a: GO:0002637 ! regulation of immunoglobulin production
is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002377 ! positively regulates immunoglobulin production
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002213 GO:0002377 ! positively regulates immunoglobulin production
[Term]
id: GO:0002682
name: regulation of immune system process
def: "Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002376 ! regulates (processual) immune system process
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002211 GO:0002376 ! regulates (processual) immune system process
[Term]
id: GO:0002683
name: negative regulation of immune system process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add]
synonym: "down regulation of immune system process" EXACT []
synonym: "down-regulation of immune system process" EXACT []
synonym: "downregulation of immune system process" EXACT []
synonym: "inhibition of immune system process" NARROW []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0048519 ! negative regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002376 ! negatively regulates immune system process
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002212 GO:0002376 ! negatively regulates immune system process
[Term]
id: GO:0002684
name: positive regulation of immune system process
def: "Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add]
synonym: "activation of immune system process" NARROW []
synonym: "stimulation of immune system process" NARROW []
synonym: "up regulation of immune system process" EXACT []
synonym: "up-regulation of immune system process" EXACT []
synonym: "upregulation of immune system process" EXACT []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0048518 ! positive regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002376 ! positively regulates immune system process
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002213 GO:0002376 ! positively regulates immune system process
[Term]
id: GO:0002685
name: regulation of leukocyte migration
def: "Any process that modulates the frequency, rate, or extent of leukocyte migration." [GOC:add]
synonym: "regulation of immune cell migration" EXACT []
synonym: "regulation of leucocyte migration" EXACT []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0050900 ! regulates (processual) leukocyte migration
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002211 GO:0050900 ! regulates (processual) leukocyte migration
[Term]
id: GO:0002686
name: negative regulation of leukocyte migration
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration." [GOC:add]
synonym: "down regulation of leukocyte migration" EXACT []
synonym: "down-regulation of leukocyte migration" EXACT []
synonym: "downregulation of leukocyte migration" EXACT []
synonym: "inhibition of leukocyte migration" NARROW []
synonym: "negative regulation of immune cell migration" EXACT []
synonym: "negative regulation of leucocyte migration" EXACT []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0002685 ! regulation of leukocyte migration
is_a: GO:0030336 ! negative regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0050900 ! negatively regulates leukocyte migration
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002212 GO:0050900 ! negatively regulates leukocyte migration
[Term]
id: GO:0002687
name: positive regulation of leukocyte migration
def: "Any process that activates or increases the frequency, rate, or extent of leukocyte migration." [GOC:add]
synonym: "activation of leukocyte migration" NARROW []
synonym: "positive regulation of immune cell migration" EXACT []
synonym: "positive regulation of leucocyte migration" EXACT []
synonym: "stimulation of leukocyte migration" NARROW []
synonym: "up regulation of leukocyte migration" EXACT []
synonym: "up-regulation of leukocyte migration" EXACT []
synonym: "upregulation of leukocyte migration" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0002685 ! regulation of leukocyte migration
is_a: GO:0030335 ! positive regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0050900 ! positively regulates leukocyte migration
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002213 GO:0050900 ! positively regulates leukocyte migration
[Term]
id: GO:0002688
name: regulation of leukocyte chemotaxis
def: "Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add]
synonym: "regulation of immune cell chemotaxis" EXACT []
synonym: "regulation of leucocyte chemotaxis" EXACT []
is_a: GO:0002685 ! regulation of leukocyte migration
is_a: GO:0050920 ! regulation of chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030595 ! regulates (processual) leukocyte chemotaxis
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002211 GO:0030595 ! regulates (processual) leukocyte chemotaxis
[Term]
id: GO:0002689
name: negative regulation of leukocyte chemotaxis
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add]
synonym: "down regulation of leukocyte chemotaxis" EXACT []
synonym: "down-regulation of leukocyte chemotaxis" EXACT []
synonym: "downregulation of leukocyte chemotaxis" EXACT []
synonym: "inhibition of leukocyte chemotaxis" NARROW []
synonym: "negative regulation of immune cell chemotaxis" EXACT []
synonym: "negative regulation of leucocyte chemotaxis" EXACT []
is_a: GO:0002686 ! negative regulation of leukocyte migration
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
is_a: GO:0050922 ! negative regulation of chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0030595 ! negatively regulates leukocyte chemotaxis
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002212 GO:0030595 ! negatively regulates leukocyte chemotaxis
[Term]
id: GO:0002690
name: positive regulation of leukocyte chemotaxis
def: "Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add]
synonym: "activation of leukocyte chemotaxis" NARROW []
synonym: "positive regulation of immune cell chemotaxis" EXACT []
synonym: "positive regulation of leucocyte chemotaxis" EXACT []
synonym: "stimulation of leukocyte chemotaxis" NARROW []
synonym: "up regulation of leukocyte chemotaxis" EXACT []
synonym: "up-regulation of leukocyte chemotaxis" EXACT []
synonym: "upregulation of leukocyte chemotaxis" EXACT []
is_a: GO:0002687 ! positive regulation of leukocyte migration
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
is_a: GO:0050921 ! positive regulation of chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0030595 ! positively regulates leukocyte chemotaxis
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002213 GO:0030595 ! positively regulates leukocyte chemotaxis
[Term]
id: GO:0002694
name: regulation of leukocyte activation
def: "Any process that modulates the frequency, rate, or extent of leukocyte activation." [GOC:add]
synonym: "regulation of immune cell activation" EXACT []
synonym: "regulation of leucocyte activation" EXACT []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0050865 ! regulation of cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0045321 ! regulates (processual) leukocyte activation
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002211 GO:0045321 ! regulates (processual) leukocyte activation
[Term]
id: GO:0002695
name: negative regulation of leukocyte activation
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation." [GOC:add]
synonym: "down regulation of leukocyte activation" EXACT []
synonym: "down-regulation of leukocyte activation" EXACT []
synonym: "downregulation of leukocyte activation" EXACT []
synonym: "inhibition of leukocyte activation" NARROW []
synonym: "negative regulation of immune cell activation" EXACT []
synonym: "negative regulation of leucocyte activation" EXACT []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0002694 ! regulation of leukocyte activation
is_a: GO:0050866 ! negative regulation of cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0045321 ! negatively regulates leukocyte activation
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002212 GO:0045321 ! negatively regulates leukocyte activation
[Term]
id: GO:0002696
name: positive regulation of leukocyte activation
def: "Any process that activates or increases the frequency, rate, or extent of leukocyte activation." [GOC:add]
synonym: "activation of leukocyte activation" NARROW []
synonym: "positive regulation of immune cell activation" EXACT []
synonym: "positive regulation of leucocyte activation" EXACT []
synonym: "stimulation of leukocyte activation" NARROW []
synonym: "up regulation of leukocyte activation" EXACT []
synonym: "up-regulation of leukocyte activation" EXACT []
synonym: "upregulation of leukocyte activation" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0002694 ! regulation of leukocyte activation
is_a: GO:0050867 ! positive regulation of cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0045321 ! positively regulates leukocyte activation
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002213 GO:0045321 ! positively regulates leukocyte activation
[Term]
id: GO:0002697
name: regulation of immune effector process
def: "Any process that modulates the frequency, rate, or extent of an immune effector process." [GOC:add]
is_a: GO:0002682 ! regulation of immune system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002252 ! regulates (processual) immune effector process
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002211 GO:0002252 ! regulates (processual) immune effector process
[Term]
id: GO:0002698
name: negative regulation of immune effector process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process." [GOC:add]
synonym: "down regulation of immune effector process" EXACT []
synonym: "down-regulation of immune effector process" EXACT []
synonym: "downregulation of immune effector process" EXACT []
synonym: "inhibition of immune effector process" NARROW []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0002697 ! regulation of immune effector process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002252 ! negatively regulates immune effector process
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002212 GO:0002252 ! negatively regulates immune effector process
[Term]
id: GO:0002699
name: positive regulation of immune effector process
def: "Any process that activates or increases the frequency, rate, or extent of an immune effector process." [GOC:add]
synonym: "activation of immune effector process" NARROW []
synonym: "stimulation of immune effector process" NARROW []
synonym: "up regulation of immune effector process" EXACT []
synonym: "up-regulation of immune effector process" EXACT []
synonym: "upregulation of immune effector process" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0002697 ! regulation of immune effector process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002252 ! positively regulates immune effector process
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002213 GO:0002252 ! positively regulates immune effector process
[Term]
id: GO:0002700
name: regulation of production of molecular mediator of immune response
def: "Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add]
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0010468 ! regulation of gene expression
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002440 ! regulates (processual) production of molecular mediator of immune response
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002211 GO:0002440 ! regulates (processual) production of molecular mediator of immune response
[Term]
id: GO:0002701
name: negative regulation of production of molecular mediator of immune response
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add]
synonym: "down regulation of production of molecular mediator of immune response" EXACT []
synonym: "down-regulation of production of molecular mediator of immune response" EXACT []
synonym: "downregulation of production of molecular mediator of immune response" EXACT []
synonym: "inhibition of production of molecular mediator of immune response" NARROW []
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
is_a: GO:0010629 ! negative regulation of gene expression
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002440 ! negatively regulates production of molecular mediator of immune response
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002212 GO:0002440 ! negatively regulates production of molecular mediator of immune response
[Term]
id: GO:0002702
name: positive regulation of production of molecular mediator of immune response
def: "Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add]
synonym: "activation of production of molecular mediator of immune response" NARROW []
synonym: "stimulation of production of molecular mediator of immune response" NARROW []
synonym: "up regulation of production of molecular mediator of immune response" EXACT []
synonym: "up-regulation of production of molecular mediator of immune response" EXACT []
synonym: "upregulation of production of molecular mediator of immune response" EXACT []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
is_a: GO:0010628 ! positive regulation of gene expression
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002440 ! positively regulates production of molecular mediator of immune response
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002213 GO:0002440 ! positively regulates production of molecular mediator of immune response
[Term]
id: GO:0002703
name: regulation of leukocyte mediated immunity
def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add]
synonym: "regulation of immune cell mediated immunity" EXACT []
synonym: "regulation of leucocyte mediated immunity" EXACT []
is_a: GO:0002697 ! regulation of immune effector process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002443 ! regulates (processual) leukocyte mediated immunity
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002211 GO:0002443 ! regulates (processual) leukocyte mediated immunity
[Term]
id: GO:0002704
name: negative regulation of leukocyte mediated immunity
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add]
synonym: "down regulation of leukocyte mediated immunity" EXACT []
synonym: "down-regulation of leukocyte mediated immunity" EXACT []
synonym: "downregulation of leukocyte mediated immunity" EXACT []
synonym: "inhibition of leukocyte mediated immunity" NARROW []
synonym: "negative regulation of immune cell mediated immunity" EXACT []
synonym: "negative regulation of leucocyte mediated immunity" EXACT []
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002443 ! negatively regulates leukocyte mediated immunity
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002212 GO:0002443 ! negatively regulates leukocyte mediated immunity
[Term]
id: GO:0002705
name: positive regulation of leukocyte mediated immunity
