ODNAE: Ontology of Drug Neuropathy Adverse Events
type: Ontology
contributor: Junguk Hur
creator: Abra Guo
contributor: Jane Bane
date: 2016-05-16
subject: An ontology for the annotation of the adverse event domain.
description: ODNAE is an extension of OAE with a focus on drug-associated neuropathy adverse events.
version info: Vision Release; 1.0.13
contributor: Yu Lin
contributor: Guoqian Jiang
format: OWL-DL
editor note: Product version
creator: Rebecca Racz
creator: Yongqun "Oliver" He (YH)

Display_Name
type: AnnotationProperty
type: DatatypeProperty
code: C264
imported from: NDF-RT.owl

MeSH_DUI
type: AnnotationProperty
type: DatatypeProperty
code: C134
imported from: NDF-RT.owl

MeSH_Name
type: AnnotationProperty
type: DatatypeProperty
code: C287
imported from: NDF-RT.owl

NUI
type: AnnotationProperty
type: DatatypeProperty
code: C10490107818172
imported from: NDF-RT.owl

RxNorm_CUI
type: AnnotationProperty
type: DatatypeProperty
code: C818
imported from: NDF-RT.owl

Synonym
type: AnnotationProperty
type: DatatypeProperty
code: C136
imported from: NDF-RT.owl

UMLS_CUI
type: AnnotationProperty
type: DatatypeProperty
code: C140
imported from: NDF-RT.owl

code
type: AnnotationProperty
type: DatatypeProperty
read only: 1
code: AHC0
imported from: NDF-RT.owl

is_bearer_of
type: AnnotationProperty
type: ObjectProperty
sub property of: has specific dependent at some time
sub property of: topObjectProperty
label: bearer of at some time
label: is bearer of
imported from: http://purl.obolibrary.org/obo/omrse.owl
editor note: Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'bearer of at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'bearer of@en'(x,y,t)
editor note: BFO2 Reference: independent continuant that is not a spatial region
BFO CLIF specification label: bearerOfAt
has associated axiom(fol): (iff (bearerOfAt a b t) (and (specificallyDependsOnAt b a t) (IndependentContinuant a) (not (SpatialRegion a)) (existsAt b t))) // axiom label in BFO2 CLIF: [053-004]
BFO OWL specification label: bearer-of_st
editor note: BFO2 Reference: specifically dependent continuant
definition: b bearer_of c at t =Def. c s-depends_on b at t & b is an independent continuant that is not a spatial region. (axiom label in BFO2 Reference: [053-004])
alternative term: bearer of
alternative term: bearer_of
imported from: bfo.owl
imported from: dron.owl
imported from: oae.owl
imported from: obi.owl

BFO OWL specification label
type: AnnotationProperty
curator notes: Really of interest to developers only
definition: Relates an entity in the ontology to the name of the variable that is used to represent it in the code that generates the BFO OWL file from the lispy specification.
sub property of: label

BFO CLIF specification label
type: AnnotationProperty
definition source: Person:Alan Ruttenberg
curator notes: Really of interest to developers only
definition: Relates an entity in the ontology to the term that is used to represent it in the the CLIF specification of BFO2
sub property of: label

editor preferred term
type: AnnotationProperty
label: editor preferred label
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
term editor: PERSON:Daniel Schober
definition: The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English)
editor preferred term: editor preferred label
editor preferred term: editor preferred term
has curation status: ready for release

example of usage
type: AnnotationProperty
definition: A phrase describing how a class name should be used. May also include other kinds of examples that facilitate immediate understanding of a class semantics, such as widely known prototypical subclasses or instances of the class. Although essential for high level terms, examples for low level terms (e.g., Affymetrix HU133 array) are not
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
term editor: PERSON:Daniel Schober
editor preferred term: example
editor preferred term: example of usage
has curation status: ready for release

has curation status
type: AnnotationProperty
definition source: OBI_0000281
term editor: PERSON:Alan Ruttenberg
term editor: PERSON:Bill Bug
term editor: PERSON:Melanie Courtot
editor preferred term: has curation status

definition
type: AnnotationProperty
label: textual definition
editor preferred term: definition
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
term editor: PERSON:Daniel Schober
definition: The official OBI definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.
definition: The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.
has curation status: ready for release

editor note
type: AnnotationProperty
is metadata tag: 1
database_cross_reference: IAO:0000116
id: editor_note
shorthand: editor_note
has_obo_namespace: uberon
definition: An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology.
definition source: GROUP:OBI:<http://purl.obfoundry.org/obo/obi>
term editor: PERSON:Daniel Schober
editor preferred term: editor note
has curation status: ready for release

term editor
type: AnnotationProperty
label: definition editor
editor note: 20110707, MC: label update to term editor and definition modified accordingly. See http://code.google.com/p/information-artifact-ontology/issues/detail?id=115.
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
definition: Name of editor entering the definition in the file. The definition editor is a point of contact for information regarding the term. The definition editor may be, but is not always, the author of the definition, which may have been worked upon by several people
definition: Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people
term editor: PERSON:Daniel Schober
editor preferred term: definition editor
editor preferred term: term editor
has curation status: ready for release

alternative term
type: AnnotationProperty
definition: An alternative name for a class or property which means the same thing as the preferred name (semantically equivalent)
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
term editor: PERSON:Daniel Schober
editor preferred term: alternative term
has curation status: pending final vetting

definition source
type: AnnotationProperty
definition source: Discussion on obo-discuss mailing-list, see http://bit.ly/hgm99w
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
term editor: PERSON:Daniel Schober
editor preferred term: definition source
definition: formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007
has curation status: ready for release

curator notes
type: AnnotationProperty
label: curator note
is metadata tag: 1
database_cross_reference: IAO:0000232
id: curator_notes
shorthand: curator_notes
has_obo_namespace: uberon
definition: An administrative note of use for a curator but of no use for a user
term editor: PERSON:Alan Ruttenberg
editor preferred term: curator note
has curation status: ready for release

imported from
type: AnnotationProperty
definition: For external terms/classes, the ontology from which the term was imported
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
term editor: PERSON:Alan Ruttenberg
term editor: PERSON:Melanie Courtot
editor preferred term: imported from
has curation status: pending final vetting

expand expression to
type: AnnotationProperty

elucidation
type: AnnotationProperty

has associated axiom(nl)
type: AnnotationProperty

has associated axiom(fol)
type: AnnotationProperty

Chinese translation
type: AnnotationProperty
term editor: YH, JX
comment: a chinese translation represents a chinese translation of the existing term.

temporal interpretation
type: AnnotationProperty
definition: An assertion that holds between an OWL Object Property and a temporal interpretation that elucidates how OWL Class Axioms that use this property are to be interpreted in a temporal context.
sub property of: logical macro assertion on an object property

logical macro assertion on an object property
type: AnnotationProperty

external_definition
type: AnnotationProperty
is metadata tag: 1
definition: An alternate textual definition for a class taken unmodified from an external source. This definition may have been used to derive a generalized definition for the new class.
comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO
database_cross_reference: UBPROP:0000001
shorthand: external_definition
id: external_definition
has_obo_namespace: uberon

axiom_lost_from_external_ontology
type: AnnotationProperty
is metadata tag: 1
definition: A textual description of an axiom loss in this ontology compared to an external ontology.
comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO
database_cross_reference: UBPROP:0000002
shorthand: axiom_lost_from_external_ontology
id: axiom_lost_from_external_ontology
has_obo_namespace: uberon

homology_notes
type: AnnotationProperty
is metadata tag: 1
definition: Notes on the homology status of this class.
comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO
database_cross_reference: UBPROP:0000003
shorthand: homology_notes
id: homology_notes
has_obo_namespace: uberon

has_relational_adjective
type: AnnotationProperty
is metadata tag: 1
database_cross_reference: UBPROP:0000007
curator notes: Used to connect a class to an adjectival form of its label. For example, a class with label 'intestine' may have a relational adjective 'intestinal'.
id: has_relational_adjective
shorthand: has_relational_adjective
has_obo_namespace: uberon

taxon_notes
type: AnnotationProperty
is metadata tag: 1
definition: Notes on the how instances of this class vary across species.
database_cross_reference: UBPROP:0000008
shorthand: taxon_notes
id: taxon_notes
has_obo_namespace: uberon

structure_notes
type: AnnotationProperty
is metadata tag: 1
definition: Notes on the structure, composition or histology of instances of this class.
editor note: This annotation property may be replaced with an annotation property from an external ontology such as IAO
database_cross_reference: UBPROP:0000010
id: structure_notes
shorthand: structure_notes
has_obo_namespace: uberon

external_ontology_notes
type: AnnotationProperty
is metadata tag: 1
definition: Notes on how similar or equivalent classes are represented in other ontologies.
editor note: This annotation property may be replaced with an annotation property from an external ontology such as IAO
database_cross_reference: UBPROP:0000012
shorthand: external_ontology_notes
id: external_ontology_notes
has_obo_namespace: uberon

has_RxCUI
type: AnnotationProperty

cumbo
type: AnnotationProperty
comment: CUMBO
sub property of: subset_property

disjointness axiom removed
type: AnnotationProperty
comment: A class which has a weakened disjointness axiom, to avoid inconsistency. These are kept separately in the uberon_disjoint_from_strict ontology.
sub property of: subset_property

early development
type: AnnotationProperty
comment: A class that represents an early developmental structure, like a blastocyst. This part of the ontology is undergoing review to remove inappropriate grouping classes.
sub property of: subset_property

efo slim
type: AnnotationProperty
comment: EFO slim
sub property of: subset_property

functional classification
type: AnnotationProperty
comment: functional_classification
sub property of: subset_property

grouping class
type: AnnotationProperty
comment: Subset consisting of classes creating for grouping purposes
sub property of: subset_property

inconsistent with fma
type: AnnotationProperty
comment: classes that have some inconsistency with FMA
sub property of: subset_property

major organ
type: AnnotationProperty
comment: somewhat fuzzy grouping for analysis purposes, currently composed of something like: liver, heart, skeletal, kidney, bladder, brain, skin, mouth, esophagus, stomach, small intestine, large intestines, trachea nose, lungs, brain, spinal cord, peripheral nerves, kidneys, ureters, bladder, urethra, gonads
sub property of: subset_property

organ slim
type: AnnotationProperty
comment: organs, excluding individual muscles and skeletal elements
sub property of: subset_property

uberon slim
type: AnnotationProperty
comment: Uberon slim - somewhat arbitrary subset that excludes obscure terms and deep compositional terms
sub property of: subset_property

upper level
type: AnnotationProperty
comment: abstract upper-level terms not directly useful for analysis
sub property of: subset_property

vertebrate core
type: AnnotationProperty
comment: core classes typically found across vertebrates. one purpose is to create a rough set of terms that could be used to start a new vertebrate AO
sub property of: subset_property

upper level
type: AnnotationProperty
comment: abstract upper-level terms not directly useful for analysis
sub property of: subset_property

subset_property
type: AnnotationProperty

has_alternative_id
type: AnnotationProperty

has_broad_synonym
type: AnnotationProperty

database_cross_reference
type: AnnotationProperty

has_exact_synonym
type: AnnotationProperty

has_narrow_synonym
type: AnnotationProperty

has_obo_namespace
type: AnnotationProperty

has_related_synonym
type: AnnotationProperty

in_subset
type: AnnotationProperty

shorthand
type: AnnotationProperty

label
type: AnnotationProperty

depicted_by
type: AnnotationProperty
is metadata tag: 1
shorthand: foaf-depicted_by
id: foaf-depicted_by
has_obo_namespace: uberon

part_of
type: ObjectProperty
type: TransitiveProperty
label: part of
database_cross_reference: BFO:0000050
shorthand: part_of
id: part_of
has_obo_namespace: uberon
sub property of: overlaps
imported from: go.owl
imported from: oae.owl
imported from: uberon.owl

has_part
type: ObjectProperty
type: TransitiveProperty
label: has part
database_cross_reference: BFO:0000051
id: has_part
shorthand: has_part
has_obo_namespace: uberon
inverse of: part_of
sub property of: overlaps
sub property of: has material contribution from
imported from: oae.owl
imported from: uberon.owl

realized in
type: ObjectProperty
BFO CLIF specification label: realizedIn
BFO OWL specification label: realized-in
elucidation: [copied from inverse property 'realizes'] to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003])
has associated axiom(fol): (forall (x y z t) (if (and (RealizableEntity x) (Process y) (realizesAt y x t) (bearerOfAt z x t)) (hasParticipantAt y z t))) // axiom label in BFO2 CLIF: [106-002]
has associated axiom(nl): if a realizable entity b is realized in a process p, then p stands in the has_participant relation to the bearer of b. (axiom label in BFO2 Reference: [106-002])
imported from: bfo.owl
imported from: oae.owl
imported from: obi.owl

has participant
type: ObjectProperty
editor preferred term: has participant
alternative term: has_participant
imported from: oae.owl
imported from: obi.owl

preceded_by
type: ObjectProperty
type: TransitiveProperty
label: is preceded by
label: preceded by
database_cross_reference: BFO:0000062
definition: X preceded_by Y iff: end(Y) before_or_simultaneous_with start(X)
has_exact_synonym: is preceded by
shorthand: preceded_by
id: preceded_by
has_exact_synonym: takes place after
has_obo_namespace: uberon
comment: X preceded_by Y iff: end(Y) before_or_simultaneous_with start(X)
alternative term: preceded by
alternative term: preceded_by
alternative term: proceeds
alternative term: starts_after
inverse of: precedes
sub property of: ends_after
imported from: oae.owl
imported from: ro.owl
imported from: uberon.owl
property chain axiom: happens_during
property chain axiom: starts_during

precedes
type: ObjectProperty
type: TransitiveProperty
database_cross_reference: BFO:0000063
id: precedes
shorthand: precedes
has_obo_namespace: uberon
sub property of: temporally related to
imported from: oae.owl
imported from: uberon.owl

occurs in
type: ObjectProperty
database_cross_reference: BFO:0000066
shorthand: occurs_in
BFO OWL specification label: occurs-in
BFO CLIF specification label: occursIn
definition: b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t [XXX-001
inverse of: contains process
imported from: bfo.owl
imported from: go.owl
imported from: oae.owl
imported from: uberon.owl

contains process
type: ObjectProperty
database_cross_reference: BFO:0000067
id: contains_process
shorthand: contains_process
has_obo_namespace: uberon
imported from: oae.owl
imported from: uberon.owl
inverse of: occurs in

has quality at some time
type: ObjectProperty
BFO OWL specification label: has-q_st
sub property of: is_bearer_of
imported from: bfo.owl
imported from: oae.owl
imported from: obi.owl

has specific dependent at some time
type: ObjectProperty
example of usage: [copied from inverse property 'specifically depends on at some time'] a shape s-depends_on the shaped object
BFO OWL specification label: has-s-dep_st
elucidation: [copied from inverse property 'specifically depends on at some time'] To say that b s-depends_on a at t is to say that b and c do not share common parts & b is of its nature such that it cannot exist unless c exists & b is not a boundary of c and b is not a site of which c is the host [64
example of usage: [copied from inverse property 'specifically depends on at some time'] one-sided s-dependence of a process on something: an instance of seeing (a relational process) s-depends_on some organism and on some seen entity, which may be an occurrent or a continuant
example of usage: [copied from inverse property 'specifically depends on at some time'] the one-sided dependence of an occurrent on an independent continuant: football match on the players, the ground, the ball
example of usage: [copied from inverse property 'specifically depends on at some time'] a gait s-depends_on the walking object. (All at some specific time.)
example of usage: [copied from inverse property 'specifically depends on at some time'] A pain s-depends_on the organism that is experiencing the pain
editor note: [copied from inverse property 'specifically depends on at some time'] BFO 2 Reference: the relation of s-depends_on does not in every case require simultaneous existence of its relata. Note the difference between such cases and the cases of continuant universals defined historically: the act of answering depends existentially on the prior act of questioning; the human being who was baptized or who answered a question does not himself depend existentially on the prior act of baptism or answering. He would still exist even if these acts had never taken place.
example of usage: [copied from inverse property 'specifically depends on at some time'] one-sided s-dependence of one occurrent on multiple independent continuants: a relational process of paying cash to a merchant in exchange for a bag of figs
editor note: [copied from inverse property 'specifically depends on at some time'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'specifically depends on at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'specifically depends on@en'(x,y,t)
example of usage: [copied from inverse property 'specifically depends on at some time'] one-sided s-dependence of one occurrent on multiple independent continuants: a relational process of hitting a ball with a cricket bat
example of usage: [copied from inverse property 'specifically depends on at some time'] the one-sided dependence of an occurrent on an independent continuant: handwave on a hand
example of usage: [copied from inverse property 'specifically depends on at some time'] reciprocal s-dependence between occurrents: in a game of chess the process of playing with the white pieces is mutually dependent on the process of playing with the black pieces
example of usage: [copied from inverse property 'specifically depends on at some time'] the two-sided reciprocal s-dependence of the roles of husband and wife [20
editor note: [copied from inverse property 'specifically depends on at some time'] BFO2 Reference: specifically dependent continuant\; process; process boundary
example of usage: [copied from inverse property 'specifically depends on at some time'] the three-sided reciprocal s-dependence of the hue, saturation and brightness of a color [45
example of usage: [copied from inverse property 'specifically depends on at some time'] reciprocal s-dependence between occurrents: a process of buying and the associated process of selling
example of usage: [copied from inverse property 'specifically depends on at some time'] the three-sided reciprocal s-dependence of the pitch, timbre and volume of a tone [45
example of usage: [copied from inverse property 'specifically depends on at some time'] reciprocal s-dependence between occurrents: a process of increasing the volume of a portion of gas while temperature remains constant and the associated process of decreasing the pressure exerted by the gas
example of usage: [copied from inverse property 'specifically depends on at some time'] one-sided s-dependence of a dependent continuant on an independent continuant: an instance of temperature s-depends_on some organism
example of usage: [copied from inverse property 'specifically depends on at some time'] one-sided s-dependence of one occurrent on another: a process of obeying a command is dependent on a prior process of issuing a command
example of usage: [copied from inverse property 'specifically depends on at some time'] one-sided s-dependence of a process on something: a process of cell death s-depends_on a cell
editor note: [copied from inverse property 'specifically depends on at some time'] BFO 2 Reference: S-dependence is just one type of dependence among many; it is what, in the literature, is referred to as ‘existential dependence’ [87, 46, 65, 20
editor note: [copied from inverse property 'specifically depends on at some time'] BFO 2 Reference: An entity – for example an act of communication or a game of football – can s-depends_on more than one entity. Complex phenomena for example in the psychological and social realms (such as inferring, commanding and requesting) or in the realm of multi-organismal biological processes (such as infection and resistance), will involve multiple families of dependence relations, involving both continuants and occurrents [1, 4, 28
example of usage: [copied from inverse property 'specifically depends on at some time'] one-sided s-dependence of a dependent continuant on an independent continuant: an instance of headache s-depends_on some head
example of usage: [copied from inverse property 'specifically depends on at some time'] one-sided s-dependence of one occurrent on another: a process of answering a question is dependent on a prior process of asking a question
imported from: bfo.owl
imported from: oae.owl

adverse event occurs in
type: ObjectProperty
definition: a 'occurs in' relation that is applied at the adverse event setting and indicates where an adverse event occurs in.
term editor: Yongqun He
sub property of: occurs in
imported from: oae.owl

has_specified_input
type: ObjectProperty
editor note: 8/17/09: specified inputs of one process are not necessarily specified inputs of a larger process that it is part of. This is in contrast to how 'has participant' works.
term editor: PERSON: Bjoern Peters
term editor: PERSON: Larry Hunter
term editor: PERSON: Melanie Coutot
definition: A relation between a planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of.
term editor: PERSON: Alan Ruttenberg
editor preferred term: has_specified_input
example of usage: see is_input_of example_of_usage
sub property of: has participant
has curation status: ready for release
imported from: obi.owl

has_specified_output
type: ObjectProperty
term editor: PERSON: Bjoern Peters
term editor: PERSON: Larry Hunter
term editor: PERSON: Melanie Courtot
definition: A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of.
term editor: PERSON: Alan Ruttenberg
editor preferred term: has_specified_output
sub property of: has participant
has curation status: ready for release
imported from: obi.owl

inheres in
type: ObjectProperty
database_cross_reference: RO:0000052
shorthand: inheres_in
sub property of: inheres in part of
imported from: oae.owl
imported from: uberon.owl

bearer of
type: ObjectProperty
database_cross_reference: RO:0000053
shorthand: bearer_of
id: bearer_of
has_obo_namespace: uberon
editor note: A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist.
definition: a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence
editor preferred term: bearer of
alternative term: bearer_of
alternative term: is bearer of
example of usage: this apple is bearer of this red color
example of usage: this vase is bearer of this fragility
range: specifically dependent continuant
inverse of: inheres in
temporal interpretation: axiom holds for all times
imported from: oae.owl
imported from: ro.owl
imported from: uberon.owl

role of
type: ObjectProperty

has quality
type: ObjectProperty
database_cross_reference: RO:0000086
id: has_quality
shorthand: has_quality
has_obo_namespace: uberon
sub property of: bearer of
imported from: oae.owl
imported from: uberon.owl

has role
type: ObjectProperty
editor note: A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists.
definition: a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence
alternative term: has_role
example of usage: this person has role this investigator role (more colloquially: this person has this role of investigator)
domain: independent continuant
range: role
sub property of: bearer of
inverse of: role of
imported from: ro.owl

location_of
type: ObjectProperty
type: TransitiveProperty
label: location of
database_cross_reference: RO:0001015
id: location_of
shorthand: location_of
has_obo_namespace: uberon
imported from: oae.owl
imported from: uberon.owl

located_in
type: ObjectProperty
type: TransitiveProperty
label: located in
database_cross_reference: RO:0001025
id: located_in
shorthand: located_in
has_obo_namespace: uberon
inverse of: location_of
imported from: oae.owl
imported from: uberon.owl

boundary of
type: ObjectProperty
database_cross_reference: RO:0002000
definition: The relationships between a boundary (a 2D immaterial entity) and the material entity that it delimits.
shorthand: boundary_of
sub property of: mereotopologically related to
imported from: oae.owl
imported from: uberon.owl

has boundary
type: ObjectProperty
database_cross_reference: RO:0002002
definition: The relationship between a material entity and the boundary (2D immaterial entity) that delimits it.
id: has_boundary
shorthand: has_boundary
has_obo_namespace: uberon
inverse of: boundary of
sub property of: mereotopologically related to
imported from: oae.owl
imported from: uberon.owl

innervated_by
type: ObjectProperty
has_alternative_id: FMA:85999
database_cross_reference: RO:0002005
has_alternative_id: dbprop:nerve
comment: http://code.google.com/p/obo-relations/issues/detail
shorthand: innervated_by
id: innervated_by
has_exact_synonym: nerve supply
has_obo_namespace: uberon
inverse of: innervates
imported from: oae.owl
imported from: uberon.owl
property chain axiom: branching_part_of

before_or_simultaneous_with
type: ObjectProperty
database_cross_reference: RO:0002081
shorthand: before_or_simultaneous_with
sub property of: temporally related to
imported from: oae.owl
imported from: uberon.owl

simultaneous_with
type: ObjectProperty
type: TransitiveProperty
database_cross_reference: RO:0002082
definition: Relation between occurrents, shares start and end boundaries.
has_exact_synonym: coincides_with
has_exact_synonym: is_equal_to
shorthand: simultaneous_with
id: simultaneous_with
has_obo_namespace: uberon
sub property of: before_or_simultaneous_with
sub property of: starts
sub property of: ends
imported from: oae.owl
imported from: uberon.owl

ends_after
type: ObjectProperty
type: TransitiveProperty
database_cross_reference: RO:0002086
shorthand: ends_after
sub property of: temporally related to
imported from: oae.owl
imported from: uberon.owl

immediately_preceded_by
type: ObjectProperty
external_definition: A non-transitive temporal relation in which one process immediately precedes another process, such that there is no interval of time between the two processes[SIO:000251].
database_cross_reference: RO:0002087
definition: X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)
has_exact_synonym: directly preceded by
shorthand: immediately_preceded_by
id: immediately_preceded_by
has_exact_synonym: is directly preceded by
has_exact_synonym: is immediately preceded by
has_exact_synonym: starts_at_end_of
has_obo_namespace: uberon
sub property of: preceded_by
inverse of: immediately_precedes
imported from: oae.owl
imported from: uberon.owl

immediately_precedes
type: ObjectProperty
database_cross_reference: RO:0002090
shorthand: immediately_precedes
sub property of: precedes
imported from: oae.owl
imported from: uberon.owl

starts_during
type: ObjectProperty
imported from: oae.owl

happens_during
type: ObjectProperty
type: TransitiveProperty
imported from: oae.owl

overlaps
type: ObjectProperty
definition: A overlaps B if they share some part in common.
expand expression to: BFO_0000051 some (BFO_0000050 some ?Y)
database_cross_reference: RO:0002131
shorthand: overlaps
id: overlaps
has_obo_namespace: uberon
definition: x overlaps y iff they have some part in common.
definition: x overlaps y if and only if there exists some z such that x has part z and z part of y
sub property of: mereotopologically related to
imported from: oae.owl
imported from: uberon.owl

innervates
type: ObjectProperty
database_cross_reference: RO:0002134
comment: http://code.google.com/p/obo-relations/issues/detail
shorthand: innervates
id: innervates
has_obo_namespace: uberon
imported from: oae.owl
imported from: uberon.owl
sub property of: topObjectProperty
property chain axiom: part_of

continuous_with
type: ObjectProperty
type: SymmetricProperty
label: continuous with
database_cross_reference: RO:0002150
definition: X continuous_with Y if and only if X and Y share a fiat boundary.
shorthand: continuous_with
id: continuous_with
has_obo_namespace: uberon
sub property of: mereotopologically related to
imported from: oae.owl
imported from: uberon.owl

only in taxon
type: ObjectProperty
label: only_in_taxon
database_cross_reference: RO:0002160
definition: S only_in_taxon T iff: S SubClassOf in_taxon only T
id: only_in_taxon
shorthand: only_in_taxon
has_obo_namespace: uberon
definition: x only in taxon y if and only if x is in taxon y, and there is no other organism z such that y!=z a and x is in taxon z.
sub property of: in taxon
imported from: oae.owl
imported from: uberon.owl

in taxon
type: ObjectProperty
database_cross_reference: RO:0002162
shorthand: in_taxon
id: in_taxon
has_obo_namespace: uberon
definition: x is in taxon y if an only if y is an organism, and the relationship between x and y is one of: part of (reflexive), developmentally preceded by, derives from, secreted by, expressed.
sub property of: evolutionarily related to
imported from: oae.owl
imported from: uberon.owl
property chain axiom: existence ends during
property chain axiom: has potential to develop into
property chain axiom: part_of
property chain axiom: overlaps
property chain axiom: innervated_by
property chain axiom: existence starts during
property chain axiom: attaches_to
property chain axiom: developmentally_induced_by
property chain axiom: supplies
property chain axiom: develops_from
property chain axiom: produces
property chain axiom: connected to
property chain axiom: has developmental contribution from
property chain axiom: located_in
property chain axiom: connects
property chain axiom: produced_by
property chain axiom: continuous_with

connected to
type: ObjectProperty
definition: Binary relationship: x connected_to y if and only if there exists some z such that z connects x and y in a ternary connected_to(x,y,z) relationship.
comment: Connection does not imply overlaps.
database_cross_reference: RO:0002170
id: connected_to
shorthand: connected_to
has_obo_namespace: uberon
sub property of: mereotopologically related to
imported from: oae.owl
imported from: uberon.owl
sub property of: transitively_connected to

connects
type: ObjectProperty
definition: Binary relationship: z connects x if and only if there exists some y such that z connects x and y in a ternary connected_to(x,y,z) relationship.
database_cross_reference: RO:0002176
id: connects
shorthand: connects
editor note: this is currently used for both structural relationships (such as between a valve and the chamber it connects) and abstract relationships (anatomical lines and the entities they connect)
has_obo_namespace: uberon
sub property of: mereotopologically related to
imported from: oae.owl
imported from: uberon.owl

attaches_to_part_of
type: ObjectProperty
label: attached to part of
database_cross_reference: RO:0002177
shorthand: attached_to_part_of
shorthand: attaches_to_part_of
id: attaches_to_part_of
has_obo_namespace: uberon
definition: a is attached to part of b if a is attached to b, or a is attached to some p, where p is part of b.
sub property of: mereotopologically related to
imported from: oae.owl
imported from: uberon.owl
property chain axiom: attaches_to
property chain axiom: part_of

supplies
type: ObjectProperty
has_alternative_id: FMA:86003
database_cross_reference: RO:0002178
has_exact_synonym: arterial supply of
definition: relation between an artery and the structure is supplies with blood.
comment: source: FMA
id: supplies
shorthand: supplies
has_obo_namespace: uberon
definition: Relation between an arterial structure and another structure, where the arterial structure acts as a conduit channeling fluid, substance or energy.
sub property of: connected to
imported from: oae.owl
imported from: uberon.owl

develops_from
type: ObjectProperty
type: TransitiveProperty
label: develops from
database_cross_reference: RO:0002202
id: develops_from
shorthand: develops_from
has_obo_namespace: uberon
definition: x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y
sub property of: has developmental contribution from
sub property of: developmentally preceded by
sub property of: has material contribution from
imported from: oae.owl
imported from: uberon.owl
property chain axiom: part_of

directly_develops_from
type: ObjectProperty
label: directly develops from
database_cross_reference: RO:0002207
shorthand: directly_develops_from
id: directly_develops_from
has_obo_namespace: uberon
definition: Candidate definition: x directly_develops from y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p, and a substantial portion of the matter of y comes from x, and the start of x is coincident with or after the end of y
sub property of: develops_from
imported from: oae.owl
imported from: uberon.owl

capable_of
type: ObjectProperty
label: capable of
database_cross_reference: RO:0002215
id: capable_of
shorthand: capable_of
has_obo_namespace: uberon
definition: A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process.
sub property of: functionally related to
imported from: oae.owl
imported from: uberon.owl

capable_of_part_of
type: ObjectProperty
label: capable of part of
database_cross_reference: RO:0002216
id: capable_of_part_of
shorthand: capable_of_part_of
has_obo_namespace: uberon
definition: c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p.
sub property of: functionally related to
imported from: oae.owl
imported from: uberon.owl

temporally related to
type: ObjectProperty
database_cross_reference: RO:0002222
shorthand: temporally_related_to
imported from: oae.owl
imported from: uberon.owl

starts
type: ObjectProperty
database_cross_reference: RO:0002223
definition: Relation between occurrents, shares a start boundary with.
id: starts
shorthand: starts
has_obo_namespace: uberon
definition: inverse of starts with
sub property of: part_of
sub property of: temporally related to
imported from: oae.owl
imported from: uberon.owl

ends
type: ObjectProperty
database_cross_reference: RO:0002229
definition: Relation between occurrents, shares an end boundary with.
shorthand: ends
id: ends
has_exact_synonym: finishes
has_obo_namespace: uberon
definition: inverse of ends with
sub property of: part_of
sub property of: temporally related to
inverse of: ends with
imported from: oae.owl
imported from: uberon.owl

ends with
type: ObjectProperty
type: TransitiveProperty
database_cross_reference: RO:0002230
shorthand: ends_with
definition: x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
sub property of: has_part
sub property of: temporally related to
imported from: oae.owl
imported from: uberon.owl

has developmental contribution from
type: ObjectProperty
type: TransitiveProperty
database_cross_reference: RO:0002254
id: has_developmental_contribution_from
shorthand: has_developmental_contribution_from
has_obo_namespace: uberon
definition: x has developmental contribution from y iff x has some part z such that z develops from y
sub property of: developmentally preceded by
sub property of: has material contribution from
imported from: oae.owl
imported from: uberon.owl
property chain axiom: has_part
property chain axiom: develops_from

developmentally_induced_by
type: ObjectProperty
label: developmentally induced by
database_cross_reference: RO:0002256
shorthand: developmentally_induced_by
id: developmentally_induced_by
comment: sources for developmentally_induced_by relationships in Uberon: Developmental Biology, Gilbert, 8th edition, figure 6.5(F)
definition: t1 developmentally_induced_by t2 if there is a process of organ induction (GO:0001759) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor tissue type T to T', where T' develops_from T.
has_obo_namespace: uberon
definition: t1 induced_by t2 if there is a process of developmental induction (GO:0031128) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor anatomical structure type T to T', where T' develops_from T
sub property of: developmentally preceded by
imported from: oae.owl
imported from: uberon.owl

developmentally preceded by
type: ObjectProperty
database_cross_reference: RO:0002258
shorthand: developmentally_preceded_by
id: developmentally_preceded_by
has_obo_namespace: uberon
definition: Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p
sub property of: developmentally related to
imported from: oae.owl
imported from: uberon.owl

inheres in part of
type: ObjectProperty
database_cross_reference: RO:0002314
shorthand: inheres_in_part_of
definition: q inheres in part of w if and only if there exists some p such that q inheres in p and p part of w.
sub property of: depends on
imported from: oae.owl
imported from: uberon.owl

evolutionarily related to
type: ObjectProperty
database_cross_reference: RO:0002320
shorthand: evolutionarily_related_to
definition: A relationship that holds via some environmental process
imported from: oae.owl
imported from: uberon.owl

mereotopologically related to
type: ObjectProperty
database_cross_reference: RO:0002323
shorthand: mereotopologically_related_to
definition: A mereological relationship or a topological relationship
imported from: oae.owl
imported from: uberon.owl

developmentally related to
type: ObjectProperty
database_cross_reference: RO:0002324
shorthand: developmentally_related_to
definition: A relationship that holds via some developmental process (GO:0032502)
imported from: oae.owl
imported from: uberon.owl

functionally related to
type: ObjectProperty
database_cross_reference: RO:0002328
id: functionally_related_to
shorthand: functionally_related_to
has_obo_namespace: uberon
imported from: oae.owl
imported from: uberon.owl

attaches_to
type: ObjectProperty
type: SymmetricProperty
label: attached to
has_alternative_id: FMA:85990
database_cross_reference: RO:0002371
shorthand: attached_to
shorthand: attaches_to
id: attaches_to
has_obo_namespace: uberon
sub property of: connects
sub property of: attaches_to_part_of
imported from: oae.owl
imported from: uberon.owl

in branching relationship with
type: ObjectProperty
database_cross_reference: RO:0002375
shorthand: in_branching_relationship_with
sub property of: part_of
sub property of: mereotopologically related to
imported from: oae.owl
imported from: uberon.owl

branching_part_of
type: ObjectProperty
label: branching part of
has_alternative_id: FMA:85994
database_cross_reference: RO:0002380
id: branching_part_of
shorthand: branching_part_of
has_obo_namespace: uberon
editor note: we need to check if FMA branch_of implies part_of. the relation we intend to use here should - for example, see vestibulocochlear nerve
definition: x is a branching part of y if and only if x is part of y and x is a branch_of the main stem of y
sub property of: part_of
sub property of: in branching relationship with
imported from: oae.owl
imported from: uberon.owl

has developmental potential involving
type: ObjectProperty
database_cross_reference: RO:0002384
shorthand: has_developmental_potential_involving
definition: x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction).
sub property of: developmentally related to
imported from: oae.owl
imported from: uberon.owl

has potential to develop into
type: ObjectProperty
database_cross_reference: RO:0002387
shorthand: has_potential_to_develop_into
id: has_potential_to_develop_into
has_obo_namespace: uberon
definition: x has the potential to develop into y iff x develops into y or if x is capable of developing into y
sub property of: has developmental potential involving
imported from: oae.owl
imported from: uberon.owl

composed_primarily_of
type: ObjectProperty
label: composed primarily of
database_cross_reference: RO:0002473
has_alternative_id: UBREL:0000002
shorthand: composed_primarily_of
id: composed_primarily_of
has_obo_namespace: uberon
definition: x composed_primarily_of y iff: more than half of the mass of x is made from parts of y
definition: x composed_primarily_of y if and only if more than half of the mass of x is made from y or units of the same type as y.
sub property of: has_part
imported from: oae.owl
imported from: uberon.owl

relation between structure and stage
type: ObjectProperty
database_cross_reference: RO:0002487
shorthand: relation_between_structure_and_stage
imported from: oae.owl
imported from: uberon.owl

existence starts during
type: ObjectProperty
has_alternative_id: BFO:0000068
database_cross_reference: RO:0002488
definition: Relation between continuant c and occurrent s, such that every instance of c comes into existing during some s.
has_exact_synonym: begins_to_exist_during
shorthand: existence_starts_during
id: existence_starts_during
has_obo_namespace: uberon
definition: c existence starts during s iff start_of(c) part_of s
sub property of: existence overlaps
sub property of: existence starts during or after
imported from: oae.owl
imported from: uberon.owl
property chain axiom: part_of

existence starts with
type: ObjectProperty
database_cross_reference: RO:0002489
definition: Relation between continuant and occurrent, such that c comes into existence at the start of p.
shorthand: existence_starts_with
id: existence_starts_with
has_obo_namespace: uberon
definition: c existence starts during s iff start_of(c) = start_of(s)
sub property of: existence starts during
imported from: oae.owl
imported from: uberon.owl

existence overlaps
type: ObjectProperty
database_cross_reference: RO:0002490
shorthand: existence_overlaps
sub property of: relation between structure and stage
imported from: oae.owl
imported from: uberon.owl

existence ends during
type: ObjectProperty
has_alternative_id: BFO:0000069
database_cross_reference: RO:0002492
definition: Relation between continuant c and occurrent s, such that every instance of c ceases to exist during some s, if it does not die prematurely.
has_exact_synonym: ceases_to_exist_during
shorthand: existence_ends_during
id: existence_ends_during
has_obo_namespace: uberon
sub property of: existence overlaps
sub property of: existence ends during or before
imported from: oae.owl
imported from: uberon.owl
property chain axiom: part_of

existence ends with
type: ObjectProperty
database_cross_reference: RO:0002493
definition: Relation between continuant and occurrent, such that c ceases to exist at the end of p.
shorthand: existence_ends_with
id: existence_ends_with
has_obo_namespace: uberon
sub property of: existence ends during
imported from: oae.owl
imported from: uberon.owl

transformation of
type: ObjectProperty
type: TransitiveProperty
database_cross_reference: RO:0002494
shorthand: transformation_of
id: transformation_of
has_exact_synonym: transforms from
has_obo_namespace: uberon
definition: x transformation of y if x is the immediate transformation of y, or is linked to y through a chain of transformation relationships
sub property of: develops_from
imported from: oae.owl
imported from: uberon.owl

immediate transformation of
type: ObjectProperty
database_cross_reference: RO:0002495
has_exact_synonym: direct_transformation_of
shorthand: immediate_transformation_of
id: immediate_transformation_of
has_exact_synonym: immediately transforms from
has_obo_namespace: uberon
definition: x immediate transformation of y iff x immediately succeeds y temporally at a time boundary t, and all of the matter present in x at t is present in y at t, and all the matter in y at t is present in x at t
sub property of: directly_develops_from
sub property of: transformation of
imported from: oae.owl
imported from: uberon.owl

existence starts during or after
type: ObjectProperty
database_cross_reference: RO:0002496
shorthand: existence_starts_during_or_after
id: existence_starts_during_or_after
has_obo_namespace: uberon
sub property of: relation between structure and stage
imported from: oae.owl
imported from: uberon.owl
property chain axiom: preceded_by
property chain axiom: simultaneous_with
property chain axiom: part_of
property chain axiom: developmentally preceded by

existence ends during or before
type: ObjectProperty
database_cross_reference: RO:0002497
id: existence_ends_during_or_before
shorthand: existence_ends_during_or_before
has_obo_namespace: uberon
sub property of: relation between structure and stage
imported from: oae.owl
imported from: uberon.owl
property chain axiom: developmentally succeeded by
property chain axiom: part_of
property chain axiom: simultaneous_with
property chain axiom: precedes

depends on
type: ObjectProperty
database_cross_reference: RO:0002502
shorthand: depends_on
imported from: oae.owl
imported from: uberon.owl

has material contribution from
type: ObjectProperty
type: TransitiveProperty
database_cross_reference: RO:0002507
shorthand: has_material_contribution_from
id: has_material_contribution_from
has_obo_namespace: uberon
imported from: oae.owl
imported from: uberon.owl
property chain axiom: has_part
property chain axiom: develops_from

produces
type: ObjectProperty
database_cross_reference: RO:0003000
definition: a produces b if some process that occurs_in a has_output b, where a and b are material entities. Examples: hybridoma cell line produces monoclonal antibody reagent; chondroblast produces avascular GAG-rich matrix.
id: produces
shorthand: produces
has_obo_namespace: uberon
inverse of: produced_by
imported from: oae.owl
imported from: uberon.owl

produced_by
type: ObjectProperty
label: produced by
database_cross_reference: RO:0003001
id: produced_by
shorthand: produced_by
has_obo_namespace: uberon
imported from: oae.owl
imported from: uberon.owl

existence starts and ends during
type: ObjectProperty
id: existence_starts_and_ends_during
has_obo_namespace: uberon
sub property of: existence starts during
sub property of: existence ends during
imported from: oae.owl
imported from: uberon.owl

transitively_connected to
type: ObjectProperty
type: TransitiveProperty
id: transitively_connected_to
has_obo_namespace: uberon
imported from: oae.owl
imported from: uberon.owl

has_proper_part
type: ObjectProperty
type: TransitiveProperty
imported from: http://purl.org/obo/owl/relationship
has_obo_namespace: relationship
has_alternative_id: OBO_REL:0000007
imported from: dron.owl
sub property of: topObjectProperty

Physiochemical Activity [MoA]
type: Class
subclass of: role in cellular and molecular interactions
Display_Name: Physiochemical Activity
NUI: N0000000065
RxNorm_CUI: 989958
code: C308
UMLS_CUI: C1372991
imported from: NDF-RT.owl

Small Ion Transport Pump Interactions [MoA]
type: Class
subclass of: Active Transporter Interactions [MoA]
RxNorm_CUI: 986087
NUI: N0000000066
code: C310
Display_Name: Small Ion Transport Pump Interactions
UMLS_CUI: C1373107
imported from: NDF-RT.owl

HER Receptor Family Interactions [MoA]
type: Class
subclass of: Receptor Protein Kinase Interactions [MoA]
Synonym: EGFR Family Interactions
code: C312
Synonym: Human Epidermal Growth Factor Receptor Family Interactions
NUI: N0000000067
Display_Name: HER Receptor Family Interactions
RxNorm_CUI: 986672
Synonym: Epidermal Growth Factor Receptor Family Interactions
UMLS_CUI: C2916814
Synonym: HER Family Interactions
imported from: NDF-RT.owl

Calcium Channel Antagonists [MoA]
type: Class
subclass of: Calcium Channel Interactions [MoA]
RxNorm_CUI: 986242
MeSH_DUI: D002121
MeSH_Name: Calcium Channel Blockers
UMLS_CUI: C2757014
NUI: N0000000069
Display_Name: Calcium Channel Antagonists
code: C316
Synonym: Calcium Channel Blocker
imported from: NDF-RT.owl

Angiotensin 2 Receptor Antagonists [MoA]
type: Class
subclass of: G-Protein-linked Receptor Interactions [MoA]
RxNorm_CUI: 984935
code: C318
NUI: N0000000070
Synonym: Angiotensin II Receptor Blockers
UMLS_CUI: C2757003
Synonym: Angiotensin II Receptor Antagonists
Display_Name: Angiotensin 2 Receptor Antagonists
imported from: NDF-RT.owl

Active Transporter Interactions [MoA]
type: Class
subclass of: Receptor Interactions [MoA]
Display_Name: Active Transporter Interactions
RxNorm_CUI: 1031287
code: C322
NUI: N0000000072
UMLS_CUI: C1373104
imported from: NDF-RT.owl

Protease Inhibitors [MoA]
type: Class
subclass of: Enzyme Inhibitors [MoA]
Display_Name: Protease Inhibitors
NUI: N0000000076
RxNorm_CUI: 992709
MeSH_Name: Protease Inhibitors
code: C330
UMLS_CUI: C2756997
MeSH_DUI: D011480
imported from: NDF-RT.owl

Immunologic Factors [MoA]
type: Class
subclass of: Immunologic and Biological Factors [MoA]
code: C342
Display_Name: Immunologic Factors
MeSH_Name: Immunologic Factors
UMLS_CUI: C2757006
RxNorm_CUI: 993127
MeSH_DUI: D007155
NUI: N0000000082
imported from: NDF-RT.owl

Leukotriene Receptor Antagonists [MoA]
type: Class
subclass of: Leukotriene Receptor Interactions [MoA]
UMLS_CUI: C2757015
RxNorm_CUI: 992724
code: C344
NUI: N0000000083
Display_Name: Leukotriene Receptor Antagonists
imported from: NDF-RT.owl

Sex Hormone Receptor Antagonists [MoA]
type: Class
subclass of: Steroid Receptor Antagonists [MoA]
UMLS_CUI: C1373000
NUI: N0000000084
Display_Name: Sex Hormone Receptor Antagonists
RxNorm_CUI: 985639
code: C346
imported from: NDF-RT.owl

Receptor Interactions [MoA]
type: Class
subclass of: role in cellular and molecular interactions
UMLS_CUI: C1372999
code: C348
Display_Name: Receptor Interactions
RxNorm_CUI: 988560
NUI: N0000000085
imported from: NDF-RT.owl

Chelating Activity [MoA]
type: Class
subclass of: Binding Activity [MoA]
NUI: N0000000087
MeSH_Name: Chelating Activity
Display_Name: Chelating Activity
code: C352
RxNorm_CUI: 1025213
MeSH_DUI: D002614
UMLS_CUI: C1527256
imported from: NDF-RT.owl

Adrenergic Antagonists [MoA]
type: Class
subclass of: Adrenergic Receptor Interactions [MoA]
UMLS_CUI: C2757018
RxNorm_CUI: 993129
Display_Name: Adrenergic Antagonists
MeSH_Name: Adrenergic Antagonists
NUI: N0000000092
MeSH_DUI: D018674
code: C362
imported from: NDF-RT.owl

Cholinergic Muscarinic Receptor Interactions [MoA]
type: Class
subclass of: G-Protein-linked Receptor Interactions [MoA]
subclass of: Cholinergic Interactions [MoA]
code: C372
RxNorm_CUI: 986244
NUI: N0000000097
UMLS_CUI: C1373009
Display_Name: Cholinergic Muscarinic Receptor Interactions
imported from: NDF-RT.owl

Thymidylate Synthetase Inhibitors [MoA]
type: Class
subclass of: Nucleic Acid Synthesis Inhibitors [MoA]
NUI: N0000000098
RxNorm_CUI: 993154
code: C374
Display_Name: Thymidylate Synthetase Inhibitors
UMLS_CUI: C2756988
imported from: NDF-RT.owl

Adrenergic alpha-Antagonists [MoA]
type: Class
subclass of: Adrenergic Antagonists [MoA]
RxNorm_CUI: 1023426
NUI: N0000000099
Synonym: alpha-Adrenergic Antagonists
Display_Name: Adrenergic alpha-Antagonists
UMLS_CUI: C2756989
MeSH_Name: Adrenergic alpha-Antagonists
Synonym: Alpha-adrenergic Blocker
MeSH_DUI: D000317
code: C376
imported from: NDF-RT.owl

Norepinephrine Uptake Inhibitors [MoA]
type: Class
subclass of: Norepinephrine Transporter Interactions [MoA]
subclass of: Restriction
  on property: realized in
  some values from: inhibition of norepinephrine uptake
RxNorm_CUI: 989028
Display_Name: Norepinephrine Uptake Inhibitors
UMLS_CUI: C2757023
code: C382
MeSH_DUI: D018759
MeSH_Name: Adrenergic Uptake Inhibitors
NUI: N0000000102
imported from: NDF-RT.owl

Reverse Transcriptase Inhibitors [MoA]
type: Class
subclass of: Nucleic Acid Synthesis Inhibitors [MoA]
NUI: N0000000103
UMLS_CUI: C2757067
RxNorm_CUI: 993157
MeSH_Name: Reverse Transcriptase Inhibitors
code: C384
MeSH_DUI: D018894
Display_Name: Reverse Transcriptase Inhibitors
imported from: NDF-RT.owl

Cholinergic Muscarinic Agonists [MoA]
type: Class
subclass of: Cholinergic Muscarinic Receptor Interactions [MoA]
subclass of: Cholinergic Agonists [MoA]
code: C386
Display_Name: Cholinergic Muscarinic Agonists
RxNorm_CUI: 990721
NUI: N0000000104
UMLS_CUI: C2757026
imported from: NDF-RT.owl

Neurotransmitter Transporter Interactions [MoA]
type: Class
subclass of: Active Transporter Interactions [MoA]
Display_Name: Neurotransmitter Transporter Interactions
UMLS_CUI: C1373006
NUI: N0000000105
code: C388
RxNorm_CUI: 985066
imported from: NDF-RT.owl

Serotonin Uptake Inhibitors [MoA]
type: Class
subclass of: Serotonin Transporter Interactions [MoA]
subclass of: Restriction
  on property: realized in
  some values from: negative regulation of serotonin uptake
UMLS_CUI: C2757053
Display_Name: Serotonin Uptake Inhibitors
MeSH_Name: Serotonin Uptake Inhibitors
code: C396
MeSH_DUI: D017367
NUI: N0000000109
RxNorm_CUI: 992711
imported from: NDF-RT.owl

Folic Acid Metabolism Inhibitors [MoA]
type: Class
subclass of: Nucleic Acid Synthesis Inhibitors [MoA]
UMLS_CUI: C2916820
MeSH_Name: Folic Acid Antagonists
RxNorm_CUI: 1029786
code: C400
Synonym: Folic Acid Metabolic Inhibitors
NUI: N0000000111
Display_Name: Folic Acid Metabolism Inhibitors
Synonym: Folic Acid Antagonists
MeSH_DUI: D005493
imported from: NDF-RT.owl

Dopamine Uptake Inhibitors [MoA]
type: Class
subclass of: Dopamine Transporter Interactions [MoA]
subclass of: Restriction
  on property: realized in
  some values from: negative regulation of dopamine uptake involved in synaptic transmission
code: C406
NUI: N0000000114
UMLS_CUI: C2757017
Display_Name: Dopamine Uptake Inhibitors
RxNorm_CUI: 1028789
MeSH_DUI: D018765
MeSH_Name: Dopamine Uptake Inhibitors
imported from: NDF-RT.owl

Dopamine Agonists [MoA]
type: Class
subclass of: Dopamine Receptor Interactions [MoA]
MeSH_DUI: D018491
NUI: N0000000117
UMLS_CUI: C2757007
RxNorm_CUI: 992714
code: C412
Synonym: Dopaminergic Agonist
Display_Name: Dopamine Agonists
MeSH_Name: Dopamine Agonists
imported from: NDF-RT.owl

GABA A Modulators [MoA]
type: Class
subclass of: GABA A Receptor Interactions [MoA]
UMLS_CUI: C1373017
code: C414
NUI: N0000000118
Synonym: GABA A Receptor Modulators
Display_Name: GABA A Modulators
RxNorm_CUI: 990722
imported from: NDF-RT.owl

Hydroxymethylglutaryl-CoA Reductase Inhibitors [MoA]
type: Class
subclass of: Cholesterol Synthesis Inhibitors [MoA]
subclass of: Restriction
  on property: realized in
  some values from: negative regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity
MeSH_DUI: D019161
RxNorm_CUI: 993150
UMLS_CUI: C2756999
Display_Name: Hydroxymethylglutaryl-CoA Reductase Inhibitors
code: C420
Synonym: HMG-CoA Reductase Inhibitor
Synonym: HMG-CoA Reductase Inhibitors
NUI: N0000000121
MeSH_Name: Hydroxymethylglutaryl-CoA Reductase Inhibitors
imported from: NDF-RT.owl

Adrenergic Agonists [MoA]
type: Class
subclass of: Adrenergic Receptor Interactions [MoA]
RxNorm_CUI: 1029285
code: C422
Display_Name: Adrenergic Agonists
UMLS_CUI: C2757025
NUI: N0000000122
MeSH_Name: Adrenergic Agonists
MeSH_DUI: D000322
imported from: NDF-RT.owl

Leukotriene Receptor Interactions [MoA]
type: Class
subclass of: G-Protein-linked Receptor Interactions [MoA]
UMLS_CUI: C1373014
NUI: N0000000124
Display_Name: Leukotriene Receptor Interactions
code: C426
RxNorm_CUI: 987670
imported from: NDF-RT.owl

Phosphodiesterase Inhibitors [MoA]
type: Class
subclass of: Enzyme Inhibitors [MoA]
NUI: N0000000128
MeSH_DUI: D010726
UMLS_CUI: C1656262
MeSH_Name: Phosphodiesterase Inhibitors
RxNorm_CUI: 993167
code: C434
Display_Name: Phosphodiesterase Inhibitors
imported from: NDF-RT.owl

Serotonin Antagonists [MoA]
type: Class
subclass of: Serotonin Receptor Interactions [MoA]
MeSH_DUI: D012702
NUI: N0000000130
UMLS_CUI: C2757052
code: C438
RxNorm_CUI: 993156
MeSH_Name: Serotonin Antagonists
Display_Name: Serotonin Antagonists
imported from: NDF-RT.owl

Organic Anion Transporter Interactions [MoA]
type: Class
subclass of: Active Transporter Interactions [MoA]
UMLS_CUI: C1373100
RxNorm_CUI: 987411
NUI: N0000000132
Display_Name: Organic Anion Transporter Interactions
code: C442
imported from: NDF-RT.owl

Enzyme Inhibitors [MoA]
type: Class
subclass of: role in cellular and molecular interactions
code: C444
MeSH_DUI: D004791
NUI: N0000000133
Display_Name: Enzyme Inhibitors
UMLS_CUI: C2756995
MeSH_Name: Enzyme Inhibitors
RxNorm_CUI: 1032544
imported from: NDF-RT.owl

Lipoxygenase Inhibitors [MoA]
type: Class
subclass of: Enzyme Inhibitors [MoA]
MeSH_DUI: D016859
code: C446
RxNorm_CUI: 1031400
UMLS_CUI: C2757064
MeSH_Name: Lipoxygenase Inhibitors
Display_Name: Lipoxygenase Inhibitors
NUI: N0000000134
imported from: NDF-RT.owl

Immunologic Adjuvants [MoA]
type: Class
subclass of: Biological Response Modifiers [MoA]
Synonym: Adjuvants, Immunologic
Display_Name: Immunologic Adjuvants
RxNorm_CUI: 989878
NUI: N0000000135
MeSH_Name: Adjuvants, Immunologic
MeSH_DUI: D000276
code: C448
UMLS_CUI: C1383096
imported from: NDF-RT.owl

GABA A Receptor Interactions [MoA]
type: Class
subclass of: Chloride Channel Interactions [MoA]
code: C454
NUI: N0000000138
Display_Name: GABA A Receptor Interactions
UMLS_CUI: C1373022
RxNorm_CUI: 988922
imported from: NDF-RT.owl

Calcium Channel Interactions [MoA]
type: Class
subclass of: Ion Channel Interactions [MoA]
code: C458
UMLS_CUI: C1373020
RxNorm_CUI: 990245
NUI: N0000000140
Display_Name: Calcium Channel Interactions
imported from: NDF-RT.owl

Iron Chelating Activity [MoA]
type: Class
subclass of: Metal Chelating Activity [MoA]
code: C466
RxNorm_CUI: 985781
NUI: N0000000144
MeSH_Name: Iron Chelating Activity
Display_Name: Iron Chelating Activity
MeSH_DUI: D007502
UMLS_CUI: C2757050
imported from: NDF-RT.owl

Estrogen Receptor Antagonists [MoA]
type: Class
subclass of: Sex Hormone Receptor Antagonists [MoA]
RxNorm_CUI: 984514
NUI: N0000000145
UMLS_CUI: C1373098
code: C468
Display_Name: Estrogen Receptor Antagonists
Synonym: Estrogen Receptor Inhibitor
imported from: NDF-RT.owl

Proton Pump Inhibitors [MoA]
type: Class
subclass of: Small Ion Transport Pump Interactions [MoA]
RxNorm_CUI: 986356
Display_Name: Proton Pump Inhibitors
UMLS_CUI: C1384478
NUI: N0000000147
code: C472
imported from: NDF-RT.owl

Hormone Receptor Agonists [MoA]
type: Class
subclass of: Hormone Receptor Interactions [MoA]
RxNorm_CUI: 985200
Display_Name: Hormone Receptor Agonists
code: C476
UMLS_CUI: C1373095
NUI: N0000000149
imported from: NDF-RT.owl

Protein Synthesis Inhibitors [MoA]
type: Class
subclass of: Enzyme Inhibitors [MoA]
UMLS_CUI: C2757051
RxNorm_CUI: 993158
MeSH_Name: Protein Synthesis Inhibitors
code: C478
NUI: N0000000150
Display_Name: Protein Synthesis Inhibitors
MeSH_DUI: D011500
imported from: NDF-RT.owl

G-Protein-linked Receptor Interactions [MoA]
type: Class
subclass of: Receptor Interactions [MoA]
RxNorm_CUI: 984725
code: C482
Display_Name: G-Protein-linked Receptor Interactions
UMLS_CUI: C2916797
Synonym: G-Protein-linked Receptor-Effector Interactions
NUI: N0000000152
imported from: NDF-RT.owl

Adrenergic Receptor Interactions [MoA]
type: Class
subclass of: G-Protein-linked Receptor Interactions [MoA]
RxNorm_CUI: 987972
Display_Name: Adrenergic Receptor Interactions
UMLS_CUI: C1373072
code: C484
NUI: N0000000153
imported from: NDF-RT.owl

Uncouplers [MoA]
type: Class
subclass of: Enzyme Inhibitors [MoA]
Display_Name: Uncouplers
code: C488
UMLS_CUI: C1373071
NUI: N0000000155
RxNorm_CUI: 986674
imported from: NDF-RT.owl

Chloride Channel Interactions [MoA]
type: Class
subclass of: Ion Channel Interactions [MoA]
UMLS_CUI: C1373070
NUI: N0000000156
code: C490
RxNorm_CUI: 987326
Display_Name: Chloride Channel Interactions
imported from: NDF-RT.owl

Glucocorticoid Receptor Agonists [MoA]
type: Class
subclass of: Corticosteroid Hormone Receptor Agonists [MoA]
Display_Name: Glucocorticoid Receptor Agonists
code: C496
NUI: N0000000159
RxNorm_CUI: 989879
UMLS_CUI: C1373068
imported from: NDF-RT.owl

Cyclooxygenase Inhibitors [MoA]
type: Class
subclass of: Enzyme Inhibitors [MoA]
UMLS_CUI: C2756982
MeSH_DUI: D016861
RxNorm_CUI: 992710
Display_Name: Cyclooxygenase Inhibitors
NUI: N0000000160
MeSH_Name: Cyclooxygenase Inhibitors
code: C498
imported from: NDF-RT.owl

Adrenergic beta-Antagonists [MoA]
type: Class
subclass of: Adrenergic Antagonists [MoA]
MeSH_DUI: D000319
RxNorm_CUI: 993131
MeSH_Name: Adrenergic beta-Antagonists
Synonym: Beta-adrenergic Receptor Inhibitor
code: C500
Synonym: beta-Adrenergic Antagonists
NUI: N0000000161
UMLS_CUI: C2757061
Synonym: beta-Adrenergic Receptor Inhibitor
Synonym: beta-Adrenergic Blocker
Synonym: Beta-adrenergic Blocker
Display_Name: Adrenergic beta-Antagonists
imported from: NDF-RT.owl

Steroid Receptor Antagonists [MoA]
type: Class
subclass of: Hormone Receptor Antagonists [MoA]
NUI: N0000000162
RxNorm_CUI: 987973
UMLS_CUI: C1373067
code: C502
Display_Name: Steroid Receptor Antagonists
imported from: NDF-RT.owl

Serotonin Transporter Interactions [MoA]
type: Class
subclass of: Neurotransmitter Transporter Interactions [MoA]
NUI: N0000000167
RxNorm_CUI: 987204
code: C512
Display_Name: Serotonin Transporter Interactions
UMLS_CUI: C1373063
imported from: NDF-RT.owl

Selective Estrogen Receptor Modulators [MoA]
type: Class
subclass of: Steroid Receptor Modulators [MoA]
MeSH_DUI: D020845
RxNorm_CUI: 993164
Display_Name: Selective Estrogen Receptor Modulators
NUI: N0000000168
UMLS_CUI: C2757056
code: C514
MeSH_Name: Selective Estrogen Receptor Modulators
imported from: NDF-RT.owl

Steroid Receptor Modulators [MoA]
type: Class
subclass of: Hormone Receptor Modulators [MoA]
UMLS_CUI: C1373061
code: C522
Display_Name: Steroid Receptor Modulators
NUI: N0000000172
RxNorm_CUI: 987671
imported from: NDF-RT.owl

Opioid Agonists [MoA]
type: Class
subclass of: Opioid Receptor Interactions [MoA]
subclass of: Restriction
  on property: realized in
  some values from: positive regulation of opioid receptor signaling pathway
RxNorm_CUI: 985466
UMLS_CUI: C1373059
NUI: N0000000174
Display_Name: Opioid Agonists
code: C526
imported from: NDF-RT.owl

Cytokine Receptor Superfamily Interactions [MoA]
type: Class
subclass of: Receptor Interactions [MoA]
Display_Name: Cytokine Receptor Superfamily Interactions
UMLS_CUI: C1373058
RxNorm_CUI: 984937
code: C528
NUI: N0000000175
imported from: NDF-RT.owl

Topoisomerase Inhibitors [MoA]
type: Class
subclass of: Nucleic Acid Synthesis Inhibitors [MoA]
subclass of: Restriction
  on property: realized in
  some values from: negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity
Synonym: DNA Gyrase Inhibitors
RxNorm_CUI: 989757
Display_Name: Topoisomerase Inhibitors
NUI: N0000000176
UMLS_CUI: C1384454
Synonym: Topoisomerase Inhibitor
code: C530
imported from: NDF-RT.owl

Cholinesterase Inhibitors [MoA]
type: Class
subclass of: Enzyme Inhibitors [MoA]
RxNorm_CUI: 992680
Display_Name: Cholinesterase Inhibitors
MeSH_DUI: D002800
code: C532
MeSH_Name: Cholinesterase Inhibitors
NUI: N0000000177
UMLS_CUI: C2757012
imported from: NDF-RT.owl

Sodium Channel Interactions [MoA]
type: Class
subclass of: Ion Channel Interactions [MoA]
Display_Name: Sodium Channel Interactions
code: C538
RxNorm_CUI: 987802
UMLS_CUI: C1373055
NUI: N0000000180
imported from: NDF-RT.owl

Angiotensin-converting Enzyme Inhibitors [MoA]
type: Class
subclass of: Protease Inhibitors [MoA]
code: C540
NUI: N0000000181
Synonym: Angiotensin Converting Enzyme Inhibitor
RxNorm_CUI: 992731
MeSH_DUI: D000806
UMLS_CUI: C2757044
MeSH_Name: Angiotensin-Converting Enzyme Inhibitors
Display_Name: Angiotensin-converting Enzyme Inhibitors
imported from: NDF-RT.owl

Steroid Hormone Receptor Agonists [MoA]
type: Class
subclass of: Hormone Receptor Agonists [MoA]
NUI: N0000000182
UMLS_CUI: C1373054
code: C542
Display_Name: Steroid Hormone Receptor Agonists
RxNorm_CUI: 990907
imported from: NDF-RT.owl

Acetyl Aldehyde Dehydrogenase Inhibitors [MoA]
type: Class
subclass of: Enzyme Inhibitors [MoA]
UMLS_CUI: C1373053
RxNorm_CUI: 986817
Display_Name: Acetyl Aldehyde Dehydrogenase Inhibitors
code: C544
NUI: N0000000183
imported from: NDF-RT.owl

Monoamine Oxidase Inhibitors [MoA]
type: Class
subclass of: Enzyme Inhibitors [MoA]
NUI: N0000000184
RxNorm_CUI: 992698
MeSH_DUI: D008996
MeSH_Name: Monoamine Oxidase Inhibitors
UMLS_CUI: C2756978
code: C546
Display_Name: Monoamine Oxidase Inhibitors
Synonym: MAOI
imported from: NDF-RT.owl

Progestational Hormone Receptor Agonists [MoA]
type: Class
subclass of: Sex Hormone Receptor Agonists [MoA]
Display_Name: Progestational Hormone Receptor Agonists
UMLS_CUI: C1373052
NUI: N0000000185
code: C548
RxNorm_CUI: 986818
imported from: NDF-RT.owl

Histamine H1 Receptor Antagonists [MoA]
type: Class
subclass of: Histamine Receptor Antagonists [MoA]
UMLS_CUI: C2757048
code: C558
RxNorm_CUI: 992695
Synonym: H1 Receptor Blockers
MeSH_Name: Histamine H1 Antagonists
Synonym: Histamine H1 Blockers
NUI: N0000000190
Display_Name: Histamine H1 Receptor Antagonists
Synonym: Histamine H1 Antagonists
Synonym: H1 Receptor Antagonists
MeSH_DUI: D006634
imported from: NDF-RT.owl

Dihydrofolate Reductase Inhibitors [MoA]
type: Class
subclass of: Folic Acid Metabolism Inhibitors [MoA]
subclass of: Nucleoside Synthesis Inhibitors [MoA]
UMLS_CUI: C1373048
NUI: N0000000191
code: C560
RxNorm_CUI: 441741
Display_Name: Dihydrofolate Reductase Inhibitors
imported from: NDF-RT.owl

Ion Channel Interactions [MoA]
type: Class
subclass of: Receptor Interactions [MoA]
NUI: N0000000193
UMLS_CUI: C1373047
RxNorm_CUI: 988382
Display_Name: Ion Channel Interactions
code: C564
imported from: NDF-RT.owl

Serotonin Receptor Interactions [MoA]
type: Class
subclass of: G-Protein-linked Receptor Interactions [MoA]
Display_Name: Serotonin Receptor Interactions
NUI: N0000000198
RxNorm_CUI: 988082
code: C574
UMLS_CUI: C1373043
imported from: NDF-RT.owl

Opioid Receptor Interactions [MoA]
type: Class
subclass of: G-Protein-linked Receptor Interactions [MoA]
NUI: N0000000200
RxNorm_CUI: 989758
code: C578
Display_Name: Opioid Receptor Interactions
UMLS_CUI: C1373041
imported from: NDF-RT.owl

Dopamine Receptor Interactions [MoA]
type: Class
subclass of: G-Protein-linked Receptor Interactions [MoA]
NUI: N0000000203
code: C584
UMLS_CUI: C1373039
RxNorm_CUI: 985948
Display_Name: Dopamine Receptor Interactions
imported from: NDF-RT.owl

Radiopharmaceutical Activity [MoA]
type: Class
subclass of: Physiochemical Activity [MoA]
Display_Name: Radiopharmaceutical Activity
UMLS_CUI: C2757000
RxNorm_CUI: 987975
MeSH_Name: Radiopharmaceuticals
NUI: N0000000205
MeSH_DUI: D019275
code: C588
imported from: NDF-RT.owl

Xanthine Oxidase Inhibitors [MoA]
type: Class
subclass of: Enzyme Inhibitors [MoA]
RxNorm_CUI: 984728
NUI: N0000000206
Display_Name: Xanthine Oxidase Inhibitors
UMLS_CUI: C1384464
code: C590
imported from: NDF-RT.owl

Histamine Receptor Antagonists [MoA]
type: Class
subclass of: Histamine Receptor Interactions [MoA]
MeSH_DUI: D006633
Display_Name: Histamine Receptor Antagonists
Synonym: Histamine Antagonists
code: C592
RxNorm_CUI: 989667
NUI: N0000000207
UMLS_CUI: C1383092
MeSH_Name: Histamine Antagonists
imported from: NDF-RT.owl

Adrenergic alpha-Agonists [MoA]
type: Class
subclass of: Adrenergic Agonists [MoA]
MeSH_Name: Adrenergic alpha-Agonists
Display_Name: Adrenergic alpha-Agonists
Synonym: alpha-Adrenergic Agonists
UMLS_CUI: C2757042
RxNorm_CUI: 1029039
NUI: N0000000209
MeSH_DUI: D000316
code: C596
imported from: NDF-RT.owl

Potassium Channel Interactions [MoA]
type: Class
subclass of: Ion Channel Interactions [MoA]
code: C600
NUI: N0000000211
UMLS_CUI: C1373036
RxNorm_CUI: 989960
Display_Name: Potassium Channel Interactions
imported from: NDF-RT.owl

Ribonucleotide Reductase Inhibitors [MoA]
type: Class
subclass of: Nucleic Acid Synthesis Inhibitors [MoA]
Display_Name: Ribonucleotide Reductase Inhibitors
NUI: N0000000212
code: C602
RxNorm_CUI: 441728
UMLS_CUI: C1373035
imported from: NDF-RT.owl

Receptor Protein Kinase Interactions [MoA]
type: Class
subclass of: Receptor Interactions [MoA]
code: C604
Display_Name: Receptor Protein Kinase Interactions
UMLS_CUI: C1373034
RxNorm_CUI: 986538
NUI: N0000000213
imported from: NDF-RT.owl

Sex Hormone Receptor Agonists [MoA]
type: Class
subclass of: Steroid Hormone Receptor Agonists [MoA]
RxNorm_CUI: 990080
NUI: N0000000214
code: C606
Display_Name: Sex Hormone Receptor Agonists
UMLS_CUI: C1373033
imported from: NDF-RT.owl

Histamine Receptor Interactions [MoA]
type: Class
subclass of: G-Protein-linked Receptor Interactions [MoA]
Display_Name: Histamine Receptor Interactions
RxNorm_CUI: 989394
NUI: N0000000216
code: C610
UMLS_CUI: C1373031
imported from: NDF-RT.owl

Dopamine Transporter Interactions [MoA]
type: Class
subclass of: Neurotransmitter Transporter Interactions [MoA]
NUI: N0000000219
RxNorm_CUI: 984515
UMLS_CUI: C1373028
Display_Name: Dopamine Transporter Interactions
code: C616
imported from: NDF-RT.owl

Hormone Receptor Antagonists [MoA]
type: Class
subclass of: Hormone Receptor Interactions [MoA]
RxNorm_CUI: 990790
code: C620
Display_Name: Hormone Receptor Antagonists
NUI: N0000000221
UMLS_CUI: C1373026
imported from: NDF-RT.owl

Insulin Receptor Agonists [MoA]
type: Class
subclass of: Insulin Receptor Interactions [MoA]
subclass of: Restriction
  on property: realized in
  some values from: positive regulation of cellular response to insulin stimulus
NUI: N0000000225
code: C628
UMLS_CUI: C1373092
Display_Name: Insulin Receptor Agonists
RxNorm_CUI: 986676
imported from: NDF-RT.owl

Dopamine Antagonists [MoA]
type: Class
subclass of: Dopamine Receptor Interactions [MoA]
subclass of: Restriction
  on property: realized in
  some values from: negative regulation of dopamine secretion
MeSH_Name: Dopamine Antagonists
Display_Name: Dopamine Antagonists
MeSH_DUI: D018492
UMLS_CUI: C2757008
code: C638
NUI: N0000000230
RxNorm_CUI: 1032050
imported from: NDF-RT.owl

Nucleic Acid Synthesis Inhibitors [MoA]
type: Class
subclass of: Enzyme Inhibitors [MoA]
code: C644
NUI: N0000000233
RxNorm_CUI: 993166
Display_Name: Nucleic Acid Synthesis Inhibitors
UMLS_CUI: C2757009
MeSH_Name: Nucleic Acid Synthesis Inhibitors
MeSH_DUI: D019384
imported from: NDF-RT.owl

Norepinephrine Transporter Interactions [MoA]
type: Class
subclass of: Neurotransmitter Transporter Interactions [MoA]
NUI: N0000000234
RxNorm_CUI: 988817
UMLS_CUI: C2267223
code: C646
Display_Name: Norepinephrine Transporter Interactions
imported from: NDF-RT.owl

Alkylating Activity [MoA]
type: Class
subclass of: Physiochemical Activity [MoA]
MeSH_DUI: D000477
NUI: N0000000236
code: C650
MeSH_Name: Alkylating Activity
RxNorm_CUI: 1031878
UMLS_CUI: C2756975
Display_Name: Alkylating Activity
imported from: NDF-RT.owl

Insulin Receptor Interactions [MoA]
type: Class
subclass of: Receptor Protein Kinase Interactions [MoA]
UMLS_CUI: C1373083
RxNorm_CUI: 987414
NUI: N0000000240
code: C658
Display_Name: Insulin Receptor Interactions
imported from: NDF-RT.owl

Transcription Factor Activity [MoA]
type: Class
subclass of: Receptor Interactions [MoA]
Display_Name: Transcription Factor Activity
NUI: N0000000242
UMLS_CUI: C1148759
RxNorm_CUI: 1028825
code: C662
imported from: NDF-RT.owl

Androgen Receptor Antagonists [MoA]
type: Class
subclass of: Sex Hormone Receptor Antagonists [MoA]
subclass of: Restriction
  on property: realized in
  some values from: negative regulation of androgen receptor activity
Display_Name: Androgen Receptor Antagonists
code: C664
RxNorm_CUI: 989356
UMLS_CUI: C1373082
Synonym: Androgen Receptor Inhibitor
NUI: N0000000243
imported from: NDF-RT.owl

HIV Protease Inhibitors [MoA]
type: Class
subclass of: Protease Inhibitors [MoA]
MeSH_DUI: D017320
MeSH_Name: HIV Protease Inhibitors
Synonym: Human Immunodeficiency Virus Protease Inhibitors
NUI: N0000000246
code: C670
Display_Name: HIV Protease Inhibitors
UMLS_CUI: C2756991
RxNorm_CUI: 993149
imported from: NDF-RT.owl

Biological Response Modifiers [MoA]
type: Class
subclass of: Immunologic Factors [MoA]
MeSH_Name: Biological Response Modifiers
code: C672
MeSH_DUI: D015545
NUI: N0000000247
RxNorm_CUI: 993132
Display_Name: Biological Response Modifiers
UMLS_CUI: C2757019
imported from: NDF-RT.owl

Immunologic and Biological Factors [MoA]
type: Class
subclass of: role in cellular and molecular interactions
Display_Name: Immunologic and Biological Factors
RxNorm_CUI: 1032698
MeSH_DUI: D007151
code: C686
UMLS_CUI: C0021048
MeSH_Name: Immunologic and Biological Factors
NUI: N0000000254
imported from: NDF-RT.owl

Hormone Receptor Modulators [MoA]
type: Class
subclass of: Hormone Receptor Interactions [MoA]
RxNorm_CUI: 989214
code: C688
NUI: N0000000255
UMLS_CUI: C1373075
Display_Name: Hormone Receptor Modulators
imported from: NDF-RT.owl

Serotonin Agonists [MoA]
type: Class
subclass of: Serotonin Receptor Interactions [MoA]
RxNorm_CUI: 1022850
code: C690
UMLS_CUI: C2756998
NUI: N0000000256
Display_Name: Serotonin Agonists
MeSH_Name: Serotonin Agonists
MeSH_DUI: D017366
imported from: NDF-RT.owl

Hormone Receptor Interactions [MoA]
type: Class
subclass of: Transcription Factor Activity [MoA]
NUI: N0000000257
code: C692
RxNorm_CUI: 986361
UMLS_CUI: C1373074
Display_Name: Hormone Receptor Interactions
imported from: NDF-RT.owl

Cyclooxygenase 2 Inhibitors [MoA]
type: Class
subclass of: Cyclooxygenase Inhibitors [MoA]
UMLS_CUI: C2757001
Synonym: Cyclooxygenase II Inhibitors
Synonym: COX-2 Inhibitors
code: C26942
Display_Name: Cyclooxygenase 2 Inhibitors
NUI: N0000008288
RxNorm_CUI: 993136
imported from: NDF-RT.owl

Adrenergic alpha2-Agonists [MoA]
type: Class
subclass of: Adrenergic alpha-Agonists [MoA]
UMLS_CUI: C1373110
code: C30202
Synonym: Adrenergic alpha-2 Agonists
Display_Name: Adrenergic alpha2-Agonists
Synonym: alpha-2 Adrenergic Agonists
NUI: N0000009918
RxNorm_CUI: 1035126
imported from: NDF-RT.owl

Adrenergic beta1-Antagonists [MoA]
type: Class
subclass of: Adrenergic beta-Antagonists [MoA]
Synonym: beta-1 Adrenergic Antagonists
Display_Name: Adrenergic beta1-Antagonists
code: C30212
Synonym: Adrenergic beta-1 Antagonists
RxNorm_CUI: 986189
NUI: N0000009923
UMLS_CUI: C1373134
imported from: NDF-RT.owl

Adrenergic beta2-Antagonists [MoA]
type: Class
subclass of: Adrenergic beta-Antagonists [MoA]
Display_Name: Adrenergic beta2-Antagonists
NUI: N0000009924
Synonym: beta-2 Adrenergic Antagonists
UMLS_CUI: C1373133
Synonym: Adrenergic beta-2 Antagonists
code: C30214
RxNorm_CUI: 987660
imported from: NDF-RT.owl

Para-Aminobenzoic Acid Inhibitors [MoA]
type: Class
subclass of: Enzyme Inhibitors [MoA]
UMLS_CUI: C2916799
code: C30260
Synonym: PABA Inhibitor
NUI: N0000009946
RxNorm_CUI: 984916
Display_Name: Para-Aminobenzoic Acid Inhibitors
imported from: NDF-RT.owl

Non-Nucleoside Reverse Transcriptase Inhibitors [MoA]
type: Class
subclass of: Reverse Transcriptase Inhibitors [MoA]
RxNorm_CUI: 989597
code: C30264
NUI: N0000009948
Display_Name: Non-Nucleoside Reverse Transcriptase Inhibitors
UMLS_CUI: C1373120
imported from: NDF-RT.owl

Antibody-Receptor Interactions [MoA]
type: Class
subclass of: Receptor Interactions [MoA]
subclass of: Antibody Interactions [MoA]
UMLS_CUI: C2267208
RxNorm_CUI: 985716
code: C30266
NUI: N0000009949
Display_Name: Antibody-Receptor Interactions
imported from: NDF-RT.owl

Tumor Necrosis Factor Receptor Interactions [MoA]
type: Class
subclass of: Cytokine Receptor Superfamily Interactions [MoA]
NUI: N0000009950
UMLS_CUI: C1373118
Synonym: TNF Receptor Interactions
code: C30268
RxNorm_CUI: 984657
Display_Name: Tumor Necrosis Factor Receptor Interactions
imported from: NDF-RT.owl

Sterol Synthesis Inhibitors [MoA]
type: Class
subclass of: Enzyme Inhibitors [MoA]
Display_Name: Sterol Synthesis Inhibitors
UMLS_CUI: C1373112
RxNorm_CUI: 988794
code: C30280
NUI: N0000009956
imported from: NDF-RT.owl

Bone Surface Interactions [MoA]
type: Class
subclass of: Immunologic and Biological Factors [MoA]
RxNorm_CUI: 985507
NUI: N0000009958
UMLS_CUI: C1373129
Display_Name: Bone Surface Interactions
code: C30284
imported from: NDF-RT.owl

Transpeptidase Inhibitors [MoA]
type: Class
subclass of: Enzyme Inhibitors [MoA]
Synonym: Transpepsidase Inhibitors
Synonym: PBP inhibitors
NUI: N0000010215
Display_Name: Transpeptidase Inhibitors
Synonym: penicillin binding protein Inhibitors
UMLS_CUI: C1373138
code: C31788
RxNorm_CUI: 984931
imported from: NDF-RT.owl

Antibody Interactions [MoA]
type: Class
subclass of: Immunologic Factors [MoA]
UMLS_CUI: C2916825
NUI: N0000010226
Display_Name: Antibody Interactions
code: C31810
RxNorm_CUI: 987958
imported from: NDF-RT.owl

Cellular Structure Molecule Interactions [MoA]
type: Class
subclass of: Immunologic and Biological Factors [MoA]
RxNorm_CUI: 989808
UMLS_CUI: C1373148
code: C31868
NUI: N0000010255
Display_Name: Cellular Structure Molecule Interactions
imported from: NDF-RT.owl

Tubulin Interactions [MoA]
type: Class
subclass of: Cellular Structure Molecule Interactions [MoA]
Display_Name: Tubulin Interactions
NUI: N0000010256
code: C31870
UMLS_CUI: C1373147
RxNorm_CUI: 1023254
imported from: NDF-RT.owl

beta Tubulin Interactions [MoA]
type: Class
subclass of: Tubulin Interactions [MoA]
RxNorm_CUI: 986466
code: C31878
Display_Name: beta Tubulin Interactions
UMLS_CUI: C1373143
NUI: N0000010260
imported from: NDF-RT.owl

Neurokinin 1 Receptor Interactions [MoA]
type: Class
subclass of: G-Protein-linked Receptor Interactions [MoA]
code: C31880
Synonym: NK 1 Receptor Interactions
Display_Name: Neurokinin 1 Receptor Interactions
NUI: N0000010261
Synonym: Substance P Receptor Interactions
UMLS_CUI: C1373142
RxNorm_CUI: 984193
imported from: NDF-RT.owl

Neurokinin 1 Antagonists [MoA]
type: Class
subclass of: Neurokinin 1 Receptor Interactions [MoA]
NUI: N0000010262
UMLS_CUI: C2916827
Synonym: Substance P Receptor Antagonists
Display_Name: Neurokinin 1 Antagonists
code: C31882
RxNorm_CUI: 988216
Synonym: NK 1 Receptor Antagonists
imported from: NDF-RT.owl

Interleukin 2 Receptor Interactions [MoA]
type: Class
subclass of: Cytokine Receptor Superfamily Interactions [MoA]
NUI: N0000010278
code: C31914
UMLS_CUI: C1373153
Display_Name: Interleukin 2 Receptor Interactions
RxNorm_CUI: 984934
Synonym: IL2 Receptor Interactions
imported from: NDF-RT.owl

Interleukin 2 Receptor Antagonists [MoA]
type: Class
subclass of: Interleukin 2 Receptor Interactions [MoA]
Synonym: IL2 Receptor Antagonists
Synonym: Interleukin 2 Receptor Blockers
RxNorm_CUI: 986467
code: C31916
Display_Name: Interleukin 2 Receptor Antagonists
UMLS_CUI: C1373152
Synonym: IL2 Receptor Inhibitors
NUI: N0000010279
Synonym: Interleukin 2 Receptor Inhibitors
Synonym: IL2 Receptor Blockers
imported from: NDF-RT.owl

Hypothalmic Hormone Interactions [MoA]
type: Class
subclass of: G-Protein-linked Receptor Interactions [MoA]
NUI: N0000019992
RxNorm_CUI: 985094
code: C300377
Display_Name: Hypothalmic Hormone Interactions
UMLS_CUI: C2267109
imported from: NDF-RT.owl

Hypothalamic Hormone Receptor Agonists [MoA]
type: Class
subclass of: Hypothalmic Hormone Interactions [MoA]
RxNorm_CUI: 989569
Display_Name: Hypothalamic Hormone Receptor Agonists
code: C300378
NUI: N0000019993
UMLS_CUI: C2916835
imported from: NDF-RT.owl

Receptor Tyrosine Kinase Inhibitors [MoA]
type: Class
subclass of: Tyrosine Kinase Inhibitors [MoA]
Display_Name: Receptor Tyrosine Kinase Inhibitors
UMLS_CUI: C2267115
RxNorm_CUI: 987029
code: C300385
NUI: N0000020000
imported from: NDF-RT.owl

Tyrosine Kinase Inhibitors [MoA]
type: Class
subclass of: Protein Kinase Inhibitors [MoA]
RxNorm_CUI: 1028392
UMLS_CUI: C2757011
code: C300386
Display_Name: Tyrosine Kinase Inhibitors
NUI: N0000020001
imported from: NDF-RT.owl

HER Receptor Family Antagonists [MoA]
type: Class
subclass of: HER Receptor Family Interactions [MoA]
subclass of: Receptor Tyrosine Kinase Inhibitors [MoA]
Synonym: EGFR Family Inhibitors
Synonym: EGFR Family Antagonists
Synonym: Epidermal Growth Factor Receptor Family Antagonists
Synonym: HER Inhibitors
RxNorm_CUI: 990667
NUI: N0000020006
Display_Name: HER Receptor Family Antagonists
Synonym: Epidermal Growth Factor Receptor Family Inhibitors
Synonym: Human Epidermal Growth Factor Receptor Family Inhibitors
UMLS_CUI: C2916840
Synonym: Human Epidermal Growth Factor Receptor Family Antagonists
Synonym: HER Receptor Family Inhibitors
code: C300391
Synonym: HER Family Inhibitors
Synonym: HER Antagonists
Synonym: HER Family Antagonists
imported from: NDF-RT.owl

HER2/Neu/cerbB2 Antagonists [MoA]
type: Class
subclass of: HER Receptor Family Antagonists [MoA]
Display_Name: HER2/Neu/cerbB2 Antagonists
Synonym: HER2 Antagonists
Synonym: HER-2 Inhibitors
code: C300393
Synonym: HER2 Inhibitors
Synonym: HER2/Neu/cerbB2 Inhibitors
RxNorm_CUI: 984590
UMLS_CUI: C2916795
Synonym: HER-2 Antagonists
Synonym: HER-2/Neu/cerbB2 Antagonists
NUI: N0000020008
Synonym: HER-2/Neu/cerbB2 Inhibitors
imported from: NDF-RT.owl

Bcr-Abl Tyrosine Kinase Inhibitors [MoA]
type: Class
subclass of: Receptor Tyrosine Kinase Inhibitors [MoA]
RxNorm_CUI: 984994
code: C300394
Synonym: Bcr-Abl Tyrosine Kinase Inhibitor
NUI: N0000020009
Display_Name: Bcr-Abl Tyrosine Kinase Inhibitors
UMLS_CUI: C2267122
imported from: NDF-RT.owl

HER1 Antagonists [MoA]
type: Class
subclass of: HER Receptor Family Antagonists [MoA]
Synonym: HER1 Inhibitors
Synonym: HER-1 Antagonists
Display_Name: HER1 Antagonists
code: C300395
Synonym: Epidermal Growth Factor Receptor Antagonists
RxNorm_CUI: 989266
NUI: N0000020010
Synonym: Epidermal Growth Factor Receptor Inhibitors
Synonym: EGFR Inhibitors
Synonym: HER-1 Inhibitors
UMLS_CUI: C2916831
Synonym: EGFR Antagonists
imported from: NDF-RT.owl

Glucosyl Transferase Inhibitors [MoA]
type: Class
subclass of: Enzyme Inhibitors [MoA]
RxNorm_CUI: 988136
NUI: N0000020018
UMLS_CUI: C2267130
code: C300403
Display_Name: Glucosyl Transferase Inhibitors
imported from: NDF-RT.owl

Glucosylceramide Synthase Inhibitors [MoA]
type: Class
subclass of: Glucosyl Transferase Inhibitors [MoA]
subclass of: Restriction
  on property: realized in
  some values from: negative regulation of glucosylceramide biosynthetic process
RxNorm_CUI: 989376
code: C300404
UMLS_CUI: C2267131
Display_Name: Glucosylceramide Synthase Inhibitors
NUI: N0000020019
imported from: NDF-RT.owl

