format-version: 1.2 data-version: releases/2021-03-05 subsetdef: 3_STAR "" subsetdef: abnormal_slim "" subsetdef: absent_slim "" subsetdef: anatomical_site_slim "" subsetdef: attribute_slim "" subsetdef: cell_quality "" subsetdef: disposition_slim "" subsetdef: frequent_anatomy_items "" subsetdef: gocheck_do_not_annotate "" subsetdef: gocheck_do_not_manually_annotate "" subsetdef: goslim_agr "" subsetdef: goslim_aspergillus "" subsetdef: goslim_candida "" subsetdef: goslim_chembl "" subsetdef: goslim_drosophila "" subsetdef: goslim_flybase_ribbon "" subsetdef: goslim_generic "" subsetdef: goslim_metagenomics "" subsetdef: goslim_mouse "" subsetdef: goslim_pir "" subsetdef: goslim_plant "" subsetdef: goslim_pombe "" subsetdef: goslim_yeast "" subsetdef: hpo_slim "" subsetdef: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension "" subsetdef: http://purl.obolibrary.org/obo/valid_for_go_gp2term "" subsetdef: http://purl.obolibrary.org/obo/valid_for_go_ontology "" subsetdef: http://purl.obolibrary.org/obo/valid_for_gocam "" subsetdef: mpath_slim "" subsetdef: organism_views "" subsetdef: relational_slim "" subsetdef: ro-eco "" subsetdef: RO:0002259 "" subsetdef: scalar_slim "" subsetdef: sectional_anatomy_items "" subsetdef: upper_level "" subsetdef: value_slim "" ontology: xpo property_value: http://purl.org/dc/elements/1.1/description "XPO represents anatomical, cellular, and gene function phenotypes occurring throughout the development of the African frogs Xenopus laevis and tropicalis." xsd:string property_value: http://purl.org/dc/elements/1.1/title "Xenopus Phenotype Ontology" xsd:string property_value: http://purl.org/dc/terms/license https://creativecommons.org/licenses/by/3.0/ property_value: owl:versionInfo "2021-03-05" xsd:string [Term] id: BFO:0000001 name: entity property_value: BFO:0000179 "entity" xsd:string property_value: BFO:0000180 "Entity" xsd:string property_value: IAO:0000112 "Julius Caesar" xsd:string property_value: IAO:0000112 "the Second World War" xsd:string property_value: IAO:0000112 "Verdi’s Requiem" xsd:string property_value: IAO:0000112 "your body mass index" xsd:string property_value: IAO:0000116 "BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81" xsd:string property_value: IAO:0000116 "Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000004", comment="per discussion with Barry Smith", http://www.w3.org/2000/01/rdf-schema#seeAlso="http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf"} property_value: IAO:0000600 "An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/001-001"} property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000002 name: continuant def: "An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts." [] is_a: BFO:0000001 ! entity disjoint_from: BFO:0000003 ! occurrent relationship: part_of BFO:0000002 ! continuant property_value: BFO:0000179 "continuant" xsd:string property_value: BFO:0000180 "Continuant" xsd:string property_value: IAO:0000116 "BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240" xsd:string property_value: IAO:0000116 "Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000007"} property_value: IAO:0000600 "A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/008-002"} property_value: IAO:0000601 "if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/126-001"} property_value: IAO:0000601 "if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/009-002"} property_value: IAO:0000601 "if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/011-002"} property_value: IAO:0000602 "(forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/009-002"} property_value: IAO:0000602 "(forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/126-001"} property_value: IAO:0000602 "(forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/008-002"} property_value: IAO:0000602 "(forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/011-002"} property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000003 name: occurrent def: "An entity that has temporal parts and that happens, unfolds or develops through time." [] is_a: BFO:0000001 ! entity relationship: part_of BFO:0000003 ! occurrent property_value: BFO:0000179 "occurrent" xsd:string property_value: BFO:0000180 "Occurrent" xsd:string property_value: IAO:0000116 "BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region" xsd:string property_value: IAO:0000116 "BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players." xsd:string property_value: IAO:0000116 "Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process." xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000006", comment="per discussion with Barry Smith"} property_value: IAO:0000116 "Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame." xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000012"} property_value: IAO:0000600 "An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/077-002"} property_value: IAO:0000601 "b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/079-001"} property_value: IAO:0000601 "Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/108-001"} property_value: IAO:0000602 "(forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/108-001"} property_value: IAO:0000602 "(forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/079-001"} property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000004 name: independent continuant def: "A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything." [] def: "b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])" [] {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/017-002"} is_a: BFO:0000002 ! continuant disjoint_from: BFO:0000020 ! specifically dependent continuant disjoint_from: BFO:0000031 ! generically dependent continuant relationship: part_of BFO:0000004 ! independent continuant property_value: BFO:0000179 "ic" xsd:string property_value: BFO:0000180 "IndependentContinuant" xsd:string property_value: IAO:0000112 "a chair" xsd:string property_value: IAO:0000112 "a heart" xsd:string property_value: IAO:0000112 "a leg" xsd:string property_value: IAO:0000112 "a molecule" xsd:string property_value: IAO:0000112 "a spatial region" xsd:string property_value: IAO:0000112 "an atom" xsd:string property_value: IAO:0000112 "an orchestra." xsd:string property_value: IAO:0000112 "an organism" xsd:string property_value: IAO:0000112 "the bottom right portion of a human torso" xsd:string property_value: IAO:0000112 "the interior of your mouth" xsd:string property_value: IAO:0000601 "For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/134-001"} property_value: IAO:0000601 "For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/018-002"} property_value: IAO:0000602 "(forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/018-002"} property_value: IAO:0000602 "(forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/134-001"} property_value: IAO:0000602 "(iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/017-002"} property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000015 name: process def: "An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t." [] is_a: BFO:0000003 ! occurrent [Term] id: BFO:0000019 name: quality is_a: BFO:0000020 ! specifically dependent continuant relationship: part_of BFO:0000019 ! quality property_value: BFO:0000179 "quality" xsd:string property_value: BFO:0000180 "Quality" xsd:string property_value: IAO:0000112 "the ambient temperature of this portion of air" xsd:string property_value: IAO:0000112 "the color of a tomato" xsd:string property_value: IAO:0000112 "the length of the circumference of your waist" xsd:string property_value: IAO:0000112 "the mass of this piece of gold." xsd:string property_value: IAO:0000112 "the shape of your nose" xsd:string property_value: IAO:0000112 "the shape of your nostril" xsd:string property_value: IAO:0000600 "a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/055-001"} property_value: IAO:0000601 "If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/105-001"} property_value: IAO:0000602 "(forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/105-001"} property_value: IAO:0000602 "(forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/055-001"} property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000020 name: specifically dependent continuant def: "A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same." [] def: "b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])" [] {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/050-003"} is_a: BFO:0000002 ! continuant disjoint_from: BFO:0000031 ! generically dependent continuant relationship: part_of BFO:0000020 ! specifically dependent continuant property_value: BFO:0000179 "sdc" xsd:string property_value: BFO:0000180 "SpecificallyDependentContinuant" xsd:string property_value: IAO:0000112 "of one-sided specifically dependent continuants: the mass of this tomato" xsd:string property_value: IAO:0000112 "of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates." xsd:string property_value: IAO:0000112 "Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key" xsd:string property_value: IAO:0000112 "the disposition of this fish to decay" xsd:string property_value: IAO:0000112 "the function of this heart: to pump blood" xsd:string property_value: IAO:0000112 "the mutual dependence of proton donors and acceptors in chemical reactions [79" xsd:string property_value: IAO:0000112 "the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction" xsd:string property_value: IAO:0000112 "the pink color of a medium rare piece of grilled filet mignon at its center" xsd:string property_value: IAO:0000112 "the role of being a doctor" xsd:string property_value: IAO:0000112 "the shape of this hole." xsd:string property_value: IAO:0000112 "the smell of this portion of mozzarella" xsd:string property_value: IAO:0000116 "Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc." xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000005", comment="per discussion with Barry Smith"} property_value: IAO:0000602 "(iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/050-003"} property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000031 name: generically dependent continuant def: "A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time." [] def: "b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])" [] {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/074-001"} is_a: BFO:0000002 ! continuant property_value: BFO:0000179 "gdc" xsd:string property_value: BFO:0000180 "GenericallyDependentContinuant" xsd:string property_value: IAO:0000112 "The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity." xsd:string property_value: IAO:0000112 "the pdf file on your laptop, the pdf file that is a copy thereof on my laptop" xsd:string property_value: IAO:0000112 "the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule." xsd:string property_value: IAO:0000602 "(iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/074-001"} property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000040 name: material entity def: "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time." [] is_a: BFO:0000004 ! independent continuant disjoint_from: BFO:0000141 ! immaterial entity [Term] id: BFO:0000141 name: immaterial entity is_a: BFO:0000004 ! independent continuant [Term] id: CARO:0000000 name: anatomical entity is_a: CARO:0030000 ! biological entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/caro.owl [Term] id: CARO:0000003 name: connected anatomical structure is_a: CARO:0000006 ! material anatomical entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/caro.owl [Term] id: CARO:0000006 name: material anatomical entity is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/caro.owl [Term] id: CARO:0000007 name: immaterial anatomical entity is_a: BFO:0000141 ! immaterial entity [Term] id: CARO:0030000 name: biological entity is_a: BFO:0000004 ! independent continuant [Term] id: CHEBI:24431 name: chemical entity namespace: chebi_ontology def: "A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances." [] subset: 3_STAR synonym: "chemical entity" EXACT [UniProt] [Term] id: CL:0000000 name: cell is_a: CARO:0000003 ! connected anatomical structure property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl [Term] id: CL:0000540 name: neuron is_a: CL:0000000 ! cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl [Term] id: GO:0000003 name: reproduction namespace: biological_process alt_id: GO:0019952 alt_id: GO:0050876 def: "The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms." [GOC:go_curators, GOC:isa_complete, GOC:jl, ISBN:0198506732] subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_pir subset: goslim_plant synonym: "reproductive physiological process" EXACT [] xref: Wikipedia:Reproduction is_a: GO:0008150 ! biological_process [Term] id: GO:0000122 name: negative regulation of transcription by RNA polymerase II namespace: biological_process alt_id: GO:0010553 alt_id: GO:0045816 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] synonym: "down regulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "down regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "down-regulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "down-regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "downregulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "downregulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "inhibition of global transcription from RNA polymerase II promoter" RELATED [] synonym: "inhibition of transcription from RNA polymerase II promoter" EXACT [] synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [] synonym: "negative regulation of global transcription from Pol II promoter" RELATED [] synonym: "negative regulation of transcription from Pol II promoter" EXACT [] synonym: "negative regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "negative regulation of transcription from RNA polymerase II promoter, global" RELATED [] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0045892 ! negative regulation of transcription, DNA-templated intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006366 ! transcription by RNA polymerase II relationship: negatively_regulates GO:0006366 ! transcription by RNA polymerase II [Term] id: GO:0000165 name: MAPK cascade namespace: biological_process def: "An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:mtg_signaling_feb11, PMID:20811974, PMID:9561267] comment: MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier. synonym: "ERK/MAPK cascade" NARROW [] synonym: "MAP kinase cascade" EXACT [] synonym: "MAP kinase kinase kinase cascade" EXACT [] synonym: "MAPK signal transduction" EXACT [GOC:signaling] synonym: "MAPK signaling" RELATED [] synonym: "MAPK signalling" RELATED [] synonym: "MAPKKK cascade" EXACT [] synonym: "MAPKKK cascade during sporulation" NARROW [] synonym: "mitogen-activated protein kinase cascade" EXACT [GOC:bf] xref: Wikipedia:MAPK_cascade xref: Wikipedia:Mitogen-activated_protein_kinase is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0000212 name: meiotic spindle organization namespace: biological_process alt_id: GO:0043147 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle." [GOC:go_curators, GOC:mah] synonym: "meiotic spindle organisation" EXACT [] synonym: "meiotic spindle organization and biogenesis" RELATED [GOC:mah] synonym: "meiotic spindle stabilization" RELATED [] synonym: "spindle organization during meiosis" EXACT [GOC:mah] is_a: GO:0007051 ! spindle organization is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0007051 ! spindle organization intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0000226 name: microtubule cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] subset: goslim_drosophila subset: goslim_pombe synonym: "microtubule cytoskeleton organisation" EXACT [GOC:mah] synonym: "microtubule cytoskeleton organization and biogenesis" RELATED [GOC:mah] synonym: "microtubule dynamics" EXACT [GOC:dph, GOC:tb] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0007017 ! microtubule-based process [Term] id: GO:0000229 name: cytoplasmic chromosome namespace: cellular_component def: "A chromosome found in the cytoplasm." [GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "cytoplasmic interphase chromosome" NARROW [] is_a: GO:0005694 ! chromosome intersection_of: GO:0005694 ! chromosome intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0000278 name: mitotic cell cycle namespace: biological_process alt_id: GO:0007067 def: "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278] comment: Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_yeast synonym: "mitosis" RELATED [] xref: Wikipedia:Mitosis is_a: GO:0007049 ! cell cycle intersection_of: GO:0007049 ! cell cycle intersection_of: has_part GO:0140014 ! mitotic nuclear division relationship: has_part GO:0140014 ! mitotic nuclear division [Term] id: GO:0000280 name: nuclear division namespace: biological_process def: "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." [GOC:mah] subset: goslim_pir synonym: "karyokinesis" RELATED [] is_a: GO:0048285 ! organelle fission [Term] id: GO:0000281 name: mitotic cytokinesis namespace: biological_process def: "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] subset: goslim_pombe synonym: "cytokinesis after mitosis" EXACT [] is_a: GO:0061640 ! cytoskeleton-dependent cytokinesis is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0061640 ! cytoskeleton-dependent cytokinesis intersection_of: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0000785 name: chromatin namespace: cellular_component alt_id: GO:0000789 alt_id: GO:0000790 alt_id: GO:0005717 def: "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. synonym: "chromosome scaffold" RELATED [] synonym: "cytoplasmic chromatin" NARROW [] synonym: "nuclear chromatin" NARROW [] xref: NIF_Subcellular:sao1615953555 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005694 ! chromosome [Term] id: GO:0000902 name: cell morphogenesis namespace: biological_process alt_id: GO:0007148 alt_id: GO:0045790 alt_id: GO:0045791 def: "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_yeast synonym: "cellular morphogenesis" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0000904 name: cell morphogenesis involved in differentiation namespace: biological_process def: "The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:go_curators] is_a: GO:0000902 ! cell morphogenesis intersection_of: GO:0000902 ! cell morphogenesis intersection_of: part_of GO:0048468 ! cell development relationship: part_of GO:0048468 ! cell development [Term] id: GO:0000910 name: cytokinesis namespace: biological_process alt_id: GO:0007104 alt_id: GO:0016288 alt_id: GO:0033205 def: "The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. When annotating eukaryotic species, mitotic or meiotic cytokinesis should always be specified for manual annotation and for prokaryotic species use 'FtsZ-dependent cytokinesis ; GO:0043093' or Cdv-dependent cytokinesis ; GO:0061639. Also, note that cytokinesis does not necessarily result in physical separation and detachment of the two daughter cells from each other. subset: gocheck_do_not_manually_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_yeast synonym: "cell cycle cytokinesis" EXACT [] synonym: "cytokinesis involved in cell cycle" EXACT [GOC:dph, GOC:tb] xref: Wikipedia:Cytokinesis is_a: GO:0022402 ! cell cycle process relationship: has_part GO:0090148 ! membrane fission relationship: part_of GO:0051301 ! cell division [Term] id: GO:0001055 name: RNA polymerase II activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase II promoter" EXACT [] xref: Reactome:R-HSA-6814549 "Pre-snRNA transcript initiation, Integrator binding, LEC binding" xref: Reactome:R-HSA-6814559 "Pre-snRNA is elongated and capped with 7-methylguanosine" is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity intersection_of: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity intersection_of: part_of GO:0006366 ! transcription by RNA polymerase II relationship: occurs_in GO:0000785 ! chromatin relationship: part_of GO:0006366 ! transcription by RNA polymerase II created_by: krc creation_date: 2010-09-23T03:44:23Z [Term] id: GO:0001558 name: regulation of cell growth namespace: biological_process def: "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators] is_a: GO:0040008 ! regulation of growth is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016049 ! cell growth relationship: regulates GO:0016049 ! cell growth [Term] id: GO:0001578 name: microtubule bundle formation namespace: biological_process def: "A process that results in a parallel arrangement of microtubules." [GOC:dph] synonym: "microtubule bundling" EXACT [] is_a: GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0001667 name: ameboidal-type cell migration namespace: biological_process def: "Cell migration that is accomplished by extension and retraction of a pseudopodium." [GOC:dph] comment: Note that this term refers to a mode of migration rather than to any particular cell type. synonym: "ameboid cell migration" EXACT [] synonym: "amoeboid cell migration" EXACT [] synonym: "amoeboidal cell migration" EXACT [] is_a: GO:0016477 ! cell migration [Term] id: GO:0001704 name: formation of primary germ layer namespace: biological_process def: "The formation of the ectoderm, mesoderm and endoderm during gastrulation." [GOC:go_curators] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0007369 ! gastrulation [Term] id: GO:0001705 name: ectoderm formation namespace: biological_process def: "The formation of ectoderm during gastrulation." [GOC:go_curators] is_a: GO:0001704 ! formation of primary germ layer relationship: part_of GO:0007398 ! ectoderm development [Term] id: GO:0001706 name: endoderm formation namespace: biological_process def: "The formation of the endoderm during gastrulation." [GOC:go_curators] synonym: "endoblast formation" NARROW [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0001704 ! formation of primary germ layer relationship: part_of GO:0007492 ! endoderm development [Term] id: GO:0001707 name: mesoderm formation namespace: biological_process def: "The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:go_curators] is_a: GO:0001704 ! formation of primary germ layer relationship: part_of GO:0048332 ! mesoderm morphogenesis [Term] id: GO:0001736 name: establishment of planar polarity namespace: biological_process def: "Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph] synonym: "establishment of planar cell polarity" NARROW [] is_a: GO:0007164 ! establishment of tissue polarity relationship: part_of GO:0001738 ! morphogenesis of a polarized epithelium [Term] id: GO:0001738 name: morphogenesis of a polarized epithelium namespace: biological_process def: "The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:dph] synonym: "epithelial polarization" EXACT [GOC:dph] is_a: GO:0002009 ! morphogenesis of an epithelium [Term] id: GO:0001756 name: somitogenesis namespace: biological_process def: "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [ISBN:0721662544] synonym: "formation of mesodermal clusters" EXACT systematic_synonym [] xref: Wikipedia:Somitogenesis is_a: GO:0009952 ! anterior/posterior pattern specification is_a: GO:0035282 ! segmentation is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0043009 ! chordate embryonic development relationship: part_of GO:0061053 ! somite development [Term] id: GO:0001775 name: cell activation namespace: biological_process def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:mgi_curators] subset: goslim_pir is_a: GO:0009987 ! cellular process [Term] id: GO:0001838 name: embryonic epithelial tube formation namespace: biological_process def: "The morphogenesis of an embryonic epithelium into a tube-shaped structure." [GOC:dph, ISBN:0824072820] is_a: GO:0072175 ! epithelial tube formation relationship: part_of GO:0016331 ! morphogenesis of embryonic epithelium [Term] id: GO:0001839 name: neural plate morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue." [GOC:dph, ISBN:0878932437] is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0001840 ! neural plate development [Term] id: GO:0001840 name: neural plate development namespace: biological_process def: "The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GOC:dph, GOC:ef, ISBN:0878932437, ISBN:0878932585] is_a: GO:0060429 ! epithelium development relationship: part_of GO:0043009 ! chordate embryonic development [Term] id: GO:0001841 name: neural tube formation namespace: biological_process alt_id: GO:0001679 def: "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." [GOC:dph, ISBN:0878932437] synonym: "neural tube morphogenesis" EXACT [GOC:dph] synonym: "neurulation" EXACT [] xref: Wikipedia:Neurulation is_a: GO:0001838 ! embryonic epithelial tube formation relationship: part_of GO:0021915 ! neural tube development [Term] id: GO:0001843 name: neural tube closure namespace: biological_process def: "The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline." [GOC:dph, ISBN:0878932437] is_a: GO:0060606 ! tube closure relationship: part_of GO:0014020 ! primary neural tube formation [Term] id: GO:0001932 name: regulation of protein phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd] synonym: "regulation of protein amino acid phosphorylation" EXACT [GOC:bf] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0042325 ! regulation of phosphorylation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006468 ! protein phosphorylation relationship: regulates GO:0006468 ! protein phosphorylation [Term] id: GO:0001933 name: negative regulation of protein phosphorylation namespace: biological_process def: "Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein." [GOC:hjd] synonym: "down regulation of protein amino acid phosphorylation" EXACT [] synonym: "down-regulation of protein amino acid phosphorylation" EXACT [] synonym: "downregulation of protein amino acid phosphorylation" EXACT [] synonym: "inhibition of protein amino acid phosphorylation" NARROW [] synonym: "negative regulation of protein amino acid phosphorylation" EXACT [GOC:bf] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:0042326 ! negative regulation of phosphorylation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006468 ! protein phosphorylation relationship: negatively_regulates GO:0006468 ! protein phosphorylation [Term] id: GO:0001934 name: positive regulation of protein phosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd] synonym: "activation of protein amino acid phosphorylation" NARROW [] synonym: "positive regulation of protein amino acid phosphorylation" EXACT [GOC:bf] synonym: "stimulation of protein amino acid phosphorylation" NARROW [] synonym: "up regulation of protein amino acid phosphorylation" EXACT [] synonym: "up-regulation of protein amino acid phosphorylation" EXACT [] synonym: "upregulation of protein amino acid phosphorylation" EXACT [] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:0042327 ! positive regulation of phosphorylation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006468 ! protein phosphorylation relationship: positively_regulates GO:0006468 ! protein phosphorylation [Term] id: GO:0001947 name: heart looping namespace: biological_process def: "The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation." [GOC:dph, PMID:12094232] synonym: "cardiac looping" EXACT [] is_a: GO:0003143 ! embryonic heart tube morphogenesis relationship: part_of GO:0061371 ! determination of heart left/right asymmetry [Term] id: GO:0002009 name: morphogenesis of an epithelium namespace: biological_process def: "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732] synonym: "epithelium morphogenesis" EXACT [] is_a: GO:0048729 ! tissue morphogenesis relationship: part_of GO:0060429 ! epithelium development [Term] id: GO:0002011 name: morphogenesis of an epithelial sheet namespace: biological_process def: "The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells." [GOC:jl] is_a: GO:0002009 ! morphogenesis of an epithelium [Term] id: GO:0002064 name: epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0030855 ! epithelial cell differentiation [Term] id: GO:0002065 name: columnar/cuboidal epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0030855 ! epithelial cell differentiation [Term] id: GO:0002067 name: glandular epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation [Term] id: GO:0003002 name: regionalization namespace: biological_process def: "The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:isa_complete] synonym: "pattern formation" RELATED [GOC:dph] is_a: GO:0007389 ! pattern specification process [Term] id: GO:0003006 name: developmental process involved in reproduction namespace: biological_process def: "A developmental process in which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete] synonym: "puberty" NARROW [GOC:dph] synonym: "reproductive developmental process" RELATED [GOC:dph, GOC:tb] is_a: GO:0022414 ! reproductive process is_a: GO:0032502 ! developmental process intersection_of: GO:0032502 ! developmental process intersection_of: part_of GO:0000003 ! reproduction [Term] id: GO:0003007 name: heart morphogenesis namespace: biological_process def: "The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete] synonym: "cardiac morphogenesis" RELATED [] is_a: GO:0009887 ! animal organ morphogenesis relationship: part_of GO:0007507 ! heart development [Term] id: GO:0003008 name: system process namespace: biological_process def: "A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective." [GOC:mtg_cardio] synonym: "organ system process" EXACT [] is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0003013 name: circulatory system process namespace: biological_process def: "A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism." [GOC:mtg_cardio] subset: goslim_chembl subset: goslim_generic xref: Wikipedia:Circulatory_system is_a: GO:0003008 ! system process [Term] id: GO:0003015 name: heart process namespace: biological_process def: "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio] synonym: "cardiac process" RELATED [] is_a: GO:0003013 ! circulatory system process [Term] id: GO:0003127 name: detection of nodal flow namespace: biological_process def: "The series of events by which an endogenous stimulus is received by a cilium on a cell and converted to a molecular signal contributing to left/right asymmetry." [GOC:mtg_heart] is_a: GO:0009726 ! detection of endogenous stimulus relationship: part_of GO:0007368 ! determination of left/right symmetry created_by: tb creation_date: 2009-09-22T02:45:48Z [Term] id: GO:0003143 name: embryonic heart tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060562 ! epithelial tube morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0035050 ! embryonic heart tube development relationship: part_of GO:0048562 ! embryonic organ morphogenesis created_by: tb creation_date: 2009-09-22T04:21:17Z [Term] id: GO:0003154 name: BMP signaling pathway involved in determination of left/right symmetry namespace: biological_process def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the determination of left/right symmetry." [GOC:mtg_heart, GOC:signaling] synonym: "BMP signaling pathway involved in determination of left/right asymmetry" EXACT [GOC:dph] synonym: "BMP signalling pathway involved in determination of left/right symmetry" EXACT [GOC:mah] is_a: GO:0030509 ! BMP signaling pathway intersection_of: GO:0030509 ! BMP signaling pathway intersection_of: part_of GO:0007368 ! determination of left/right symmetry relationship: part_of GO:0007368 ! determination of left/right symmetry created_by: tb creation_date: 2009-09-24T05:34:57Z [Term] id: GO:0003241 name: growth involved in heart morphogenesis namespace: biological_process def: "Developmental growth that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0060560 ! developmental growth involved in morphogenesis intersection_of: GO:0040007 ! growth intersection_of: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0060419 ! heart growth created_by: dph creation_date: 2009-10-13T11:28:46Z [Term] id: GO:0003278 name: apoptotic process involved in heart morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of the heart." [GOC:mtg_apoptosis, GOC:mtg_heart] synonym: "apoptosis involved in heart morphogenesis" NARROW [] is_a: GO:0060561 ! apoptotic process involved in morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis created_by: dph creation_date: 2009-10-20T09:40:22Z [Term] id: GO:0003306 name: Wnt signaling pathway involved in heart development namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart] synonym: "Wnt receptor signaling pathway involved in heart development" EXACT [] synonym: "Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah] synonym: "Wnt-activated signaling pathway involved in heart development" EXACT [GOC:signaling] is_a: GO:0016055 ! Wnt signaling pathway is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development intersection_of: GO:0016055 ! Wnt signaling pathway intersection_of: part_of GO:0007507 ! heart development created_by: dph creation_date: 2009-10-22T12:26:07Z [Term] id: GO:0003307 name: regulation of Wnt signaling pathway involved in heart development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart] synonym: "regulation of Wnt receptor signaling pathway involved in heart development" EXACT [] synonym: "regulation of Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah] synonym: "regulation of Wnt-activated signaling pathway involved in heart development" EXACT [GOC:signaling] is_a: GO:0030111 ! regulation of Wnt signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0003306 ! Wnt signaling pathway involved in heart development relationship: regulates GO:0003306 ! Wnt signaling pathway involved in heart development created_by: dph creation_date: 2009-10-22T12:32:10Z [Term] id: GO:0003308 name: negative regulation of Wnt signaling pathway involved in heart development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart] synonym: "negative regulation of Wnt receptor signaling pathway involved in heart development" EXACT [] synonym: "negative regulation of Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah] synonym: "negative regulation of Wnt-activated signaling pathway involved in heart development" EXACT [GOC:signaling] is_a: GO:0003307 ! regulation of Wnt signaling pathway involved in heart development is_a: GO:0030178 ! negative regulation of Wnt signaling pathway is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0003306 ! Wnt signaling pathway involved in heart development relationship: negatively_regulates GO:0003306 ! Wnt signaling pathway involved in heart development created_by: dph creation_date: 2009-10-22T12:36:11Z [Term] id: GO:0003309 name: type B pancreatic cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph, PMID:11076772] synonym: "pancreatic B cell differentiation" EXACT [GOC:mah] synonym: "pancreatic beta cell differentiation" EXACT [GOC:dph] is_a: GO:0035883 ! enteroendocrine cell differentiation relationship: part_of GO:0031018 ! endocrine pancreas development created_by: dph creation_date: 2009-10-26T09:27:23Z [Term] id: GO:0003365 name: establishment of cell polarity involved in ameboidal cell migration namespace: biological_process def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030010 ! establishment of cell polarity intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: part_of GO:0001667 ! ameboidal-type cell migration relationship: part_of GO:0001667 ! ameboidal-type cell migration created_by: dph creation_date: 2009-12-08T04:50:41Z [Term] id: GO:0003379 name: establishment of cell polarity involved in gastrulation cell migration namespace: biological_process def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: part_of GO:0042074 ! cell migration involved in gastrulation relationship: part_of GO:0042074 ! cell migration involved in gastrulation created_by: dph creation_date: 2009-12-09T06:54:44Z [Term] id: GO:0003381 name: epithelial cell morphogenesis involved in gastrulation namespace: biological_process def: "The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003382 ! epithelial cell morphogenesis intersection_of: GO:0003382 ! epithelial cell morphogenesis intersection_of: part_of GO:0007369 ! gastrulation relationship: part_of GO:0007369 ! gastrulation created_by: dph creation_date: 2009-12-09T07:18:53Z [Term] id: GO:0003382 name: epithelial cell morphogenesis namespace: biological_process def: "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0002064 ! epithelial cell development created_by: dph creation_date: 2009-12-09T07:21:06Z [Term] id: GO:0003383 name: apical constriction namespace: biological_process def: "The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0070252 ! actin-mediated cell contraction relationship: part_of GO:0003382 ! epithelial cell morphogenesis created_by: dph creation_date: 2009-12-09T07:30:34Z [Term] id: GO:0003384 name: apical constriction involved in gastrulation namespace: biological_process def: "The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003383 ! apical constriction intersection_of: GO:0003383 ! apical constriction intersection_of: part_of GO:0007369 ! gastrulation relationship: part_of GO:0003381 ! epithelial cell morphogenesis involved in gastrulation created_by: dph creation_date: 2009-12-09T07:35:38Z [Term] id: GO:0003401 name: axis elongation namespace: biological_process def: "The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "elongation of an axis" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060560 ! developmental growth involved in morphogenesis created_by: dph creation_date: 2009-12-21T01:12:15Z [Term] id: GO:0003402 name: planar cell polarity pathway involved in axis elongation namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal to modulate cytoskeletal elements and control cell polarity that contributes to axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway intersection_of: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway intersection_of: part_of GO:0003401 ! axis elongation relationship: part_of GO:0003401 ! axis elongation created_by: dph creation_date: 2009-12-21T01:22:11Z [Term] id: GO:0003674 name: molecular_function namespace: molecular_function alt_id: GO:0005554 def: "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process." [GOC:pdt] comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "molecular function" EXACT [] is_a: BFO:0000015 ! process property_value: IAO:0000589 "molecular process" xsd:string [Term] id: GO:0003824 name: catalytic activity namespace: molecular_function def: "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "enzyme activity" EXACT [GOC:dph, GOC:tb] xref: Wikipedia:Enzyme is_a: GO:0003674 ! molecular_function [Term] id: GO:0003899 name: DNA-directed 5'-3' RNA polymerase activity namespace: molecular_function alt_id: GO:0000129 def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6, GOC:pf] synonym: "C ribonucleic acid formation factors" RELATED [EC:2.7.7.6] synonym: "C RNA formation factors" RELATED [EC:2.7.7.6] synonym: "deoxyribonucleic acid-dependent ribonucleic acid polymerase activity" RELATED [EC:2.7.7.6] synonym: "DNA-dependent ribonucleate nucleotidyltransferase activity" RELATED [EC:2.7.7.6] synonym: "DNA-dependent RNA nucleotidyltransferase activity" RELATED [EC:2.7.7.6] synonym: "DNA-dependent RNA polymerase activity" RELATED [EC:2.7.7.6] synonym: "DNA-directed RNA polymerase activity" BROAD [] synonym: "DNA-directed RNA polymerase I activity" NARROW [] synonym: "DNA-directed RNA polymerase II activity" NARROW [] synonym: "DNA-directed RNA polymerase III activity" NARROW [] synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) activity" RELATED [EC:2.7.7.6] synonym: "RNA nucleotidyltransferase (DNA-directed) activity" RELATED [EC:2.7.7.6] synonym: "RNA polymerase I activity" NARROW [EC:2.7.7.6] synonym: "RNA polymerase II activity" NARROW [EC:2.7.7.6] synonym: "RNA polymerase III activity" NARROW [EC:2.7.7.6] synonym: "transcriptase" BROAD [EC:2.7.7.6] xref: EC:2.7.7.6 xref: MetaCyc:DNA-DIRECTED-RNA-POLYMERASE-RXN xref: Reactome:R-HSA-111264 "Addition of nucleotides between position +11 and +30" xref: Reactome:R-HSA-167113 "Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition" xref: Reactome:R-HSA-167115 "Addition of nucleotides between position +11 and +30 on HIV-1 transcript" xref: Reactome:R-HSA-167117 "Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition" xref: Reactome:R-HSA-167121 "Addition of the third nucleotide on the nascent HIV-1 transcript" xref: Reactome:R-HSA-167136 "Addition of nucleotides 5 through 9 on the growing HIV-1 transcript" xref: Reactome:R-HSA-174425 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:R-HSA-203901 "Pol II mediated transcription of microRNA genes" xref: Reactome:R-HSA-427366 "Transcription of intergenic spacer of the rRNA gene" xref: Reactome:R-HSA-5601926 "RNA polymerase II polymerizes primary piRNA transcript" xref: Reactome:R-HSA-6781824 "Active RNA Pol II complex transcribes lesion-containing DNA template" xref: Reactome:R-HSA-68913 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin" xref: Reactome:R-HSA-74986 "Elongation of pre-rRNA transcript" xref: Reactome:R-HSA-75850 "Addition of the third nucleotide on the nascent transcript" xref: Reactome:R-HSA-75869 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition" xref: Reactome:R-HSA-75873 "Addition of Nucleotides 5 through 9 on the growing Transcript" xref: Reactome:R-HSA-76576 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition" xref: Reactome:R-HSA-9670149 "TERRA transcription" xref: Reactome:R-HSA-9697084 "Defective rpoB in Mtb RNAP transcribes RNA polyanion" xref: Reactome:R-HSA-9697085 "RNAP transcribes Mtb RNA polyanion" is_a: GO:0034062 ! 5'-3' RNA polymerase activity relationship: part_of GO:0032774 ! RNA biosynthetic process [Term] id: GO:0004175 name: endopeptidase activity namespace: molecular_function alt_id: GO:0016809 def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] synonym: "elastase activity" RELATED [GOC:krc] synonym: "endoprotease activity" NARROW [] synonym: "proteasome endopeptidase activity" NARROW [] synonym: "proteinase" NARROW [] xref: EC:3.4.99.- xref: MetaCyc:RXN0-5195 xref: Reactome:R-HSA-1168640 "Ubiquitinated IkB is degraded" xref: Reactome:R-HSA-1234159 "Proteasome proteolyzes ub-HIF-alpha" xref: Reactome:R-HSA-1236935 "Proteasomal cleavage of substrate" xref: Reactome:R-HSA-1236970 "Proteasomal clevage of exogenous antigen" xref: Reactome:R-HSA-1251997 "Cleavage of ERBB4m80 by gamma-scretase complex" xref: Reactome:R-HSA-1433374 "Processing of SCF isoform 1" xref: Reactome:R-HSA-1504193 "Ubiquitinated DVL is degraded by the proteasome" xref: Reactome:R-HSA-174058 "Degradation of multiubiquitinated Cdh1" xref: Reactome:R-HSA-174105 "Degradation of multiubiquitinated cell cycle proteins" xref: Reactome:R-HSA-174202 "Degradation of multiubiquitinated Securin" xref: Reactome:R-HSA-174203 "SCF-mediated degradation of Emi1" xref: Reactome:R-HSA-174255 "Degradation multiubiquitinated Cyclin A" xref: Reactome:R-HSA-180573 "Degradation of ubiquitinated CD4" xref: Reactome:R-HSA-180603 "Proteosome-mediated degradation of APOBEC3G" xref: Reactome:R-HSA-187574 "Degradation of ubiquitinated p27/p21 by the 26S proteasome" xref: Reactome:R-HSA-188191 "APC/C:Cdh1-mediated degradation of Skp2" xref: Reactome:R-HSA-193682 "gamma-secretase cleaves the p75NTR transmembrane domain" xref: Reactome:R-HSA-209061 "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex" xref: Reactome:R-HSA-211715 "Proteasome mediated degradation of PAK-2p34" xref: Reactome:R-HSA-2130282 "Degradation of ubiquitinated beta catenin by the proteasome" xref: Reactome:R-HSA-2213200 "Release of endostatin-like peptides" xref: Reactome:R-HSA-264458 "Proteasome mediated degradation of COP1" xref: Reactome:R-HSA-353125 "26S proteosome degrades ODC holoenzyme complex" xref: Reactome:R-HSA-3640874 "Ub-RibC-AXIN is degraded by the proteasome" xref: Reactome:R-HSA-3928656 "gamma-secretase cleaves EPHB2" xref: Reactome:R-HSA-450466 "AUF1:mRNA complex is destroyed" xref: Reactome:R-HSA-4608855 "PRICKLE1 is degraded by the proteasome" xref: Reactome:R-HSA-4641256 "Ubiquitinated AXIN is degraded by the proteasome" xref: Reactome:R-HSA-4641260 "Ubiquitinated DVL1 is degraded by the proteasome" xref: Reactome:R-HSA-5358340 "Autoproteolytic cleavage of Hh precursors" xref: Reactome:R-HSA-5358460 "HPE SHH variants don't undergo autoproteolytic cleavage" xref: Reactome:R-HSA-5362448 "Hh C-terminal fragments are degraded by the proteasome" xref: Reactome:R-HSA-5387392 "processing defective Hh variants are degraded by the proteasome" xref: Reactome:R-HSA-5607724 "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex" xref: Reactome:R-HSA-5607731 "26S proteasome processes p-7S-p100:RELB to form p52:RELB" xref: Reactome:R-HSA-5610754 "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor" xref: Reactome:R-HSA-5610757 "GLI2 is degraded by the proteasome" xref: Reactome:R-HSA-5610758 "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP" xref: Reactome:R-HSA-5610760 "GLI1 is degraded by the proteasome after ubiquitination by ITCH" xref: Reactome:R-HSA-5635854 "GLI2,3 are degraded by the proteasome" xref: Reactome:R-HSA-5635868 "ub-GLI is degraded by the proteasome" xref: Reactome:R-HSA-5658430 "NF1 is degraded by the proteasome" xref: Reactome:R-HSA-5668481 "Protesomal degradation of K48polyUb-TRAF3" xref: Reactome:R-HSA-5668520 "26Sproteasome degrades K48polyUb-NIK" xref: Reactome:R-HSA-5687112 "MAPK6 is degraded by the 26S proteasome" xref: Reactome:R-HSA-5693081 "FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501)" xref: Reactome:R-HSA-6784628 "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer" xref: Reactome:R-HSA-6784676 "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer" xref: Reactome:R-HSA-68825 "Ubiquitinated geminin is degraded by the proteasome" xref: Reactome:R-HSA-68948 "Ubiquitinated Orc1 is degraded by the proteasome" xref: Reactome:R-HSA-69016 "Ubiquitinated Cdc6 is degraded by the proteasome" xref: Reactome:R-HSA-69600 "Proteolytic degradation of ubiquitinated-Cdc25A" xref: Reactome:R-HSA-74730 "Insulin degradation" xref: Reactome:R-HSA-75825 "Proteasome mediated degradation of Cyclin D1" xref: Reactome:R-HSA-8849797 "Membrane proteases cleave Profilaggrin producing Filaggrin" xref: Reactome:R-HSA-8850992 "Proteasome degrades polyubiquitinated PTEN" xref: Reactome:R-HSA-8852354 "GTSE1 facilitates proteasome-mediated degradation of TP53" xref: Reactome:R-HSA-8854044 "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7" xref: Reactome:R-HSA-8854071 "Proteasome-mediated degradation of PolyUb-FBXL7" xref: Reactome:R-HSA-8866553 "misfolded CFTR is degraded by the 26S proteasome" xref: Reactome:R-HSA-8866858 "CFTR F508del is degraded by the 26S proteasome" xref: Reactome:R-HSA-8934819 "Cytoplasmic proteases cleave Profilaggrin producing Filaggrin" xref: Reactome:R-HSA-8939801 "26S proteasome degrades PolyUb-RUNX2" xref: Reactome:R-HSA-8952408 "Polyubiquitinated RUNX3 is degraded by the proteasome" xref: Reactome:R-HSA-8957265 "26S proteasome degrades TP73 polyubiquitinated by ITCH" xref: Reactome:R-HSA-9008110 "Proteasome degrades polyubiquitinated RUNX2" xref: Reactome:R-HSA-9008475 "Proteasome degrades polyubiquitinated RUNX2" xref: Reactome:R-HSA-9009362 "Proteasome degrades PolyUb-RUNX2" xref: Reactome:R-HSA-9010096 "Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)" xref: Reactome:R-HSA-9011313 "Proteasome degrades ubiquitinated ROBO3.1" xref: Reactome:R-HSA-9604642 "Proteasome degrades ubiquitinated NICD4" xref: Reactome:R-HSA-9614271 "Autocleavage of ADGRG6" xref: Reactome:R-HSA-983150 "Proteasomal cleavage of substrate" xref: Reactome:R-HSA-983158 "Trimming of peptides in ER" is_a: GO:0008233 ! peptidase activity [Term] id: GO:0004197 name: cysteine-type endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE] synonym: "caspase activity" NARROW [GOC:mtg_apoptosis] synonym: "lysosomal cysteine-type endopeptidase" NARROW [] synonym: "metacaspase activity" NARROW [GOC:mtg_apoptosis] synonym: "thiol endopeptidase activity" EXACT [] xref: EC:3.4.22.- xref: EC:3.4.22.1 xref: EC:3.4.22.14 xref: EC:3.4.22.15 xref: EC:3.4.22.16 xref: EC:3.4.22.27 xref: EC:3.4.22.28 xref: EC:3.4.22.34 xref: EC:3.4.22.38 xref: EC:3.4.22.40 xref: EC:3.4.22.41 xref: EC:3.4.22.8 xref: MetaCyc:3.4.22.1-RXN xref: MetaCyc:3.4.22.14-RXN xref: MetaCyc:3.4.22.15-RXN xref: MetaCyc:3.4.22.16-RXN xref: MetaCyc:3.4.22.27-RXN xref: MetaCyc:3.4.22.34-RXN xref: MetaCyc:3.4.22.38-RXN xref: MetaCyc:3.4.22.40-RXN xref: MetaCyc:3.4.22.41-RXN xref: Reactome:R-HSA-114252 "Cleavage of Procaspase-3 by the apoptosome" xref: Reactome:R-HSA-114259 "Cleavage of Procaspase9 to caspase9" xref: Reactome:R-HSA-114261 "Cleavage of Procaspase-7 by the apoptosome" xref: Reactome:R-HSA-1236948 "Antigen processing by cathepsin S in endosoytic vesicle" xref: Reactome:R-HSA-139898 "Caspase-8 activates BID by cleavage" xref: Reactome:R-HSA-139952 "Caspase-8 processing in the DISC" xref: Reactome:R-HSA-1678920 "TLR processing at low pH" xref: Reactome:R-HSA-1678981 "TLR9 processing at neutral pH" xref: Reactome:R-HSA-201595 "Caspase-mediated cleavage of plakophilin-1" xref: Reactome:R-HSA-201603 "Caspase-mediated cleavage of PKC theta" xref: Reactome:R-HSA-201608 "Caspase-mediated cleavage of alpha adducin" xref: Reactome:R-HSA-201611 "Caspase-mediated cleavage of Rock-1" xref: Reactome:R-HSA-201622 "Caspase-mediated cleavage of gelsolin" xref: Reactome:R-HSA-201628 "Caspase-mediated cleavage of vimentin at DSVD (85)" xref: Reactome:R-HSA-201629 "Caspase-mediated cleavage of Tau" xref: Reactome:R-HSA-201630 "Caspase-mediated cleavage of Acinus" xref: Reactome:R-HSA-201631 "Caspase-mediated cleavage of Desmoglein 3" xref: Reactome:R-HSA-201634 "Caspase-mediated cleavage of FADK 1" xref: Reactome:R-HSA-201636 "Caspase-mediated cleavage of Desmoplakin" xref: Reactome:R-HSA-201637 "Caspase-mediated cleavage of plectin-1" xref: Reactome:R-HSA-201639 "Caspase-mediated cleavage of GAS2" xref: Reactome:R-HSA-201640 "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha" xref: Reactome:R-HSA-2028692 "Cleavage of p-STK4 (p-MST1) by caspase 3" xref: Reactome:R-HSA-2028697 "Cleavage of p-STK3 (p-MST2) by caspase 3" xref: Reactome:R-HSA-202917 "Caspase-mediated cleavage of Desmoglein 1" xref: Reactome:R-HSA-202939 "Caspase-mediated cleavage of E-Cadherin" xref: Reactome:R-HSA-202947 "Caspase mediated cleavage of APC" xref: Reactome:R-HSA-202960 "Caspase mediated cleavage of C-IAP1" xref: Reactome:R-HSA-202966 "Caspase mediated cleavage of HIP-55" xref: Reactome:R-HSA-202967 "Caspase mediated cleavage of alpha-II-Fodrin" xref: Reactome:R-HSA-202969 "Caspase mediated cleavage of beta-catenin" xref: Reactome:R-HSA-211186 "Cleavage of DFF45 (224) by caspase-3" xref: Reactome:R-HSA-211190 "Caspase 3-mediated cleavage of DFF45 (117)" xref: Reactome:R-HSA-211651 "Cleavage of PAK-2 at 212" xref: Reactome:R-HSA-212552 "Caspase 3-mediated cleavage of PKC delta" xref: Reactome:R-HSA-2130336 "Initial proteolyis of Ii by aspartic proteases to lip22" xref: Reactome:R-HSA-2130349 "Generation of CLIP from lip10" xref: Reactome:R-HSA-2130504 "Cleavage of lip22 to lip10" xref: Reactome:R-HSA-2130706 "MHC class II antigen processing" xref: Reactome:R-HSA-2562564 "Caspase-8 processing within TLR4 complex" xref: Reactome:R-HSA-264865 "Caspase-mediated cleavage of Lamin A" xref: Reactome:R-HSA-264871 "Caspase-mediated cleavage of Lamin B1" xref: Reactome:R-HSA-3465448 "Caspase-8 and FLIP(L) processing at DISC" xref: Reactome:R-HSA-350158 "LGMN degrades GC" xref: Reactome:R-HSA-350318 "Caspase-mediated cleavage of vimentin at TNLD (429)" xref: Reactome:R-HSA-350319 "Caspase mediated cleavage of vimentin at IDVD (259)" xref: Reactome:R-HSA-350651 "Caspase-mediated cleavage of MASK" xref: Reactome:R-HSA-351849 "Caspase-mediated cleavage of Etk" xref: Reactome:R-HSA-351871 "Caspase-mediated cleavage of Z0-2" xref: Reactome:R-HSA-351876 "Caspase-mediated cleavage of occludin" xref: Reactome:R-HSA-351877 "Caspase-mediated cleavage of Desmoglein 2" xref: Reactome:R-HSA-351894 "Caspase mediated cleavage of BAP31" xref: Reactome:R-HSA-351901 "Caspase-mediated cleavage of MST3" xref: Reactome:R-HSA-351913 "Caspase-mediated cleavage of TJP1" xref: Reactome:R-HSA-351936 "Caspase-mediated cleavage of claspin" xref: Reactome:R-HSA-352268 "Cleavage of Satb1" xref: Reactome:R-HSA-418845 "Activation of caspase-3" xref: Reactome:R-HSA-418846 "Caspase cleavage of UNC5A" xref: Reactome:R-HSA-418852 "Caspase cleavage of UNC5B" xref: Reactome:R-HSA-448703 "Interleukin-1 family precursors are cleaved by caspase-1" xref: Reactome:R-HSA-5357828 "RIPK1 is cleaved by CASP8" xref: Reactome:R-HSA-5634228 "TRAF1 is cleaved by caspases" xref: Reactome:R-HSA-5660663 "Caspase-8 cleaves IL1B precursor" xref: Reactome:R-HSA-5681987 "LC3 is cleaved by ATG4" xref: Reactome:R-HSA-5682377 "LC3 de-lipidation by ATG4" xref: Reactome:R-HSA-6814387 "CASP14 cleaves filaggrin" xref: Reactome:R-HSA-9012556 "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37" xref: Reactome:R-HSA-9013895 "Caspase-8 processing within TLR3 complex" xref: Reactome:R-HSA-933532 "Processing of caspases" xref: Reactome:R-HSA-9603534 "Unknown caspase cleaves NTRK3" xref: Reactome:R-HSA-9647999 "RCE1 cleaves S-Farn proRAS proteins" xref: Reactome:R-HSA-9684273 "3CLp cleaves pp1a" xref: Reactome:R-HSA-9684309 "3CLp cleaves nsp6-11" xref: Reactome:R-HSA-9684321 "nsp3 cleaves nsp1-4" xref: Reactome:R-HSA-9684336 "nsp1-4 cleaves itself" xref: Reactome:R-HSA-9684340 "3CLp cleaves pp1ab" xref: Reactome:R-HSA-9684351 "pp1a cleaves itself" xref: Reactome:R-HSA-9684352 "nsp3-4 cleaves itself" xref: Reactome:R-HSA-9686930 "RIPK3 is cleaved by CASP8" xref: Reactome:R-HSA-9693929 "RIPK1 variant is not cleaved by CASP8" xref: Reactome:R-HSA-9694338 "nsp1-4 cleaves itself" xref: Reactome:R-HSA-9694377 "pp1a cleaves itself" xref: Reactome:R-HSA-9694441 "3CLp cleaves pp1a" xref: Reactome:R-HSA-9694551 "3CLp cleaves nsp6-11" xref: Reactome:R-HSA-9694601 "nsp3-4 cleaves itself" xref: Reactome:R-HSA-9694625 "nsp3 cleaves nsp1-4" xref: Reactome:R-HSA-9694732 "3CLp cleaves pp1ab" xref: Reactome:R-HSA-9697750 "RIPK1 is cleaved by CASP8:FLIP(L)" is_a: GO:0004175 ! endopeptidase activity is_a: GO:0008234 ! cysteine-type peptidase activity [Term] id: GO:0004672 name: protein kinase activity namespace: molecular_function alt_id: GO:0050222 def: "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] comment: Note that triphosphate is used as a phosphate donor by at least one kinase. subset: goslim_aspergillus subset: goslim_candida synonym: "protamine kinase activity" NARROW [] xref: MetaCyc:PROTEIN-KINASE-RXN xref: Reactome:R-HSA-156832 "INF-gamma induced phosphorylation of L13a" xref: Reactome:R-HSA-937034 "IRAK1 phosphorylates Pellino" xref: Reactome:R-HSA-9604606 "Unknown kinase phosphorylates NICD4" xref: Reactome:R-HSA-9673284 "GTP-bound RAC1 contributes to MAPK8 activation" xref: Reactome:R-HSA-975139 "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation" is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0140096 ! catalytic activity, acting on a protein relationship: part_of GO:0006468 ! protein phosphorylation [Term] id: GO:0004674 name: protein serine/threonine kinase activity namespace: molecular_function alt_id: GO:0004695 alt_id: GO:0004696 alt_id: GO:0004700 def: "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, PMID:2956925] synonym: "protein kinase (phosphorylating) activity" NARROW [EC:2.7.11.1] synonym: "protein phosphokinase activity" NARROW [EC:2.7.11.1] synonym: "protein serine kinase activity" NARROW [EC:2.7.11.1] synonym: "protein serine-threonine kinase activity" RELATED [EC:2.7.11.1] synonym: "protein-serine kinase activity" NARROW [EC:2.7.11.1] synonym: "serine kinase activity" NARROW [EC:2.7.11.1] synonym: "serine protein kinase activity" NARROW [EC:2.7.11.1] synonym: "serine(threonine) protein kinase activity" RELATED [EC:2.7.11.1] synonym: "serine-specific protein kinase activity" NARROW [EC:2.7.11.1] synonym: "serine/threonine protein kinase activity" RELATED [EC:2.7.11.1] synonym: "threonine-specific protein kinase activity" NARROW [EC:2.7.11.1] xref: EC:2.7.11.- xref: Reactome:R-HSA-109702 "PDPK1 phosphorylates AKT2" xref: Reactome:R-HSA-109822 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1" xref: Reactome:R-HSA-109823 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2" xref: Reactome:R-HSA-109860 "MAP2K1 phosphorylates MAPK3" xref: Reactome:R-HSA-109862 "MAP2K2 phosphorylates MAPK1" xref: Reactome:R-HSA-111919 "PKA phosphorylates CREB1" xref: Reactome:R-HSA-111970 "PKC phosphorylates GRK2" xref: Reactome:R-HSA-112342 "Inactivation of MAP2K1 by CDK1" xref: Reactome:R-HSA-112381 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex" xref: Reactome:R-HSA-1168635 "PRKCB (PKC-beta) phosphorylates CARMA1" xref: Reactome:R-HSA-1168638 "Activated IKK phosphorylates I-kappaB" xref: Reactome:R-HSA-1168641 "TAK1 associated with the CBM complex phosphorylates IKKbeta" xref: Reactome:R-HSA-1181149 "ACVR2A/B (ActRIIA/B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin" xref: Reactome:R-HSA-1181156 "Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL" xref: Reactome:R-HSA-1181355 "Phosphorylation of R-SMAD2/3 by NODAL receptor" xref: Reactome:R-HSA-1225894 "Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL" xref: Reactome:R-HSA-1358791 "Phosphorylation of USP8 by P-AKT" xref: Reactome:R-HSA-1362270 "Phosphorylation of LIN52 component of MuvB by DYRK1A" xref: Reactome:R-HSA-139908 "Phosphorylation of DLC2 by MAPK8" xref: Reactome:R-HSA-139918 "Phosphorylation of BIM by JNK" xref: Reactome:R-HSA-1445144 "p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)" xref: Reactome:R-HSA-1449597 "p-AKT2 phosphorylates Myosin 5A" xref: Reactome:R-HSA-1454699 "AMPK-alpha2 phosphorylates TBC1D1" xref: Reactome:R-HSA-1458463 "p-AKT2 phosphorylates RGC2" xref: Reactome:R-HSA-1549526 "Phosphorylation of SMAD2/3 by Activin:Activin Receptor" xref: Reactome:R-HSA-156673 "Regulation of KIF23 (MKLP1) by phosphorylation" xref: Reactome:R-HSA-156678 "Activation of Cdc25C" xref: Reactome:R-HSA-156682 "PLK1 phosphorylates NUDC" xref: Reactome:R-HSA-156699 "Inactivation of Wee1 kinase" xref: Reactome:R-HSA-156723 "Regulation of KIF20A (MKL2) by phosphorylation" xref: Reactome:R-HSA-1592233 "p38 MAPK phosphorylates PPARGC1A" xref: Reactome:R-HSA-162363 "p-T309,S474-AKT2:PIP3 phosphorylates PDE3B" xref: Reactome:R-HSA-162657 "Inactivation of Myt1 kinase" xref: Reactome:R-HSA-163010 "Down Regulation of Emi1 through Phosphorylation of Emi1" xref: Reactome:R-HSA-1632857 "ULK1 phosphorylates AMBRA1:BECN1 complex" xref: Reactome:R-HSA-163416 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP" xref: Reactome:R-HSA-163418 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP" xref: Reactome:R-HSA-1638803 "Phosphorylation of cohesin by PLK1 at centromeres" xref: Reactome:R-HSA-164151 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer" xref: Reactome:R-HSA-165162 "Phosphorylation of TSC2 by PKB" xref: Reactome:R-HSA-165182 "Phosphorylation of complexed TSC2 by PKB" xref: Reactome:R-HSA-165692 "Phosphorylation of 4E-BP1 by activated mTORC1" xref: Reactome:R-HSA-165718 "mTORC1 phosphorylation of RPS6KB1 (S6K)" xref: Reactome:R-HSA-165726 "Phosphorylation of Ribosomal protein S6 by activated S6K1" xref: Reactome:R-HSA-165758 "Phosphorylation and inactivation of eEF2K by activated S6K1" xref: Reactome:R-HSA-165766 "Phosphorylation and activation of eIF4G by activated S6K1" xref: Reactome:R-HSA-165777 "Phosphorylation and activation of eIF4B by activated S6K1" xref: Reactome:R-HSA-166119 "First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal" xref: Reactome:R-HSA-166245 "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex" xref: Reactome:R-HSA-166284 "Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP" xref: Reactome:R-HSA-166286 "Multiple IRAK1 autophosphorylation steps" xref: Reactome:R-HSA-167084 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex" xref: Reactome:R-HSA-167098 "Phosphorylation (Ser5) of RNA pol II CTD" xref: Reactome:R-HSA-168053 "Phosphorylated MAPKs phosphorylate ATF-2" xref: Reactome:R-HSA-168140 "Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex" xref: Reactome:R-HSA-170055 "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes" xref: Reactome:R-HSA-170076 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes" xref: Reactome:R-HSA-170087 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes" xref: Reactome:R-HSA-170116 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2" xref: Reactome:R-HSA-170126 "Phosphorylation of Cyclin B1 in the CRS domain" xref: Reactome:R-HSA-170977 "FRS2 is phosphorylated by active TrkA receptor" xref: Reactome:R-HSA-174119 "Free APC/C phosphorylated by Plk1" xref: Reactome:R-HSA-174174 "Phosphorylation of the Emi1 DSGxxS degron by Plk1" xref: Reactome:R-HSA-176116 "Recruitment and activation of Chk1" xref: Reactome:R-HSA-176298 "Activation of claspin" xref: Reactome:R-HSA-187688 "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3" xref: Reactome:R-HSA-187949 "CAK-mediated phosphorylation of Cyclin A:Cdk2" xref: Reactome:R-HSA-188350 "CAK-mediated phosphorylation of Cyclin E:Cdk2" xref: Reactome:R-HSA-193647 "IRAK is activated" xref: Reactome:R-HSA-193705 "IKKbeta phosphorylates IkB causing NF-kB to dissociate" xref: Reactome:R-HSA-195275 "Phosphorylation of APC component of the destruction complex" xref: Reactome:R-HSA-195283 "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3" xref: Reactome:R-HSA-195287 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3" xref: Reactome:R-HSA-195300 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3" xref: Reactome:R-HSA-195318 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha" xref: Reactome:R-HSA-198270 "PDPK1 phosphorylates AKT at T308" xref: Reactome:R-HSA-198347 "AKT phosphorylates BAD" xref: Reactome:R-HSA-198371 "AKT phosphorylates GSK3" xref: Reactome:R-HSA-198599 "AKT phosphorylates MDM2" xref: Reactome:R-HSA-198609 "AKT phosphorylates TSC2, inhibiting it" xref: Reactome:R-HSA-198611 "AKT phosphorylates IKKalpha" xref: Reactome:R-HSA-198613 "AKT phosphorylates p21Cip1 and p27Kip1" xref: Reactome:R-HSA-198621 "AKT phosphorylates caspase-9" xref: Reactome:R-HSA-198640 "TORC2 (mTOR) phosphorylates AKT at S473" xref: Reactome:R-HSA-198669 "p38MAPK phosphorylates MSK1" xref: Reactome:R-HSA-198731 "ERK1/2 activates ELK1" xref: Reactome:R-HSA-198746 "ERK1/2/5 activate RSK1/2/3" xref: Reactome:R-HSA-198756 "ERK1/2 phosphorylates MSK1" xref: Reactome:R-HSA-199298 "AKT phosphorylates CREB1" xref: Reactome:R-HSA-199299 "AKT phosphorylates FOXO transcription factors" xref: Reactome:R-HSA-199839 "AKT can phosphorylate RSK" xref: Reactome:R-HSA-199863 "AKT can phosphorylate NR4A1 (NUR77)" xref: Reactome:R-HSA-199895 "RSK1/2/3 phosphorylates CREB at Serine 133" xref: Reactome:R-HSA-199910 "MSK1 activates ATF1" xref: Reactome:R-HSA-199917 "MAPKAPK2 phosphorylates CREB at Serine 133" xref: Reactome:R-HSA-199929 "ERK5 activates the transcription factor MEF2" xref: Reactome:R-HSA-199935 "MSK1 activates CREB" xref: Reactome:R-HSA-200143 "AKT phosphorylates AKT1S1 (PRAS40)" xref: Reactome:R-HSA-200421 "Activation of cytosolic AMPK by phosphorylation" xref: Reactome:R-HSA-201677 "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta" xref: Reactome:R-HSA-201691 "Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI" xref: Reactome:R-HSA-201717 "CSNK2-mediated phosphorylation of DVL" xref: Reactome:R-HSA-202222 "Phosphorylation of PKC theta" xref: Reactome:R-HSA-202437 "Phosphorylation of CARMA1" xref: Reactome:R-HSA-202459 "Phosphorylation of Bcl10" xref: Reactome:R-HSA-202500 "Activation of IKK complex" xref: Reactome:R-HSA-202510 "Activation of TAK1-TAB2 complex" xref: Reactome:R-HSA-202541 "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB" xref: Reactome:R-HSA-2028284 "Phosphorylation of STK4 (MST1) and SAV1 by STK4" xref: Reactome:R-HSA-2028555 "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)" xref: Reactome:R-HSA-2028583 "Phosphorylation of YAP by LATS2" xref: Reactome:R-HSA-2028589 "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)" xref: Reactome:R-HSA-2028591 "Phosphorylation of STK3 (MST2) and SAV1 by STK3" xref: Reactome:R-HSA-2028598 "Phosphorylation of YAP by LATS1" xref: Reactome:R-HSA-2028629 "Phosphorylation of MOB1A and B by p-STK4 (p-MST1)" xref: Reactome:R-HSA-2028635 "Phosphorylation of MOB1A and B by p-STK3 (p-MST2)" xref: Reactome:R-HSA-2028661 "Phosphorylation of WWTR1 (TAZ) by LATS2" xref: Reactome:R-HSA-2028670 "Phosphorylation of MOB1A and B by p-STK4(MST1)/N" xref: Reactome:R-HSA-2028673 "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N" xref: Reactome:R-HSA-2028675 "Phosphorylation of MOB1A and B by p-STK3(MST2)/N" xref: Reactome:R-HSA-2028679 "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N" xref: Reactome:R-HSA-2029454 "Autophosphorylation of PAK1" xref: Reactome:R-HSA-2029460 "PAK1 phosphorylates LIMK1" xref: Reactome:R-HSA-2029469 "p-ERK phosphorylates WAVEs and ABI" xref: Reactome:R-HSA-2060328 "Phosphorylation of WWTR1 (TAZ) by LATS1" xref: Reactome:R-HSA-209087 "IKBA is phosphorylated by Phospho IKKB kinase" xref: Reactome:R-HSA-211164 "AKT phosphorylates FOXO1A" xref: Reactome:R-HSA-211583 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197" xref: Reactome:R-HSA-211650 "Autophosphorylation of PAK-2p34 in the activation loop" xref: Reactome:R-HSA-2168079 "MASTL (GWL) phosphorylates ARPP19" xref: Reactome:R-HSA-2176475 "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9" xref: Reactome:R-HSA-2214351 "PLK1 phosphorylates GORASP1" xref: Reactome:R-HSA-2243938 "AKT1 E17K mutant is phosphorylated by TORC2 complex" xref: Reactome:R-HSA-2243942 "PDPK1 phosphorylates AKT1 E17K mutant" xref: Reactome:R-HSA-2294580 "PLK1 hyperphosphorylates Condensin II complex" xref: Reactome:R-HSA-2396007 "IRF3 is phosphorylated by TBK1" xref: Reactome:R-HSA-2399941 "AKT1 E17K mutant phosphorylates BAD" xref: Reactome:R-HSA-2399966 "AKT1 E17K mutant phosphorylates GSK3" xref: Reactome:R-HSA-2399969 "AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1" xref: Reactome:R-HSA-2399977 "AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)" xref: Reactome:R-HSA-2399981 "AKT1 E17K mutant phosphorylates MDM2" xref: Reactome:R-HSA-2399982 "AKT1 E17K mutant phosphorylates TSC2, inhibiting it" xref: Reactome:R-HSA-2399985 "AKT1 E17K mutant phosphorylates caspase-9" xref: Reactome:R-HSA-2399988 "AKT1 E17K mutant phosphorylates NR4A1 (NUR77)" xref: Reactome:R-HSA-2399992 "AKT1 E17K mutant phosphorylates forkhead box transcription factors" xref: Reactome:R-HSA-2399996 "AKT1 E17K mutant phosphorylates CREB1" xref: Reactome:R-HSA-2399999 "AKT1 E17K mutant phosphorylates RSK" xref: Reactome:R-HSA-2400001 "AKT1 E17K mutant phosphorylates CHUK (IKKalpha)" xref: Reactome:R-HSA-2422927 "MAPK3-3 or MAPK1 phosphorylate GORASP2" xref: Reactome:R-HSA-2430535 "MASTL phosphorylates ENSA" xref: Reactome:R-HSA-2466068 "Phosphorylation of cohesin by PLK1 at chromosomal arms" xref: Reactome:R-HSA-2470508 "ACVR2A/B (ActRIIA/B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin" xref: Reactome:R-HSA-2529020 "CK2 phosphorylates condensin I subunits" xref: Reactome:R-HSA-2562526 "PLK1 phosphorylates OPTN" xref: Reactome:R-HSA-2574840 "AJUBA facilitates AURKA autophosphorylation" xref: Reactome:R-HSA-2730856 "Autophosphorylation of PAK" xref: Reactome:R-HSA-2730868 "Phosphorylation of MEK7 by MEKK1" xref: Reactome:R-HSA-2730876 "Phosphorylation of IKK-beta by TAK1" xref: Reactome:R-HSA-2730896 "Phosphorylation of MEK4 by MEKK1" xref: Reactome:R-HSA-2730900 "Activation of TAK1 complex bound to pUb-TRAF6" xref: Reactome:R-HSA-2984226 "PLK1 phosphorylates NEK9" xref: Reactome:R-HSA-2984258 "NEK9 phosphorylates NEK6/NEK7" xref: Reactome:R-HSA-2990880 "NEK6/NEK7 phosphorylates NUP98" xref: Reactome:R-HSA-2993898 "VRK1/VRK2 phosphorylate BANF1" xref: Reactome:R-HSA-3000310 "AURKA phosphorylates PLK1" xref: Reactome:R-HSA-3000327 "PLK1 phosphorylates BORA" xref: Reactome:R-HSA-3132737 "MAPKs phosphorylate ETS1 and ETS2" xref: Reactome:R-HSA-3209160 "Activated ERKs phosphorylate ERF" xref: Reactome:R-HSA-3222006 "STK11 (LKB1) phosphorylates NUAK1" xref: Reactome:R-HSA-3222020 "NUAK1 phosphorylates TP53" xref: Reactome:R-HSA-3228469 "MAP3K5 phosphorylates MKK3 and MKK6" xref: Reactome:R-HSA-3229102 "p-MAPKAPK3 phosphorylates BMI1" xref: Reactome:R-HSA-3229152 "MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)" xref: Reactome:R-HSA-3239014 "MAPKAPK5 phosphorylates TP53" xref: Reactome:R-HSA-3239019 "Active p38 MAPK phosphorylates MAPKAPK5" xref: Reactome:R-HSA-3249371 "TBK1 phosphorylates STAT6 at Ser407" xref: Reactome:R-HSA-3371435 "Constitutive phosphorylation by GSK3" xref: Reactome:R-HSA-3371531 "Constitutive phosphorylation by pERK1/2" xref: Reactome:R-HSA-3371567 "DBC1 is phosphorylated by ATM/ART" xref: Reactome:R-HSA-349426 "Phosphorylation of MDM4 by CHEK2" xref: Reactome:R-HSA-349444 "Phosphorylation of COP1 at Ser-387 by ATM" xref: Reactome:R-HSA-349455 "Phosphorylation of MDM4 by ATM" xref: Reactome:R-HSA-374696 "Phosphorylation of L1 by p90rsk" xref: Reactome:R-HSA-3769394 "AKT phosphorylates CBY1" xref: Reactome:R-HSA-377186 "Activated Akt1 phosphorylates AKT1S1 (PRAS40)" xref: Reactome:R-HSA-3772435 "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL" xref: Reactome:R-HSA-380272 "Plk1-mediated phosphorylation of Nlp" xref: Reactome:R-HSA-381091 "IRE1 dimer autophosphorylates" xref: Reactome:R-HSA-381111 "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK" xref: Reactome:R-HSA-3857328 "RPS6KA1/2/3 phosphorylates CEBPB on S321" xref: Reactome:R-HSA-3857329 "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB" xref: Reactome:R-HSA-3858480 "WNT-dependent phosphorylation of DVL" xref: Reactome:R-HSA-389756 "AKT interacts and phosphorylates Cot" xref: Reactome:R-HSA-392752 "Phosphorylation of L1 by CK-II" xref: Reactome:R-HSA-3928577 "ROCK phosphorylates LIMK1,2" xref: Reactome:R-HSA-3928608 "LIMK phosphorylates CFL1, inactivating it" xref: Reactome:R-HSA-3928616 "Activated ROCK phosphorylates MRLCs" xref: Reactome:R-HSA-3928620 "PAK1 autophosphorylates" xref: Reactome:R-HSA-3928625 "PAKs autophosphorylate" xref: Reactome:R-HSA-3928640 "PAKs phosphorylate MLC" xref: Reactome:R-HSA-399939 "Autophosphorylation of PAK" xref: Reactome:R-HSA-399944 "Phosphorylation of CRMPs by Cdk5" xref: Reactome:R-HSA-399950 "Phosphorylation of cofilin by LIMK-1" xref: Reactome:R-HSA-399951 "Phosphorylation of CRMPs by GSK3beta" xref: Reactome:R-HSA-399952 "Phosphorylation of LIMK-1 by PAK" xref: Reactome:R-HSA-399978 "Protein kinase C, alpha type phosphorylates MARCKS" xref: Reactome:R-HSA-400382 "CSNK1E,CSNK1D phosphorylate CRY and PER proteins" xref: Reactome:R-HSA-4088134 "PLK1 phosphorylates FOXM1" xref: Reactome:R-HSA-419083 "Myosin phosphatase inactivation by ROCK" xref: Reactome:R-HSA-419087 "LIM kinase phosphorylation by ROCK" xref: Reactome:R-HSA-419197 "Myosin regulatory light chain phosphorylation by ROCK" xref: Reactome:R-HSA-419644 "Transphosphorylation of pLIMK1" xref: Reactome:R-HSA-428961 "Phosphorylation of cPLA2 by MAPK p38 alpha" xref: Reactome:R-HSA-429016 "ALOX5 is phosphorylated by MAPKAP2" xref: Reactome:R-HSA-429714 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP" xref: Reactome:R-HSA-432110 "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding" xref: Reactome:R-HSA-4332358 "Dissociation of CaM and CAMK2 autophosphorylation" xref: Reactome:R-HSA-4332363 "Autophosphorylation and activation of CAMK2" xref: Reactome:R-HSA-4332388 "Activation of MAP3K7 in response to WNT" xref: Reactome:R-HSA-4411383 "NLK phosphorylates TCF/LEF" xref: Reactome:R-HSA-4411402 "Activation of NLK" xref: Reactome:R-HSA-442724 "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)" xref: Reactome:R-HSA-442739 "PDPK1 phosphorylates RSKs" xref: Reactome:R-HSA-442832 "PAK phosphorylates cortactin" xref: Reactome:R-HSA-445072 "Interaction of PAK1 with Rac1-GTP" xref: Reactome:R-HSA-446694 "IRAK4 phosphorylates IRAK1" xref: Reactome:R-HSA-446701 "IRAK4-activated IRAK1 autophosphorylates" xref: Reactome:R-HSA-448948 "Phosphorylation of E proteins by p38 MAPK" xref: Reactome:R-HSA-448955 "Phosphorylation of MEF2 proteins by p38" xref: Reactome:R-HSA-450222 "Active p38 MAPK phosphorylates MAPKAPK2 or 3" xref: Reactome:R-HSA-450325 "c-FOS activation by phospho ERK1/2" xref: Reactome:R-HSA-450463 "MK2 phosphorylates ZFP36 (Tristetraproline, TTP)" xref: Reactome:R-HSA-450474 "MK2 phosphorylates BRF1" xref: Reactome:R-HSA-450490 "Protein Kinase B/Akt phosphorylates BRF1" xref: Reactome:R-HSA-450499 "Protein Kinase B (AKT) phosphorylates KSRP" xref: Reactome:R-HSA-450827 "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2." xref: Reactome:R-HSA-451152 "MAP kinase p38 phosphorylates KSRP" xref: Reactome:R-HSA-451347 "Activation of JNK by DSCAM" xref: Reactome:R-HSA-4551570 "VANGL2 is phosphorylated in response to WNT5A" xref: Reactome:R-HSA-4608825 "DVL2 is phosphorylated after WNT5A binding to FZD" xref: Reactome:R-HSA-4793911 "MAPKAPK2 phosphorylates HSF1" xref: Reactome:R-HSA-5082387 "Phosphorylation of HSF1 at Ser230 induces transactivation" xref: Reactome:R-HSA-5082405 "Phosphorylation of HSF1 at Ser326 induces transactivation" xref: Reactome:R-HSA-5213464 "RIPK1 is phosphorylated" xref: Reactome:R-HSA-5213466 "RIPK3 is phosphorylated" xref: Reactome:R-HSA-5218814 "PAK2 autophorylates" xref: Reactome:R-HSA-5218821 "PDK1 phosphorylates PKC" xref: Reactome:R-HSA-5218826 "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732" xref: Reactome:R-HSA-5218854 "p-Y420-FYN is phosphorylated on S21" xref: Reactome:R-HSA-5218906 "RIPK3 phosphorylates MLKL" xref: Reactome:R-HSA-5218916 "p-MAPK2/3 phosphorylates HSP27" xref: Reactome:R-HSA-5228811 "NFKBIA variant is not phosphorylated within IkBA:NF-kappaB" xref: Reactome:R-HSA-5229343 "AXIN is phosphorylated in the destruction complex" xref: Reactome:R-HSA-5260201 "p-AKT2 phosphorylates C2CD5" xref: Reactome:R-HSA-5357472 "PAK1-3 autophosphorylates" xref: Reactome:R-HSA-5357477 "PAK1-3 phosphorylates VE-cadherin" xref: Reactome:R-HSA-5357831 "CYLD is phosphorylated by IKK" xref: Reactome:R-HSA-5578777 "DMPK phosphorylates PLN" xref: Reactome:R-HSA-5607722 "Active NIK phosphorylates IKKA dimer" xref: Reactome:R-HSA-5607726 "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB" xref: Reactome:R-HSA-5607732 "K63polyUb-TAK1 autophosphorylates" xref: Reactome:R-HSA-5607742 "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta" xref: Reactome:R-HSA-5610718 "CK1 phosphorylates p-GLI2" xref: Reactome:R-HSA-5610722 "CK1 phosphorylates p-GLI3" xref: Reactome:R-HSA-5610730 "GSK3 phosphorylates p-GLI2" xref: Reactome:R-HSA-5610732 "GSK3 phosphorylates p-GLI3" xref: Reactome:R-HSA-5624473 "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit" xref: Reactome:R-HSA-5624492 "PAK phosphorylates p21 RAF1 on S338" xref: Reactome:R-HSA-5627775 "Autophosphorylation of PAK1,2,3" xref: Reactome:R-HSA-5632670 "CSNK1A1 phosphorylates SMO dimer" xref: Reactome:R-HSA-5632672 "ADRBK1 phosphorylates SMO dimer" xref: Reactome:R-HSA-5635841 "GLI proteins are phosphorylated" xref: Reactome:R-HSA-5635842 "ULK3 phosphorylates GLI" xref: Reactome:R-HSA-5665868 "AMPK (complex) phosphorylates ULK1 (complex)" xref: Reactome:R-HSA-5666160 "AURKB phosphorylates DIAPH2-2 at kinetochores" xref: Reactome:R-HSA-5668545 "NIK autophosphorylates on T559" xref: Reactome:R-HSA-5668932 "PAK2 phosphorylates myosin regulatory light chain (MRLC)" xref: Reactome:R-HSA-5668947 "PAK1 phosphorylates myosin phosphatase" xref: Reactome:R-HSA-5668984 "PAK1 or PAK2 phosphorylates MYLK" xref: Reactome:R-HSA-5669250 "PAK1 phosphorylates FLNA" xref: Reactome:R-HSA-5671763 "p-T774-PKN1 phosphorylates PPP1R14A" xref: Reactome:R-HSA-5671919 "Activated CIT phosphorylates MRLCs" xref: Reactome:R-HSA-5672008 "Thr-180 of ULK1 is phosphorylated" xref: Reactome:R-HSA-5672010 "Active MTORC1 phosphorylates ULK1" xref: Reactome:R-HSA-5672828 "mTORC1 phosphorylates AKT1S1" xref: Reactome:R-HSA-5672948 "MARK3 phosphorylates KSR1" xref: Reactome:R-HSA-5672973 "MAP2Ks phosphorylate MAPKs" xref: Reactome:R-HSA-5672978 "RAF phosphorylates MAP2K dimer" xref: Reactome:R-HSA-5674496 "Activated MAPKs phosphorylate MAP2K1" xref: Reactome:R-HSA-5675194 "Activated MAPK phosphorylates RAF1" xref: Reactome:R-HSA-5675198 "Activated MAPKs phosphorylate BRAF" xref: Reactome:R-HSA-5675868 "ULK1 phosphorylates ATG13 and RB1CC1" xref: Reactome:R-HSA-5679205 "ULK1 phosphorylates Beclin-1" xref: Reactome:R-HSA-5682026 "MRN bound to shortened telomeres activates ATM" xref: Reactome:R-HSA-5682101 "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer" xref: Reactome:R-HSA-5682598 "ATM phosphorylates HERC2" xref: Reactome:R-HSA-5682983 "ATM phosphorylates WHSC1" xref: Reactome:R-HSA-5683425 "ATM phosphorylates TP53BP1 at DNA DSBs" xref: Reactome:R-HSA-5683792 "p-T68-CHEK2 autophosphorylates" xref: Reactome:R-HSA-5683801 "CHEK2 phosphorylates BRCA1" xref: Reactome:R-HSA-5683964 "ATM phosphorylates EYA1-4" xref: Reactome:R-HSA-5684096 "CDK2 phosphorylates RBBP8" xref: Reactome:R-HSA-5684140 "ATM phosphorylates RBBP8" xref: Reactome:R-HSA-5684887 "Activation of CHEK1 at resected DNA DSBs" xref: Reactome:R-HSA-5685156 "ATR phosphorylates RPA2" xref: Reactome:R-HSA-5685230 "CHEK1 phosphorylates RAD51" xref: Reactome:R-HSA-5685242 "CHEK1 phosphorylates BRCA2" xref: Reactome:R-HSA-5686578 "Activated ATM phosphorylates ABL1" xref: Reactome:R-HSA-5686704 "Activated ATM phosphorylates DCLRE1C" xref: Reactome:R-HSA-5687086 "PAK1,2,3 phosphorylates MAPK6,4" xref: Reactome:R-HSA-5687090 "p-S MAPK6 phosphorylates NCOA3" xref: Reactome:R-HSA-5687094 "p-S MAPK6,4 phosphorylate MAPKAPK5" xref: Reactome:R-HSA-5687101 "p-T182 MAPKAPK5 phosphorylates FOXO3" xref: Reactome:R-HSA-5687121 "p-S MAPKAPK5 phosphorylates HSPB1" xref: Reactome:R-HSA-5687183 "PRKDC phosphorylates DCLRE1C at DNA DSBs" xref: Reactome:R-HSA-5690250 "p-T182-MAPKAPK5 phoshphorylates DNAJB1" xref: Reactome:R-HSA-5692768 "MAPKAPK5 phosphorylates KALRN" xref: Reactome:R-HSA-5692775 "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs" xref: Reactome:R-HSA-5692779 "p-S182 MAPKAPK5 phosphorylates FOXO1" xref: Reactome:R-HSA-5693536 "ATM phosphorylates MDC1" xref: Reactome:R-HSA-5693540 "MRN activates ATM" xref: Reactome:R-HSA-5693549 "ATM phosphorylates histone H2AFX on S139 at DNA DSBs" xref: Reactome:R-HSA-5693551 "Phosphorylation of BRCA1-A complex at multiple sites by ATM" xref: Reactome:R-HSA-5693575 "DNA-PKcs autophosphorylates" xref: Reactome:R-HSA-5693598 "ATM phosphorylates NBN" xref: Reactome:R-HSA-5693609 "ATM phosphorylates TP53 at S15" xref: Reactome:R-HSA-5694441 "CSNK1D phosphorylates SEC23" xref: Reactome:R-HSA-6788392 "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA" xref: Reactome:R-HSA-6795290 "TORC2 complex phosphorylates SGK1" xref: Reactome:R-HSA-6795460 "SGK1 phosphorylates MDM2" xref: Reactome:R-HSA-6795473 "PDPK1 phosphorylates SGK1" xref: Reactome:R-HSA-6798372 "ATM phosphorylates DYRK2" xref: Reactome:R-HSA-6798374 "DYRK2 phosphorylates TP53" xref: Reactome:R-HSA-6799097 "ATM phosphorylates ZNF420" xref: Reactome:R-HSA-6799246 "CHEK1 phosphorylates TP53" xref: Reactome:R-HSA-6799332 "ATR phosphorylates TP53" xref: Reactome:R-HSA-6799409 "HIPK2 phosphorylates TP53" xref: Reactome:R-HSA-6800490 "ATM phosphorylates PIDD1" xref: Reactome:R-HSA-6801666 "PLK2 phosphorylates CENPJ" xref: Reactome:R-HSA-6801675 "PLK2 phosphorylates NPM1" xref: Reactome:R-HSA-6802911 "High kinase activity BRAF complexes phosphorylate MAP2Ks" xref: Reactome:R-HSA-6802919 "RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks" xref: Reactome:R-HSA-6802926 "Mutant RAS:p-RAF complexes phosphorylate MAP2Ks" xref: Reactome:R-HSA-6802933 "p-BRAF and RAF fusion dimers phosphorylate MAP2Ks" xref: Reactome:R-HSA-6802935 "MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers" xref: Reactome:R-HSA-6802943 "RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks" xref: Reactome:R-HSA-6802973 "PLK3 phosphorylates CDC25C" xref: Reactome:R-HSA-6804266 "CHEK2 phosphorylates TTC5" xref: Reactome:R-HSA-6804276 "ATM phosphorylates TTC5" xref: Reactome:R-HSA-6804955 "ATM phosphorylates MDM2" xref: Reactome:R-HSA-6805059 "CK2:FACT phosphorylates TP53" xref: Reactome:R-HSA-6805103 "AURKA phosphorylates TP53" xref: Reactome:R-HSA-6805126 "AURKB phosphorylates TP53" xref: Reactome:R-HSA-6805276 "CDK5 phosphorylates TP53" xref: Reactome:R-HSA-6805285 "PLK3 phosphorylates TP53" xref: Reactome:R-HSA-6805399 "TAF1 phosphorylates TP53" xref: Reactome:R-HSA-6805479 "TP53RK phosphorylates TP53" xref: Reactome:R-HSA-6805640 "AKT phosphorylates KAT6A" xref: Reactome:R-HSA-6805785 "AKT phosphorylates PHF20" xref: Reactome:R-HSA-6810233 "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter" xref: Reactome:R-HSA-6811454 "MAPKs phosphorylate PP2A" xref: Reactome:R-HSA-6814409 "CK2 phosphorylates PDCL" xref: Reactome:R-HSA-69604 "Phosphorylation of Cdc25A at Ser-123 by Chk1" xref: Reactome:R-HSA-69608 "Phosphorylation of Cdc25A at Ser-123 by Chk2" xref: Reactome:R-HSA-69685 "CHEK2 phosphorylates TP53" xref: Reactome:R-HSA-69891 "Phosphorylation and activation of CHEK2 by ATM" xref: Reactome:R-HSA-75010 "Phosphorylation of Cdc25C at Ser 216 by Chk1" xref: Reactome:R-HSA-75028 "Phosphorylation of Wee1 kinase by Chk1" xref: Reactome:R-HSA-75809 "Phosphorylation of Cdc25C at Ser216 by CHEK2" xref: Reactome:R-HSA-75820 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta" xref: Reactome:R-HSA-77071 "Phosphorylation (Ser5) of RNA pol II CTD" xref: Reactome:R-HSA-8850945 "Casein kinase II phosphorylates PTEN" xref: Reactome:R-HSA-8852306 "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends" xref: Reactome:R-HSA-8852317 "PLK1 phosphorylates GTSE1" xref: Reactome:R-HSA-8853419 "TPX2 promotes AURKA autophosphorylation" xref: Reactome:R-HSA-8853444 "AURKA phosphorylates PHLDA1" xref: Reactome:R-HSA-8854908 "PKA phosphorylates RET:GDNF:GFRA dimer" xref: Reactome:R-HSA-8856813 "AAK1 phosphorylates AP-2 mu subunit at T156" xref: Reactome:R-HSA-8863007 "p25-bound CDK5 phosphorylates CDC25B" xref: Reactome:R-HSA-8863011 "p25-bound CDK5 phosphorylates CDC25C" xref: Reactome:R-HSA-8863014 "p25-bound CDK5 phosphorylates CDC25A" xref: Reactome:R-HSA-8863895 "IKKB phosphorylates SNAP23" xref: Reactome:R-HSA-8868118 "MAPK12 phosphorylates PTPN3" xref: Reactome:R-HSA-8868260 "CDK5:p25 phosphorylates GOLGA2" xref: Reactome:R-HSA-8868340 "CDK5:p25 phosphorylates lamin B1" xref: Reactome:R-HSA-8868344 "CDK5:p25 phosphorylates lamin A" xref: Reactome:R-HSA-8868567 "CDK5:p25 phosphorylates PRDX1" xref: Reactome:R-HSA-8868573 "CDK5:p25 phosphorylates PRDX2" xref: Reactome:R-HSA-8868666 "CDK5:p25 phosphorylates JUN" xref: Reactome:R-HSA-8870558 "CDK5:p25 phosphorylates FOXO3" xref: Reactome:R-HSA-8873929 "Casein kinase II phosphorylates STARD10" xref: Reactome:R-HSA-8876446 "p-ULK1 phosphorylates DENND3" xref: Reactome:R-HSA-8877691 "MAP2K6 phosphorylates PIP4K2B" xref: Reactome:R-HSA-8878050 "HIPK2 phosphorylates RUNX1 and EP300" xref: Reactome:R-HSA-8878054 "HIPK2 phosphorylates RUNX1" xref: Reactome:R-HSA-8933446 "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling" xref: Reactome:R-HSA-8939963 "Activated AKT phosphorylates RUNX2" xref: Reactome:R-HSA-8940100 "CDK1 phosphorylates VCPIP1" xref: Reactome:R-HSA-8942836 "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6" xref: Reactome:R-HSA-8944454 "mTORC1 phosphorylates MAF1" xref: Reactome:R-HSA-8948039 "FUNDC1 is phosphorylated by CK2" xref: Reactome:R-HSA-8948146 "FUNDC1 is phosphorylated by ULK1 at Ser17" xref: Reactome:R-HSA-8948757 "AKT phosphorylates MKRN1" xref: Reactome:R-HSA-8952289 "FAM20C phosphorylates FAM20C substrates" xref: Reactome:R-HSA-9007539 "CHEK1 phosphorylates E2F6" xref: Reactome:R-HSA-9008480 "GSK3B phosphorylates RUNX2" xref: Reactome:R-HSA-9008822 "PPM1D dephosphorylates RUNX2" xref: Reactome:R-HSA-9009208 "Activated ERKs phosphorylate RUNX2" xref: Reactome:R-HSA-9012319 "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD" xref: Reactome:R-HSA-9013978 "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex" xref: Reactome:R-HSA-9022314 "HIPK2 phosphorylates MECP2" xref: Reactome:R-HSA-9023132 "AURKB phosphorylates MECP2 at S423" xref: Reactome:R-HSA-9032751 "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3" xref: Reactome:R-HSA-9032863 "CDK5 phosphorylates NTRK2" xref: Reactome:R-HSA-912470 "ATR phosphorylates Histone H2A.X at unsynapsed regions" xref: Reactome:R-HSA-913996 "PKA/PKG phosphorylate Rap1GAP2" xref: Reactome:R-HSA-918229 "Phosphorylation and release of IRF3/IRF7" xref: Reactome:R-HSA-933525 "Phosphorylation and release of IRF7" xref: Reactome:R-HSA-934559 "SPRY2 is phosphorylated by phosphorylated MNK1" xref: Reactome:R-HSA-936951 "Activation of TAK1 complex bound to activated TLR4 complex" xref: Reactome:R-HSA-937022 "IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP" xref: Reactome:R-HSA-937059 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex" xref: Reactome:R-HSA-9604328 "AKT1 phosphorylates NOTCH4" xref: Reactome:R-HSA-9610153 "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF" xref: Reactome:R-HSA-9610156 "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF" xref: Reactome:R-HSA-9610163 "BRAF autophosphorylates downstream of RAP1 and NGF" xref: Reactome:R-HSA-9612501 "SGK phosphorylates CREB1" xref: Reactome:R-HSA-9612509 "SGK phosphorylates SRF" xref: Reactome:R-HSA-9612980 "BRAF in Rap1-GTP complex:BRAF complex autophosphorylates" xref: Reactome:R-HSA-9613530 "PRKAA2 phosphorylates PLINs" xref: Reactome:R-HSA-9619515 "AMPK phosphorylates MAPT" xref: Reactome:R-HSA-9619843 "ERKs phosphorylate RSKs" xref: Reactome:R-HSA-9620004 "RSKs autophosphorylate" xref: Reactome:R-HSA-9624526 "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR" xref: Reactome:R-HSA-9626880 "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345" xref: Reactome:R-HSA-9627089 "CASP9 is phosphorylated at T125" xref: Reactome:R-HSA-9632868 "CDKN1B is phosphorylated in response to estrogen" xref: Reactome:R-HSA-9633008 "p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1" xref: Reactome:R-HSA-9633742 "EIF2AK4 (GCN2) dimer autophosphorylates" xref: Reactome:R-HSA-9634702 "LINC01139 promotes phosphorylation of HIF1A by LRRK2" xref: Reactome:R-HSA-9645535 "ALPK1 phosphorylates TIFA" xref: Reactome:R-HSA-9648089 "NEK6 and NEK7 phosphorylate EML4" xref: Reactome:R-HSA-9648883 "p-T-EIF2AK1:ferriheme dimer autophosphorylates" xref: Reactome:R-HSA-9648888 "p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha)" xref: Reactome:R-HSA-9652165 "MAP2K mutants constitutively phosphorylate MAPKs" xref: Reactome:R-HSA-9653503 "KRAS4B is phosphorylated on serine 181" xref: Reactome:R-HSA-9656214 "MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants" xref: Reactome:R-HSA-9656215 "RAF1 mutant complexes phosphorylate MAP2K dimer" xref: Reactome:R-HSA-9662823 "PLK2, MAPK14 phosphorylate ADAM17" xref: Reactome:R-HSA-9673346 "Unknown kinase phosphorylates p-DVL" xref: Reactome:R-HSA-9681627 "GSK3 phosphorylates N" xref: Reactome:R-HSA-9683664 "GSK3B phosphorylates Ncap" xref: Reactome:R-HSA-9694293 "GSK3B phosphorylates Ncap" xref: Reactome:R-HSA-9694620 "GSK3 phosphorylates N" xref: Reactome:R-HSA-9699579 "AKT phosphorylates FOXO3 downstream of FLT3" xref: Reactome:R-HSA-975125 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9" xref: Reactome:R-HSA-975134 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9" xref: Reactome:R-HSA-975160 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9" xref: Reactome:R-HSA-975170 "IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9" xref: Reactome:R-HSA-975180 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9" xref: Reactome:R-HSA-975853 "Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR" xref: Reactome:R-HSA-975861 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex" xref: Reactome:R-HSA-975865 "IRAK4 autophosphorylation within the complex activated TLR:MyD88" xref: Reactome:R-HSA-975874 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex" xref: Reactome:R-HSA-975878 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR" is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0004707 name: MAP kinase activity namespace: molecular_function alt_id: GO:0008338 alt_id: GO:0008339 alt_id: GO:0016908 alt_id: GO:0016909 def: "Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli." [GOC:ma, ISBN:0198547684] synonym: "ATP:protein phosphotransferase (MAPKK-activated) activity" RELATED [EC:2.7.11.24] synonym: "ERK" RELATED [EC:2.7.11.24] synonym: "ERK1" EXACT [] synonym: "ERK2" RELATED [] synonym: "extracellular signal-regulated kinase activity" NARROW [EC:2.7.11.24] synonym: "MAP kinase 1 activity" NARROW [] synonym: "MAP kinase 2 activity" NARROW [] synonym: "MAPK" RELATED [EC:2.7.11.24, PMID:20811974] synonym: "MBP kinase I activity" NARROW [EC:2.7.11.24] synonym: "MBP kinase II activity" NARROW [EC:2.7.11.24] synonym: "mitogen activated kinase activity" EXACT [] synonym: "mitogen-activated protein kinase activity" RELATED [EC:2.7.11.24] synonym: "myelin basic protein kinase activity" NARROW [EC:2.7.11.24] synonym: "SAP kinase activity" NARROW [] synonym: "SAPK" NARROW [] synonym: "stress-activated kinase activity" NARROW [] synonym: "stress-activated protein kinase activity" NARROW [] xref: EC:2.7.11.24 xref: KEGG_REACTION:R00162 xref: MetaCyc:2.7.11.24-RXN xref: Reactome:R-HSA-111898 "Phosphorylation of cPLA2 by ERK-2" xref: Reactome:R-HSA-198733 "ERK5 is activated" xref: Reactome:R-HSA-445079 "Phosphorylation of L1 by ERK" xref: Reactome:R-HSA-451366 "Activation of p38MAPK by DSCAM" xref: Reactome:R-HSA-5654560 "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2." xref: Reactome:R-HSA-5654562 "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2" xref: Reactome:R-HSA-5654565 "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2." xref: Reactome:R-HSA-5654566 "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2." xref: Reactome:R-HSA-73722 "Phosphorylation of UBF-1:rDNA Promoter" xref: Reactome:R-HSA-9626832 "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345" is_a: GO:0004674 ! protein serine/threonine kinase activity relationship: part_of GO:0000165 ! MAPK cascade [Term] id: GO:0004711 name: ribosomal protein S6 kinase activity namespace: molecular_function def: "Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP." [GOC:mah, PMID:9822608] is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004745 name: retinol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+." [EC:1.1.1.105] synonym: "all-trans retinol dehydrogenase activity" BROAD [EC:1.1.1.105] synonym: "MDR" RELATED [EC:1.1.1.105] synonym: "microsomal retinol dehydrogenase activity" BROAD [EC:1.1.1.105] synonym: "retinal reductase activity" BROAD [GOC:ecd, PMID:12036956] synonym: "retinene reductase activity" BROAD [EC:1.1.1.105] synonym: "retinol (vitamin A1) dehydrogenase activity" BROAD [EC:1.1.1.105] synonym: "retinol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.105] xref: EC:1.1.1.105 xref: MetaCyc:RETINOL-DEHYDROGENASE-RXN xref: Reactome:R-HSA-2454081 "RDH5 oxidises 11cROL to 11cRAL" xref: Reactome:R-HSA-2466832 "Defective RDH5 does not oxidise 11cROL to 11cRAL and causes RPA" xref: Reactome:R-HSA-5362518 "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL" xref: Reactome:R-HSA-5362564 "ADH1A,1C,4 oxidise atROL to atRAL in vitro" xref: Reactome:R-HSA-5362721 "RDH5,RDH11 oxidise 11cROL to 11cRAL" xref: RHEA:21284 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0005575 name: cellular_component namespace: cellular_component alt_id: GO:0008372 def: "A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome)." [GOC:pdt, NIF_Subcellular:sao1337158144] comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "cell or subcellular entity" EXACT [] synonym: "cellular component" EXACT [] synonym: "subcellular entity" RELATED [NIF_Subcellular:nlx_subcell_100315] xref: NIF_Subcellular:sao1337158144 [Term] id: GO:0005622 name: intracellular anatomical structure namespace: cellular_component def: "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant synonym: "internal to cell" EXACT [] synonym: "intracellular" EXACT [] synonym: "nucleocytoplasm" RELATED [GOC:mah] synonym: "protoplasm" EXACT [] synonym: "protoplast" RELATED [GOC:mah] xref: Wikipedia:Intracellular is_a: GO:0110165 ! cellular anatomical entity property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/17776 xsd:anyURI [Term] id: GO:0005694 name: chromosome namespace: cellular_component def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast synonym: "chromatid" RELATED [] synonym: "interphase chromosome" NARROW [] synonym: "prophase chromosome" NARROW [] xref: Wikipedia:Chromosome is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0005737 name: cytoplasm namespace: cellular_component def: "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: Wikipedia:Cytoplasm is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005622 ! intracellular anatomical structure [Term] id: GO:0005773 name: vacuole namespace: cellular_component def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "vacuolar carboxypeptidase Y" RELATED [] xref: Wikipedia:Vacuole is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005856 name: cytoskeleton namespace: cellular_component def: "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: Wikipedia:Cytoskeleton is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0005884 name: actin filament namespace: cellular_component def: "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339] synonym: "microfilament" EXACT [] xref: FMA:63850 xref: NIF_Subcellular:sao1588493326 xref: Wikipedia:Actin is_a: GO:0099513 ! polymeric cytoskeletal fiber relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0005886 name: plasma membrane namespace: cellular_component alt_id: GO:0005904 def: "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_plant subset: goslim_yeast synonym: "bacterial inner membrane" NARROW [] synonym: "cell membrane" EXACT [] synonym: "cellular membrane" EXACT [NIF_Subcellular:sao6433132645] synonym: "cytoplasmic membrane" EXACT [] synonym: "inner endospore membrane" NARROW [] synonym: "juxtamembrane" BROAD [] synonym: "plasma membrane lipid bilayer" NARROW [GOC:mah] synonym: "plasmalemma" EXACT [] xref: NIF_Subcellular:sao1663586795 xref: Wikipedia:Cell_membrane is_a: GO:0016020 ! membrane relationship: part_of GO:0071944 ! cell periphery [Term] id: GO:0005929 name: cilium namespace: cellular_component alt_id: GO:0072372 def: "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. Also, 'cilium' may be used when axonemal structure and/or motility are unknown, or when axonemal structure is unusual. For all other cases, please refer to children of 'cilium'. Finally, note that any role of ciliary proteins in sensory events should be captured by annotating to relevant biological process terms. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir synonym: "eukaryotic flagellum" EXACT [] synonym: "flagellum" RELATED [] synonym: "microtubule-based flagellum" EXACT [] synonym: "primary cilium" NARROW [] xref: FMA:67181 xref: NIF_Subcellular:sao787716553 xref: Wikipedia:Cilium is_a: GO:0043226 ! organelle is_a: GO:0120025 ! plasma membrane bounded cell projection relationship: has_part GO:0030990 ! intraciliary transport particle property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3312 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0005938 name: cell cortex namespace: cellular_component def: "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] subset: goslim_aspergillus subset: goslim_candida subset: goslim_yeast synonym: "cell periphery" RELATED [] synonym: "peripheral cytoplasm" RELATED [] xref: Wikipedia:Cell_cortex is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: part_of GO:0071944 ! cell periphery relationship: part_of GO:0071944 ! cell periphery [Term] id: GO:0006139 name: nucleobase-containing compound metabolic process namespace: biological_process alt_id: GO:0055134 def: "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] subset: goslim_pir subset: goslim_plant synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] synonym: "nucleobase, nucleoside and nucleotide metabolic process" RELATED [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0044238 ! primary metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0006325 name: chromatin organization namespace: biological_process alt_id: GO:0016568 def: "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GOC:mah, GOC:vw, PMID:20404130] subset: goslim_pombe subset: goslim_yeast synonym: "chromatin modification" RELATED [] synonym: "chromatin organisation" EXACT [GOC:mah] synonym: "establishment or maintenance of chromatin architecture" EXACT [GOC:mah] is_a: GO:0016043 ! cellular component organization relationship: part_of GO:0051276 ! chromosome organization [Term] id: GO:0006351 name: transcription, DNA-templated namespace: biological_process alt_id: GO:0006350 alt_id: GO:0061018 alt_id: GO:0061022 def: "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] subset: goslim_aspergillus subset: goslim_drosophila subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe synonym: "cellular transcription" BROAD [] synonym: "cellular transcription, DNA-dependent" EXACT [] synonym: "DNA-dependent transcription" EXACT [] synonym: "transcription" BROAD [] synonym: "transcription regulator activity" RELATED [] synonym: "transcription, DNA-dependent" EXACT [GOC:txnOH] xref: Wikipedia:Transcription_(genetics) is_a: GO:0034645 ! cellular macromolecule biosynthetic process is_a: GO:0097659 ! nucleic acid-templated transcription relationship: part_of GO:0010467 ! gene expression [Term] id: GO:0006355 name: regulation of transcription, DNA-templated namespace: biological_process alt_id: GO:0032583 alt_id: GO:0045449 alt_id: GO:0061019 def: "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] synonym: "regulation of cellular transcription, DNA-dependent" EXACT [] synonym: "regulation of gene-specific transcription" RELATED [] synonym: "regulation of transcription, DNA-dependent" EXACT [GOC:txnOH] synonym: "transcriptional control" BROAD [] is_a: GO:0010468 ! regulation of gene expression is_a: GO:1903506 ! regulation of nucleic acid-templated transcription is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006351 ! transcription, DNA-templated relationship: regulates GO:0006351 ! transcription, DNA-templated [Term] id: GO:0006357 name: regulation of transcription by RNA polymerase II namespace: biological_process alt_id: GO:0006358 alt_id: GO:0010551 def: "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] synonym: "global transcription regulation from Pol II promoter" RELATED [] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [] synonym: "regulation of global transcription from Pol II promoter" RELATED [] synonym: "regulation of transcription from Pol II promoter" EXACT [] synonym: "regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "regulation of transcription from RNA polymerase II promoter, global" RELATED [] is_a: GO:0006355 ! regulation of transcription, DNA-templated intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006366 ! transcription by RNA polymerase II relationship: regulates GO:0006366 ! transcription by RNA polymerase II [Term] id: GO:0006366 name: transcription by RNA polymerase II namespace: biological_process alt_id: GO:0032568 alt_id: GO:0032569 def: "The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] subset: goslim_yeast synonym: "gene-specific transcription from RNA polymerase II promoter" RELATED [] synonym: "general transcription from RNA polymerase II promoter" RELATED [] synonym: "RNA polymerase II transcription factor activity" RELATED [] synonym: "specific transcription from RNA polymerase II promoter" RELATED [GOC:mah] synonym: "transcription from Pol II promoter" EXACT [] synonym: "transcription from RNA polymerase II promoter" EXACT [] is_a: GO:0006351 ! transcription, DNA-templated property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/14854 xsd:anyURI [Term] id: GO:0006457 name: protein folding namespace: biological_process alt_id: GO:0007022 alt_id: GO:0007024 alt_id: GO:0007025 def: "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "alpha-tubulin folding" NARROW [GOC:mah] synonym: "beta-tubulin folding" NARROW [GOC:mah] synonym: "chaperone activity" RELATED [] synonym: "chaperonin ATPase activity" RELATED [] synonym: "chaperonin-mediated tubulin folding" NARROW [GOC:mah] synonym: "co-chaperone activity" RELATED [] synonym: "co-chaperonin activity" RELATED [] synonym: "glycoprotein-specific chaperone activity" RELATED [] synonym: "non-chaperonin molecular chaperone ATPase activity" RELATED [] synonym: "protein complex assembly, multichaperone pathway" RELATED [] xref: Wikipedia:Protein_folding is_a: GO:0009987 ! cellular process [Term] id: GO:0006464 name: cellular protein modification process namespace: biological_process def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant synonym: "process resulting in protein modification" RELATED [] synonym: "protein modification process" BROAD [GOC:bf, GOC:jl] synonym: "protein tagging activity" RELATED [] is_a: GO:0036211 ! protein modification process is_a: GO:0044267 ! cellular protein metabolic process [Term] id: GO:0006468 name: protein phosphorylation namespace: biological_process def: "The process of introducing a phosphate group on to a protein." [GOC:hb] subset: goslim_yeast synonym: "protein amino acid phosphorylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process is_a: GO:0016310 ! phosphorylation [Term] id: GO:0006469 name: negative regulation of protein kinase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity." [GOC:go_curators] synonym: "down regulation of protein kinase activity" EXACT [] synonym: "down-regulation of protein kinase activity" EXACT [] synonym: "downregulation of protein kinase activity" EXACT [] synonym: "inhibition of protein kinase activity" NARROW [] is_a: GO:0001933 ! negative regulation of protein phosphorylation is_a: GO:0033673 ! negative regulation of kinase activity is_a: GO:0045859 ! regulation of protein kinase activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0004672 ! protein kinase activity relationship: negatively_regulates GO:0004672 ! protein kinase activity [Term] id: GO:0006473 name: protein acetylation namespace: biological_process def: "The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai] synonym: "protein amino acid acetylation" EXACT [GOC:bf] is_a: GO:0043543 ! protein acylation [Term] id: GO:0006475 name: internal protein amino acid acetylation namespace: biological_process def: "The addition of an acetyl group to a non-terminal amino acid in a protein." [GOC:mah] is_a: GO:0006473 ! protein acetylation [Term] id: GO:0006479 name: protein methylation namespace: biological_process def: "The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:ai] synonym: "protein amino acid methylation" EXACT [GOC:bf] is_a: GO:0008213 ! protein alkylation is_a: GO:0043414 ! macromolecule methylation [Term] id: GO:0006508 name: proteolysis namespace: biological_process def: "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] comment: This term was intentionally placed under 'protein metabolic process ; GO:0019538' rather than 'protein catabolic process ; GO:0030163' to cover all processes centered on breaking peptide bonds, including those involved in protein processing. subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir synonym: "ATP-dependent proteolysis" NARROW [GOC:mah] synonym: "peptidolysis" EXACT [] xref: Wikipedia:Proteolysis is_a: GO:0019538 ! protein metabolic process [Term] id: GO:0006575 name: cellular modified amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai] synonym: "amino acid derivative metabolic process" EXACT [] synonym: "cellular amino acid derivative metabolic process" EXACT [] synonym: "cellular amino acid derivative metabolism" EXACT [] synonym: "cellular modified amino acid metabolism" EXACT [GOC:mah] synonym: "modified amino acid metabolic process" EXACT [GOC:mah] synonym: "modified amino acid metabolism" EXACT [GOC:mah] is_a: GO:0044237 ! cellular metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0006590 name: thyroid hormone generation namespace: biological_process def: "The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones." [GOC:jl, ISBN:0716720094] comment: Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because thyroid hormones can only be formed by the proteolysis of a larger molecule (see term definition). The word 'generation' is therefore used in place of biosynthesis. is_a: GO:0042403 ! thyroid hormone metabolic process [Term] id: GO:0006725 name: cellular aromatic compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells." [GOC:ai, ISBN:0198506732] subset: goslim_pir synonym: "aromatic compound metabolism" EXACT [] synonym: "aromatic hydrocarbon metabolic process" NARROW [] synonym: "aromatic hydrocarbon metabolism" NARROW [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0006793 name: phosphorus metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4)." [GOC:ai] subset: goslim_pir synonym: "phosphorus metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0006796 name: phosphate-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai] synonym: "phosphate metabolic process" RELATED [] synonym: "phosphate metabolism" EXACT [] is_a: GO:0006793 ! phosphorus metabolic process [Term] id: GO:0006807 name: nitrogen compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732] subset: goslim_metagenomics subset: goslim_pir synonym: "nitrogen compound metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0006810 name: transport namespace: biological_process alt_id: GO:0015457 alt_id: GO:0015460 alt_id: GO:0044765 def: "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter, pore or motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah] comment: Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport. subset: gocheck_do_not_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "single-organism transport" RELATED [] synonym: "small molecule transport" NARROW [] synonym: "solute:solute exchange" NARROW [] is_a: GO:0051234 ! establishment of localization created_by: jl creation_date: 2012-12-13T16:25:32Z [Term] id: GO:0006811 name: ion transport namespace: biological_process def: "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_drosophila subset: goslim_pir subset: goslim_yeast is_a: GO:0006810 ! transport [Term] id: GO:0006812 name: cation transport namespace: biological_process alt_id: GO:0006819 alt_id: GO:0015674 alt_id: GO:0072512 def: "The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "di-, tri-valent inorganic cation transport" NARROW [GOC:mah] synonym: "trivalent inorganic cation transport" NARROW [] is_a: GO:0006811 ! ion transport [Term] id: GO:0006816 name: calcium ion transport namespace: biological_process def: "The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "calcium transport" EXACT [] synonym: "mitochondrial sodium/calcium ion exchange" NARROW [] synonym: "sodium:calcium exchange" NARROW [] is_a: GO:0030001 ! metal ion transport [Term] id: GO:0006820 name: anion transport namespace: biological_process alt_id: GO:0006822 def: "The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006811 ! ion transport [Term] id: GO:0006886 name: intracellular protein transport namespace: biological_process alt_id: GO:0032779 def: "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] synonym: "copper-induced intracellular protein transport" RELATED [GOC:al] is_a: GO:0015031 ! protein transport is_a: GO:0046907 ! intracellular transport relationship: part_of GO:0034613 ! cellular protein localization [Term] id: GO:0006903 name: vesicle targeting namespace: biological_process def: "The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo." [GOC:mah, PMID:17335816] is_a: GO:0009987 ! cellular process relationship: part_of GO:0016192 ! vesicle-mediated transport relationship: part_of GO:0051650 ! establishment of vesicle localization [Term] id: GO:0006915 name: apoptotic process namespace: biological_process alt_id: GO:0006917 alt_id: GO:0008632 def: "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] synonym: "activation of apoptosis" NARROW [] synonym: "apoptosis" NARROW [] synonym: "apoptosis activator activity" RELATED [] synonym: "apoptosis signaling" NARROW [] synonym: "apoptotic cell death" EXACT [GOC:sl] synonym: "apoptotic program" NARROW [GOC:add] synonym: "apoptotic programmed cell death" EXACT [] synonym: "caspase-dependent programmed cell death" RELATED [] synonym: "cell suicide" BROAD [] synonym: "cellular suicide" BROAD [] synonym: "commitment to apoptosis" RELATED [] synonym: "induction of apoptosis" RELATED [] synonym: "induction of apoptosis by p53" RELATED [] synonym: "programmed cell death by apoptosis" EXACT [] synonym: "signaling (initiator) caspase activity" RELATED [] synonym: "type I programmed cell death" NARROW [] xref: Wikipedia:Apoptosis is_a: GO:0012501 ! programmed cell death property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0006928 name: movement of cell or subcellular component namespace: biological_process def: "The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore." [GOC:dgh, GOC:dph, GOC:jl, GOC:mlg] comment: Note that in GO cellular components include whole cells (cell is_a cellular component). subset: gocheck_do_not_annotate subset: goslim_pir synonym: "cell movement" RELATED [] synonym: "cellular component motion" EXACT [GOC:dph, GOC:jl] synonym: "cellular component movement" EXACT [] is_a: GO:0009987 ! cellular process [Term] id: GO:0006935 name: chemotaxis namespace: biological_process def: "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [ISBN:0198506732] synonym: "taxis in response to chemical stimulus" EXACT [] xref: Wikipedia:Chemotaxis is_a: GO:0042330 ! taxis relationship: part_of GO:0042221 ! response to chemical [Term] id: GO:0006950 name: response to stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant synonym: "response to abiotic stress" RELATED [] synonym: "response to biotic stress" RELATED [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0006996 name: organelle organization namespace: biological_process alt_id: GO:1902589 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_pir synonym: "organelle organisation" EXACT [] synonym: "organelle organization and biogenesis" RELATED [GOC:dph, GOC:jl, GOC:mah] synonym: "single organism organelle organization" EXACT [GOC:TermGenie] synonym: "single-organism organelle organization" RELATED [] is_a: GO:0016043 ! cellular component organization created_by: jl creation_date: 2013-12-19T15:25:51Z [Term] id: GO:0007010 name: cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "cytoskeletal organization and biogenesis" RELATED [GOC:mah] synonym: "cytoskeletal regulator activity" RELATED [] synonym: "cytoskeleton organisation" EXACT [] synonym: "cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0007017 name: microtubule-based process namespace: biological_process def: "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] subset: goslim_chembl is_a: GO:0009987 ! cellular process [Term] id: GO:0007018 name: microtubule-based movement namespace: biological_process def: "A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194] is_a: GO:0006928 ! movement of cell or subcellular component is_a: GO:0007017 ! microtubule-based process [Term] id: GO:0007049 name: cell cycle namespace: biological_process def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] subset: gocheck_do_not_manually_annotate subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_pir subset: goslim_plant synonym: "cell-division cycle" EXACT [] xref: Wikipedia:Cell_cycle is_a: GO:0009987 ! cellular process [Term] id: GO:0007051 name: spindle organization namespace: biological_process alt_id: GO:0043146 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:go_curators, GOC:mah] synonym: "spindle organisation" EXACT [] synonym: "spindle organization and biogenesis" RELATED [GOC:mah] synonym: "spindle stabilization" RELATED [] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:0022402 ! cell cycle process [Term] id: GO:0007052 name: mitotic spindle organization namespace: biological_process alt_id: GO:0000071 alt_id: GO:0030472 alt_id: GO:0043148 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:go_curators, GOC:mah] comment: In fission yeast most mitotic spindle organization occurs in the nucleus. synonym: "mitotic spindle organisation" EXACT [] synonym: "mitotic spindle organisation in nucleus" NARROW [] synonym: "mitotic spindle organization and biogenesis" RELATED [GOC:mah] synonym: "mitotic spindle organization and biogenesis in cell nucleus" NARROW [] synonym: "mitotic spindle organization and biogenesis in nucleus" NARROW [] synonym: "mitotic spindle organization in nucleus" NARROW [] synonym: "mitotic spindle stabilization" RELATED [] synonym: "spindle organization and biogenesis during mitosis" EXACT [] synonym: "spindle organization and biogenesis in nucleus during mitosis" NARROW [] is_a: GO:0007051 ! spindle organization is_a: GO:1902850 ! microtubule cytoskeleton organization involved in mitosis intersection_of: GO:0007051 ! spindle organization intersection_of: part_of GO:0000278 ! mitotic cell cycle property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/15341 xsd:anyURI [Term] id: GO:0007053 name: spindle assembly involved in male meiosis namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0090306 ! spindle assembly involved in meiosis intersection_of: GO:0051225 ! spindle assembly intersection_of: part_of GO:0007140 ! male meiotic nuclear division relationship: part_of GO:0007140 ! male meiotic nuclear division [Term] id: GO:0007088 name: regulation of mitotic nuclear division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators] synonym: "regulation of mitosis" EXACT [] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0140014 ! mitotic nuclear division relationship: regulates GO:0140014 ! mitotic nuclear division [Term] id: GO:0007112 name: male meiosis cytokinesis namespace: biological_process def: "A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai] synonym: "cytokinesis after male meiosis" EXACT [GOC:dph, GOC:tb] synonym: "cytokinesis involved in male meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0033206 ! meiotic cytokinesis intersection_of: GO:0000910 ! cytokinesis intersection_of: part_of GO:0007140 ! male meiotic nuclear division relationship: part_of GO:0007140 ! male meiotic nuclear division [Term] id: GO:0007140 name: male meiotic nuclear division namespace: biological_process def: "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah, GOC:vw] synonym: "male meiosis" RELATED [] synonym: "male nuclear division" BROAD [] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0140013 ! meiotic nuclear division intersection_of: GO:0000280 ! nuclear division intersection_of: part_of GO:0048232 ! male gamete generation intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0048232 ! male gamete generation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0007154 name: cell communication namespace: biological_process def: "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah] subset: goslim_pir subset: goslim_plant xref: Wikipedia:Cell_signaling is_a: GO:0009987 ! cellular process [Term] id: GO:0007155 name: cell adhesion namespace: biological_process alt_id: GO:0098602 def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe synonym: "cell adhesion molecule activity" RELATED [] synonym: "single organism cell adhesion" RELATED [] xref: Wikipedia:Cell_adhesion is_a: GO:0009987 ! cellular process is_a: GO:0022610 ! biological adhesion created_by: dos creation_date: 2014-04-15T15:59:10Z [Term] id: GO:0007162 name: negative regulation of cell adhesion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion." [GOC:go_curators] synonym: "cell adhesion receptor inhibitor activity" RELATED [] synonym: "down regulation of cell adhesion" EXACT [] synonym: "down-regulation of cell adhesion" EXACT [] synonym: "downregulation of cell adhesion" EXACT [] synonym: "inhibition of cell adhesion" NARROW [] is_a: GO:0030155 ! regulation of cell adhesion is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007155 ! cell adhesion relationship: negatively_regulates GO:0007155 ! cell adhesion [Term] id: GO:0007163 name: establishment or maintenance of cell polarity namespace: biological_process alt_id: GO:0030012 alt_id: GO:0030467 def: "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] subset: goslim_pombe synonym: "cell polarity" RELATED [GOC:mah, GOC:vw] synonym: "establishment and/or maintenance of cell polarity" RELATED [] synonym: "establishment and/or maintenance of cell polarization" RELATED [] is_a: GO:0009987 ! cellular process [Term] id: GO:0007164 name: establishment of tissue polarity namespace: biological_process def: "Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:jid] is_a: GO:0009653 ! anatomical structure morphogenesis property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0007165 name: signal transduction namespace: biological_process alt_id: GO:0023014 alt_id: GO:0023015 alt_id: GO:0023016 alt_id: GO:0023033 alt_id: GO:0023045 def: "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] comment: Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant synonym: "signal transduction by cis-phosphorylation" NARROW [] synonym: "signal transduction by conformational transition" NARROW [] synonym: "signal transduction by protein phosphorylation" NARROW [] synonym: "signal transduction by trans-phosphorylation" NARROW [] synonym: "signaling cascade" NARROW [] synonym: "signaling pathway" RELATED [] synonym: "signalling cascade" NARROW [] synonym: "signalling pathway" RELATED [GOC:mah] xref: Wikipedia:Signal_transduction is_a: GO:0009987 ! cellular process is_a: GO:0050794 ! regulation of cellular process relationship: part_of GO:0007154 ! cell communication relationship: part_of GO:0023052 ! signaling relationship: part_of GO:0051716 ! cellular response to stimulus [Term] id: GO:0007166 name: cell surface receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling] subset: goslim_drosophila synonym: "cell surface receptor linked signal transduction" EXACT [] synonym: "cell surface receptor linked signaling pathway" EXACT [GOC:bf] synonym: "cell surface receptor linked signalling pathway" EXACT [GOC:mah] is_a: GO:0007165 ! signal transduction [Term] id: GO:0007167 name: enzyme linked receptor protein signaling pathway namespace: biological_process def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, ISBN:0815316194] synonym: "enzyme linked receptor protein signalling pathway" EXACT [] is_a: GO:0007166 ! cell surface receptor signaling pathway [Term] id: GO:0007169 name: transmembrane receptor protein tyrosine kinase signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling] synonym: "transmembrane receptor protein tyrosine kinase signalling pathway" EXACT [] is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway [Term] id: GO:0007178 name: transmembrane receptor protein serine/threonine kinase signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] synonym: "transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT [] is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway [Term] id: GO:0007254 name: JNK cascade namespace: biological_process def: "An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:signaling, PMID:11790549, PMID:20811974] synonym: "c-Jun N-terminal kinase cascade" EXACT [PMID:20811974] synonym: "JNK1 cascade" NARROW [GOC:add] synonym: "JNK2 cascade" NARROW [GOC:add] synonym: "JNK3 cascade" NARROW [GOC:add] synonym: "MAPK10 cascade" NARROW [GOC:add] synonym: "MAPK8 cascade" NARROW [GOC:add] synonym: "MAPK9 cascade" NARROW [GOC:add] synonym: "SAPK cascade" BROAD [] synonym: "stress-activated protein kinase cascade" BROAD [] is_a: GO:0051403 ! stress-activated MAPK cascade [Term] id: GO:0007267 name: cell-cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions." [GOC:dos, GOC:mah] subset: goslim_chembl subset: goslim_generic subset: goslim_plant synonym: "cell-cell signalling" EXACT [] is_a: GO:0007154 ! cell communication is_a: GO:0023052 ! signaling [Term] id: GO:0007275 name: multicellular organism development namespace: biological_process def: "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] comment: Note that this term was 'developmental process'. subset: goslim_chembl subset: goslim_plant is_a: GO:0032501 ! multicellular organismal process is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0007276 name: gamete generation namespace: biological_process alt_id: GO:0009552 def: "The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell." [GOC:ems, GOC:mtg_sensu] synonym: "gametogenesis" RELATED [] is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0019953 ! sexual reproduction property_value: RO:0002161 NCBITaxon_Union:0000023 [Term] id: GO:0007283 name: spermatogenesis namespace: biological_process def: "The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821] synonym: "generation of spermatozoa" EXACT systematic_synonym [] xref: Wikipedia:Spermatogenesis is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048232 ! male gamete generation [Term] id: GO:0007284 name: spermatogonial cell division namespace: biological_process def: "The mitotic divisions of the primary spermatogonial cell (a primordial male germ cell) to form secondary spermatogonia (primary spermatocytes)." [GOC:bf, GOC:pr, ISBN:0879694238] comment: See also the Cell Ontology terms 'spermatogonium ; CL:0000020' and 'primary spermatocyte ; CL:0000656'. synonym: "spermatogonium division" EXACT [] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0051301 ! cell division relationship: part_of GO:0007283 ! spermatogenesis [Term] id: GO:0007338 name: single fertilization namespace: biological_process def: "The union of male and female gametes to form a zygote." [GOC:ems, GOC:mtg_sensu] synonym: "zygote biosynthesis" RELATED [] synonym: "zygote formation" RELATED [] is_a: GO:0009566 ! fertilization property_value: RO:0002161 NCBITaxon:58024 [Term] id: GO:0007343 name: egg activation namespace: biological_process def: "The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm." [GOC:bf, PMID:9630751] xref: Wikipedia:Egg_activation is_a: GO:0001775 ! cell activation is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0007346 name: regulation of mitotic cell cycle namespace: biological_process def: "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "mitotic cell cycle modulation" EXACT [] synonym: "mitotic cell cycle regulation" EXACT [] synonym: "mitotic cell cycle regulator" RELATED [] synonym: "modulation of mitotic cell cycle progression" EXACT [] synonym: "regulation of mitotic cell cycle progression" EXACT [] synonym: "regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0000278 ! mitotic cell cycle relationship: regulates GO:0000278 ! mitotic cell cycle [Term] id: GO:0007368 name: determination of left/right symmetry namespace: biological_process def: "The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:dph, GOC:jid] synonym: "determination of left/right asymmetry" EXACT [GOC:dph] is_a: GO:0009855 ! determination of bilateral symmetry [Term] id: GO:0007369 name: gastrulation namespace: biological_process def: "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846] subset: goslim_drosophila xref: Wikipedia:Gastrulation is_a: GO:0048598 ! embryonic morphogenesis relationship: has_part GO:0001705 ! ectoderm formation relationship: has_part GO:0001706 ! endoderm formation relationship: has_part GO:0001707 ! mesoderm formation [Term] id: GO:0007389 name: pattern specification process namespace: biological_process def: "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125] subset: goslim_drosophila synonym: "pattern biosynthesis" RELATED [] synonym: "pattern formation" RELATED [] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0007398 name: ectoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb] is_a: GO:0009888 ! tissue development [Term] id: GO:0007399 name: nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] subset: goslim_drosophila synonym: "pan-neural process" RELATED [] is_a: GO:0048731 ! system development [Term] id: GO:0007409 name: axonogenesis namespace: biological_process alt_id: GO:0007410 def: "De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] comment: Note that 'axonogenesis' differs from 'axon development' in that the latter also covers other processes, such as axon regeneration (regrowth after loss or damage, not necessarily of the whole axon). synonym: "axon growth" NARROW [] synonym: "axon morphogenesis" EXACT [GOC:bf, PMID:23517308] synonym: "neuron long process generation" EXACT systematic_synonym [] is_a: GO:0048812 ! neuron projection morphogenesis relationship: part_of GO:0048667 ! cell morphogenesis involved in neuron differentiation relationship: part_of GO:0061564 ! axon development [Term] id: GO:0007411 name: axon guidance namespace: biological_process alt_id: GO:0008040 def: "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] synonym: "axon chemotaxis" RELATED [] synonym: "axon growth cone guidance" NARROW [] synonym: "axon pathfinding" EXACT [GOC:mah] xref: Wikipedia:Axon_guidance is_a: GO:0097485 ! neuron projection guidance relationship: part_of GO:0007409 ! axonogenesis [Term] id: GO:0007492 name: endoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues." [GOC:dph, GOC:tb] is_a: GO:0009888 ! tissue development [Term] id: GO:0007498 name: mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] is_a: GO:0009888 ! tissue development [Term] id: GO:0007507 name: heart development namespace: biological_process alt_id: GO:0007511 def: "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] synonym: "cardiac development" RELATED [] synonym: "dorsal vessel development" NARROW [] xref: Wikipedia:Heart_development is_a: GO:0048513 ! animal organ development relationship: part_of GO:0072359 ! circulatory system development [Term] id: GO:0007548 name: sex differentiation namespace: biological_process def: "The establishment of the sex of an organism by physical differentiation." [GOC:ai] xref: Wikipedia:Sexual_differentiation is_a: GO:0003006 ! developmental process involved in reproduction [Term] id: GO:0007552 name: metamorphosis namespace: biological_process alt_id: GO:0046698 alt_id: GO:0046699 def: "A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544] xref: Wikipedia:Metamorphosis is_a: GO:0007275 ! multicellular organism development [Term] id: GO:0007610 name: behavior namespace: biological_process alt_id: GO:0023032 alt_id: GO:0044708 alt_id: GO:0044709 def: "The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity." [GOC:ems, GOC:jl, ISBN:0395448956, PMID:20160973] comment: 1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews.\n2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis). subset: gocheck_do_not_manually_annotate subset: goslim_agr subset: goslim_flybase_ribbon synonym: "behavioral response to stimulus" EXACT [] synonym: "behaviour" EXACT [] synonym: "behavioural response to stimulus" EXACT [] synonym: "single-organism behavior" RELATED [] xref: Wikipedia:Behavior is_a: GO:0050896 ! response to stimulus disjoint_from: GO:0032502 ! developmental process created_by: jl creation_date: 2012-09-20T14:06:08Z [Term] id: GO:0007617 name: mating behavior namespace: biological_process def: "The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." [GOC:ai, GOC:dph] synonym: "mating behaviour" EXACT [] xref: Wikipedia:Mating_behaviour is_a: GO:0019098 ! reproductive behavior intersection_of: GO:0007610 ! behavior intersection_of: part_of GO:0007618 ! mating relationship: part_of GO:0007618 ! mating [Term] id: GO:0007618 name: mating namespace: biological_process def: "The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes." [GOC:jl, ISBN:0387520546] is_a: GO:0044703 ! multi-organism reproductive process relationship: part_of GO:0019953 ! sexual reproduction [Term] id: GO:0007619 name: courtship behavior namespace: biological_process def: "The behavior of an organism for the purpose of attracting sexual partners." [GOC:ai, GOC:dph] synonym: "courtship behaviour" EXACT [] is_a: GO:0007617 ! mating behavior [Term] id: GO:0007626 name: locomotory behavior namespace: biological_process def: "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph] subset: goslim_drosophila synonym: "behavior via locomotion" EXACT [] synonym: "locomotion in response to stimulus" EXACT [] synonym: "locomotory behavioral response to stimulus" EXACT [] synonym: "locomotory behaviour" EXACT [] synonym: "locomotory behavioural response to stimulus" EXACT [] is_a: GO:0007610 ! behavior [Term] id: GO:0007631 name: feeding behavior namespace: biological_process alt_id: GO:0044366 alt_id: GO:0044367 alt_id: GO:0044368 alt_id: GO:0044369 alt_id: GO:0044370 alt_id: GO:0044371 alt_id: GO:0044372 def: "Behavior associated with the intake of food." [GOC:mah] comment: See also the biological process term 'behavior ; GO:0007610'. synonym: "behavioral response to food" EXACT [] synonym: "behavioural response to food" EXACT [] synonym: "eating" NARROW [] synonym: "feeding behaviour" EXACT [] synonym: "feeding from phloem of other organism" NARROW [] synonym: "feeding from plant phloem" NARROW [] synonym: "feeding from tissue of other organism" NARROW [] synonym: "feeding from vascular tissue of another organism" NARROW [] synonym: "feeding from xylem of other organism" NARROW [] synonym: "feeding on blood of other organism" NARROW [] synonym: "feeding on or from other organism" NARROW [] synonym: "feeding on plant sap" NARROW [] synonym: "hematophagy" NARROW [] synonym: "injection of substance into other organism during feeding on blood of other organism" NARROW [] synonym: "taking of blood meal" NARROW [] xref: Wikipedia:List_of_feeding_behaviours is_a: GO:0007610 ! behavior property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/18547 xsd:anyURI created_by: jl creation_date: 2011-10-27T03:53:33Z [Term] id: GO:0007632 name: visual behavior namespace: biological_process def: "The behavior of an organism in response to a visual stimulus." [GOC:jid, GOC:pr] synonym: "behavioral response to visual stimulus" EXACT [] synonym: "behavioural response to visual stimulus" EXACT [] synonym: "visual behaviour" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0009416 ! response to light stimulus is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0007634 name: optokinetic behavior namespace: biological_process def: "The behavior of an organism pertaining to movement of the eyes and of objects in the visual field, as in nystagmus." [GOC:jid, GOC:pr] synonym: "optokinetic behaviour" EXACT [] is_a: GO:0007632 ! visual behavior [Term] id: GO:0007635 name: chemosensory behavior namespace: biological_process def: "Behavior that is dependent upon the sensation of chemicals." [GOC:go_curators] synonym: "behavioral response to chemical stimulus" EXACT [] synonym: "behavioural response to chemical stimulus" EXACT [] synonym: "chemosensory behaviour" EXACT [] is_a: GO:0007610 ! behavior relationship: part_of GO:0042221 ! response to chemical [Term] id: GO:0007638 name: mechanosensory behavior namespace: biological_process def: "Behavior that is dependent upon the sensation of a mechanical stimulus." [GOC:go_curators] synonym: "behavioral response to mechanical stimulus" EXACT [] synonym: "behavioural response to mechanical stimulus" EXACT [] synonym: "mechanosensory behaviour" EXACT [] is_a: GO:0007610 ! behavior relationship: part_of GO:0009612 ! response to mechanical stimulus [Term] id: GO:0008015 name: blood circulation namespace: biological_process alt_id: GO:0070261 def: "The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:mtg_heart, ISBN:0192800825] subset: goslim_pir synonym: "hemolymph circulation" RELATED [] is_a: GO:0003013 ! circulatory system process [Term] id: GO:0008016 name: regulation of heart contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "regulation of cardiac contraction" EXACT [] is_a: GO:1903522 ! regulation of blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0060047 ! heart contraction relationship: regulates GO:0060047 ! heart contraction [Term] id: GO:0008104 name: protein localization namespace: biological_process alt_id: GO:0008105 def: "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] synonym: "asymmetric protein localisation" RELATED [GOC:mah] synonym: "asymmetric protein localization" RELATED [] synonym: "establishment and maintenance of asymmetric protein localization" RELATED [] synonym: "establishment and maintenance of protein localization" RELATED [] synonym: "protein localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization [Term] id: GO:0008150 name: biological_process namespace: biological_process alt_id: GO:0000004 alt_id: GO:0007582 alt_id: GO:0044699 def: "A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt] comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast synonym: "biological process" EXACT [] synonym: "physiological process" EXACT [] synonym: "single organism process" RELATED [] synonym: "single-organism process" RELATED [] xref: Wikipedia:Biological_process is_a: BFO:0000015 ! process created_by: jl creation_date: 2012-09-19T15:05:24Z [Term] id: GO:0008152 name: metabolic process namespace: biological_process alt_id: GO:0044236 alt_id: GO:0044710 def: "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions. subset: gocheck_do_not_manually_annotate subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "metabolic process resulting in cell growth" NARROW [] synonym: "metabolism" EXACT [] synonym: "metabolism resulting in cell growth" NARROW [] synonym: "multicellular organism metabolic process" NARROW [] synonym: "single-organism metabolic process" RELATED [] xref: Wikipedia:Metabolism is_a: GO:0008150 ! biological_process created_by: jl creation_date: 2012-10-17T15:46:40Z [Term] id: GO:0008213 name: protein alkylation namespace: biological_process def: "The addition of an alkyl group to a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom." [GOC:ma] subset: goslim_yeast synonym: "protein amino acid alkylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0008219 name: cell death namespace: biological_process def: "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395] comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term. subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_mouse subset: goslim_plant synonym: "accidental cell death" RELATED [] synonym: "necrosis" RELATED [] is_a: GO:0009987 ! cellular process [Term] id: GO:0008233 name: peptidase activity namespace: molecular_function alt_id: GO:0070010 alt_id: GO:0070011 def: "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast synonym: "hydrolase, acting on peptide bonds" EXACT [] synonym: "peptidase activity, acting on D-amino acid peptides" NARROW [] synonym: "peptidase activity, acting on L-amino acid peptides" NARROW [] synonym: "peptide hydrolase activity" EXACT [] synonym: "protease activity" EXACT [] synonym: "proteinase activity" NARROW [] xref: EC:3.4.-.- xref: Reactome:R-HSA-205112 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6" xref: Reactome:R-HSA-3000243 "Unknown protease degrades GIF:Cbl to release Cbl" xref: Reactome:R-HSA-3065958 "An unknown protease degrades ACACA" xref: Reactome:R-HSA-3065959 "An unknown protease degrades hCBXs" xref: Reactome:R-HSA-3139027 "Maturation of HIV Virion" xref: Reactome:R-HSA-376149 "Proteolytic processing of SLIT" xref: Reactome:R-HSA-4167501 "An unknown protease degrades ACACB" xref: Reactome:R-HSA-448678 "CTSG cleaves CASP1(1-404)" xref: Reactome:R-HSA-5655483 "USP1 autocleavage" xref: Reactome:R-HSA-5684864 "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB" xref: Reactome:R-HSA-5685902 "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC" xref: Reactome:R-HSA-5693319 "CTRC hydrolyses PRSS1" xref: Reactome:R-HSA-6803060 "DCD(63-110) is processed to DCD(63-109)" is_a: GO:0016787 ! hydrolase activity is_a: GO:0140096 ! catalytic activity, acting on a protein relationship: part_of GO:0006508 ! proteolysis [Term] id: GO:0008234 name: cysteine-type peptidase activity namespace: molecular_function alt_id: GO:0004220 def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE] synonym: "cysteine protease activity" NARROW [] synonym: "thiol protease activity" NARROW [] xref: Reactome:R-HSA-2022381 "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)" xref: Reactome:R-HSA-2467775 "Autocleavage of ESPL1 (Separase)" xref: Reactome:R-HSA-2467809 "ESPL1 (Separase) cleaves centromeric cohesin" xref: Reactome:R-HSA-5660752 "USP9X deubiquitinates Ub-SNCA" is_a: GO:0008233 ! peptidase activity [Term] id: GO:0008283 name: cell population proliferation namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] comment: This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms. subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir synonym: "cell proliferation" RELATED [] is_a: GO:0009987 ! cellular process property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0008284 name: positive regulation of cell population proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] synonym: "activation of cell proliferation" NARROW [] synonym: "positive regulation of cell proliferation" RELATED [] synonym: "stimulation of cell proliferation" NARROW [] synonym: "up regulation of cell proliferation" EXACT [] synonym: "up-regulation of cell proliferation" EXACT [] synonym: "upregulation of cell proliferation" EXACT [] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0008283 ! cell population proliferation relationship: positively_regulates GO:0008283 ! cell population proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0008285 name: negative regulation of cell population proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] synonym: "down regulation of cell proliferation" EXACT [] synonym: "down-regulation of cell proliferation" EXACT [] synonym: "downregulation of cell proliferation" EXACT [] synonym: "inhibition of cell proliferation" NARROW [] synonym: "negative regulation of cell proliferation" RELATED [] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0008283 ! cell population proliferation relationship: negatively_regulates GO:0008283 ! cell population proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0008286 name: insulin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb] synonym: "daf-2 receptor signaling pathway" NARROW [] synonym: "insulin receptor signalling pathway" EXACT [] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway relationship: part_of GO:0032869 ! cellular response to insulin stimulus [Term] id: GO:0008361 name: regulation of cell size namespace: biological_process def: "Any process that modulates the size of a cell." [GOC:go_curators] synonym: "cell size control" EXACT [] is_a: GO:0032535 ! regulation of cellular component size [Term] id: GO:0008543 name: fibroblast growth factor receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GOC:ceb] synonym: "FGF receptor signaling pathway" EXACT [] synonym: "FGF receptor signalling pathway" EXACT [] synonym: "FGFR signaling pathway" EXACT [] synonym: "fibroblast growth factor receptor signalling pathway" EXACT [] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway relationship: part_of GO:0044344 ! cellular response to fibroblast growth factor stimulus [Term] id: GO:0009058 name: biosynthetic process namespace: biological_process alt_id: GO:0044274 alt_id: GO:0044711 def: "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant synonym: "anabolism" EXACT [] synonym: "biosynthesis" EXACT [] synonym: "formation" BROAD [] synonym: "multicellular organismal biosynthetic process" NARROW [] synonym: "single-organism biosynthetic process" RELATED [] synonym: "synthesis" EXACT [] xref: Wikipedia:Anabolism is_a: GO:0008152 ! metabolic process created_by: jl creation_date: 2012-10-17T15:52:18Z [Term] id: GO:0009059 name: macromolecule biosynthetic process namespace: biological_process alt_id: GO:0043284 def: "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] subset: goslim_pir synonym: "biopolymer biosynthetic process" EXACT [GOC:mtg_chebi_dec09] synonym: "macromolecule anabolism" EXACT [] synonym: "macromolecule biosynthesis" EXACT [] synonym: "macromolecule formation" EXACT [] synonym: "macromolecule synthesis" EXACT [] is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:0009314 name: response to radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation] comment: Note that 'radiation' refers to electromagnetic radiation of any wavelength. synonym: "response to electromagnetic radiation stimulus" EXACT [] synonym: "response to radiation stimulus" EXACT [] is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009416 name: response to light stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089] subset: goslim_plant is_a: GO:0009314 ! response to radiation [Term] id: GO:0009566 name: fertilization namespace: biological_process def: "The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:tb, ISBN:0198506732] synonym: "syngamy" EXACT [] xref: Wikipedia:Fertilisation is_a: GO:0022414 ! reproductive process relationship: part_of GO:0019953 ! sexual reproduction property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/20176 xsd:anyURI [Term] id: GO:0009605 name: response to external stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_drosophila subset: goslim_plant synonym: "response to environmental stimulus" EXACT [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009611 name: response to wounding namespace: biological_process alt_id: GO:0002245 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism." [GOC:go_curators] synonym: "physiological response to wounding" EXACT [] is_a: GO:0006950 ! response to stress [Term] id: GO:0009612 name: response to mechanical stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb] synonym: "chemi-mechanical coupling" RELATED [] synonym: "mechanical stimulus response" EXACT [] is_a: GO:0009605 ! response to external stimulus is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009628 name: response to abiotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_metagenomics subset: goslim_plant synonym: "response to abiotic stress" NARROW [] is_a: GO:0050896 ! response to stimulus property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/16572 xsd:anyURI [Term] id: GO:0009653 name: anatomical structure morphogenesis namespace: biological_process def: "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125] synonym: "anatomical structure organization" EXACT [] synonym: "embryogenesis and morphogenesis" BROAD [] synonym: "morphogenesis" EXACT [] xref: Wikipedia:Morphogenesis is_a: GO:0032502 ! developmental process relationship: part_of GO:0048856 ! anatomical structure development [Term] id: GO:0009719 name: response to endogenous stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_plant is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009725 name: response to hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl] synonym: "growth regulator" RELATED [] synonym: "response to hormone stimulus" EXACT [GOC:dos] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0010033 ! response to organic substance [Term] id: GO:0009726 name: detection of endogenous stimulus namespace: biological_process def: "The series of events in which an endogenous stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of endogenous stimulus" RELATED [] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009790 name: embryo development namespace: biological_process alt_id: GO:0009795 def: "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] subset: gocheck_do_not_manually_annotate subset: goslim_chembl subset: goslim_generic subset: goslim_plant synonym: "embryogenesis" EXACT [] synonym: "embryogenesis and morphogenesis" BROAD [] synonym: "embryonal development" EXACT [] xref: Wikipedia:Embryogenesis is_a: GO:0007275 ! multicellular organism development [Term] id: GO:0009792 name: embryo development ending in birth or egg hatching namespace: biological_process def: "The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] synonym: "embryogenesis" BROAD [] is_a: GO:0009790 ! embryo development [Term] id: GO:0009798 name: axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of a pattern along a line or around a point." [GOC:dph, GOC:go_curators, GOC:isa_complete] synonym: "axis determination" RELATED [] is_a: GO:0007389 ! pattern specification process [Term] id: GO:0009799 name: specification of symmetry namespace: biological_process def: "The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created." [GOC:go_curators] synonym: "determination of symmetry" EXACT [GOC:dph] is_a: GO:0007389 ! pattern specification process [Term] id: GO:0009855 name: determination of bilateral symmetry namespace: biological_process def: "The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:go_curators] synonym: "determination of bilateral asymmetry" EXACT [GOC:dph] is_a: GO:0009799 ! specification of symmetry [Term] id: GO:0009887 name: animal organ morphogenesis namespace: biological_process def: "Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544] synonym: "histogenesis and organogenesis" BROAD [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048513 ! animal organ development [Term] id: GO:0009888 name: tissue development namespace: biological_process def: "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208] synonym: "histogenesis" EXACT [] synonym: "histogenesis and organogenesis" BROAD [] xref: Wikipedia:Histogenesis is_a: GO:0048856 ! anatomical structure development property_value: RO:0002161 NCBITaxon:147554 property_value: RO:0002161 NCBITaxon:33630 property_value: RO:0002161 NCBITaxon:33682 property_value: RO:0002161 NCBITaxon:38254 property_value: RO:0002161 NCBITaxon:4891 [Term] id: GO:0009889 name: regulation of biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] synonym: "regulation of anabolism" EXACT [] synonym: "regulation of biosynthesis" EXACT [] synonym: "regulation of formation" EXACT [] synonym: "regulation of synthesis" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009058 ! biosynthetic process relationship: regulates GO:0009058 ! biosynthetic process [Term] id: GO:0009890 name: negative regulation of biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] synonym: "down regulation of biosynthetic process" EXACT [] synonym: "down-regulation of biosynthetic process" EXACT [] synonym: "downregulation of biosynthetic process" EXACT [] synonym: "inhibition of biosynthetic process" NARROW [] synonym: "negative regulation of anabolism" EXACT [] synonym: "negative regulation of biosynthesis" EXACT [] synonym: "negative regulation of formation" EXACT [] synonym: "negative regulation of synthesis" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0009892 ! negative regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009058 ! biosynthetic process relationship: negatively_regulates GO:0009058 ! biosynthetic process [Term] id: GO:0009891 name: positive regulation of biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] synonym: "activation of biosynthetic process" NARROW [] synonym: "positive regulation of anabolism" EXACT [] synonym: "positive regulation of biosynthesis" EXACT [] synonym: "positive regulation of formation" EXACT [] synonym: "positive regulation of synthesis" EXACT [] synonym: "stimulation of biosynthetic process" NARROW [] synonym: "up regulation of biosynthetic process" EXACT [] synonym: "up-regulation of biosynthetic process" EXACT [] synonym: "upregulation of biosynthetic process" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0009893 ! positive regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009058 ! biosynthetic process relationship: positively_regulates GO:0009058 ! biosynthetic process [Term] id: GO:0009892 name: negative regulation of metabolic process namespace: biological_process alt_id: GO:0044252 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] synonym: "down regulation of metabolic process" EXACT [] synonym: "down-regulation of metabolic process" EXACT [] synonym: "downregulation of metabolic process" EXACT [] synonym: "inhibition of metabolic process" NARROW [] synonym: "inhibition of organismal metabolic process" NARROW [] synonym: "negative regulation of metabolism" EXACT [] synonym: "negative regulation of multicellular organismal metabolic process" NARROW [] synonym: "negative regulation of organismal metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0008152 ! metabolic process relationship: negatively_regulates GO:0008152 ! metabolic process [Term] id: GO:0009893 name: positive regulation of metabolic process namespace: biological_process alt_id: GO:0044253 def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] synonym: "activation of metabolic process" NARROW [] synonym: "positive regulation of metabolism" EXACT [] synonym: "positive regulation of multicellular organismal metabolic process" NARROW [] synonym: "positive regulation of organismal metabolism" NARROW [] synonym: "stimulation of metabolic process" NARROW [] synonym: "stimulation of organismal metabolic process" NARROW [] synonym: "up regulation of metabolic process" EXACT [] synonym: "up-regulation of metabolic process" EXACT [] synonym: "up-regulation of organismal metabolic process" NARROW [] synonym: "upregulation of metabolic process" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0008152 ! metabolic process relationship: positively_regulates GO:0008152 ! metabolic process [Term] id: GO:0009946 name: proximal/distal axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end)." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "proximal/distal axis determination" RELATED [GOC:dph] synonym: "proximodistal axis specification" EXACT [] is_a: GO:0009798 ! axis specification relationship: part_of GO:0009954 ! proximal/distal pattern formation [Term] id: GO:0009948 name: anterior/posterior axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "anterior/posterior axis determination" RELATED [GOC:dph] is_a: GO:0009798 ! axis specification relationship: part_of GO:0009952 ! anterior/posterior pattern specification [Term] id: GO:0009950 name: dorsal/ventral axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "dorsal-ventral axis specification" EXACT [GOC:mah] synonym: "dorsal/ventral axis determination" RELATED [GOC:dph] synonym: "dorsoventral axis specification" EXACT [GOC:mah] is_a: GO:0009798 ! axis specification relationship: part_of GO:0009953 ! dorsal/ventral pattern formation [Term] id: GO:0009952 name: anterior/posterior pattern specification namespace: biological_process def: "The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] synonym: "anterior/posterior pattern formation" RELATED [] is_a: GO:0003002 ! regionalization [Term] id: GO:0009953 name: dorsal/ventral pattern formation namespace: biological_process def: "The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] synonym: "dorsal-ventral pattern formation" EXACT [GOC:mah] synonym: "dorsal/ventral pattern specification" NARROW [] synonym: "dorsoventral pattern formation" EXACT [GOC:mah] is_a: GO:0003002 ! regionalization [Term] id: GO:0009954 name: proximal/distal pattern formation namespace: biological_process def: "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end)." [GOC:dph, GOC:go_curators, GOC:isa_complete] synonym: "proximal/distal pattern specification" NARROW [] is_a: GO:0003002 ! regionalization [Term] id: GO:0009966 name: regulation of signal transduction namespace: biological_process alt_id: GO:0035466 def: "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm] synonym: "regulation of signaling pathway" RELATED [] synonym: "regulation of signalling pathway" RELATED [GOC:mah] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0023051 ! regulation of signaling is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007165 ! signal transduction relationship: regulates GO:0007165 ! signal transduction [Term] id: GO:0009967 name: positive regulation of signal transduction namespace: biological_process alt_id: GO:0035468 def: "Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm] synonym: "activation of signal transduction" NARROW [] synonym: "positive regulation of signaling pathway" RELATED [] synonym: "positive regulation of signalling pathway" RELATED [GOC:mah] synonym: "stimulation of signal transduction" NARROW [] synonym: "up regulation of signal transduction" EXACT [] synonym: "up-regulation of signal transduction" EXACT [] synonym: "upregulation of signal transduction" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007165 ! signal transduction relationship: positively_regulates GO:0007165 ! signal transduction [Term] id: GO:0009968 name: negative regulation of signal transduction namespace: biological_process alt_id: GO:0035467 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm] synonym: "down regulation of signal transduction" EXACT [] synonym: "down-regulation of signal transduction" EXACT [] synonym: "downregulation of signal transduction" EXACT [] synonym: "inhibition of signal transduction" NARROW [] synonym: "negative regulation of signaling pathway" RELATED [] synonym: "negative regulation of signalling pathway" RELATED [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0023057 ! negative regulation of signaling is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007165 ! signal transduction relationship: negatively_regulates GO:0007165 ! signal transduction [Term] id: GO:0009987 name: cellular process namespace: biological_process alt_id: GO:0008151 alt_id: GO:0044763 alt_id: GO:0050875 def: "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] subset: goslim_plant synonym: "cell growth and/or maintenance" NARROW [] synonym: "cell physiology" EXACT [] synonym: "cellular physiological process" EXACT [] synonym: "single-organism cellular process" RELATED [] is_a: GO:0008150 ! biological_process created_by: jl creation_date: 2012-12-11T16:56:55Z [Term] id: GO:0010033 name: response to organic substance namespace: biological_process alt_id: GO:1990367 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm, PMID:23356676] synonym: "process resulting in tolerance to organic substance" NARROW [] is_a: GO:0042221 ! response to chemical [Term] id: GO:0010243 name: response to organonitrogen compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond." [PMID:9869419] synonym: "response to organic nitrogen" EXACT [] is_a: GO:0010033 ! response to organic substance is_a: GO:1901698 ! response to nitrogen compound [Term] id: GO:0010466 name: negative regulation of peptidase activity namespace: biological_process def: "Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb] is_a: GO:0045861 ! negative regulation of proteolysis is_a: GO:0051346 ! negative regulation of hydrolase activity is_a: GO:0052547 ! regulation of peptidase activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0008233 ! peptidase activity relationship: negatively_regulates GO:0008233 ! peptidase activity [Term] id: GO:0010467 name: gene expression namespace: biological_process def: "The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] subset: goslim_flybase_ribbon xref: Wikipedia:Gene_expression is_a: GO:0043170 ! macromolecule metabolic process [Term] id: GO:0010468 name: regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] comment: This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availability of mRNA or circRNA for translation and thereby regulates the rate of production of the encoded protein via translation. synonym: "regulation of gene product expression" RELATED [] synonym: "regulation of protein expression" NARROW [] xref: Wikipedia:Regulation_of_gene_expression is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0010467 ! gene expression relationship: regulates GO:0010467 ! gene expression [Term] id: GO:0010470 name: regulation of gastrulation namespace: biological_process def: "Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals." [GOC:dph, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0045995 ! regulation of embryonic development intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007369 ! gastrulation relationship: regulates GO:0007369 ! gastrulation [Term] id: GO:0010556 name: regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009059 ! macromolecule biosynthetic process relationship: regulates GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0010557 name: positive regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0010604 ! positive regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009059 ! macromolecule biosynthetic process relationship: positively_regulates GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0010558 name: negative regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0010605 ! negative regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009059 ! macromolecule biosynthetic process relationship: negatively_regulates GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0010562 name: positive regulation of phosphorus metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0051174 ! regulation of phosphorus metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006793 ! phosphorus metabolic process relationship: positively_regulates GO:0006793 ! phosphorus metabolic process [Term] id: GO:0010563 name: negative regulation of phosphorus metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0051174 ! regulation of phosphorus metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006793 ! phosphorus metabolic process relationship: negatively_regulates GO:0006793 ! phosphorus metabolic process [Term] id: GO:0010564 name: regulation of cell cycle process namespace: biological_process def: "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0022402 ! cell cycle process relationship: regulates GO:0022402 ! cell cycle process [Term] id: GO:0010604 name: positive regulation of macromolecule metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0043170 ! macromolecule metabolic process relationship: positively_regulates GO:0043170 ! macromolecule metabolic process [Term] id: GO:0010605 name: negative regulation of macromolecule metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0043170 ! macromolecule metabolic process relationship: negatively_regulates GO:0043170 ! macromolecule metabolic process [Term] id: GO:0010623 name: programmed cell death involved in cell development namespace: biological_process def: "The activation of endogenous cellular processes that result in the death of a cell as part of its development." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] comment: This process is part of the natural developmental program of some cell types, but it does not always happen as part of the development or shaping of a gross anatomical structure. synonym: "developmental programmed cell death" BROAD [] synonym: "programmed cell death involved in development" BROAD [] is_a: GO:0012501 ! programmed cell death is_a: GO:0048869 ! cellular developmental process intersection_of: GO:0012501 ! programmed cell death intersection_of: part_of GO:0048468 ! cell development relationship: part_of GO:0048468 ! cell development [Term] id: GO:0010628 name: positive regulation of gene expression namespace: biological_process def: "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0010604 ! positive regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0010467 ! gene expression relationship: positively_regulates GO:0010467 ! gene expression [Term] id: GO:0010629 name: negative regulation of gene expression namespace: biological_process def: "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] comment: This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation. is_a: GO:0010468 ! regulation of gene expression is_a: GO:0010605 ! negative regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0010467 ! gene expression relationship: negatively_regulates GO:0010467 ! gene expression [Term] id: GO:0010638 name: positive regulation of organelle organization namespace: biological_process def: "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] synonym: "positive regulation of organelle organisation" EXACT [GOC:mah] synonym: "positive regulation of organelle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006996 ! organelle organization relationship: positively_regulates GO:0006996 ! organelle organization [Term] id: GO:0010639 name: negative regulation of organelle organization namespace: biological_process def: "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] synonym: "negative regulation of organelle organisation" EXACT [GOC:mah] synonym: "negative regulation of organelle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006996 ! organelle organization relationship: negatively_regulates GO:0006996 ! organelle organization [Term] id: GO:0010646 name: regulation of cell communication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007154 ! cell communication relationship: regulates GO:0007154 ! cell communication [Term] id: GO:0010647 name: positive regulation of cell communication namespace: biological_process def: "Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007154 ! cell communication relationship: positively_regulates GO:0007154 ! cell communication [Term] id: GO:0010648 name: negative regulation of cell communication namespace: biological_process def: "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007154 ! cell communication relationship: negatively_regulates GO:0007154 ! cell communication [Term] id: GO:0010672 name: regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle namespace: biological_process alt_id: GO:1900401 def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle." [GOC:dph, GOC:tb, PMID:12161753] synonym: "regulation of meiosis by regulation of transcription from RNA polymerase II promoter" NARROW [] synonym: "regulation of transcription from RNA polymerase II promoter, meiotic" EXACT [GOC:mah] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0051037 ! regulation of transcription involved in meiotic cell cycle intersection_of: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: part_of GO:0051321 ! meiotic cell cycle created_by: mah creation_date: 2012-04-20T02:45:12Z [Term] id: GO:0010673 name: positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle namespace: biological_process alt_id: GO:1900476 def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle." [GOC:dph, GOC:tb, PMID:8618927] synonym: "activation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "positive regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [] synonym: "positive regulation of transcription from RNA polymerase II promoter, meiotic" EXACT [GOC:mah] synonym: "stimulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "up regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "up-regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "upregulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] is_a: GO:0010672 ! regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:0051039 ! positive regulation of transcription involved in meiotic cell cycle intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: part_of GO:0051321 ! meiotic cell cycle created_by: dgf creation_date: 2012-05-01T08:40:11Z [Term] id: GO:0010674 name: negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle namespace: biological_process alt_id: GO:1900475 def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle." [GOC:dph, GOC:tb, PMID:8618927] synonym: "activation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "negative regulation of transcription from RNA polymerase II promoter, meiotic" EXACT [GOC:mah] synonym: "positive regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [] synonym: "stimulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "up regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "up-regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "upregulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:0010672 ! regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle is_a: GO:0051038 ! negative regulation of transcription involved in meiotic cell cycle intersection_of: GO:0000122 ! negative regulation of transcription by RNA polymerase II intersection_of: part_of GO:0051321 ! meiotic cell cycle created_by: dgf creation_date: 2012-05-01T08:39:58Z [Term] id: GO:0010720 name: positive regulation of cell development namespace: biological_process def: "Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0048468 ! cell development relationship: positively_regulates GO:0048468 ! cell development [Term] id: GO:0010721 name: negative regulation of cell development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0048468 ! cell development relationship: negatively_regulates GO:0048468 ! cell development [Term] id: GO:0010769 name: regulation of cell morphogenesis involved in differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb] is_a: GO:0022604 ! regulation of cell morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0000904 ! cell morphogenesis involved in differentiation relationship: regulates GO:0000904 ! cell morphogenesis involved in differentiation [Term] id: GO:0010770 name: positive regulation of cell morphogenesis involved in differentiation namespace: biological_process def: "Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0000904 ! cell morphogenesis involved in differentiation relationship: positively_regulates GO:0000904 ! cell morphogenesis involved in differentiation [Term] id: GO:0010771 name: negative regulation of cell morphogenesis involved in differentiation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0000904 ! cell morphogenesis involved in differentiation relationship: negatively_regulates GO:0000904 ! cell morphogenesis involved in differentiation [Term] id: GO:0010817 name: regulation of hormone levels namespace: biological_process def: "Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0010862 name: positive regulation of pathway-restricted SMAD protein phosphorylation namespace: biological_process def: "Any process that increases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:dph, GOC:tb] is_a: GO:0001934 ! positive regulation of protein phosphorylation is_a: GO:0060393 ! regulation of pathway-restricted SMAD protein phosphorylation is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0060389 ! pathway-restricted SMAD protein phosphorylation relationship: positively_regulates GO:0060389 ! pathway-restricted SMAD protein phosphorylation [Term] id: GO:0010927 name: cellular component assembly involved in morphogenesis namespace: biological_process def: "The cellular component assembly that is part of the initial shaping of the component during its developmental progression." [GOC:dph, GOC:tb] is_a: GO:0022607 ! cellular component assembly is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0022607 ! cellular component assembly intersection_of: part_of GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0032989 ! cellular component morphogenesis [Term] id: GO:0010941 name: regulation of cell death namespace: biological_process def: "Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0008219 ! cell death relationship: regulates GO:0008219 ! cell death [Term] id: GO:0010942 name: positive regulation of cell death namespace: biological_process def: "Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:dph, GOC:tb] is_a: GO:0010941 ! regulation of cell death is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0008219 ! cell death relationship: positively_regulates GO:0008219 ! cell death [Term] id: GO:0010948 name: negative regulation of cell cycle process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0045786 ! negative regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0022402 ! cell cycle process relationship: negatively_regulates GO:0022402 ! cell cycle process created_by: tb creation_date: 2009-04-27T09:53:22Z [Term] id: GO:0010950 name: positive regulation of endopeptidase activity namespace: biological_process def: "Any process that increases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb] is_a: GO:0010952 ! positive regulation of peptidase activity is_a: GO:0052548 ! regulation of endopeptidase activity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0004175 ! endopeptidase activity relationship: positively_regulates GO:0004175 ! endopeptidase activity created_by: tb creation_date: 2009-04-27T11:45:39Z [Term] id: GO:0010951 name: negative regulation of endopeptidase activity namespace: biological_process def: "Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb] subset: goslim_chembl is_a: GO:0010466 ! negative regulation of peptidase activity is_a: GO:0052548 ! regulation of endopeptidase activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0004175 ! endopeptidase activity relationship: negatively_regulates GO:0004175 ! endopeptidase activity created_by: tb creation_date: 2009-04-27T11:47:01Z [Term] id: GO:0010952 name: positive regulation of peptidase activity namespace: biological_process def: "Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb] is_a: GO:0045862 ! positive regulation of proteolysis is_a: GO:0051345 ! positive regulation of hydrolase activity is_a: GO:0052547 ! regulation of peptidase activity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0008233 ! peptidase activity relationship: positively_regulates GO:0008233 ! peptidase activity created_by: tb creation_date: 2009-04-27T11:54:32Z [Term] id: GO:0010959 name: regulation of metal ion transport namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of metal ion transport. Metal ion transport is the directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0043269 ! regulation of ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0030001 ! metal ion transport relationship: regulates GO:0030001 ! metal ion transport created_by: tb creation_date: 2009-05-06T11:40:55Z [Term] id: GO:0010970 name: transport along microtubule namespace: biological_process def: "The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity." [GOC:dph, GOC:mah, GOC:tb] synonym: "establishment of localization by movement along microtubule" EXACT [GOC:dph] synonym: "microtubule-based transport" BROAD [] synonym: "movement along microtubule" EXACT [] is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport is_a: GO:0099111 ! microtubule-based transport created_by: tb creation_date: 2009-05-27T10:56:08Z [Term] id: GO:0010975 name: regulation of neuron projection development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb] synonym: "regulation of neurite biosynthesis" NARROW [GOC:mah] synonym: "regulation of neurite development" NARROW [GOC:mah] synonym: "regulation of neurite formation" NARROW [GOC:mah] synonym: "regulation of neurite growth" NARROW [GOC:mah] is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0031175 ! neuron projection development relationship: regulates GO:0031175 ! neuron projection development created_by: tb creation_date: 2009-06-01T10:44:45Z [Term] id: GO:0010976 name: positive regulation of neuron projection development namespace: biological_process def: "Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb] synonym: "positive regulation of neurite biosynthesis" NARROW [GOC:mah] synonym: "positive regulation of neurite development" NARROW [GOC:mah] synonym: "positive regulation of neurite formation" NARROW [GOC:mah] synonym: "positive regulation of neurite growth" NARROW [GOC:mah] is_a: GO:0010975 ! regulation of neuron projection development is_a: GO:0031346 ! positive regulation of cell projection organization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0031175 ! neuron projection development relationship: positively_regulates GO:0031175 ! neuron projection development created_by: tb creation_date: 2009-06-01T10:46:44Z [Term] id: GO:0010977 name: negative regulation of neuron projection development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb] synonym: "growth cone collapse" RELATED [GOC:pr] synonym: "negative regulation of neurite biosynthesis" NARROW [GOC:mah] synonym: "negative regulation of neurite development" NARROW [GOC:mah] synonym: "negative regulation of neurite formation" NARROW [GOC:mah] synonym: "negative regulation of neurite growth" NARROW [GOC:mah] is_a: GO:0010975 ! regulation of neuron projection development is_a: GO:0031345 ! negative regulation of cell projection organization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0031175 ! neuron projection development relationship: negatively_regulates GO:0031175 ! neuron projection development created_by: tb creation_date: 2009-06-01T10:47:42Z [Term] id: GO:0012501 name: programmed cell death namespace: biological_process alt_id: GO:0016244 def: "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] comment: Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children. synonym: "caspase-independent apoptosis" RELATED [] synonym: "caspase-independent cell death" NARROW [] synonym: "non-apoptotic programmed cell death" NARROW [] synonym: "nonapoptotic programmed cell death" NARROW [] synonym: "PCD" RELATED [] synonym: "RCD" RELATED [] synonym: "regulated cell death" BROAD [] xref: Wikipedia:Programmed_cell_death is_a: GO:0008219 ! cell death [Term] id: GO:0012505 name: endomembrane system namespace: cellular_component def: "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] subset: goslim_aspergillus subset: goslim_candida subset: goslim_flybase_ribbon subset: goslim_yeast xref: Wikipedia:Endomembrane_system is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:0005773 ! vacuole relationship: has_part GO:0005886 ! plasma membrane [Term] id: GO:0014020 name: primary neural tube formation namespace: biological_process def: "The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube." [GOC:ef, ISBN:0878932585] synonym: "primary neural tube morphogenesis" EXACT [GOC:dph] synonym: "primary neurulation" EXACT [] is_a: GO:0001838 ! embryonic epithelial tube formation relationship: part_of GO:0001841 ! neural tube formation [Term] id: GO:0014022 name: neural plate elongation namespace: biological_process def: "The process in which the neural plate is shaped by the intrinsic movement of the epidermal and neural plate regions." [GOC:ef, ISBN:0878932585] is_a: GO:0002011 ! morphogenesis of an epithelial sheet is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001839 ! neural plate morphogenesis [Term] id: GO:0014807 name: regulation of somitogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of somitogenesis." [GOC:mtg_muscle] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0001756 ! somitogenesis relationship: regulates GO:0001756 ! somitogenesis [Term] id: GO:0015031 name: protein transport namespace: biological_process alt_id: GO:0015831 def: "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_yeast synonym: "enzyme transport" NARROW [] is_a: GO:0015833 ! peptide transport is_a: GO:0045184 ! establishment of protein localization [Term] id: GO:0015629 name: actin cytoskeleton namespace: cellular_component def: "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] subset: goslim_aspergillus is_a: GO:0005856 ! cytoskeleton [Term] id: GO:0015833 name: peptide transport namespace: biological_process def: "The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir is_a: GO:0042886 ! amide transport is_a: GO:0071702 ! organic substance transport [Term] id: GO:0016020 name: membrane namespace: cellular_component alt_id: GO:0098589 alt_id: GO:0098805 def: "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "membrane region" NARROW [] synonym: "region of membrane" NARROW [] synonym: "whole membrane" NARROW [] xref: Wikipedia:Biological_membrane is_a: GO:0110165 ! cellular anatomical entity creation_date: 2014-03-06T11:37:54Z [Term] id: GO:0016043 name: cellular component organization namespace: biological_process alt_id: GO:0044235 alt_id: GO:0071842 def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah] subset: goslim_agr subset: goslim_mouse subset: goslim_pir subset: goslim_plant synonym: "cell organisation" EXACT [] synonym: "cell organization and biogenesis" RELATED [GOC:mah] synonym: "cellular component organisation at cellular level" EXACT [GOC:mah] synonym: "cellular component organisation in other organism" EXACT [GOC:mah] synonym: "cellular component organization at cellular level" EXACT [] synonym: "cellular component organization in other organism" EXACT [] is_a: GO:0071840 ! cellular component organization or biogenesis [Term] id: GO:0016049 name: cell growth namespace: biological_process alt_id: GO:0048591 def: "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai] subset: gocheck_do_not_annotate subset: goslim_drosophila subset: goslim_pir subset: goslim_plant synonym: "cell expansion" RELATED [] synonym: "cellular growth" EXACT [] synonym: "growth of cell" EXACT [] synonym: "metabolic process resulting in cell growth" RELATED [] synonym: "metabolism resulting in cell growth" RELATED [] synonym: "non-developmental cell growth" RELATED [GOC:mah] synonym: "non-developmental growth of a unicellular organism" RELATED [GOC:mah] is_a: GO:0009987 ! cellular process is_a: GO:0040007 ! growth [Term] id: GO:0016055 name: Wnt signaling pathway namespace: biological_process alt_id: GO:0007222 def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] synonym: "frizzled signaling pathway" EXACT [] synonym: "frizzled signalling pathway" EXACT [] synonym: "Wg signaling pathway" EXACT [GOC:sart, PMID:8080429] synonym: "Wg signalling pathway" EXACT [GOC:sart, PMID:8080429] synonym: "Wingless signaling pathway" EXACT [GOC:sart, PMID:8080429] synonym: "Wingless signalling pathway" EXACT [GOC:sart, PMID:8080429] synonym: "Wnt receptor signaling pathway" EXACT [GOC:signaling] synonym: "Wnt receptor signalling pathway" EXACT [] synonym: "Wnt-activated signaling pathway" RELATED [] is_a: GO:1905114 ! cell surface receptor signaling pathway involved in cell-cell signaling relationship: part_of GO:0198738 ! cell-cell signaling by wnt [Term] id: GO:0016070 name: RNA metabolic process namespace: biological_process def: "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_metagenomics subset: goslim_pir synonym: "RNA metabolism" EXACT [] is_a: GO:0090304 ! nucleic acid metabolic process [Term] id: GO:0016192 name: vesicle-mediated transport namespace: biological_process alt_id: GO:0006899 def: "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe synonym: "nonselective vesicle transport" NARROW [] synonym: "protein sorting along secretory pathway" RELATED [] synonym: "vesicle trafficking" RELATED [] synonym: "vesicle transport" EXACT [] synonym: "vesicular transport" EXACT [GOC:mah] is_a: GO:0006810 ! transport is_a: GO:0009987 ! cellular process [Term] id: GO:0016301 name: kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] comment: Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant subset: goslim_yeast synonym: "phosphokinase activity" EXACT [] xref: Reactome:R-HSA-6788855 "FN3KRP phosphorylates PsiAm, RibAm" xref: Reactome:R-HSA-6788867 "FN3K phosphorylates ketosamines" is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups relationship: part_of GO:0016310 ! phosphorylation [Term] id: GO:0016310 name: phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] subset: goslim_chembl subset: goslim_metagenomics xref: Wikipedia:Phosphorylation is_a: GO:0006796 ! phosphate-containing compound metabolic process [Term] id: GO:0016331 name: morphogenesis of embryonic epithelium namespace: biological_process def: "The process in which the anatomical structures of embryonic epithelia are generated and organized." [GOC:jl] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0048598 ! embryonic morphogenesis [Term] id: GO:0016477 name: cell migration namespace: biological_process def: "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration] xref: Wikipedia:Cell_migration is_a: GO:0048870 ! cell motility [Term] id: GO:0016491 name: oxidoreductase activity namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_yeast synonym: "oxidoreductase activity, acting on other substrates" NARROW [] synonym: "redox activity" EXACT [] xref: EC:1.