def: "Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add]
synonym: "activation of leukocyte mediated immunity" NARROW []
synonym: "positive regulation of immune cell mediated immunity" EXACT []
synonym: "positive regulation of leucocyte mediated immunity" EXACT []
synonym: "stimulation of leukocyte mediated immunity" NARROW []
synonym: "up regulation of leukocyte mediated immunity" EXACT []
synonym: "up-regulation of leukocyte mediated immunity" EXACT []
synonym: "upregulation of leukocyte mediated immunity" EXACT []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002443 ! positively regulates leukocyte mediated immunity
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002213 GO:0002443 ! positively regulates leukocyte mediated immunity
[Term]
id: GO:0002706
name: regulation of lymphocyte mediated immunity
def: "Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add]
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002449 ! regulates (processual) lymphocyte mediated immunity
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002211 GO:0002449 ! regulates (processual) lymphocyte mediated immunity
[Term]
id: GO:0002707
name: negative regulation of lymphocyte mediated immunity
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add]
synonym: "down regulation of lymphocyte mediated immunity" EXACT []
synonym: "down-regulation of lymphocyte mediated immunity" EXACT []
synonym: "downregulation of lymphocyte mediated immunity" EXACT []
synonym: "inhibition of lymphocyte mediated immunity" NARROW []
is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002449 ! negatively regulates lymphocyte mediated immunity
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002212 GO:0002449 ! negatively regulates lymphocyte mediated immunity
[Term]
id: GO:0002708
name: positive regulation of lymphocyte mediated immunity
def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add]
synonym: "activation of lymphocyte mediated immunity" NARROW []
synonym: "stimulation of lymphocyte mediated immunity" NARROW []
synonym: "up regulation of lymphocyte mediated immunity" EXACT []
synonym: "up-regulation of lymphocyte mediated immunity" EXACT []
synonym: "upregulation of lymphocyte mediated immunity" EXACT []
is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002449 ! positively regulates lymphocyte mediated immunity
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002213 GO:0002449 ! positively regulates lymphocyte mediated immunity
[Term]
id: GO:0002709
name: regulation of T cell mediated immunity
def: "Any process that modulates the frequency, rate, or extent of T cell mediated immunity." [GOC:add]
synonym: "regulation of T lymphocyte mediated immunity" EXACT []
synonym: "regulation of T-cell mediated immunity" EXACT []
synonym: "regulation of T-lymphocyte mediated immunity" EXACT []
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002456 ! regulates (processual) T cell mediated immunity
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: RO:0002211 GO:0002456 ! regulates (processual) T cell mediated immunity
[Term]
id: GO:0002710
name: negative regulation of T cell mediated immunity
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity." [GOC:add]
synonym: "down regulation of T cell mediated immunity" EXACT []
synonym: "down-regulation of T cell mediated immunity" EXACT []
synonym: "downregulation of T cell mediated immunity" EXACT []
synonym: "inhibition of T cell mediated immunity" NARROW []
synonym: "negative regulation of T lymphocyte mediated immunity" EXACT []
synonym: "negative regulation of T-cell mediated immunity" EXACT []
synonym: "negative regulation of T-lymphocyte mediated immunity" EXACT []
is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity
is_a: GO:0002709 ! regulation of T cell mediated immunity
is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002456 ! negatively regulates T cell mediated immunity
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: RO:0002212 GO:0002456 ! negatively regulates T cell mediated immunity
[Term]
id: GO:0002711
name: positive regulation of T cell mediated immunity
def: "Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity." [GOC:add]
synonym: "activation of T cell mediated immunity" NARROW []
synonym: "positive regulation of T lymphocyte mediated immunity" EXACT []
synonym: "positive regulation of T-cell mediated immunity" EXACT []
synonym: "positive regulation of T-lymphocyte mediated immunity" EXACT []
synonym: "stimulation of T cell mediated immunity" NARROW []
synonym: "up regulation of T cell mediated immunity" EXACT []
synonym: "up-regulation of T cell mediated immunity" EXACT []
synonym: "upregulation of T cell mediated immunity" EXACT []
is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity
is_a: GO:0002709 ! regulation of T cell mediated immunity
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002456 ! positively regulates T cell mediated immunity
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: RO:0002213 GO:0002456 ! positively regulates T cell mediated immunity
[Term]
id: GO:0002712
name: regulation of B cell mediated immunity
def: "Any process that modulates the frequency, rate, or extent of B cell mediated immunity." [GOC:add]
synonym: "regulation of B lymphocyte mediated immunity" EXACT []
synonym: "regulation of B-cell mediated immunity" EXACT []
synonym: "regulation of B-lymphocyte mediated immunity" EXACT []
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0019724 ! regulates (processual) B cell mediated immunity
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: RO:0002211 GO:0019724 ! regulates (processual) B cell mediated immunity
[Term]
id: GO:0002713
name: negative regulation of B cell mediated immunity
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell mediated immunity." [GOC:add]
synonym: "down regulation of B cell mediated immunity" EXACT []
synonym: "down-regulation of B cell mediated immunity" EXACT []
synonym: "downregulation of B cell mediated immunity" EXACT []
synonym: "inhibition of B cell mediated immunity" NARROW []
synonym: "negative regulation of B lymphocyte mediated immunity" EXACT []
synonym: "negative regulation of B-cell mediated immunity" EXACT []
synonym: "negative regulation of B-lymphocyte mediated immunity" EXACT []
is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity
is_a: GO:0002712 ! regulation of B cell mediated immunity
is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0019724 ! negatively regulates B cell mediated immunity
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: RO:0002212 GO:0019724 ! negatively regulates B cell mediated immunity
[Term]
id: GO:0002714
name: positive regulation of B cell mediated immunity
def: "Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity." [GOC:add]
synonym: "activation of B cell mediated immunity" NARROW []
synonym: "positive regulation of B lymphocyte mediated immunity" EXACT []
synonym: "positive regulation of B-cell mediated immunity" EXACT []
synonym: "positive regulation of B-lymphocyte mediated immunity" EXACT []
synonym: "stimulation of B cell mediated immunity" NARROW []
synonym: "up regulation of B cell mediated immunity" EXACT []
synonym: "up-regulation of B cell mediated immunity" EXACT []
synonym: "upregulation of B cell mediated immunity" EXACT []
is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity
is_a: GO:0002712 ! regulation of B cell mediated immunity
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0019724 ! positively regulates B cell mediated immunity
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: RO:0002213 GO:0019724 ! positively regulates B cell mediated immunity
[Term]
id: GO:0002715
name: regulation of natural killer cell mediated immunity
alt_id: GO:0045845
def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add]
synonym: "regulation of natural killer cell activity" RELATED []
synonym: "regulation of NK cell mediated immunity" EXACT []
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
is_a: GO:0045088 ! regulation of innate immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002228 ! regulates (processual) natural killer cell mediated immunity
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002211 GO:0002228 ! regulates (processual) natural killer cell mediated immunity
[Term]
id: GO:0002716
name: negative regulation of natural killer cell mediated immunity
alt_id: GO:0030102
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add]
synonym: "down regulation of natural killer cell mediated immunity" EXACT []
synonym: "down-regulation of natural killer cell mediated immunity" EXACT []
synonym: "downregulation of natural killer cell mediated immunity" EXACT []
synonym: "inhibition of natural killer cell mediated immunity" NARROW []
synonym: "negative regulation of natural killer cell activity" RELATED []
synonym: "negative regulation of NK cell activity" RELATED []
synonym: "negative regulation of NK cell mediated immunity" EXACT []
is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity
is_a: GO:0002715 ! regulation of natural killer cell mediated immunity
is_a: GO:0045824 ! negative regulation of innate immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002228 ! negatively regulates natural killer cell mediated immunity
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002212 GO:0002228 ! negatively regulates natural killer cell mediated immunity
[Term]
id: GO:0002717
name: positive regulation of natural killer cell mediated immunity
alt_id: GO:0045846
def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add]
synonym: "activation of natural killer cell mediated immunity" NARROW []
synonym: "positive regulation of natural killer cell activity" RELATED []
synonym: "positive regulation of NK cell activity" RELATED []
synonym: "positive regulation of NK cell mediated immunity" EXACT []
synonym: "stimulation of natural killer cell mediated immunity" NARROW []
synonym: "up regulation of natural killer cell mediated immunity" EXACT []
synonym: "up-regulation of natural killer cell mediated immunity" EXACT []
synonym: "upregulation of natural killer cell mediated immunity" EXACT []
is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity
is_a: GO:0002715 ! regulation of natural killer cell mediated immunity
is_a: GO:0045089 ! positive regulation of innate immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002228 ! positively regulates natural killer cell mediated immunity
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002213 GO:0002228 ! positively regulates natural killer cell mediated immunity
[Term]
id: GO:0002718
name: regulation of cytokine production involved in immune response
alt_id: GO:0002739
alt_id: GO:0002742
def: "Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add]
synonym: "regulation of cytokine biosynthetic process involved in immune response" NARROW []
synonym: "regulation of cytokine production during immune response" RELATED [GOC:dph]
synonym: "regulation of cytokine secretion involved in immune response" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002367 ! regulates (processual) cytokine production involved in immune response
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4895
relationship: never_in_taxon NCBITaxon:4932
relationship: RO:0002211 GO:0002367 ! regulates (processual) cytokine production involved in immune response
[Term]
id: GO:0002719
name: negative regulation of cytokine production involved in immune response
alt_id: GO:0002740
alt_id: GO:0002743
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response." [GOC:add]
synonym: "down regulation of cytokine production during immune response" RELATED []
synonym: "down-regulation of cytokine production during immune response" EXACT []
synonym: "downregulation of cytokine production during immune response" RELATED []
synonym: "inhibition of cytokine production during immune response" RELATED []
synonym: "negative regulation of cytokine biosynthetic process involved in immune response" NARROW []
synonym: "negative regulation of cytokine production during immune response" RELATED [GOC:dph]
synonym: "negative regulation of cytokine secretion involved in immune response" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002367 ! negatively regulates cytokine production involved in immune response
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4895
relationship: never_in_taxon NCBITaxon:4932
relationship: RO:0002212 GO:0002367 ! negatively regulates cytokine production involved in immune response
[Term]
id: GO:0002720
name: positive regulation of cytokine production involved in immune response
alt_id: GO:0002741
alt_id: GO:0002744
def: "Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add]
synonym: "activation of cytokine production during immune response" NARROW []
synonym: "positive regulation of cytokine biosynthetic process involved in immune response" NARROW []
synonym: "positive regulation of cytokine production during immune response" RELATED [GOC:dph]
synonym: "positive regulation of cytokine secretion involved in immune response" NARROW []
synonym: "stimulation of cytokine production during immune response" NARROW []
synonym: "up regulation of cytokine production during immune response" RELATED []
synonym: "up-regulation of cytokine production during immune response" RELATED []
synonym: "upregulation of cytokine production during immune response" RELATED []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002367 ! positively regulates cytokine production involved in immune response
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4895
relationship: never_in_taxon NCBITaxon:4932
relationship: RO:0002213 GO:0002367 ! positively regulates cytokine production involved in immune response
[Term]
id: GO:0002721
name: regulation of B cell cytokine production
def: "Any process that modulates the frequency, rate, or extent of B cell cytokine production." [GOC:add]
synonym: "regulation of B lymphocyte cytokine production" EXACT []
synonym: "regulation of B-cell cytokine production" EXACT []
synonym: "regulation of B-lymphocyte cytokine production" EXACT []
is_a: GO:0002712 ! regulation of B cell mediated immunity
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002368 ! regulates (processual) B cell cytokine production
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: RO:0002211 GO:0002368 ! regulates (processual) B cell cytokine production
[Term]
id: GO:0002722
name: negative regulation of B cell cytokine production
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell cytokine production." [GOC:add]
synonym: "down regulation of B cell cytokine production" EXACT []
synonym: "down-regulation of B cell cytokine production" EXACT []
synonym: "downregulation of B cell cytokine production" EXACT []