14-alpha Demethylase Inhibitors [MoA]
type: Class
subclass of: Enzyme Inhibitors [MoA]
code: C300411
UMLS_CUI: C2267137
NUI: N0000020025
RxNorm_CUI: 989952
Display_Name: 14-alpha Demethylase Inhibitors
imported from: NDF-RT.owl

Phosphodiesterase 5 Inhibitors [MoA]
type: Class
subclass of: Phosphodiesterase Inhibitors [MoA]
subclass of: Restriction
  on property: realized in
  some values from: negative regulation of cyclic-nucleotide phosphodiesterase activity
UMLS_CUI: C2267138
Synonym: Phosphodiesterase V Inhibitor
NUI: N0000020026
RxNorm_CUI: 985515
code: C300412
Synonym: Phosphodiesterase V Inhibitors
Display_Name: Phosphodiesterase 5 Inhibitors
imported from: NDF-RT.owl

L-Calcium Channel Receptor Antagonists [MoA]
type: Class
subclass of: Calcium Channel Antagonists [MoA]
subclass of: Restriction
  on property: realized in
  some values from: negative regulation of calcium ion transport
Display_Name: L-Calcium Channel Receptor Antagonists
code: C300455
RxNorm_CUI: 989377
NUI: N0000020065
UMLS_CUI: C2916833
imported from: NDF-RT.owl

Ubiquitin Ligase Inhibitors [MoA]
type: Class
subclass of: Enzyme Inhibitors [MoA]
code: C300474
UMLS_CUI: C1661195
NUI: N0000020084
RxNorm_CUI: 986156
Display_Name: Ubiquitin Ligase Inhibitors
imported from: NDF-RT.owl

Viral Envelope Interactions [MoA]
type: Class
subclass of: Immunologic and Biological Factors [MoA]
UMLS_CUI: C2267190
RxNorm_CUI: 989812
Display_Name: Viral Envelope Interactions
NUI: N0000020089
code: C300479
imported from: NDF-RT.owl

Nucleoside Synthesis Inhibitors [MoA]
type: Class
subclass of: Nucleic Acid Synthesis Inhibitors [MoA]
UMLS_CUI: C2266855
NUI: N0000175074
code: C634436
RxNorm_CUI: 987332
Display_Name: Nucleoside Synthesis Inhibitors
imported from: NDF-RT.owl

Proteasome Inhibitors [MoA]
type: Class
subclass of: Protease Inhibitors [MoA]
code: C634437
NUI: N0000175075
RxNorm_CUI: 988088
Display_Name: Proteasome Inhibitors
Synonym: Proteosome Inhibitors
UMLS_CUI: C2266856
Synonym: Proteasome Inhibitor
imported from: NDF-RT.owl

Protein Kinase Inhibitors [MoA]
type: Class
subclass of: Kinase Inhibitors [MoA]
code: C634438
Display_Name: Protein Kinase Inhibitors
RxNorm_CUI: 993161
NUI: N0000175076
UMLS_CUI: C2757016
imported from: NDF-RT.owl

Kinase Inhibitors [MoA]
type: Class
subclass of: Enzyme Inhibitors [MoA]
RxNorm_CUI: 1025684
Display_Name: Kinase Inhibitors
NUI: N0000175082
code: C634444
UMLS_CUI: C1152564
imported from: NDF-RT.owl

Binding Activity [MoA]
type: Class
subclass of: Physiochemical Activity [MoA]
UMLS_CUI: C2266866
Display_Name: Binding Activity
NUI: N0000175355
code: C634738
RxNorm_CUI: 990338
imported from: NDF-RT.owl

Cholinergic Interactions [MoA]
type: Class
subclass of: Receptor Interactions [MoA]
code: C634751
Display_Name: Cholinergic Interactions
UMLS_CUI: C2266879
NUI: N0000175368
RxNorm_CUI: 987379
imported from: NDF-RT.owl

Cholinergic Agonists [MoA]
type: Class
subclass of: Cholinergic Interactions [MoA]
code: C634752
NUI: N0000175369
UMLS_CUI: C2757066
Display_Name: Cholinergic Agonists
RxNorm_CUI: 1033063
imported from: NDF-RT.owl

Tumor Necrosis Factor alpha Receptor Blocking Activity [MoA]
type: Class
subclass of: Tumor Necrosis Factor Receptor Blocking Activity [MoA]
subclass of: Restriction
  on property: realized in
  some values from: negative regulation of tumor necrosis factor-mediated signaling pathway
UMLS_CUI: C2267209
Synonym: TNF-a Receptor Blocking Activity
RxNorm_CUI: 988325
NUI: N0000175446
Display_Name: Tumor Necrosis Factor alpha Receptor Blocking Activity
code: C30270
Synonym: TNF-alpha Receptor Blocking Activity
imported from: NDF-RT.owl

Corticosteroid Hormone Receptor Agonists [MoA]
type: Class
subclass of: Steroid Hormone Receptor Agonists [MoA]
code: C634830
UMLS_CUI: C2266939
Display_Name: Corticosteroid Hormone Receptor Agonists
RxNorm_CUI: 988660
NUI: N0000175450
imported from: NDF-RT.owl

Tumor Necrosis Factor Receptor Blocking Activity [MoA]
type: Class
subclass of: Tumor Necrosis Factor Receptor Interactions [MoA]
NUI: N0000175451
code: C634831
Synonym: TNF Blocker
Synonym: TNF Receptor Blocking Activity
Display_Name: Tumor Necrosis Factor Receptor Blocking Activity
RxNorm_CUI: 984952
UMLS_CUI: C2266940
imported from: NDF-RT.owl

Metal Chelating Activity [MoA]
type: Class
subclass of: Chelating Activity [MoA]
code: C634853
NUI: N0000175472
UMLS_CUI: C1154714
Display_Name: Metal Chelating Activity
RxNorm_CUI: 986481
imported from: NDF-RT.owl

Cholesterol Synthesis Inhibitors [MoA]
type: Class
subclass of: Sterol Synthesis Inhibitors [MoA]
UMLS_CUI: C2917205
RxNorm_CUI: 991925
NUI: N0000175919
Display_Name: Cholesterol Synthesis Inhibitors
code: C635357
imported from: NDF-RT.owl

entity
type: Class
BFO OWL specification label: entity
editor note: BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81
BFO CLIF specification label: Entity
elucidation: An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001])
editor note: Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf
example of usage: Julius Caesar
example of usage: Verdi’s Requiem
example of usage: the Second World War
example of usage: your body mass index
imported from: bfo.owl
imported from: oae.owl
imported from: obi.owl
imported from: ogms.owl

continuant
type: Class
subclass of: entity
BFO OWL specification label: continuant
BFO CLIF specification label: Continuant
has associated axiom(fol): (forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002]
has associated axiom(fol): (forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002]
has associated axiom(fol): (forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002]
has associated axiom(fol): (forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001]
elucidation: A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002])
editor note: BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240
editor note: Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants
has associated axiom(nl): if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001])
has associated axiom(nl): if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002])
has associated axiom(nl): if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002])
imported from: bfo.owl
imported from: oae.owl
imported from: obi.owl

occurrent
type: Class
subclass of: entity
has associated axiom(fol): (forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001]
editor note: Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame.
has associated axiom(fol): (forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001]
elucidation: An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002])
editor note: BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region
editor note: BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players.
BFO CLIF specification label: Occurrent
editor note: Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process.
has associated axiom(nl): b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001])
BFO OWL specification label: occurrent
has associated axiom(nl): Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001])
imported from: bfo.owl
imported from: oae.owl
imported from: obi.owl

independent continuant
type: Class
subclass of: continuant
BFO CLIF specification label: IndependentContinuant
has associated axiom(fol): (forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002]
has associated axiom(fol): (iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002]
has associated axiom(fol): (forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001]
has associated axiom(nl): For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001])
has associated axiom(nl): For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002])
example of usage: a heart
example of usage: a molecule
BFO OWL specification label: ic
example of usage: a chair
example of usage: a leg
example of usage: a spatial region
example of usage: an atom
example of usage: an orchestra.
example of usage: an organism
definition: b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])
example of usage: the bottom right portion of a human torso
example of usage: the interior of your mouth
imported from: bfo.owl
imported from: oae.owl
imported from: obi.owl

process
type: Class
subclass of: occurrent
BFO CLIF specification label: Process
has associated axiom(fol): (iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003]
editor note: BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war)
example of usage: a process of cell-division, \ a beating of the heart
example of usage: a process of meiosis
example of usage: a process of sleeping
definition: p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])
BFO OWL specification label: process
example of usage: the course of a disease
example of usage: the flight of a bird
example of usage: the life of an organism
example of usage: your process of aging.
imported from: bfo.owl
imported from: oae.owl

disposition
type: Class
subclass of: realizable entity
has associated axiom(fol): (forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002]
editor note: BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type.
BFO CLIF specification label: Disposition
has associated axiom(fol): (forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002]
BFO OWL specification label: disposition
has associated axiom(nl): If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002])
example of usage: an atom of element X has the disposition to decay to an atom of element Y
elucidation: b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002])
example of usage: certain people have a predisposition to colon cancer
example of usage: children are innately disposed to categorize objects in certain ways.
example of usage: the cell wall is disposed to filter chemicals in endocytosis and exocytosis
imported from: bfo.owl
imported from: oae.owl

realizable entity
type: Class
subclass of: specifically dependent continuant
has associated axiom(fol): (forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002]
has associated axiom(fol): (forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002]
has associated axiom(nl): All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002])
BFO CLIF specification label: RealizableEntity
elucidation: To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002])
BFO OWL specification label: realizable
example of usage: the disposition of this piece of metal to conduct electricity.
example of usage: the disposition of your blood to coagulate
example of usage: the function of your reproductive organs
example of usage: the role of being a doctor
example of usage: the role of this boundary to delineate where Utah and Colorado meet
imported from: bfo.owl
imported from: oae.owl
imported from: obi.owl

quality
type: Class
subclass of: specifically dependent continuant
has associated axiom(fol): (forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001]
BFO OWL specification label: quality
BFO CLIF specification label: Quality
has associated axiom(fol): (forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001]
has associated axiom(nl): If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001])
elucidation: a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001])
example of usage: the ambient temperature of this portion of air
example of usage: the color of a tomato
example of usage: the length of the circumference of your waist
example of usage: the mass of this piece of gold.
example of usage: the shape of your nose
example of usage: the shape of your nostril
imported from: bfo.owl
imported from: oae.owl

specifically dependent continuant
type: Class
subclass of: continuant
has associated axiom(fol): (iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003]
has associated axiom(fol): (iff (RelationalSpecificallyDependentContinuant a) (and (SpecificallyDependentContinuant a) (forall (t) (exists (b c) (and (not (SpatialRegion b)) (not (SpatialRegion c)) (not (= b c)) (not (exists (d) (and (continuantPartOfAt d b t) (continuantPartOfAt d c t)))) (specificallyDependsOnAt a b t) (specificallyDependsOnAt a c t)))))) // axiom label in BFO2 CLIF: [131-004]
BFO CLIF specification label: SpecificallyDependentContinuant
example of usage: Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key
editor note: Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc.
definition: b is a relational specifically dependent continuant = Def. b is a specifically dependent continuant and there are n > 1 independent continuants c1, … cn which are not spatial regions are such that for all 1 i < j n, ci and cj share no common parts, are such that for each 1 i n, b s-depends_on ci at every time t during the course of b’s existence (axiom label in BFO2 Reference: [131-004])
definition: b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])
example of usage: of one-sided specifically dependent continuants: the mass of this tomato
example of usage: of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates.
BFO OWL specification label: sdc
example of usage: the disposition of this fish to decay
example of usage: the function of this heart: to pump blood
example of usage: the mutual dependence of proton donors and acceptors in chemical reactions [79
example of usage: the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction
example of usage: the pink color of a medium rare piece of grilled filet mignon at its center
example of usage: the role of being a doctor
example of usage: the shape of this hole.
example of usage: the smell of this portion of mozzarella
imported from: bfo.owl
imported from: oae.owl
imported from: obi.owl

role
type: Class
subclass of: realizable entity
BFO CLIF specification label: Role
BFO OWL specification label: role
has associated axiom(fol): (forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001]
editor note: BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals – professor, sergeant, nurse – only during certain phases in their lives.
example of usage: John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married.
elucidation: b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001])
example of usage: the priest role
example of usage: the role of a boundary to demarcate two neighboring administrative territories
example of usage: the role of a building in serving as a military target
example of usage: the role of a stone in marking a property boundary
example of usage: the role of subject in a clinical trial
example of usage: the student role
imported from: bfo.owl
imported from: oae.owl
imported from: obi.owl

object
type: Class
subclass of: material entity
BFO OWL specification label: object
BFO CLIF specification label: Object
editor note: BFO 2 Reference: BFO rests on the presupposition that at multiple micro-, meso- and macroscopic scales reality exhibits certain stable, spatially separated or separable material units, combined or combinable into aggregates of various sorts (for example organisms into what are called ‘populations’). Such units play a central role in almost all domains of natural science from particle physics to cosmology. Many scientific laws govern the units in question, employing general terms (such as ‘molecule’ or ‘planet’) referring to the types and subtypes of units, and also to the types and subtypes of the processes through which such units develop and interact. The division of reality into such natural units is at the heart of biological science, as also is the fact that these units may form higher-level units (as cells form multicellular organisms) and that they may also form aggregates of units, for example as cells form portions of tissue and organs form families, herds, breeds, species, and so on. At the same time, the division of certain portions of reality into engineered units (manufactured artifacts) is the basis of modern industrial technology, which rests on the distributed mass production of engineered parts through division of labor and on their assembly into larger, compound units such as cars and laptops. The division of portions of reality into units is one starting point for the phenomenon of counting.
editor note: BFO 2 Reference: Each object is such that there are entities of which we can assert unproblematically that they lie in its interior, and other entities of which we can assert unproblematically that they lie in its exterior. This may not be so for entities lying at or near the boundary between the interior and exterior. This means that two objects – for example the two cells depicted in Figure 3 – may be such that there are material entities crossing their boundaries which belong determinately to neither cell. Something similar obtains in certain cases of conjoined twins (see below).
editor note: BFO 2 Reference: To say that b is causally unified means: b is a material entity which is such that its material parts are tied together in such a way that, in environments typical for entities of the type in question,if c, a continuant part of b that is in the interior of b at t, is larger than a certain threshold size (which will be determined differently from case to case, depending on factors such as porosity of external cover) and is moved in space to be at t at a location on the exterior of the spatial region that had been occupied by b at t, then either b’s other parts will be moved in coordinated fashion or b will be damaged (be affected, for example, by breakage or tearing) in the interval between t and t.causal changes in one part of b can have consequences for other parts of b without the mediation of any entity that lies on the exterior of b. Material entities with no proper material parts would satisfy these conditions trivially. Candidate examples of types of causal unity for material entities of more complex sorts are as follows (this is not intended to be an exhaustive list):CU1: Causal unity via physical coveringHere the parts in the interior of the unified entity are combined together causally through a common membrane or other physical covering\. The latter points outwards toward and may serve a protective function in relation to what lies on the exterior of the entity [13, 47
editor note: BFO 2 Reference: an object is a maximal causally unified material entity
editor note: BFO 2 Reference: ‘objects’ are sometimes referred to as ‘grains’ [74
example of usage: atom
elucidation: b is an object means: b is a material entity which manifests causal unity of one or other of the types CUn listed above & is of a type (a material universal) instances of which are maximal relative to this criterion of causal unity. (axiom label in BFO2 Reference: [024-001])
example of usage: cell
example of usage: cells and organisms
example of usage: engineered artifacts
example of usage: grain of sand
example of usage: molecule
example of usage: organelle
example of usage: organism
example of usage: planet
example of usage: solid portions of matter
example of usage: star
imported from: bfo.owl
imported from: oae.owl
imported from: uberon.owl

generically dependent continuant
type: Class
subclass of: continuant
BFO OWL specification label: gdc
has associated axiom(fol): (iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001]
BFO CLIF specification label: GenericallyDependentContinuant
example of usage: The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity.
definition: b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])
example of usage: the pdf file on your laptop, the pdf file that is a copy thereof on my laptop
example of usage: the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule.
imported from: bfo.owl
imported from: oae.owl

material entity
type: Class
subclass of: independent continuant
BFO OWL specification label: material
has associated axiom(fol): (forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002]
has associated axiom(fol): (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002]
has associated axiom(fol): (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002]
elucidation: A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002])
editor note: BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60
editor note: BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity.
editor note: BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here.
has associated axiom(nl): Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002])
BFO CLIF specification label: MaterialEntity
example of usage: a flame
example of usage: a forest fire
example of usage: a human being
example of usage: a hurricane
example of usage: a photon
example of usage: a puff of smoke
example of usage: a sea wave
example of usage: a tornado
example of usage: an aggregate of human beings.
example of usage: an energy wave
example of usage: an epidemic
has associated axiom(nl): every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002])
example of usage: the undetached arm of a human being
imported from: bfo.owl
imported from: oae.owl
imported from: obi.owl
imported from: uberon.owl

voriconazole
type: Class
subclass of: triazoles
subclass of: organofluorine compound
subclass of: pyrimidines
has_exact_synonym: (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
has_related_synonym: (R-(R*,S*))-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol
has_related_synonym: (alphaR,betaS)-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol
has_RxCUI: 121243
definition: A triazole-based antifungal agent used for the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp.
database_cross_reference: Beilstein:7694998
has_related_synonym: C16H14F3N5O
id: CHEBI:10023
has_alternative_id: CHEBI:127308
database_cross_reference: ChEMBL:127308
database_cross_reference: ChemIDplus:137234-62-9
database_cross_reference: DrugBank:137234-62-9
database_cross_reference: DrugBank:DB00582
has_related_synonym: InChI=1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1
has_related_synonym: InChIKey=BCEHBSKCWLPMDN-MGPLVRAMSA-N
database_cross_reference: KEGG COMPOUND:137234-62-9
database_cross_reference: KEGG COMPOUND:C07622
database_cross_reference: KEGG DRUG:137234-62-9
database_cross_reference: KEGG DRUG:D00578
database_cross_reference: Patent:EP440372
database_cross_reference: Patent:US5278175
has_related_synonym: VCZ
has_related_synonym: Vfend
database_cross_reference: Wikipedia:Voriconazole
has_related_synonym: voriconazole
imported from: dron.owl

Ciprofloxacin
type: Class
label: ciprofloxacin
subclass of: quinolone
subclass of: quinolinemonocarboxylic acid
subclass of: aminoquinoline
subclass of: organofluorine compound
subclass of: N-arylpiperazine
has_related_synonym: 1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID
has_related_synonym: 1-Cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid
has_related_synonym: 1-Cyclopropyl-6-fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid
has_related_synonym: 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
has_exact_synonym: 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
has_related_synonym: 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
has_related_synonym: 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid
has_related_synonym: 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid
has_related_synonym: 1-cyclopropyl-6-fluoro-7-hexahydro-1-pyrazinyl-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid
has_RxCUI: 2551
database_cross_reference: Beilstein:3568352
has_related_synonym: C17H18FN3O3
id: CHEBI:100241
has_alternative_id: CHEBI:102718
has_alternative_id: CHEBI:3717
has_alternative_id: CHEBI:41638
database_cross_reference: ChEMBL:100241
database_cross_reference: ChEMBL:102718
database_cross_reference: ChEMBL:10397494
database_cross_reference: ChEMBL:10737746
database_cross_reference: ChemIDplus:85721-33-1
has_exact_synonym: Ciprofloxacin
database_cross_reference: DrugBank:DB00537
has_related_synonym: InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24)
has_related_synonym: InChIKey=MYSWGUAQZAJSOK-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:85721-33-1
database_cross_reference: KEGG DRUG:D00186
database_cross_reference: Patent:DE3142854
database_cross_reference: Patent:US4670444
definition: Quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.
database_cross_reference: Wikipedia:Ciprofloxacin
has_exact_synonym: ciprofloxacin
has_related_synonym: ciprofloxacin
has_related_synonym: ciprofloxacine
has_related_synonym: ciprofloxacino
has_related_synonym: ciprofloxacinum
imported from: dron.owl

Norfloxacin
type: Class
label: norfloxacin
subclass of: quinolone
subclass of: quinolinemonocarboxylic acid
subclass of: organofluorine compound
subclass of: N-arylpiperazine
has_related_synonym: 1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
has_related_synonym: 1-Ethyl-6-fluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-chinolincarbonsaeure
has_related_synonym: 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
has_exact_synonym: 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
has_RxCUI: 7517
definition: A synthetic fluoroquinolone with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase.
database_cross_reference: Beilstein:567897
has_related_synonym: C16H18FN3O3
id: CHEBI:100246
has_alternative_id: CHEBI:7629
database_cross_reference: ChEMBL:100246
database_cross_reference: ChemIDplus:70458-96-7
database_cross_reference: CiteXplore:3317294
database_cross_reference: CiteXplore:3908074
database_cross_reference: CiteXplore:6211142
database_cross_reference: CiteXplore:6224685
database_cross_reference: CiteXplore:6234465
database_cross_reference: CiteXplore:6454381
database_cross_reference: CiteXplore:6461606
database_cross_reference: DrugBank:DB01059
database_cross_reference: Gmelin:1576626
has_related_synonym: InChI=1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)
has_related_synonym: InChIKey=OGJPXUAPXNRGGI-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:70458-96-7
database_cross_reference: KEGG COMPOUND:C06687
database_cross_reference: KEGG DRUG:D00210
has_related_synonym: NFLX
database_cross_reference: Patent:BE863429
database_cross_reference: Patent:DE2840910
database_cross_reference: Patent:US4146719
database_cross_reference: Patent:US4292317
database_cross_reference: Wikipedia:Norfloxacin
has_related_synonym: norfloxacin
has_related_synonym: norfloxacine
has_related_synonym: norfloxacino
has_related_synonym: norfloxacinum
imported from: dron.owl

zafirlukast
type: Class
subclass of: carbamate ester
subclass of: indoles
subclass of: sulfonamide
has_RxCUI: 114970
has_related_synonym: 4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol-3-ylmethyl)-3-methoxy-N-o-tolylsulfonylbenzamide
has_related_synonym: Accolate
definition: An indole that has formula C31H33N3O6S.
database_cross_reference: Beilstein:3641829
has_related_synonym: C31H33N3O6S
id: CHEBI:10100
database_cross_reference: ChemIDplus:107753-78-6
database_cross_reference: DrugBank:DB00549
has_related_synonym: InChI=1S/C31H33N3O6S/c1-20-8-4-7-11-29(20)41(37,38)33-30(35)22-13-12-21(28(17-22)39-3)16-23-19-34(2)27-15-14-24(18-26(23)27)32-31(36)40-25-9-5-6-10-25/h4,7-8,11-15,17-19,25H,5-6,9-10,16H2,1-3H3,(H,32,36)(H,33,35)
has_related_synonym: InChIKey=YEEZWCHGZNKEEK-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:107753-78-6
database_cross_reference: KEGG COMPOUND:C07206
database_cross_reference: KEGG DRUG:D00411
database_cross_reference: Wikipedia:Zafirlukast
has_related_synonym: cyclopentyl 3-(2-methoxy-4-((o-tolylsulfonyl)carbamoyl)benzyl)-1-methylindole-5-carbamate
has_exact_synonym: cyclopentyl 3-[2-methoxy-4-(2-methylphenylsulfonylcarbamoyl)benzyl]-1-methyl-1H-indol-5-ylcarbamate
has_related_synonym: zafirlukast
imported from: dron.owl

zaleplon
type: Class
subclass of: nitrile
subclass of: pyrazolopyrimidine
has_related_synonym: 3'-(3-Cyanopyrazolo(1,5-a)pyrimidin-7-yl)-N-ethylacetanilide
has_RxCUI: 74667
definition: A pyrazolo[1,5-a]pyrimidine having a nitrile group at position 3 and a 3-(N-ethylacetamido)phenyl substituent at the 7-position.
database_cross_reference: Beilstein:8153844
has_related_synonym: C17H15N5O
has_related_synonym: CCN(C(C)=O)c1cccc(c1)-c1ccnc2c(cnn12)C#N
id: CHEBI:10102
database_cross_reference: ChemIDplus:151319-34-5
database_cross_reference: DrugBank:151319-34-5
database_cross_reference: DrugBank:DB00962
has_related_synonym: InChI=1S/C17H15N5O/c1-3-21(12(2)23)15-6-4-5-13(9-15)16-7-8-19-17-14(10-18)11-20-22(16)17/h4-9,11H,3H2,1-2H3
has_related_synonym: InChIKey=HUNXMJYCHXQEGX-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:151319-34-5
database_cross_reference: KEGG COMPOUND:C07484
database_cross_reference: KEGG DRUG:151319-34-5
database_cross_reference: KEGG DRUG:D00530
has_exact_synonym: N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide
database_cross_reference: NIST Chemistry WebBook:151319-34-5
database_cross_reference: Patent:US4626538
database_cross_reference: Wikipedia:Zaleplon
has_related_synonym: zaleplon
imported from: dron.owl

Zidovudine
type: Class
label: zidovudine
subclass of: azides
subclass of: pyrimidine 2',3'-dideoxyribonucleoside
has_RxCUI: 11413
has_exact_synonym: 3'-azido-3'-deoxythymidine
definition: A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.
has_related_synonym: AZT
has_related_synonym: Azidothymidine
database_cross_reference: Beilstein:763034
has_related_synonym: C10H13N5O4
id: CHEBI:10110
has_alternative_id: CHEBI:619601
has_related_synonym: Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O
database_cross_reference: ChEMBL:19112024
database_cross_reference: ChEMBL:619601
database_cross_reference: ChemIDplus:30516-87-1
database_cross_reference: DrugBank:30516-87-1
database_cross_reference: DrugBank:DB00495
has_related_synonym: InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
has_related_synonym: InChIKey=HBOMLICNUCNMMY-XLPZGREQSA-N
database_cross_reference: KEGG COMPOUND:30516-87-1
database_cross_reference: KEGG COMPOUND:C07210
database_cross_reference: KEGG DRUG:30516-87-1
database_cross_reference: KEGG DRUG:D00413
database_cross_reference: Patent:US4724232
database_cross_reference: Wikipedia:Zidovudine
has_related_synonym: Zidovudin
has_related_synonym: Zidovudinum
has_related_synonym: zidovudine
imported from: dron.owl

ziprasidone
type: Class
subclass of: indolones
subclass of: piperazines
subclass of: organochlorine compound
subclass of: 1,2-thiazole
has_RxCUI: 115698
has_exact_synonym: 5-{2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl}-6-chloro-1,3-dihydro-2H-indol-2-one
definition: A piperazine compound having 1,2-benzothiazol-3-yl- and 2-(6-chloro-1,3-dihydro-2-oxindol-5-yl)ethyl substituents attached to the nitrogen atoms.
database_cross_reference: Beilstein:6669199
has_related_synonym: C21H21ClN4OS
id: CHEBI:10119
database_cross_reference: ChemIDplus:146939-27-7
database_cross_reference: DrugBank:146939-27-7
database_cross_reference: DrugBank:DB00246
has_related_synonym: InChI=1S/C21H21ClN4OS/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21/h1-4,11,13H,5-10,12H2,(H,23,27)
has_related_synonym: InChIKey=MVWVFYHBGMAFLY-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:C07568
database_cross_reference: KEGG DRUG:146939-27-7
database_cross_reference: KEGG DRUG:D08687
database_cross_reference: Patent:EP281309
database_cross_reference: Patent:US4831031
database_cross_reference: Wikipedia:Ziprasidone
has_exact_synonym: Ziprasidone
has_related_synonym: ziprasidona
has_related_synonym: ziprasidone
has_related_synonym: ziprasidonum
imported from: dron.owl

zolpidem
type: Class
subclass of: imidazopyridine
has_RxCUI: 39993
definition: An imidazo[1,2-a]pyridine compound having a 4-tolyl group at the 2-position, an N,N-dimethylcarbamoylmethyl group at the 3-position and a methyl substituent at the 6-position.
database_cross_reference: Beilstein:4355785
has_related_synonym: C19H21N3O
id: CHEBI:10125
has_related_synonym: CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1
database_cross_reference: ChemIDplus:82626-48-0
database_cross_reference: DrugBank:82626-48-0
database_cross_reference: DrugBank:DB00425
has_related_synonym: InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3
has_related_synonym: InChIKey=ZAFYATHCZYHLPB-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:82626-48-0
database_cross_reference: KEGG COMPOUND:C07219
database_cross_reference: KEGG DRUG:82626-48-0
database_cross_reference: KEGG DRUG:D08690
has_related_synonym: N,N,6-Trimethyl-2-(4-methylphenyl)imidazo(1,2-a)pyridine-3-acetamide
has_exact_synonym: N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide
database_cross_reference: NIST Chemistry WebBook:82626-48-0
database_cross_reference: Patent:EP50563
database_cross_reference: Patent:US4382938
database_cross_reference: Wikipedia:Zolpidem
has_related_synonym: zolpidem
has_related_synonym: zolpidemum
imported from: dron.owl

zonisamide
type: Class
subclass of: sulfonamide
subclass of: 1,2-benzoxazoles
has_related_synonym: 1,2-Benzisoxazole-3-methanesulfonamide
has_exact_synonym: 1-(1,2-benzisoxazol-3-yl)methanesulfonamide
has_related_synonym: 3-(Sulfamoylmethyl)-1,2-benzisoxazole
has_RxCUI: 39998
definition: A 1,2-benzoxazole compound having a sulfamoylmethyl substituent at the 3-position.
database_cross_reference: Beilstein:1077076
has_related_synonym: Benzo[d]isoxazol-3-yl-methanesulfonamide
has_related_synonym: C8H8N2O3S
id: CHEBI:10127
has_alternative_id: CHEBI:139857
database_cross_reference: ChEMBL:139857
database_cross_reference: ChemIDplus:68291-97-4
database_cross_reference: DrugBank:68291-97-4
database_cross_reference: DrugBank:DB00909
has_related_synonym: InChI=1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12)
has_related_synonym: InChIKey=UBQNRHZMVUUOMG-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:68291-97-4
database_cross_reference: KEGG COMPOUND:C07504
database_cross_reference: KEGG DRUG:68291-97-4
database_cross_reference: KEGG DRUG:D00538
has_related_synonym: NS(=O)(=O)Cc1noc2ccccc12
database_cross_reference: Patent:JP7877057
database_cross_reference: Patent:US4172896
database_cross_reference: Wikipedia:Zonisamide
has_related_synonym: zonisamida
has_related_synonym: zonisamide
has_related_synonym: zonisamidum
imported from: dron.owl

Diltiazem
type: Class
label: diltiazem
subclass of: benzothiazepine
subclass of: Restriction
  on property: is_bearer_of
  some values from: function-inhibiting L-type voltage-gated calcium channel binding disposition
has_related_synonym: (+)-cis-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ester
has_related_synonym: (2S,3S)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate
has_exact_synonym: (2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate
has_related_synonym: (2S-cis)-3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
has_RxCUI: 3443
has_related_synonym: Acetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester
database_cross_reference: Beilstein:3573079
has_related_synonym: C22H26N2O4S
id: CHEBI:101278
has_alternative_id: CHEBI:4602
database_cross_reference: ChEMBL:101278
database_cross_reference: ChemIDplus:42399-41-7
has_exact_synonym: DILTIAZEM
has_exact_synonym: Diltiazem
database_cross_reference: DrugBank:DB00343
has_related_synonym: InChI=1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m1/s1
has_related_synonym: InChIKey=HSUGRBWQSSZJOP-RTWAWAEBSA-N
database_cross_reference: KEGG COMPOUND:42399-41-7
database_cross_reference: KEGG COMPOUND:C06958
database_cross_reference: KEGG DRUG:D07845
database_cross_reference: NIST Chemistry WebBook:42399-41-7
database_cross_reference: Patent:DE1805714
database_cross_reference: Patent:DE3415035
database_cross_reference: Patent:US3562257
database_cross_reference: Patent:US4552695
definition: The (S,S)-diastereoisomer of 2,3-dihydro-1,5-benzothiazepin-4(5H)-one in which positions 2 and 3 are substituted by 4-methoxyphenyl and acetoxy, respectively, while the hydrogen attached to the nitrogen is substituted by a 2-(dimethylamino)ethyl group. A calcium-channel blocker and vasodilator, it is used as the hydrochloride in the management of angina pectoris and hypertension.
database_cross_reference: Wikipedia:Diltiazem
has_related_synonym: diltiazem
has_related_synonym: diltiazemum
imported from: dron.owl

butalbital
type: Class
subclass of: barbiturates
has_RxCUI: 19860
has_exact_synonym: 5-(2-methylpropyl)-5-(prop-2-en-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione
has_related_synonym: 5-(2-methylpropyl)-5-prop-2-enyl-1,3-diazinane-2,4,6-trione
has_related_synonym: 5-Allyl-5-isobutyl-pyrimidine-2,4,6-trione
has_related_synonym: 5-allyl-5-(2'-methyl-n-propyl) barbituric acid
has_related_synonym: 5-allyl-5-(2-methylpropyl)barbituric acid
has_related_synonym: 5-allyl-5-isobutyl-2,4,6(1H,3H,5H)-pyrimidinetrione
has_related_synonym: 5-allyl-5-isobutylbarbituric acid
has_related_synonym: 5-isobutyl-5-allylbarbituric acid
definition: Barbituric acid in which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. Frequently combined with other medicines, such as aspirin, paracetamol and codeine, it is used for treatment of pain and headache.
database_cross_reference: Beilstein:202119
has_related_synonym: C11H16N2O3
has_related_synonym: CC(C)CC1(CC=C)C(=O)NC(=O)NC1=O
id: CHEBI:102524
database_cross_reference: ChEMBL:102524
database_cross_reference: ChEMBL:6864729
database_cross_reference: ChemIDplus:77-26-9
database_cross_reference: DrugBank:DB00241
has_related_synonym: InChI=1S/C11H16N2O3/c1-4-5-11(6-7(2)3)8(14)12-10(16)13-9(11)15/h4,7H,1,5-6H2,2-3H3,(H2,12,13,14,15,16)
has_related_synonym: InChIKey=UZVHFVZFNXBMQJ-UHFFFAOYSA-N
database_cross_reference: KEGG DRUG:D03182
database_cross_reference: NIST Chemistry WebBook:77-26-9
database_cross_reference: Wikipedia:Butalbital
has_related_synonym: allylbarbital
has_related_synonym: allylbarbitone
has_related_synonym: allylbarbituric acid
has_related_synonym: butalbarbital
has_related_synonym: butalbital
has_related_synonym: butalbitalum
has_related_synonym: iso-butylallylbarbituric acid
has_related_synonym: itobarbital
has_related_synonym: tetrallobarbital
imported from: dron.owl

Sumatriptan
type: Class
label: sumatriptan
subclass of: tryptamines
subclass of: sulfonamide
has_related_synonym: (3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methylmethanesulfonamide
has_related_synonym: 1-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-N-methyl-methanesulfonamide
has_exact_synonym: 1-{3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}-N-methylmethanesulfonamide
has_related_synonym: 3-(2-(dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide
has_related_synonym: 3-[2-(dimethylamino)ethyl]-N-methylindole-5-methanesulfonamide
has_RxCUI: 37418
definition: A sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family).
database_cross_reference: Beilstein:5346011
has_related_synonym: C14H21N3O2S
id: CHEBI:10650
has_related_synonym: CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1
database_cross_reference: ChemIDplus:103628-46-2
database_cross_reference: CiteXplore:11045888
database_cross_reference: CiteXplore:11401410
database_cross_reference: CiteXplore:12172708
database_cross_reference: CiteXplore:12856385
database_cross_reference: CiteXplore:12917936
database_cross_reference: CiteXplore:15652399
database_cross_reference: CiteXplore:16120224
database_cross_reference: CiteXplore:16142613
database_cross_reference: CiteXplore:17557349
database_cross_reference: CiteXplore:18442019
database_cross_reference: CiteXplore:19619527
database_cross_reference: CiteXplore:19825906
database_cross_reference: CiteXplore:22106962
database_cross_reference: CiteXplore:22150557
database_cross_reference: CiteXplore:22272067
database_cross_reference: CiteXplore:22302025
database_cross_reference: CiteXplore:22336849
database_cross_reference: CiteXplore:22336867
database_cross_reference: CiteXplore:22336868
database_cross_reference: CiteXplore:22435741
database_cross_reference: DrugBank:DB00669
database_cross_reference: HMDB:HMDB05037
has_related_synonym: Imigran
has_related_synonym: Imitrex
has_related_synonym: InChI=1S/C14H21N3O2S/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3/h4-5,8-9,15-16H,6-7,10H2,1-3H3
has_related_synonym: InChIKey=KQKPFRSPSRPDEB-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:103628-46-2
database_cross_reference: KEGG COMPOUND:C07319
database_cross_reference: KEGG DRUG:D00451
database_cross_reference: NIST Chemistry WebBook:103628-46-2
database_cross_reference: Reaxys:5346011
has_related_synonym: Sumatran
has_related_synonym: Sumax
database_cross_reference: Wikipedia:Sumatriptan
has_related_synonym: sumatriptan
has_related_synonym: sumatriptanum
imported from: dron.owl

Fentanyl
type: Class
label: fentanyl
subclass of: anilide
subclass of: piperidines
subclass of: carboxamide
has_related_synonym: 1-phenethyl-4-(N-phenylpropionamido)piperidine
has_related_synonym: 1-phenethyl-4-N-propionylanilinopiperidine
has_RxCUI: 4337
has_related_synonym: C22H28N2O
has_related_synonym: CCC(=O)N(C1CCN(CC1)CCc1ccccc1)c1ccccc1
id: CHEBI:119915
has_alternative_id: CHEBI:310077
has_alternative_id: CHEBI:5012
database_cross_reference: ChEMBL:10669565
database_cross_reference: ChEMBL:10987438
database_cross_reference: ChEMBL:11585443
database_cross_reference: ChEMBL:119915
database_cross_reference: ChEMBL:14698188
database_cross_reference: ChEMBL:310077
database_cross_reference: ChemIDplus:437-38-7
database_cross_reference: CiteXplore:16621415
database_cross_reference: DrugBank:DB00813
has_exact_synonym: FENTANYL
has_related_synonym: InChI=1S/C22H28N2O/c1-2-22(25)24(20-11-7-4-8-12-20)21-14-17-23(18-15-21)16-13-19-9-5-3-6-10-19/h3-12,21H,2,13-18H2,1H3
has_related_synonym: InChIKey=PJMPHNIQZUBGLI-UHFFFAOYSA-N
database_cross_reference: KEGG DRUG:437-38-7
database_cross_reference: KEGG DRUG:D00320
has_related_synonym: N-(1-Phenethyl-piperidin-4-yl)-N-phenyl-propionamide
has_related_synonym: N-(1-phenethyl-4-piperidinyl)-N-phenylpropionamide
has_related_synonym: N-(1-phenethyl-4-piperidyl)propionanilide
has_related_synonym: N-(1-phenethylpiperidin-4-yl)-N-phenylpropionamide
has_related_synonym: N-phenethyl-4-(N-propionylanilino)piperidine
has_related_synonym: N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)propanamide
has_exact_synonym: N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
database_cross_reference: Patent:FR1344366
database_cross_reference: Patent:US3164600
database_cross_reference: Reaxys:494484
definition: The carboxamide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
database_cross_reference: Wikipedia:Fentanyl
has_related_synonym: fentanila
has_related_synonym: fentanyl
has_related_synonym: fentanylum
imported from: dron.owl

Foscarnet
type: Class
label: phosphonoformic acid
subclass of: phosphonic acids
subclass of: carboxylic acid
has_RxCUI: 33562
has_related_synonym: CH3O5P
id: CHEBI:127780
has_alternative_id: CHEBI:45085
has_alternative_id: CHEBI:8158
database_cross_reference: ChEMBL:127780
database_cross_reference: ChemIDplus:4428-95-9
database_cross_reference: CiteXplore:11576919
database_cross_reference: CiteXplore:15182735
database_cross_reference: CiteXplore:16858125
database_cross_reference: CiteXplore:19213941
database_cross_reference: CiteXplore:19288498
database_cross_reference: CiteXplore:21056575
database_cross_reference: CiteXplore:21566148
database_cross_reference: DrugBank:DB00529
has_related_synonym: FOSCARNET
has_related_synonym: Foscarmet
has_related_synonym: InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)
has_related_synonym: InChIKey=ZJAOAACCNHFJAH-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:4428-95-9
database_cross_reference: KEGG COMPOUND:C06456
has_related_synonym: OC(=O)P(O)(O)=O
database_cross_reference: PDBeChem:PPF
has_exact_synonym: PHOSPHONOFORMIC ACID
definition: Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.
database_cross_reference: Reaxys:1756501
database_cross_reference: Wikipedia:Foscarnet
has_related_synonym: carboxyphosphonic acid
has_exact_synonym: dihydroxyphosphanecarboxylic acid oxide
has_related_synonym: foscarnet
has_related_synonym: phosphonomethanoic acid
imported from: dron.owl

anilide
type: Class
subclass of: benzenes
subclass of: amide
definition: Any amide of aniline.
has_related_synonym: C7H6NOR
id: CHEBI:13248
database_cross_reference: CiteXplore:6205897
database_cross_reference: KEGG COMPOUND:C01402
has_related_synonym: N-phenyl amide
has_related_synonym: N-phenyl amides
has_related_synonym: [*]C(=O)Nc1ccccc1
has_exact_synonym: anilide
imported from: dron.owl

Aspirin
type: Class
label: acetylsalicylic acid
subclass of: benzoic acids
subclass of: acetate ester
has_RxCUI: 1191
has_related_synonym: 2-(ACETYLOXY)BENZOIC ACID
has_exact_synonym: 2-(acetyloxy)benzoic acid
has_related_synonym: 2-Acetoxybenzenecarboxylic acid
has_related_synonym: 2-acetoxybenzoic acid
has_related_synonym: ASA
has_related_synonym: Acetylsalicylate
has_exact_synonym: Acetylsalicylic acid
has_related_synonym: Acetylsalicylsaeure
has_related_synonym: Aspirin
has_related_synonym: Azetylsalizylsaeure
database_cross_reference: Beilstein:779271
definition: Benzoic acid carrying an acetoxy group at the 2-position.
has_related_synonym: C9H8O4
has_related_synonym: CC(=O)Oc1ccccc1C(O)=O
id: CHEBI:15365
has_alternative_id: CHEBI:22188
has_alternative_id: CHEBI:22203
has_alternative_id: CHEBI:2890
has_alternative_id: CHEBI:40705
database_cross_reference: ChemIDplus:50-78-2
database_cross_reference: CiteXplore:11402787
database_cross_reference: CiteXplore:11597554
database_cross_reference: CiteXplore:11733186
database_cross_reference: CiteXplore:12852484
database_cross_reference: CiteXplore:14753751
database_cross_reference: CiteXplore:15542410
database_cross_reference: CiteXplore:15590729
database_cross_reference: CiteXplore:1650428
database_cross_reference: CiteXplore:18226435
database_cross_reference: CiteXplore:18335236
database_cross_reference: CiteXplore:19386367
database_cross_reference: CiteXplore:19706045
database_cross_reference: CiteXplore:21699808
database_cross_reference: CiteXplore:445303
database_cross_reference: DrugBank:DB00945
has_related_synonym: Easprin
database_cross_reference: Gmelin:218864
has_related_synonym: InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
has_related_synonym: InChIKey=BSYNRYMUTXBXSQ-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:50-78-2
database_cross_reference: KEGG COMPOUND:C01405
database_cross_reference: KEGG DRUG:D00109
database_cross_reference: NIST Chemistry WebBook:50-78-2
has_related_synonym: O-acetylsalicylic acid
database_cross_reference: PDBeChem:AIN
database_cross_reference: Reaxys:779271
database_cross_reference: Wikipedia:Aspirin
has_related_synonym: acide 2-(acetyloxy)benzoique
has_related_synonym: acide acetylsalicylique
has_related_synonym: acido acetilsalicilico
has_related_synonym: acidum acetylsalicylicum
has_related_synonym: o-acetoxybenzoic acid
has_related_synonym: o-carboxyphenyl acetate
has_related_synonym: salicylic acid acetate
imported from: dron.owl

L-dopa
type: Class
label: Levodopa
subclass of: dopa
has_related_synonym: (-)-3-(3,4-dihydroxyphenyl)-L-alanine
has_related_synonym: (-)-dopa
has_exact_synonym: (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid
has_related_synonym: 3,4-DIHYDROXYPHENYLALANINE
has_related_synonym: 3,4-Dihydroxy-L-phenylalanine
has_related_synonym: 3-Hydroxy-L-tyrosine
has_RxCUI: 6375
definition: An optically active form of dopa having L-configuration.
database_cross_reference: Beilstein:2215169
database_cross_reference: Beilstein:6060047
has_related_synonym: C9H11NO4
has_alternative_id: CHEBI:11693
has_alternative_id: CHEBI:13098
has_alternative_id: CHEBI:1377
id: CHEBI:15765
has_alternative_id: CHEBI:19825
has_alternative_id: CHEBI:41871
has_alternative_id: CHEBI:49933
database_cross_reference: COMe:MOL000169
database_cross_reference: ChemIDplus:59-92-7
database_cross_reference: CiteXplore:8301021
has_related_synonym: Dihydroxy-L-phenylalanine
has_related_synonym: Dopar
database_cross_reference: DrugBank:DB01235
database_cross_reference: Gmelin:365846
has_related_synonym: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
has_related_synonym: InChIKey=WTDRDQBEARUVNC-LURJTMIESA-N
database_cross_reference: KEGG COMPOUND:59-92-7
database_cross_reference: KEGG COMPOUND:C00355
database_cross_reference: KEGG DRUG:D00059
has_exact_synonym: L-DOPA
has_exact_synonym: L-Dopa
has_related_synonym: L-beta-(3,4-Dihydroxyphenyl)alanine
has_exact_synonym: L-dopa
database_cross_reference: NIST Chemistry WebBook:59-92-7
has_related_synonym: N[C@@H](Cc1ccc(O)c(O)c1)C(O)=O
database_cross_reference: PDBeChem:DAH_LFOH
database_cross_reference: Reaxys:2215169
database_cross_reference: Wikipedia:Levodopa
has_related_synonym: beta-(3,4-dihydroxyphenyl)-L-alanine
has_related_synonym: beta-(3,4-dihydroxyphenyl)alanine
has_related_synonym: levodopa
has_related_synonym: levodopum
imported from: dron.owl

organic sulfide
type: Class
subclass of: sulfide
subclass of: organosulfur compound
has_alternative_id: CHEBI:13694
id: CHEBI:16385
has_alternative_id: CHEBI:26960
has_alternative_id: CHEBI:9340
definition: Compounds having the structure RSR (R =/= H). Such compounds were once called thioethers.
database_cross_reference: KEGG COMPOUND:C00297
has_related_synonym: RSR
has_related_synonym: SR2
has_related_synonym: Sulfide
has_related_synonym: Thioether
has_related_synonym: organic sulfides
has_exact_synonym: sulfides
has_related_synonym: thioether
has_related_synonym: thioethers
imported from: dron.owl

peptide
type: Class
subclass of: carboxamide
subclass of: organic amino compound
definition: Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid.
has_related_synonym: C2H4NO2R(C2H2NOR)n
has_alternative_id: CHEBI:14753
id: CHEBI:16670
has_alternative_id: CHEBI:25906
has_alternative_id: CHEBI:7990
database_cross_reference: KEGG COMPOUND:C00012
has_related_synonym: Peptid
has_exact_synonym: Peptide
has_exact_synonym: peptides
has_related_synonym: peptido
has_related_synonym: peptidos
imported from: dron.owl

Codeine
type: Class
label: codeine
subclass of: morphinane alkaloid
subclass of: organic heteropentacyclic compound
has_related_synonym: (5alpha,6alpha)-7,8-Didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol
has_RxCUI: 2670
has_exact_synonym: 3-methoxy-17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-6alpha-ol
has_related_synonym: 7,8-didehydro-4,5alpha-epoxy-3-methoxy-17-methylmorphinan-6alpha-ol
database_cross_reference: Beilstein:5303198
database_cross_reference: Beilstein:5768734
database_cross_reference: Beilstein:94996
has_related_synonym: C18H21NO3
has_alternative_id: CHEBI:14006
id: CHEBI:16714
has_alternative_id: CHEBI:23348
has_alternative_id: CHEBI:3803
database_cross_reference: ChemIDplus:76-57-3
database_cross_reference: CiteXplore:2215478
has_related_synonym: Codein
has_exact_synonym: Codeine
definition: Codeine is an alkaloid found in the opium poppy, Papaver somniferum var. album; has analgesic, anti-tussive and anti-diarrhoeal properties.
has_related_synonym: Codicept
has_related_synonym: Coducept
database_cross_reference: DrugBank:DB00318
database_cross_reference: Gmelin:232454
has_related_synonym: InChI=1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3-6,11-13,17,20H,7-9H2,1-2H3/t11-,12+,13-,17-,18-/m0/s1
has_related_synonym: InChIKey=OROGSEYTTFOCAN-DNJOTXNNSA-N
database_cross_reference: KEGG COMPOUND:76-57-3
database_cross_reference: KEGG COMPOUND:C06174
database_cross_reference: NIST Chemistry WebBook:76-57-3
has_related_synonym: O(3)-methylmorphine
database_cross_reference: Wikipedia:Codeine
has_related_synonym: codeina
has_related_synonym: codeine
has_related_synonym: codeine anhydrous
has_related_synonym: l-codeine
has_related_synonym: methylmorphine
has_related_synonym: morphine 3-methyl ether
has_related_synonym: morphine monomethyl ether
has_related_synonym: morphine-3-methyl ether
imported from: dron.owl

primary aliphatic amine
type: Class
subclass of: primary amine
has_related_synonym: CH4NR
has_alternative_id: CHEBI:13431
id: CHEBI:17062
has_alternative_id: CHEBI:8749
database_cross_reference: KEGG COMPOUND:C00375
has_related_synonym: NC[*]
has_related_synonym: RCH2NH2
has_related_synonym: primary aliphatic amines
imported from: dron.owl

Streptomycin
type: Class
label: streptomycin
subclass of: streptomycins
has_RxCUI: 10109
has_related_synonym: 2,4-Diguanidino-3,5,6-trihydroxycyclohexyl 5-deoxy-2-O-(2-deoxy-2-methylamino-alpha-L-glucopyranosyl)-3-C-formyl-beta-L-lyxopentanofuranoside
definition: A amino cyclitol glycoside that consists of streptidine having a disaccharyl moiety attached at the 4-position. The parent of the streptomycin class
database_cross_reference: Beilstein:74498
has_related_synonym: C21H39N7O12
has_alternative_id: CHEBI:15119
id: CHEBI:17076
has_alternative_id: CHEBI:26784
has_alternative_id: CHEBI:45745
has_alternative_id: CHEBI:9284
database_cross_reference: ChemIDplus:57-92-1
database_cross_reference: CiteXplore:11228320
database_cross_reference: CiteXplore:11905029
database_cross_reference: CiteXplore:12118520
database_cross_reference: CiteXplore:13030054
database_cross_reference: CiteXplore:13116094
database_cross_reference: CiteXplore:13136149
database_cross_reference: CiteXplore:13596285
database_cross_reference: CiteXplore:13691614
database_cross_reference: CiteXplore:13985260
database_cross_reference: CiteXplore:13990247
database_cross_reference: CiteXplore:14623118
database_cross_reference: CiteXplore:14828344
database_cross_reference: CiteXplore:14852338
database_cross_reference: CiteXplore:14939639
database_cross_reference: CiteXplore:15081082
database_cross_reference: CiteXplore:15137533
database_cross_reference: CiteXplore:15207172
database_cross_reference: CiteXplore:15686853
database_cross_reference: CiteXplore:15736038
database_cross_reference: CiteXplore:16904706
database_cross_reference: CiteXplore:17105735
database_cross_reference: CiteXplore:17238915
database_cross_reference: CiteXplore:17429930
database_cross_reference: CiteXplore:18173084
database_cross_reference: CiteXplore:18916143
database_cross_reference: CiteXplore:19052412
database_cross_reference: CiteXplore:19335957
database_cross_reference: CiteXplore:21350946
database_cross_reference: CiteXplore:21362244
database_cross_reference: CiteXplore:21593257
database_cross_reference: CiteXplore:21937264
database_cross_reference: DrugBank:DB01082
has_related_synonym: InChI=1S/C21H39N7O12/c1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35/h4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28)/t5-,6-,7+,8-,9-,10-,11+,12-,13-,14+,15+,16-,17-,18-,21+/m0/s1
has_related_synonym: InChIKey=UCSJYZPVAKXKNQ-HZYVHMACSA-N
database_cross_reference: KEGG COMPOUND:57-92-1
database_cross_reference: KEGG COMPOUND:C00413
database_cross_reference: KEGG DRUG:D08531
has_related_synonym: Kantrex
has_exact_synonym: N,N'''-[(1R,2R,3S,4R,5R,6S)-4-{5-deoxy-2-O-[2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl]-3-C-formyl-alpha-L-lyxofuranosyloxy}-2,5,6-trihydroxycyclohexane-1,3-diyl]diguanidine
database_cross_reference: PDBeChem:SRY
database_cross_reference: Reaxys:74498
has_related_synonym: SM
has_exact_synonym: STREPTOMYCIN
database_cross_reference: Wikipedia:Streptomycin
has_related_synonym: [2-deoxy-2-(dimethylamino)-alpha-L-glucopyranosyl]-(1->2)-[5-deoxy-3-C-formyl-alpha-L-lyxofuranosyl]-(1->4)-{N',N'''-[(1,3,5/2,4,6)-2,4,5,6-tetrahydroxycyclohexane-1,3-diyl]diguanidine}
has_related_synonym: streptomycin
imported from: dron.owl

ketone
type: Class
subclass of: carbonyl compound
definition: A compound in which a carbonyl group is bonded to two carbon atoms: R2C=O (neither R may be H).
has_alternative_id: CHEBI:13427
id: CHEBI:17087
has_alternative_id: CHEBI:24974
has_alternative_id: CHEBI:6127
has_alternative_id: CHEBI:8742
has_related_synonym: COR2
database_cross_reference: KEGG COMPOUND:C00709
database_cross_reference: KEGG COMPOUND:C01450
has_related_synonym: Keton
has_exact_synonym: Ketone
has_related_synonym: R-CO-R'
has_related_synonym: [*]C([*])=O
has_related_synonym: cetone
has_related_synonym: ketones
has_exact_synonym: ketones
imported from: dron.owl

penicillin
type: Class
subclass of: penicillanic acids
definition: Any member of the group of substituted penams containing two methyl substituents at position 2, a carboxylate substituent at position 3 and a carboxamido group at position 6.
has_related_synonym: C9H11N2O4SR
has_alternative_id: CHEBI:14742
id: CHEBI:17334
has_alternative_id: CHEBI:25869
has_alternative_id: CHEBI:7961
database_cross_reference: CiteXplore:12833570
database_cross_reference: CiteXplore:1502708
database_cross_reference: CiteXplore:16033609
database_cross_reference: CiteXplore:7798534
database_cross_reference: KEGG COMPOUND:C00395
has_exact_synonym: Penicillin
has_exact_synonym: penicillin
has_exact_synonym: penicillins
has_related_synonym: penicillins
imported from: dron.owl

gemcitabine
type: Class
subclass of: pyrimidine 2'-deoxyribonucleoside
subclass of: organofluorine compound
has_RxCUI: 12574
has_related_synonym: 2',2'-Difluorodeoxycytidine
has_related_synonym: 2'-Deoxy-2',2'-difluorocytidine
has_exact_synonym: 2'-deoxy-2',2'-difluorocytidine
has_related_synonym: 4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
definition: A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. Gemcitabine is used in various carcinomas: non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.
database_cross_reference: Beilstein:5382060
has_related_synonym: C9H11F2N3O4
id: CHEBI:175901
has_alternative_id: CHEBI:42752
has_alternative_id: CHEBI:5295
database_cross_reference: ChEMBL:11356111
database_cross_reference: ChEMBL:17101674
database_cross_reference: ChEMBL:175901
database_cross_reference: ChEMBL:17602464
database_cross_reference: ChEMBL:17887663
database_cross_reference: ChEMBL:17939651
database_cross_reference: ChEMBL:18186604
database_cross_reference: ChEMBL:18257544
database_cross_reference: ChemIDplus:95058-81-4
database_cross_reference: CiteXplore:11034044
database_cross_reference: CiteXplore:11061612
database_cross_reference: CiteXplore:11088063
database_cross_reference: CiteXplore:11122828
database_cross_reference: CiteXplore:11132538
database_cross_reference: CiteXplore:11142482
database_cross_reference: CiteXplore:11221019
database_cross_reference: CiteXplore:11374818
database_cross_reference: CiteXplore:11489002
database_cross_reference: CiteXplore:11504793
database_cross_reference: CiteXplore:11510027
database_cross_reference: CiteXplore:11585734
database_cross_reference: CiteXplore:11595724
database_cross_reference: CiteXplore:11807603
database_cross_reference: CiteXplore:11859947
database_cross_reference: CiteXplore:11901308
database_cross_reference: CiteXplore:12057041
database_cross_reference: CiteXplore:12057046
database_cross_reference: CiteXplore:12057157
database_cross_reference: CiteXplore:12115355
database_cross_reference: CiteXplore:12142097
database_cross_reference: CiteXplore:12571808
database_cross_reference: CiteXplore:12722678
database_cross_reference: CiteXplore:12722691
database_cross_reference: CiteXplore:12743987
database_cross_reference: CiteXplore:12761494
database_cross_reference: CiteXplore:12798170
database_cross_reference: CiteXplore:12917815
database_cross_reference: CiteXplore:12954073
database_cross_reference: CiteXplore:14606642
database_cross_reference: CiteXplore:14653877
database_cross_reference: CiteXplore:14720338
database_cross_reference: CiteXplore:15131028
database_cross_reference: CiteXplore:15160243
database_cross_reference: CiteXplore:15221904
database_cross_reference: CiteXplore:15282439
database_cross_reference: CiteXplore:15297392
database_cross_reference: CiteXplore:15542781
database_cross_reference: CiteXplore:15637766
database_cross_reference: CiteXplore:15744590
database_cross_reference: CiteXplore:16001951
database_cross_reference: CiteXplore:16041610
database_cross_reference: CiteXplore:16080557
database_cross_reference: CiteXplore:16143373
database_cross_reference: CiteXplore:16149285
database_cross_reference: CiteXplore:16317298
database_cross_reference: CiteXplore:16500746
database_cross_reference: CiteXplore:16555971
database_cross_reference: CiteXplore:16584929
database_cross_reference: CiteXplore:16807461
database_cross_reference: CiteXplore:16807463
database_cross_reference: CiteXplore:16894289
database_cross_reference: CiteXplore:16905983
database_cross_reference: CiteXplore:17296311
database_cross_reference: CiteXplore:17296587
database_cross_reference: CiteXplore:17347561

Hydrocortisone
type: Class
label: cortisol
subclass of: glucocorticoid
subclass of: 17alpha-hydroxy steroid
subclass of: 21-hydroxy steroid
subclass of: 11beta-hydroxy steroid
subclass of: 20-oxo steroid
subclass of: 3-oxo steroid
subclass of: C21-steroid
has_related_synonym: (11beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
has_exact_synonym: 11beta,17,21-trihydroxypregn-4-ene-3,20-dione
has_related_synonym: 11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
has_related_synonym: 11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione
has_related_synonym: 11beta-hydrocortisone
has_related_synonym: 17-hydroxycorticosterone
has_related_synonym: 4-pregnen-11beta,17alpha,21-triol-3,20-dione
has_RxCUI: 5492
database_cross_reference: Beilstein:1354819
has_related_synonym: C21H30O5
has_alternative_id: CHEBI:14023
id: CHEBI:17650
has_alternative_id: CHEBI:24633
has_alternative_id: CHEBI:3893
has_alternative_id: CHEBI:58221
database_cross_reference: ChemIDplus:50-23-7
database_cross_reference: CiteXplore:10438974
has_exact_synonym: Cortisol
definition: Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the "stress hormone" as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immune responses
database_cross_reference: DrugBank:DB00741
has_related_synonym: Hydrocortisone
has_related_synonym: InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
has_related_synonym: InChIKey=JYGXADMDTFJGBT-VWUMJDOOSA-N
database_cross_reference: KEGG COMPOUND:50-23-7
database_cross_reference: KEGG COMPOUND:C00735
database_cross_reference: KEGG DRUG:D00088
has_related_synonym: Kendall's compound F
database_cross_reference: LIPID MAPS:LMST02030001
database_cross_reference: NIST Chemistry WebBook:50-23-7
database_cross_reference: Patent:US2602769
has_related_synonym: Reichstein's substance M
database_cross_reference: Wikipedia:Hydrocortisone
has_exact_synonym: cortisol
has_related_synonym: hidrocortisona
has_related_synonym: hydrocortisone
has_related_synonym: hydrocortisonum
imported from: dron.owl

Gentamicin Sulfate (USP)
type: Class
label: gentamycin
subclass of: amino cyclitol glycoside
subclass of: aminoglycoside antibiotic
has_RxCUI: 142438
has_exact_synonym: 4,6-diamino-3-[3-deoxy-4-C-methyl-3-(methylamino)pentopyranosyloxy]-2-hydroxycyclohexyl 2-amino-2,3,4,6,7-pentadeoxy-6-(methylamino)heptopyranoside
definition: Any of a group of aminoglycoside antibiotics produced by fermentation of some Micromonospora spp.
has_alternative_id: CHEBI:14293
id: CHEBI:17833
has_alternative_id: CHEBI:24206
has_alternative_id: CHEBI:24212
has_alternative_id: CHEBI:5306
has_related_synonym: Gentamicin
database_cross_reference: KEGG COMPOUND:1403-66-3
database_cross_reference: KEGG COMPOUND:C00505
has_related_synonym: gentamicin
has_related_synonym: gentamycins
imported from: dron.owl

lipid
type: Class
subclass of: organic molecular entity
definition: 'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids.
has_alternative_id: CHEBI:14517
id: CHEBI:18059
has_alternative_id: CHEBI:25054
has_alternative_id: CHEBI:6486
database_cross_reference: KEGG COMPOUND:C01356
has_exact_synonym: Lipid
has_exact_synonym: lipid
has_exact_synonym: lipids
imported from: dron.owl

Penicillin G
type: Class
label: benzylpenicillin
subclass of: penicillin
has_related_synonym: (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
has_exact_synonym: 2,2-dimethyl-6beta-(phenylacetamido)penam-3alpha-carboxylic acid
has_related_synonym: 6-(2-phenylacetamido)penicillanic acid
has_RxCUI: 7980
definition: A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group.
database_cross_reference: Beilstein:44740
has_exact_synonym: Benzylpenicillin
has_related_synonym: C16H18N2O4S
has_alternative_id: CHEBI:14743
id: CHEBI:18208
has_alternative_id: CHEBI:25866
has_alternative_id: CHEBI:45073
has_alternative_id: CHEBI:7962
database_cross_reference: ChemIDplus:61-33-6
database_cross_reference: CiteXplore:10930630
database_cross_reference: CiteXplore:11431418
database_cross_reference: CiteXplore:11906332
database_cross_reference: CiteXplore:12569987
database_cross_reference: CiteXplore:12850488
database_cross_reference: CiteXplore:1384868
database_cross_reference: CiteXplore:16033609
database_cross_reference: CiteXplore:1709917
database_cross_reference: CiteXplore:2083978
database_cross_reference: CiteXplore:6161899
database_cross_reference: CiteXplore:7602118
database_cross_reference: CiteXplore:7716788
database_cross_reference: DrugBank:DB01053
database_cross_reference: Gmelin:781913
has_related_synonym: InChI=1S/C16H18N2O4S/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/t11-,12+,14-/m1/s1
has_related_synonym: InChIKey=JGSARLDLIJGVTE-MBNYWOFBSA-N
database_cross_reference: KEGG COMPOUND:61-33-6
database_cross_reference: KEGG COMPOUND:C05551
database_cross_reference: KEGG DRUG:D02336
database_cross_reference: PDBeChem:PNN
has_related_synonym: PENICILLIN G
has_related_synonym: PG
database_cross_reference: Patent:US3024169
has_related_synonym: Penicillin G
database_cross_reference: Reaxys:44740
database_cross_reference: Wikipedia:Penicillin_G
has_related_synonym: bencilpenicilina
has_related_synonym: benzylpenicillin
has_related_synonym: benzylpenicilline
has_related_synonym: benzylpenicillinic acid
has_related_synonym: benzylpenicillinum
has_related_synonym: free penicillin II
imported from: dron.owl

2'-deoxyribonucleoside
type: Class
subclass of: deoxyribonucleoside
subclass of: monohydroxytetrahydrofuran
has_related_synonym: 2'-Deoxynucleoside
has_related_synonym: 2'-deoxynucleoside
has_related_synonym: 2'-deoxyribonucleosides
has_related_synonym: 2-Deoxy-D-ribosyl-base
has_alternative_id: CHEBI:1083
has_alternative_id: CHEBI:11394
has_alternative_id: CHEBI:11567
has_alternative_id: CHEBI:11568
id: CHEBI:18274
has_alternative_id: CHEBI:19259
has_alternative_id: CHEBI:19560
has_alternative_id: CHEBI:4421
has_related_synonym: Deoxynucleoside
database_cross_reference: KEGG COMPOUND:C02269
database_cross_reference: KEGG COMPOUND:C03216
imported from: dron.owl

nitrile
type: Class
subclass of: cyanides
definition: A compound having the structure RC#N; thus a C-substituted derivative of hydrocyanic acid, HC#N. In systematic nomenclature, the suffix nitrile denotes the triply bound #N atom, not the carbon atom attached to it.
has_alternative_id: CHEBI:13212
has_alternative_id: CHEBI:13426
has_alternative_id: CHEBI:13660
id: CHEBI:18379
has_alternative_id: CHEBI:25547
has_alternative_id: CHEBI:7584
has_related_synonym: CNR
database_cross_reference: KEGG COMPOUND:C00726
has_related_synonym: Nitril
has_exact_synonym: Nitrile
has_related_synonym: R-CN
has_related_synonym: [*]C#N
has_exact_synonym: nitrile
has_exact_synonym: nitriles
has_related_synonym: nitrilos
imported from: dron.owl

delta-lactone
type: Class
subclass of: lactone
has_related_synonym: 1,5-lactone
has_related_synonym: 1,5-lactones
id: CHEBI:18946
has_related_synonym: delta-lactona
has_related_synonym: delta-lactonas
has_exact_synonym: delta-lactone
has_related_synonym: delta-lactones
imported from: dron.owl

17-oxo steroid
type: Class
subclass of: oxo steroid
has_related_synonym: 17-keto steroids
has_related_synonym: 17-ketosteroids
has_related_synonym: 17-oxo steroids
id: CHEBI:19168
imported from: dron.owl

purine 2'-deoxyribonucleoside
type: Class
subclass of: 2'-deoxyribonucleoside
subclass of: purine deoxyribonucleoside
id: CHEBI:19254
has_related_synonym: purine 2'-deoxyribonucleosides
imported from: dron.owl

pyrimidine 2'-deoxyribonucleoside
type: Class
subclass of: 2'-deoxyribonucleoside
subclass of: pyrimidine nucleoside
id: CHEBI:19255
has_related_synonym: pyrimidine 2'-deoxyribonucleosides
imported from: dron.owl

2-aminopurines
type: Class
subclass of: aminopurine
has_exact_synonym: 2-aminopurines
definition: Any aminopurine having the amino substituent at the 2-position.
id: CHEBI:20702
imported from: dron.owl

N-glycosyl compound
type: Class
subclass of: organonitrogen compound
subclass of: glycosyl compound
definition: A glycosyl compound arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to a nitrogen atom, thus creating a C-N bond.
id: CHEBI:21731
has_related_synonym: N-glycoside
has_related_synonym: N-glycosides
has_related_synonym: N-glycosyl compounds
has_exact_synonym: glycosylamine
has_related_synonym: glycosylamines
imported from: dron.owl

alkaloid
type: Class
subclass of: organonitrogen compound
has_exact_synonym: Alkaloid
has_related_synonym: Alkaloide
definition: Any of basic nitrogen compounds (mostly heterocyclic) occurring mostly in the plant kingdom (but not excluding those of animal origin). Amino acids, peptides, proteins, nucleotides, nucleic acids, amino sugars and antibiotics are not normally regarded as alkaloids. By extension, certain neutral compounds biogenetically related to basic alkaloids are included.
id: CHEBI:22315
has_related_synonym: alcaloide
has_related_synonym: alcaloides
has_exact_synonym: alkaloids
imported from: dron.owl

alkyl sulfide
type: Class
subclass of: organic sulfide
id: CHEBI:22327
imported from: dron.owl

amino alcohol
type: Class
subclass of: alcohol
subclass of: organic amino compound
definition: An alcohol containing an amino functional group in addition to the alcohol-defining hydroxy group.
id: CHEBI:22478
has_related_synonym: amino alcohols
has_related_synonym: aminoalcohol
has_related_synonym: aminoalcohols
imported from: dron.owl

amino cyclitol glycoside
type: Class
subclass of: cyclitol
subclass of: glycoside
id: CHEBI:22479
has_exact_synonym: amino cyclitol glycoside
has_related_synonym: amino cyclitol glycosides
imported from: dron.owl

aminoglycoside antibiotic
type: Class
subclass of: carbohydrate-containing antibiotic
subclass of: aminoglycoside
id: CHEBI:22507
has_related_synonym: aminoglycoside antibiotics
imported from: dron.owl

aminopurine
type: Class
subclass of: purines
definition: Any purine having at least one amino substituent.
id: CHEBI:22527
has_related_synonym: aminopurines
imported from: dron.owl

anthraquinone
type: Class
subclass of: anthracenes
subclass of: acenoquinone
id: CHEBI:22580
has_related_synonym: anthracenequinones
has_related_synonym: anthraquinones
imported from: dron.owl

azides
type: Class
subclass of: nitrogen molecular entity
id: CHEBI:22680
definition: Compounds containing the group -N3, and salts of hydrazoic acid, HN3.
has_exact_synonym: azides
imported from: dron.owl

azobenzenes
type: Class
subclass of: benzenes
subclass of: azo compound
definition: Any member of the wide class of molecules that share the core azobenzene structure, comprising two phenyl rings linked by a N=N double bond, which may have different functional groups extending from the rings.
id: CHEBI:22682
has_exact_synonym: azobenzenes
imported from: dron.owl

barbiturates
type: Class
subclass of: cyclic pseudoketone
subclass of: pyrimidone
id: CHEBI:22693
definition: Pyrimidine-2,4,6(1H,3H,5H)-trione (barbituric acid) and derivatives. Largest group of the synthetic sedative/hypnotics, sharing a characteristic six-membered ring structure.
has_exact_synonym: barbiturates
has_related_synonym: barbituric acids
imported from: dron.owl

benzenes
type: Class
subclass of: benzenoid aromatic compound
id: CHEBI:22712
imported from: dron.owl

benzimidazoles
type: Class
subclass of: organic heterobicyclic compound
subclass of: organonitrogen heterocyclic compound
definition: An organic heterocyclic compound containing a benzene ring fused to an imidazole ring.
id: CHEBI:22715
imported from: dron.owl

benzoic acids
type: Class
subclass of: benzenes
subclass of: monocarboxylic acid
id: CHEBI:22723
imported from: dron.owl

benzopyrrole
type: Class
subclass of: organic heterobicyclic compound
subclass of: organonitrogen heterocyclic compound
subclass of: polycyclic heteroarene
id: CHEBI:22728
has_related_synonym: benzopyrroles
imported from: dron.owl

beta-D-glucoside
type: Class
subclass of: D-glucoside
subclass of: beta-glucoside
id: CHEBI:22798
has_exact_synonym: beta-D-glucoside
has_related_synonym: beta-D-glucosides
imported from: dron.owl

biphenyls
type: Class
subclass of: benzenoid aromatic compound
subclass of: biaryl
definition: Benzenoid aromatic compounds containing two phenyl or substituted-phenyl groups which are joined together by a single bond.
id: CHEBI:22888
imported from: dron.owl

carbamate ester
type: Class
subclass of: carboxylic ester
definition: An ester of carbamic acid.
id: CHEBI:23003
has_related_synonym: carbamate esters
has_related_synonym: carbamates
imported from: dron.owl

carbohydrate-containing antibiotic
type: Class
subclass of: carbohydrate derivative
id: CHEBI:23007
imported from: dron.owl

cephalosporin
type: Class
subclass of: cephem
definition: A class of beta-lactam antibiotics differing from the penicillins in having a 6-membered, rather than a 5-membered, side ring.
has_related_synonym: C7H5NO3SR2
id: CHEBI:23066
has_alternative_id: CHEBI:3538
has_exact_synonym: Cephalosporin
database_cross_reference: CiteXplore:12833570
database_cross_reference: CiteXplore:6762896
database_cross_reference: KEGG COMPOUND:C00875
has_related_synonym: cephalosporins
imported from: dron.owl

chlorine molecular entity
type: Class
subclass of: halogen molecular entity
id: CHEBI:23117
imported from: dron.owl

Colchicine
type: Class
label: colchicine
subclass of: carbotricyclic compound
has_RxCUI: 2683
definition: A carbotricyclic compound comprising 5,6,7,9-tetrahydrobenzo[a]heptalene having four methoxy substituents at the 1-, 2-, 3- and 10-positions as well as an oxo group at the 9-position and an acetamido group at the 7-position.
database_cross_reference: Beilstein:2228812
has_related_synonym: C22H25NO6
id: CHEBI:23359
has_related_synonym: COc1cc2CCC(NC(C)=O)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC
database_cross_reference: CiteXplore:9819133
has_related_synonym: InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)
has_related_synonym: InChIKey=IAKHMKGGTNLKSZ-UHFFFAOYSA-N
has_exact_synonym: N-(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide
database_cross_reference: NIST Chemistry WebBook:54192-66-4
database_cross_reference: Reaxys:2228812
imported from: dron.owl

molecular entity
type: Class
subclass of: object
definition: Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity.
id: CHEBI:23367
has_related_synonym: entidad molecular
has_related_synonym: entidades moleculares
has_related_synonym: entite moleculaire
has_related_synonym: molecular entities
has_exact_synonym: molecular entity
has_related_synonym: molekulare Entitaet
imported from: dron.owl

cyanides
type: Class
subclass of: organonitrogen compound
id: CHEBI:23424
definition: Salts and C-organyl derivatives of hydrogen cyanide, HC#N.
has_exact_synonym: cyanides
imported from: dron.owl

cyclic amide
type: Class
subclass of: amide
id: CHEBI:23443
has_exact_synonym: cyclic amide
has_related_synonym: cyclic amides
imported from: dron.owl

cyclic peptide
type: Class
subclass of: peptide
id: CHEBI:23449
has_related_synonym: Cyclopeptid
has_related_synonym: Zyklopeptid
has_related_synonym: cyclic peptides
has_related_synonym: peptide cyclique
has_related_synonym: peptido ciclico
imported from: dron.owl

cyclitol
type: Class
subclass of: polyol
definition: A polyol consisting of a cycloalkane containing at least three hydroxy groups, each attached to a different ring carbon atom.
id: CHEBI:23451
has_exact_synonym: cyclitols
imported from: dron.owl

cyclohexanols
type: Class
subclass of: alcohol
id: CHEBI:23480
imported from: dron.owl

deoxyribonucleoside
type: Class
subclass of: nucleoside
id: CHEBI:23636
has_related_synonym: deoxyribonucleosides
imported from: dron.owl

diamine
type: Class
subclass of: organic amino compound
id: CHEBI:23666
has_exact_synonym: diamines
imported from: dron.owl

diazole
type: Class
subclass of: organic heteromonocyclic compound
subclass of: organonitrogen heterocyclic compound
id: CHEBI:23677
definition: Either one of a pair of heterocyclic organic compounds comprising three carbon atoms and two nitrogen atoms arranged in a ring.
has_related_synonym: diazoles
imported from: dron.owl

quinolone
type: Class
subclass of: quinolines
id: CHEBI:23765
has_related_synonym: quinolones
imported from: dron.owl

diterpenoid
type: Class
subclass of: terpenoid
definition: Any terpenoid having a C20 skeleton, derived from geranylgeranyl phosphate.
has_related_synonym: C20 isoprenoids
id: CHEBI:23849
database_cross_reference: LIPID MAPS:LMPR0104
has_related_synonym: diterpenoides
has_exact_synonym: diterpenoids
imported from: dron.owl

ethanolamines
type: Class
subclass of: amino alcohol
id: CHEBI:23981
has_related_synonym: ethanolamine
imported from: dron.owl

fluorine molecular entity
type: Class
subclass of: halogen molecular entity
id: CHEBI:24062
has_related_synonym: fluorine compounds
has_related_synonym: fluorine molecular entities
has_exact_synonym: fluorine molecular entity
imported from: dron.owl

furans
type: Class
subclass of: organic heteromonocyclic compound
subclass of: oxacycle
id: CHEBI:24129
definition: Compounds containing at least one furan ring.
has_related_synonym: oxacyclopenta-2,4-dienes
imported from: dron.owl

glucocorticoid
type: Class
subclass of: corticosteroid hormone
id: CHEBI:24261
definition: Glucocorticoids are a class of steroid hormones that regulate a variety of physiological processes, in particular control of the concentration of glucose in blood.
has_related_synonym: glucocorticoids
imported from: dron.owl

glucoside
type: Class
subclass of: hexoside
id: CHEBI:24278
has_related_synonym: glucosides
imported from: dron.owl

glycoside
type: Class
subclass of: glycosyl compound
definition: A glycosyl compound resulting from the attachment of a glycosyl group to a non-acyl group RO-, which itself may be derived from a saccharide and chalcogen replacements thereof (RS-, RSe-). The bond between the glycosyl group and the OR group is called a glycosidic bond. By extension, the terms N-glycosides and C-glycosides are used as class names for glycosylamines and for compounds having a glycosyl group attached to a hydrocarbyl group respectively. These terms are misnomers and should not be used. The preferred terms are glycosylamines and C-glycosyl compounds, respectively.
id: CHEBI:24400
has_related_synonym: O-glycoside
has_related_synonym: O-glycosides
has_related_synonym: glycosides
has_exact_synonym: glycosides
imported from: dron.owl

chemical entity
type: Class
subclass of: object
definition: A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances.
id: CHEBI:24431
imported from: dron.owl

guanidines
type: Class
subclass of: amine
id: CHEBI:24436
imported from: dron.owl

halogen molecular entity
type: Class
subclass of: p-block molecular entity
id: CHEBI:24471
has_related_synonym: halogen compounds
has_related_synonym: halogen molecular entities
has_exact_synonym: halogen molecular entity
imported from: dron.owl

heterocyclic antibiotic
type: Class
subclass of: organic heterocyclic compound
id: CHEBI:24531
imported from: dron.owl

organic heterocyclic compound
type: Class
subclass of: heteroorganic entity
subclass of: organic cyclic compound
subclass of: heterocyclic compound
definition: A cyclic compound having as ring members atoms of carbon and at least of one other element.
id: CHEBI:24532
has_related_synonym: organic heterocycle
has_related_synonym: organic heterocyclic compounds
imported from: dron.owl

homodetic cyclic peptide
type: Class
subclass of: cyclic peptide
definition: A homodetic cyclic peptide is a cyclic peptide in which the ring consists solely of amino-acid residues in peptide linkages.
id: CHEBI:24613
has_exact_synonym: homodetic cyclic peptide
has_related_synonym: homodetic cyclic peptides
has_related_synonym: peptide cyclique homodetique
has_related_synonym: peptido ciclico homodetico
imported from: dron.owl

imidazolidine-2,4-dione
type: Class
subclass of: imidazolidinone
id: CHEBI:24628
imported from: dron.owl

hydroxides
type: Class
subclass of: oxygen molecular entity
subclass of: hydrogen molecular entity
subclass of: heteroatomic molecular entity
id: CHEBI:24651
definition: Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-)).
imported from: dron.owl

hydroxy-amino acid
type: Class
subclass of: modified amino acid
id: CHEBI:24662
imported from: dron.owl

hydroxy carboxylic acid
type: Class
subclass of: carboxylic acid
id: CHEBI:24669
has_related_synonym: hydroxy carboxylic acids
imported from: dron.owl

hydroxyphenylalanine
type: Class
subclass of: hydroxy-amino acid
subclass of: phenylalanine derivative
id: CHEBI:24734
imported from: dron.owl

imidazoles
type: Class
subclass of: diazole
definition: A five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton.
id: CHEBI:24780
imported from: dron.owl

indole-3-acetic acids
type: Class
subclass of: indol-3-yl carboxylic acid
id: CHEBI:24803
imported from: dron.owl

indol-3-yl carboxylic acid
type: Class
subclass of: indolyl carboxylic acid
id: CHEBI:24810
has_related_synonym: indol-3-yl carboxylic acids
imported from: dron.owl

indoles
type: Class
subclass of: benzopyrrole
definition: Any compound containing an indole skeleton.
id: CHEBI:24828
imported from: dron.owl

indolones
type: Class
subclass of: indoles
id: CHEBI:24829
imported from: dron.owl

oxoacid
type: Class
subclass of: hydroxides
definition: A compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
id: CHEBI:24833
has_related_synonym: oxacids
has_related_synonym: oxiacids
has_related_synonym: oxo acid
has_exact_synonym: oxoacid
has_exact_synonym: oxoacids
has_related_synonym: oxy-acids
has_related_synonym: oxyacids
imported from: dron.owl

iodine molecular entity
type: Class
subclass of: halogen molecular entity
id: CHEBI:24860
has_related_synonym: iodine compounds
has_related_synonym: iodine molecular entities
has_exact_synonym: iodine molecular entity
imported from: dron.owl

isoprenoid
type: Class
subclass of: lipid
subclass of: organic molecular entity
definition: Any lipid formally derived from isoprene (2-methylbuta-1,3-diene), the skeleton of which can generally be discerned in repeated occurrence in the molecule. The skeleton of isoprenoids may differ from strict additivity of isoprene units by loss or shift of a fragment, commonly a methyl group. The class includes both hydrocarbons and oxygenated derivatives.
id: CHEBI:24913
database_cross_reference: CiteXplore:12769708
database_cross_reference: CiteXplore:19219049
database_cross_reference: LIPID MAPS:LMPR01
has_exact_synonym: isoprenoid
has_related_synonym: isoprenoids
has_exact_synonym: isoprenoids
imported from: dron.owl

isoquinoline alkaloid
type: Class
subclass of: alkaloid
subclass of: isoquinolines
id: CHEBI:24921
has_related_synonym: isoquinoline alkaloids
imported from: dron.owl

isoquinolines
type: Class
subclass of: organic heterobicyclic compound
subclass of: organic aromatic compound
subclass of: organonitrogen heterocyclic compound
definition: A benzopyridine with the nitrogen of the pyridine moiety in position 2.
id: CHEBI:24922
imported from: dron.owl

lactam
type: Class
subclass of: cyclic amide
subclass of: cyclic pseudoketone
subclass of: organonitrogen heterocyclic compound
id: CHEBI:24995
definition: Cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.
has_related_synonym: Laktam
has_related_synonym: Laktame
has_exact_synonym: lactam
has_exact_synonym: lactams
has_related_synonym: lactams
imported from: dron.owl

lactone
type: Class
subclass of: carboxylic ester
subclass of: ester
subclass of: oxacycle
definition: Any cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.
id: CHEBI:25000
has_related_synonym: Lacton
has_related_synonym: Lakton
has_related_synonym: Laktone
has_related_synonym: lactona
has_related_synonym: lactonas
has_exact_synonym: lactone
has_exact_synonym: lactones
imported from: dron.owl

methylxanthine
type: Class
subclass of: purine alkaloid
id: CHEBI:25348
has_related_synonym: methylxanthines
imported from: dron.owl

modified amino acid
type: Class
subclass of: amino acid
id: CHEBI:25359
imported from: dron.owl

monocarboxylic acid
type: Class
subclass of: carboxylic acid
definition: An oxoacid containing a single carboxy group.
id: CHEBI:25384
has_exact_synonym: monocarboxylic acid
has_related_synonym: monocarboxylic acids
imported from: dron.owl

morphinane alkaloid
type: Class
subclass of: isoquinoline alkaloid
id: CHEBI:25418
imported from: dron.owl

organonitrogen heterocyclic antibiotic
type: Class
subclass of: heterocyclic antibiotic
subclass of: organonitrogen heterocyclic compound
id: CHEBI:25558
has_related_synonym: organonitrogen heterocyclic antibiotics
imported from: dron.owl

oligopeptide
type: Class
subclass of: peptide
definition: Any molecule that contains a small number (usually 2 to 10) amino-acid residues connected by peptide linkages.
id: CHEBI:25676
has_related_synonym: Oligopeptid
has_exact_synonym: oligopeptides
has_related_synonym: oligopeptido
imported from: dron.owl

organic heteromonocyclic compound
type: Class
subclass of: organic heterocyclic compound
subclass of: heteromonocyclic compound
id: CHEBI:25693
has_related_synonym: organic heteromonocyclic compounds
imported from: dron.owl

ether
type: Class
subclass of: organic molecular entity
definition: A compound ROR (where R is not H).
id: CHEBI:25698
has_related_synonym: OR2
has_related_synonym: [*]O[*]
has_exact_synonym: ether
has_related_synonym: ethers
has_exact_synonym: ethers
imported from: dron.owl

oxo carboxylic acid
type: Class
subclass of: carboxylic acid
definition: Any compound that has an aldehydic or ketonic group as well as a carboxylic acid group in the same molecule.
id: CHEBI:25754
has_related_synonym: oxo acids
has_related_synonym: oxo carboxylic acids
has_exact_synonym: oxo carboxylic acids
imported from: dron.owl

oxygen molecular entity
type: Class
subclass of: chalcogen molecular entity
id: CHEBI:25806
has_related_synonym: oxygen molecular entities
has_exact_synonym: oxygen molecular entity
imported from: dron.owl

oxopurine
type: Class
subclass of: purines
id: CHEBI:25810
has_related_synonym: oxopurines
imported from: dron.owl

penicillanic acids
type: Class
subclass of: carboxylic acid
subclass of: penams
id: CHEBI:25865
imported from: dron.owl

phenylalanine derivative
type: Class
subclass of: modified amino acid
id: CHEBI:25985
imported from: dron.owl

phosphonic acids
type: Class
subclass of: phosphorus oxoacids and derivatives
id: CHEBI:26069
definition: HP(=O)(OH)2 (phosphonic acid) and its P-substituted derivatives.
has_exact_synonym: phosphonic acids
imported from: dron.owl

phosphorus molecular entity
type: Class
subclass of: pnictogen molecular entity
id: CHEBI:26082
has_related_synonym: phosphorus molecular entities
imported from: dron.owl

piperazines
type: Class
subclass of: organic heteromonocyclic compound
subclass of: organonitrogen heterocyclic compound
id: CHEBI:26144
imported from: dron.owl

piperidines
type: Class
subclass of: organic heteromonocyclic compound
subclass of: organonitrogen heterocyclic compound
id: CHEBI:26151
imported from: dron.owl