-.-.- xref: Reactome:R-HSA-1614362 "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases" xref: Reactome:R-HSA-209921 "Monoiodinated tyrosine can be deiodinated" xref: Reactome:R-HSA-209960 "Diiodinated tyrosine can be deiodinated" xref: Reactome:R-HSA-3095889 "MMACHC reduces Cbl" xref: Reactome:R-HSA-390425 "FAR1 reduces PalmCoA to HXOL" xref: Reactome:R-HSA-390438 "FAR2 reduces PalmCoA to HXOL" xref: Reactome:R-HSA-5662660 "Dopachrome is transformed to DHICA by DCT" xref: Reactome:R-HSA-8878581 "TYRP1 oxidises DHICA to IQCA" xref: Reactome:R-HSA-8936442 "MARC1,MARC2 reduce N-hydroxylated compounds" xref: Reactome:R-HSA-9020249 "Hydroperoxy reductase reduces 4(S)-Hp-17(S)-HDHA to RvD6" xref: Reactome:R-HSA-9020260 "Hydroperoxy reducatse reduces 7(S)-Hp-17(S)-HDHA to RvD5" xref: Reactome:R-HSA-9024624 "Hydroperoxy reductase reduces 4(S)-Hp-17(R)-HDHA to AT-RvD6" xref: Reactome:R-HSA-9024630 "Hydroperoxy reductase reduces 7(S)-Hp-17(R)-HDHA to AT-RvD5" xref: Reactome:R-HSA-9025007 "Hydroperoxy reductase reduces 7(S),14(S)-diHp-DHA to 7-epi-MaR1" xref: Reactome:R-HSA-9026001 "Hydroperoxy reductase reduces 7,17-diHp-DPAn-3 to RvD5n-3DPA" xref: Reactome:R-HSA-9026917 "Lipoxygenase dehydrogenates 7(S),17(S)-diHp-DHA to 7S(8)-epoxy-17(S)-HDHA" xref: Reactome:R-HSA-9027033 "Hydroperoxy reducatase reduces 14(S)-Hp-DHA to 14(S)-HDHA" xref: Reactome:R-HSA-9693722 "Unknown sepiapterin synthase transforms PTHP to sepiapterin" xref: RHEA:27453 is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016569 name: covalent chromatin modification namespace: biological_process def: "The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups." [GOC:mah, GOC:vw] synonym: "chromatin modification" EXACT [] is_a: GO:0006325 ! chromatin organization is_a: GO:0043412 ! macromolecule modification [Term] id: GO:0016570 name: histone modification namespace: biological_process def: "The covalent alteration of one or more amino acid residues within a histone protein." [GOC:krc] subset: goslim_yeast xref: Wikipedia:Histone#Histone_modifications_in_chromatin_regulation is_a: GO:0006464 ! cellular protein modification process is_a: GO:0016569 ! covalent chromatin modification [Term] id: GO:0016571 name: histone methylation namespace: biological_process def: "The modification of histones by addition of methyl groups." [GOC:ai] xref: Wikipedia:Histone_methylation is_a: GO:0006479 ! protein methylation is_a: GO:0016570 ! histone modification [Term] id: GO:0016572 name: histone phosphorylation namespace: biological_process def: "The modification of histones by addition of phosphate groups." [GOC:ai] is_a: GO:0006468 ! protein phosphorylation is_a: GO:0016570 ! histone modification [Term] id: GO:0016614 name: oxidoreductase activity, acting on CH-OH group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] synonym: "oxidoreductase activity, acting on the CH-OH group of donors, other acceptors" NARROW [] xref: EC:1.1.-.- xref: Reactome:R-HSA-1500781 "Fgd1 reactivates F420" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016616 name: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai] synonym: "glycolate reductase" RELATED [EC:1.1.1.26] synonym: "glyoxylic acid reductase" RELATED [] synonym: "NADH-dependent glyoxylate reductase" RELATED [] xref: EC:1.1.1.- xref: Reactome:R-HSA-975629 "RDH11 reduces RBP2:atRAL to RBP2:atROL" is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0016740 name: transferase activity namespace: molecular_function def: "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: EC:2.-.-.- xref: Reactome:R-HSA-1483089 "PE is converted to PS by PTDSS2" xref: Reactome:R-HSA-1483186 "PC is converted to PS by PTDSS1" xref: Reactome:R-HSA-5668414 "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK" xref: Reactome:R-HSA-8868783 "TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016772 name: transferase activity, transferring phosphorus-containing groups namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] comment: Note that this term encompasses all kinase activities, as well as activities that transfer other phosphorus-containing groups such as diphosphate or nucleotides. subset: goslim_chembl xref: EC:2.7.-.- is_a: GO:0016740 ! transferase activity [Term] id: GO:0016773 name: phosphotransferase activity, alcohol group as acceptor namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl] subset: goslim_drosophila xref: EC:2.7.1.- xref: Reactome:R-HSA-2161193 "abacavir + AMP => abacavir monophosphate + adenosine" is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016779 name: nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast xref: EC:2.7.7.- xref: Reactome:R-HSA-6782434 "THG1L transfers GMP to 5' end of tRNA(His)" is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016787 name: hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: EC:3.-.-.- xref: Reactome:R-HSA-1236938 "Partial proteolysis of antigen in phagolysosomes" xref: Reactome:R-HSA-2029475 "Production of AA by iPLA2 upon FCGR activation" xref: Reactome:R-HSA-5694583 "ABHD4 hydrolyses NAPE" xref: Reactome:R-HSA-5695964 "ABHD14B hydrolyses PNPB" xref: Reactome:R-HSA-6786190 "CMBL hydrolyses OM to OLMS" xref: Reactome:R-HSA-6788295 "HDHD1:Mg2+ dephosphorylates PURIDP" xref: Reactome:R-HSA-8938314 "ENPPs hydrolyse CoA-SH to PPANT, PAP" xref: Reactome:R-HSA-8952137 "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0018130 name: heterocycle biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198547684] synonym: "heterocycle anabolism" EXACT [] synonym: "heterocycle biosynthesis" EXACT [] synonym: "heterocycle formation" EXACT [] synonym: "heterocycle synthesis" EXACT [] is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0018193 name: peptidyl-amino acid modification namespace: biological_process def: "The alteration of an amino acid residue in a peptide." [GOC:mah] subset: goslim_yeast is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018205 name: peptidyl-lysine modification namespace: biological_process def: "The modification of peptidyl-lysine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018215 name: protein phosphopantetheinylation namespace: biological_process def: "The modification of a protein amino acid by phosphopantetheinylation." [GOC:ai] synonym: "protein amino acid phosphopantetheinylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018393 name: internal peptidyl-lysine acetylation namespace: biological_process def: "The addition of an acetyl group to a non-terminal lysine residue in a protein." [GOC:mah] is_a: GO:0006475 ! internal protein amino acid acetylation is_a: GO:0018394 ! peptidyl-lysine acetylation [Term] id: GO:0018394 name: peptidyl-lysine acetylation namespace: biological_process def: "The acetylation of peptidyl-lysine." [GOC:mah] is_a: GO:0006473 ! protein acetylation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018958 name: phenol-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [ISBN:0198506732] comment: Note that phenol metabolism is not included as a child of 'xenobiotic metabolism' because although it is synthesized industrially, phenol is also found naturally in animal wastes and other organic materials. It is often formed by the activity of microorganisms, which can chemically modify a variety of xenobiotic and naturally occurring phenolic compounds. synonym: "carbolic acid metabolic process" EXACT [] synonym: "carbolic acid metabolism" EXACT [] synonym: "hydroxybenzene metabolic process" EXACT [] synonym: "hydroxybenzene metabolism" EXACT [] synonym: "phenol-containing compound metabolism" EXACT [] xref: UM-BBD_pathwayID:phe is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0019098 name: reproductive behavior namespace: biological_process alt_id: GO:0033057 alt_id: GO:0044704 def: "The specific behavior of an organism that is associated with reproduction." [GOC:jl, GOC:pr] subset: goslim_drosophila synonym: "multicellular organism reproductive behavior" NARROW [] synonym: "reproductive behavior in a multicellular organism" EXACT [] synonym: "reproductive behaviour" EXACT [] synonym: "single-organism reproductive behavior" RELATED [] is_a: GO:0007610 ! behavior is_a: GO:0048609 ! multicellular organismal reproductive process intersection_of: GO:0007610 ! behavior intersection_of: part_of GO:0000003 ! reproduction created_by: jl creation_date: 2012-09-19T16:01:37Z [Term] id: GO:0019219 name: regulation of nucleobase-containing compound metabolic process namespace: biological_process def: "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006139 ! nucleobase-containing compound metabolic process relationship: regulates GO:0006139 ! nucleobase-containing compound metabolic process [Term] id: GO:0019220 name: regulation of phosphate metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] synonym: "regulation of phosphate metabolism" EXACT [] is_a: GO:0051174 ! regulation of phosphorus metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006796 ! phosphate-containing compound metabolic process relationship: regulates GO:0006796 ! phosphate-containing compound metabolic process [Term] id: GO:0019222 name: regulation of metabolic process namespace: biological_process alt_id: GO:0044246 def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] subset: goslim_metagenomics synonym: "regulation of metabolism" EXACT [] synonym: "regulation of multicellular organismal metabolic process" NARROW [] synonym: "regulation of organismal metabolic process" NARROW [GOC:tb] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0008152 ! metabolic process relationship: regulates GO:0008152 ! metabolic process [Term] id: GO:0019438 name: aromatic compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai] synonym: "aromatic compound anabolism" EXACT [] synonym: "aromatic compound biosynthesis" EXACT [] synonym: "aromatic compound formation" EXACT [] synonym: "aromatic compound synthesis" EXACT [] synonym: "aromatic hydrocarbon biosynthesis" NARROW [] synonym: "aromatic hydrocarbon biosynthetic process" NARROW [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0019538 name: protein metabolic process namespace: biological_process alt_id: GO:0006411 alt_id: GO:0044268 def: "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir subset: goslim_plant synonym: "multicellular organismal protein metabolic process" NARROW [] synonym: "protein metabolic process and modification" EXACT [] synonym: "protein metabolism" EXACT [] synonym: "protein metabolism and modification" EXACT [] xref: Wikipedia:Protein_metabolism is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:0044238 ! primary metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0019953 name: sexual reproduction namespace: biological_process def: "A reproduction process that creates a new organism by combining the genetic material of two gametes, which may come from two organisms or from a single organism, in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two gametes join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny." [GOC:jl, GOC:kmv, GOC:krc, GOC:tb, ISBN:0387520546, Wikipedia:Sexual_reproduction] comment: Sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. xref: Wikipedia:Sexual_reproduction is_a: GO:0000003 ! reproduction is_a: GO:0044703 ! multi-organism reproductive process [Term] id: GO:0021915 name: neural tube development namespace: biological_process def: "The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0035295 ! tube development is_a: GO:0060429 ! epithelium development relationship: part_of GO:0007399 ! nervous system development relationship: part_of GO:0043009 ! chordate embryonic development [Term] id: GO:0021992 name: cell proliferation involved in neural plate elongation namespace: biological_process def: "The process of expansion of cell numbers in the neural plate due to cell division of progenitor cells preferentially in the rostrocaudal direction, resulting in the elongation of the tissue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15806586] is_a: GO:0061351 ! neural precursor cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: part_of GO:0014022 ! neural plate elongation relationship: part_of GO:0014022 ! neural plate elongation [Term] id: GO:0022007 name: convergent extension involved in neural plate elongation namespace: biological_process def: "The process of directed cell movement in the neural plate resulting in tissue elongation via intercalation of adjacent cells in an epithelial sheet at the midline, leading to narrowing and lengthening of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:13679871, PMID:15806586] is_a: GO:0060027 ! convergent extension involved in gastrulation is_a: GO:0060029 ! convergent extension involved in organogenesis intersection_of: GO:0060026 ! convergent extension intersection_of: part_of GO:0014022 ! neural plate elongation relationship: part_of GO:0014022 ! neural plate elongation [Term] id: GO:0022008 name: neurogenesis namespace: biological_process def: "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] synonym: "nervous system cell generation" EXACT systematic_synonym [] synonym: "neural cell differentiation" RELATED [GOC:BHF, GOC:dph] xref: Wikipedia:Neurogenesis is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0022402 name: cell cycle process namespace: biological_process def: "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] subset: gocheck_do_not_annotate is_a: GO:0009987 ! cellular process intersection_of: GO:0009987 ! cellular process intersection_of: part_of GO:0007049 ! cell cycle relationship: part_of GO:0007049 ! cell cycle [Term] id: GO:0022411 name: cellular component disassembly namespace: biological_process alt_id: GO:0071845 def: "A cellular process that results in the breakdown of a cellular component." [GOC:isa_complete] subset: goslim_pir synonym: "cell structure disassembly" EXACT [] synonym: "cellular component disassembly at cellular level" EXACT [] is_a: GO:0016043 ! cellular component organization [Term] id: GO:0022412 name: cellular process involved in reproduction in multicellular organism namespace: biological_process def: "A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism." [GOC:isa_complete] synonym: "reproductive cellular process in multicellular organism" EXACT [] is_a: GO:0009987 ! cellular process is_a: GO:0022414 ! reproductive process intersection_of: GO:0009987 ! cellular process intersection_of: part_of GO:0032504 ! multicellular organism reproduction relationship: part_of GO:0032504 ! multicellular organism reproduction [Term] id: GO:0022414 name: reproductive process namespace: biological_process alt_id: GO:0044702 def: "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete] synonym: "single organism reproductive process" RELATED [] is_a: GO:0008150 ! biological_process intersection_of: GO:0008150 ! biological_process intersection_of: part_of GO:0000003 ! reproduction relationship: part_of GO:0000003 ! reproduction created_by: jl creation_date: 2012-09-19T15:56:06Z [Term] id: GO:0022603 name: regulation of anatomical structure morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." [GOC:mah] synonym: "regulation of morphogenesis" EXACT [] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009653 ! anatomical structure morphogenesis relationship: regulates GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0022604 name: regulation of cell morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized." [GOC:isa_complete] synonym: "negative regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb] synonym: "regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0000902 ! cell morphogenesis relationship: regulates GO:0000902 ! cell morphogenesis [Term] id: GO:0022607 name: cellular component assembly namespace: biological_process alt_id: GO:0071844 def: "The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete] subset: goslim_chembl subset: goslim_generic subset: goslim_pir synonym: "cell structure assembly" EXACT [] synonym: "cellular component assembly at cellular level" EXACT [] is_a: GO:0016043 ! cellular component organization relationship: part_of GO:0044085 ! cellular component biogenesis [Term] id: GO:0022610 name: biological adhesion namespace: biological_process def: "The attachment of a cell or organism to a substrate, another cell, or other organism. Biological adhesion includes intracellular attachment between membrane regions." [GOC:isa_complete] subset: goslim_pir is_a: GO:0008150 ! biological_process [Term] id: GO:0023019 name: signal transduction involved in regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another." [GOC:mtg_signal] synonym: "regulation of gene expression as a consequence of signal transmission" RELATED [GOC:bf] is_a: GO:0007165 ! signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: part_of GO:0010468 ! regulation of gene expression relationship: part_of GO:0010468 ! regulation of gene expression creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023051 name: regulation of signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal] synonym: "regulation of signaling process" RELATED [GOC:bf] synonym: "regulation of signalling process" RELATED [GOC:mah] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0023052 ! signaling relationship: regulates GO:0023052 ! signaling creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023052 name: signaling namespace: biological_process alt_id: GO:0023046 alt_id: GO:0044700 def: "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling] comment: Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change. subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pombe subset: goslim_yeast synonym: "biological signaling" EXACT [] synonym: "signaling process" EXACT [] synonym: "signalling" EXACT [] synonym: "signalling process" RELATED [GOC:mah] synonym: "single organism signaling" RELATED [] is_a: GO:0008150 ! biological_process created_by: jl creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023056 name: positive regulation of signaling namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process." [GOC:mtg_signal] synonym: "positive regulation of signaling process" RELATED [GOC:bf] synonym: "positive regulation of signalling process" EXACT [GOC:mah] is_a: GO:0023051 ! regulation of signaling is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0023052 ! signaling relationship: positively_regulates GO:0023052 ! signaling creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023057 name: negative regulation of signaling namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal] synonym: "negative regulation of signaling process" RELATED [GOC:bf] synonym: "negative regulation of signalling process" RELATED [GOC:mah] is_a: GO:0023051 ! regulation of signaling is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0023052 ! signaling relationship: negatively_regulates GO:0023052 ! signaling creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0030001 name: metal ion transport namespace: biological_process alt_id: GO:0070838 def: "The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "divalent metal ion transport" NARROW [] synonym: "heavy metal ion transport" NARROW [] is_a: GO:0006812 ! cation transport [Term] id: GO:0030010 name: establishment of cell polarity namespace: biological_process alt_id: GO:0000283 alt_id: GO:0030468 def: "The specification and formation of anisotropic intracellular organization or cell growth patterns." [GOC:mah] synonym: "bud site selection/establishment of cell polarity" NARROW [] synonym: "cell polarization" EXACT [] is_a: GO:0007163 ! establishment or maintenance of cell polarity [Term] id: GO:0030029 name: actin filament-based process namespace: biological_process def: "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah] synonym: "microfilament-based process" RELATED [] is_a: GO:0009987 ! cellular process [Term] id: GO:0030030 name: cell projection organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/] synonym: "cell projection organisation" EXACT [] synonym: "cell projection organization and biogenesis" RELATED [GOC:mah] synonym: "cell surface structure organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016043 ! cellular component organization [Term] id: GO:0030031 name: cell projection assembly namespace: biological_process def: "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/] synonym: "cell projection biogenesis" RELATED [GOC:mah] synonym: "formation of a cell surface projection" EXACT [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0030030 ! cell projection organization [Term] id: GO:0030036 name: actin cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_drosophila subset: goslim_pombe synonym: "actin cytoskeleton organisation" EXACT [] synonym: "actin cytoskeleton organization and biogenesis" RELATED [GOC:mah] synonym: "actin modulating activity" RELATED [] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0030029 ! actin filament-based process [Term] id: GO:0030048 name: actin filament-based movement namespace: biological_process def: "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah] is_a: GO:0006928 ! movement of cell or subcellular component is_a: GO:0030029 ! actin filament-based process [Term] id: GO:0030111 name: regulation of Wnt signaling pathway namespace: biological_process alt_id: GO:0008590 def: "Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb] synonym: "regulation of frizzled signaling pathway" EXACT [] synonym: "regulation of frizzled signalling pathway" EXACT [] synonym: "regulation of Wnt receptor signaling pathway" EXACT [] synonym: "regulation of Wnt receptor signalling pathway" EXACT [] synonym: "regulation of Wnt-activated signaling pathway" EXACT [GOC:signaling] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016055 ! Wnt signaling pathway relationship: regulates GO:0016055 ! Wnt signaling pathway [Term] id: GO:0030141 name: secretory granule namespace: cellular_component def: "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732] comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'transport vesicle ; GO:0030133'. synonym: "secretory vesicle" BROAD [] is_a: GO:0099503 ! secretory vesicle relationship: part_of GO:0012505 ! endomembrane system property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0030154 name: cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_mouse subset: goslim_plant xref: Wikipedia:Cellular_differentiation is_a: GO:0048869 ! cellular developmental process [Term] id: GO:0030155 name: regulation of cell adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix." [GOC:mah] synonym: "cell adhesion receptor regulator activity" RELATED [] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007155 ! cell adhesion relationship: regulates GO:0007155 ! cell adhesion [Term] id: GO:0030162 name: regulation of proteolysis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] synonym: "regulation of peptidolysis" EXACT [] is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006508 ! proteolysis relationship: regulates GO:0006508 ! proteolysis [Term] id: GO:0030177 name: positive regulation of Wnt signaling pathway namespace: biological_process alt_id: GO:0045811 def: "Any process that activates or increases the frequency, rate or extent of Wnt signal transduction." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of frizzled signaling pathway" NARROW [] synonym: "activation of Wnt receptor signaling pathway" NARROW [] synonym: "positive regulation of frizzled signaling pathway" EXACT [] synonym: "positive regulation of frizzled signalling pathway" EXACT [] synonym: "positive regulation of Wnt receptor signaling pathway" EXACT [] synonym: "positive regulation of Wnt receptor signalling pathway" EXACT [] synonym: "positive regulation of Wnt-activated signaling pathway" EXACT [GOC:signaling] synonym: "stimulation of frizzled signaling pathway" NARROW [] synonym: "stimulation of Wnt receptor signaling pathway" NARROW [] synonym: "up regulation of frizzled signaling pathway" EXACT [] synonym: "up regulation of Wnt receptor signaling pathway" EXACT [] synonym: "up-regulation of frizzled signaling pathway" EXACT [] synonym: "up-regulation of Wnt receptor signaling pathway" EXACT [] synonym: "upregulation of frizzled signaling pathway" EXACT [] synonym: "upregulation of Wnt receptor signaling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0030111 ! regulation of Wnt signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0016055 ! Wnt signaling pathway relationship: positively_regulates GO:0016055 ! Wnt signaling pathway [Term] id: GO:0030178 name: negative regulation of Wnt signaling pathway namespace: biological_process alt_id: GO:0045810 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of frizzled signaling pathway" EXACT [] synonym: "down regulation of Wnt receptor signaling pathway" EXACT [] synonym: "down-regulation of frizzled signaling pathway" EXACT [] synonym: "down-regulation of Wnt receptor signaling pathway" EXACT [] synonym: "downregulation of frizzled signaling pathway" EXACT [] synonym: "downregulation of Wnt receptor signaling pathway" EXACT [] synonym: "inhibition of frizzled signaling pathway" NARROW [] synonym: "inhibition of Wnt receptor signaling pathway" NARROW [] synonym: "negative regulation of frizzled signaling pathway" EXACT [] synonym: "negative regulation of frizzled signalling pathway" EXACT [] synonym: "negative regulation of Wnt receptor signaling pathway" EXACT [] synonym: "negative regulation of Wnt receptor signalling pathway" EXACT [] synonym: "negative regulation of Wnt-activated signaling pathway" EXACT [GOC:signaling] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0030111 ! regulation of Wnt signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0016055 ! Wnt signaling pathway relationship: negatively_regulates GO:0016055 ! Wnt signaling pathway [Term] id: GO:0030182 name: neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0048699 ! generation of neurons [Term] id: GO:0030239 name: myofibril assembly namespace: biological_process def: "Formation of myofibrils, the repeating units of striated muscle." [GOC:mah] is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0031032 ! actomyosin structure organization is_a: GO:0070925 ! organelle assembly is_a: GO:0097435 ! supramolecular fiber organization relationship: part_of GO:0055002 ! striated muscle cell development [Term] id: GO:0030307 name: positive regulation of cell growth namespace: biological_process def: "Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators] synonym: "activation of cell growth" NARROW [] synonym: "stimulation of cell growth" NARROW [] synonym: "up regulation of cell growth" EXACT [] synonym: "up-regulation of cell growth" EXACT [] synonym: "upregulation of cell growth" EXACT [] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0045927 ! positive regulation of growth is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0016049 ! cell growth relationship: positively_regulates GO:0016049 ! cell growth [Term] id: GO:0030308 name: negative regulation of cell growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators] synonym: "down regulation of cell growth" EXACT [] synonym: "down-regulation of cell growth" EXACT [] synonym: "downregulation of cell growth" EXACT [] synonym: "inhibition of cell growth" NARROW [] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0045926 ! negative regulation of growth is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0016049 ! cell growth relationship: negatively_regulates GO:0016049 ! cell growth [Term] id: GO:0030334 name: regulation of cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators] is_a: GO:2000145 ! regulation of cell motility intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016477 ! cell migration relationship: regulates GO:0016477 ! cell migration [Term] id: GO:0030335 name: positive regulation of cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators] synonym: "activation of cell migration" NARROW [] synonym: "stimulation of cell migration" NARROW [] synonym: "up regulation of cell migration" EXACT [] synonym: "up-regulation of cell migration" EXACT [] synonym: "upregulation of cell migration" EXACT [] is_a: GO:0030334 ! regulation of cell migration is_a: GO:2000147 ! positive regulation of cell motility intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0016477 ! cell migration relationship: positively_regulates GO:0016477 ! cell migration [Term] id: GO:0030336 name: negative regulation of cell migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators] synonym: "down regulation of cell migration" EXACT [] synonym: "down-regulation of cell migration" EXACT [] synonym: "downregulation of cell migration" EXACT [] synonym: "inhibition of cell migration" NARROW [] is_a: GO:0030334 ! regulation of cell migration is_a: GO:2000146 ! negative regulation of cell motility intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0016477 ! cell migration relationship: negatively_regulates GO:0016477 ! cell migration [Term] id: GO:0030509 name: BMP signaling pathway namespace: biological_process alt_id: GO:0008101 def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0878932437, PMID:17428827] synonym: "BMP receptor signaling pathway" RELATED [] synonym: "BMP signalling pathway" EXACT [] synonym: "bone morphogenetic protein signaling pathway" EXACT [] synonym: "bone morphogenetic protein signalling pathway" EXACT [] synonym: "decapentaplegic receptor signaling pathway" NARROW [GOC:bf, GOC:sart, GOC:signaling] synonym: "decapentaplegic receptor signalling pathway" NARROW [] synonym: "decapentaplegic signaling pathway" NARROW [] synonym: "dpp receptor signaling pathway" NARROW [] synonym: "dpp receptor signalling pathway" NARROW [] synonym: "dpp signaling pathway" NARROW [GOC:bf] is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway relationship: part_of GO:0071773 ! cellular response to BMP stimulus [Term] id: GO:0030510 name: regulation of BMP signaling pathway namespace: biological_process alt_id: GO:0090097 def: "Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway." [GOC:mah] synonym: "regulation of BMP receptor signaling pathway" RELATED [] synonym: "regulation of BMP signalling pathway" EXACT [] synonym: "regulation of bone morphogenetic protein signaling pathway" EXACT [] synonym: "regulation of bone morphogenetic protein signalling pathway" EXACT [] synonym: "regulation of decapentaplegic receptor signaling pathway" NARROW [GOC:bf] synonym: "regulation of decapentaplegic receptor signalling pathway" NARROW [GOC:mah] synonym: "regulation of decapentaplegic signaling pathway" NARROW [] is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0030509 ! BMP signaling pathway relationship: regulates GO:0030509 ! BMP signaling pathway created_by: tb creation_date: 2009-11-13T10:49:14Z [Term] id: GO:0030513 name: positive regulation of BMP signaling pathway namespace: biological_process alt_id: GO:0090098 def: "Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity." [GOC:go_curators] synonym: "activation of BMP signaling pathway" NARROW [] synonym: "positive regulation of BMP receptor signaling pathway" RELATED [] synonym: "positive regulation of BMP signalling pathway" EXACT [] synonym: "positive regulation of bone morphogenetic protein signaling pathway" EXACT [] synonym: "positive regulation of bone morphogenetic protein signalling pathway" EXACT [] synonym: "positive regulation of decapentaplegic receptor signaling pathway" NARROW [GOC:bf] synonym: "positive regulation of decapentaplegic receptor signalling pathway" NARROW [GOC:mah] synonym: "positive regulation of decapentaplegic signaling pathway" NARROW [] synonym: "stimulation of BMP signaling pathway" NARROW [] synonym: "up regulation of BMP signaling pathway" EXACT [] synonym: "up-regulation of BMP signaling pathway" EXACT [] synonym: "upregulation of BMP signaling pathway" EXACT [] is_a: GO:0030510 ! regulation of BMP signaling pathway is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0030509 ! BMP signaling pathway relationship: positively_regulates GO:0030509 ! BMP signaling pathway created_by: tb creation_date: 2009-11-13T10:50:41Z [Term] id: GO:0030514 name: negative regulation of BMP signaling pathway namespace: biological_process alt_id: GO:0090099 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway." [GOC:go_curators] synonym: "down regulation of BMP signaling pathway" EXACT [] synonym: "down-regulation of BMP signaling pathway" EXACT [] synonym: "downregulation of BMP signaling pathway" EXACT [] synonym: "inhibition of BMP signaling pathway" NARROW [] synonym: "negative regulation of BMP receptor signaling pathway" RELATED [] synonym: "negative regulation of BMP signalling pathway" EXACT [] synonym: "negative regulation of bone morphogenetic protein signaling pathway" EXACT [] synonym: "negative regulation of bone morphogenetic protein signalling pathway" EXACT [] synonym: "negative regulation of decapentaplegic receptor signaling pathway" NARROW [GOC:bf] synonym: "negative regulation of decapentaplegic receptor signalling pathway" NARROW [GOC:mah] synonym: "negative regulation of decapentaplegic signaling pathway" NARROW [] is_a: GO:0030510 ! regulation of BMP signaling pathway is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0030509 ! BMP signaling pathway relationship: negatively_regulates GO:0030509 ! BMP signaling pathway created_by: tb creation_date: 2009-11-13T10:51:30Z [Term] id: GO:0030516 name: regulation of axon extension namespace: biological_process def: "Any process that modulates the rate, direction or extent of axon extension." [GOC:go_curators] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0061387 ! regulation of extent of cell growth intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0048675 ! axon extension relationship: regulates GO:0048675 ! axon extension [Term] id: GO:0030517 name: negative regulation of axon extension namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth." [GOC:mah] synonym: "down regulation of axon extension" EXACT [] synonym: "down-regulation of axon extension" EXACT [] synonym: "downregulation of axon extension" EXACT [] synonym: "inhibition of axon extension" NARROW [] is_a: GO:0030308 ! negative regulation of cell growth is_a: GO:0030516 ! regulation of axon extension is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0050771 ! negative regulation of axonogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0048675 ! axon extension relationship: negatively_regulates GO:0048675 ! axon extension [Term] id: GO:0030705 name: cytoskeleton-dependent intracellular transport namespace: biological_process def: "The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic is_a: GO:0046907 ! intracellular transport [Term] id: GO:0030855 name: epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0060429 ! epithelium development [Term] id: GO:0030856 name: regulation of epithelial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell differentiation." [GOC:mah] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0030855 ! epithelial cell differentiation relationship: regulates GO:0030855 ! epithelial cell differentiation [Term] id: GO:0030857 name: negative regulation of epithelial cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation." [GOC:mah] synonym: "down regulation of epithelial cell differentiation" EXACT [] synonym: "down-regulation of epithelial cell differentiation" EXACT [] synonym: "downregulation of epithelial cell differentiation" EXACT [] synonym: "inhibition of epithelial cell differentiation" NARROW [] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0045596 ! negative regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0030855 ! epithelial cell differentiation relationship: negatively_regulates GO:0030855 ! epithelial cell differentiation [Term] id: GO:0030858 name: positive regulation of epithelial cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation." [GOC:mah] synonym: "activation of epithelial cell differentiation" NARROW [] synonym: "stimulation of epithelial cell differentiation" NARROW [] synonym: "up regulation of epithelial cell differentiation" EXACT [] synonym: "up-regulation of epithelial cell differentiation" EXACT [] synonym: "upregulation of epithelial cell differentiation" EXACT [] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0045597 ! positive regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0030855 ! epithelial cell differentiation relationship: positively_regulates GO:0030855 ! epithelial cell differentiation [Term] id: GO:0030903 name: notochord development namespace: biological_process def: "The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column." [GOC:dgh] is_a: GO:0048568 ! embryonic organ development [Term] id: GO:0030990 name: intraciliary transport particle namespace: cellular_component def: "A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules." [GOC:cilia, GOC:kmv, PMID:14570576, PMID:22118932, PMID:23945166] comment: Note that we deem cilia and microtubule-based flagella to be equivalent. subset: goslim_pir synonym: "IFT complex" RELATED [] synonym: "intraflagellar transport complex" EXACT [] synonym: "intraflagellar transport particle" EXACT [] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0031016 name: pancreas development namespace: biological_process def: "The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes." [GOC:cvs] xref: Wikipedia:Pancreas is_a: GO:0048513 ! animal organ development [Term] id: GO:0031018 name: endocrine pancreas development namespace: biological_process def: "The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin." [GOC:cvs] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0031016 ! pancreas development relationship: part_of GO:0035270 ! endocrine system development [Term] id: GO:0031023 name: microtubule organizing center organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "microtubule organising center organisation" EXACT [] synonym: "microtubule organizing center organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007017 ! microtubule-based process is_a: GO:0016043 ! cellular component organization relationship: part_of GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0031032 name: actomyosin structure organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah] comment: Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins. synonym: "actomyosin organization" EXACT [] synonym: "actomyosin structure organisation" EXACT [] synonym: "actomyosin structure organization and biogenesis" RELATED [GOC:mah] is_a: GO:0030036 ! actin cytoskeleton organization [Term] id: GO:0031045 name: dense core granule namespace: cellular_component def: "Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted." [NIF_Subcellular:sao772007592, PMID:14690495] synonym: "dense core vesicle" EXACT syngo_official_label [GOC:kmv] xref: NIF_Subcellular:sao772007592 is_a: GO:0030141 ! secretory granule [Term] id: GO:0031056 name: regulation of histone modification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:1902275 ! regulation of chromatin organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016570 ! histone modification relationship: regulates GO:0016570 ! histone modification [Term] id: GO:0031057 name: negative regulation of histone modification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah] synonym: "down regulation of histone modification" EXACT [] synonym: "down-regulation of histone modification" EXACT [] synonym: "downregulation of histone modification" EXACT [] synonym: "inhibition of histone modification" NARROW [] is_a: GO:0031056 ! regulation of histone modification is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:1905268 ! negative regulation of chromatin organization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0016570 ! histone modification relationship: negatively_regulates GO:0016570 ! histone modification [Term] id: GO:0031058 name: positive regulation of histone modification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah] synonym: "activation of histone modification" NARROW [] synonym: "stimulation of histone modification" NARROW [] synonym: "up regulation of histone modification" EXACT [] synonym: "up-regulation of histone modification" EXACT [] synonym: "upregulation of histone modification" EXACT [] is_a: GO:0031056 ! regulation of histone modification is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:1905269 ! positive regulation of chromatin organization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0016570 ! histone modification relationship: positively_regulates GO:0016570 ! histone modification [Term] id: GO:0031060 name: regulation of histone methylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah] is_a: GO:0031056 ! regulation of histone modification intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016571 ! histone methylation relationship: regulates GO:0016571 ! histone methylation [Term] id: GO:0031061 name: negative regulation of histone methylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah] synonym: "down regulation of histone methylation" EXACT [] synonym: "down-regulation of histone methylation" EXACT [] synonym: "downregulation of histone methylation" EXACT [] synonym: "inhibition of histone methylation" NARROW [] is_a: GO:0031057 ! negative regulation of histone modification is_a: GO:0031060 ! regulation of histone methylation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0016571 ! histone methylation relationship: negatively_regulates GO:0016571 ! histone methylation [Term] id: GO:0031062 name: positive regulation of histone methylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah] synonym: "activation of histone methylation" NARROW [] synonym: "stimulation of histone methylation" NARROW [] synonym: "up regulation of histone methylation" EXACT [] synonym: "up-regulation of histone methylation" EXACT [] synonym: "upregulation of histone methylation" EXACT [] is_a: GO:0031058 ! positive regulation of histone modification is_a: GO:0031060 ! regulation of histone methylation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0016571 ! histone methylation relationship: positively_regulates GO:0016571 ! histone methylation [Term] id: GO:0031098 name: stress-activated protein kinase signaling cascade namespace: biological_process def: "A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals." [GOC:mah] synonym: "JNK signaling pathway" NARROW [] synonym: "JNK signalling pathway" NARROW [] synonym: "SAPK signaling pathway" EXACT [] synonym: "SAPK signalling pathway" EXACT [] synonym: "stress-activated protein kinase signaling pathway" EXACT [] synonym: "stress-activated protein kinase signalling pathway" EXACT [] is_a: GO:0033554 ! cellular response to stress is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0031099 name: regeneration namespace: biological_process def: "The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass)." [GOC:mah, GOC:pr] xref: Wikipedia:Regeneration_(biology) is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0031102 name: neuron projection regeneration namespace: biological_process def: "The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage." [GOC:dgh, GOC:dph, GOC:tb] synonym: "neurite regeneration" NARROW [GOC:mah] is_a: GO:0031099 ! regeneration is_a: GO:0031175 ! neuron projection development is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0031103 name: axon regeneration namespace: biological_process def: "The regrowth of axons following their loss or damage." [GOC:dgh, GOC:dph, GOC:tb] is_a: GO:0031102 ! neuron projection regeneration is_a: GO:0048678 ! response to axon injury is_a: GO:0061564 ! axon development [Term] id: GO:0031175 name: neuron projection development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah] synonym: "neurite biosynthesis" NARROW [] synonym: "neurite development" NARROW [GOC:dph] synonym: "neurite formation" NARROW [] synonym: "neurite growth" NARROW [] synonym: "neurite outgrowth" NARROW [] is_a: GO:0120036 ! plasma membrane bounded cell projection organization intersection_of: GO:0120036 ! plasma membrane bounded cell projection organization intersection_of: part_of GO:0048666 ! neuron development relationship: part_of GO:0048666 ! neuron development [Term] id: GO:0031323 name: regulation of cellular metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah] synonym: "regulation of cellular metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0044237 ! cellular metabolic process relationship: regulates GO:0044237 ! cellular metabolic process [Term] id: GO:0031324 name: negative regulation of cellular metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah] synonym: "down regulation of cellular metabolic process" EXACT [] synonym: "down-regulation of cellular metabolic process" EXACT [] synonym: "downregulation of cellular metabolic process" EXACT [] synonym: "inhibition of cellular metabolic process" NARROW [] synonym: "negative regulation of cellular metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0044237 ! cellular metabolic process relationship: negatively_regulates GO:0044237 ! cellular metabolic process [Term] id: GO:0031325 name: positive regulation of cellular metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah] synonym: "activation of cellular metabolic process" NARROW [] synonym: "positive regulation of cellular metabolism" EXACT [] synonym: "stimulation of cellular metabolic process" NARROW [] synonym: "up regulation of cellular metabolic process" EXACT [] synonym: "up-regulation of cellular metabolic process" EXACT [] synonym: "upregulation of cellular metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0044237 ! cellular metabolic process relationship: positively_regulates GO:0044237 ! cellular metabolic process [Term] id: GO:0031326 name: regulation of cellular biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah] synonym: "regulation of cellular anabolism" EXACT [] synonym: "regulation of cellular biosynthesis" EXACT [] synonym: "regulation of cellular formation" EXACT [] synonym: "regulation of cellular synthesis" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0044249 ! cellular biosynthetic process relationship: regulates GO:0044249 ! cellular biosynthetic process [Term] id: GO:0031327 name: negative regulation of cellular biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah] synonym: "down regulation of cellular biosynthetic process" EXACT [] synonym: "down-regulation of cellular biosynthetic process" EXACT [] synonym: "downregulation of cellular biosynthetic process" EXACT [] synonym: "inhibition of cellular biosynthetic process" NARROW [] synonym: "negative regulation of cellular anabolism" EXACT [] synonym: "negative regulation of cellular biosynthesis" EXACT [] synonym: "negative regulation of cellular formation" EXACT [] synonym: "negative regulation of cellular synthesis" EXACT [] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0044249 ! cellular biosynthetic process relationship: negatively_regulates GO:0044249 ! cellular biosynthetic process [Term] id: GO:0031328 name: positive regulation of cellular biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah] synonym: "activation of cellular biosynthetic process" NARROW [] synonym: "positive regulation of cellular anabolism" EXACT [] synonym: "positive regulation of cellular biosynthesis" EXACT [] synonym: "positive regulation of cellular formation" EXACT [] synonym: "positive regulation of cellular synthesis" EXACT [] synonym: "stimulation of cellular biosynthetic process" NARROW [] synonym: "up regulation of cellular biosynthetic process" EXACT [] synonym: "up-regulation of cellular biosynthetic process" EXACT [] synonym: "upregulation of cellular biosynthetic process" EXACT [] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0044249 ! cellular biosynthetic process relationship: positively_regulates GO:0044249 ! cellular biosynthetic process [Term] id: GO:0031344 name: regulation of cell projection organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] synonym: "regulation of cell projection organisation" EXACT [] synonym: "regulation of cell projection organization and biogenesis" RELATED [GOC:mah] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0030030 ! cell projection organization relationship: regulates GO:0030030 ! cell projection organization [Term] id: GO:0031345 name: negative regulation of cell projection organization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] synonym: "down regulation of cell projection organization" EXACT [GOC:mah] synonym: "down-regulation of cell projection organization" EXACT [] synonym: "downregulation of cell projection organization" EXACT [] synonym: "inhibition of cell projection organization" NARROW [] synonym: "negative regulation of cell projection organisation" EXACT [] synonym: "negative regulation of cell projection organization and biogenesis" RELATED [GOC:mah] is_a: GO:0031344 ! regulation of cell projection organization is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0030030 ! cell projection organization relationship: negatively_regulates GO:0030030 ! cell projection organization [Term] id: GO:0031346 name: positive regulation of cell projection organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] synonym: "activation of cell projection organization" NARROW [] synonym: "positive regulation of cell projection organisation" EXACT [] synonym: "positive regulation of cell projection organization and biogenesis" RELATED [GOC:mah] synonym: "stimulation of cell projection organization" NARROW [] synonym: "up regulation of cell projection organization" EXACT [] synonym: "up-regulation of cell projection organization" EXACT [] synonym: "upregulation of cell projection organization" EXACT [] is_a: GO:0031344 ! regulation of cell projection organization is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0030030 ! cell projection organization relationship: positively_regulates GO:0030030 ! cell projection organization [Term] id: GO:0031399 name: regulation of protein modification process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] subset: goslim_yeast is_a: GO:0032268 ! regulation of cellular protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006464 ! cellular protein modification process relationship: regulates GO:0006464 ! cellular protein modification process [Term] id: GO:0031400 name: negative regulation of protein modification process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] synonym: "down regulation of protein modification" EXACT [] synonym: "down-regulation of protein modification" EXACT [] synonym: "downregulation of protein modification" EXACT [] synonym: "inhibition of protein modification" NARROW [] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0032269 ! negative regulation of cellular protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006464 ! cellular protein modification process relationship: negatively_regulates GO:0006464 ! cellular protein modification process [Term] id: GO:0031401 name: positive regulation of protein modification process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] synonym: "activation of protein modification" NARROW [] synonym: "stimulation of protein modification" NARROW [] synonym: "up regulation of protein modification" EXACT [] synonym: "up-regulation of protein modification" EXACT [] synonym: "upregulation of protein modification" EXACT [] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0032270 ! positive regulation of cellular protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006464 ! cellular protein modification process relationship: positively_regulates GO:0006464 ! cellular protein modification process [Term] id: GO:0031410 name: cytoplasmic vesicle namespace: cellular_component alt_id: GO:0016023 def: "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_yeast synonym: "cytoplasmic membrane bounded vesicle" RELATED [] synonym: "cytoplasmic membrane-enclosed vesicle" RELATED [] synonym: "cytoplasmic, membrane-bounded vesicle" RELATED [] xref: NIF_Subcellular:sao180601769 is_a: GO:0097708 ! intracellular vesicle intersection_of: GO:0031982 ! vesicle intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0031503 name: protein-containing complex localization namespace: biological_process def: "A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location." [GOC:mah] synonym: "establishment and maintenance of protein complex localization" EXACT [] synonym: "protein complex localisation" EXACT [GOC:mah] synonym: "protein complex localization" RELATED [] is_a: GO:0008104 ! protein localization [Term] id: GO:0031941 name: filamentous actin namespace: cellular_component def: "A two-stranded helical polymer of the protein actin." [GOC:mah] comment: Note that this term refers only to the actin portion of a microfilament, and does not encompass associated proteins. See also the cellular component term 'actin filament ; GO:0005884'. synonym: "F-actin" EXACT [] xref: Wikipedia:Actin is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005884 ! actin filament [Term] id: GO:0031982 name: vesicle namespace: cellular_component alt_id: GO:0031988 def: "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] subset: goslim_pir synonym: "membrane-bounded vesicle" RELATED [] synonym: "membrane-enclosed vesicle" RELATED [] xref: NIF_Subcellular:sao221389602 xref: Wikipedia:Vesicle_(biology) is_a: GO:0043227 ! membrane-bounded organelle [Term] id: GO:0031987 name: locomotion involved in locomotory behavior namespace: biological_process def: "Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah] synonym: "locomotion during locomotory behaviour" EXACT [] is_a: GO:0040011 ! locomotion intersection_of: GO:0040011 ! locomotion intersection_of: part_of GO:0007626 ! locomotory behavior relationship: part_of GO:0007626 ! locomotory behavior [Term] id: GO:0032053 name: ciliary basal body organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ciliary basal body, a short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum)." [GOC:cilia, GOC:dph, GOC:jl, GOC:krc, GOC:mah, PMID:9889124] synonym: "microtubule basal body organisation" BROAD [GOC:mah] synonym: "microtubule basal body organization" BROAD [] synonym: "microtubule basal body organization and biogenesis" RELATED [GOC:mah] is_a: GO:0031023 ! microtubule organizing center organization is_a: GO:0044782 ! cilium organization [Term] id: GO:0032101 name: regulation of response to external stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009605 ! response to external stimulus relationship: regulates GO:0009605 ! response to external stimulus [Term] id: GO:0032102 name: negative regulation of response to external stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "down regulation of response to external stimulus" EXACT [] synonym: "down-regulation of response to external stimulus" EXACT [] synonym: "downregulation of response to external stimulus" EXACT [] synonym: "inhibition of response to external stimulus" NARROW [] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009605 ! response to external stimulus relationship: negatively_regulates GO:0009605 ! response to external stimulus [Term] id: GO:0032103 name: positive regulation of response to external stimulus namespace: biological_process def: "Any process that activates, maintains or increases the rate of a response to an external stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "activation of response to external stimulus" NARROW [] synonym: "stimulation of response to external stimulus" NARROW [] synonym: "up regulation of response to external stimulus" EXACT [] synonym: "up-regulation of response to external stimulus" EXACT [] synonym: "upregulation of response to external stimulus" EXACT [] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009605 ! response to external stimulus relationship: positively_regulates GO:0009605 ! response to external stimulus [Term] id: GO:0032259 name: methylation namespace: biological_process def: "The process in which a methyl group is covalently attached to a molecule." [GOC:mah] subset: goslim_chembl xref: Wikipedia:Methylation is_a: GO:0008152 ! metabolic process [Term] id: GO:0032268 name: regulation of cellular protein metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah] synonym: "regulation of cellular protein metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0044267 ! cellular protein metabolic process relationship: regulates GO:0044267 ! cellular protein metabolic process [Term] id: GO:0032269 name: negative regulation of cellular protein metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah] synonym: "down regulation of cellular protein metabolic process" EXACT [] synonym: "down-regulation of cellular protein metabolic process" EXACT [] synonym: "downregulation of cellular protein metabolic process" EXACT [] synonym: "inhibition of cellular protein metabolic process" NARROW [] synonym: "negative regulation of cellular protein metabolism" EXACT [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:0051248 ! negative regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0044267 ! cellular protein metabolic process relationship: negatively_regulates GO:0044267 ! cellular protein metabolic process [Term] id: GO:0032270 name: positive regulation of cellular protein metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah] synonym: "activation of cellular protein metabolic process" NARROW [] synonym: "positive regulation of cellular protein metabolism" EXACT [] synonym: "stimulation of cellular protein metabolic process" NARROW [] synonym: "up regulation of cellular protein metabolic process" EXACT [] synonym: "up-regulation of cellular protein metabolic process" EXACT [] synonym: "upregulation of cellular protein metabolic process" EXACT [] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:0051247 ! positive regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0044267 ! cellular protein metabolic process relationship: positively_regulates GO:0044267 ! cellular protein metabolic process [Term] id: GO:0032350 name: regulation of hormone metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah] synonym: "regulation of hormone metabolism" EXACT [] is_a: GO:0010817 ! regulation of hormone levels is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0042445 ! hormone metabolic process relationship: regulates GO:0042445 ! hormone metabolic process [Term] id: GO:0032351 name: negative regulation of hormone metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah] synonym: "down regulation of hormone metabolic process" EXACT [] synonym: "down-regulation of hormone metabolic process" EXACT [] synonym: "downregulation of hormone metabolic process" EXACT [] synonym: "inhibition of hormone metabolic process" NARROW [] synonym: "negative regulation of hormone metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0042445 ! hormone metabolic process relationship: negatively_regulates GO:0042445 ! hormone metabolic process [Term] id: GO:0032352 name: positive regulation of hormone metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah] synonym: "activation of hormone metabolic process" NARROW [] synonym: "positive regulation of hormone metabolism" EXACT [] synonym: "stimulation of hormone metabolic process" NARROW [] synonym: "up regulation of hormone metabolic process" EXACT [] synonym: "up-regulation of hormone metabolic process" EXACT [] synonym: "upregulation of hormone metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0042445 ! hormone metabolic process relationship: positively_regulates GO:0042445 ! hormone metabolic process [Term] id: GO:0032386 name: regulation of intracellular transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] is_a: GO:0051049 ! regulation of transport is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0046907 ! intracellular transport relationship: regulates GO:0046907 ! intracellular transport [Term] id: GO:0032387 name: negative regulation of intracellular transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] synonym: "down regulation of intracellular transport" EXACT [] synonym: "down-regulation of intracellular transport" EXACT [] synonym: "downregulation of intracellular transport" EXACT [] synonym: "inhibition of intracellular transport" NARROW [] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0046907 ! intracellular transport relationship: negatively_regulates GO:0046907 ! intracellular transport [Term] id: GO:0032388 name: positive regulation of intracellular transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] synonym: "activation of intracellular transport" NARROW [] synonym: "stimulation of intracellular transport" NARROW [] synonym: "up regulation of intracellular transport" EXACT [] synonym: "up-regulation of intracellular transport" EXACT [] synonym: "upregulation of intracellular transport" EXACT [] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0046907 ! intracellular transport relationship: positively_regulates GO:0046907 ! intracellular transport [Term] id: GO:0032465 name: regulation of cytokinesis namespace: biological_process alt_id: GO:0071775 def: "Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:mah] synonym: "regulation of cell cycle cytokinesis" EXACT [] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0000910 ! cytokinesis relationship: regulates GO:0000910 ! cytokinesis [Term] id: GO:0032466 name: negative regulation of cytokinesis namespace: biological_process alt_id: GO:0071776 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells." [GOC:mah] synonym: "down regulation of cytokinesis" EXACT [] synonym: "down-regulation of cytokinesis" EXACT [] synonym: "downregulation of cytokinesis" EXACT [] synonym: "inhibition of cytokinesis" NARROW [] synonym: "negative regulation of cell cycle cytokinesis" RELATED [] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0032465 ! regulation of cytokinesis is_a: GO:0051782 ! negative regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0000910 ! cytokinesis relationship: negatively_regulates GO:0000910 ! cytokinesis [Term] id: GO:0032467 name: positive regulation of cytokinesis namespace: biological_process alt_id: GO:0071777 def: "Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells." [GOC:mah] synonym: "activation of cytokinesis" NARROW [] synonym: "positive regulation of cell cycle cytokinesis" RELATED [] synonym: "stimulation of cytokinesis" NARROW [] synonym: "up regulation of cytokinesis" EXACT [] synonym: "up-regulation of cytokinesis" EXACT [] synonym: "upregulation of cytokinesis" EXACT [] is_a: GO:0032465 ! regulation of cytokinesis is_a: GO:0051781 ! positive regulation of cell division is_a: GO:0090068 ! positive regulation of cell cycle process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0000910 ! cytokinesis relationship: positively_regulates GO:0000910 ! cytokinesis [Term] id: GO:0032501 name: multicellular organismal process namespace: biological_process alt_id: GO:0044707 alt_id: GO:0050874 def: "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb] subset: goslim_pir synonym: "organismal physiological process" EXACT [] synonym: "single-multicellular organism process" RELATED [] is_a: GO:0008150 ! biological_process property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 created_by: jl creation_date: 2012-09-19T16:07:47Z [Term] id: GO:0032502 name: developmental process namespace: biological_process alt_id: GO:0044767 def: "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete] subset: goslim_agr subset: goslim_aspergillus subset: goslim_flybase_ribbon subset: goslim_pir synonym: "development" NARROW [] synonym: "single-organism developmental process" RELATED [] is_a: GO:0008150 ! biological_process created_by: jl creation_date: 2012-12-19T12:21:31Z [Term] id: GO:0032504 name: multicellular organism reproduction namespace: biological_process def: "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] is_a: GO:0000003 ! reproduction is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0032535 name: regulation of cellular component size namespace: biological_process def: "A process that modulates the size of a cellular component." [GOC:mah] is_a: GO:0016043 ! cellular component organization is_a: GO:0090066 ! regulation of anatomical structure size [Term] id: GO:0032594 name: protein transport within lipid bilayer namespace: biological_process def: "The directed movement of a protein from one location to another within a lipid bilayer." [GOC:mah] synonym: "protein translocation within membrane" EXACT [] synonym: "receptor translocation within membrane" NARROW [] synonym: "receptor transport within lipid bilayer" NARROW [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0051668 ! localization within membrane is_a: GO:0061024 ! membrane organization intersection_of: GO:0015031 ! protein transport intersection_of: occurs_in GO:0016020 ! membrane [Term] id: GO:0032774 name: RNA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH] comment: Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study. synonym: "RNA anabolism" EXACT [] synonym: "RNA biosynthesis" EXACT [] synonym: "RNA formation" EXACT [] synonym: "RNA synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0016070 ! RNA metabolic process is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process [Term] id: GO:0032838 name: plasma membrane bounded cell projection cytoplasm namespace: cellular_component def: "All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection." [GOC:krc, GOC:mah] is_a: GO:0099568 ! cytoplasmic region intersection_of: GO:0005737 ! cytoplasm intersection_of: part_of GO:0120025 ! plasma membrane bounded cell projection relationship: part_of GO:0120025 ! plasma membrane bounded cell projection [Term] id: GO:0032868 name: response to insulin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] synonym: "response to insulin stimulus" EXACT [GOC:dos] is_a: GO:0043434 ! response to peptide hormone [Term] id: GO:0032869 name: cellular response to insulin stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] is_a: GO:0032868 ! response to insulin is_a: GO:0071375 ! cellular response to peptide hormone stimulus [Term] id: GO:0032870 name: cellular response to hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah] is_a: GO:0009725 ! response to hormone is_a: GO:0071310 ! cellular response to organic substance is_a: GO:0071495 ! cellular response to endogenous stimulus [Term] id: GO:0032872 name: regulation of stress-activated MAPK cascade namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah] synonym: "regulation of p38 MAPK signaling" EXACT [] synonym: "regulation of p38 MAPK signalling" EXACT [] synonym: "regulation of stress-activated MAPK signaling pathway" EXACT [] synonym: "regulation of stress-activated MAPK signalling pathway" EXACT [] synonym: "regulation of stress-activated MAPKKK cascade" EXACT [] synonym: "regulation of stress-activated MAPKKK signaling pathway" EXACT [] synonym: "regulation of stress-activated MAPKKK signalling pathway" EXACT [] is_a: GO:0043408 ! regulation of MAPK cascade is_a: GO:0070302 ! regulation of stress-activated protein kinase signaling cascade intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0051403 ! stress-activated MAPK cascade relationship: regulates GO:0051403 ! stress-activated MAPK cascade [Term] id: GO:0032873 name: negative regulation of stress-activated MAPK cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah] synonym: "down regulation of stress-activated MAPK cascade" EXACT [] synonym: "down-regulation of stress-activated MAPK cascade" EXACT [] synonym: "downregulation of stress-activated MAPK cascade" EXACT [] synonym: "inhibition of stress-activated MAPK cascade" NARROW [] synonym: "negative regulation of p38 MAPK signaling" EXACT [] synonym: "negative regulation of p38 MAPK signalling" EXACT [] synonym: "negative regulation of stress-activated MAPK signaling pathway" EXACT [] synonym: "negative regulation of stress-activated MAPK signalling pathway" EXACT [] synonym: "negative regulation of stress-activated MAPKKK cascade" EXACT [] synonym: "negative regulation of stress-activated MAPKKK signaling pathway" EXACT [] synonym: "negative regulation of stress-activated MAPKKK signalling pathway" EXACT [] is_a: GO:0032872 ! regulation of stress-activated MAPK cascade is_a: GO:0043409 ! negative regulation of MAPK cascade is_a: GO:0070303 ! negative regulation of stress-activated protein kinase signaling cascade intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0051403 ! stress-activated MAPK cascade relationship: negatively_regulates GO:0051403 ! stress-activated MAPK cascade [Term] id: GO:0032874 name: positive regulation of stress-activated MAPK cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah] synonym: "activation of stress-activated MAPK cascade" NARROW [] synonym: "positive regulation of p38 MAPK signaling" EXACT [] synonym: "positive regulation of p38 MAPK signalling" EXACT [] synonym: "positive regulation of stress-activated MAPK signaling pathway" EXACT [] synonym: "positive regulation of stress-activated MAPK signalling pathway" EXACT [] synonym: "positive regulation of stress-activated MAPKKK cascade" EXACT [] synonym: "positive regulation of stress-activated MAPKKK signaling pathway" EXACT [] synonym: "positive regulation of stress-activated MAPKKK signalling pathway" EXACT [] synonym: "stimulation of stress-activated MAPK cascade" NARROW [] synonym: "up regulation of stress-activated MAPK cascade" EXACT [] synonym: "up-regulation of stress-activated MAPK cascade" EXACT [] synonym: "upregulation of stress-activated MAPK cascade" EXACT [] is_a: GO:0032872 ! regulation of stress-activated MAPK cascade is_a: GO:0043410 ! positive regulation of MAPK cascade is_a: GO:0070304 ! positive regulation of stress-activated protein kinase signaling cascade intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0051403 ! stress-activated MAPK cascade relationship: positively_regulates GO:0051403 ! stress-activated MAPK cascade [Term] id: GO:0032878 name: regulation of establishment or maintenance of cell polarity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007163 ! establishment or maintenance of cell polarity relationship: regulates GO:0007163 ! establishment or maintenance of cell polarity [Term] id: GO:0032879 name: regulation of localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah] synonym: "regulation of localisation" EXACT [GOC:mah] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0051179 ! localization relationship: regulates GO:0051179 ! localization [Term] id: GO:0032880 name: regulation of protein localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] subset: goslim_chembl synonym: "regulation of protein localisation" EXACT [GOC:mah] is_a: GO:0032879 ! regulation of localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0008104 ! protein localization relationship: regulates GO:0008104 ! protein localization [Term] id: GO:0032886 name: regulation of microtubule-based process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton." [GOC:mah] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007017 ! microtubule-based process relationship: regulates GO:0007017 ! microtubule-based process [Term] id: GO:0032924 name: activin receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:rl, GOC:signaling] synonym: "activin receptor signalling pathway" EXACT [] is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0032925 name: regulation of activin receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:BHF, GOC:rl] synonym: "regulation of activin receptor signalling pathway" EXACT [] synonym: "regulation of activin signaling pathway" RELATED [] synonym: "regulation of activin signalling pathway" RELATED [] is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0032924 ! activin receptor signaling pathway relationship: regulates GO:0032924 ! activin receptor signaling pathway [Term] id: GO:0032926 name: negative regulation of activin receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:BHF, GOC:rl] synonym: "down regulation of activin receptor signaling pathway" EXACT [] synonym: "down-regulation of activin receptor signaling pathway" EXACT [] synonym: "downregulation of activin receptor signaling pathway" EXACT [] synonym: "inhibition of activin receptor signaling pathway" NARROW [] synonym: "negative regulation of activin receptor signalling pathway" EXACT [] synonym: "negative regulation of activin signaling pathway" RELATED [] synonym: "negative regulation of activin signalling pathway" RELATED [] is_a: GO:0032925 ! regulation of activin receptor signaling pathway is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0032924 ! activin receptor signaling pathway relationship: negatively_regulates GO:0032924 ! activin receptor signaling pathway [Term] id: GO:0032927 name: positive regulation of activin receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:BHF, GOC:rl] synonym: "activation of activin receptor signaling pathway" NARROW [] synonym: "positive regulation of activin receptor signalling pathway" EXACT [] synonym: "positive regulation of activin signaling pathway" RELATED [] synonym: "positive regulation of activin signalling pathway" RELATED [] synonym: "stimulation of activin receptor signaling pathway" NARROW [] synonym: "up regulation of activin receptor signaling pathway" EXACT [] synonym: "up-regulation of activin receptor signaling pathway" EXACT [] synonym: "upregulation of activin receptor signaling pathway" EXACT [] is_a: GO:0032925 ! regulation of activin receptor signaling pathway is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0032924 ! activin receptor signaling pathway relationship: positively_regulates GO:0032924 ! activin receptor signaling pathway [Term] id: GO:0032956 name: regulation of actin cytoskeleton organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah] synonym: "regulation of actin cytoskeleton organisation" EXACT [GOC:mah] synonym: "regulation of actin cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0032970 ! regulation of actin filament-based process is_a: GO:0051493 ! regulation of cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0030036 ! actin cytoskeleton organization relationship: regulates GO:0030036 ! actin cytoskeleton organization [Term] id: GO:0032970 name: regulation of actin filament-based process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton." [GOC:mah] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0030029 ! actin filament-based process relationship: regulates GO:0030029 ! actin filament-based process [Term] id: GO:0032989 name: cellular component morphogenesis namespace: biological_process def: "The process in which cellular structures, including whole cells or cell parts, are generated and organized." [GOC:dph, GOC:mah, GOC:tb] subset: goslim_pir synonym: "cellular structure morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0016043 ! cellular component organization is_a: GO:0048869 ! cellular developmental process [Term] id: GO:0032990 name: cell part morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a cell part are generated and organized." [GOC:mah] is_a: GO:0032989 ! cellular component morphogenesis [Term] id: GO:0032991 name: protein-containing complex namespace: cellular_component alt_id: GO:0043234 def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] comment: A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole. subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_pir synonym: "macromolecular complex" EXACT [] synonym: "macromolecule complex" EXACT [] synonym: "protein complex" NARROW [] synonym: "protein containing complex" EXACT [] synonym: "protein-protein complex" NARROW [] is_a: GO:0005575 ! cellular_component [Term] id: GO:0033036 name: macromolecule localization namespace: biological_process def: "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah] subset: goslim_flybase_ribbon synonym: "macromolecule localisation" EXACT [GOC:mah] is_a: GO:0051179 ! localization [Term] id: GO:0033043 name: regulation of organelle organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] subset: goslim_yeast synonym: "regulation of organelle organisation" EXACT [GOC:mah] synonym: "regulation of organelle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006996 ! organelle organization relationship: regulates GO:0006996 ! organelle organization [Term] id: GO:0033044 name: regulation of chromosome organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah] synonym: "regulation of chromosome organisation" EXACT [GOC:mah] synonym: "regulation of chromosome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0051276 ! chromosome organization relationship: regulates GO:0051276 ! chromosome organization [Term] id: GO:0033127 name: regulation of histone phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein." [GOC:mah] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0031056 ! regulation of histone modification intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016572 ! histone phosphorylation relationship: regulates GO:0016572 ! histone phosphorylation [Term] id: GO:0033128 name: negative regulation of histone phosphorylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein." [GOC:mah] is_a: GO:0001933 ! negative regulation of protein phosphorylation is_a: GO:0031057 ! negative regulation of histone modification is_a: GO:0033127 ! regulation of histone phosphorylation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0016572 ! histone phosphorylation relationship: negatively_regulates GO:0016572 ! histone phosphorylation [Term] id: GO:0033129 name: positive regulation of histone phosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein." [GOC:mah] is_a: GO:0001934 ! positive regulation of protein phosphorylation is_a: GO:0031058 ! positive regulation of histone modification is_a: GO:0033127 ! regulation of histone phosphorylation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0016572 ! histone phosphorylation relationship: positively_regulates GO:0016572 ! histone phosphorylation [Term] id: GO:0033157 name: regulation of intracellular protein transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells." [GOC:mah] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0051223 ! regulation of protein transport is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006886 ! intracellular protein transport relationship: regulates GO:0006886 ! intracellular protein transport [Term] id: GO:0033206 name: meiotic cytokinesis namespace: biological_process def: "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] synonym: "cytokinesis after meiosis" EXACT [] is_a: GO:0061640 ! cytoskeleton-dependent cytokinesis is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0061640 ! cytoskeleton-dependent cytokinesis intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0033365 name: protein localization to organelle namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah] synonym: "protein localisation to organelle" EXACT [GOC:mah] synonym: "protein localization in organelle" EXACT [GOC:mah] is_a: GO:0034613 ! cellular protein localization [Term] id: GO:0033554 name: cellular response to stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0006950 ! response to stress is_a: GO:0051716 ! cellular response to stimulus [Term] id: GO:0033555 name: multicellular organismal response to stress namespace: biological_process def: "Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] is_a: GO:0006950 ! response to stress is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0033673 name: negative regulation of kinase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah] synonym: "down regulation of kinase activity" EXACT [] synonym: "down-regulation of kinase activity" EXACT [] synonym: "downregulation of kinase activity" EXACT [] synonym: "inhibition of kinase activity" NARROW [] synonym: "kinase inhibitor" NARROW [] is_a: GO:0042326 ! negative regulation of phosphorylation is_a: GO:0043549 ! regulation of kinase activity is_a: GO:0051348 ! negative regulation of transferase activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0016301 ! kinase activity relationship: negatively_regulates GO:0016301 ! kinase activity [Term] id: GO:0033674 name: positive regulation of kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah] synonym: "kinase activator" NARROW [] synonym: "stimulation of kinase activity" NARROW [] synonym: "up regulation of kinase activity" EXACT [] synonym: "up-regulation of kinase activity" EXACT [] synonym: "upregulation of kinase activity" EXACT [] is_a: GO:0042327 ! positive regulation of phosphorylation is_a: GO:0043549 ! regulation of kinase activity is_a: GO:0051347 ! positive regulation of transferase activity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0016301 ! kinase activity relationship: positively_regulates GO:0016301 ! kinase activity [Term] id: GO:0034062 name: 5'-3' RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 3'-end." [EC:2.7.7.6, GOC:mah, GOC:pf] synonym: "C ribonucleic acid formation factors" RELATED [EC:2.7.7.6] synonym: "C RNA formation factors" RELATED [EC:2.7.7.6] synonym: "ribonucleate nucleotidyltransferase activity" RELATED [EC:2.7.7.6] synonym: "ribonucleate polymerase activity" RELATED [EC:2.7.7.6] synonym: "ribonucleic acid