synonym: "inhibition of B cell cytokine production" NARROW []
synonym: "negative regulation of B lymphocyte cytokine production" EXACT []
synonym: "negative regulation of B-cell cytokine production" EXACT []
synonym: "negative regulation of B-lymphocyte cytokine production" EXACT []
is_a: GO:0002713 ! negative regulation of B cell mediated immunity
is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response
is_a: GO:0002721 ! regulation of B cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002368 ! negatively regulates B cell cytokine production
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: RO:0002212 GO:0002368 ! negatively regulates B cell cytokine production
[Term]
id: GO:0002723
name: positive regulation of B cell cytokine production
def: "Any process that activates or increases the frequency, rate, or extent of B cell cytokine production." [GOC:add]
synonym: "activation of B cell cytokine production" NARROW []
synonym: "positive regulation of B lymphocyte cytokine production" EXACT []
synonym: "positive regulation of B-cell cytokine production" EXACT []
synonym: "positive regulation of B-lymphocyte cytokine production" EXACT []
synonym: "stimulation of B cell cytokine production" NARROW []
synonym: "up regulation of B cell cytokine production" EXACT []
synonym: "up-regulation of B cell cytokine production" EXACT []
synonym: "upregulation of B cell cytokine production" EXACT []
is_a: GO:0002714 ! positive regulation of B cell mediated immunity
is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response
is_a: GO:0002721 ! regulation of B cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002368 ! positively regulates B cell cytokine production
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: RO:0002213 GO:0002368 ! positively regulates B cell cytokine production
[Term]
id: GO:0002724
name: regulation of T cell cytokine production
def: "Any process that modulates the frequency, rate, or extent of T cell cytokine production." [GOC:add]
synonym: "regulation of T lymphocyte cytokine production" EXACT []
synonym: "regulation of T-cell cytokine production" EXACT []
synonym: "regulation of T-lymphocyte cytokine production" EXACT []
is_a: GO:0002709 ! regulation of T cell mediated immunity
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002369 ! regulates (processual) T cell cytokine production
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: RO:0002211 GO:0002369 ! regulates (processual) T cell cytokine production
[Term]
id: GO:0002725
name: negative regulation of T cell cytokine production
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production." [GOC:add]
synonym: "down regulation of T cell cytokine production" EXACT []
synonym: "down-regulation of T cell cytokine production" EXACT []
synonym: "downregulation of T cell cytokine production" EXACT []
synonym: "inhibition of T cell cytokine production" NARROW []
synonym: "negative regulation of T lymphocyte cytokine production" EXACT []
synonym: "negative regulation of T-cell cytokine production" EXACT []
synonym: "negative regulation of T-lymphocyte cytokine production" EXACT []
is_a: GO:0002710 ! negative regulation of T cell mediated immunity
is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response
is_a: GO:0002724 ! regulation of T cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002369 ! negatively regulates T cell cytokine production
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: RO:0002212 GO:0002369 ! negatively regulates T cell cytokine production
[Term]
id: GO:0002726
name: positive regulation of T cell cytokine production
def: "Any process that activates or increases the frequency, rate, or extent of T cell cytokine production." [GOC:add]
synonym: "activation of T cell cytokine production" NARROW []
synonym: "positive regulation of T lymphocyte cytokine production" EXACT []
synonym: "positive regulation of T-cell cytokine production" EXACT []
synonym: "positive regulation of T-lymphocyte cytokine production" EXACT []
synonym: "stimulation of T cell cytokine production" NARROW []
synonym: "up regulation of T cell cytokine production" EXACT []
synonym: "up-regulation of T cell cytokine production" EXACT []
synonym: "upregulation of T cell cytokine production" EXACT []
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response
is_a: GO:0002724 ! regulation of T cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002369 ! positively regulates T cell cytokine production
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: RO:0002213 GO:0002369 ! positively regulates T cell cytokine production
[Term]
id: GO:0002727
name: regulation of natural killer cell cytokine production
def: "Any process that modulates the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add]
synonym: "regulation of NK cell cytokine production" EXACT []
is_a: GO:0002715 ! regulation of natural killer cell mediated immunity
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002370 ! regulates (processual) natural killer cell cytokine production
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002211 GO:0002370 ! regulates (processual) natural killer cell cytokine production
[Term]
id: GO:0002728
name: negative regulation of natural killer cell cytokine production
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add]
synonym: "down regulation of natural killer cell cytokine production" EXACT []
synonym: "down-regulation of natural killer cell cytokine production" EXACT []
synonym: "downregulation of natural killer cell cytokine production" EXACT []
synonym: "inhibition of natural killer cell cytokine production" NARROW []
synonym: "negative regulation of NK cell cytokine production" EXACT []
is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity
is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response
is_a: GO:0002727 ! regulation of natural killer cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002370 ! negatively regulates natural killer cell cytokine production
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002212 GO:0002370 ! negatively regulates natural killer cell cytokine production
[Term]
id: GO:0002729
name: positive regulation of natural killer cell cytokine production
def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add]
synonym: "activation of natural killer cell cytokine production" NARROW []
synonym: "positive regulation of NK cell cytokine production" EXACT []
synonym: "stimulation of natural killer cell cytokine production" NARROW []
synonym: "up regulation of natural killer cell cytokine production" EXACT []
synonym: "up-regulation of natural killer cell cytokine production" EXACT []
synonym: "upregulation of natural killer cell cytokine production" EXACT []
is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity
is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response
is_a: GO:0002727 ! regulation of natural killer cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002370 ! positively regulates natural killer cell cytokine production
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002213 GO:0002370 ! positively regulates natural killer cell cytokine production
[Term]
id: GO:0002730
name: regulation of dendritic cell cytokine production
def: "Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add]
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002371 ! regulates (processual) dendritic cell cytokine production
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002211 GO:0002371 ! regulates (processual) dendritic cell cytokine production
[Term]
id: GO:0002731
name: negative regulation of dendritic cell cytokine production
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add]
synonym: "down regulation of dendritic cell cytokine production" EXACT []
synonym: "down-regulation of dendritic cell cytokine production" EXACT []
synonym: "downregulation of dendritic cell cytokine production" EXACT []
synonym: "inhibition of dendritic cell cytokine production" NARROW []
is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity
is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response
is_a: GO:0002730 ! regulation of dendritic cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002371 ! negatively regulates dendritic cell cytokine production
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002212 GO:0002371 ! negatively regulates dendritic cell cytokine production
[Term]
id: GO:0002732
name: positive regulation of dendritic cell cytokine production
def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add]
synonym: "activation of dendritic cell cytokine production" NARROW []
synonym: "stimulation of dendritic cell cytokine production" NARROW []
synonym: "up regulation of dendritic cell cytokine production" EXACT []
synonym: "up-regulation of dendritic cell cytokine production" EXACT []
synonym: "upregulation of dendritic cell cytokine production" EXACT []
is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity
is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response
is_a: GO:0002730 ! regulation of dendritic cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002371 ! positively regulates dendritic cell cytokine production
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002213 GO:0002371 ! positively regulates dendritic cell cytokine production
[Term]
id: GO:0002733
name: regulation of myeloid dendritic cell cytokine production
def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add]
is_a: GO:0002730 ! regulation of dendritic cell cytokine production
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002372 ! regulates (processual) myeloid dendritic cell cytokine production
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002211 GO:0002372 ! regulates (processual) myeloid dendritic cell cytokine production
[Term]
id: GO:0002734
name: negative regulation of myeloid dendritic cell cytokine production
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add]
synonym: "down regulation of myeloid dendritic cell cytokine production" EXACT []
synonym: "down-regulation of myeloid dendritic cell cytokine production" EXACT []
synonym: "downregulation of myeloid dendritic cell cytokine production" EXACT []
synonym: "inhibition of myeloid dendritic cell cytokine production" NARROW []
is_a: GO:0002731 ! negative regulation of dendritic cell cytokine production
is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production
is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002372 ! negatively regulates myeloid dendritic cell cytokine production
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002212 GO:0002372 ! negatively regulates myeloid dendritic cell cytokine production
[Term]
id: GO:0002735
name: positive regulation of myeloid dendritic cell cytokine production
def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add]
synonym: "activation of myeloid dendritic cell cytokine production" NARROW []
synonym: "stimulation of myeloid dendritic cell cytokine production" NARROW []
synonym: "up regulation of myeloid dendritic cell cytokine production" EXACT []
synonym: "up-regulation of myeloid dendritic cell cytokine production" EXACT []
synonym: "upregulation of myeloid dendritic cell cytokine production" EXACT []
is_a: GO:0002732 ! positive regulation of dendritic cell cytokine production
is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production
is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity
is_a: GO:0061081 ! positive regulation of myeloid leukocyte cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002372 ! positively regulates myeloid dendritic cell cytokine production
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002213 GO:0002372 ! positively regulates myeloid dendritic cell cytokine production
[Term]
id: GO:0002759
name: regulation of antimicrobial humoral response
def: "Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0002920 ! regulation of humoral immune response
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032101 ! regulation of response to external stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0019730 ! regulates (processual) antimicrobial humoral response
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002211 GO:0019730 ! regulates (processual) antimicrobial humoral response
[Term]
id: GO:0002760
name: positive regulation of antimicrobial humoral response
def: "Any process that activates or increases the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add]
synonym: "activation of antimicrobial humoral response" NARROW []
synonym: "stimulation of antimicrobial humoral response" NARROW []
synonym: "up regulation of antimicrobial humoral response" EXACT []
synonym: "up-regulation of antimicrobial humoral response" EXACT []
synonym: "upregulation of antimicrobial humoral response" EXACT []
is_a: GO:0002759 ! regulation of antimicrobial humoral response
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0002922 ! positive regulation of humoral immune response
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0032103 ! positive regulation of response to external stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0019730 ! positively regulates antimicrobial humoral response
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002213 GO:0019730 ! positively regulates antimicrobial humoral response
[Term]
id: GO:0002761
name: regulation of myeloid leukocyte differentiation
def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add]
is_a: GO:0045637 ! regulation of myeloid cell differentiation
is_a: GO:1902105 ! regulation of leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002573 ! regulates (processual) myeloid leukocyte differentiation
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002211 GO:0002573 ! regulates (processual) myeloid leukocyte differentiation
[Term]
id: GO:0002762
name: negative regulation of myeloid leukocyte differentiation
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add]
synonym: "down regulation of myeloid leukocyte differentiation" EXACT []
synonym: "down-regulation of myeloid leukocyte differentiation" EXACT []
synonym: "downregulation of myeloid leukocyte differentiation" EXACT []
synonym: "inhibition of myeloid leukocyte differentiation" NARROW []
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
is_a: GO:0045638 ! negative regulation of myeloid cell differentiation
is_a: GO:1902106 ! negative regulation of leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002573 ! negatively regulates myeloid leukocyte differentiation
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002212 GO:0002573 ! negatively regulates myeloid leukocyte differentiation
[Term]
id: GO:0002763
name: positive regulation of myeloid leukocyte differentiation
def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add]