Amantadine
type: Class
label: amantadine
subclass of: primary aliphatic amine
subclass of: adamantanes
has_related_synonym: 1-adamantanamine
has_related_synonym: 1-adamantylamine
has_related_synonym: 1-aminoadamantane
has_RxCUI: 620
has_exact_synonym: Amantadine
has_related_synonym: Amantidine
has_related_synonym: Aminoadamantane
definition: An adamantane that has formula C10H17N.
database_cross_reference: Beilstein:2204333
has_related_synonym: C10H17N
id: CHEBI:2618
database_cross_reference: ChemIDplus:768-94-5
database_cross_reference: DrugBank:DB00915
database_cross_reference: Gmelin:27066
has_related_synonym: InChI=1S/C10H17N/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H,1-6,11H2
has_related_synonym: InChIKey=DKNWSYNQZKUICI-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:768-94-5
database_cross_reference: KEGG COMPOUND:C06818
database_cross_reference: KEGG DRUG:D07441
has_related_synonym: NC12CC3CC(CC(C3)C1)C2
database_cross_reference: NIST Chemistry WebBook:768-94-5
has_related_synonym: Viregyt
has_related_synonym: Virosol
database_cross_reference: Wikipedia:Amantadine
has_exact_synonym: adamantan-1-ylamine
has_related_synonym: amantadina
has_related_synonym: amantadine
has_related_synonym: amantadinum
has_related_synonym: tricyclo[3.3.1.1(3,7)]decan-1-amine
has_related_synonym: tricyclo[3.3.1.1(3,7)]decan-1-ylamine
has_related_synonym: tricyclo[3.3.1.1(3,7)]decane-1-amine
imported from: dron.owl

polyol
type: Class
subclass of: alcohol
definition: A compound that contains three or more hydroxyl groups.
id: CHEBI:26191
has_related_synonym: polyols
imported from: dron.owl

propanone
type: Class
subclass of: ketone
id: CHEBI:26292
imported from: dron.owl

amidine
type: Class
subclass of: nitrogen molecular entity
has_related_synonym: Amidines
id: CHEBI:2634
definition: Derivatives of oxoacids RnE(=O)OH in which the hydroxy group is replaced by an amino group and the oxo group is replaced by =NR. In organic chemistry an unspecified amidine is commonly a carboxamidine.
has_exact_synonym: amidine
has_related_synonym: amidines
has_exact_synonym: amidines
imported from: dron.owl

pteridines
type: Class
subclass of: organic heterobicyclic compound
subclass of: heteroarene
subclass of: organonitrogen heterocyclic compound
id: CHEBI:26373
imported from: dron.owl

purine alkaloid
type: Class
subclass of: alkaloid
subclass of: purines
id: CHEBI:26385
has_related_synonym: purine alkaloids
imported from: dron.owl

purine nucleoside
type: Class
subclass of: purines
subclass of: nucleoside
id: CHEBI:26394
has_exact_synonym: purine nucleoside
has_related_synonym: purine nucleosides
imported from: dron.owl

purines
type: Class
subclass of: imidazopyrimidine
definition: Any compound containing purine as part of its structure.
has_alternative_id: CHEBI:13678
id: CHEBI:26401
imported from: dron.owl

pyridinemonocarboxylic acid
type: Class
subclass of: monocarboxylic acid
subclass of: pyridines
id: CHEBI:26420
has_related_synonym: pyridinemonocarboxylic acids
imported from: dron.owl

pyridines
type: Class
subclass of: organic heteromonocyclic compound
subclass of: organonitrogen heterocyclic compound
id: CHEBI:26421
imported from: dron.owl

pyrimidine nucleoside
type: Class
subclass of: nucleoside
subclass of: pyrimidines
id: CHEBI:26440
has_related_synonym: pyrimidine nucleosides
imported from: dron.owl

pyrroles
type: Class
subclass of: organic heteromonocyclic compound
subclass of: organonitrogen heterocyclic compound
id: CHEBI:26455
imported from: dron.owl

quinolinemonocarboxylic acid
type: Class
subclass of: monocarboxylic acid
subclass of: quinolines
id: CHEBI:26512
has_related_synonym: quinolinemonocarboxylic acids
imported from: dron.owl

quinolines
type: Class
subclass of: organic heterobicyclic compound
definition: A class of aromatic heterocyclic compounds each of which contains a benzene ring ortho fused to carbons 2 and 3 of a pyridine ring.
id: CHEBI:26513
imported from: dron.owl

Amiodarone
type: Class
label: amiodarone
subclass of: organoiodine compound
subclass of: 1-benzofurans
has_exact_synonym: (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone
has_related_synonym: 2-Butyl-3-(3,5-diiodo-4-(2-diethylaminoethoxy)benzoyl)benzofuran
has_related_synonym: 2-Butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl ketone
has_related_synonym: 2-n-Butyl-3',5'-diiodo-4'-N-diethylaminoethoxy-3-benzoylbenzofuran
has_RxCUI: 703
definition: A 1-benzofuran that has formula C25H29I2NO3.
has_exact_synonym: Amiodarone
database_cross_reference: Beilstein:1271711
has_related_synonym: C25H29I2NO3
id: CHEBI:2663
database_cross_reference: ChemIDplus:1951-25-3
has_related_synonym: InChI=1S/C25H29I2NO3/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3
has_related_synonym: InChIKey=IYIKLHRQXLHMJQ-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:1951-25-3
database_cross_reference: KEGG COMPOUND:C06823
database_cross_reference: Wikipedia:Amiodarone
imported from: dron.owl

Amitriptyline
type: Class
label: amitriptyline
subclass of: tertiary amine
subclass of: tricyclic antidepressant
has_related_synonym: 10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5H-dibenzo(a,d)cycloheptene
has_related_synonym: 10,11-dihydro-N,N-dimethyl-5H-dibenzo(a,d)heptalene-Delta(5),gamma-propylamine
has_related_synonym: 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine
has_exact_synonym: 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine
has_related_synonym: 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethylpropan-1-amine
has_related_synonym: 5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptatriene
has_related_synonym: 5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene
has_related_synonym: 5-(gamma-dimethylaminopropylidene)-5H-dibenzo[a,d][1,4]cycloheptadiene
has_RxCUI: 704
definition: A tricyclic antidepressant that has formula C20H23N.
has_related_synonym: Amitriptylin
has_exact_synonym: Amitriptyline
database_cross_reference: Beilstein:2217885
has_related_synonym: C20H23N
id: CHEBI:2666
has_related_synonym: CN(C)CCC=C1c2ccccc2CCc2ccccc12
database_cross_reference: ChemIDplus:50-48-6
has_related_synonym: InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3
has_related_synonym: InChIKey=KRMDCWKBEZIMAB-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:50-48-6
database_cross_reference: KEGG COMPOUND:C06824
database_cross_reference: NIST Chemistry WebBook:50-48-6
database_cross_reference: Wikipedia:Amitriptyline
imported from: dron.owl

Amlodipine
type: Class
label: amlodipine
subclass of: organochlorine compound
subclass of: dihydropyridine
subclass of: Restriction
  on property: is_bearer_of
  some values from: function-inhibiting L-type voltage-gated calcium channel binding disposition
has_RxCUI: 17767
has_related_synonym: 3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
has_exact_synonym: 3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
definition: A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.
has_related_synonym: Amlodipine Free Base
database_cross_reference: Beilstein:3570229
has_related_synonym: C20H25ClN2O5
id: CHEBI:2668
database_cross_reference: ChemIDplus:88150-42-9
database_cross_reference: DrugBank:88150-42-9
database_cross_reference: DrugBank:DB00381
has_related_synonym: InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3
has_related_synonym: InChIKey=HTIQEAQVCYTUBX-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:88150-42-9
database_cross_reference: KEGG COMPOUND:C06825
database_cross_reference: KEGG DRUG:88150-42-9
database_cross_reference: KEGG DRUG:D07450
database_cross_reference: Patent:EP89167
database_cross_reference: Patent:US4572909
database_cross_reference: Wikipedia:Amlodipine
has_related_synonym: amlodipine
has_related_synonym: amlodipino
has_related_synonym: amlodipinum
imported from: dron.owl

steroid hormone
type: Class
subclass of: steroid
definition: Any steroid that act as hormone.
id: CHEBI:26764
has_related_synonym: Steroidhormon
has_related_synonym: Steroidhormone
has_related_synonym: hormona esteroide
has_related_synonym: hormonas esteroideas
has_related_synonym: hormone steroide
has_related_synonym: hormones steroides
has_related_synonym: steroid hormones
imported from: dron.owl

streptomycins
type: Class
subclass of: amino cyclitol glycoside
subclass of: aminoglycoside antibiotic
id: CHEBI:26788
imported from: dron.owl

sulfide
type: Class
subclass of: sulfur molecular entity
id: CHEBI:26822
imported from: dron.owl

sulfur molecular entity
type: Class
subclass of: chalcogen molecular entity
id: CHEBI:26835
has_related_synonym: sulfur molecular entities
has_exact_synonym: sulfur molecular entity
imported from: dron.owl

terpenoid
type: Class
subclass of: isoprenoid
definition: Any natural product or related compound formally derived from isoprene units. Terpenoids may contain oxygen in various functional groups. This class is subdivided according to the number of carbon atoms in the same manner as are terpenes. The skeleton of terpenoids may differ from strict additivity of isoprene units by the loss or shift of a fragment, generally a methyl group.
id: CHEBI:26873
has_exact_synonym: Terpenoid
has_related_synonym: terpenoide
has_related_synonym: terpenoides
has_exact_synonym: terpenoids
imported from: dron.owl

tertiary alcohol
type: Class
subclass of: alcohol
definition: A tertiary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has three other carbon atoms attached to it.
has_related_synonym: C4H7OR3
id: CHEBI:26878
has_related_synonym: OC(C[*])(C[*])C[*]
has_exact_synonym: tertiary alcohol
has_related_synonym: tertiary alcohols
imported from: dron.owl

oxolanes
type: Class
subclass of: organic heteromonocyclic compound
subclass of: oxacycle
definition: Any oxacycle having an oxolane (tetrahydrofuran) skeleton.
id: CHEBI:26912
imported from: dron.owl

organic heterotricyclic compound
type: Class
subclass of: heterotricyclic compound
subclass of: organic heteropolycyclic compound
subclass of: organic tricyclic compound
id: CHEBI:26979
has_related_synonym: heterotricyclic compounds
has_related_synonym: organic heterotricyclic compounds
imported from: dron.owl

anastrozole
type: Class
subclass of: nitrile
subclass of: triazoles
has_exact_synonym: 2,2'-[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]bis(2-methylpropanenitrile)
has_RxCUI: 84857
definition: A 1,2,4-triazole compound having a 3,5-bis(2-cyano-2-propyl)benzyl group at the 1-position.
has_related_synonym: Anastrozol
database_cross_reference: Beilstein:8005958
has_related_synonym: C17H19N5
has_related_synonym: CC(C)(C#N)c1cc(Cn2cncn2)cc(c1)C(C)(C)C#N
id: CHEBI:2704
database_cross_reference: ChemIDplus:120511-73-1
database_cross_reference: DrugBank:120511-73-1
database_cross_reference: DrugBank:DB01217
has_related_synonym: InChI=1S/C17H19N5/c1-16(2,9-18)14-5-13(8-22-12-20-11-21-22)6-15(7-14)17(3,4)10-19/h5-7,11-12H,8H2,1-4H3
has_related_synonym: InChIKey=YBBLVLTVTVSKRW-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:120511-73-1
database_cross_reference: KEGG COMPOUND:C08159
database_cross_reference: KEGG DRUG:120511-73-1
database_cross_reference: KEGG DRUG:D00960
database_cross_reference: Patent:EP296749
database_cross_reference: Patent:US4935437
database_cross_reference: Wikipedia:Anastrozole
has_related_synonym: alpha,alpha,alpha',alpha'-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrile
has_related_synonym: anastrozole
imported from: dron.owl

trimethylxanthine
type: Class
subclass of: methylxanthine
id: CHEBI:27134
has_related_synonym: trimethylxanthines
imported from: dron.owl

tryptamines
type: Class
subclass of: indoles
id: CHEBI:27162
definition: Tryptamine and its substitution derivatives.
imported from: dron.owl

organic heterobicyclic compound
type: Class
subclass of: organic heterocyclic compound
subclass of: heterobicyclic compound
id: CHEBI:27171
has_related_synonym: heterobicyclic compounds
has_related_synonym: organic heterobicyclic compounds
imported from: dron.owl

valine derivative
type: Class
subclass of: modified amino acid
id: CHEBI:27267
imported from: dron.owl

vinca alkaloid
type: Class
subclass of: indole alkaloid
definition: A group of indole-indoline dimers which are alkaloids obtained from the Vinca genus of plants.
id: CHEBI:27288
has_exact_synonym: vinca alkaloid
has_related_synonym: vinca alkaloids
has_related_synonym: vincaleukoblastines
imported from: dron.owl

Penicillin V
type: Class
label: phenoxymethylpenicillin
subclass of: penicillin
has_related_synonym: (2S,5R,6R)-3,3-DIMETHYL-7-OXO-6-(2-PHENOXYACETAMIDO)-4-THIA-1- AZABICYCLO(3.2.0)HEPTANE-2-CARBOXYLIC ACID
has_related_synonym: (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
has_exact_synonym: 2,2-dimethyl-6beta-[(phenoxyacetyl)amino]penam-3alpha-carboxylic acid
has_exact_synonym: 3,3-dimethyl-6beta-[(phenoxyacetyl)amino]penam-2alpha-carboxylic acid (PIN)
has_related_synonym: 6-phenoxyacetamidopenicillanic acid
has_RxCUI: 7984
definition: A penicillin compound having a 6beta-(phenoxyacetyl)amino side chain.
database_cross_reference: Beilstein:96259
has_related_synonym: C16H18N2O5S
has_alternative_id: CHEBI:25868
id: CHEBI:27446
has_alternative_id: CHEBI:44947
has_alternative_id: CHEBI:7966
database_cross_reference: ChemIDplus:87-08-1
database_cross_reference: CiteXplore:10930630
database_cross_reference: CiteXplore:12569987
database_cross_reference: CiteXplore:14687482
database_cross_reference: CiteXplore:16033609
database_cross_reference: CiteXplore:8566082
has_related_synonym: Fenospen
has_related_synonym: InChI=1S/C16H18N2O5S/c1-16(2)12(15(21)22)18-13(20)11(14(18)24-16)17-10(19)8-23-9-6-4-3-5-7-9/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/t11-,12+,14-/m1/s1
has_related_synonym: InChIKey=BPLBGHOLXOTWMN-MBNYWOFBSA-N
database_cross_reference: KEGG COMPOUND:87-08-1
database_cross_reference: KEGG COMPOUND:C08126
database_cross_reference: KEGG DRUG:D05411
has_related_synonym: Oracillin
database_cross_reference: PDBeChem:PNV
has_related_synonym: PV
has_related_synonym: Penicillin V
database_cross_reference: Reaxys:96259
has_related_synonym: V-Cillin
database_cross_reference: Wikipedia:Phenoxymethylpenicillin
has_related_synonym: fenoximetilpenicilina
has_related_synonym: penicillin phenoxymethyl
has_related_synonym: phenoxomethylpenicillin
has_related_synonym: phenoxymethylenepenicillinic acid
has_related_synonym: phenoxymethylpenicillin
has_related_synonym: phenoxymethylpenicilline
has_related_synonym: phenoxymethylpenicillinum
imported from: dron.owl

Caffeine
type: Class
label: caffeine
subclass of: trimethylxanthine
has_related_synonym: 1,3,7-trimethyl-2,6-dioxopurine
has_exact_synonym: 1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
has_related_synonym: 1,3,7-trimethylpurine-2,6-dione
has_related_synonym: 1,3,7-trimethylxanthine
has_related_synonym: 1-methyltheobromine
has_RxCUI: 1886
has_related_synonym: 3,7-Dihydro-1,3,7-trimethyl-1H-purin-2,6-dion
has_related_synonym: 7-methyltheophylline
definition: A trimethylxanthine that has formula C8H10N4O2.
database_cross_reference: Beilstein:17705
has_related_synonym: C8H10N4O2
has_exact_synonym: CAFFEINE
has_alternative_id: CHEBI:22982
id: CHEBI:27732
has_alternative_id: CHEBI:3295
has_alternative_id: CHEBI:41472
has_exact_synonym: Caffeine
database_cross_reference: ChemIDplus:58-08-2
has_related_synonym: Cn1cnc2n(C)c(=O)n(C)c(=O)c12
has_related_synonym: Coffein
database_cross_reference: DrugBank:DB00201
database_cross_reference: Gmelin:103040
has_related_synonym: InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3
has_related_synonym: InChIKey=RYYVLZVUVIJVGH-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:58-08-2
database_cross_reference: KEGG COMPOUND:C07481
database_cross_reference: KEGG DRUG:D00528
has_related_synonym: Koffein
database_cross_reference: NIST Chemistry WebBook:58-08-2
database_cross_reference: PDBeChem:CFF
has_related_synonym: Thein
database_cross_reference: Wikipedia:Caffeine
has_related_synonym: anhydrous caffeine
has_related_synonym: cafeina
has_related_synonym: cafeine
has_related_synonym: guaranine
has_related_synonym: mateina
has_related_synonym: methyltheobromine
has_related_synonym: teina
has_related_synonym: theine
imported from: dron.owl

Cisplatin
type: Class
label: cisplatin
subclass of: diamminedichloroplatinum
has_exact_synonym: (SP-4-2)-diamminedichloridoplatinum
has_exact_synonym: (SP-4-2)-diamminedichloroplatinum
has_RxCUI: 2555
definition: A platinum-containing anticancer drug that interacts with, and forms cross-links between, DNA and proteins. It is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary.
has_related_synonym: Briplatin
has_alternative_id: CHEBI:23314
id: CHEBI:27899
has_alternative_id: CHEBI:3722
database_cross_reference: ChemIDplus:15663-27-1
has_related_synonym: Cismaplat
has_exact_synonym: Cisplatin
has_related_synonym: Cl2H6N2Pt
database_cross_reference: DrugBank:DB00515
database_cross_reference: Gmelin:2519
has_related_synonym: H6Cl2N2Pt
has_related_synonym: InChI=1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2
has_related_synonym: InChIKey=LXZZYRPGZAFOLE-UHFFFAOYSA-L
database_cross_reference: KEGG COMPOUND:15663-27-1
database_cross_reference: KEGG COMPOUND:C06911
database_cross_reference: KEGG DRUG:D00275
has_related_synonym: Lederplatin
database_cross_reference: MolBase:25
has_related_synonym: Neoplatin
database_cross_reference: Patent:DE2318020
database_cross_reference: Patent:DE2329485
has_related_synonym: Peyrone's chloride
has_related_synonym: Peyrone's salt
has_related_synonym: Platamine
has_related_synonym: Platinex
has_related_synonym: Platinol
has_related_synonym: Randa
has_related_synonym: cis-DDP
has_related_synonym: cis-[PtCl2(NH3)2]
has_exact_synonym: cis-diamminedichloridoplatinum(II)
has_related_synonym: cis-diamminedichloroplatinum
has_exact_synonym: cis-diamminedichloroplatinum(II)
has_related_synonym: cis-diammineplatinum(II) dichloride
has_related_synonym: cis-dichlorodiammineplatinum(II)
has_related_synonym: cisplatin
has_related_synonym: cisplatine
has_related_synonym: cisplatino
has_related_synonym: cisplatinum
imported from: dron.owl

beta-lactam antibiotic
type: Class
subclass of: organonitrogen heterocyclic antibiotic
subclass of: beta-lactam
has_alternative_id: CHEBI:10427
has_alternative_id: CHEBI:22844
id: CHEBI:27933
imported from: dron.owl

Tobramycin
type: Class
label: tobramycin
subclass of: amino cyclitol glycoside
has_exact_synonym: (1S,2S,3R,4S,6R)-4,6-diamino-3-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyloxy)-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside
has_RxCUI: 10627
has_related_synonym: 3'-Deoxykanamycin B
definition: A amino cyclitol glycoside that is kanamycin B lacking the 3-hydroxy substituent from the 2,6-diaminoglucose ring.
has_related_synonym: C18H37N5O9
has_alternative_id: CHEBI:19849
id: CHEBI:28864
has_alternative_id: CHEBI:45933
has_alternative_id: CHEBI:9610
database_cross_reference: ChemIDplus:32986-56-4
database_cross_reference: CiteXplore:11000679
database_cross_reference: CiteXplore:11072877
database_cross_reference: CiteXplore:11459219
database_cross_reference: CiteXplore:11478352
database_cross_reference: CiteXplore:14961139
database_cross_reference: CiteXplore:15813341
database_cross_reference: CiteXplore:16205136
database_cross_reference: CiteXplore:16239129
database_cross_reference: CiteXplore:16478137
database_cross_reference: CiteXplore:16650821
database_cross_reference: CiteXplore:17150225
database_cross_reference: CiteXplore:18331849
database_cross_reference: CiteXplore:19072156
database_cross_reference: CiteXplore:19220547
database_cross_reference: CiteXplore:19340717
database_cross_reference: CiteXplore:19465435
database_cross_reference: CiteXplore:20000576
database_cross_reference: CiteXplore:20884302
database_cross_reference: CiteXplore:20938669
database_cross_reference: CiteXplore:21275493
database_cross_reference: CiteXplore:21343445
database_cross_reference: CiteXplore:21357290
database_cross_reference: CiteXplore:21396748
database_cross_reference: CiteXplore:21414310
database_cross_reference: CiteXplore:21429824
database_cross_reference: CiteXplore:21438171
database_cross_reference: CiteXplore:21530479
database_cross_reference: CiteXplore:21592592
database_cross_reference: CiteXplore:21726492
database_cross_reference: CiteXplore:21756818
database_cross_reference: CiteXplore:21796931
database_cross_reference: CiteXplore:21815282
has_related_synonym: InChI=1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1
has_related_synonym: InChIKey=NLVFBUXFDBBNBW-PBSUHMDJSA-N
database_cross_reference: KEGG COMPOUND:32986-56-4
database_cross_reference: KEGG COMPOUND:C00397
database_cross_reference: KEGG DRUG:D00063
has_related_synonym: Nebramycin 6
has_related_synonym: Nebramycin factir 6
has_related_synonym: O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-4))-2-deoxy-D-streptamine
database_cross_reference: PDBeChem:TOY
database_cross_reference: Reaxys:1357507
has_related_synonym: Tobracin (TN)
has_exact_synonym: Tobramycin
has_related_synonym: Tobrex (TN)
database_cross_reference: Wikipedia:Tobramycin
imported from: dron.owl

monocarboxylic acid amide
type: Class
subclass of: carboxamide
has_alternative_id: CHEBI:13211
has_alternative_id: CHEBI:22207
has_alternative_id: CHEBI:25383
id: CHEBI:29347
has_alternative_id: CHEBI:6977
has_exact_synonym: monocarboxylic acid amide
has_related_synonym: monocarboxylic acid amides
imported from: dron.owl

fatty amide
type: Class
subclass of: lipid
subclass of: monocarboxylic acid amide
definition: A monocarboxylic acid amide derived from a fatty acid.
has_related_synonym: Aliphatic amide
has_alternative_id: CHEBI:13247
has_alternative_id: CHEBI:22310
has_alternative_id: CHEBI:22330
has_alternative_id: CHEBI:2572
id: CHEBI:29348
has_alternative_id: CHEBI:35749
has_alternative_id: CHEBI:38838
has_related_synonym: CHNOR2
database_cross_reference: KEGG COMPOUND:C02244
database_cross_reference: LIPID MAPS:LMFA08
has_related_synonym: an aliphatic amide
has_exact_synonym: fatty amide
has_related_synonym: fatty amides
imported from: dron.owl

Betaxolol
type: Class
label: betaxolol
subclass of: propanolamine
subclass of: Restriction
  on property: is_bearer_of
  some values from: non-activating competitive beta-adrenergic receptor binding disposition
has_related_synonym: 1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-((1-methylethyl)amino)-2-propanol
has_related_synonym: 1-(isopropylamino)-3-[p-(cyclopropylmethoxyethyl)phenoxy]-2-propanol
has_exact_synonym: 1-{4-[2-(cyclopropylmethoxy)ethyl]phenoxy}-3-(propan-2-ylamino)propan-2-ol
has_RxCUI: 1520
definition: 3-Aminopropane-1,2-diol in which the hydrogen of the primary hydoxy is substituted by a 4-[2-(cyclopropylmethoxy)ethyl]phenyl group and one of the hydrogens attached to the amino group is substituted by isopropyl. It is a selective beta1-receptor blocker and is used in the treatment of glaucoma as well as hypertension, arrhythmias, and coronary heart disease. It is also used to reduce non-fatal cardiac events in patients with heart failure.
database_cross_reference: Beilstein:1991268
has_related_synonym: C18H29NO3
has_related_synonym: CC(C)NCC(O)COc1ccc(CCOCC2CC2)cc1
has_alternative_id: CHEBI:101354
id: CHEBI:3082
database_cross_reference: ChEMBL:101354
database_cross_reference: ChEMBL:10891117
database_cross_reference: ChEMBL:1361581
database_cross_reference: ChEMBL:14971904
database_cross_reference: ChEMBL:15993593
database_cross_reference: ChemIDplus:63659-18-7
database_cross_reference: DrugBank:DB00195
has_related_synonym: InChI=1S/C18H29NO3/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3
has_related_synonym: InChIKey=NWIUTZDMDHAVTP-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:63659-18-7
database_cross_reference: KEGG COMPOUND:C06849
database_cross_reference: KEGG DRUG:D07526
database_cross_reference: Patent:DE2649605
database_cross_reference: Patent:US4252984
database_cross_reference: Wikipedia:Betaxolol
has_related_synonym: betaxolol
has_related_synonym: betaxololum
imported from: dron.owl

alcohol
type: Class
subclass of: organic hydroxy compound
definition: A compound in which a hydroxy group, -OH, is attached to a saturated carbon atom.
has_exact_synonym: Alcohol
has_alternative_id: CHEBI:13804
has_alternative_id: CHEBI:22288
has_alternative_id: CHEBI:2553
id: CHEBI:30879
has_related_synonym: CHOR3
has_related_synonym: HOR
database_cross_reference: KEGG COMPOUND:C00069
has_related_synonym: OC([*])([*])[*]
has_exact_synonym: alcohols
imported from: dron.owl

bicalutamide
type: Class
subclass of: carboxamide
has_exact_synonym: (2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide
has_RxCUI: 83008
definition: A carboxamide that has formula C18H14F4N2O4S.
database_cross_reference: Beilstein:5364666
has_related_synonym: C18H14F4N2O4S
id: CHEBI:3090
has_related_synonym: Casodex
database_cross_reference: ChemIDplus:90357-06-5
database_cross_reference: DrugBank:DB01128
has_related_synonym: InChIKey=LKJPYSCBVHEWIU-KRWDZBQOSA-N
database_cross_reference: KEGG COMPOUND:C08160
database_cross_reference: KEGG DRUG:D00961
database_cross_reference: Patent:EP100172
database_cross_reference: Patent:US4636505
database_cross_reference: Wikipedia:Bicalutamide
has_related_synonym: bicalutamida
has_related_synonym: bicalutamide
has_related_synonym: bicalutamidum
imported from: dron.owl

Carboplatin
type: Class
label: carboplatin
subclass of: platinum coordination entity
has_exact_synonym: (SP-4-2)-diammine[cyclobutane-1,1-dicarboxylato(2-)-kappa(2)O,O']platinum
has_RxCUI: 40048
definition: A platinum coordination entity that has formula C6H12N2O4Pt.
has_related_synonym: C6H12N2O4Pt
has_related_synonym: C6H6O4Pt.2H3N
id: CHEBI:31355
has_exact_synonym: Carboplatin
database_cross_reference: ChemIDplus:41575-94-4
database_cross_reference: Gmelin:1044703
database_cross_reference: Gmelin:51428
has_related_synonym: InChI=1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2/p-2
has_related_synonym: InChIKey=OLESAACUTLOWQZ-UHFFFAOYSA-L
database_cross_reference: KEGG DRUG:41575-94-4
database_cross_reference: KEGG DRUG:D01363
has_related_synonym: Paraplatin
has_related_synonym: cbdca
has_related_synonym: cis-diammine(1,1-cyclobutanedicarboxylato)platinum
has_related_synonym: cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II)
imported from: dron.owl

ethylenediamine derivatives
type: Class
subclass of: organic amino compound
id: CHEBI:31577
imported from: dron.owl

Bromocriptine
type: Class
label: bromocriptine
subclass of: indole alkaloid
has_related_synonym: (5'alpha)-2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-3',6',18-trioxoergotaman
has_related_synonym: (5'alpha)-2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)ergotaman-3',6',18-trione
has_exact_synonym: (5'alpha)-2-bromo-12'-hydroxy-5'-(2-methylpropyl)-2'-(propan-2-yl)-3',6',18-trioxoergotaman
has_related_synonym: (5'alpha)-2-bromo-12'-hydroxy-5'-isobutyl-2'-isopropyl-3',6',18-trioxoergotaman
has_RxCUI: 1760
has_related_synonym: 2-bromo-alpha-ergocryptine
has_related_synonym: 2-bromo-alpha-ergokryptin
has_related_synonym: 2-bromo-alpha-ergokryptine
definition: An indole alkaloid that has formula C32H40BrN5O5.
database_cross_reference: Beilstein:741357
has_exact_synonym: Bromocriptine
has_related_synonym: C32H40BrN5O5
id: CHEBI:3181
database_cross_reference: ChemIDplus:25614-03-3
database_cross_reference: DrugBank:DB01200
has_related_synonym: InChI=1S/C32H40BrN5O5/c1-16(2)12-24-29(40)37-11-7-10-25(37)32(42)38(24)30(41)31(43-32,17(3)4)35-28(39)18-13-20-19-8-6-9-22-26(19)21(27(33)34-22)14-23(20)36(5)15-18/h6,8-9,13,16-18,23-25,34,42H,7,10-12,14-15H2,1-5H3,(H,35,39)/t18-,23-,24+,25+,31-,32+/m1/s1
has_related_synonym: InChIKey=OZVBMTJYIDMWIL-AYFBDAFISA-N
database_cross_reference: KEGG COMPOUND:25614-03-3
database_cross_reference: KEGG COMPOUND:C06856
database_cross_reference: KEGG DRUG:D03165
database_cross_reference: Patent:DE1926045
database_cross_reference: Patent:US3752814
database_cross_reference: Wikipedia:Bromocriptine
has_related_synonym: bromocriptine
has_related_synonym: bromocriptinum
has_related_synonym: bromocryptine
has_related_synonym: bromoergocriptine
imported from: dron.owl

oxaliplatin
type: Class
subclass of: platinum coordination entity
has_exact_synonym: (SP-4-2)[(1R,2R)-cyclohexane-1,2-diamine-kappa(2)N,N'][ethanedioato(2-)-kappa(2)O(1),O(2)]platinum
has_related_synonym: (SP-4-2-(1R-trans))-(1,2-cyclohexanediamine-N,N')(ethanedioato(2-)-O,O')platinum
has_RxCUI: 32592
definition: A platinum coordination entity that has formula C6H14N2.C2O4.Pt.
has_related_synonym: C6H14N2.C2O4.Pt
has_related_synonym: C8H14N2O4Pt
id: CHEBI:31941
database_cross_reference: ChemIDplus:63121-00-6
database_cross_reference: DrugBank:DB00526
has_related_synonym: Eloxatin
database_cross_reference: Gmelin:1046012
database_cross_reference: Gmelin:28892
has_related_synonym: InChI=1S/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/q;;+2/p-2/t5-,6-;;/m1../s1
has_related_synonym: InChIKey=ZROHGHOFXNOHSO-BNTLRKBRSA-L
database_cross_reference: KEGG COMPOUND:61825-94-3
database_cross_reference: KEGG COMPOUND:C13258
database_cross_reference: KEGG DRUG:D01790
has_exact_synonym: Oxaliplatin
has_related_synonym: oxalato(1,2-diaminocyclohexane)platinum(II)
has_related_synonym: oxaliplatin
has_related_synonym: oxaliplatine
has_related_synonym: oxaliplatino
has_related_synonym: oxaliplatinum
imported from: dron.owl

Bupropion
type: Class
label: bupropion
subclass of: propanone
has_exact_synonym: 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one
has_RxCUI: 42347
definition: A propanone that has formula C13H18ClNO.
has_exact_synonym: Bupropion
has_related_synonym: C13H18ClNO
has_related_synonym: CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1
id: CHEBI:3219
database_cross_reference: ChemIDplus:2101062
database_cross_reference: ChemIDplus:34911-55-2
has_related_synonym: InChI=1S/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3
has_related_synonym: InChIKey=SNPPWIUOZRMYNY-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:34841-39-9
database_cross_reference: KEGG COMPOUND:C06860
database_cross_reference: Wikipedia:Bupropion
imported from: dron.owl

Buspirone
type: Class
label: buspirone
subclass of: azaspiro compound
subclass of: pyrimidines
subclass of: N-alkylpiperazine
subclass of: N-arylpiperazine
has_RxCUI: 1827
has_related_synonym: 8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione
has_exact_synonym: 8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione
definition: An azaspiro compound that has formula C21H31N5O2.
database_cross_reference: Beilstein:964904
has_exact_synonym: Buspirone
has_related_synonym: C21H31N5O2
id: CHEBI:3223
database_cross_reference: ChemIDplus:36505-84-7
database_cross_reference: DrugBank:DB00490
has_related_synonym: InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2
has_related_synonym: InChIKey=QWCRAEMEVRGPNT-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:36505-84-7
database_cross_reference: KEGG COMPOUND:C06861
database_cross_reference: KEGG DRUG:D07593
database_cross_reference: Patent:DE2057845
database_cross_reference: Patent:US3717634
database_cross_reference: Wikipedia:Buspirone
has_related_synonym: buspirona
has_related_synonym: buspirone
has_related_synonym: buspironum
imported from: dron.owl

tertiary amine
type: Class
subclass of: amine
subclass of: tertiary amino compound
definition: A compound formally derived from ammonia by replacing three hydrogen atoms by hydrocarbyl groups.
has_alternative_id: CHEBI:26879
id: CHEBI:32876
has_alternative_id: CHEBI:9458
database_cross_reference: KEGG COMPOUND:C02196
has_related_synonym: NR3
has_related_synonym: R3N
has_exact_synonym: Tertiary amine
has_related_synonym: [*]N([*])[*]
has_related_synonym: tertiaeres Amin
has_exact_synonym: tertiary amines
imported from: dron.owl

primary amine
type: Class
subclass of: amine
subclass of: primary amino compound
definition: A compound formally derived from ammonia by replacing one hydrogen atom by a hydrocarbyl group.
has_alternative_id: CHEBI:26263
has_alternative_id: CHEBI:26265
id: CHEBI:32877
has_alternative_id: CHEBI:8407
has_alternative_id: CHEBI:8409
has_related_synonym: H2NR
database_cross_reference: KEGG COMPOUND:C00893
database_cross_reference: KEGG COMPOUND:C02580
has_related_synonym: N[*]
has_exact_synonym: Primary amine
has_related_synonym: Primary monoamine
has_related_synonym: R-NH2
has_related_synonym: primaeres Amin
has_exact_synonym: primary amines
imported from: dron.owl

amine
type: Class
subclass of: organic amino compound
definition: A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.
has_related_synonym: Amin
has_exact_synonym: Amine
has_alternative_id: CHEBI:13814
has_alternative_id: CHEBI:22474
has_alternative_id: CHEBI:2641
id: CHEBI:32952
database_cross_reference: KEGG COMPOUND:C00706
has_exact_synonym: amines
has_related_synonym: an amine
imported from: dron.owl

amide
type: Class
subclass of: nitrogen molecular entity
has_exact_synonym: Amide
definition: An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group.
has_alternative_id: CHEBI:22473
has_alternative_id: CHEBI:2633
id: CHEBI:32988
database_cross_reference: KEGG COMPOUND:C00241
has_exact_synonym: amides
imported from: dron.owl

coordination entity
type: Class
subclass of: heteroatomic molecular entity
definition: An assembly consisting of a central atom (usually metallic) to which is attached a surrounding array of other groups of atoms (ligands).
id: CHEBI:33240
has_related_synonym: coordination compounds
has_exact_synonym: coordination entities
has_exact_synonym: coordination entity
imported from: dron.owl

oxoacid derivative
type: Class
subclass of: heteroatomic molecular entity
id: CHEBI:33241
has_related_synonym: oxoacid derivatives
imported from: dron.owl

primary amide
type: Class
subclass of: amide
definition: A derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group.
id: CHEBI:33256
has_exact_synonym: primary amide
has_exact_synonym: primary amides
imported from: dron.owl

organosulfur compound
type: Class
subclass of: sulfur molecular entity
subclass of: organochalcogen compound
definition: An organosulfur compound is a compound containing at least one carbon-sulfur bond.
has_alternative_id: CHEBI:23010
has_alternative_id: CHEBI:25714
id: CHEBI:33261
database_cross_reference: Wikipedia:Organosulfur_compounds
has_exact_synonym: organosulfur compound
has_related_synonym: organosulfur compounds
imported from: dron.owl

heteroorganic entity
type: Class
subclass of: organic molecular entity
definition: A heteroorganic entity is an organic molecular entity in which carbon atoms or organic groups are bonded directly to one or more heteroatoms.
id: CHEBI:33285
has_related_synonym: heteroorganic entities
has_related_synonym: organoelement compounds
imported from: dron.owl

pnictogen molecular entity
type: Class
subclass of: p-block molecular entity
id: CHEBI:33302
has_related_synonym: pnictogen molecular entities
has_exact_synonym: pnictogen molecular entity
imported from: dron.owl

chalcogen molecular entity
type: Class
subclass of: p-block molecular entity
definition: Any p-block molecular entity containing a chalcogen.
id: CHEBI:33304
has_related_synonym: chalcogen compounds
has_related_synonym: chalcogen molecular entities
has_exact_synonym: chalcogen molecular entity
imported from: dron.owl

carboxylic ester
type: Class
subclass of: ester
subclass of: carbonyl compound
definition: An ester of a carboxylic acid.
has_alternative_id: CHEBI:13204
has_alternative_id: CHEBI:23028
id: CHEBI:33308
has_alternative_id: CHEBI:3408
has_related_synonym: CO2R2
has_exact_synonym: Carboxylic ester
database_cross_reference: KEGG COMPOUND:C02391
has_related_synonym: carboxylic acid esters
has_exact_synonym: carboxylic ester
has_exact_synonym: carboxylic esters
imported from: dron.owl

sulfur oxoacid derivative
type: Class
subclass of: sulfur molecular entity
subclass of: oxoacid derivative
id: CHEBI:33424
has_exact_synonym: sulfur oxoacid derivative
has_related_synonym: sulfur oxoacid derivatives
imported from: dron.owl

transition element molecular entity
type: Class
subclass of: molecular entity
definition: A molecular entity containing one or more atoms of a transition element.
id: CHEBI:33497
has_related_synonym: transition element molecular entities
has_related_synonym: transition metal molecular entity
imported from: dron.owl

sulfonic acid derivative
type: Class
subclass of: sulfur oxoacid derivative
id: CHEBI:33552
has_related_synonym: derivatives of sulfonic acid
has_exact_synonym: sulfonic acid derivative
has_related_synonym: sulfonic acid derivatives
imported from: dron.owl

carboxylic acid
type: Class
subclass of: oxoacid
subclass of: carbonyl compound
subclass of: organic molecular entity
definition: An oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid.
has_alternative_id: CHEBI:13428
has_alternative_id: CHEBI:13627
has_alternative_id: CHEBI:23027
id: CHEBI:33575
has_related_synonym: CHO2R
has_related_synonym: Carbonsaeure
has_related_synonym: Carbonsaeuren
database_cross_reference: CiteXplore:17147560
database_cross_reference: CiteXplore:18433345
has_related_synonym: Karbonsaeure
has_related_synonym: OC([*])=O
has_related_synonym: RC(=O)OH
has_related_synonym: acide carboxylique
has_related_synonym: acides carboxyliques
has_related_synonym: acido carboxilico
has_related_synonym: acidos carboxilicos
has_exact_synonym: carboxylic acid
has_exact_synonym: carboxylic acids
imported from: dron.owl

main group molecular entity
type: Class
subclass of: molecular entity
definition: A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table.
id: CHEBI:33579
has_related_synonym: main group compounds
has_related_synonym: main group molecular entities
imported from: dron.owl

carbon group molecular entity
type: Class
subclass of: p-block molecular entity
id: CHEBI:33582
has_related_synonym: carbon group molecular entities
has_exact_synonym: carbon group molecular entity
imported from: dron.owl

cyclic compound
type: Class
subclass of: polyatomic entity
id: CHEBI:33595
has_related_synonym: cyclic compounds
imported from: dron.owl

homocyclic compound
type: Class
subclass of: cyclic compound
definition: A cyclic compound having as ring members atoms of the same element only.
id: CHEBI:33597
has_exact_synonym: homocyclic compound
has_exact_synonym: homocyclic compounds
has_related_synonym: isocyclic compounds
imported from: dron.owl

carbocyclic compound
type: Class
subclass of: homocyclic compound
subclass of: organic cyclic compound
definition: A cyclic compound in which all of the ring members are carbon atoms.
id: CHEBI:33598
has_related_synonym: carbocycle
has_exact_synonym: carbocyclic compound
has_exact_synonym: carbocyclic compounds
imported from: dron.owl

spiro compound
type: Class
subclass of: polycyclic compound
definition: A compound having one atom as the only common member of two rings.
id: CHEBI:33599
has_exact_synonym: spiro compound
has_exact_synonym: spiro compounds
has_related_synonym: spiro-fused compounds
has_related_synonym: spirofused compounds
imported from: dron.owl

hydrogen molecular entity
type: Class
subclass of: s-block molecular entity
id: CHEBI:33608
has_related_synonym: hydrogen compounds
has_related_synonym: hydrogen molecular entities
imported from: dron.owl

polycyclic compound
type: Class
subclass of: cyclic compound
id: CHEBI:33635
has_related_synonym: polycyclic compounds
imported from: dron.owl

bicyclic compound
type: Class
subclass of: cyclic compound
definition: A molecule that features two fused rings.
id: CHEBI:33636
has_related_synonym: bicyclic compounds
imported from: dron.owl

aliphatic compound
type: Class
subclass of: organic molecular entity
definition: Any acyclic or cyclic, saturated or unsaturated carbon compound, excluding aromatic compounds.
id: CHEBI:33653
has_exact_synonym: aliphatic compounds
imported from: dron.owl

alicyclic compound
type: Class
subclass of: carbocyclic compound
subclass of: aliphatic compound
definition: An aliphatic compound having a carbocyclic ring structure which may be saturated or unsaturated, but may not be a benzenoid or other aromatic system.
id: CHEBI:33654
has_exact_synonym: alicyclic compounds
imported from: dron.owl

aromatic compound
type: Class
subclass of: cyclic compound
definition: A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekule structure) is said to possess aromatic character.
id: CHEBI:33655
has_exact_synonym: aromatic compounds
has_exact_synonym: aromatic molecular entity
has_related_synonym: aromatics
has_related_synonym: aromatische Verbindungen
imported from: dron.owl

organic aromatic compound
type: Class
subclass of: aromatic compound
subclass of: organic cyclic compound
id: CHEBI:33659
has_related_synonym: organic aromatic compounds
imported from: dron.owl

monocyclic compound
type: Class
subclass of: cyclic compound
id: CHEBI:33661
has_related_synonym: monocyclic compounds
imported from: dron.owl

heteromonocyclic compound
type: Class
subclass of: monocyclic compound
subclass of: heterocyclic compound
id: CHEBI:33670
has_exact_synonym: heteromonocyclic compound
has_exact_synonym: heteromonocyclic compounds
imported from: dron.owl

heteropolycyclic compound
type: Class
subclass of: polycyclic compound
subclass of: heterocyclic compound
id: CHEBI:33671
has_exact_synonym: heteropolycyclic compounds
has_related_synonym: polyheterocyclic compounds
imported from: dron.owl

heterobicyclic compound
type: Class
subclass of: bicyclic compound
subclass of: heterocyclic compound
definition: A bicyclic compound in which at least one of the rings contains at least one skeletal heteroatom.
id: CHEBI:33672
has_exact_synonym: heterobicyclic compounds
imported from: dron.owl

s-block molecular entity
type: Class
subclass of: main group molecular entity
definition: An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element.
id: CHEBI:33674
has_related_synonym: s-block compounds
has_related_synonym: s-block molecular entities
has_exact_synonym: s-block molecular entity
imported from: dron.owl

p-block molecular entity
type: Class
subclass of: main group molecular entity
definition: A p-block molecular entity is a molecular entity containing one or more atoms of a p-block element.
id: CHEBI:33675
has_related_synonym: p-block compounds
has_related_synonym: p-block molecular entities
has_related_synonym: p-block molecular entitiy
imported from: dron.owl

d-block molecular entity
type: Class
subclass of: transition element molecular entity
definition: A d-block molecular entity is a molecular entity containing one or more atoms of a d-block element.
id: CHEBI:33676
has_related_synonym: d-block compounds
has_related_synonym: d-block molecular entities
has_exact_synonym: d-block molecular entity
imported from: dron.owl

amino acid
type: Class
subclass of: carboxylic acid
subclass of: organic amino compound
definition: A carboxylic acid containing one or more amino groups.
has_related_synonym: Aminocarbonsaeure
has_related_synonym: Aminokarbonsaeure
has_related_synonym: Aminosaeure
has_alternative_id: CHEBI:13815
has_alternative_id: CHEBI:22477
id: CHEBI:33709
has_related_synonym: amino acids
imported from: dron.owl

Capsaicin
type: Class
label: capsaicin
subclass of: capsaicinoid
has_exact_synonym: (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide
has_related_synonym: (E)-8-Methyl-N-vanillyl-6-nonenamide
has_RxCUI: 1992
definition: A capsaicinoid that has formula C18H27NO3.
database_cross_reference: Beilstein:2816484
has_related_synonym: C18H27NO3
id: CHEBI:3374
has_related_synonym: COc1cc(CNC(=O)CCCC\C=C\C(C)C)ccc1O
has_exact_synonym: Capsaicin
database_cross_reference: ChemIDplus:404-86-4
has_related_synonym: InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+
has_related_synonym: InChIKey=YKPUWZUDDOIDPM-SOFGYWHQSA-N
has_related_synonym: Isodecenoic acid vanillylamide
database_cross_reference: KEGG COMPOUND:404-86-4
database_cross_reference: KEGG COMPOUND:C06866
database_cross_reference: KEGG DRUG:D00250
database_cross_reference: Wikipedia:Capsaicin
has_related_synonym: Zostrix
has_related_synonym: trans-8-Methyl-N-vanillyl-6-nonenamide
imported from: dron.owl

copper group molecular entity
type: Class
subclass of: transition element molecular entity
subclass of: d-block molecular entity
id: CHEBI:33745
has_related_synonym: copper group molecular entities
has_exact_synonym: copper group molecular entity
imported from: dron.owl

nickel group molecular entity
type: Class
subclass of: transition element molecular entity
subclass of: d-block molecular entity
id: CHEBI:33747
has_related_synonym: nickel group molecular entities
has_exact_synonym: nickel group molecular entity
imported from: dron.owl

platinum molecular entity
type: Class
subclass of: nickel group molecular entity
id: CHEBI:33749
has_related_synonym: platinum compounds
has_related_synonym: platinum molecular entities
has_exact_synonym: platinum molecular entity
imported from: dron.owl

organic hydroxy compound
type: Class
subclass of: hydroxides
subclass of: organic molecular entity
definition: An organic compound having at least one hydroxy group attached to a carbon atom.
id: CHEBI:33822
has_exact_synonym: hydroxy compounds
has_related_synonym: organic hydroxy compounds
imported from: dron.owl

organic cyclic compound
type: Class
subclass of: organic molecular entity
id: CHEBI:33832
has_related_synonym: organic cyclic compounds
imported from: dron.owl

heteroarene
type: Class
subclass of: organic heterocyclic compound
subclass of: organic aromatic compound
definition: A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2).
id: CHEBI:33833
has_related_synonym: hetarenes
has_exact_synonym: heteroarenes
imported from: dron.owl

benzenoid aromatic compound
type: Class
subclass of: carbocyclic compound
subclass of: organic aromatic compound
id: CHEBI:33836
has_related_synonym: benzenoid aromatic compounds
has_related_synonym: benzenoid compound
imported from: dron.owl

nucleoside
type: Class
subclass of: N-glycosyl compound
subclass of: oxolanes
subclass of: nucleobase-containing molecular entity
has_related_synonym: C5H9O4R
has_alternative_id: CHEBI:13661
has_alternative_id: CHEBI:25611
id: CHEBI:33838
has_alternative_id: CHEBI:7647
database_cross_reference: KEGG COMPOUND:C00801
has_exact_synonym: Nucleoside
definition: Nucleosides are ribosyl or deoxyribosyl derivatives of the pyrimidine or purine bases adenine, guanine, xanthine, thymine, cytosine, and uracil.
has_exact_synonym: nucleoside
has_related_synonym: nucleosides
has_exact_synonym: nucleosides
imported from: dron.owl

phenols
type: Class
subclass of: organic hydroxy compound
has_related_synonym: Aryl alcohol
has_alternative_id: CHEBI:13664
has_alternative_id: CHEBI:13825
has_alternative_id: CHEBI:25969
has_alternative_id: CHEBI:2857
id: CHEBI:33853
definition: Compounds having one or more hydroxy groups attached to a benzene or other arene ring.
database_cross_reference: KEGG COMPOUND:C15584
database_cross_reference: MetaCyc:Aryl-Alcohol
has_related_synonym: arenols
has_related_synonym: aryl alcohol
has_exact_synonym: phenols
imported from: dron.owl

aromatic amine
type: Class
subclass of: amine
subclass of: organic aromatic compound
definition: An amine in which the amino group is linked directly to an aromatic system.
has_alternative_id: CHEBI:22622
has_alternative_id: CHEBI:2834
id: CHEBI:33860
has_related_synonym: aromatic amines
imported from: dron.owl

transition element coordination entity
type: Class
subclass of: coordination entity
subclass of: transition element molecular entity
id: CHEBI:33861
has_related_synonym: transition element coordination entities
has_related_synonym: transition metal coordination compounds
has_related_synonym: transition metal coordination entities
imported from: dron.owl

platinum coordination entity
type: Class
subclass of: platinum molecular entity
subclass of: transition element coordination entity
id: CHEBI:33862
has_related_synonym: platinum coordination compounds
has_related_synonym: platinum coordination entities
has_exact_synonym: platinum coordination entity
imported from: dron.owl

gold molecular entity
type: Class
subclass of: copper group molecular entity
id: CHEBI:33969
has_related_synonym: gold compounds
has_related_synonym: gold molecular entities
has_exact_synonym: gold molecular entity
imported from: dron.owl

gold coordination entity
type: Class
subclass of: transition element coordination entity
subclass of: gold molecular entity
id: CHEBI:33971
has_related_synonym: gold coordination compounds
has_related_synonym: gold coordination entities
imported from: dron.owl

benzofurans
type: Class
subclass of: organic heterobicyclic compound
subclass of: oxacycle
has_alternative_id: CHEBI:22721
id: CHEBI:35259
imported from: dron.owl

carbopolycyclic compound
type: Class
subclass of: carbocyclic compound
subclass of: homopolycyclic compound
definition: A polyclic compound in which all of the ring members are carbon atoms.
id: CHEBI:35294
has_related_synonym: carbopolycyclic compounds
imported from: dron.owl

homopolycyclic compound
type: Class
subclass of: homocyclic compound
subclass of: polycyclic compound
id: CHEBI:35295
has_related_synonym: homopolycyclic compounds
imported from: dron.owl

hexoside
type: Class
subclass of: glycoside
id: CHEBI:35313
has_exact_synonym: hexoside
has_related_synonym: hexosides
imported from: dron.owl

steroid
type: Class
subclass of: lipid
subclass of: organic polycyclic compound
definition: Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from triterpenoids.
has_alternative_id: CHEBI:13687
has_alternative_id: CHEBI:26768
id: CHEBI:35341
has_alternative_id: CHEBI:9263
database_cross_reference: KEGG COMPOUND:C00377
has_exact_synonym: Steroid
has_related_synonym: a steroid
has_exact_synonym: steroids
imported from: dron.owl

17alpha-hydroxy steroid
type: Class
subclass of: 17-hydroxy steroid
has_related_synonym: 17-alpha-Hydroxysteroid
has_related_synonym: 17alpha-hydroxy steroids
has_alternative_id: CHEBI:13585
has_alternative_id: CHEBI:19174
id: CHEBI:35342
has_alternative_id: CHEBI:782
database_cross_reference: KEGG COMPOUND:C03336
has_related_synonym: a 17alpha-hydroxysteroid
imported from: dron.owl

21-hydroxy steroid
type: Class
subclass of: hydroxy steroid
has_related_synonym: 21-Hydroxysteroid
has_related_synonym: 21-hydroxy steroids
has_related_synonym: 21-hydroxysteroids
has_alternative_id: CHEBI:1300
has_alternative_id: CHEBI:13596
has_alternative_id: CHEBI:19803
id: CHEBI:35344
database_cross_reference: KEGG COMPOUND:C02506
has_related_synonym: a 21-hydroxysteroid
imported from: dron.owl

11beta-hydroxy steroid
type: Class
subclass of: 11-hydroxy steroid
has_related_synonym: 11beta-Hydroxysteroid
has_related_synonym: 11beta-hydroxy steroids
has_related_synonym: 11beta-hydroxysteroids
has_alternative_id: CHEBI:13774
has_alternative_id: CHEBI:19134
id: CHEBI:35346
has_alternative_id: CHEBI:738
database_cross_reference: KEGG COMPOUND:C01058
has_related_synonym: an 11beta-hydroxysteroid
imported from: dron.owl

hydroxy steroid
type: Class
subclass of: alcohol
subclass of: steroid
has_alternative_id: CHEBI:24748
id: CHEBI:35350
has_alternative_id: CHEBI:5814
has_related_synonym: Hydroxysteroid
database_cross_reference: KEGG COMPOUND:C02159
has_related_synonym: hydroxy steroids
has_related_synonym: hydroxysteroids
imported from: dron.owl

organonitrogen compound
type: Class
subclass of: heteroorganic entity
subclass of: nitrogen molecular entity
definition: Any heteroorganic entity containing at least one carbon-nitrogen bond.
id: CHEBI:35352
has_exact_synonym: organonitrogen compounds
has_related_synonym: organonitrogens
imported from: dron.owl

sulfonamide
type: Class
subclass of: primary amide
subclass of: sulfonic acid derivative
definition: An amide of a sulfonic acid RS(=O)2NR'2.
id: CHEBI:35358
database_cross_reference: CiteXplore:2434548
has_related_synonym: NO2SR3
has_related_synonym: [*]S(=O)(=O)N([*])[*]
has_related_synonym: sulfonamides
has_exact_synonym: sulfonamides
imported from: dron.owl

carboxamidine
type: Class
subclass of: amidine
subclass of: organonitrogen compound
has_related_synonym: Amidines
id: CHEBI:35359
definition: Compounds having the structure RC(=NR)NR2. The term is used as a suffix in systematic nomenclature to denote the -C(=NH)NH2 group including its carbon atom.
database_cross_reference: KEGG COMPOUND:C06060
has_exact_synonym: carboxamidines
has_related_synonym: carboxamidines
imported from: dron.owl

hydrazide
type: Class
subclass of: nitrogen molecular entity
id: CHEBI:35362
definition: Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).
has_related_synonym: hydrazides
has_exact_synonym: hydrazides
imported from: dron.owl

carbohydrazide
type: Class
subclass of: organonitrogen compound
subclass of: hydrazide
definition: A hydrazide consisting of hydrazine carrying one or more carboacyl groups.
id: CHEBI:35363
has_related_synonym: carbohydrazides
has_exact_synonym: carbohydrazides
imported from: dron.owl

D-glucoside
type: Class
subclass of: glucoside
has_related_synonym: C6H11O6R
has_alternative_id: CHEBI:21009
id: CHEBI:35436
has_alternative_id: CHEBI:4173
has_exact_synonym: D-Glucoside
has_related_synonym: D-glucosides
database_cross_reference: KEGG COMPOUND:C01798
imported from: dron.owl

organic disulfide
type: Class
subclass of: organosulfur compound
subclass of: disulfide
id: CHEBI:35489
definition: Compounds of structure RSSR in which R and R' are organic groups.
has_related_synonym: S2R2
has_related_synonym: [*]SS[*]
has_exact_synonym: disulfides
has_related_synonym: organic disulfides
imported from: dron.owl

addition compound
type: Class
subclass of: heteroatomic molecular entity
definition: An addition compound contains two or more simpler compounds that can be packed in a definite ratio into a crystal. The term covers donor-acceptor complexes (adducts) and a variety of lattice compounds.
id: CHEBI:35504
has_related_synonym: addition compounds
imported from: dron.owl

hydrate
type: Class
subclass of: addition compound
definition: An addition compound that contains water in weak chemical combination with another compound.
id: CHEBI:35505
has_related_synonym: Hydrat
has_related_synonym: hidrato
has_related_synonym: hidratos
has_related_synonym: hydrates
imported from: dron.owl

propanolamine
type: Class
subclass of: amino alcohol
id: CHEBI:35533
has_exact_synonym: propanolamine
has_related_synonym: propanolamines
imported from: dron.owl

aromatic ether
type: Class
subclass of: ether
id: CHEBI:35618
imported from: dron.owl

azaspiro compound
type: Class
subclass of: spiro compound
subclass of: organonitrogen heterocyclic compound
definition: An azaspiro compound is a spiro compound in which at least one of the cyclic components is a nitrogen heterocyle.
id: CHEBI:35624
has_exact_synonym: azaspiro compound
has_related_synonym: azaspiro compounds
imported from: dron.owl

beta-lactam
type: Class
subclass of: lactam
definition: A beta-lactam is a lactam in which the amide bond is contained within a four-membered ring, which includes the amide nitrogen and the carbonyl carbon.
has_alternative_id: CHEBI:10426
has_alternative_id: CHEBI:22845
id: CHEBI:35627
database_cross_reference: KEGG COMPOUND:C01866
has_exact_synonym: beta-Lactam
has_exact_synonym: beta-lactam
has_related_synonym: beta-lactams
imported from: dron.owl

secondary alcohol
type: Class
subclass of: alcohol
definition: A secondary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has two other carbon atoms attached to it.
has_related_synonym: C3H6OR2
has_alternative_id: CHEBI:13425
has_alternative_id: CHEBI:13686
has_alternative_id: CHEBI:26617
id: CHEBI:35681
has_alternative_id: CHEBI:58662
has_alternative_id: CHEBI:8741
has_alternative_id: CHEBI:9077
database_cross_reference: KEGG COMPOUND:C00432
database_cross_reference: KEGG COMPOUND:C01612
has_related_synonym: R-CHOH-R'
has_exact_synonym: Secondary alcohol
has_related_synonym: [H]C(O)(C[*])C[*]
has_exact_synonym: secondary alcohol
has_related_synonym: secondary alcohols
imported from: dron.owl

tetrazoles
type: Class
subclass of: organic heteromonocyclic compound
subclass of: organonitrogen heterocyclic compound
id: CHEBI:35689
imported from: dron.owl

dicarboxylic acid
type: Class
subclass of: carboxylic acid
definition: An oxoacid containing two carboxy groups.
has_related_synonym: C2H2O4R
has_alternative_id: CHEBI:23692
id: CHEBI:35692
has_alternative_id: CHEBI:4501
has_exact_synonym: Dicarboxylic acid
database_cross_reference: KEGG COMPOUND:C02028
has_related_synonym: dicarboxylic acids
imported from: dron.owl

ester
type: Class
subclass of: organic molecular entity
definition: A compound formally derived from an oxoacid RkE(=O)l(OH)m (l > 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter.
has_alternative_id: CHEBI:23960
id: CHEBI:35701
has_alternative_id: CHEBI:4859
has_exact_synonym: Ester
database_cross_reference: KEGG COMPOUND:C00287
has_related_synonym: esters
imported from: dron.owl

nitro compound
type: Class
subclass of: nitrogen molecular entity
definition: A compound having the nitro group, -NO2 (free valence on nitrogen), which may be attached to carbon, nitrogen (as in nitramines), or oxygen (as in nitrates), among other elements (in the absence of specification, C-nitro compounds are usually implied).
id: CHEBI:35715
has_exact_synonym: nitro compounds
imported from: dron.owl

C-nitro compound
type: Class
subclass of: nitro compound
definition: A compound having the nitro group (-NO2) attached to carbon atom.
has_exact_synonym: C-nitro compounds
id: CHEBI:35716
imported from: dron.owl

triazoles
type: Class
subclass of: organic heteromonocyclic compound
subclass of: organonitrogen heterocyclic compound
id: CHEBI:35727
has_related_synonym: triazole compounds
imported from: dron.owl

fatty acid ester
type: Class
subclass of: lipid
subclass of: carboxylic ester
has_alternative_id: CHEBI:27315
has_alternative_id: CHEBI:35747
id: CHEBI:35748
has_related_synonym: fatty acid esters
imported from: dron.owl

oxo steroid
type: Class
subclass of: ketone
subclass of: steroid
has_alternative_id: CHEBI:24979
has_alternative_id: CHEBI:25804
id: CHEBI:35789
has_related_synonym: keto steroids
has_related_synonym: ketosteroids
has_related_synonym: oxo steroids
has_related_synonym: oxosteroids
imported from: dron.owl

oxazole
type: Class
subclass of: organic heteromonocyclic compound
subclass of: organonitrogen heterocyclic compound
subclass of: oxacycle
definition: A compound based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.
id: CHEBI:35790
has_exact_synonym: oxazole
has_related_synonym: oxazoles
imported from: dron.owl

sulfoxide
type: Class
subclass of: organosulfur compound
id: CHEBI:35813
definition: Compounds having the structure R2S=O (R =/= H).
has_exact_synonym: sulfoxide
has_related_synonym: sulfoxides
imported from: dron.owl

sulfone
type: Class
subclass of: organosulfur compound
id: CHEBI:35850
definition: Compounds having the structure RS(=O)2R (R =/= H).
has_exact_synonym: sulfone
has_related_synonym: sulfones
imported from: dron.owl

hydroxy monocarboxylic acid
type: Class
subclass of: hydroxy carboxylic acid
subclass of: monocarboxylic acid
id: CHEBI:35868
has_related_synonym: hydroxy acid
has_related_synonym: hydroxy monocarboxylic acids
imported from: dron.owl

oxo monocarboxylic acid
type: Class
subclass of: monocarboxylic acid
subclass of: oxo carboxylic acid
definition: Any monocarboxylic acid having at least one additional oxo functional group.
id: CHEBI:35871
has_related_synonym: oxo monocarboxylic acids
imported from: dron.owl

imidazopyrimidine
type: Class
subclass of: organic heterobicyclic compound
subclass of: heteroarene
subclass of: organonitrogen heterocyclic compound
id: CHEBI:35875
has_related_synonym: imidazopyrimidines
imported from: dron.owl

dihydroxy monocarboxylic acid
type: Class
subclass of: hydroxy monocarboxylic acid
id: CHEBI:35972
has_related_synonym: dihydroxy monocarboxylic acids
imported from: dron.owl

penams
type: Class
subclass of: organic heterobicyclic compound
subclass of: beta-lactam antibiotic
subclass of: organonitrogen heterocyclic compound
subclass of: organosulfur heterocyclic compound
id: CHEBI:35992
definition: Natural and synthetic antibiotics containing the 4-thia-1-azabicyclo[3.2.0]heptan-7-one structure, generally assumed to have the 5R configuration unless otherwise specified.
has_exact_synonym: penams
imported from: dron.owl

quinone
type: Class
subclass of: cyclic ketone
subclass of: organic molecular entity
has_alternative_id: CHEBI:13684
has_alternative_id: CHEBI:26517
id: CHEBI:36141
has_related_synonym: Chinon
definition: Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included).
database_cross_reference: Wikipedia:Quinone
has_related_synonym: a quinone
has_exact_synonym: quinone
has_exact_synonym: quinones
has_related_synonym: quinones
imported from: dron.owl

dicarboxylic acid monoester
type: Class
subclass of: carboxylic ester
definition: A monoester of a dicarboxylic acid.
id: CHEBI:36244
has_related_synonym: dicarboxylic acid monoesters
imported from: dron.owl

polyatomic entity
type: Class
subclass of: molecular entity
definition: Any molecular entity consisting of more than one atom.
id: CHEBI:36357
has_related_synonym: polyatomic entities
imported from: dron.owl

phosphorus oxoacids and derivatives
type: Class
subclass of: phosphorus molecular entity
id: CHEBI:36360
imported from: dron.owl

pseudoketone
type: Class
subclass of: carbonyl compound
id: CHEBI:36585
has_exact_synonym: pseudoketone
has_exact_synonym: pseudoketones
has_related_synonym: pseudoketones
imported from: dron.owl

carbonyl compound
type: Class
subclass of: organic oxo compound
subclass of: organooxygen compound
definition: Any compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives.
id: CHEBI:36586
has_exact_synonym: carbonyl compounds
imported from: dron.owl

organic oxo compound
type: Class
subclass of: organic molecular entity
id: CHEBI:36587
definition: Organic compounds containing an oxygen atom, =O, doubly bonded to carbon or another element.
has_related_synonym: organic oxo compounds
has_exact_synonym: oxo compounds
imported from: dron.owl

cyclic pseudoketone
type: Class
subclass of: pseudoketone
definition: A cyclic compound in which a carbonyl group in a ring is bonded to one or two skeletal heteroatoms.
id: CHEBI:36588
has_related_synonym: cyclic pseudoketones
imported from: dron.owl

acyclic pseudoketone
type: Class
subclass of: pseudoketone
id: CHEBI:36589
definition: Compounds in which an acyclic carbonyl group is bonded to one or two acyclic skeletal heteroatoms, except nitrogen, halogen, or halogenoid atoms, or to a heteroatom of a ring or ring system.
has_exact_synonym: acyclic pseudoketone
has_exact_synonym: acyclic pseudoketones
has_related_synonym: acyclic pseudoketones
imported from: dron.owl

organochlorine compound
type: Class
subclass of: chlorine molecular entity
subclass of: organohalogen compound
definition: An organochlorine compound is a compound containing at least one carbon-chlorine bond.
id: CHEBI:36683
has_related_synonym: chloroorganic compounds
has_related_synonym: chlororganische Verbindungen
has_exact_synonym: organochlorine compound
has_related_synonym: organochlorine compounds
imported from: dron.owl

organohalogen compound
type: Class
subclass of: heteroorganic entity
subclass of: halide
definition: A compound containing at least one carbon-halogen bond.
id: CHEBI:36684
has_related_synonym: organohalogen compounds
imported from: dron.owl

heterotricyclic compound
type: Class
subclass of: heteropolycyclic compound
id: CHEBI:36688
has_exact_synonym: heterotricyclic compound
has_related_synonym: heterotricyclic compounds
has_exact_synonym: heterotricyclic compounds
imported from: dron.owl

corticosteroid hormone
type: Class
subclass of: steroid hormone
subclass of: corticosteroid
definition: Any of a class of steroid hormones that are produced in the adrenal cortex.
id: CHEBI:36699
has_related_synonym: adrenal cortex hormones
has_related_synonym: corticosteroid hormones
imported from: dron.owl

aminoquinoline
type: Class
subclass of: quinolines
id: CHEBI:36709
has_exact_synonym: aminoquinoline
has_related_synonym: aminoquinolines
imported from: dron.owl

carbobicyclic compound
type: Class
subclass of: bicyclic compound
subclass of: carbopolycyclic compound
definition: A bicyclic compound in which all the ring atoms are carbon.
id: CHEBI:36785
has_related_synonym: carbobicyclic compounds
imported from: dron.owl

tricyclic antidepressant
type: Class
subclass of: organic tricyclic compound
id: CHEBI:36809
has_related_synonym: antidepresivo triciclico
has_related_synonym: antidepresivos triciclicos
has_related_synonym: tricyclic antidepressant drugs
has_related_synonym: tricyclic antidepressants
has_related_synonym: tricyclic antidepressive agents
imported from: dron.owl

5-methoxyvalerophenone O-(2-aminoethyl)oxime
type: Class
subclass of: oxime O-ether
id: CHEBI:36815
imported from: dron.owl

oxime O-ether
type: Class
subclass of: ether
id: CHEBI:36816
has_related_synonym: CNOR3
definition: O-organyl oximes R2C=NOR' (R' =/= H).
has_related_synonym: O-substituted oximes
has_related_synonym: [*]O\N=C(/[*])[*]
has_exact_synonym: oxime O-ether
has_related_synonym: oxime O-ethers
has_exact_synonym: oxime O-ethers
imported from: dron.owl

ring assembly
type: Class
subclass of: cyclic compound
id: CHEBI:36820
definition: Two or more cyclic systems (single rings or fused systems) which are directly joined to each other by double or single bonds are named ring assemblies when the number of such direct ring junctions is one less than the number of cyclic systems involved.
has_exact_synonym: ring assemblies
has_exact_synonym: ring assembly
imported from: dron.owl

17-hydroxy steroid
type: Class
subclass of: hydroxy steroid
has_related_synonym: 17-hydroxy steroids
id: CHEBI:36838
imported from: dron.owl

11-hydroxy steroid
type: Class
subclass of: hydroxy steroid
has_related_synonym: 11-hydroxy steroids
id: CHEBI:36841
imported from: dron.owl

20-oxo steroid
type: Class
subclass of: oxo steroid
has_related_synonym: 20-oxo steroids
id: CHEBI:36885
imported from: dron.owl

organochalcogen compound
type: Class
subclass of: heteroorganic entity
subclass of: chalcogen molecular entity
definition: An organochalcogen compound is a compound containing at least one carbon-chalcogen bond.
id: CHEBI:36962
has_exact_synonym: organochalcogen compound
has_related_synonym: organochalcogen compounds
imported from: dron.owl

organooxygen compound
type: Class
subclass of: oxygen molecular entity
subclass of: organochalcogen compound
definition: An organochalcogen compound containing at least one carbon-oxygen bond.
id: CHEBI:36963
database_cross_reference: CiteXplore:17586126
has_exact_synonym: organooxygen compound
has_related_synonym: organooxygen compounds
imported from: dron.owl

organoiodine compound
type: Class
subclass of: iodine molecular entity
subclass of: organohalogen compound
definition: An organoiodine compound is a compound containing at least one carbon-iodine bond.
id: CHEBI:37142
has_exact_synonym: organoiodine compound
has_related_synonym: organoiodine compounds
imported from: dron.owl

organofluorine compound
type: Class
subclass of: fluorine molecular entity
subclass of: organohalogen compound
definition: An organofluorine compound is a compound containing at least one carbon-fluorine bond.
id: CHEBI:37143
has_related_synonym: fluoroorganic compound
has_related_synonym: fluoroorganic compounds
has_related_synonym: fluoroorganics
has_related_synonym: fluororganische Verbindungen
has_exact_synonym: organofluorine compound
has_related_synonym: organofluorine compounds
imported from: dron.owl

hydroxyanthraquinones
type: Class
subclass of: anthraquinone
definition: An anthraquinone substituted with one or more hydroxy groups.
has_alternative_id: CHEBI:13829
has_alternative_id: CHEBI:24672
id: CHEBI:37485
has_related_synonym: an hydroxyanthraquinone
imported from: dron.owl

azo compound
type: Class
subclass of: nitrogen molecular entity
id: CHEBI:37533
definition: Derivatives of diazene with the general structure R-N=N-R'.
has_related_synonym: azo compounds
has_exact_synonym: azo compounds
imported from: dron.owl

heteroatomic molecular entity
type: Class
subclass of: polyatomic entity
definition: A molecular entity consisting of two or more chemical elements.
id: CHEBI:37577
has_related_synonym: chemical compound
has_related_synonym: heteroatomic molecular entities
imported from: dron.owl

halide
type: Class
subclass of: halogen molecular entity
subclass of: heteroatomic molecular entity
id: CHEBI:37578
imported from: dron.owl

nitrogen mustard
type: Class
subclass of: organonitrogen compound
id: CHEBI:37598
definition: Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-C2H2-C2H2)2NR.
has_related_synonym: nitrogen mustards
has_exact_synonym: nitrogen mustards
imported from: dron.owl

carboxamide
type: Class
subclass of: primary amide
definition: An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the -C(=O)NH2 group including its carbon atom.
has_alternative_id: CHEBI:35354
has_alternative_id: CHEBI:35355
id: CHEBI:37622
has_related_synonym: CNOR3
has_related_synonym: [*]C(=O)N([*])[*]
has_exact_synonym: carboxamides
has_related_synonym: carboxamides
has_related_synonym: primary carboxamide
imported from: dron.owl

clopidogrel
type: Class
subclass of: organochlorine compound
subclass of: thienopyridine
has_related_synonym: (+)-Clopidogrel
has_RxCUI: 32968
definition: A thienopyridine that has formula C16H16ClNO2S.
database_cross_reference: Beilstein:8151914
has_related_synonym: C16H16ClNO2S
id: CHEBI:37941
has_related_synonym: COC(=O)[C@@H](N1CCc2sccc2C1)c1ccccc1Cl
database_cross_reference: ChemIDplus:113665-84-2
database_cross_reference: DrugBank:DB00758
has_related_synonym: InChI=1S/C16H16ClNO2S/c1-20-16(19)15(12-4-2-3-5-13(12)17)18-8-6-14-11(10-18)7-9-21-14/h2-5,7,9,15H,6,8,10H2,1H3/t15-/m0/s1
has_related_synonym: InChIKey=GKTWGGQPFAXNFI-HNNXBMFYSA-N
database_cross_reference: Patent:EP281459
database_cross_reference: Patent:EP99802
database_cross_reference: Patent:US4529596
database_cross_reference: Patent:US4847265
database_cross_reference: Wikipedia:Clopidogrel
has_related_synonym: clopidogrel
has_related_synonym: clopidogrelum
has_exact_synonym: methyl (2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate
imported from: dron.owl

thienopyridine
type: Class
subclass of: organic heterobicyclic compound
subclass of: organonitrogen heterocyclic compound
subclass of: organosulfur heterocyclic compound
id: CHEBI:37942
has_related_synonym: thienopyridines
imported from: dron.owl

benzothiazoles
type: Class
subclass of: organic heterobicyclic compound
subclass of: organonitrogen heterocyclic compound
subclass of: organosulfur heterocyclic compound
id: CHEBI:37947
imported from: dron.owl

carbotricyclic compound
type: Class
subclass of: carbopolycyclic compound
subclass of: organic tricyclic compound
id: CHEBI:38032
has_related_synonym: carbotricyclic compounds
imported from: dron.owl

organonitrogen heterocyclic compound
type: Class
subclass of: organic heterocyclic compound
subclass of: organonitrogen compound
definition: Any organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms.
id: CHEBI:38101
has_related_synonym: heterocyclic organonitrogen compounds
has_related_synonym: organonitrogen heterocyclic compounds
imported from: dron.owl

oxacycle
type: Class
subclass of: organic heterocyclic compound
subclass of: organooxygen compound
definition: Any organic heterocyclic compound containing at least one ring oxygen atom.
id: CHEBI:38104
database_cross_reference: CiteXplore:17134300
has_related_synonym: heterocyclic organooxygen compounds
has_related_synonym: organooxygen heterocyclic compounds
has_related_synonym: oxacycles
imported from: dron.owl

organosulfur heterocyclic compound
type: Class
subclass of: organic heterocyclic compound
subclass of: organosulfur compound
id: CHEBI:38106
has_related_synonym: heterocyclic organosulfur compounds
has_related_synonym: organosulfur heterocyclic compounds
imported from: dron.owl

organic heteropentacyclic compound
type: Class
subclass of: organic heteropolycyclic compound
id: CHEBI:38164
has_related_synonym: organic heteropentacyclic compounds
imported from: dron.owl

organic heteropolycyclic compound
type: Class
subclass of: organic heterocyclic compound
subclass of: heteropolycyclic compound
has_alternative_id: CHEBI:25429
has_alternative_id: CHEBI:38075
id: CHEBI:38166
has_related_synonym: organic heteropolycyclic compounds
imported from: dron.owl

monocyclic heteroarene
type: Class
subclass of: heteroarene
id: CHEBI:38179
has_related_synonym: monocyclic heteroarenes
imported from: dron.owl

polycyclic heteroarene
type: Class
subclass of: heteroarene
id: CHEBI:38180
has_related_synonym: polycyclic heteroarenes
imported from: dron.owl

imidazolidines
type: Class
subclass of: organonitrogen heterocyclic compound
subclass of: diazolidine
id: CHEBI:38261
imported from: dron.owl

azabicycloalkane
type: Class
subclass of: organic heterobicyclic compound
subclass of: organonitrogen heterocyclic compound
id: CHEBI:38295
has_related_synonym: azabicycloalkanes
imported from: dron.owl

cyclopentapyrrole
type: Class
subclass of: organic heterobicyclic compound
subclass of: organonitrogen heterocyclic compound
id: CHEBI:38296
has_related_synonym: cyclopentapyrroles
imported from: dron.owl

benzodioxoles
type: Class
subclass of: organic heterobicyclic compound
subclass of: oxacycle
id: CHEBI:38298
imported from: dron.owl

diazolidine
type: Class
subclass of: organic heteromonocyclic compound
subclass of: organonitrogen heterocyclic compound
id: CHEBI:38304
has_related_synonym: diazolidines
imported from: dron.owl

cephem
type: Class
subclass of: organic heterobicyclic compound
subclass of: beta-lactam antibiotic
subclass of: beta-lactam
subclass of: organonitrogen heterocyclic compound
subclass of: organosulfur heterocyclic compound
id: CHEBI:38311
has_related_synonym: cephems
imported from: dron.owl

diazines
type: Class
subclass of: organic heteromonocyclic compound
subclass of: organonitrogen heterocyclic compound
definition: Any organic heterocyclic compound containing a benzene ring in which two of the C-H fragments have been replaced by isolobal nitrogens (the diazine parent structure).
id: CHEBI:38313
imported from: dron.owl

pyrimidone
type: Class
subclass of: pyrimidines
id: CHEBI:38337
has_related_synonym: pyrimidones
imported from: dron.owl

1,3-thiazole
type: Class
subclass of: thiazoles
has_related_synonym: 1,3-thiazoles
has_alternative_id: CHEBI:26949
has_alternative_id: CHEBI:38417
id: CHEBI:38418
imported from: dron.owl

phenethylamine alkaloid
type: Class
subclass of: alkaloid
id: CHEBI:38605
has_related_synonym: phenethylamine alkaloids
imported from: dron.owl

pyrazolopyrimidine
type: Class
subclass of: organic heterobicyclic compound
subclass of: organonitrogen heterocyclic compound
id: CHEBI:38669
has_related_synonym: pyrazolopyrimidines
imported from: dron.owl

Aurothiomalate
type: Class
label: aurothiomalic acid
subclass of: gold coordination entity
has_related_synonym: (1,2-dicarboxyethylthio)gold
has_exact_synonym: 1,2-dicarboxyethanethiolatogold(I)
has_exact_synonym: 1,2-dicarboxyethylsulfanylgold
has_RxCUI: 42547
definition: A gold coordination entity that has formula C4H5AuO4S.
database_cross_reference: Beilstein:4030297
has_related_synonym: C4H5AuO4S
id: CHEBI:38722
database_cross_reference: ChemIDplus:4846-27-9
database_cross_reference: Gmelin:1043252
database_cross_reference: Gmelin:1288314
has_related_synonym: InChI=1S/C4H6O4S.Au/c5-3(6)1-2(9)4(7)8;/h2,9H,1H2,(H,5,6)(H,7,8);/q;+1/p-1
has_related_synonym: InChIKey=XJHSMFDIQHVMCY-UHFFFAOYSA-M
has_related_synonym: OC(=O)CC(S[Au])C(O)=O
has_related_synonym: aurothiomalate
has_exact_synonym: gold(1+) 1,2-dicarboxyethanethiolate
has_related_synonym: mercaptobutanedioic acid, monogold(1+) salt
imported from: dron.owl

1-benzofurans
type: Class
subclass of: benzofurans
id: CHEBI:38830
imported from: dron.owl

indole alkaloid
type: Class
subclass of: alkaloid
subclass of: indoles
definition: An alkaloid containing an indole skeleton.
has_alternative_id: CHEBI:24795
id: CHEBI:38958
has_alternative_id: CHEBI:5901
has_exact_synonym: Indole alkaloid
database_cross_reference: KEGG COMPOUND:C06073
has_related_synonym: indole alkaloids
imported from: dron.owl

dioxolane
type: Class
subclass of: organic heteromonocyclic compound
subclass of: oxacycle
id: CHEBI:39430
has_related_synonym: dioxolanes
imported from: dron.owl

pyrimidines
type: Class
subclass of: diazines
definition: Any compound having a pyrimidine as part of its structure.
has_alternative_id: CHEBI:13681
has_alternative_id: CHEBI:26448
id: CHEBI:39447
imported from: dron.owl

atorvastatin
type: Class
subclass of: pyrroles
subclass of: dihydroxy monocarboxylic acid
has_exact_synonym: (3R,5R)-7-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-4-phenyl-2-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid
has_related_synonym: (R-(R*,R*))-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-1H-pyrrole-1-heptanoic acid
has_related_synonym: 7-[2-(4-FLUORO-PHENYL)-5-ISOPROPYL-3-PHENYL-4-PHENYLCARBAMOYL-PYRROL-1-YL]-3,5-DIHYDROXY-HEPTANOIC ACID
has_RxCUI: 83367
definition: A dihydroxy monocarboxylic acid that has formula C33H35FN2O5.
has_related_synonym: Atorlip
has_exact_synonym: Atorvastatin
database_cross_reference: Beilstein:8373630
has_related_synonym: C33H35FN2O5
has_alternative_id: CHEBI:2910
has_alternative_id: CHEBI:39538
id: CHEBI:39548
database_cross_reference: ChemIDplus:134523-00-5
database_cross_reference: DrugBank:DB01076
has_related_synonym: InChI=1S/C33H35FN2O5/c1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40/h3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40)/t26-,27-/m1/s1
has_related_synonym: InChIKey=XUKUURHRXDUEBC-KAYWLYCHSA-N
database_cross_reference: KEGG COMPOUND:134523-00-5
database_cross_reference: KEGG COMPOUND:C06834
database_cross_reference: KEGG DRUG:D07474
database_cross_reference: PDBeChem:117
database_cross_reference: Patent:EP409281
database_cross_reference: Patent:US5273995
database_cross_reference: Wikipedia:Atorvastatin
has_related_synonym: atorvastatin
has_related_synonym: atorvastatina
has_related_synonym: atorvastatine
has_related_synonym: atorvastatinum
imported from: dron.owl

cyclic ketone
type: Class
subclass of: ketone
id: CHEBI:3992
has_exact_synonym: Cyclic ketone
database_cross_reference: KEGG COMPOUND:C02019
has_exact_synonym: cyclic ketones
imported from: dron.owl

cyclobenzaprine
type: Class
subclass of: tricyclic antidepressant
has_related_synonym: (3-Dibenzo[a,d]cyclohepten-5-ylidene-propyl)-dimethyl-amine
has_RxCUI: 21949
has_exact_synonym: 3-(5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine
has_exact_synonym: 3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethylpropan-1-amine
definition: 5-Methylidene-5H-dibenzo[a,d]cycloheptene in which one of the hydrogens of the methylidene group is substituted by a 2-(dimethylamino)ethyl group. A centrally acting skeletal muscle relaxant, it is used as its hydrochloride salt in the symptomatic treatment of painful muscle spasm.
database_cross_reference: Beilstein:2126383
has_related_synonym: C20H21N
has_alternative_id: CHEBI:128119
id: CHEBI:3996
has_related_synonym: CN(C)CCC=C1c2ccccc2C=Cc2ccccc12
database_cross_reference: ChEMBL:128119
database_cross_reference: ChEMBL:17725338
database_cross_reference: ChEMBL:18027916
has_exact_synonym: Cyclobenzaprine
database_cross_reference: DrugBank:DB00924
has_related_synonym: InChI=1S/C20H21N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-14H,7,15H2,1-2H3
has_related_synonym: InChIKey=JURKNVYFZMSNLP-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:303-53-7
database_cross_reference: KEGG COMPOUND:C06931
database_cross_reference: KEGG DRUG:D07758
has_related_synonym: N,N-dimethyl-5H-dibenzo(a,d)cycloheptene-Delta(5,gamma)-propylamine
database_cross_reference: NIST Chemistry WebBook:303-53-7
database_cross_reference: Patent:GB858187
database_cross_reference: Wikipedia:Cyclobenzaprine
has_related_synonym: ciclobenzaprina
has_related_synonym: cyclobenzaprine
has_related_synonym: cyclobenzaprinum
imported from: dron.owl

Allopurinol
type: Class
label: allopurinol
subclass of: organic heterobicyclic compound
has_related_synonym: 1,5-Dihydro-4H-pyrazolo(3,4-d)pyrimidin-4-one
has_related_synonym: 1,5-Dihydro-4H-pyrazolo(3,4-d)pyrimidine-4-one
has_related_synonym: 1H-Pyrazolo(3,4-d)pyrimidin-4-ol
has_exact_synonym: 1H-pyrazolo[3,4-d]pyrimidin-4-ol
has_related_synonym: 4'-Hydroxypyrazolol(3,4-d)pyrimidine
has_related_synonym: 4-HPP
has_related_synonym: 4-Hydroxy-1H-pyrazolo(3,4-d)pyrimidine
has_related_synonym: 4-Hydroxy-3,4-pyrazolopyrimidine
has_related_synonym: 4-Hydroxypyrazolo(3,4-d)pyrimidine
has_related_synonym: 4-Hydroxypyrazolopyrimidine
has_related_synonym: 4-Hydroxypyrazolyl(3,4-d)pyrimidine
has_related_synonym: 4H-Pyrazolo(3,4-d)pyrimidin-4-one
has_RxCUI: 519
definition: A bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring.
has_related_synonym: AL-100
has_exact_synonym: Allopurinol
has_related_synonym: Allopurinolum
has_related_synonym: Alopurinol
database_cross_reference: Beilstein:608611
has_related_synonym: C5H4N4O
has_alternative_id: CHEBI:2601
has_alternative_id: CHEBI:40276
id: CHEBI:40279
database_cross_reference: ChemIDplus:315-30-0
database_cross_reference: CiteXplore:7602118
database_cross_reference: DrugBank:DB00437
has_related_synonym: InChI=1S/C5H4N4O/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10)
has_related_synonym: InChIKey=OFCNXPDARWKPPY-UHFFFAOYSA-N
database_cross_reference: KEGG DRUG:315-30-0
database_cross_reference: KEGG DRUG:D00224
database_cross_reference: NIST Chemistry WebBook:315-30-0
has_related_synonym: Oc1ncnc2[nH]ncc12
database_cross_reference: Wikipedia:Allopurinol
has_related_synonym: Zyloprim (TN)
imported from: dron.owl