nucleotidyltransferase" BROAD [EC:2.7.7.6] synonym: "ribonucleic acid polymerase activity" RELATED [EC:2.7.7.6] synonym: "ribonucleic acid transcriptase activity" RELATED [EC:2.7.7.6] synonym: "ribonucleic polymerase activity" RELATED [EC:2.7.7.6] synonym: "ribonucleic transcriptase activity" RELATED [EC:2.7.7.6] synonym: "RNA nucleotidyltransferase activity" RELATED [EC:2.7.7.6] synonym: "RNA polymerase activity" BROAD [] synonym: "RNA transcriptase activity" RELATED [EC:2.7.7.6] synonym: "transcriptase" BROAD [EC:2.7.7.6] xref: Reactome:R-HSA-5696807 "TRNT1 polymerizes CCA at the 3' end of pre-tRNA" xref: Reactome:R-HSA-6786881 "TRNT1 polymerizes CCA at the 3' end of pre-tRNA" is_a: GO:0097747 ! RNA polymerase activity [Term] id: GO:0034401 name: chromatin organization involved in regulation of transcription namespace: biological_process alt_id: GO:1903756 alt_id: GO:1903757 def: "Any cellular process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin that modulates the rate, frequency or extent of DNA-dependent transcription." [GOC:curators, PMID:21102443] synonym: "activation of global transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "establishment or maintenance of chromatin architecture during transcription" EXACT [GOC:mah] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "positive regulation of transcription from RNA polymerase II promoter by histone modification" NARROW [] synonym: "positive regulation of transcription from RNA polymerase II promoter, global by histone modification" NARROW [GOC:TermGenie] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "regulation of global transcription from Pol II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "regulation of transcription by chromatin organisation" EXACT [GOC:mah] synonym: "regulation of transcription by chromatin organization" EXACT [] synonym: "regulation of transcription from Pol II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter by histone modification" NARROW [] synonym: "regulation of transcription from RNA polymerase II promoter, global by histone modification" NARROW [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] is_a: GO:0006325 ! chromatin organization intersection_of: GO:0006325 ! chromatin organization intersection_of: part_of GO:0006355 ! regulation of transcription, DNA-templated relationship: part_of GO:0006355 ! regulation of transcription, DNA-templated created_by: rl creation_date: 2014-12-18T14:56:16Z [Term] id: GO:0034613 name: cellular protein localization namespace: biological_process alt_id: GO:0016249 def: "Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] subset: goslim_drosophila synonym: "cellular protein localisation" EXACT [GOC:mah] synonym: "channel localizer activity" NARROW [GOC:mah] is_a: GO:0008104 ! protein localization is_a: GO:0070727 ! cellular macromolecule localization [Term] id: GO:0034641 name: cellular nitrogen compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells." [GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "cellular nitrogen compound metabolism" EXACT [] is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0034645 name: cellular macromolecule biosynthetic process namespace: biological_process alt_id: GO:0034961 def: "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells." [GOC:mah] synonym: "cellular biopolymer biosynthetic process" EXACT [GOC:mtg_chebi_dec09] synonym: "cellular macromolecule anabolism" EXACT [GOC:mah] synonym: "cellular macromolecule biosynthesis" EXACT [GOC:mah] synonym: "cellular macromolecule formation" EXACT [GOC:mah] synonym: "cellular macromolecule synthesis" EXACT [GOC:mah] is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0044260 ! cellular macromolecule metabolic process [Term] id: GO:0034654 name: nucleobase-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid anabolism" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid biosynthesis" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid formation" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid synthesis" NARROW [] is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0035050 name: embryonic heart tube development namespace: biological_process def: "The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field." [GOC:go_curators] is_a: GO:0035295 ! tube development is_a: GO:0060429 ! epithelium development relationship: part_of GO:0007507 ! heart development relationship: part_of GO:0048568 ! embryonic organ development [Term] id: GO:0035082 name: axoneme assembly namespace: biological_process alt_id: GO:0035083 alt_id: GO:0035084 def: "The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194] comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. synonym: "axoneme biogenesis" RELATED [GOC:mah] synonym: "ciliary axoneme assembly" EXACT [] synonym: "cilium axoneme assembly" EXACT [] synonym: "cilium axoneme biogenesis" RELATED [GOC:mah] synonym: "flagellar axoneme assembly" EXACT [] synonym: "flagellum axoneme assembly" EXACT [] is_a: GO:0001578 ! microtubule bundle formation is_a: GO:0022607 ! cellular component assembly relationship: part_of GO:0060271 ! cilium assembly [Term] id: GO:0035088 name: establishment or maintenance of apical/basal cell polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components." [GOC:bf, GOC:mah, PMID:10934483] is_a: GO:0061245 ! establishment or maintenance of bipolar cell polarity [Term] id: GO:0035089 name: establishment of apical/basal cell polarity namespace: biological_process def: "The specification and formation of the polarity of a cell along its apical/basal axis." [GOC:bf] is_a: GO:0035088 ! establishment or maintenance of apical/basal cell polarity is_a: GO:0061162 ! establishment of monopolar cell polarity [Term] id: GO:0035148 name: tube formation namespace: biological_process def: "Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow." [GOC:bf] synonym: "lumen formation in an anatomical structure" RELATED [GOC:dph, GOC:mah] synonym: "tube lumen formation" EXACT [GOC:dph, GOC:mah] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0035239 ! tube morphogenesis [Term] id: GO:0035176 name: social behavior namespace: biological_process def: "Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group." [GOC:jh2, PMID:12848939, Wikipedia:Social_behavior] comment: Behavior such as predation which involves members of different species is not social. Communication between members of different species is also not social behavior. synonym: "cooperative behavior" RELATED [] synonym: "social behaviour" EXACT [] xref: Wikipedia:Social_behavior is_a: GO:0007610 ! behavior is_a: GO:0051703 ! biological process involved in intraspecies interaction between organisms [Term] id: GO:0035187 name: hatching behavior namespace: biological_process def: "The specific behavior of an organism during the emergence from an egg shell. In Drosophila for example, the larva swings its head reiteratively through a semicircular arc, using its mouth hooks to tear apart the chorion in front of it and thus free itself from within the egg shell." [GOC:pr, PMID:10436051] synonym: "hatching behaviour" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0035188 ! hatching [Term] id: GO:0035188 name: hatching namespace: biological_process def: "The emergence of an immature organism from a protective structure." [GOC:dgh, GOC:isa_complete, ISBN:0198612001] is_a: GO:0071684 ! organism emergence from protective structure relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0035239 name: tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0035295 ! tube development [Term] id: GO:0035265 name: organ growth namespace: biological_process def: "The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function." [GOC:bf, ISBN:0471245208, ISBN:0721662544] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0048589 ! developmental growth [Term] id: GO:0035270 name: endocrine system development namespace: biological_process def: "Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes." [GOC:bf, Wikipedia:Development_of_the_endocrine_system] is_a: GO:0048731 ! system development [Term] id: GO:0035282 name: segmentation namespace: biological_process def: "The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis." [PMID:10611687, PMID:9706689] xref: Wikipedia:Segmentation_(biology) is_a: GO:0003002 ! regionalization [Term] id: GO:0035295 name: tube development namespace: biological_process def: "The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." [PMID:12526790] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0035556 name: intracellular signal transduction namespace: biological_process alt_id: GO:0007242 alt_id: GO:0007243 alt_id: GO:0023013 alt_id: GO:0023034 def: "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] subset: goslim_drosophila synonym: "intracellular protein kinase cascade" NARROW [GOC:signaling] synonym: "intracellular signal transduction pathway" NARROW [] synonym: "intracellular signaling cascade" RELATED [GOC:signaling] synonym: "intracellular signaling chain" EXACT [ISBN:3527303782] synonym: "intracellular signaling pathway" RELATED [] synonym: "protein kinase cascade" NARROW [GOC:signaling] synonym: "signal transduction via intracellular signaling cascade" RELATED [] synonym: "signal transmission via intracellular cascade" NARROW [] is_a: GO:0007165 ! signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: occurs_in GO:0005622 ! intracellular anatomical structure relationship: occurs_in GO:0005622 ! intracellular anatomical structure created_by: bf creation_date: 2010-05-14T01:14:37Z [Term] id: GO:0035567 name: non-canonical Wnt signaling pathway namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin." [GOC:signaling] comment: This term should only be used when Wnt receptor signaling occurs via a beta-catenin-independent route but the downstream effectors are unknown. If the downstream effectors are known, consider instead annotating to one of the children, or requesting a new term. synonym: "beta-catenin-independent Wnt receptor signaling pathway" EXACT [GOC:signaling] synonym: "non-canonical Wnt receptor signaling pathway" EXACT [] synonym: "non-canonical Wnt receptor signalling pathway" EXACT [GOC:mah] synonym: "non-canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] is_a: GO:0016055 ! Wnt signaling pathway created_by: bf creation_date: 2010-07-23T02:26:01Z [Term] id: GO:0035735 name: intraciliary transport involved in cilium assembly namespace: biological_process def: "The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly." [GOC:bf, GOC:cilia, Reactome:R-HSA-5620924.2] synonym: "intraciliary transport involved in cilium morphogenesis" RELATED [] synonym: "intraflagellar transport" BROAD [] synonym: "intraflagellar transport involved in cilium morphogenesis" RELATED [] xref: Reactome:R-HSA-5620924.2 is_a: GO:0042073 ! intraciliary transport intersection_of: GO:0042073 ! intraciliary transport intersection_of: part_of GO:0060271 ! cilium assembly relationship: part_of GO:0060271 ! cilium assembly created_by: bf creation_date: 2011-03-17T10:55:42Z [Term] id: GO:0035883 name: enteroendocrine cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system." [CL:0000164, GOC:bf] is_a: GO:0002067 ! glandular epithelial cell differentiation created_by: bf creation_date: 2011-06-06T11:48:51Z [Term] id: GO:0036211 name: protein modification process namespace: biological_process def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl] synonym: "protein modification" EXACT [GOC:bf] is_a: GO:0019538 ! protein metabolic process is_a: GO:0043412 ! macromolecule modification created_by: bf creation_date: 2012-04-26T01:47:12Z [Term] id: GO:0036269 name: swimming behavior namespace: biological_process def: "The response to external or internal stimuli that results in the locomotory process of swimming. Swimming is the self-propelled movement of an organism through the water." [GOC:cvs, PMID:16764679] synonym: "swimming behaviour" EXACT [PMID:16764679] is_a: GO:0007626 ! locomotory behavior created_by: bf creation_date: 2012-07-04T10:14:49Z [Term] id: GO:0038092 name: nodal signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of a nodal protein to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:vk, PMID:17287255] synonym: "nodal signaling" EXACT [GOC:bf] synonym: "nodal signalling pathway" EXACT [GOC:mah] is_a: GO:0032924 ! activin receptor signaling pathway created_by: bf creation_date: 2012-02-16T02:44:02Z [Term] id: GO:0038107 name: nodal signaling pathway involved in determination of left/right asymmetry namespace: biological_process def: "A series of molecular signals initiated by the binding of a nodal protein to an activin receptor on the surface of a target cell, which contributes to the establishment of an organism's body plan or part of an organism with respect to the left and right halves." [GOC:BHF, GOC:vk, PMID:12857784, PMID:17287255, PMID:20413706] synonym: "nodal signalling pathway involved in determination of left/right asymmetry" EXACT [GOC:mah] synonym: "regulation of transcription from RNA polymerase II promoter by nodal signaling pathway, involved in determination of left/right symmetry" EXACT [GOC:bf] is_a: GO:0038092 ! nodal signaling pathway is_a: GO:1900094 ! regulation of transcription from RNA polymerase II promoter involved in determination of left/right symmetry intersection_of: GO:0038092 ! nodal signaling pathway intersection_of: part_of GO:0007368 ! determination of left/right symmetry created_by: bf creation_date: 2012-02-29T10:18:59Z [Term] id: GO:0040007 name: growth namespace: biological_process alt_id: GO:0048590 def: "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] comment: See also the biological process term 'cell growth ; GO:0016049'. subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant synonym: "growth pattern" RELATED [] synonym: "non-developmental growth" RELATED [GOC:mah] is_a: GO:0008150 ! biological_process [Term] id: GO:0040008 name: regulation of growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0040007 ! growth relationship: regulates GO:0040007 ! growth [Term] id: GO:0040009 name: regulation of growth rate namespace: biological_process def: "Any process that modulates the rate of growth of all or part of an organism." [GOC:mah] comment: Note that this term and its definition depart from the usual conventions for GO 'regulation' process terms; regulation of rate is not usually distinguished from regulation of extent or frequency, but it makes sense to do so for growth regulation. is_a: GO:0040008 ! regulation of growth [Term] id: GO:0040011 name: locomotion namespace: biological_process def: "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] subset: goslim_chembl subset: goslim_generic subset: goslim_pir is_a: GO:0008150 ! biological_process property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0040012 name: regulation of locomotion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of locomotion of a cell or organism." [GOC:ems] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0040011 ! locomotion relationship: regulates GO:0040011 ! locomotion [Term] id: GO:0040013 name: negative regulation of locomotion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators] synonym: "down regulation of locomotion" EXACT [] synonym: "down-regulation of locomotion" EXACT [] synonym: "downregulation of locomotion" EXACT [] synonym: "inhibition of locomotion" NARROW [] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0040011 ! locomotion relationship: negatively_regulates GO:0040011 ! locomotion [Term] id: GO:0040017 name: positive regulation of locomotion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators] synonym: "activation of locomotion" NARROW [] synonym: "stimulation of locomotion" NARROW [] synonym: "up regulation of locomotion" EXACT [] synonym: "up-regulation of locomotion" EXACT [] synonym: "upregulation of locomotion" EXACT [] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0040011 ! locomotion relationship: positively_regulates GO:0040011 ! locomotion [Term] id: GO:0040019 name: positive regulation of embryonic development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of embryonic development." [GOC:go_curators] synonym: "activation of embryonic development" NARROW [] synonym: "stimulation of embryonic development" NARROW [] synonym: "up regulation of embryonic development" EXACT [] synonym: "up-regulation of embryonic development" EXACT [] synonym: "upregulation of embryonic development" EXACT [] is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009790 ! embryo development relationship: positively_regulates GO:0009790 ! embryo development [Term] id: GO:0040020 name: regulation of meiotic nuclear division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes." [GOC:ems, GOC:ma] synonym: "regulation of meiosis" BROAD [GOC:vw] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0051445 ! regulation of meiotic cell cycle is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0140013 ! meiotic nuclear division relationship: regulates GO:0140013 ! meiotic nuclear division [Term] id: GO:0040036 name: regulation of fibroblast growth factor receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators] synonym: "regulation of FGF receptor signaling pathway" EXACT [] synonym: "regulation of FGF receptor signalling pathway" EXACT [] synonym: "regulation of FGFR signaling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway relationship: regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway [Term] id: GO:0040037 name: negative regulation of fibroblast growth factor receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators] synonym: "down regulation of fibroblast growth factor receptor signaling pathway" EXACT [] synonym: "down-regulation of fibroblast growth factor receptor signaling pathway" EXACT [] synonym: "downregulation of fibroblast growth factor receptor signaling pathway" EXACT [] synonym: "inhibition of fibroblast growth factor receptor signaling pathway" NARROW [] synonym: "negative regulation of FGF receptor signaling pathway" EXACT [] synonym: "negative regulation of FGF receptor signalling pathway" EXACT [] synonym: "negative regulation of FGFR signaling pathway" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0040036 ! regulation of fibroblast growth factor receptor signaling pathway is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway relationship: negatively_regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway [Term] id: GO:0042048 name: olfactory behavior namespace: biological_process def: "The behavior of an organism in response to an odor." [GOC:jid, GOC:pr] synonym: "behavioral response to scent" EXACT [] synonym: "behavioral response to smell" EXACT [] synonym: "behavioural response to odour" EXACT [] synonym: "behavioural response to scent" EXACT [] synonym: "behavioural response to smell" EXACT [] synonym: "olfactory behaviour" EXACT [] is_a: GO:0007635 ! chemosensory behavior [Term] id: GO:0042060 name: wound healing namespace: biological_process def: "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] xref: Wikipedia:Wound_healing is_a: GO:0009611 ! response to wounding [Term] id: GO:0042073 name: intraciliary transport namespace: biological_process alt_id: GO:0035734 def: "The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374, Reactome:R-HSA-5620924.2] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "IFT" RELATED [] synonym: "intraflagellar transport" EXACT [] synonym: "intraflagellar transport involved in cilium organization" EXACT [] synonym: "intraflagellar transport involved in microtubule-based flagellum organisation" EXACT [] xref: Wikipedia:Intraflagellar_transport is_a: GO:0031503 ! protein-containing complex localization is_a: GO:0098840 ! protein transport along microtubule relationship: occurs_in GO:0005929 ! cilium relationship: part_of GO:0044782 ! cilium organization property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3312 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0042074 name: cell migration involved in gastrulation namespace: biological_process def: "The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression)." [GOC:jl, http://www.cellmigration.org/, ISBN:0878932437] is_a: GO:0001667 ! ameboidal-type cell migration intersection_of: GO:0016477 ! cell migration intersection_of: part_of GO:0007369 ! gastrulation relationship: part_of GO:0007369 ! gastrulation [Term] id: GO:0042127 name: regulation of cell population proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] synonym: "regulation of cell proliferation" RELATED [] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0008283 ! cell population proliferation relationship: regulates GO:0008283 ! cell population proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0042221 name: response to chemical namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_drosophila subset: goslim_metagenomics subset: goslim_plant subset: goslim_yeast synonym: "response to chemical stimulus" EXACT [GOC:dos] synonym: "response to chemical substance" EXACT [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0042249 name: establishment of planar polarity of embryonic epithelium namespace: biological_process def: "Coordinated organization of groups of cells in the plane of an embryonic epithelium, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:dph, GOC:jl, GOC:tb] is_a: GO:0001736 ! establishment of planar polarity [Term] id: GO:0042325 name: regulation of phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl] is_a: GO:0019220 ! regulation of phosphate metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016310 ! phosphorylation relationship: regulates GO:0016310 ! phosphorylation [Term] id: GO:0042326 name: negative regulation of phosphorylation namespace: biological_process def: "Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule." [GOC:jl] synonym: "down regulation of phosphorylation" EXACT [] synonym: "down-regulation of phosphorylation" EXACT [] synonym: "downregulation of phosphorylation" EXACT [] synonym: "inhibition of phosphorylation" NARROW [] is_a: GO:0042325 ! regulation of phosphorylation is_a: GO:0045936 ! negative regulation of phosphate metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0016310 ! phosphorylation relationship: negatively_regulates GO:0016310 ! phosphorylation [Term] id: GO:0042327 name: positive regulation of phosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." [GOC:jl] synonym: "activation of phosphorylation" NARROW [] synonym: "stimulation of phosphorylation" NARROW [] synonym: "up regulation of phosphorylation" EXACT [] synonym: "up-regulation of phosphorylation" EXACT [] synonym: "upregulation of phosphorylation" EXACT [] is_a: GO:0042325 ! regulation of phosphorylation is_a: GO:0045937 ! positive regulation of phosphate metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0016310 ! phosphorylation relationship: positively_regulates GO:0016310 ! phosphorylation [Term] id: GO:0042330 name: taxis namespace: biological_process def: "The directed movement of a motile cell or organism in response to an external stimulus." [GOC:jl, ISBN:0192801023] synonym: "directed movement in response to stimulus" EXACT [] xref: Wikipedia:Taxis is_a: GO:0040011 ! locomotion relationship: part_of GO:0009605 ! response to external stimulus [Term] id: GO:0042403 name: thyroid hormone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." [GOC:jl, ISBN:0198506732] synonym: "thyroid hormone metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0042445 ! hormone metabolic process [Term] id: GO:0042445 name: hormone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl] subset: goslim_pir synonym: "hormone metabolism" EXACT [] is_a: GO:0008152 ! metabolic process is_a: GO:0010817 ! regulation of hormone levels property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0042692 name: muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a muscle cell." [CL:0000187, GOC:go_curators] synonym: "myogenesis" RELATED [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0061061 ! muscle structure development [Term] id: GO:0042886 name: amide transport namespace: biological_process def: "The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732] subset: goslim_pir is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0042981 name: regulation of apoptotic process namespace: biological_process def: "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. synonym: "apoptosis regulator activity" RELATED [] synonym: "regulation of apoptosis" NARROW [] is_a: GO:0043067 ! regulation of programmed cell death intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006915 ! apoptotic process relationship: regulates GO:0006915 ! apoptotic process [Term] id: GO:0042995 name: cell projection namespace: cellular_component def: "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, http://www.cogsci.princeton.edu/~wn/] subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir synonym: "cell process" BROAD [] synonym: "cellular process" BROAD [] synonym: "cellular projection" EXACT [] is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0043009 name: chordate embryonic development namespace: biological_process def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching." [GOC:mtg_sensu] is_a: GO:0009792 ! embryo development ending in birth or egg hatching [Term] id: GO:0043065 name: positive regulation of apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is positively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. subset: goslim_chembl synonym: "activation of apoptosis" NARROW [] synonym: "positive regulation of apoptosis" NARROW [] synonym: "pro-apoptosis" RELATED [] synonym: "stimulation of apoptosis" NARROW [] synonym: "up regulation of apoptosis" EXACT [] synonym: "up-regulation of apoptosis" EXACT [] synonym: "upregulation of apoptosis" EXACT [] is_a: GO:0042981 ! regulation of apoptotic process is_a: GO:0043068 ! positive regulation of programmed cell death intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006915 ! apoptotic process relationship: positively_regulates GO:0006915 ! apoptotic process [Term] id: GO:0043066 name: negative regulation of apoptotic process namespace: biological_process alt_id: GO:0006916 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is negatively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. synonym: "anti-apoptosis" EXACT [] synonym: "apoptosis inhibitor activity" RELATED [] synonym: "down regulation of apoptosis" EXACT [] synonym: "down-regulation of apoptosis" EXACT [] synonym: "downregulation of apoptosis" EXACT [] synonym: "inhibition of apoptosis" NARROW [] synonym: "negative regulation of apoptosis" NARROW [] synonym: "pro-survival" RELATED [] is_a: GO:0042981 ! regulation of apoptotic process is_a: GO:0043069 ! negative regulation of programmed cell death intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006915 ! apoptotic process relationship: negatively_regulates GO:0006915 ! apoptotic process [Term] id: GO:0043067 name: regulation of programmed cell death namespace: biological_process alt_id: GO:0043070 def: "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] synonym: "regulation of non-apoptotic programmed cell death" NARROW [] is_a: GO:0010941 ! regulation of cell death intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0012501 ! programmed cell death relationship: regulates GO:0012501 ! programmed cell death [Term] id: GO:0043068 name: positive regulation of programmed cell death namespace: biological_process alt_id: GO:0043071 def: "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] synonym: "activation of programmed cell death" NARROW [] synonym: "positive regulation of non-apoptotic programmed cell death" NARROW [] synonym: "stimulation of programmed cell death" NARROW [] synonym: "up regulation of programmed cell death" EXACT [] synonym: "up-regulation of programmed cell death" EXACT [] synonym: "upregulation of programmed cell death" EXACT [] is_a: GO:0010942 ! positive regulation of cell death is_a: GO:0043067 ! regulation of programmed cell death intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0012501 ! programmed cell death relationship: positively_regulates GO:0012501 ! programmed cell death [Term] id: GO:0043069 name: negative regulation of programmed cell death namespace: biological_process alt_id: GO:0043072 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] synonym: "down regulation of programmed cell death" EXACT [] synonym: "down-regulation of programmed cell death" EXACT [] synonym: "downregulation of programmed cell death" EXACT [] synonym: "inhibition of programmed cell death" NARROW [] synonym: "negative regulation of non-apoptotic programmed cell death" NARROW [] is_a: GO:0043067 ! regulation of programmed cell death is_a: GO:0060548 ! negative regulation of cell death intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0012501 ! programmed cell death relationship: negatively_regulates GO:0012501 ! programmed cell death [Term] id: GO:0043085 name: positive regulation of catalytic activity namespace: biological_process alt_id: GO:0048554 def: "Any process that activates or increases the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw] subset: goslim_chembl synonym: "activation of enzyme activity" NARROW [] synonym: "activation of metalloenzyme activity" NARROW [] synonym: "positive regulation of enzyme activity" EXACT [GOC:tb] synonym: "positive regulation of metalloenzyme activity" NARROW [] synonym: "stimulation of enzyme activity" NARROW [] synonym: "stimulation of metalloenzyme activity" NARROW [] synonym: "up regulation of enzyme activity" EXACT [] synonym: "up regulation of metalloenzyme activity" NARROW [] synonym: "up-regulation of enzyme activity" EXACT [] synonym: "up-regulation of metalloenzyme activity" NARROW [] synonym: "upregulation of enzyme activity" EXACT [] synonym: "upregulation of metalloenzyme activity" NARROW [] is_a: GO:0044093 ! positive regulation of molecular function is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0003824 ! catalytic activity relationship: positively_regulates GO:0003824 ! catalytic activity [Term] id: GO:0043086 name: negative regulation of catalytic activity namespace: biological_process alt_id: GO:0048553 def: "Any process that stops or reduces the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw] synonym: "down regulation of enzyme activity" EXACT [] synonym: "down regulation of metalloenzyme activity" NARROW [] synonym: "down-regulation of enzyme activity" EXACT [] synonym: "down-regulation of metalloenzyme activity" EXACT [] synonym: "downregulation of enzyme activity" EXACT [] synonym: "downregulation of metalloenzyme activity" NARROW [] synonym: "inhibition of enzyme activity" NARROW [] synonym: "inhibition of metalloenzyme activity" NARROW [] synonym: "negative regulation of enzyme activity" EXACT [GOC:tb] synonym: "negative regulation of metalloenzyme activity" NARROW [] is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0003824 ! catalytic activity relationship: negatively_regulates GO:0003824 ! catalytic activity [Term] id: GO:0043154 name: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process namespace: biological_process alt_id: GO:0001719 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis] synonym: "down regulation of caspase activity" EXACT [] synonym: "down-regulation of caspase activity" EXACT [] synonym: "downregulation of caspase activity" EXACT [] synonym: "inhibition of caspase activation" NARROW [] synonym: "inhibition of caspase activity" NARROW [] synonym: "negative regulation of caspase activation" EXACT [] synonym: "negative regulation of caspase activity" BROAD [] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:0043281 ! regulation of cysteine-type endopeptidase activity involved in apoptotic process is_a: GO:2000117 ! negative regulation of cysteine-type endopeptidase activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0097153 ! cysteine-type endopeptidase activity involved in apoptotic process relationship: negatively_regulates GO:0097153 ! cysteine-type endopeptidase activity involved in apoptotic process [Term] id: GO:0043170 name: macromolecule metabolic process namespace: biological_process alt_id: GO:0043283 alt_id: GO:0044259 def: "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] subset: goslim_pir synonym: "biopolymer metabolic process" EXACT [GOC:mtg_chebi_dec09] synonym: "macromolecule metabolism" EXACT [] synonym: "multicellular organismal macromolecule metabolic process" NARROW [] synonym: "organismal macromolecule metabolism" EXACT [] is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0043226 name: organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] subset: goslim_chembl subset: goslim_generic subset: goslim_pir xref: NIF_Subcellular:sao1539965131 xref: Wikipedia:Organelle is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0043227 name: membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] synonym: "membrane-enclosed organelle" EXACT [] xref: NIF_Subcellular:sao414196390 is_a: GO:0043226 ! organelle [Term] id: GO:0043228 name: non-membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] synonym: "non-membrane-enclosed organelle" EXACT [] xref: NIF_Subcellular:sao1456184038 is_a: GO:0043226 ! organelle [Term] id: GO:0043229 name: intracellular organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] subset: goslim_pir is_a: GO:0005622 ! intracellular anatomical structure [Term] id: GO:0043231 name: intracellular membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] subset: goslim_pir synonym: "intracellular membrane-enclosed organelle" EXACT [] is_a: GO:0043227 ! membrane-bounded organelle is_a: GO:0043229 ! intracellular organelle [Term] id: GO:0043232 name: intracellular non-membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] subset: goslim_mouse subset: goslim_pir synonym: "intracellular non-membrane-enclosed organelle" EXACT [] is_a: GO:0043228 ! non-membrane-bounded organelle is_a: GO:0043229 ! intracellular organelle intersection_of: GO:0043228 ! non-membrane-bounded organelle intersection_of: part_of GO:0005622 ! intracellular anatomical structure relationship: part_of GO:0005622 ! intracellular anatomical structure [Term] id: GO:0043269 name: regulation of ion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006811 ! ion transport relationship: regulates GO:0006811 ! ion transport [Term] id: GO:0043270 name: positive regulation of ion transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] synonym: "activation of ion transport" NARROW [] synonym: "stimulation of ion transport" NARROW [] synonym: "up regulation of ion transport" EXACT [] synonym: "up-regulation of ion transport" EXACT [] synonym: "upregulation of ion transport" EXACT [] is_a: GO:0043269 ! regulation of ion transport is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006811 ! ion transport relationship: positively_regulates GO:0006811 ! ion transport [Term] id: GO:0043271 name: negative regulation of ion transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] synonym: "down regulation of ion transport" EXACT [] synonym: "down-regulation of ion transport" EXACT [] synonym: "downregulation of ion transport" EXACT [] synonym: "inhibition of ion transport" NARROW [] is_a: GO:0043269 ! regulation of ion transport is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006811 ! ion transport relationship: negatively_regulates GO:0006811 ! ion transport [Term] id: GO:0043280 name: positive regulation of cysteine-type endopeptidase activity involved in apoptotic process namespace: biological_process def: "Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis] synonym: "activation of caspase activity" NARROW [] synonym: "positive regulation of caspase activity" BROAD [] synonym: "stimulation of caspase activity" NARROW [] synonym: "up regulation of caspase activity" EXACT [] synonym: "up-regulation of caspase activity" EXACT [] synonym: "upregulation of caspase activity" EXACT [] is_a: GO:0043281 ! regulation of cysteine-type endopeptidase activity involved in apoptotic process is_a: GO:2001056 ! positive regulation of cysteine-type endopeptidase activity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0097153 ! cysteine-type endopeptidase activity involved in apoptotic process relationship: positively_regulates GO:0097153 ! cysteine-type endopeptidase activity involved in apoptotic process [Term] id: GO:0043281 name: regulation of cysteine-type endopeptidase activity involved in apoptotic process namespace: biological_process alt_id: GO:0043026 def: "Any process that modulates the activity of a cysteine-type endopeptidase involved in apoptosis." [GOC:jl, GOC:mtg_apoptosis] synonym: "regulation of caspase activation" NARROW [] synonym: "regulation of caspase activity" BROAD [] is_a: GO:2000116 ! regulation of cysteine-type endopeptidase activity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0097153 ! cysteine-type endopeptidase activity involved in apoptotic process relationship: regulates GO:0097153 ! cysteine-type endopeptidase activity involved in apoptotic process [Term] id: GO:0043405 name: regulation of MAP kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators] synonym: "Regulation of MAPK activity" EXACT [GOC:dph] synonym: "regulation of mitogen activated protein kinase activity" EXACT [] synonym: "regulation of mitogen-activated protein kinase activity" EXACT [] is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0004707 ! MAP kinase activity relationship: regulates GO:0004707 ! MAP kinase activity [Term] id: GO:0043406 name: positive regulation of MAP kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators] synonym: "positive regulation of mitogen activated protein kinase activity" EXACT [] synonym: "positive regulation of mitogen-activated protein kinase activity" EXACT [] synonym: "stimulation of MAPK activity" NARROW [] synonym: "up regulation of MAPK activity" EXACT [] synonym: "up-regulation of MAPK activity" EXACT [] synonym: "upregulation of MAPK activity" EXACT [] is_a: GO:0043405 ! regulation of MAP kinase activity is_a: GO:0043410 ! positive regulation of MAPK cascade is_a: GO:0071902 ! positive regulation of protein serine/threonine kinase activity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0004707 ! MAP kinase activity relationship: positively_regulates GO:0004707 ! MAP kinase activity [Term] id: GO:0043407 name: negative regulation of MAP kinase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators] synonym: "down regulation of MAPK activity" EXACT [] synonym: "down-regulation of MAPK activity" EXACT [] synonym: "downregulation of MAPK activity" EXACT [] synonym: "inhibition of MAPK activity" NARROW [] synonym: "negative regulation of mitogen activated protein kinase activity" EXACT [] synonym: "negative regulation of mitogen-activated protein kinase activity" EXACT [] is_a: GO:0043405 ! regulation of MAP kinase activity is_a: GO:0043409 ! negative regulation of MAPK cascade is_a: GO:0071901 ! negative regulation of protein serine/threonine kinase activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0004707 ! MAP kinase activity relationship: negatively_regulates GO:0004707 ! MAP kinase activity [Term] id: GO:0043408 name: regulation of MAPK cascade namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade." [GOC:go_curators] synonym: "regulation of MAP kinase cascade" EXACT [GOC:signaling] synonym: "regulation of MAP kinase kinase kinase cascade" EXACT [] synonym: "regulation of MAPKKK cascade" EXACT [GOC:signaling] synonym: "regulation of mitogen activated protein kinase cascade" EXACT [GOC:signaling] synonym: "regulation of mitogen activated protein kinase kinase kinase cascade" EXACT [] synonym: "regulation of mitogen-activated protein kinase cascade" EXACT [GOC:signaling] synonym: "regulation of mitogen-activated protein kinase kinase kinase cascade" EXACT [] is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0000165 ! MAPK cascade relationship: regulates GO:0000165 ! MAPK cascade [Term] id: GO:0043409 name: negative regulation of MAPK cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade." [GOC:go_curators] synonym: "down regulation of MAPK cascade" EXACT [GOC:signaling] synonym: "down regulation of MAPKKK cascade" EXACT [] synonym: "down-regulation of MAPK cascade" EXACT [GOC:signaling] synonym: "down-regulation of MAPKKK cascade" EXACT [] synonym: "downregulation of MAPK cascade" EXACT [GOC:signaling] synonym: "downregulation of MAPKKK cascade" EXACT [] synonym: "inhibition of MAPK cascade" NARROW [GOC:signaling] synonym: "inhibition of MAPKKK cascade" NARROW [] synonym: "negative regulation of MAP kinase cascade" EXACT [GOC:signaling] synonym: "negative regulation of MAP kinase kinase kinase cascade" EXACT [] synonym: "negative regulation of MAPKKK cascade" EXACT [GOC:signaling] synonym: "negative regulation of mitogen activated protein kinase cascade" EXACT [GOC:signaling] synonym: "negative regulation of mitogen activated protein kinase kinase kinase cascade" EXACT [] synonym: "negative regulation of mitogen-activated protein kinase cascade" EXACT [GOC:signaling] synonym: "negative regulation of mitogen-activated protein kinase kinase kinase cascade" EXACT [] is_a: GO:0043408 ! regulation of MAPK cascade is_a: GO:1902532 ! negative regulation of intracellular signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0000165 ! MAPK cascade relationship: negatively_regulates GO:0000165 ! MAPK cascade [Term] id: GO:0043410 name: positive regulation of MAPK cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade." [GOC:go_curators] synonym: "activation of MAPK cascade" NARROW [GOC:signaling] synonym: "activation of MAPKKK cascade" NARROW [] synonym: "positive regulation of MAP kinase cascade" EXACT [GOC:signaling] synonym: "positive regulation of MAP kinase kinase kinase cascade" EXACT [] synonym: "positive regulation of MAPKKK cascade" EXACT [GOC:signaling] synonym: "positive regulation of mitogen activated protein kinase kinase kinase cascade" EXACT [] synonym: "positive regulation of mitogen-activated protein kinase cascade" EXACT [GOC:signaling] synonym: "positive regulation of mitogen-activated protein kinase kinase kinase cascade" EXACT [] synonym: "stimulation of MAPK cascade" EXACT [GOC:signaling] synonym: "stimulation of MAPKKK cascade" NARROW [] synonym: "up regulation of MAPKKK cascade" EXACT [] synonym: "up-regulation of MAPK cascade" EXACT [GOC:signaling] synonym: "up-regulation of MAPKKK cascade" EXACT [] synonym: "upregulation of MAPK cascade" EXACT [GOC:signaling] synonym: "upregulation of MAPKKK cascade" EXACT [] is_a: GO:0043408 ! regulation of MAPK cascade is_a: GO:1902533 ! positive regulation of intracellular signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0000165 ! MAPK cascade relationship: positively_regulates GO:0000165 ! MAPK cascade [Term] id: GO:0043412 name: macromolecule modification namespace: biological_process def: "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators] subset: goslim_pir is_a: GO:0043170 ! macromolecule metabolic process [Term] id: GO:0043414 name: macromolecule methylation namespace: biological_process def: "The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule." [GOC:go_curators] is_a: GO:0032259 ! methylation is_a: GO:0043412 ! macromolecule modification is_a: GO:0044260 ! cellular macromolecule metabolic process [Term] id: GO:0043434 name: response to peptide hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone] synonym: "response to peptide hormone stimulus" EXACT [GOC:dos] synonym: "response to polypeptide hormone stimulus" EXACT [] is_a: GO:0009725 ! response to hormone is_a: GO:1901652 ! response to peptide [Term] id: GO:0043473 name: pigmentation namespace: biological_process def: "The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells." [GOC:jl] subset: goslim_chembl subset: goslim_generic subset: goslim_pir is_a: GO:0008150 ! biological_process [Term] id: GO:0043476 name: pigment accumulation namespace: biological_process def: "The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to some external stimulus." [GOC:jl] synonym: "pigment accumulation in response to external stimulus" EXACT [] is_a: GO:0009605 ! response to external stimulus is_a: GO:0043473 ! pigmentation [Term] id: GO:0043480 name: pigment accumulation in tissues namespace: biological_process def: "The aggregation of coloring matter in a particular location in a tissue, occurring in response to an external stimulus." [GOC:jl] synonym: "organismal pigment accumulation" EXACT [] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0043476 ! pigment accumulation [Term] id: GO:0043491 name: protein kinase B signaling namespace: biological_process def: "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound." [GOC:bf, PMID:20517722] synonym: "AKT signal transduction" EXACT [GOC:signaling] synonym: "AKT signaling" EXACT [GOC:signaling] synonym: "AKT signaling cascade" RELATED [] synonym: "AKT signalling cascade" EXACT [] synonym: "PKB signal transduction" EXACT [GOC:signaling] synonym: "PKB signaling" EXACT [GOC:signaling] synonym: "PKB signaling cascade" RELATED [] synonym: "PKB signalling cascade" RELATED [] synonym: "protein kinase B signal transduction" EXACT [GOC:signaling] synonym: "protein kinase B signaling cascade" RELATED [GOC:signaling] synonym: "protein kinase B signalling cascade" RELATED [] is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0043543 name: protein acylation namespace: biological_process def: "The addition of an acyl group, any group or radical of the form RCO- where R is an organic group, to a protein amino acid." [GOC:jl] subset: goslim_yeast synonym: "protein amino acid acylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0043549 name: regulation of kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:bf] is_a: GO:0042325 ! regulation of phosphorylation is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016301 ! kinase activity relationship: regulates GO:0016301 ! kinase activity [Term] id: GO:0043900 name: regulation of multi-organism process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species." [GOC:jl] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0051704 ! multi-organism process relationship: regulates GO:0051704 ! multi-organism process [Term] id: GO:0043901 name: negative regulation of multi-organism process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species." [GOC:jl] is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0051704 ! multi-organism process relationship: negatively_regulates GO:0051704 ! multi-organism process [Term] id: GO:0043902 name: positive regulation of multi-organism process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species." [GOC:jl] is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0051704 ! multi-organism process relationship: positively_regulates GO:0051704 ! multi-organism process [Term] id: GO:0044057 name: regulation of system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system." [GOC:jl] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0003008 ! system process relationship: regulates GO:0003008 ! system process [Term] id: GO:0044070 name: regulation of anion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] is_a: GO:0043269 ! regulation of ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006820 ! anion transport relationship: regulates GO:0006820 ! anion transport [Term] id: GO:0044085 name: cellular component biogenesis namespace: biological_process alt_id: GO:0071843 def: "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah] subset: goslim_pir synonym: "cellular component biogenesis at cellular level" EXACT [] is_a: GO:0071840 ! cellular component organization or biogenesis [Term] id: GO:0044087 name: regulation of cellular component biogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0044085 ! cellular component biogenesis relationship: regulates GO:0044085 ! cellular component biogenesis [Term] id: GO:0044089 name: positive regulation of cellular component biogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0044085 ! cellular component biogenesis relationship: positively_regulates GO:0044085 ! cellular component biogenesis [Term] id: GO:0044092 name: negative regulation of molecular function namespace: biological_process def: "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0003674 ! molecular_function relationship: negatively_regulates GO:0003674 ! molecular_function created_by: jl creation_date: 2009-04-21T04:07:27Z [Term] id: GO:0044093 name: positive regulation of molecular function namespace: biological_process def: "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0003674 ! molecular_function relationship: positively_regulates GO:0003674 ! molecular_function created_by: jl creation_date: 2009-04-21T04:11:06Z [Term] id: GO:0044237 name: cellular metabolic process namespace: biological_process def: "The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators] synonym: "cellular metabolism" EXACT [] synonym: "intermediary metabolism" RELATED [GOC:mah] is_a: GO:0008152 ! metabolic process is_a: GO:0009987 ! cellular process [Term] id: GO:0044238 name: primary metabolic process namespace: biological_process def: "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators, http://www.metacyc.org] subset: goslim_pir synonym: "primary metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0044249 name: cellular biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl] synonym: "cellular anabolism" EXACT [] synonym: "cellular biosynthesis" EXACT [] synonym: "cellular formation" EXACT [] synonym: "cellular synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0044260 name: cellular macromolecule metabolic process namespace: biological_process alt_id: GO:0034960 def: "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells." [GOC:mah] synonym: "cellular biopolymer metabolic process" EXACT [GOC:mtg_chebi_dec09] synonym: "cellular macromolecule metabolism" EXACT [] is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0044267 name: cellular protein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl] synonym: "cellular protein metabolism" EXACT [] is_a: GO:0019538 ! protein metabolic process is_a: GO:0044260 ! cellular macromolecule metabolic process [Term] id: GO:0044271 name: cellular nitrogen compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732] synonym: "nitrogen compound anabolism" BROAD [] synonym: "nitrogen compound biosynthesis" BROAD [] synonym: "nitrogen compound formation" BROAD [] synonym: "nitrogen compound synthesis" BROAD [] is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0044324 name: regulation of transcription involved in anterior/posterior axis specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription that contributes to the specification of the anterior/posterior axis." [GOC:jl] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: part_of GO:0009948 ! anterior/posterior axis specification relationship: part_of GO:0009948 ! anterior/posterior axis specification created_by: jl creation_date: 2010-08-04T12:35:41Z [Term] id: GO:0044330 name: canonical Wnt signaling pathway involved in positive regulation of wound healing namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in positive regulation of wound healing." [GOC:BHF, GOC:jl] synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of wound healing" EXACT [] synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of wound healing" EXACT [GOC:mah] synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of wound healing" EXACT [GOC:signaling] is_a: GO:0060070 ! canonical Wnt signaling pathway intersection_of: GO:0060070 ! canonical Wnt signaling pathway intersection_of: part_of GO:0090303 ! positive regulation of wound healing relationship: part_of GO:0090303 ! positive regulation of wound healing created_by: jl creation_date: 2010-08-18T04:21:21Z [Term] id: GO:0044332 name: Wnt signaling pathway involved in dorsal/ventral axis specification namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the establishment, maintenance and elaboration of the dorsal/ventral axis." [GOC:jl, GOC:yaf] synonym: "Wnt receptor signaling pathway involved in dorsal/ventral axis specification" EXACT [] synonym: "Wnt receptor signalling pathway involved in dorsal/ventral axis specification" EXACT [GOC:mah] synonym: "Wnt-activated signaling pathway involved in dorsal/ventral axis specification" EXACT [GOC:signaling] is_a: GO:0016055 ! Wnt signaling pathway intersection_of: GO:0016055 ! Wnt signaling pathway intersection_of: part_of GO:0009950 ! dorsal/ventral axis specification relationship: part_of GO:0009950 ! dorsal/ventral axis specification created_by: jl creation_date: 2010-08-20T11:30:30Z [Term] id: GO:0044336 name: canonical Wnt signaling pathway involved in negative regulation of apoptotic process namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the negative regulation of apoptotic process." [GOC:BHF, GOC:jl, GOC:mtg_apoptosis] synonym: "canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis" NARROW [] synonym: "canonical Wnt receptor signaling pathway involved in negative regulation of apoptotic process" EXACT [GOC:signaling] synonym: "canonical Wnt receptor signalling pathway involved in negative regulation of apoptosis" EXACT [GOC:mah] is_a: GO:0060070 ! canonical Wnt signaling pathway intersection_of: GO:0060070 ! canonical Wnt signaling pathway intersection_of: part_of GO:0043066 ! negative regulation of apoptotic process relationship: part_of GO:0043066 ! negative regulation of apoptotic process created_by: jl creation_date: 2010-08-20T03:07:53Z [Term] id: GO:0044337 name: canonical Wnt signaling pathway involved in positive regulation of apoptotic process namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of apoptotic process." [GOC:BHF, GOC:jl, GOC:mtg_apoptosis] synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of apoptosis" NARROW [] synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of apoptotic process" EXACT [] synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of apoptosis" EXACT [GOC:mah] synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of apoptotic process" EXACT [GOC:signaling] is_a: GO:0060070 ! canonical Wnt signaling pathway intersection_of: GO:0060070 ! canonical Wnt signaling pathway intersection_of: part_of GO:0043065 ! positive regulation of apoptotic process relationship: part_of GO:0043065 ! positive regulation of apoptotic process created_by: jl creation_date: 2010-08-20T03:08:24Z [Term] id: GO:0044340 name: canonical Wnt signaling pathway involved in regulation of cell proliferation namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to modulating the rate or frequency of cell proliferation." [GOC:BHF, GOC:jl] synonym: "canonical Wnt receptor signaling pathway involved in regulation of cell proliferation" EXACT [] synonym: "canonical Wnt receptor signalling pathway involved in regulation of cell proliferation" EXACT [GOC:mah] synonym: "canonical Wnt-activated signaling pathway involved in regulation of cell proliferation" EXACT [GOC:signaling] is_a: GO:0060070 ! canonical Wnt signaling pathway intersection_of: GO:0060070 ! canonical Wnt signaling pathway intersection_of: part_of GO:0008283 ! cell population proliferation relationship: part_of GO:0008283 ! cell population proliferation relationship: part_of GO:0042127 ! regulation of cell population proliferation created_by: jl creation_date: 2010-08-20T03:57:25Z [Term] id: GO:0044344 name: cellular response to fibroblast growth factor stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus." [GOC:jl, GOC:yaf] synonym: "cellular response to FGF stimulus" EXACT [] is_a: GO:0071363 ! cellular response to growth factor stimulus is_a: GO:0071495 ! cellular response to endogenous stimulus is_a: GO:0071774 ! response to fibroblast growth factor created_by: jl creation_date: 2010-08-25T02:00:51Z [Term] id: GO:0044703 name: multi-organism reproductive process namespace: biological_process def: "A biological process that directly contributes to the process of producing new individuals, involving another organism." [GOC:jl] is_a: GO:0022414 ! reproductive process is_a: GO:0051704 ! multi-organism process created_by: jl creation_date: 2012-09-19T15:56:30Z [Term] id: GO:0044782 name: cilium organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. subset: goslim_drosophila synonym: "microtubule-based flagellum organization" EXACT [] is_a: GO:0006996 ! organelle organization is_a: GO:0120036 ! plasma membrane bounded cell projection organization created_by: jl creation_date: 2013-03-27T15:09:58Z [Term] id: GO:0045184 name: establishment of protein localization namespace: biological_process def: "The directed movement of a protein to a specific location." [GOC:bf] synonym: "establishment of protein localisation" EXACT [GOC:mah] synonym: "protein positioning" EXACT [] synonym: "protein recruitment" EXACT [] is_a: GO:0008104 ! protein localization is_a: GO:0051234 ! establishment of localization [Term] id: GO:0045214 name: sarcomere organization namespace: biological_process alt_id: GO:0006938 def: "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf] synonym: "sarcomere alignment" EXACT [] synonym: "sarcomere organisation" EXACT [] is_a: GO:0031032 ! actomyosin structure organization relationship: part_of GO:0030239 ! myofibril assembly [Term] id: GO:0045595 name: regulation of cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators] is_a: GO:0050793 ! regulation of developmental process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0030154 ! cell differentiation relationship: regulates GO:0030154 ! cell differentiation [Term] id: GO:0045596 name: negative regulation of cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators] synonym: "down regulation of cell differentiation" EXACT [] synonym: "down-regulation of cell differentiation" EXACT [] synonym: "downregulation of cell differentiation" EXACT [] synonym: "inhibition of cell differentiation" NARROW [] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0030154 ! cell differentiation relationship: negatively_regulates GO:0030154 ! cell differentiation [Term] id: GO:0045597 name: positive regulation of cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators] synonym: "activation of cell differentiation" NARROW [] synonym: "stimulation of cell differentiation" NARROW [] synonym: "up regulation of cell differentiation" EXACT [] synonym: "up-regulation of cell differentiation" EXACT [] synonym: "upregulation of cell differentiation" EXACT [] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0030154 ! cell differentiation relationship: positively_regulates GO:0030154 ! cell differentiation [Term] id: GO:0045664 name: regulation of neuron differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuron differentiation." [GOC:go_curators] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0030182 ! neuron differentiation relationship: regulates GO:0030182 ! neuron differentiation [Term] id: GO:0045665 name: negative regulation of neuron differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation." [GOC:go_curators] synonym: "down regulation of neuron differentiation" EXACT [] synonym: "down-regulation of neuron differentiation" EXACT [] synonym: "downregulation of neuron differentiation" EXACT [] synonym: "inhibition of neuron differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045664 ! regulation of neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0030182 ! neuron differentiation relationship: negatively_regulates GO:0030182 ! neuron differentiation [Term] id: GO:0045666 name: positive regulation of neuron differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuron differentiation." [GOC:go_curators] synonym: "activation of neuron differentiation" NARROW [] synonym: "stimulation of neuron differentiation" NARROW [] synonym: "up regulation of neuron differentiation" EXACT [] synonym: "up-regulation of neuron differentiation" EXACT [] synonym: "upregulation of neuron differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045664 ! regulation of neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0030182 ! neuron differentiation relationship: positively_regulates GO:0030182 ! neuron differentiation [Term] id: GO:0045724 name: positive regulation of cilium assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the formation of a cilium." [GOC:cilia, GOC:go_curators] synonym: "activation of cilium assembly" NARROW [] synonym: "positive regulation of flagellum assembly" BROAD [] synonym: "positive regulation of flagellum biogenesis" RELATED [GOC:mah] synonym: "stimulation of cilium assembly" NARROW [] synonym: "up regulation of cilium assembly" EXACT [] synonym: "up-regulation of cilium assembly" EXACT [] synonym: "upregulation of cilium assembly" EXACT [] is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly is_a: GO:1902017 ! regulation of cilium assembly is_a: GO:1902117 ! positive regulation of organelle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0060271 ! cilium assembly relationship: positively_regulates GO:0060271 ! cilium assembly [Term] id: GO:0045743 name: positive regulation of fibroblast growth factor receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators] synonym: "activation of fibroblast growth factor receptor signaling pathway" NARROW [] synonym: "positive regulation of FGF receptor signaling pathway" EXACT [] synonym: "positive regulation of FGF receptor signalling pathway" EXACT [] synonym: "positive regulation of FGFR signaling pathway" EXACT [] synonym: "stimulation of fibroblast growth factor receptor signaling pathway" NARROW [] synonym: "up regulation of fibroblast growth factor receptor signaling pathway" EXACT [] synonym: "up-regulation of fibroblast growth factor receptor signaling pathway" EXACT [] synonym: "upregulation of fibroblast growth factor receptor signaling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0040036 ! regulation of fibroblast growth factor receptor signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway relationship: positively_regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway [Term] id: GO:0045773 name: positive regulation of axon extension namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of axon extension." [GOC:go_curators] synonym: "activation of axon extension" NARROW [] synonym: "stimulation of axon extension" NARROW [] synonym: "up regulation of axon extension" EXACT [] synonym: "up-regulation of axon extension" EXACT [] synonym: "upregulation of axon extension" EXACT [] is_a: GO:0030307 ! positive regulation of cell growth is_a: GO:0030516 ! regulation of axon extension is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0050772 ! positive regulation of axonogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0048675 ! axon extension relationship: positively_regulates GO:0048675 ! axon extension [Term] id: GO:0045785 name: positive regulation of cell adhesion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell adhesion." [GOC:go_curators] synonym: "activation of cell adhesion" NARROW [] synonym: "stimulation of cell adhesion" NARROW [] synonym: "up regulation of cell adhesion" EXACT [] synonym: "up-regulation of cell adhesion" EXACT [] synonym: "upregulation of cell adhesion" EXACT [] is_a: GO:0030155 ! regulation of cell adhesion is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007155 ! cell adhesion relationship: positively_regulates GO:0007155 ! cell adhesion [Term] id: GO:0045786 name: negative regulation of cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of progression through cell cycle" EXACT [] synonym: "down-regulation of progression through cell cycle" EXACT [] synonym: "downregulation of progression through cell cycle" EXACT [] synonym: "inhibition of progression through cell cycle" NARROW [] synonym: "negative regulation of cell cycle progression" EXACT [] synonym: "negative regulation of progression through cell cycle" EXACT [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007049 ! cell cycle relationship: negatively_regulates GO:0007049 ! cell cycle [Term] id: GO:0045787 name: positive regulation of cell cycle namespace: biological_process def: "Any process that activates or increases the rate or extent of progression through the cell cycle." [GOC:go_curators] synonym: "activation of progression through cell cycle" NARROW [] synonym: "positive regulation of cell cycle progression" EXACT [] synonym: "positive regulation of progression through cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through cell cycle" NARROW [] synonym: "up regulation of progression through cell cycle" EXACT [] synonym: "up-regulation of progression through cell cycle" EXACT [] synonym: "upregulation of progression through cell cycle" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007049 ! cell cycle relationship: positively_regulates GO:0007049 ! cell cycle [Term] id: GO:0045822 name: negative regulation of heart contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction." [GOC:go_curators] synonym: "down regulation of heart contraction" EXACT [] synonym: "down-regulation of heart contraction" EXACT [] synonym: "downregulation of heart contraction" EXACT [] synonym: "inhibition of heart contraction" NARROW [] synonym: "negative regulation of cardiac contraction" RELATED [] is_a: GO:0008016 ! regulation of heart contraction is_a: GO:1903523 ! negative regulation of blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0060047 ! heart contraction relationship: negatively_regulates GO:0060047 ! heart contraction [Term] id: GO:0045823 name: positive regulation of heart contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of heart contraction." [GOC:go_curators] synonym: "activation of heart contraction" NARROW [] synonym: "positive regulation of cardiac contraction" EXACT [] synonym: "stimulation of heart contraction" NARROW [] synonym: "up regulation of heart contraction" EXACT [] synonym: "up-regulation of heart contraction" EXACT [] synonym: "upregulation of heart contraction" EXACT [] is_a: GO:0008016 ! regulation of heart contraction is_a: GO:1903524 ! positive regulation of blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0060047 ! heart contraction relationship: positively_regulates GO:0060047 ! heart contraction [Term] id: GO:0045835 name: negative regulation of meiotic nuclear division namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis." [GOC:go_curators] synonym: "down regulation of meiosis" EXACT [] synonym: "down-regulation of meiosis" EXACT [] synonym: "downregulation of meiosis" EXACT [] synonym: "inhibition of meiosis" NARROW [] synonym: "negative regulation of meiosis" EXACT [] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0040020 ! regulation of meiotic nuclear division is_a: GO:0051447 ! negative regulation of meiotic cell cycle is_a: GO:0051784 ! negative regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0140013 ! meiotic nuclear division relationship: negatively_regulates GO:0140013 ! meiotic nuclear division [Term] id: GO:0045836 name: positive regulation of meiotic nuclear division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of meiosis." [GOC:go_curators] synonym: "activation of meiosis" NARROW [] synonym: "positive regulation of meiosis" EXACT [] synonym: "stimulation of meiosis" NARROW [] synonym: "up regulation of meiosis" EXACT [] synonym: "up-regulation of meiosis" EXACT [] synonym: "upregulation of meiosis" EXACT [] is_a: GO:0040020 ! regulation of meiotic nuclear division is_a: GO:0051446 ! positive regulation of meiotic cell cycle is_a: GO:0051785 ! positive regulation of nuclear division is_a: GO:0090068 ! positive regulation of cell cycle process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0140013 ! meiotic nuclear division relationship: positively_regulates GO:0140013 ! meiotic nuclear division [Term] id: GO:0045839 name: negative regulation of mitotic nuclear division namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of mitosis" EXACT [] synonym: "down-regulation of mitosis" EXACT [] synonym: "downregulation of mitosis" EXACT [] synonym: "inhibition of mitosis" NARROW [] synonym: "negative regulation of mitosis" EXACT [] is_a: GO:0007088 ! regulation of mitotic nuclear division is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0045930 ! negative regulation of mitotic cell cycle is_a: GO:0051784 ! negative regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0140014 ! mitotic nuclear division relationship: negatively_regulates GO:0140014 ! mitotic nuclear division [Term] id: GO:0045840 name: positive regulation of mitotic nuclear division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitosis." [GOC:go_curators] synonym: "activation of mitosis" NARROW [] synonym: "mitogenic activity" NARROW [] synonym: "positive regulation of mitosis" EXACT [] synonym: "stimulation of mitosis" NARROW [] synonym: "up regulation of mitosis" EXACT [] synonym: "up-regulation of mitosis" EXACT [] synonym: "upregulation of mitosis" EXACT [] is_a: GO:0007088 ! regulation of mitotic nuclear division is_a: GO:0051785 ! positive regulation of nuclear division is_a: GO:0090068 ! positive regulation of cell cycle process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0140014 ! mitotic nuclear division relationship: positively_regulates GO:0140014 ! mitotic nuclear division [Term] id: GO:0045859 name: regulation of protein kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein kinase activity." [GOC:go_curators] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0043549 ! regulation of kinase activity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0004672 ! protein kinase activity relationship: regulates GO:0004672 ! protein kinase activity [Term] id: GO:0045860 name: positive regulation of protein kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators] synonym: "stimulation of protein kinase activity" NARROW [] synonym: "up regulation of protein kinase activity" EXACT [] synonym: "up-regulation of protein kinase activity" EXACT [] synonym: "upregulation of protein kinase activity" EXACT [] is_a: GO:0001934 ! positive regulation of protein phosphorylation is_a: GO:0033674 ! positive regulation of kinase activity is_a: GO:0045859 ! regulation of protein kinase activity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0004672 ! protein kinase activity relationship: positively_regulates GO:0004672 ! protein kinase activity [Term] id: GO:0045861 name: negative regulation of proteolysis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] synonym: "down regulation of proteolysis" EXACT [] synonym: "down-regulation of proteolysis" EXACT [] synonym: "downregulation of proteolysis" EXACT [] synonym: "inhibition of proteolysis" NARROW [] synonym: "negative regulation of peptidolysis" EXACT [] is_a: GO:0030162 ! regulation of proteolysis is_a: GO:0032269 ! negative regulation of cellular protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006508 ! proteolysis relationship: negatively_regulates GO:0006508 ! proteolysis [Term] id: GO:0045862 name: positive regulation of proteolysis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] synonym: "activation of proteolysis" NARROW [] synonym: "positive regulation of peptidolysis" EXACT [] synonym: "stimulation of proteolysis" NARROW [] synonym: "up regulation of proteolysis" EXACT [] synonym: "up-regulation of proteolysis" EXACT [] synonym: "upregulation of proteolysis" EXACT [] is_a: GO:0030162 ! regulation of proteolysis is_a: GO:0032270 ! positive regulation of cellular protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006508 ! proteolysis relationship: positively_regulates GO:0006508 ! proteolysis [Term] id: GO:0045892 name: negative regulation of transcription, DNA-templated namespace: biological_process alt_id: GO:0016481 alt_id: GO:0032582 alt_id: GO:0061021 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] synonym: "down regulation of gene-specific transcription" RELATED [] synonym: "down regulation of transcription, DNA-dependent" EXACT [] synonym: "down-regulation of gene-specific transcription" RELATED [] synonym: "down-regulation of transcription, DNA-dependent" EXACT [] synonym: "downregulation of gene-specific transcription" RELATED [] synonym: "downregulation of transcription, DNA-dependent" EXACT [] synonym: "inhibition of gene-specific transcription" RELATED [] synonym: "inhibition of transcription, DNA-dependent" NARROW [] synonym: "negative regulation of cellular transcription, DNA-dependent" EXACT [] synonym: "negative regulation of gene-specific transcription" RELATED [] synonym: "negative regulation of transcription, DNA-dependent" EXACT [GOC:txnOH] synonym: "transcription repressor activity" RELATED [] is_a: GO:0006355 ! regulation of transcription, DNA-templated is_a: GO:1903507 ! negative regulation of nucleic acid-templated transcription is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006351 ! transcription, DNA-templated relationship: negatively_regulates GO:0006351 ! transcription, DNA-templated [Term] id: GO:0045893 name: positive regulation of transcription, DNA-templated namespace: biological_process alt_id: GO:0043193 alt_id: GO:0045941 alt_id: GO:0061020 def: "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] synonym: "activation of gene-specific transcription" RELATED [] synonym: "activation of transcription, DNA-dependent" NARROW [] synonym: "positive regulation of cellular transcription, DNA-dependent" EXACT [] synonym: "positive regulation of gene-specific transcription" RELATED [] synonym: "positive regulation of transcription, DNA-dependent" EXACT [GOC:txnOH] synonym: "stimulation of gene-specific transcription" NARROW [] synonym: "stimulation of transcription, DNA-dependent" NARROW [] synonym: "transcription activator activity" RELATED [] synonym: "up regulation of gene-specific transcription" RELATED [] synonym: "up regulation of transcription, DNA-dependent" EXACT [] synonym: "up-regulation of gene-specific transcription" RELATED [] synonym: "up-regulation of transcription, DNA-dependent" EXACT [] synonym: "upregulation of gene-specific transcription" RELATED [] synonym: "upregulation of transcription, DNA-dependent" EXACT [] is_a: GO:0006355 ! regulation of transcription, DNA-templated is_a: GO:1903508 ! positive regulation of nucleic acid-templated transcription intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006351 ! transcription, DNA-templated relationship: positively_regulates GO:0006351 ! transcription, DNA-templated [Term] id: GO:0045926 name: negative regulation of growth namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators] synonym: "down regulation of growth" EXACT [] synonym: "down-regulation of growth" EXACT [] synonym: "downregulation of growth" EXACT [] synonym: "inhibition of growth" NARROW [] is_a: GO:0040008 ! regulation of growth is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0040007 ! growth relationship: negatively_regulates GO:0040007 ! growth [Term] id: GO:0045927 name: positive regulation of growth namespace: biological_process def: "Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators] synonym: "activation of growth" NARROW [] synonym: "stimulation of growth" NARROW [] synonym: "up regulation of growth" EXACT [] synonym: "up-regulation of growth" EXACT [] synonym: "upregulation of growth" EXACT [] is_a: GO:0040008 ! regulation of growth is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0040007 ! growth relationship: positively_regulates GO:0040007 ! growth [Term] id: GO:0045930 name: negative regulation of mitotic cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of progression through mitotic cell cycle" EXACT [] synonym: "down-regulation of progression through mitotic cell cycle" EXACT [] synonym: "downregulation of progression through mitotic cell cycle" EXACT [] synonym: "inhibition of progression through mitotic cell cycle" NARROW [] synonym: "negative regulation of mitotic cell cycle progression" EXACT [] synonym: "negative regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0045786 ! negative regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0000278 ! mitotic cell cycle relationship: negatively_regulates GO:0000278 ! mitotic cell cycle [Term] id: GO:0045931 name: positive regulation of mitotic cell cycle namespace: biological_process def: "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of progression through mitotic cell cycle" NARROW [] synonym: "positive regulation of mitotic cell cycle progression" EXACT [] synonym: "positive regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through mitotic cell cycle" NARROW [] synonym: "up regulation of progression through mitotic cell cycle" EXACT [] synonym: "up-regulation of progression through mitotic cell cycle" EXACT [] synonym: "upregulation of progression through mitotic cell cycle" EXACT [] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0045787 ! positive regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0000278 ! mitotic cell cycle relationship: positively_regulates GO:0000278 ! mitotic cell cycle [Term] id: GO:0045934 name: negative regulation of nucleobase-containing compound metabolic process namespace: biological_process def: "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] synonym: "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006139 ! nucleobase-containing compound metabolic process relationship: negatively_regulates GO:0006139 ! nucleobase-containing compound metabolic process [Term] id: GO:0045935 name: positive regulation of nucleobase-containing compound metabolic process namespace: biological_process def: "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] synonym: "activation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] synonym: "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] synonym: "up regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "upregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006139 ! nucleobase-containing compound metabolic process relationship: positively_regulates GO:0006139 ! nucleobase-containing compound metabolic process [Term] id: GO:0045936 name: negative regulation of phosphate metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] synonym: "down regulation of phosphate metabolic process" EXACT [] synonym: "down-regulation of phosphate metabolic process" EXACT [] synonym: "downregulation of phosphate metabolic process" EXACT [] synonym: "inhibition of phosphate metabolic process" NARROW [] synonym: "negative regulation of phosphate metabolism" EXACT [] is_a: GO:0010563 ! negative regulation of phosphorus metabolic process is_a: GO:0019220 ! regulation of phosphate metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006796 ! phosphate-containing compound metabolic process relationship: negatively_regulates GO:0006796 ! phosphate-containing compound metabolic process [Term] id: GO:0045937 name: positive regulation of phosphate metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] synonym: "activation of phosphate metabolic process" NARROW [] synonym: "positive regulation of phosphate metabolism" EXACT [] synonym: "stimulation of phosphate metabolic process" NARROW [] synonym: "up regulation of phosphate metabolic process" EXACT [] synonym: "up-regulation of phosphate metabolic process" EXACT [] synonym: "upregulation of phosphate metabolic process" EXACT [] is_a: GO:0010562 ! positive regulation of phosphorus metabolic process is_a: GO:0019220 ! regulation of phosphate metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006796 ! phosphate-containing compound metabolic process relationship: positively_regulates GO:0006796 ! phosphate-containing compound metabolic process [Term] id: GO:0045944 name: positive regulation of transcription by RNA polymerase II namespace: biological_process alt_id: GO:0010552 alt_id: GO:0045817 def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] synonym: "activation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "activation of transcription from RNA polymerase II promoter" EXACT [] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [] synonym: "positive regulation of global transcription from Pol II promoter" RELATED [] synonym: "positive regulation of transcription from Pol II promoter" EXACT [] synonym: "positive regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "positive regulation of transcription from RNA polymerase II promoter, global" RELATED [] synonym: "stimulation of global transcription from RNA polymerase II promoter" NARROW [] synonym: "stimulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "up regulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "up regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "up-regulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "up-regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "upregulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "upregulation of transcription from RNA polymerase II promoter" EXACT [] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0045893 ! positive regulation of transcription, DNA-templated intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006366 ! transcription by RNA polymerase II relationship: positively_regulates GO:0006366 ! transcription by RNA polymerase II [Term] id: GO:0045992 name: negative regulation of embryonic development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development." [GOC:go_curators] synonym: "down regulation of embryonic development" EXACT [] synonym: "down-regulation of embryonic development" EXACT [] synonym: "downregulation of embryonic development" EXACT [] synonym: "inhibition of embryonic development" NARROW [] is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009790 ! embryo development relationship: negatively_regulates GO:0009790 ! embryo development [Term] id: GO:0045995 name: regulation of embryonic development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of embryonic development." [GOC:go_curators] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009790 ! embryo development relationship: regulates GO:0009790 ! embryo development [Term] id: GO:0046328 name: regulation of JNK cascade namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] synonym: "regulation of SAPK cascade" BROAD [] is_a: GO:0032872 ! regulation of stress-activated MAPK cascade intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007254 ! JNK cascade relationship: regulates GO:0007254 ! JNK cascade [Term] id: GO:0046329 name: negative regulation of JNK cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] synonym: "down regulation of JNK cascade" EXACT [] synonym: "down-regulation of JNK cascade" EXACT [] synonym: "downregulation of JNK cascade" EXACT [] synonym: "inhibition of JNK cascade" NARROW [] is_a: GO:0032873 ! negative regulation of stress-activated MAPK cascade is_a: GO:0046328 ! regulation of JNK cascade intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007254 ! JNK cascade relationship: negatively_regulates GO:0007254 ! JNK cascade [Term] id: GO:0046330 name: positive regulation of JNK cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] synonym: "activation of JNK cascade" NARROW [] synonym: "stimulation of JNK cascade" NARROW [] synonym: "up regulation of JNK cascade" EXACT [] synonym: "up-regulation of JNK cascade" EXACT [] synonym: "upregulation of JNK cascade" EXACT [] is_a: GO:0032874 ! positive regulation of stress-activated MAPK cascade is_a: GO:0046328 ! regulation of JNK cascade intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007254 ! JNK cascade relationship: positively_regulates GO:0007254 ! JNK cascade [Term] id: GO:0046483 name: heterocycle metabolic process namespace: biological_process def: "The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198506732] subset: goslim_pir synonym: "heterocycle metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0046620 name: regulation of organ growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0035265 ! organ growth relationship: regulates GO:0035265 ! organ growth [Term] id: GO:0046621 name: negative regulation of organ growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] is_a: GO:0046620 ! regulation of organ growth is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0035265 ! organ growth relationship: negatively_regulates GO:0035265 ! organ growth [Term] id: GO:0046622 name: positive regulation of organ growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] is_a: GO:0046620 ! regulation of organ growth is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0035265 ! organ growth relationship: positively_regulates GO:0035265 ! organ growth [Term] id: GO:0046626 name: regulation of insulin receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of insulin receptor signaling." [GOC:bf] synonym: "regulation of insulin receptor signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0008286 ! insulin receptor signaling pathway relationship: regulates GO:0008286 ! insulin receptor signaling pathway [Term] id: GO:0046627 name: negative regulation of insulin receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf] synonym: "down regulation of insulin receptor signaling pathway" EXACT [] synonym: "down-regulation of insulin receptor signaling pathway" EXACT [] synonym: "downregulation of insulin receptor signaling pathway" EXACT [] synonym: "inhibition of insulin receptor signaling pathway" NARROW [] synonym: "negative regulation of insulin receptor signalling pathway" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0046626 ! regulation of insulin receptor signaling pathway is_a: GO:1900077 ! negative regulation of cellular response to insulin stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0008286 ! insulin receptor signaling pathway relationship: negatively_regulates GO:0008286 ! insulin receptor signaling pathway [Term] id: GO:0046628 name: positive regulation of insulin receptor signaling pathway namespace: biological_process def: "Any process that increases the frequency, rate or extent of insulin receptor signaling." [GOC:bf] synonym: "activation of insulin receptor signaling pathway" NARROW [] synonym: "positive regulation of insulin receptor signalling pathway" EXACT [] synonym: "stimulation of insulin receptor signaling pathway" NARROW [] synonym: "up regulation of insulin receptor signaling pathway" EXACT [] synonym: "up-regulation of insulin receptor signaling pathway" EXACT [] synonym: "upregulation of insulin receptor signaling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0046626 ! regulation of insulin receptor signaling pathway is_a: GO:1900078 ! positive regulation of cellular response to insulin stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0008286 ! insulin receptor signaling pathway relationship: positively_regulates GO:0008286 ! insulin receptor signaling pathway [Term] id: GO:0046907 name: intracellular transport namespace: biological_process alt_id: GO:1902582 def: "The directed movement of substances within a cell." [GOC:ai] synonym: "single organism intracellular transport" RELATED [GOC:TermGenie] synonym: "single-organism intracellular transport" RELATED [] is_a: GO:0006810 ! transport is_a: GO:0051641 ! cellular localization is_a: GO:0051649 ! establishment of localization in cell intersection_of: GO:0006810 ! transport intersection_of: occurs_in GO:0005622 ! intracellular anatomical structure relationship: occurs_in GO:0005622 ! intracellular anatomical structure created_by: jl creation_date: 2013-12-18T14:04:50Z [Term] id: GO:0048193 name: Golgi vesicle transport namespace: biological_process def: "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233] subset: goslim_yeast synonym: "Golgi-derived vesicle transport" RELATED [] is_a: GO:0016192 ! vesicle-mediated transport [Term] id: GO:0048199 name: vesicle targeting, to, from or within Golgi namespace: biological_process def: "The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "dictyosome vesicle targeting" NARROW [] synonym: "Golgi vesicle targeting" EXACT [] synonym: "vesicle targeting, to, from or within dictyosome" NARROW [] is_a: GO:0006903 ! vesicle targeting relationship: part_of GO:0048193 ! Golgi vesicle transport [Term] id: GO:0048209 name: regulation of vesicle targeting, to, from or within Golgi namespace: biological_process def: "Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "regulation of Golgi vesicle targeting" EXACT [] is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0048199 ! vesicle targeting, to, from or within Golgi relationship: regulates GO:0048199 ! vesicle targeting, to, from or within Golgi [Term] id: GO:0048232 name: male gamete generation namespace: biological_process def: "Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction." [GOC:dph, GOC:jid] is_a: GO:0007276 ! gamete generation [Term] id: GO:0048265 name: response to pain namespace: biological_process alt_id: GO:0048267 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli." [GOC:jid, PMID:10203867, PMID:12723742, PMID:12843304, Wikipedia:Pain] synonym: "physiological response to pain" EXACT [] is_a: GO:0033555 ! multicellular organismal response to stress [Term] id: GO:0048266 name: behavioral response to pain namespace: biological_process def: "Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli." [GOC:jid] synonym: "behavioural response to pain" EXACT [] is_a: GO:0007610 ! behavior relationship: part_of GO:0048265 ! response to pain [Term] id: GO:0048285 name: organelle fission namespace: biological_process def: "The creation of two or more organelles by division of one organelle." [GOC:jid] subset: goslim_pir subset: goslim_yeast is_a: GO:0006996 ! organelle organization [Term] id: GO:0048332 name: mesoderm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the mesoderm are generated and organized." [GOC:go_curators] is_a: GO:0048729 ! tissue morphogenesis relationship: part_of GO:0007498 ! mesoderm development [Term] id: GO:0048468 name: cell development namespace: biological_process def: "The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:go_curators] subset: goslim_candida synonym: "terminal differentiation" RELATED [GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0030154 ! cell differentiation [Term] id: GO:0048513 name: animal organ development namespace: biological_process def: "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid] synonym: "development of an organ" EXACT [] synonym: "organogenesis" EXACT [] xref: Wikipedia:Organogenesis is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048731 ! system development [Term] id: GO:0048518 name: positive regulation of biological process namespace: biological_process alt_id: GO:0043119 def: "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] subset: gocheck_do_not_annotate synonym: "activation of biological process" NARROW [] synonym: "positive regulation of physiological process" EXACT [] synonym: "stimulation of biological process" NARROW [] synonym: "up regulation of biological process" EXACT [] synonym: "up-regulation of biological process" EXACT [] synonym: "upregulation of biological process" EXACT [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0008150 ! biological_process relationship: positively_regulates GO:0008150 ! biological_process [Term] id: GO:0048519 name: negative regulation of biological process namespace: biological_process alt_id: GO:0043118 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] subset: gocheck_do_not_annotate synonym: "down regulation of biological process" EXACT [] synonym: "down-regulation of biological process" EXACT [] synonym: "downregulation of biological process" EXACT [] synonym: "inhibition of biological process" NARROW [] synonym: "negative regulation of physiological process" EXACT [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0008150 ! biological_process relationship: negatively_regulates GO:0008150 ! biological_process [Term] id: GO:0048520 name: positive regulation of behavior namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:jid, GOC:pr] synonym: "activation of behavior" NARROW [] synonym: "stimulation of behavior" NARROW [] synonym: "up regulation of behavior" EXACT [] synonym: "up-regulation of behavior" EXACT [] synonym: "upregulation of behavior" EXACT [] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0050795 ! regulation of behavior intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007610 ! behavior relationship: positively_regulates GO:0007610 ! behavior [Term] id: GO:0048521 name: negative regulation of behavior namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:jid, GOC:pr] synonym: "down regulation of behavior" EXACT [] synonym: "down-regulation of behavior" EXACT [] synonym: "downregulation of behavior" EXACT [] synonym: "inhibition of behavior" NARROW [] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0050795 ! regulation of behavior intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007610 ! behavior relationship: negatively_regulates GO:0007610 ! behavior [Term] id: GO:0048522 name: positive regulation of cellular process namespace: biological_process alt_id: GO:0051242 def: "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] synonym: "activation of cellular process" NARROW [] synonym: "positive regulation of cellular physiological process" EXACT [] synonym: "stimulation of cellular process" NARROW [] synonym: "up regulation of cellular process" EXACT [] synonym: "up-regulation of cellular process" EXACT [] synonym: "upregulation of cellular process" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009987 ! cellular process relationship: positively_regulates GO:0009987 ! cellular process [Term] id: GO:0048523 name: negative regulation of cellular process namespace: biological_process alt_id: GO:0051243 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] synonym: "down regulation of cellular process" EXACT [] synonym: "down-regulation of cellular process" EXACT [] synonym: "downregulation of cellular process" EXACT [] synonym: "inhibition of cellular process" NARROW [] synonym: "negative regulation of cellular physiological process" EXACT [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009987 ! cellular process relationship: negatively_regulates GO:0009987 ! cellular process [Term] id: GO:0048562 name: embryonic organ morphogenesis namespace: biological_process def: "Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid] is_a: GO:0009887 ! animal organ morphogenesis is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0048568 ! embryonic organ development [Term] id: GO:0048568 name: embryonic organ development namespace: biological_process def: "Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid] synonym: "embryonic organogenesis" EXACT [] is_a: GO:0048513 ! animal organ development relationship: part_of GO:0009790 ! embryo development [Term] id: GO:0048570 name: notochord morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column." [GOC:jid] is_a: GO:0048562 ! embryonic organ morphogenesis relationship: part_of GO:0030903 ! notochord development [Term] id: GO:0048583 name: regulation of response to stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0050896 ! response to stimulus relationship: regulates GO:0050896 ! response to stimulus [Term] id: GO:0048584 name: positive regulation of response to stimulus namespace: biological_process def: "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "activation of response to stimulus" NARROW [] synonym: "stimulation of response to stimulus" NARROW [] synonym: "up regulation of response to stimulus" EXACT [] synonym: "up-regulation of response to stimulus" EXACT [] synonym: "upregulation of response to stimulus" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0050896 ! response to stimulus relationship: positively_regulates GO:0050896 ! response to stimulus [Term] id: GO:0048585 name: negative regulation of response to stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "down regulation of response to stimulus" EXACT [] synonym: "down-regulation of response to stimulus" EXACT [] synonym: "downregulation of response to stimulus" EXACT [] synonym: "inhibition of response to stimulus" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0050896 ! response to stimulus relationship: negatively_regulates GO:0050896 ! response to stimulus [Term] id: GO:0048588 name: developmental cell growth namespace: biological_process def: "The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another." [GOC:go_curators, GOC:isa_complete] synonym: "developmental growth of a unicellular organism" EXACT [] is_a: GO:0016049 ! cell growth is_a: GO:0048589 ! developmental growth relationship: part_of GO:0048468 ! cell development [Term] id: GO:0048589 name: developmental growth namespace: biological_process def: "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators] is_a: GO:0032502 ! developmental process is_a: GO:0040007 ! growth [Term] id: GO:0048598 name: embryonic morphogenesis namespace: biological_process alt_id: GO:0048828 def: "The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jid, GOC:mtg_sensu] synonym: "embryonic anatomical structure morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0009790 ! embryo development [Term] id: GO:0048608 name: reproductive structure development namespace: biological_process def: "The reproductive developmental process whose specific outcome is the progression of structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures." [GOC:dph, GOC:isa_complete, GOC:jid] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0061458 ! reproductive system development [Term] id: GO:0048609 name: multicellular organismal reproductive process namespace: biological_process def: "The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs." [GOC:dph, GOC:jid, GOC:tb] synonym: "organismal reproductive process" BROAD [] synonym: "reproductive process in a multicellular organism" EXACT [] is_a: GO:0022414 ! reproductive process relationship: part_of GO:0032504 ! multicellular organism reproduction [Term] id: GO:0048638 name: regulation of developmental growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of developmental growth." [GOC:go_curators] is_a: GO:0040008 ! regulation of growth is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0048589 ! developmental growth relationship: regulates GO:0048589 ! developmental growth [Term] id: GO:0048639 name: positive regulation of developmental growth namespace: biological_process def: "Any process that activates, maintains or increases the rate of developmental growth." [GOC:go_curators] synonym: "activation of developmental growth" NARROW [] synonym: "stimulation of developmental growth" NARROW [] synonym: "up regulation of developmental growth" EXACT [] synonym: "up-regulation of developmental growth" EXACT [] synonym: "upregulation of developmental growth" EXACT [] is_a: GO:0045927 ! positive regulation of growth is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0048589 ! developmental growth relationship: positively_regulates GO:0048589 ! developmental growth [Term] id: GO:0048640 name: negative regulation of developmental growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth." [GOC:go_curators] synonym: "down regulation of developmental growth" EXACT [] synonym: "down-regulation of developmental growth" EXACT [] synonym: "downregulation of developmental growth" EXACT [] synonym: "inhibition of developmental growth" NARROW [] is_a: GO:0045926 ! negative regulation of growth is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0048589 ! developmental growth relationship: negatively_regulates GO:0048589 ! developmental growth [Term] id: GO:0048646 name: anatomical structure formation involved in morphogenesis namespace: biological_process def: "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb] comment: Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense. subset: goslim_chembl subset: goslim_generic synonym: "formation of an anatomical structure involved in morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0032502 ! developmental process relationship: part_of GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0048666 name: neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0030182 ! neuron differentiation [Term] id: GO:0048667 name: cell morphogenesis involved in neuron differentiation namespace: biological_process def: "The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron." [GOC:dph, GOC:tb] synonym: "neuron morphogenesis involved in differentiation" EXACT [GOC:dph, GOC:tb] is_a: GO:0000904 ! cell morphogenesis involved in differentiation intersection_of: GO:0000902 ! cell morphogenesis intersection_of: part_of GO:0030182 ! neuron differentiation relationship: part_of GO:0048666 ! neuron development [Term] id: GO:0048675 name: axon extension namespace: biological_process alt_id: GO:0048676 def: "Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl] synonym: "axon extension involved in development" EXACT [] is_a: GO:1990138 ! neuron projection extension relationship: part_of GO:0007409 ! axonogenesis [Term] id: GO:0048677 name: axon extension involved in regeneration namespace: biological_process def: "Long distance growth of a single axon process involved in regeneration of the neuron." [GOC:jid] is_a: GO:0048675 ! axon extension is_a: GO:0048682 ! sprouting of injured axon intersection_of: GO:0048675 ! axon extension intersection_of: part_of GO:0031099 ! regeneration [Term] id: GO:0048678 name: response to axon injury namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0009611 ! response to wounding [Term] id: GO:0048679 name: regulation of axon regeneration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of axon regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0070570 ! regulation of neuron projection regeneration is_a: GO:1903034 ! regulation of response to wounding intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0031103 ! axon regeneration relationship: regulates GO:0031103 ! axon regeneration [Term] id: GO:0048680 name: positive regulation of axon regeneration namespace: biological_process def: "Any process that activates, maintains or increases the rate of axon regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "activation of axon regeneration" NARROW [] synonym: "stimulation of axon regeneration" NARROW [] synonym: "up regulation of axon regeneration" EXACT [] synonym: "up-regulation of axon regeneration" EXACT [] synonym: "upregulation of axon regeneration" EXACT [] is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0048679 ! regulation of axon regeneration is_a: GO:0070572 ! positive regulation of neuron projection regeneration is_a: GO:1903036 ! positive regulation of response to wounding intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0031103 ! axon regeneration relationship: positively_regulates GO:0031103 ! axon regeneration [Term] id: GO:0048681 name: negative regulation of axon regeneration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "down regulation of axon regeneration" EXACT [] synonym: "down-regulation of axon regeneration" EXACT [] synonym: "downregulation of axon regeneration" EXACT [] synonym: "inhibition of axon regeneration" NARROW [] is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0048679 ! regulation of axon regeneration is_a: GO:0070571 ! negative regulation of neuron projection regeneration is_a: GO:1903035 ! negative regulation of response to wounding intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0031103 ! axon regeneration relationship: negatively_regulates GO:0031103 ! axon regeneration [Term] id: GO:0048682 name: sprouting of injured axon namespace: biological_process def: "The process involved in sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0048588 ! developmental cell growth is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0031103 ! axon regeneration [Term] id: GO:0048686 name: regulation of sprouting of injured axon namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0061387 ! regulation of extent of cell growth intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0048682 ! sprouting of injured axon relationship: regulates GO:0048682 ! sprouting of injured axon [Term] id: GO:0048687 name: positive regulation of sprouting of injured axon namespace: biological_process def: "Any process that activates, maintains or increases the rate of sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "activation of sprouting of injured axon" NARROW [] synonym: "stimulation of sprouting of injured axon" NARROW [] synonym: "up regulation of sprouting of injured axon" EXACT [] synonym: "up-regulation of sprouting of injured axon" EXACT [] synonym: "upregulation of sprouting of injured axon" EXACT [] is_a: GO:0030307 ! positive regulation of cell growth is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0048680 ! positive regulation of axon regeneration is_a: GO:0048686 ! regulation of sprouting of injured axon intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0048682 ! sprouting of injured axon relationship: positively_regulates GO:0048682 ! sprouting of injured axon [Term] id: GO:0048688 name: negative regulation of sprouting of injured axon namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "down regulation of sprouting of injured axon" EXACT [] synonym: "down-regulation of sprouting of injured axon" EXACT [] synonym: "downregulation of sprouting of injured axon" EXACT [] synonym: "inhibition of sprouting of injured axon" NARROW [] is_a: GO:0030308 ! negative regulation of cell growth is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0048681 ! negative regulation of axon regeneration is_a: GO:0048686 ! regulation of sprouting of injured axon intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0048682 ! sprouting of injured axon relationship: negatively_regulates GO:0048682 ! sprouting of injured axon [Term] id: GO:0048690 name: regulation of axon extension involved in regeneration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of axon extension involved in regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0030516 ! regulation of axon extension is_a: GO:0048686 ! regulation of sprouting of injured axon intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0048677 ! axon extension involved in regeneration relationship: regulates GO:0048677 ! axon extension involved in regeneration [Term] id: GO:0048691 name: positive regulation of axon extension involved in regeneration namespace: biological_process def: "Any process that activates, maintains or increases the rate of axon extension involved in regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "activation of axon extension involved in regeneration" NARROW [] synonym: "stimulation of axon extension involved in regeneration" NARROW [] synonym: "up regulation of axon extension involved in regeneration" EXACT [] synonym: "up-regulation of axon extension involved in regeneration" EXACT [] synonym: "upregulation of axon extension involved in regeneration" EXACT [] is_a: GO:0045773 ! positive regulation of axon extension is_a: GO:0048687 ! positive regulation of sprouting of injured axon is_a: GO:0048690 ! regulation of axon extension involved in regeneration intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0048677 ! axon extension involved in regeneration relationship: positively_regulates GO:0048677 ! axon extension involved in regeneration [Term] id: GO:0048692 name: negative regulation of axon extension involved in regeneration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "down regulation of axon extension involved in regeneration" EXACT [] synonym: "down-regulation of axon extension involved in regeneration" EXACT [] synonym: "downregulation of axon extension involved in regeneration" EXACT [] synonym: "inhibition of axon extension involved in regeneration" NARROW [] is_a: GO:0030517 ! negative regulation of axon extension is_a: GO:0048688 ! negative regulation of sprouting of injured axon is_a: GO:0048690 ! regulation of axon extension involved in regeneration intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0048677 ! axon extension involved in regeneration relationship: negatively_regulates GO:0048677 ! axon extension involved in regeneration [Term] id: GO:0048699 name: generation of neurons namespace: biological_process def: "The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." [GOC:nln] synonym: "neuron generation" EXACT [] is_a: GO:0022008 ! neurogenesis [Term] id: GO:0048729 name: tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a tissue are generated and organized." [GOC:dph, GOC:jid] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0009888 ! tissue development [Term] id: GO:0048731 name: system development namespace: biological_process def: "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid] subset: goslim_mouse is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0048812 name: neuron projection morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] synonym: "neurite biosynthesis" NARROW [] synonym: "neurite formation" NARROW [] synonym: "neurite growth" NARROW [] synonym: "neurite morphogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0120039 ! plasma membrane bounded cell projection morphogenesis relationship: part_of GO:0031175 ! neuron projection development [Term] id: GO:0048841 name: regulation of axon extension involved in axon guidance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol] is_a: GO:0030516 ! regulation of axon extension intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0048846 ! axon extension involved in axon guidance relationship: regulates GO:0048846 ! axon extension involved in axon guidance [Term] id: GO:0048842 name: positive regulation of axon extension involved in axon guidance namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol] synonym: "activation of axon extension involved in axon guidance" NARROW [] synonym: "stimulation of axon extension involved in axon guidance" NARROW [] synonym: "up regulation of axon extension involved in axon guidance" EXACT [] synonym: "up-regulation of axon extension involved in axon guidance" EXACT [] synonym: "upregulation of axon extension involved in axon guidance" EXACT [] is_a: GO:0045773 ! positive regulation of axon extension is_a: GO:0048841 ! regulation of axon extension involved in axon guidance is_a: GO:0050921 ! positive regulation of chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0048846 ! axon extension involved in axon guidance relationship: positively_regulates GO:0048846 ! axon extension involved in axon guidance [Term] id: GO:0048843 name: negative regulation of axon extension involved in axon guidance namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol] synonym: "down regulation of axon extension involved in axon guidance" EXACT [] synonym: "down-regulation of axon extension involved in axon guidance" EXACT [] synonym: "downregulation of axon extension involved in axon guidance" EXACT [] synonym: "inhibition of axon extension involved in axon guidance" NARROW [] is_a: GO:0030517 ! negative regulation of axon extension is_a: GO:0048841 ! regulation of axon extension involved in axon guidance is_a: GO:0050922 ! negative regulation of chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0048846 ! axon extension involved in axon guidance relationship: negatively_regulates GO:0048846 ! axon extension involved in axon guidance [Term] id: GO:0048846 name: axon extension involved in axon guidance namespace: biological_process def: "The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues." [GOC:ef, GOC:jid] is_a: GO:0048675 ! axon extension is_a: GO:1902284 ! neuron projection extension involved in neuron projection guidance intersection_of: GO:0048675 ! axon extension intersection_of: part_of GO:0007411 ! axon guidance relationship: part_of GO:0007411 ! axon guidance [Term] id: GO:0048856 name: anatomical structure development namespace: biological_process def: "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021] subset: goslim_chembl subset: goslim_generic subset: goslim_plant synonym: "development of an anatomical structure" EXACT [] is_a: GO:0032502 ! developmental process [Term] id: GO:0048858 name: cell projection morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a cell projection are generated and organized." [GO_REF:0000021] is_a: GO:0030030 ! cell projection organization is_a: GO:0032990 ! cell part morphogenesis relationship: part_of GO:0000902 ! cell morphogenesis [Term] id: GO:0048869 name: cellular developmental process namespace: biological_process def: "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete] is_a: GO:0009987 ! cellular process is_a: GO:0032502 ! developmental process [Term] id: GO:0048870 name: cell motility namespace: biological_process def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic synonym: "cell locomotion" EXACT [] synonym: "cell movement" RELATED [] synonym: "movement of a cell" EXACT [] is_a: GO:0006928 ! movement of cell or subcellular component is_a: GO:0040011 ! locomotion relationship: part_of GO:0051674 ! localization of cell [Term] id: GO:0050767 name: regulation of neurogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." [GOC:ai] is_a: GO:0051960 ! regulation of nervous system development is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0022008 ! neurogenesis relationship: part_of GO:0048699 ! generation of neurons relationship: regulates GO:0022008 ! neurogenesis [Term] id: GO:0050768 name: negative regulation of neurogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system." [GOC:ai] synonym: "down regulation of neurogenesis" EXACT [] synonym: "down-regulation of neurogenesis" EXACT [] synonym: "downregulation of neurogenesis" EXACT [] synonym: "inhibition of neurogenesis" NARROW [] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0050767 ! regulation of neurogenesis is_a: GO:0051961 ! negative regulation of nervous system development intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0022008 ! neurogenesis relationship: negatively_regulates GO:0022008 ! neurogenesis [Term] id: GO:0050769 name: positive regulation of neurogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system." [GOC:ai] synonym: "activation of neurogenesis" NARROW [] synonym: "stimulation of neurogenesis" NARROW [] synonym: "up regulation of neurogenesis" EXACT [] synonym: "up-regulation of neurogenesis" EXACT [] synonym: "upregulation of neurogenesis" EXACT [] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0050767 ! regulation of neurogenesis is_a: GO:0051962 ! positive regulation of nervous system development intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0022008 ! neurogenesis relationship: positively_regulates GO:0022008 ! neurogenesis [Term] id: GO:0050770 name: regulation of axonogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron." [GOC:ai] is_a: GO:0010975 ! regulation of neuron projection development is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007409 ! axonogenesis relationship: regulates GO:0007409 ! axonogenesis [Term] id: GO:0050771 name: negative regulation of axonogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis." [GOC:ai] synonym: "down regulation of axonogenesis" EXACT [] synonym: "down-regulation of axonogenesis" EXACT [] synonym: "downregulation of axonogenesis" EXACT [] synonym: "inhibition of axonogenesis" NARROW [] is_a: GO:0010977 ! negative regulation of neuron projection development is_a: GO:0050768 ! negative regulation of neurogenesis is_a: GO:0050770 ! regulation of axonogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007409 ! axonogenesis relationship: negatively_regulates GO:0007409 ! axonogenesis [Term] id: GO:0050772 name: positive regulation of axonogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of axonogenesis." [GOC:ai] synonym: "activation of axonogenesis" NARROW [] synonym: "stimulation of axonogenesis" NARROW [] synonym: "up regulation of axonogenesis" EXACT [] synonym: "up-regulation of axonogenesis" EXACT [] synonym: "upregulation of axonogenesis" EXACT [] is_a: GO:0031346 ! positive regulation of cell projection organization is_a: GO:0050769 ! positive regulation of neurogenesis is_a: GO:0050770 ! regulation of axonogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007409 ! axonogenesis relationship: positively_regulates GO:0007409 ! axonogenesis [Term] id: GO:0050789 name: regulation of biological process namespace: biological_process alt_id: GO:0050791 def: "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators] subset: gocheck_do_not_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_pir synonym: "regulation of physiological process" EXACT [] is_a: GO:0065007 ! biological regulation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0008150 ! biological_process relationship: regulates GO:0008150 ! biological_process [Term] id: GO:0050790 name: regulation of catalytic activity namespace: biological_process alt_id: GO:0048552 def: "Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw] subset: goslim_chembl synonym: "regulation of enzyme activity" EXACT [] synonym: "regulation of metalloenzyme activity" NARROW [] is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0003824 ! catalytic activity relationship: regulates GO:0003824 ! catalytic activity [Term] id: GO:0050793 name: regulation of developmental process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0032502 ! developmental process relationship: regulates GO:0032502 ! developmental process [Term] id: GO:0050794 name: regulation of cellular process namespace: biological_process alt_id: GO:0051244 def: "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators] synonym: "regulation of cellular physiological process" EXACT [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009987 ! cellular process relationship: regulates GO:0009987 ! cellular process [Term] id: GO:0050795 name: regulation of behavior namespace: biological_process def: "Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:go_curators, GOC:pr] synonym: "regulation of behaviour" EXACT [] is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007610 ! behavior relationship: regulates GO:0007610 ! behavior [Term] id: GO:0050865 name: regulation of cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:ai] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0001775 ! cell activation relationship: regulates GO:0001775 ! cell activation [Term] id: GO:0050866 name: negative regulation of cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation." [GOC:ai] synonym: "down regulation of cell activation" EXACT [] synonym: "down-regulation of cell activation" EXACT [] synonym: "downregulation of cell activation" EXACT [] synonym: "inhibition of cell activation" NARROW [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0050865 ! regulation of cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0001775 ! cell activation relationship: negatively_regulates GO:0001775 ! cell activation [Term] id: GO:0050867 name: positive regulation of cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of activation." [GOC:ai] synonym: "activation of cell activation" NARROW [] synonym: "stimulation of cell activation" NARROW [] synonym: "up regulation of cell activation" EXACT [] synonym: "up-regulation of cell activation" EXACT [] synonym: "upregulation of cell activation" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0050865 ! regulation of cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0001775 ! cell activation relationship: positively_regulates GO:0001775 ! cell activation [Term] id: GO:0050896 name: response to stimulus namespace: biological_process alt_id: GO:0051869 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir synonym: "physiological response to stimulus" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0050920 name: regulation of chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0040012 ! regulation of locomotion intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006935 ! chemotaxis relationship: regulates GO:0006935 ! chemotaxis [Term] id: GO:0050921 name: positive regulation of chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai] synonym: "activation of chemotaxis" NARROW [] synonym: "stimulation of chemotaxis" NARROW [] synonym: "up regulation of chemotaxis" EXACT [] synonym: "up-regulation of chemotaxis" EXACT [] synonym: "upregulation of chemotaxis" EXACT [] is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0050920 ! regulation of chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006935 ! chemotaxis relationship: positively_regulates GO:0006935 ! chemotaxis [Term] id: GO:0050922 name: negative regulation of chemotaxis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai] synonym: "down regulation of chemotaxis" EXACT [] synonym: "down-regulation of chemotaxis" EXACT [] synonym: "downregulation of chemotaxis" EXACT [] synonym: "inhibition of chemotaxis" NARROW [] is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0050920 ! regulation of chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006935 ! chemotaxis relationship: negatively_regulates GO:0006935 ! chemotaxis [Term] id: GO:0051037 name: regulation of transcription involved in meiotic cell cycle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription as part of a meiotic cell cycle." [GOC:go_curators] synonym: "meiotic regulation of transcription" EXACT [] synonym: "regulation of transcription, meiotic" EXACT [GOC:mah] is_a: GO:0006355 ! regulation of transcription, DNA-templated is_a: GO:0022414 ! reproductive process intersection_of: GO:0006355 ! regulation of transcription, DNA-templated intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0051038 name: negative regulation of transcription involved in meiotic cell cycle namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription involved in the meiotic cell cycle." [GOC:ai] synonym: "down regulation of transcription during meiosis" EXACT [GOC:mah] synonym: "down-regulation of transcription during meiosis" EXACT [GOC:mah] synonym: "downregulation of transcription during meiosis" EXACT [GOC:mah] synonym: "inhibition of transcription during meiosis" NARROW [GOC:mah] synonym: "meiotic repression of transcription" EXACT [] synonym: "negative regulation of meiotic transcription" EXACT [] synonym: "negative regulation of transcription, meiotic" EXACT [GOC:mah] is_a: GO:0045892 ! negative regulation of transcription, DNA-templated is_a: GO:0051037 ! regulation of transcription involved in meiotic cell cycle intersection_of: GO:0045892 ! negative regulation of transcription, DNA-templated intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0051039 name: positive regulation of transcription involved in meiotic cell cycle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription as part of a meiotic cell cycle." [GOC:ai] synonym: "activation of transcription during meiosis" NARROW [GOC:mah] synonym: "positive regulation of meiotic transcription" EXACT [] synonym: "positive regulation of transcription, meiotic" EXACT [GOC:mah] synonym: "stimulation of transcription during meiosis" NARROW [GOC:mah] synonym: "up regulation of transcription during meiosis" EXACT [GOC:mah] synonym: "up-regulation of transcription during meiosis" EXACT [GOC:mah] synonym: "upregulation of transcription during meiosis" EXACT [GOC:mah] is_a: GO:0045893 ! positive regulation of transcription, DNA-templated is_a: GO:0051037 ! regulation of transcription involved in meiotic cell cycle intersection_of: GO:0045893 ! positive regulation of transcription, DNA-templated intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0051049 name: regulation of transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_yeast is_a: GO:0032879 ! regulation of localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006810 ! transport relationship: regulates GO:0006810 ! transport [Term] id: GO:0051050 name: positive regulation of transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of transport" NARROW [] synonym: "stimulation of transport" NARROW [] synonym: "up regulation of transport" EXACT [] synonym: "up-regulation of transport" EXACT [] synonym: "upregulation of transport" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006810 ! transport relationship: positively_regulates GO:0006810 ! transport [Term] id: GO:0051051 name: negative regulation of transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of transport" EXACT [] synonym: "down-regulation of transport" EXACT [] synonym: "downregulation of transport" EXACT [] synonym: "inhibition of transport" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006810 ! transport relationship: negatively_regulates GO:0006810 ! transport [Term] id: GO:0051093 name: negative regulation of developmental process namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] synonym: "down regulation of developmental process" EXACT [] synonym: "down-regulation of developmental process" EXACT [] synonym: "downregulation of developmental process" EXACT [] synonym: "inhibition of developmental process" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0032502 ! developmental process relationship: negatively_regulates GO:0032502 ! developmental process [Term] id: GO:0051094 name: positive regulation of developmental process namespace: biological_process def: "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] synonym: "activation of developmental process" NARROW [] synonym: "stimulation of developmental process" NARROW [] synonym: "up regulation of developmental process" EXACT [] synonym: "up-regulation of developmental process" EXACT [] synonym: "upregulation of developmental process" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0032502 ! developmental process relationship: positively_regulates GO:0032502 ! developmental process [Term] id: GO:0051128 name: regulation of cellular component organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] synonym: "regulation of cell organisation" RELATED [GOC:mah] synonym: "regulation of cell organization" RELATED [GOC:mah] synonym: "regulation of cellular component organisation" EXACT [] synonym: "regulation of cellular component organization and biogenesis" RELATED [GOC:mah] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016043 ! cellular component organization relationship: regulates GO:0016043 ! cellular component organization [Term] id: GO:0051129 name: negative regulation of cellular component organization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] synonym: "down regulation of cell organization" EXACT [] synonym: "down-regulation of cell organization" EXACT [] synonym: "downregulation of cell organization" EXACT [] synonym: "inhibition of cell organization" NARROW [] synonym: "negative regulation of cell organisation" RELATED [GOC:mah] synonym: "negative regulation of cellular component organization and biogenesis" RELATED [GOC:mah] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0016043 ! cellular component organization relationship: negatively_regulates GO:0016043 ! cellular component organization [Term] id: GO:0051130 name: positive regulation of cellular component organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] synonym: "activation of cell organization" NARROW [] synonym: "positive regulation of cell organisation" EXACT [] synonym: "positive regulation of cellular component organization and biogenesis" RELATED [GOC:mah] synonym: "stimulation of cell organization" NARROW [] synonym: "up regulation of cell organization" EXACT [] synonym: "up-regulation of cell organization" EXACT [] synonym: "upregulation of cell organization" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0016043 ! cellular component organization relationship: positively_regulates GO:0016043 ! cellular component organization [Term] id: GO:0051146 name: striated muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle." [CL:0000737, GOC:ai] synonym: "voluntary muscle cell differentiation" NARROW [] is_a: GO:0042692 ! muscle cell differentiation [Term] id: GO:0051147 name: regulation of muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0042692 ! muscle cell differentiation relationship: regulates GO:0042692 ! muscle cell differentiation [Term] id: GO:0051148 name: negative regulation of muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai] synonym: "down regulation of muscle cell differentiation" EXACT [] synonym: "down-regulation of muscle cell differentiation" EXACT [] synonym: "downregulation of muscle cell differentiation" EXACT [] synonym: "inhibition of muscle cell differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0051147 ! regulation of muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0042692 ! muscle cell differentiation relationship: negatively_regulates GO:0042692 ! muscle cell differentiation [Term] id: GO:0051149 name: positive regulation of muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai] synonym: "activation of muscle cell differentiation" NARROW [] synonym: "stimulation of muscle cell differentiation" NARROW [] synonym: "up regulation of muscle cell differentiation" EXACT [] synonym: "up-regulation of muscle cell differentiation" EXACT [] synonym: "upregulation of muscle cell differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0051147 ! regulation of muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0042692 ! muscle cell differentiation relationship: positively_regulates GO:0042692 ! muscle cell differentiation [Term] id: GO:0051153 name: regulation of striated muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai] is_a: GO:0051147 ! regulation of muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0051146 ! striated muscle cell differentiation relationship: regulates GO:0051146 ! striated muscle cell differentiation [Term] id: GO:0051154 name: negative regulation of striated muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai] synonym: "down regulation of striated muscle cell differentiation" EXACT [] synonym: "down-regulation of striated muscle cell differentiation" EXACT [] synonym: "downregulation of striated muscle cell differentiation" EXACT [] synonym: "inhibition of striated muscle cell differentiation" NARROW [] is_a: GO:0051148 ! negative regulation of muscle cell differentiation is_a: GO:0051153 ! regulation of striated muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0051146 ! striated muscle cell differentiation relationship: negatively_regulates GO:0051146 ! striated muscle cell differentiation [Term] id: GO:0051155 name: positive regulation of striated muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai] synonym: "activation of striated muscle cell differentiation" NARROW [] synonym: "stimulation of striated muscle cell differentiation" NARROW [] synonym: "up regulation of striated muscle cell differentiation" EXACT [] synonym: "up-regulation of striated muscle cell differentiation" EXACT [] synonym: "upregulation of striated muscle cell differentiation" EXACT [] is_a: GO:0051149 ! positive regulation of muscle cell differentiation is_a: GO:0051153 ! regulation of striated muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0051146 ! striated muscle cell differentiation relationship: positively_regulates GO:0051146 ! striated muscle cell differentiation [Term] id: GO:0051171 name: regulation of nitrogen compound metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb] synonym: "regulation of nitrogen metabolic process" EXACT [GOC:tb] synonym: "regulation of nitrogen metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006807 ! nitrogen compound metabolic process relationship: regulates GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0051172 name: negative regulation of nitrogen compound metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb] synonym: "down regulation of nitrogen metabolic process" EXACT [] synonym: "down-regulation of nitrogen metabolic process" EXACT [] synonym: "downregulation of nitrogen metabolic process" EXACT [] synonym: "inhibition of nitrogen metabolic process" NARROW [] synonym: "negative regulation of nitrogen metabolic process" EXACT [GOC:tb] synonym: "negative regulation of nitrogen metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006807 ! nitrogen compound metabolic process relationship: negatively_regulates GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0051173 name: positive regulation of nitrogen compound metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb] synonym: "activation of nitrogen metabolic process" NARROW [] synonym: "positive regulation of nitrogen metabolic process" EXACT [GOC:tb] synonym: "positive regulation of nitrogen metabolism" EXACT [] synonym: "stimulation of nitrogen metabolic process" NARROW [] synonym: "up regulation of nitrogen metabolic process" EXACT [] synonym: "up-regulation of nitrogen metabolic process" EXACT [] synonym: "upregulation of nitrogen metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006807 ! nitrogen compound metabolic process relationship: positively_regulates GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0051174 name: regulation of phosphorus metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai] synonym: "regulation of phosphorus metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006793 ! phosphorus metabolic process relationship: regulates GO:0006793 ! phosphorus metabolic process [Term] id: GO:0051179 name: localization namespace: biological_process alt_id: GO:1902578 def: "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos] subset: goslim_pir synonym: "establishment and maintenance of cellular component location" NARROW [] synonym: "establishment and maintenance of localization" EXACT [] synonym: "establishment and maintenance of position" EXACT [] synonym: "establishment and maintenance of substance location" NARROW [] synonym: "establishment and maintenance of substrate location" NARROW [] synonym: "localisation" EXACT [GOC:mah] synonym: "single organism localization" RELATED [GOC:TermGenie] synonym: "single-organism localization" RELATED [] is_a: GO:0008150 ! biological_process created_by: jl creation_date: 2013-12-18T13:51:04Z [Term] id: GO:0051222 name: positive regulation of protein transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of protein transport" NARROW [] synonym: "stimulation of protein transport" NARROW [] synonym: "up regulation of protein transport" EXACT [] synonym: "up-regulation of protein transport" EXACT [] synonym: "upregulation of protein transport" EXACT [] is_a: GO:0051223 ! regulation of protein transport is_a: GO:1903793 ! positive regulation of anion transport is_a: GO:1904951 ! positive regulation of establishment of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0015031 ! protein transport relationship: positively_regulates GO:0015031 ! protein transport [Term] id: GO:0051223 name: regulation of protein transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0070201 ! regulation of establishment of protein localization is_a: GO:0090087 ! regulation of peptide transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0015031 ! protein transport relationship: regulates GO:0015031 ! protein transport [Term] id: GO:0051224 name: negative regulation of protein transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of protein transport" EXACT [] synonym: "down-regulation of protein transport" EXACT [] synonym: "downregulation of protein transport" EXACT [] synonym: "inhibition of protein transport" NARROW [] is_a: GO:0051223 ! regulation of protein transport is_a: GO:1903792 ! negative regulation of anion transport is_a: GO:1904950 ! negative regulation of establishment of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0015031 ! protein transport relationship: negatively_regulates GO:0015031 ! protein transport [Term] id: GO:0051225 name: spindle assembly namespace: biological_process alt_id: GO:0051226 alt_id: GO:0051227 def: "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb] synonym: "bipolar spindle biosynthesis" EXACT [] synonym: "bipolar spindle formation" EXACT [] synonym: "spindle biosynthesis" EXACT [] synonym: "spindle formation" EXACT [] is_a: GO:0007051 ! spindle organization is_a: GO:0070925 ! organelle assembly [Term] id: GO:0051234 name: establishment of localization namespace: biological_process def: "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos] subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir synonym: "establishment of localisation" EXACT [GOC:mah] is_a: GO:0051179 ! localization [Term] id: GO:0051239 name: regulation of multicellular organismal process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0032501 ! multicellular organismal process relationship: regulates GO:0032501 ! multicellular organismal process [Term] id: GO:0051240 name: positive regulation of multicellular organismal process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai] synonym: "activation of multicellular organismal process" NARROW [] synonym: "stimulation of multicellular organismal process" NARROW [] synonym: "up regulation of multicellular organismal process" EXACT [] synonym: "up-regulation of multicellular organismal process" EXACT [] synonym: "upregulation of multicellular organismal process" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0032501 ! multicellular organismal process relationship: positively_regulates GO:0032501 ! multicellular organismal process [Term] id: GO:0051241 name: negative regulation of multicellular organismal process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai] synonym: "down regulation of multicellular organismal process" EXACT [] synonym: "down-regulation of multicellular organismal process" EXACT [] synonym: "downregulation of multicellular organismal process" EXACT [] synonym: "inhibition of multicellular organismal process" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0032501 ! multicellular organismal process relationship: negatively_regulates GO:0032501 ! multicellular organismal process [Term] id: GO:0051246 name: regulation of protein metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] synonym: "regulation of protein metabolism" EXACT [] is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0019538 ! protein metabolic process relationship: regulates GO:0019538 ! protein metabolic process [Term] id: GO:0051247 name: positive regulation of protein metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] synonym: "activation of protein metabolic process" NARROW [] synonym: "positive regulation of protein metabolism" EXACT [] synonym: "stimulation of protein metabolic process" NARROW [] synonym: "up regulation of protein metabolic process" EXACT [] synonym: "up-regulation of protein metabolic process" EXACT [] synonym: "upregulation of protein metabolic process" EXACT [] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0019538 ! protein metabolic process relationship: positively_regulates GO:0019538 ! protein metabolic process [Term] id: GO:0051248 name: negative regulation of protein metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai] synonym: "down regulation of protein metabolic process" EXACT [] synonym: "down-regulation of protein metabolic process" EXACT [] synonym: "downregulation of protein metabolic process" EXACT [] synonym: "inhibition of protein metabolic process" NARROW [] synonym: "negative regulation of protein metabolism" EXACT [] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0019538 ! protein metabolic process relationship: negatively_regulates GO:0019538 ! protein metabolic process [Term] id: GO:0051252 name: regulation of RNA metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] synonym: "regulation of RNA metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016070 ! RNA metabolic process relationship: regulates GO:0016070 ! RNA metabolic process [Term] id: GO:0051253 name: negative regulation of RNA metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] synonym: "down regulation of RNA metabolic process" EXACT [] synonym: "down-regulation of RNA metabolic process" EXACT [] synonym: "downregulation of RNA metabolic process" EXACT [] synonym: "inhibition of RNA metabolic process" NARROW [] synonym: "negative regulation of RNA metabolism" EXACT [] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0016070 ! RNA metabolic process relationship: negatively_regulates GO:0016070 ! RNA metabolic process [Term] id: GO:0051254 name: positive regulation of RNA metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] synonym: "activation of RNA metabolic process" NARROW [] synonym: "positive regulation of RNA metabolism" EXACT [] synonym: "stimulation of RNA metabolic process" NARROW [] synonym: "up regulation of RNA metabolic process" EXACT [] synonym: "up-regulation of RNA metabolic process" EXACT [] synonym: "upregulation of RNA metabolic process" EXACT [] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0016070 ! RNA metabolic process relationship: positively_regulates GO:0016070 ! RNA metabolic process [Term] id: GO:0051270 name: regulation of cellular component movement namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the movement of a cellular component." [GOC:ai, GOC:dph, GOC:jl] synonym: "regulation of cell movement" RELATED [] synonym: "regulation of cellular component motion" EXACT [GOC:mah] is_a: GO:0032879 ! regulation of localization is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006928 ! movement of cell or subcellular component relationship: regulates GO:0006928 ! movement of cell or subcellular component [Term] id: GO:0051271 name: negative regulation of cellular component movement namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a cellular component." [GOC:ai, GOC:dph, GOC:jl] synonym: "negative regulation of cellular component motion" EXACT [GOC:mah] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051270 ! regulation of cellular component movement intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006928 ! movement of cell or subcellular component relationship: negatively_regulates GO:0006928 ! movement of cell or subcellular component [Term] id: GO:0051272 name: positive regulation of cellular component movement namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the movement of a cellular component." [GOC:ai, GOC:dph, GOC:jl] synonym: "positive regulation of cellular component motion" EXACT [GOC:mah] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051270 ! regulation of cellular component movement intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006928 ! movement of cell or subcellular component relationship: positively_regulates GO:0006928 ! movement of cell or subcellular component [Term] id: GO:0051276 name: chromosome organization namespace: biological_process alt_id: GO:0007001 alt_id: GO:0051277 def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir synonym: "chromosome organisation" EXACT [] synonym: "chromosome organization and biogenesis" RELATED [GOC:mah] synonym: "maintenance of genome integrity" RELATED [] synonym: "nuclear genome maintenance" RELATED [] is_a: GO:0006996 ! organelle organization [Term] id: GO:0051301 name: cell division namespace: biological_process def: "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] comment: Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir xref: Wikipedia:Cell_division is_a: GO:0009987 ! cellular process [Term] id: GO:0051302 name: regulation of cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells." [GOC:go_curators] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0051301 ! cell division relationship: regulates GO:0051301 ! cell division [Term] id: GO:0051321 name: meiotic cell cycle namespace: biological_process alt_id: GO:0007126 def: "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai] comment: Note that this term should not be confused with 'GO:0140013 ; meiotic nuclear division'. 'GO:0051321 ; meiotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140013 meiotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle. subset: goslim_drosophila subset: goslim_yeast synonym: "meiosis" RELATED [] xref: Wikipedia:Meiosis is_a: GO:0007049 ! cell cycle is_a: GO:0022414 ! reproductive process intersection_of: GO:0007049 ! cell cycle intersection_of: has_part GO:0140013 ! meiotic nuclear division relationship: has_part GO:0140013 ! meiotic nuclear division [Term] id: GO:0051336 name: regulation of hydrolase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [EC:3.-.-.-, GOC:ai] synonym: "hydrolase regulator" EXACT [] is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016787 ! hydrolase activity relationship: regulates GO:0016787 ! hydrolase activity [Term] id: GO:0051338 name: regulation of transferase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [EC:2.-.-.-, GOC:ai] comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead. subset: gocheck_do_not_manually_annotate synonym: "transferase regulator" EXACT [] is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016740 ! transferase activity relationship: regulates GO:0016740 ! transferase activity [Term] id: GO:0051341 name: regulation of oxidoreductase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [EC:1.-.-.-, GOC:ai] synonym: "oxidoreductase regulator" EXACT [] is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016491 ! oxidoreductase activity relationship: regulates GO:0016491 ! oxidoreductase activity [Term] id: GO:0051345 name: positive regulation of hydrolase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds." [GOC:ai] synonym: "activation of hydrolase activity" NARROW [] synonym: "hydrolase activator" EXACT [] synonym: "stimulation of hydrolase activity" NARROW [] synonym: "up regulation of hydrolase activity" EXACT [] synonym: "up-regulation of hydrolase activity" EXACT [] synonym: "upregulation of hydrolase activity" EXACT [] is_a: GO:0043085 ! positive regulation of catalytic activity is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0016787 ! hydrolase activity relationship: positively_regulates GO:0016787 ! hydrolase activity [Term] id: GO:0051346 name: negative regulation of hydrolase activity namespace: biological_process def: "Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds." [GOC:ai] synonym: "down regulation of hydrolase activity" EXACT [] synonym: "down-regulation of hydrolase activity" EXACT [] synonym: "downregulation of hydrolase activity" EXACT [] synonym: "hydrolase inhibitor" EXACT [] synonym: "inhibition of hydrolase activity" NARROW [] is_a: GO:0043086 ! negative regulation of catalytic activity is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0016787 ! hydrolase activity relationship: negatively_regulates GO:0016787 ! hydrolase activity [Term] id: GO:0051347 name: positive regulation of transferase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai] comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead. subset: gocheck_do_not_manually_annotate synonym: "activation of transferase activity" NARROW [] synonym: "stimulation of transferase activity" NARROW [] synonym: "transferase activator" EXACT [] synonym: "up regulation of transferase activity" EXACT [] synonym: "up-regulation of transferase activity" EXACT [] synonym: "upregulation of transferase activity" EXACT [] is_a: GO:0043085 ! positive regulation of catalytic activity is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0016740 ! transferase activity relationship: positively_regulates GO:0016740 ! transferase activity [Term] id: GO:0051348 name: negative regulation of transferase activity namespace: biological_process def: "Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai] comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead. subset: gocheck_do_not_manually_annotate synonym: "down regulation of transferase activity" EXACT [] synonym: "down-regulation of transferase activity" EXACT [] synonym: "downregulation of transferase activity" EXACT [] synonym: "inhibition of transferase activity" NARROW [] synonym: "transferase inhibitor" EXACT [] is_a: GO:0043086 ! negative regulation of catalytic activity is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0016740 ! transferase activity relationship: negatively_regulates GO:0016740 ! transferase activity [Term] id: GO:0051353 name: positive regulation of oxidoreductase activity namespace: biological_process alt_id: GO:0009391 def: "Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered." [GOC:ai] synonym: "activation of oxidoreductase activity" NARROW [] synonym: "oxidoreductase activator" EXACT [] synonym: "ribonucleotide reductase activating enzyme activity" NARROW [] synonym: "stimulation of oxidoreductase activity" NARROW [] synonym: "up regulation of oxidoreductase activity" EXACT [] synonym: "up-regulation of oxidoreductase activity" EXACT [] synonym: "upregulation of oxidoreductase activity" EXACT [] is_a: GO:0043085 ! positive regulation of catalytic activity is_a: GO:0051341 ! regulation of oxidoreductase activity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0016491 ! oxidoreductase activity relationship: positively_regulates GO:0016491 ! oxidoreductase activity [Term] id: GO:0051354 name: negative regulation of oxidoreductase activity namespace: biological_process def: "Any process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered." [GOC:ai] synonym: "down regulation of oxidoreductase activity" EXACT [] synonym: "down-regulation of oxidoreductase activity" EXACT [] synonym: "downregulation of oxidoreductase activity" EXACT [] synonym: "inhibition of oxidoreductase activity" NARROW [] synonym: "oxidoreductase inhibitor" EXACT [] is_a: GO:0043086 ! negative regulation of catalytic activity is_a: GO:0051341 ! regulation of oxidoreductase activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0016491 ! oxidoreductase activity relationship: negatively_regulates GO:0016491 ! oxidoreductase activity [Term] id: GO:0051403 name: stress-activated MAPK cascade namespace: biological_process def: "A series of molecular signals in which a stress-activated MAP kinase cascade relays one or more of the signals; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase." [GOC:ai, PMID:15936270] synonym: "MAPK11 cascade" NARROW [GOC:add] synonym: "MAPK12 cascade" NARROW [GOC:add] synonym: "MAPK13 cascade" NARROW [GOC:add] synonym: "MAPK14 cascade" NARROW [GOC:add] synonym: "p38 cascade" NARROW [GOC:add] synonym: "p38 MAPK signaling" NARROW [] synonym: "p38 MAPK signalling" NARROW [] synonym: "SAPK cascade" BROAD [GOC:add] synonym: "stress-activated MAPK signaling pathway" EXACT [] synonym: "stress-activated MAPK signalling pathway" EXACT [] synonym: "stress-activated MAPKKK cascade" EXACT [] synonym: "stress-activated MAPKKK signaling pathway" EXACT [] synonym: "stress-activated MAPKKK signalling pathway" EXACT [] is_a: GO:0000165 ! MAPK cascade is_a: GO:0031098 ! stress-activated protein kinase signaling cascade [Term] id: GO:0051445 name: regulation of meiotic cell cycle namespace: biological_process def: "Any process that modulates the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] synonym: "meiotic cell cycle modulation" EXACT [] synonym: "meiotic cell cycle regulation" EXACT [] synonym: "meiotic cell cycle regulator" RELATED [] synonym: "modulation of meiotic cell cycle progression" EXACT [] synonym: "regulation of meiotic cell cycle progression" EXACT [] synonym: "regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0051726 ! regulation of cell cycle is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0051321 ! meiotic cell cycle relationship: regulates GO:0051321 ! meiotic cell cycle [Term] id: GO:0051446 name: positive regulation of meiotic cell cycle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] synonym: "activation of progression through meiotic cell cycle" NARROW [] synonym: "positive regulation of meiotic cell cycle progression" EXACT [] synonym: "positive regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through meiotic cell cycle" NARROW [] synonym: "up regulation of progression through meiotic cell cycle" EXACT [] synonym: "up-regulation of progression through meiotic cell cycle" EXACT [] synonym: "upregulation of progression through meiotic cell cycle" EXACT [] is_a: GO:0045787 ! positive regulation of cell cycle is_a: GO:0051445 ! regulation of meiotic cell cycle is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0051321 ! meiotic cell cycle relationship: positively_regulates GO:0051321 ! meiotic cell cycle [Term] id: GO:0051447 name: negative regulation of meiotic cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] synonym: "down regulation of progression through meiotic cell cycle" EXACT [] synonym: "down-regulation of progression through meiotic cell cycle" EXACT [] synonym: "downregulation of progression through meiotic cell cycle" EXACT [] synonym: "inhibition of progression through meiotic cell cycle" NARROW [] synonym: "negative regulation of meiotic cell cycle progression" EXACT [] synonym: "negative regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0045786 ! negative regulation of cell cycle is_a: GO:0051445 ! regulation of meiotic cell cycle is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0051321 ! meiotic cell cycle relationship: negatively_regulates GO:0051321 ! meiotic cell cycle [Term] id: GO:0051493 name: regulation of cytoskeleton organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] synonym: "regulation of cytoskeleton organisation" EXACT [GOC:mah] synonym: "regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007010 ! cytoskeleton organization relationship: regulates GO:0007010 ! cytoskeleton organization [Term] id: GO:0051494 name: negative regulation of cytoskeleton organization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] synonym: "down regulation of cytoskeleton organization" EXACT [] synonym: "down-regulation of cytoskeleton organization" EXACT [] synonym: "downregulation of cytoskeleton organization" EXACT [] synonym: "inhibition of cytoskeleton organization" NARROW [] synonym: "negative regulation of cytoskeleton organisation" EXACT [GOC:mah] synonym: "negative regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0051493 ! regulation of cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007010 ! cytoskeleton organization relationship: negatively_regulates GO:0007010 ! cytoskeleton organization [Term] id: GO:0051495 name: positive regulation of cytoskeleton organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] synonym: "activation of cytoskeleton organization" NARROW [] synonym: "positive regulation of cytoskeleton organisation" EXACT [GOC:mah] synonym: "positive regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah] synonym: "stimulation of cytoskeleton organization" NARROW [] synonym: "up regulation of cytoskeleton organization" EXACT [] synonym: "up-regulation of cytoskeleton organization" EXACT [] synonym: "upregulation of cytoskeleton organization" EXACT [] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0051493 ! regulation of cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007010 ! cytoskeleton organization relationship: positively_regulates GO:0007010 ! cytoskeleton organization [Term] id: GO:0051606 name: detection of stimulus namespace: biological_process def: "The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal." [GOC:add, GOC:ai, GOC:dph, GOC:mah] subset: goslim_pir synonym: "perception of stimulus" RELATED [] synonym: "stimulus detection" EXACT [] synonym: "stimulus sensing" RELATED [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0051640 name: organelle localization namespace: biological_process def: "Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai] subset: goslim_pir synonym: "establishment and maintenance of organelle localization" EXACT [] synonym: "organelle localisation" EXACT [GOC:mah] is_a: GO:0051641 ! cellular localization [Term] id: GO:0051641 name: cellular localization namespace: biological_process alt_id: GO:1902580 def: "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw] subset: goslim_pir synonym: "cellular localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of cellular localization" EXACT [] synonym: "establishment and maintenance of localization in cell or cell membrane" EXACT [] synonym: "intracellular localization" NARROW [] synonym: "localization within cell" NARROW [] synonym: "single organism cellular localization" EXACT [GOC:TermGenie] synonym: "single-organism cellular localization" RELATED [] is_a: GO:0009987 ! cellular process is_a: GO:0051179 ! localization created_by: jl creation_date: 2013-12-18T14:04:32Z [Term] id: GO:0051648 name: vesicle localization namespace: biological_process def: "Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location." [GOC:ai] synonym: "cytoplasmic vesicle localization" EXACT [] synonym: "establishment and maintenance of vesicle localization" EXACT [] synonym: "vesicle localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization [Term] id: GO:0051649 name: establishment of localization in cell namespace: biological_process def: "Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb] synonym: "establishment of cellular localization" RELATED [GOC:dph, GOC:tb] synonym: "establishment of intracellular localization" NARROW [] synonym: "establishment of localisation in cell" EXACT [GOC:mah] synonym: "establishment of localization within cell" NARROW [] synonym: "positioning within cell" NARROW [] is_a: GO:0051234 ! establishment of localization relationship: part_of GO:0051641 ! cellular localization [Term] id: GO:0051650 name: establishment of vesicle localization namespace: biological_process def: "The directed movement of a vesicle to a specific location." [GOC:ai] subset: goslim_aspergillus synonym: "establishment of vesicle localisation" EXACT [GOC:mah] is_a: GO:0051648 ! vesicle localization is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization [Term] id: GO:0051656 name: establishment of organelle localization namespace: biological_process def: "The directed movement of an organelle to a specific location." [GOC:ai] synonym: "establishment of organelle localisation" EXACT [GOC:mah] is_a: GO:0051234 ! establishment of localization is_a: GO:0051640 ! organelle localization [Term] id: GO:0051668 name: localization within membrane namespace: biological_process def: "Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane." [GOC:ai] synonym: "establishment and maintenance of localization in membrane" EXACT [] synonym: "establishment and maintenance of position in membrane" EXACT [] synonym: "localisation within membrane" EXACT [GOC:mah] synonym: "localization to membrane" EXACT [] synonym: "positioning within membrane" NARROW [] is_a: GO:0051641 ! cellular localization intersection_of: GO:0051179 ! localization intersection_of: occurs_in GO:0016020 ! membrane relationship: occurs_in GO:0016020 ! membrane [Term] id: GO:0051674 name: localization of cell namespace: biological_process def: "Any process in which a cell is transported to, and/or maintained in, a specific location." [GOC:ai] synonym: "cell localization" EXACT [] synonym: "establishment and maintenance of cell localization" EXACT [] synonym: "establishment and maintenance of localization of cell" EXACT [] synonym: "localisation of cell" EXACT [GOC:mah] is_a: GO:0009987 ! cellular process is_a: GO:0051179 ! localization [Term] id: GO:0051703 name: biological process involved in intraspecies interaction between organisms namespace: biological_process def: "Any process in which an organism has an effect on an organism of the same species." [GOC:ai] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "intraspecies interaction between organisms" EXACT [] synonym: "intraspecies interaction with other organisms" EXACT [] is_a: GO:0008150 ! biological_process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/20191 xsd:anyURI [Term] id: GO:0051704 name: multi-organism process namespace: biological_process alt_id: GO:0051706 def: "A biological process which involves another organism of the same or different species." [GOC:jl] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "interaction between organisms" EXACT [] synonym: "physiological interaction between organisms" EXACT [] synonym: "physiological interaction with other organism" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0051716 name: cellular response to stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0009987 ! cellular process is_a: GO:0050896 ! response to stimulus [Term] id: GO:0051726 name: regulation of cell cycle namespace: biological_process alt_id: GO:0000074 def: "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_yeast synonym: "cell cycle modulation" EXACT [] synonym: "cell cycle regulation" EXACT [] synonym: "cell cycle regulator" RELATED [] synonym: "control of cell cycle progression" EXACT [] synonym: "modulation of cell cycle progression" EXACT [] synonym: "regulation of cell cycle progression" EXACT [] synonym: "regulation of progression through cell cycle" EXACT [] synonym: "tumor suppressor" RELATED [] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007049 ! cell cycle relationship: regulates GO:0007049 ! cell cycle [Term] id: GO:0051781 name: positive regulation of cell division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell division." [GOC:ai] synonym: "activation of cell division" NARROW [] synonym: "stimulation of cell division" NARROW [] synonym: "up regulation of cell division" EXACT [] synonym: "up-regulation of cell division" EXACT [] synonym: "upregulation of cell division" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0051301 ! cell division relationship: positively_regulates GO:0051301 ! cell division [Term] id: GO:0051782 name: negative regulation of cell division namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell division." [GOC:ai] synonym: "down regulation of cell division" EXACT [] synonym: "down-regulation of cell division" EXACT [] synonym: "downregulation of cell division" EXACT [] synonym: "inhibition of cell division" NARROW [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0051301 ! cell division relationship: negatively_regulates GO:0051301 ! cell division [Term] id: GO:0051783 name: regulation of nuclear division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0000280 ! nuclear division relationship: regulates GO:0000280 ! nuclear division [Term] id: GO:0051784 name: negative regulation of nuclear division namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] synonym: "down regulation of nuclear division" EXACT [] synonym: "down-regulation of nuclear division" EXACT [] synonym: "downregulation of nuclear division" EXACT [] synonym: "inhibition of nuclear division" NARROW [] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0000280 ! nuclear division relationship: negatively_regulates GO:0000280 ! nuclear division [Term] id: GO:0051785 name: positive regulation of nuclear division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] synonym: "activation of nuclear division" NARROW [] synonym: "stimulation of nuclear division" NARROW [] synonym: "up regulation of nuclear division" EXACT [] synonym: "up-regulation of nuclear division" EXACT [] synonym: "upregulation of nuclear division" EXACT [] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0000280 ! nuclear division relationship: positively_regulates GO:0000280 ! nuclear division [Term] id: GO:0051896 name: regulation of protein kinase B signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B." [GOC:ai] synonym: "regulation of AKT signaling cascade" RELATED [] synonym: "regulation of AKT signalling cascade" RELATED [] synonym: "regulation of PKB signaling cascade" RELATED [] synonym: "regulation of PKB signalling cascade" RELATED [] synonym: "regulation of protein kinase B signaling cascade" RELATED [GOC:signaling] synonym: "regulation of protein kinase B signalling cascade" RELATED [] is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0043491 ! protein kinase B signaling relationship: regulates GO:0043491 ! protein kinase B signaling [Term] id: GO:0051897 name: positive regulation of protein kinase B signaling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B." [GOC:ai] synonym: "activation of protein kinase B signaling cascade" NARROW [] synonym: "positive regulation of AKT signaling cascade" RELATED [] synonym: "positive regulation of AKT signalling cascade" EXACT [] synonym: "positive regulation of PKB signaling cascade" EXACT [] synonym: "positive regulation of PKB signalling cascade" RELATED [] synonym: "positive regulation of protein kinase B signaling cascade" RELATED [GOC:signaling] synonym: "positive regulation of protein kinase B signalling cascade" RELATED [] synonym: "stimulation of protein kinase B signaling cascade" NARROW [] synonym: "up regulation of protein kinase B signaling cascade" RELATED [] synonym: "up-regulation of protein kinase B signaling cascade" RELATED [] synonym: "upregulation of protein kinase B signaling cascade" RELATED [] is_a: GO:0051896 ! regulation of protein kinase B signaling is_a: GO:1902533 ! positive regulation of intracellular signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0043491 ! protein kinase B signaling relationship: positively_regulates GO:0043491 ! protein kinase B signaling [Term] id: GO:0051898 name: negative regulation of protein kinase B signaling namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B." [GOC:ai] synonym: "down regulation of protein kinase B signaling cascade" RELATED [] synonym: "down-regulation of protein kinase B signaling cascade" RELATED [] synonym: "downregulation of protein kinase B signaling cascade" RELATED [] synonym: "inhibition of protein kinase B signaling cascade" NARROW [] synonym: "negative regulation of AKT signaling cascade" RELATED [] synonym: "negative regulation of AKT signalling cascade" EXACT [] synonym: "negative regulation of PKB signaling cascade" EXACT [] synonym: "negative regulation of PKB signalling cascade" RELATED [] synonym: "negative regulation of protein kinase B signaling cascade" RELATED [GOC:signaling] synonym: "negative regulation of protein kinase B signalling cascade" RELATED [] is_a: GO:0051896 ! regulation of protein kinase B signaling is_a: GO:1902532 ! negative regulation of intracellular signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0043491 ! protein kinase B signaling relationship: negatively_regulates GO:0043491 ! protein kinase B signaling [Term] id: GO:0051924 name: regulation of calcium ion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "regulation of calcium transport" EXACT [] is_a: GO:0010959 ! regulation of metal ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006816 ! calcium ion transport relationship: regulates GO:0006816 ! calcium ion transport [Term] id: GO:0051926 name: negative regulation of calcium ion transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of calcium ion transport" EXACT [] synonym: "down-regulation of calcium ion transport" EXACT [] synonym: "downregulation of calcium ion transport" EXACT [] synonym: "inhibition of calcium ion transport" NARROW [] synonym: "negative regulation of calcium transport" EXACT [] is_a: GO:0043271 ! negative regulation of ion transport is_a: GO:0051924 ! regulation of calcium ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006816 ! calcium ion transport relationship: negatively_regulates GO:0006816 ! calcium ion transport [Term] id: GO:0051928 name: positive regulation of calcium ion transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of calcium ion transport" NARROW [] synonym: "positive regulation of calcium transport" EXACT [] synonym: "stimulation of calcium ion transport" NARROW [] synonym: "up regulation of calcium ion transport" EXACT [] synonym: "up-regulation of calcium ion transport" EXACT [] synonym: "upregulation of calcium ion transport" EXACT [] is_a: GO:0043270 ! positive regulation of ion transport is_a: GO:0051924 ! regulation of calcium ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006816 ! calcium ion transport relationship: positively_regulates GO:0006816 ! calcium ion transport [Term] id: GO:0051960 name: regulation of nervous system development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007399 ! nervous system development relationship: regulates GO:0007399 ! nervous system development [Term] id: GO:0051961 name: negative regulation of nervous system development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai] synonym: "down regulation of nervous system development" EXACT [] synonym: "down-regulation of nervous system development" EXACT [] synonym: "downregulation of nervous system development" EXACT [] synonym: "inhibition of nervous system development" NARROW [] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0051960 ! regulation of nervous system development intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007399 ! nervous system development relationship: negatively_regulates GO:0007399 ! nervous system development [Term] id: GO:0051962 name: positive regulation of nervous system development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai] synonym: "activation of nervous system development" NARROW [] synonym: "stimulation of nervous system development" NARROW [] synonym: "up regulation of nervous system development" EXACT [] synonym: "up-regulation of nervous system development" EXACT [] synonym: "upregulation of nervous system development" EXACT [] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0051960 ! regulation of nervous system development intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007399 ! nervous system development relationship: positively_regulates GO:0007399 ! nervous system development [Term] id: GO:0052547 name: regulation of peptidase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:ai] synonym: "peptidase regulator activity" RELATED [] is_a: GO:0030162 ! regulation of proteolysis is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0008233 ! peptidase activity relationship: regulates GO:0008233 ! peptidase activity [Term] id: GO:0052548 name: regulation of endopeptidase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:ai, GOC:hjd] synonym: "protease regulator activity" NARROW [] is_a: GO:0052547 ! regulation of peptidase activity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0004175 ! endopeptidase activity relationship: regulates GO:0004175 ! endopeptidase activity [Term] id: GO:0055001 name: muscle cell development namespace: biological_process def: "The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate." [CL:0000187, GOC:devbiol] is_a: GO:0048468 ! cell development relationship: part_of GO:0042692 ! muscle cell differentiation [Term] id: GO:0055002 name: striated muscle cell development namespace: biological_process def: "The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle." [CL:0000737, GOC:devbiol] is_a: GO:0055001 ! muscle cell development relationship: part_of GO:0051146 ! striated muscle cell differentiation [Term] id: GO:0060026 name: convergent extension namespace: biological_process def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis." [GOC:dgf, GOC:dph, PMID:12062082] xref: Wikipedia:Convergent_extension is_a: GO:0002009 ! morphogenesis of an epithelium [Term] id: GO:0060027 name: convergent extension involved in gastrulation namespace: biological_process def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:dph, PMID:12062082] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060026 ! convergent extension intersection_of: GO:0060026 ! convergent extension intersection_of: part_of GO:0007369 ! gastrulation relationship: part_of GO:0007369 ! gastrulation [Term] id: GO:0060028 name: convergent extension involved in axis elongation namespace: biological_process def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contributing to the lengthening of the axis of an organism." [GOC:dph, PMID:12062082] is_a: GO:0060026 ! convergent extension intersection_of: GO:0060026 ! convergent extension intersection_of: part_of GO:0003401 ! axis elongation relationship: part_of GO:0003401 ! axis elongation [Term] id: GO:0060029 name: convergent extension involved in organogenesis namespace: biological_process def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contribution to the shaping of an organ." [GOC:dph, PMID:12062082] is_a: GO:0060026 ! convergent extension intersection_of: GO:0060026 ! convergent extension intersection_of: part_of GO:0048513 ! animal organ development relationship: part_of GO:0048513 ! animal organ development [Term] id: GO:0060047 name: heart contraction namespace: biological_process def: "The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph] synonym: "cardiac contraction" RELATED [] synonym: "heart beating" EXACT [] synonym: "hemolymph circulation" RELATED [] is_a: GO:0003015 ! heart process relationship: part_of GO:0008015 ! blood circulation [Term] id: GO:0060066 name: oviduct development namespace: biological_process def: "The reproductive developmental process whose specific outcome is the progression of an oviduct over time, from its formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism." [GOC:dph, GOC:ebc, http://www.thefreedictionary.com/oviduct] synonym: "fallopian tube development" NARROW [GOC:bf] synonym: "Mullerian tract development" RELATED [] is_a: GO:0035295 ! tube development is_a: GO:0048608 ! reproductive structure development [Term] id: GO:0060070 name: canonical Wnt signaling pathway namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:bf, GOC:dph, PMID:11532397, PMID:19619488] synonym: "canonical Wnt receptor signaling pathway" EXACT [GOC:signaling] synonym: "canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] synonym: "frizzled-1 receptor signaling pathway" NARROW [] synonym: "Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal] synonym: "Wnt receptor signaling pathway via beta-catenin" EXACT [] synonym: "Wnt receptor signalling pathway through beta-catenin" EXACT [] is_a: GO:0016055 ! Wnt signaling pathway [Term] id: GO:0060071 name: Wnt signaling pathway, planar cell polarity pathway namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity." [GOC:bf, GOC:dph, PMID:11532397] synonym: "non-canonical Wnt signaling pathway" RELATED [GOC:bf] synonym: "PCP pathway" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "planar cell polarity pathway" EXACT [GOC:cjm] synonym: "Wnt receptor signaling pathway, planar cell polarity pathway" EXACT [] synonym: "Wnt receptor signalling pathway, planar cell polarity pathway" EXACT [] synonym: "Wnt-activated signaling pathway, planar cell polarity pathway" EXACT [GOC:signaling] synonym: "Wnt-JNK signaling pathway" RELATED [GOC:bf] synonym: "Wnt-PCP signaling pathway" RELATED [GOC:rph] is_a: GO:0035567 ! non-canonical Wnt signaling pathway is_a: GO:0090175 ! regulation of establishment of planar polarity [Term] id: GO:0060236 name: regulation of mitotic spindle organization namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of mitotic spindle organisation" EXACT [GOC:mah] synonym: "regulation of mitotic spindle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0090224 ! regulation of spindle organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007052 ! mitotic spindle organization relationship: regulates GO:0007052 ! mitotic spindle organization [Term] id: GO:0060255 name: regulation of macromolecule metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0043170 ! macromolecule metabolic process relationship: regulates GO:0043170 ! macromolecule metabolic process [Term] id: GO:0060259 name: regulation of feeding behavior namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of feeding behaviour" EXACT [GOC:dph, GOC:tb] is_a: GO:0050795 ! regulation of behavior intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007631 ! feeding behavior relationship: regulates GO:0007631 ! feeding behavior [Term] id: GO:0060271 name: cilium assembly namespace: biological_process alt_id: GO:0042384 def: "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "ciliogenesis" EXACT [] synonym: "cilium assembly" EXACT [] synonym: "cilium biogenesis" RELATED [GOC:mah] synonym: "cilium formation" EXACT [] synonym: "cilium morphogenesis" RELATED [] synonym: "cilium organization" RELATED [GOC:dph] synonym: "microtubule-based flagellum assembly" EXACT [] xref: Reactome:R-HSA-5617833.2 is_a: GO:0044782 ! cilium organization is_a: GO:0070925 ! organelle assembly is_a: GO:0120031 ! plasma membrane bounded cell projection assembly relationship: has_part GO:0035082 ! axoneme assembly relationship: has_part GO:0035735 ! intraciliary transport involved in cilium assembly relationship: has_part GO:0061512 ! protein localization to cilium relationship: has_part GO:0097712 ! vesicle targeting, trans-Golgi to periciliary membrane compartment relationship: has_part GO:1905349 ! ciliary transition zone assembly property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3312 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0060284 name: regulation of cell development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0048468 ! cell development relationship: regulates GO:0048468 ! cell development [Term] id: GO:0060297 name: regulation of sarcomere organization namespace: biological_process def: "Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of sarcomere organisation" EXACT [GOC:mah] is_a: GO:0110020 ! regulation of actomyosin structure organization is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0045214 ! sarcomere organization relationship: regulates GO:0045214 ! sarcomere organization [Term] id: GO:0060298 name: positive regulation of sarcomere organization namespace: biological_process def: "Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of sarcomere organisation" EXACT [GOC:mah] is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:0060297 ! regulation of sarcomere organization is_a: GO:1902905 ! positive regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0045214 ! sarcomere organization relationship: positively_regulates GO:0045214 ! sarcomere organization [Term] id: GO:0060299 name: negative regulation of sarcomere organization namespace: biological_process def: "Any process that decreases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of sarcomere organisation" EXACT [GOC:mah] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:0060297 ! regulation of sarcomere organization is_a: GO:1902116 ! negative regulation of organelle assembly is_a: GO:1902904 ! negative regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0045214 ! sarcomere organization relationship: negatively_regulates GO:0045214 ! sarcomere organization [Term] id: GO:0060327 name: cytoplasmic actin-based contraction involved in cell motility namespace: biological_process def: "The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell from one place to another." [GOC:dph] is_a: GO:0070252 ! actin-mediated cell contraction intersection_of: GO:0070252 ! actin-mediated cell contraction intersection_of: part_of GO:0048870 ! cell motility relationship: part_of GO:0048870 ! cell motility [Term] id: GO:0060341 name: regulation of cellular localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb] synonym: "regulation of cellular localisation" EXACT [GOC:mah] is_a: GO:0032879 ! regulation of localization is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0051641 ! cellular localization relationship: regulates GO:0051641 ! cellular localization [Term] id: GO:0060389 name: pathway-restricted SMAD protein phosphorylation namespace: biological_process def: "The process of introducing a phosphate group on to a pathway restricted SMAD protein. A pathway restricted SMAD protein is an effector protein that acts directly downstream of the transforming growth factor family receptor." [GOC:dph, ISBN:3527303782] synonym: "pathway restricted SMAD protein phosphorylation" EXACT [GOC:rl] synonym: "R-SMAD protein phosphorylation" EXACT [GOC:rl] synonym: "receptor regulated SMAD protein phosphorylation" EXACT [GOC:rl] synonym: "receptor-regulated SMAD protein phosphorylation" EXACT [GOC:rl] is_a: GO:0006468 ! protein phosphorylation relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0060393 name: regulation of pathway-restricted SMAD protein phosphorylation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0001932 ! regulation of protein phosphorylation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0060389 ! pathway-restricted SMAD protein phosphorylation relationship: regulates GO:0060389 ! pathway-restricted SMAD protein phosphorylation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0060394 name: negative regulation of pathway-restricted SMAD protein phosphorylation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0001933 ! negative regulation of protein phosphorylation is_a: GO:0060393 ! regulation of pathway-restricted SMAD protein phosphorylation is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0060389 ! pathway-restricted SMAD protein phosphorylation relationship: negatively_regulates GO:0060389 ! pathway-restricted SMAD protein phosphorylation [Term] id: GO:0060419 name: heart growth namespace: biological_process def: "The increase in size or mass of the heart." [GOC:dph, GOC:tb] is_a: GO:0035265 ! organ growth relationship: part_of GO:0007507 ! heart development [Term] id: GO:0060420 name: regulation of heart growth namespace: biological_process def: "Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:dph, GOC:tb] is_a: GO:0046620 ! regulation of organ growth is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0060419 ! heart growth relationship: regulates GO:0060419 ! heart growth [Term] id: GO:0060421 name: positive regulation of heart growth namespace: biological_process def: "Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0046622 ! positive regulation of organ growth is_a: GO:0060420 ! regulation of heart growth intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0060419 ! heart growth relationship: positively_regulates GO:0060419 ! heart growth [Term] id: GO:0060429 name: epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung] subset: goslim_drosophila is_a: GO:0009888 ! tissue development [Term] id: GO:0060466 name: activation of meiosis involved in egg activation namespace: biological_process def: "Any process that starts the inactive process of meiosis in an egg after the egg has been fertilized or physiologically activated. Eggs generally arrest in meiosis and complete the process after activation." [GOC:dph] synonym: "reactivation of meiosis after fertilization" NARROW [GOC:dph] synonym: "resumption of meiosis involved in egg activation" EXACT [GOC:dph] is_a: GO:0022414 ! reproductive process is_a: GO:0090427 ! activation of meiosis intersection_of: GO:0090427 ! activation of meiosis intersection_of: part_of GO:0007343 ! egg activation relationship: part_of GO:0007343 ! egg activation [Term] id: GO:0060467 name: negative regulation of fertilization namespace: biological_process def: "Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:dph] is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0080154 ! regulation of fertilization is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009566 ! fertilization relationship: negatively_regulates GO:0009566 ! fertilization [Term] id: GO:0060468 name: prevention of polyspermy namespace: biological_process def: "The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg." [GOC:dph] synonym: "negative regulation of fertilization involved in egg activation" EXACT [GOC:dph] synonym: "polyspermy block" EXACT [GOC:dph] is_a: GO:0022414 ! reproductive process is_a: GO:0060467 ! negative regulation of fertilization intersection_of: GO:0060467 ! negative regulation of fertilization intersection_of: part_of GO:0007343 ! egg activation relationship: part_of GO:0007343 ! egg activation [Term] id: GO:0060469 name: positive regulation of transcription involved in egg activation namespace: biological_process def: "Any process that increases the rate, frequency or extent of transcription as a part of the process of egg activation." [GOC:dph] synonym: "activation of the egg genome" RELATED [GOC:dph] synonym: "activation of the maternal genome" RELATED [GOC:dph] is_a: GO:0022414 ! reproductive process is_a: GO:0045893 ! positive regulation of transcription, DNA-templated intersection_of: GO:0045893 ! positive regulation of transcription, DNA-templated intersection_of: part_of GO:0007343 ! egg activation relationship: part_of GO:0007343 ! egg activation [Term] id: GO:0060491 name: regulation of cell projection assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cell projection assembly." [GOC:dph, GOC:tb] synonym: "regulation of cell projection formation" RELATED [GOC:dph, GOC:tb] is_a: GO:0031344 ! regulation of cell projection organization is_a: GO:0044087 ! regulation of cellular component biogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0030031 ! cell projection assembly relationship: regulates GO:0030031 ! cell projection assembly [Term] id: GO:0060548 name: negative regulation of cell death namespace: biological_process def: "Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010941 ! regulation of cell death is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0008219 ! cell death relationship: negatively_regulates GO:0008219 ! cell death created_by: dph creation_date: 2009-04-13T01:56:10Z [Term] id: GO:0060560 name: developmental growth involved in morphogenesis namespace: biological_process def: "The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape." [GOC:dph] synonym: "differential growth" EXACT [GOC:dph] is_a: GO:0048589 ! developmental growth intersection_of: GO:0048589 ! developmental growth intersection_of: part_of GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0009653 ! anatomical structure morphogenesis created_by: dph creation_date: 2009-04-28T08:42:53Z [Term] id: GO:0060561 name: apoptotic process involved in morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of an anatomical structure." [GOC:dph, GOC:mtg_apoptosis] synonym: "apoptosis involved in development" RELATED [] synonym: "apoptosis involved in morphogenesis" NARROW [] synonym: "morphogenetic apoptosis" RELATED [GOC:dph] is_a: GO:1902742 ! apoptotic process involved in development intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0009653 ! anatomical structure morphogenesis created_by: dph creation_date: 2009-04-28T09:17:27Z [Term] id: GO:0060562 name: epithelial tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:dph] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0035239 ! tube morphogenesis created_by: dph creation_date: 2009-04-28T09:33:36Z [Term] id: GO:0060606 name: tube closure namespace: biological_process def: "Creation of the central hole of a tube in an anatomical structure by sealing the edges of an epithelial fold." [GOC:dph] is_a: GO:0035148 ! tube formation created_by: dph creation_date: 2009-05-15T09:44:07Z [Term] id: GO:0060627 name: regulation of vesicle-mediated transport namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016192 ! vesicle-mediated transport relationship: regulates GO:0016192 ! vesicle-mediated transport created_by: dph creation_date: 2009-05-18T02:29:43Z [Term] id: GO:0060632 name: regulation of microtubule-based movement namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins." [GOC:dph, GOC:tb] is_a: GO:0032886 ! regulation of microtubule-based process is_a: GO:0051270 ! regulation of cellular component movement intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007018 ! microtubule-based movement relationship: regulates GO:0007018 ! microtubule-based movement created_by: dph creation_date: 2009-05-18T03:07:02Z [Term] id: GO:0060804 name: positive regulation of Wnt signaling pathway by BMP signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that results in an increase in the rate, frequency or extent of a Wnt signaling pathway." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "positive regulation of WNT receptor signaling pathway by BMP signaling pathway" EXACT [GOC:bf] synonym: "positive regulation of Wnt receptor signaling pathway by BMP signaling pathway" EXACT [] synonym: "positive regulation of WNT receptor signalling pathway by BMP signalling pathway" EXACT [GOC:mah] synonym: "positive regulation of Wnt-activated signaling pathway by BMP signaling pathway" EXACT [GOC:signaling] is_a: GO:0030177 ! positive regulation of Wnt signaling pathway is_a: GO:0030509 ! BMP signaling pathway intersection_of: GO:0030509 ! BMP signaling pathway intersection_of: positively_regulates GO:0016055 ! Wnt signaling pathway created_by: dph creation_date: 2009-08-06T01:52:48Z [Term] id: GO:0060828 name: regulation of canonical Wnt signaling pathway namespace: biological_process alt_id: GO:0035411 alt_id: GO:0035412 def: "Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "catenin import into nucleus" NARROW [] synonym: "regulation of canonical Wnt receptor signaling pathway" EXACT [] synonym: "regulation of canonical Wnt receptor signalling pathway" EXACT [GOC:mah] synonym: "regulation of canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] synonym: "regulation of catenin import into nucleus" NARROW [] synonym: "regulation of catenin protein nuclear translocation" NARROW [GOC:mah] synonym: "regulation of Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal] is_a: GO:0030111 ! regulation of Wnt signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0060070 ! canonical Wnt signaling pathway relationship: regulates GO:0060070 ! canonical Wnt signaling pathway property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/13686 xsd:anyURI property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/15268 xsd:anyURI created_by: dph creation_date: 2009-08-11T01:54:47Z [Term] id: GO:0060972 name: left/right pattern formation namespace: biological_process def: "The pattern specification process that results in the subdivision of the left/right axis in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:mtg_heart] is_a: GO:0003002 ! regionalization created_by: dph creation_date: 2009-10-06T10:25:58Z [Term] id: GO:0060973 name: cell migration involved in heart development namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ." [GOC:mtg_heart] is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: part_of GO:0007507 ! heart development relationship: part_of GO:0007507 ! heart development created_by: dph creation_date: 2009-10-06T10:53:49Z [Term] id: GO:0061024 name: membrane organization namespace: biological_process alt_id: GO:0016044 alt_id: GO:0044802 def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe synonym: "cellular membrane organisation" EXACT [] synonym: "cellular membrane organization" EXACT [] synonym: "membrane organisation" EXACT [GOC:mah] synonym: "membrane organization and biogenesis" RELATED [GOC:mah] synonym: "single-organism membrane organization" RELATED [] is_a: GO:0016043 ! cellular component organization created_by: jl creation_date: 2010-02-08T02:43:11Z [Term] id: GO:0061041 name: regulation of wound healing namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF, GOC:dph] is_a: GO:1903034 ! regulation of response to wounding intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0042060 ! wound healing relationship: regulates GO:0042060 ! wound healing created_by: dph creation_date: 2010-02-25T10:14:37Z [Term] id: GO:0061045 name: negative regulation of wound healing namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:dph] is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0061041 ! regulation of wound healing is_a: GO:1903035 ! negative regulation of response to wounding intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0042060 ! wound healing relationship: negatively_regulates GO:0042060 ! wound healing created_by: dph creation_date: 2010-02-25T10:33:30Z [Term] id: GO:0061053 name: somite development namespace: biological_process def: "The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [GOC:dph] is_a: GO:0060429 ! epithelium development relationship: part_of GO:0009790 ! embryo development created_by: dph creation_date: 2010-03-02T12:05:13Z [Term] id: GO:0061061 name: muscle structure development namespace: biological_process def: "The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms." [GOC:dph] subset: goslim_drosophila is_a: GO:0048856 ! anatomical structure development created_by: dph creation_date: 2010-03-09T08:55:14Z [Term] id: GO:0061117 name: negative regulation of heart growth namespace: biological_process def: "Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:dph, GOC:hjd] is_a: GO:0046621 ! negative regulation of organ growth is_a: GO:0060420 ! regulation of heart growth intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0060419 ! heart growth relationship: negatively_regulates GO:0060419 ! heart growth created_by: dph creation_date: 2010-05-17T07:31:28Z [Term] id: GO:0061162 name: establishment of monopolar cell polarity namespace: biological_process def: "The specification and formation of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis." [GOC:dph, GOC:vw] is_a: GO:0030010 ! establishment of cell polarity is_a: GO:0061339 ! establishment or maintenance of monopolar cell polarity created_by: dph creation_date: 2010-06-23T09:30:59Z [Term] id: GO:0061245 name: establishment or maintenance of bipolar cell polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns." [GOC:dph, GOC:vw] is_a: GO:0007163 ! establishment or maintenance of cell polarity created_by: dph creation_date: 2010-08-23T09:42:05Z [Term] id: GO:0061311 name: cell surface receptor signaling pathway involved in heart development namespace: biological_process def: "Any series of molecular signals initiated by the binding of a receptor on the surface of a cell to a physiological ligand, which contributes to the progression of the heart over time." [GOC:dph, GOC:mtg_heart, GOC:signaling] synonym: "cell surface receptor linked signaling pathway involved in heart development" EXACT [GOC:bf] synonym: "cell surface receptor linked signalling pathway involved in heart development" EXACT [GOC:mah] is_a: GO:0007166 ! cell surface receptor signaling pathway intersection_of: GO:0007166 ! cell surface receptor signaling pathway intersection_of: part_of GO:0007507 ! heart development relationship: part_of GO:0007507 ! heart development created_by: dph creation_date: 2010-09-23T09:18:32Z [Term] id: GO:0061312 name: BMP signaling pathway involved in heart development namespace: biological_process def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of the heart over time." [GOC:dph, GOC:mtg_heart] synonym: "BMP signalling pathway involved in heart development" EXACT [GOC:mah] is_a: GO:0030509 ! BMP signaling pathway is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development intersection_of: GO:0030509 ! BMP signaling pathway intersection_of: part_of GO:0007507 ! heart development created_by: dph creation_date: 2010-09-23T11:02:14Z [Term] id: GO:0061313 name: fibroblast growth factor receptor signaling pathway involved in heart development namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands and contributing to the progression of the heart over time." [GOC:mtg_heart] synonym: "fibroblast growth factor receptor signalling pathway involved in heart development" EXACT [GOC:mah] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: part_of GO:0007507 ! heart development created_by: dph creation_date: 2010-09-24T08:15:08Z [Term] id: GO:0061316 name: canonical Wnt signaling pathway involved in heart development namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the progression of the heart over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_heart] synonym: "canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:signaling] synonym: "canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah] synonym: "canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:signaling] is_a: GO:0003306 ! Wnt signaling pathway involved in heart development is_a: GO:0060070 ! canonical Wnt signaling pathway intersection_of: GO:0060070 ! canonical Wnt signaling pathway intersection_of: part_of GO:0007507 ! heart development created_by: dph creation_date: 2010-09-24T09:25:03Z [Term] id: GO:0061323 name: cell proliferation involved in heart morphogenesis namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis created_by: dph creation_date: 2010-09-28T09:05:26Z [Term] id: GO:0061339 name: establishment or maintenance of monopolar cell polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis." [GOC:dph, GOC:vw] is_a: GO:0007163 ! establishment or maintenance of cell polarity created_by: dph creation_date: 2010-09-29T09:10:05Z [Term] id: GO:0061341 name: non-canonical Wnt signaling pathway involved in heart development namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin and contributing to the progression of the heart over time." [GOC:dph, GOC:mtg_heart, PMID:16860783] synonym: "non-canonical Wnt receptor signaling pathway involved in heart development" EXACT [] synonym: "non-canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah] synonym: "non-canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:signaling] is_a: GO:0003306 ! Wnt signaling pathway involved in heart development is_a: GO:0035567 ! non-canonical Wnt signaling pathway intersection_of: GO:0035567 ! non-canonical Wnt signaling pathway intersection_of: part_of GO:0007507 ! heart development created_by: dph creation_date: 2010-09-29T11:27:34Z [Term] id: GO:0061343 name: cell adhesion involved in heart morphogenesis namespace: biological_process def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783] is_a: GO:0007155 ! cell adhesion intersection_of: GO:0007155 ! cell adhesion intersection_of: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis created_by: dph creation_date: 2010-09-29T11:34:06Z [Term] id: GO:0061344 name: regulation of cell adhesion involved in heart morphogenesis namespace: biological_process def: "Any process that modulates the extent of cell adhesion contributing to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783] is_a: GO:0030155 ! regulation of cell adhesion intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0061343 ! cell adhesion involved in heart morphogenesis relationship: regulates GO:0061343 ! cell adhesion involved in heart morphogenesis created_by: dph creation_date: 2010-09-29T11:35:27Z [Term] id: GO:0061351 name: neural precursor cell proliferation namespace: biological_process def: "The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell." [GOC:dph, GOC:yaf] is_a: GO:0008283 ! cell population proliferation created_by: dph creation_date: 2010-10-01T11:06:04Z [Term] id: GO:0061371 name: determination of heart left/right asymmetry namespace: biological_process def: "Determination of the asymmetric location of the heart with respect to the left and right halves of the organism." [GOC:dph, GOC:mtg_heart] synonym: "determination of cardiac left/right asymmetry" EXACT [GOC:dph] is_a: GO:0007368 ! determination of left/right symmetry relationship: part_of GO:0007507 ! heart development created_by: dph creation_date: 2010-11-03T02:13:58Z [Term] id: GO:0061387 name: regulation of extent of cell growth namespace: biological_process def: "Any process that modulates the extent of cell growth." [GOC:mah, GOC:vw] is_a: GO:0001558 ! regulation of cell growth relationship: part_of GO:0008361 ! regulation of cell size created_by: dph creation_date: 2011-07-14T10:15:42Z [Term] id: GO:0061458 name: reproductive system development namespace: biological_process def: "The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction." [GOC:dph] is_a: GO:0048731 ! system development created_by: dph creation_date: 2012-08-22T17:47:53Z [Term] id: GO:0061512 name: protein localization to cilium namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a cilium." [GOC:dph] is_a: GO:0033365 ! protein localization to organelle property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3312 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 created_by: dph creation_date: 2013-03-22T15:41:44Z [Term] id: GO:0061523 name: cilium disassembly namespace: biological_process def: "A cellular process that results in the breakdown of a cilium." [GOC:cilia, GOC:dph, PMID:17604723, PMID:27350441] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "cilium resorption" EXACT [GOC:dph] is_a: GO:0044782 ! cilium organization is_a: GO:1903008 ! organelle disassembly created_by: dph creation_date: 2013-04-18T14:59:59Z [Term] id: GO:0061564 name: axon development namespace: biological_process def: "The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation)." [GOC:dph, GOC:pg, GOC:pr] is_a: GO:0031175 ! neuron projection development created_by: dph creation_date: 2013-07-18T14:43:01Z [Term] id: GO:0061640 name: cytoskeleton-dependent cytokinesis namespace: biological_process def: "A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton." [GOC:dph] is_a: GO:0000910 ! cytokinesis created_by: dph creation_date: 2014-08-22T14:21:35Z [Term] id: GO:0065007 name: biological regulation namespace: biological_process def: "Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "regulation" BROAD [] is_a: GO:0008150 ! biological_process [Term] id: GO:0065008 name: regulation of biological quality namespace: biological_process def: "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] subset: goslim_pir synonym: "regulation of biological attribute" EXACT [] synonym: "regulation of biological characteristic" EXACT [] is_a: GO:0065007 ! biological regulation [Term] id: GO:0065009 name: regulation of molecular function namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete] subset: gocheck_do_not_annotate subset: goslim_pir subset: goslim_plant synonym: "regulation of a molecular function" EXACT [] is_a: GO:0065007 ! biological regulation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0003674 ! molecular_function relationship: regulates GO:0003674 ! molecular_function [Term] id: GO:0070192 name: chromosome organization involved in meiotic cell cycle namespace: biological_process def: "A process of chromosome organization that is involved in a meiotic cell cycle." [GOC:mah] synonym: "chromosome organisation involved in meiosis" EXACT [GOC:mah] synonym: "meiotic chromosome organization" EXACT [GOC:mah] is_a: GO:0051276 ! chromosome organization is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0051276 ! chromosome organization intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0070201 name: regulation of establishment of protein localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah] synonym: "regulation of establishment of protein localisation" EXACT [GOC:mah] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0045184 ! establishment of protein localization relationship: regulates GO:0045184 ! establishment of protein localization [Term] id: GO:0070252 name: actin-mediated cell contraction namespace: biological_process def: "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body." [GOC:mah] is_a: GO:0030048 ! actin filament-based movement [Term] id: GO:0070302 name: regulation of stress-activated protein kinase signaling cascade namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signaling via a stress-activated protein kinase signaling cascade." [GOC:mah] synonym: "regulation of SAPK signaling pathway" EXACT [GOC:mah] synonym: "regulation of stress-activated protein kinase signaling pathway" EXACT [] synonym: "regulation of stress-activated protein kinase signalling pathway" EXACT [GOC:mah] is_a: GO:0080135 ! regulation of cellular response to stress is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0031098 ! stress-activated protein kinase signaling cascade relationship: regulates GO:0031098 ! stress-activated protein kinase signaling cascade [Term] id: GO:0070303 name: negative regulation of stress-activated protein kinase signaling cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade." [GOC:mah] synonym: "down regulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah] synonym: "down-regulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah] synonym: "downregulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah] synonym: "inhibition of stress-activated protein kinase signaling pathway" NARROW [GOC:mah] synonym: "negative regulation of SAPK signaling pathway" EXACT [GOC:mah] synonym: "negative regulation of stress-activated protein kinase signaling pathway" EXACT [] synonym: "negative regulation of stress-activated protein kinase signalling pathway" EXACT [GOC:mah] is_a: GO:0070302 ! regulation of stress-activated protein kinase signaling cascade is_a: GO:1902532 ! negative regulation of intracellular signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0031098 ! stress-activated protein kinase signaling cascade relationship: negatively_regulates GO:0031098 ! stress-activated protein kinase signaling cascade [Term] id: GO:0070304 name: positive regulation of stress-activated protein kinase signaling cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade." [GOC:mah] synonym: "activation of stress-activated protein kinase signaling pathway" NARROW [GOC:mah] synonym: "positive regulation of SAPK signaling pathway" EXACT [GOC:mah] synonym: "positive regulation of stress-activated protein kinase signaling pathway" EXACT [] synonym: "positive regulation of stress-activated protein kinase signalling pathway" EXACT [GOC:mah] synonym: "stimulation of stress-activated protein kinase signaling pathway" NARROW [GOC:mah] synonym: "up regulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah] synonym: "up-regulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah] synonym: "upregulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah] is_a: GO:0070302 ! regulation of stress-activated protein kinase signaling cascade is_a: GO:1902533 ! positive regulation of intracellular signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0031098 ! stress-activated protein kinase signaling cascade relationship: positively_regulates GO:0031098 ! stress-activated protein kinase signaling cascade [Term] id: GO:0070507 name: regulation of microtubule cytoskeleton organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] synonym: "regulation of microtubule cytoskeleton organisation" EXACT [GOC:mah] synonym: "regulation of microtubule dynamics" EXACT [GOC:dph, GOC:tb] is_a: GO:0032886 ! regulation of microtubule-based process is_a: GO:0051493 ! regulation of cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0000226 ! microtubule cytoskeleton organization relationship: regulates GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0070570 name: regulation of neuron projection regeneration namespace: biological_process def: "Any process that modulates the rate, frequency or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage." [GOC:mah] is_a: GO:0010975 ! regulation of neuron projection development is_a: GO:0050793 ! regulation of developmental process is_a: GO:0080135 ! regulation of cellular response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0031102 ! neuron projection regeneration relationship: regulates GO:0031102 ! neuron projection regeneration created_by: mah creation_date: 2009-04-15T01:23:48Z [Term] id: GO:0070571 name: negative regulation of neuron projection regeneration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage." [GOC:mah] synonym: "growth cone collapse" RELATED [GOC:pr] is_a: GO:0010977 ! negative regulation of neuron projection development is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0070570 ! regulation of neuron projection regeneration intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0031102 ! neuron projection regeneration relationship: negatively_regulates GO:0031102 ! neuron projection regeneration created_by: mah creation_date: 2009-04-15T01:43:19Z [Term] id: GO:0070572 name: positive regulation of neuron projection regeneration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage." [GOC:mah] is_a: GO:0010976 ! positive regulation of neuron projection development is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0070570 ! regulation of neuron projection regeneration intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0031102 ! neuron projection regeneration relationship: positively_regulates GO:0031102 ! neuron projection regeneration created_by: mah creation_date: 2009-04-15T01:45:27Z [Term] id: GO:0070727 name: cellular macromolecule localization namespace: biological_process def: "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] synonym: "cellular macromolecule localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization is_a: GO:0051641 ! cellular localization created_by: mah creation_date: 2009-06-16T04:08:29Z [Term] id: GO:0070816 name: phosphorylation of RNA polymerase II C-terminal domain namespace: biological_process alt_id: GO:0016245 def: "The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683] synonym: "CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:mah] synonym: "generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:krc] synonym: "generation of II(0) form of RNA polymerase II" EXACT [GOC:krc] synonym: "hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:krc] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0006468 ! protein phosphorylation created_by: mah creation_date: 2009-07-13T04:01:19Z [Term] id: GO:0070848 name: response to growth factor namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:BHF, GOC:mah] synonym: "response to growth factor stimulus" EXACT [GOC:dos] is_a: GO:0010033 ! response to organic substance property_value: RO:0002161 NCBITaxon_Union:0000023 created_by: mah creation_date: 2009-08-04T04:24:18Z [Term] id: GO:0070887 name: cellular response to chemical stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0042221 ! response to chemical is_a: GO:0051716 ! cellular response to stimulus created_by: mah creation_date: 2009-08-27T04:41:45Z [Term] id: GO:0070925 name: organelle assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] subset: goslim_yeast is_a: GO:0006996 ! organelle organization is_a: GO:0022607 ! cellular component assembly created_by: mah creation_date: 2009-09-15T03:00:51Z [Term] id: GO:0070986 name: left/right axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the left/right axis. The left/right axis is defined by a line that runs orthogonal to both the anterior/posterior and dorsal/ventral axes. Each side is defined from the viewpoint of the organism rather of the observer (as per anatomical axes)." [GOC:dph, GOC:gvg, GOC:mah] synonym: "left-right axis specification" EXACT [GOC:mah] synonym: "left/right axis determination" RELATED [GOC:dph] is_a: GO:0009798 ! axis specification relationship: part_of GO:0060972 ! left/right pattern formation created_by: mah creation_date: 2009-10-29T01:43:34Z [Term] id: GO:0071310 name: cellular response to organic substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:mah] is_a: GO:0010033 ! response to organic substance is_a: GO:0070887 ! cellular response to chemical stimulus created_by: mah creation_date: 2009-12-10T04:46:04Z [Term] id: GO:0071363 name: cellular response to growth factor stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah] is_a: GO:0070848 ! response to growth factor is_a: GO:0071310 ! cellular response to organic substance created_by: mah creation_date: 2009-12-11T03:05:07Z [Term] id: GO:0071375 name: cellular response to peptide hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [GOC:mah] synonym: "cellular response to polypeptide hormone stimulus" EXACT [GOC:mah] is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0043434 ! response to peptide hormone is_a: GO:1901653 ! cellular response to peptide created_by: mah creation_date: 2009-12-11T03:24:18Z [Term] id: GO:0071417 name: cellular response to organonitrogen compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond." [GOC:mah] synonym: "cellular response to organic nitrogen" EXACT [GOC:mah] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0071310 ! cellular response to organic substance is_a: GO:0071495 ! cellular response to endogenous stimulus is_a: GO:1901699 ! cellular response to nitrogen compound created_by: mah creation_date: 2009-12-14T04:07:27Z [Term] id: GO:0071495 name: cellular response to endogenous stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0009719 ! response to endogenous stimulus created_by: mah creation_date: 2009-12-18T02:25:40Z [Term] id: GO:0071625 name: vocalization behavior namespace: biological_process def: "The behavior in which an organism produces sounds by a mechanism involving its respiratory system." [GOC:mah] synonym: "vocalisation behaviour" EXACT [GOC:mah] is_a: GO:0007610 ! behavior created_by: mah creation_date: 2010-02-10T11:02:58Z [Term] id: GO:0071684 name: organism emergence from protective structure namespace: biological_process def: "The developmental process in which an organism emerges from a surrounding protective structure such as an egg or pupa case." [GOC:mah] is_a: GO:0032501 ! multicellular organismal process created_by: mah creation_date: 2010-02-19T04:23:55Z [Term] id: GO:0071702 name: organic substance transport namespace: biological_process def: "The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [GOC:mah] is_a: GO:0006820 ! anion transport created_by: mah creation_date: 2010-03-08T02:15:14Z [Term] id: GO:0071704 name: organic substance metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon." [GOC:mah] synonym: "organic molecular entity metabolic process" EXACT [] synonym: "organic molecular entity metabolism" EXACT [] synonym: "organic substance metabolism" EXACT [] is_a: GO:0008152 ! metabolic process created_by: mah creation_date: 2010-03-08T03:32:18Z [Term] id: GO:0071705 name: nitrogen compound transport namespace: biological_process def: "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0006810 ! transport created_by: mah creation_date: 2010-03-08T03:56:28Z [Term] id: GO:0071772 name: response to BMP namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus." [GOC:mah, GOC:yaf] synonym: "response to BMP stimulus" EXACT [GOC:dos] synonym: "response to bone morphogenetic protein stimulus" EXACT [GOC:mah] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0070848 ! response to growth factor created_by: mah creation_date: 2010-08-31T11:02:11Z [Term] id: GO:0071773 name: cellular response to BMP stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus." [GOC:mah, GOC:yaf] synonym: "cellular response to bone morphogenetic protein stimulus" EXACT [GOC:mah] is_a: GO:0071363 ! cellular response to growth factor stimulus is_a: GO:0071495 ! cellular response to endogenous stimulus is_a: GO:0071772 ! response to BMP created_by: mah creation_date: 2010-08-31T11:04:45Z [Term] id: GO:0071774 name: response to fibroblast growth factor namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fibroblast growth factor stimulus." [GOC:mah] synonym: "response to FGF stimulus" EXACT [GOC:mah] synonym: "response to fibroblast growth factor stimulus" EXACT [GOC:dos] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0070848 ! response to growth factor created_by: mah creation_date: 2010-08-31T11:06:32Z [Term] id: GO:0071840 name: cellular component organization or biogenesis namespace: biological_process alt_id: GO:0071841 def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah] subset: goslim_flybase_ribbon subset: goslim_metagenomics synonym: "cellular component organisation or biogenesis" EXACT [GOC:mah] synonym: "cellular component organisation or biogenesis at cellular level" EXACT [GOC:mah] synonym: "cellular component organization or biogenesis at cellular level" EXACT [] is_a: GO:0009987 ! cellular process created_by: mah creation_date: 2010-09-10T01:39:16Z [Term] id: GO:0071900 name: regulation of protein serine/threonine kinase activity namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah] is_a: GO:0045859 ! regulation of protein kinase activity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0004674 ! protein serine/threonine kinase activity relationship: regulates GO:0004674 ! protein serine/threonine kinase activity created_by: mah creation_date: 2010-09-15T03:08:35Z [Term] id: GO:0071901 name: negative regulation of protein serine/threonine kinase activity namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:BHF, GOC:mah] is_a: GO:0006469 ! negative regulation of protein kinase activity is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0004674 ! protein serine/threonine kinase activity relationship: negatively_regulates GO:0004674 ! protein serine/threonine kinase activity created_by: mah creation_date: 2010-09-15T03:09:43Z [Term] id: GO:0071902 name: positive regulation of protein serine/threonine kinase activity namespace: biological_process def: "Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah] is_a: GO:0045860 ! positive regulation of protein kinase activity is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0004674 ! protein serine/threonine kinase activity relationship: positively_regulates GO:0004674 ! protein serine/threonine kinase activity created_by: mah creation_date: 2010-09-15T03:09:57Z [Term] id: GO:0071929 name: alpha-tubulin acetylation namespace: biological_process def: "The addition of an acetyl group to the lysine 40 residue of alpha-tubulin." [GOC:kmv, PMID:17786050] is_a: GO:0018393 ! internal peptidyl-lysine acetylation created_by: mah creation_date: 2010-09-28T01:46:38Z [Term] id: GO:0071944 name: cell periphery namespace: cellular_component def: "The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures." [GOC:mah] subset: goslim_flybase_ribbon is_a: GO:0110165 ! cellular anatomical entity created_by: mah creation_date: 2010-10-04T01:51:47Z [Term] id: GO:0072175 name: epithelial tube formation namespace: biological_process def: "The developmental process pertaining to the initial formation of an epithelial tube." [GOC:mtg_kidney_jan10] is_a: GO:0035148 ! tube formation relationship: part_of GO:0060562 ! epithelial tube morphogenesis created_by: mah creation_date: 2010-02-26T02:15:40Z [Term] id: GO:0072359 name: circulatory system development namespace: biological_process alt_id: GO:0072358 def: "The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009] synonym: "cardiovascular system development" NARROW [] is_a: GO:0048731 ! system development created_by: mah creation_date: 2010-11-16T11:27:39Z [Term] id: GO:0080090 name: regulation of primary metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0044238 ! primary metabolic process relationship: regulates GO:0044238 ! primary metabolic process created_by: dhl creation_date: 2009-04-22T04:30:52Z [Term] id: GO:0080134 name: regulation of response to stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006950 ! response to stress relationship: regulates GO:0006950 ! response to stress created_by: dhl creation_date: 2009-05-06T04:51:28Z [Term] id: GO:0080135 name: regulation of cellular response to stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0080134 ! regulation of response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0033554 ! cellular response to stress relationship: regulates GO:0033554 ! cellular response to stress created_by: dhl creation_date: 2009-05-06T05:02:52Z [Term] id: GO:0080154 name: regulation of fertilization namespace: biological_process def: "Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:DHL, PMID:20478994] is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009566 ! fertilization relationship: regulates GO:0009566 ! fertilization created_by: dhl creation_date: 2010-09-01T03:44:27Z [Term] id: GO:0090066 name: regulation of anatomical structure size namespace: biological_process def: "Any process that modulates the size of an anatomical structure." [GOC:dph, GOC:tb] is_a: GO:0065008 ! regulation of biological quality created_by: tb creation_date: 2009-09-02T11:00:08Z [Term] id: GO:0090068 name: positive regulation of cell cycle process namespace: biological_process def: "Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0045787 ! positive regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0022402 ! cell cycle process relationship: positively_regulates GO:0022402 ! cell cycle process created_by: tb creation_date: 2009-09-09T11:39:52Z [Term] id: GO:0090080 name: positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands resulting in an increase in the rate or frequency of a MAPKKK cascade." [GOC:dph, GOC:tb] synonym: "positive regulation of MAPKKK cascade by fibroblast growth factor receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway is_a: GO:0043410 ! positive regulation of MAPK cascade intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: positively_regulates GO:0000165 ! MAPK cascade created_by: tb creation_date: 2009-10-19T11:30:22Z [Term] id: GO:0090087 name: regulation of peptide transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0044070 ! regulation of anion transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0015833 ! peptide transport relationship: regulates GO:0015833 ! peptide transport created_by: tb creation_date: 2009-10-23T11:21:38Z [Term] id: GO:0090090 name: negative regulation of canonical Wnt signaling pathway namespace: biological_process alt_id: GO:0035414 def: "Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb] synonym: "negative regulation of canonical Wnt receptor signaling pathway" EXACT [] synonym: "negative regulation of canonical Wnt receptor signalling pathway" EXACT [GOC:mah] synonym: "negative regulation of canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] synonym: "negative regulation of catenin import into nucleus" NARROW [] synonym: "negative regulation of catenin protein nuclear translocation" NARROW [GOC:mah] synonym: "negative regulation of Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal] is_a: GO:0030178 ! negative regulation of Wnt signaling pathway is_a: GO:0060828 ! regulation of canonical Wnt signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0060070 ! canonical Wnt signaling pathway relationship: negatively_regulates GO:0060070 ! canonical Wnt signaling pathway created_by: tb creation_date: 2009-10-30T11:27:17Z [Term] id: GO:0090092 name: regulation of transmembrane receptor protein serine/threonine kinase signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb] synonym: "regulation of transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway relationship: regulates GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway created_by: tb creation_date: 2009-11-04T11:46:40Z [Term] id: GO:0090100 name: positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb] synonym: "positive regulation of transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway relationship: positively_regulates GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway created_by: tb creation_date: 2009-11-13T10:55:53Z [Term] id: GO:0090101 name: negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb] synonym: "negative regulation of transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway relationship: negatively_regulates GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway created_by: tb creation_date: 2009-11-13T10:56:52Z [Term] id: GO:0090148 name: membrane fission namespace: biological_process def: "A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "membrane scission" EXACT [] is_a: GO:0061024 ! membrane organization created_by: tb creation_date: 2009-12-08T03:06:36Z [Term] id: GO:0090162 name: establishment of epithelial cell polarity namespace: biological_process def: "The specification and formation of anisotropic intracellular organization of an epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030010 ! establishment of cell polarity created_by: tb creation_date: 2009-12-08T08:58:27Z [Term] id: GO:0090163 name: establishment of epithelial cell planar polarity namespace: biological_process def: "The specification and formation of the polarity of an epithelial cell along the plane of the epithelial tissue." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090162 ! establishment of epithelial cell polarity created_by: tb creation_date: 2009-12-08T08:59:57Z [Term] id: GO:0090169 name: regulation of spindle assembly namespace: biological_process def: "Any process that modulates the rate, frequency or extent of spindle assembly. Spindle assembly is the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of spindle formation" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090224 ! regulation of spindle organization is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0051225 ! spindle assembly relationship: regulates GO:0051225 ! spindle assembly created_by: tb creation_date: 2009-12-11T10:17:51Z [Term] id: GO:0090175 name: regulation of establishment of planar polarity namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0001736 ! establishment of planar polarity relationship: regulates GO:0001736 ! establishment of planar polarity created_by: tb creation_date: 2009-12-14T10:29:41Z [Term] id: GO:0090176 name: microtubule cytoskeleton organization involved in establishment of planar polarity namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins and contributes to the establishment of planar polarity." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "microtubule cytoskeleton organisation involved in establishment of planar polarity" EXACT [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization intersection_of: GO:0000226 ! microtubule cytoskeleton organization intersection_of: part_of GO:0001736 ! establishment of planar polarity relationship: part_of GO:0001736 ! establishment of planar polarity created_by: tb creation_date: 2009-12-14T10:34:25Z [Term] id: GO:0090177 name: establishment of planar polarity involved in neural tube closure namespace: biological_process def: "Coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0042249 ! establishment of planar polarity of embryonic epithelium is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0001736 ! establishment of planar polarity intersection_of: part_of GO:0001843 ! neural tube closure relationship: part_of GO:0001843 ! neural tube closure created_by: tb creation_date: 2009-12-14T10:38:46Z [Term] id: GO:0090178 name: regulation of establishment of planar polarity involved in neural tube closure namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the establishment of planar polarity involved in neural tube closure, the coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090175 ! regulation of establishment of planar polarity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0090177 ! establishment of planar polarity involved in neural tube closure relationship: regulates GO:0090177 ! establishment of planar polarity involved in neural tube closure created_by: tb creation_date: 2009-12-14T11:14:27Z [Term] id: GO:0090179 name: planar cell polarity pathway involved in neural tube closure namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors that modulates the establishment of planar polarity contributing to neural tube closure." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway is_a: GO:0090178 ! regulation of establishment of planar polarity involved in neural tube closure intersection_of: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway intersection_of: part_of GO:0001843 ! neural tube closure relationship: part_of GO:0001843 ! neural tube closure created_by: tb creation_date: 2009-12-14T11:20:27Z [Term] id: GO:0090224 name: regulation of spindle organization namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of spindle organisation" EXACT [GOC:mah] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007051 ! spindle organization relationship: regulates GO:0007051 ! spindle organization created_by: tb creation_date: 2010-01-13T11:04:53Z [Term] id: GO:0090243 name: fibroblast growth factor receptor signaling pathway involved in somitogenesis namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "fibroblast growth factor receptor signalling pathway involved in somitogenesis" EXACT [GOC:mah] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: part_of GO:0001756 ! somitogenesis relationship: part_of GO:0001756 ! somitogenesis created_by: tb creation_date: 2010-01-22T10:46:15Z [Term] id: GO:0090244 name: Wnt signaling pathway involved in somitogenesis namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state that contributes to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "Wnt receptor signaling pathway involved in somitogenesis" EXACT [] synonym: "Wnt receptor signalling" EXACT [GOC:mah] synonym: "Wnt-activated signaling pathway involved in somitogenesis" EXACT [GOC:signaling] is_a: GO:0016055 ! Wnt signaling pathway intersection_of: GO:0016055 ! Wnt signaling pathway intersection_of: part_of GO:0001756 ! somitogenesis relationship: part_of GO:0001756 ! somitogenesis created_by: tb creation_date: 2010-01-22T10:47:59Z [Term] id: GO:0090245 name: axis elongation involved in somitogenesis namespace: biological_process def: "The developmental growth that results in the elongation of the rostral-caudal axis that contributes to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003401 ! axis elongation intersection_of: GO:0003401 ! axis elongation intersection_of: part_of GO:0001756 ! somitogenesis relationship: part_of GO:0001756 ! somitogenesis created_by: tb creation_date: 2010-01-22T10:54:29Z [Term] id: GO:0090246 name: convergent extension involved in somitogenesis namespace: biological_process def: "The morphogenetic process in which a presomitic mesoderm narrows along the left-right axis and lengthens in the rostral-caudal axis contributing to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060027 ! convergent extension involved in gastrulation is_a: GO:0060028 ! convergent extension involved in axis elongation intersection_of: GO:0060026 ! convergent extension intersection_of: part_of GO:0001756 ! somitogenesis relationship: part_of GO:0090245 ! axis elongation involved in somitogenesis created_by: tb creation_date: 2010-01-22T10:59:06Z [Term] id: GO:0090248 name: cell migration involved in somitogenic axis elongation namespace: biological_process alt_id: GO:0090247 def: "Any process involved in the controlled self-propelled movement of a cell that contributes to somitogenic axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "cell motility involved in somitogenic axis elongation" BROAD [] is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: part_of GO:0090245 ! axis elongation involved in somitogenesis relationship: part_of GO:0090245 ! axis elongation involved in somitogenesis property_value: IAO:0000233 https://github.com/geneontology/go-annotation/issues/2040 xsd:anyURI created_by: tb creation_date: 2010-01-22T11:13:59Z [Term] id: GO:0090249 name: regulation of cell migration involved in somitogenic axis elongation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the controlled self-propelled movement of a cell that contributes to somitogenic axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of cell motility involved in somitogenic axis elongation" BROAD [] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0090248 ! cell migration involved in somitogenic axis elongation relationship: regulates GO:0090248 ! cell migration involved in somitogenic axis elongation property_value: IAO:0000233 https://github.com/geneontology/go-annotation/issues/2040 xsd:anyURI created_by: tb creation_date: 2010-01-22T11:20:05Z [Term] id: GO:0090251 name: protein localization involved in establishment of planar polarity namespace: biological_process def: "Any process in which a protein is transported to, and/or maintained in, a specific location in a cell that contributes to the establishment of planar polarity." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "protein localisation involved in establishment of planar polarity" EXACT [GOC:mah] is_a: GO:0034613 ! cellular protein localization intersection_of: GO:0008104 ! protein localization intersection_of: part_of GO:0001736 ! establishment of planar polarity relationship: part_of GO:0001736 ! establishment of planar polarity created_by: tb creation_date: 2010-01-22T11:31:32Z [Term] id: GO:0090263 name: positive regulation of canonical Wnt signaling pathway namespace: biological_process alt_id: GO:0035413 def: "Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb] synonym: "positive regulation of canonical Wnt receptor signaling pathway" EXACT [] synonym: "positive regulation of canonical Wnt receptor signalling pathway" EXACT [GOC:mah] synonym: "positive regulation of canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] synonym: "positive regulation of catenin import into nucleus" NARROW [] synonym: "positive regulation of catenin protein nuclear translocation" NARROW [GOC:mah] synonym: "positive regulation of Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal] is_a: GO:0030177 ! positive regulation of Wnt signaling pathway is_a: GO:0060828 ! regulation of canonical Wnt signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0060070 ! canonical Wnt signaling pathway relationship: positively_regulates GO:0060070 ! canonical Wnt signaling pathway created_by: tb creation_date: 2010-02-03T04:32:16Z [Term] id: GO:0090287 name: regulation of cellular response to growth factor stimulus namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:tb] is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0071363 ! cellular response to growth factor stimulus relationship: regulates GO:0071363 ! cellular response to growth factor stimulus created_by: tb creation_date: 2010-02-18T03:01:25Z [Term] id: GO:0090288 name: negative regulation of cellular response to growth factor stimulus namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:BHF] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0071363 ! cellular response to growth factor stimulus relationship: negatively_regulates GO:0071363 ! cellular response to growth factor stimulus created_by: tb creation_date: 2010-02-18T03:01:25Z [Term] id: GO:0090303 name: positive regulation of wound healing namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF] is_a: GO:0061041 ! regulation of wound healing is_a: GO:1903036 ! positive regulation of response to wounding intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0042060 ! wound healing relationship: positively_regulates GO:0042060 ! wound healing created_by: tb creation_date: 2010-03-22T02:12:03Z [Term] id: GO:0090304 name: nucleic acid metabolic process namespace: biological_process def: "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb] is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0043170 ! macromolecule metabolic process created_by: tb creation_date: 2010-04-07T10:18:47Z [Term] id: GO:0090306 name: spindle assembly involved in meiosis namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of meiosis." [GOC:tb, GOC:vw] synonym: "meiotic spindle assembly" EXACT [GOC:vw] is_a: GO:0000212 ! meiotic spindle organization is_a: GO:0051225 ! spindle assembly intersection_of: GO:0051225 ! spindle assembly intersection_of: part_of GO:0140013 ! meiotic nuclear division relationship: part_of GO:0140013 ! meiotic nuclear division created_by: tb creation_date: 2010-04-09T11:21:56Z [Term] id: GO:0090307 name: mitotic spindle assembly namespace: biological_process def: "Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied." [GOC:tb, GOC:vw] synonym: "spindle assembly involved in mitosis" EXACT [] is_a: GO:0007052 ! mitotic spindle organization is_a: GO:0051225 ! spindle assembly intersection_of: GO:0051225 ! spindle assembly intersection_of: part_of GO:0140014 ! mitotic nuclear division relationship: part_of GO:0140014 ! mitotic nuclear division created_by: tb creation_date: 2010-04-09T11:31:28Z [Term] id: GO:0090316 name: positive regulation of intracellular protein transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0051222 ! positive regulation of protein transport intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006886 ! intracellular protein transport relationship: positively_regulates GO:0006886 ! intracellular protein transport created_by: tb creation_date: 2010-04-16T03:45:07Z [Term] id: GO:0090317 name: negative regulation of intracellular protein transport namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0051224 ! negative regulation of protein transport is_a: GO:1903828 ! negative regulation of cellular protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006886 ! intracellular protein transport relationship: negatively_regulates GO:0006886 ! intracellular protein transport created_by: tb creation_date: 2010-04-16T03:45:07Z [Term] id: GO:0090325 name: regulation of locomotion involved in locomotory behavior namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0050795 ! regulation of behavior intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0031987 ! locomotion involved in locomotory behavior relationship: regulates GO:0031987 ! locomotion involved in locomotory behavior created_by: tb creation_date: 2010-05-14T10:24:29Z [Term] id: GO:0090326 name: positive regulation of locomotion involved in locomotory behavior namespace: biological_process def: "Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0048520 ! positive regulation of behavior is_a: GO:0090325 ! regulation of locomotion involved in locomotory behavior intersection_of: GO:0050789 ! regulation of biological process intersection_of: positively_regulates GO:0031987 ! locomotion involved in locomotory behavior relationship: positively_regulates GO:0031987 ! locomotion involved in locomotory behavior created_by: tb creation_date: 2010-05-14T10:26:58Z [Term] id: GO:0090327 name: negative regulation of locomotion involved in locomotory behavior namespace: biological_process def: "Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0048521 ! negative regulation of behavior is_a: GO:0090325 ! regulation of locomotion involved in locomotory behavior intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0031987 ! locomotion involved in locomotory behavior relationship: negatively_regulates GO:0031987 ! locomotion involved in locomotory behavior created_by: tb creation_date: 2010-05-14T10:26:58Z [Term] id: GO:0090427 name: activation of meiosis namespace: biological_process def: "Any process that starts the inactive process of meiosis." [GOC:dph, GOC:tb] is_a: GO:0045836 ! positive regulation of meiotic nuclear division created_by: tb creation_date: 2012-05-04T09:50:19Z [Term] id: GO:0097014 name: ciliary plasm namespace: cellular_component def: "All of the contents of a cilium, excluding the plasma membrane surrounding the cilium." [GOC:BHF, GOC:cilia, GOC:dos, PMID:17895364] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also, researchers consider the composition of both the plasm and the membrane of the cilium to be detectably different from that in the non-ciliary cytosol and plasma membrane (e.g. in terms of calcium ion concentration, membrane lipid composition, and more). For this reason, the term "ciliary plasm" is not linked to "cytoplasm". synonym: "cilial cytoplasm" RELATED [] synonym: "ciliary cytoplasm" RELATED [] synonym: "cilium cytoplasm" RELATED [] synonym: "cilium plasm" EXACT [] synonym: "microtubule-based flagellar cytoplasm" RELATED [] synonym: "microtubule-based flagellar matrix" NARROW [] synonym: "microtubule-based flagellum cytoplasm" RELATED [] synonym: "microtubule-based flagellum matrix" NARROW [] is_a: GO:0032838 ! plasma membrane bounded cell projection cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: part_of GO:0005929 ! cilium relationship: part_of GO:0005929 ! cilium created_by: pr creation_date: 2011-03-23T01:52:31Z [Term] id: GO:0097153 name: cysteine-type endopeptidase activity involved in apoptotic process namespace: molecular_function def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process." [GOC:mtg_apoptosis] synonym: "caspase activity" BROAD [] synonym: "metacaspase activity" NARROW [GOC:mtg_apoptosis] xref: Reactome:R-HSA-6800797 "The PIDDosome activates CASP2" is_a: GO:0004197 ! cysteine-type endopeptidase activity intersection_of: GO:0004197 ! cysteine-type endopeptidase activity intersection_of: part_of GO:0006915 ! apoptotic process relationship: part_of GO:0006915 ! apoptotic process created_by: pr creation_date: 2011-09-09T10:21:56Z [Term] id: GO:0097435 name: supramolecular fiber organization namespace: biological_process alt_id: GO:0043206 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr] synonym: "extracellular fibril organisation" NARROW [] synonym: "extracellular fibril organization" NARROW [] synonym: "extracellular fibril organization and biogenesis" NARROW [GOC:mah] synonym: "fibril organisation" RELATED [] synonym: "fibril organization" RELATED [] is_a: GO:0016043 ! cellular component organization created_by: pr creation_date: 2012-11-27T15:46:25Z [Term] id: GO:0097485 name: neuron projection guidance namespace: biological_process def: "The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:rl, PMID:22790009] synonym: "neurite guidance" NARROW [] synonym: "neuron process guidance" EXACT [] synonym: "neuron protrusion guidance" EXACT [] synonym: "neuronal cell projection guidance" EXACT [] is_a: GO:0006928 ! movement of cell or subcellular component relationship: part_of GO:0006935 ! chemotaxis relationship: part_of GO:0048812 ! neuron projection morphogenesis created_by: pr creation_date: 2013-07-08T13:32:37Z [Term] id: GO:0097549 name: chromatin organization involved in negative regulation of transcription namespace: biological_process alt_id: GO:1903758 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription by chromatin organization." [GOC:di, PMID:23123093] subset: gocheck_do_not_manually_annotate synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "negative regulation of global transcription from Pol II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "negative regulation of transcription by chromatin organization" EXACT [] synonym: "negative regulation of transcription from Pol II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "negative regulation of transcription from RNA polymerase II promoter by histone modification" NARROW [] synonym: "negative regulation of transcription from RNA polymerase II promoter, global by histone modification" NARROW [GOC:TermGenie] is_a: GO:0034401 ! chromatin organization involved in regulation of transcription intersection_of: GO:0006325 ! chromatin organization intersection_of: part_of GO:0045892 ! negative regulation of transcription, DNA-templated relationship: part_of GO:0045892 ! negative regulation of transcription, DNA-templated created_by: pr creation_date: 2014-01-22T08:20:50Z [Term] id: GO:0097659 name: nucleic acid-templated transcription namespace: biological_process def: "The cellular synthesis of RNA on a template of nucleic acid (DNA or RNA)." [GOC:pr, GOC:txnOH, GOC:vw] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_mouse is_a: GO:0032774 ! RNA biosynthetic process created_by: pr creation_date: 2014-10-01T13:49:27Z [Term] id: GO:0097708 name: intracellular vesicle namespace: cellular_component def: "Any vesicle that is part of the intracellular region." [GOC:vesicles] is_a: GO:0031982 ! vesicle intersection_of: GO:0031982 ! vesicle intersection_of: part_of GO:0005622 ! intracellular anatomical structure relationship: part_of GO:0005622 ! intracellular anatomical structure created_by: pr creation_date: 2016-03-29T17:39:45Z [Term] id: GO:0097712 name: vesicle targeting, trans-Golgi to periciliary membrane compartment namespace: biological_process def: "The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:cilia, PMID:20106869, PMID:23351793, PMID:24814148, PMID:26485645, Reactome:R-HSA-5620920.1] is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi relationship: part_of GO:0060271 ! cilium assembly created_by: pr creation_date: 2016-08-05T16:16:28Z [Term] id: GO:0097747 name: RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template." [GOC:pf] is_a: GO:0016779 ! nucleotidyltransferase activity is_a: GO:0140098 ! catalytic activity, acting on RNA created_by: pr creation_date: 2016-12-02T11:48:55Z [Term] id: GO:0098590 name: plasma membrane region namespace: cellular_component def: "A membrane that is a (regional) part of the plasma membrane." [GOC:dos] comment: Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass. subset: gocheck_do_not_manually_annotate synonym: "region of plasma membrane" EXACT [] is_a: GO:0016020 ! membrane intersection_of: GO:0016020 ! membrane intersection_of: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0005886 ! plasma membrane created_by: dos creation_date: 2014-03-06T11:55:32Z [Term] id: GO:0098796 name: membrane protein complex namespace: cellular_component def: "Any protein complex that is part of a membrane." [GOC:dos] subset: goslim_metagenomics is_a: GO:0032991 ! protein-containing complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: part_of GO:0016020 ! membrane relationship: part_of GO:0016020 ! membrane [Term] id: GO:0098797 name: plasma membrane protein complex namespace: cellular_component def: "Any protein complex that is part of the plasma membrane." [GOC:dos] is_a: GO:0098796 ! membrane protein complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0005886 ! plasma membrane [Term] id: GO:0098840 name: protein transport along microtubule namespace: biological_process def: "The directed movement of a protein along a microtubule, mediated by motor proteins." [PMID:25987607] synonym: "microtubule-based protein transport" BROAD [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0010970 ! transport along microtubule is_a: GO:0099118 ! microtubule-based protein transport [Term] id: GO:0099080 name: supramolecular complex namespace: cellular_component def: "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0099081 name: supramolecular polymer namespace: cellular_component def: "A polymeric supramolecular structure." [GOC:dos] is_a: GO:0099080 ! supramolecular complex [Term] id: GO:0099111 name: microtubule-based transport namespace: biological_process def: "A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194] is_a: GO:0006810 ! transport is_a: GO:0007018 ! microtubule-based movement [Term] id: GO:0099118 name: microtubule-based protein transport namespace: biological_process def: "A microtubule-based process that results in the transport of proteins." [GOC:vw] is_a: GO:0015031 ! protein transport is_a: GO:0099111 ! microtubule-based transport [Term] id: GO:0099503 name: secretory vesicle namespace: cellular_component def: "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos] subset: goslim_drosophila is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0099512 name: supramolecular fiber namespace: cellular_component alt_id: GO:0043205 def: "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos] synonym: "fibril" RELATED [] is_a: GO:0099081 ! supramolecular polymer [Term] id: GO:0099513 name: polymeric cytoskeletal fiber namespace: cellular_component def: "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos] is_a: GO:0099512 ! supramolecular fiber relationship: part_of GO:0005856 ! cytoskeleton [Term] id: GO:0099568 name: cytoplasmic region namespace: cellular_component def: "Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm." [GOC:dos] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0099738 name: cell cortex region namespace: cellular_component def: "The complete extent of cell cortex that underlies some some region of the plasma membrane." [GOC:dos] synonym: "perimembrane region" EXACT [] is_a: GO:0005938 ! cell cortex is_a: GO:0099568 ! cytoplasmic region intersection_of: GO:0005938 ! cell cortex intersection_of: part_of GO:0005938 ! cell cortex relationship: part_of GO:0005938 ! cell cortex [Term] id: GO:0100002 name: negative regulation of protein kinase activity by protein phosphorylation namespace: biological_process def: "Any protein phosphorylation process that negatively regulates protein kinase activity." [GOC:cjm, GOC:obol] is_a: GO:0006468 ! protein phosphorylation intersection_of: GO:0006468 ! protein phosphorylation intersection_of: negatively_regulates GO:0004672 ! protein kinase activity relationship: negatively_regulates GO:0004672 ! protein kinase activity created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0110020 name: regulation of actomyosin structure organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin." [GOC:lf, PMID:22790195] is_a: GO:0032956 ! regulation of actin cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0031032 ! actomyosin structure organization relationship: regulates GO:0031032 ! actomyosin structure organization created_by: kmv creation_date: 2017-06-20T19:28:58Z [Term] id: GO:0110028 name: positive regulation of mitotic spindle organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic spindle organization." [GOC:bhm, PMID:17576815] is_a: GO:0045931 ! positive regulation of mitotic cell cycle is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:0060236 ! regulation of mitotic spindle organization is_a: GO:0090068 ! positive regulation of cell cycle process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007052 ! mitotic spindle organization relationship: positively_regulates GO:0007052 ! mitotic spindle organization created_by: kmv creation_date: 2017-07-06T14:14:08Z [Term] id: GO:0110110 name: positive regulation of animal organ morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis." [GOC:kmv] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009887 ! animal organ morphogenesis relationship: positively_regulates GO:0009887 ! animal organ morphogenesis created_by: kmv creation_date: 2018-07-05T14:10:14Z [Term] id: GO:0110111 name: negative regulation of animal organ morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis." [GOC:kmv] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009887 ! animal organ morphogenesis relationship: negatively_regulates GO:0009887 ! animal organ morphogenesis created_by: kmv creation_date: 2018-07-05T14:25:21Z [Term] id: GO:0110165 name: cellular anatomical entity namespace: cellular_component def: "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [GOC:kmv] is_a: GO:0005575 ! cellular_component created_by: kmv creation_date: 2019-08-12T18:01:37Z [Term] id: GO:0120025 name: plasma membrane bounded cell projection namespace: cellular_component def: "A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] is_a: GO:0042995 ! cell projection intersection_of: GO:0042995 ! cell projection intersection_of: has_part GO:0098590 ! plasma membrane region relationship: has_part GO:0098590 ! plasma membrane region property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/13193 xsd:anyURI created_by: krc creation_date: 2017-03-21T17:26:07Z [Term] id: GO:0120031 name: plasma membrane bounded cell projection assembly namespace: biological_process def: "Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] synonym: "eupodium" NARROW [GOC:krc, GOC:rjd, PMID:10328951, PMID:9096956] is_a: GO:0030031 ! cell projection assembly is_a: GO:0120036 ! plasma membrane bounded cell projection organization property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/13298 xsd:anyURI created_by: krc creation_date: 2017-04-24T23:56:08Z [Term] id: GO:0120032 name: regulation of plasma membrane bounded cell projection assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of plasma membrane bounded cell projection assembly." [GOC:krc] is_a: GO:0060491 ! regulation of cell projection assembly is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0120031 ! plasma membrane bounded cell projection assembly relationship: regulates GO:0120031 ! plasma membrane bounded cell projection assembly property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/13298 xsd:anyURI created_by: krc creation_date: 2017-04-26T04:27:04Z [Term] id: GO:0120033 name: negative regulation of plasma membrane bounded cell projection assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane bounded cell projection assembly." [GOC:krc] is_a: GO:0031345 ! negative regulation of cell projection organization is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0120031 ! plasma membrane bounded cell projection assembly relationship: negatively_regulates GO:0120031 ! plasma membrane bounded cell projection assembly property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/13298 xsd:anyURI created_by: krc creation_date: 2017-04-26T04:34:31Z [Term] id: GO:0120034 name: positive regulation of plasma membrane bounded cell projection assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly." [GOC:krc] is_a: GO:0031346 ! positive regulation of cell projection organization is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0120031 ! plasma membrane bounded cell projection assembly relationship: positively_regulates GO:0120031 ! plasma membrane bounded cell projection assembly property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/13298 xsd:anyURI created_by: krc creation_date: 2017-04-26T04:34:45Z [Term] id: GO:0120035 name: regulation of plasma membrane bounded cell projection organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections." [GOC:krc] is_a: GO:0031344 ! regulation of cell projection organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0120036 ! plasma membrane bounded cell projection organization relationship: regulates GO:0120036 ! plasma membrane bounded cell projection organization property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/13298 xsd:anyURI created_by: krc creation_date: 2017-04-26T16:02:06Z [Term] id: GO:0120036 name: plasma membrane bounded cell projection organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon." [GOC:krc] is_a: GO:0030030 ! cell projection organization property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/13298 xsd:anyURI created_by: krc creation_date: 2017-04-26T16:07:02Z [Term] id: GO:0120039 name: plasma membrane bounded cell projection morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized." [GOC:krc] is_a: GO:0048858 ! cell projection morphogenesis property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/13298 xsd:anyURI created_by: krc creation_date: 2017-04-28T23:39:37Z [Term] id: GO:0140013 name: meiotic nuclear division namespace: biological_process def: "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [PMID:9334324] synonym: "meiosis" EXACT [] is_a: GO:0000280 ! nuclear division is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0000280 ! nuclear division intersection_of: part_of GO:0051321 ! meiotic cell cycle property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/19910 xsd:anyURI created_by: pg creation_date: 2017-03-23T09:40:00Z [Term] id: GO:0140014 name: mitotic nuclear division namespace: biological_process def: "A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [ISBN:0198547684] subset: goslim_chembl subset: goslim_generic synonym: "mitosis" EXACT [] is_a: GO:0000280 ! nuclear division is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0000280 ! nuclear division intersection_of: part_of GO:0000278 ! mitotic cell cycle property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/19910 xsd:anyURI created_by: pg creation_date: 2017-03-23T14:44:23Z [Term] id: GO:0140096 name: catalytic activity, acting on a protein namespace: molecular_function def: "Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt] is_a: GO:0003824 ! catalytic activity relationship: part_of GO:0018215 ! protein phosphopantetheinylation property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/14225 xsd:anyURI created_by: pg creation_date: 2017-09-14T10:32:59Z [Term] id: GO:0140098 name: catalytic activity, acting on RNA namespace: molecular_function def: "Catalytic activity that acts to modify RNA." [GOC:molecular_function_refactoring, GOC:pdt] is_a: GO:0003824 ! catalytic activity property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/14225 xsd:anyURI created_by: pg creation_date: 2017-09-14T12:05:21Z [Term] id: GO:0198738 name: cell-cell signaling by wnt namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another, medaited by a wnt family protein ligand. This process includes wnt signal transduction in the receiving cell, release of wnt ligand from a secreting cell as well as any processes that actively facilitate wnt transport and presentation to receptor on the recieving cell." [GOC:dos] is_a: GO:0007267 ! cell-cell signaling [Term] id: GO:1900076 name: regulation of cellular response to insulin stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf] is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0032869 ! cellular response to insulin stimulus relationship: regulates GO:0032869 ! cellular response to insulin stimulus created_by: yaf creation_date: 2012-01-31T11:22:22Z [Term] id: GO:1900077 name: negative regulation of cellular response to insulin stimulus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf] synonym: "down regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] synonym: "inhibition of cellular response to insulin stimulus" NARROW [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1900076 ! regulation of cellular response to insulin stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0032869 ! cellular response to insulin stimulus relationship: negatively_regulates GO:0032869 ! cellular response to insulin stimulus created_by: yaf creation_date: 2012-01-31T11:23:15Z [Term] id: GO:1900078 name: positive regulation of cellular response to insulin stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf] synonym: "activation of cellular response to insulin stimulus" NARROW [GOC:TermGenie] synonym: "up regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1900076 ! regulation of cellular response to insulin stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0032869 ! cellular response to insulin stimulus relationship: positively_regulates GO:0032869 ! cellular response to insulin stimulus created_by: yaf creation_date: 2012-01-31T11:24:30Z [Term] id: GO:1900094 name: regulation of transcription from RNA polymerase II promoter involved in determination of left/right symmetry namespace: biological_process def: "Any regulation of transcription from RNA polymerase II promoter that is involved in determination of left/right symmetry." [GOC:BHF, GOC:TermGenie] synonym: "global transcription regulation from Pol II promoter of determination of left/right asymmetry" RELATED [GOC:TermGenie] synonym: "global transcription regulation from Pol II promoter of determination of left/right symmetry" RELATED [GOC:TermGenie] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter of determination of left/right asymmetry" RELATED [GOC:TermGenie] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter of determination of left/right symmetry" RELATED [GOC:TermGenie] synonym: "regulation of global transcription from Pol II promoter of determination of left/right asymmetry" RELATED [GOC:TermGenie] synonym: "regulation of global transcription from Pol II promoter of determination of left/right symmetry" RELATED [GOC:TermGenie] synonym: "regulation of transcription from Pol II promoter of determination of left/right asymmetry" EXACT [GOC:TermGenie] synonym: "regulation of transcription from Pol II promoter of determination of left/right symmetry" EXACT [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter of determination of left/right asymmetry" EXACT [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter of determination of left/right symmetry" EXACT [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter, global of determination of left/right asymmetry" RELATED [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter, global of determination of left/right symmetry" RELATED [GOC:TermGenie] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: part_of GO:0007368 ! determination of left/right symmetry relationship: part_of GO:0007368 ! determination of left/right symmetry created_by: vk creation_date: 2012-02-14T10:58:20Z [Term] id: GO:1900107 name: regulation of nodal signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nodal signaling pathway." [GOC:BHF, GOC:TermGenie, GOC:vk] synonym: "regulation of nodal signaling" EXACT [GOC:TermGenie] synonym: "regulation of nodal signalling pathway" EXACT [GOC:mah] is_a: GO:0032925 ! regulation of activin receptor signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0038092 ! nodal signaling pathway relationship: regulates GO:0038092 ! nodal signaling pathway created_by: bf creation_date: 2012-02-16T03:34:19Z [Term] id: GO:1900108 name: negative regulation of nodal signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of nodal signaling pathway." [GOC:BHF, GOC:TermGenie, GOC:vk] synonym: "down regulation of nodal signaling" EXACT [GOC:TermGenie] synonym: "down regulation of nodal signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of nodal signaling" EXACT [GOC:TermGenie] synonym: "down-regulation of nodal signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of nodal signaling" EXACT [GOC:TermGenie] synonym: "downregulation of nodal signaling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of nodal signaling" NARROW [GOC:TermGenie] synonym: "inhibition of nodal signaling pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of nodal signaling" EXACT [GOC:TermGenie] synonym: "negative regulation of nodal signalling pathway" EXACT [GOC:mah] is_a: GO:0032926 ! negative regulation of activin receptor signaling pathway is_a: GO:1900107 ! regulation of nodal signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0038092 ! nodal signaling pathway relationship: negatively_regulates GO:0038092 ! nodal signaling pathway created_by: bf creation_date: 2012-02-16T03:34:23Z [Term] id: GO:1900145 name: regulation of nodal signaling pathway involved in determination of left/right asymmetry namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a nodal signaling pathway, where the nodal signaling pathway is involved in determination of left/right asymmetry." [GOC:BHF, GOC:signaling, GOC:TermGenie, GOC:vk] synonym: "regulation of nodal signalling pathway involved in determination of left/right asymmetry" EXACT [GOC:mah] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:1900107 ! regulation of nodal signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0038107 ! nodal signaling pathway involved in determination of left/right asymmetry relationship: regulates GO:0038107 ! nodal signaling pathway involved in determination of left/right asymmetry created_by: bf creation_date: 2012-03-06T11:00:32Z [Term] id: GO:1900146 name: negative regulation of nodal signaling pathway involved in determination of left/right asymmetry namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of a nodal signaling pathway, where the nodal signaling pathway is involved in determination of left/right asymmetry." [GOC:BHF, GOC:signaling, GOC:TermGenie, GOC:vk] synonym: "down regulation of nodal signaling pathway involved in determination of left/right asymmetry" EXACT [GOC:TermGenie] synonym: "down-regulation of nodal signaling pathway involved in determination of left/right asymmetry" EXACT [GOC:TermGenie] synonym: "downregulation of nodal signaling pathway involved in determination of left/right asymmetry" EXACT [GOC:TermGenie] synonym: "inhibition of nodal signaling pathway involved in determination of left/right asymmetry" NARROW [GOC:TermGenie] synonym: "negative regulation of nodal signalling pathway involved in determination of left/right asymmetry" EXACT [GOC:mah] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1900108 ! negative regulation of nodal signaling pathway is_a: GO:1900145 ! regulation of nodal signaling pathway involved in determination of left/right asymmetry intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0038107 ! nodal signaling pathway involved in determination of left/right asymmetry relationship: negatively_regulates GO:0038107 ! nodal signaling pathway involved in determination of left/right asymmetry created_by: bf creation_date: 2012-03-06T11:00:36Z [Term] id: GO:1901207 name: regulation of heart looping namespace: biological_process def: "Any process that modulates the frequency, rate or extent of heart looping." [GOC:BHF, GOC:TermGenie] synonym: "regulation of cardiac looping" EXACT [GOC:TermGenie] is_a: GO:1905330 ! regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0001947 ! heart looping relationship: regulates GO:0001947 ! heart looping created_by: rl creation_date: 2012-07-31T07:15:47Z [Term] id: GO:1901208 name: negative regulation of heart looping namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of heart looping." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of cardiac looping" EXACT [GOC:TermGenie] synonym: "down regulation of heart looping" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac looping" EXACT [GOC:TermGenie] synonym: "down-regulation of heart looping" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac looping" EXACT [GOC:TermGenie] synonym: "downregulation of heart looping" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac looping" EXACT [GOC:TermGenie] synonym: "inhibition of heart looping" NARROW [GOC:TermGenie] synonym: "negative regulation of cardiac looping" EXACT [GOC:TermGenie] is_a: GO:1901207 ! regulation of heart looping is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0001947 ! heart looping relationship: negatively_regulates GO:0001947 ! heart looping created_by: rl creation_date: 2012-07-31T07:16:10Z [Term] id: GO:1901209 name: positive regulation of heart looping namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of heart looping." [GOC:BHF, GOC:TermGenie] synonym: "activation of cardiac looping" EXACT [GOC:TermGenie] synonym: "activation of heart looping" NARROW [GOC:TermGenie] synonym: "positive regulation of cardiac looping" EXACT [GOC:TermGenie] synonym: "up regulation of cardiac looping" EXACT [GOC:TermGenie] synonym: "up regulation of heart looping" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac looping" EXACT [GOC:TermGenie] synonym: "up-regulation of heart looping" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac looping" EXACT [GOC:TermGenie] synonym: "upregulation of heart looping" EXACT [GOC:TermGenie] is_a: GO:1901207 ! regulation of heart looping is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0001947 ! heart looping relationship: positively_regulates GO:0001947 ! heart looping created_by: rl creation_date: 2012-07-31T07:16:18Z [Term] id: GO:1901213 name: regulation of transcription from RNA polymerase II promoter involved in heart development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the development of the heart over time." [GOC:BHF, GOC:TermGenie] synonym: "global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: part_of GO:0007507 ! heart development relationship: part_of GO:0007507 ! heart development created_by: rl creation_date: 2012-07-31T07:26:45Z [Term] id: GO:1901227 name: negative regulation of transcription from RNA polymerase II promoter involved in heart development namespace: biological_process def: "Any negative regulation of transcription from RNA polymerase II promoter that is involved in heart development." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "down regulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "down regulation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "down regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "down regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "down regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "down-regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "down-regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "down-regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "downregulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "downregulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "downregulation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "downregulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "downregulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "downregulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "inhibition of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "inhibition of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "inhibition of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "inhibition of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "inhibition of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "inhibition of transcription from RNA polymerase II promoter involved in heart development" NARROW [GOC:TermGenie] synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "negative regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "negative regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "negative regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "negative regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "negative regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "negative regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "negative regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "negative regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:1901213 ! regulation of transcription from RNA polymerase II promoter involved in heart development intersection_of: GO:0000122 ! negative regulation of transcription by RNA polymerase II intersection_of: part_of GO:0007507 ! heart development created_by: pr creation_date: 2012-08-07T12:50:30Z [Term] id: GO:1901228 name: positive regulation of transcription from RNA polymerase II promoter involved in heart development namespace: biological_process def: "Any positive regulation of transcription from RNA polymerase II promoter that is involved in heart development." [GOC:BHF, GOC:TermGenie] synonym: "activation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "activation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "activation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter involved in heart development" NARROW [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "positive regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter involved in heart development" NARROW [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:1901213 ! regulation of transcription from RNA polymerase II promoter involved in heart development intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: part_of GO:0007507 ! heart development created_by: pr creation_date: 2012-08-07T12:53:01Z [Term] id: GO:1901232 name: regulation of convergent extension involved in axis elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of convergent extension involved in axis elongation." [GOC:BHF, GOC:TermGenie] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:1905330 ! regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0060028 ! convergent extension involved in axis elongation relationship: regulates GO:0060028 ! convergent extension involved in axis elongation created_by: vk creation_date: 2012-08-07T14:21:46Z [Term] id: GO:1901233 name: negative regulation of convergent extension involved in axis elongation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in axis elongation." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of convergent extension involved in axis elongation" EXACT [GOC:TermGenie] synonym: "down-regulation of convergent extension involved in axis elongation" EXACT [GOC:TermGenie] synonym: "downregulation of convergent extension involved in axis elongation" EXACT [GOC:TermGenie] synonym: "inhibition of convergent extension involved in axis elongation" NARROW [GOC:TermGenie] is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:1901232 ! regulation of convergent extension involved in axis elongation is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0060028 ! convergent extension involved in axis elongation relationship: negatively_regulates GO:0060028 ! convergent extension involved in axis elongation created_by: vk creation_date: 2012-08-07T14:22:11Z [Term] id: GO:1901234 name: positive regulation of convergent extension involved in axis elongation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of convergent extension involved in axis elongation." [GOC:BHF, GOC:TermGenie] synonym: "activation of convergent extension involved in axis elongation" NARROW [GOC:TermGenie] synonym: "up regulation of convergent extension involved in axis elongation" EXACT [GOC:TermGenie] synonym: "up-regulation of convergent extension involved in axis elongation" EXACT [GOC:TermGenie] synonym: "upregulation of convergent extension involved in axis elongation" EXACT [GOC:TermGenie] is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:1901232 ! regulation of convergent extension involved in axis elongation is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0060028 ! convergent extension involved in axis elongation relationship: positively_regulates GO:0060028 ! convergent extension involved in axis elongation created_by: vk creation_date: 2012-08-07T14:22:19Z [Term] id: GO:1901360 name: organic cyclic compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic cyclic compound." [GOC:TermGenie] synonym: "organic cyclic compound metabolism" EXACT [GOC:TermGenie] is_a: GO:0071704 ! organic substance metabolic process created_by: bf creation_date: 2012-09-14T09:03:51Z [Term] id: GO:1901362 name: organic cyclic compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of organic cyclic compound." [GOC:TermGenie] synonym: "organic cyclic compound anabolism" EXACT [GOC:TermGenie] synonym: "organic cyclic compound biosynthesis" EXACT [GOC:TermGenie] synonym: "organic cyclic compound formation" EXACT [GOC:TermGenie] synonym: "organic cyclic compound synthesis" EXACT [GOC:TermGenie] is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901576 ! organic substance biosynthetic process created_by: bf creation_date: 2012-09-14T09:05:22Z [Term] id: GO:1901407 name: regulation of phosphorylation of RNA polymerase II C-terminal domain namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain." [GOC:TermGenie] synonym: "regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain relationship: regulates GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain created_by: vw creation_date: 2012-10-01T14:39:50Z [Term] id: GO:1901408 name: negative regulation of phosphorylation of RNA polymerase II C-terminal domain namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain." [GOC:TermGenie] synonym: "down regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "down regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "down regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "down regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] synonym: "down regulation of phosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] synonym: "down-regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "down-regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "down-regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "down-regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] synonym: "downregulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "downregulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "downregulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "downregulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] synonym: "downregulation of phosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] synonym: "inhibition of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "inhibition of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "inhibition of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "inhibition of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] synonym: "inhibition of phosphorylation of RNA polymerase II C-terminal domain" NARROW [GOC:TermGenie] synonym: "negative regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "negative regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "negative regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "negative regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] is_a: GO:0001933 ! negative regulation of protein phosphorylation is_a: GO:1901407 ! regulation of phosphorylation of RNA polymerase II C-terminal domain intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain relationship: negatively_regulates GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain created_by: vw creation_date: 2012-10-01T14:40:58Z [Term] id: GO:1901409 name: positive regulation of phosphorylation of RNA polymerase II C-terminal domain namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain." [GOC:TermGenie] synonym: "activation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "activation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "activation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "activation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] synonym: "activation of phosphorylation of RNA polymerase II C-terminal domain" NARROW [GOC:TermGenie] synonym: "positive regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "positive regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "positive regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "positive regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] synonym: "up regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "up regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "up regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "up regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] synonym: "up regulation of phosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] synonym: "up-regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "up-regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "up-regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "up-regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] synonym: "upregulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "upregulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "upregulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "upregulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] synonym: "upregulation of phosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] is_a: GO:0001934 ! positive regulation of protein phosphorylation is_a: GO:1901407 ! regulation of phosphorylation of RNA polymerase II C-terminal domain intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain relationship: positively_regulates GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain created_by: vw creation_date: 2012-10-01T14:41:15Z [Term] id: GO:1901522 name: positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus namespace: biological_process def: "Any positive regulation of transcription from RNA polymerase II promoter that is involved in cellular response to chemical stimulus." [GOC:TermGenie, PMID:22840777] synonym: "activation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" NARROW [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" NARROW [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: part_of GO:0070887 ! cellular response to chemical stimulus relationship: part_of GO:0070887 ! cellular response to chemical stimulus created_by: al creation_date: 2012-10-19T08:25:05Z [Term] id: GO:1901564 name: organonitrogen compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organonitrogen compound." [GOC:pr, GOC:TermGenie] synonym: "organonitrogen compound metabolism" EXACT [GOC:TermGenie] is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0071704 ! organic substance metabolic process created_by: pr creation_date: 2012-11-04T15:17:52Z [Term] id: GO:1901576 name: organic substance biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon." [GOC:pr, GOC:TermGenie] synonym: "organic molecular entity anabolism" EXACT [GOC:TermGenie] synonym: "organic molecular entity biosynthesis" EXACT [GOC:TermGenie] synonym: "organic molecular entity biosynthetic process" EXACT [] synonym: "organic molecular entity formation" EXACT [GOC:TermGenie] synonym: "organic molecular entity synthesis" EXACT [GOC:TermGenie] synonym: "organic substance anabolism" EXACT [] synonym: "organic substance biosynthesis" EXACT [] synonym: "organic substance formation" EXACT [] synonym: "organic substance synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0071704 ! organic substance metabolic process created_by: pr creation_date: 2012-11-05T11:04:40Z [Term] id: GO:1901615 name: organic hydroxy compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic hydroxy compound." [GOC:pr, GOC:TermGenie] synonym: "organic hydroxy compound metabolism" EXACT [GOC:TermGenie] is_a: GO:0071704 ! organic substance metabolic process created_by: pr creation_date: 2012-11-13T12:54:27Z [Term] id: GO:1901652 name: response to peptide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound created_by: pr creation_date: 2012-11-20T09:45:15Z [Term] id: GO:1901653 name: cellular response to peptide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie] is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901652 ! response to peptide is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: pr creation_date: 2012-11-20T09:45:19Z [Term] id: GO:1901673 name: regulation of mitotic spindle assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic spindle assembly." [GOC:TermGenie] synonym: "regulation of spindle assembly involved in mitosis" EXACT [] is_a: GO:0060236 ! regulation of mitotic spindle organization is_a: GO:0090169 ! regulation of spindle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0090307 ! mitotic spindle assembly relationship: regulates GO:0090307 ! mitotic spindle assembly created_by: al creation_date: 2012-11-22T09:50:00Z [Term] id: GO:1901698 name: response to nitrogen compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] synonym: "response to nitrogen molecular entity" EXACT [] is_a: GO:0042221 ! response to chemical created_by: pr creation_date: 2012-12-13T15:06:08Z [Term] id: GO:1901699 name: cellular response to nitrogen compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] synonym: "cellular response to nitrogen molecular entity" EXACT [] is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:1901698 ! response to nitrogen compound created_by: pr creation_date: 2012-12-13T15:06:13Z [Term] id: GO:1901700 name: response to oxygen-containing compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] synonym: "response to oxygen molecular entity" EXACT [] is_a: GO:0042221 ! response to chemical created_by: pr creation_date: 2012-12-13T15:11:37Z [Term] id: GO:1901701 name: cellular response to oxygen-containing compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] synonym: "cellular response to oxygen molecular entity" EXACT [] is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:1901700 ! response to oxygen-containing compound created_by: pr creation_date: 2012-12-13T15:11:42Z [Term] id: GO:1901983 name: regulation of protein acetylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein acetylation." [GOC:TermGenie, PMID:22117195] synonym: "regulation of protein amino acid acetylation" EXACT [GOC:TermGenie] is_a: GO:0031399 ! regulation of protein modification process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006473 ! protein acetylation relationship: regulates GO:0006473 ! protein acetylation created_by: ss creation_date: 2013-03-14T00:40:07Z [Term] id: GO:1901984 name: negative regulation of protein acetylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein acetylation." [GOC:TermGenie, PMID:22117195] synonym: "down regulation of protein acetylation" EXACT [GOC:TermGenie] synonym: "down regulation of protein amino acid acetylation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein acetylation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein amino acid acetylation" EXACT [GOC:TermGenie] synonym: "downregulation of protein acetylation" EXACT [GOC:TermGenie] synonym: "downregulation of protein amino acid acetylation" EXACT [GOC:TermGenie] synonym: "inhibition of protein acetylation" NARROW [GOC:TermGenie] synonym: "inhibition of protein amino acid acetylation" NARROW [GOC:TermGenie] synonym: "negative regulation of protein amino acid acetylation" EXACT [GOC:TermGenie] is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:1901983 ! regulation of protein acetylation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006473 ! protein acetylation relationship: negatively_regulates GO:0006473 ! protein acetylation created_by: ss creation_date: 2013-03-14T00:40:11Z [Term] id: GO:1901985 name: positive regulation of protein acetylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein acetylation." [GOC:TermGenie, PMID:22117195] synonym: "activation of protein acetylation" NARROW [GOC:TermGenie] synonym: "activation of protein amino acid acetylation" NARROW [GOC:TermGenie] synonym: "positive regulation of protein amino acid acetylation" EXACT [GOC:TermGenie] synonym: "up regulation of protein acetylation" EXACT [GOC:TermGenie] synonym: "up regulation of protein amino acid acetylation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein acetylation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein amino acid acetylation" EXACT [GOC:TermGenie] synonym: "upregulation of protein acetylation" EXACT [GOC:TermGenie] synonym: "upregulation of protein amino acid acetylation" EXACT [GOC:TermGenie] is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:1901983 ! regulation of protein acetylation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006473 ! protein acetylation relationship: positively_regulates GO:0006473 ! protein acetylation created_by: ss creation_date: 2013-03-14T00:40:19Z [Term] id: GO:1902017 name: regulation of cilium assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cilium assembly." [GOC:cilia, GOC:dph, GOC:TermGenie, PMID:17719545] synonym: "regulation of ciliogenesis" EXACT [GOC:TermGenie] synonym: "regulation of cilium biogenesis" RELATED [GOC:TermGenie] is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0060271 ! cilium assembly relationship: regulates GO:0060271 ! cilium assembly created_by: dph creation_date: 2013-03-26T18:10:51Z [Term] id: GO:1902018 name: negative regulation of cilium assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly." [GOC:cilia, GOC:dph, GOC:TermGenie, PMID:17719545] synonym: "down regulation of ciliogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of cilium assembly" EXACT [GOC:TermGenie] synonym: "down regulation of cilium biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of ciliogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of cilium assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of cilium biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of ciliogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of cilium assembly" EXACT [GOC:TermGenie] synonym: "downregulation of cilium biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of ciliogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of cilium assembly" NARROW [GOC:TermGenie] synonym: "inhibition of cilium biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of ciliogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of cilium biogenesis" RELATED [GOC:TermGenie] is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly is_a: GO:1902017 ! regulation of cilium assembly is_a: GO:1902116 ! negative regulation of organelle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0060271 ! cilium assembly relationship: negatively_regulates GO:0060271 ! cilium assembly created_by: dph creation_date: 2013-03-26T18:10:56Z [Term] id: GO:1902064 name: regulation of transcription from RNA polymerase II promoter involved in spermatogenesis namespace: biological_process def: "Any regulation of transcription from RNA polymerase II promoter that is involved in spermatogenesis." [GOC:kmv, GOC:TermGenie, PMID:22570621] synonym: "global transcription regulation from Pol II promoter involved in generation of spermatozoa" RELATED [GOC:TermGenie] synonym: "global transcription regulation from Pol II promoter involved in spermatogenesis" RELATED [GOC:TermGenie] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in generation of spermatozoa" RELATED [GOC:TermGenie] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in spermatogenesis" RELATED [GOC:TermGenie] synonym: "regulation of global transcription from Pol II promoter involved in generation of spermatozoa" RELATED [GOC:TermGenie] synonym: "regulation of global transcription from Pol II promoter involved in spermatogenesis" RELATED [GOC:TermGenie] synonym: "regulation of transcription from Pol II promoter involved in generation of spermatozoa" EXACT [GOC:TermGenie] synonym: "regulation of transcription from Pol II promoter involved in spermatogenesis" EXACT [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter involved in generation of spermatozoa" EXACT [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter, global involved in generation of spermatozoa" RELATED [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter, global involved in spermatogenesis" RELATED [GOC:TermGenie] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0022414 ! reproductive process intersection_of: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: part_of GO:0007283 ! spermatogenesis relationship: part_of GO:0007283 ! spermatogenesis created_by: kmv creation_date: 2013-04-16T20:27:18Z [Term] id: GO:1902115 name: regulation of organelle assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0044087 ! regulation of cellular component biogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0070925 ! organelle assembly relationship: regulates GO:0070925 ! organelle assembly created_by: pr creation_date: 2013-05-14T09:43:21Z [Term] id: GO:1902116 name: negative regulation of organelle assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie] synonym: "down regulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "downregulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "inhibition of organelle assembly" NARROW [GOC:TermGenie] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0070925 ! organelle assembly relationship: negatively_regulates GO:0070925 ! organelle assembly created_by: pr creation_date: 2013-05-14T09:43:31Z [Term] id: GO:1902117 name: positive regulation of organelle assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie] synonym: "activation of organelle assembly" NARROW [GOC:TermGenie] synonym: "up regulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "upregulation of organelle assembly" EXACT [GOC:TermGenie] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0070925 ! organelle assembly relationship: positively_regulates GO:0070925 ! organelle assembly created_by: pr creation_date: 2013-05-14T09:43:36Z [Term] id: GO:1902275 name: regulation of chromatin organization namespace: biological_process alt_id: GO:1903308 def: "Any process that modulates the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:bf, GOC:TermGenie, GOC:vw, PMID:18314879] synonym: "regulation of chromatin modification" RELATED [] synonym: "regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006325 ! chromatin organization relationship: regulates GO:0006325 ! chromatin organization created_by: bf creation_date: 2013-07-01T13:21:52Z [Term] id: GO:1902284 name: neuron projection extension involved in neuron projection guidance namespace: biological_process def: "Any neuron projection extension that is involved in neuron projection guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22790009] synonym: "neurite extension involved in neurite guidance" NARROW [GOC:TermGenie] synonym: "neurite extension involved in neuron process guidance" NARROW [GOC:TermGenie] synonym: "neurite extension involved in neuron projection guidance" NARROW [GOC:TermGenie] synonym: "neurite extension involved in neuron protrusion guidance" NARROW [GOC:TermGenie] synonym: "neurite extension involved in neuronal cell projection guidance" NARROW [GOC:TermGenie] synonym: "neuron process extension involved in neurite guidance" NARROW [GOC:TermGenie] synonym: "neuron process extension involved in neuron process guidance" EXACT [GOC:TermGenie] synonym: "neuron process extension involved in neuron projection guidance" EXACT [GOC:TermGenie] synonym: "neuron process extension involved in neuron protrusion guidance" EXACT [GOC:TermGenie] synonym: "neuron process extension involved in neuronal cell projection guidance" EXACT [GOC:TermGenie] synonym: "neuron projection extension involved in neurite guidance" NARROW [GOC:TermGenie] synonym: "neuron projection extension involved in neuron process guidance" EXACT [GOC:TermGenie] synonym: "neuron projection extension involved in neuron protrusion guidance" EXACT [GOC:TermGenie] synonym: "neuron projection extension involved in neuronal cell projection guidance" EXACT [GOC:TermGenie] synonym: "neuron protrusion extension involved in neurite guidance" NARROW [GOC:TermGenie] synonym: "neuron protrusion extension involved in neuron process guidance" EXACT [GOC:TermGenie] synonym: "neuron protrusion extension involved in neuron projection guidance" EXACT [GOC:TermGenie] synonym: "neuron protrusion extension involved in neuron protrusion guidance" EXACT [GOC:TermGenie] synonym: "neuron protrusion extension involved in neuronal cell projection guidance" EXACT [GOC:TermGenie] synonym: "neuronal cell projection extension involved in neurite guidance" NARROW [GOC:TermGenie] synonym: "neuronal cell projection extension involved in neuron process guidance" EXACT [GOC:TermGenie] synonym: "neuronal cell projection extension involved in neuron projection guidance" EXACT [GOC:TermGenie] synonym: "neuronal cell projection extension involved in neuron protrusion guidance" EXACT [GOC:TermGenie] synonym: "neuronal cell projection extension involved in neuronal cell projection guidance" EXACT [GOC:TermGenie] is_a: GO:1990138 ! neuron projection extension intersection_of: GO:1990138 ! neuron projection extension intersection_of: part_of GO:0097485 ! neuron projection guidance relationship: part_of GO:0097485 ! neuron projection guidance created_by: pr creation_date: 2013-07-08T15:55:17Z [Term] id: GO:1902337 name: regulation of apoptotic process involved in morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035] synonym: "regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] is_a: GO:1904748 ! regulation of apoptotic process involved in development intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0060561 ! apoptotic process involved in morphogenesis relationship: regulates GO:0060561 ! apoptotic process involved in morphogenesis created_by: sart creation_date: 2013-07-29T15:03:16Z [Term] id: GO:1902338 name: negative regulation of apoptotic process involved in morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035] synonym: "down regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "down regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "down-regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "down-regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "downregulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "downregulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "inhibition of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "inhibition of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "negative regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "negative regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "negative regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis is_a: GO:1904746 ! negative regulation of apoptotic process involved in development intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0060561 ! apoptotic process involved in morphogenesis relationship: negatively_regulates GO:0060561 ! apoptotic process involved in morphogenesis created_by: sart creation_date: 2013-07-29T15:03:25Z [Term] id: GO:1902339 name: positive regulation of apoptotic process involved in morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035] synonym: "activation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "activation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "positive regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "positive regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "positive regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "up regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "up regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "up-regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "up-regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "upregulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "upregulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis is_a: GO:1904747 ! positive regulation of apoptotic process involved in development intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0060561 ! apoptotic process involved in morphogenesis relationship: positively_regulates GO:0060561 ! apoptotic process involved in morphogenesis created_by: sart creation_date: 2013-07-29T15:03:33Z [Term] id: GO:1902412 name: regulation of mitotic cytokinesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic cytokinesis." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie] is_a: GO:0032465 ! regulation of cytokinesis intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0000281 ! mitotic cytokinesis relationship: regulates GO:0000281 ! mitotic cytokinesis created_by: jl creation_date: 2013-09-12T14:11:49Z [Term] id: GO:1902413 name: negative regulation of mitotic cytokinesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cytokinesis." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "down regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie] synonym: "down regulation of mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "down-regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "downregulation of cytokinesis after mitosis" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "inhibition of cytokinesis after mitosis" NARROW [GOC:TermGenie] synonym: "inhibition of mitotic cytokinesis" NARROW [GOC:TermGenie] synonym: "negative regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie] is_a: GO:0032466 ! negative regulation of cytokinesis is_a: GO:1902412 ! regulation of mitotic cytokinesis intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0000281 ! mitotic cytokinesis relationship: negatively_regulates GO:0000281 ! mitotic cytokinesis created_by: jl creation_date: 2013-09-12T14:11:59Z [Term] id: GO:1902531 name: regulation of intracellular signal transduction namespace: biological_process alt_id: GO:0010627 def: "Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] synonym: "regulation of intracellular protein kinase cascade" NARROW [] synonym: "regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "regulation of intracellular signaling cascade" EXACT [GOC:TermGenie] synonym: "regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0035556 ! intracellular signal transduction relationship: regulates GO:0035556 ! intracellular signal transduction created_by: bf creation_date: 2013-12-02T11:32:52Z [Term] id: GO:1902532 name: negative regulation of intracellular signal transduction namespace: biological_process alt_id: GO:0010741 def: "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] synonym: "down regulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "down regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "down regulation of intracellular signaling cascade" NARROW [GOC:TermGenie] synonym: "down regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "down regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "down regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "down regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "down-regulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "down-regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "down-regulation of intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "down-regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "down-regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "down-regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "down-regulation of signal transmission via intracellular cascade" RELATED [GOC:TermGenie] synonym: "downregulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "downregulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "downregulation of intracellular signaling cascade" NARROW [GOC:TermGenie] synonym: "downregulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "downregulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "downregulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "downregulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular signal transduction" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular signaling cascade" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular signaling chain" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "inhibition of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "inhibition of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "negative regulation of intracellular protein kinase cascade" EXACT [] synonym: "negative regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of intracellular signaling cascade" EXACT [GOC:TermGenie] synonym: "negative regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "negative regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "negative regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0035556 ! intracellular signal transduction relationship: negatively_regulates GO:0035556 ! intracellular signal transduction created_by: bf creation_date: 2013-12-02T11:33:01Z [Term] id: GO:1902533 name: positive regulation of intracellular signal transduction namespace: biological_process alt_id: GO:0010740 def: "Any process that activates or increases the frequency, rate or extent of intracellular signal transduction." [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] synonym: "activation of intracellular signal transduction" NARROW [GOC:TermGenie] synonym: "activation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "activation of intracellular signaling cascade" NARROW [GOC:TermGenie] synonym: "activation of intracellular signaling chain" NARROW [GOC:TermGenie] synonym: "activation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "activation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "activation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "positive regulation of intracellular protein kinase cascade" NARROW [] synonym: "positive regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "positive regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "positive regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "positive regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "positive regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "up regulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "up regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "up regulation of intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "up regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "up regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "up regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "up regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "up-regulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "up-regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "up-regulation of intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "up-regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "up-regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "up-regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "up-regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "upregulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "upregulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "upregulation of intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "upregulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "upregulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "upregulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "upregulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0035556 ! intracellular signal transduction relationship: positively_regulates GO:0035556 ! intracellular signal transduction created_by: bf creation_date: 2013-12-02T11:33:10Z [Term] id: GO:1902667 name: regulation of axon guidance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of axon guidance." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23006775] synonym: "regulation of axon chemotaxis" RELATED [GOC:TermGenie] synonym: "regulation of axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "regulation of axon pathfinding" EXACT [GOC:TermGenie] is_a: GO:0050920 ! regulation of chemotaxis is_a: GO:0051270 ! regulation of cellular component movement intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007411 ! axon guidance relationship: regulates GO:0007411 ! axon guidance created_by: hjd creation_date: 2014-01-31T18:50:10Z [Term] id: GO:1902668 name: negative regulation of axon guidance namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of axon guidance." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23006775] synonym: "down regulation of axon chemotaxis" RELATED [GOC:TermGenie] synonym: "down regulation of axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "down regulation of axon guidance" EXACT [GOC:TermGenie] synonym: "down regulation of axon pathfinding" EXACT [GOC:TermGenie] synonym: "down-regulation of axon chemotaxis" RELATED [GOC:TermGenie] synonym: "down-regulation of axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "down-regulation of axon guidance" EXACT [GOC:TermGenie] synonym: "down-regulation of axon pathfinding" EXACT [GOC:TermGenie] synonym: "downregulation of axon chemotaxis" RELATED [GOC:TermGenie] synonym: "downregulation of axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "downregulation of axon guidance" EXACT [GOC:TermGenie] synonym: "downregulation of axon pathfinding" EXACT [GOC:TermGenie] synonym: "inhibition of axon chemotaxis" RELATED [GOC:TermGenie] synonym: "inhibition of axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "inhibition of axon guidance" NARROW [GOC:TermGenie] synonym: "inhibition of axon pathfinding" NARROW [GOC:TermGenie] synonym: "negative regulation of axon chemotaxis" RELATED [GOC:TermGenie] synonym: "negative regulation of axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "negative regulation of axon pathfinding" EXACT [GOC:TermGenie] is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:0051271 ! negative regulation of cellular component movement is_a: GO:1902667 ! regulation of axon guidance intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007411 ! axon guidance relationship: negatively_regulates GO:0007411 ! axon guidance created_by: hjd creation_date: 2014-01-31T18:50:19Z [Term] id: GO:1902669 name: positive regulation of axon guidance namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of axon guidance." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23006775] synonym: "activation of axon chemotaxis" RELATED [GOC:TermGenie] synonym: "activation of axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "activation of axon guidance" NARROW [GOC:TermGenie] synonym: "activation of axon pathfinding" NARROW [GOC:TermGenie] synonym: "positive regulation of axon chemotaxis" RELATED [GOC:TermGenie] synonym: "positive regulation of axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "positive regulation of axon pathfinding" EXACT [GOC:TermGenie] synonym: "up regulation of axon chemotaxis" RELATED [GOC:TermGenie] synonym: "up regulation of axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "up regulation of axon guidance" EXACT [GOC:TermGenie] synonym: "up regulation of axon pathfinding" EXACT [GOC:TermGenie] synonym: "up-regulation of axon chemotaxis" RELATED [GOC:TermGenie] synonym: "up-regulation of axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "up-regulation of axon guidance" EXACT [GOC:TermGenie] synonym: "up-regulation of axon pathfinding" EXACT [GOC:TermGenie] synonym: "upregulation of axon chemotaxis" RELATED [GOC:TermGenie] synonym: "upregulation of axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "upregulation of axon guidance" EXACT [GOC:TermGenie] synonym: "upregulation of axon pathfinding" EXACT [GOC:TermGenie] is_a: GO:0051272 ! positive regulation of cellular component movement is_a: GO:1902667 ! regulation of axon guidance intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007411 ! axon guidance relationship: positively_regulates GO:0007411 ! axon guidance created_by: hjd creation_date: 2014-01-31T18:50:29Z [Term] id: GO:1902679 name: negative regulation of RNA biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] synonym: "down regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "down regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of RNA formation" EXACT [GOC:TermGenie] synonym: "downregulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of RNA anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of RNA biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of RNA biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of RNA formation" NARROW [GOC:TermGenie] synonym: "inhibition of RNA synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA synthesis" EXACT [GOC:TermGenie] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051253 ! negative regulation of RNA metabolic process is_a: GO:2001141 ! regulation of RNA biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0032774 ! RNA biosynthetic process relationship: negatively_regulates GO:0032774 ! RNA biosynthetic process created_by: jl creation_date: 2014-02-05T16:32:01Z [Term] id: GO:1902680 name: positive regulation of RNA biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] synonym: "activation of RNA anabolism" NARROW [GOC:TermGenie] synonym: "activation of RNA biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of RNA biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of RNA formation" NARROW [GOC:TermGenie] synonym: "activation of RNA synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "up regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of RNA formation" EXACT [GOC:TermGenie] synonym: "upregulation of RNA synthesis" EXACT [GOC:TermGenie] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0051254 ! positive regulation of RNA metabolic process is_a: GO:2001141 ! regulation of RNA biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0032774 ! RNA biosynthetic process relationship: positively_regulates GO:0032774 ! RNA biosynthetic process created_by: jl creation_date: 2014-02-05T16:32:10Z [Term] id: GO:1902742 name: apoptotic process involved in development namespace: biological_process def: "Any apoptotic process that is involved in anatomical structure development." [GO_REF:0000060, GOC:mtg_apoptosis, GOC:pg, GOC:TermGenie] synonym: "activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "apoptotic process involved in anatomical structure development" EXACT [] synonym: "apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0048856 ! anatomical structure development relationship: part_of GO:0048856 ! anatomical structure development created_by: pr creation_date: 2014-02-28T13:09:43Z [Term] id: GO:1902850 name: microtubule cytoskeleton organization involved in mitosis namespace: biological_process def: "Any microtubule cytoskeleton organization that is involved in mitosis." [GO_REF:0000060, GOC:TermGenie, PMID:18799626] synonym: "microtubule cytoskeleton organisation involved in mitosis" EXACT [GOC:TermGenie] synonym: "microtubule cytoskeleton organization and biogenesis involved in mitosis" RELATED [GOC:TermGenie] synonym: "microtubule dynamics involved in mitosis" EXACT [GOC:TermGenie] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0000226 ! microtubule cytoskeleton organization intersection_of: part_of GO:0000278 ! mitotic cell cycle created_by: vw creation_date: 2014-04-02T14:19:38Z [Term] id: GO:1902903 name: regulation of supramolecular fiber organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] comment: HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro synonym: "regulation of fibril organisation" RELATED [GOC:TermGenie] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0097435 ! supramolecular fiber organization relationship: regulates GO:0097435 ! supramolecular fiber organization created_by: rl creation_date: 2014-04-15T16:46:36Z [Term] id: GO:1902904 name: negative regulation of supramolecular fiber organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] comment: HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro synonym: "down regulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "down regulation of fibril organization" RELATED [GOC:TermGenie] synonym: "down-regulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "down-regulation of fibril organization" RELATED [GOC:TermGenie] synonym: "downregulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "downregulation of fibril organization" RELATED [GOC:TermGenie] synonym: "inhibition of fibril organisation" NARROW [GOC:TermGenie] synonym: "inhibition of fibril organization" NARROW [GOC:TermGenie] synonym: "negative regulation of fibril organisation" RELATED [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0097435 ! supramolecular fiber organization relationship: negatively_regulates GO:0097435 ! supramolecular fiber organization created_by: rl creation_date: 2014-04-15T16:46:42Z [Term] id: GO:1902905 name: positive regulation of supramolecular fiber organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] comment: HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro synonym: "activation of fibril organisation" NARROW [GOC:TermGenie] synonym: "activation of fibril organization" NARROW [GOC:TermGenie] synonym: "positive regulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "up regulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "up regulation of fibril organization" RELATED [GOC:TermGenie] synonym: "up-regulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "up-regulation of fibril organization" RELATED [GOC:TermGenie] synonym: "upregulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "upregulation of fibril organization" RELATED [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0097435 ! supramolecular fiber organization relationship: positively_regulates GO:0097435 ! supramolecular fiber organization created_by: rl creation_date: 2014-04-15T16:46:48Z [Term] id: GO:1903008 name: organelle disassembly namespace: biological_process def: "The disaggregation of an organelle into its constituent components." [GO_REF:0000079, GOC:TermGenie] synonym: "organelle degradation" EXACT [] is_a: GO:0006996 ! organelle organization is_a: GO:0022411 ! cellular component disassembly created_by: jl creation_date: 2014-05-13T12:36:03Z [Term] id: GO:1903034 name: regulation of response to wounding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to wounding." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:19164535] synonym: "regulation of physiological response to wounding" EXACT [GOC:TermGenie] is_a: GO:0080134 ! regulation of response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009611 ! response to wounding relationship: regulates GO:0009611 ! response to wounding created_by: kmv creation_date: 2014-05-18T01:28:46Z [Term] id: GO:1903035 name: negative regulation of response to wounding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to wounding." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:19164535] synonym: "down regulation of physiological response to wounding" EXACT [GOC:TermGenie] synonym: "down regulation of response to wounding" EXACT [GOC:TermGenie] synonym: "down-regulation of physiological response to wounding" EXACT [GOC:TermGenie] synonym: "down-regulation of response to wounding" EXACT [GOC:TermGenie] synonym: "downregulation of physiological response to wounding" EXACT [GOC:TermGenie] synonym: "downregulation of response to wounding" EXACT [GOC:TermGenie] synonym: "inhibition of physiological response to wounding" NARROW [GOC:TermGenie] synonym: "inhibition of response to wounding" NARROW [GOC:TermGenie] synonym: "negative regulation of physiological response to wounding" EXACT [GOC:TermGenie] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1903034 ! regulation of response to wounding intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009611 ! response to wounding relationship: negatively_regulates GO:0009611 ! response to wounding created_by: kmv creation_date: 2014-05-18T01:28:52Z [Term] id: GO:1903036 name: positive regulation of response to wounding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to wounding." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:19164535] synonym: "activation of physiological response to wounding" NARROW [GOC:TermGenie] synonym: "activation of response to wounding" NARROW [GOC:TermGenie] synonym: "positive regulation of physiological response to wounding" EXACT [GOC:TermGenie] synonym: "up regulation of physiological response to wounding" EXACT [GOC:TermGenie] synonym: "up regulation of response to wounding" EXACT [GOC:TermGenie] synonym: "up-regulation of physiological response to wounding" EXACT [GOC:TermGenie] synonym: "up-regulation of response to wounding" EXACT [GOC:TermGenie] synonym: "upregulation of physiological response to wounding" EXACT [GOC:TermGenie] synonym: "upregulation of response to wounding" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1903034 ! regulation of response to wounding intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009611 ! response to wounding relationship: positively_regulates GO:0009611 ! response to wounding created_by: kmv creation_date: 2014-05-18T01:28:58Z [Term] id: GO:1903046 name: meiotic cell cycle process namespace: biological_process def: "A process that is part of the meiotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] subset: gocheck_do_not_annotate subset: goslim_pombe is_a: GO:0022402 ! cell cycle process is_a: GO:0022414 ! reproductive process intersection_of: GO:0009987 ! cellular process intersection_of: part_of GO:0051321 ! meiotic cell cycle disjoint_from: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0051321 ! meiotic cell cycle created_by: jl creation_date: 2014-05-22T14:22:28Z [Term] id: GO:1903047 name: mitotic cell cycle process namespace: biological_process def: "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] subset: gocheck_do_not_annotate is_a: GO:0022402 ! cell cycle process intersection_of: GO:0009987 ! cellular process intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000278 ! mitotic cell cycle created_by: jl creation_date: 2014-05-22T14:22:34Z [Term] id: GO:1903115 name: regulation of actin filament-based movement namespace: biological_process def: "Any process that modulates the frequency, rate or extent of actin filament-based movement." [GO_REF:0000058, GOC:TermGenie, PMID:24798735] is_a: GO:0032970 ! regulation of actin filament-based process is_a: GO:0051270 ! regulation of cellular component movement intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0030048 ! actin filament-based movement relationship: regulates GO:0030048 ! actin filament-based movement created_by: al creation_date: 2014-06-12T16:55:57Z [Term] id: GO:1903116 name: positive regulation of actin filament-based movement namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of actin filament-based movement." [GO_REF:0000058, GOC:TermGenie, PMID:24798735] synonym: "activation of actin filament-based movement" NARROW [GOC:TermGenie] synonym: "up regulation of actin filament-based movement" EXACT [GOC:TermGenie] synonym: "up-regulation of actin filament-based movement" EXACT [GOC:TermGenie] synonym: "upregulation of actin filament-based movement" EXACT [GOC:TermGenie] is_a: GO:0051272 ! positive regulation of cellular component movement is_a: GO:1903115 ! regulation of actin filament-based movement intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0030048 ! actin filament-based movement relationship: positively_regulates GO:0030048 ! actin filament-based movement created_by: al creation_date: 2014-06-12T16:56:04Z [Term] id: GO:1903332 name: regulation of protein folding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein folding." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "regulation of alpha-tubulin folding" NARROW [GOC:TermGenie] synonym: "regulation of beta-tubulin folding" NARROW [GOC:TermGenie] synonym: "regulation of chaperone activity" RELATED [GOC:TermGenie] synonym: "regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie] synonym: "regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] synonym: "regulation of co-chaperone activity" RELATED [GOC:TermGenie] synonym: "regulation of co-chaperonin activity" RELATED [GOC:TermGenie] synonym: "regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] synonym: "regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] synonym: "regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006457 ! protein folding relationship: regulates GO:0006457 ! protein folding created_by: vw creation_date: 2014-08-18T13:14:34Z [Term] id: GO:1903333 name: negative regulation of protein folding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein folding." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "down regulation of alpha-tubulin folding" NARROW [GOC:TermGenie] synonym: "down regulation of beta-tubulin folding" NARROW [GOC:TermGenie] synonym: "down regulation of chaperone activity" RELATED [GOC:TermGenie] synonym: "down regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie] synonym: "down regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] synonym: "down regulation of co-chaperone activity" RELATED [GOC:TermGenie] synonym: "down regulation of co-chaperonin activity" RELATED [GOC:TermGenie] synonym: "down regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] synonym: "down regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] synonym: "down regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] synonym: "down regulation of protein folding" EXACT [GOC:TermGenie] synonym: "down-regulation of alpha-tubulin folding" NARROW [GOC:TermGenie] synonym: "down-regulation of beta-tubulin folding" NARROW [GOC:TermGenie] synonym: "down-regulation of chaperone activity" RELATED [GOC:TermGenie] synonym: "down-regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie] synonym: "down-regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] synonym: "down-regulation of co-chaperone activity" RELATED [GOC:TermGenie] synonym: "down-regulation of co-chaperonin activity" RELATED [GOC:TermGenie] synonym: "down-regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] synonym: "down-regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] synonym: "down-regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] synonym: "down-regulation of protein folding" EXACT [GOC:TermGenie] synonym: "downregulation of alpha-tubulin folding" NARROW [GOC:TermGenie] synonym: "downregulation of beta-tubulin folding" NARROW [GOC:TermGenie] synonym: "downregulation of chaperone activity" RELATED [GOC:TermGenie] synonym: "downregulation of chaperonin ATPase activity" RELATED [GOC:TermGenie] synonym: "downregulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] synonym: "downregulation of co-chaperone activity" RELATED [GOC:TermGenie] synonym: "downregulation of co-chaperonin activity" RELATED [GOC:TermGenie] synonym: "downregulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] synonym: "downregulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] synonym: "downregulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] synonym: "downregulation of protein folding" EXACT [GOC:TermGenie] synonym: "inhibition of alpha-tubulin folding" NARROW [GOC:TermGenie] synonym: "inhibition of beta-tubulin folding" NARROW [GOC:TermGenie] synonym: "inhibition of chaperone activity" RELATED [GOC:TermGenie] synonym: "inhibition of chaperonin ATPase activity" RELATED [GOC:TermGenie] synonym: "inhibition of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] synonym: "inhibition of co-chaperone activity" RELATED [GOC:TermGenie] synonym: "inhibition of co-chaperonin activity" RELATED [GOC:TermGenie] synonym: "inhibition of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] synonym: "inhibition of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] synonym: "inhibition of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] synonym: "inhibition of protein folding" NARROW [GOC:TermGenie] synonym: "negative regulation of alpha-tubulin folding" NARROW [GOC:TermGenie] synonym: "negative regulation of beta-tubulin folding" NARROW [GOC:TermGenie] synonym: "negative regulation of chaperone activity" RELATED [GOC:TermGenie] synonym: "negative regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie] synonym: "negative regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] synonym: "negative regulation of co-chaperone activity" RELATED [GOC:TermGenie] synonym: "negative regulation of co-chaperonin activity" RELATED [GOC:TermGenie] synonym: "negative regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] synonym: "negative regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] synonym: "negative regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1903332 ! regulation of protein folding intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006457 ! protein folding relationship: negatively_regulates GO:0006457 ! protein folding created_by: vw creation_date: 2014-08-18T13:14:42Z [Term] id: GO:1903334 name: positive regulation of protein folding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein folding." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "activation of alpha-tubulin folding" NARROW [GOC:TermGenie] synonym: "activation of beta-tubulin folding" NARROW [GOC:TermGenie] synonym: "activation of chaperone activity" RELATED [GOC:TermGenie] synonym: "activation of chaperonin ATPase activity" RELATED [GOC:TermGenie] synonym: "activation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] synonym: "activation of co-chaperone activity" RELATED [GOC:TermGenie] synonym: "activation of co-chaperonin activity" RELATED [GOC:TermGenie] synonym: "activation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] synonym: "activation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] synonym: "activation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] synonym: "activation of protein folding" NARROW [GOC:TermGenie] synonym: "positive regulation of alpha-tubulin folding" NARROW [GOC:TermGenie] synonym: "positive regulation of beta-tubulin folding" NARROW [GOC:TermGenie] synonym: "positive regulation of chaperone activity" RELATED [GOC:TermGenie] synonym: "positive regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie] synonym: "positive regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] synonym: "positive regulation of co-chaperone activity" RELATED [GOC:TermGenie] synonym: "positive regulation of co-chaperonin activity" RELATED [GOC:TermGenie] synonym: "positive regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] synonym: "positive regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] synonym: "positive regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] synonym: "up regulation of alpha-tubulin folding" NARROW [GOC:TermGenie] synonym: "up regulation of beta-tubulin folding" NARROW [GOC:TermGenie] synonym: "up regulation of chaperone activity" RELATED [GOC:TermGenie] synonym: "up regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie] synonym: "up regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] synonym: "up regulation of co-chaperone activity" RELATED [GOC:TermGenie] synonym: "up regulation of co-chaperonin activity" RELATED [GOC:TermGenie] synonym: "up regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] synonym: "up regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] synonym: "up regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] synonym: "up regulation of protein folding" EXACT [GOC:TermGenie] synonym: "up-regulation of alpha-tubulin folding" NARROW [GOC:TermGenie] synonym: "up-regulation of beta-tubulin folding" NARROW [GOC:TermGenie] synonym: "up-regulation of chaperone activity" RELATED [GOC:TermGenie] synonym: "up-regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie] synonym: "up-regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] synonym: "up-regulation of co-chaperone activity" RELATED [GOC:TermGenie] synonym: "up-regulation of co-chaperonin activity" RELATED [GOC:TermGenie] synonym: "up-regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] synonym: "up-regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] synonym: "up-regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] synonym: "up-regulation of protein folding" EXACT [GOC:TermGenie] synonym: "upregulation of alpha-tubulin folding" NARROW [GOC:TermGenie] synonym: "upregulation of beta-tubulin folding" NARROW [GOC:TermGenie] synonym: "upregulation of chaperone activity" RELATED [GOC:TermGenie] synonym: "upregulation of chaperonin ATPase activity" RELATED [GOC:TermGenie] synonym: "upregulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] synonym: "upregulation of co-chaperone activity" RELATED [GOC:TermGenie] synonym: "upregulation of co-chaperonin activity" RELATED [GOC:TermGenie] synonym: "upregulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] synonym: "upregulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] synonym: "upregulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] synonym: "upregulation of protein folding" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1903332 ! regulation of protein folding intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006457 ! protein folding relationship: positively_regulates GO:0006457 ! protein folding created_by: vw creation_date: 2014-08-18T13:14:50Z [Term] id: GO:1903490 name: positive regulation of mitotic cytokinesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic cytokinesis." [GO_REF:0000058, GOC:TermGenie, PMID:24920823] synonym: "activation of cytokinesis after mitosis" NARROW [GOC:TermGenie] synonym: "activation of mitotic cytokinesis" NARROW [GOC:TermGenie] synonym: "positive regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie] synonym: "up regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "up-regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "upregulation of cytokinesis after mitosis" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic cytokinesis" EXACT [GOC:TermGenie] is_a: GO:0032467 ! positive regulation of cytokinesis is_a: GO:1902412 ! regulation of mitotic cytokinesis intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0000281 ! mitotic cytokinesis relationship: positively_regulates GO:0000281 ! mitotic cytokinesis created_by: al creation_date: 2014-09-25T09:00:35Z [Term] id: GO:1903506 name: regulation of nucleic acid-templated transcription namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nucleic acid-templated transcription." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:txnOH, GOC:vw] is_a: GO:2001141 ! regulation of RNA biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0097659 ! nucleic acid-templated transcription relationship: regulates GO:0097659 ! nucleic acid-templated transcription created_by: pr creation_date: 2014-10-01T14:44:47Z [Term] id: GO:1903507 name: negative regulation of nucleic acid-templated transcription namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of nucleic acid-templated transcription." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:txnOH, GOC:vw] synonym: "down regulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie] synonym: "down-regulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie] synonym: "downregulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie] synonym: "inhibition of nucleic acid-templated transcription" NARROW [GOC:TermGenie] is_a: GO:1902679 ! negative regulation of RNA biosynthetic process is_a: GO:1903506 ! regulation of nucleic acid-templated transcription intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0097659 ! nucleic acid-templated transcription relationship: negatively_regulates GO:0097659 ! nucleic acid-templated transcription created_by: pr creation_date: 2014-10-01T14:44:56Z [Term] id: GO:1903508 name: positive regulation of nucleic acid-templated transcription namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nucleic acid-templated transcription." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:txnOH, GOC:vw] synonym: "activation of nucleic acid-templated transcription" NARROW [GOC:TermGenie] synonym: "up regulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie] synonym: "up-regulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie] synonym: "upregulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie] is_a: GO:1902680 ! positive regulation of RNA biosynthetic process is_a: GO:1903506 ! regulation of nucleic acid-templated transcription intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0097659 ! nucleic acid-templated transcription relationship: positively_regulates GO:0097659 ! nucleic acid-templated transcription created_by: pr creation_date: 2014-10-01T14:45:04Z [Term] id: GO:1903522 name: regulation of blood circulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969] synonym: "regulation of hemolymph circulation" RELATED [GOC:TermGenie] is_a: GO:0044057 ! regulation of system process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0008015 ! blood circulation relationship: regulates GO:0008015 ! blood circulation created_by: mr creation_date: 2014-10-06T18:38:56Z [Term] id: GO:1903523 name: negative regulation of blood circulation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969] synonym: "down regulation of blood circulation" EXACT [GOC:TermGenie] synonym: "down regulation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "down-regulation of blood circulation" EXACT [GOC:TermGenie] synonym: "down-regulation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "downregulation of blood circulation" EXACT [GOC:TermGenie] synonym: "downregulation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "inhibition of blood circulation" NARROW [GOC:TermGenie] synonym: "inhibition of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "negative regulation of hemolymph circulation" RELATED [GOC:TermGenie] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1903522 ! regulation of blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0008015 ! blood circulation relationship: negatively_regulates GO:0008015 ! blood circulation created_by: mr creation_date: 2014-10-06T18:39:05Z [Term] id: GO:1903524 name: positive regulation of blood circulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969] synonym: "activation of blood circulation" NARROW [GOC:TermGenie] synonym: "activation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "positive regulation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "up regulation of blood circulation" EXACT [GOC:TermGenie] synonym: "up regulation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "up-regulation of blood circulation" EXACT [GOC:TermGenie] synonym: "up-regulation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "upregulation of blood circulation" EXACT [GOC:TermGenie] synonym: "upregulation of hemolymph circulation" RELATED [GOC:TermGenie] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1903522 ! regulation of blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0008015 ! blood circulation relationship: positively_regulates GO:0008015 ! blood circulation created_by: mr creation_date: 2014-10-06T18:39:13Z [Term] id: GO:1903564 name: regulation of protein localization to cilium namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0061512 ! protein localization to cilium relationship: regulates GO:0061512 ! protein localization to cilium created_by: krc creation_date: 2014-10-24T20:58:11Z [Term] id: GO:1903565 name: negative regulation of protein localization to cilium namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] synonym: "down regulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "inhibition of protein localization to cilium" NARROW [GOC:TermGenie] is_a: GO:1903564 ! regulation of protein localization to cilium is_a: GO:1903828 ! negative regulation of cellular protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0061512 ! protein localization to cilium relationship: negatively_regulates GO:0061512 ! protein localization to cilium created_by: krc creation_date: 2014-10-24T20:58:20Z [Term] id: GO:1903566 name: positive regulation of protein localization to cilium namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] synonym: "activation of protein localization to cilium" NARROW [GOC:TermGenie] synonym: "up regulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to cilium" EXACT [GOC:TermGenie] is_a: GO:1903564 ! regulation of protein localization to cilium is_a: GO:1903829 ! positive regulation of cellular protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0061512 ! protein localization to cilium relationship: positively_regulates GO:0061512 ! protein localization to cilium created_by: krc creation_date: 2014-10-24T20:58:28Z [Term] id: GO:1903616 name: MAPK cascade involved in axon regeneration namespace: biological_process def: "Any MAPK cascade that is involved in axon regeneration." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:19164707, PMID:19417215, PMID:19737525] synonym: "ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] is_a: GO:0000165 ! MAPK cascade intersection_of: GO:0000165 ! MAPK cascade intersection_of: part_of GO:0031103 ! axon regeneration relationship: part_of GO:0031103 ! axon regeneration created_by: kmv creation_date: 2014-11-18T19:11:59Z [Term] id: GO:1903792 name: negative regulation of anion transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of anion transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802] synonym: "down regulation of anion transport" EXACT [GOC:TermGenie] synonym: "down-regulation of anion transport" EXACT [GOC:TermGenie] synonym: "downregulation of anion transport" EXACT [GOC:TermGenie] synonym: "inhibition of anion transport" NARROW [GOC:TermGenie] is_a: GO:0043271 ! negative regulation of ion transport is_a: GO:0044070 ! regulation of anion transport intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006820 ! anion transport relationship: negatively_regulates GO:0006820 ! anion transport created_by: sl creation_date: 2015-01-12T21:50:20Z [Term] id: GO:1903793 name: positive regulation of anion transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of anion transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802] synonym: "activation of anion transport" NARROW [GOC:TermGenie] synonym: "up regulation of anion transport" EXACT [GOC:TermGenie] synonym: "up-regulation of anion transport" EXACT [GOC:TermGenie] synonym: "upregulation of anion transport" EXACT [GOC:TermGenie] is_a: GO:0043270 ! positive regulation of ion transport is_a: GO:0044070 ! regulation of anion transport intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006820 ! anion transport relationship: positively_regulates GO:0006820 ! anion transport created_by: sl creation_date: 2015-01-12T21:50:30Z [Term] id: GO:1903827 name: regulation of cellular protein localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "regulation of channel localizer activity" NARROW [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0034613 ! cellular protein localization relationship: regulates GO:0034613 ! cellular protein localization created_by: jl creation_date: 2015-01-20T14:32:14Z [Term] id: GO:1903828 name: negative regulation of cellular protein localization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "down regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "down regulation of channel localizer activity" NARROW [GOC:TermGenie] synonym: "down-regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "down-regulation of channel localizer activity" NARROW [GOC:TermGenie] synonym: "downregulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "downregulation of channel localizer activity" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein localisation" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein localization" NARROW [GOC:TermGenie] synonym: "inhibition of channel localizer activity" NARROW [GOC:TermGenie] synonym: "negative regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "negative regulation of channel localizer activity" NARROW [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0034613 ! cellular protein localization relationship: negatively_regulates GO:0034613 ! cellular protein localization created_by: jl creation_date: 2015-01-20T14:32:24Z [Term] id: GO:1903829 name: positive regulation of cellular protein localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "activation of cellular protein localisation" NARROW [GOC:TermGenie] synonym: "activation of cellular protein localization" NARROW [GOC:TermGenie] synonym: "activation of channel localizer activity" NARROW [GOC:TermGenie] synonym: "positive regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "positive regulation of channel localizer activity" NARROW [GOC:TermGenie] synonym: "up regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "up regulation of channel localizer activity" NARROW [GOC:TermGenie] synonym: "up-regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "up-regulation of channel localizer activity" NARROW [GOC:TermGenie] synonym: "upregulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "upregulation of channel localizer activity" NARROW [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0034613 ! cellular protein localization relationship: positively_regulates GO:0034613 ! cellular protein localization created_by: jl creation_date: 2015-01-20T14:32:33Z [Term] id: GO:1904081 name: positive regulation of transcription from RNA polymerase II promoter involved in neuron differentiation namespace: biological_process def: "Any positive regulation of transcription from RNA polymerase II promoter that is involved in neuron differentiation." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:24353061] synonym: "activation of global transcription from RNA polymerase II promoter involved in neuron differentiation" RELATED [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter involved in neuron differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in neuron differentiation" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter involved in neuron differentiation" RELATED [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter involved in neuron differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from RNA polymerase II promoter, global involved in neuron differentiation" RELATED [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter involved in neuron differentiation" NARROW [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter involved in neuron differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter involved in neuron differentiation" RELATED [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter involved in neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in neuron differentiation" RELATED [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter involved in neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter involved in neuron differentiation" RELATED [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter involved in neuron differentiation" EXACT [GOC:TermGenie] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: part_of GO:0030182 ! neuron differentiation relationship: part_of GO:0030182 ! neuron differentiation created_by: kmv creation_date: 2015-03-24T20:15:59Z [Term] id: GO:1904103 name: regulation of convergent extension involved in gastrulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of convergent extension involved in gastrulation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] is_a: GO:1905330 ! regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0060027 ! convergent extension involved in gastrulation relationship: regulates GO:0060027 ! convergent extension involved in gastrulation created_by: dph creation_date: 2015-04-01T11:17:05Z [Term] id: GO:1904104 name: negative regulation of convergent extension involved in gastrulation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in gastrulation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] synonym: "down regulation of convergent extension involved in gastrulation" EXACT [GOC:TermGenie] synonym: "down-regulation of convergent extension involved in gastrulation" EXACT [GOC:TermGenie] synonym: "downregulation of convergent extension involved in gastrulation" EXACT [GOC:TermGenie] synonym: "inhibition of convergent extension involved in gastrulation" NARROW [GOC:TermGenie] is_a: GO:1904103 ! regulation of convergent extension involved in gastrulation is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0060027 ! convergent extension involved in gastrulation relationship: negatively_regulates GO:0060027 ! convergent extension involved in gastrulation created_by: dph creation_date: 2015-04-01T11:17:12Z [Term] id: GO:1904105 name: positive regulation of convergent extension involved in gastrulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of convergent extension involved in gastrulation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] synonym: "activation of convergent extension involved in gastrulation" NARROW [GOC:TermGenie] synonym: "up regulation of convergent extension involved in gastrulation" EXACT [GOC:TermGenie] synonym: "up-regulation of convergent extension involved in gastrulation" EXACT [GOC:TermGenie] synonym: "upregulation of convergent extension involved in gastrulation" EXACT [GOC:TermGenie] is_a: GO:1904103 ! regulation of convergent extension involved in gastrulation is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0060027 ! convergent extension involved in gastrulation relationship: positively_regulates GO:0060027 ! convergent extension involved in gastrulation created_by: dph creation_date: 2015-04-01T11:17:18Z [Term] id: GO:1904126 name: convergent extension involved in notochord morphogenesis namespace: biological_process def: "Any convergent extension that is involved in notochord morphogenesis." [GO_REF:0000060, GOC:dph, GOC:TermGenie, PMID:24892953] is_a: GO:0060027 ! convergent extension involved in gastrulation is_a: GO:0060029 ! convergent extension involved in organogenesis intersection_of: GO:0060026 ! convergent extension intersection_of: part_of GO:0048570 ! notochord morphogenesis relationship: part_of GO:0048570 ! notochord morphogenesis created_by: dph creation_date: 2015-04-10T21:12:57Z [Term] id: GO:1904127 name: regulation of convergent extension involved in somitogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of convergent extension involved in somitogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] is_a: GO:1901232 ! regulation of convergent extension involved in axis elongation is_a: GO:1904103 ! regulation of convergent extension involved in gastrulation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0090246 ! convergent extension involved in somitogenesis relationship: regulates GO:0090246 ! convergent extension involved in somitogenesis created_by: dph creation_date: 2015-04-10T21:13:04Z [Term] id: GO:1904128 name: negative regulation of convergent extension involved in somitogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in somitogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] synonym: "down regulation of convergent extension involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of convergent extension involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of convergent extension involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of convergent extension involved in somitogenesis" NARROW [GOC:TermGenie] is_a: GO:1901233 ! negative regulation of convergent extension involved in axis elongation is_a: GO:1904104 ! negative regulation of convergent extension involved in gastrulation is_a: GO:1904127 ! regulation of convergent extension involved in somitogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0090246 ! convergent extension involved in somitogenesis relationship: negatively_regulates GO:0090246 ! convergent extension involved in somitogenesis created_by: dph creation_date: 2015-04-10T21:13:10Z [Term] id: GO:1904129 name: positive regulation of convergent extension involved in somitogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of convergent extension involved in somitogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] synonym: "activation of convergent extension involved in somitogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of convergent extension involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of convergent extension involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of convergent extension involved in somitogenesis" EXACT [GOC:TermGenie] is_a: GO:1901234 ! positive regulation of convergent extension involved in axis elongation is_a: GO:1904105 ! positive regulation of convergent extension involved in gastrulation is_a: GO:1904127 ! regulation of convergent extension involved in somitogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0090246 ! convergent extension involved in somitogenesis relationship: positively_regulates GO:0090246 ! convergent extension involved in somitogenesis created_by: dph creation_date: 2015-04-10T21:13:15Z [Term] id: GO:1904130 name: regulation of convergent extension involved in neural plate elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of convergent extension involved in neural plate elongation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] is_a: GO:1904103 ! regulation of convergent extension involved in gastrulation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0022007 ! convergent extension involved in neural plate elongation relationship: regulates GO:0022007 ! convergent extension involved in neural plate elongation created_by: dph creation_date: 2015-04-10T21:13:21Z [Term] id: GO:1904131 name: negative regulation of convergent extension involved in neural plate elongation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in neural plate elongation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] synonym: "down regulation of convergent extension involved in neural plate elongation" EXACT [GOC:TermGenie] synonym: "down-regulation of convergent extension involved in neural plate elongation" EXACT [GOC:TermGenie] synonym: "downregulation of convergent extension involved in neural plate elongation" EXACT [GOC:TermGenie] synonym: "inhibition of convergent extension involved in neural plate elongation" NARROW [GOC:TermGenie] is_a: GO:1904104 ! negative regulation of convergent extension involved in gastrulation is_a: GO:1904130 ! regulation of convergent extension involved in neural plate elongation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0022007 ! convergent extension involved in neural plate elongation relationship: negatively_regulates GO:0022007 ! convergent extension involved in neural plate elongation created_by: dph creation_date: 2015-04-10T21:13:27Z [Term] id: GO:1904132 name: positive regulation of convergent extension involved in neural plate elongation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of convergent extension involved in neural plate elongation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] synonym: "activation of convergent extension involved in neural plate elongation" NARROW [GOC:TermGenie] synonym: "up regulation of convergent extension involved in neural plate elongation" EXACT [GOC:TermGenie] synonym: "up-regulation of convergent extension involved in neural plate elongation" EXACT [GOC:TermGenie] synonym: "upregulation of convergent extension involved in neural plate elongation" EXACT [GOC:TermGenie] is_a: GO:1904105 ! positive regulation of convergent extension involved in gastrulation is_a: GO:1904130 ! regulation of convergent extension involved in neural plate elongation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0022007 ! convergent extension involved in neural plate elongation relationship: positively_regulates GO:0022007 ! convergent extension involved in neural plate elongation created_by: dph creation_date: 2015-04-10T21:13:33Z [Term] id: GO:1904136 name: regulation of convergent extension involved in notochord morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of convergent extension involved in notochord morphogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] is_a: GO:1904103 ! regulation of convergent extension involved in gastrulation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:1904126 ! convergent extension involved in notochord morphogenesis relationship: regulates GO:1904126 ! convergent extension involved in notochord morphogenesis created_by: dph creation_date: 2015-04-10T21:21:30Z [Term] id: GO:1904137 name: negative regulation of convergent extension involved in notochord morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in notochord morphogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] synonym: "down regulation of convergent extension involved in notochord morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of convergent extension involved in notochord morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of convergent extension involved in notochord morphogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of convergent extension involved in notochord morphogenesis" NARROW [GOC:TermGenie] is_a: GO:1904104 ! negative regulation of convergent extension involved in gastrulation is_a: GO:1904136 ! regulation of convergent extension involved in notochord morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:1904126 ! convergent extension involved in notochord morphogenesis relationship: negatively_regulates GO:1904126 ! convergent extension involved in notochord morphogenesis created_by: dph creation_date: 2015-04-10T21:21:36Z [Term] id: GO:1904138 name: positive regulation of convergent extension involved in notochord morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of convergent extension involved in notochord morphogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] synonym: "activation of convergent extension involved in notochord morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of convergent extension involved in notochord morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of convergent extension involved in notochord morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of convergent extension involved in notochord morphogenesis" EXACT [GOC:TermGenie] is_a: GO:1904105 ! positive regulation of convergent extension involved in gastrulation is_a: GO:1904136 ! regulation of convergent extension involved in notochord morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:1904126 ! convergent extension involved in notochord morphogenesis relationship: positively_regulates GO:1904126 ! convergent extension involved in notochord morphogenesis created_by: dph creation_date: 2015-04-10T21:21:41Z [Term] id: GO:1904746 name: negative regulation of apoptotic process involved in development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495] comment: U4PR86 in PMID:22801495 inferred from mutant phenotype synonym: "down regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down-regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down-regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down-regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down-regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down-regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down-regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down-regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down-regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down-regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down-regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down-regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down-regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down-regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down-regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down-regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "downregulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "downregulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "downregulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "downregulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "downregulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "downregulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "downregulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "downregulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "downregulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "downregulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "downregulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "downregulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "downregulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "downregulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "downregulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "downregulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "downregulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "downregulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "downregulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "downregulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "inhibition of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "inhibition of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "inhibition of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "inhibition of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "inhibition of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "inhibition of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "inhibition of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "inhibition of programmed cell death by apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of programmed cell death by apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "inhibition of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "inhibition of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "negative regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "negative regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "negative regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "negative regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "negative regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "negative regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "negative regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "negative regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "negative regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "negative regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "negative regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "negative regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "negative regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "negative regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "negative regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "negative regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1904748 ! regulation of apoptotic process involved in development intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:1902742 ! apoptotic process involved in development relationship: negatively_regulates GO:1902742 ! apoptotic process involved in development created_by: es creation_date: 2015-10-19T14:12:27Z [Term] id: GO:1904747 name: positive regulation of apoptotic process involved in development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495] comment: U4PR86 in PMID:22801495 inferred from mutant phenotype synonym: "activation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "activation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptotic cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process involved in development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptotic programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "activation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "activation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "activation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "activation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "activation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "activation of programmed cell death by apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of programmed cell death by apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "activation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "activation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "positive regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "positive regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "positive regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "positive regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "positive regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "positive regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "positive regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "positive regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "positive regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "positive regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "positive regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "positive regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "positive regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "positive regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "positive regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "positive regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up-regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up-regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up-regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up-regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up-regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up-regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up-regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up-regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up-regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up-regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up-regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up-regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up-regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up-regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up-regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "upregulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "upregulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "upregulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "upregulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "upregulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "upregulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "upregulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "upregulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "upregulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "upregulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "upregulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "upregulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "upregulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "upregulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "upregulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "upregulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "upregulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "upregulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "upregulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "upregulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1904748 ! regulation of apoptotic process involved in development intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:1902742 ! apoptotic process involved in development relationship: positively_regulates GO:1902742 ! apoptotic process involved in development created_by: es creation_date: 2015-10-19T14:12:34Z [Term] id: GO:1904748 name: regulation of apoptotic process involved in development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495] comment: Q10943 in PMID:22801495, inferred from mutant phenotype synonym: "regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] is_a: GO:0042981 ! regulation of apoptotic process is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:1902742 ! apoptotic process involved in development relationship: regulates GO:1902742 ! apoptotic process involved in development created_by: es creation_date: 2015-10-19T15:02:28Z [Term] id: GO:1904920 name: regulation of MAPK cascade involved in axon regeneration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of MAPK cascade involved in axon regeneration." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:20203177] synonym: "regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] is_a: GO:0043408 ! regulation of MAPK cascade intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:1903616 ! MAPK cascade involved in axon regeneration relationship: regulates GO:1903616 ! MAPK cascade involved in axon regeneration created_by: kmv creation_date: 2016-01-25T17:03:35Z [Term] id: GO:1904921 name: negative regulation of MAPK cascade involved in axon regeneration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of MAPK cascade involved in axon regeneration." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:20203177] synonym: "down regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "down regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "down regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "down regulation of MAPK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "down regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "down regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "down regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "down regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "down regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "down regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "down-regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "down-regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "down-regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "down-regulation of MAPK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "down-regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "down-regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "down-regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "down-regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "down-regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "down-regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "downregulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "downregulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "downregulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "downregulation of MAPK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "downregulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "downregulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "downregulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "downregulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "downregulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "downregulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "inhibition of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "inhibition of MAP kinase cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "inhibition of MAP kinase kinase kinase cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "inhibition of MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "inhibition of MAPK signal transduction involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "inhibition of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "inhibition of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "inhibition of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "inhibition of MAPKKK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "inhibition of mitogen-activated protein kinase cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "negative regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "negative regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "negative regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "negative regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "negative regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "negative regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "negative regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "negative regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "negative regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] is_a: GO:0043409 ! negative regulation of MAPK cascade is_a: GO:1904920 ! regulation of MAPK cascade involved in axon regeneration intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:1903616 ! MAPK cascade involved in axon regeneration relationship: negatively_regulates GO:1903616 ! MAPK cascade involved in axon regeneration created_by: kmv creation_date: 2016-01-25T17:03:42Z [Term] id: GO:1904922 name: positive regulation of MAPK cascade involved in axon regeneration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of MAPK cascade involved in axon regeneration." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:20203177] synonym: "activation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "activation of MAP kinase cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "activation of MAP kinase kinase kinase cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "activation of MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "activation of MAPK signal transduction involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "activation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "activation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "activation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "activation of MAPKKK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "activation of mitogen-activated protein kinase cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "positive regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "positive regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "positive regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "positive regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "positive regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "positive regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "positive regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "positive regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "positive regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "up regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "up regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "up regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "up regulation of MAPK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "up regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "up regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "up regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "up regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "up regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "up regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "up-regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "up-regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "up-regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "up-regulation of MAPK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "up-regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "up-regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "up-regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "up-regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "up-regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "up-regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "upregulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "upregulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "upregulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "upregulation of MAPK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "upregulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "upregulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "upregulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "upregulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "upregulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "upregulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] is_a: GO:0043410 ! positive regulation of MAPK cascade is_a: GO:1904920 ! regulation of MAPK cascade involved in axon regeneration intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:1903616 ! MAPK cascade involved in axon regeneration relationship: positively_regulates GO:1903616 ! MAPK cascade involved in axon regeneration created_by: kmv creation_date: 2016-01-25T17:03:49Z [Term] id: GO:1904938 name: planar cell polarity pathway involved in axon guidance namespace: biological_process def: "Any Wnt signaling pathway, planar cell polarity pathway that is involved in axon guidance." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21106844, PMID:23517308] synonym: "non-canonical Wnt signaling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] synonym: "non-canonical Wnt signaling pathway involved in axon growth cone guidance" RELATED [GOC:TermGenie] synonym: "non-canonical Wnt signaling pathway involved in axon guidance" RELATED [GOC:TermGenie] synonym: "non-canonical Wnt signaling pathway involved in axon pathfinding" RELATED [GOC:TermGenie] synonym: "PCP pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] synonym: "PCP pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "PCP pathway involved in axon guidance" EXACT [GOC:TermGenie] synonym: "PCP pathway involved in axon pathfinding" EXACT [GOC:TermGenie] synonym: "planar cell polarity pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] synonym: "planar cell polarity pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "planar cell polarity pathway involved in axon guidance" EXACT [GOC:TermGenie] synonym: "planar cell polarity pathway involved in axon pathfinding" EXACT [GOC:TermGenie] synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in axon guidance" EXACT [GOC:TermGenie] synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in axon pathfinding" EXACT [GOC:TermGenie] synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in axon guidance" EXACT [GOC:TermGenie] synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in axon pathfinding" EXACT [GOC:TermGenie] synonym: "Wnt signaling pathway, planar cell polarity pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] synonym: "Wnt signaling pathway, planar cell polarity pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "Wnt signaling pathway, planar cell polarity pathway involved in axon guidance" EXACT [GOC:bf] synonym: "Wnt signaling pathway, planar cell polarity pathway involved in axon pathfinding" EXACT [GOC:TermGenie] synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in axon guidance" EXACT [GOC:TermGenie] synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in axon pathfinding" EXACT [GOC:TermGenie] synonym: "Wnt-JNK signaling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] synonym: "Wnt-JNK signaling pathway involved in axon growth cone guidance" RELATED [GOC:TermGenie] synonym: "Wnt-JNK signaling pathway involved in axon guidance" RELATED [GOC:TermGenie] synonym: "Wnt-JNK signaling pathway involved in axon pathfinding" RELATED [GOC:TermGenie] synonym: "Wnt-PCP signaling involved in axon guidance" EXACT [GOC:bf] synonym: "Wnt-PCP signaling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] synonym: "Wnt-PCP signaling pathway involved in axon growth cone guidance" RELATED [GOC:TermGenie] synonym: "Wnt-PCP signaling pathway involved in axon guidance" RELATED [GOC:TermGenie] synonym: "Wnt-PCP signaling pathway involved in axon pathfinding" RELATED [GOC:TermGenie] is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway intersection_of: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway intersection_of: part_of GO:0007411 ! axon guidance relationship: part_of GO:0007411 ! axon guidance created_by: bf creation_date: 2016-02-02T14:46:26Z [Term] id: GO:1904950 name: negative regulation of establishment of protein localization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445] synonym: "down regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "down regulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "down regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "down regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "down-regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "down-regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "downregulation of protein positioning" EXACT [GOC:TermGenie] synonym: "downregulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "inhibition of establishment of protein localisation" NARROW [GOC:TermGenie] synonym: "inhibition of establishment of protein localization" NARROW [GOC:TermGenie] synonym: "inhibition of protein positioning" NARROW [GOC:TermGenie] synonym: "inhibition of protein recruitment" NARROW [GOC:TermGenie] synonym: "negative regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "negative regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "negative regulation of protein recruitment" EXACT [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0070201 ! regulation of establishment of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0045184 ! establishment of protein localization relationship: negatively_regulates GO:0045184 ! establishment of protein localization created_by: mec creation_date: 2016-02-05T09:59:24Z [Term] id: GO:1904951 name: positive regulation of establishment of protein localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445] synonym: "activation of establishment of protein localisation" NARROW [GOC:TermGenie] synonym: "activation of establishment of protein localization" NARROW [GOC:TermGenie] synonym: "activation of protein positioning" NARROW [GOC:TermGenie] synonym: "activation of protein recruitment" NARROW [GOC:TermGenie] synonym: "positive regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "positive regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "positive regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "up regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "up regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "up-regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "up-regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "upregulation of protein positioning" EXACT [GOC:TermGenie] synonym: "upregulation of protein recruitment" EXACT [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0070201 ! regulation of establishment of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0045184 ! establishment of protein localization relationship: positively_regulates GO:0045184 ! establishment of protein localization created_by: mec creation_date: 2016-02-05T09:59:32Z [Term] id: GO:1905066 name: regulation of canonical Wnt signaling pathway involved in heart development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of canonical Wnt signaling pathway involved in heart development." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25034767] synonym: "regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie] is_a: GO:0003307 ! regulation of Wnt signaling pathway involved in heart development is_a: GO:0060828 ! regulation of canonical Wnt signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0061316 ! canonical Wnt signaling pathway involved in heart development relationship: regulates GO:0061316 ! canonical Wnt signaling pathway involved in heart development created_by: bc creation_date: 2016-03-21T12:46:56Z [Term] id: GO:1905067 name: negative regulation of canonical Wnt signaling pathway involved in heart development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of canonical Wnt signaling pathway involved in heart development." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25034767] synonym: "down regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "down regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "down regulation of canonical Wnt signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "down regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "down-regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "down-regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "down-regulation of canonical Wnt signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "down-regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "downregulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "downregulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "downregulation of canonical Wnt signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "downregulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "inhibition of canonical Wnt receptor signaling pathway involved in heart development" NARROW [GOC:TermGenie] synonym: "inhibition of canonical Wnt receptor signalling pathway involved in heart development" NARROW [GOC:TermGenie] synonym: "inhibition of canonical Wnt signaling pathway involved in heart development" NARROW [GOC:TermGenie] synonym: "inhibition of canonical Wnt-activated signaling pathway involved in heart development" NARROW [GOC:TermGenie] synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "negative regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie] is_a: GO:0003308 ! negative regulation of Wnt signaling pathway involved in heart development is_a: GO:0090090 ! negative regulation of canonical Wnt signaling pathway is_a: GO:1905066 ! regulation of canonical Wnt signaling pathway involved in heart development intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0061316 ! canonical Wnt signaling pathway involved in heart development relationship: negatively_regulates GO:0061316 ! canonical Wnt signaling pathway involved in heart development created_by: bc creation_date: 2016-03-21T12:47:06Z [Term] id: GO:1905068 name: positive regulation of canonical Wnt signaling pathway involved in heart development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of canonical Wnt signaling pathway involved in heart development." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25034767] synonym: "activation of canonical Wnt receptor signaling pathway involved in heart development" NARROW [GOC:TermGenie] synonym: "activation of canonical Wnt receptor signalling pathway involved in heart development" NARROW [GOC:TermGenie] synonym: "activation of canonical Wnt signaling pathway involved in heart development" NARROW [GOC:TermGenie] synonym: "activation of canonical Wnt-activated signaling pathway involved in heart development" NARROW [GOC:TermGenie] synonym: "positive regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "positive regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "positive regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "up regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "up regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "up regulation of canonical Wnt signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "up regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "up-regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "up-regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "up-regulation of canonical Wnt signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "up-regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "upregulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "upregulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "upregulation of canonical Wnt signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "upregulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0090263 ! positive regulation of canonical Wnt signaling pathway is_a: GO:1905066 ! regulation of canonical Wnt signaling pathway involved in heart development intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0061316 ! canonical Wnt signaling pathway involved in heart development relationship: positively_regulates GO:0061316 ! canonical Wnt signaling pathway involved in heart development created_by: bc creation_date: 2016-03-21T12:47:15Z [Term] id: GO:1905114 name: cell surface receptor signaling pathway involved in cell-cell signaling namespace: biological_process def: "Any cell surface receptor signaling pathway that is involved in cell-cell signaling." [GO_REF:0000060, GOC:TermGenie, ISBN:0-7167-3051-0] synonym: "cell surface receptor linked signal transduction involved in cell-cell signaling" EXACT [GOC:TermGenie] synonym: "cell surface receptor linked signal transduction involved in cell-cell signalling" EXACT [GOC:TermGenie] synonym: "cell surface receptor linked signaling pathway involved in cell-cell signaling" EXACT [GOC:TermGenie] synonym: "cell surface receptor linked signaling pathway involved in cell-cell signalling" EXACT [GOC:TermGenie] synonym: "cell surface receptor linked signalling pathway involved in cell-cell signaling" EXACT [GOC:TermGenie] synonym: "cell surface receptor linked signalling pathway involved in cell-cell signalling" EXACT [GOC:TermGenie] synonym: "cell surface receptor signaling pathway involved in cell-cell signalling" EXACT [GOC:TermGenie] is_a: GO:0007166 ! cell surface receptor signaling pathway intersection_of: GO:0007166 ! cell surface receptor signaling pathway intersection_of: part_of GO:0007267 ! cell-cell signaling relationship: part_of GO:0007267 ! cell-cell signaling created_by: dos creation_date: 2016-04-06T16:59:57Z [Term] id: GO:1905268 name: negative regulation of chromatin organization namespace: biological_process alt_id: GO:1903309 def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:vw, PMID:654321] synonym: "down regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "down regulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "down regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] synonym: "down-regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] synonym: "downregulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "downregulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "downregulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] synonym: "inhibition of chromatin organisation" NARROW [GOC:TermGenie] synonym: "inhibition of chromatin organization" NARROW [GOC:TermGenie] synonym: "inhibition of establishment or maintenance of chromatin architecture" NARROW [GOC:TermGenie] synonym: "negative regulation of chromatin modification" RELATED [] synonym: "negative regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1902275 ! regulation of chromatin organization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006325 ! chromatin organization relationship: negatively_regulates GO:0006325 ! chromatin organization created_by: pr creation_date: 2016-06-15T20:14:47Z [Term] id: GO:1905269 name: positive regulation of chromatin organization namespace: biological_process alt_id: GO:1903310 def: "Any process that activates or increases the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:vw, PMID:654321] synonym: "activation of chromatin organisation" NARROW [GOC:TermGenie] synonym: "activation of chromatin organization" NARROW [GOC:TermGenie] synonym: "activation of establishment or maintenance of chromatin architecture" NARROW [GOC:TermGenie] synonym: "positive regulation of chromatin modification" RELATED [] synonym: "positive regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] synonym: "up regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "up regulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "up regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] synonym: "up-regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] synonym: "upregulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "upregulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "upregulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] is_a: GO:1902275 ! regulation of chromatin organization is_a: GO:2001252 ! positive regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006325 ! chromatin organization relationship: positively_regulates GO:0006325 ! chromatin organization created_by: pr creation_date: 2016-06-15T20:14:56Z [Term] id: GO:1905276 name: regulation of epithelial tube formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial tube formation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0072175 ! epithelial tube formation relationship: regulates GO:0072175 ! epithelial tube formation created_by: bhm creation_date: 2016-06-20T09:35:41Z [Term] id: GO:1905277 name: negative regulation of epithelial tube formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). synonym: "down regulation of epithelial tube formation" EXACT [GOC:TermGenie] synonym: "down-regulation of epithelial tube formation" EXACT [GOC:TermGenie] synonym: "downregulation of epithelial tube formation" EXACT [GOC:TermGenie] synonym: "inhibition of epithelial tube formation" NARROW [GOC:TermGenie] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905276 ! regulation of epithelial tube formation is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0072175 ! epithelial tube formation relationship: negatively_regulates GO:0072175 ! epithelial tube formation created_by: bhm creation_date: 2016-06-20T09:35:49Z [Term] id: GO:1905278 name: positive regulation of epithelial tube formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epithelial tube formation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). synonym: "activation of epithelial tube formation" NARROW [GOC:TermGenie] synonym: "up regulation of epithelial tube formation" EXACT [GOC:TermGenie] synonym: "up-regulation of epithelial tube formation" EXACT [GOC:TermGenie] synonym: "upregulation of epithelial tube formation" EXACT [GOC:TermGenie] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905276 ! regulation of epithelial tube formation is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0072175 ! epithelial tube formation relationship: positively_regulates GO:0072175 ! epithelial tube formation created_by: bhm creation_date: 2016-06-20T09:35:57Z [Term] id: GO:1905330 name: regulation of morphogenesis of an epithelium namespace: biological_process def: "Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). synonym: "regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002009 ! morphogenesis of an epithelium relationship: regulates GO:0002009 ! morphogenesis of an epithelium created_by: bhm creation_date: 2016-07-22T07:13:49Z [Term] id: GO:1905331 name: negative regulation of morphogenesis of an epithelium namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). synonym: "down regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] synonym: "down-regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] synonym: "downregulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] synonym: "inhibition of epithelium morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of morphogenesis of an epithelium" NARROW [GOC:TermGenie] synonym: "negative regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1905330 ! regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002009 ! morphogenesis of an epithelium relationship: negatively_regulates GO:0002009 ! morphogenesis of an epithelium created_by: bhm creation_date: 2016-07-22T07:13:57Z [Term] id: GO:1905332 name: positive regulation of morphogenesis of an epithelium namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). synonym: "activation of epithelium morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of morphogenesis of an epithelium" NARROW [GOC:TermGenie] synonym: "positive regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] synonym: "up-regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] synonym: "upregulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1905330 ! regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002009 ! morphogenesis of an epithelium relationship: positively_regulates GO:0002009 ! morphogenesis of an epithelium created_by: bhm creation_date: 2016-07-22T07:14:05Z [Term] id: GO:1905349 name: ciliary transition zone assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a ciliary transition zone." [GO_REF:0000079, GOC:cilia, GOC:TermGenie, PMID:21725307, PMID:23644468, PMID:24448408, PMID:26595381, PMID:26982032] synonym: "cilial transition zone assembly" EXACT [GOC:TermGenie] synonym: "cilial transition zone formation" EXACT [GOC:TermGenie] synonym: "ciliary transition zone formation" EXACT [GOC:TermGenie] synonym: "cilium transition zone assembly" EXACT [GOC:TermGenie] synonym: "cilium transition zone formation" EXACT [GOC:TermGenie] is_a: GO:0022607 ! cellular component assembly relationship: part_of GO:0060271 ! cilium assembly created_by: pr creation_date: 2016-08-04T14:49:43Z [Term] id: GO:1905427 name: intracellular signal transduction involved in positive regulation of cell growth namespace: biological_process def: "Any intracellular signal transduction that is involved in positive regulation of cell growth." [GO_REF:0000060, GOC:al, GOC:TermGenie, GOC:vw, PMID:15917811] synonym: "intracellular protein kinase cascade involved in activation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular protein kinase cascade involved in positive regulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular protein kinase cascade involved in stimulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular protein kinase cascade involved in up regulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular protein kinase cascade involved in up-regulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular protein kinase cascade involved in upregulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signal transduction involved in activation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signal transduction involved in stimulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signal transduction involved in up regulation of cell growth" EXACT [GOC:TermGenie] synonym: "intracellular signal transduction involved in up-regulation of cell growth" EXACT [GOC:TermGenie] synonym: "intracellular signal transduction involved in upregulation of cell growth" EXACT [GOC:TermGenie] synonym: "intracellular signal transduction pathway involved in activation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signal transduction pathway involved in positive regulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signal transduction pathway involved in stimulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signal transduction pathway involved in up regulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signal transduction pathway involved in up-regulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signal transduction pathway involved in upregulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signaling cascade involved in activation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling cascade involved in positive regulation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling cascade involved in stimulation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling cascade involved in up regulation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling cascade involved in up-regulation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling cascade involved in upregulation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling chain involved in activation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signaling chain involved in positive regulation of cell growth" EXACT [GOC:TermGenie] synonym: "intracellular signaling chain involved in stimulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signaling chain involved in up regulation of cell growth" EXACT [GOC:TermGenie] synonym: "intracellular signaling chain involved in up-regulation of cell growth" EXACT [GOC:TermGenie] synonym: "intracellular signaling chain involved in upregulation of cell growth" EXACT [GOC:TermGenie] synonym: "intracellular signaling pathway involved in activation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling pathway involved in positive regulation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling pathway involved in stimulation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling pathway involved in up regulation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling pathway involved in up-regulation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling pathway involved in upregulation of cell growth" RELATED [GOC:TermGenie] synonym: "protein kinase cascade involved in activation of cell growth" NARROW [GOC:TermGenie] synonym: "protein kinase cascade involved in positive regulation of cell growth" NARROW [GOC:TermGenie] synonym: "protein kinase cascade involved in stimulation of cell growth" NARROW [GOC:TermGenie] synonym: "protein kinase cascade involved in up regulation of cell growth" NARROW [GOC:TermGenie] synonym: "protein kinase cascade involved in up-regulation of cell growth" NARROW [GOC:TermGenie] synonym: "protein kinase cascade involved in upregulation of cell growth" NARROW [GOC:TermGenie] synonym: "signal transduction via intracellular signaling cascade involved in activation of cell growth" RELATED [GOC:TermGenie] synonym: "signal transduction via intracellular signaling cascade involved in positive regulation of cell growth" RELATED [GOC:TermGenie] synonym: "signal transduction via intracellular signaling cascade involved in stimulation of cell growth" RELATED [GOC:TermGenie] synonym: "signal transduction via intracellular signaling cascade involved in up regulation of cell growth" RELATED [GOC:TermGenie] synonym: "signal transduction via intracellular signaling cascade involved in up-regulation of cell growth" RELATED [GOC:TermGenie] synonym: "signal transduction via intracellular signaling cascade involved in upregulation of cell growth" RELATED [GOC:TermGenie] synonym: "signal transmission via intracellular cascade involved in activation of cell growth" NARROW [GOC:TermGenie] synonym: "signal transmission via intracellular cascade involved in positive regulation of cell growth" NARROW [GOC:TermGenie] synonym: "signal transmission via intracellular cascade involved in stimulation of cell growth" NARROW [GOC:TermGenie] synonym: "signal transmission via intracellular cascade involved in up regulation of cell growth" NARROW [GOC:TermGenie] synonym: "signal transmission via intracellular cascade involved in up-regulation of cell growth" NARROW [GOC:TermGenie] synonym: "signal transmission via intracellular cascade involved in upregulation of cell growth" NARROW [GOC:TermGenie] is_a: GO:0035556 ! intracellular signal transduction intersection_of: GO:0035556 ! intracellular signal transduction intersection_of: part_of GO:0030307 ! positive regulation of cell growth relationship: part_of GO:0030307 ! positive regulation of cell growth created_by: dph creation_date: 2016-09-07T18:15:01Z [Term] id: GO:1905516 name: positive regulation of fertilization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fertilization." [GO_REF:0000058, GOC:hbye, GOC:TermGenie, PMID:27564576] synonym: "activation of fertilization" NARROW [GOC:TermGenie] synonym: "activation of syngamy" NARROW [GOC:TermGenie] synonym: "positive regulation of syngamy" EXACT [GOC:TermGenie] synonym: "up regulation of fertilization" EXACT [GOC:TermGenie] synonym: "up regulation of syngamy" EXACT [GOC:TermGenie] synonym: "up-regulation of fertilization" EXACT [GOC:TermGenie] synonym: "up-regulation of syngamy" EXACT [GOC:TermGenie] synonym: "upregulation of fertilization" EXACT [GOC:TermGenie] synonym: "upregulation of syngamy" EXACT [GOC:TermGenie] is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0080154 ! regulation of fertilization is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009566 ! fertilization relationship: positively_regulates GO:0009566 ! fertilization created_by: pr creation_date: 2016-09-30T14:32:32Z [Term] id: GO:1905790 name: regulation of mechanosensory behavior namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mechanosensory behavior." [GO_REF:0000058, GOC:TermGenie, PMID:8692859] synonym: "regulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "regulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "regulation of mechanosensory behaviour" EXACT [GOC:TermGenie] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0050795 ! regulation of behavior intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007638 ! mechanosensory behavior relationship: regulates GO:0007638 ! mechanosensory behavior created_by: hbye creation_date: 2017-01-09T15:17:07Z [Term] id: GO:1905791 name: negative regulation of mechanosensory behavior namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mechanosensory behavior." [GO_REF:0000058, GOC:TermGenie, PMID:8692859] synonym: "down regulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "down regulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "down regulation of mechanosensory behavior" EXACT [GOC:TermGenie] synonym: "down regulation of mechanosensory behaviour" EXACT [GOC:TermGenie] synonym: "down-regulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "down-regulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "down-regulation of mechanosensory behavior" EXACT [GOC:TermGenie] synonym: "down-regulation of mechanosensory behaviour" EXACT [GOC:TermGenie] synonym: "downregulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "downregulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "downregulation of mechanosensory behavior" EXACT [GOC:TermGenie] synonym: "downregulation of mechanosensory behaviour" EXACT [GOC:TermGenie] synonym: "inhibition of behavioral response to mechanical stimulus" NARROW [GOC:TermGenie] synonym: "inhibition of behavioural response to mechanical stimulus" NARROW [GOC:TermGenie] synonym: "inhibition of mechanosensory behavior" NARROW [GOC:TermGenie] synonym: "inhibition of mechanosensory behaviour" NARROW [GOC:TermGenie] synonym: "negative regulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "negative regulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "negative regulation of mechanosensory behaviour" EXACT [GOC:TermGenie] is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0048521 ! negative regulation of behavior is_a: GO:1905790 ! regulation of mechanosensory behavior intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007638 ! mechanosensory behavior relationship: negatively_regulates GO:0007638 ! mechanosensory behavior created_by: hbye creation_date: 2017-01-09T15:17:15Z [Term] id: GO:1905792 name: positive regulation of mechanosensory behavior namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mechanosensory behavior." [GO_REF:0000058, GOC:TermGenie, PMID:8692859] synonym: "activation of behavioral response to mechanical stimulus" NARROW [GOC:TermGenie] synonym: "activation of behavioural response to mechanical stimulus" NARROW [GOC:TermGenie] synonym: "activation of mechanosensory behavior" NARROW [GOC:TermGenie] synonym: "activation of mechanosensory behaviour" NARROW [GOC:TermGenie] synonym: "positive regulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "positive regulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "positive regulation of mechanosensory behaviour" EXACT [GOC:TermGenie] synonym: "up regulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "up regulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "up regulation of mechanosensory behavior" EXACT [GOC:TermGenie] synonym: "up regulation of mechanosensory behaviour" EXACT [GOC:TermGenie] synonym: "up-regulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of mechanosensory behavior" EXACT [GOC:TermGenie] synonym: "up-regulation of mechanosensory behaviour" EXACT [GOC:TermGenie] synonym: "upregulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of mechanosensory behavior" EXACT [GOC:TermGenie] synonym: "upregulation of mechanosensory behaviour" EXACT [GOC:TermGenie] is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0048520 ! positive regulation of behavior is_a: GO:1905790 ! regulation of mechanosensory behavior intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007638 ! mechanosensory behavior relationship: positively_regulates GO:0007638 ! mechanosensory behavior created_by: hbye creation_date: 2017-01-09T15:17:24Z [Term] id: GO:1905831 name: negative regulation of spindle assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of spindle assembly." [GO_REF:0000058, GOC:TermGenie, PMID:27689799] synonym: "down regulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of bipolar spindle formation" EXACT [GOC:TermGenie] synonym: "down regulation of spindle assembly" EXACT [GOC:TermGenie] synonym: "down regulation of spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of spindle formation" EXACT [GOC:TermGenie] synonym: "down-regulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of bipolar spindle formation" EXACT [GOC:TermGenie] synonym: "down-regulation of spindle assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of spindle formation" EXACT [GOC:TermGenie] synonym: "downregulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of bipolar spindle formation" EXACT [GOC:TermGenie] synonym: "downregulation of spindle assembly" EXACT [GOC:TermGenie] synonym: "downregulation of spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of spindle formation" EXACT [GOC:TermGenie] synonym: "inhibition of bipolar spindle biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of bipolar spindle formation" NARROW [GOC:TermGenie] synonym: "inhibition of spindle assembly" NARROW [GOC:TermGenie] synonym: "inhibition of spindle biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of spindle formation" NARROW [GOC:TermGenie] synonym: "negative regulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of bipolar spindle formation" EXACT [GOC:TermGenie] synonym: "negative regulation of spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of spindle formation" EXACT [GOC:TermGenie] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:0090169 ! regulation of spindle assembly is_a: GO:1902116 ! negative regulation of organelle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0051225 ! spindle assembly relationship: negatively_regulates GO:0051225 ! spindle assembly created_by: hbye creation_date: 2017-01-17T10:26:37Z [Term] id: GO:1905832 name: positive regulation of spindle assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of spindle assembly." [GO_REF:0000058, GOC:TermGenie, PMID:27689799] synonym: "activation of bipolar spindle biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of bipolar spindle formation" NARROW [GOC:TermGenie] synonym: "activation of spindle assembly" NARROW [GOC:TermGenie] synonym: "activation of spindle biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of spindle formation" NARROW [GOC:TermGenie] synonym: "positive regulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of bipolar spindle formation" EXACT [GOC:TermGenie] synonym: "positive regulation of spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of spindle formation" EXACT [GOC:TermGenie] synonym: "up regulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of bipolar spindle formation" EXACT [GOC:TermGenie] synonym: "up regulation of spindle assembly" EXACT [GOC:TermGenie] synonym: "up regulation of spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of spindle formation" EXACT [GOC:TermGenie] synonym: "up-regulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of bipolar spindle formation" EXACT [GOC:TermGenie] synonym: "up-regulation of spindle assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of spindle formation" EXACT [GOC:TermGenie] synonym: "upregulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of bipolar spindle formation" EXACT [GOC:TermGenie] synonym: "upregulation of spindle assembly" EXACT [GOC:TermGenie] synonym: "upregulation of spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of spindle formation" EXACT [GOC:TermGenie] is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:0090169 ! regulation of spindle assembly is_a: GO:1902117 ! positive regulation of organelle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0051225 ! spindle assembly relationship: positively_regulates GO:0051225 ! spindle assembly created_by: hbye creation_date: 2017-01-17T10:26:46Z [Term] id: GO:1905902 name: regulation of mesoderm formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesoderm formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23939491] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0001707 ! mesoderm formation relationship: regulates GO:0001707 ! mesoderm formation created_by: rph creation_date: 2017-02-03T12:28:20Z [Term] id: GO:1905903 name: negative regulation of mesoderm formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23939491] synonym: "down regulation of mesoderm formation" EXACT [GOC:TermGenie] synonym: "down-regulation of mesoderm formation" EXACT [GOC:TermGenie] synonym: "downregulation of mesoderm formation" EXACT [GOC:TermGenie] synonym: "inhibition of mesoderm formation" NARROW [GOC:TermGenie] is_a: GO:1905902 ! regulation of mesoderm formation is_a: GO:2000381 ! negative regulation of mesoderm development intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0001707 ! mesoderm formation relationship: negatively_regulates GO:0001707 ! mesoderm formation created_by: rph creation_date: 2017-02-03T12:28:29Z [Term] id: GO:1905904 name: positive regulation of mesoderm formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesoderm formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23939491] synonym: "activation of mesoderm formation" NARROW [GOC:TermGenie] synonym: "up regulation of mesoderm formation" EXACT [GOC:TermGenie] synonym: "up-regulation of mesoderm formation" EXACT [GOC:TermGenie] synonym: "upregulation of mesoderm formation" EXACT [GOC:TermGenie] is_a: GO:1905902 ! regulation of mesoderm formation is_a: GO:2000382 ! positive regulation of mesoderm development intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0001707 ! mesoderm formation relationship: positively_regulates GO:0001707 ! mesoderm formation created_by: rph creation_date: 2017-02-03T12:28:38Z [Term] id: GO:1990138 name: neuron projection extension namespace: biological_process def: "Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:BHF, GOC:rl, PMID:22790009] synonym: "neurite extension" NARROW [] synonym: "neuron process extension" EXACT [] synonym: "neuron protrusion extension" EXACT [] synonym: "neuronal cell projection extension" EXACT [] is_a: GO:0048588 ! developmental cell growth is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0048812 ! neuron projection morphogenesis created_by: pr creation_date: 2013-07-08T08:40:45Z [Term] id: GO:2000026 name: regulation of multicellular organismal development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol] is_a: GO:0050793 ! regulation of developmental process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007275 ! multicellular organism development relationship: regulates GO:0007275 ! multicellular organism development created_by: tb creation_date: 2010-08-05T11:25:59Z [Term] id: GO:2000027 name: regulation of animal organ morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of animal organ morphogenesis." [GOC:obol] synonym: "regulation of histogenesis and organogenesis" RELATED [GOC:obol] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009887 ! animal organ morphogenesis relationship: regulates GO:0009887 ! animal organ morphogenesis created_by: tb creation_date: 2010-08-05T11:26:27Z [Term] id: GO:2000040 name: regulation of planar cell polarity pathway involved in axis elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in axis elongation." [GOC:dph] is_a: GO:2000095 ! regulation of Wnt signaling pathway, planar cell polarity pathway intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0003402 ! planar cell polarity pathway involved in axis elongation relationship: regulates GO:0003402 ! planar cell polarity pathway involved in axis elongation created_by: dph creation_date: 2010-08-18T02:47:49Z [Term] id: GO:2000041 name: negative regulation of planar cell polarity pathway involved in axis elongation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in axis elongation." [GOC:dph] is_a: GO:2000040 ! regulation of planar cell polarity pathway involved in axis elongation is_a: GO:2000051 ! negative regulation of non-canonical Wnt signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0003402 ! planar cell polarity pathway involved in axis elongation relationship: negatively_regulates GO:0003402 ! planar cell polarity pathway involved in axis elongation created_by: dph creation_date: 2010-08-18T02:47:54Z [Term] id: GO:2000050 name: regulation of non-canonical Wnt signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of non-canonical Wnt signaling pathway." [GOC:obol, GOC:yaf] synonym: "regulation of beta-catenin-independent Wnt receptor signaling pathway" EXACT [GOC:obol] synonym: "regulation of non-canonical Wnt receptor signaling pathway" EXACT [] synonym: "regulation of non-canonical Wnt receptor signalling pathway" EXACT [GOC:mah] synonym: "regulation of non-canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] is_a: GO:0030111 ! regulation of Wnt signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0035567 ! non-canonical Wnt signaling pathway relationship: regulates GO:0035567 ! non-canonical Wnt signaling pathway created_by: jl creation_date: 2010-08-20T01:04:12Z [Term] id: GO:2000051 name: negative regulation of non-canonical Wnt signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of non-canonical Wnt signaling pathway." [GOC:obol, GOC:yaf] synonym: "negative regulation of beta-catenin-independent Wnt receptor signaling pathway" EXACT [GOC:obol] synonym: "negative regulation of non-canonical Wnt receptor signaling pathway" EXACT [] synonym: "negative regulation of non-canonical Wnt receptor signalling pathway" EXACT [GOC:mah] synonym: "negative regulation of non-canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] is_a: GO:0030178 ! negative regulation of Wnt signaling pathway is_a: GO:2000050 ! regulation of non-canonical Wnt signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0035567 ! non-canonical Wnt signaling pathway relationship: negatively_regulates GO:0035567 ! non-canonical Wnt signaling pathway created_by: jl creation_date: 2010-08-20T01:04:20Z [Term] id: GO:2000052 name: positive regulation of non-canonical Wnt signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of non-canonical Wnt-activated signaling pathway." [GOC:obol, GOC:yaf] synonym: "positive regulation of beta-catenin-independent Wnt receptor signaling pathway" EXACT [GOC:obol] synonym: "positive regulation of non-canonical Wnt receptor signaling pathway" EXACT [] synonym: "positive regulation of non-canonical Wnt receptor signalling pathway" EXACT [GOC:mah] synonym: "positive regulation of non-canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] is_a: GO:0030177 ! positive regulation of Wnt signaling pathway is_a: GO:2000050 ! regulation of non-canonical Wnt signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0035567 ! non-canonical Wnt signaling pathway relationship: positively_regulates GO:0035567 ! non-canonical Wnt signaling pathway created_by: jl creation_date: 2010-08-20T01:04:25Z [Term] id: GO:2000053 name: regulation of Wnt signaling pathway involved in dorsal/ventral axis specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification." [GOC:obol, GOC:yaf] synonym: "regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification" EXACT [] synonym: "regulation of Wnt receptor signalling pathway involved in dorsal/ventral axis specification" EXACT [GOC:mah] synonym: "regulation of Wnt-activated signaling pathway involved in dorsal/ventral axis specification" EXACT [GOC:signaling] is_a: GO:0030111 ! regulation of Wnt signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0044332 ! Wnt signaling pathway involved in dorsal/ventral axis specification relationship: regulates GO:0044332 ! Wnt signaling pathway involved in dorsal/ventral axis specification created_by: jl creation_date: 2010-08-20T01:13:28Z [Term] id: GO:2000054 name: negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification." [GOC:obol, GOC:yaf] synonym: "negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification" EXACT [] synonym: "negative regulation of Wnt receptor signalling pathway involved in dorsal/ventral axis specification" EXACT [GOC:mah] synonym: "negative regulation of Wnt-activated signaling pathway involved in dorsal/ventral axis specification" EXACT [GOC:signaling] is_a: GO:0030178 ! negative regulation of Wnt signaling pathway is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000053 ! regulation of Wnt signaling pathway involved in dorsal/ventral axis specification intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0044332 ! Wnt signaling pathway involved in dorsal/ventral axis specification relationship: negatively_regulates GO:0044332 ! Wnt signaling pathway involved in dorsal/ventral axis specification created_by: jl creation_date: 2010-08-20T01:13:35Z [Term] id: GO:2000055 name: positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification." [GOC:obol] synonym: "positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification" EXACT [] synonym: "positive regulation of Wnt receptor signalling pathway involved in dorsal/ventral axis specification" EXACT [GOC:mah] synonym: "positive regulation of Wnt-activated signaling pathway involved in dorsal/ventral axis specification" EXACT [GOC:signaling] is_a: GO:0030177 ! positive regulation of Wnt signaling pathway is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000053 ! regulation of Wnt signaling pathway involved in dorsal/ventral axis specification intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0044332 ! Wnt signaling pathway involved in dorsal/ventral axis specification relationship: positively_regulates GO:0044332 ! Wnt signaling pathway involved in dorsal/ventral axis specification created_by: jl creation_date: 2010-08-20T01:13:40Z [Term] id: GO:2000095 name: regulation of Wnt signaling pathway, planar cell polarity pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway." [GOC:BHF] synonym: "regulation of non-canonical Wnt signaling pathway" RELATED [GOC:obol] synonym: "regulation of PCP pathway" EXACT [GOC:obol] synonym: "regulation of Wnt receptor signaling pathway, planar cell polarity pathway" EXACT [] synonym: "regulation of Wnt receptor signalling pathway, planar cell polarity pathway" EXACT [GOC:obol] synonym: "regulation of Wnt-activated signaling pathway, planar cell polarity pathway" EXACT [GOC:signaling] synonym: "regulation of Wnt-JNK signaling pathway" RELATED [GOC:obol] synonym: "regulation of Wnt-PCP signaling pathway" RELATED [GOC:obol] is_a: GO:0090175 ! regulation of establishment of planar polarity is_a: GO:2000050 ! regulation of non-canonical Wnt signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway relationship: regulates GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway created_by: jl creation_date: 2010-09-08T01:07:39Z [Term] id: GO:2000096 name: positive regulation of Wnt signaling pathway, planar cell polarity pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway." [GOC:BHF] synonym: "positive regulation of non-canonical Wnt signaling pathway" RELATED [GOC:obol] synonym: "positive regulation of PCP pathway" EXACT [GOC:obol] synonym: "positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway" EXACT [] synonym: "positive regulation of Wnt receptor signalling pathway, planar cell polarity pathway" EXACT [GOC:obol] synonym: "positive regulation of Wnt-activated signaling pathway, planar cell polarity pathway" EXACT [GOC:signaling] synonym: "positive regulation of Wnt-JNK signaling pathway" RELATED [GOC:obol] synonym: "positive regulation of Wnt-PCP signaling pathway" RELATED [GOC:obol] is_a: GO:2000052 ! positive regulation of non-canonical Wnt signaling pathway is_a: GO:2000095 ! regulation of Wnt signaling pathway, planar cell polarity pathway intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway relationship: positively_regulates GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway created_by: jl creation_date: 2010-09-08T01:07:42Z [Term] id: GO:2000099 name: regulation of establishment or maintenance of bipolar cell polarity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment or maintenance of bipolar cell polarity." [GOC:obol] is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0061245 ! establishment or maintenance of bipolar cell polarity relationship: regulates GO:0061245 ! establishment or maintenance of bipolar cell polarity created_by: dph creation_date: 2010-09-14T04:40:51Z [Term] id: GO:2000112 name: regulation of cellular macromolecule biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular macromolecule biosynthetic process." [GOC:obol] synonym: "regulation of cellular biopolymer biosynthetic process" EXACT [GOC:obol] synonym: "regulation of cellular macromolecule anabolism" EXACT [GOC:obol] synonym: "regulation of cellular macromolecule biosynthesis" EXACT [GOC:obol] synonym: "regulation of cellular macromolecule formation" EXACT [GOC:obol] synonym: "regulation of cellular macromolecule synthesis" EXACT [GOC:obol] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0031326 ! regulation of cellular biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0034645 ! cellular macromolecule biosynthetic process relationship: regulates GO:0034645 ! cellular macromolecule biosynthetic process created_by: tb creation_date: 2010-09-15T08:55:45Z [Term] id: GO:2000113 name: negative regulation of cellular macromolecule biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular macromolecule biosynthetic process." [GOC:obol] synonym: "negative regulation of cellular biopolymer biosynthetic process" EXACT [GOC:obol] synonym: "negative regulation of cellular macromolecule anabolism" EXACT [GOC:obol] synonym: "negative regulation of cellular macromolecule biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of cellular macromolecule formation" EXACT [GOC:obol] synonym: "negative regulation of cellular macromolecule synthesis" EXACT [GOC:obol] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0034645 ! cellular macromolecule biosynthetic process relationship: negatively_regulates GO:0034645 ! cellular macromolecule biosynthetic process created_by: tb creation_date: 2010-09-15T08:55:48Z [Term] id: GO:2000114 name: regulation of establishment of cell polarity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment of cell polarity." [GOC:dph] synonym: "regulation of bud site selection/establishment of cell polarity" RELATED [GOC:obol] synonym: "regulation of cell polarization" EXACT [GOC:obol] is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0030010 ! establishment of cell polarity relationship: regulates GO:0030010 ! establishment of cell polarity created_by: dph creation_date: 2010-09-16T01:22:36Z [Term] id: GO:2000116 name: regulation of cysteine-type endopeptidase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity." [GOC:obol, GOC:yaf] synonym: "regulation of lysosomal cysteine-type endopeptidase" RELATED [GOC:obol] synonym: "regulation of thiol endopeptidase activity" EXACT [GOC:obol] is_a: GO:0052548 ! regulation of endopeptidase activity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0004197 ! cysteine-type endopeptidase activity relationship: regulates GO:0004197 ! cysteine-type endopeptidase activity created_by: jl creation_date: 2010-09-23T10:24:33Z [Term] id: GO:2000117 name: negative regulation of cysteine-type endopeptidase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cysteine-type endopeptidase activity." [GOC:obol, GOC:yaf] synonym: "negative regulation of lysosomal cysteine-type endopeptidase" RELATED [GOC:obol] synonym: "negative regulation of thiol endopeptidase activity" EXACT [GOC:obol] is_a: GO:0010951 ! negative regulation of endopeptidase activity is_a: GO:2000116 ! regulation of cysteine-type endopeptidase activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0004197 ! cysteine-type endopeptidase activity relationship: negatively_regulates GO:0004197 ! cysteine-type endopeptidase activity created_by: jl creation_date: 2010-09-23T10:24:35Z [Term] id: GO:2000136 name: regulation of cell proliferation involved in heart morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0061323 ! cell proliferation involved in heart morphogenesis relationship: regulates GO:0061323 ! cell proliferation involved in heart morphogenesis created_by: dph creation_date: 2010-09-29T12:43:53Z [Term] id: GO:2000137 name: negative regulation of cell proliferation involved in heart morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0061323 ! cell proliferation involved in heart morphogenesis relationship: negatively_regulates GO:0061323 ! cell proliferation involved in heart morphogenesis created_by: dph creation_date: 2010-09-29T12:43:55Z [Term] id: GO:2000138 name: positive regulation of cell proliferation involved in heart morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0061323 ! cell proliferation involved in heart morphogenesis relationship: positively_regulates GO:0061323 ! cell proliferation involved in heart morphogenesis created_by: dph creation_date: 2010-09-29T12:43:57Z [Term] id: GO:2000145 name: regulation of cell motility namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell motility." [GOC:mah] synonym: "regulation of cell locomotion" EXACT [GOC:obol] synonym: "regulation of cell movement" RELATED [GOC:obol] synonym: "regulation of movement of a cell" EXACT [GOC:obol] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0051270 ! regulation of cellular component movement intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0048870 ! cell motility relationship: regulates GO:0048870 ! cell motility created_by: mah creation_date: 2010-10-01T09:41:21Z [Term] id: GO:2000146 name: negative regulation of cell motility namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility." [GOC:mah] synonym: "negative regulation of cell locomotion" EXACT [GOC:obol] synonym: "negative regulation of cell movement" RELATED [GOC:obol] synonym: "negative regulation of movement of a cell" EXACT [GOC:obol] is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0051271 ! negative regulation of cellular component movement is_a: GO:2000145 ! regulation of cell motility intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0048870 ! cell motility relationship: negatively_regulates GO:0048870 ! cell motility created_by: mah creation_date: 2010-10-01T09:41:26Z [Term] id: GO:2000147 name: positive regulation of cell motility namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell motility." [GOC:mah] synonym: "positive regulation of cell locomotion" EXACT [GOC:obol] synonym: "positive regulation of cell movement" RELATED [GOC:obol] synonym: "positive regulation of movement of a cell" EXACT [GOC:obol] is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0051272 ! positive regulation of cellular component movement is_a: GO:2000145 ! regulation of cell motility intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0048870 ! cell motility relationship: positively_regulates GO:0048870 ! cell motility created_by: mah creation_date: 2010-10-01T09:41:30Z [Term] id: GO:2000167 name: regulation of planar cell polarity pathway involved in neural tube closure namespace: biological_process def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in neural tube closure." [GOC:dph] is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0051960 ! regulation of nervous system development is_a: GO:0090178 ! regulation of establishment of planar polarity involved in neural tube closure is_a: GO:2000095 ! regulation of Wnt signaling pathway, planar cell polarity pathway intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0090179 ! planar cell polarity pathway involved in neural tube closure relationship: regulates GO:0090179 ! planar cell polarity pathway involved in neural tube closure created_by: dph creation_date: 2010-10-05T01:08:53Z [Term] id: GO:2000168 name: negative regulation of planar cell polarity pathway involved in neural tube closure namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in neural tube closure." [GOC:dph] is_a: GO:2000051 ! negative regulation of non-canonical Wnt signaling pathway is_a: GO:2000167 ! regulation of planar cell polarity pathway involved in neural tube closure intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0090179 ! planar cell polarity pathway involved in neural tube closure relationship: negatively_regulates GO:0090179 ! planar cell polarity pathway involved in neural tube closure created_by: dph creation_date: 2010-10-05T01:08:56Z [Term] id: GO:2000177 name: regulation of neural precursor cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0061351 ! neural precursor cell proliferation relationship: regulates GO:0061351 ! neural precursor cell proliferation created_by: dph creation_date: 2010-10-13T12:40:41Z [Term] id: GO:2000178 name: negative regulation of neural precursor cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:2000177 ! regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0061351 ! neural precursor cell proliferation relationship: negatively_regulates GO:0061351 ! neural precursor cell proliferation created_by: dph creation_date: 2010-10-13T12:40:43Z [Term] id: GO:2000179 name: positive regulation of neural precursor cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:2000177 ! regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0061351 ! neural precursor cell proliferation relationship: positively_regulates GO:0061351 ! neural precursor cell proliferation created_by: dph creation_date: 2010-10-13T12:40:45Z [Term] id: GO:2000241 name: regulation of reproductive process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reproductive process." [GOC:mah] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0022414 ! reproductive process relationship: regulates GO:0022414 ! reproductive process created_by: mah creation_date: 2010-11-10T02:44:02Z [Term] id: GO:2000242 name: negative regulation of reproductive process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process." [GOC:mah] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0022414 ! reproductive process relationship: negatively_regulates GO:0022414 ! reproductive process created_by: mah creation_date: 2010-11-10T02:44:05Z [Term] id: GO:2000243 name: positive regulation of reproductive process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of reproductive process." [GOC:mah] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0022414 ! reproductive process relationship: positively_regulates GO:0022414 ! reproductive process created_by: mah creation_date: 2010-11-10T02:44:08Z [Term] id: GO:2000252 name: negative regulation of feeding behavior namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior." [GOC:obol] synonym: "negative regulation of behavioral response to food" EXACT [GOC:obol] synonym: "negative regulation of behavioural response to food" EXACT [GOC:obol] synonym: "negative regulation of drinking" RELATED [GOC:obol] synonym: "negative regulation of eating" RELATED [GOC:obol] synonym: "negative regulation of feeding behaviour" EXACT [GOC:obol] is_a: GO:0048521 ! negative regulation of behavior is_a: GO:0060259 ! regulation of feeding behavior intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007631 ! feeding behavior relationship: negatively_regulates GO:0007631 ! feeding behavior created_by: yaf creation_date: 2010-11-18T11:24:14Z [Term] id: GO:2000253 name: positive regulation of feeding behavior namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of feeding behavior." [GOC:obol] synonym: "positive regulation of behavioral response to food" EXACT [GOC:obol] synonym: "positive regulation of behavioural response to food" EXACT [GOC:obol] synonym: "positive regulation of drinking" RELATED [GOC:obol] synonym: "positive regulation of eating" RELATED [GOC:obol] synonym: "positive regulation of feeding behaviour" EXACT [GOC:obol] is_a: GO:0048520 ! positive regulation of behavior is_a: GO:0060259 ! regulation of feeding behavior intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007631 ! feeding behavior relationship: positively_regulates GO:0007631 ! feeding behavior created_by: yaf creation_date: 2010-11-18T11:24:18Z [Term] id: GO:2000380 name: regulation of mesoderm development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesoderm development." [GOC:BHF] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007498 ! mesoderm development relationship: regulates GO:0007498 ! mesoderm development created_by: vk creation_date: 2011-02-15T03:09:46Z [Term] id: GO:2000381 name: negative regulation of mesoderm development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development." [GOC:BHF] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:2000380 ! regulation of mesoderm development intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007498 ! mesoderm development relationship: negatively_regulates GO:0007498 ! mesoderm development created_by: vk creation_date: 2011-02-15T03:10:02Z [Term] id: GO:2000382 name: positive regulation of mesoderm development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesoderm development." [GOC:BHF] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000380 ! regulation of mesoderm development intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007498 ! mesoderm development relationship: positively_regulates GO:0007498 ! mesoderm development created_by: vk creation_date: 2011-02-15T03:10:12Z [Term] id: GO:2000383 name: regulation of ectoderm development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ectoderm development." [GOC:BHF] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007398 ! ectoderm development relationship: regulates GO:0007398 ! ectoderm development created_by: vk creation_date: 2011-02-15T03:17:10Z [Term] id: GO:2000384 name: negative regulation of ectoderm development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development." [GOC:BHF] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:2000383 ! regulation of ectoderm development intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007398 ! ectoderm development relationship: negatively_regulates GO:0007398 ! ectoderm development created_by: vk creation_date: 2011-02-15T03:17:27Z [Term] id: GO:2000385 name: positive regulation of ectoderm development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ectoderm development." [GOC:BHF] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000383 ! regulation of ectoderm development intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007398 ! ectoderm development relationship: positively_regulates GO:0007398 ! ectoderm development created_by: vk creation_date: 2011-02-15T03:17:39Z [Term] id: GO:2000542 name: negative regulation of gastrulation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation." [GOC:obol] is_a: GO:0010470 ! regulation of gastrulation is_a: GO:0045992 ! negative regulation of embryonic development intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007369 ! gastrulation relationship: negatively_regulates GO:0007369 ! gastrulation created_by: yaf creation_date: 2011-04-01T04:10:08Z [Term] id: GO:2000543 name: positive regulation of gastrulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gastrulation." [GOC:obol] is_a: GO:0010470 ! regulation of gastrulation is_a: GO:0040019 ! positive regulation of embryonic development intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007369 ! gastrulation relationship: positively_regulates GO:0007369 ! gastrulation created_by: yaf creation_date: 2011-04-01T04:10