synonym: "activation of myeloid leukocyte differentiation" NARROW []
synonym: "stimulation of myeloid leukocyte differentiation" NARROW []
synonym: "up regulation of myeloid leukocyte differentiation" EXACT []
synonym: "up-regulation of myeloid leukocyte differentiation" EXACT []
synonym: "upregulation of myeloid leukocyte differentiation" EXACT []
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
is_a: GO:0045639 ! positive regulation of myeloid cell differentiation
is_a: GO:1902107 ! positive regulation of leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002573 ! positively regulates myeloid leukocyte differentiation
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002213 GO:0002573 ! positively regulates myeloid leukocyte differentiation
[Term]
id: GO:0002775
name: antimicrobial peptide production
def: "The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002440 ! production of molecular mediator of immune response
relationship: never_in_taxon NCBITaxon:4895
relationship: part_of GO:0061844 ! antimicrobial humoral immune response mediated by antimicrobial peptide
[Term]
id: GO:0002776
name: antimicrobial peptide secretion
def: "The regulated release of an antimicrobial peptide from a cell or a tissue. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
is_a: GO:0002790 ! peptide secretion
relationship: never_in_taxon NCBITaxon:4895
relationship: part_of GO:0002775 ! antimicrobial peptide production
[Term]
id: GO:0002784
name: regulation of antimicrobial peptide production
def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide production." [GOC:add]
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
is_a: GO:0002759 ! regulation of antimicrobial humoral response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002775 ! regulates (processual) antimicrobial peptide production
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002211 GO:0002775 ! regulates (processual) antimicrobial peptide production
[Term]
id: GO:0002785
name: negative regulation of antimicrobial peptide production
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide production." [GOC:add]
synonym: "down regulation of antimicrobial peptide production" EXACT []
synonym: "down-regulation of antimicrobial peptide production" EXACT []
synonym: "downregulation of antimicrobial peptide production" EXACT []
synonym: "inhibition of antimicrobial peptide production" NARROW []
is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response
is_a: GO:0002784 ! regulation of antimicrobial peptide production
is_a: GO:0008348 ! negative regulation of antimicrobial humoral response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002775 ! negatively regulates antimicrobial peptide production
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002212 GO:0002775 ! negatively regulates antimicrobial peptide production
[Term]
id: GO:0002790
name: peptide secretion
def: "The controlled release of a peptide from a cell or a tissue." [GOC:add]
is_a: GO:0015833 ! peptide transport
is_a: GO:0046903 ! secretion
intersection_of: GO:0046903 ! secretion
intersection_of: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion
relationship: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion
[Term]
id: GO:0002791
name: regulation of peptide secretion
def: "Any process that modulates the frequency, rate, or extent of peptide secretion." [GOC:add]
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0090087 ! regulation of peptide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002790 ! regulates (processual) peptide secretion
relationship: RO:0002211 GO:0002790 ! regulates (processual) peptide secretion
[Term]
id: GO:0002792
name: negative regulation of peptide secretion
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion." [GOC:add]
synonym: "down regulation of peptide secretion" EXACT []
synonym: "down-regulation of peptide secretion" EXACT []
synonym: "downregulation of peptide secretion" EXACT []
synonym: "inhibition of peptide secretion" NARROW []
is_a: GO:0002791 ! regulation of peptide secretion
is_a: GO:0051048 ! negative regulation of secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002790 ! negatively regulates peptide secretion
relationship: RO:0002212 GO:0002790 ! negatively regulates peptide secretion
[Term]
id: GO:0002793
name: positive regulation of peptide secretion
def: "Any process that activates or increases the frequency, rate, or extent of peptide secretion." [GOC:add]
synonym: "activation of peptide secretion" NARROW []
synonym: "stimulation of peptide secretion" NARROW []
synonym: "up regulation of peptide secretion" EXACT []
synonym: "up-regulation of peptide secretion" EXACT []
synonym: "upregulation of peptide secretion" EXACT []
is_a: GO:0002791 ! regulation of peptide secretion
is_a: GO:0051047 ! positive regulation of secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002790 ! positively regulates peptide secretion
relationship: RO:0002213 GO:0002790 ! positively regulates peptide secretion
[Term]
id: GO:0002794
name: regulation of antimicrobial peptide secretion
def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add]
is_a: GO:0002784 ! regulation of antimicrobial peptide production
is_a: GO:0002791 ! regulation of peptide secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002776 ! regulates (processual) antimicrobial peptide secretion
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002211 GO:0002776 ! regulates (processual) antimicrobial peptide secretion
[Term]
id: GO:0002795
name: negative regulation of antimicrobial peptide secretion
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add]
synonym: "down regulation of antimicrobial peptide secretion" EXACT []
synonym: "down-regulation of antimicrobial peptide secretion" EXACT []
synonym: "downregulation of antimicrobial peptide secretion" EXACT []
synonym: "inhibition of antimicrobial peptide secretion" NARROW []
is_a: GO:0002785 ! negative regulation of antimicrobial peptide production
is_a: GO:0002792 ! negative regulation of peptide secretion
is_a: GO:0002794 ! regulation of antimicrobial peptide secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002776 ! negatively regulates antimicrobial peptide secretion
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002212 GO:0002776 ! negatively regulates antimicrobial peptide secretion
[Term]
id: GO:0002796
name: positive regulation of antimicrobial peptide secretion
def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add]
synonym: "activation of antimicrobial peptide secretion" NARROW []
synonym: "stimulation of antimicrobial peptide secretion" NARROW []
synonym: "up regulation of antimicrobial peptide secretion" EXACT []
synonym: "up-regulation of antimicrobial peptide secretion" EXACT []
synonym: "upregulation of antimicrobial peptide secretion" EXACT []
is_a: GO:0002225 ! positive regulation of antimicrobial peptide production
is_a: GO:0002793 ! positive regulation of peptide secretion
is_a: GO:0002794 ! regulation of antimicrobial peptide secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002776 ! positively regulates antimicrobial peptide secretion
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002213 GO:0002776 ! positively regulates antimicrobial peptide secretion
[Term]
id: GO:0002819
name: regulation of adaptive immune response
def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response." [GOC:add]
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002250 ! regulates (processual) adaptive immune response
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: RO:0002211 GO:0002250 ! regulates (processual) adaptive immune response
[Term]
id: GO:0002820
name: negative regulation of adaptive immune response
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response." [GOC:add]
synonym: "down regulation of adaptive immune response" EXACT []
synonym: "down-regulation of adaptive immune response" EXACT []
synonym: "downregulation of adaptive immune response" EXACT []
synonym: "inhibition of adaptive immune response" NARROW []
is_a: GO:0002819 ! regulation of adaptive immune response
is_a: GO:0050777 ! negative regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002250 ! negatively regulates adaptive immune response
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: RO:0002212 GO:0002250 ! negatively regulates adaptive immune response
[Term]
id: GO:0002821
name: positive regulation of adaptive immune response
def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response." [GOC:add]
synonym: "activation of adaptive immune response" NARROW []
synonym: "stimulation of adaptive immune response" NARROW []
synonym: "up regulation of adaptive immune response" EXACT []
synonym: "up-regulation of adaptive immune response" EXACT []
synonym: "upregulation of adaptive immune response" EXACT []
is_a: GO:0002819 ! regulation of adaptive immune response
is_a: GO:0050778 ! positive regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002250 ! positively regulates adaptive immune response
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: RO:0002213 GO:0002250 ! positively regulates adaptive immune response
[Term]
id: GO:0002822
name: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu]
is_a: GO:0002819 ! regulation of adaptive immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002460 ! regulates (processual) adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: RO:0002211 GO:0002460 ! regulates (processual) adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
[Term]
id: GO:0002823
name: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu]
is_a: GO:0002820 ! negative regulation of adaptive immune response
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002460 ! negatively regulates adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: RO:0002212 GO:0002460 ! negatively regulates adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
[Term]
id: GO:0002824
name: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu]
is_a: GO:0002821 ! positive regulation of adaptive immune response
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002460 ! positively regulates adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: RO:0002213 GO:0002460 ! positively regulates adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
[Term]
id: GO:0002828
name: regulation of type 2 immune response
def: "Any process that modulates the frequency, rate, or extent of a type 2 immune response." [GOC:add]
synonym: "regulation of T-helper 2 type immune response" NARROW [GOC:add]
synonym: "regulation of Th2 immune response" NARROW [GOC:add]
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0042092 ! regulates (processual) type 2 immune response
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002211 GO:0042092 ! regulates (processual) type 2 immune response
[Term]
id: GO:0002829
name: negative regulation of type 2 immune response
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response." [GOC:add]
synonym: "down regulation of type 2 immune response" EXACT []
synonym: "down-regulation of type 2 immune response" EXACT []
synonym: "downregulation of type 2 immune response" EXACT []
synonym: "inhibition of type 2 immune response" NARROW []
synonym: "negative regulation of T-helper 2 type immune response" NARROW [GOC:add]
synonym: "negative regulation of Th2 immune response" NARROW [GOC:add]
is_a: GO:0002828 ! regulation of type 2 immune response
is_a: GO:0050777 ! negative regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0042092 ! negatively regulates type 2 immune response
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002212 GO:0042092 ! negatively regulates type 2 immune response
[Term]
id: GO:0002830
name: positive regulation of type 2 immune response
def: "Any process that activates or increases the frequency, rate, or extent of a type 2 immune response." [GOC:add]
synonym: "activation of type 2 immune response" NARROW []
synonym: "positive regulation of T-helper 2 type immune response" NARROW [GOC:add]
synonym: "positive regulation of Th2 immune response" NARROW [GOC:add]
synonym: "stimulation of type 2 immune response" NARROW []
synonym: "up regulation of type 2 immune response" EXACT []
synonym: "up-regulation of type 2 immune response" EXACT []
synonym: "upregulation of type 2 immune response" EXACT []
is_a: GO:0002828 ! regulation of type 2 immune response
is_a: GO:0050778 ! positive regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0042092 ! positively regulates type 2 immune response
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002213 GO:0042092 ! positively regulates type 2 immune response
[Term]
id: GO:0002831
name: regulation of response to biotic stimulus
def: "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0009607 ! regulates (processual) response to biotic stimulus
relationship: RO:0002211 GO:0009607 ! regulates (processual) response to biotic stimulus
[Term]
id: GO:0002832
name: negative regulation of response to biotic stimulus
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "down regulation of response to biotic stimulus" EXACT []
synonym: "down-regulation of response to biotic stimulus" EXACT []
synonym: "downregulation of response to biotic stimulus" EXACT []
synonym: "inhibition of response to biotic stimulus" NARROW []
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0048585 ! negative regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0009607 ! negatively regulates response to biotic stimulus
relationship: RO:0002212 GO:0009607 ! negatively regulates response to biotic stimulus
[Term]
id: GO:0002833
name: positive regulation of response to biotic stimulus
def: "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "activation of response to biotic stimulus" NARROW []
synonym: "stimulation of response to biotic stimulus" NARROW []
synonym: "up regulation of response to biotic stimulus" EXACT []
synonym: "up-regulation of response to biotic stimulus" EXACT []
synonym: "upregulation of response to biotic stimulus" EXACT []
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0048584 ! positive regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0009607 ! positively regulates response to biotic stimulus
relationship: RO:0002213 GO:0009607 ! positively regulates response to biotic stimulus
[Term]
id: GO:0002886
name: regulation of myeloid leukocyte mediated immunity
def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add]
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002444 ! regulates (processual) myeloid leukocyte mediated immunity
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002211 GO:0002444 ! regulates (processual) myeloid leukocyte mediated immunity
[Term]
id: GO:0002887
name: negative regulation of myeloid leukocyte mediated immunity