Lovastatin
type: Class
label: lovastatin
subclass of: delta-lactone
subclass of: fatty acid ester
has_related_synonym: (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate
has_exact_synonym: (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
has_related_synonym: 2beta,6alpha-dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactone
has_RxCUI: 6472
has_related_synonym: 6alpha-methylcompactin
definition: A delta-lactone that has formula C24H36O5.
has_related_synonym: C24H36O5
has_alternative_id: CHEBI:40299
id: CHEBI:40303
has_alternative_id: CHEBI:6544
database_cross_reference: ChemIDplus:3631989
database_cross_reference: ChemIDplus:75330-75-5
has_related_synonym: InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1
has_related_synonym: InChIKey=PCZOHLXUXFIOCF-BXMDZJJMSA-N
database_cross_reference: KEGG COMPOUND:C07074
database_cross_reference: KEGG DRUG:75330-75-5
database_cross_reference: KEGG DRUG:D00359
has_exact_synonym: LOVASTATIN
has_exact_synonym: Lovastatin
has_related_synonym: MK-803
has_related_synonym: ML-530B
has_related_synonym: Mevacor
has_related_synonym: Mevinolin
database_cross_reference: PDBeChem:803
database_cross_reference: Wikipedia:Lovastatin
imported from: dron.owl

Cyclosporine
type: Class
label: cyclosporin A
subclass of: homodetic cyclic peptide
has_related_synonym: (R-[R*,R*-(E)])-Cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-alpha-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl)
has_related_synonym: 1,11-cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(E)-(2S,3R,4R)-2-amino-3-hydroxy-N,4-dimethyloct-6-enoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucine]
has_exact_synonym: 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
has_related_synonym: 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
has_RxCUI: 3008
definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
has_related_synonym: Antibiotic S 7481F1
database_cross_reference: Beilstein:3647785
has_related_synonym: C62H111N11O12
id: CHEBI:4031
has_alternative_id: CHEBI:63586
database_cross_reference: ChemIDplus:59865-13-3
has_related_synonym: Ciclosporin
database_cross_reference: CiteXplore:11058832
database_cross_reference: CiteXplore:11069928
database_cross_reference: CiteXplore:11079273
database_cross_reference: CiteXplore:11080188
database_cross_reference: CiteXplore:11238591
database_cross_reference: CiteXplore:11256490
database_cross_reference: CiteXplore:11278005
database_cross_reference: CiteXplore:11315347
database_cross_reference: CiteXplore:11370709
database_cross_reference: CiteXplore:11406057
database_cross_reference: CiteXplore:11426833
database_cross_reference: CiteXplore:11442023
database_cross_reference: CiteXplore:11481617
database_cross_reference: CiteXplore:11493684
database_cross_reference: CiteXplore:11529914
database_cross_reference: CiteXplore:11557554
database_cross_reference: CiteXplore:11564166
database_cross_reference: CiteXplore:11676831
database_cross_reference: CiteXplore:11870366
database_cross_reference: CiteXplore:12021257
database_cross_reference: CiteXplore:12050171
database_cross_reference: CiteXplore:12603598
database_cross_reference: CiteXplore:12761440
database_cross_reference: CiteXplore:12929192
database_cross_reference: CiteXplore:12950728
database_cross_reference: CiteXplore:14521916
database_cross_reference: CiteXplore:14621732
database_cross_reference: CiteXplore:14638917
database_cross_reference: CiteXplore:14672695
database_cross_reference: CiteXplore:14682659
database_cross_reference: CiteXplore:14743390
database_cross_reference: CiteXplore:15030555
database_cross_reference: CiteXplore:15175101
database_cross_reference: CiteXplore:15210365
database_cross_reference: CiteXplore:15306697
database_cross_reference: CiteXplore:15383526
database_cross_reference: CiteXplore:15541012
database_cross_reference: CiteXplore:15613074
database_cross_reference: CiteXplore:15626898
database_cross_reference: CiteXplore:15657176
database_cross_reference: CiteXplore:1566062
database_cross_reference: CiteXplore:15711594
database_cross_reference: CiteXplore:15811524
database_cross_reference: CiteXplore:15962181
database_cross_reference: CiteXplore:16372476
database_cross_reference: CiteXplore:16404634
database_cross_reference: CiteXplore:16724420
database_cross_reference: CiteXplore:16801218
database_cross_reference: CiteXplore:16898534
database_cross_reference: CiteXplore:17032751
database_cross_reference: CiteXplore:17083576
database_cross_reference: CiteXplore:17117422
database_cross_reference: CiteXplore:17192032
database_cross_reference: CiteXplore:17220244
database_cross_reference: CiteXplore:17229932
database_cross_reference: CiteXplore:17265451
database_cross_reference: CiteXplore:17446460
database_cross_reference: CiteXplore:17603747
database_cross_reference: CiteXplore:18076075
database_cross_reference: CiteXplore:18171316
database_cross_reference: CiteXplore:18191430
database_cross_reference: CiteXplore:18217899
database_cross_reference: CiteXplore:18259730

Tamoxifen
type: Class
label: tamoxifen
subclass of: tertiary amino compound
has_related_synonym: (Z)-2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine
has_related_synonym: (Z)-2-(para-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine
has_related_synonym: 1-p-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
has_related_synonym: 1-para-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
has_RxCUI: 10324
has_exact_synonym: 2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine
definition: A tertiary amino compound that has formula C26H29NO.
has_related_synonym: Apo-Tamox
database_cross_reference: Beilstein:2062020
has_related_synonym: C26H29NO
has_related_synonym: CC\C(c1ccccc1)=C(/c1ccccc1)c1ccc(OCCN(C)C)cc1
has_alternative_id: CHEBI:41767
id: CHEBI:41774
has_alternative_id: CHEBI:9396
database_cross_reference: ChemIDplus:10540-29-1
has_related_synonym: Crisafeno
has_related_synonym: Diemon
database_cross_reference: DrugBank:DB00675
has_related_synonym: InChI=1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3/b26-25-
has_related_synonym: InChIKey=NKANXQFJJICGDU-QPLCGJKRSA-N
database_cross_reference: KEGG COMPOUND:10540-29-1
database_cross_reference: KEGG COMPOUND:C07108
database_cross_reference: Patent:BE637389
database_cross_reference: Patent:BE678807
database_cross_reference: Patent:US4536516
has_exact_synonym: Tamoxifen
database_cross_reference: Wikipedia:Tamoxifen
has_related_synonym: tamoxifen
has_related_synonym: tamoxifene
has_related_synonym: tamoxifeno
has_related_synonym: tamoxifenum
has_related_synonym: trans-Tamoxifen
imported from: dron.owl

Dexamethasone
type: Class
label: dexamethasone
subclass of: glucocorticoid
subclass of: 17alpha-hydroxy steroid
subclass of: 21-hydroxy steroid
subclass of: 11beta-hydroxy steroid
subclass of: 20-oxo steroid
subclass of: 3-oxo steroid
subclass of: fluorinated steroid
has_related_synonym: 1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone
has_related_synonym: 16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol
has_RxCUI: 3264
has_exact_synonym: 9-fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione
has_related_synonym: 9alpha-Fluoro-16alpha-methylprednisolone
definition: A fluorinated steroid that has formula C22H29FO5.
database_cross_reference: Beilstein:2066652
has_related_synonym: C22H29FO5
has_alternative_id: CHEBI:41873
id: CHEBI:41879
has_alternative_id: CHEBI:4461
database_cross_reference: ChemIDplus:50-02-2
has_related_synonym: Decadron
has_exact_synonym: Dexamethasone
database_cross_reference: DrugBank:DB01234
has_related_synonym: InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
has_related_synonym: InChIKey=UREBDLICKHMUKA-CXSFZGCWSA-N
database_cross_reference: KEGG DRUG:D00292
database_cross_reference: Patent:DE1113690
database_cross_reference: Patent:GB869511
database_cross_reference: Patent:US3007923
database_cross_reference: Wikipedia:Dexamethasone
has_related_synonym: dexametasona
has_related_synonym: dexamethasone
has_related_synonym: dexamethasonum
imported from: dron.owl

Dapsone
type: Class
label: dapsone
subclass of: sulfone
has_related_synonym: 1,1'-sulfonylbis(4-aminobenzene)
has_RxCUI: 3108
has_related_synonym: 4,4'-Sulfonylbisbenzenamine
has_related_synonym: 4,4'-dapsone
has_related_synonym: 4,4'-diaminodiphenyl sulfone
has_related_synonym: 4,4'-sulfonylbisaniline
has_exact_synonym: 4,4'-sulfonyldianiline
has_related_synonym: 4-(4-amino-benzenesulfonyl)-phenylamine
has_related_synonym: 4-(4-aminophenylsulfonyl)aniline
has_related_synonym: 4-(4-aminophenylsulfonyl)benzenamine
has_related_synonym: 4-aminophenyl sulfone
database_cross_reference: Beilstein:788055
has_related_synonym: Bis(p-aminophenyl) sulfone
has_related_synonym: C12H12N2O2S
has_alternative_id: CHEBI:226356
id: CHEBI:4325
database_cross_reference: ChEMBL:226356
database_cross_reference: ChemIDplus:80-08-0
has_related_synonym: DADPS
has_exact_synonym: DAPSONE
has_related_synonym: DDS
has_related_synonym: DIAPHENYLSULFONE
has_exact_synonym: Dapsone
has_related_synonym: Diaphenylsulfone
definition: Diphenylsulfone in which the hydrogen atom at the 4 position of each of the phenyl groups is substituted by an amino group. It is active against a wide range of bacteria, but is mainly employed for its actions against Mycobacterium leprae, being used as part of multidrug regimens in the treatment of all forms of leprosy.
database_cross_reference: DrugBank:DB00250
has_related_synonym: InChI=1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2
has_related_synonym: InChIKey=MQJKPEGWNLWLTK-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:80-08-0
database_cross_reference: KEGG COMPOUND:C07666
database_cross_reference: KEGG DRUG:D00592
database_cross_reference: NIST Chemistry WebBook:80-08-0
has_related_synonym: Nc1ccc(cc1)S(=O)(=O)c1ccc(N)cc1
database_cross_reference: Patent:FR829926
database_cross_reference: Wikipedia:Dapsone
has_related_synonym: bis(4-aminophenyl)sulfone
has_related_synonym: dapsona
has_related_synonym: dapsone
has_related_synonym: dapsonum
has_related_synonym: p,p'-diaminodiphenyl sulfone
has_related_synonym: p,p-sulphonylbisbenzamine
has_related_synonym: p,p-sulphonylbisbenzenamine
has_related_synonym: p-aminophenyl sulfone
imported from: dron.owl

Deferoxamine
type: Class
label: desferrioxamine B
subclass of: acyclic desferrioxamine
has_RxCUI: 3131
definition: An acyclic desferrioxamine that has formula C25H48N6O8.
database_cross_reference: Beilstein:2514118
has_related_synonym: C25H48N6O8
id: CHEBI:4356
database_cross_reference: ChemIDplus:70-51-9
has_related_synonym: DFO
has_related_synonym: Deferoxamin
has_related_synonym: Deferrioxamine
has_related_synonym: Desferrioxamine
database_cross_reference: DrugBank:DB00746
has_related_synonym: InChI=1S/C25H48N6O8/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34)
has_related_synonym: InChIKey=UBQYURCVBFRUQT-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:C06940
database_cross_reference: KEGG DRUG:D03670
has_exact_synonym: N'-{5-[acetyl(hydroxy)amino]pentyl}-N-(5-{4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanamido}pentyl)-N-hydroxybutanediamide
database_cross_reference: Patent:BE609053
database_cross_reference: Wikipedia:Deferoxamine
has_related_synonym: deferoxamina
has_related_synonym: deferoxamine
has_related_synonym: deferoxaminum
has_related_synonym: deferrioxamine B
imported from: dron.owl

Lisinopril
type: Class
label: lisinopril
subclass of: dipeptide
has_related_synonym: (S)-1-(N(2)-(1-carboxy-3-phenylpropyl)-L-lysyl)-L-proline
has_RxCUI: 29046
definition: A dipeptide that has formula C21H31N3O5.
database_cross_reference: Beilstein:4276619
has_related_synonym: C21H31N3O5
has_alternative_id: CHEBI:43750
id: CHEBI:43755
database_cross_reference: ChemIDplus:76547-98-3
has_related_synonym: InChI=1S/C21H31N3O5/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15/h1-3,7-8,16-18,23H,4-6,9-14,22H2,(H,26,27)(H,28,29)/t16-,17-,18-/m0/s1
has_related_synonym: InChIKey=RLAWWYSOJDYHDC-BZSNNMDCSA-N
has_exact_synonym: N(2)-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline
database_cross_reference: PDBeChem:LPR
database_cross_reference: Wikipedia:Lisinopril
has_related_synonym: [N2-[(S)-1-CARBOXY-3-PHENYLPROPYL]-L-LYSYL-L-PROLINE
has_related_synonym: lisinopril anhydrous
imported from: dron.owl

Methotrexate
type: Class
label: methotrexate
subclass of: pteridines
subclass of: monocarboxylic acid amide
subclass of: dicarboxylic acid
has_related_synonym: 4-amino-10-methylfolic acid
has_related_synonym: 4-amino-N(10)-methylpteroylglutamic acid
has_RxCUI: 6851
definition: A pteridine that has formula C20H22N8O5.
database_cross_reference: Beilstein:70669
has_related_synonym: C20H22N8O5
has_alternative_id: CHEBI:44183
id: CHEBI:44185
has_alternative_id: CHEBI:6837
database_cross_reference: ChemIDplus:59-05-2
database_cross_reference: DrugBank:DB00563
has_related_synonym: Emtexate
has_related_synonym: InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1
has_related_synonym: InChIKey=FBOZXECLQNJBKD-ZDUSSCGKSA-N
database_cross_reference: KEGG COMPOUND:59-05-2
database_cross_reference: KEGG COMPOUND:C01937
database_cross_reference: KEGG DRUG:D00142
has_related_synonym: Ledertrexate
has_exact_synonym: METHOTREXATE
has_related_synonym: MTX
has_exact_synonym: Methotrexate
has_exact_synonym: N-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)-L-glutamic acid
has_related_synonym: N-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)carbonyl]-L-glutamic acid
has_related_synonym: N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
database_cross_reference: NIST Chemistry WebBook:59-05-2
database_cross_reference: PDBeChem:MTX
database_cross_reference: Patent:US2512572
has_related_synonym: Rheumatrex
has_related_synonym: Trexall
database_cross_reference: Wikipedia:Methotrexate
has_related_synonym: methotrexate
has_related_synonym: methotrexatum
has_related_synonym: metotrexato
imported from: dron.owl

hydroxyurea
type: Class
subclass of: ureas
has_RxCUI: 5552
definition: An urea that has formula CH4N2O2.
has_related_synonym: CH4N2O2
has_alternative_id: CHEBI:44420
id: CHEBI:44423
has_alternative_id: CHEBI:5816
database_cross_reference: ChemIDplus:127-07-1
database_cross_reference: ChemIDplus:1741548
database_cross_reference: Gmelin:130423
has_related_synonym: Hydroxycarbamid
has_related_synonym: Hydroxycarbamide
has_related_synonym: Hydroxyharnstoff
has_exact_synonym: Hydroxyurea
has_related_synonym: InChI=1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
has_related_synonym: InChIKey=VSNHCAURESNICA-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:127-07-1
database_cross_reference: KEGG COMPOUND:C07044
has_related_synonym: N-HYDROXYUREA
has_related_synonym: N-carbamoylhydroxylamine
has_exact_synonym: N-hydroxyurea
has_related_synonym: NC(=O)NO
database_cross_reference: PDBeChem:NHY
database_cross_reference: Wikipedia:Hydroxyurea
has_related_synonym: carbamohydroxamic acid
has_related_synonym: carbamohydroximic acid
has_related_synonym: carbamoyl oxime
has_related_synonym: carbamyl hydroxamate
has_related_synonym: hydrea
has_related_synonym: hydroxycarbamide
has_related_synonym: oxyurea
imported from: dron.owl

Propofol
type: Class
label: propofol
subclass of: phenols
has_related_synonym: 2,6-BIS(1-METHYLETHYL)PHENOL
has_related_synonym: 2,6-Diisopropylphenol
has_related_synonym: 2,6-bis(1-methylethyl)phenol
has_exact_synonym: 2,6-bis(propan-2-yl)phenol
has_RxCUI: 8782
definition: A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
has_related_synonym: C12H18O
has_related_synonym: CC(C)c1cccc(C(C)C)c1O
has_alternative_id: CHEBI:44914
id: CHEBI:44915
has_alternative_id: CHEBI:8495
database_cross_reference: ChemIDplus:1866484
database_cross_reference: ChemIDplus:2078-54-8
has_related_synonym: Diprivan
has_related_synonym: Disoprivan
has_related_synonym: Disoprofol
database_cross_reference: DrugBank:DB00818
has_related_synonym: InChI=1S/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H3
has_related_synonym: InChIKey=OLBCVFGFOZPWHH-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:2078-54-8
database_cross_reference: KEGG COMPOUND:C07523
database_cross_reference: KEGG DRUG:D00549
database_cross_reference: NIST Chemistry WebBook:2078-54-8
database_cross_reference: PDBeChem:PFL
has_exact_synonym: Propofol
has_related_synonym: Rapinovet
database_cross_reference: Wikipedia:Propofol
has_related_synonym: propofol
has_related_synonym: propofolum
imported from: dron.owl

Pentamidine
type: Class
label: pentamidine
subclass of: carboxamidine
subclass of: diether
has_related_synonym: 1,5-bis(4-amidinophenoxy)pentane
has_related_synonym: 4,4'-(1,5-pentanediylbis(oxy))bis-benzenecarboximidamide
has_related_synonym: 4,4'-(pentamethylenedioxy)dibenzamidine
has_related_synonym: 4,4'-Diamidinodiphenoxypentane
has_exact_synonym: 4,4'-[pentane-1,5-diylbis(oxy)]dibenzenecarboximidamide
has_RxCUI: 7994
definition: A diether compound consisting of pentane-1,5-diol with both hydroxyls bearing 4-amidinophenyl groups.
has_related_synonym: C19H24N4O2
has_alternative_id: CHEBI:45077
id: CHEBI:45081
has_alternative_id: CHEBI:7976
database_cross_reference: ChemIDplus:100-33-4
database_cross_reference: ChemIDplus:3159790
database_cross_reference: CiteXplore:11438428
database_cross_reference: CiteXplore:14603035
database_cross_reference: CiteXplore:15711592
database_cross_reference: CiteXplore:18971316
database_cross_reference: CiteXplore:19966562
database_cross_reference: CiteXplore:22046004
database_cross_reference: CiteXplore:22093811
database_cross_reference: CiteXplore:22200378
database_cross_reference: CiteXplore:22327112
database_cross_reference: DrugBank:DB00738
has_related_synonym: InChI=1S/C19H24N4O2/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23)
has_related_synonym: InChIKey=XDRYMKDFEDOLFX-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:100-33-4
database_cross_reference: KEGG COMPOUND:C07420
database_cross_reference: KEGG DRUG:D08333
has_related_synonym: NC(=N)c1ccc(OCCCCCOc2ccc(cc2)C(N)=N)cc1
database_cross_reference: PDBeChem:PNT
database_cross_reference: Patent:EP975608
database_cross_reference: Patent:GB507565
database_cross_reference: Patent:US2006235001
database_cross_reference: Patent:US2008167296
database_cross_reference: Patent:US2008214569
database_cross_reference: Patent:US2394003
database_cross_reference: Patent:US7115665
has_exact_synonym: Pentamidine
database_cross_reference: Reaxys:3159790
database_cross_reference: Wikipedia:Pentamidine
has_related_synonym: p,p'-(pentamethylenedioxy)dibenzamidine
has_related_synonym: pentamidine
imported from: dron.owl

Ritonavir
type: Class
label: ritonavir
subclass of: valine derivative
subclass of: 1,3-thiazole
has_RxCUI: 85762
id: CHEBI:45409
imported from: dron.owl

Paclitaxel
type: Class
label: paclitaxel
subclass of: taxane diterpenoid
subclass of: tetracyclic diterpenoid
has_related_synonym: (2aR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha R*,betaS*),11alpha,12alpha,12balpha))-beta-(Benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester
has_exact_synonym: 4alpha,10beta-bis(acetyloxy)-13alpha-[(2S,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyloxy]-1,7beta-dihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate
has_RxCUI: 56946
has_related_synonym: 5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
has_related_synonym: C47H51NO14
has_alternative_id: CHEBI:45862
id: CHEBI:45863
has_alternative_id: CHEBI:7887
database_cross_reference: ChemIDplus:33069-62-4
has_related_synonym: InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1
has_related_synonym: InChIKey=RCINICONZNJXQF-MZXODVADSA-N
database_cross_reference: KEGG COMPOUND:33069-62-4
database_cross_reference: KEGG COMPOUND:C07394
database_cross_reference: KEGG DRUG:D00491
database_cross_reference: PDBeChem:TA1
has_exact_synonym: Paclitaxel
has_related_synonym: TAXOL
has_related_synonym: Taxol A
database_cross_reference: Wikipedia:Paclitaxel
imported from: dron.owl

Fluconazole
type: Class
label: fluconazole
subclass of: tertiary alcohol
subclass of: triazoles
subclass of: organofluorine compound
has_related_synonym: 2,4-difluoro-alpha,alpha-bis(1H-1,2,4-triazol-1-ylmethyl)benzyl alcohol
has_related_synonym: 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL
has_exact_synonym: 2-(2,4-difluorophenyl)-1,3-bis-(1H-1,2,4-triazol-1-yl)propan-2-ol
has_RxCUI: 4450
definition: A triazole that has formula C13H12F2N6O.
database_cross_reference: Beilstein:4269710
has_related_synonym: Biozolene
has_related_synonym: C13H12F2N6O
has_alternative_id: CHEBI:46079
id: CHEBI:46081
has_alternative_id: CHEBI:5099
database_cross_reference: ChemIDplus:86386-73-4
has_related_synonym: Diflucan
has_related_synonym: Elazor
has_exact_synonym: Fluconazole
has_related_synonym: InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2
has_related_synonym: InChIKey=RFHAOTPXVQNOHP-UHFFFAOYSA-N
database_cross_reference: KEGG DRUG:D00322
has_related_synonym: OC(Cn1cncn1)(Cn1cncn1)c1ccc(F)cc1F
database_cross_reference: PDBeChem:TPF
has_related_synonym: Triflucan
database_cross_reference: Wikipedia:Fluconazole
imported from: dron.owl

vardenafil
type: Class
subclass of: N-alkylpiperazine
subclass of: imidazotriazine
subclass of: N-sulfonylpiperazine
has_related_synonym: 2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE
has_exact_synonym: 2-{2-ethoxy-5-[(4-ethylpiperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one
has_RxCUI: 306674
database_cross_reference: Beilstein:9967331
has_related_synonym: C23H32N6O4S
has_related_synonym: CCCc1nc(C)c2n1[nH]c(nc2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(CC)CC1
id: CHEBI:46295
database_cross_reference: ChemIDplus:224785-90-4
database_cross_reference: CiteXplore:19949666
database_cross_reference: CiteXplore:19959201
database_cross_reference: CiteXplore:20859794
database_cross_reference: CiteXplore:20925442
database_cross_reference: CiteXplore:21209618
database_cross_reference: CiteXplore:21235726
database_cross_reference: CiteXplore:21290241
database_cross_reference: CiteXplore:21427994
database_cross_reference: CiteXplore:21496853
database_cross_reference: CiteXplore:21548209
database_cross_reference: CiteXplore:21552528
database_cross_reference: CiteXplore:21771280
database_cross_reference: CiteXplore:21883954
database_cross_reference: CiteXplore:21943935
database_cross_reference: CiteXplore:21950284
database_cross_reference: DrugBank:DB00862
has_related_synonym: InChI=1S/C23H32N6O4S/c1-5-8-20-24-16(4)21-23(30)25-22(26-29(20)21)18-15-17(9-10-19(18)33-7-3)34(31,32)28-13-11-27(6-2)12-14-28/h9-10,15H,5-8,11-14H2,1-4H3,(H,25,26,30)
has_related_synonym: InChIKey=SECKRCOLJRRGGV-UHFFFAOYSA-N
database_cross_reference: KEGG DRUG:D08668
has_related_synonym: Levitra
database_cross_reference: PDBeChem:VDN
database_cross_reference: Reaxys:9967331
definition: The sulfonamide resulting from formal condensation of the sulfo group of 4-ethoxy-3-(5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one-2-yl)benzenesulfonic acid and the secondary amino group of 4-ethylpiperazine.
database_cross_reference: Wikipedia:Vardenafil
imported from: dron.owl

5-fluorouracil
type: Class
label: Fluorouracil
subclass of: organofluorine compound
has_RxCUI: 4492
has_related_synonym: 5-FU
has_related_synonym: 5-Fluoropyrimidine-2,4-dione
has_exact_synonym: 5-Fluorouracil
has_exact_synonym: 5-fluoropyrimidine-2,4(1H,3H)-dione
has_exact_synonym: 5-fluorouracil
definition: An organofluorine compound that has formula C4H3FN2O2.
database_cross_reference: Beilstein:127172
has_related_synonym: C4H3FN2O2
has_alternative_id: CHEBI:2054
has_alternative_id: CHEBI:46343
id: CHEBI:46345
database_cross_reference: ChemIDplus:51-21-8
has_related_synonym: Fc1c[nH]c(=O)[nH]c1=O
has_related_synonym: Fluorouracil
has_related_synonym: InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
has_related_synonym: InChIKey=GHASVSINZRGABV-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:51-21-8
database_cross_reference: KEGG COMPOUND:C07649
database_cross_reference: Wikipedia:Fluorouracil
imported from: dron.owl

Ganciclovir
type: Class
label: ganciclovir
subclass of: 2-aminopurines
subclass of: oxopurine
has_related_synonym: 2-(6-Amino-purin-9-ylmethoxy)-propane-1,3-diol
has_related_synonym: 2-Amino-9-(2-hydroxy-1-hydroxymethyl-ethoxymethyl)-1,9-dihydro-purin-6-one
has_related_synonym: 2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-1H-purin-6(9H)-one
has_related_synonym: 2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-3H-purin-6(9H)-one
has_related_synonym: 2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-9H-purin-6-ol
has_related_synonym: 2-amino-9-(2-hydroxy-1-hydroxymethylethoxymethyl)-6,9-dihydro-1H-6-purinone
has_exact_synonym: 2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-1,9-dihydro-6H-purin-6-one
has_RxCUI: 4678
has_related_synonym: 9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)methyl)guanine
has_related_synonym: 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine
database_cross_reference: Beilstein:3654487
has_related_synonym: C9H13N5O4
id: CHEBI:465284
has_alternative_id: CHEBI:5273
database_cross_reference: ChEMBL:10197958
database_cross_reference: ChEMBL:10377226
database_cross_reference: ChEMBL:10411487
database_cross_reference: ChEMBL:10447945
database_cross_reference: ChEMBL:10560739
database_cross_reference: ChEMBL:10691698
database_cross_reference: ChEMBL:10882370
database_cross_reference: ChEMBL:10882372
database_cross_reference: ChEMBL:10882374
database_cross_reference: ChEMBL:10882375
database_cross_reference: ChEMBL:10888336
database_cross_reference: ChEMBL:10966740
database_cross_reference: ChEMBL:10966745
database_cross_reference: ChEMBL:10999475
database_cross_reference: ChEMBL:11229780
database_cross_reference: ChEMBL:11262090
database_cross_reference: ChEMBL:11412988
database_cross_reference: ChEMBL:11454465
database_cross_reference: ChEMBL:11472207
database_cross_reference: ChEMBL:11495586
database_cross_reference: ChEMBL:11585457
database_cross_reference: ChEMBL:11677126
database_cross_reference: ChEMBL:11708924
database_cross_reference: ChEMBL:11708929
database_cross_reference: ChEMBL:11754587
database_cross_reference: ChEMBL:11814776
database_cross_reference: ChEMBL:11858989
database_cross_reference: ChEMBL:11985471
database_cross_reference: ChEMBL:12408716
database_cross_reference: ChEMBL:12459010
database_cross_reference: ChEMBL:12723951
database_cross_reference: ChEMBL:1310744
database_cross_reference: ChEMBL:1319491
database_cross_reference: ChEMBL:1323678
database_cross_reference: ChEMBL:14521407
database_cross_reference: ChEMBL:14584954
database_cross_reference: ChEMBL:14643328
database_cross_reference: ChEMBL:14643358
database_cross_reference: ChEMBL:14736238
database_cross_reference: ChEMBL:15027877
database_cross_reference: ChEMBL:15081019
database_cross_reference: ChEMBL:15481985
database_cross_reference: ChEMBL:15509173
database_cross_reference: ChEMBL:15509174
database_cross_reference: ChEMBL:15509175
database_cross_reference: ChEMBL:15509176
database_cross_reference: ChEMBL:15615545
database_cross_reference: ChEMBL:15634003
database_cross_reference: ChEMBL:15658858
database_cross_reference: ChEMBL:15658861
database_cross_reference: ChEMBL:15658873
database_cross_reference: ChEMBL:15689173
database_cross_reference: ChEMBL:15745823
database_cross_reference: ChEMBL:15801851
database_cross_reference: ChEMBL:16134946
database_cross_reference: ChEMBL:16392791
database_cross_reference: ChEMBL:16392824
database_cross_reference: ChEMBL:16420056
database_cross_reference: ChEMBL:16480257
database_cross_reference: ChEMBL:1652016
database_cross_reference: ChEMBL:16759112

Disulfiram
type: Class
label: disulfiram
subclass of: organic disulfide
has_related_synonym: 1,1'-dithiobis(N,N-diethylthioformamide)
has_RxCUI: 3554
definition: An organic disulfide that has formula C10H20N2S4.
has_related_synonym: Antabuse (TN)
has_related_synonym: C10H20N2S4
has_related_synonym: CCN(CC)C(=S)SSC(=S)N(CC)CC
id: CHEBI:4659
database_cross_reference: ChemIDplus:97-77-8
has_exact_synonym: Disulfiram
has_related_synonym: InChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3
has_related_synonym: InChIKey=AUZONCFQVSMFAP-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:97-77-8
database_cross_reference: KEGG COMPOUND:C01692
database_cross_reference: KEGG DRUG:D00131
has_related_synonym: N,N,N',N'-tetraethylthiuram disulfide
database_cross_reference: NIST Chemistry WebBook:97-77-8
database_cross_reference: Wikipedia:Disulfiram
has_related_synonym: bis(diethylthiocarbamoyl) disulfide
has_related_synonym: tetraethylthioperoxydicarbonic diamide
has_related_synonym: tetraethylthiuram disulfide
has_related_synonym: tetraethylthiuram disulphide
imported from: dron.owl

benzoxazole
type: Class
subclass of: organic heterobicyclic compound
subclass of: organonitrogen heterocyclic compound
subclass of: oxacycle
id: CHEBI:46700
definition: Compounds based on a fused 1,2- or 1,3-oxazole and benzene bicyclic ring skeleton.
has_related_synonym: benzoxazoles
imported from: dron.owl

hidden amide
type: Class
subclass of: acyclic pseudoketone
subclass of: carboxamide
id: CHEBI:46754
definition: Compounds in which an acyclic carbonyl group is bonded to one or two nitrogen atoms of a ring or ring system.
has_related_synonym: hidden amides
imported from: dron.owl

dipeptide
type: Class
subclass of: oligopeptide
definition: Any molecule that contains two amino-acid residues connected by peptide linkages.
has_related_synonym: C4H6N2O3R2
has_alternative_id: CHEBI:23835
has_alternative_id: CHEBI:4634
id: CHEBI:46761
has_related_synonym: Dipeptid
has_exact_synonym: Dipeptide
database_cross_reference: KEGG COMPOUND:C00107
has_related_synonym: dipeptides
imported from: dron.owl

diether
type: Class
subclass of: ether
id: CHEBI:46786
definition: Organic compounds having two ether functional groups.
has_exact_synonym: diether
has_related_synonym: diethers
imported from: dron.owl

N-acylpiperazine
type: Class
subclass of: piperazines
subclass of: hidden amide
id: CHEBI:46844
has_related_synonym: N-acylpiperazines
imported from: dron.owl

N-alkylpiperazine
type: Class
subclass of: piperazines
id: CHEBI:46845
has_related_synonym: N-alkylpiperazines
imported from: dron.owl

N-arylpiperazine
type: Class
subclass of: piperazines
id: CHEBI:46848
has_related_synonym: N-arylpiperazines
imported from: dron.owl

indolyl carboxylic acid
type: Class
subclass of: indoles
subclass of: carboxylic acid
id: CHEBI:46867
has_related_synonym: indolyl carboxylic acids
imported from: dron.owl

imidazotriazine
type: Class
subclass of: organic heterobicyclic compound
subclass of: organonitrogen heterocyclic compound
id: CHEBI:46906
has_related_synonym: imidazotriazines
imported from: dron.owl

imidazopyridine
type: Class
subclass of: organic heterobicyclic compound
subclass of: organonitrogen heterocyclic compound
id: CHEBI:46908
has_related_synonym: imidazopyridines
imported from: dron.owl

N-sulfonylpiperazine
type: Class
subclass of: sulfonamide
subclass of: N-acylpiperazine
id: CHEBI:46918
has_related_synonym: N-sulfonylpiperazines
imported from: dron.owl

capsaicinoid
type: Class
subclass of: fatty amide
definition: A family of aromatic fatty amides produced as secondary metabolites by chilli peppers.
id: CHEBI:46931
has_related_synonym: capsaicinoids
imported from: dron.owl

anthracenes
type: Class
subclass of: carbotricyclic compound
subclass of: acenes
id: CHEBI:46955
definition: Compounds containing an anthracene skeleton.
imported from: dron.owl

tetrahydrofuranol
type: Class
subclass of: oxolanes
id: CHEBI:47017
has_related_synonym: tetrahydrofuranols
imported from: dron.owl

monohydroxytetrahydrofuran
type: Class
subclass of: tetrahydrofuranol
id: CHEBI:47018
has_related_synonym: monohydroxytetrahydrofurans
imported from: dron.owl

Imipramine
type: Class
label: imipramine
subclass of: tricyclic antidepressant
subclass of: dibenzoazepine
has_related_synonym: 10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine
has_exact_synonym: 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
has_related_synonym: 3-(5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE
has_related_synonym: 5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine
has_RxCUI: 5691
definition: A dibenzoazepine that has formula C19H24N2.
has_related_synonym: Antideprin
database_cross_reference: Beilstein:256892
has_related_synonym: C19H24N2
has_alternative_id: CHEBI:47498
id: CHEBI:47499
has_alternative_id: CHEBI:5881
has_related_synonym: CN(C)CCCN1c2ccccc2CCc2ccccc12
database_cross_reference: ChemIDplus:50-49-7
database_cross_reference: DrugBank:DB00458
database_cross_reference: Gmelin:1572523
has_related_synonym: Imipramin
has_exact_synonym: Imipramine
has_related_synonym: InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3
has_related_synonym: InChIKey=BCGWQEUPMDMJNV-UHFFFAOYSA-N
has_related_synonym: Irmin
database_cross_reference: KEGG COMPOUND:50-49-7
database_cross_reference: KEGG COMPOUND:C07049
has_related_synonym: Melipramine
has_related_synonym: N-(gamma-dimethylaminopropyl)iminodibenzyl
database_cross_reference: NIST Chemistry WebBook:50-49-7
database_cross_reference: PDBeChem:IXX
database_cross_reference: Patent:US2554736
database_cross_reference: Wikipedia:Imipramine
has_related_synonym: imipramine
has_related_synonym: imipraminum
has_related_synonym: imizine
imported from: dron.owl

acetate ester
type: Class
subclass of: carboxylic ester
has_related_synonym: Acetic ester
has_related_synonym: Acetyl ester
definition: Any carboxylic ester where the carboxylic acid component is acetic acid.
has_related_synonym: C2H3O2R
has_alternative_id: CHEBI:13244
has_alternative_id: CHEBI:13799
has_alternative_id: CHEBI:22189
has_alternative_id: CHEBI:2406
id: CHEBI:47622
database_cross_reference: KEGG COMPOUND:C01883
has_related_synonym: acetate
has_related_synonym: acetate esters
has_related_synonym: acetates
has_related_synonym: acetyl ester
has_related_synonym: acetyl esters
imported from: dron.owl

aminoglycoside
type: Class
subclass of: glycoside
id: CHEBI:47779
has_related_synonym: aminoglycosides
imported from: dron.owl

Clomipramine
type: Class
label: clomipramine
subclass of: tricyclic antidepressant
subclass of: dibenzoazepine
has_RxCUI: 2597
has_related_synonym: 3-(3-CHLORO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE
has_related_synonym: 3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine
has_exact_synonym: 3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
has_related_synonym: 3-chloroimipramine
definition: A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
has_related_synonym: C19H23ClN2
has_alternative_id: CHEBI:3754
has_alternative_id: CHEBI:47359
id: CHEBI:47780
has_related_synonym: CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc12
database_cross_reference: ChemIDplus:1323477
database_cross_reference: ChemIDplus:303-49-1
database_cross_reference: CiteXplore:12007764
database_cross_reference: CiteXplore:12084414
database_cross_reference: CiteXplore:16085036
database_cross_reference: CiteXplore:17471183
database_cross_reference: CiteXplore:19810911
has_exact_synonym: Clomipramine
database_cross_reference: DrugBank:DB01242
has_related_synonym: G 34586
has_related_synonym: InChI=1S/C19H23ClN2/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3
has_related_synonym: InChIKey=GDLIGKIOYRNHDA-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:303-49-1
database_cross_reference: KEGG COMPOUND:C06918
database_cross_reference: NIST Chemistry WebBook:303-49-1
database_cross_reference: PDBeChem:CXX
database_cross_reference: Patent:CH371799
database_cross_reference: Patent:US3467650
database_cross_reference: Reaxys:1323477
database_cross_reference: Wikipedia:Clomipramine
has_related_synonym: chlorimipramine
has_related_synonym: monochlorimipramine
imported from: dron.owl

Desipramine
type: Class
label: desipramine
subclass of: tricyclic antidepressant
subclass of: dibenzoazepine
has_related_synonym: 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE
has_exact_synonym: 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine
has_RxCUI: 3247
has_related_synonym: 5-(gamma-methylaminopropyl)iminodibenzyl
definition: A dibenzoazepine that has formula C18H22N2.
has_related_synonym: C18H22N2
has_alternative_id: CHEBI:4448
has_alternative_id: CHEBI:47393
id: CHEBI:47781
has_related_synonym: CNCCCN1c2ccccc2CCc2ccccc12
database_cross_reference: ChemIDplus:1432747
database_cross_reference: ChemIDplus:50-47-5
has_related_synonym: DMI
has_related_synonym: Desipramin
has_exact_synonym: Desipramine
database_cross_reference: DrugBank:DB01151
has_related_synonym: InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3
has_related_synonym: InChIKey=HCYAFALTSJYZDH-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:50-47-5
database_cross_reference: KEGG COMPOUND:C06943
database_cross_reference: KEGG DRUG:D07791
has_related_synonym: N-(3-methylaminopropyl)iminobibenzyl
database_cross_reference: NIST Chemistry WebBook:50-47-5
database_cross_reference: PDBeChem:DSM
database_cross_reference: Wikipedia:Desipramine
has_related_synonym: demethylimipramine
has_related_synonym: desipramina
has_related_synonym: desipramine
has_related_synonym: desipraminum
has_related_synonym: desmethylimipramine
has_related_synonym: monodemethylimipramine
has_related_synonym: norimipramine
imported from: dron.owl

3-oxo steroid
type: Class
subclass of: oxo steroid
has_related_synonym: 3-Oxosteroid
has_related_synonym: 3-oxo steroids
has_related_synonym: 3-oxosteroid
has_related_synonym: 3-oxosteroids
has_alternative_id: CHEBI:13607
has_alternative_id: CHEBI:1653
has_alternative_id: CHEBI:20182
id: CHEBI:47788
database_cross_reference: KEGG COMPOUND:C01876
imported from: dron.owl

dibenzoazepine
type: Class
subclass of: organic heterotricyclic compound
id: CHEBI:47804
has_related_synonym: dibenzazepine
has_exact_synonym: dibenzoazepine
has_related_synonym: dibenzoazepines
imported from: dron.owl

cefepime
type: Class
subclass of: cephalosporin
subclass of: oxime O-ether
has_related_synonym: (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-[(1-methylpyrrolidinium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
has_RxCUI: 20481
has_exact_synonym: 7beta-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(1-methylpyrrolidinium-1-yl)methyl]-3,4-didehydrocepham-4-carboxylate
definition: A cephalosporin bearing (1-methylpyrrolidinium-1-yl)methyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton.
database_cross_reference: Beilstein:7453587
has_related_synonym: C19H24N6O5S2
has_alternative_id: CHEBI:3486
has_alternative_id: CHEBI:473919
id: CHEBI:478164
has_exact_synonym: Cefepime
database_cross_reference: ChEMBL:473919
database_cross_reference: ChEMBL:478164
database_cross_reference: CiteXplore:11084674
database_cross_reference: CiteXplore:11179650
database_cross_reference: CiteXplore:11191931
database_cross_reference: CiteXplore:11260566
database_cross_reference: CiteXplore:11280610
database_cross_reference: CiteXplore:11303846
database_cross_reference: CiteXplore:11306793
database_cross_reference: CiteXplore:11328792
database_cross_reference: CiteXplore:11431192
database_cross_reference: CiteXplore:11442796
database_cross_reference: CiteXplore:11864944
database_cross_reference: CiteXplore:11910959
database_cross_reference: CiteXplore:11964152
database_cross_reference: CiteXplore:12848746
database_cross_reference: CiteXplore:14628573
database_cross_reference: CiteXplore:14642333
database_cross_reference: CiteXplore:15303411
database_cross_reference: CiteXplore:15494381
database_cross_reference: CiteXplore:15830071
database_cross_reference: CiteXplore:15978309
database_cross_reference: CiteXplore:15980347
database_cross_reference: CiteXplore:16207962
database_cross_reference: CiteXplore:16650951
database_cross_reference: CiteXplore:16705389
database_cross_reference: CiteXplore:16930923
database_cross_reference: CiteXplore:17042189
database_cross_reference: CiteXplore:17214092
database_cross_reference: CiteXplore:17323865
database_cross_reference: CiteXplore:17448937
database_cross_reference: CiteXplore:17625777
database_cross_reference: CiteXplore:18025111
database_cross_reference: CiteXplore:18154532
database_cross_reference: CiteXplore:18651542
database_cross_reference: CiteXplore:18673128
database_cross_reference: CiteXplore:18717040
database_cross_reference: CiteXplore:19053894
database_cross_reference: CiteXplore:19304881
database_cross_reference: CiteXplore:21425867
database_cross_reference: DrugBank:DB01413
has_related_synonym: InChI=1S/C19H24N6O5S2/c1-25(5-3-4-6-25)7-10-8-31-17-13(16(27)24(17)14(10)18(28)29)22-15(26)12(23-30-2)11-9-32-19(20)21-11/h9,13,17H,3-8H2,1-2H3,(H3-,20,21,22,26,28,29)/b23-12-/t13-,17-/m1/s1
has_related_synonym: InChIKey=HVFLCNVBZFFHBT-ZKDACBOMSA-N
database_cross_reference: KEGG COMPOUND:88040-23-7
database_cross_reference: KEGG COMPOUND:C08111
database_cross_reference: KEGG DRUG:D02376
database_cross_reference: Patent:DE3307550
database_cross_reference: Patent:US4406899
database_cross_reference: Reaxys:7453587
database_cross_reference: Wikipedia:Cefepime
has_related_synonym: [H][C@]12SCC(C[N+]3(C)CCCC3)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\c1csc(N)n1)C([O-])=O
has_related_synonym: cefepima
has_related_synonym: cefepime
has_exact_synonym: cefepime
has_related_synonym: cefepimum
imported from: dron.owl

Enalapril
type: Class
label: enalapril
subclass of: dicarboxylic acid monoester
subclass of: dipeptide
has_related_synonym: (S)-1-(N-(1-(ethoxycarbonyl)-3-phenylpropyl)-L-alanyl)-L-proline
has_related_synonym: (S)-1-{(S)-2-[1-((S)-Ethoxycarbonyl)-3-phenyl-propylamino]-propionyl}-pyrrolidine-2-carboxylic acid
has_related_synonym: 1-(N-((S)-1-carboxy-3-phenylpropyl)-L-alanyl)-L-proline 1'-ethyl ester
has_RxCUI: 3827
definition: A dicarboxylic acid monoester that is ethyl 4-phenylbutanoate in which a hydrogen alpha to the carboxy group is substituted by the amino group of L-alanyl-L-proline (S-configuration).
database_cross_reference: Beilstein:3657467
has_related_synonym: C20H28N2O5
has_alternative_id: CHEBI:116847
id: CHEBI:4784
database_cross_reference: ChEMBL:10669559
database_cross_reference: ChEMBL:116847
database_cross_reference: ChemIDplus:75847-73-3
database_cross_reference: DrugBank:DB00584
has_exact_synonym: ENALAPRIL
has_exact_synonym: Enalapril
has_related_synonym: InChI=1S/C20H28N2O5/c1-3-27-20(26)16(12-11-15-8-5-4-6-9-15)21-14(2)18(23)22-13-7-10-17(22)19(24)25/h4-6,8-9,14,16-17,21H,3,7,10-13H2,1-2H3,(H,24,25)/t14-,16-,17-/m0/s1
has_related_synonym: InChIKey=GBXSMTUPTTWBMN-XIRDDKMYSA-N
database_cross_reference: KEGG COMPOUND:75847-73-3
database_cross_reference: KEGG COMPOUND:C06977
database_cross_reference: KEGG DRUG:D07892
has_exact_synonym: N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-L-proline
database_cross_reference: Patent:EP12401
database_cross_reference: Patent:US4374829
database_cross_reference: Wikipedia:Enalapril
has_related_synonym: enalapril
has_related_synonym: enalaprila
has_related_synonym: enalaprilum
imported from: dron.owl

ureas
type: Class
subclass of: primary amide
has_alternative_id: CHEBI:27220
has_alternative_id: CHEBI:36947
id: CHEBI:47857
has_related_synonym: urea derivatives
imported from: dron.owl

3-oxo monocarboxylic acid
type: Class
subclass of: oxo monocarboxylic acid
has_related_synonym: 3-Oxo acid
has_related_synonym: 3-oxo monocarboxylic acids
has_related_synonym: C3H2O3R2
has_alternative_id: CHEBI:13600
has_alternative_id: CHEBI:1619
has_alternative_id: CHEBI:35949
id: CHEBI:47881
database_cross_reference: KEGG COMPOUND:C01656
imported from: dron.owl

3-oxo Delta(4)-steroid
type: Class
subclass of: 3-oxo steroid
subclass of: enone
has_related_synonym: 3-Oxo-delta4-steroid
has_related_synonym: 3-oxo Delta(4)-steroids
has_related_synonym: 3-oxo-Delta(4)-steroid
has_alternative_id: CHEBI:13604
has_alternative_id: CHEBI:1626
has_alternative_id: CHEBI:20157
id: CHEBI:47909
database_cross_reference: KEGG COMPOUND:C00619
imported from: dron.owl

2',3'-dideoxyribonucleoside
type: Class
subclass of: deoxyribonucleoside
has_related_synonym: 2',3'-dideoxyribonucleosides
id: CHEBI:47945
imported from: dron.owl

vinorelbine
type: Class
subclass of: vinca alkaloid
has_RxCUI: 39541
definition: A vinca alkaloid with a norvinblastine skeleton.
database_cross_reference: Beilstein:9035861
has_related_synonym: C45H54N4O8
id: CHEBI:480999
database_cross_reference: ChEMBL:480999
database_cross_reference: ChemIDplus:71486-22-1
database_cross_reference: DrugBank:71486-22-1
database_cross_reference: DrugBank:DB00361
has_related_synonym: InChI=1S/C45H54N4O8/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3/t28-,37-,38+,39+,42+,43+,44-,45+/m0/s1
has_related_synonym: InChIKey=GBABOYUKABKIAF-GHYRFKGUSA-N
database_cross_reference: KEGG DRUG:71486-22-1
database_cross_reference: KEGG DRUG:D08680
has_related_synonym: Nor-5'-anhydrovinblastine
database_cross_reference: Patent:JP8031096
database_cross_reference: Patent:US4307100
has_exact_synonym: methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-acetoxy-15-[(6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate
has_related_synonym: vinorelbina
has_related_synonym: vinorelbine
has_related_synonym: vinorelbinum
imported from: dron.owl

sulfamate ester
type: Class
subclass of: ester
id: CHEBI:48199
has_related_synonym: sulfamate esters
imported from: dron.owl

disulfide
type: Class
subclass of: sulfur molecular entity
id: CHEBI:48343
definition: Compounds of structure RSSR'.
has_related_synonym: disulfides
imported from: dron.owl

biphenylyltetrazole
type: Class
subclass of: biphenyls
subclass of: tetrazoles
id: CHEBI:48420
imported from: dron.owl

pyrimidine 2',3'-dideoxyribonucleoside
type: Class
subclass of: pyrimidine nucleoside
subclass of: 2',3'-dideoxyribonucleoside
id: CHEBI:48441
has_related_synonym: pyrimidine 2',3'-dideoxyribonucleosides
imported from: dron.owl

purine 2',3'-dideoxyribonucleoside
type: Class
subclass of: purine nucleoside
subclass of: 2',3'-dideoxyribonucleoside
id: CHEBI:48442
has_related_synonym: purine 2',3'-dideoxyribonucleosides
imported from: dron.owl

pyrimidinethione
type: Class
subclass of: pyrimidines
id: CHEBI:48546
has_related_synonym: pyrimidinethiones
imported from: dron.owl

hydroxypiperidine
type: Class
subclass of: piperidines
id: CHEBI:48590
has_related_synonym: hydroxypiperidines
imported from: dron.owl

piperidinecarboxamide
type: Class
subclass of: piperidines
subclass of: monocarboxylic acid amide
id: CHEBI:48592
has_related_synonym: piperidinecarboxamides
imported from: dron.owl

pyranoindolizinoquinoline
type: Class
subclass of: organonitrogen heterocyclic compound
subclass of: oxacycle
subclass of: organic heteropentacyclic compound
id: CHEBI:48626
has_related_synonym: pyranoindolizinoquinolines
imported from: dron.owl

benzothiazepine
type: Class
subclass of: organic heterobicyclic compound
subclass of: organonitrogen heterocyclic compound
subclass of: organosulfur heterocyclic compound
id: CHEBI:48684
has_related_synonym: benzothiazepines
imported from: dron.owl

Ethambutol
type: Class
label: ethambutol
subclass of: ethanolamines
subclass of: ethylenediamine derivatives
has_related_synonym: (+)-2,2'-(ethylenediimino)di-1-butanol
has_related_synonym: (+)-N,N'-bis(1-(hydroxymethyl)propyl)ethylenediamine
has_related_synonym: (+)-S,S-ethambutol
has_related_synonym: (+)-ethambutol
has_exact_synonym: (2S,2'S)-2,2'-(ethane-1,2-diyldiimino)dibutan-1-ol
has_related_synonym: (2S,7S)-2,7-diethyl-3,6-diazaoctane-1,8-diol
has_related_synonym: (S,S)-ethambutol
has_RxCUI: 4110
database_cross_reference: Beilstein:6312870
has_related_synonym: C10H24N2O2
has_related_synonym: CC[C@@H](CO)NCCN[C@@H](CC)CO
has_alternative_id: CHEBI:133410
id: CHEBI:4877
has_alternative_id: CHEBI:659237
has_alternative_id: CHEBI:678172
database_cross_reference: ChEMBL:10649975
database_cross_reference: ChEMBL:10891117
database_cross_reference: ChEMBL:10966749
database_cross_reference: ChEMBL:12182855
database_cross_reference: ChEMBL:133410
database_cross_reference: ChEMBL:14695841
database_cross_reference: ChEMBL:14698152
database_cross_reference: ChEMBL:15225698
database_cross_reference: ChEMBL:16005211
database_cross_reference: ChEMBL:16759086
database_cross_reference: ChEMBL:16870429
database_cross_reference: ChEMBL:17210775
database_cross_reference: ChEMBL:17239593
database_cross_reference: ChEMBL:17276683
database_cross_reference: ChEMBL:17315960
database_cross_reference: ChEMBL:17331717
database_cross_reference: ChEMBL:17562368
database_cross_reference: ChEMBL:17851083
database_cross_reference: ChEMBL:17888665
database_cross_reference: ChEMBL:19524332
database_cross_reference: ChEMBL:19648006
database_cross_reference: ChEMBL:3934384
database_cross_reference: ChEMBL:659237
database_cross_reference: ChEMBL:678172
database_cross_reference: ChemIDplus:74-55-5
database_cross_reference: DrugBank:DB00330
has_related_synonym: EMB
has_exact_synonym: Ethambutol
definition: Ethane-1,2-diamine in which one hydrogen attached to each of the nitrogens is sutstituted by a 1-hydroxybutan-2-yl group (S,S-configuration). It is a bacteriostatic antimycobacterial drug, effective against Mycobacterium tuberculosis and some other mycobacteria. It is used (as the dihydrochloride salt) in combination with other antituberculous drugs in the treatment of pulmonary and extrapulmonary tuberculosis; resistant strains of M. tuberculosis are readily produced if ethambutol is used alone.
has_related_synonym: InChI=1S/C10H24N2O2/c1-3-9(7-13)11-5-6-12-10(4-2)8-14/h9-14H,3-8H2,1-2H3/t9-,10-/m0/s1
has_related_synonym: InChIKey=AEUTYOVWOVBAKS-UWVGGRQHSA-N
database_cross_reference: KEGG COMPOUND:74-55-5
database_cross_reference: KEGG COMPOUND:C06984
database_cross_reference: KEGG DRUG:D07925
has_related_synonym: S,S-Ethambutol
database_cross_reference: Wikipedia:Ethambutol
has_related_synonym: etambutol
has_related_synonym: ethambutol
has_related_synonym: ethambutolum
imported from: dron.owl

benzothiadiazole
type: Class
subclass of: organic heterotricyclic compound
subclass of: organonitrogen heterocyclic compound
subclass of: organosulfur heterocyclic compound
id: CHEBI:48864
has_related_synonym: benzothiadiazoles
imported from: dron.owl

thiadiazolidine
type: Class
subclass of: organic heteromonocyclic compound
subclass of: organonitrogen heterocyclic compound
subclass of: organosulfur heterocyclic compound
id: CHEBI:48865
has_related_synonym: thiadiazolidines
imported from: dron.owl

thiazoles
type: Class
subclass of: organic heteromonocyclic compound
subclass of: organonitrogen heterocyclic compound
subclass of: organosulfur heterocyclic compound
subclass of: monocyclic heteroarene
id: CHEBI:48901
imported from: dron.owl

1,2-thiazole
type: Class
subclass of: thiazoles
has_related_synonym: 1,2-thiazoles
id: CHEBI:48902
has_related_synonym: isothiazoles
imported from: dron.owl

Etidronate
type: Class
label: etidronic acid
subclass of: phosphonic acids
has_related_synonym: (1-Hydroxyethylene)diphosphonic acid
has_related_synonym: (1-Hydroxyethylidene)bis(phosphonic acid)
has_related_synonym: (1-Hydroxyethylidene)bisphosphonic acid
has_related_synonym: (1-Hydroxyethylidene)diphosphonic acid
has_exact_synonym: (1-hydroxyethane-1,1-diyl)bis(phosphonic acid)
has_related_synonym: (Hydroxyethylidene)diphosphonic acid
has_related_synonym: 1,1,1-Ethanetriol diphosphonate
has_related_synonym: 1-Hydroxy-1,1-diphosphonoethane
has_related_synonym: 1-Hydroxyethane-1,1-bisphosphonic acid
has_related_synonym: 1-Hydroxyethane-1,1-diphosphonate
has_related_synonym: 1-Hydroxyethane-1,1-diphosphonic acid
has_related_synonym: 1-Hydroxyethanediphosphonic acid
has_related_synonym: 1-Hydroxyethylidene-1,1-bisphosphonate
has_related_synonym: 1-Hydroxyethylidene-1,1-diphosphonic acid
has_RxCUI: 42682
definition: A phosphonic acid consisting of (ethane-1,1-diyl)bis(phosphonic acid) having a hydroxy substituent at the 1-position. Inhibits formation, growth, and dissolution of hydroxyapatite crystals by chemisorption to calcium phosphate surfaces
has_related_synonym: Acetodiphosphonic acid
has_related_synonym: C2H8O7P2
has_related_synonym: CC(O)(P(O)(O)=O)P(O)(O)=O
id: CHEBI:4907
has_alternative_id: CHEBI:63588
database_cross_reference: ChemIDplus:2809-21-4
database_cross_reference: CiteXplore:10385693
database_cross_reference: CiteXplore:17157266
database_cross_reference: CiteXplore:17214981
database_cross_reference: CiteXplore:18313802
database_cross_reference: DrugBank:DB01077
has_related_synonym: EHDP
has_related_synonym: Ethane-1-hydroxy-1,1-diphosphonate
has_related_synonym: Ethane-1-hydroxy-1,1-diphosphonic acid
has_related_synonym: Etidronsaeure
has_related_synonym: HEDP
has_related_synonym: Hydroxyethanediphosphonic acid
has_related_synonym: InChI=1S/C2H8O7P2/c1-2(3,10(4,5)6)11(7,8)9/h3H,1H3,(H2,4,5,6)(H2,7,8,9)
has_related_synonym: InChIKey=DBVJJBKOTRCVKF-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:2809-21-4
database_cross_reference: KEGG COMPOUND:C07736
database_cross_reference: KEGG DRUG:D02373
has_related_synonym: Oxyethylidenediphosphonic acid
database_cross_reference: Patent:US3159581
database_cross_reference: Reaxys:1789291
database_cross_reference: Wikipedia:Etidronate
has_related_synonym: acide etidronique
has_related_synonym: acido etidronico
has_related_synonym: acidum etidronicum
has_related_synonym: ethane-1-hydroxy-1,1-bisphosphonic acid
has_related_synonym: etidronate
has_related_synonym: etidronic acid
imported from: dron.owl

Didanosine
type: Class
label: didanosine
subclass of: purine 2',3'-dideoxyribonucleoside
has_exact_synonym: 2',3'-dideoxyinosine
has_related_synonym: 2,3-dideoxyinosine
has_RxCUI: 3364
has_related_synonym: 9-((2R,5S)-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-1H-purin-6(9H)-one
has_related_synonym: 9-((2R,5S)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-1,9-dihydro-purin-6-one
has_related_synonym: 9-((2S,5R)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ol
has_related_synonym: 9-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one
definition: A purine 2',3'-dideoxyribonucleoside that is inosine in which the hydroxy groups at both the 2' and the 3' positions on the sugar moiety have been replaced by hydrogen.
database_cross_reference: Beilstein:3619529
has_related_synonym: C10H12N4O3
has_alternative_id: CHEBI:158219
has_alternative_id: CHEBI:39738
has_alternative_id: CHEBI:4516
has_alternative_id: CHEBI:475381
id: CHEBI:490877
has_alternative_id: CHEBI:668806
database_cross_reference: ChEMBL:10386939
database_cross_reference: ChEMBL:158219
database_cross_reference: ChEMBL:1619614
database_cross_reference: ChEMBL:17046264
database_cross_reference: ChEMBL:475381
database_cross_reference: ChEMBL:490877
database_cross_reference: ChEMBL:668806
database_cross_reference: ChemIDplus:69655-05-6
database_cross_reference: CiteXplore:18549801
has_related_synonym: DDI
has_exact_synonym: Didanosine
database_cross_reference: DrugBank:DB00900
has_related_synonym: InChI=1S/C10H12N4O3/c15-3-6-1-2-7(17-6)14-5-13-8-9(14)11-4-12-10(8)16/h4-7,15H,1-3H2,(H,11,12,16)/t6-,7+/m0/s1
has_related_synonym: InChIKey=BXZVVICBKDXVGW-NKWVEPMBSA-N
database_cross_reference: KEGG COMPOUND:69655-05-6
database_cross_reference: KEGG COMPOUND:C06953
database_cross_reference: KEGG DRUG:D00296
has_related_synonym: OC[C@@H]1CC[C@@H](O1)n1cnc2c1nc[nH]c2=O
database_cross_reference: PDBeChem:2DI
database_cross_reference: Patent:EP206497
database_cross_reference: Wikipedia:Didanosine
has_related_synonym: ddI
has_related_synonym: ddIno
has_related_synonym: didanosina
has_related_synonym: didanosine
has_related_synonym: didanosinum
has_related_synonym: dideoxyinosine
imported from: dron.owl

Etoposide
type: Class
label: etoposide
subclass of: beta-D-glucoside
has_related_synonym: (-)-etoposide
has_exact_synonym: (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside
has_related_synonym: 4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-beta-D-glucopyranoside)
has_related_synonym: 4-demethylepipodophyllotoxin beta-D-ethylideneglucoside
has_RxCUI: 4179
has_related_synonym: 9-((4,6-O-Ethylidine-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-d)-1,3-dioxol-6(5aH)-one
definition: A beta-D-glucoside that has formula C29H32O13.
has_related_synonym: C29H32O13
id: CHEBI:4911
database_cross_reference: ChemIDplus:33419-42-0
database_cross_reference: DrugBank:DB00773
has_related_synonym: Eposin
has_related_synonym: Etopophos
has_exact_synonym: Etoposide
has_related_synonym: Etoposido
has_related_synonym: InChI=1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1
has_related_synonym: InChIKey=VJJPUSNTGOMMGY-MRVIYFEKSA-N
database_cross_reference: KEGG COMPOUND:33419-42-0
database_cross_reference: KEGG COMPOUND:C01576
database_cross_reference: KEGG DRUG:D00125
has_related_synonym: Lastet
database_cross_reference: Patent:US3524844
has_related_synonym: Toposar
has_related_synonym: VP-16
has_related_synonym: Vepesid
database_cross_reference: Wikipedia:Etoposide
has_related_synonym: etoposide
has_related_synonym: etoposidum
has_related_synonym: trans-Etoposide
imported from: dron.owl

dopa
type: Class
subclass of: hydroxyphenylalanine
has_related_synonym: (+-)-3-(3,4-dihydroxyphenyl)alanine
has_related_synonym: (+-)-dopa
has_related_synonym: (R,S)-dopa
has_exact_synonym: 2-amino-3-(3,4-dihydroxyphenyl)propanoic acid
has_related_synonym: 3',4'-dihydroxyphenylalanine
has_related_synonym: 3-hydroxy-DL-tyrosine
has_related_synonym: 3-hydroxytyrosine
definition: A hydroxyphenylalanine that has formula C9H11NO4.
database_cross_reference: Beilstein:1462084
has_related_synonym: C9H11NO4
id: CHEBI:49168
database_cross_reference: ChemIDplus:63-84-3
has_related_synonym: DL-3,4-dopa
has_related_synonym: DL-beta-(3,4-dihydroxyphenyl)alanine
has_related_synonym: DL-dihydroxyphenylalanine
has_related_synonym: DL-dioxyphenylalanine
database_cross_reference: Gmelin:51382
has_related_synonym: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)
has_related_synonym: InChIKey=WTDRDQBEARUVNC-UHFFFAOYSA-N
has_related_synonym: NC(Cc1ccc(O)c(O)c1)C(O)=O
database_cross_reference: NIST Chemistry WebBook:63-84-3
has_related_synonym: beta-(3,4-dihydroxyphenyl)-DL-alpha-alanine
has_related_synonym: dl-beta-(3,4-dihydroxyphenyl)-alpha-alanine
has_exact_synonym: dopa
imported from: dron.owl

exemestane
type: Class
subclass of: 17-oxo steroid
subclass of: 3-oxo Delta(4)-steroid
has_RxCUI: 258494
has_related_synonym: 6-methyleneandrosta-1,4-diene-3,17-dione
has_exact_synonym: 6-methylideneandrosta-1,4-diene-3,17-dione
definition: Androsta-1,4-diene-3,17-dione in which the hydrogens at position 6 are replaced by a double bond to a methylene group.a selective inhibitor of the aromatase (oestrogen synthase) system, it is used in the treatment of advanced breast cancer.
has_related_synonym: C20H24O2
id: CHEBI:4953
database_cross_reference: ChemIDplus:107868-30-4
database_cross_reference: CiteXplore:10882163
database_cross_reference: DrugBank:DB00990
has_exact_synonym: Exemestane
has_related_synonym: InChI=1S/C20H24O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h6,8,11,14-16H,1,4-5,7,9-10H2,2-3H3/t14-,15-,16-,19+,20-/m0/s1
has_related_synonym: InChIKey=BFYIZQONLCFLEV-DAELLWKTSA-N
database_cross_reference: KEGG COMPOUND:107868-30-4
database_cross_reference: KEGG COMPOUND:C08162
database_cross_reference: KEGG DRUG:D00963
database_cross_reference: Wikipedia:Exemestane
has_related_synonym: exemestane
has_related_synonym: exemestano
has_related_synonym: exemestanum
imported from: dron.owl

Indomethacin
type: Class
label: indomethacin
subclass of: indole-3-acetic acids
subclass of: organochlorine compound
has_related_synonym: 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
has_RxCUI: 5781
definition: An indole-3-acetic acid that has formula C19H16ClNO4.
database_cross_reference: Beilstein:497341
has_related_synonym: C19H16ClNO4
has_alternative_id: CHEBI:49660
id: CHEBI:49662
has_alternative_id: CHEBI:5918
database_cross_reference: ChemIDplus:53-86-1
database_cross_reference: Gmelin:1446006
has_exact_synonym: INDOMETHACIN
has_related_synonym: InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
has_related_synonym: InChIKey=CGIGDMFJXJATDK-UHFFFAOYSA-N
has_related_synonym: Indocin
has_related_synonym: Indometacin
has_exact_synonym: Indomethacin
database_cross_reference: KEGG COMPOUND:53-86-1
database_cross_reference: KEGG COMPOUND:C01926
database_cross_reference: KEGG DRUG:D00141
database_cross_reference: NIST Chemistry WebBook:53-86-1
database_cross_reference: PDBeChem:IMN
database_cross_reference: Wikipedia:Indomethacin
has_exact_synonym: [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
imported from: dron.owl

organic amino compound
type: Class
subclass of: organonitrogen compound
subclass of: organic molecular entity
definition: A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups.
id: CHEBI:50047
has_related_synonym: organic amino compounds
imported from: dron.owl

dihydropyridine
type: Class
subclass of: pyridines
id: CHEBI:50075
has_exact_synonym: dihydropyridine
has_related_synonym: dihydropyridines
imported from: dron.owl

Selegiline
type: Class
label: selegiline
subclass of: tertiary amine
subclass of: phenethylamine alkaloid
has_RxCUI: 9639
definition: A phenethylamine alkaloid that has formula C13H17N.
database_cross_reference: Beilstein:2092580
has_related_synonym: C13H17N
has_related_synonym: CC(Cc1ccccc1)N(C)CC#C
id: CHEBI:50217
has_related_synonym: InChI=1S/C13H17N/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13/h1,5-9,12H,10-11H2,2-3H3
has_related_synonym: InChIKey=MEZLKOACVSPNER-UHFFFAOYSA-N
has_exact_synonym: N-methyl-N-(1-methyl-2-phenylethyl)prop-2-yn-1-amine
has_related_synonym: selegilina
has_related_synonym: selegiline
has_related_synonym: selegilinum
imported from: dron.owl

6-methylprednisolone
type: Class
subclass of: 3-oxo steroid
has_related_synonym: (11beta)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
has_exact_synonym: 11beta,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
definition: A 3-oxo steroid that has formula C22H30O5.
database_cross_reference: Beilstein:7113955
has_related_synonym: C22H30O5
id: CHEBI:50366
has_related_synonym: InChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12?,14-,15-,17-,19+,20-,21-,22-/m0/s1
has_related_synonym: InChIKey=VHRSUDSXCMQTMA-UWKORSIYSA-N
imported from: dron.owl

taxane diterpenoid
type: Class
subclass of: diterpenoid
id: CHEBI:50367
has_exact_synonym: taxane diterpenoid
has_related_synonym: taxane diterpenoids
imported from: dron.owl

desferrioxamine
type: Class
subclass of: carboxamide
id: CHEBI:50453
imported from: dron.owl

acyclic desferrioxamine
type: Class
subclass of: desferrioxamine
id: CHEBI:50454
imported from: dron.owl

thiocarbonyl compound
type: Class
subclass of: organosulfur compound
definition: Any compound containing the thiocarbonyl group, C=S.
id: CHEBI:50492
has_related_synonym: thiocarbonyl compounds
imported from: dron.owl

Methimazole
type: Class
label: methimazole
subclass of: imidazoles
subclass of: thiocarbonyl compound
has_related_synonym: 1-METHYL-1,3-DIHYDRO-2H-IMIDAZOLE-2-THIONE
has_related_synonym: 1-Methylimidazole-2(3H)-thione
has_exact_synonym: 1-methyl-1,3-dihydro-2H-imidazole-2-thione
has_RxCUI: 6835
definition: A thiocarbonyl compound that has formula C4H6N2S.
database_cross_reference: Beilstein:108646
has_related_synonym: C4H6N2S
has_alternative_id: CHEBI:44168
id: CHEBI:50673
has_alternative_id: CHEBI:6828
database_cross_reference: ChemIDplus:60-56-0
has_related_synonym: Cn1cc[nH]c1=S
has_related_synonym: Danantizol
database_cross_reference: DrugBank:DB00763
has_related_synonym: Favistan
has_related_synonym: InChI=1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)
has_related_synonym: InChIKey=PMRYVIKBURPHAH-UHFFFAOYSA-N
database_cross_reference: KEGG DRUG:D00401
database_cross_reference: NIST Chemistry WebBook:60-56-0
database_cross_reference: PDBeChem:MMZ
has_related_synonym: Strumazol
has_related_synonym: Tapazole
has_related_synonym: Thacapzol
has_related_synonym: USAF el-30
database_cross_reference: Wikipedia:Methimazole
has_related_synonym: thiamazol
has_related_synonym: thiamazole
has_related_synonym: thiamazolum
has_related_synonym: tiamazol
imported from: dron.owl

Mitoxantrone
type: Class
label: mitoxantrone
subclass of: hydroxyanthraquinones
has_related_synonym: 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE
has_RxCUI: 7005
definition: A hydroxyanthraquinone that has formula C22H28N4O6.
database_cross_reference: Beilstein:2795126
has_related_synonym: C22H28N4O6
has_alternative_id: CHEBI:43919
id: CHEBI:50729
has_alternative_id: CHEBI:6955
database_cross_reference: ChemIDplus:65271-80-9
database_cross_reference: DrugBank:DB01204
has_related_synonym: InChI=1S/C22H28N4O6/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32/h1-4,23-30H,5-12H2
has_related_synonym: InChIKey=KKZJGLLVHKMTCM-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:65271-80-9
database_cross_reference: KEGG COMPOUND:C11195
has_exact_synonym: Mitoxantrone
database_cross_reference: PDBeChem:MIX
database_cross_reference: Patent:DE2835661
database_cross_reference: Patent:US4197249
database_cross_reference: Wikipedia:Mitoxantrone
has_related_synonym: mitoxantrona
has_related_synonym: mitoxantrone
has_related_synonym: mitoxantronum
imported from: dron.owl

montelukast
type: Class
subclass of: alkyl sulfide
subclass of: monocarboxylic acid
subclass of: quinolines
has_related_synonym: (R-(E))-1-(((1-(3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid
has_related_synonym: 1-[[[(1 R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl] phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropaneacetic acid
has_RxCUI: 88249
definition: An alkyl sulfide that has formula C35H36ClNO3S.
database_cross_reference: Beilstein:7896575
has_related_synonym: C35H36ClNO3S
has_alternative_id: CHEBI:49756
id: CHEBI:50730
has_alternative_id: CHEBI:6992
database_cross_reference: ChemIDplus:158966-92-8
database_cross_reference: DrugBank:DB00471
has_related_synonym: InChI=1S/C35H36ClNO3S/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29/h3-12,14-16,20-21,32,40H,13,17-19,22-23H2,1-2H3,(H,38,39)/b15-10+/t32-/m1/s1
has_related_synonym: InChIKey=UCHDWCPVSPXUMX-TZIWLTJVSA-N
database_cross_reference: KEGG COMPOUND:158966-92-8
database_cross_reference: KEGG COMPOUND:C07482
has_exact_synonym: MONTELUKAST
has_exact_synonym: Montelukast
database_cross_reference: PDBeChem:MTK
database_cross_reference: Patent:EP1886997
database_cross_reference: Wikipedia:Montelukast
has_related_synonym: montelukast
has_exact_synonym: {1-[({(1R)-1-{3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl}-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl}sulfanyl)methyl]cyclopropyl}acetic acid
imported from: dron.owl

fluorinated steroid
type: Class
subclass of: steroid
definition: A steroid which is substituted with one or more fluorine atoms in any position.
id: CHEBI:50830
imported from: dron.owl

corticosteroid
type: Class
subclass of: steroid
definition: A natural or synthetic analogue of the hormones secreted by the adrenal gland.
id: CHEBI:50858
has_related_synonym: corticoides
has_related_synonym: corticosteroides
has_related_synonym: corticosteroids
imported from: dron.owl

organic molecular entity
type: Class
subclass of: carbon group molecular entity
definition: Any molecular entity that contains carbon.
has_alternative_id: CHEBI:25700
has_alternative_id: CHEBI:33244
id: CHEBI:50860
has_related_synonym: organic compounds
has_related_synonym: organic entity
has_related_synonym: organic molecular entities
imported from: dron.owl

thiazolidenediones
type: Class
subclass of: thiadiazolidine
id: CHEBI:50990
imported from: dron.owl

primary amino compound
type: Class
subclass of: organic amino compound
definition: A compound formally derived from ammonia by replacing one hydrogen atom by an organyl group.
id: CHEBI:50994
has_related_synonym: primary amino compounds
imported from: dron.owl

secondary amino compound
type: Class
subclass of: organic amino compound
definition: A compound formally derived from ammonia by replacing two hydrogen atoms by organyl groups.
id: CHEBI:50995
has_related_synonym: secondary amino compounds
imported from: dron.owl

tertiary amino compound
type: Class
subclass of: organic amino compound
definition: A compound formally derived from ammonia by replacing three hydrogen atoms by organyl groups.
id: CHEBI:50996
has_related_synonym: tertiary amino compounds
imported from: dron.owl

Flucytosine
type: Class
label: flucytosine
subclass of: organofluorine compound
has_exact_synonym: 4-amino-5-fluoropyrimidin-2(1H)-one
has_RxCUI: 4451
has_related_synonym: 5-FC
has_related_synonym: 5-Fluorocystosine
has_related_synonym: 5-Fluorocytosine
definition: An organofluorine compound that has formula C4H4FN3O.
has_related_synonym: Ancobon (TN)
has_related_synonym: C4H4FN3O
id: CHEBI:5100
database_cross_reference: ChemIDplus:2022-85-7
has_exact_synonym: Flucytosine
has_related_synonym: InChI=1S/C4H4FN3O/c5-2-1-7-4(9)8-3(2)6/h1H,(H3,6,7,8,9)
has_related_synonym: InChIKey=XRECTZIEBJDKEO-UHFFFAOYSA-N
database_cross_reference: KEGG DRUG:2022-85-7
database_cross_reference: KEGG DRUG:D00323
has_related_synonym: Nc1nc(=O)[nH]cc1F
database_cross_reference: Wikipedia:Flucytosine
imported from: dron.owl

nitrogen molecular entity
type: Class
subclass of: pnictogen molecular entity
has_alternative_id: CHEBI:25556
id: CHEBI:51143
has_alternative_id: CHEBI:7594
database_cross_reference: KEGG COMPOUND:C06061
has_related_synonym: Nitrogenous compounds
has_related_synonym: nitrogen compounds
has_related_synonym: nitrogen molecular entities
imported from: dron.owl

Fluoxetine
type: Class
label: fluoxetine
subclass of: benzenoid aromatic compound
has_related_synonym: (+-)-N-methyl-3-phenyl-3-((alpha,alpha,alpha-trifluoro-p-tolyl)oxy)propylamine
has_RxCUI: 4493
definition: A benzenoid aromatic compound that has formula C17H18F3NO.
database_cross_reference: Beilstein:39914106
has_related_synonym: C17H18F3NO
id: CHEBI:5118
has_related_synonym: CNCCC(Oc1ccc(cc1)C(F)(F)F)c1ccccc1
database_cross_reference: ChemIDplus:54910-89-3
database_cross_reference: DrugBank:DB00472
has_related_synonym: InChI=1S/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3
has_related_synonym: InChIKey=RTHCYVBBDHJXIQ-UHFFFAOYSA-N
database_cross_reference: KEGG DRUG:54910-89-3
database_cross_reference: KEGG DRUG:D00326
has_exact_synonym: N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine
database_cross_reference: Patent:DE2500110
database_cross_reference: Patent:US4314081
has_related_synonym: Prozac
database_cross_reference: Wikipedia:Fluoxetine
has_related_synonym: fluoxetina
has_related_synonym: fluoxetine
has_related_synonym: fluoxetinum
imported from: dron.owl

diamminedichloroplatinum
type: Class
subclass of: platinum coordination entity
id: CHEBI:51214
has_related_synonym: Cl2H6N2Pt
database_cross_reference: Gmelin:101110
database_cross_reference: NIST Chemistry WebBook:14913-33-8
has_related_synonym: diammine(dichloro)platinum
has_exact_synonym: diamminedichloridoplatinum
has_exact_synonym: diamminedichloridoplatinum(II)
has_exact_synonym: diamminedichloroplatinum
has_exact_synonym: diamminedichloroplatinum(II)
has_related_synonym: diammineplatinum dichloride
imported from: dron.owl

acenes
type: Class
subclass of: benzenoid aromatic compound
id: CHEBI:51269
definition: Polycyclic aromatic hydrocarbons consisting of fused benzene rings in a rectilinear arrangement and their substitution derivatives.
imported from: dron.owl

acenoquinone
type: Class
subclass of: quinone
subclass of: acenes
id: CHEBI:51285
definition: Quinones containing an acene fused ring system.
has_exact_synonym: acenoquinone
has_related_synonym: acenoquinones
imported from: dron.owl

adamantanes
type: Class
subclass of: carbopolycyclic compound
id: CHEBI:51339
definition: Compounds containing an adamantane skeleton.
imported from: dron.owl

Fluvoxamine
type: Class
label: fluvoxamine
subclass of: 5-methoxyvalerophenone O-(2-aminoethyl)oxime
has_exact_synonym: (1E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]pentan-1-one O-(2-aminoethyl)oxime
has_RxCUI: 42355
definition: A 5-methoxyvalerophenone O-(2-aminoethyl)oxime that has formula C15H21F3N2O2.
database_cross_reference: Beilstein:5583954
has_related_synonym: C15H21F3N2O2
id: CHEBI:5138
has_related_synonym: COCCCC\C(c1ccc(cc1)C(F)(F)F)=N/OCCN
database_cross_reference: ChemIDplus:54739-18-3
database_cross_reference: DrugBank:DB00176
has_exact_synonym: Fluvoxamine
has_related_synonym: InChI=1S/C15H21F3N2O2/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18/h5-8H,2-4,9-11,19H2,1H3/b20-14+
has_related_synonym: InChIKey=CJOFXWAVKWHTFT-XSFVSMFZSA-N
database_cross_reference: KEGG COMPOUND:54739-18-3
database_cross_reference: KEGG COMPOUND:C07571
database_cross_reference: Patent:NL7503310
database_cross_reference: Patent:US4085225
database_cross_reference: Wikipedia:Fluvoxamine
has_related_synonym: fluvoxamina
has_related_synonym: fluvoxamine
has_related_synonym: fluvoxaminum
imported from: dron.owl

cyclopropanes
type: Class
subclass of: alicyclic compound
id: CHEBI:51454
definition: Cyclopropane and its derivatives formed by substitution.
imported from: dron.owl

1,2-benzoxazoles
type: Class
subclass of: benzisoxazole
id: CHEBI:51545
definition: Compounds based on a fused 1,2-oxazole and benzene bicyclic ring skeleton, with the O atom positioned adjacent to one of the positions of ring fusion.
imported from: dron.owl

benzisoxazole
type: Class
subclass of: benzoxazole
id: CHEBI:51549
definition: Compounds based on a fused 1,2-oxazole and benzene bicyclic ring skeleton.
has_related_synonym: benzisoxazoles
imported from: dron.owl

dihydrofuran
type: Class
subclass of: furans
id: CHEBI:51659
definition: Compounds containing a mono-unsaturated furan ring skeleton.
has_related_synonym: dihydrofurans
imported from: dron.owl

enone
type: Class
subclass of: alpha,beta-unsaturated ketone
definition: An alpha,beta-unsaturated ketone of general formula R(1)R(2)C=CR(3)-C(=O)R(4) (R(4) =/= H) in which the C=O function is conjugated to a C=C double bond at the alpha,beta position.
has_related_synonym: C3OR4
id: CHEBI:51689
has_related_synonym: [*]\C([*])=C(\[*])C([*])=O
has_related_synonym: enones
imported from: dron.owl

alpha,beta-unsaturated ketone
type: Class
subclass of: ketone
definition: A ketone of general formula R(1)R(2)C=CR(3)-C(=O)R(4) (R(4) =/= H) or R(1)C#C-C(=O)R(2) (R(2) =/= H) in which the ketonic C=O function is conjugated to an unsaturated C-C bond at the alpha,beta position.
id: CHEBI:51721
has_related_synonym: alpha,beta-unsaturated ketones
imported from: dron.owl

organic polycyclic compound
type: Class
subclass of: polycyclic compound
subclass of: organic cyclic compound
id: CHEBI:51958
has_related_synonym: organic polycyclic compounds
imported from: dron.owl

organic tricyclic compound
type: Class
subclass of: organic polycyclic compound
id: CHEBI:51959
has_related_synonym: organic tricyclic compounds
imported from: dron.owl

tetracyclic diterpenoid
type: Class
subclass of: diterpenoid
definition: A terpenoid having a C20 tetracyclic skeleton.
id: CHEBI:52557
has_related_synonym: tetracyclic diterpenoids
imported from: dron.owl

oxazinoquinoline
type: Class
subclass of: organic heterotricyclic compound
definition: Any organic heterotricyclic compound based on a skeleton comprised of an oxazine ring fused onto a quinoline system.
id: CHEBI:53665
has_related_synonym: oxazinoquinolines
imported from: dron.owl

ifosfamides
type: Class
subclass of: nitrogen mustard
id: CHEBI:55369
definition: Compounds containing an ifosfamide skeleton.
has_related_synonym: isosfamides
imported from: dron.owl

imidazolidinone
type: Class
subclass of: cyclic pseudoketone
subclass of: imidazolidines
definition: An imidazolidine containing one or more oxo groups.
id: CHEBI:55370
has_related_synonym: imidazolidinones
imported from: dron.owl

isoxazoles
type: Class
subclass of: oxazole
has_related_synonym: 1,2-oxazoles
has_alternative_id: CHEBI:46813
id: CHEBI:55373
definition: Oxazoles in which the N and O atoms are adjacent.
has_exact_synonym: isoxazoles
imported from: dron.owl

Haloperidol
type: Class
label: haloperidol
subclass of: organochlorine compound
subclass of: organofluorine compound
subclass of: hydroxypiperidine
has_related_synonym: 1-(3-p-fluorobenzoylpropyl)-4-p-chlorophenyl-4-hydroxypiperidine
has_related_synonym: 4'-fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidinyl)butyrophenone
has_related_synonym: 4'-fluoro-4-(4-hydroxy-4-(4'-chlorophenyl)piperidino)butyrophenone
has_related_synonym: 4-(4-(para-chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone
has_related_synonym: 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one
has_exact_synonym: 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
has_RxCUI: 5093
definition: A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4; and an N-linked p-fluorobutyrophenone moiety.
database_cross_reference: Beilstein:331267
has_related_synonym: C21H23ClFNO2
id: CHEBI:5613
database_cross_reference: ChemIDplus:52-86-8
database_cross_reference: CiteXplore:7602118
database_cross_reference: DrugBank:DB00502
has_related_synonym: Haldol
has_related_synonym: InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
has_related_synonym: InChIKey=LNEPOXFFQSENCJ-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:52-86-8
database_cross_reference: KEGG COMPOUND:C01814
database_cross_reference: KEGG DRUG:D00136
database_cross_reference: NIST Chemistry WebBook:52-86-8
database_cross_reference: Patent:BE577977
database_cross_reference: Patent:GB895309
database_cross_reference: Patent:US3438991
database_cross_reference: Wikipedia:Haloperidol
has_related_synonym: gamma-(4-(p-chlorophenyl)-4-hydroxpiperidino)-p-fluorbutyrophenone
has_related_synonym: haloperidol
has_related_synonym: haloperidolum
imported from: dron.owl

Cladribine
type: Class
label: cladribine
subclass of: purine 2'-deoxyribonucleoside
subclass of: organochlorine compound
has_related_synonym: (2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
definition: 2'-Deoxyadenosine in which the hydrogen at position 2 on the purine ring has been substituted by chlorine. It inhibits the synthesis and repair of DNA, particularly in lymphocytes and monocytes, and is used as an antimetabolite antineoplastic drug for the treatment of lymphoid malignancies including hairy-cell leukaemia and chronic lymphocytic leukaemia.
has_related_synonym: 2-CdA
has_related_synonym: 2-chloro-2'-deoxy-beta-adenosine
has_exact_synonym: 2-chloro-2'-deoxyadenosine
has_related_synonym: 2-chloro-6-amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl)purine
has_related_synonym: 2-chloro-deoxyadenosine
has_related_synonym: 2-chlorodeoxyadenosine
has_related_synonym: 2ClAdo
has_RxCUI: 44157
database_cross_reference: Beilstein:624220
has_related_synonym: C10H12ClN5O3
has_alternative_id: CHEBI:31407
id: CHEBI:567361
has_alternative_id: CHEBI:568373
database_cross_reference: ChEMBL:17526755
database_cross_reference: ChEMBL:18570408
database_cross_reference: ChEMBL:567361
database_cross_reference: ChEMBL:568373
database_cross_reference: ChemIDplus:4291-63-8
has_exact_synonym: Cladribine
has_related_synonym: CldAdo
database_cross_reference: DrugBank:DB00242
has_related_synonym: InChI=1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1
has_related_synonym: InChIKey=PTOAARAWEBMLNO-KVQBGUIXSA-N
database_cross_reference: KEGG DRUG:4291-63-8
database_cross_reference: KEGG DRUG:D01370
database_cross_reference: Patent:EP173059
database_cross_reference: Patent:US4760137
database_cross_reference: Wikipedia:Cladribine
has_related_synonym: cladribina
has_related_synonym: cladribine
has_related_synonym: cladribinum
imported from: dron.owl

heterocyclic compound
type: Class
subclass of: cyclic compound
definition: A cyclic compound having as ring members atoms of at least two different elements.
id: CHEBI:5686
has_exact_synonym: Heterocyclic compound
has_related_synonym: compuesto heterociclico
has_related_synonym: compuestos heterociclicos
has_related_synonym: heterocycle
has_related_synonym: heterocyclic compounds
imported from: dron.owl