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add]
synonym: "down regulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "down-regulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "downregulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "inhibition of myeloid leukocyte mediated immunity" NARROW []
is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002444 ! negatively regulates myeloid leukocyte mediated immunity
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002212 GO:0002444 ! negatively regulates myeloid leukocyte mediated immunity
[Term]
id: GO:0002888
name: positive regulation of myeloid leukocyte mediated immunity
def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add]
synonym: "activation of myeloid leukocyte mediated immunity" NARROW []
synonym: "stimulation of myeloid leukocyte mediated immunity" NARROW []
synonym: "up regulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "up-regulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "upregulation of myeloid leukocyte mediated immunity" EXACT []
is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002444 ! positively regulates myeloid leukocyte mediated immunity
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002213 GO:0002444 ! positively regulates myeloid leukocyte mediated immunity
[Term]
id: GO:0002889
name: regulation of immunoglobulin mediated immune response
def: "Any process that modulates the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add]
is_a: GO:0002712 ! regulation of B cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0016064 ! regulates (processual) immunoglobulin mediated immune response
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: RO:0002211 GO:0016064 ! regulates (processual) immunoglobulin mediated immune response
[Term]
id: GO:0002890
name: negative regulation of immunoglobulin mediated immune response
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add]
synonym: "down regulation of immunoglobulin mediated immune response" EXACT []
synonym: "down-regulation of immunoglobulin mediated immune response" EXACT []
synonym: "downregulation of immunoglobulin mediated immune response" EXACT []
synonym: "inhibition of immunoglobulin mediated immune response" NARROW []
is_a: GO:0002713 ! negative regulation of B cell mediated immunity
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0016064 ! negatively regulates immunoglobulin mediated immune response
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: RO:0002212 GO:0016064 ! negatively regulates immunoglobulin mediated immune response
[Term]
id: GO:0002891
name: positive regulation of immunoglobulin mediated immune response
def: "Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add]
synonym: "activation of immunoglobulin mediated immune response" NARROW []
synonym: "stimulation of immunoglobulin mediated immune response" NARROW []
synonym: "up regulation of immunoglobulin mediated immune response" EXACT []
synonym: "up-regulation of immunoglobulin mediated immune response" EXACT []
synonym: "upregulation of immunoglobulin mediated immune response" EXACT []
is_a: GO:0002714 ! positive regulation of B cell mediated immunity
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0016064 ! positively regulates immunoglobulin mediated immune response
relationship: in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: RO:0002213 GO:0016064 ! positively regulates immunoglobulin mediated immune response
[Term]
id: GO:0002901
name: mature B cell apoptotic process
def: "Any apoptotic process in a B cell that is mature, having left the bone marrow." [CL:0000785, GOC:add, GOC:mtg_apoptosis, ISBN:0781735149]
synonym: "apoptosis of mature B cells" EXACT []
synonym: "apoptosis of mature B lymphocytes" EXACT []
synonym: "apoptosis of mature B-cells" EXACT []
synonym: "apoptosis of mature B-lymphocytes" EXACT []
synonym: "mature B cell apoptosis" NARROW []
synonym: "mature B cell programmed cell death by apoptosis" EXACT []
synonym: "mature B lymphocyte apoptosis" EXACT []
synonym: "mature B lymphocyte programmed cell death by apoptosis" EXACT []
synonym: "mature B-cell apoptosis" EXACT []
synonym: "mature B-cell programmed cell death by apoptosis" EXACT []
synonym: "mature B-lymphocyte apoptosis" EXACT []
synonym: "mature B-lymphocyte programmed cell death by apoptosis" EXACT []
synonym: "programmed cell death of mature B cells by apoptosis" EXACT []
synonym: "programmed cell death of mature B lymphocytes by apoptosis" EXACT []
synonym: "programmed cell death of mature B-cells by apoptosis" EXACT []
synonym: "programmed cell death of mature B-lymphocytes by apoptosis" EXACT []
synonym: "programmed cell death, mature B cells" EXACT []
synonym: "programmed cell death, mature B lymphocytes" EXACT []
synonym: "programmed cell death, mature B-cells" EXACT []
synonym: "programmed cell death, mature B-lymphocytes" EXACT []
is_a: GO:0001783 ! B cell apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000066 CL:0000785 ! occurs in mature B cell
relationship: BFO:0000066 CL:0000785 ! occurs in mature B cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0001782 ! B cell homeostasis
[Term]
id: GO:0002902
name: regulation of B cell apoptotic process
def: "Any process that modulates the frequency, rate, or extent of B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "regulation of B cell apoptosis" NARROW []
is_a: GO:0070228 ! regulation of lymphocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0001783 ! regulates (processual) B cell apoptotic process
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002211 GO:0001783 ! regulates (processual) B cell apoptotic process
[Term]
id: GO:0002903
name: negative regulation of B cell apoptotic process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "down regulation of B cell apoptosis" EXACT []
synonym: "down-regulation of B cell apoptosis" EXACT []
synonym: "downregulation of B cell apoptosis" EXACT []
synonym: "inhibition of B cell apoptosis" NARROW []
synonym: "negative regulation of B cell apoptosis" NARROW []
is_a: GO:0002902 ! regulation of B cell apoptotic process
is_a: GO:0070229 ! negative regulation of lymphocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0001783 ! negatively regulates B cell apoptotic process
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002212 GO:0001783 ! negatively regulates B cell apoptotic process
[Term]
id: GO:0002904
name: positive regulation of B cell apoptotic process
def: "Any process that activates or increases the frequency, rate, or extent of B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "activation of B cell apoptosis" NARROW []
synonym: "positive regulation of B cell apoptosis" NARROW []
synonym: "stimulation of B cell apoptosis" NARROW []
synonym: "up regulation of B cell apoptosis" EXACT []
synonym: "up-regulation of B cell apoptosis" EXACT []
synonym: "upregulation of B cell apoptosis" EXACT []
is_a: GO:0002902 ! regulation of B cell apoptotic process
is_a: GO:0070230 ! positive regulation of lymphocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0001783 ! positively regulates B cell apoptotic process
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002213 GO:0001783 ! positively regulates B cell apoptotic process
[Term]
id: GO:0002905
name: regulation of mature B cell apoptotic process
def: "Any process that modulates the frequency, rate, or extent of mature B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "regulation of mature B cell apoptosis" NARROW []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0002902 ! regulation of B cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002901 ! regulates (processual) mature B cell apoptotic process
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002211 GO:0002901 ! regulates (processual) mature B cell apoptotic process
[Term]
id: GO:0002906
name: negative regulation of mature B cell apoptotic process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mature B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "down regulation of mature B cell apoptosis" EXACT []
synonym: "down-regulation of mature B cell apoptosis" EXACT []
synonym: "downregulation of mature B cell apoptosis" EXACT []
synonym: "inhibition of mature B cell apoptosis" NARROW []
synonym: "negative regulation of mature B cell apoptosis" NARROW []
is_a: GO:0002903 ! negative regulation of B cell apoptotic process
is_a: GO:0002905 ! regulation of mature B cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002901 ! negatively regulates mature B cell apoptotic process
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002212 GO:0002901 ! negatively regulates mature B cell apoptotic process
[Term]
id: GO:0002907
name: positive regulation of mature B cell apoptotic process
def: "Any process that activates or increases the frequency, rate, or extent of mature B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "activation of mature B cell apoptosis" NARROW []
synonym: "positive regulation of mature B cell apoptosis" NARROW []
synonym: "stimulation of mature B cell apoptosis" NARROW []
synonym: "up regulation of mature B cell apoptosis" EXACT []
synonym: "up-regulation of mature B cell apoptosis" EXACT []
synonym: "upregulation of mature B cell apoptosis" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0002904 ! positive regulation of B cell apoptotic process
is_a: GO:0002905 ! regulation of mature B cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002901 ! positively regulates mature B cell apoptotic process
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002213 GO:0002901 ! positively regulates mature B cell apoptotic process
[Term]
id: GO:0002920
name: regulation of humoral immune response
def: "Any process that modulates the frequency, rate, or extent of a humoral immune response." [GOC:add]
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006959 ! regulates (processual) humoral immune response
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002211 GO:0006959 ! regulates (processual) humoral immune response
[Term]
id: GO:0002921
name: negative regulation of humoral immune response
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response." [GOC:add]
synonym: "down regulation of humoral immune response" EXACT []
synonym: "down-regulation of humoral immune response" EXACT []
synonym: "downregulation of humoral immune response" EXACT []
synonym: "inhibition of humoral immune response" NARROW []
is_a: GO:0002920 ! regulation of humoral immune response
is_a: GO:0050777 ! negative regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006959 ! negatively regulates humoral immune response
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002212 GO:0006959 ! negatively regulates humoral immune response
[Term]
id: GO:0002922
name: positive regulation of humoral immune response
def: "Any process that activates or increases the frequency, rate, or extent of a humoral immune response." [GOC:add]
synonym: "activation of humoral immune response" NARROW []
synonym: "stimulation of humoral immune response" NARROW []
synonym: "up regulation of humoral immune response" EXACT []
synonym: "up-regulation of humoral immune response" EXACT []
synonym: "upregulation of humoral immune response" EXACT []
is_a: GO:0002920 ! regulation of humoral immune response
is_a: GO:0050778 ! positive regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006959 ! positively regulates humoral immune response
relationship: never_in_taxon NCBITaxon:4895
relationship: RO:0002213 GO:0006959 ! positively regulates humoral immune response
[Term]
id: GO:0002930
name: trabecular meshwork development
def: "The progression of the trabecular meshwork over time, from its formation to the mature structure. The trabecular meshwork is a fenestrated endothelial-like tissue situated at the intersection of the cornea and the iris. The trabecular meshwork provides drainage for the aqueous humor." [PMID:20568247]
is_a: GO:0009888 ! tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0005969 ! results in development of eye trabecular meshwork
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0043010 ! camera-type eye development
relationship: RO:0002296 UBERON:0005969 ! results in development of eye trabecular meshwork
created_by: hjd
creation_date: 2012-04-19T04:50:06Z
[Term]
id: GO:0002932
name: tendon sheath development
def: "The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move." [PMID:20696843]
is_a: GO:0061448 ! connective tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000304 ! results in development of tendon sheath
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0035989 ! tendon development
relationship: RO:0002296 UBERON:0000304 ! results in development of tendon sheath
created_by: hjd
creation_date: 2012-04-23T02:11:22Z
[Term]
id: GO:0002934
name: desmosome organization
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd]
is_a: GO:0045216 ! cell-cell junction organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0030057 ! results in organization of desmosome
relationship: RO:0002592 GO:0030057 ! results in organization of desmosome
created_by: hjd
creation_date: 2012-05-08T02:59:08Z
[Term]
id: GO:0002941
name: synoviocyte proliferation
def: "The multiplication or reproduction of type B synoviocytes by cell division, resulting in the expansion of their population. A type B synoviocyte is a fibroblast-like cell found in synovial tissues." [PMID:10770586, PMID:9546370]
is_a: GO:0050673 ! epithelial cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0002301 ! acts on population of type B synovial cell
relationship: never_in_taxon NCBITaxon:4751 ! Fungi
relationship: RO:0012003 CL:0002301 ! acts on population of type B synovial cell
created_by: hjd
creation_date: 2012-11-16T14:25:45Z
[Term]
id: GO:0003002
name: regionalization
def: "The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:isa_complete]
synonym: "pattern formation" RELATED [GOC:dph]
is_a: GO:0007389 ! pattern specification process
relationship: in_taxon NCBITaxon:131567 ! cellular organism
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
[Term]
id: GO:0003006
name: developmental process involved in reproduction
def: "A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete]
synonym: "puberty" NARROW [GOC:dph]
synonym: "reproductive developmental process" RELATED [GOC:dph, GOC:tb]
is_a: GO:0022414 ! reproductive process
is_a: GO:0032502 ! developmental process
intersection_of: GO:0022414 ! reproductive process
intersection_of: GO:0032502 ! developmental process
[Term]
id: GO:0003007
name: heart morphogenesis
def: "The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete]
synonym: "cardiac morphogenesis" RELATED []
is_a: GO:0009887 ! animal organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0007100 ! results in morphogenesis of primary circulatory organ
relationship: in_taxon NCBITaxon:33213 ! Bilateria
relationship: part_of GO:0007507 ! heart development
relationship: RO:0002298 UBERON:0007100 ! results in morphogenesis of primary circulatory organ
[Term]
id: GO:0003008
name: system process
def: "A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective." [GOC:mtg_cardio]
synonym: "organ system process" EXACT []
is_a: GO:0032501 ! multicellular organismal process
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
[Term]
id: GO:0003009
name: skeletal muscle contraction
def: "A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control." [GOC:mtg_cardio, GOC:mtg_muscle]
is_a: GO:0006941 ! striated muscle contraction
intersection_of: GO:0006936 ! muscle contraction
intersection_of: BFO:0000066 UBERON:0001134 ! occurs in skeletal muscle tissue
relationship: BFO:0000066 UBERON:0001134 ! occurs in skeletal muscle tissue
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: part_of GO:0050881 ! musculoskeletal movement
[Term]
id: GO:0003012
name: muscle system process
def: "An organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio]
subset: goslim_drosophila
subset: goslim_generic
synonym: "muscle physiological process" RELATED []
is_a: GO:0003008 ! system process
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
[Term]
id: GO:0003013
name: circulatory system process
def: "An organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism." [GOC:mtg_cardio]
subset: goslim_chembl
subset: goslim_generic
xref: Wikipedia:Circulatory_system
is_a: GO:0003008 ! system process
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
[Term]
id: GO:0003014
name: renal system process
def: "An organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila)." [GOC:cjm, GOC:mtg_cardio, GOC:mtg_kidney_jan10]
subset: goslim_generic
synonym: "excretory system process" EXACT []
synonym: "kidney system process" RELATED []
is_a: GO:0003008 ! system process
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
[Term]
id: GO:0003015
name: heart process
def: "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio]
synonym: "cardiac process" RELATED []
is_a: GO:0003013 ! circulatory system process
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
[Term]
id: GO:0003016
name: respiratory system process
alt_id: GO:0010802
def: "A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange." [GOC:dph, GOC:mtg_cardio, GOC:tb]
subset: goslim_generic
synonym: "respiratory gaseous exchange" EXACT []
is_a: GO:0003008 ! system process
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
relationship: part_of GO:0007585 ! respiratory gaseous exchange by respiratory system
[Term]
id: GO:0003017
name: lymph circulation
def: "The flow of lymph through the body of an animal." [GOC:mtg_cardio]
is_a: GO:0003013 ! circulatory system process
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
[Term]
id: GO:0003018
name: vascular process in circulatory system
def: "A circulatory process that occurs at the level of the vasculature." [GOC:mtg_cardio]
synonym: "vasculature process" EXACT []
is_a: GO:0003013 ! circulatory system process
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
[Term]
id: GO:0003019
name: central nervous system control of baroreceptor feedback
def: "The neurological process in which nerve impulses arising in the aorta or the carotid sinuses travel to the medulla and reach the nucleus of tractus solaris." [GOC:mtg_cardio, ISBN:0323031951]
is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: part_of GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback
[Term]
id: GO:0003020
name: detection of reduced oxygen by chemoreceptor signaling
def: "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951]
synonym: "detection of reduced oxygen by chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0070483 ! detection of hypoxia
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: part_of GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling
[Term]
id: GO:0003022
name: detection of pH by chemoreceptor signaling
def: "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors." [GOC:mtg_cardio, ISBN:0323031951]
synonym: "detection of pH by chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003030 ! detection of hydrogen ion
[Term]
id: GO:0003025
name: regulation of systemic arterial blood pressure by baroreceptor feedback
def: "The neural regulation of blood pressure in which baroreceptors sense the amount of stretch occurring in vessels and respond to the input via central nervous system control." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "baroreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure
relationship: in_taxon NCBITaxon:33208 ! Metazoa
[Term]
id: GO:0003027
name: regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling
def: "The process that modulates blood pressure by the action of chemoreceptors found in the carotid bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "carotid body chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
synonym: "carotid body chemoreceptor response to lowering of systemic arterial blood pressure" EXACT [GOC:dph]
synonym: "regulation of systemic arterial blood pressure by carotid body chemoreceptor signalling" EXACT [GOC:mah]
synonym: "vagal reflex" BROAD []
is_a: GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling
relationship: in_taxon NCBITaxon:33208 ! Metazoa
[Term]
id: GO:0003029
name: detection of hypoxic conditions in blood by carotid body chemoreceptor signaling
def: "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies." [GOC:mtg_cardio]
synonym: "detection of hypoxic conditions in blood by carotid body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling
[Term]
id: GO:0003030
name: detection of hydrogen ion
def: "The series of events in which a hydrogen ion stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio]
is_a: GO:0009593 ! detection of chemical stimulus
[Term]
id: GO:0003032
name: detection of oxygen
def: "The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio]
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0070482 ! response to oxygen levels
[Term]
id: GO:0003039
name: detection of reduced oxygen by carotid body chemoreceptor signaling
def: "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio]
synonym: "detection of reduced oxygen by carotid body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003020 ! detection of reduced oxygen by chemoreceptor signaling
relationship: in_taxon NCBITaxon:33208 ! Metazoa
relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling
[Term]
id: GO:0003044
name: regulation of systemic arterial blood pressure mediated by a chemical signal
def: "The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine." [GOC:mtg_cardio]
synonym: "blood pressure regulation mediated by a chemical signal" EXACT []
is_a: GO:0003073 ! regulation of systemic arterial blood pressure
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
[Term]
id: GO:0003071
name: renal system process involved in regulation of systemic arterial blood pressure
def: "Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "renal control of blood pressure" EXACT []
synonym: "renal regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003014 ! renal system process
intersection_of: GO:0003014 ! renal system process
intersection_of: part_of GO:0003073 ! regulation of systemic arterial blood pressure
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure
[Term]
id: GO:0003073
name: regulation of systemic arterial blood pressure
def: "The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:mtg_cardio]
is_a: GO:0008217 ! regulation of blood pressure
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
[Term]
id: GO:0003081
name: regulation of systemic arterial blood pressure by renin-angiotensin
def: "The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system." [GOC:mtg_cardio]
synonym: "blood pressure regulation by renin-angiotensin" EXACT []
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
[Term]
id: GO:0003091
name: renal water homeostasis
def: "Renal process involved in the maintenance of an internal steady state of water in the body." [GOC:mtg_cardio]
synonym: "water homeostasis by the renal system" EXACT []
xref: Reactome:R-HSA-432040 "Vasopressin regulates renal water homeostasis via Aquaporins"
is_a: GO:0003014 ! renal system process
is_a: GO:0050891 ! multicellular organismal-level water homeostasis
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
[Term]
id: GO:0003093
name: regulation of glomerular filtration
def: "Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio]
is_a: GO:0001977 ! renal system process involved in regulation of blood volume
is_a: GO:0098801 ! regulation of renal system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0003094 ! regulates (processual) glomerular filtration
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
relationship: RO:0002211 GO:0003094 ! regulates (processual) glomerular filtration
[Term]
id: GO:0003094
name: glomerular filtration
def: "The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein." [GOC:mtg_cardio, GOC:sart, ISBN:0721643949]
is_a: GO:0097205 ! renal filtration
intersection_of: GO:0097205 ! renal filtration
intersection_of: BFO:0000066 UBERON:0000074 ! occurs in renal glomerulus
relationship: BFO:0000066 UBERON:0000074 ! occurs in renal glomerulus
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
[Term]
id: GO:0003096
name: renal sodium ion transport
def: "The directed movement of sodium ions (Na+) by the renal system." [GOC:mtg_cardio]
is_a: GO:0003014 ! renal system process
is_a: GO:0006814 ! sodium ion transport
intersection_of: GO:0006814 ! sodium ion transport
intersection_of: BFO:0000066 UBERON:0001008 ! occurs in renal system
relationship: BFO:0000066 UBERON:0001008 ! occurs in renal system
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
[Term]
id: GO:0003097
name: renal water transport
def: "The directed movement of water (H2O) by the renal system." [GOC:mtg_cardio]
is_a: GO:0003014 ! renal system process
is_a: GO:0006833 ! water transport
intersection_of: GO:0006833 ! water transport
intersection_of: BFO:0000066 UBERON:0001008 ! occurs in renal system
relationship: BFO:0000066 UBERON:0001008 ! occurs in renal system
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
relationship: part_of GO:0003091 ! renal water homeostasis
[Term]
id: GO:0003104
name: positive regulation of glomerular filtration
def: "Any process that activates or increases the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio]
is_a: GO:0003093 ! regulation of glomerular filtration
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0003094 ! positively regulates glomerular filtration
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
relationship: RO:0002213 GO:0003094 ! positively regulates glomerular filtration
[Term]
id: GO:0003105
name: negative regulation of glomerular filtration
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio]
is_a: GO:0003093 ! regulation of glomerular filtration
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0003094 ! negatively regulates glomerular filtration
relationship: never_in_taxon NCBITaxon:2
relationship: never_in_taxon NCBITaxon:2157
relationship: never_in_taxon NCBITaxon:4896
relationship: never_in_taxon NCBITaxon:4932
relationship: RO:0002212 GO:0003094 ! negatively regulates glomerular filtration
[Term]
id: GO:0003131
name: mesodermal-endodermal cell signaling
def: "Any process that mediates the transfer of information from mesodermal cells to endodermal cells." [GOC:mtg_heart]
synonym: "mesodermal-endodermal cell signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: RO:0002231 CL:0000222 ! has start location mesodermal cell
intersection_of: RO:0002232 CL:0000223 ! has end location endodermal cell
relationship: RO:0002231 CL:0000222 ! has start location mesodermal cell
relationship: RO:0002232 CL:0000223 ! has end location endodermal cell
created_by: tb
creation_date: 2009-09-22T03:07:34Z
[Term]
id: GO:0003133
name: endodermal-mesodermal cell signaling
def: "Any process that mediates the transfer of information from endodermal cells to mesodermal cells." [GOC:mtg_heart]
synonym: "endodermal-mesodermal cell signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: RO:0002231 CL:0000223 ! has start location endodermal cell
intersection_of: RO:0002232 CL:0000222 ! has end location mesodermal cell
relationship: RO:0002231 CL:0000223 ! has start location endodermal cell
relationship: RO:0002232 CL:0000222 ! has end location mesodermal cell
created_by: tb
creation_date: 2009-09-22T03:10:29Z
[Term]
id: GO:0003142
name: cardiogenic plate morphogenesis
def: "The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field." [GOC:mtg_heart]
synonym: "cardiac crescent morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0004139 ! results in morphogenesis of cardiogenic plate
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: RO:0002298 UBERON:0004139 ! results in morphogenesis of cardiogenic plate
created_by: tb
creation_date: 2009-09-22T04:12:18Z
[Term]
id: GO:0003143
name: embryonic heart tube morphogenesis
def: "The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0060562 ! epithelial tube morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0004141 ! results in morphogenesis of heart tube
relationship: in_taxon NCBITaxon:33213 ! Bilateria
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0035050 ! embryonic heart tube development
relationship: part_of GO:0048562 ! embryonic organ morphogenesis
relationship: RO:0002298 UBERON:0004141 ! results in morphogenesis of heart tube
created_by: tb
creation_date: 2009-09-22T04:21:17Z
[Term]
id: GO:0003144
name: embryonic heart tube formation
def: "The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart]
is_a: GO:0001838 ! embryonic epithelial tube formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0004141 ! results in formation of anatomical entity heart tube
relationship: in_taxon NCBITaxon:33213 ! Bilateria
relationship: part_of GO:0003143 ! embryonic heart tube morphogenesis
relationship: RO:0002297 UBERON:0004141 ! results in formation of anatomical entity heart tube
created_by: tb
creation_date: 2009-09-22T04:22:34Z
[Term]
id: GO:0003145
name: embryonic heart tube formation via epithelial folding
def: "The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis." [GOC:mtg_heart]
is_a: GO:0003144 ! embryonic heart tube formation
relationship: in_taxon NCBITaxon:33213 ! Bilateria
created_by: tb
creation_date: 2009-09-22T04:26:03Z
[Term]
id: GO:0003147
name: neural crest cell migration involved in heart formation
def: "The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation." [GOC:mtg_heart]
is_a: GO:0001755 ! neural crest cell migration