Ifosfamide
type: Class
label: ifosfamide
subclass of: ifosfamides
has_related_synonym: 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
has_RxCUI: 5657
definition: A nitrogen mustard alkylating agent used in the treatment of cancer
database_cross_reference: Beilstein:611835
has_related_synonym: C7H15Cl2N2O2P
has_alternative_id: CHEBI:219640
id: CHEBI:5864
database_cross_reference: ChEMBL:219640
database_cross_reference: ChemIDplus:3778-73-2
has_related_synonym: ClCCNP1(=O)OCCCN1CCCl
database_cross_reference: DrugBank:DB01181
has_related_synonym: InChIKey=HOMGKSMUEGBAAB-UHFFFAOYSA-N
has_related_synonym: Iphosphamide
has_related_synonym: Isofosfamide
has_related_synonym: Isophosphamide
database_cross_reference: KEGG COMPOUND:3778-73-2
database_cross_reference: KEGG COMPOUND:C07047
database_cross_reference: KEGG DRUG:D00343
has_exact_synonym: N,3-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
database_cross_reference: Wikipedia:Ifosfamide
has_related_synonym: ifosfamida
has_related_synonym: ifosfamide
has_related_synonym: ifosfamidum
has_related_synonym: isosfamide
imported from: dron.owl

acetal
type: Class
subclass of: diether
definition: A compound having the structure RR'C(OR'')(OR''') (R'', R''' =/= H) and thus diethers of geminal diols. Originally, the term was confined by IUPAC to derivatives of aldehydes (R = H), but it now applies equally to derivatives of ketones (neither R nor R' = H ). Mixed acetals have R'' and R''' groups which differ.
id: CHEBI:59769
has_related_synonym: acetals
imported from: dron.owl

ketal
type: Class
subclass of: acetal
definition: An acetal of formula R2C(OR)2 (R =/= H) derived from a ketone by replacement of the oxo group by two hydrocarbyloxy groups. The class name 'ketals', once abandoned by IUPAC, has been reinstated as a subclass of acetals.
id: CHEBI:59777
has_related_synonym: ketals
imported from: dron.owl

cyclic ketal
type: Class
subclass of: ketal
definition: A ketal in the molecule of which the ketal carbon and one or both oxygen atoms thereon are members of a ring.
id: CHEBI:59779
has_related_synonym: cyclic ketals
imported from: dron.owl

docetaxel
type: Class
label: docetaxel trihydrate
subclass of: hydrate
has_exact_synonym: 4-(acetyloxy)-13alpha-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7beta,10beta-trihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate--water (1/3)
has_RxCUI: 72962
database_cross_reference: Beilstein:10054412
has_related_synonym: C43H59NO17
id: CHEBI:59809
database_cross_reference: ChemIDplus:148408-66-6
database_cross_reference: DrugBank:DB01248
has_related_synonym: InChI=1S/C43H53NO14.3H2O/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45;;;/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52);3*1H2/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+;;;/m0.../s1
has_related_synonym: InChIKey=XCDIRYDKECHIPE-QHEQPUDQSA-N
database_cross_reference: KEGG DRUG:148408-66-6
database_cross_reference: KEGG DRUG:D02165
has_related_synonym: N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxel trihydrate
has_related_synonym: N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol trihydrate
database_cross_reference: Patent:EP253738
database_cross_reference: Patent:US4814470
definition: The trihydrate form of docetaxel. It is used for the treatment of breast, ovarian, and non-small cell lung cancer, and with prednisone or prednisolone in hormone-refractory metastatic prostate cancer.
has_related_synonym: docetaxel
imported from: dron.owl

chemical substance
type: Class
subclass of: chemical entity
definition: A chemical substance is a portion of matter of constant composition, composed of molecular entities of the same type or of different types.
id: CHEBI:59999
has_related_synonym: Chemische Substanz
imported from: dron.owl

mixture
type: Class
subclass of: chemical substance
definition: A mixture is a chemical substance composed of multiple molecules, at least two of which are of a different kind.
id: CHEBI:60004
has_related_synonym: Mischung
imported from: dron.owl

purine deoxyribonucleoside
type: Class
subclass of: deoxyribonucleoside
subclass of: purine nucleoside
definition: A nucleoside having a purine base covalently bonded to a deoxyribose.
id: CHEBI:60173
has_related_synonym: purine deoxyribonucleosides
imported from: dron.owl

isoniazid
type: Class
label: isoniazide
subclass of: carbohydrazide
subclass of: isonicotinic acid
has_related_synonym: 4-pyridinecarbohydrazide
has_RxCUI: 6038
definition: A carbohydrazide obtained by formal condensation between pyridine-4-carboxylic acid and hydrazine.
database_cross_reference: Beilstein:119374
has_related_synonym: C6H7N3O
id: CHEBI:6030
database_cross_reference: ChemIDplus:54-85-3
database_cross_reference: CiteXplore:18220565
database_cross_reference: CiteXplore:19183459
database_cross_reference: CiteXplore:445303
database_cross_reference: Gmelin:82804
has_related_synonym: InChI=1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
has_related_synonym: InChIKey=QRXWMOHMRWLFEY-UHFFFAOYSA-N
has_related_synonym: Isoniazid
has_related_synonym: Isonicotinsaeurehydrazid
database_cross_reference: KEGG COMPOUND:54-85-3
database_cross_reference: KEGG COMPOUND:C07054
database_cross_reference: NIST Chemistry WebBook:54-85-3
has_related_synonym: NNC(=O)c1ccncc1
database_cross_reference: Reaxys:119374
database_cross_reference: Wikipedia:Isoniazid
has_related_synonym: isonicotinic acid hydrazide
has_related_synonym: isonicotinic hydrazide
has_related_synonym: isonicotinohydrazide
has_related_synonym: isonicotinoylhydrazide
has_exact_synonym: pyridine-4-carbohydrazide
has_related_synonym: pyridine-4-carboxylic acid hydrazide
imported from: dron.owl

isonicotinic acid
type: Class
subclass of: pyridinemonocarboxylic acid
has_related_synonym: 4-carboxypyridine
has_related_synonym: 4-pyridinecarboxylic acid
definition: A pyridinemonocarboxylic acid that has formula C6H5NO2.
database_cross_reference: Beilstein:109599
has_related_synonym: C6H5NO2
id: CHEBI:6032
database_cross_reference: ChemIDplus:55-22-1
database_cross_reference: Gmelin:68876
has_related_synonym: InChI=1S/C6H5NO2/c8-6(9)5-1-3-7-4-2-5/h1-4H,(H,8,9)
has_related_synonym: InChIKey=TWBYWOBDOCUKOW-UHFFFAOYSA-N
has_exact_synonym: Isonicotinic acid
database_cross_reference: KEGG COMPOUND:55-22-1
database_cross_reference: KEGG COMPOUND:C07446
database_cross_reference: NIST Chemistry WebBook:55-22-1
has_related_synonym: OC(=O)c1ccncc1
database_cross_reference: Wikipedia:Isonicotinic_Acid
has_related_synonym: gamma-picolinic acid
has_related_synonym: gamma-pyridinecarboxylic acid
has_exact_synonym: isonicotinic acid
has_related_synonym: p-pyridinecarboxylic acid
has_exact_synonym: pyridine-4-carboxylic acid
imported from: dron.owl

Itraconazole
type: Class
label: itraconazole
subclass of: triazoles
subclass of: dioxolane
subclass of: N-arylpiperazine
has_exact_synonym: 2-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one
has_RxCUI: 28031
definition: A dioxolane that has formula C35H38Cl2N8O4.
has_related_synonym: C35H38Cl2N8O4
id: CHEBI:6076
database_cross_reference: ChemIDplus:84625-61-6
has_related_synonym: InChIKey=VHVPQPYKVGDNFY-ZPGVKDDISA-N
has_exact_synonym: Itraconazole
has_related_synonym: Itrizole (TN)
database_cross_reference: KEGG DRUG:84625-61-6
database_cross_reference: KEGG DRUG:D00350
has_related_synonym: Oriconazole
has_related_synonym: Sporanox (TN)
database_cross_reference: Wikipedia:Itraconazole
imported from: dron.owl

nucleoside analogue
type: Class
subclass of: N-glycosyl compound
definition: An analogue of a nucleoside, being an N-glycosyl compound in which the nitrogen-containing moiety is a modified nucleotide base. They are commonly used as antiviral products to prevent viral replication in infected cells.
id: CHEBI:60783
has_related_synonym: nucleoside analogues
imported from: dron.owl

ropivacaine
type: Class
subclass of: piperidinecarboxamide
has_related_synonym: (+-)-ropivacaine
has_related_synonym: 1-propyl-2',6'-dimethyl-2-piperidylcarboxyanilide
has_related_synonym: 1-propyl-2',6'-pipecoloxylidide
has_RxCUI: 35780
has_related_synonym: C17H26N2O
has_related_synonym: CCCN1CCCCC1C(=O)Nc1c(C)cccc1C
id: CHEBI:60802
has_related_synonym: DL-ropivacaine
has_related_synonym: InChI=1S/C17H26N2O/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20)
has_related_synonym: InChIKey=ZKMNUMMKYBVTFN-UHFFFAOYSA-N
has_exact_synonym: N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide
has_related_synonym: N-n-propylpipecolic acid-2,6-xylidide
database_cross_reference: Reaxys:253266
definition: The piperidinecarboxamide obtained by the formal condensation of N-propylpipecolic acid and 2,6-dimethylaniline.
has_related_synonym: rac-ropivacaine
has_related_synonym: racemic ropivacaine
imported from: dron.owl

racemate
type: Class
subclass of: mixture
definition: A racemate is an equimolar mixture of a pair of enantiomers.
id: CHEBI:60911
has_related_synonym: melange racemique
has_related_synonym: racemic mixture
imported from: dron.owl

diastereoisomeric mixture
type: Class
subclass of: mixture
definition: A mixture composed of two or more diastereoisomers (stereoisomers not related as mirror images).
id: CHEBI:60915
has_related_synonym: diastereomeric mixture
imported from: dron.owl

beta-glucoside
type: Class
subclass of: glucoside
definition: A glucoside in which the anomeric carbon of the glycosidic bond is in a beta configuration
id: CHEBI:60980
has_related_synonym: beta-glucosides
imported from: dron.owl

Tacrolimus
type: Class
label: tacrolimus hydrate
subclass of: hydrate
has_related_synonym: (-)-(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone monohydrate
has_exact_synonym: (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone--water (1/1)
has_RxCUI: 42316
definition: A hydrate that is the monohydrate form of tacrolimus.
has_related_synonym: C44H71NO13
id: CHEBI:61057
database_cross_reference: ChemIDplus:109581-93-3
database_cross_reference: DrugBank:DB00864
has_related_synonym: InChI=1S/C44H69NO12.H2O/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7;/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3;1H2/b25-19+,27-21+;/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+;/m0./s1
has_related_synonym: InChIKey=NWJQLQGQZSIBAF-MLAUYUEBSA-N
database_cross_reference: KEGG DRUG:109581-93-3
database_cross_reference: KEGG DRUG:D00107
has_related_synonym: Prograf
has_related_synonym: Protopic
database_cross_reference: Reaxys:6265275
has_related_synonym: tacrolimus
has_related_synonym: tacrolimus monohydrate
has_related_synonym: tsukubaenolide hydrate
imported from: dron.owl

nucleobase-containing molecular entity
type: Class
subclass of: heteroarene
subclass of: nitrogen molecular entity
definition: Any compound that has a nucleobase as a part.
id: CHEBI:61120
has_related_synonym: nucleobase-containing compound
has_related_synonym: nucleobase-containing compounds
has_related_synonym: nucleobase-containing molecular entities
imported from: dron.owl

C21-steroid
type: Class
subclass of: steroid
definition: A steroid compound with a structure based on a 21-carbon (pregnane) skeleton.
id: CHEBI:61313
imported from: dron.owl

3-hydroxy carboxylic acid
type: Class
subclass of: hydroxy carboxylic acid
has_related_synonym: 3-hydroxy carboxylic acids
definition: Any hydroxy carboxylic acid which contains a hydroxy group located beta- to the carboxylic acid group.
id: CHEBI:61355
has_related_synonym: beta-hydroxy carboxylic acid
has_related_synonym: beta-hydroxy carboxylic acids
imported from: dron.owl

glycosyl compound
type: Class
subclass of: carbohydrate derivative
definition: A carbohydrate derivative arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to an oxygen, carbon, nitrogen or sulfur atom of a separate entity.
id: CHEBI:63161
has_related_synonym: glycosyl compounds
imported from: dron.owl

carbohydrate derivative
type: Class
subclass of: organooxygen compound
definition: Any organooxygen compound derived from a carbohydrate by replacement of one or more hydroxy group(s) by an amino group, a thiol group or similar heteroatomic groups. The term also includes derivatives of these compounds.
id: CHEBI:63299
has_related_synonym: carbohydrate derivatives
has_related_synonym: derivatised carbohydrate
has_related_synonym: derivatised carbohydrates
has_related_synonym: derivatized carbohydrate
has_related_synonym: derivatized carbohydrates
imported from: dron.owl

monosaccharide derivative
type: Class
subclass of: carbohydrate derivative
definition: A carbohydrate derivative that is formally obtained from a monosaccharide.
id: CHEBI:63367
has_related_synonym: monosaccharide derivatives
imported from: dron.owl

hexose derivative
type: Class
subclass of: monosaccharide derivative
definition: A monosaccharide derivative that is formally obtained from a hexose.
id: CHEBI:63385
has_related_synonym: hexose derivatives
imported from: dron.owl

ketohexose derivative
type: Class
subclass of: hexose derivative
definition: A hexose derivative that is formally obtained from a ketohexose.
id: CHEBI:63391
has_related_synonym: ketohexose derivatives
imported from: dron.owl

Ribavirin
type: Class
label: ribavirin
subclass of: carboxamide
subclass of: 1-ribosyltriazole
has_exact_synonym: 1-(beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide
has_related_synonym: 1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
has_related_synonym: 1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
has_RxCUI: 9344
definition: A 1-ribosyltriazole that is the 1-ribofuranosyl derivative of 1,2,4-triazole-3-carboxamide. An inhibitor of HCV polymerase.
has_related_synonym: C8H12N4O5
id: CHEBI:63580
has_alternative_id: CHEBI:8840
database_cross_reference: ChemIDplus:36791-04-5
database_cross_reference: ChemIDplus:892462
database_cross_reference: CiteXplore:21827730
database_cross_reference: CiteXplore:22052088
database_cross_reference: CiteXplore:22052220
database_cross_reference: CiteXplore:22156853
database_cross_reference: CiteXplore:22158703
database_cross_reference: CiteXplore:22212566
database_cross_reference: CiteXplore:22212568
database_cross_reference: CiteXplore:22212569
database_cross_reference: CiteXplore:22212572
database_cross_reference: CiteXplore:22212576
database_cross_reference: CiteXplore:22212579
database_cross_reference: CiteXplore:22220723
database_cross_reference: CiteXplore:22239498
database_cross_reference: CiteXplore:22239511
database_cross_reference: DrugBank:DB00811
has_related_synonym: InChI=1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1
has_related_synonym: InChIKey=IWUCXVSUMQZMFG-AFCXAGJDSA-N
database_cross_reference: KEGG DRUG:36791-04-5
database_cross_reference: KEGG DRUG:D00423
has_related_synonym: RBV
database_cross_reference: Reaxys:892462
database_cross_reference: Wikipedia:Ribavirin
has_related_synonym: ribavirin
has_related_synonym: ribavirina
has_related_synonym: ribavirine
has_related_synonym: ribavirinum
imported from: dron.owl

Stavudine
type: Class
label: stavudine
subclass of: organic molecular entity
subclass of: dihydrofuran
subclass of: nucleoside analogue
has_related_synonym: 1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine
has_exact_synonym: 1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
has_related_synonym: 2',3'-Didehydro-3'-deoxythimidine
has_related_synonym: 3'-Deoxy-2'-thymidinene
has_RxCUI: 59763
definition: A nucleoside analogue obtained by formal dehydration across positions 2 and 3 of thymidine. An inhibitor of HIV-1 reverse transcriptase
has_related_synonym: C10H12N2O4
id: CHEBI:63581
has_alternative_id: CHEBI:9253
database_cross_reference: ChemIDplus:3056-17-5
database_cross_reference: DrugBank:DB00649
has_related_synonym: InChI=1S/C10H12N2O4/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8/h2-4,7-8,13H,5H2,1H3,(H,11,14,15)/t7-,8+/m0/s1
has_related_synonym: InChIKey=XNKLLVCARDGLGL-JGVFFNPUSA-N
database_cross_reference: KEGG COMPOUND:3056-17-5
database_cross_reference: KEGG COMPOUND:C07312
database_cross_reference: KEGG DRUG:D00445
database_cross_reference: Patent:EP334368
database_cross_reference: Patent:US5130421
database_cross_reference: Reaxys:618327
has_related_synonym: STV
has_related_synonym: Sanilvudine
has_exact_synonym: Stavudine
database_cross_reference: Wikipedia:Stavudine
has_related_synonym: d4T
has_related_synonym: estavudina
has_related_synonym: stavudine
has_related_synonym: stavudinum
imported from: dron.owl

1-glycosyltriazole
type: Class
subclass of: N-glycosyl compound
subclass of: triazoles
has_related_synonym: 1-glycosyltriazoles
definition: An N-glycosyl compound that consists of any triazole having a glycosyl residue attached at position 1.
id: CHEBI:63593
imported from: dron.owl

1-ribosyltriazole
type: Class
subclass of: 1-glycosyltriazole
id: CHEBI:63594
imported from: dron.owl

Levofloxacin
type: Class
label: levofloxacin
subclass of: Ofloxacin
has_related_synonym: (-)-Ofloxacin
has_related_synonym: (3S)-(-)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid
has_exact_synonym: (3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
has_related_synonym: (S)-(-)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzooxazine-6-carboxylic acid
has_related_synonym: (S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid
has_related_synonym: (S)-Ofloxacin
has_RxCUI: 82122
definition: An optically active form of ofloxacin having (S)-configuration; an inhibitor of bacterial topoisomerase IV and DNA gyrase
has_related_synonym: C18H20FN3O4
id: CHEBI:63598
has_alternative_id: CHEBI:6440
database_cross_reference: ChemIDplus:100986-85-4
database_cross_reference: CiteXplore:21075586
database_cross_reference: CiteXplore:21965436
database_cross_reference: CiteXplore:21974858
database_cross_reference: CiteXplore:22088660
database_cross_reference: CiteXplore:22221614
database_cross_reference: DrugBank:DB01137
database_cross_reference: HMDB:HMDB01929
has_related_synonym: InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)/t10-/m0/s1
has_related_synonym: InChIKey=GSDSWSVVBLHKDQ-JTQLQIEISA-N
database_cross_reference: KEGG COMPOUND:100986-85-4
database_cross_reference: KEGG COMPOUND:C07660
database_cross_reference: KEGG DRUG:D08120
has_related_synonym: L-Ofloxacin
has_related_synonym: Ofloxacin S-(-)-form
database_cross_reference: Reaxys:5385660
database_cross_reference: Wikipedia:Levofloxacin
has_related_synonym: levofloxacin
has_related_synonym: levofloxacine
has_related_synonym: levofloxacino
has_related_synonym: levofloxacinum
imported from: dron.owl

Mefloquine
type: Class
label: mefloquine
subclass of: racemate
has_RxCUI: 6694
definition: A racemate composed of (+)-(11R,2'S)- and (-)-(11S,2'R)-enantiomers of mefloquine. An antimalarial agent which acts as a blood schizonticide; its mechanism of action is unknown.
id: CHEBI:63609
has_alternative_id: CHEBI:6718
database_cross_reference: ChemIDplus:53230-10-7
database_cross_reference: CiteXplore:21118921
database_cross_reference: CiteXplore:21853223
database_cross_reference: CiteXplore:21861987
database_cross_reference: CiteXplore:22006004
database_cross_reference: CiteXplore:22217970
database_cross_reference: CiteXplore:22223333
database_cross_reference: CiteXplore:22232280
database_cross_reference: CiteXplore:22233563
database_cross_reference: CiteXplore:22236373
database_cross_reference: CiteXplore:22245668
database_cross_reference: CiteXplore:22246492
database_cross_reference: DrugBank:DB00358
database_cross_reference: KEGG COMPOUND:53230-10-7
database_cross_reference: KEGG COMPOUND:C07633
database_cross_reference: KEGG DRUG:D04895
has_related_synonym: Racemic mefloquine
database_cross_reference: Reaxys:5306591
database_cross_reference: Wikipedia:Mefloquine
has_related_synonym: [(R*,S*)-2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol
has_related_synonym: [DL-erythro-alpha-2-Piperidyl-2,8-bis(trifluoromethyl)]-4-quinolinemethanol
has_related_synonym: mefloquina
has_related_synonym: mefloquine
has_related_synonym: mefloquinum
has_exact_synonym: rac--(R)-[2,8-bis(trifluoromethyl)quinolin-4-yl][(2S)-piperidin-2-yl]methanol
imported from: dron.owl

Misoprostol
type: Class
label: misoprostol
subclass of: diastereoisomeric mixture
has_related_synonym: (+-)-methyl (1R,2R,3R)-3-hydroxy-2-((E)-(4RS)-4-hydroxy-4-methyl-1-octenyl)-5-oxocyclopentaneheptanoate
has_related_synonym: (11-alpha,13E)-(+-)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester
has_RxCUI: 42331
definition: A diastereoisomeric mixture composed of approximately equal amounts of a double racemate of four of the sixteen possible diastereoisomers of methyl (13E)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oate that is racemic prostaglandin E1 which is lacking the hydroxy group at position 15, but which has an additional hydroxy group at position 16. It is a synthetic prostaglandin E1 analogue, used in the treatment of gastric and duodenal ulcers. A weak abortifacient, it is also used for cervical ripening prior to surgical termination of pregnancy. The (11R,16S)-diastereoisomer is the pharmacologically active form.
has_related_synonym: Arthrotec
id: CHEBI:63610
has_alternative_id: CHEBI:6952
database_cross_reference: ChemIDplus:59122-46-2
database_cross_reference: CiteXplore:10945193
database_cross_reference: CiteXplore:10949752
database_cross_reference: CiteXplore:11136959
database_cross_reference: CiteXplore:1417145
database_cross_reference: CiteXplore:18690850
database_cross_reference: CiteXplore:19740175
database_cross_reference: CiteXplore:2109814
database_cross_reference: CiteXplore:3080288
has_related_synonym: Cytotec
database_cross_reference: DrugBank:DB00929
database_cross_reference: KEGG DRUG:59122-46-2
database_cross_reference: KEGG DRUG:D00419
has_related_synonym: Methyl (+-)-11-alpha,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oate
database_cross_reference: Patent:BE827127
database_cross_reference: Patent:US3965143
database_cross_reference: Reaxys:4155643
database_cross_reference: Wikipedia:Misoprostol
has_related_synonym: misoprostol
has_related_synonym: misoprostolum
imported from: dron.owl

moxifloxacin
type: Class
subclass of: quinolone
subclass of: quinolinemonocarboxylic acid
subclass of: aromatic ether
subclass of: organofluorine compound
subclass of: cyclopropanes
subclass of: pyrrolidinopiperidine
has_related_synonym: 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-((4aS,7aS)-octahydro-6H-pyrrolo(3,4-b)pyridin-6-yl)-4-oxo-3-quinolinecarboxylic acid
has_exact_synonym: 1-cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
has_RxCUI: 139462
definition: A quinolone that consits of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid bearing a cyclopropyl substituent at position 1, a fluoro substitiuent at position 6, a (4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl group at position 7 and a methoxy substituent at position 8. A member of the fluoroquinolone class of antibacterial agents.
has_related_synonym: C21H24FN3O4
id: CHEBI:63611
has_alternative_id: CHEBI:7007
database_cross_reference: ChemIDplus:151096-09-2
database_cross_reference: DrugBank:DB00218
has_related_synonym: InChI=1S/C21H24FN3O4/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24/h7,9,11-12,16,23H,2-6,8,10H2,1H3,(H,27,28)/t11-,16+/m0/s1
has_related_synonym: InChIKey=FABPRXSRWADJSP-MEDUHNTESA-N
database_cross_reference: KEGG COMPOUND:C07663
database_cross_reference: KEGG DRUG:D08237
has_exact_synonym: Moxifloxacin
database_cross_reference: Patent:EP550903
database_cross_reference: Reaxys:8365827
database_cross_reference: Wikipedia:Moxifloxacin
has_related_synonym: moxifloxacin
imported from: dron.owl

Pergolide
type: Class
label: pergolide
subclass of: diamine
has_exact_synonym: (8beta)-8-[(methylsulfanyl)methyl]-6-propylergoline
has_RxCUI: 8047
definition: A diamine that is ergoline in which the beta-hydrogen at position 8 is replaced by a (methylthio)methyl group and the hydrogen attached to the piperidine nitrogen (position 6) is replaced by a propyl group. A dopamine D2 receptor agonist which also has D1 and D2 agonist properties, it is used as the mesylate salt in the management of Parkinson's disease, although it was withdrawn from the U.S. and Canadian markets in 2007 due to an increased risk of cardiac valve dysfunction.
has_related_synonym: C19H26N2S
id: CHEBI:63617
has_alternative_id: CHEBI:8020
database_cross_reference: ChemIDplus:66104-22-1
database_cross_reference: CiteXplore:11852289
database_cross_reference: CiteXplore:15180134
database_cross_reference: CiteXplore:16845152
database_cross_reference: CiteXplore:18071034
database_cross_reference: CiteXplore:2012117
database_cross_reference: DrugBank:DB01186
has_related_synonym: InChI=1S/C19H26N2S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3/t13-,16-,18-/m1/s1
has_related_synonym: InChIKey=YEHCICAEULNIGD-MZMPZRCHSA-N
database_cross_reference: KEGG COMPOUND:66104-22-1
database_cross_reference: KEGG COMPOUND:C07425
database_cross_reference: KEGG DRUG:D08339
database_cross_reference: Patent:US4166182
database_cross_reference: Reaxys:5091461
database_cross_reference: Wikipedia:Pergolide
has_related_synonym: pergolida
has_related_synonym: pergolide
has_related_synonym: pergolidum
imported from: dron.owl

Pravastatin
type: Class
label: pravastatin
subclass of: carboxylic ester
subclass of: secondary alcohol
subclass of: hydroxy monocarboxylic acid
subclass of: carbobicyclic compound
subclass of: 3-hydroxy carboxylic acid
has_related_synonym: (+)-(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(S)-2-methylbutyryl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoic acid
has_exact_synonym: (3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid
has_RxCUI: 42463
definition: A carboxylic ester resulting from the formal condensation or (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin.
has_related_synonym: C23H36O7
id: CHEBI:63618
has_alternative_id: CHEBI:8360
database_cross_reference: ChemIDplus:81093-37-0
database_cross_reference: CiteXplore:21749370
database_cross_reference: CiteXplore:21851379
database_cross_reference: DrugBank:DB00175
database_cross_reference: HMDB:HMDB05022
has_related_synonym: InChI=1S/C23H36O7/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28)/t13-,14-,16+,17+,18+,19-,20-,22-/m0/s1
has_related_synonym: InChIKey=TUZYXOIXSAXUGO-PZAWKZKUSA-N
database_cross_reference: KEGG COMPOUND:81093-37-0
database_cross_reference: KEGG COMPOUND:C01844
database_cross_reference: KEGG DRUG:D08410
database_cross_reference: Reaxys:4825538
database_cross_reference: Wikipedia:Pravastatin
has_related_synonym: pravastatin
has_related_synonym: pravastatin acid
has_related_synonym: pravastatina
has_related_synonym: pravastatine
has_related_synonym: pravastatinum
imported from: dron.owl

Propafenone
type: Class
label: propafenone
subclass of: ketone
subclass of: secondary alcohol
subclass of: secondary amino compound
has_related_synonym: 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanone
has_exact_synonym: 1-{2-[2-hydroxy-3-(propylamino)propoxy]phenyl}-3-phenylpropan-1-one
has_related_synonym: 2-(2'-hydroxy-3'-propylaminopropoxy)-omega-phenylpropiophenone
has_RxCUI: 8754
definition: A ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used as the hydrochloride salt in the management of supraventricular and ventricular arrhythmias.
has_related_synonym: C21H27NO3
has_related_synonym: CCCNCC(O)COc1ccccc1C(=O)CCc1ccccc1
id: CHEBI:63619
has_alternative_id: CHEBI:8465
database_cross_reference: ChemIDplus:54063-53-5
database_cross_reference: CiteXplore:8777484
database_cross_reference: DrugBank:DB01182
has_related_synonym: InChI=1S/C21H27NO3/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17/h3-11,18,22-23H,2,12-16H2,1H3
has_related_synonym: InChIKey=JWHAUXFOSRPERK-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:54063-53-5
database_cross_reference: KEGG COMPOUND:C07381
database_cross_reference: KEGG DRUG:D08435
database_cross_reference: Patent:DE2001431
database_cross_reference: Reaxys:2175182
database_cross_reference: Wikipedia:Propafenone
has_related_synonym: propafenona
has_related_synonym: propafenone
has_related_synonym: propafenonum
imported from: dron.owl

Sotalol
type: Class
label: sotalol
subclass of: ethanolamines
subclass of: sulfonamide
subclass of: secondary alcohol
subclass of: secondary amino compound
subclass of: Restriction
  on property: is_bearer_of
  some values from: non-activating competitive beta-adrenergic receptor binding disposition
has_related_synonym: 4'-(1-hydroxy-2-(isopropylamino)ethyl)methane sulfonanilide
has_RxCUI: 9947
definition: A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is sustituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.
has_related_synonym: C12H20N2O3S
has_related_synonym: CC(C)NCC(O)c1ccc(NS(C)(=O)=O)cc1
id: CHEBI:63622
has_alternative_id: CHEBI:9206
database_cross_reference: ChemIDplus:3930-20-9
database_cross_reference: CiteXplore:20562595
database_cross_reference: CiteXplore:21553267
database_cross_reference: CiteXplore:21854895
database_cross_reference: DrugBank:DB00489
has_related_synonym: InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3
has_related_synonym: InChIKey=ZBMZVLHSJCTVON-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:3930-20-9
database_cross_reference: KEGG COMPOUND:C07309
database_cross_reference: KEGG DRUG:D08525
has_exact_synonym: N-{4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl}methanesulfonamide
database_cross_reference: Reaxys:2380820
has_exact_synonym: Sotalol
database_cross_reference: Wikipedia:Sotalol
has_related_synonym: beta-cardone
has_related_synonym: sotalol
has_related_synonym: sotalolum
imported from: dron.owl

Tinidazole
type: Class
label: tinidazole
subclass of: imidazoles
has_exact_synonym: 1-[2-(ethylsulfonyl)ethyl]-2-methyl-5-nitro-1H-imidazole
has_RxCUI: 10612
definition: 1H-imidazole substituted at C-1 by a (2-ethylsulfonyl)ethyl group, at C-2 by a methyl group and at C-5 by a nitro group. It is used as an antiprotozoal, antibacterial agent.
has_related_synonym: C8H13N3O4S
has_related_synonym: CCS(=O)(=O)CCn1c(C)ncc1[N+]([O-])=O
has_alternative_id: CHEBI:32227
id: CHEBI:63627
database_cross_reference: CiteXplore:5458368
database_cross_reference: DrugBank:DB00911
has_related_synonym: InChI=1S/C8H13N3O4S/c1-3-16(14,15)5-4-10-7(2)9-6-8(10)11(12)13/h6H,3-5H2,1-2H3
has_related_synonym: InChIKey=HJLSLZFTEKNLFI-UHFFFAOYSA-N
database_cross_reference: KEGG DRUG:D01426
database_cross_reference: Patent:US3376311
database_cross_reference: Reaxys:618182
database_cross_reference: Wikipedia:Tinidazole
has_related_synonym: timidazole
imported from: dron.owl

tipranavir
type: Class
subclass of: sulfonamide
has_RxCUI: 190548
has_related_synonym: 3'-((1R)-1-((6R)-5,6-Dihydro-4-hydroxy-2-oxo-6-phenethyl-6-propyl-2H-pyran-3-yl)propyl)-5-(trifluoromethyl)-2-pyridinesulfonanilide
definition: A pyridine-2-sulfonamide substituted at C-5 by a trifluoromethyl group and at the sulfonamide nitrogen by a dihydropyrone-containing m-tolyl substituent. It is an HIV-1 protease inhibitor.
has_related_synonym: C31H33F3N2O5S
id: CHEBI:63628
database_cross_reference: ChemIDplus:174484-41-4
database_cross_reference: CiteXplore:17620375
database_cross_reference: CiteXplore:20368406
database_cross_reference: CiteXplore:21041916
database_cross_reference: CiteXplore:21571982
database_cross_reference: CiteXplore:21576452
database_cross_reference: CiteXplore:21825300
database_cross_reference: CiteXplore:21871444
database_cross_reference: CiteXplore:22007990
database_cross_reference: CiteXplore:22096044
database_cross_reference: CiteXplore:22258921
database_cross_reference: DrugBank:DB00932
has_related_synonym: InChIKey=SUJUHGSWHZTSEU-FYBSXPHGSA-N
database_cross_reference: KEGG DRUG:D08605
has_exact_synonym: N-(3-{(1R)-1-[(6R)-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-5,6-dihydro-2H-pyran-3-yl]propyl}phenyl)-5-(trifluoromethyl)pyridine-2-sulfonamide
database_cross_reference: Reaxys:7698323
has_related_synonym: tipranavir
imported from: dron.owl

tizanidine
type: Class
subclass of: imidazoles
subclass of: benzothiadiazole
definition: 2,1,3-Benzothiadiazole substituted at C-4 by a Delta(1)-imidazolin-2-ylamino group and at C-4 by a chloro group. It is an agonist at alpha2-adrenergic receptor sites.
has_related_synonym: 5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole
has_exact_synonym: 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine
has_RxCUI: 57258
has_related_synonym: C9H8ClN5S
id: CHEBI:63629
has_alternative_id: CHEBI:9608
database_cross_reference: ChemIDplus:51322-75-9
database_cross_reference: ChemIDplus:618691
database_cross_reference: CiteXplore:21317414
database_cross_reference: CiteXplore:21733633
database_cross_reference: CiteXplore:21982341
database_cross_reference: CiteXplore:22196407
database_cross_reference: CiteXplore:22223284
has_related_synonym: Clc1ccc2nsnc2c1NC1=NCCN1
database_cross_reference: DrugBank:DB00697
has_related_synonym: InChI=1S/C9H8ClN5S/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9/h1-2H,3-4H2,(H2,11,12,13)
has_related_synonym: InChIKey=XFYDIVBRZNQMJC-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:51322-75-9
database_cross_reference: KEGG COMPOUND:C07452
database_cross_reference: KEGG DRUG:D08611
database_cross_reference: Patent:US3843668
database_cross_reference: Reaxys:618691
has_exact_synonym: Tizanidine
database_cross_reference: Wikipedia:Tizanidine
has_related_synonym: tizanidina
has_related_synonym: tizanidine
has_related_synonym: tizanidinum
imported from: dron.owl

topiramate
type: Class
subclass of: sulfamate ester
subclass of: cyclic ketal
subclass of: ketohexose derivative
has_related_synonym: 2,3:4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate
has_related_synonym: 2,3:4,5-di-O-isopropylidene-beta-D-fructopyranose sulfamate
has_RxCUI: 38404
definition: A hexose derivative that is 2,3:4,5-di-O-isopropylidene-beta-D-fructopyranose in which the hydroxy group has been converted to the corresponding sulfamate ester. It blocks voltage-dependent sodium channels and is used as an antiepileptic and for the prevention of migraine.
has_related_synonym: C12H21NO8S
id: CHEBI:63631
has_alternative_id: CHEBI:9633
database_cross_reference: ChemIDplus:97240-79-4
database_cross_reference: CiteXplore:22233396
database_cross_reference: CiteXplore:22249827
database_cross_reference: DrugBank:DB00273
has_related_synonym: InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1
has_related_synonym: InChIKey=KJADKKWYZYXHBB-XBWDGYHZSA-N
database_cross_reference: KEGG COMPOUND:97240-79-4
database_cross_reference: KEGG COMPOUND:C07502
database_cross_reference: KEGG DRUG:D00537
has_related_synonym: McN-4853
database_cross_reference: Patent:US4513006
has_related_synonym: RWJ-17021
database_cross_reference: Reaxys:5988957
has_related_synonym: TPM
has_related_synonym: Topamax
has_exact_synonym: Topiramate
database_cross_reference: Wikipedia:Topiramate
has_related_synonym: tipiramate
has_related_synonym: tipiramato
has_related_synonym: topiramate
has_related_synonym: topiramato
has_related_synonym: topiramatum
imported from: dron.owl

Topotecan
type: Class
label: topotecan
subclass of: pyranoindolizinoquinoline
has_exact_synonym: (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
has_RxCUI: 57308
has_related_synonym: 9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecin
definition: A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.
has_related_synonym: C23H23N3O5
has_related_synonym: CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccc(O)c(CN(C)C)c4cc3Cn1c2=O
id: CHEBI:63632
has_alternative_id: CHEBI:9634
database_cross_reference: ChemIDplus:123948-87-8
database_cross_reference: CiteXplore:20574789
database_cross_reference: CiteXplore:21255983
database_cross_reference: CiteXplore:21352915
database_cross_reference: CiteXplore:21910214
database_cross_reference: CiteXplore:22028494
database_cross_reference: CiteXplore:22075006
database_cross_reference: CiteXplore:22136714
database_cross_reference: CiteXplore:22190039
database_cross_reference: DrugBank:DB01030
has_related_synonym: InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1
has_related_synonym: InChIKey=UCFGDBYHRUNTLO-QHCPKHFHSA-N
database_cross_reference: KEGG COMPOUND:123948-87-8
database_cross_reference: KEGG COMPOUND:C11158
database_cross_reference: KEGG DRUG:D08618
database_cross_reference: Patent:EP321122
database_cross_reference: Reaxys:4279441
has_exact_synonym: Topotecan
database_cross_reference: Wikipedia:Topotecan
has_related_synonym: topotecan
has_related_synonym: topotecane
has_related_synonym: topotecanum
imported from: dron.owl

pyrrolidinopiperidine
type: Class
subclass of: organic heterobicyclic compound
subclass of: organonitrogen heterocyclic compound
definition: Any organic heterobicyclic compound containing ortho-fused pyrrolidine and piperidine rings.
id: CHEBI:63697
imported from: dron.owl

lansoprazole
type: Class
subclass of: benzimidazoles
subclass of: pyridines
subclass of: sulfoxide
subclass of: Restriction
  on property: is_bearer_of
  some values from: function-inhibiting hydrogen/potassium adenosine triphosphatase enzyme (H+/K+ ATPase) binding disposition
has_RxCUI: 17128
has_exact_synonym: 2-({[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl}sulfinyl)-1H-benzimidazole
definition: A sulfoxide that has formula C16H14F3N3O2S.
has_related_synonym: AG 1749
has_related_synonym: Bamalite
database_cross_reference: Beilstein:4333393
has_related_synonym: C16H14F3N3O2S
id: CHEBI:6375
database_cross_reference: ChemIDplus:103577-45-3
has_related_synonym: InChIKey=MJIHNNLFOKEZEW-UHFFFAOYSA-N
database_cross_reference: KEGG DRUG:D00355
has_related_synonym: Lanzol
has_related_synonym: Lanzopral
has_related_synonym: Lanzul
has_related_synonym: Limpidex
has_related_synonym: Monolitum
has_related_synonym: Ogastro
has_related_synonym: Opiren
database_cross_reference: Patent:EP174726
database_cross_reference: Patent:US4628098
has_related_synonym: Prevacid
database_cross_reference: Wikipedia:Lansoprazole
has_related_synonym: lansoprazol
has_related_synonym: lansoprazolum
imported from: dron.owl

leflunomide
type: Class
subclass of: monocarboxylic acid amide
subclass of: organofluorine compound
subclass of: isoxazoles
has_RxCUI: 27169
has_related_synonym: 5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide
has_related_synonym: 5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide
has_exact_synonym: 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
definition: An isoxazole that has formula C12H9F3N2O2.
has_related_synonym: Arava (TN)
database_cross_reference: Beilstein:4323174
has_related_synonym: C12H9F3N2O2
id: CHEBI:6402
has_related_synonym: Cc1oncc1C(=O)Nc1ccc(cc1)C(F)(F)F
database_cross_reference: ChemIDplus:75706-12-6
has_related_synonym: InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)
has_related_synonym: InChIKey=VHOGYURTWQBHIL-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:75706-12-6
database_cross_reference: KEGG COMPOUND:C07905
database_cross_reference: KEGG DRUG:D00749
has_exact_synonym: Leflunomide
database_cross_reference: Wikipedia:Leflunomide
has_related_synonym: alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide
imported from: dron.owl

Leuprolide
type: Class
label: leuprolide
subclass of: oligopeptide
has_related_synonym: (D-Leu(6),des-Gly-NH2(10),Pro-ethylamide(9))-gonadotropin-releasing hormone
has_RxCUI: 42375
has_exact_synonym: 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide
definition: An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, D-leucyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence. It is a synthetic nonapeptide analogue of gonadotropin-releasing hormone, and is used as a subcutaneous hydrogel implant (particularly as the acetate salt) for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.
has_related_synonym: C59H84N16O12
id: CHEBI:6427
database_cross_reference: ChemIDplus:53714-56-0
database_cross_reference: DrugBank:DB00007
has_related_synonym: InChI=1S/C59H84N16O12/c1-6-63-57(86)48-14-10-22-75(48)58(87)41(13-9-21-64-59(60)61)68-51(80)42(23-32(2)3)69-52(81)43(24-33(4)5)70-53(82)44(25-34-15-17-37(77)18-16-34)71-56(85)47(30-76)74-54(83)45(26-35-28-65-39-12-8-7-11-38(35)39)72-55(84)46(27-36-29-62-31-66-36)73-50(79)40-19-20-49(78)67-40/h7-8,11-12,15-18,28-29,31-33,40-48,65,76-77H,6,9-10,13-14,19-27,30H2,1-5H3,(H,62,66)(H,63,86)(H,67,78)(H,68,80)(H,69,81)(H,70,82)(H,71,85)(H,72,84)(H,73,79)(H,74,83)(H4,60,61,64)/t40-,41-,42-,43+,44-,45-,46-,47-,48-/m0/s1
has_related_synonym: InChIKey=GFIJNRVAKGFPGQ-LIJARHBVSA-N
database_cross_reference: KEGG COMPOUND:53714-56-0
database_cross_reference: KEGG COMPOUND:C07612
database_cross_reference: KEGG DRUG:D08113
has_related_synonym: L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-L-proline ethylamide
has_related_synonym: Leuprorelin
database_cross_reference: Patent:DE2446005
database_cross_reference: Patent:US4005063
database_cross_reference: Reaxys:741818
has_related_synonym: leuprorelina
has_related_synonym: leuproreline
has_related_synonym: leuprorelinum
has_related_synonym: pGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHC2H5
has_related_synonym: pGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt
imported from: dron.owl

biaryl
type: Class
subclass of: ring assembly
id: CHEBI:64459
imported from: dron.owl

Losartan
type: Class
label: losartan
subclass of: imidazoles
subclass of: biphenylyltetrazole
has_exact_synonym: (2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1H-imidazol-5-yl)methanol
has_related_synonym: (2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol
has_related_synonym: 2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole
has_RxCUI: 52175
definition: A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
database_cross_reference: Beilstein:4770867
has_related_synonym: C22H23ClN6O
has_related_synonym: CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
id: CHEBI:6541
database_cross_reference: ChemIDplus:114798-26-4
database_cross_reference: CiteXplore:15703421
database_cross_reference: DrugBank:DB00678
has_related_synonym: InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
has_related_synonym: InChIKey=PSIFNNKUMBGKDQ-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:114798-26-4
database_cross_reference: KEGG COMPOUND:C07072
database_cross_reference: KEGG DRUG:D08146
has_exact_synonym: Losartan
database_cross_reference: Patent:EP253310
database_cross_reference: Patent:US5138069
database_cross_reference: Reaxys:4770867
database_cross_reference: Wikipedia:Losartan
has_related_synonym: losartan
imported from: dron.owl

Megestrol
type: Class
label: megestrol
subclass of: 17alpha-hydroxy steroid
subclass of: 20-oxo steroid
subclass of: 3-oxo steroid
subclass of: 3-oxo Delta(4)-steroid
has_related_synonym: 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione
has_exact_synonym: 17-hydroxypregna-4,6-diene-3,20-dione
has_RxCUI: 6703
definition: A 17alpha-hydroxy steroid that has formula C22H30O3.
database_cross_reference: Beilstein:3164843
has_related_synonym: C22H30O3
id: CHEBI:6722
database_cross_reference: ChemIDplus:3562-63-8
database_cross_reference: DrugBank:DB00351
has_related_synonym: InChI=1S/C21H28O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h4-5,12,16-18,24H,6-11H2,1-3H3/t16-,17+,18+,19+,20+,21+/m1/s1
has_related_synonym: InChIKey=JBVNBBXAMBZTMQ-CEGNMAFCSA-N
database_cross_reference: KEGG COMPOUND:C07120
database_cross_reference: KEGG DRUG:D08167
has_exact_synonym: Megestrol
has_related_synonym: megestrol
has_related_synonym: megestrolum
imported from: dron.owl

mesalamine
type: Class
subclass of: aromatic amine
has_related_synonym: 3-carboxy-4-hydroxyaniline
has_related_synonym: 5-ASA
has_related_synonym: 5-Aminosalicylic acid
has_exact_synonym: 5-amino-2-hydroxybenzoic acid
has_RxCUI: 52582
definition: An aromatic amine comprising salicylic acid having an amino group at the 5-position.
has_related_synonym: Asacol
has_related_synonym: Asacolitin
database_cross_reference: Beilstein:2090421
has_related_synonym: C7H7NO3
id: CHEBI:6775
has_related_synonym: Canasa
has_related_synonym: Claversal
database_cross_reference: DrugBank:DB00244
has_related_synonym: Fisalamine
has_related_synonym: Iialda
has_related_synonym: InChI=1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11)
has_related_synonym: InChIKey=KBOPZPXVLCULAV-UHFFFAOYSA-N
database_cross_reference: KEGG DRUG:D00377
has_related_synonym: Lixacol
has_related_synonym: Mesalazina
has_related_synonym: Mesalazine
has_related_synonym: Mesalazinum
has_related_synonym: Mesasal
has_related_synonym: Nc1ccc(O)c(c1)C(O)=O
has_related_synonym: Pentasa
has_related_synonym: Rowasa
has_related_synonym: Salofalk
database_cross_reference: Wikipedia:Mesalamine
has_related_synonym: m-Aminosalicylic acid
has_related_synonym: mesalazine
has_related_synonym: p-Aminosalicylsaeure
imported from: dron.owl

Metformin
type: Class
label: metformin
subclass of: guanidines
has_related_synonym: 1,1-Dimethylbiguanide
has_RxCUI: 6809
definition: A guanidine that has formula C4H11N5.
has_related_synonym: C4H11N5
id: CHEBI:6801
has_related_synonym: CN(C)C(=N)NC(N)=N
database_cross_reference: ChemIDplus:657-24-9
has_related_synonym: InChI=1S/C4H11N5/c1-9(2)4(7)8-3(5)6/h1-2H3,(H5,5,6,7,8)
has_related_synonym: InChIKey=XZWYZXLIPXDOLR-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:657-24-9
database_cross_reference: KEGG COMPOUND:C07151
has_exact_synonym: Metformin
has_exact_synonym: N,N-dimethylimidodicarbonimidic diamide
database_cross_reference: Wikipedia:Metformin
imported from: dron.owl

6alpha-methylprednisolone
type: Class
label: Methylprednisolone
subclass of: 6-methylprednisolone
has_related_synonym: (6alpha,11beta)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
has_related_synonym: 1-dehydro-6alpha-methylhydrocortisone
has_exact_synonym: 11beta,17,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
has_RxCUI: 6902
has_related_synonym: 6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
definition: A 6-methylprednisolone that has formula C22H30O5.
database_cross_reference: Beilstein:2340300
has_related_synonym: C22H30O5
id: CHEBI:6888
database_cross_reference: ChemIDplus:83-43-2
has_related_synonym: Delta(1)-6alpha-methylhydrocortisone
database_cross_reference: DrugBank:DB00959
has_related_synonym: InChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1
has_related_synonym: InChIKey=VHRSUDSXCMQTMA-PJHHCJLFSA-N
database_cross_reference: KEGG DRUG:D00407
has_related_synonym: Medrate
has_related_synonym: Medrol
has_related_synonym: Medrone
has_related_synonym: Methylprednisolon
database_cross_reference: NIST Chemistry WebBook:83-43-2
database_cross_reference: Patent:US2897218
database_cross_reference: Patent:US3053832
has_related_synonym: Solomet
has_related_synonym: Urbason
database_cross_reference: Wikipedia:Methylprednisolone
has_related_synonym: methylprednisolone
has_related_synonym: methylprednisolonum
has_related_synonym: metilprednisolona
imported from: dron.owl

Metronidazole
type: Class
label: metronidazole
subclass of: imidazoles
has_related_synonym: 1-(beta-Ethylol)-2-methyl-5-nitro-3-azapyrrole
has_exact_synonym: 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol
has_RxCUI: 6922
has_related_synonym: Arilin
database_cross_reference: Beilstein:611683
has_related_synonym: C6H9N3O3
has_alternative_id: CHEBI:63636
id: CHEBI:6909
has_related_synonym: Cc1ncc(n1CCO)[N+]([O-])=O
database_cross_reference: ChemIDplus:443-48-1
database_cross_reference: CiteXplore:11906111
database_cross_reference: CiteXplore:14702395
database_cross_reference: CiteXplore:15739364
database_cross_reference: CiteXplore:16901452
database_cross_reference: CiteXplore:18397330
database_cross_reference: CiteXplore:19485831
database_cross_reference: CiteXplore:22226009
database_cross_reference: CiteXplore:22252819
has_related_synonym: Clont
database_cross_reference: DrugBank:DB00916
has_related_synonym: Efloran
has_related_synonym: Elyzol
has_related_synonym: Entizol
has_related_synonym: Flagyl
has_related_synonym: Fossyol
definition: Imidazole substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively.
has_related_synonym: InChI=1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3
has_related_synonym: InChIKey=VAOCPAMSLUNLGC-UHFFFAOYSA-N
database_cross_reference: KEGG DRUG:D00409
has_related_synonym: Klion
has_related_synonym: Klont
has_related_synonym: Metrocream
has_related_synonym: Metrogel
has_related_synonym: Metrogel-Vaginal
has_related_synonym: Metrolyl
has_related_synonym: Metrotop
database_cross_reference: NIST Chemistry WebBook:443-48-1
has_related_synonym: Nalox
has_related_synonym: Nidagel
has_related_synonym: Noritate
has_related_synonym: Novonidazol
database_cross_reference: Patent:US2944061
has_related_synonym: Protostat
database_cross_reference: Reaxys:611683
has_related_synonym: Trichex
has_related_synonym: Trichopol
has_related_synonym: Tricowas B
has_related_synonym: Trikacide
has_related_synonym: Trikozol
has_related_synonym: Vagilen
has_related_synonym: Vagimid
has_related_synonym: Vertisal
database_cross_reference: Wikipedia:Metronidazole
has_related_synonym: Zadstat
has_related_synonym: metronidazole
imported from: dron.owl

Nitrofurantoin
type: Class
label: nitrofurantoin
subclass of: furans
subclass of: imidazolidine-2,4-dione
subclass of: C-nitro compound
has_RxCUI: 7454
id: CHEBI:7591
imported from: dron.owl

Nortriptyline
type: Class
label: nortriptyline
subclass of: tricyclic antidepressant
has_related_synonym: 10,11-dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-Delta(5,gamma)-propylamine
has_exact_synonym: 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methylpropan-1-amine
has_related_synonym: 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
has_RxCUI: 7531
definition: A tricyclic antidepressant that has formula C19H21N.
has_related_synonym: Ateben
has_related_synonym: Avantyl
has_related_synonym: Aventyl
has_related_synonym: C19H21N
id: CHEBI:7640
has_related_synonym: CNCCC=C1c2ccccc2CCc2ccccc12
database_cross_reference: ChemIDplus:2216786
database_cross_reference: ChemIDplus:72-69-5
has_related_synonym: InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-11,20H,6,12-14H2,1H3
has_related_synonym: InChIKey=PHVGLTMQBUFIQQ-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:72-69-5
database_cross_reference: KEGG COMPOUND:C07274
database_cross_reference: NIST Chemistry WebBook:72-69-5
has_related_synonym: Noritren
has_exact_synonym: Nortriptyline
has_related_synonym: Psychostyl
has_related_synonym: Sensaval
database_cross_reference: Wikipedia:Nortriptyline
has_related_synonym: demethylamitriptyline
has_related_synonym: desmethylamitriptyline
imported from: dron.owl

Ofloxacin
type: Class
label: ofloxacin
subclass of: organofluorine compound
subclass of: N-alkylpiperazine
subclass of: N-arylpiperazine
subclass of: 3-oxo monocarboxylic acid
subclass of: oxazinoquinoline
has_RxCUI: 7623
has_related_synonym: 8-Fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid
has_exact_synonym: 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
definition: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
has_related_synonym: C18H20FN3O4
has_alternative_id: CHEBI:100146
id: CHEBI:7731
database_cross_reference: ChEMBL:100146
database_cross_reference: CiteXplore:11710934
database_cross_reference: DrugBank:DB01165
has_related_synonym: InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)
has_related_synonym: InChIKey=GSDSWSVVBLHKDQ-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:82419-36-1
database_cross_reference: KEGG COMPOUND:C07321
database_cross_reference: KEGG DRUG:D00453
has_related_synonym: OFLX
database_cross_reference: Wikipedia:Ofloxacin
has_related_synonym: ofloxacin
imported from: dron.owl

Omeprazole
type: Class
label: omeprazole
subclass of: benzimidazoles
subclass of: pyridines
subclass of: aromatic ether
subclass of: sulfoxide
subclass of: Restriction
  on property: is_bearer_of
  some values from: function-inhibiting hydrogen/potassium adenosine triphosphatase enzyme (H+/K+ ATPase) binding disposition
has_exact_synonym: 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole
has_related_synonym: 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole
has_RxCUI: 7646
definition: A sulfoxide having 3-methoxybenzimidazol-3-yl and 4-methoxy-3,5-dimethylpyridin-2-ylmethyl groups attached to the sulfur.
has_related_synonym: Antra
has_related_synonym: Audazol
database_cross_reference: Beilstein:3628192
has_related_synonym: Belmazol
has_related_synonym: C17H19N3O3S
id: CHEBI:7772
has_related_synonym: Ceprandal
database_cross_reference: ChemIDplus:73590-58-6
database_cross_reference: CiteXplore:11060758
database_cross_reference: CiteXplore:11208500
database_cross_reference: CiteXplore:11210716
database_cross_reference: CiteXplore:11304936
database_cross_reference: CiteXplore:11321383
database_cross_reference: CiteXplore:11395292
database_cross_reference: CiteXplore:11404722
database_cross_reference: CiteXplore:11459434
database_cross_reference: CiteXplore:11568514
database_cross_reference: CiteXplore:11700946
database_cross_reference: CiteXplore:11774962
database_cross_reference: CiteXplore:11807212
database_cross_reference: CiteXplore:11851112
database_cross_reference: CiteXplore:11903739
database_cross_reference: CiteXplore:11962536
database_cross_reference: CiteXplore:12072663
database_cross_reference: CiteXplore:12135028
database_cross_reference: CiteXplore:12235248
database_cross_reference: CiteXplore:12495367
database_cross_reference: CiteXplore:12683615
database_cross_reference: CiteXplore:13680386
database_cross_reference: CiteXplore:14616415
database_cross_reference: CiteXplore:14708212
database_cross_reference: CiteXplore:14725575
database_cross_reference: CiteXplore:15004262
database_cross_reference: CiteXplore:15125696
database_cross_reference: CiteXplore:15586641
database_cross_reference: CiteXplore:15598025
database_cross_reference: CiteXplore:15684503
database_cross_reference: CiteXplore:15707461
database_cross_reference: CiteXplore:15774534
database_cross_reference: CiteXplore:16080278
database_cross_reference: CiteXplore:16129922
database_cross_reference: CiteXplore:16259581
database_cross_reference: CiteXplore:16276979
database_cross_reference: CiteXplore:16380990
database_cross_reference: CiteXplore:16386527
database_cross_reference: CiteXplore:16397810
database_cross_reference: CiteXplore:16440530
database_cross_reference: CiteXplore:16998872
database_cross_reference: CiteXplore:17049542
database_cross_reference: CiteXplore:17384694
database_cross_reference: CiteXplore:17532167
database_cross_reference: CiteXplore:18294333
database_cross_reference: CiteXplore:18366242
database_cross_reference: CiteXplore:18416943
database_cross_reference: CiteXplore:18448060
database_cross_reference: CiteXplore:18498918
database_cross_reference: CiteXplore:18520598
database_cross_reference: CiteXplore:18571645
database_cross_reference: CiteXplore:18616070
database_cross_reference: CiteXplore:18793272
database_cross_reference: CiteXplore:18818790
database_cross_reference: CiteXplore:19150046
database_cross_reference: CiteXplore:19166730
database_cross_reference: CiteXplore:19176055
database_cross_reference: CiteXplore:19236757
database_cross_reference: CiteXplore:19327607
database_cross_reference: CiteXplore:19383986
database_cross_reference: CiteXplore:19434360
database_cross_reference: CiteXplore:19470853

pantoprazole
type: Class
subclass of: benzimidazoles
subclass of: Restriction
  on property: is_bearer_of
  some values from: function-inhibiting hydrogen/potassium adenosine triphosphatase enzyme (H+/K+ ATPase) binding disposition
has_RxCUI: 40790
has_exact_synonym: 5-(difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole
definition: A benzimidazole that has formula C16H15F2N3O4S.
database_cross_reference: Beilstein:5361474
has_related_synonym: C16H15F2N3O4S
id: CHEBI:7915
database_cross_reference: ChemIDplus:102625-70-7
database_cross_reference: DrugBank:DB00213
has_related_synonym: InChIKey=IQPSEEYGBUAQFF-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:C11806
database_cross_reference: KEGG DRUG:D05353
database_cross_reference: Patent:EP166287
database_cross_reference: Patent:US4758579
database_cross_reference: Wikipedia:Pantoprazole
has_related_synonym: pantoprazol
has_related_synonym: pantoprazole
has_related_synonym: pantoprazolum
imported from: dron.owl

Paroxetine
type: Class
label: paroxetine
subclass of: piperidines
subclass of: aromatic ether
subclass of: organofluorine compound
subclass of: benzodioxoles
has_exact_synonym: (3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine
has_related_synonym: (3S-trans)-3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine
has_RxCUI: 32937
definition: A benzodioxole that consists of piperidine bearing 1,3-benzodioxol-5-yloxy)methyl and 4-fluorophenyl substituents at positions 3 and 4 respectively; the (3S,4R)-diastereomer. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo.
database_cross_reference: Beilstein:7467879
has_related_synonym: C19H20FNO3
id: CHEBI:7936
database_cross_reference: ChemIDplus:61869-08-7
database_cross_reference: CiteXplore:11009210
database_cross_reference: CiteXplore:11169163
database_cross_reference: CiteXplore:11271409
database_cross_reference: CiteXplore:11281965
database_cross_reference: CiteXplore:11324355
database_cross_reference: CiteXplore:11360029
database_cross_reference: CiteXplore:11513198
database_cross_reference: CiteXplore:11563413
database_cross_reference: CiteXplore:11565622
database_cross_reference: CiteXplore:11819027
database_cross_reference: CiteXplore:11893234
database_cross_reference: CiteXplore:11910269
database_cross_reference: CiteXplore:12027788
database_cross_reference: CiteXplore:12088162
database_cross_reference: CiteXplore:12369443
database_cross_reference: CiteXplore:12421645
database_cross_reference: CiteXplore:12818234
database_cross_reference: CiteXplore:12820211
database_cross_reference: CiteXplore:12906023
database_cross_reference: CiteXplore:12920419
database_cross_reference: CiteXplore:14516531
database_cross_reference: CiteXplore:14521492
database_cross_reference: CiteXplore:14566196
database_cross_reference: CiteXplore:14566200
database_cross_reference: CiteXplore:14619895
database_cross_reference: CiteXplore:14624192
database_cross_reference: CiteXplore:14673053
database_cross_reference: CiteXplore:14689334
database_cross_reference: CiteXplore:14978354
database_cross_reference: CiteXplore:15048901
database_cross_reference: CiteXplore:15199661
database_cross_reference: CiteXplore:15241233
database_cross_reference: CiteXplore:15264994
database_cross_reference: CiteXplore:15374134
database_cross_reference: CiteXplore:15376524
database_cross_reference: CiteXplore:15544025
database_cross_reference: CiteXplore:15613191
database_cross_reference: CiteXplore:15845695
database_cross_reference: CiteXplore:15853570
database_cross_reference: CiteXplore:15903129
database_cross_reference: CiteXplore:15963219
database_cross_reference: CiteXplore:15992089
database_cross_reference: CiteXplore:16395417
database_cross_reference: CiteXplore:16397315
database_cross_reference: CiteXplore:16426087
database_cross_reference: CiteXplore:16765127
database_cross_reference: CiteXplore:16822276
database_cross_reference: CiteXplore:16913391
database_cross_reference: CiteXplore:17122538
database_cross_reference: CiteXplore:17162096
database_cross_reference: CiteXplore:17219219
database_cross_reference: CiteXplore:17286545
database_cross_reference: CiteXplore:17452166
database_cross_reference: CiteXplore:17559097
database_cross_reference: CiteXplore:17612590
database_cross_reference: CiteXplore:17652957
database_cross_reference: CiteXplore:17874333
database_cross_reference: CiteXplore:18273418
database_cross_reference: CiteXplore:18345955
database_cross_reference: CiteXplore:18808757
database_cross_reference: CiteXplore:18983224
database_cross_reference: CiteXplore:19687003
database_cross_reference: CiteXplore:19851065
database_cross_reference: CiteXplore:21404089
database_cross_reference: CiteXplore:21452176

Phenytoin
type: Class
label: phenytoin
subclass of: imidazolidine-2,4-dione
has_related_synonym: 5,5-Diphenyl-imidazolidine-2,4-dione
has_related_synonym: 5,5-diphenylimidazolidine-2,4-dione
has_exact_synonym: 5,5-diphenylimidazolidine-2,4-dione
has_related_synonym: 5,5-diphenyltetrahydro-1H-2,4-imidazoledione
has_RxCUI: 8183
definition: A imidazolidine-2,4-dione that consists of hydantoin bearing two phenyl substituents at position 5.
database_cross_reference: Beilstein:384532
has_related_synonym: C15H12N2O2
has_alternative_id: CHEBI:100921
id: CHEBI:8107
database_cross_reference: ChEMBL:100921
database_cross_reference: ChemIDplus:57-41-0
database_cross_reference: CiteXplore:7602118
has_related_synonym: DILANTIN
database_cross_reference: DrugBank:DB00252
has_related_synonym: InChI=1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)
has_related_synonym: InChIKey=CXOFVDLJLONNDW-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:57-41-0
database_cross_reference: KEGG COMPOUND:C07443
database_cross_reference: KEGG DRUG:D00512
has_related_synonym: O=C1NC(=O)C(N1)(c1ccccc1)c1ccccc1
has_related_synonym: PHENTYTOIN
database_cross_reference: Wikipedia:Phenytoin
imported from: dron.owl

pioglitazone
type: Class
subclass of: thiazolidenediones
has_related_synonym: (+-)-5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
has_RxCUI: 33738
has_exact_synonym: 5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione
definition: A thiazolidenedione that has formula C19H20N2O3S.
database_cross_reference: Beilstein:3595485
has_related_synonym: C19H20N2O3S
has_related_synonym: CCc1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1
id: CHEBI:8228
database_cross_reference: ChemIDplus:111025-46-8
database_cross_reference: DrugBank:DB01132
has_related_synonym: InChI=1S/C19H20N2O3S/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23)
has_related_synonym: InChIKey=HYAFETHFCAUJAY-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:111025-46-8
database_cross_reference: KEGG COMPOUND:C07675
database_cross_reference: Patent:EP193256
database_cross_reference: Patent:US4687777
has_exact_synonym: Pioglitazone
database_cross_reference: Wikipedia:Pioglitazone
has_related_synonym: pioglitazona
has_related_synonym: pioglitazone
has_related_synonym: pioglitazonum
imported from: dron.owl

Pramipexole
type: Class
label: pramipexole
subclass of: diamine
subclass of: benzothiazoles
has_related_synonym: (-)-Pramipexole
has_exact_synonym: (6S)-N(6)-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
has_related_synonym: 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N(sup 6)-propyl-, (S)-
has_RxCUI: 746741
definition: A member of the class of benzothiazoles that is 4,5,6,7-tetrahydro-1,3-benzothiazole in which the hydrogens at the 2 and 6-pro-S-positions are substituted by amino and propylamino groups, respectively.
database_cross_reference: Beilstein:6479326
has_related_synonym: C10H17N3S
has_related_synonym: CCCN[C@H]1CCc2nc(N)sc2C1
id: CHEBI:8356
database_cross_reference: ChemIDplus:104632-26-0
database_cross_reference: DrugBank:DB00413
has_related_synonym: InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)/t7-/m0/s1
has_related_synonym: InChIKey=FASDKYOPVNHBLU-ZETCQYMHSA-N
database_cross_reference: KEGG DRUG:D05575
database_cross_reference: Patent:EP186087
database_cross_reference: Patent:US4886812
database_cross_reference: Wikipedia:Pramipexole
has_related_synonym: pramipexol
has_related_synonym: pramipexole
has_related_synonym: pramipexolum
imported from: dron.owl

prednisolone
type: Class
subclass of: glucocorticoid
subclass of: 17alpha-hydroxy steroid
subclass of: 21-hydroxy steroid
subclass of: 11beta-hydroxy steroid
subclass of: 20-oxo steroid
subclass of: 3-oxo steroid
has_related_synonym: (11beta)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione
has_related_synonym: 1,4-pregnadiene-11beta,17alpha,21-triol-3,20-dione
has_related_synonym: 1,4-pregnadiene-3,20-dione-11beta,17alpha,21-triol
has_exact_synonym: 11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione
has_related_synonym: 3,20-dioxo-11beta,17alpha,21-trihydroxy-1,4-pregnadiene
has_RxCUI: 8638
definition: A 21-hydroxy steroid that has formula C21H28O5.
has_related_synonym: C21H28O5
id: CHEBI:8378
database_cross_reference: ChemIDplus:1354103
database_cross_reference: ChemIDplus:50-24-8
has_related_synonym: Delta(1)-dehydrocortisol
has_related_synonym: Delta(1)-dehydrohydrocortisone
has_related_synonym: Delta(1)-hydrocortisone
has_related_synonym: InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
has_related_synonym: InChIKey=OIGNJSKKLXVSLS-VWUMJDOOSA-N
database_cross_reference: KEGG COMPOUND:50-24-8
database_cross_reference: KEGG COMPOUND:C07369
has_exact_synonym: Prednisolone
database_cross_reference: Wikipedia:Prednisolone
has_related_synonym: hydroretrocortine
has_related_synonym: metacortandralone
imported from: dron.owl

6-propyl-2-thiouracil
type: Class
label: Propylthiouracil
subclass of: pyrimidinethione
has_related_synonym: 2,3-dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone
has_related_synonym: 2-Mercapto-6-propyl-4-pyrimidone
has_related_synonym: 2-Mercapto-6-propylpyrimid-4-one
has_related_synonym: 2-Thio-4-oxo-6-propyl-1,3-pyrimidine
has_related_synonym: 2-Thio-6-propyl-1,3-pyrimidin-4-one
has_related_synonym: 4-Propyl-2-thiouracil
has_related_synonym: 4-propyl-2-thiouracil
has_related_synonym: 6-Propyl-2-thio-2,4(1H,3H)pyrimidinedione
has_related_synonym: 6-Propylthiouracil
has_related_synonym: 6-Thio-4-propyluracil
has_exact_synonym: 6-propyl-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one
has_exact_synonym: 6-propyl-2-thiouracil
has_related_synonym: 6-propyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
has_RxCUI: 8794
definition: A pyrimidinethione consisting of uracil in which the 2-oxo group is substituted by a thio group and the hydrogen at position 6 is substituted by a propyl group.
database_cross_reference: Beilstein:130039
has_related_synonym: C7H10N2OS
has_related_synonym: CCCc1cc(=O)[nH]c(=S)[nH]1
id: CHEBI:8502
database_cross_reference: ChemIDplus:51-52-5
database_cross_reference: CiteXplore:11005705
database_cross_reference: CiteXplore:11036881
database_cross_reference: CiteXplore:11350963
database_cross_reference: CiteXplore:11401533
database_cross_reference: CiteXplore:12135875
database_cross_reference: CiteXplore:12922945
database_cross_reference: CiteXplore:14692727
database_cross_reference: CiteXplore:14745920
database_cross_reference: CiteXplore:16380675
database_cross_reference: CiteXplore:16498810
database_cross_reference: CiteXplore:16880639
database_cross_reference: CiteXplore:17365943
database_cross_reference: CiteXplore:17497002
database_cross_reference: CiteXplore:17878268
database_cross_reference: CiteXplore:18055877
database_cross_reference: CiteXplore:18710353
database_cross_reference: CiteXplore:19530273
database_cross_reference: CiteXplore:19578601
database_cross_reference: CiteXplore:20166204
database_cross_reference: CiteXplore:21749382
database_cross_reference: CiteXplore:6387489
database_cross_reference: DrugBank:DB00550
database_cross_reference: Gmelin:1998546
has_related_synonym: InChI=1S/C7H10N2OS/c1-2-3-5-4-6(10)9-7(11)8-5/h4H,2-3H2,1H3,(H2,8,9,10,11)
has_related_synonym: InChIKey=KNAHARQHSZJURB-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:51-52-5
database_cross_reference: KEGG COMPOUND:C07569
database_cross_reference: KEGG DRUG:D00562
database_cross_reference: NIST Chemistry WebBook:51-52-5
has_related_synonym: Propylthiouracil
database_cross_reference: Reaxys:130039
database_cross_reference: Wikipedia:Propylthiouracil
has_related_synonym: propiltiouracilo
has_related_synonym: propylthiouracil
has_related_synonym: propylthiouracile
has_related_synonym: propylthiouracilum
imported from: dron.owl

Protriptyline
type: Class
label: protriptyline
subclass of: tricyclic antidepressant
has_exact_synonym: 3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine
has_related_synonym: 3-(5H-dibenzo[a,d]cyclohepten-5-yl)-N-methyl-1-propanamine
has_related_synonym: 5-(3-methylaminopropyl)-5H-dibenzo[a,d]cycloheptene
has_related_synonym: 7-(3-methylaminopropyl)-1,2:5,6-dibenzocycloheptatriene
has_RxCUI: 8886
definition: A tricyclic antidepressant that has formula C19H21N.
has_related_synonym: C19H21N
id: CHEBI:8597
has_related_synonym: CNCCCC1c2ccccc2C=Cc2ccccc12
database_cross_reference: ChemIDplus:2217411
database_cross_reference: ChemIDplus:438-60-8
has_related_synonym: InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3
has_related_synonym: InChIKey=BWPIARFWQZKAIA-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:438-60-8
database_cross_reference: KEGG COMPOUND:C07408
has_related_synonym: N-methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine
has_related_synonym: N-methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine
database_cross_reference: NIST Chemistry WebBook:438-60-8
has_exact_synonym: Protriptyline
database_cross_reference: Wikipedia:Protriptyline
has_related_synonym: amimetilina
imported from: dron.owl

rabeprazole
type: Class
subclass of: benzimidazoles
subclass of: pyridines
subclass of: sulfoxide
subclass of: Restriction
  on property: is_bearer_of
  some values from: function-inhibiting hydrogen/potassium adenosine triphosphatase enzyme (H+/K+ ATPase) binding disposition
has_RxCUI: 114979
has_exact_synonym: 2-({[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfinyl)-1H-benzimidazole
definition: A sulfoxide that has formula C18H21N3O3S.
database_cross_reference: Beilstein:8159014
has_related_synonym: C18H21N3O3S
id: CHEBI:8768
has_related_synonym: COCCCOc1ccnc(CS(=O)c2nc3ccccc3[nH]2)c1C
database_cross_reference: ChemIDplus:117976-89-3
has_related_synonym: Clofezone
database_cross_reference: DrugBank:DB01129
has_related_synonym: InChI=1S/C18H21N3O3S/c1-13-16(19-9-8-17(13)24-11-5-10-23-2)12-25(22)18-20-14-6-3-4-7-15(14)21-18/h3-4,6-9H,5,10-12H2,1-2H3,(H,20,21)
has_related_synonym: InChIKey=YREYEVIYCVEVJK-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:117976-89-3
database_cross_reference: KEGG COMPOUND:C07864
has_exact_synonym: Rabeprazole
database_cross_reference: Wikipedia:Rabeprazole
has_related_synonym: rabeprazole
imported from: dron.owl

Ramipril
type: Class
label: ramipril
subclass of: dicarboxylic acid monoester
subclass of: azabicycloalkane
subclass of: cyclopentapyrrole
has_exact_synonym: (2S,3aS,6aS)-1-[(2S)-2-{[(1S)-1-ethoxycarbonyl-3-phenylpropyl]amino}propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid
has_related_synonym: (2S-(1(R*(R*)),2alpha,3abeta,6abeta))-1-(2-((1-(Ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acid.
has_RxCUI: 35296
definition: A cyclopentapyrrole that has formula C23H32N2O5.
has_related_synonym: Altace (TN)
database_cross_reference: Beilstein:4214464
has_related_synonym: C23H32N2O5
id: CHEBI:8774
database_cross_reference: ChemIDplus:87333-19-5
has_related_synonym: InChI=1S/C23H32N2O5/c1-3-30-23(29)18(13-12-16-8-5-4-6-9-16)24-15(2)21(26)25-19-11-7-10-17(19)14-20(25)22(27)28/h4-6,8-9,15,17-20,24H,3,7,10-14H2,1-2H3,(H,27,28)/t15-,17-,18-,19-,20-/m0/s1
has_related_synonym: InChIKey=HDACQVRGBOVJII-JBDAPHQKSA-N
database_cross_reference: KEGG DRUG:87333-19-5
database_cross_reference: KEGG DRUG:D00421
has_exact_synonym: Ramipril
has_related_synonym: Tritace
database_cross_reference: Wikipedia:Ramipril
imported from: dron.owl

ropinirole
type: Class
subclass of: indolones
subclass of: tertiary amine
has_exact_synonym: 4-[2-(dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one
has_RxCUI: 72302
definition: An indolone that has formula C16H24N2O.
database_cross_reference: Beilstein:6062222
has_related_synonym: C16H24N2O
has_related_synonym: CCCN(CCC)CCc1cccc2NC(=O)Cc12
id: CHEBI:8888
database_cross_reference: ChemIDplus:91374-21-9
database_cross_reference: DrugBank:DB00268
has_related_synonym: InChI=1S/C16H24N2O/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15/h5-7H,3-4,8-12H2,1-2H3,(H,17,19)
has_related_synonym: InChIKey=UHSKFQJFRQCDBE-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:C07564
database_cross_reference: Patent:US4452808
has_exact_synonym: Ropinirole
database_cross_reference: Wikipedia:Ropinirole
has_related_synonym: ropinirol
has_related_synonym: ropinirole
has_related_synonym: ropinirolum
imported from: dron.owl

Simvastatin
type: Class
label: simvastatin
subclass of: delta-lactone
subclass of: fatty acid ester
has_exact_synonym: (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
has_related_synonym: 2,2-dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one
has_RxCUI: 36567
definition: A fatty acid ester comprising a dihydroxyheptanoic acid unit condensed into a lactone; a partially reduced naphthalene structure; and a 2,2-dimethylbutyric acyl substituent at C17. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
database_cross_reference: Beilstein:4768037
has_related_synonym: C25H38O5
has_alternative_id: CHEBI:45577
id: CHEBI:9150
database_cross_reference: ChemIDplus:79902-63-9
database_cross_reference: DrugBank:DB00641
has_related_synonym: InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1
has_related_synonym: InChIKey=RYMZZMVNJRMUDD-HGQWONQESA-N
database_cross_reference: KEGG DRUG:79902-63-9
database_cross_reference: KEGG DRUG:D00434
has_related_synonym: MK-733
database_cross_reference: Patent:EP33538
database_cross_reference: Patent:US4444784
has_exact_synonym: Simvastatin
has_related_synonym: Simvastatina
has_related_synonym: Simvastatine
has_related_synonym: Simvastatinum
database_cross_reference: Wikipedia:Simvastatin
has_related_synonym: Zocor
has_related_synonym: simvastatin
imported from: dron.owl

Sulfasalazine
type: Class
label: sulfasalazine
subclass of: azobenzenes
subclass of: pyridines
subclass of: sulfonamide
has_related_synonym: 2-Hydroxy-5-((4-((2-pyridinylamino)sulfonyl)phenyl)azo)benzoic acid
has_related_synonym: 2-Hydroxy-5-[4-(pyridin-2-ylsulfamoyl)-phenylazo]-benzoic acid
has_exact_synonym: 2-hydroxy-5-{[4-(pyridin-2-ylsulfamoyl)phenyl]diazenyl}benzoic acid
has_related_synonym: 4-(Pyridyl-2-amidosulfonyl)-3'-carboxy-4'-hydroxyazobenzene
has_related_synonym: 5-((p-(2-Pyridylsulfamoyl)phenyl)azo)salicylic acid
has_related_synonym: 5-(4-(2-Pyridylsulfamoyl)phenylazo)-2-hydroxybenzoic acid
has_related_synonym: 5-(p-(2-Pyridylsulfamyl)phenylazo)salicylic acid
has_RxCUI: 9524
definition: An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
has_related_synonym: Azulfidine
database_cross_reference: Beilstein:356241
database_cross_reference: Beilstein:8132868
has_related_synonym: C18H14N4O5S
has_alternative_id: CHEBI:101223
id: CHEBI:9334
database_cross_reference: ChemIDplus:599-79-1
database_cross_reference: CiteXplore:2434548
database_cross_reference: DrugBank:DB00795
database_cross_reference: Gmelin:2666050
has_related_synonym: InChI=1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+
has_related_synonym: InChIKey=NCEXYHBECQHGNR-QZQOTICOSA-N
database_cross_reference: KEGG COMPOUND:599-79-1
database_cross_reference: KEGG COMPOUND:C07316
database_cross_reference: KEGG DRUG:D00448
database_cross_reference: Patent:US2396145
database_cross_reference: Reaxys:8132868
has_related_synonym: Salazosulfapiridina
has_related_synonym: Salazosulfapyridine
has_related_synonym: Salazosulfapyridinum
has_related_synonym: Salicylazosulfapyridine
has_related_synonym: Sulfasalazina
has_exact_synonym: Sulfasalazine
has_related_synonym: Sulfasalazinum
has_related_synonym: sulfasalazine
imported from: dron.owl

Ticlopidine
type: Class
label: ticlopidine
subclass of: organochlorine compound
subclass of: thienopyridine
has_RxCUI: 10594
has_exact_synonym: 5-(2-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
definition: A thienopyridine that has formula C14H14ClNS.
has_related_synonym: C14H14ClNS
id: CHEBI:9588
database_cross_reference: ChemIDplus:55142-85-3
has_related_synonym: Clc1ccccc1CN1CCc2sccc2C1
database_cross_reference: DrugBank:DB00208
has_related_synonym: InChI=1S/C14H14ClNS/c15-13-4-2-1-3-11(13)9-16-7-5-14-12(10-16)6-8-17-14/h1-4,6,8H,5,7,9-10H2
has_related_synonym: InChIKey=PHWBOXQYWZNQIN-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:C07140
database_cross_reference: Patent:DE2404308
database_cross_reference: Patent:US4051141
database_cross_reference: Patent:US4127580
database_cross_reference: Wikipedia:Ticlopidine
has_related_synonym: ticlopidina
has_related_synonym: ticlopidine
has_related_synonym: ticlopidinum
imported from: dron.owl

Triamcinolone
type: Class
subclass of: fluorinated steroid
has_RxCUI: 10759
id: CHEBI:9667
imported from: dron.owl