is_a: GO:0060974 ! cell migration involved in heart formation
intersection_of: GO:0001755 ! neural crest cell migration
intersection_of: part_of GO:0060914 ! heart formation
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0060914 ! heart formation
relationship: part_of GO:0061308 ! cardiac neural crest cell development involved in heart development
created_by: tb
creation_date: 2009-09-22T04:29:55Z
[Term]
id: GO:0003148
name: outflow tract septum morphogenesis
def: "The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract." [GOC:mtg_heart]
is_a: GO:0060411 ! cardiac septum morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0004142 ! results in morphogenesis of outflow tract septum
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0003151 ! outflow tract morphogenesis
relationship: RO:0002298 UBERON:0004142 ! results in morphogenesis of outflow tract septum
created_by: tb
creation_date: 2009-09-22T07:51:01Z
[Term]
id: GO:0003149
name: membranous septum morphogenesis
def: "The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum." [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0004666 ! results in morphogenesis of interventricular septum membranous part
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0060412 ! ventricular septum morphogenesis
relationship: RO:0002298 UBERON:0004666 ! results in morphogenesis of interventricular septum membranous part
created_by: tb
creation_date: 2009-09-22T07:51:41Z
[Term]
id: GO:0003150
name: muscular septum morphogenesis
def: "The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum." [GOC:mtg_heart]
is_a: GO:0060415 ! muscle tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0004667 ! results in morphogenesis of interventricular septum muscular part
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0060412 ! ventricular septum morphogenesis
relationship: RO:0002298 UBERON:0004667 ! results in morphogenesis of interventricular septum muscular part
created_by: tb
creation_date: 2009-09-22T07:53:28Z
[Term]
id: GO:0003151
name: outflow tract morphogenesis
def: "The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart, UBERON:0004145]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0004145 ! results in morphogenesis of outflow tract
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: RO:0002298 UBERON:0004145 ! results in morphogenesis of outflow tract
created_by: tb
creation_date: 2009-09-22T07:59:24Z
[Term]
id: GO:0003152
name: morphogenesis of an epithelial fold involved in embryonic heart tube formation
def: "The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation." [GOC:mtg_heart]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0060571 ! morphogenesis of an epithelial fold
intersection_of: GO:0060571 ! morphogenesis of an epithelial fold
intersection_of: part_of GO:0003144 ! embryonic heart tube formation
relationship: in_taxon NCBITaxon:33213 ! Bilateria
relationship: part_of GO:0003144 ! embryonic heart tube formation
relationship: part_of GO:0003145 ! embryonic heart tube formation via epithelial folding
created_by: tb
creation_date: 2009-09-23T10:10:24Z
[Term]
id: GO:0003156
name: regulation of animal organ formation
def: "Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment." [GOC:dph, GOC:mtg_heart, GOC:tb]
is_a: GO:2000027 ! regulation of animal organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048645 ! regulates (processual) animal organ formation
relationship: in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: RO:0002211 GO:0048645 ! regulates (processual) animal organ formation
created_by: tb
creation_date: 2009-09-30T11:21:09Z
[Term]
id: GO:0003157
name: endocardium development
def: "The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002165 ! results in development of endocardium
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0007507 ! heart development
relationship: RO:0002296 UBERON:0002165 ! results in development of endocardium
created_by: dph
creation_date: 2009-10-01T12:42:27Z
[Term]
id: GO:0003158
name: endothelium development
def: "The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart]
is_a: GO:0060429 ! epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001986 ! results in development of endothelium
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002296 UBERON:0001986 ! results in development of endothelium
created_by: dph
creation_date: 2009-10-01T12:50:57Z
[Term]
id: GO:0003159
name: morphogenesis of an endothelium
def: "The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart]
is_a: GO:0002009 ! morphogenesis of an epithelium
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001986 ! results in morphogenesis of endothelium
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0003158 ! endothelium development
relationship: RO:0002298 UBERON:0001986 ! results in morphogenesis of endothelium
created_by: dph
creation_date: 2009-10-01T01:34:06Z
[Term]
id: GO:0003160
name: endocardium morphogenesis
def: "The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002165 ! results in morphogenesis of endocardium
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0003157 ! endocardium development
relationship: RO:0002298 UBERON:0002165 ! results in morphogenesis of endocardium
created_by: dph
creation_date: 2009-10-01T01:37:26Z
[Term]
id: GO:0003161
name: cardiac conduction system development
def: "The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat." [GOC:mtg_heart]
synonym: "cardiac impulse conducting system development" EXACT [GOC:mtg_heart]
synonym: "heart conduction system development" EXACT [GOC:mtg_heart]
is_a: GO:0048738 ! cardiac muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002350 ! results in development of conducting system of heart
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002296 UBERON:0002350 ! results in development of conducting system of heart
created_by: dph
creation_date: 2009-10-01T01:57:16Z
[Term]
id: GO:0003162
name: atrioventricular node development
def: "The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system." [GOC:mtg_heart]
synonym: "AV node development" EXACT [GOC:mtg_heart]
is_a: GO:0048738 ! cardiac muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002352 ! results in development of atrioventricular node
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0003161 ! cardiac conduction system development
relationship: RO:0002296 UBERON:0002352 ! results in development of atrioventricular node
created_by: dph
creation_date: 2009-10-01T02:05:13Z
[Term]
id: GO:0003163
name: sinoatrial node development
def: "The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node." [GOC:mtg_heart]
synonym: "SA node development" EXACT [GOC:mtg_heart]
synonym: "SAN development" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "sinus node development" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0003228 ! atrial cardiac muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002351 ! results in development of sinoatrial node
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0003161 ! cardiac conduction system development
relationship: RO:0002296 UBERON:0002351 ! results in development of sinoatrial node
created_by: dph
creation_date: 2009-10-01T02:06:09Z
[Term]
id: GO:0003164
name: His-Purkinje system development
def: "The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart]
is_a: GO:0003229 ! ventricular cardiac muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0004146 ! results in development of His-Purkinje system
relationship: in_taxon NCBITaxon:32523 ! Tetrapoda
relationship: part_of GO:0003161 ! cardiac conduction system development
relationship: RO:0002296 UBERON:0004146 ! results in development of His-Purkinje system
created_by: dph
creation_date: 2009-10-01T02:07:12Z
[Term]
id: GO:0003165
name: Purkinje myocyte development
def: "The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]
synonym: "cardiac Purkinje fiber development" EXACT []
is_a: GO:0003229 ! ventricular cardiac muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002354 ! results in development of cardiac Purkinje fiber
relationship: in_taxon NCBITaxon:32523 ! Tetrapoda
relationship: part_of GO:0003164 ! His-Purkinje system development
relationship: RO:0002296 UBERON:0002354 ! results in development of cardiac Purkinje fiber
created_by: dph
creation_date: 2009-10-01T02:07:50Z
[Term]
id: GO:0003166
name: bundle of His development
def: "The process whose specific outcome is the progression of the bundle of His over time, from its formation to the mature structure. The bundle of His is part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart]
synonym: "atrioventricular bundle development" EXACT [GOC:mtg_heart]
is_a: GO:0003229 ! ventricular cardiac muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002353 ! results in development of bundle of His
relationship: in_taxon NCBITaxon:32523 ! Tetrapoda
relationship: part_of GO:0003164 ! His-Purkinje system development
relationship: RO:0002296 UBERON:0002353 ! results in development of bundle of His
created_by: dph
creation_date: 2009-10-01T02:08:43Z
[Term]
id: GO:0003167
name: atrioventricular bundle cell differentiation
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the atrioventricular bundle. These cells are specialized cardiomyocytes that transmit signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart]
synonym: "AV bundle cell differentiation" EXACT [GOC:mtg_heart]
is_a: GO:0060932 ! His-Purkinje system cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0010005 ! results in acquisition of features of atrioventricular bundle cell
relationship: in_taxon NCBITaxon:32523 ! Tetrapoda
relationship: part_of GO:0003166 ! bundle of His development
relationship: RO:0002315 CL:0010005 ! results in acquisition of features of atrioventricular bundle cell
created_by: dph
creation_date: 2009-10-01T02:48:23Z
[Term]
id: GO:0003168
name: Purkinje myocyte differentiation
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]
synonym: "cardiac Purkinje fiber cell differentiation" EXACT []
is_a: GO:0060932 ! His-Purkinje system cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0002068 ! results in acquisition of features of Purkinje myocyte
relationship: in_taxon NCBITaxon:32523 ! Tetrapoda
relationship: part_of GO:0003165 ! Purkinje myocyte development
relationship: RO:0002315 CL:0002068 ! results in acquisition of features of Purkinje myocyte
created_by: dph
creation_date: 2009-10-01T02:49:54Z
[Term]
id: GO:0003169
name: coronary vein morphogenesis
def: "The process in which the anatomical structures of veins of the heart are generated and organized." [GOC:mtg_heart]
is_a: GO:0048845 ! venous blood vessel morphogenesis
is_a: GO:0060977 ! coronary vasculature morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0004148 ! results in morphogenesis of cardiac vein
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002298 UBERON:0004148 ! results in morphogenesis of cardiac vein
created_by: dph
creation_date: 2009-10-08T10:45:41Z
[Term]
id: GO:0003170
name: heart valve development
def: "The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion." [GOC:mtg_heart]
synonym: "cardiac valve development" EXACT [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000946 ! results in development of cardiac valve
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0007507 ! heart development
relationship: RO:0002296 UBERON:0000946 ! results in development of cardiac valve
created_by: dph
creation_date: 2009-10-08T10:50:09Z
[Term]
id: GO:0003171
name: atrioventricular valve development
def: "The progression of the atrioventricular valve over time, from its formation to the mature structure." [GOC:mtg_heart]
synonym: "AV valve development" EXACT [GOC:mah]
is_a: GO:0003170 ! heart valve development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002133 ! results in development of atrioventricular valve
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002296 UBERON:0002133 ! results in development of atrioventricular valve
created_by: dph
creation_date: 2009-10-08T11:14:21Z
[Term]
id: GO:0003172
name: sinoatrial valve development
def: "The progression of the sinoatrial valve over time, from its formation to the mature structure." [GOC:mtg_heart]
synonym: "SA valve development" EXACT [GOC:mah]
is_a: GO:0003170 ! heart valve development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002086 ! results in development of sinoatrial valve
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002296 UBERON:0002086 ! results in development of sinoatrial valve
created_by: dph
creation_date: 2009-10-08T11:15:39Z
[Term]
id: GO:0003173
name: ventriculo bulbo valve development
def: "The progression of the ventriculo bulbo valve over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003170 ! heart valve development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0004149 ! results in development of ventriculo bulbo valve
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002296 UBERON:0004149 ! results in development of ventriculo bulbo valve
created_by: dph
creation_date: 2009-10-08T11:16:25Z
[Term]
id: GO:0003174
name: mitral valve development
def: "The progression of the mitral valve over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003171 ! atrioventricular valve development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002135 ! results in development of mitral valve
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002296 UBERON:0002135 ! results in development of mitral valve
created_by: dph
creation_date: 2009-10-08T11:17:22Z
[Term]
id: GO:0003175
name: tricuspid valve development
def: "The progression of the tricuspid valve over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003171 ! atrioventricular valve development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002134 ! results in development of tricuspid valve
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002296 UBERON:0002134 ! results in development of tricuspid valve
created_by: dph
creation_date: 2009-10-08T11:18:12Z
[Term]
id: GO:0003176
name: aortic valve development
def: "The progression of the aortic valve over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:1905314 ! semi-lunar valve development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002137 ! results in development of aortic valve
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002296 UBERON:0002137 ! results in development of aortic valve
created_by: dph
creation_date: 2009-10-08T11:18:55Z
[Term]
id: GO:0003177
name: pulmonary valve development
def: "The progression of the pulmonary valve over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:1905314 ! semi-lunar valve development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002146 ! results in development of pulmonary valve