Trimipramine
type: Class
label: trimipramine
subclass of: tricyclic antidepressant
subclass of: dibenzoazepine
has_related_synonym: 10,11-dihydro-N,N,beta-trimethyl-5H-dibenz[b,f]azepine-5-propanamine
has_RxCUI: 10834
has_exact_synonym: 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N,2-trimethylpropan-1-amine
has_related_synonym: 5-(gamma-dimethylamino-beta-methylpropyl)-10,11-dihydro-5H-dibenzo[b,f]azepine
has_related_synonym: 5-[3-(dimethylamino)-2-methylpropyl]-10,11-dihydro-5H-dibenz[b,f]azepine
definition: A dibenzoazepine that has formula C20H26N2.
has_related_synonym: C20H26N2
has_related_synonym: CC(CN(C)C)CN1c2ccccc2CCc2ccccc12
id: CHEBI:9738
database_cross_reference: ChemIDplus:1321466
database_cross_reference: ChemIDplus:739-71-9
has_related_synonym: InChI=1S/C20H26N2/c1-16(14-21(2)3)15-22-19-10-6-4-8-17(19)12-13-18-9-5-7-11-20(18)22/h4-11,16H,12-15H2,1-3H3
has_related_synonym: InChIKey=ZSCDBOWYZJWBIY-UHFFFAOYSA-N
database_cross_reference: KEGG DRUG:D00394
database_cross_reference: NIST Chemistry WebBook:739-71-9
has_related_synonym: RP-7162
has_related_synonym: Sapilent
has_related_synonym: Trimeprimine
has_exact_synonym: Trimipramine
database_cross_reference: Wikipedia:Trimipramine
has_related_synonym: beta-methylimipramine
has_related_synonym: trimeproprimine
imported from: dron.owl

venlafaxine
type: Class
subclass of: cyclohexanols
subclass of: tertiary alcohol
subclass of: tertiary amine
has_exact_synonym: 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol
has_RxCUI: 39786
definition: A cyclohexanol that has formula C17H27NO2.
database_cross_reference: Beilstein:4234848
has_related_synonym: C17H27NO2
id: CHEBI:9943
has_related_synonym: COc1ccc(cc1)C(CN(C)C)C1(O)CCCCC1
database_cross_reference: ChemIDplus:93413-69-5
database_cross_reference: DrugBank:DB00285
has_related_synonym: Elafax
has_related_synonym: InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3
has_related_synonym: InChIKey=PNVNVHUZROJLTJ-UHFFFAOYSA-N
database_cross_reference: KEGG COMPOUND:93413-69-5
database_cross_reference: KEGG COMPOUND:C07187
has_exact_synonym: Venlafaxine
database_cross_reference: Wikipedia:Venlafaxine
has_related_synonym: venlafaxina
has_related_synonym: venlafaxine
has_related_synonym: venlafaxinum
imported from: dron.owl

cell
type: Class
subclass of: material entity
definition: A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane.
database_cross_reference: CALOHA:TS-2035
id: CL:0000000
database_cross_reference: FMA:68646
database_cross_reference: GO:0005623
database_cross_reference: KUPO:0000002
comment: The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one).
database_cross_reference: VHOG:0001533
database_cross_reference: WBbt:0004017
database_cross_reference: XAO:0003012
has_obo_namespace: cell
imported from: oae.owl
imported from: uberon.owl
in_subset: upper level

native cell
type: Class
subclass of: cell
definition: A cell that is found in a natural setting, which includes multicellular organism cells 'in vivo' (i.e. part of an organism), and unicellular organisms 'in environment' (i.e. part of a natural environment).
database_cross_reference: CARO:0000013
id: CL:0000003
comment: To accommodate unicellular organisms better, 'cell in vivo' has been re-labeled 'native cell' to better represent its intended meaning - that is, that it is a cell in the context of a multicellular organism or in a natural environment. 'Native' is intended to contrast with 'in vitro', which refers to cells or other biological entities that have been intentionally placed in a controlled, non-natural setting for the purpose of study or manipulation. (MAH 1.12.12).
has_obo_namespace: cell
has_narrow_synonym: cell in vivo
imported from: oae.owl
imported from: uberon.owl
in_subset: upper level

neuronal receptor cell
type: Class
subclass of: sensory neuron
subclass of: receptor cell
id: CL:0000006
has_obo_namespace: cell
has_exact_synonym: neuronal receptor cell (sensu Animalia)
imported from: oae.owl
imported from: uberon.owl

neuroblast
type: Class
subclass of: neuronal stem cell
subclass of: non-terminally differentiated cell
definition: A cell that will develop into a neuron often after a migration phase.
database_cross_reference: BTO:0000930
id: CL:0000031
database_cross_reference: FBbt:00005146
database_cross_reference: FMA:70563
has_obo_namespace: cell
imported from: oae.owl
imported from: uberon.owl

stem cell
type: Class
subclass of: native cell
definition: A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
database_cross_reference: CALOHA:TS-2086
id: CL:0000034
database_cross_reference: FMA:63368
has_obo_namespace: cell
imported from: oae.owl
imported from: uberon.owl

neuronal stem cell
type: Class
subclass of: multi fate stem cell
subclass of: neural cell
subclass of: Restriction
  on property: develops_from
  some values from: neurectodermal cell
subclass of: Restriction
  on property: part_of
  some values from: central nervous system
database_cross_reference: BTO:0002881
database_cross_reference: CALOHA:TS-2360
id: CL:0000047
database_cross_reference: FMA:86684
has_exact_synonym: NSC
definition: Neural stem cell is characterized as an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors.
has_obo_namespace: cell
has_exact_synonym: neural stem cell
imported from: oae.owl
imported from: uberon.owl

multi fate stem cell
type: Class
subclass of: somatic stem cell
definition: A stem cell that can give rise to multiple lineages of cells.
id: CL:0000048
database_cross_reference: FMA:84789
has_obo_namespace: cell
has_exact_synonym: multi-fate stem cell
has_exact_synonym: multifate stem cell
has_exact_synonym: multipotent cell
has_exact_synonym: multipotent stem cell
imported from: oae.owl
imported from: uberon.owl

totipotent stem cell
type: Class
subclass of: somatic stem cell
definition: A stem cell from which all cells of the body can form.
id: CL:0000052
database_cross_reference: FMA:84790
has_obo_namespace: cell
has_exact_synonym: totipotential stem cell
imported from: oae.owl
imported from: uberon.owl

non-terminally differentiated cell
type: Class
subclass of: native cell
definition: A precursor cell with a limited number of potential fates.
database_cross_reference: BTO:0000125
id: CL:0000055
database_cross_reference: FMA:84782
has_exact_synonym: blast cell
has_obo_namespace: cell
comment: define using PATO mulit-potent or oligopotent?
imported from: oae.owl
imported from: uberon.owl

sensory neuron
type: Class
subclass of: afferent neuron
definition: Any neuron having a sensory function; an afferent neuron conveying sensory impulses.
database_cross_reference: BTO:0001037
id: CL:0000101
database_cross_reference: FBbt:00005124
database_cross_reference: FMA:84649
database_cross_reference: WBbt:0005759
has_obo_namespace: cell
imported from: oae.owl
imported from: uberon.owl

neurectodermal cell
type: Class
subclass of: ectodermal cell
id: CL:0000133
definition: Ectoderm destined to be nervous tissue.
has_obo_namespace: cell
has_exact_synonym: neurectoderm cell
imported from: oae.owl
imported from: uberon.owl

pigment cell
type: Class
subclass of: stuff accumulating cell
definition: A pigment cell is a cell that contains pigment granules.
id: CL:0000147
database_cross_reference: VHOG:0001678
has_obo_namespace: cell
has_exact_synonym: chromatocyte
has_exact_synonym: chromatophore
imported from: oae.owl
imported from: uberon.owl

visual pigment cell
type: Class
subclass of: pigment cell
id: CL:0000149
has_obo_namespace: cell
has_broad_synonym: pigment cell
imported from: oae.owl
imported from: uberon.owl

receptor cell
type: Class
subclass of: native cell
id: CL:0000197
has_obo_namespace: cell
imported from: oae.owl
imported from: uberon.owl

photoreceptor cell
type: Class
subclass of: neuronal receptor cell
definition: A cell specialized to detect and transduce light.
database_cross_reference: BTO:0001060
database_cross_reference: CALOHA:TS-0868
id: CL:0000210
database_cross_reference: FBbt:00004211
database_cross_reference: FMA:86740
has_obo_namespace: cell
imported from: oae.owl
imported from: uberon.owl

electrically active cell
type: Class
subclass of: native cell
definition: A cell whose function is determined by the generation or the reception of an electric signal.
id: CL:0000211
has_obo_namespace: cell
imported from: oae.owl
imported from: uberon.owl

ectodermal cell
type: Class
subclass of: embryonic cell
subclass of: Restriction
  on property: part_of
  some values from: ectoderm
definition: A cell of the outer of the three germ layers of the embryo.
id: CL:0000221
database_cross_reference: FMA:72549
has_obo_namespace: cell
has_exact_synonym: ectoderm cell
imported from: oae.owl
imported from: uberon.owl

eukaryotic cell
type: Class
subclass of: native cell
id: CL:0000255
has_obo_namespace: cell
imported from: oae.owl
imported from: uberon.owl

stuff accumulating cell
type: Class
subclass of: native cell
definition: A cell that is specialised to accumulate a particular substance(s).
id: CL:0000325
has_obo_namespace: cell
imported from: oae.owl
imported from: uberon.owl
in_subset: upper level

epiblast cell
type: Class
subclass of: totipotent stem cell
definition: A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation.
id: CL:0000352
has_obo_namespace: cell
imported from: oae.owl
imported from: uberon.owl

electrically responsive cell
type: Class
subclass of: electrically active cell
definition: A cell whose function is determined by its response to an electric signal.
id: CL:0000393
has_obo_namespace: cell
imported from: oae.owl
imported from: uberon.owl

electrically signaling cell
type: Class
subclass of: electrically active cell
definition: A cell that initiates an electrical signal and passes that signal to another cell.
id: CL:0000404
has_obo_namespace: cell
imported from: oae.owl
imported from: uberon.owl

afferent neuron
type: Class
subclass of: neuron
definition: A neuron which conveys sensory information centrally from the periphery.
id: CL:0000526
database_cross_reference: FMA:87653
has_obo_namespace: cell
has_exact_synonym: input neuron
imported from: oae.owl
imported from: uberon.owl

neuron
type: Class
subclass of: electrically responsive cell
subclass of: electrically signaling cell
subclass of: neural cell
subclass of: Restriction
  on property: develops_from
  some values from: neuroblast
database_cross_reference: BTO:0000938
database_cross_reference: CALOHA:TS-0683
id: CL:0000540
database_cross_reference: FBbt:00005106
database_cross_reference: FMA:54527
definition: The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
comment: These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma.
database_cross_reference: VHOG:0001483
database_cross_reference: WBbt:0003679
has_obo_namespace: cell
has_exact_synonym: nerve cell
imported from: oae.owl
imported from: uberon.owl

animal cell
type: Class
subclass of: eukaryotic cell
id: CL:0000548
has_obo_namespace: cell
imported from: oae.owl
imported from: uberon.owl
in_subset: upper level

somatic stem cell
type: Class
subclass of: stem cell
subclass of: somatic cell
definition: A stem cell that can give rise to cell types of the body other than those of the germ-line.
database_cross_reference: CALOHA:TS-2086
id: CL:0000723
database_cross_reference: FMA:63368
has_obo_namespace: cell
imported from: oae.owl
imported from: uberon.owl

neural cell
type: Class
subclass of: animal cell
subclass of: somatic cell
subclass of: Restriction
  on property: part_of
  some values from: nervous system
creation date: 2010-09-15T01:34:57Z
definition: A cell that is part of the nervous system.
database_cross_reference: CALOHA:TS-2040
id: CL:0002319
database_cross_reference: FMA:70333
has_obo_namespace: cell
created by: tmeehan
imported from: oae.owl
imported from: uberon.owl

embryonic cell
type: Class
subclass of: animal cell
creation date: 2010-09-15T03:39:21Z
definition: A cell of the embryo.
database_cross_reference: CALOHA:TS-0263
id: CL:0002321
database_cross_reference: FMA:82840
database_cross_reference: FMA:82841
database_cross_reference: WBbt:0007028
has_obo_namespace: cell
created by: tmeehan
imported from: oae.owl
imported from: uberon.owl

somatic cell
type: Class
subclass of: native cell
creation date: 2010-09-24T09:44:42Z
definition: A cell of an organism that does not pass on its genetic material to the organism's offspring (i.e. a non-germ line cell).
database_cross_reference: BTO:0001268
id: CL:0002371
database_cross_reference: FMA:72300
database_cross_reference: WBbt:0008378
has_obo_namespace: cell
created by: tmeehan
imported from: oae.owl
imported from: uberon.owl
in_subset: upper level

clinical drug role
type: Class
subclass of: role
term editor: William Hogan
creator: William Hogan
definition: the role of a material entity to prevent, diagnose, treat, or study disease and/or its effects
imported from: dron.owl

drug product
type: Class
subclass of: material entity
creator: William Hogan
term editor: William Hogan
definition: a material entity (1) containing at least one scattered molecular aggregate as part (the active ingredient) and (2) that is the bearer of a clinical drug role
imported from: dron.owl

Altretamine
type: Class
subclass of: processed material
has_RxCUI: 5296
imported from: dron.owl

capecitabine
type: Class
subclass of: processed material
has_RxCUI: 194000
imported from: dron.owl

Cerivastatin sodium
type: Class
subclass of: processed material
subclass of: Restriction
  on property: has participant
  some values from: Hydroxymethylglutaryl-CoA Reductase Inhibitors [MoA]
has_RxCUI: 221072
see also: NDF-RT: N0000022124
see also: RxNORM: RXNORM/221072
imported from: dron.owl

Delavirdine
type: Class
subclass of: processed material
subclass of: Restriction
  on property: has participant
  some values from: Reverse Transcriptase Inhibitors [MoA]
has_RxCUI: 83816
see also: NDF-RT: N0000022056
see also: RxNORM: RXNORM/83816
imported from: dron.owl

lomefloxacin
type: Class
subclass of: processed material
has_RxCUI: 28872
imported from: dron.owl

olsalazine
type: Class
subclass of: processed material
has_RxCUI: 32385
imported from: dron.owl

Penicillamine
type: Class
subclass of: processed material
has_RxCUI: 7975
imported from: dron.owl

Procarbazine
type: Class
subclass of: processed material
has_RxCUI: 8702
imported from: dron.owl

Succimer
type: Class
subclass of: processed material
has_RxCUI: 3446
imported from: dron.owl

tolcapone
type: Class
subclass of: processed material
has_RxCUI: 72937
imported from: dron.owl

Tolmetin
type: Class
subclass of: processed material
has_RxCUI: 10636
imported from: dron.owl

fluvastatin
type: Class
subclass of: processed material
has_RxCUI: 41127
imported from: dron.owl

infliximab
type: Class
subclass of: processed material
subclass of: Restriction
  on property: has participant
  some values from: Tumor Necrosis Factor alpha Receptor Blocking Activity [MoA]
has_RxCUI: 191831
see also: NDF-RT: N0000148580
see also: RxNORM: RXNORM/191831
imported from: dron.owl

Vigabatrin
type: Class
subclass of: processed material
has_RxCUI: 14851
imported from: dron.owl

Aldesleukin
type: Class
subclass of: processed material
has_RxCUI: 70223
imported from: dron.owl

Teniposide
type: Class
subclass of: processed material
has_RxCUI: 10362
imported from: dron.owl

basiliximab
type: Class
subclass of: processed material
subclass of: Restriction
  on property: has participant
  some values from: Interleukin 2 Receptor Antagonists [MoA]
has_RxCUI: 196102
see also: RxNORM: RXNORM/196102
see also: NDF-RT: N0000148568
imported from: dron.owl

trastuzumab
type: Class
subclass of: processed material
has_RxCUI: 224905
imported from: dron.owl

linezolid
type: Class
subclass of: processed material
has_RxCUI: 190376
imported from: dron.owl

arsenic trioxide
type: Class
subclass of: processed material
has_RxCUI: 18330
imported from: dron.owl

rituximab
type: Class
subclass of: processed material
has_RxCUI: 121191
imported from: dron.owl

Auranofin
type: Class
subclass of: processed material
has_RxCUI: 1227
imported from: dron.owl

Acitretin
type: Class
subclass of: processed material
has_RxCUI: 16818
imported from: dron.owl

Sirolimus
type: Class
subclass of: processed material
has_RxCUI: 35302
imported from: dron.owl

Carmustine
type: Class
subclass of: processed material
has_RxCUI: 2105
imported from: dron.owl

cevimeline
type: Class
subclass of: processed material
subclass of: Restriction
  on property: has participant
  some values from: Cholinergic Muscarinic Agonists [MoA]
has_RxCUI: 44281
see also: NDF-RT: N0000148658
see also: RxNORM: RXNORM/44281
imported from: dron.owl

Insulin, Protamine Zinc, Human
type: Class
subclass of: processed material
has_RxCUI: 236646
imported from: dron.owl

eletriptan
type: Class
subclass of: processed material
subclass of: Restriction
  on property: has role
  some values from: Serotonin Agonists [MoA]
has_RxCUI: 231049
see also: RxNORM: RXNORM/231049
see also: NDF-RT: N0000148791
imported from: dron.owl

mycophenolate mofetil
type: Class
subclass of: processed material
has_RxCUI: 68149
imported from: dron.owl

bexarotene
type: Class
subclass of: processed material
has_RxCUI: 233272
imported from: dron.owl

Zalcitabine
type: Class
subclass of: processed material
has_RxCUI: 3363
imported from: dron.owl

alosetron
type: Class
subclass of: processed material
subclass of: Restriction
  on property: has role
  some values from: Serotonin Antagonists [MoA]
has_RxCUI: 85248
imported from: dron.owl

enfuvirtide
type: Class
subclass of: processed material
subclass of: Restriction
  on property: has participant
  some values from: Viral Envelope Interactions [MoA]
has_RxCUI: 139896
see also: RxNORM: RXNORM/139896
see also: NDF-RT: N0000148793
imported from: dron.owl

zolmitriptan
type: Class
subclass of: processed material
has_RxCUI: 135775
imported from: dron.owl

gemifloxacin
type: Class
subclass of: processed material
subclass of: Restriction
  on property: has participant
  some values from: Topoisomerase Inhibitors [MoA]
has_RxCUI: 138099
see also: RxNORM: RXNORM/138099
see also: NDF-RT: N0000148804
imported from: dron.owl

Daptomycin
type: Class
subclass of: processed material
has_RxCUI: 22299
see also: RxNORM: RXNORM/22299
see also: NDF-RT: N0000148828
imported from: dron.owl

pemetrexed
type: Class
subclass of: processed material
has_RxCUI: 68446
imported from: dron.owl

Probenecid
type: Class
subclass of: processed material
has_RxCUI: 8698
imported from: dron.owl

Chlorambucil
type: Class
subclass of: processed material
subclass of: Restriction
  on property: has participant
  some values from: Alkylating Activity [MoA]
has_RxCUI: 2346
see also: NDF-RT: N0000147072
see also: RxNORM: RXNORM/2346
imported from: dron.owl

rofecoxib
type: Class
subclass of: processed material
has_RxCUI: 232158
imported from: dron.owl

Sulfamethizole
type: Class
subclass of: processed material
has_RxCUI: 10179
imported from: dron.owl

Thalidomide
type: Class
subclass of: processed material
has_RxCUI: 10432
imported from: dron.owl

Metolazone
type: Class
subclass of: processed material
has_RxCUI: 6916
imported from: dron.owl

Saquinavir
type: Class
subclass of: processed material
has_RxCUI: 83395
imported from: dron.owl

Flecainide
type: Class
subclass of: processed material
has_RxCUI: 4441
imported from: dron.owl

histrelin
type: Class
subclass of: processed material
has_RxCUI: 50975
imported from: dron.owl

rasagiline
type: Class
subclass of: processed material
has_RxCUI: 134748
imported from: dron.owl

gatifloxacin
type: Class
subclass of: processed material
has_RxCUI: 228476
imported from: dron.owl

Phenazopyridine
type: Class
subclass of: processed material
has_RxCUI: 8120
imported from: dron.owl

rivastigmine
type: Class
subclass of: processed material
has_RxCUI: 183379
imported from: dron.owl

Iopamidol
type: Class
subclass of: processed material
has_RxCUI: 5966
imported from: dron.owl

peginterferon alfa-2b
type: Class
subclass of: processed material
has_RxCUI: 253453
imported from: dron.owl

Triptorelin
type: Class
subclass of: processed material
has_RxCUI: 38782
imported from: dron.owl

fludarabine
type: Class
subclass of: processed material
has_RxCUI: 24698
imported from: dron.owl

efavirenz
type: Class
subclass of: processed material
has_RxCUI: 195085
imported from: dron.owl

pregabalin
type: Class
subclass of: processed material
has_RxCUI: 187832
imported from: dron.owl

Lamivudine
type: Class
subclass of: processed material
has_RxCUI: 68244
imported from: dron.owl

Memantine
type: Class
subclass of: processed material
has_RxCUI: 6719
imported from: dron.owl

gabapentin
type: Class
subclass of: processed material
has_RxCUI: 25480
imported from: dron.owl

Nevirapine
type: Class
subclass of: processed material
has_RxCUI: 53654
imported from: dron.owl

doxorubicin liposome
type: Class
subclass of: processed material
subclass of: Restriction
  on property: has participant
  some values from: Nucleic Acid Synthesis Inhibitors [MoA]
has_RxCUI: 214525
see also: NDF-RT: N0000147829
see also: RxNORM: RXNORM/3639
imported from: dron.owl

fluticasone
type: Class
subclass of: processed material
has_RxCUI: 41126
imported from: dron.owl

sildenafil
type: Class
subclass of: processed material
has_RxCUI: 136411
imported from: dron.owl

almotriptan
type: Class
subclass of: processed material
subclass of: Restriction
  on property: has role
  some values from: Serotonin Agonists [MoA]
has_RxCUI: 279645
see also: NDF-RT: N0000148709
see also: RxNORM: RXNORM/279645
imported from: dron.owl

valdecoxib
type: Class
subclass of: processed material
has_RxCUI: 278567
imported from: dron.owl

Miglustat
type: Class
subclass of: processed material
has_RxCUI: 402316
imported from: dron.owl

Atazanavir
type: Class
subclass of: processed material
subclass of: Restriction
  on property: has participant
  some values from: HIV Protease Inhibitors [MoA]
has_RxCUI: 343047
see also: RxNORM: RXNORM/343047
see also: NDF-RT: N0000022320
imported from: dron.owl

bortezomib
type: Class
subclass of: processed material
has_RxCUI: 358258
imported from: dron.owl

tadalafil
type: Class
subclass of: processed material
has_RxCUI: 358263
imported from: dron.owl

aprepitant
type: Class
subclass of: processed material
subclass of: Restriction
  on property: has participant
  some values from: Neurokinin 1 Antagonists [MoA]
has_RxCUI: 358255
see also: NDF-RT: N0000148809
see also: RxNORM: RXNORM/358255
imported from: dron.owl

imatinib
type: Class
subclass of: processed material
has_RxCUI: 282388
imported from: dron.owl

erlotinib
type: Class
subclass of: processed material
subclass of: Restriction
  on property: has participant
  some values from: HER1 Antagonists [MoA]
has_RxCUI: 337525
see also: NDF-RT: N0000148872
see also: RxNORM: RXNORM/337525
imported from: dron.owl

Eszopiclone
type: Class
subclass of: processed material
has_RxCUI: 461016
see also: RxNORM: RXNORM/461016
see also: NDF-RT: N0000023088
imported from: dron.owl

sorafenib
type: Class
subclass of: processed material
has_RxCUI: 495881
imported from: dron.owl

lenalidomide
type: Class
subclass of: processed material
has_RxCUI: 342369
see also: NDF-RT: N0000171749
see also: RxNORM: RXNORM/342369
imported from: dron.owl

nelarabine
type: Class
subclass of: processed material
has_RxCUI: 274771
imported from: dron.owl

Nalidixate
type: Class
subclass of: processed material
has_RxCUI: 618425
imported from: dron.owl

dasatinib
type: Class
subclass of: processed material
has_RxCUI: 475342
see also: NDF-RT: N0000176043
see also: RxNORM: RXNORM/475342
imported from: dron.owl

posaconazole
type: Class
subclass of: processed material
has_RxCUI: 282446
imported from: dron.owl

maraviroc
type: Class
subclass of: processed material
has_RxCUI: 620216
see also: NDF-RT: N0000176115
see also: RxNORM: RXNORM/620216
imported from: dron.owl

ixabepilone
type: Class
subclass of: processed material
has_RxCUI: 337523
see also: NDF-RT: N0000176119
see also: RxNORM: RXNORM/337523
imported from: dron.owl

nilotinib
type: Class
subclass of: processed material
has_RxCUI: 662281
imported from: dron.owl

etravirine
type: Class
subclass of: processed material
has_RxCUI: 475969
see also: NDF-RT: N0000176133
see also: RxNORM: RXNORM/475969
imported from: dron.owl

Fosaprepitant dimeglumine
type: Class
subclass of: processed material
has_RxCUI: 754763
see also: RxNORM: RXNORM/754763
see also: NDF-RT: N0000176136
imported from: dron.owl

golimumab
type: Class
subclass of: processed material
has_RxCUI: 819300
see also: NDF-RT: N0000178413
see also: RxNORM: RXNORM/819300
imported from: dron.owl

certolizumab pegol
type: Class
subclass of: processed material
has_RxCUI: 709271
imported from: dron.owl

valganciclovir
type: Class
subclass of: processed material
has_RxCUI: 275891
imported from: dron.owl

levoleucovorin
type: Class
subclass of: processed material
has_RxCUI: 877015
see also: NDF-RT: N0000177954
see also: RxNORM: RXNORM/877015
imported from: dron.owl

telbivudine
type: Class
subclass of: processed material
has_RxCUI: 474128
imported from: dron.owl

tocilizumab
type: Class
subclass of: processed material
has_RxCUI: 612865
imported from: dron.owl

Cytarabine liposome
type: Class
subclass of: processed material
subclass of: Restriction
  on property: has participant
  some values from: Nucleic Acid Synthesis Inhibitors [MoA]
has_RxCUI: 968804
see also: NDF-RT: N0000146419
see also: RxNORM: RXNORM/3041
imported from: dron.owl

cabazitaxel
type: Class
subclass of: processed material
has_RxCUI: 996051
see also: NDF-RT: N0000181529
see also: RxNORM: RXNORM/996051
imported from: dron.owl

tesamorelin
type: Class
subclass of: processed material
has_RxCUI: 1044584
imported from: dron.owl

eribulin
type: Class
subclass of: processed material
has_RxCUI: 1045453
see also: RxNORM: RXNORM/1045453
see also: NDF-RT: N0000182260
imported from: dron.owl

ipilimumab
type: Class
subclass of: processed material
has_RxCUI: 1094833
see also: NDF-RT: N0000182641
see also: RxNORM: RXNORM/1094833
imported from: dron.owl

Vemurafenib
type: Class
subclass of: processed material
has_RxCUI: 1147220
imported from: dron.owl

crizotinib
type: Class
subclass of: processed material
has_RxCUI: 1148495
see also: NDF-RT: N0000183253
see also: RxNORM: RXNORM/1148495
imported from: dron.owl

avanafil
type: Class
subclass of: processed material
has_RxCUI: 1291301
imported from: dron.owl

carfilzomib
type: Class
subclass of: processed material
has_RxCUI: 1302966
imported from: dron.owl

emtricitabine
type: Class
subclass of: processed material
has_RxCUI: 276237
imported from: dron.owl

tenofovir disoproxil
type: Class
subclass of: processed material
has_RxCUI: 300195
imported from: dron.owl

teriflunomide
type: Class
subclass of: processed material
has_RxCUI: 1310520
imported from: dron.owl

non-activating competitive beta-adrenergic receptor binding disposition
type: Class
subclass of: disposition
imported from: dron.owl

function-inhibiting hydrogen/potassium adenosine triphosphatase enzyme (H+/K+ ATPase) binding disposition
type: Class
subclass of: disposition
imported from: dron.owl

function-inhibiting L-type voltage-gated calcium channel binding disposition
type: Class
subclass of: disposition
imported from: dron.owl

Triamcinolone Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Glucocorticoid Receptor Agonists [MoA]
subclass of: Restriction
  on property: has participant
  some values from: Lipoxygenase Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Triamcinolone
has_RxCUI: 96819
see also: RxNORM: RXNORM/10759
see also: NDF-RT: N0000145980
imported from: dron.owl

Dexamethasone Ophthalmic Ointment
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Dexamethasone
subclass of: Restriction
  on property: has participant
  some values from: Glucocorticoid Receptor Agonists [MoA]
subclass of: Restriction
  on property: has participant
  some values from: Lipoxygenase Inhibitors [MoA]
has_RxCUI: 103217
see also: NDF-RT: N0000146273
see also: RxNORM: RXNORM/3264
imported from: dron.owl

Hydrocortisone Ophthalmic Ointment
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Hydrocortisone
has_RxCUI: 108133
imported from: dron.owl

Colchicine / Probenecid Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Colchicine
subclass of: Restriction
  on property: has participant
  some values from: Tubulin Interactions [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Probenecid
has_RxCUI: 239053
see also: RxNORM: RXNORM/2683
see also: NDF-RT: N0000145804
imported from: dron.owl

fluticasone Inhalant Powder
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: fluticasone
has_RxCUI: 361834
imported from: dron.owl

Carmustine Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Carmustine
subclass of: Restriction
  on property: has participant
  some values from: Alkylating Activity [MoA]
has_RxCUI: 370496
see also: NDF-RT: N0000146473
see also: RxNORM: RXNORM/2105
imported from: dron.owl

Acitretin Oral Capsule
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Acitretin
has_RxCUI: 370533
see also: NDF-RT: N0000148524
see also: RxNORM: RXNORM/16818
imported from: dron.owl

Allopurinol Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Xanthine Oxidase Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Allopurinol
has_RxCUI: 370547
see also: RxNORM: RXNORM/519
see also: NDF-RT: N0000146247
imported from: dron.owl

Amantadine Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Ion Channel Interactions [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Amantadine
subclass of: Restriction
  on property: has participant
  some values from: Dopamine Receptor Interactions [MoA]
has_RxCUI: 370559
see also: NDF-RT: N0000147697
see also: RxNORM: RXNORM/620
imported from: dron.owl

Amiodarone Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Potassium Channel Interactions [MoA]
subclass of: Restriction
  on property: has participant
  some values from: Calcium Channel Antagonists [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Amiodarone
subclass of: Restriction
  on property: has participant
  some values from: Adrenergic beta-Antagonists [MoA]
subclass of: Restriction
  on property: has participant
  some values from: Sodium Channel Interactions [MoA]
has_RxCUI: 370568
see also: NDF-RT: N0000147701
see also: RxNORM: RXNORM/203114
see also: RxNORM: RXNORM/703
see also: NDF-RT: N0000146406
imported from: dron.owl

Amitriptyline Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Serotonin Uptake Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Amitriptyline
subclass of: Restriction
  on property: has participant
  some values from: Norepinephrine Uptake Inhibitors [MoA]
has_RxCUI: 370570
see also: NDF-RT: N0000023131
see also: RxNORM: RXNORM/203168
imported from: dron.owl

Amlodipine Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: L-Calcium Channel Receptor Antagonists [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Amlodipine
has_RxCUI: 370573
see also: NDF-RT: N0000148333
see also: RxNORM: RXNORM/17767
imported from: dron.owl

anastrozole Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: anastrozole
subclass of: Restriction
  on property: has participant
  some values from: Enzyme Inhibitors [MoA]
has_RxCUI: 370588
see also: NDF-RT: N0000148427
see also: RxNORM: RXNORM/84857
imported from: dron.owl

Aspirin Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Aspirin
has_RxCUI: 370611
imported from: dron.owl

atorvastatin Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Hydroxymethylglutaryl-CoA Reductase Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: atorvastatin
has_RxCUI: 370621
see also: NDF-RT: N0000022046
see also: RxNORM: RXNORM/83367
imported from: dron.owl

hydroxyurea Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Ribonucleotide Reductase Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: hydroxyurea
has_RxCUI: 370657
see also: NDF-RT: N0000146101
see also: RxNORM: RXNORM/5552
imported from: dron.owl

Imipramine Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Norepinephrine Uptake Inhibitors [MoA]
subclass of: Restriction
  on property: has participant
  some values from: Serotonin Uptake Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Imipramine
has_RxCUI: 370679
see also: NDF-RT: N0000147875
see also: NDF-RT: N0000146215
see also: RxNORM: RXNORM/5691
see also: RxNORM: RXNORM/150816
imported from: dron.owl

Imipramine Oral Capsule
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Serotonin Uptake Inhibitors [MoA]
subclass of: Restriction
  on property: has participant
  some values from: Norepinephrine Uptake Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Imipramine
has_RxCUI: 370680
see also: NDF-RT: N0000146216
see also: RxNORM: RXNORM/91118
imported from: dron.owl

Indomethacin Oral Suspension
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Cyclooxygenase Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Indomethacin
has_RxCUI: 370686
see also: NDF-RT: N0000146243
see also: RxNORM: RXNORM/5781
imported from: dron.owl

Iopamidol Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Iopamidol
subclass of: Restriction
  on property: has participant
  some values from: Radiopharmaceutical Activity [MoA]
has_RxCUI: 370700
see also: NDF-RT: N0000146122
see also: RxNORM: RXNORM/5966
imported from: dron.owl

isoniazid Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: isoniazid
has_RxCUI: 370716
see also: NDF-RT: N0000145890
see also: RxNORM: RXNORM/6038
imported from: dron.owl

Itraconazole Oral Capsule
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Itraconazole
subclass of: Restriction
  on property: has participant
  some values from: 14-alpha Demethylase Inhibitors [MoA]
has_RxCUI: 370725
see also: NDF-RT: N0000148264
see also: RxNORM: RXNORM/28031
imported from: dron.owl

Altretamine Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Alkylating Activity [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Altretamine
subclass of: Restriction
  on property: has participant
  some values from: Nucleic Acid Synthesis Inhibitors [MoA]
has_RxCUI: 370819
see also: RxNORM: RXNORM/5296
see also: NDF-RT: N0000147673
imported from: dron.owl

Auranofin Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Auranofin
has_RxCUI: 370967
see also: RxNORM: RXNORM/1227
see also: NDF-RT: N0000146358
imported from: dron.owl

Betaxolol Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Betaxolol
subclass of: Restriction
  on property: has participant
  some values from: Adrenergic beta1-Antagonists [MoA]
has_RxCUI: 371065
see also: NDF-RT: N0000147726
see also: RxNORM: RXNORM/1520
imported from: dron.owl

bicalutamide Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Androgen Receptor Antagonists [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: bicalutamide
has_RxCUI: 371070
see also: RxNORM: RXNORM/83008
see also: NDF-RT: N0000148428
imported from: dron.owl

Bromocriptine Oral Capsule
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Bromocriptine
has_RxCUI: 371127
imported from: dron.owl

Buspirone Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Buspirone
has_RxCUI: 371164
imported from: dron.owl

Caffeine Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Caffeine
has_RxCUI: 371181
imported from: dron.owl

capecitabine Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: capecitabine
subclass of: Restriction
  on property: has participant
  some values from: Thymidylate Synthetase Inhibitors [MoA]
has_RxCUI: 371250
see also: RxNORM: RXNORM/996051
see also: NDF-RT: N0000148555
imported from: dron.owl

Capsaicin Topical Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Neurotransmitter Transporter Interactions [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Capsaicin
has_RxCUI: 371251
see also: RxNORM: RXNORM/1992
see also: NDF-RT: N0000147626
imported from: dron.owl

Ciprofloxacin Oral Capsule
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Topoisomerase Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Ciprofloxacin
has_RxCUI: 371523
see also: NDF-RT: N0000147503
see also: RxNORM: RXNORM/2551
imported from: dron.owl

Ciprofloxacin Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Topoisomerase Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Ciprofloxacin
has_RxCUI: 371525
see also: RxNORM: RXNORM/81981
see also: NDF-RT: N0000147502
imported from: dron.owl

Clomipramine Oral Capsule
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Norepinephrine Uptake Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Clomipramine
subclass of: Restriction
  on property: has participant
  some values from: Serotonin Uptake Inhibitors [MoA]
has_RxCUI: 371572
see also: RxNORM: RXNORM/2597
see also: NDF-RT: N0000147779
imported from: dron.owl

Codeine Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Codeine
has_RxCUI: 371613
imported from: dron.owl

cyclobenzaprine Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: cyclobenzaprine
has_RxCUI: 371661
see also: RxNORM: RXNORM/21949
see also: NDF-RT: N0000147791
imported from: dron.owl

Cyclosporine Oral Capsule
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Cyclosporine
has_RxCUI: 371666
see also: NDF-RT: N0000147064
see also: RxNORM: RXNORM/3008
imported from: dron.owl

Dapsone Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Para-Aminobenzoic Acid Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Dapsone
has_RxCUI: 371689
see also: RxNORM: RXNORM/3108
see also: NDF-RT: N0000147467
imported from: dron.owl

Desipramine Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Desipramine
subclass of: Restriction
  on property: has participant
  some values from: Norepinephrine Uptake Inhibitors [MoA]
subclass of: Restriction
  on property: has participant
  some values from: Serotonin Uptake Inhibitors [MoA]
has_RxCUI: 371709
see also: NDF-RT: N0000147800
see also: RxNORM: RXNORM/3247
imported from: dron.owl

Didanosine Chewable Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Didanosine
subclass of: Restriction
  on property: has participant
  some values from: Reverse Transcriptase Inhibitors [MoA]
has_RxCUI: 371819
see also: RxNORM: RXNORM/3364
see also: NDF-RT: N0000148104
imported from: dron.owl

Diltiazem Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Diltiazem
subclass of: Restriction
  on property: has participant
  some values from: L-Calcium Channel Receptor Antagonists [MoA]
has_RxCUI: 371856
see also: NDF-RT: N0000147814
see also: RxNORM: RXNORM/3443
imported from: dron.owl

Disulfiram Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Disulfiram
subclass of: Restriction
  on property: has participant
  some values from: Acetyl Aldehyde Dehydrogenase Inhibitors [MoA]
has_RxCUI: 371940
see also: NDF-RT: N0000146816
see also: RxNORM: RXNORM/3554
imported from: dron.owl

efavirenz Oral Capsule
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: efavirenz
subclass of: Restriction
  on property: has participant
  some values from: Reverse Transcriptase Inhibitors [MoA]
has_RxCUI: 372003
see also: NDF-RT: N0000148587
see also: RxNORM: RXNORM/195085
imported from: dron.owl

Enalapril Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Enalapril
has_RxCUI: 372007
imported from: dron.owl

Ethambutol Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Ethambutol
subclass of: Restriction
  on property: has participant
  some values from: Nucleic Acid Synthesis Inhibitors [MoA]
has_RxCUI: 372091
see also: NDF-RT: N0000147838
see also: NDF-RT: N0000146263
see also: RxNORM: RXNORM/142435
see also: RxNORM: RXNORM/4110
imported from: dron.owl

Etidronate Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Bone Surface Interactions [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Etidronate
has_RxCUI: 372120
see also: RxNORM: RXNORM/42682
see also: NDF-RT: N0000147844
imported from: dron.owl

Etoposide Oral Capsule
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Etoposide
subclass of: Restriction
  on property: has participant
  some values from: Nucleic Acid Synthesis Inhibitors [MoA]
has_RxCUI: 372132
see also: NDF-RT: N0000146478
see also: RxNORM: RXNORM/4179
imported from: dron.owl

Fentanyl Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Fentanyl
subclass of: Restriction
  on property: has participant
  some values from: Opioid Agonists [MoA]
has_RxCUI: 372160
see also: RxNORM: RXNORM/4337
see also: NDF-RT: N0000147049
imported from: dron.owl

Fluconazole Oral Capsule
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Fluconazole
subclass of: Restriction
  on property: has participant
  some values from: 14-alpha Demethylase Inhibitors [MoA]
has_RxCUI: 372208
see also: RxNORM: RXNORM/4450
see also: NDF-RT: N0000147613
imported from: dron.owl

Flucytosine Oral Capsule
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Flucytosine
subclass of: Restriction
  on property: has participant
  some values from: Protein Synthesis Inhibitors [MoA]
has_RxCUI: 372211
see also: NDF-RT: N0000146153
see also: RxNORM: RXNORM/4451
imported from: dron.owl

Fluorouracil Oral Capsule
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Thymidylate Synthetase Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: 5-fluorouracil
has_RxCUI: 372227
see also: RxNORM: RXNORM/4492
see also: NDF-RT: N0000146166
imported from: dron.owl

Fluoxetine Oral Capsule
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Fluoxetine
has_RxCUI: 372231
imported from: dron.owl

fluvastatin Oral Capsule
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: fluvastatin
subclass of: Restriction
  on property: has participant
  some values from: Hydroxymethylglutaryl-CoA Reductase Inhibitors [MoA]
has_RxCUI: 372255
see also: NDF-RT: N0000021914
see also: RxNORM: RXNORM/41127
imported from: dron.owl

Fluvoxamine Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Serotonin Uptake Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Fluvoxamine
has_RxCUI: 372256
see also: RxNORM: RXNORM/203143
see also: NDF-RT: N0000148386
imported from: dron.owl

Ganciclovir Oral Capsule
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Ganciclovir
subclass of: Restriction
  on property: has participant
  some values from: Nucleic Acid Synthesis Inhibitors [MoA]
has_RxCUI: 372292
see also: NDF-RT: N0000147855
see also: RxNORM: RXNORM/4678
imported from: dron.owl

Gentamicin Sulfate (USP) Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Gentamicin Sulfate (USP)
has_RxCUI: 372302
imported from: dron.owl

Haloperidol Oral Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Dopamine Antagonists [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Haloperidol
has_RxCUI: 372376
see also: RxNORM: RXNORM/5093
see also: NDF-RT: N0000146461
imported from: dron.owl

Lamivudine Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Reverse Transcriptase Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Lamivudine
has_RxCUI: 372563
see also: RxNORM: RXNORM/68244
see also: NDF-RT: N0000148418
imported from: dron.owl

leflunomide Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: leflunomide
subclass of: Restriction
  on property: has participant
  some values from: Nucleic Acid Synthesis Inhibitors [MoA]
has_RxCUI: 372570
see also: RxNORM: RXNORM/27169
see also: NDF-RT: N0000148586
imported from: dron.owl

Leuprolide Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Leuprolide
has_RxCUI: 372576
imported from: dron.owl

Levodopa Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: L-dopa
has_RxCUI: 372586
imported from: dron.owl

Levofloxacin Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Topoisomerase Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Levofloxacin
has_RxCUI: 372588
see also: NDF-RT: N0000148474
see also: RxNORM: RXNORM/82122
imported from: dron.owl

Lisinopril Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Lisinopril
subclass of: Restriction
  on property: has participant
  some values from: Angiotensin-converting Enzyme Inhibitors [MoA]
has_RxCUI: 372614
see also: RxNORM: RXNORM/29046
see also: NDF-RT: N0000147537
imported from: dron.owl

lomefloxacin Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: lomefloxacin
subclass of: Restriction
  on property: has participant
  some values from: Topoisomerase Inhibitors [MoA]
has_RxCUI: 372630
see also: NDF-RT: N0000148144
see also: RxNORM: RXNORM/235762
see also: NDF-RT: N0000148250
see also: RxNORM: RXNORM/28872
imported from: dron.owl

Losartan Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Angiotensin 2 Receptor Antagonists [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Losartan
has_RxCUI: 372651
see also: RxNORM: RXNORM/203160
see also: NDF-RT: N0000148401
see also: RxNORM: RXNORM/52175
see also: NDF-RT: N0000148405
imported from: dron.owl

Lovastatin Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Lovastatin
subclass of: Restriction
  on property: has participant
  some values from: Hydroxymethylglutaryl-CoA Reductase Inhibitors [MoA]
has_RxCUI: 372652
see also: RxNORM: RXNORM/6472
see also: NDF-RT: N0000147602
imported from: dron.owl

Mefloquine Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Mefloquine
has_RxCUI: 372745
see also: NDF-RT: N0000147900
see also: RxNORM: RXNORM/6694
imported from: dron.owl

Megestrol Oral Suspension
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Megestrol
subclass of: Restriction
  on property: has participant
  some values from: Progestational Hormone Receptor Agonists [MoA]
subclass of: Restriction
  on property: has participant
  some values from: Estrogen Receptor Antagonists [MoA]
has_RxCUI: 372747
see also: RxNORM: RXNORM/6703
see also: NDF-RT: N0000020211
imported from: dron.owl

Memantine Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Memantine
has_RxCUI: 372757
imported from: dron.owl

mesalamine Extended Release Capsule
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: mesalamine
has_RxCUI: 372783
see also: RxNORM: RXNORM/52582
see also: NDF-RT: N0000147614
imported from: dron.owl

Metformin Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Metformin
has_RxCUI: 372803
imported from: dron.owl

Methimazole Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Organic Anion Transporter Interactions [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Methimazole
subclass of: Restriction
  on property: has participant
  some values from: Protein Synthesis Inhibitors [MoA]
subclass of: Restriction
  on property: has participant
  some values from: Uncouplers [MoA]
has_RxCUI: 372827
see also: RxNORM: RXNORM/6835
see also: NDF-RT: N0000145822
imported from: dron.owl

Methotrexate Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Dihydrofolate Reductase Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Methotrexate
subclass of: Restriction
  on property: has participant
  some values from: Thymidylate Synthetase Inhibitors [MoA]
has_RxCUI: 372835
see also: NDF-RT: N0000147916
see also: RxNORM: RXNORM/6851
imported from: dron.owl

Methylprednisolone Topical Ointment
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Lipoxygenase Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: 6alpha-methylprednisolone
subclass of: Restriction
  on property: has participant
  some values from: Glucocorticoid Receptor Agonists [MoA]
has_RxCUI: 372863
see also: RxNORM: RXNORM/52582
see also: NDF-RT: N0000146409
imported from: dron.owl

Methylprednisolone Injectable Suspension
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Glucocorticoid Receptor Agonists [MoA]
subclass of: Restriction
  on property: has participant
  some values from: Lipoxygenase Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: 6alpha-methylprednisolone
has_RxCUI: 372866
see also: RxNORM: RXNORM/155323
see also: NDF-RT: N0000146411
imported from: dron.owl

Metolazone Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Metolazone
subclass of: Restriction
  on property: has participant
  some values from: Small Ion Transport Pump Interactions [MoA]
has_RxCUI: 372888
see also: RxNORM: RXNORM/6916
see also: NDF-RT: N0000146498
imported from: dron.owl

Metronidazole Oral Suspension
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Metronidazole
has_RxCUI: 372893
see also: RxNORM: RXNORM/6922
see also: NDF-RT: N0000146194
imported from: dron.owl

Misoprostol Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Misoprostol
has_RxCUI: 372941
see also: NDF-RT: N0000147506
see also: RxNORM: RXNORM/42331
imported from: dron.owl

Nevirapine Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Nevirapine
subclass of: Restriction
  on property: has participant
  some values from: Reverse Transcriptase Inhibitors [MoA]
has_RxCUI: 373046
see also: RxNORM: RXNORM/53654
see also: NDF-RT: N0000148461
imported from: dron.owl

Nitrofurantoin Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Nitrofurantoin
subclass of: Restriction
  on property: has participant
  some values from: Enzyme Inhibitors [MoA]
has_RxCUI: 373101
see also: RxNORM: RXNORM/7454
see also: NDF-RT: N0000147151
imported from: dron.owl

Norfloxacin Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Norfloxacin
subclass of: Restriction
  on property: has participant
  some values from: Topoisomerase Inhibitors [MoA]
has_RxCUI: 373120
see also: RxNORM: RXNORM/7517
see also: NDF-RT: N0000147623
imported from: dron.owl

Nortriptyline Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Serotonin Uptake Inhibitors [MoA]
subclass of: Restriction
  on property: has participant
  some values from: Norepinephrine Uptake Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Nortriptyline
has_RxCUI: 373126
see also: NDF-RT: N0000147946
see also: RxNORM: RXNORM/7531
imported from: dron.owl

Ofloxacin Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Ofloxacin
subclass of: Restriction
  on property: has participant
  some values from: Topoisomerase Inhibitors [MoA]
has_RxCUI: 373141
see also: RxNORM: RXNORM/7623
see also: NDF-RT: N0000147667
imported from: dron.owl

olsalazine Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: olsalazine
subclass of: Restriction
  on property: has participant
  some values from: Cyclooxygenase Inhibitors [MoA]
has_RxCUI: 373144
see also: NDF-RT: N0000147671
see also: RxNORM: RXNORM/104123
imported from: dron.owl

pantoprazole Enteric Coated Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: pantoprazole
subclass of: Restriction
  on property: has participant
  some values from: Proton Pump Inhibitors [MoA]
has_RxCUI: 373222
see also: RxNORM: RXNORM/40790
see also: NDF-RT: N0000148654
imported from: dron.owl

Penicillamine Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Chelating Activity [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Penicillamine
has_RxCUI: 373258
see also: NDF-RT: N0000146290
see also: RxNORM: RXNORM/7975
imported from: dron.owl

Penicillin G Oral Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Penicillin G
has_RxCUI: 373263
imported from: dron.owl

Penicillin V Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Transpeptidase Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Penicillin V
has_RxCUI: 373266
see also: RxNORM: RXNORM/203195
see also: NDF-RT: N0000145824
imported from: dron.owl

Pergolide Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Dopamine Agonists [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Pergolide
has_RxCUI: 373291
see also: RxNORM: RXNORM/8047
see also: NDF-RT: N0000147968
imported from: dron.owl

Phenazopyridine Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Phenazopyridine
has_RxCUI: 373303
imported from: dron.owl

Phenytoin Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Phenytoin
subclass of: Restriction
  on property: has participant
  some values from: Sodium Channel Interactions [MoA]
has_RxCUI: 373432
see also: RxNORM: RXNORM/8183
see also: NDF-RT: N0000146211
imported from: dron.owl

Pravastatin Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Pravastatin
subclass of: Restriction
  on property: has participant
  some values from: Hydroxymethylglutaryl-CoA Reductase Inhibitors [MoA]
has_RxCUI: 373560
see also: RxNORM: RXNORM/42463
see also: NDF-RT: N0000148255
imported from: dron.owl

prednisolone Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: prednisolone
has_RxCUI: 373578
imported from: dron.owl

Procarbazine Oral Capsule
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Procarbazine
has_RxCUI: 373602
imported from: dron.owl

Propafenone Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Propafenone
has_RxCUI: 373637
imported from: dron.owl

Propylthiouracil Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Protein Synthesis Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: 6-propyl-2-thiouracil
subclass of: Restriction
  on property: has participant
  some values from: Organic Anion Transporter Interactions [MoA]
subclass of: Restriction
  on property: has participant
  some values from: Uncouplers [MoA]
has_RxCUI: 373658
see also: NDF-RT: N0000145820
see also: RxNORM: RXNORM/8794
imported from: dron.owl

Protriptyline Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Serotonin Uptake Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Protriptyline
subclass of: Restriction
  on property: has participant
  some values from: Norepinephrine Uptake Inhibitors [MoA]
has_RxCUI: 373665
see also: RxNORM: RXNORM/8886
see also: NDF-RT: N0000148003
imported from: dron.owl

Ramipril Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Angiotensin-converting Enzyme Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Ramipril
has_RxCUI: 373749
see also: RxNORM: RXNORM/35296
see also: NDF-RT: N0000147662
imported from: dron.owl

Ribavirin Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Ribavirin
has_RxCUI: 373774
imported from: dron.owl

rivastigmine Oral Capsule
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: rivastigmine
subclass of: Restriction
  on property: has participant
  some values from: Cholinesterase Inhibitors [MoA]
has_RxCUI: 373797
see also: RxNORM: RXNORM/183379
see also: NDF-RT: N0000148665
imported from: dron.owl

ropinirole Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Dopamine Agonists [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: ropinirole
has_RxCUI: 373800
see also: NDF-RT: N0000022086
see also: RxNORM: RXNORM/72302
imported from: dron.owl

Selegiline Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Selegiline
subclass of: Restriction
  on property: has participant
  some values from: Monoamine Oxidase Inhibitors [MoA]
has_RxCUI: 373842
see also: NDF-RT: N0000148014
see also: RxNORM: RXNORM/9639
imported from: dron.owl

sildenafil Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: sildenafil
subclass of: Restriction
  on property: has participant
  some values from: Phosphodiesterase 5 Inhibitors [MoA]
has_RxCUI: 373871
see also: NDF-RT: N0000022115
see also: RxNORM: RXNORM/136411
imported from: dron.owl

Simvastatin Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Hydroxymethylglutaryl-CoA Reductase Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Simvastatin
has_RxCUI: 373888
see also: NDF-RT: N0000148200
see also: RxNORM: RXNORM/36567
imported from: dron.owl

Sotalol Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Sotalol
subclass of: Restriction
  on property: has participant
  some values from: Adrenergic beta2-Antagonists [MoA]
subclass of: Restriction
  on property: has participant
  some values from: Adrenergic beta1-Antagonists [MoA]
has_RxCUI: 373937
see also: NDF-RT: N0000148322
see also: RxNORM: RXNORM/7008
see also: RxNORM: RXNORM/9947
see also: NDF-RT: N0000148334
imported from: dron.owl

Stavudine Oral Capsule
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Stavudine
subclass of: Restriction
  on property: has participant
  some values from: Reverse Transcriptase Inhibitors [MoA]
has_RxCUI: 373959
see also: RxNORM: RXNORM/59763
see also: NDF-RT: N0000148369
imported from: dron.owl

Succimer Oral Capsule
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Succimer
subclass of: Restriction
  on property: has participant
  some values from: Chelating Activity [MoA]
has_RxCUI: 373964
see also: RxNORM: RXNORM/3446
see also: NDF-RT: N0000147417
imported from: dron.owl

Sulfamethizole Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Para-Aminobenzoic Acid Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Sulfamethizole
has_RxCUI: 373981
see also: NDF-RT: N0000146815
imported from: dron.owl

Sulfasalazine Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Sulfasalazine
subclass of: Restriction
  on property: has participant
  some values from: Cyclooxygenase Inhibitors [MoA]
has_RxCUI: 373991
see also: NDF-RT: N0000146249
see also: RxNORM: RXNORM/9524
imported from: dron.owl

Sumatriptan Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has role
  some values from: Serotonin Agonists [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Sumatriptan
has_RxCUI: 374012
imported from: dron.owl

Tamoxifen Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Selective Estrogen Receptor Modulators [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Tamoxifen
has_RxCUI: 374020
see also: NDF-RT: N0000148024
see also: RxNORM: RXNORM/10324
imported from: dron.owl

Ticlopidine Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Ticlopidine
has_RxCUI: 374131
see also: NDF-RT: N0000148235
see also: RxNORM: RXNORM/10594
imported from: dron.owl

Tinidazole Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Tinidazole
has_RxCUI: 374138
see also: RxNORM: RXNORM/10612
see also: NDF-RT: N0000148851
imported from: dron.owl

tizanidine Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: tizanidine
subclass of: Restriction
  on property: has participant
  some values from: Adrenergic alpha2-Agonists [MoA]
has_RxCUI: 374146
see also: NDF-RT: N0000148492
see also: RxNORM: RXNORM/57258
imported from: dron.owl

Tobramycin Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Tobramycin
has_RxCUI: 374147
imported from: dron.owl

tolcapone Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: tolcapone
subclass of: Restriction
  on property: has participant
  some values from: Enzyme Inhibitors [MoA]
has_RxCUI: 374153
see also: RxNORM: RXNORM/72937
see also: NDF-RT: N0000148551
imported from: dron.owl

Tolmetin Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Cyclooxygenase Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Tolmetin
has_RxCUI: 374157
see also: RxNORM: RXNORM/10636
see also: NDF-RT: N0000148037
imported from: dron.owl

topiramate Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Sodium Channel Interactions [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: topiramate
has_RxCUI: 374166
see also: NDF-RT: N0000148493
see also: RxNORM: RXNORM/38404
imported from: dron.owl

Trimipramine Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Serotonin Uptake Inhibitors [MoA]
subclass of: Restriction
  on property: has participant
  some values from: Norepinephrine Uptake Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Trimipramine
has_RxCUI: 374239
see also: NDF-RT: N0000148047
see also: RxNORM: RXNORM/10834
imported from: dron.owl

venlafaxine Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Norepinephrine Uptake Inhibitors [MoA]
subclass of: Restriction
  on property: has participant
  some values from: Serotonin Uptake Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: venlafaxine
has_RxCUI: 374285
see also: NDF-RT: N0000021906
see also: RxNORM: RXNORM/39786
imported from: dron.owl

Vigabatrin Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Vigabatrin
has_RxCUI: 374291
see also: RxNORM: RXNORM/14851
see also: NDF-RT: N0000171807
imported from: dron.owl

zafirlukast Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Leukotriene Receptor Antagonists [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: zafirlukast
has_RxCUI: 374330
see also: RxNORM: RXNORM/114970
see also: NDF-RT: N0000148457
imported from: dron.owl

Zidovudine Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Reverse Transcriptase Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Zidovudine
has_RxCUI: 374332
see also: NDF-RT: N0000147622
see also: RxNORM: RXNORM/11413
imported from: dron.owl

zolmitriptan Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has role
  some values from: Serotonin Agonists [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: zolmitriptan
has_RxCUI: 374363
see also: RxNORM: RXNORM/135775
see also: NDF-RT: N0000148550
imported from: dron.owl

zolpidem Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: GABA A Modulators [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: zolpidem
has_RxCUI: 374364
see also: NDF-RT: N0000021601
see also: RxNORM: RXNORM/39993
imported from: dron.owl

clopidogrel Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: clopidogrel
has_RxCUI: 374583
imported from: dron.owl

pioglitazone Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: pioglitazone
has_RxCUI: 374606
imported from: dron.owl

zaleplon Oral Capsule
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: zaleplon
subclass of: Restriction
  on property: has participant
  some values from: GABA A Receptor Interactions [MoA]
has_RxCUI: 374609
see also: NDF-RT: N0000148625
see also: RxNORM: RXNORM/74667
imported from: dron.owl

moxifloxacin Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: moxifloxacin
subclass of: Restriction
  on property: has participant
  some values from: Topoisomerase Inhibitors [MoA]
has_RxCUI: 374619
see also: RxNORM: RXNORM/139462
see also: NDF-RT: N0000148632
imported from: dron.owl

gatifloxacin Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: gatifloxacin
has_RxCUI: 374621
imported from: dron.owl

linezolid Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Protein Synthesis Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: linezolid
has_RxCUI: 374626
see also: RxNORM: RXNORM/190376
see also: NDF-RT: N0000148664
imported from: dron.owl

ziprasidone Oral Capsule
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has role
  some values from: Serotonin Antagonists [MoA]
subclass of: Restriction
  on property: has role
  some values from: Dopamine Antagonists [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: ziprasidone
subclass of: Restriction
  on property: has role
  some values from: Histamine H1 Receptor Antagonists [MoA]
subclass of: Restriction
  on property: has role
  some values from: Adrenergic alpha-Antagonists [MoA]
has_RxCUI: 374649
see also: RxNORM: RXNORM/115698
see also: NDF-RT: N0000148690
imported from: dron.owl

valganciclovir Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Nucleic Acid Synthesis Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: valganciclovir
has_RxCUI: 374656
see also: RxNORM: RXNORM/275891
see also: NDF-RT: N0000148704
imported from: dron.owl

mycophenolate mofetil Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: mycophenolate mofetil
has_RxCUI: 374667
imported from: dron.owl

peginterferon alfa-2b Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: peginterferon alfa-2b
subclass of: Restriction
  on property: has participant
  some values from: Biological Response Modifiers [MoA]
has_RxCUI: 374678
see also: RxNORM: RXNORM/253453
see also: NDF-RT: N0000148697
imported from: dron.owl

exemestane Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Enzyme Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: exemestane
has_RxCUI: 375061
see also: NDF-RT: N0000148637
see also: RxNORM: RXNORM/258494
imported from: dron.owl

Mitoxantrone Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Mitoxantrone
subclass of: Restriction
  on property: has participant
  some values from: Topoisomerase Inhibitors [MoA]
has_RxCUI: 375173
see also: RxNORM: RXNORM/203129
see also: RxNORM: RXNORM/7005
see also: NDF-RT: N0000147641
see also: NDF-RT: N0000147929
imported from: dron.owl

Pentamidine Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Pentamidine
has_RxCUI: 375205
see also: NDF-RT: N0000147966
see also: RxNORM: RXNORM/7994
imported from: dron.owl

rabeprazole Enteric Coated Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: rabeprazole
has_RxCUI: 375256
imported from: dron.owl

zonisamide Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: zonisamide
has_RxCUI: 375369
see also: NDF-RT: N0000148668
see also: RxNORM: RXNORM/39998
imported from: dron.owl

cefepime Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Enzyme Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: cefepime
has_RxCUI: 375794
see also: NDF-RT: N0000022054
see also: RxNORM: RXNORM/20481
imported from: dron.owl

Aurothiomalate Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Aurothiomalate
has_RxCUI: 376337
see also: RxNORM: RXNORM/4981
see also: NDF-RT: N0000146340
imported from: dron.owl

Deferoxamine Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Deferoxamine
subclass of: Restriction
  on property: has participant
  some values from: Iron Chelating Activity [MoA]
has_RxCUI: 376374
see also: NDF-RT: N0000147797
see also: RxNORM: RXNORM/3131
imported from: dron.owl

rofecoxib Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Cyclooxygenase 2 Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: rofecoxib
has_RxCUI: 376431
see also: NDF-RT: N0000148611
see also: RxNORM: RXNORM/232158
imported from: dron.owl

Cisplatin Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Cisplatin
subclass of: Restriction
  on property: has participant
  some values from: Nucleic Acid Synthesis Inhibitors [MoA]
has_RxCUI: 376433
see also: NDF-RT: N0000146476
see also: RxNORM: RXNORM/2555
imported from: dron.owl

Foscarnet Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Reverse Transcriptase Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Foscarnet
has_RxCUI: 376842
see also: RxNORM: RXNORM/33562
see also: NDF-RT: N0000148246
imported from: dron.owl

gemcitabine Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Nucleic Acid Synthesis Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: gemcitabine
has_RxCUI: 376887
see also: RxNORM: RXNORM/12574
see also: NDF-RT: N0000022036
imported from: dron.owl

docetaxel Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: docetaxel
subclass of: Restriction
  on property: has participant
  some values from: Protein Synthesis Inhibitors [MoA]
has_RxCUI: 376888
see also: NDF-RT: N0000148441
see also: RxNORM: RXNORM/72962
imported from: dron.owl

Aldesleukin Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Biological Response Modifiers [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Aldesleukin
has_RxCUI: 377091
see also: RxNORM: RXNORM/70223
see also: NDF-RT: N0000148066
imported from: dron.owl

Paclitaxel Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Immunologic Adjuvants [MoA]
subclass of: Restriction
  on property: has participant
  some values from: beta Tubulin Interactions [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Paclitaxel
has_RxCUI: 377111
see also: RxNORM: RXNORM/56946
see also: NDF-RT: N0000148314
imported from: dron.owl

vinorelbine Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Tubulin Interactions [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: vinorelbine
has_RxCUI: 377125
see also: RxNORM: RXNORM/39541
see also: NDF-RT: N0000021986
imported from: dron.owl

Ifosfamide Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Ifosfamide
subclass of: Restriction
  on property: has participant
  some values from: Alkylating Activity [MoA]
has_RxCUI: 377128
see also: RxNORM: RXNORM/5657
see also: NDF-RT: N0000147596
imported from: dron.owl

Teniposide Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Teniposide
subclass of: Restriction
  on property: has participant
  some values from: Topoisomerase Inhibitors [MoA]
has_RxCUI: 377130
see also: RxNORM: RXNORM/10362
see also: NDF-RT: N0000148273
imported from: dron.owl

Cladribine Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Nucleic Acid Synthesis Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Cladribine
has_RxCUI: 377175
see also: NDF-RT: N0000148293
see also: RxNORM: RXNORM/44157
imported from: dron.owl

oxaliplatin Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: oxaliplatin
subclass of: Restriction
  on property: has participant
  some values from: Physiochemical Activity [MoA]
has_RxCUI: 377209
see also: RxNORM: RXNORM/32592
see also: NDF-RT: N0000148774
imported from: dron.owl

trastuzumab Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: trastuzumab
subclass of: Restriction
  on property: has participant
  some values from: HER2/Neu/cerbB2 Antagonists [MoA]
has_RxCUI: 377216
see also: NDF-RT: N0000148593
see also: RxNORM: RXNORM/224905
imported from: dron.owl

rituximab Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Antibody-Receptor Interactions [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: rituximab
has_RxCUI: 377259
see also: NDF-RT: N0000148560
see also: RxNORM: RXNORM/121191
imported from: dron.owl

Propofol Injectable Suspension
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Propofol
has_RxCUI: 377483
see also: RxNORM: RXNORM/8782
see also: NDF-RT: N0000147620
imported from: dron.owl

bexarotene Topical Gel
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: bexarotene
has_RxCUI: 378079
see also: RxNORM: RXNORM/233272
see also: NDF-RT: N0000148643
imported from: dron.owl

gabapentin Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: gabapentin
has_RxCUI: 378099
see also: NDF-RT: N0000148345
see also: RxNORM: RXNORM/25480
imported from: dron.owl

Bupropion Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Dopamine Uptake Inhibitors [MoA]
subclass of: Restriction
  on property: has participant
  some values from: Norepinephrine Uptake Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Bupropion
has_RxCUI: 378233
see also: NDF-RT: N0000147738
see also: RxNORM: RXNORM/42347
imported from: dron.owl

Sirolimus Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Sirolimus
has_RxCUI: 378277
imported from: dron.owl

ropivacaine Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: ropivacaine
subclass of: Restriction
  on property: has participant
  some values from: Sodium Channel Interactions [MoA]
has_RxCUI: 378318
see also: RxNORM: RXNORM/35780
see also: NDF-RT: N0000022060
imported from: dron.owl

Carboplatin Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Nucleic Acid Synthesis Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Carboplatin
has_RxCUI: 378363
see also: NDF-RT: N0000147598
see also: RxNORM: RXNORM/40048
imported from: dron.owl

histrelin Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: histrelin
has_RxCUI: 378634
see also: RxNORM: RXNORM/50975
see also: NDF-RT: N0000176176
imported from: dron.owl

montelukast Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Leukotriene Receptor Antagonists [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: montelukast
has_RxCUI: 378682
see also: RxNORM: RXNORM/88249
see also: NDF-RT: N0000022122
imported from: dron.owl

valdecoxib Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: valdecoxib
subclass of: Restriction
  on property: has participant
  some values from: Cyclooxygenase 2 Inhibitors [MoA]
has_RxCUI: 378686
see also: NDF-RT: N0000148721
see also: RxNORM: RXNORM/278567
imported from: dron.owl

vardenafil Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Phosphodiesterase 5 Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: vardenafil
has_RxCUI: 378688
see also: RxNORM: RXNORM/306674
see also: NDF-RT: N0000148820
imported from: dron.owl

voriconazole Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: voriconazole
subclass of: Restriction
  on property: has participant
  some values from: 14-alpha Demethylase Inhibitors [MoA]
has_RxCUI: 378691
see also: NDF-RT: N0000148767
see also: RxNORM: RXNORM/121243
imported from: dron.owl

Paroxetine Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Serotonin Uptake Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Paroxetine
has_RxCUI: 378925
see also: NDF-RT: N0000148335
see also: RxNORM: RXNORM/32937
imported from: dron.owl

Insulin, Protamine Zinc, Human Injectable Suspension
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Insulin, Protamine Zinc, Human
has_RxCUI: 379009
imported from: dron.owl

Zalcitabine Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Zalcitabine
subclass of: Restriction
  on property: has participant
  some values from: Reverse Transcriptase Inhibitors [MoA]
has_RxCUI: 379127
see also: RxNORM: RXNORM/3363
see also: NDF-RT: N0000021287
imported from: dron.owl

Triptorelin Injectable Suspension
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Triptorelin
subclass of: Restriction
  on property: has participant
  some values from: Hypothalamic Hormone Receptor Agonists [MoA]
has_RxCUI: 379232
see also: NDF-RT: N0000148818
see also: RxNORM: RXNORM/38782
imported from: dron.owl

fludarabine Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Nucleic Acid Synthesis Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: fludarabine
has_RxCUI: 393413
see also: NDF-RT: N0000148244
see also: RxNORM: RXNORM/24698
see also: RxNORM: RXNORM/25102
see also: NDF-RT: N0000148119
imported from: dron.owl

Omeprazole Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Proton Pump Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Omeprazole
has_RxCUI: 393435
see also: RxNORM: RXNORM/7646
see also: NDF-RT: N0000147569
imported from: dron.owl

fluticasone Nasal Suspension
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Glucocorticoid Receptor Agonists [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: fluticasone
has_RxCUI: 393446
see also: RxNORM: RXNORM/41126
see also: NDF-RT: N0000148245
imported from: dron.owl

Miglustat Oral Capsule
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Miglustat
subclass of: Restriction
  on property: has participant
  some values from: Glucosylceramide Synthase Inhibitors [MoA]
has_RxCUI: 402347
see also: RxNORM: RXNORM/402316
see also: NDF-RT: N0000148822
imported from: dron.owl

bortezomib Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Ubiquitin Ligase Inhibitors [MoA]
subclass of: Restriction
  on property: has participant
  some values from: Proteasome Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: bortezomib
has_RxCUI: 402394
see also: RxNORM: RXNORM/358258
see also: NDF-RT: N0000148811
imported from: dron.owl

tadalafil Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: tadalafil
subclass of: Restriction
  on property: has participant
  some values from: Phosphodiesterase 5 Inhibitors [MoA]
has_RxCUI: 402452
see also: NDF-RT: N0000148829
see also: RxNORM: RXNORM/358263
imported from: dron.owl

imatinib Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Bcr-Abl Tyrosine Kinase Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: imatinib
has_RxCUI: 406050
see also: NDF-RT: N0000148698
see also: RxNORM: RXNORM/282388
imported from: dron.owl

pemetrexed Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Dihydrofolate Reductase Inhibitors [MoA]
subclass of: Restriction
  on property: has participant
  some values from: Thymidylate Synthetase Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: pemetrexed
has_RxCUI: 406178
see also: RxNORM: RXNORM/68446
see also: NDF-RT: N0000148831
imported from: dron.owl

butalbital Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: butalbital
has_RxCUI: 435471
imported from: dron.owl

Tacrolimus Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Tacrolimus
has_RxCUI: 451875
see also: RxNORM: RXNORM/42316
see also: NDF-RT: N0000148372
imported from: dron.owl

Streptomycin Oral Capsule
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Protein Synthesis Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Streptomycin
has_RxCUI: 451949
see also: NDF-RT: N0000148018
see also: RxNORM: RXNORM/10109
imported from: dron.owl

Thalidomide Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Thalidomide
has_RxCUI: 452059
see also: RxNORM: RXNORM/10432
see also: NDF-RT: N0000148588
imported from: dron.owl

pregabalin Oral Capsule
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: pregabalin
has_RxCUI: 483437
see also: NDF-RT: N0000023107
see also: RxNORM: RXNORM/187832
imported from: dron.owl

Saquinavir Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Saquinavir
subclass of: Restriction
  on property: has participant
  some values from: HIV Protease Inhibitors [MoA]
has_RxCUI: 485467
see also: NDF-RT: N0000148419
see also: RxNORM: RXNORM/83395
imported from: dron.owl

Flecainide Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Flecainide
subclass of: Restriction
  on property: has participant
  some values from: Ion Channel Interactions [MoA]
has_RxCUI: 498897
see also: RxNORM: RXNORM/4441
see also: NDF-RT: N0000147848
imported from: dron.owl

Nitrofurantoin Oral Capsule
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Enzyme Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Nitrofurantoin
has_RxCUI: 498905
see also: RxNORM: RXNORM/221129
see also: NDF-RT: N0000147151
see also: RxNORM: RXNORM/7454
see also: NDF-RT: N0000163521
imported from: dron.owl

tipranavir Oral Capsule
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: tipranavir
has_RxCUI: 577211
see also: NDF-RT: N0000023100
see also: RxNORM: RXNORM/190548
imported from: dron.owl

lansoprazole Oral Capsule
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: Proton Pump Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: lansoprazole
has_RxCUI: 596836
see also: NDF-RT: N0000148407
see also: RxNORM: RXNORM/17128
imported from: dron.owl

sorafenib Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: sorafenib
has_RxCUI: 597746
see also: NDF-RT: N0000171742
see also: RxNORM: RXNORM/495881
imported from: dron.owl

nelarabine Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: nelarabine
has_RxCUI: 603565
see also: NDF-RT: N0000171753
see also: RxNORM: RXNORM/274771
imported from: dron.owl

rasagiline Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: rasagiline
has_RxCUI: 608327
see also: RxNORM: RXNORM/134748
see also: NDF-RT: N0000171790
imported from: dron.owl

Nalidixate Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Nalidixate
has_RxCUI: 618427
imported from: dron.owl

tenofovir disoproxil Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: tenofovir disoproxil
subclass of: Restriction
  on property: has participant
  some values from: Non-Nucleoside Reverse Transcriptase Inhibitors [MoA]
has_RxCUI: 632025
see also: RxNORM: RXNORM/117466
see also: NDF-RT: N0000148716
imported from: dron.owl

emtricitabine Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: emtricitabine
has_RxCUI: 639882
see also: RxNORM: RXNORM/276237
see also: NDF-RT: N0000148813
imported from: dron.owl

posaconazole Oral Suspension
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: posaconazole
has_RxCUI: 665018
imported from: dron.owl

telbivudine Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: telbivudine
has_RxCUI: 665121
see also: RxNORM: RXNORM/474128
see also: NDF-RT: N0000176071
imported from: dron.owl

Triamcinolone Prefilled Syringe
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Triamcinolone
has_RxCUI: 727885
imported from: dron.owl

Pramipexole Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Pramipexole
subclass of: Restriction
  on property: has participant
  some values from: Dopamine Agonists [MoA]
has_RxCUI: 745021
see also: NDF-RT: N0000022076
see also: RxNORM: RXNORM/746741
imported from: dron.owl

nilotinib Oral Capsule
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: nilotinib
has_RxCUI: 746605
see also: NDF-RT: N0000176124
see also: RxNORM: RXNORM/662281
imported from: dron.owl

fluticasone Dry Powder Inhaler
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: fluticasone
has_RxCUI: 746765
imported from: dron.owl

Topotecan Oral Capsule
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Topotecan
subclass of: Restriction
  on property: has participant
  some values from: Topoisomerase Inhibitors [MoA]
has_RxCUI: 747192
see also: NDF-RT: N0000022037
see also: RxNORM: RXNORM/57308
imported from: dron.owl

certolizumab pegol Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: certolizumab pegol
has_RxCUI: 795080
imported from: dron.owl

certolizumab pegol Prefilled Syringe
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: certolizumab pegol
has_RxCUI: 849596
see also: NDF-RT: N0000178499
see also: RxNORM: RXNORM/709271
imported from: dron.owl

tocilizumab Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: tocilizumab
has_RxCUI: 895759
imported from: dron.owl

Ritonavir Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has participant
  some values from: HIV Protease Inhibitors [MoA]
subclass of: Restriction
  on property: has_proper_part
  some values from: Ritonavir
has_RxCUI: 900574
see also: NDF-RT: N0000148436
see also: RxNORM: RXNORM/85762
imported from: dron.owl

tesamorelin Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: tesamorelin
has_RxCUI: 1044586
see also: RxNORM: RXNORM/1044584
see also: NDF-RT: N0000182253
imported from: dron.owl

Vemurafenib Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: Vemurafenib
has_RxCUI: 1147222
see also: NDF-RT: N0000183250
see also: RxNORM: RXNORM/1147220
imported from: dron.owl

avanafil Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: avanafil
has_RxCUI: 1291305
see also: RxNORM: RXNORM/1291301
imported from: dron.owl

carfilzomib Injectable Solution
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: carfilzomib
has_RxCUI: 1302969
see also: RxNORM: RXNORM/1302966
see also: NDF-RT: N0000185509
imported from: dron.owl

teriflunomide Oral Tablet
type: Class
subclass of: drug product
subclass of: Restriction
  on property: has_proper_part
  some values from: teriflunomide
has_RxCUI: 1310524
see also: NDF-RT: N0000185727
see also: RxNORM: RXNORM/1310520
imported from: dron.owl

penicillin G benzathine 115 MG/ML Oral Solution
type: Class
subclass of: Penicillin G Oral Solution
subclass of: Restriction
  on property: has participant
  some values from: Transpeptidase Inhibitors [MoA]
has_RxCUI: 102692
see also: NDF-RT: N0000145827
see also: RxNORM: RXNORM/7982
imported from: dron.owl

Procarbazine 50 MG Oral Capsule
type: Class
subclass of: Procarbazine Oral Capsule
has_RxCUI: 314167
imported from: dron.owl

pioglitazone 15 MG Oral Tablet
type: Class
subclass of: pioglitazone Oral Tablet
has_RxCUI: 317573
imported from: dron.owl

Leuprolide Acetate 5 MG/ML Injectable Solution
type: Class
subclass of: Leuprolide Injectable Solution
subclass of: Restriction
  on property: has participant
  some values from: Hormone Receptor Modulators [MoA]
has_RxCUI: 545835
see also: NDF-RT: N0000147256
see also: RxNORM: RXNORM/203217
imported from: dron.owl

0.1 ML Triamcinolone Acetonide 80 MG/ML Prefilled Syringe
type: Class
subclass of: Triamcinolone Prefilled Syringe
has_RxCUI: 833449
imported from: dron.owl

Enalapril Maleate 2.5 MG Oral Tablet
type: Class
subclass of: Enalapril Oral Tablet
subclass of: Restriction
  on property: has participant
  some values from: Angiotensin-converting Enzyme Inhibitors [MoA]
has_RxCUI: 858804
see also: RxNORM: RXNORM/203123
see also: NDF-RT: N0000146304
imported from: dron.owl

Insulin, Protamine Zinc, Human 40 UNT/ML Injectable Suspension
type: Class
subclass of: Insulin, Protamine Zinc, Human Injectable Suspension
has_RxCUI: 966903
imported from: dron.owl

Procarbazine 50 MG Oral Capsule [Matulane]
type: Class
subclass of: Procarbazine 50 MG Oral Capsule
subclass of: Restriction
  on property: has participant
  some values from: Nucleic Acid Synthesis Inhibitors [MoA]
has_RxCUI: 207588
see also: RxNORM: RXNORM/8702
see also: NDF-RT: N0000147991
imported from: dron.owl

pioglitazone 15 MG Oral Tablet [Actos]
type: Class
subclass of: pioglitazone 15 MG Oral Tablet
has_RxCUI: 261266
imported from: dron.owl

0.1 ML Triamcinolone Acetonide 80 MG/ML Prefilled Syringe [Trivaris]
type: Class
subclass of: 0.1 ML Triamcinolone Acetonide 80 MG/ML Prefilled Syringe
has_RxCUI: 835559
imported from: dron.owl

Insulin, Protamine Zinc, Human 40 UNT/ML Injectable Suspension [ProZinc]
type: Class
subclass of: Insulin, Protamine Zinc, Human 40 UNT/ML Injectable Suspension
subclass of: Restriction
  on property: has participant
  some values from: Insulin Receptor Agonists [MoA]
has_RxCUI: 966907
see also: NDF-RT: N0000147876
see also: RxNORM: RXNORM/5856
imported from: dron.owl

negative regulation of transcription from RNA polymerase II promoter
type: Class
subclass of: regulation of transcription from RNA polymerase II promoter
subclass of: negative regulation of transcription, DNA-templated
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
id: GO:0000122
has_alternative_id: GO:0010553
has_alternative_id: GO:0045816
has_obo_namespace: biological_process
has_related_synonym: down regulation of global transcription from RNA polymerase II promoter
has_exact_synonym: down regulation of transcription from RNA polymerase II promoter
has_related_synonym: down-regulation of global transcription from RNA polymerase II promoter
has_exact_synonym: down-regulation of transcription from RNA polymerase II promoter
has_related_synonym: downregulation of global transcription from RNA polymerase II promoter
has_exact_synonym: downregulation of transcription from RNA polymerase II promoter
has_related_synonym: inhibition of global transcription from RNA polymerase II promoter
has_exact_synonym: inhibition of transcription from RNA polymerase II promoter
has_related_synonym: negative regulation of gene-specific transcription from RNA polymerase II promoter
has_related_synonym: negative regulation of global transcription from Pol II promoter
has_exact_synonym: negative regulation of transcription from Pol II promoter
has_related_synonym: negative regulation of transcription from RNA polymerase II promoter, global
imported from: go.owl

embryonic epithelial tube formation
type: Class
subclass of: epithelial tube formation
subclass of: Restriction
  on property: part_of
  some values from: morphogenesis of embryonic epithelium
imported from: oae.owl
imported from: uberon.owl

neural tube formation
type: Class
subclass of: embryonic epithelial tube formation
subclass of: Restriction
  on property: part_of
  some values from: neural tube development
imported from: oae.owl
imported from: uberon.owl

regulation of cytokine-mediated signaling pathway
type: Class
subclass of: regulation of signal transduction
subclass of: regulation of response to cytokine stimulus
definition: Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway.
id: GO:0001959
has_obo_namespace: biological_process
has_exact_synonym: regulation of cytokine and chemokine mediated signaling pathway
has_exact_synonym: regulation of cytokine mediated signaling pathway
has_exact_synonym: regulation of cytokine mediated signalling pathway
imported from: go.owl

negative regulation of cytokine-mediated signaling pathway
type: Class
subclass of: regulation of cytokine-mediated signaling pathway
subclass of: negative regulation of signal transduction
subclass of: negative regulation of response to cytokine stimulus
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway.
id: GO:0001960
has_obo_namespace: biological_process
has_exact_synonym: down regulation of cytokine mediated signaling pathway
has_exact_synonym: down-regulation of cytokine mediated signaling pathway
has_exact_synonym: downregulation of cytokine mediated signaling pathway
has_narrow_synonym: inhibition of cytokine mediated signaling pathway
has_exact_synonym: negative regulation of cytokine and chemokine mediated signaling pathway
has_exact_synonym: negative regulation of cytokine mediated signaling pathway
has_exact_synonym: negative regulation of cytokine mediated signalling pathway
imported from: go.owl

morphogenesis of an epithelium
type: Class
subclass of: tissue morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: epithelium development
imported from: oae.owl
imported from: uberon.owl

system process
type: Class
subclass of: single-multicellular organism process
imported from: go.owl
imported from: oae.owl
imported from: uberon.owl

cellular_component
type: Class
subclass of: material entity
imported from: go.owl
imported from: oae.owl
imported from: uberon.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast
in_subset: gosubset prok

cell
type: Class
subclass of: cellular_component
imported from: go.owl
imported from: oae.owl
imported from: uberon.owl
in_subset: goslim generic
in_subset: goslim plant
in_subset: gosubset prok

regulation of transcription, DNA-templated
type: Class
subclass of: regulation of gene expression
subclass of: regulation of nucleic acid-templated transcription
subclass of: regulation of cellular macromolecule biosynthetic process
definition: Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
id: GO:0006355
has_alternative_id: GO:0032583
has_alternative_id: GO:0045449
has_alternative_id: GO:0061019
has_obo_namespace: biological_process
has_exact_synonym: regulation of cellular transcription, DNA-dependent
has_related_synonym: regulation of gene-specific transcription
has_exact_synonym: regulation of transcription, DNA-dependent
has_broad_synonym: transcriptional control
imported from: go.owl
in_subset: goslim pombe
in_subset: gosubset prok

regulation of transcription from RNA polymerase II promoter
type: Class
subclass of: regulation of transcription, DNA-templated
definition: Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
id: GO:0006357
has_alternative_id: GO:0006358
has_alternative_id: GO:0010551
has_obo_namespace: biological_process
has_related_synonym: global transcription regulation from Pol II promoter
has_related_synonym: regulation of gene-specific transcription from RNA polymerase II promoter
has_related_synonym: regulation of global transcription from Pol II promoter
has_exact_synonym: regulation of transcription from Pol II promoter
has_related_synonym: regulation of transcription from RNA polymerase II promoter, global
imported from: go.owl

multicellular organismal development
type: Class
subclass of: single-multicellular organism process
subclass of: single-organism developmental process
imported from: go.owl
imported from: oae.owl
imported from: uberon.owl
in_subset: goslim plant

gastrulation
type: Class
subclass of: embryonic morphogenesis
imported from: oae.owl
imported from: uberon.owl

nervous system development
type: Class
subclass of: system development
imported from: oae.owl
imported from: uberon.owl

sensory perception
type: Class
subclass of: neurological system process
imported from: oae.owl
imported from: uberon.owl

visual perception
type: Class
subclass of: sensory perception of light stimulus
imported from: oae.owl
imported from: uberon.owl

biological_process
type: Class
subclass of: process
definition: Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
has_alternative_id: GO:0000004
has_alternative_id: GO:0007582
id: GO:0008150
comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. Note that when this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
database_cross_reference: Wikipedia:Biological_process
has_exact_synonym: biological process
has_obo_namespace: biological_process
has_exact_synonym: physiological process
imported from: go.owl
imported from: oae.owl
imported from: uberon.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim pombe
in_subset: goslim yeast
in_subset: gosubset prok

regulation of G-protein coupled receptor protein signaling pathway
type: Class
subclass of: regulation of signal transduction
definition: Any process that modulates the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity.
id: GO:0008277
has_obo_namespace: biological_process
has_exact_synonym: regulation of G protein coupled receptor protein signaling pathway
has_exact_synonym: regulation of G protein coupled receptor protein signalling pathway
has_exact_synonym: regulation of G-protein coupled receptor protein signalling pathway
has_exact_synonym: regulation of G-protein-coupled receptor protein signaling pathway
has_exact_synonym: regulation of G-protein-coupled receptor protein signalling pathway
has_exact_synonym: regulation of GPCR protein signaling pathway
has_exact_synonym: regulation of GPCR protein signalling pathway
imported from: go.owl

response to radiation
type: Class
subclass of: response to abiotic stimulus
imported from: oae.owl
imported from: uberon.owl

response to light stimulus
type: Class
subclass of: response to radiation
imported from: oae.owl
imported from: uberon.owl

detection of external stimulus
type: Class
subclass of: response to external stimulus
subclass of: detection of stimulus
imported from: oae.owl
imported from: uberon.owl

detection of abiotic stimulus
type: Class
subclass of: response to abiotic stimulus
subclass of: detection of stimulus
imported from: oae.owl
imported from: uberon.owl

detection of light stimulus
type: Class
subclass of: response to light stimulus
subclass of: detection of external stimulus
subclass of: detection of abiotic stimulus
imported from: oae.owl
imported from: uberon.owl

detection of visible light
type: Class
subclass of: detection of light stimulus
imported from: oae.owl
imported from: uberon.owl

response to external stimulus
type: Class
subclass of: response to stimulus
imported from: go.owl
imported from: oae.owl
imported from: uberon.owl
in_subset: goslim plant
in_subset: gosubset prok
in_subset: high level annotation qc

response to abiotic stimulus
type: Class
subclass of: response to stimulus
imported from: oae.owl
imported from: uberon.owl

anatomical structure morphogenesis
type: Class
subclass of: developmental process
subclass of: Restriction
  on property: part_of
  some values from: anatomical structure development
imported from: go.owl
imported from: oae.owl
imported from: uberon.owl
in_subset: goslim plant
in_subset: gosubset prok

embryo development
type: Class
subclass of: single-organism developmental process
subclass of: anatomical structure development
subclass of: Restriction
  on property: part_of
  some values from: multicellular organismal development
imported from: oae.owl
imported from: uberon.owl

post-embryonic development
type: Class
subclass of: single-multicellular organism process
subclass of: single-organism developmental process
subclass of: Restriction
  on property: part_of
  some values from: multicellular organismal development
imported from: oae.owl
imported from: uberon.owl

embryo development ending in birth or egg hatching
type: Class
subclass of: embryo development
imported from: oae.owl
imported from: uberon.owl

tissue development
type: Class
subclass of: anatomical structure development
imported from: oae.owl
imported from: uberon.owl

regulation of biosynthetic process
type: Class
subclass of: regulation of metabolic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.
id: GO:0009889
has_obo_namespace: biological_process
has_exact_synonym: regulation of anabolism
has_exact_synonym: regulation of biosynthesis
has_exact_synonym: regulation of formation
has_exact_synonym: regulation of synthesis
imported from: go.owl
in_subset: gosubset prok

negative regulation of biosynthetic process
type: Class
subclass of: regulation of biosynthetic process
subclass of: negative regulation of metabolic process
definition: Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.
id: GO:0009890
has_obo_namespace: biological_process
has_exact_synonym: down regulation of biosynthetic process
has_exact_synonym: down-regulation of biosynthetic process
has_exact_synonym: downregulation of biosynthetic process
has_narrow_synonym: inhibition of biosynthetic process
has_exact_synonym: negative regulation of anabolism
has_exact_synonym: negative regulation of biosynthesis
has_exact_synonym: negative regulation of formation
has_exact_synonym: negative regulation of synthesis
imported from: go.owl
in_subset: gosubset prok

negative regulation of metabolic process
type: Class
subclass of: regulation of metabolic process
subclass of: negative regulation of biological process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
id: GO:0009892
has_obo_namespace: biological_process
has_exact_synonym: down regulation of metabolic process
has_exact_synonym: down-regulation of metabolic process
has_exact_synonym: downregulation of metabolic process
has_narrow_synonym: inhibition of metabolic process
has_exact_synonym: negative regulation of metabolism
imported from: go.owl
in_subset: gosubset prok

regulation of signal transduction
type: Class
subclass of: regulation of cell communication
subclass of: regulation of signaling
subclass of: regulation of response to stimulus
definition: Any process that modulates the frequency, rate or extent of signal transduction.
id: GO:0009966
has_alternative_id: GO:0035466
has_obo_namespace: biological_process
has_related_synonym: regulation of signaling pathway
has_related_synonym: regulation of signalling pathway
imported from: go.owl
in_subset: gosubset prok

positive regulation of signal transduction
type: Class
subclass of: regulation of signal transduction
subclass of: positive regulation of cell communication
subclass of: positive regulation of signaling
subclass of: positive regulation of response to stimulus
definition: Any process that activates or increases the frequency, rate or extent of signal transduction.
id: GO:0009967
has_alternative_id: GO:0035468
database_cross_reference: Reactome:REACT_6227
has_narrow_synonym: activation of signal transduction
has_obo_namespace: biological_process
has_related_synonym: positive regulation of signaling pathway
has_related_synonym: positive regulation of signalling pathway
has_narrow_synonym: stimulation of signal transduction
has_exact_synonym: up regulation of signal transduction
has_exact_synonym: up-regulation of signal transduction
has_exact_synonym: upregulation of signal transduction
imported from: go.owl
in_subset: gosubset prok

negative regulation of signal transduction
type: Class
subclass of: regulation of signal transduction
subclass of: negative regulation of cell communication
subclass of: negative regulation of signaling
subclass of: negative regulation of response to stimulus
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.
id: GO:0009968
has_alternative_id: GO:0035467
database_cross_reference: Reactome:REACT_6334
has_obo_namespace: biological_process
has_exact_synonym: down regulation of signal transduction
has_exact_synonym: down-regulation of signal transduction
has_exact_synonym: downregulation of signal transduction
has_narrow_synonym: inhibition of signal transduction
has_related_synonym: negative regulation of signaling pathway
has_related_synonym: negative regulation of signalling pathway
imported from: go.owl
in_subset: gosubset prok

cellular process
type: Class
subclass of: biological_process
imported from: go.owl
imported from: oae.owl
imported from: uberon.owl
in_subset: goslim pir
in_subset: goslim plant
in_subset: gosubset prok

regulation of gene expression
type: Class
subclass of: regulation of macromolecule metabolic process
definition: Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
id: GO:0010468
database_cross_reference: Wikipedia:Regulation_of_gene_expression
has_obo_namespace: biological_process
has_related_synonym: regulation of gene product expression
has_narrow_synonym: regulation of protein expression
imported from: go.owl
in_subset: gosubset prok

regulation of receptor activity
type: Class
subclass of: regulation of signal transduction
subclass of: regulation of molecular function
definition: Any process that modulates the frequency, rate or extent of receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity.
id: GO:0010469
has_obo_namespace: biological_process
imported from: go.owl

regulation of macromolecule biosynthetic process
type: Class
subclass of: regulation of biosynthetic process
subclass of: regulation of macromolecule metabolic process
definition: Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
id: GO:0010556
has_obo_namespace: biological_process
imported from: go.owl
in_subset: gosubset prok

negative regulation of macromolecule biosynthetic process
type: Class
subclass of: negative regulation of biosynthetic process
subclass of: regulation of macromolecule biosynthetic process
subclass of: negative regulation of macromolecule metabolic process
definition: Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
id: GO:0010558
has_obo_namespace: biological_process
imported from: go.owl

negative regulation of macromolecule metabolic process
type: Class
subclass of: negative regulation of metabolic process
subclass of: regulation of macromolecule metabolic process
definition: Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
id: GO:0010605
has_obo_namespace: biological_process
imported from: go.owl

negative regulation of gene expression
type: Class
subclass of: regulation of gene expression
subclass of: negative regulation of macromolecule metabolic process
definition: Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
id: GO:0010629
has_obo_namespace: biological_process
imported from: go.owl

regulation of cell communication
type: Class
subclass of: regulation of cellular process
definition: Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
id: GO:0010646
has_obo_namespace: biological_process
imported from: go.owl

positive regulation of cell communication
type: Class
subclass of: regulation of cell communication
subclass of: positive regulation of cellular process
definition: Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
id: GO:0010647
has_obo_namespace: biological_process
imported from: go.owl

negative regulation of cell communication
type: Class
subclass of: regulation of cell communication
subclass of: negative regulation of cellular process
definition: Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
id: GO:0010648
has_obo_namespace: biological_process
imported from: go.owl

negative regulation of tumor necrosis factor-mediated signaling pathway
type: Class
subclass of: regulation of cytokine-mediated signaling pathway
subclass of: negative regulation of cytokine-mediated signaling pathway
definition: Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
id: GO:0010804
has_obo_namespace: biological_process
has_exact_synonym: negative regulation of TNF signaling
has_exact_synonym: negative regulation of TNF-mediated signaling pathway
has_exact_synonym: negative regulation of tumor necrosis factor-mediated signalling pathway
imported from: go.owl

regulation of dopamine secretion
type: Class
subclass of: regulation of ion transport
subclass of: regulation of anion transport
subclass of: regulation of catecholamine secretion
definition: Any process that modulates the frequency, rate or extent of the regulated release of dopamine.
id: GO:0014059
has_obo_namespace: biological_process
imported from: go.owl

death
type: Class
subclass of: single-organism process
imported from: go.owl
imported from: oae.owl
imported from: uberon.owl
in_subset: goslim plant
in_subset: gosubset prok

morphogenesis of embryonic epithelium
type: Class
subclass of: morphogenesis of an epithelium
subclass of: embryonic morphogenesis
imported from: oae.owl
imported from: uberon.owl

regulation of lipid metabolic process
type: Class
subclass of: regulation of primary metabolic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
id: GO:0019216
has_obo_namespace: biological_process
has_exact_synonym: regulation of lipid metabolism
imported from: go.owl
in_subset: gosubset prok

regulation of nucleobase-containing compound metabolic process
type: Class
subclass of: regulation of cellular metabolic process
subclass of: regulation of nitrogen compound metabolic process
subclass of: regulation of primary metabolic process
definition: Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
id: GO:0019219
has_obo_namespace: biological_process
has_related_synonym: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
has_exact_synonym: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
imported from: go.owl
in_subset: gosubset prok

regulation of metabolic process
type: Class
subclass of: regulation of biological process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
id: GO:0019222
has_obo_namespace: biological_process
has_exact_synonym: regulation of metabolism
imported from: go.owl
in_subset: gosubset prok

neural tube development
type: Class
subclass of: single-organism developmental process
subclass of: anatomical structure development
subclass of: Restriction
  on property: part_of
  some values from: nervous system development
subclass of: Restriction
  on property: part_of
  some values from: chordate embryonic development
imported from: oae.owl
imported from: uberon.owl

regulation of signaling
type: Class
subclass of: regulation of biological process
creation date: 2010-02-16T09:30:50Z
definition: Any process that modulates the frequency, rate or extent of a signaling process.
id: GO:0023051
has_obo_namespace: biological_process
has_related_synonym: regulation of signaling process
has_related_synonym: regulation of signalling process
imported from: go.owl

positive regulation of signaling
type: Class
subclass of: regulation of signaling
subclass of: positive regulation of biological process
creation date: 2010-02-16T09:30:50Z
definition: Any process that activates, maintains or increases the frequency, rate or extent of a signaling process.
id: GO:0023056
has_obo_namespace: biological_process
has_related_synonym: positive regulation of signaling process
has_exact_synonym: positive regulation of signalling process
imported from: go.owl

negative regulation of signaling
type: Class
subclass of: regulation of signaling
subclass of: negative regulation of biological process
creation date: 2010-02-16T09:30:50Z
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process.
id: GO:0023057
has_obo_namespace: biological_process
has_related_synonym: negative regulation of signaling process
has_related_synonym: negative regulation of signalling process
imported from: go.owl

extracellular matrix
type: Class
subclass of: cellular_component
imported from: oae.owl
imported from: uberon.owl

regulation of cellular metabolic process
type: Class
subclass of: regulation of metabolic process
subclass of: regulation of cellular process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
id: GO:0031323
has_obo_namespace: biological_process
has_exact_synonym: regulation of cellular metabolism
imported from: go.owl
in_subset: gosubset prok

negative regulation of cellular metabolic process
type: Class
subclass of: negative regulation of metabolic process
subclass of: regulation of cellular metabolic process
subclass of: negative regulation of cellular process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
id: GO:0031324
has_obo_namespace: biological_process
has_exact_synonym: down regulation of cellular metabolic process
has_exact_synonym: down-regulation of cellular metabolic process
has_exact_synonym: downregulation of cellular metabolic process
has_narrow_synonym: inhibition of cellular metabolic process
has_exact_synonym: negative regulation of cellular metabolism
imported from: go.owl
in_subset: gosubset prok

regulation of cellular biosynthetic process
type: Class
subclass of: regulation of biosynthetic process
subclass of: regulation of cellular metabolic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
id: GO:0031326
has_obo_namespace: biological_process
has_exact_synonym: regulation of cellular anabolism
has_exact_synonym: regulation of cellular biosynthesis
has_exact_synonym: regulation of cellular formation
has_exact_synonym: regulation of cellular synthesis
imported from: go.owl
in_subset: gosubset prok

negative regulation of cellular biosynthetic process
type: Class
subclass of: negative regulation of biosynthetic process
subclass of: negative regulation of cellular metabolic process
subclass of: regulation of cellular biosynthetic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
id: GO:0031327
has_obo_namespace: biological_process
has_exact_synonym: down regulation of cellular biosynthetic process
has_exact_synonym: down-regulation of cellular biosynthetic process
has_exact_synonym: downregulation of cellular biosynthetic process
has_narrow_synonym: inhibition of cellular biosynthetic process
has_exact_synonym: negative regulation of cellular anabolism
has_exact_synonym: negative regulation of cellular biosynthesis
has_exact_synonym: negative regulation of cellular formation
has_exact_synonym: negative regulation of cellular synthesis
imported from: go.owl
in_subset: gosubset prok

regulation of synaptic transmission, dopaminergic
type: Class
subclass of: regulation of synaptic transmission
definition: Any process that modulates the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine.
id: GO:0032225
has_obo_namespace: biological_process
imported from: go.owl

negative regulation of synaptic transmission, dopaminergic
type: Class
subclass of: regulation of synaptic transmission, dopaminergic
subclass of: negative regulation of synaptic transmission
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine.
id: GO:0032227
has_obo_namespace: biological_process
has_exact_synonym: down regulation of synaptic transmission, dopaminergic
has_exact_synonym: down-regulation of synaptic transmission, dopaminergic
has_exact_synonym: downregulation of synaptic transmission, dopaminergic
has_narrow_synonym: inhibition of synaptic transmission, dopaminergic
imported from: go.owl

multicellular organismal process
type: Class
subclass of: biological_process
imported from: go.owl
imported from: oae.owl
imported from: uberon.owl
in_subset: goslim pir

developmental process
type: Class
subclass of: biological_process
imported from: go.owl
imported from: oae.owl
imported from: uberon.owl
in_subset: goslim aspergillus
in_subset: goslim pir
in_subset: gosubset prok

negative regulation of ATPase activity
type: Class
subclass of: regulation of ATPase activity
subclass of: negative regulation of hydrolase activity
definition: Any process that stops or reduces the rate of ATP hydrolysis by an ATPase.
id: GO:0032780
has_obo_namespace: biological_process
has_exact_synonym: down regulation of ATPase activity
has_exact_synonym: down-regulation of ATPase activity
has_exact_synonym: downregulation of ATPase activity
has_narrow_synonym: inhibition of ATPase activity
has_exact_synonym: negative regulation of adenosinetriphosphatase activity
imported from: go.owl

regulation of localization
type: Class
subclass of: regulation of biological process
definition: Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.
id: GO:0032879
has_obo_namespace: biological_process
has_exact_synonym: regulation of localisation
imported from: go.owl
in_subset: gosubset prok

regulation of intracellular steroid hormone receptor signaling pathway
type: Class
subclass of: regulation of signal transduction
definition: Any process that modulates the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway.
id: GO:0033143
has_obo_namespace: biological_process
has_broad_synonym: regulation of steroid hormone receptor signaling pathway
has_broad_synonym: regulation of steroid hormone receptor signalling pathway
imported from: go.owl

negative regulation of intracellular steroid hormone receptor signaling pathway
type: Class
subclass of: negative regulation of signal transduction
subclass of: regulation of intracellular steroid hormone receptor signaling pathway
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway.
id: GO:0033144
has_obo_namespace: biological_process
has_broad_synonym: negative regulation of steroid hormone receptor signaling pathway
has_broad_synonym: negative regulation of steroid hormone receptor signalling pathway
imported from: go.owl

negative regulation of dopamine secretion
type: Class
subclass of: regulation of dopamine secretion
subclass of: negative regulation of catecholamine secretion
subclass of: negative regulation of anion transport
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of dopamine.
id: GO:0033602
has_obo_namespace: biological_process
has_exact_synonym: down regulation of dopamine secretion
has_exact_synonym: down-regulation of dopamine secretion
has_exact_synonym: downregulation of dopamine secretion
has_narrow_synonym: inhibition of dopamine secretion
imported from: go.owl

negative regulation of catecholamine secretion
type: Class
subclass of: regulation of catecholamine secretion
subclass of: negative regulation of amine transport
subclass of: negative regulation of secretion by cell
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine.
id: GO:0033604
has_obo_namespace: biological_process
has_exact_synonym: down regulation of catecholamine secretion
has_exact_synonym: down-regulation of catecholamine secretion
has_exact_synonym: downregulation of catecholamine secretion
has_narrow_synonym: inhibition of catecholamine secretion
imported from: go.owl

regulation of cellular amide metabolic process
type: Class
subclass of: regulation of cellular metabolic process
subclass of: regulation of nitrogen compound metabolic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides.
id: GO:0034248
has_obo_namespace: biological_process
has_exact_synonym: regulation of amide metabolism
imported from: go.owl

negative regulation of cellular amide metabolic process
type: Class
subclass of: negative regulation of cellular metabolic process
subclass of: regulation of cellular amide metabolic process
subclass of: negative regulation of nitrogen compound metabolic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides.
id: GO:0034249
has_obo_namespace: biological_process
has_exact_synonym: negative regulation of amide metabolism
imported from: go.owl

tube formation
type: Class
subclass of: single-organism developmental process
subclass of: anatomical structure formation involved in morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: tube morphogenesis
imported from: oae.owl
imported from: uberon.owl

tube morphogenesis
type: Class
subclass of: anatomical structure morphogenesis
subclass of: single-organism developmental process
subclass of: Restriction
  on property: part_of
  some values from: tube development
imported from: oae.owl
imported from: uberon.owl

tube development
type: Class
subclass of: anatomical structure development
subclass of: Restriction
  on property: part_of
  some values from: multicellular organismal development
imported from: oae.owl
imported from: uberon.owl

embryonic cleavage
type: Class
subclass of: cell division
subclass of: Restriction
  on property: part_of
  some values from: embryo development
imported from: oae.owl
imported from: uberon.owl

chordate embryonic development
type: Class
subclass of: embryo development ending in birth or egg hatching
imported from: oae.owl
imported from: uberon.owl

negative regulation of catalytic activity
type: Class
subclass of: negative regulation of metabolic process
subclass of: negative regulation of molecular function
subclass of: regulation of catalytic activity
definition: Any process that stops or reduces the activity of an enzyme.
id: GO:0043086
has_obo_namespace: biological_process
has_exact_synonym: down regulation of enzyme activity
has_exact_synonym: down-regulation of enzyme activity
has_exact_synonym: downregulation of enzyme activity
has_narrow_synonym: inhibition of enzyme activity
has_exact_synonym: negative regulation of enzyme activity
imported from: go.owl
in_subset: gosubset prok

regulation of ion transport
type: Class
subclass of: regulation of transport
definition: Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
id: GO:0043269
has_obo_namespace: biological_process
imported from: go.owl

negative regulation of ion transport
type: Class
subclass of: regulation of ion transport
subclass of: negative regulation of transport
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
id: GO:0043271
has_obo_namespace: biological_process
has_exact_synonym: down regulation of ion transport
has_exact_synonym: down-regulation of ion transport
has_exact_synonym: downregulation of ion transport
has_narrow_synonym: inhibition of ion transport
imported from: go.owl

negative regulation of sequence-specific DNA binding transcription factor activity
type: Class
subclass of: negative regulation of molecular function
subclass of: negative regulation of biological process
subclass of: regulation of sequence-specific DNA binding transcription factor activity
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
id: GO:0043433
has_obo_namespace: biological_process
has_exact_synonym: down regulation of transcription factor activity
has_exact_synonym: down-regulation of transcription factor activity
has_exact_synonym: downregulation of transcription factor activity
has_narrow_synonym: inhibition of transcription factor activity
has_broad_synonym: negative regulation of transcription factor activity
imported from: go.owl

regulation of ATPase activity
type: Class
subclass of: regulation of hydrolase activity
definition: Any process that modulates the rate of ATP hydrolysis by an ATPase.
id: GO:0043462
has_obo_namespace: biological_process
has_exact_synonym: regulation of adenosinetriphosphatase activity
imported from: go.owl

regulation of anion transport
type: Class
subclass of: regulation of ion transport
definition: Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
id: GO:0044070
has_obo_namespace: biological_process
imported from: go.owl

negative regulation of molecular function
type: Class
subclass of: regulation of molecular function
creation date: 2009-04-21T04:07:27Z
definition: Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
id: GO:0044092
has_obo_namespace: biological_process
created by: jane
imported from: go.owl

single-organism process
type: Class
subclass of: biological_process
imported from: oae.owl
imported from: uberon.owl

single-multicellular organism process
type: Class
subclass of: multicellular organismal process
subclass of: single-organism process
imported from: oae.owl
imported from: uberon.owl

single-organism cellular process
type: Class
subclass of: cellular process
subclass of: single-organism process
imported from: oae.owl
imported from: uberon.owl

single-organism developmental process
type: Class
subclass of: developmental process
subclass of: single-organism process
imported from: oae.owl
imported from: uberon.owl

positive regulation of G-protein coupled receptor protein signaling pathway
type: Class
subclass of: regulation of G-protein coupled receptor protein signaling pathway
subclass of: positive regulation of signal transduction
definition: Any process that activates or increases the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity.
id: GO:0045745
has_narrow_synonym: activation of G-protein coupled receptor protein signaling pathway
has_obo_namespace: biological_process
has_exact_synonym: positive regulation of G protein coupled receptor protein signaling pathway
has_exact_synonym: positive regulation of G protein coupled receptor protein signalling pathway
has_exact_synonym: positive regulation of G-protein coupled receptor protein signalling pathway
has_exact_synonym: positive regulation of G-protein-coupled receptor protein signaling pathway
has_exact_synonym: positive regulation of G-protein-coupled receptor protein signalling pathway
has_exact_synonym: positive regulation of GPCR protein signaling pathway
has_exact_synonym: positive regulation of GPCR protein signalling pathway
has_narrow_synonym: stimulation of G-protein coupled receptor protein signaling pathway
has_exact_synonym: up regulation of G-protein coupled receptor protein signaling pathway
has_exact_synonym: up-regulation of G-protein coupled receptor protein signaling pathway
has_exact_synonym: upregulation of G-protein coupled receptor protein signaling pathway
imported from: go.owl

negative regulation of lipid metabolic process
type: Class
subclass of: negative regulation of metabolic process
subclass of: regulation of lipid metabolic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids.
id: GO:0045833
has_obo_namespace: biological_process
has_exact_synonym: down regulation of lipid metabolic process
has_exact_synonym: down-regulation of lipid metabolic process
has_exact_synonym: downregulation of lipid metabolic process
has_narrow_synonym: inhibition of lipid metabolic process
has_exact_synonym: negative regulation of lipid metabolism
imported from: go.owl
in_subset: gosubset prok

negative regulation of transcription, DNA-templated
type: Class
subclass of: regulation of transcription, DNA-templated
subclass of: negative regulation of gene expression
subclass of: negative regulation of nucleic acid-templated transcription
subclass of: negative regulation of cellular macromolecule biosynthetic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
has_alternative_id: GO:0016481
has_alternative_id: GO:0032582
id: GO:0045892
has_alternative_id: GO:0061021
has_obo_namespace: biological_process
has_related_synonym: down regulation of gene-specific transcription
has_exact_synonym: down regulation of transcription, DNA-dependent
has_related_synonym: down-regulation of gene-specific transcription
has_exact_synonym: down-regulation of transcription, DNA-dependent
has_related_synonym: downregulation of gene-specific transcription
has_exact_synonym: downregulation of transcription, DNA-dependent
has_related_synonym: inhibition of gene-specific transcription
has_narrow_synonym: inhibition of transcription, DNA-dependent
has_exact_synonym: negative regulation of cellular transcription, DNA-dependent
has_related_synonym: negative regulation of gene-specific transcription
has_exact_synonym: negative regulation of transcription, DNA-dependent
has_related_synonym: transcription repressor activity
imported from: go.owl
in_subset: gosubset prok

negative regulation of nucleobase-containing compound metabolic process
type: Class
subclass of: regulation of nucleobase-containing compound metabolic process
subclass of: negative regulation of cellular metabolic process
subclass of: negative regulation of nitrogen compound metabolic process
definition: Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
id: GO:0045934
has_obo_namespace: biological_process
has_exact_synonym: down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
has_exact_synonym: down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
has_exact_synonym: downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
has_narrow_synonym: inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
has_related_synonym: negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
has_exact_synonym: negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
imported from: go.owl
in_subset: gosubset prok

negative regulation of glucosylceramide biosynthetic process
type: Class
subclass of: negative regulation of ceramide biosynthetic process
subclass of: regulation of ceramide biosynthetic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide.
id: GO:0046318
has_obo_namespace: biological_process
has_exact_synonym: down regulation of glucosylceramide biosynthetic process
has_exact_synonym: down-regulation of glucosylceramide biosynthetic process
has_exact_synonym: downregulation of glucosylceramide biosynthetic process
has_narrow_synonym: inhibition of glucosylceramide biosynthetic process
has_exact_synonym: negative regulation of glucosylceramide anabolism
has_exact_synonym: negative regulation of glucosylceramide biosynthesis
has_exact_synonym: negative regulation of glucosylceramide formation
has_exact_synonym: negative regulation of glucosylceramide synthesis
imported from: go.owl
in_subset: gosubset prok

regulation of lipid biosynthetic process
type: Class
subclass of: regulation of biosynthetic process
subclass of: regulation of lipid metabolic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.
id: GO:0046890
has_obo_namespace: biological_process
has_exact_synonym: regulation of lipid anabolism
has_exact_synonym: regulation of lipid biosynthesis
has_exact_synonym: regulation of lipid formation
has_exact_synonym: regulation of lipid synthesis
has_exact_synonym: regulation of lipogenesis
imported from: go.owl
in_subset: gosubset prok

organ development
type: Class
subclass of: anatomical structure development
subclass of: Restriction
  on property: part_of
  some values from: system development
imported from: oae.owl
imported from: uberon.owl

positive regulation of biological process
type: Class
subclass of: regulation of biological process
definition: Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
has_alternative_id: GO:0043119
id: GO:0048518
has_narrow_synonym: activation of biological process
has_obo_namespace: biological_process
has_exact_synonym: positive regulation of physiological process
has_narrow_synonym: stimulation of biological process
has_exact_synonym: up regulation of biological process
has_exact_synonym: up-regulation of biological process
has_exact_synonym: upregulation of biological process
imported from: go.owl
in_subset: gosubset prok

negative regulation of biological process
type: Class
subclass of: regulation of biological process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
has_alternative_id: GO:0043118
id: GO:0048519
has_obo_namespace: biological_process
has_exact_synonym: down regulation of biological process
has_exact_synonym: down-regulation of biological process
has_exact_synonym: downregulation of biological process
has_narrow_synonym: inhibition of biological process
has_exact_synonym: negative regulation of physiological process
imported from: go.owl
in_subset: gosubset prok

positive regulation of cellular process
type: Class
subclass of: positive regulation of biological process
subclass of: regulation of cellular process
definition: Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
id: GO:0048522
has_alternative_id: GO:0051242
has_narrow_synonym: activation of cellular process
has_obo_namespace: biological_process
has_exact_synonym: positive regulation of cellular physiological process
has_narrow_synonym: stimulation of cellular process
has_exact_synonym: up regulation of cellular process
has_exact_synonym: up-regulation of cellular process
has_exact_synonym: upregulation of cellular process
imported from: go.owl
in_subset: gosubset prok

negative regulation of cellular process
type: Class
subclass of: negative regulation of biological process
subclass of: regulation of cellular process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
id: GO:0048523
has_alternative_id: GO:0051243
has_obo_namespace: biological_process
has_exact_synonym: down regulation of cellular process
has_exact_synonym: down-regulation of cellular process
has_exact_synonym: downregulation of cellular process
has_narrow_synonym: inhibition of cellular process
has_exact_synonym: negative regulation of cellular physiological process
imported from: go.owl
in_subset: gosubset prok

regulation of response to stimulus
type: Class
subclass of: regulation of biological process
definition: Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
id: GO:0048583
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
has_obo_namespace: biological_process
imported from: go.owl
in_subset: gocheck do not manually annotate
in_subset: gosubset prok

positive regulation of response to stimulus
type: Class
subclass of: positive regulation of biological process
subclass of: regulation of response to stimulus
definition: Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
id: GO:0048584
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
has_narrow_synonym: activation of response to stimulus
has_obo_namespace: biological_process
has_narrow_synonym: stimulation of response to stimulus
has_exact_synonym: up regulation of response to stimulus
has_exact_synonym: up-regulation of response to stimulus
has_exact_synonym: upregulation of response to stimulus
imported from: go.owl
in_subset: gocheck do not manually annotate

negative regulation of response to stimulus
type: Class
subclass of: negative regulation of biological process
subclass of: regulation of response to stimulus
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
id: GO:0048585
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
has_obo_namespace: biological_process
has_exact_synonym: down regulation of response to stimulus
has_exact_synonym: down-regulation of response to stimulus
has_exact_synonym: downregulation of response to stimulus
has_narrow_synonym: inhibition of response to stimulus
imported from: go.owl
in_subset: gocheck do not manually annotate

embryonic morphogenesis
type: Class
subclass of: anatomical structure morphogenesis
subclass of: single-organism developmental process
subclass of: Restriction
  on property: part_of
  some values from: embryo development
imported from: oae.owl
imported from: uberon.owl

anatomical structure formation involved in morphogenesis
type: Class
subclass of: developmental process
subclass of: Restriction
  on property: part_of
  some values from: anatomical structure morphogenesis
imported from: oae.owl
imported from: uberon.owl

tissue morphogenesis
type: Class
subclass of: anatomical structure morphogenesis
subclass of: single-organism developmental process
subclass of: Restriction
  on property: part_of
  some values from: tissue development
imported from: oae.owl
imported from: uberon.owl

system development
type: Class
subclass of: anatomical structure development
subclass of: Restriction
  on property: part_of
  some values from: multicellular organismal development
imported from: go.owl
imported from: oae.owl
imported from: uberon.owl

anatomical structure development
type: Class
subclass of: developmental process
imported from: go.owl
imported from: oae.owl
imported from: uberon.owl
in_subset: goslim generic

regulation of catecholamine secretion
type: Class
subclass of: regulation of amine transport
subclass of: regulation of secretion by cell
definition: Any process that modulates the frequency, rate or extent of the regulated release of catecholamines.
id: GO:0050433
has_obo_namespace: biological_process
imported from: go.owl

regulation of biological process
type: Class
subclass of: biological regulation
definition: Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
id: GO:0050789
has_alternative_id: GO:0050791
has_obo_namespace: biological_process
has_exact_synonym: regulation of physiological process
imported from: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: gosubset prok

regulation of catalytic activity
type: Class
subclass of: regulation of metabolic process
subclass of: regulation of molecular function
definition: Any process that modulates the activity of an enzyme.
id: GO:0050790
has_obo_namespace: biological_process
has_exact_synonym: regulation of enzyme activity
imported from: go.owl
in_subset: gosubset prok

regulation of cellular process
type: Class
subclass of: regulation of biological process
definition: Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
id: GO:0050794
has_alternative_id: GO:0051244
has_obo_namespace: biological_process
has_exact_synonym: regulation of cellular physiological process
imported from: go.owl
in_subset: gosubset prok

regulation of synaptic transmission
type: Class
subclass of: regulation of cell communication
subclass of: regulation of signaling
subclass of: biological regulation
definition: Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
id: GO:0050804
has_obo_namespace: biological_process
imported from: go.owl

negative regulation of synaptic transmission
type: Class
subclass of: negative regulation of cell communication
subclass of: negative regulation of signaling
subclass of: regulation of synaptic transmission
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
id: GO:0050805
has_obo_namespace: biological_process
has_exact_synonym: down regulation of synaptic transmission
has_exact_synonym: down-regulation of synaptic transmission
has_exact_synonym: downregulation of synaptic transmission
has_narrow_synonym: inhibition of synaptic transmission
imported from: go.owl

neurological system process
type: Class
subclass of: system process
imported from: go.owl
imported from: oae.owl
imported from: uberon.owl
in_subset: goslim generic
in_subset: goslim pir

response to stimulus
type: Class
subclass of: biological_process
imported from: go.owl
imported from: oae.owl
imported from: uberon.owl
in_subset: goslim pir
in_subset: gosubset prok
in_subset: high level annotation qc

detection of stimulus involved in sensory perception
type: Class
equivalent class: Class
  intersection of: detection of stimulus
  intersection of: Restriction
    on property: part_of
    some values from: sensory perception
subclass of: detection of stimulus
subclass of: Restriction
  on property: part_of
  some values from: sensory perception
imported from: oae.owl
imported from: uberon.owl

sensory perception of light stimulus
type: Class
subclass of: sensory perception
imported from: oae.owl
imported from: uberon.owl

regulation of secretion
type: Class
subclass of: regulation of transport
definition: Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.
id: GO:0051046
has_obo_namespace: biological_process
imported from: go.owl
in_subset: gosubset prok

negative regulation of secretion
type: Class
subclass of: regulation of secretion
subclass of: negative regulation of transport
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.
id: GO:0051048
has_obo_namespace: biological_process
has_exact_synonym: down regulation of secretion
has_exact_synonym: down-regulation of secretion
has_exact_synonym: downregulation of secretion
has_narrow_synonym: inhibition of secretion
imported from: go.owl

regulation of transport
type: Class
subclass of: regulation of localization
definition: Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
id: GO:0051049
has_obo_namespace: biological_process
imported from: go.owl
in_subset: goslim yeast
in_subset: gosubset prok

negative regulation of transport
type: Class
subclass of: negative regulation of biological process
subclass of: regulation of transport
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
id: GO:0051051
has_obo_namespace: biological_process
has_exact_synonym: down regulation of transport
has_exact_synonym: down-regulation of transport
has_exact_synonym: downregulation of transport
has_narrow_synonym: inhibition of transport
imported from: go.owl
in_subset: gosubset prok

negative regulation of lipid biosynthetic process
type: Class
subclass of: negative regulation of biosynthetic process
subclass of: negative regulation of lipid metabolic process
subclass of: regulation of lipid biosynthetic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.
id: GO:0051055
has_obo_namespace: biological_process
has_exact_synonym: down regulation of lipid biosynthetic process
has_exact_synonym: down-regulation of lipid biosynthetic process
has_exact_synonym: downregulation of lipid biosynthetic process
has_narrow_synonym: inhibition of lipid biosynthetic process
has_exact_synonym: negative regulation of lipid anabolism
has_exact_synonym: negative regulation of lipid biosynthesis
has_exact_synonym: negative regulation of lipid formation
has_exact_synonym: negative regulation of lipid synthesis
has_exact_synonym: negative regulation of lipogenesis
imported from: go.owl
in_subset: gosubset prok

regulation of sequence-specific DNA binding transcription factor activity
type: Class
subclass of: regulation of transcription, DNA-templated
subclass of: regulation of molecular function
definition: Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
id: GO:0051090
database_cross_reference: Reactome:REACT_104536
database_cross_reference: Reactome:REACT_107559
database_cross_reference: Reactome:REACT_109535
database_cross_reference: Reactome:REACT_110257
database_cross_reference: Reactome:REACT_110693
database_cross_reference: Reactome:REACT_21326
database_cross_reference: Reactome:REACT_82719
database_cross_reference: Reactome:REACT_83365
database_cross_reference: Reactome:REACT_90659
database_cross_reference: Reactome:REACT_92725
database_cross_reference: Reactome:REACT_96476
database_cross_reference: Reactome:REACT_99415
has_obo_namespace: biological_process
has_broad_synonym: regulation of transcription factor activity
imported from: go.owl
in_subset: gosubset prok

regulation of nitrogen compound metabolic process
type: Class
subclass of: regulation of metabolic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds.
id: GO:0051171
has_obo_namespace: biological_process
has_exact_synonym: regulation of nitrogen metabolic process
has_exact_synonym: regulation of nitrogen metabolism
imported from: go.owl
in_subset: gosubset prok

negative regulation of nitrogen compound metabolic process
type: Class
subclass of: negative regulation of metabolic process
subclass of: regulation of nitrogen compound metabolic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds.
id: GO:0051172
has_obo_namespace: biological_process
has_exact_synonym: down regulation of nitrogen metabolic process
has_exact_synonym: down-regulation of nitrogen metabolic process
has_exact_synonym: downregulation of nitrogen metabolic process
has_narrow_synonym: inhibition of nitrogen metabolic process
has_exact_synonym: negative regulation of nitrogen metabolic process
has_exact_synonym: negative regulation of nitrogen metabolism
imported from: go.owl

regulation of RNA metabolic process
type: Class
subclass of: regulation of nucleobase-containing compound metabolic process
subclass of: regulation of macromolecule metabolic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.
id: GO:0051252
has_obo_namespace: biological_process
has_exact_synonym: regulation of RNA metabolism
imported from: go.owl
in_subset: gosubset prok

negative regulation of RNA metabolic process
type: Class
subclass of: negative regulation of macromolecule metabolic process
subclass of: negative regulation of nucleobase-containing compound metabolic process
subclass of: regulation of RNA metabolic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA.
id: GO:0051253
has_obo_namespace: biological_process
has_exact_synonym: down regulation of RNA metabolic process
has_exact_synonym: down-regulation of RNA metabolic process
has_exact_synonym: downregulation of RNA metabolic process
has_narrow_synonym: inhibition of RNA metabolic process
has_exact_synonym: negative regulation of RNA metabolism
imported from: go.owl
in_subset: gosubset prok

cell division
type: Class
subclass of: single-organism cellular process
imported from: oae.owl
imported from: uberon.owl

regulation of hydrolase activity
type: Class
subclass of: regulation of catalytic activity
definition: Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
id: GO:0051336
has_obo_namespace: biological_process
has_exact_synonym: hydrolase regulator
imported from: go.owl
in_subset: gosubset prok

regulation of oxidoreductase activity
type: Class
subclass of: regulation of catalytic activity
definition: Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
id: GO:0051341
has_obo_namespace: biological_process
has_exact_synonym: oxidoreductase regulator
imported from: go.owl
in_subset: gosubset prok

negative regulation of cyclic-nucleotide phosphodiesterase activity
type: Class
subclass of: regulation of hydrolase activity
subclass of: negative regulation of hydrolase activity
has_exact_synonym: 3',5' cyclic nucleotide phosphodiesterase inhibitor
has_narrow_synonym: 3',5'-cyclic-AMP phosphodiesterase inhibitor
definition: Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate.
id: GO:0051344
has_obo_namespace: biological_process
has_narrow_synonym: cAMP phosphodiesterase inhibitor
has_exact_synonym: down regulation of cyclic nucleotide phosphodiesterase activity
has_exact_synonym: down-regulation of cyclic nucleotide phosphodiesterase activity
has_exact_synonym: downregulation of cyclic nucleotide phosphodiesterase activity
has_narrow_synonym: inhibition of cyclic nucleotide phosphodiesterase activity
has_exact_synonym: negative regulation of 3',5' cyclic nucleotide phosphodiesterase activity
has_narrow_synonym: negative regulation of 3',5'-cyclic-AMP phosphodiesterase activity
has_narrow_synonym: negative regulation of cAMP phosphodiesterase activity
has_narrow_synonym: negative regulation of cGMP phosphodiesterase activity
has_exact_synonym: negative regulation of cyclic nucleotide phosphodiesterase activity
has_related_synonym: phosphodiesterase inhibitor
imported from: go.owl

negative regulation of hydrolase activity
type: Class
subclass of: negative regulation of catalytic activity
subclass of: regulation of hydrolase activity
definition: Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds.
id: GO:0051346
has_obo_namespace: biological_process
has_exact_synonym: down regulation of hydrolase activity
has_exact_synonym: down-regulation of hydrolase activity
has_exact_synonym: downregulation of hydrolase activity
has_exact_synonym: hydrolase inhibitor
has_narrow_synonym: inhibition of hydrolase activity
imported from: go.owl
in_subset: gosubset prok

negative regulation of oxidoreductase activity
type: Class
subclass of: negative regulation of catalytic activity
subclass of: regulation of oxidoreductase activity
definition: Any process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered.
id: GO:0051354
has_obo_namespace: biological_process
has_exact_synonym: down regulation of oxidoreductase activity
has_exact_synonym: down-regulation of oxidoreductase activity
has_exact_synonym: downregulation of oxidoreductase activity
has_narrow_synonym: inhibition of oxidoreductase activity
has_exact_synonym: oxidoreductase inhibitor
imported from: go.owl
in_subset: gosubset prok

regulation of neurotransmitter uptake
type: Class
subclass of: regulation of synaptic transmission
subclass of: regulation of neurotransmitter transport
definition: Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell.
id: GO:0051580
has_obo_namespace: biological_process
has_exact_synonym: regulation of neurotransmitter import
has_exact_synonym: regulation of neurotransmitter reuptake
imported from: go.owl

negative regulation of neurotransmitter uptake
type: Class
subclass of: negative regulation of synaptic transmission
subclass of: regulation of neurotransmitter uptake
subclass of: negative regulation of neurotransmitter transport
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell.
id: GO:0051581
has_obo_namespace: biological_process
has_exact_synonym: down regulation of neurotransmitter uptake
has_exact_synonym: down-regulation of neurotransmitter uptake
has_exact_synonym: downregulation of neurotransmitter uptake
has_exact_synonym: negative regulation of neurotransmitter import
imported from: go.owl

regulation of dopamine uptake involved in synaptic transmission
type: Class
subclass of: regulation of synaptic transmission, dopaminergic
subclass of: regulation of ion transport
subclass of: regulation of anion transport
subclass of: regulation of catecholamine uptake involved in synaptic transmission
definition: Any process that modulates the frequency, rate or extent of the directed movement of the catecholamine neurotransmitter dopamine into a cell.
id: GO:0051584
has_obo_namespace: biological_process
has_exact_synonym: regulation of dopamine import involved in synaptic transmission
imported from: go.owl

negative regulation of dopamine uptake involved in synaptic transmission
type: Class
subclass of: negative regulation of synaptic transmission, dopaminergic
subclass of: regulation of dopamine uptake involved in synaptic transmission
subclass of: negative regulation of catecholamine uptake involved in synaptic transmission
subclass of: negative regulation of anion transport
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of dopamine into a presynaptic neuron or glial cell.
id: GO:0051585
has_obo_namespace: biological_process
has_exact_synonym: down regulation of dopamine uptake involved in synaptic transmission
has_exact_synonym: down-regulation of dopamine uptake involved in synaptic transmission
has_exact_synonym: downregulation of dopamine uptake involved in synaptic transmission
has_exact_synonym: negative regulation of dopamine import involved in synaptic transmission
imported from: go.owl

regulation of neurotransmitter transport
type: Class
subclass of: regulation of transport
definition: Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
id: GO:0051588
has_obo_namespace: biological_process
imported from: go.owl

negative regulation of neurotransmitter transport
type: Class
subclass of: negative regulation of transport
subclass of: regulation of neurotransmitter transport
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
id: GO:0051589
has_obo_namespace: biological_process
has_exact_synonym: down regulation of neurotransmitter transport
has_exact_synonym: down-regulation of neurotransmitter transport
has_exact_synonym: downregulation of neurotransmitter transport
has_narrow_synonym: inhibition of neurotransmitter transport
imported from: go.owl

detection of stimulus
type: Class
subclass of: response to stimulus
imported from: oae.owl
imported from: uberon.owl

regulation of serotonin uptake
type: Class
subclass of: regulation of ion transport
subclass of: regulation of anion transport
subclass of: regulation of neurotransmitter uptake
definition: Any process that modulates the frequency, rate or extent of the directed movement of the monoamine neurotransmitter serotonin into a cell.
id: GO:0051611
has_obo_namespace: biological_process
has_exact_synonym: regulation of 5-HT uptake
has_exact_synonym: regulation of 5-hydroxytryptamine uptake
has_exact_synonym: regulation of 5HT uptake
has_exact_synonym: regulation of serotonin import
imported from: go.owl

negative regulation of serotonin uptake
type: Class
subclass of: negative regulation of neurotransmitter uptake
subclass of: regulation of serotonin uptake
subclass of: negative regulation of anion transport
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of serotonin into a cell.
id: GO:0051612
has_obo_namespace: biological_process
has_exact_synonym: down regulation of serotonin uptake
has_exact_synonym: down-regulation of serotonin uptake
has_exact_synonym: downregulation of serotonin uptake
has_exact_synonym: negative regulation of 5-HT uptake
has_exact_synonym: negative regulation of 5-hydroxytryptamine uptake
has_exact_synonym: negative regulation of 5HT uptake
has_exact_synonym: negative regulation of serotonin import
imported from: go.owl

negative regulation of norepinephrine uptake
type: Class
subclass of: regulation of catecholamine uptake involved in synaptic transmission
subclass of: negative regulation of catecholamine uptake involved in synaptic transmission
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell.
id: GO:0051622
has_obo_namespace: biological_process
has_exact_synonym: down regulation of norepinephrine uptake
has_exact_synonym: down-regulation of norepinephrine uptake
has_exact_synonym: downregulation of norepinephrine uptake
has_exact_synonym: negative regulation of levarterenol uptake
has_exact_synonym: negative regulation of noradrenaline uptake
has_exact_synonym: negative regulation of norepinephrine import
imported from: go.owl

inhibition of norepinephrine uptake
type: Class
subclass of: negative regulation of neurotransmitter uptake
subclass of: negative regulation of norepinephrine uptake
definition: Any process that prevents the activation of the directed movement of norepinephrine into a cell.
id: GO:0051624
has_obo_namespace: biological_process
has_exact_synonym: inhibition of levarterenol uptake
has_exact_synonym: inhibition of noradrenaline uptake
has_exact_synonym: inhibition of norepinephrine import
imported from: go.owl

negative regulation of calcium ion transport
type: Class
subclass of: regulation of ion transport
subclass of: negative regulation of ion transport
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
id: GO:0051926
has_obo_namespace: biological_process
has_exact_synonym: down regulation of calcium ion transport
has_exact_synonym: down-regulation of calcium ion transport
has_exact_synonym: downregulation of calcium ion transport
has_narrow_synonym: inhibition of calcium ion transport
has_exact_synonym: negative regulation of calcium transport
imported from: go.owl

regulation of catecholamine uptake involved in synaptic transmission
type: Class
subclass of: regulation of neurotransmitter uptake
subclass of: regulation of amine transport
definition: Any process that modulates the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell.
id: GO:0051940
has_obo_namespace: biological_process
has_exact_synonym: regulation of catecholamine neurotransmitter reuptake
has_exact_synonym: regulation of catecholamine neurotransmitter uptake
has_broad_synonym: regulation of catecholamine uptake during transmission of nerve impulse
imported from: go.owl

negative regulation of catecholamine uptake involved in synaptic transmission
type: Class
subclass of: negative regulation of neurotransmitter uptake
subclass of: regulation of catecholamine uptake involved in synaptic transmission
subclass of: negative regulation of amine transport
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell.
id: GO:0051945
has_obo_namespace: biological_process
has_exact_synonym: down regulation of catecholamine uptake during transmission of nerve impulse
has_exact_synonym: down-regulation of catecholamine uptake during transmission of nerve impulse
has_exact_synonym: downregulation of catecholamine uptake during transmission of nerve impulse
has_narrow_synonym: inhibition of catecholamine uptake during transmission of nerve impulse
has_exact_synonym: negative regulation of catecholamine neurotransmitter reuptake
has_exact_synonym: negative regulation of catecholamine neurotransmitter uptake
has_broad_synonym: negative regulation of catecholamine uptake during transmission of nerve impulse
imported from: go.owl

regulation of amine transport
type: Class
subclass of: regulation of transport
definition: Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
id: GO:0051952
has_obo_namespace: biological_process
imported from: go.owl

negative regulation of amine transport
type: Class
subclass of: negative regulation of transport
subclass of: regulation of amine transport
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
id: GO:0051953
has_obo_namespace: biological_process
has_exact_synonym: down regulation of amine transport
has_exact_synonym: down-regulation of amine transport
has_exact_synonym: downregulation of amine transport
has_narrow_synonym: inhibition of amine transport
imported from: go.owl

regulation of macromolecule metabolic process
type: Class
subclass of: regulation of metabolic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
id: GO:0060255
has_obo_namespace: biological_process
imported from: go.owl
in_subset: gosubset prok

regulation of cellular localization
type: Class
subclass of: regulation of localization
subclass of: regulation of cellular process
definition: Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell.
id: GO:0060341
has_obo_namespace: biological_process
has_exact_synonym: regulation of cellular localisation
imported from: go.owl

epithelium development
type: Class
subclass of: tissue development
imported from: oae.owl
imported from: uberon.owl

epithelial tube morphogenesis
type: Class
subclass of: morphogenesis of an epithelium
subclass of: tube morphogenesis
imported from: oae.owl
imported from: uberon.owl

regulation of response to cytokine stimulus
type: Class
subclass of: regulation of response to stimulus
creation date: 2009-06-22T02:56:12Z
definition: Any process that modulates the rate, frequency, or extent of a response to cytokine stimulus.
id: GO:0060759
has_obo_namespace: biological_process
created by: dph
imported from: go.owl

negative regulation of response to cytokine stimulus
type: Class
subclass of: negative regulation of response to stimulus
subclass of: regulation of response to cytokine stimulus
creation date: 2009-06-22T02:59:57Z
definition: Any process that decreases the rate, frequency, or extent of a response to cytokine stimulus.
id: GO:0060761
has_obo_namespace: biological_process
created by: dph
imported from: go.owl

regulation of androgen receptor signaling pathway
type: Class
subclass of: regulation of intracellular steroid hormone receptor signaling pathway
creation date: 2009-07-06T11:07:38Z
definition: Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway.
id: GO:0060765
has_obo_namespace: biological_process
created by: dph
has_exact_synonym: regulation of androgen receptor signalling pathway
imported from: go.owl

negative regulation of androgen receptor signaling pathway
type: Class
subclass of: negative regulation of intracellular steroid hormone receptor signaling pathway
subclass of: regulation of androgen receptor signaling pathway
creation date: 2009-07-06T11:09:36Z
definition: Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway.
id: GO:0060766
has_obo_namespace: biological_process
created by: dph
has_exact_synonym: negative regulation of androgen receptor signalling pathway
imported from: go.owl

biological regulation
type: Class
subclass of: biological_process
definition: Any process that modulates a measurable attribute of any biological process, quality or function.
id: GO:0065007
has_obo_namespace: biological_process
has_broad_synonym: regulation
imported from: go.owl
in_subset: goslim pir
in_subset: gosubset prok

regulation of molecular function
type: Class
subclass of: biological regulation
definition: Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
id: GO:0065009
has_obo_namespace: biological_process
has_exact_synonym: regulation of a molecular function
imported from: go.owl
in_subset: gosubset prok

epithelial tube formation
type: Class
subclass of: tube formation
subclass of: Restriction
  on property: part_of
  some values from: epithelial tube morphogenesis
imported from: oae.owl
imported from: uberon.owl

regulation of primary metabolic process
type: Class
subclass of: regulation of metabolic process
creation date: 2009-04-22T04:30:52Z
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
id: GO:0080090
has_obo_namespace: biological_process
created by: donghui
imported from: go.owl

regulation of sphingolipid biosynthetic process
type: Class
subclass of: regulation of macromolecule biosynthetic process
subclass of: regulation of cellular biosynthetic process
subclass of: regulation of lipid biosynthetic process
subclass of: regulation of biological process
subclass of: regulation of nitrogen compound metabolic process
creation date: 2009-12-08T03:25:49Z
definition: Any process that modulates the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
id: GO:0090153
has_obo_namespace: biological_process
created by: tanyaberardini
imported from: go.owl

negative regulation of sphingolipid biosynthetic process
type: Class
subclass of: negative regulation of cellular biosynthetic process
subclass of: negative regulation of lipid biosynthetic process
subclass of: negative regulation of nitrogen compound metabolic process
subclass of: regulation of sphingolipid biosynthetic process
creation date: 2009-12-08T03:33:39Z
definition: Any process that decreases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
id: GO:0090155
has_obo_namespace: biological_process
created by: tanyaberardini
imported from: go.owl

negative regulation of ceramide biosynthetic process
type: Class
subclass of: negative regulation of cellular amide metabolic process
subclass of: negative regulation of sphingolipid biosynthetic process
subclass of: regulation of ceramide biosynthetic process
creation date: 2012-01-25T03:18:07Z
definition: Any process that stops, prevents or reduces the frequency, rate or extent of a ceramide biosynthetic process.
id: GO:1900060
has_obo_namespace: biological_process
has_exact_synonym: down regulation of ceramide anabolism
has_exact_synonym: down regulation of ceramide biosynthesis
has_related_synonym: down regulation of ceramide biosynthetic process
has_exact_synonym: down regulation of ceramide formation
has_exact_synonym: down regulation of ceramide synthesis
has_exact_synonym: down-regulation of ceramide anabolism
has_exact_synonym: down-regulation of ceramide biosynthesis
has_related_synonym: down-regulation of ceramide biosynthetic process
has_exact_synonym: down-regulation of ceramide formation
has_exact_synonym: down-regulation of ceramide synthesis
has_exact_synonym: downregulation of ceramide anabolism
has_exact_synonym: downregulation of ceramide biosynthesis
has_related_synonym: downregulation of ceramide biosynthetic process
has_exact_synonym: downregulation of ceramide formation
has_exact_synonym: downregulation of ceramide synthesis
created by: dph
has_exact_synonym: inhibition of ceramide anabolism
has_exact_synonym: inhibition of ceramide biosynthesis
has_related_synonym: inhibition of ceramide biosynthetic process
has_exact_synonym: inhibition of ceramide formation
has_exact_synonym: inhibition of ceramide synthesis
has_exact_synonym: negative regulation of ceramide anabolism
has_exact_synonym: negative regulation of ceramide biosynthesis
has_exact_synonym: negative regulation of ceramide formation
has_exact_synonym: negative regulation of ceramide synthesis
imported from: go.owl

regulation of cellular response to insulin stimulus
type: Class
subclass of: regulation of response to stimulus
subclass of: regulation of cellular process
creation date: 2012-01-31T11:22:22Z
definition: Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus.
id: GO:1900076
has_obo_namespace: biological_process
created by: yaf
imported from: go.owl

positive regulation of cellular response to insulin stimulus
type: Class
subclass of: positive regulation of cellular process
subclass of: positive regulation of response to stimulus
subclass of: regulation of cellular response to insulin stimulus
creation date: 2012-01-31T11:24:30Z
definition: Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus.
id: GO:1900078
has_narrow_synonym: activation of cellular response to insulin stimulus
has_obo_namespace: biological_process
has_exact_synonym: up regulation of cellular response to insulin stimulus
has_exact_synonym: up-regulation of cellular response to insulin stimulus
has_exact_synonym: upregulation of cellular response to insulin stimulus
created by: yaf
imported from: go.owl

negative regulation of RNA biosynthetic process
type: Class
subclass of: negative regulation of macromolecule biosynthetic process
subclass of: negative regulation of cellular biosynthetic process
subclass of: negative regulation of RNA metabolic process
subclass of: regulation of RNA biosynthetic process
creation date: 2014-02-05T16:32:01Z
definition: Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process.
id: GO:1902679
has_obo_namespace: biological_process
has_exact_synonym: down regulation of RNA anabolism
has_exact_synonym: down regulation of RNA biosynthesis
has_exact_synonym: down regulation of RNA biosynthetic process
has_exact_synonym: down regulation of RNA formation
has_exact_synonym: down regulation of RNA synthesis
has_exact_synonym: down-regulation of RNA anabolism
has_exact_synonym: down-regulation of RNA biosynthesis
has_exact_synonym: down-regulation of RNA biosynthetic process
has_exact_synonym: down-regulation of RNA formation
has_exact_synonym: down-regulation of RNA synthesis
has_exact_synonym: downregulation of RNA anabolism
has_exact_synonym: downregulation of RNA biosynthesis
has_exact_synonym: downregulation of RNA biosynthetic process
has_exact_synonym: downregulation of RNA formation
has_exact_synonym: downregulation of RNA synthesis
has_narrow_synonym: inhibition of RNA anabolism
has_narrow_synonym: inhibition of RNA biosynthesis
has_narrow_synonym: inhibition of RNA biosynthetic process
has_narrow_synonym: inhibition of RNA formation
has_narrow_synonym: inhibition of RNA synthesis
created by: jl
has_exact_synonym: negative regulation of RNA anabolism
has_exact_synonym: negative regulation of RNA biosynthesis
has_exact_synonym: negative regulation of RNA formation
has_exact_synonym: negative regulation of RNA synthesis
imported from: go.owl

regulation of nucleic acid-templated transcription
type: Class
subclass of: regulation of RNA biosynthetic process
creation date: 2014-10-01T14:44:47Z
definition: Any process that modulates the frequency, rate or extent of nucleic acid-templated transcription.
id: GO:1903506
has_obo_namespace: biological_process
created by: pr
imported from: go.owl

negative regulation of nucleic acid-templated transcription
type: Class
subclass of: negative regulation of RNA biosynthetic process
subclass of: regulation of nucleic acid-templated transcription
creation date: 2014-10-01T14:44:56Z
definition: Any process that stops, prevents or reduces the frequency, rate or extent of nucleic acid-templated transcription.
id: GO:1903507
has_obo_namespace: biological_process
has_exact_synonym: down regulation of nucleic acid-templated transcription
has_exact_synonym: down-regulation of nucleic acid-templated transcription
has_exact_synonym: downregulation of nucleic acid-templated transcription
has_narrow_synonym: inhibition of nucleic acid-templated transcription
created by: pr
imported from: go.owl

regulation of secretion by cell
type: Class
subclass of: regulation of secretion
subclass of: regulation of cellular localization
creation date: 2014-10-08T13:24:59Z
definition: Any process that modulates the frequency, rate or extent of secretion by cell.
id: GO:1903530
has_obo_namespace: biological_process
created by: pm
has_exact_synonym: regulation of cellular secretion
imported from: go.owl

negative regulation of secretion by cell
type: Class
subclass of: negative regulation of cellular process
subclass of: negative regulation of secretion
subclass of: regulation of secretion by cell
creation date: 2014-10-08T13:25:08Z
definition: Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell.
id: GO:1903531
has_obo_namespace: biological_process
has_exact_synonym: down regulation of cellular secretion
has_exact_synonym: down regulation of secretion by cell
has_exact_synonym: down-regulation of cellular secretion
has_exact_synonym: down-regulation of secretion by cell
has_exact_synonym: downregulation of cellular secretion
has_exact_synonym: downregulation of secretion by cell
has_narrow_synonym: inhibition of cellular secretion
has_narrow_synonym: inhibition of secretion by cell
has_exact_synonym: negative regulation of cellular secretion
created by: pm
imported from: go.owl

negative regulation of anion transport
type: Class
subclass of: negative regulation of ion transport
subclass of: regulation of anion transport
creation date: 2015-01-12T21:50:20Z
definition: Any process that stops, prevents or reduces the frequency, rate or extent of anion transport.
id: GO:1903792
has_obo_namespace: biological_process
has_exact_synonym: down regulation of anion transport
has_exact_synonym: down-regulation of anion transport
has_exact_synonym: downregulation of anion transport
has_narrow_synonym: inhibition of anion transport
created by: sl
imported from: go.owl

regulation of cellular macromolecule biosynthetic process
type: Class
subclass of: regulation of macromolecule biosynthetic process
subclass of: regulation of cellular biosynthetic process
creation date: 2010-09-15T08:55:45Z
definition: Any process that modulates the frequency, rate or extent of cellular macromolecule biosynthetic process.
id: GO:2000112
has_obo_namespace: biological_process
has_exact_synonym: regulation of cellular biopolymer biosynthetic process
has_exact_synonym: regulation of cellular macromolecule anabolism
has_exact_synonym: regulation of cellular macromolecule biosynthesis
has_exact_synonym: regulation of cellular macromolecule formation
has_exact_synonym: regulation of cellular macromolecule synthesis
created by: tanyaberardini
imported from: go.owl

negative regulation of cellular macromolecule biosynthetic process
type: Class
subclass of: negative regulation of macromolecule biosynthetic process
subclass of: negative regulation of cellular biosynthetic process
subclass of: regulation of cellular macromolecule biosynthetic process
creation date: 2010-09-15T08:55:48Z
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of cellular macromolecule biosynthetic process.
id: GO:2000113
has_obo_namespace: biological_process
has_exact_synonym: negative regulation of cellular biopolymer biosynthetic process
has_exact_synonym: negative regulation of cellular macromolecule anabolism
has_exact_synonym: negative regulation of cellular macromolecule biosynthesis
has_exact_synonym: negative regulation of cellular macromolecule formation
has_exact_synonym: negative regulation of cellular macromolecule synthesis
created by: tanyaberardini
imported from: go.owl

negative regulation of receptor activity
type: Class
subclass of: regulation of receptor activity
subclass of: negative regulation of molecular function
creation date: 2010-12-02T09:28:47Z
definition: Any process that stops, prevents or reduces the frequency, rate or extent of receptor activity.
id: GO:2000272
has_obo_namespace: biological_process
created by: rfoulger
imported from: go.owl

regulation of ceramide biosynthetic process
type: Class
subclass of: regulation of cellular amide metabolic process
subclass of: regulation of sphingolipid biosynthetic process
creation date: 2011-01-04T02:37:12Z
definition: Any process that modulates the frequency, rate or extent of a ceramide biosynthetic process.
id: GO:2000303
has_obo_namespace: biological_process
created by: dph
has_exact_synonym: regulation of ceramide anabolism
has_exact_synonym: regulation of ceramide biosynthesis
has_exact_synonym: regulation of ceramide formation
has_exact_synonym: regulation of ceramide synthesis
imported from: go.owl

regulation of DNA topoisomerase (ATP-hydrolyzing) activity
type: Class
subclass of: regulation of ATPase activity
subclass of: regulation of catalytic activity
creation date: 2011-02-09T02:35:27Z
definition: Any process that modulates the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity.
id: GO:2000371
has_obo_namespace: biological_process
created by: midori
has_exact_synonym: regulation of DNA gyrase activity
has_related_synonym: regulation of DNA topoisomerase (ATP-hydrolysing)
has_related_synonym: regulation of DNA topoisomerase II
has_exact_synonym: regulation of DNA topoisomerase IV activity
has_exact_synonym: regulation of DNA topoisomerase type II activity
has_exact_synonym: regulation of DNA-gyrase activity
has_related_synonym: regulation of deoxyribonucleate topoisomerase
has_exact_synonym: regulation of deoxyribonucleic topoisomerase activity
has_related_synonym: regulation of topoisomerase
has_exact_synonym: regulation of topoisomerase II
has_exact_synonym: regulation of type II DNA topoisomerase activity
imported from: go.owl

negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity
type: Class
subclass of: negative regulation of ATPase activity
subclass of: regulation of DNA topoisomerase (ATP-hydrolyzing) activity
creation date: 2011-02-09T02:35:36Z
definition: Any process that stops, prevents or reduces the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity.
id: GO:2000372
has_obo_namespace: biological_process
created by: midori
has_exact_synonym: negative regulation of DNA gyrase activity
has_related_synonym: negative regulation of DNA topoisomerase (ATP-hydrolysing)
has_related_synonym: negative regulation of DNA topoisomerase II
has_exact_synonym: negative regulation of DNA topoisomerase IV activity
has_exact_synonym: negative regulation of DNA topoisomerase type II activity
has_exact_synonym: negative regulation of DNA-gyrase activity
has_related_synonym: negative regulation of deoxyribonucleate topoisomerase
has_exact_synonym: negative regulation of deoxyribonucleic topoisomerase activity
has_related_synonym: negative regulation of topoisomerase
has_exact_synonym: negative regulation of topoisomerase II
has_exact_synonym: negative regulation of type II DNA topoisomerase activity
imported from: go.owl

positive regulation of opioid receptor signaling pathway
type: Class
subclass of: regulation of G-protein coupled receptor protein signaling pathway
subclass of: positive regulation of G-protein coupled receptor protein signaling pathway
creation date: 2011-03-09T09:41:35Z
definition: Any process that activates or increases the frequency, rate or extent of opioid receptor signaling pathway.
id: GO:2000476
has_obo_namespace: biological_process
has_exact_synonym: positive regulation of opioid receptor signalling pathway
created by: rfoulger
imported from: go.owl

regulation of androgen receptor activity
type: Class
subclass of: regulation of transcription from RNA polymerase II promoter
subclass of: regulation of receptor activity
subclass of: regulation of sequence-specific DNA binding transcription factor activity
subclass of: regulation of androgen receptor signaling pathway
creation date: 2011-07-15T10:56:08Z
definition: Any process that modulates the frequency, rate or extent of androgen receptor activity.
id: GO:2000823
has_obo_namespace: biological_process
created by: yaf
imported from: go.owl

negative regulation of androgen receptor activity
type: Class
subclass of: negative regulation of transcription from RNA polymerase II promoter
subclass of: negative regulation of sequence-specific DNA binding transcription factor activity
subclass of: negative regulation of androgen receptor signaling pathway
subclass of: negative regulation of receptor activity
subclass of: regulation of androgen receptor activity
creation date: 2011-07-15T10:56:12Z
definition: Any process that stops, prevents or reduces the frequency, rate or extent of androgen receptor activity.
id: GO:2000824
has_obo_namespace: biological_process
created by: yaf
imported from: go.owl

regulation of RNA biosynthetic process
type: Class
subclass of: regulation of macromolecule biosynthetic process
subclass of: regulation of cellular biosynthetic process
subclass of: regulation of RNA metabolic process
creation date: 2011-10-17T11:36:25Z
definition: Any process that modulates the frequency, rate or extent of RNA biosynthetic process.
id: GO:2001141
has_obo_namespace: biological_process
created by: dph
has_exact_synonym: regulation of RNA anabolism
has_exact_synonym: regulation of RNA biosynthesis
has_exact_synonym: regulation of RNA formation
has_exact_synonym: regulation of RNA synthesis
imported from: go.owl

negative regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity
type: Class
subclass of: regulation of oxidoreductase activity
subclass of: negative regulation of oxidoreductase activity
creation date: 2011-11-16T11:34:17Z
definition: Any process that stops, prevents or reduces the frequency, rate or extent of hydroxymethylglutaryl-CoA reductase (NADPH) activity.
id: GO:2001216
has_obo_namespace: biological_process
has_related_synonym: negative regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity
has_related_synonym: negative regulation of HMG-CoA reductase activity
created by: rfoulger
imported from: go.owl

data item
type: Class
subclass of: information content entity
imported from: dron.owl

information content entity
type: Class
subclass of: generically dependent continuant
imported from: dron.owl
imported from: iao.owl
imported from: oae.owl

curation status specification
type: Class
equivalent class: Class
  one of: ready for release
  one of: metadata incomplete
  one of: example to be eventually removed
  one of: uncurated
  one of: pending final vetting
  one of: metadata complete
  one of: organizational term
  one of: requires discussion
  one of: to be replaced with external ontology term
subclass of: data about an ontology part
editor note: Better to represent curation as a process with parts and then relate labels to that process (in IAO meeting)
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
definition source: OBI_0000266
term editor: PERSON:Bill Bug
definition: The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value.
editor preferred term: curation status specification
has curation status: pending final vetting
imported from: dron.owl

data about an ontology part
type: Class
subclass of: data item
term editor: Person:Alan Ruttenberg
definition: data about an ontology part is a data item about a part of an ontology, for example a term
imported from: dron.owl

Eukaryota
type: Class
subclass of: organism
subclass of: Restriction
  on property: in taxon
  some values from: Eukaryota
imported from: oae.owl
imported from: uberon.owl

Opisthokonta
type: Class
subclass of: Eukaryota
subclass of: Restriction
  on property: in taxon
  some values from: Opisthokonta
imported from: oae.owl
imported from: uberon.owl

Metazoa
type: Class
subclass of: Opisthokonta
subclass of: Restriction
  on property: in taxon
  some values from: Metazoa
imported from: oae.owl
imported from: uberon.owl

Bilateria
type: Class
subclass of: Eumetazoa
subclass of: Restriction
  on property: in taxon
  some values from: Bilateria
imported from: oae.owl
imported from: uberon.owl

Eumetazoa
type: Class
subclass of: Metazoa
subclass of: Restriction
  on property: in taxon
  some values from: Eumetazoa
imported from: oae.owl
imported from: uberon.owl

adverse event
type: Class
subclass of: pathological bodily process
subclass of: Restriction
  on property: preceded_by
  some values from: medical intervention
editor note: Melanie Courtot and YH: More work is needed on how to restrict the scope of a term to be an 'adverse event', notably regarding temporal association. When is an appropirate time interval between a medical intervention and an adverse event observed? One week, one month, one year, or a lifetime? For some well-studied medical interventions (e.g., administration of many vaccines or drugs), we probably have a general idea. For many new interventions, we don't know much. In OAE, this issue is associated with defining the 'adverse event incubation time'.
alternative term: AE
editor note: YH: There has been discussion regarding whether the term 'side effect' is an alternative term for 'adverse event'. In AERO, the term 'AERO:adverse event' represents a subset of those adverse events for which causality has been established. In OAE, an adverse event for which causality has been established is called 'causal adverse event'.
definition: a pathological bodily process that occurs after a medical intervention. An adverse event is likely caused by the medical intervention; however, such a causal association is not required to be an adverse event.
editor note: YH: The main scope of OAE includes: (1) represent terms and relations in the area of adverse events, (2) assess possible associations between an adverse event and a medical intervention, particularly, identify any causal effect of a medical intervention to an adverse event; and (2) understand the mechanism (including molecular mechanisms) of causal adverse events.
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/25093068
comment: The OAE official website is: http://www.oae-ontology.org/.
definition source: WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
alternative term: adverse reaction
editor note: YH: An adverse event is a process that has specified output of some adverse medical outcome (e.g., symptom, sign or accident) after a medical intervention (or process) (e.g., administration of drug or vaccine). The medical intervention can be an administration of a drug, a vaccine (i.e., vaccination), or a special nutritional product (for example, dietary supplement, infant formula, medical food), surgery, or usage of a medical device.
definition source: WEB: http://en.wikipedia.org/wiki/Adverse_event
editor note: YH: An adverse event is possibly induced by the medical intervention. It can be caused by the medical intervention, or may not be caused by the medical intervention. One ultimate goal (or the goal in clinics) of study adverse events is to assess if the adverse event outcome is due to the medical intervention.
term editor: Yongqun He
imported from: oae.owl

medical intervention
type: Class
subclass of: planned process
definition: medical intervention is a planned process that has the goal of diagnosing, preventing or relieving illness or injury.
term editor: YH
definition source: WEB: http://wiki.answers.com/Q/What_is_medical_intervention
imported from: oae.owl

drug administration
type: Class
subclass of: medical intervention
definition: a medical intervention where a patient is administered with a drug
term editor: YH
imported from: oae.owl

sensory neuropathy AE
type: Class
subclass of: neuropathy AE
definition: a peripheral neuropathy AE which has an outcome of sensory neuropathy that involves damage to nerves of the peripheral nervous system.
alternative term: sensory neuropathy AE
term editor: YH, AG
imported from: oae.owl

motor neuropathy AE
type: Class
subclass of: neuropathy AE
definition: a peripheral neuropathy AE which is caused by a damage to motor neurons
term editor: AG, YH
imported from: oae.owl

polyneuropathy AE
type: Class
subclass of: neuropathy AE
definition source: WEB: http://www.merckmanuals.com/home/brain_spinal_cord_and_nerve_disorders/peripheral_nerve_disorders/polyneuropathy.html
term editor: AG, YH, RR
see also: SIDER: C0152025
definition: A peripheral neuropathy AE which is characterized by damage to more than one nerve
see also: HPO: HP_0001271
see also: MedDRA ID: 10036105
imported from: oae.owl

peripheral neuropathy AE
type: Class
equivalent class: Restriction
  on property: adverse event occurs in
  some values from: peripheral nervous system
subclass of: neuropathy AE
see also: MedDRA: 10029331
definition: an neuropathy AE that results in a damage to the peripheral nervous system (PNS, outside the brain and spinal cord), the vast communication network that transmits information from the brain and the spinal cord (the central nervous system) to every other part of the body.
alternative term: neuropathy peripheral AE
definition source: WEB: http://www.ninds.nih.gov/disorders/peripheralneuropathy/detail_peripheralneuropathy.htm
term editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Peripheral_neuropathy
imported from: oae.owl

paresthesia AE
type: Class
subclass of: sensory neuropathy AE
term editor: YH
definition: a sensory neuropathy AE that shows a sensation of tingling, pricking, or numbness of a person's skin with no apparent long-term physical effect.
definition source: WEB: http://en.wikipedia.org/wiki/Paraesthesia
see also: MedDRA: 10033775
comment: Paresthesia is more generally known as the feeling of "pins and needles" or of a limb being "asleep" (although this is not directly related to the phenomenon of sleep). The manifestation of paresthesia may be transient or chronic.
imported from: oae.owl

neuropathy AE
type: Class
subclass of: nervous system AE
definition source: WEB: http://www.neuropathy.org/
see also: SIDER: C0442874
definition: a nervous system AE that shows a damage to or disease affecting the nerves.
definition source: WEB: http://www.emedicinehealth.com/neuropathy/article_em.htm
definition source: WEB: http://www.medicalnewstoday.com/articles/147963.php
see also: HPO: HP_0007141
term editor: YH, RR
imported from: oae.owl

nervous system AE
type: Class
subclass of: adverse event
definition: an AE that occurs in nervous system.
see also: MP: MP_0003633
term editor: YH
imported from: oae.owl

neuritis AE
type: Class
subclass of: neuropathy AE
see also: MP: MP_0006082
see also: MedDRA ID: 10029240
definition: a peripheral neuropathy AE which has an outcome of neuritis, the local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord
imported from: oae.owl

neurotoxicity AE
type: Class
subclass of: nervous system AE
definition source: WEB: http://en.wikipedia.org/wiki/Neurotoxicity
definition: a nervous system AE that alters the normal activity of the nervous system due to exposure to neurotoxins, causes damage to nervous tissue
term editor: SZ, SS, YH
see also: MedDRA: 10029350
imported from: oae.owl

peripheral sensorimotor neuropathy AE
type: Class
subclass of: peripheral sensory neuropathy AE
see also: MedDRA: 10056673
comment: Neuropathy can affect nerves that provide feeling (sensory neuropathy) or cause movement (motor neuropathy). It can also affect both, in which case it is called a sensorimotor neuropathy.
term editor: SZ, SS, YH
definition: a peripheral sensory neuropathy AE that results in the patient losing the ability to move or feel.
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000750.htm
imported from: oae.owl

peripheral sensory neuropathy AE
type: Class
subclass of: sensory neuropathy AE
subclass of: Restriction
  on property: adverse event occurs in
  some values from: peripheral nervous system
see also: MedDRA: 10034620
term editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/Peripheral+sensory+neuropathy
see also: SIDER: C0151313
definition: a sensory neuropathy AE that has an outcome of damaged nerves outside the brain and spinal cord
see also: HPO: HP_0000763
imported from: oae.owl

carpal tunnel syndrome AE
type: Class
subclass of: peripheral neuropathy AE
definition: Carpal tunnel syndrome AE is a peripheral neuropathy AE that is a median entrapment neuropathy that causes paresthesia, pain, numbness, and other symptoms in the distribution of the median nerve due to its compression at the wrist in the carpal tunnel.
definition source: WEB: http://en.wikipedia.org/wiki/Carpal_tunnel_syndrome
see also: MedDRA: 10007697
term editor: JX, LW, YH
definition source: WEB: http://emedicine.medscape.com/article/1141168-clinical#showall
Chinese translation: 腕管综合征
alternative term: median nerve neuropathy AE
imported from: oae.owl

ischemic optic neuropathy AE
type: Class
subclass of: optic neuropathy AE
alternative term: optic ischemic neuropathy AE
definition source: WEB: http://www.merckmanuals.com/professional/eye_disorders/optic_nerve_disorders/ischemic_optic_neuropathy.html
definition source: WEB: http://www.geteyesmart.org/eyesmart/diseases/ischemic-optic-neuropathy/
term editor: RR
definition: an optic neuropahty AE which shows an infarction of the optic disk which presents as painless vision loss
see also: MedDRA: 10030924
imported from: oae.owl

optic neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: Restriction
  on property: occurs in
  some values from: eye
definition: a peripheral neuropathy AE which shows an damage or abnormality to the nerves in the eyes.
term editor: RR, YH
see also: MedDRA: 10061323
definition source: WEB: http://www.allaboutvision.com/conditions/optic-neuritis.htm
imported from: oae.owl

neuroretinitis AE
type: Class
subclass of: optic neuropathy AE
see also: MedDRA: 10060701
definition: an optic neuropathy AE characterized by optic disc swelling, peripapillary and macular hard exudates, and vitreous cells.
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/6466175
term editor: RR, YH
imported from: oae.owl

anterior ischemic optic neuropathy AE
type: Class
subclass of: ischemic optic neuropathy AE
see also: MedDRA: 10068250
definition source: WEB: http://emedicine.medscape.com/article/1216891-overview
definition source: WEB: http://www.geteyesmart.org/eyesmart/diseases/ischemic-optic-neuropathy/
term editor: RR, YH
alternative term: AION
definition: an optic neuropathy AE characterized by vision loss, optic disc swelling, flame hemorrhages, and cotton-wool exudates. It occurs when blood flow is interrupted to the front (anterior) part of the optic nerve (also called optic nerve head).
imported from: oae.owl

non-arteritic anterior ischemic optic neuropathy AE
type: Class
subclass of: anterior ischemic optic neuropathy AE
see also: MedDRA: 10068249
definition source: WEB: http://emedicine.medscape.com/article/1216891-clinical#a0217
term editor: RR, YH
definition: a type of anterior ischemic optic neuropathy AE that presents primarily with vision loss, especially upon wakening, and sectorial disc edema.
imported from: oae.owl

mixed neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
definition source: WEB: http://www.aafp.org/afp/2010/0401/p887.html
term editor: RR, YH
definition: a peripheral neuropathy AE that shows a combination of axonal and demyelinating neuropathy.
imported from: oae.owl

sensory peripheral polyneuropathy AE
type: Class
subclass of: peripheral sensory neuropathy AE
definition source: WEB: http://www.merckmanuals.com/home/brain_spinal_cord_and_nerve_disorders/peripheral_nerve_disorders/polyneuropathy.html
term editor: RR, YH
definition: a peripheral sensory neuropathy AE that shows neuropathy in many sensory nerves at one time
imported from: oae.owl

peripheral demyelinating polyneuropathy AE
type: Class
subclass of: peripheral neuropathy AE
term editor: RR, YH
definition: a peripheral neuropathy AE that results from the loss of the myelin sheath on peripheral nerves roughly evenly distributed on both sides of the body
imported from: oae.owl

diabetic neuropathy AE
type: Class
subclass of: neuropathy AE
definition: a neuropathy AE that shows nerve damage and occurs in a patient with diabetes
definition source: WEB: http://www.mayoclinic.org/diseases-conditions/diabetic-neuropathy/basics/definition/con-20033336
term editor: RR, YH
see also: MedDRA: 10012680
imported from: oae.owl

neurological deficit AE
type: Class
subclass of: nervous system AE
term editor: RR, YH
definition: a nervous system AE that is an umbrella term referring to conditions relating to the nervous system, including loss of sensation and paralysis
definition source: WEB: http://en.wikipedia.org/wiki/Functional_neurological_deficit
imported from: oae.owl

planned process
type: Class
subclass of: process
definition: A processual entity that realizes a plan which is the concretization of a plan specification.
imported from: oae.owl
imported from: obi.owl
imported from: vo.owl

processed material
type: Class
subclass of: material entity
imported from: http://purl.obolibrary.org/obo/obi.owl
example of usage: Examples include gel matrices, filter paper, parafilm and buffer solutions, mass spectrometer, tissue samples
definition: Is a material entity that is created or changed during material processing.
term editor: PERSON: Alan Ruttenberg
editor preferred term: processed material
has curation status: ready for release
imported from: dron.owl

scattered molecular aggregate
type: Class
subclass of: material entity
editor preferred term: scattered molecular aggregate
example of usage: the sodium and chloride ions in a glass of salt water
definition: A scattered molecular aggregate is a material entity that consists of all the molecules of a specific type that are located in some bounded region and which is part of a more massive material entity that has parts that are other such aggregates
alternative term: Collective
definition source: Discussion in Karslruhe with, among others, Alan Rector, Stefan Schulz, Marijke Keet, Melanie Courtot, and Alan Ruttenberg. With inspiration from the paper Granularity, scale and collectivity: When size does and does not matter, Alan Recto, Jeremy Rogers, Thomas Bittner, Journal of Biomedical Informatics 39 (2006) 333-349
term editor: PERSON: Alan Ruttenberg
definition: a material entity that consists of all the molecules of a specific type that are located in some bounded region and which is part of a more massive material entity that has parts that are other such aggregates
has curation status: metadata incomplete
imported from: dron.owl
imported from: obi.owl

organism
type: Class
subclass of: material entity
subclass of: Restriction
  on property: has quality at some time
  some values from: age
editor note: 10/21/09: This is a placeholder term, that should ideally be imported from the NCBI taxonomy, but the high level hierarchy there does not suit our needs (includes plasmids and 'other organisms')
term editor: GROUP: OBI Biomaterial Branch
definition: A material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs.
definition source: WEB: http://en.wikipedia.org/wiki/Organism
example of usage: animal
example of usage: fungus
editor preferred term: organism
example of usage: plant
example of usage: virus
has curation status: ready for release
imported from: oae.owl
imported from: obi.owl

drug-associated neuropathy AE
type: Class
subclass of: adverse event
term editor: YH, RR
definition: a neuropathy adverse event that is associated with a drug.

role in cellular and molecular interactions
type: Class
subclass of: role
term editor: RR, YH

drug-associated mixed neuropathy AE
type: Class
subclass of: mixed neuropathy AE
term editor: RR, YH

drug-associated peripheral neuropathy adverse event
type: Class
subclass of: peripheral neuropathy AE
term editor: RR, YH

drug-associated motor neuropathy AE
type: Class
subclass of: motor neuropathy AE
term editor: RR, YH

drug-associated neuritis neuropathy AE
type: Class
subclass of: neuritis AE
term editor: RR, YH

drug-associated optic neuropathy AE
type: Class
subclass of: optic neuropathy AE
term editor: RR, YH

drug-associated diabetic neuropathy AE
type: Class
subclass of: diabetic neuropathy AE
term editor: RR, YH

drug-associated neuroretinitis neuropathy AE
type: Class
subclass of: neuroretinitis AE
term editor: RR, YH

drug-associated polyneuropathy AE
type: Class
subclass of: polyneuropathy AE
term editor: RR, YH

drug-associated sensory neuropathy AE
type: Class
subclass of: sensory neuropathy AE
term editor: RR, YH

drug-associated neurotoxicity neuropathy AE
type: Class
subclass of: neurotoxicity AE
term editor: RR, YH

drug-associated peripheral sensory neuropathy AE
type: Class
subclass of: peripheral sensory neuropathy AE
term editor: RR, YH

drug-associated sensory peripheral polyneuropathy AE
type: Class
subclass of: sensory peripheral polyneuropathy AE
term editor: RR, YH

drug-associated peripheral sensorimotor neuropathy AE
type: Class
subclass of: peripheral sensorimotor neuropathy AE
term editor: RR, YH

drug-associated peripheral demyelinating polyneuropathy AE
type: Class
subclass of: peripheral demyelinating polyneuropathy AE
term editor: RR, YH

drug-associated anterior ischemic optic neuropathy AE
type: Class
subclass of: anterior ischemic optic neuropathy AE
term editor: RR, YH

drug-associated non-arteritic anterior ischemic optic neuropathy AE
type: Class
subclass of: non-arteritic anterior ischemic optic neuropathy AE
term editor: RR, YH

drug-associated carpal tunnel syndrome AE
type: Class
subclass of: carpal tunnel syndrome AE
term editor: RR, YH

drug-associated neurological deficit AE
type: Class
subclass of: neurological deficit AE
term editor: RR, YH

drug-associated paresthesia AE
type: Class
subclass of: paresthesia AE
term editor: RR, YH

ciprofloxacin hydrochloride (Ciloxan, Cipro, Cetraxal)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Ciprofloxacin Oral Tablet
definition source: WEB: http://www.fda.gov/downloads/Drugs/EmergencyPreparedness/BioterrorismandDrugPreparedness/UCM130802.pdf
term editor: RR, AG, YH

cefepime (Maxipime)-associated neurotoxicity AE
type: Class
subclass of: neurotoxicity AE
subclass of: drug-associated neurotoxicity neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: cefepime Injectable Solution
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/050679s036lbl.pdf

penicillin G benzathine (Bicillin L-A)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: penicillin G benzathine 115 MG/ML Oral Solution
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/050141s231lbl.pdf

fosaprepitant dimeglumine (Emend)-associated sensory neuropathy AE
type: Class
subclass of: sensory neuropathy AE
subclass of: drug-associated sensory neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Fosaprepitant dimeglumine
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021549s021lbl.pdf

emtricitabine (Emtriva)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: emtricitabine Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021500s019lbl.pdf
term editor: RR, AG, YH

emtricitabine (Emtriva)-associated peripheral neuritis AE
type: Class
subclass of: neuritis AE
subclass of: drug-associated neuritis neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: emtricitabine Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021500s019lbl.pdf
term editor: RR, AG, YH

ropivacaine (Naropin)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: ropivacaine Injectable Solution
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020533s028lbl.pdf

omeprazole (Prilosec)-associated anterior ischemic optic neuropathy AE
type: Class
subclass of: anterior ischemic optic neuropathy AE
subclass of: drug-associated anterior ischemic optic neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Omeprazole Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/019810s095,022056s011lbl.pdf
term editor: RR, AG, YH

hydroxyurea (Droxia, Hydrea)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: hydroxyurea Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/016295s041s042lbl.pdf

vemurafenib (Zelboraf)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Vemurafenib Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/202429s000lbl.pdf

ipilimumab (Yervoy)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: ipilimumab
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/125377s0000lbl.pdf
term editor: RR, AG, YH

golimumab (Simponi)-associated peripheral demylinating polyneuropathy AE
type: Class
subclass of: peripheral demyelinating polyneuropathy AE
subclass of: drug-associated peripheral demyelinating polyneuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: golimumab
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/125289s0038lbl.pdf
term editor: RR, AG, YH

peginterferon alfa-2b (Peg Intron, Sylatron)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: peginterferon alfa-2b Injectable Solution
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/103949s5217s5222lbl.pdf

infliximab (Remicade)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: infliximab
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/103772s5301lbl.pdf

tacrolimus (Astagraf XL, Hecoria, Prograf, Protopic)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Tacrolimus Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/050708s036s037,050709s028s030lbl.pdf
term editor: RR, AG, YH

tacrolimus (Astagraf XL, Hecoria, Prograf, Protopic)-associated neurotoxicity AE
type: Class
subclass of: neurotoxicity AE
subclass of: drug-associated neurotoxicity neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Tacrolimus Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/050708s036s037,050709s028s030lbl.pdf

tesamorelin (Egrifta)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: tesamorelin Injectable Solution
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/022505s001s003lbl.pdf
term editor: RR, AG, YH

docetaxel (Taxotere, Docefrez)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: docetaxel Injectable Solution
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/022234s000lbl.pdf
term editor: RR, AG, YH

etravirine (Intelence)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: etravirine
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/022187s008lbl.pdf

maraviroc (Selzentry)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: maraviroc
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/022128s007lbl.pdf

bupropion (Aplezin, Wellbutrin, Zyban, Budeprion SR, Buproban, Forfivo XL)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Bupropion Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/022108s005s006lbl.pdf
term editor: RR, AG, YH

nilotinib (Tasigna)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: nilotinib Oral Capsule
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/022068s008s009lbl.pdf

ixabepilone (Ixempra)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: ixabepilone
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/022065s006lbl.pdf
term editor: RR, AG, YH

telbivudine (Tyzeka)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: telbivudine Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/022011S012,022154S009lbl.pdf

dasatinib (Sprycel)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: dasatinib
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021986s009s010lbl.pdf

sorafenib (NexAVAR)-associated sensory neuropathy AE
type: Class
subclass of: sensory neuropathy AE
subclass of: drug-associated sensory neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: sorafenib Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021923s012lbl.pdf

lenalidomide (Revlimid)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: lenalidomide
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021880s023lbl.pdf

tipranavir (Aptivus)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: tipranavir Oral Capsule
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021814s011lbl.pdf

metronidazole (Flagyl, Metrocream, Metrogel, Metrolotion, Noritate)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Metronidazole Oral Suspension
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021806s003lbl.pdf
term editor: RR, AG, YH

histrelin (Vantas, Supprelin LA)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: histrelin Injectable Solution
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021732s007s010s012lbl.pdf

bortezomib (Velcade)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: bortezomib Injectable Solution
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021602s029s030lbl.pdf

imatinib (Gleevec)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: imatinib Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021588s030s031lbl.pdf
term editor: RR, AG, YH

daptomycin (Cubicin)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Daptomycin
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021572s038lbl.pdf

atazanavir (Reyataz)-associated peripheral neurologic symptoms AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Atazanavir
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021567s026lbl.pdf

enfuvirtide (Fuzeon)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: enfuvirtide
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021481s020lbl.pdf

pemetrexed (Alimta)-associated motor neuropathy AE
type: Class
subclass of: motor neuropathy AE
subclass of: drug-associated motor neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: pemetrexed Injectable Solution
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021462s029s030s032lbl.pdf
term editor: RR, AG, YH

pemetrexed (Alimta)-associated sensory neuropathy AE
type: Class
subclass of: sensory neuropathy AE
subclass of: drug-associated sensory neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: pemetrexed Injectable Solution
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021462s029s030s032lbl.pdf
term editor: RR, AG, YH

vardenafil (Levitra, Staxyn)-associated non-arteritic anterior ischemic optic neuropathy AE
type: Class
subclass of: non-arteritic anterior ischemic optic neuropathy AE
subclass of: drug-associated non-arteritic anterior ischemic optic neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: vardenafil Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021400s013lbl.pdf
term editor: RR, AG, YH

tenofovir (Viread)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: tenofovir disoproxil Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021356s041lbl.pdf

voriconazole (Vfend)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: voriconazole Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021266s035,021267s040,021630s026lbl.pdf
term editor: RR, AG, YH

gemifloxacin (Factive)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: gemifloxacin
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021158s021lbl.pdf

moxifloxacin (Avelox, Vigamox, Moxeza)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: moxifloxacin Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021085s050s053,021277s046s050lbl.pdf

bexarotene (Targretin)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: bexarotene Topical Gel
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021055s006lbl.pdf
term editor: RR, AG, YH

cytarabine (Cytosar-U, Tarabine PFS)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Cytarabine liposome
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021041s023lbl.pdf

eletriptan (Relpax)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: eletriptan
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021016s018lbl.pdf
term editor: RR, AG, YH

efavirenz (Sustiva)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: efavirenz Oral Capsule
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020972s040lbl.pdf
term editor: RR, AG, YH

leflunomide (Arava)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: leflunomide Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020905s022lbl.pdf
term editor: RR, AG, YH

capecitabine (Xeloda)-associated peripheral sensory neuropathy AE
type: Class
subclass of: sensory neuropathy AE
subclass of: drug-associated peripheral sensory neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: capecitabine Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020896s026lbl.pdf

sildenafil (Revatio, Viagra)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: sildenafil Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020895s036lbl.pdf
term editor: RR, AG, YH

montelukast (Singulair)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: montelukast Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020829s060,020830s062,021409s037lbl.pdf

exemestane (Aromasin)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: exemestane Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020753s009s011s012lbl.pdf
term editor: RR, AG, YH

triptorelin (Trelstar)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Triptorelin Injectable Suspension
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020715s025,021288s022,022437s003lbl.pdf

pramipexole (Mirapex)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Pramipexole Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020667s025lbl.pdf

ritonavir (Norvir)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Ritonavir Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020659s055,022417s006lbl.pdf
term editor: RR, AG, YH

nevirapine (Viramune)-associated paresthesia AE
type: Class
subclass of: paresthesia AE
subclass of: drug-associated paresthesia AE
subclass of: Restriction
  on property: has participant
  some values from: Nevirapine Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020636s039_020933s030lbl.pdf

levofloxacin (Levaquin, Quixin, Iquix)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Levofloxacin Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020634s062s064,020635s068s070,021721s029s031lbl.pdf
term editor: RR, AG, YH

lamivudine (Epivir)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Lamivudine Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020564s031,020596s030lbl.pdf

zafirlukast (Accolate)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: zafirlukast Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020547s031lbl.pdf
term editor: RR, AG, YH

gemcitabine (Gemzar)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: gemcitabine Injectable Solution
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020509s069lbl.pdf

topiramate (Topamax, Topiragen, Trokendi XR, Qudexy XR)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: topiramate Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020505s042,020844s036lbl.pdf
term editor: RR, AG, YH

vigabatrin (Sabril)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Vigabatrin Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020427s002lbl.pdf
term editor: RR, AG, YH

stavudine (Zerit)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Stavudine Oral Capsule
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020412s038,020413s030lbl.pdf
term editor: RR, AG, YH

losartan (Cozaar)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Losartan Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020386s056lbl.pdf

fluvastatin (Lescol)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: fluvastatin Oral Capsule
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020261s042,021192s016lbl.pdf

desipramine (Norpramin)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Desipramine Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020156s048lbl.pdf

levoleucovorin (Fusilev)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: levoleucovorin
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020140s002lbl.pdf

diltiazem (Dilacor, Cardizem, Cartia XT, Tiazac, Dilt-CD, Dilt-XR, Diltia XT)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Diltiazem Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020092s017lbl.pdf
term editor: RR, AG, YH

paroxetine (Paxil, Pexeva, Brisdelle)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Paroxetine Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020031s058s066,020710s022s030lbl.pdf

leuprolide acetate (Lupron, Eligard, Viadur)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Leuprolide Acetate 5 MG/ML Injectable Solution
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019943s032,020011s039lbl.pdf
term editor: RR, AG, YH

ramipril (Altace)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Ramipril Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019901s058lbl.pdf

pravastatin (Pravachol)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Pravastatin Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019898s061lbl.pdf
term editor: RR, AG, YH

sotalol (Betapace, Sorine, Sotylize)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Sotalol Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019865s020lbl.pdf

acitretin (Soriatane)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Acitretin Oral Capsule
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019821s018lbl.pdf
term editor: RR, AG, YH

amlodipine (Norvasc)-associated neuropathy peripheral AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Amlodipine Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019787s052lbl.pdf

simvastatin (Zocor)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Simvastatin Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019766s083lbl.pdf

ifosfamide (Ifex)-associated polyneuropathy AE
type: Class
subclass of: polyneuropathy AE
subclass of: drug-associated polyneuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Ifosfamide Injectable Solution
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019763s016lbl.pdf

ofloxacin (Floxin, Ocuflox)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Ofloxacin Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019735s061lbl.pdf

zidovudine (Retrovir)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Zidovudine Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019655s052,019910s039,020518s022lbl.pdf

lisinopril (Prinivil, Zestril)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Lisinopril Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019558s054lbl.pdf
term editor: RR, AG, YH

ciprofloxacin (Cipro, Ciloxan, Cetraxal)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Ciprofloxacin Oral Capsule
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019537s074,020780s032lbl.pdf
term editor: RR, AG, YH

betaxolol (Kerlone, Betoptic S)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Betaxolol Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019507s008lbl.pdf
term editor: RR, AG, YH

norfloxacin (Noroxin)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Norfloxacin Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019384s060lbl.pdf
term editor: RR, AG, YH

amiodarone (Cordarone, Pacerone)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Amiodarone Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/018972s044lbl.pdf
term editor: RR, AG, YH

cisplatin (Platinol)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Cisplatin Injectable Solution
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/018057s081lbl.pdf
term editor: RR, AG, YH

carmustine (Bicnu, Gliadel)-associated neuroretinitis AE
type: Class
subclass of: neuroretinitis AE
subclass of: drug-associated neuroretinitis neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Carmustine Injectable Solution
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/017422s042lbl.pdf

deferoxamine (Desferal)-associated mixed neuropathy AE
type: Class
subclass of: mixed neuropathy AE
subclass of: drug-associated mixed neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Deferoxamine Injectable Solution
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/016267s050lbl.pdf

chlorambucil (Leukeran)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Chlorambucil
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/010669s032lbl.pdf

propylthiouracil-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Propylthiouracil Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/006188s021s022lbl.pdf

eribulin (Halaven)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: eribulin
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/201532lbl.pdf

cabazitaxel (Jevtana)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: cabazitaxel
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/201023lbl.pdf
term editor: RR, AG, YH

certolizumab pegol (Cimzia)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: certolizumab pegol Prefilled Syringe
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/125160s111lbl.pdf
term editor: RR, AG, YH

erlotinib (Tarceva)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: erlotinib
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021743s14s16lbl.pdf
term editor: RR, AG, YH

aprepitant (Emend)-associated sensory neuropathy AE
type: Class
subclass of: sensory neuropathy AE
subclass of: drug-associated sensory neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: aprepitant
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021549s017lbl.pdf
term editor: RR, AG, YH

miglustat (Zavesca)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Miglustat Oral Capsule
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021348s008lbl.pdf
term editor: RR, AG, YH

valganciclovir (Valcyte)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: valganciclovir Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021304s008,022257s003lbl.pdf

linezolid (Zyvox)-associated optic neuropathy AE
type: Class
subclass of: optic neuropathy AE
subclass of: drug-associated optic neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: linezolid Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021130s022lbl.pdf
term editor: RR, AG, YH

ziprasidone (Geodon)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: ziprasidone Oral Capsule
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020825s038,020919s025,021483s005lbl.pdf
term editor: RR, AG, YH

topotecan (Hycamtin)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Topotecan Oral Capsule
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020671s016s017lbl.pdf
term editor: RR, AG, YH

bicalutamide (Casodex)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: bicalutamide Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020498s022lbl.pdf

venlafaxine (Effexor)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: venlafaxine Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020151s056s057lbl.pdf

itraconazole (Onmel, Sporanox)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Itraconazole Oral Capsule
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020083s046lbl.pdf

fludarabine (Fludara)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: fludarabine Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020038s033lbl.pdf
term editor: RR, AG, YH

zolpidem (Zolpimist, Ambien, Edluar, Intermezzo)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: zolpidem Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/019908s029lbl.pdf

triamcinolone (Aristocort, Azmacort, Cinolar, Kenalog, Nasacort, Clinacort, Triam-Forte, Triamcot, Aristospan)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Triamcinolone Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/012802s031lbl.pdf
term editor: RR, AG, YH

metronidazole (Flagyl, Metrocream, Metrogel, Metrolotion, Noritate)-associated optic neuropathy AE
type: Class
subclass of: optic neuropathy AE
subclass of: drug-associated optic neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Metronidazole Oral Suspension
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/012623s061lbl.pdf

oxaliplatin (Eloxatin)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: oxaliplatin Injectable Solution
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/078810s000lbl.pdf

cyclosporine (Gengraf, Neoral, Sandimmune, Restasis)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Cyclosporine Oral Capsule
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/050715s028,050716s029lbl.pdf
term editor: RR, AG, YH

capsaicin (Zostrix, Capsagel, Capsagesic HP, Capsin, Trixaicin, Pain Enz, Rid-A-Pain, Sportsmed)-associated peripheral sensory neuropathy AE
type: Class
subclass of: sensory neuropathy AE
subclass of: drug-associated peripheral sensory neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Capsaicin Topical Solution
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/022395lbl.pdf

nelarabine (Arranon)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: nelarabine Injectable Solution
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/021877s001lbl.pdf
term editor: RR, AG, YH

dapsone (Aczone)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Dapsone Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/021794s006lbl.pdf

rasagiline (Azilect)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: rasagiline Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/021641s002s003s004s005s007s008s010lbl.pdf
term editor: RR, AG, YH

eszopiclone (Lunesta)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Eszopiclone
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/021476s012lbl.pdf
term editor: RR, AG, YH

almotriptan (Axert)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: almotriptan
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/021001s010s011lbl.pdf
term editor: RR, AG, YH

atorvastatin (Lipitor)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: atorvastatin Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020702s056lbl.pdf
term editor: RR, AG, YH

tolcapone (Tasmar)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: tolcapone Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020697s013s015lbl.pdf
term editor: RR, AG, YH

nitrofurantoin (Furadantin)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Nitrofurantoin Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020064s019lbl.pdf

olsalazine sodium (Dipentum)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: olsalazine Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/019715s027lbl.pdf

mefloquine (Lariam)-associated sensory neuropathy AE
type: Class
subclass of: sensory neuropathy AE
subclass of: drug-associated sensory neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Mefloquine Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/019591s026s028lbl.pdf
term editor: RR, AG, YH

mefloquine (Lariam)-associated motor neuropathy AE
type: Class
subclass of: motor neuropathy AE
subclass of: drug-associated motor neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Mefloquine Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/019591s026s028lbl.pdf

misoprostol (Cytotec)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Misoprostol Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/019268s041lbl.pdf
term editor: RR, AG, YH

indomethacin (Indocin, Tivorbex)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Indomethacin Oral Suspension
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/018332s032lbl.pdf

etidronate (Didronel)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Etidronate Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/017831s055lbl.pdf
term editor: RR, AG, YH

sulfasalazine (Azulfidine, Sulfazine)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Sulfasalazine Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/007073s124lbl.pdf
term editor: RR, AG, YH

doxorubicin (Doxil, Adriamycin)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: doxorubicin liposome
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050718s033lbl.pdf

mesalamine (Canasa, Pentasa, Rowasa, Lialda, Apriso, Asacol HD, sfRowasa, Delzicol)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: mesalamine Extended Release Capsule
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2008/022301lbl.pdf
term editor: RR, AG, YH

selegiline (Emsam, Eldepryl, Zelapar)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Selegiline Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021479s003s004lbl.pdf

ropinirole (Requip)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: ropinirole Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2008/020658s018s020s021lbl.pdf

enalapril maleate (Vasotec, Epaned)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Enalapril Maleate 2.5 MG Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2008/018998s071lbl.pdf

cyclobenzaprine (Flexeril, Amrix, Fexmid, FusePaq Tabradol)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: cyclobenzaprine Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2007/021777lbl.pdf

tinidazole (Tindamax)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Tinidazole Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2007/021618s003lbl.pdf
term editor: RR, AG, YH

zaleplon (Sonata)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: zaleplon Oral Capsule
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2007/020859s011lbl.pdf

foscarnet (Foscavir)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Foscarnet Injectable Solution
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2007/020068s017lbl.pdf

succimer (Chemet)-associated sensorimotor neuropathy AE
type: Class
subclass of: peripheral sensorimotor neuropathy AE
subclass of: drug-associated peripheral sensorimotor neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Succimer Oral Capsule
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2007/019998s013lbl.pdf

clomipramine (Anafranil)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Clomipramine Oral Capsule
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2007/019906s34lbl.pdf

nortriptyline (Aventyl, Pamelor)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Nortriptyline Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2007/018013s58lbl.pdf
term editor: RR, AG, YH

trimipramine (Surmontil)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Trimipramine Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2007/016792s025lbl.pdf

thalidomide (Thalomid)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Thalidomide Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2006/021430s000,020785s031lbl.pdf

cevimeline (Evoxac)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: cevimeline
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2006/020989s008lbl.pdf
term editor: RR, AG, YH

tizanidine (Zanaflex)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: tizanidine Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2006/020397s021,021447s002lbl.pdf

didanosine (Videx)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Didanosine Chewable Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2006/020154s50,20155s39,20156s40,21183s16lbl.pdf
term editor: RR, AG, YH

ganciclovir (Cytovene, Vitrasert, Zirgan)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Ganciclovir Oral Capsule
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019661s030lbl.pdf

flucytosine (Ancobon)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Flucytosine Oral Capsule
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2006/017001s027lbl.pdf
term editor: RR, AG, YH

lomefloxacin (Maxaquin)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: lomefloxacin Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2005/20013s015lbl.pdf
term editor: RR, AG, YH

saquinavir (Invirase)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Saquinavir Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021785s001,002,020828s019,020,020628s022,023lbl.pdf
term editor: RR, AG, YH

valdecoxib (Bextra)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: valdecoxib Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2004/21341lbl.pdf

lovastatin (Altoprev, Mevacor)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Lovastatin Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2004/21316s010lbl.pdf

fluticasone (Flonase, Cutivate, Flovent)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: fluticasone Nasal Suspension
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2004/20549slr016,20548slr020,20121slr030_flonase_lbl.pdf
term editor: RR, AG, YH

penicillamine (Cuprimine, Depen)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Penicillamine Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2004/19853s012,014lbl.pdf

dexamethasone (Decadron, DexPak, Maxidex, Dekpak 13 day Taperpak, Baycadron Elixer, Ozurdex)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Dexamethasone Ophthalmic Ointment
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2004/11664slr062_decadron_lbl.pdf
term editor: RR, AG, YH

rofecoxib-associated median nerve neuropathy AE
type: Class
subclass of: carpal tunnel syndrome AE
subclass of: drug-associated carpal tunnel syndrome AE
subclass of: Restriction
  on property: has participant
  some values from: rofecoxib Oral Tablet
term editor: RR, AG, YH
comment: This drug has been withdrawn from the US market.
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2004/021052s026_021042s019lbl.pdf

basiliximab (Simulect)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: basiliximab
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/basnov010203LB.htm
term editor: RR, AG, YH

pergolide (Permax)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Pergolide Oral Tablet
comment: This drug has been withdrawn from the US market.
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/19385slr030,031,035_permax_lbl.pdf
term editor: RR, AG, YH

vinorelbine (Navelbine)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: vinorelbine Injectable Solution
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2002/20388S014lbl.pdf
term editor: RR, AG, YH

zalcitabine-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Zalcitabine Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2002/20199s16lbl.pdf
term editor: RR, AG, YH
comment: This drug has been discontinued from the US market.