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002296 UBERON:0002146 ! results in development of pulmonary valve
created_by: dph
creation_date: 2009-10-08T11:19:44Z
[Term]
id: GO:0003178
name: coronary sinus valve development
def: "The progression of the valve of the coronary sinus over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003170 ! heart valve development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0004150 ! results in development of coronary sinus valve
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: RO:0002296 UBERON:0004150 ! results in development of coronary sinus valve
created_by: dph
creation_date: 2009-10-08T11:21:43Z
[Term]
id: GO:0003179
name: heart valve morphogenesis
def: "The process in which the structure of a heart valve is generated and organized." [GOC:mtg_heart]
synonym: "heart valve remodeling" NARROW [GOC:vk, GOC:yaf]
synonym: "heart valve remodelling" NARROW [GOC:vk, GOC:yaf]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0000946 ! results in morphogenesis of cardiac valve
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0003170 ! heart valve development
relationship: RO:0002298 UBERON:0000946 ! results in morphogenesis of cardiac valve
created_by: dph
creation_date: 2009-10-08T11:23:48Z
[Term]
id: GO:0003180
name: aortic valve morphogenesis
def: "The process in which the structure of the aortic valve is generated and organized." [GOC:mtg_heart]
is_a: GO:0003179 ! heart valve morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002137 ! results in morphogenesis of aortic valve
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0003176 ! aortic valve development
relationship: RO:0002298 UBERON:0002137 ! results in morphogenesis of aortic valve
created_by: dph
creation_date: 2009-10-08T11:29:42Z
[Term]
id: GO:0003181
name: atrioventricular valve morphogenesis
def: "The process in which the structure of the atrioventricular valve is generated and organized." [GOC:mtg_heart]
synonym: "AV valve morphogenesis" EXACT [GOC:mah]
is_a: GO:0003179 ! heart valve morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002133 ! results in morphogenesis of atrioventricular valve
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0003171 ! atrioventricular valve development
relationship: RO:0002298 UBERON:0002133 ! results in morphogenesis of atrioventricular valve
created_by: dph
creation_date: 2009-10-08T11:31:59Z
[Term]
id: GO:0003182
name: coronary sinus valve morphogenesis
def: "The process in which the structure of the coronary sinus valve is generated and organized." [GOC:mtg_heart]
is_a: GO:0003179 ! heart valve morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0004150 ! results in morphogenesis of coronary sinus valve
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0003178 ! coronary sinus valve development
relationship: RO:0002298 UBERON:0004150 ! results in morphogenesis of coronary sinus valve
created_by: dph
creation_date: 2009-10-08T11:33:31Z
[Term]
id: GO:0003183
name: mitral valve morphogenesis
def: "The process in which the structure of the mitral valve is generated and organized." [GOC:mtg_heart]
is_a: GO:0003181 ! atrioventricular valve morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002135 ! results in morphogenesis of mitral valve
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0003174 ! mitral valve development
relationship: RO:0002298 UBERON:0002135 ! results in morphogenesis of mitral valve
created_by: dph
creation_date: 2009-10-08T12:02:01Z
[Term]
id: GO:0003184
name: pulmonary valve morphogenesis
def: "The process in which the structure of the pulmonary valve is generated and organized." [GOC:mtg_heart]
is_a: GO:0003179 ! heart valve morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002146 ! results in morphogenesis of pulmonary valve
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0003177 ! pulmonary valve development
relationship: RO:0002298 UBERON:0002146 ! results in morphogenesis of pulmonary valve
created_by: dph
creation_date: 2009-10-08T12:03:35Z
[Term]
id: GO:0003185
name: sinoatrial valve morphogenesis
def: "The process in which the structure of the sinoatrial valve is generated and organized." [GOC:mtg_heart]
synonym: "SA valve morphogenesis" EXACT [GOC:mah]
is_a: GO:0003179 ! heart valve morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002086 ! results in morphogenesis of sinoatrial valve
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0003172 ! sinoatrial valve development
relationship: RO:0002298 UBERON:0002086 ! results in morphogenesis of sinoatrial valve
created_by: dph
creation_date: 2009-10-08T12:04:52Z
[Term]
id: GO:0003186
name: tricuspid valve morphogenesis
def: "The process in which the structure of the tricuspid valve is generated and organized." [GOC:mtg_heart]
is_a: GO:0003181 ! atrioventricular valve morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002134 ! results in morphogenesis of tricuspid valve
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0003175 ! tricuspid valve development
relationship: RO:0002298 UBERON:0002134 ! results in morphogenesis of tricuspid valve
created_by: dph
creation_date: 2009-10-08T12:05:45Z
[Term]
id: GO:0003187
name: ventriculo bulbo valve morphogenesis
def: "The process in which the structure of the ventriculo bulbo valve is generated and organized." [GOC:mtg_heart]
is_a: GO:0003179 ! heart valve morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0004149 ! results in morphogenesis of ventriculo bulbo valve
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0003173 ! ventriculo bulbo valve development
relationship: RO:0002298 UBERON:0004149 ! results in morphogenesis of ventriculo bulbo valve
created_by: dph
creation_date: 2009-10-08T12:07:00Z
[Term]
id: GO:0003188
name: heart valve formation
def: "The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0000946 ! results in formation of anatomical entity cardiac valve
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0003179 ! heart valve morphogenesis
relationship: RO:0002297 UBERON:0000946 ! results in formation of anatomical entity cardiac valve
created_by: dph
creation_date: 2009-10-08T12:20:15Z
[Term]
id: GO:0003189
name: aortic valve formation
def: "The developmental process pertaining to the initial formation of the aortic valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0003188 ! heart valve formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0002137 ! results in formation of anatomical entity aortic valve
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0003180 ! aortic valve morphogenesis
relationship: RO:0002297 UBERON:0002137 ! results in formation of anatomical entity aortic valve
created_by: dph
creation_date: 2009-10-08T01:05:44Z
[Term]
id: GO:0003190
name: atrioventricular valve formation
def: "The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
synonym: "AV valve formation" EXACT [GOC:mah]
is_a: GO:0003188 ! heart valve formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0002133 ! results in formation of anatomical entity atrioventricular valve
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0003181 ! atrioventricular valve morphogenesis
relationship: RO:0002297 UBERON:0002133 ! results in formation of anatomical entity atrioventricular valve
created_by: dph
creation_date: 2009-10-08T01:07:28Z
[Term]
id: GO:0003191
name: coronary sinus valve formation
def: "The developmental process pertaining to the initial formation of the coronary sinus valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0003188 ! heart valve formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0004150 ! results in formation of anatomical entity coronary sinus valve
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0003182 ! coronary sinus valve morphogenesis
relationship: RO:0002297 UBERON:0004150 ! results in formation of anatomical entity coronary sinus valve
created_by: dph
creation_date: 2009-10-08T01:09:04Z
[Term]
id: GO:0003192
name: mitral valve formation
def: "The developmental process pertaining to the initial formation of the mitral valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0003190 ! atrioventricular valve formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0002135 ! results in formation of anatomical entity mitral valve
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0003183 ! mitral valve morphogenesis
relationship: RO:0002297 UBERON:0002135 ! results in formation of anatomical entity mitral valve
created_by: dph
creation_date: 2009-10-08T01:10:19Z
[Term]
id: GO:0003193
name: pulmonary valve formation
def: "The developmental process pertaining to the initial formation of the pulmonary valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0003188 ! heart valve formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0002146 ! results in formation of anatomical entity pulmonary valve
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0003184 ! pulmonary valve morphogenesis
relationship: RO:0002297 UBERON:0002146 ! results in formation of anatomical entity pulmonary valve
created_by: dph
creation_date: 2009-10-08T01:11:20Z
[Term]
id: GO:0003194
name: sinoatrial valve formation
def: "The developmental process pertaining to the initial formation of the sinoatrial valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
synonym: "SA valve formation" EXACT [GOC:mah]
is_a: GO:0003188 ! heart valve formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0002086 ! results in formation of anatomical entity sinoatrial valve
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0003185 ! sinoatrial valve morphogenesis
relationship: RO:0002297 UBERON:0002086 ! results in formation of anatomical entity sinoatrial valve
created_by: dph
creation_date: 2009-10-08T01:12:45Z
[Term]
id: GO:0003195
name: tricuspid valve formation
def: "The developmental process pertaining to the initial formation of the tricuspid valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0003190 ! atrioventricular valve formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0002134 ! results in formation of anatomical entity tricuspid valve
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0003186 ! tricuspid valve morphogenesis
relationship: RO:0002297 UBERON:0002134 ! results in formation of anatomical entity tricuspid valve
created_by: dph
creation_date: 2009-10-08T01:14:40Z
[Term]
id: GO:0003196
name: ventriculo bulbo valve formation
def: "The developmental process pertaining to the initial formation of the ventriculo bulbo valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0003188 ! heart valve formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0004149 ! results in formation of anatomical entity ventriculo bulbo valve
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0003187 ! ventriculo bulbo valve morphogenesis
relationship: RO:0002297 UBERON:0004149 ! results in formation of anatomical entity ventriculo bulbo valve
created_by: dph
creation_date: 2009-10-08T01:16:02Z
[Term]
id: GO:0003197
name: endocardial cushion development
def: "The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart]
is_a: GO:0060485 ! mesenchyme development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002062 ! results in development of endocardial cushion
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0007507 ! heart development
relationship: RO:0002296 UBERON:0002062 ! results in development of endocardial cushion
created_by: dph
creation_date: 2009-10-08T01:17:43Z
[Term]
id: GO:0003203
name: endocardial cushion morphogenesis
def: "The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart]
is_a: GO:0072132 ! mesenchyme morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002062 ! results in morphogenesis of endocardial cushion
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0003197 ! endocardial cushion development
relationship: RO:0002298 UBERON:0002062 ! results in morphogenesis of endocardial cushion
created_by: dph
creation_date: 2009-10-08T01:43:22Z
[Term]
id: GO:0003204
name: cardiac skeleton development
def: "The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart." [GOC:mtg_heart]
synonym: "heart fibrous skeleton development" EXACT [GOC:mtg_heart]
is_a: GO:0061448 ! connective tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0004292 ! results in development of cardiac skeleton
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0007507 ! heart development
relationship: RO:0002296 UBERON:0004292 ! results in development of cardiac skeleton
created_by: dph
creation_date: 2009-10-13T09:05:04Z
[Term]
id: GO:0003205
name: cardiac chamber development
def: "The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0004151 ! results in development of cardiac chamber
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0007507 ! heart development
relationship: RO:0002296 UBERON:0004151 ! results in development of cardiac chamber
created_by: dph
creation_date: 2009-10-13T09:11:18Z
[Term]
id: GO:0003206
name: cardiac chamber morphogenesis
def: "The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart]
synonym: "heart chamber morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0004151 ! results in morphogenesis of cardiac chamber
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0003205 ! cardiac chamber development
relationship: RO:0002298 UBERON:0004151 ! results in morphogenesis of cardiac chamber
created_by: dph
creation_date: 2009-10-13T09:14:51Z
[Term]
id: GO:0003207
name: cardiac chamber formation
def: "The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart]
synonym: "heart chamber formation" EXACT [GOC:mtg_heart]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0004151 ! results in formation of anatomical entity cardiac chamber
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0003206 ! cardiac chamber morphogenesis
relationship: RO:0002297 UBERON:0004151 ! results in formation of anatomical entity cardiac chamber
created_by: dph
creation_date: 2009-10-13T09:29:13Z
[Term]
id: GO:0003208
name: cardiac ventricle morphogenesis
def: "The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart]
is_a: GO:0003206 ! cardiac chamber morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002082 ! results in morphogenesis of cardiac ventricle
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of GO:0003231 ! cardiac ventricle development
relationship: RO:0002298 UBERON:0002082 ! results in morphogenesis of cardiac ventricle
created_by: dph
creation_date: 2009-10-13T09:38:44Z
[Term]
id: GO:0003209
name: cardiac atrium morphogenesis
def: "The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart]
is_a: GO:0003206 ! cardiac chamber morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002081 ! results in morphogenesis of cardiac atrium
relationship: in_taxon NCBITaxon:7742 ! Vertebrata