cerivastatin (Baycol)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Cerivastatin sodium
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2001/20740S19lbl.pdf
term editor: RR, AG, YH
comment: This drug has been withdrawn from the US market.

delavirdine (Rescriptor)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Delavirdine
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2001/20705S8lbl.pdf

amiodarone hydrochloride (Cordarone, Pacerone)-associated optic neuropathy AE
type: Class
subclass of: optic neuropathy AE
subclass of: drug-associated optic neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Amiodarone Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/anda/98/74-739_Amiodarone_prntlbl.pdf

paclitaxel (Taxol, Onxol, Nov-Onxol, Paclitaxel Novaplus)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Paclitaxel Injectable Solution
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/anda/2002/75184_Paclitaxel_Prntlbl.pdf
term editor: RR, AG, YH

tadalafil (Cialis, Adcirca)-associated non-arteritic anterior ischemic optic neuropathy AE
type: Class
subclass of: non-arteritic anterior ischemic optic neuropathy AE
subclass of: drug-associated non-arteritic anterior ischemic optic neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: tadalafil Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=ff61b237-be8e-461b-8114-78c52a8ad0ae#nlm34084-4

rivastigmine (Exelon)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: rivastigmine Oral Capsule
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=fead084a-a376-4d57-bdf0-aa7ed3655505#nlm34084-4
term editor: RR, AG, YH

mitoxantrone hydrochloride (Novantrone)-associated neurological deficit AE
type: Class
subclass of: neurological deficit AE
subclass of: drug-associated neurological deficit AE
subclass of: Restriction
  on property: has participant
  some values from: Mitoxantrone Injectable Solution
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=fcb8ef8a-f770-4416-8fc5-fa01d98c8eee#nlm34084-4

zonisamide (Zonegran)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: zonisamide Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f94b2ba4-024f-4068-8759-da6c8d31c546#nlm34084-4

sotalol hydrochloride (Betapace, Sorine, Sotylize)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Sotalol Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f16f9ae6-d29f-4b31-a240-c7ebb0d7d36a#nlm34084-4

propofol (Diprivan, Fresenious Propoven)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Propofol Injectable Suspension
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=e3105799-a4b6-f3f4-e6e2-b2b29bbdb538#nlm34084-4

pentamidine (Nebupent, Pentam)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Pentamidine Injectable Solution
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=e2ad9d3c-b6c3-4f70-87e0-722a8ff94ccb#nlm34084-4
term editor: RR, AG, YH

procarbazine 50 MG oral capsule [Matulane]-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Procarbazine 50 MG Oral Capsule [Matulane]
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=de1c8271-64d8-4ea5-85e8-871faa4d7632#nlm34084-4

penicillin V potassium (Veetids, Truxcillin VK)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Penicillin V Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=d6918541-6285-48ea-8255-23212f9a3ad7#nlm34084-4

Imipramine pamoate (Tofranil-PM)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Imipramine Oral Capsule
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=d1dde497-1889-4424-af18-da7ca6459cf3#nlm34084-4

methylprednisolone acetate (Depo-Medrol)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Methylprednisolone Injectable Suspension
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=ccb4d123-7b12-4aef-8ef0-f8d68c1a6547#nlm34084-4
term editor: RR, AG, YH

sulfamethizole-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Sulfamethizole Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=be27854a-a805-4300-9729-accd1b7f226f#nlm34084-4
comment: This drug has been discontinued from the US market.

zolmitriptan (Zomig)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: zolmitriptan Oral Tablet
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=bac91e37-91ce-4bbf-77bc-ef5f242589f8#nlm34084-4
term editor: RR, AG, YH

ethambutol (Myambutol)-associated peripheral neuritis AE
type: Class
subclass of: neuritis AE
subclass of: drug-associated neuritis neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Ethambutol Oral Tablet
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b2f95b0b-9de3-4c0b-a46e-a7eee6428b4b#nlm34084-4
term editor: RR, AG, YH

ethambutol hydrochloride (Myambutol)-associated optic neuropathy AE
type: Class
subclass of: optic neuropathy AE
subclass of: drug-associated optic neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Ethambutol Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b2f95b0b-9de3-4c0b-a46e-a7eee6428b4b#nlm34084-4

rituximab (Rituxan)-associated peripheral sensory neuropathy AE
type: Class
subclass of: sensory neuropathy AE
subclass of: drug-associated sensory neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: rituximab Injectable Solution
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b172773b-3905-4a1c-ad95-bab4b6126563#nlm34084-4
term editor: RR, AG, YH

amitriptyline hydrochloride (Elavil, Vanatrip)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Amitriptyline Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=acd53964-52dc-4534-b20f-14a7561b8a6c#nlm34084-4

gabapentin (Gabarone, Neurontin, Gralise, FusePaq Fanatrex)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: gabapentin Oral Tablet
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=aa2e353f-860b-4d10-9a62-aad1c533b8aa#nlm34084-4
term editor: RR, AG, YH

tolmetin (Tolectin)-associated optic neuropathy AE
type: Class
subclass of: optic neuropathy AE
subclass of: drug-associated optic neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Tolmetin Oral Tablet
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=a6c72634-4613-4d21-bc9a-09dad17eb137#nlm34084-4
term editor: RR, AG, YH

megestrol (Megace)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Megestrol Oral Suspension
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=65b28775-ee59-88cf-e4d8-372c6c79ad14#nlm34084-4

pregabalin (Lyrica)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: pregabalin Oral Capsule
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=60185c88-ecfd-46f9-adb9-b97c6b00a553#nlm34084-4

imipramine (Tofranil, Tofranil-PM)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Imipramine Oral Tablet
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=55311747-710c-43c4-821d-76323ff2520e#nlm34084-4
term editor: RR, AG, YH

methylprednisolone (Medrol, Methylpred-DP)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Methylprednisolone Topical Ointment
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=532f0c6c-cd76-44d1-27b7-581cee86bc34#nlm34084-4

fluvoxamine maleate (Luvox)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Fluvoxamine Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=4d80812c-dfc1-456c-9368-697267630c2c#nlm34084-4

mitoxantrone (Novantrone)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Mitoxantrone Injectable Solution
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=4d0f0f1a-31af-40fa-9c64-e90891fa6ce4#nlm34084-4
term editor: RR, AG, YH

pantoprazole (Protonix)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: pantoprazole Enteric Coated Tablet
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=4b4edc09-bbfd-471f-ac16-6118937a6e7e#nlm34084-4

phenytoin (Dilantin, Phenytek)-associated sensory peripheral polyneuropathy AE
type: Class
subclass of: sensory peripheral polyneuropathy AE
subclass of: drug-associated sensory peripheral polyneuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Phenytoin Oral Tablet
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=4a4c577d-9267-40eb-9ed9-09ceb6377026#nlm34084-4
term editor: RR, AG, YH

trastuzumab (Herceptin)-associated motor neuropathy AE
type: Class
subclass of: motor neuropathy AE
subclass of: drug-associated motor neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: trastuzumab Injectable Solution
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=492dbdb2-077e-4064-bff3-372d6af0a7a2#nlm34084-4

trastuzumab (Herceptin)-associated sensory neuropathy AE
type: Class
subclass of: sensory neuropathy AE
subclass of: drug-associated sensory neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: trastuzumab Injectable Solution
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=492dbdb2-077e-4064-bff3-372d6af0a7a2#nlm34084-4
term editor: RR, AG, YH

losartan potassium (Cozaar)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Losartan Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=3f60ac2e-031a-48fa-ab47-4e3aec49cb83#nlm34084-4

metolazone (Mykrox, Zaroxolyn)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Metolazone Oral Tablet
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=34868f95-78d0-4089-8cbd-bec1cb730eda#nlm34084-4
term editor: RR, AG, YH

haloperidol (Haldol)-associated neurotoxicity AE
type: Class
subclass of: neurotoxicity AE
subclass of: drug-associated neurotoxicity neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Haloperidol Oral Solution
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=27cfe684-7d11-4f37-9c8b-b2bdd6b5348e#nlm34084-4

lomefloxacin hydrochloride (Maxaquin)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: lomefloxacin Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=173018f5-fd76-4480-90f8-4b7efe328444#nlm34084-4

ticlopidine (Ticlid)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Ticlopidine Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=13d85420-75e2-46e7-93eb-dcd10675cd03#nlm34084-4

disulfiram (Antabuse)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Disulfiram Oral Tablet
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=12850de3-c97c-42c1-b8d3-55dc6fd05750#nlm34084-4
term editor: RR, AG, YH

nitrofurantoin macrocrystals (Macrodantin)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Nitrofurantoin Oral Capsule
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=013433a1-c27c-4712-a03b-0949b2969fbb#nlm34084-4
term editor: RR, AG, YH

nitrofurantoin, monohydrate (Macrobid)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Nitrofurantoin Oral Capsule
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=013433a1-c27c-4712-a03b-0949b2969fbb#nlm34084-4

fluconazole (Diflucan)-associated paresthesia AE
type: Class
subclass of: paresthesia AE
subclass of: drug-associated paresthesia AE
subclass of: Restriction
  on property: has participant
  some values from: Fluconazole Oral Capsule
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=f694c617-3383-416c-91b6-b94fda371204&type=display
term editor: RR, AG, YH

fludarabine phosphate-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: fludarabine Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=f1ffd18c-9f6b-4479-94b9-6890bc730ecc&type=display

fentanyl (Actiq, Duragesic, Subsys, Fentora, Abstral)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Fentanyl Injectable Solution
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=90b94524-f913-48b3-3771-7b2fcffd888a&type=display
term editor: RR, AG, YH

insulin, protamine zinc, human 40 UNT/ML injectable suspension [ProZinc]-associated diabetic neuropathy AE
type: Class
subclass of: diabetic neuropathy AE
subclass of: drug-associated diabetic neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Insulin, Protamine Zinc, Human 40 UNT/ML Injectable Suspension [ProZinc]
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=8dbc0e47-8df9-4484-903b-70fdd26f7998&type=display
term editor: RR, AG, YH

fluorouracil (Carac, Efudex, Fluoroplex, Adrucil)-associated neurotoxicity AE
type: Class
subclass of: neurotoxicity AE
subclass of: drug-associated neurotoxicity neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Fluorouracil Oral Capsule
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=8379f1db-4255-4285-abd3-8ecdcaf03372&type=display
term editor: RR, AG, YH

carboplatin (Paraplatin)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Carboplatin Injectable Solution
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=806736d3-215a-4df5-8187-97f2161e5a53&type=display

isoniazid (Nydrazid)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: isoniazid Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=77795c31-1cdf-4a20-b4a1-cd15f5b310f1&type=display

methotrexate (Rheumatrex, Trexall, Otrexup, Rasuvo)-associated neurotoxicity AE
type: Class
subclass of: neurotoxicity AE
subclass of: drug-associated neurotoxicity neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Methotrexate Injectable Solution
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=6cf2e15a-6286-41f7-aa7d-3968d735c864&type=display
term editor: RR, AG, YH

imipramine hydrochloride (Tofranil)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Imipramine Oral Tablet
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=2f7d5e7f-79aa-4f3a-b9a6-758d9f3ce74d&type=display
term editor: RR, AG, YH

tamoxifen (Nolvadex, Soltamox)-associated neurotoxicity AE
type: Class
subclass of: neurotoxicity AE
subclass of: drug-associated neurotoxicity neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Tamoxifen Oral Tablet
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=063fa789-4570-4715-c3bd-1bad0449fb26&type=display
term editor: RR, AG, YH

colchicine (Colcrys, Mitigare)-associated sensory motor neuropathy AE
type: Class
subclass of: peripheral sensorimotor neuropathy AE
subclass of: drug-associated peripheral sensorimotor neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Colchicine / Probenecid Oral Tablet
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ee1583ac-c308-4beb-b602-9ecac4977026#section-6
term editor: RR, AG, YH

crizotinib (Xalkori)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: crizotinib
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/202570s003lbl.pdf
term editor: RR, AG, YH

allopurinol (Zyloprim, Aloprim)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Allopurinol Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=73cd79c1-6bab-4d7b-ae8b-0176efbaf5b9#nlm34084-4

aldesleukin (Proleukin)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Aldesleukin Injectable Solution
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/103293s5130lbl.pdf
term editor: RR, AG, YH

altretamine (Hexalen)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Altretamine Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=8456a8db-a7f6-4bc0-86be-e9c8c374140b&type=display

amantadine (Symmetrel)-associated paresthesia AE
type: Class
subclass of: paresthesia AE
subclass of: drug-associated paresthesia AE
subclass of: Restriction
  on property: has participant
  some values from: Amantadine Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=fc78c074-3ca8-4e29-9c18-8fab97558fc2&type=display

anastrozole (Arimidex)-associated paresthesia AE
type: Class
subclass of: paresthesia AE
subclass of: drug-associated paresthesia AE
subclass of: Restriction
  on property: has participant
  some values from: anastrozole Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=03586c40-eb32-45c5-beb7-6762a6b78790&type=display

auranofin (Ridaura)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Auranofin Oral Tablet
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=05c34ddf-a0f7-4267-83f5-d02be3defc37&type=display
term editor: RR, AG, YH

avanafil (Stendra)-associated non-arteritic anterior ischemic optic neuropathy AE
type: Class
subclass of: non-arteritic anterior ischemic optic neuropathy AE
subclass of: drug-associated non-arteritic anterior ischemic optic neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: avanafil Oral Tablet
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/202276s001lbl.pdf

carfilzomib (Kyprolis)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: carfilzomib Injectable Solution
term editor: RR, AG, YH
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/202714lbl.pdf

cladribine (Leustatin)-associated peripheral sensory neuropathy AE
type: Class
subclass of: sensory neuropathy AE
subclass of: drug-associated peripheral sensory neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Cladribine Injectable Solution
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a2592a9b-bca6-4a5a-89c2-855a0634d5fe&type=display
term editor: RR, AG, YH

cladribine (Leustatin)-associated motor neuropathy AE
type: Class
subclass of: motor neuropathy AE
subclass of: drug-associated motor neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Cladribine Injectable Solution
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a2592a9b-bca6-4a5a-89c2-855a0634d5fe&type=display

cladribine (Leustatin)-associated polyneuropathy AE
type: Class
subclass of: polyneuropathy AE
subclass of: drug-associated polyneuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Cladribine Injectable Solution
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a2592a9b-bca6-4a5a-89c2-855a0634d5fe&type=display
term editor: RR, AG, YH

etoposide (Vepesid, Etopophos)-associated peripheral neurotoxicity AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Etoposide Oral Capsule
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=e28c05f0-081f-406d-8bfb-9160a6908307&type=display

flecainide (Tambocor)-associated neuropathy AE
type: Class
subclass of: neuropathy AE
subclass of: drug-associated neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Flecainide Oral Tablet
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=fa68b35e-9f50-408b-9e70-e84cecf3fd6e&type=display
term editor: RR, AG, YH

gold sodium thiomalate (Myochrysine)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Aurothiomalate Injectable Solution
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a29045b5-ba4f-407a-a0fd-3ef7e1ce64ee&type=display
term editor: RR, AG, YH

iopamidol (Isovue)-associated paresthesia AE
type: Class
subclass of: paresthesia AE
subclass of: drug-associated paresthesia AE
subclass of: Restriction
  on property: has participant
  some values from: Iopamidol Injectable Solution
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=416ab996-a2e8-4fe1-a9c9-f10b86df3bb5&type=display
term editor: RR, AG, YH

lansoprazole (Prevacid)-associated paresthesia AE
type: Class
subclass of: paresthesia AE
subclass of: drug-associated paresthesia AE
subclass of: Restriction
  on property: has participant
  some values from: lansoprazole Oral Capsule
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=924c5a35-4804-4e14-a2fc-2b84d186d257&type=display

methimazole (Tapazole)-associated paresthesia AE
type: Class
subclass of: paresthesia AE
subclass of: drug-associated paresthesia AE
subclass of: Restriction
  on property: has participant
  some values from: Methimazole Oral Tablet
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=dc92f45f-8d27-4dcb-b72d-6b8b04c6f0ce&type=display
term editor: RR, AG, YH

protriptyline (Vivactil)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: Protriptyline Oral Tablet
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=700abc58-9362-4ef5-9d7a-dd3c4d364d0a&type=display
term editor: RR, AG, YH

streptomycin-associated paresthesia AE
type: Class
subclass of: paresthesia AE
subclass of: drug-associated paresthesia AE
subclass of: Restriction
  on property: has participant
  some values from: Streptomycin Oral Capsule
term editor: RR, AG, YH
definition source: WEB: http://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=abd1f64e-4283-4370-aae8-3666316aa36e&type=display

teniposide (Vumon)-associated neurotoxicity AE
type: Class
subclass of: neurotoxicity AE
subclass of: drug-associated neurotoxicity neuropathy AE
subclass of: Restriction
  on property: has participant
  some values from: Teniposide Injectable Solution
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020119s010s011lbl.pdf
term editor: RR, AG, YH

teriflunomide (Aubagio)-associated peripheral neuropathy AE
type: Class
subclass of: peripheral neuropathy AE
subclass of: drug-associated peripheral neuropathy adverse event
subclass of: Restriction
  on property: has participant
  some values from: teriflunomide Oral Tablet
definition source: WEB: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/202992s000lbl.pdf
term editor: RR, AG, YH

bodily process
type: Class
subclass of: process
term editor: Albert Goldfain
curator notes: creation date: 2009-06-23T11:53:49Z
imported from: oae.owl
imported from: ogms.owl

pathological bodily process
type: Class
subclass of: bodily process
term editor: Albert Goldfain
definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf
definition: A bodily process that is clinically abnormal.
curator notes: creation date: 2009-06-23T11:54:29Z
imported from: oae.owl
imported from: ogms.owl

age
type: Class
subclass of: time
definition: A time quality inhering in a bearer by virtue of how long the bearer has existed.
id: PATO:0000011
imported from: oae.owl
imported from: pato.owl
in_subset: attribute slim
in_subset: scalar slim

time
type: Class
subclass of: physical quality
definition: A quality in which events occur in sequence.
id: PATO:0000165
imported from: oae.owl
imported from: pato.owl
in_subset: attribute slim
in_subset: scalar slim

physical quality
type: Class
subclass of: physical object quality
definition: A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities.
id: PATO:0001018
has_alternative_id: PATO:0002079
database_cross_reference: Wikipedia:Physical_property
has_exact_synonym: relational physical quality
imported from: oae.owl
imported from: pato.owl
imported from: uberon.owl
in_subset: attribute slim

physical object quality
type: Class
subclass of: quality
definition: A quality which inheres in a continuant.
has_alternative_id: PATO:0001237
has_alternative_id: PATO:0001238
id: PATO:0001241
comment: Relational qualities are qualities that hold between multiple entities. Normal (monadic) qualities such as the shape of a eyeball exist purely as a quality of that eyeball. A relational quality such as sensitivity to light is a quality of that eyeball (and connecting nervous system) as it relates to incoming light waves/particles.
has_exact_synonym: monadic quality of a continuant
has_narrow_synonym: monadic quality of an object
has_narrow_synonym: monadic quality of continuant
has_exact_synonym: multiply inhering quality of a physical entity
has_exact_synonym: quality of a continuant
has_exact_synonym: quality of a single physical entity
has_exact_synonym: quality of an object
has_exact_synonym: quality of continuant
database_cross_reference: snap:Quality
imported from: oae.owl
imported from: pato.owl
imported from: uberon.owl

cellularity
type: Class
subclass of: organismal quality
imported from: oae.owl
imported from: uberon.owl

multicellular
type: Class
subclass of: cellularity
imported from: oae.owl
imported from: uberon.owl

organismal quality
type: Class
subclass of: physical object quality
imported from: oae.owl
imported from: uberon.owl

peripheral nervous system
type: Class
subclass of: organ system subdivision
subclass of: Restriction
  on property: part_of
  some values from: nervous system
homology_notes: (...) specific vertebrate traits within the chordate phylum such as skeletal tissues, PNS, and spectacular head and brain development, are linked to the NC (neural crest) and its derivatives.[well established][VHOG]
definition: A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.
database_cross_reference: AAO:0000429
database_cross_reference: BAMS:PNS
database_cross_reference: BILA:0000081
database_cross_reference: BTO:0001028
database_cross_reference: CALOHA:TS-0808
database_cross_reference: EFO:0000891
database_cross_reference: EHDAA2:0001445
database_cross_reference: EHDAA:2893
database_cross_reference: EMAPA:16665
database_cross_reference: EMAPA:18370
database_cross_reference: EV:0100335
database_cross_reference: FBbt:00005098
database_cross_reference: FMA:9903
database_cross_reference: GAID:715
database_cross_reference: MA:0000218
database_cross_reference: MAT:0000338
database_cross_reference: MESH:A08.800
database_cross_reference: MIAA:0000338
external_definition: Nervous structures including ganglia outside of the central nervous system. Kimmel et al, 1995.[TAO]
has_related_synonym: PNS
external_definition: Part of nervous system in which nerves extend throughout the body outside of the brain and spinal cord.[AAO]
database_cross_reference: TAO:0000142
external_definition: The peripheral nervous system (PNS) is the part of the nervous system connected to the CNS which contains cranial nerves III - XII, spinal, peripheral and autonomic nerves. (CUMBO)
id: UBERON:0000010
database_cross_reference: UMLS:C0206417
database_cross_reference: UMLS:C1305921
database_cross_reference: VHOG:0000399
database_cross_reference: XAO:0000178
database_cross_reference: ZFA:0000142
database_cross_reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
has_related_synonym: lateral part of the basal amygdalar nucleus
has_related_synonym: lateral part of the basolateral nucleus
has_related_synonym: nucleus amygdalae basalis, pars lateralis
has_related_synonym: nucleus amygdaloideus basalis, pars lateralis magnocellularis
has_related_synonym: nucleus basalis lateralis amygdalae
has_related_synonym: pars peripherica; systema nervosum periphericum
has_obo_namespace: uberon
database_cross_reference: Peripheral nervous system
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0206417
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1305921
database_cross_reference: Peripheral Nervous System
spatially disjoint from: central nervous system
imported from: oae.owl
imported from: uberon.owl
in_subset: uberon slim
in_subset: vertebrate core
in_subset: cumbo
in_subset: efo slim
database_cross_reference: birnlex 1111
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/362292005

sense organ
type: Class
equivalent class: Class
  intersection of: organ
  intersection of: Restriction
    on property: capable_of
    some values from: detection of stimulus involved in sensory perception
subclass of: organ
subclass of: Restriction
  on property: part_of
  some values from: sensory system
subclass of: Restriction
  on property: capable_of
  some values from: detection of stimulus involved in sensory perception
database_cross_reference: AEO:0000094
definition: An organ that is capable of detection of chemical stimulus involved in sensory perception of smell.
database_cross_reference: BSA:0000121
database_cross_reference: BTO:0000202
database_cross_reference: CALOHA:TS-2043
database_cross_reference: EHDAA2:0001824
database_cross_reference: EHDAA:500
database_cross_reference: EMAPA:16192
database_cross_reference: EMAPA:35955
database_cross_reference: FBbt:00005155
database_cross_reference: GAID:63
database_cross_reference: HAO:0000930
database_cross_reference: MA:0000017
database_cross_reference: MESH:A09
has_related_synonym: Sinnesorgan
id: UBERON:0000020
database_cross_reference: UMLS:C0935626
database_cross_reference: VHOG:0001407
database_cross_reference: WBbt:0006929
has_exact_synonym: organ of sense organ system
has_exact_synonym: organ of sensory organ system
has_exact_synonym: organ of sensory system
has_exact_synonym: sense organ system organ
has_narrow_synonym: sensillum
has_related_synonym: sensor
has_exact_synonym: sensory organ
has_exact_synonym: sensory organ system organ
has_exact_synonym: sensory system organ
has_obo_namespace: uberon
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0935626
database_cross_reference: Organ of the Special Sense
imported from: oae.owl
imported from: uberon.owl
in_subset: uberon slim
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/244485009

anatomical structure
type: Class
subclass of: material anatomical entity
subclass of: Restriction
  on property: existence starts during or after
  some values from: zygote stage
subclass of: Restriction
  on property: existence ends during or before
  some values from: death stage
database_cross_reference: AAO:0010825
database_cross_reference: AEO:0000003
database_cross_reference: BILA:0000003
database_cross_reference: CARO:0000003
database_cross_reference: EHDAA2:0003003
database_cross_reference: EMAPA:0
database_cross_reference: FBbt:00007001
database_cross_reference: FMA:67135
database_cross_reference: GAID:781
database_cross_reference: HAO:0000003
database_cross_reference: MA:0003000
database_cross_reference: MESH:A13
definition: Material anatomical entity that has inherent 3D shape and is generated by coordinated expression of the organism's own genome.
database_cross_reference: TAO:0000037
database_cross_reference: TGMA:0001823
id: UBERON:0000061
database_cross_reference: VHOG:0001759
database_cross_reference: WBbt:0000100
database_cross_reference: XAO:0003000
database_cross_reference: ZFA:0000037
has_exact_synonym: biological structure
has_obo_namespace: uberon
database_cross_reference: AnatomicalStructure
imported from: oae.owl
imported from: uberon.owl
in_subset: upper level
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/362889002

organ
type: Class
subclass of: multicellular anatomical structure
subclass of: Restriction
  on property: part_of
  some values from: anatomical system
subclass of: Restriction
  on property: existence starts during or after
  some values from: organogenesis stage
subclass of: Restriction
  on property: capable_of
  some values from: biological_process
subclass of: Restriction
  on property: has boundary
  some values from: anatomical surface
definition: Anatomical structure that performs a specific function or group of functions [WP].
external_ontology_notes: CARO does not include a generic 'organ' class, only simple and compound organ
database_cross_reference: EFO:0000634
database_cross_reference: EMAPA:35949
database_cross_reference: ENVO:01000162
database_cross_reference: FMA:67498
database_cross_reference: MA:0003001
database_cross_reference: OpenCyc:Mx4rv5XMb5wpEbGdrcN5Y29ycA
database_cross_reference: OpenCyc:Mx4rwP3iWpwpEbGdrcN5Y29ycA
external_definition: Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
id: UBERON:0000062
database_cross_reference: UMLS:C0178784
database_cross_reference: WBbt:0003760
has_related_synonym: anatomical unit
has_related_synonym: body organ
has_related_synonym: element
has_obo_namespace: uberon
database_cross_reference: Organ (anatomy)
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0178784
database_cross_reference: Organ
RO_0002161: NCBITaxon_110815
imported from: oae.owl
imported from: uberon.owl
in_subset: upper level
database_cross_reference: birnlex 4
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/272625005

fully formed stage
type: Class
subclass of: life cycle stage
subclass of: Restriction
  on property: preceded_by
  some values from: organogenesis stage
subclass of: Restriction
  on property: part_of
  some values from: post-embryonic stage
subclass of: Restriction
  on property: precedes
  some values from: death stage
database_cross_reference: BTO:0001043
database_cross_reference: BilaDO:0000004
database_cross_reference: EFO:0001272
database_cross_reference: FBdv:00005369
definition: The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage.
id: UBERON:0000066
database_cross_reference: WBls:0000041
database_cross_reference: XtroDO:0000084
has_broad_synonym: adult stage
has_exact_synonym: fully formed animal stage
has_exact_synonym: juvenile-adult stage
has_obo_namespace: uberon
imported from: oae.owl
imported from: uberon.owl
in_subset: efo slim

embryo stage part
type: Class
equivalent class: Class
  intersection of: life cycle stage
  intersection of: Restriction
    on property: part_of
    some values from: embryo stage
subclass of: life cycle stage
subclass of: Restriction
  on property: part_of
  some values from: embryo stage
definition: A stage that is part of the embryo stage.
id: UBERON:0000067
has_exact_synonym: embryonic stage part
has_obo_namespace: uberon
imported from: oae.owl
imported from: uberon.owl
in_subset: grouping class

embryo stage
type: Class
subclass of: life cycle stage
subclass of: Restriction
  on property: precedes
  some values from: fully formed stage
subclass of: Restriction
  on property: simultaneous_with
  some values from: embryo development
subclass of: Restriction
  on property: part_of
  some values from: life cycle
subclass of: Restriction
  on property: precedes
  some values from: post-embryonic stage
definition: A life cycle stage that starts with fertilization and ends with the fully formed embryo.
database_cross_reference: BilaDO:0000002
database_cross_reference: EV:0300001
database_cross_reference: FBdv:00005289
database_cross_reference: HsapDv:0000002
database_cross_reference: MmusDv:0000002
database_cross_reference: OGES:000000
database_cross_reference: OGES:000022
id: UBERON:0000068
database_cross_reference: WBls:0000003
database_cross_reference: WBls:0000092
database_cross_reference: WBls:0000102
database_cross_reference: XAO:1000012
has_related_synonym: embryogenesis
has_exact_synonym: embryonic stage
has_obo_namespace: uberon
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/296280003

death stage
type: Class
subclass of: life cycle stage
subclass of: Restriction
  on property: part_of
  some values from: life cycle
subclass of: Restriction
  on property: simultaneous_with
  some values from: death
subclass of: Restriction
  on property: ends
  some values from: life cycle
definition: End of the life of an organism.
id: UBERON:0000071
database_cross_reference: XAO:0000437
database_cross_reference: XtroDO:0000085
has_related_synonym: death
external_ontology_notes: ncit:Death is an outcome
has_obo_namespace: uberon
imported from: oae.owl
imported from: uberon.owl

post-embryonic stage
type: Class
subclass of: life cycle stage
subclass of: Restriction
  on property: simultaneous_with
  some values from: post-embryonic development
subclass of: Restriction
  on property: preceded_by
  some values from: embryo stage
subclass of: Restriction
  on property: part_of
  some values from: life cycle
database_cross_reference: BilaDO:0000003
taxon_notes: In birds, the postnatal stage begins when the beak penetrates the shell (i.e., external pipping) (Brown et al. 1997)
database_cross_reference: OGES:000010
database_cross_reference: OGES:000014
database_cross_reference: OGES:000024
id: UBERON:0000092
database_cross_reference: WBls:0000022
database_cross_reference: WBls:0000093
database_cross_reference: WBls:0000103
has_narrow_synonym: post-hatching stage
has_related_synonym: postembryonic
has_exact_synonym: postembryonic stage
definition: stage succeeding embryo, including mature structure
has_obo_namespace: uberon
imported from: oae.owl
imported from: uberon.owl

life cycle
type: Class
subclass of: life cycle stage
definition: An entire span of an organism's life, commencing with the zygote stage and ending in the death of the organism.
database_cross_reference: FBdv:00000000
database_cross_reference: HsapDv:0000001
database_cross_reference: MmusDv:0000001
database_cross_reference: OGES:000011
id: UBERON:0000104
has_exact_synonym: life
has_exact_synonym: lifespan
has_obo_namespace: uberon
database_cross_reference: Life
imported from: oae.owl
imported from: uberon.owl
in_subset: upper level

life cycle stage
type: Class
subclass of: process
definition: A spatiotemporal region encompassing some part of the life cycle of an organism.
database_cross_reference: BILS:0000105
database_cross_reference: EFO:0000399
database_cross_reference: FBdv:00007012
database_cross_reference: HsapDv:0000000
database_cross_reference: MmusDv:0000000
database_cross_reference: OlatDv:0000010
database_cross_reference: PdumDv:0000090
id: UBERON:0000105
database_cross_reference: WBls:0000002
database_cross_reference: XAO:1000000
database_cross_reference: ZFS:0000000
database_cross_reference: ZFS:0100000
has_narrow_synonym: developmental stage
has_narrow_synonym: stage
has_obo_namespace: uberon
editor note: we map the ZFS unknown stage here as it is logically equivalent to saying *some* life cycle stage
database_cross_reference: Developmental Stage
imported from: oae.owl
imported from: uberon.owl
in_subset: upper level
in_subset: efo slim

zygote stage
type: Class
subclass of: embryo stage part
subclass of: Restriction
  on property: starts
  some values from: life cycle
subclass of: Restriction
  on property: part_of
  some values from: embryo stage
has_exact_synonym: 1-cell stage
definition: A stage at which the organism is a single cell produced by means of sexual reproduction.
homology_notes: As in all metazoans, eumetazoan development begins with a fertilized egg, or zygote.[well established][VHOG]
database_cross_reference: BILS:0000106
database_cross_reference: BilaDO:0000005
database_cross_reference: EFO:0001322
database_cross_reference: EHDAA:27
database_cross_reference: EMAPA:16033
database_cross_reference: FBdv:00005288
database_cross_reference: PdumDv:0000100
id: UBERON:0000106
database_cross_reference: VHOG:0000745
database_cross_reference: XAO:1000001
database_cross_reference: ZFS:0000001
has_exact_synonym: fertilized egg stage
has_related_synonym: fertilized egg stage
has_exact_synonym: one cell stage
has_related_synonym: one-cell stage
has_obo_namespace: uberon
has_related_synonym: zygote
has_related_synonym: zygotum
database_cross_reference: Zygote
imported from: oae.owl
imported from: uberon.owl
in_subset: efo slim

cleavage stage
type: Class
equivalent class: Class
  intersection of: life cycle stage
  intersection of: Restriction
    on property: simultaneous_with
    some values from: embryonic cleavage
subclass of: embryo stage part
subclass of: Restriction
  on property: part_of
  some values from: embryo stage
subclass of: Restriction
  on property: immediately_preceded_by
  some values from: zygote stage
subclass of: Restriction
  on property: simultaneous_with
  some values from: embryonic cleavage
database_cross_reference: BILS:0000107
database_cross_reference: BilaDO:0000006
database_cross_reference: EFO:0001290
database_cross_reference: FBdv:00000054
database_cross_reference: MESH:A16.254.270
database_cross_reference: MmusDv:0000004
database_cross_reference: OGES:000015
database_cross_reference: OGES:000020
database_cross_reference: PdumDv:0000200
definition: The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula.
id: UBERON:0000107
database_cross_reference: XAO:1000004
database_cross_reference: ZFS:0000046
has_obo_namespace: uberon
database_cross_reference: Cleavage (embryo)
imported from: oae.owl
imported from: uberon.owl
in_subset: efo slim

blastula stage
type: Class
subclass of: embryo stage part
subclass of: Restriction
  on property: preceded_by
  some values from: cleavage stage
subclass of: Restriction
  on property: part_of
  some values from: embryo stage
definition: An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence.
database_cross_reference: BILS:0000108
database_cross_reference: BilaDO:0000007
database_cross_reference: EFO:0001282
database_cross_reference: HsapDv:0000006
database_cross_reference: MmusDv:0000007
database_cross_reference: OGES:000003
database_cross_reference: OGES:000016
database_cross_reference: OGES:000021
database_cross_reference: OpenCyc:Mx4rEetFnKP2EdqAAAACs4vPlg
id: UBERON:0000108
database_cross_reference: WBls:0000005
database_cross_reference: XAO:1000003
database_cross_reference: ZFS:0000045
editor note: consider adding a preceding stage 'morula stage' as part of cleavage
has_obo_namespace: uberon
database_cross_reference: Blastula
imported from: oae.owl
imported from: uberon.owl
in_subset: efo slim

gastrula stage
type: Class
subclass of: embryo stage part
subclass of: Restriction
  on property: preceded_by
  some values from: blastula stage
subclass of: Restriction
  on property: only in taxon
  some values from: Eumetazoa
subclass of: Restriction
  on property: simultaneous_with
  some values from: gastrulation
subclass of: Restriction
  on property: part_of
  some values from: embryo stage
definition: A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
database_cross_reference: BILS:0000109
database_cross_reference: BilaDO:0000008
database_cross_reference: EFO:0001296
database_cross_reference: FBdv:00005317
database_cross_reference: HsapDv:0000010
database_cross_reference: MmusDv:0000013
database_cross_reference: OGES:000004
database_cross_reference: OGES:000019
id: UBERON:0000109
database_cross_reference: WBls:0000010
database_cross_reference: XAO:1000005
database_cross_reference: ZFS:0000047
has_related_synonym: blastocystis trilaminaris stage
has_related_synonym: trilaminar blastocyst stage
has_related_synonym: trilaminar blastoderm stage
has_related_synonym: trilaminar disk stage
has_related_synonym: trilaminar germ stage
has_related_synonym: trilaminar stage
has_obo_namespace: uberon
imported from: oae.owl
imported from: uberon.owl
in_subset: efo slim

neurula stage
type: Class
subclass of: embryo stage part
subclass of: Restriction
  on property: part_of
  some values from: embryo stage
subclass of: Restriction
  on property: preceded_by
  some values from: gastrula stage
subclass of: Restriction
  on property: simultaneous_with
  some values from: neural tube formation
subclass of: Restriction
  on property: only in taxon
  some values from: Eumetazoa
database_cross_reference: BILS:0000110
database_cross_reference: BilaDO:0000009
database_cross_reference: HsapDv:0000012
database_cross_reference: MmusDv:0000017
definition: Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.
id: UBERON:0000110
database_cross_reference: XAO:1000006
has_obo_namespace: uberon
imported from: oae.owl
imported from: uberon.owl

organogenesis stage
type: Class
subclass of: embryo stage part
subclass of: Restriction
  on property: simultaneous_with
  some values from: organ development
subclass of: Restriction
  on property: preceded_by
  some values from: neurula stage
subclass of: Restriction
  on property: only in taxon
  some values from: Eumetazoa
subclass of: Restriction
  on property: part_of
  some values from: embryo stage
definition: A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism.
database_cross_reference: BILS:0000111
database_cross_reference: BilaDO:0000010
database_cross_reference: HsapDv:0000015
database_cross_reference: MmusDv:0000018
database_cross_reference: OGES:000005
database_cross_reference: OGES:000032
id: UBERON:0000111
has_related_synonym: segmentation stage
has_obo_namespace: uberon
database_cross_reference: Organogenesis
imported from: oae.owl
imported from: uberon.owl

blastula
type: Class
equivalent class: Class
  intersection of: multi-cellular organism
  intersection of: Restriction
    on property: existence starts and ends during
    some values from: blastula stage
subclass of: embryo
subclass of: Restriction
  on property: existence starts and ends during
  some values from: blastula stage
subclass of: Restriction
  on property: develops_from
  some values from: cleaving embryo
database_cross_reference: BILA:0000059
database_cross_reference: BTO:0000128
database_cross_reference: GAID:1294
database_cross_reference: MESH:A16.254.270.274
database_cross_reference: OGEM:000006
database_cross_reference: OpenCyc:Mx4rEetFnKP2EdqAAAACs4vPlg
definition: Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence.
editor note: TODO - check relationship with epiblast. Note in FMA this is not a subclass of embryo, but in uberon embryo is the whole organism from zygote onwards and thus includes the blastula
id: UBERON:0000307
has_alternative_id: UBERON:0007011
has_related_synonym: blastosphere
has_exact_synonym: blastula embryo
has_obo_namespace: uberon
database_cross_reference: Blastula
imported from: oae.owl
imported from: uberon.owl
in_subset: inconsistent with fma

material anatomical entity
type: Class
subclass of: anatomical entity
database_cross_reference: AAO:0010264
database_cross_reference: AEO:0000006
definition: Anatomical entity that has mass.
database_cross_reference: BILA:0000006
database_cross_reference: CARO:0000006
database_cross_reference: EHDAA2:0003006
database_cross_reference: FBbt:00007016
database_cross_reference: FMA:67165
database_cross_reference: HAO:0000006
database_cross_reference: TAO:0001836
database_cross_reference: TGMA:0001826
id: UBERON:0000465
database_cross_reference: VHOG:0001721
has_obo_namespace: uberon
imported from: oae.owl
imported from: uberon.owl
in_subset: upper level

immaterial anatomical entity
type: Class
subclass of: anatomical entity
database_cross_reference: AAO:0010265
database_cross_reference: AEO:0000007
definition: Anatomical entity that has no mass.
database_cross_reference: BILA:0000007
database_cross_reference: CARO:0000007
database_cross_reference: EHDAA2:0003007
database_cross_reference: FBbt:00007015
database_cross_reference: FMA:67112
database_cross_reference: HAO:0000007
database_cross_reference: TAO:0001835
database_cross_reference: TGMA:0001827
id: UBERON:0000466
database_cross_reference: VHOG:0001727
has_exact_synonym: immaterial physical anatomical entity
has_obo_namespace: uberon
imported from: oae.owl
imported from: uberon.owl
in_subset: disjointness axiom removed
in_subset: upper level

anatomical system
type: Class
subclass of: anatomical group
subclass of: Restriction
  on property: part_of
  some values from: multi-cellular organism
subclass of: Restriction
  on property: existence starts during or after
  some values from: organogenesis stage
database_cross_reference: AAO:0000007
database_cross_reference: AEO:0000011
definition: Anatomical group that is has as its parts distinct anatomical structures interconnected by anatomical structures at a lower level of granularity[CARO]. A group of organs that work together to perform a certain task [Wikipedia].
database_cross_reference: BILA:0000011
database_cross_reference: BSA:0000049
database_cross_reference: CALOHA:TS-2088
database_cross_reference: CARO:0000011
database_cross_reference: EHDAA2:0003011
database_cross_reference: EHDAA:392
database_cross_reference: EMAPA:16103
database_cross_reference: EV:0100000
database_cross_reference: FBbt:00004856
database_cross_reference: FMA:7149
database_cross_reference: HAO:0000011
database_cross_reference: MA:0000003
database_cross_reference: OpenCyc:Mx4rCWM0QCtDEdyAAADggVbxzQ
database_cross_reference: TAO:0001439
database_cross_reference: TGMA:0001831
id: UBERON:0000467
database_cross_reference: UMLS:C0460002
database_cross_reference: VHOG:0001725
database_cross_reference: WBbt:0005746
database_cross_reference: WBbt:0005763
database_cross_reference: XAO:0003002
database_cross_reference: ZFA:0001439
has_exact_synonym: body system
database_cross_reference: galen:AnatomicalSystem
has_exact_synonym: organ system
has_broad_synonym: system
has_obo_namespace: uberon
database_cross_reference: Organ system
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0460002
database_cross_reference: Organ System
imported from: oae.owl
imported from: uberon.owl
in_subset: uberon slim
in_subset: upper level
database_cross_reference: birnlex 14
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/278195005

multi-cellular organism
type: Class
subclass of: multicellular anatomical structure
database_cross_reference: AAO:0010026
database_cross_reference: AEO:0000191
definition: Anatomical structure that is an individual member of a species and consists of more than one cell.
database_cross_reference: BILA:0000012
database_cross_reference: BSA:0000038
database_cross_reference: BTO:0000042
database_cross_reference: CARO:0000012
database_cross_reference: EFO:0002906
database_cross_reference: EHDAA2:0003103
database_cross_reference: EHDAA2:0003191
database_cross_reference: EHDAA:1
database_cross_reference: EHDAA:9178
database_cross_reference: EMAPA:25765
database_cross_reference: EV:0100016
database_cross_reference: FBbt:00000001
database_cross_reference: FMA:256135
database_cross_reference: HAO:0000012
has_related_synonym: Koerper
database_cross_reference: TADS:0000001
database_cross_reference: TAO:0001094
database_cross_reference: TGMA:0001832
editor note: TODO - split body and mc organism? body continues after death stage
id: UBERON:0000468
database_cross_reference: VHOG:0000671
database_cross_reference: WBbt:0007833
database_cross_reference: XAO:0003004
database_cross_reference: ZFA:0001094
has_narrow_synonym: animal
has_related_synonym: body
database_cross_reference: galen:Organism
has_exact_synonym: organism
has_relational_adjective: organismal
has_obo_namespace: uberon
has_related_synonym: whole body
has_exact_synonym: whole organism
database_cross_reference: Multi-cellular organism
database_cross_reference: Whole Organism
imported from: oae.owl
imported from: uberon.owl
in_subset: uberon slim
in_subset: upper level
in_subset: efo slim
database_cross_reference: birnlex 18
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/243928005

anatomical cluster
type: Class
subclass of: anatomical group
database_cross_reference: AAO:0010009
database_cross_reference: AEO:0000041
definition: Anatomical group that has its parts adjacent to one another.
database_cross_reference: BILA:0000041
database_cross_reference: CARO:0000041
database_cross_reference: EHDAA2:0003041
database_cross_reference: FBbt:00007277
database_cross_reference: FMA:49443
database_cross_reference: HAO:0000041
database_cross_reference: TADS:0000605
database_cross_reference: TAO:0001478
database_cross_reference: TGMA:0001842
id: UBERON:0000477
database_cross_reference: VHOG:0001737
database_cross_reference: XAO:0003160
database_cross_reference: ZFA:0001478
has_obo_namespace: uberon
imported from: oae.owl
imported from: uberon.owl
in_subset: disjointness axiom removed
in_subset: upper level

tissue
type: Class
subclass of: multicellular anatomical structure
subclass of: Restriction
  on property: part_of
  some values from: multi-cellular organism
subclass of: Restriction
  on property: has_part
  some values from: extracellular matrix
database_cross_reference: AAO:0000607
database_cross_reference: AAO:0010054
database_cross_reference: AEO:0000043
database_cross_reference: BILA:0000043
database_cross_reference: CALOHA:TS-2090
database_cross_reference: CARO:0000043
database_cross_reference: EHDAA2:0003043
database_cross_reference: EMAPA:35868
database_cross_reference: FBbt:00007003
database_cross_reference: FMA:9637
database_cross_reference: HAO:0000043
database_cross_reference: MA:0003002
database_cross_reference: MESH:A10
definition: Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation.
database_cross_reference: TAO:0001477
database_cross_reference: TGMA:0001844
id: UBERON:0000479
database_cross_reference: UMLS:C0040300
database_cross_reference: VHOG:0001757
database_cross_reference: WBbt:0005729
database_cross_reference: XAO:0003040
database_cross_reference: ZFA:0001477
editor note: changed label and definition to reflect CARO2
database_cross_reference: galen:Tissue
has_exact_synonym: portion of tissue
has_narrow_synonym: simple tissue
has_exact_synonym: tissue portion
has_obo_namespace: uberon
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0040300
database_cross_reference: Tissue
imported from: oae.owl
imported from: uberon.owl
in_subset: upper level
database_cross_reference: birnlex 19

anatomical group
type: Class
subclass of: anatomical structure
subclass of: Restriction
  on property: part_of
  some values from: multi-cellular organism
database_cross_reference: AAO:0010008
database_cross_reference: AEO:0000054
definition: Anatomical structure consisting of at least two non-overlapping organs, multi-tissue aggregates or portion of tissues or cells of different types that does not constitute an organism, organ, multi-tissue aggregate, or portion of tissue.
database_cross_reference: BILA:0000054
database_cross_reference: CARO:0000054
database_cross_reference: EHDAA2:0003054
database_cross_reference: HAO:0000054
database_cross_reference: TAO:0001512
database_cross_reference: TGMA:0001846
id: UBERON:0000480
database_cross_reference: VHOG:0001724
database_cross_reference: XAO:0003001
database_cross_reference: ZFA:0001512
has_obo_namespace: uberon
imported from: oae.owl
imported from: uberon.owl
in_subset: upper level

embryo
type: Class
equivalent class: Class
  intersection of: multi-cellular organism
  intersection of: Restriction
    on property: existence starts with
    some values from: embryo stage
  intersection of: Restriction
    on property: existence ends with
    some values from: embryo stage
subclass of: multi-cellular organism
subclass of: Restriction
  on property: existence starts with
  some values from: embryo stage
subclass of: Restriction
  on property: existence ends with
  some values from: embryo stage
database_cross_reference: AAO:0011035
database_cross_reference: AEO:0000169
definition: Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
database_cross_reference: BILA:0000056
database_cross_reference: BSA:0000039
database_cross_reference: BTO:0000379
database_cross_reference: CALOHA:TS-0229
database_cross_reference: EFO:0001367
database_cross_reference: EHDAA2:0000002
database_cross_reference: EHDAA2_RETIRED:0003236
database_cross_reference: EHDAA:38
database_cross_reference: EMAPA:16039
database_cross_reference: FBbt:00000052
database_cross_reference: FMA:69068
database_cross_reference: GAID:963
database_cross_reference: MAT:0000226
database_cross_reference: MESH:A16.254
database_cross_reference: MIAA:0000019
database_cross_reference: OGEM:000001
comment: Obsoleted in ZFA. Note that embryo is not classified as an embryonic structure - an embryonic structure is only the parts of an embryo
database_cross_reference: OpenCyc:Mx4rwP1ceZwpEbGdrcN5Y29ycA
id: UBERON:0000922
database_cross_reference: UMLS:C0013935
database_cross_reference: VHOG:0001766
database_cross_reference: XAO:0000113
database_cross_reference: ZFA:0000103
has_related_synonym: developing organism
has_related_synonym: developmental tissue
has_relational_adjective: embryonic
has_exact_synonym: embryonic organism
has_obo_namespace: uberon
database_cross_reference: Embryo
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0013935
database_cross_reference: Category:Embryonic organism
imported from: oae.owl
imported from: uberon.owl
in_subset: uberon slim
in_subset: vertebrate core
in_subset: efo slim
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/57991002

germ layer
type: Class
subclass of: germ layer / neural crest
subclass of: Restriction
  on property: only in taxon
  some values from: Eumetazoa
subclass of: Restriction
  on property: part_of
  some values from: embryo
subclass of: Restriction
  on property: develops_from
  some values from: epiblast (generic)
definition: A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm.
database_cross_reference: AAO:0000480
database_cross_reference: BILA:0000035
database_cross_reference: BTO:0000556
comment: Classically the germ layers are ectoderm, mesoderm and endoderm. Alternatively: primary = ectoderm, endoderm; secondary=mesoderm; tertiary=dorsal mesoderm, NC[UBERONREF:0000002]
database_cross_reference: FBbt:00000110
database_cross_reference: FMA:69069
database_cross_reference: GAID:1303
database_cross_reference: MESH:A16.254.425
database_cross_reference: TAO:0001122
homology_notes: The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]
id: UBERON:0000923
database_cross_reference: UMLS:C0920502
database_cross_reference: UMLS:C1708239
database_cross_reference: VHOG:0001223
database_cross_reference: XAO:0003011
database_cross_reference: ZFA:0001122
has_related_synonym: embryonic germ layer
has_related_synonym: embryonic germ layers
has_broad_synonym: embryonic tissue
has_exact_synonym: germinal layer
has_narrow_synonym: primary germ layer
has_obo_namespace: uberon
database_cross_reference: Germ layer
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0920502
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1708239
database_cross_reference: Embryonic Tissue
database_cross_reference: Germinal Layer
imported from: oae.owl
imported from: uberon.owl
in_subset: uberon slim
in_subset: vertebrate core

ectoderm
type: Class
subclass of: germ layer
subclass of: Restriction
  on property: immediate transformation of
  some values from: presumptive ectoderm
subclass of: Restriction
  on property: has_part
  some values from: ectodermal cell
database_cross_reference: AAO:0000137
database_cross_reference: BILA:0000036
database_cross_reference: BTO:0000315
database_cross_reference: CALOHA:TS-0216
database_cross_reference: EFO:0000414
database_cross_reference: EHDAA2:0000428
database_cross_reference: EMAPA:16069
database_cross_reference: EV:0100003
database_cross_reference: FBbt:00000111
database_cross_reference: FMA:69070
database_cross_reference: GAID:1304
database_cross_reference: MAT:0000155
database_cross_reference: MAT:0000173
database_cross_reference: MESH:A16.254.425.273
database_cross_reference: MIAA:0000173
definition: Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue.
external_definition: Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO]
database_cross_reference: TAO:0000016
homology_notes: The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]
id: UBERON:0000924
database_cross_reference: UMLS:C0013574
database_cross_reference: VHOG:0000153
database_cross_reference: XAO:0000001
database_cross_reference: ZFA:0000016
has_relational_adjective: ectodermal
has_exact_synonym: embryonic ectoderm
has_obo_namespace: uberon
database_cross_reference: Ectoderm
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0013574
imported from: oae.owl
imported from: uberon.owl
in_subset: uberon slim
in_subset: vertebrate core
in_subset: efo slim
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/362851007

eye
type: Class
subclass of: sense organ
subclass of: Restriction
  on property: has_part
  some values from: photoreceptor cell
subclass of: Restriction
  on property: part_of
  some values from: visual system
subclass of: Restriction
  on property: capable_of
  some values from: detection of visible light
subclass of: Restriction
  on property: has_part
  some values from: visual pigment cell
definition: An organ that detects light.
database_cross_reference: BILA:0000017
database_cross_reference: BTO:0000439
database_cross_reference: CALOHA:TS-0309
database_cross_reference: EFO:0000827
database_cross_reference: EV:0100336
database_cross_reference: FBbt:00005162
database_cross_reference: GAID:69
database_cross_reference: MAT:0000140
database_cross_reference: MESH:A01.456.505.420
database_cross_reference: MIAA:0000140
structure_notes: Note that whilst this is classified as an organ, it is in fact more of a unit composed of different structures: in Drosophila, it includes the interommatidial bristle as a part; we consider here the vertebrate eye to include the eyeball/eye proper as a part, with the eye having as parts (when present): eyelids, conjuctiva,
database_cross_reference: OpenCyc:Mx4rvViTvpwpEbGdrcN5Y29ycA
curator notes: This class encompasses a variety of light-detecting structures from different phyla with no implication of homology, from the compound insect eye to the vertebrate camera-type eye (distinct classes are provided for each)
id: UBERON:0000970
has_related_synonym: light-detecting organ
has_relational_adjective: ocular
has_relational_adjective: optic
has_obo_namespace: uberon
has_related_synonym: visual apparatus
database_cross_reference: Eye
imported from: oae.owl
imported from: uberon.owl
in_subset: functional classification
in_subset: major organ
in_subset: organ slim
in_subset: uberon slim
in_subset: efo slim

nervous system
type: Class
subclass of: anatomical system
subclass of: Restriction
  on property: capable_of
  some values from: neurological system process
subclass of: Restriction
  on property: has_part
  some values from: neuron
subclass of: Restriction
  on property: only in taxon
  some values from: Eumetazoa
subclass of: Restriction
  on property: existence ends during
  some values from: fully formed stage
subclass of: Restriction
  on property: immediate transformation of
  some values from: future nervous system
subclass of: Restriction
  on property: composed_primarily_of
  some values from: neural cell
external_definition: A regulatory system of the body that consists of neurons and neuroglial cells. The nervous system is divided into two parts, the central nervous system (CNS) and the peripheral nervous system (PNS). (Source: BioGlossary, www.Biology-Text.com)[TAO]
database_cross_reference: AAO:0000324
external_definition: Anatomical system consisting of nerve bodies and nerve fibers which regulate the response of the body to external and internal stimuli.[AAO]
database_cross_reference: BILA:0000079
database_cross_reference: BTO:0001484
database_cross_reference: CALOHA:TS-1313
database_cross_reference: EFO:0000802
database_cross_reference: EHDAA2:0001246
database_cross_reference: EHDAA:826
database_cross_reference: EMAPA:16469
database_cross_reference: EV:0100162
database_cross_reference: FBbt:00005093
database_cross_reference: FMA:7157
database_cross_reference: GAID:466
database_cross_reference: MA:0000016
database_cross_reference: MAT:0000026
database_cross_reference: MESH:A08
database_cross_reference: MIAA:0000026
has_related_synonym: Nervensystem
homology_notes: Nervous systems evolved in the ancestor of Eumetazoa.[well established][VHOG]
database_cross_reference: OpenCyc:Mx4rvViT_pwpEbGdrcN5Y29ycA
database_cross_reference: TAO:0000396
definition: The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO].
id: UBERON:0001016
database_cross_reference: UMLS:C0027763
database_cross_reference: VHOG:0000402
database_cross_reference: WBbt:0005735
database_cross_reference: XAO:0000177
database_cross_reference: ZFA:0000396
has_narrow_synonym: nerve net
has_relational_adjective: nervous
has_relational_adjective: neural
axiom_lost_from_external_ontology: relationship type change: differentiates_from ectoderm (AAO:0000137) CHANGED TO: develops_from ectoderm (UBERON:0000924)[AAO]
has_related_synonym: systema nervosum
has_obo_namespace: uberon
database_cross_reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database_cross_reference: Nervous system
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0027763
database_cross_reference: Nervous System
imported from: oae.owl
imported from: uberon.owl
in_subset: uberon slim
in_subset: vertebrate core
in_subset: cumbo
in_subset: efo slim
database_cross_reference: birnlex 844
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/278196006

central nervous system
type: Class
subclass of: ectoderm-derived structure
subclass of: organ system subdivision
subclass of: Restriction
  on property: only in taxon
  some values from: Bilateria
subclass of: Restriction
  on property: immediate transformation of
  some values from: future central nervous system
subclass of: Restriction
  on property: part_of
  some values from: nervous system
homology_notes: (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2); Taken together, our data make a very strong case that the complex molecular mediolateral architecture of the developing trunk CNS (central nervous system), as shared between Platynereis and vertebrates, was already present in their last common ancestor, Urbilateria. The concept of bilaterian nervous system centralization implies that neuron types concentrate on one side of the trunk, as is the case in vertebrates and many invertebrates including Platynereis, where they segregate and become spatially organized (as opposed to a diffuse nerve net). Our data reveal that a large part of the spatial organization of the annelid and vertebrate CNS was already present in their last common ancestor, which implies that Urbilateria had already possessed a CNS (reference 3).[well established][VHOG]
database_cross_reference: AAO:0000090
database_cross_reference: BAMS:CNS
database_cross_reference: BILA:0000080
database_cross_reference: BTO:0000227
database_cross_reference: CALOHA:TS-0150
has_exact_synonym: CNS
database_cross_reference: EFO:0000908
database_cross_reference: EHDAA2:0000225
database_cross_reference: EHDAA:828
database_cross_reference: EMAPA:16470
database_cross_reference: EMAPA:16754
database_cross_reference: EV:0100163
database_cross_reference: FBbt:00005094
database_cross_reference: FMA:55675
database_cross_reference: GAID:570
database_cross_reference: MA:0000167
database_cross_reference: MAT:0000457
database_cross_reference: MESH:A08.186
database_cross_reference: OpenCyc:Mx4rvzYt3pwpEbGdrcN5Y29ycA
external_definition: Part of the nervous system which includes the brain and spinal cord.[AAO]
database_cross_reference: TAO:0000012
external_definition: The brain and spinal cord. Kimmel et al, 1995.[TAO]
external_definition: The central nervous system (CNS) is the part of the nervous system which includes the brain, spinal cord, and nerve cell layer of the retina (CUMBO).
definition: The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord[GO].
id: UBERON:0001017
database_cross_reference: UMLS:C0927232
database_cross_reference: VHOG:0000293
database_cross_reference: XAO:0000215
database_cross_reference: ZFA:0000012
has_related_synonym: basal nucleus of the amygdala
has_related_synonym: basolateral nucleus of amygdala
has_related_synonym: basolateral nucleus of the amygdala
has_narrow_synonym: cerebrospinal axis
database_cross_reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
has_exact_synonym: neuraxis
has_related_synonym: nucleus amygdalae basalis
has_related_synonym: nucleus amygdaloideus basalis
has_related_synonym: nucleus amygdaloideus basolateralis
has_related_synonym: nucleus basalis amygdalae
has_exact_synonym: systema nervosum centrale
has_obo_namespace: uberon
database_cross_reference: Central nervous system
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0927232
database_cross_reference: Central Nervous System
RO_0002161: NCBITaxon_147099
imported from: oae.owl
imported from: uberon.owl
in_subset: uberon slim
in_subset: vertebrate core
in_subset: cumbo
in_subset: efo slim
database_cross_reference: birnlex 1099
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/278199004

sensory system
type: Class
subclass of: anatomical system
subclass of: Restriction
  on property: capable_of_part_of
  some values from: sensory perception
subclass of: Restriction
  on property: part_of
  some values from: entire sense organ system
subclass of: Restriction
  on property: has_part
  some values from: Restriction
    on property: part_of
    some values from: nervous system
database_cross_reference: AAO:0000555
homology_notes: An early step in the evolution of neural crest, therefore, may have been the origin of a specific dorsal neural cell population contributing to sensory processing; this would predate the divergence of the amphioxus and vertebrate lineages.[well established][VHOG]
definition: Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information.
database_cross_reference: BAMS:SEN
database_cross_reference: BILA:0000099
database_cross_reference: EFO:0000805
database_cross_reference: EHDAA2:0003094
database_cross_reference: EMAPA:16192
database_cross_reference: FBbt:00005827
database_cross_reference: FMA:75259
database_cross_reference: MA:0002442
database_cross_reference: MAT:0000031
database_cross_reference: MIAA:0000031
database_cross_reference: TAO:0000282
id: UBERON:0001032
database_cross_reference: VHOG:0001674
database_cross_reference: XAO:0003194
database_cross_reference: ZFA:0000282
external_ontology_notes: note the distinct between entire sensory system and individual system. this reconciles is_a and part_of distinctions between ssAOs
has_exact_synonym: organa sensuum
has_related_synonym: organa sensuum
has_exact_synonym: sense organ subsystem
has_exact_synonym: sense organs
has_exact_synonym: sense organs set
has_related_synonym: sensory organ system
has_exact_synonym: sensory subsystem
has_exact_synonym: sensory systems
has_related_synonym: set of sense organs
has_obo_namespace: uberon
database_cross_reference: Sensory system
imported from: oae.owl
imported from: uberon.owl
in_subset: uberon slim
in_subset: vertebrate core
in_subset: efo slim
database_cross_reference: nlx anat 090816

anatomical entity
type: Class
subclass of: material entity
database_cross_reference: AAO:0010841
database_cross_reference: AEO:0000000
database_cross_reference: BILA:0000000
definition: Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species.
database_cross_reference: CARO:0000000
database_cross_reference: EHDAA2:0002229
database_cross_reference: FBbt:10000000
database_cross_reference: FBbt_root:00000000
database_cross_reference: FMA:62955
database_cross_reference: HAO:0000000
database_cross_reference: MA:0000001
database_cross_reference: TAO:0100000
database_cross_reference: TGMA:0001822
id: UBERON:0001062
database_cross_reference: UMLS:C1515976
database_cross_reference: XAO:0000000
database_cross_reference: ZFA:0100000
has_obo_namespace: uberon
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1515976
database_cross_reference: Anatomic Structure System or Substance
imported from: oae.owl
imported from: uberon.owl
in_subset: upper level
database_cross_reference: birnlex 6

embryonic structure
type: Class
equivalent class: Class
  intersection of: anatomical structure
  intersection of: Restriction
    on property: part_of
    some values from: embryo
subclass of: anatomical structure
subclass of: developing anatomical structure
subclass of: Restriction
  on property: part_of
  some values from: embryo
database_cross_reference: AAO:0000138
definition: Anatomical structure that is part of an embryo.
external_definition: Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[AAO]
external_definition: Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[TAO]
external_definition: Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[VSAO]
database_cross_reference: BILA:0000034
database_cross_reference: BTO:0000174
database_cross_reference: CALOHA:TS-2110
database_cross_reference: EFO:0000461
database_cross_reference: FBbt:00004208
database_cross_reference: FMA:69067
database_cross_reference: GAID:407
database_cross_reference: MESH:A16
database_cross_reference: RETIRED_EHDAA2:0003169
database_cross_reference: TAO:0001105
id: UBERON:0002050
database_cross_reference: UMLS:C0013948
database_cross_reference: VSAO:0000178
database_cross_reference: XAO:0003042
database_cross_reference: ZFA:0001105
has_exact_synonym: developing embryonic structure
has_related_synonym: developing structure
has_related_synonym: embryonale Struktur
has_exact_synonym: embryonic anatomical structure
external_ontology_notes: in FMA embryo is_a embryonic structure
has_obo_namespace: uberon
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0013948
database_cross_reference: Embryonic Structure
imported from: oae.owl
imported from: uberon.owl
in_subset: inconsistent with fma
in_subset: vertebrate core
in_subset: efo slim
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/667009

visual system
type: Class
subclass of: sensory system
subclass of: Restriction
  on property: capable_of
  some values from: visual perception
database_cross_reference: AAO:0000632
database_cross_reference: BILA:0000140
database_cross_reference: FMA:7191
database_cross_reference: MA:0002444
database_cross_reference: OpenCyc:Mx4rvViCtpwpEbGdrcN5Y29ycA
database_cross_reference: TAO:0001127
definition: The sensory system subserving the sense of vision.
external_definition: The sensory system used for sight.[AAO]
editor note: This class was created automatically from a combination of ontologies
id: UBERON:0002104
has_alternative_id: UBERON:0007036
database_cross_reference: UMLS:C0587900
database_cross_reference: XAO:0003198
database_cross_reference: ZFA:0001127
has_exact_synonym: photosensory system
has_obo_namespace: uberon
has_exact_synonym: visual organ system
database_cross_reference: Visual system
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0587900
database_cross_reference: Visual System
spatially disjoint from: vestibulo-auditory system
imported from: oae.owl
imported from: uberon.owl
in_subset: uberon slim
in_subset: vertebrate core
database_cross_reference: FMAID 7191
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/281831001

vestibulo-auditory system
type: Class
subclass of: sensory system
database_cross_reference: AAO:0000631
database_cross_reference: FMA:78500
definition: Sensory system responsible for the perception of spatial orientation and auditory stimuli.
database_cross_reference: TAO:0001138
external_definition: The sensory system used for balance and hearing.[AAO]
id: UBERON:0002105
database_cross_reference: XAO:0003195
database_cross_reference: ZFA:0001138
has_exact_synonym: auditory organ system
has_related_synonym: auditory system
has_related_synonym: auditory/vestibular system
has_obo_namespace: uberon
has_exact_synonym: vestibuloauditory system
has_related_synonym: vestibuloauditory system
imported from: oae.owl
imported from: uberon.owl
in_subset: functional classification
in_subset: uberon slim
in_subset: vertebrate core

epiblast (generic)
type: Class
subclass of: embryonic structure
subclass of: Restriction
  on property: has_part
  some values from: epiblast cell
database_cross_reference: BTO:0004593
definition: In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA]
homology_notes: In pregastrula zebrafish embryos, the epiblast is an inverted cup of cells that sits on top of a large yolk cell. (...) In amniote embryos (mammals and birds), gastrulation initiates in an epithelial layer called the epiblast. Cells in the epiblast undergo an epithelial to mesenchymal transition (EMT), migrate through the primitive streak (PS), and incorporate in the middle (mesoderm) or outer (endoderm) layer. The presumptive definitive endoderm (DE) cells invade and displace an outer layer of extraembryonic tissue cells, the hypoblast in chick and the visceral endoderm (VE) in mouse, which form supporting structures such as the yolk sac.[uncertain][VHOG]
database_cross_reference: MAT:0000067
database_cross_reference: MIAA:0000067
editor note: MP says - tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper. In HOG, epiblast is part of primitive streak/blastpore, which is inconsistent with the MP definition of primitive streak as a ridge of the epiblast. Note that these terms, epiblast and hypoblast, are also used to describe layers of the avian embryonic blastoderm, but the layers so-named seem to be altogether different in these two kinds of vertebrate embryos(CVS). Consider obsoleting this as a grouping class
id: UBERON:0002532
database_cross_reference: VHOG:0000243
has_related_synonym: blastocyst
has_related_synonym: ectoblast
has_exact_synonym: epiblast
has_related_synonym: epiblastus
has_related_synonym: primitive ectoderm
has_obo_namespace: uberon
database_cross_reference: Epiblast
imported from: oae.owl
imported from: uberon.owl
in_subset: early development
in_subset: grouping class
in_subset: uberon slim
in_subset: vertebrate core

ectoderm-derived structure
type: Class
equivalent class: Class
  intersection of: anatomical structure
  intersection of: Restriction
    on property: develops_from
    some values from: ectoderm
subclass of: anatomical structure
subclass of: Restriction
  on property: develops_from
  some values from: ectoderm
definition: An anatomical structure that develops (entirely or partially) from the ectoderm.
comment: Grouping term for query purposes
id: UBERON:0004121
has_obo_namespace: uberon
imported from: oae.owl
imported from: uberon.owl
in_subset: grouping class

entire sense organ system
type: Class
subclass of: anatomical system
subclass of: Restriction
  on property: existence ends during
  some values from: fully formed stage
subclass of: Restriction
  on property: has_part
  some values from: Restriction
    on property: part_of
    some values from: nervous system
database_cross_reference: FMA:78499
definition: Sum of all sensory systems in an organism.
id: UBERON:0004456
external_ontology_notes: note the distinct between entire sensory system and individual system. this reconciles is_a and part_of distinctions between ssAOs
has_exact_synonym: sense organ system
has_obo_namespace: uberon
imported from: oae.owl
imported from: uberon.owl
in_subset: uberon slim

embryonic tissue
type: Class
equivalent class: Class
  intersection of: tissue
  intersection of: Restriction
    on property: part_of
    some values from: embryo
subclass of: tissue
subclass of: embryonic structure
subclass of: Restriction
  on property: part_of
  some values from: embryonic structure
subclass of: Restriction
  on property: part_of
  some values from: embryo
definition: A portion of tissue that is part of an embryo.
database_cross_reference: CALOHA:TS-2100
id: UBERON:0005291
has_related_synonym: developing tissue
has_exact_synonym: portion of embryonic tissue
has_obo_namespace: uberon
imported from: oae.owl
imported from: uberon.owl
in_subset: upper level

developing anatomical structure
type: Class
subclass of: material anatomical entity
subclass of: Restriction
  on property: capable_of
  some values from: developmental process
database_cross_reference: AEO:0000125
database_cross_reference: CALOHA:TS-2122
database_cross_reference: EHDAA2:0003125
database_cross_reference: FBbt:00007006
database_cross_reference: MIAA:0000019
id: UBERON:0005423
has_related_synonym: developing structure
has_related_synonym: developmental structure
has_related_synonym: developmental tissue
has_obo_namespace: uberon
imported from: oae.owl
imported from: uberon.owl

presumptive structure
type: Class
subclass of: developing anatomical structure
subclass of: Restriction
  on property: part_of
  some values from: embryo
database_cross_reference: AAO:0000479
database_cross_reference: TAO:0001116
id: UBERON:0006598
database_cross_reference: ZFA:0001116
has_exact_synonym: presumptive structures
has_obo_namespace: uberon
imported from: oae.owl
imported from: uberon.owl

presumptive ectoderm
type: Class
equivalent class: Class
  intersection of: presumptive structure
  intersection of: Restriction
    on property: part_of
    some values from: blastula
  intersection of: Restriction
    on property: has potential to develop into
    some values from: ectoderm
subclass of: presumptive structure
subclass of: Restriction
  on property: has potential to develop into
  some values from: ectoderm
subclass of: Restriction
  on property: part_of
  some values from: blastula
subclass of: Restriction
  on property: only in taxon
  some values from: Eumetazoa
database_cross_reference: AAO:0000470
database_cross_reference: EFO:0003466
definition: Presumptive structure of the blastula that will develop into ectoderm.
database_cross_reference: TAO:0001376
id: UBERON:0006601
database_cross_reference: XAO:0004132
database_cross_reference: ZFA:0001376
has_related_synonym: presumptive epidermis
has_obo_namespace: uberon
imported from: oae.owl
imported from: uberon.owl
in_subset: efo slim

anatomical surface
type: Class
subclass of: immaterial anatomical entity
database_cross_reference: AAO:0010270
database_cross_reference: BILA:0000010
database_cross_reference: CARO:0000010
database_cross_reference: EHDAA2:0003192
database_cross_reference: FMA:24137
database_cross_reference: ID:0000000
definition: Non-material anatomical entity of two dimensions, that is demarcated by anatomical lines or points on the external or internal surfaces of anatomical structures.
id: UBERON:0006984
database_cross_reference: UMLS:C1515977
database_cross_reference: ZFA:0005594
has_obo_namespace: uberon
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1515977
database_cross_reference: Anatomic Surface
imported from: oae.owl
imported from: uberon.owl
in_subset: upper level

cleaving embryo
type: Class
equivalent class: Class
  intersection of: multi-cellular organism
  intersection of: Restriction
    on property: existence starts with
    some values from: cleavage stage
  intersection of: Restriction
    on property: existence ends with
    some values from: cleavage stage
subclass of: embryo
subclass of: Restriction
  on property: existence starts with
  some values from: cleavage stage
subclass of: Restriction
  on property: existence ends with
  some values from: cleavage stage
database_cross_reference: BILA:0000058
definition: Organism at the cleavage stage.
id: UBERON:0007010
has_obo_namespace: uberon
imported from: oae.owl
imported from: uberon.owl

multicellular anatomical structure
type: Class
equivalent class: Class
  intersection of: anatomical structure
  intersection of: Restriction
    on property: has quality
    some values from: multicellular
subclass of: anatomical structure
subclass of: Restriction
  on property: has quality
  some values from: multicellular
subclass of: Restriction
  on property: has_part
  some values from: cell
definition: An anatomical structure that has more than one cell as a part.
database_cross_reference: CARO:0010000
database_cross_reference: FBbt:00100313
id: UBERON:0010000
has_exact_synonym: multicellular structure
has_obo_namespace: uberon
imported from: oae.owl
imported from: uberon.owl
in_subset: upper level

germ layer / neural crest
type: Class
subclass of: embryonic tissue
subclass of: Restriction
  on property: develops_from
  some values from: epiblast (generic)
id: UBERON:0010316
has_obo_namespace: uberon
imported from: oae.owl
imported from: uberon.owl

organ system subdivision
type: Class
subclass of: anatomical cluster
subclass of: Restriction
  on property: part_of
  some values from: anatomical system
definition: Anatomical structure, which consists of a specific set of the members of (predominantly) one organ or organ part subclass interconnected by zones of continuity or body substances; is demarcated from other subdivisions of the same organ system by one or more zones of continuity or anatomical lines; together with other subdivisions of the same organ system, it constitutes an organ system. Examples: rib cage, facial skeleton, portal system, central nervous system, upper respiratory tract, muscle group of back.
database_cross_reference: FBbt:00007330
database_cross_reference: FMA:67509
id: UBERON:0011216
has_obo_namespace: uberon
imported from: oae.owl
imported from: uberon.owl
in_subset: upper level
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/91690000

future central nervous system
type: Class
equivalent class: Class
  intersection of: developing anatomical structure
  intersection of: Restriction
    on property: has potential to develop into
    some values from: central nervous system
subclass of: developing anatomical structure
subclass of: Restriction
  on property: has potential to develop into
  some values from: central nervous system
subclass of: Restriction
  on property: develops_from
  some values from: ectoderm
subclass of: Restriction
  on property: part_of
  some values from: future nervous system
definition: Primordium that develops into the central nervous system
id: UBERON:0016879
has_alternative_id: UBERON:3000469
has_exact_synonym: future CNS
has_exact_synonym: presumptive central nervous system
has_obo_namespace: uberon
imported from: oae.owl
imported from: uberon.owl

future nervous system
type: Class
equivalent class: Class
  intersection of: developing anatomical structure
  intersection of: Restriction
    on property: has potential to develop into
    some values from: nervous system
subclass of: presumptive structure
subclass of: Restriction
  on property: part_of
  some values from: embryo
subclass of: Restriction
  on property: has potential to develop into
  some values from: nervous system
subclass of: Restriction
  on property: existence starts during or after
  some values from: organogenesis stage
database_cross_reference: AAO:0000477
definition: Primordium that develops into the nervous system
id: UBERON:0016880
has_alternative_id: UBERON:3000477
has_exact_synonym: presumptive nervous system
has_obo_namespace: uberon
imported from: oae.owl
imported from: uberon.owl

example to be eventually removed
type: NamedIndividual
type: curation status specification

metadata complete
type: NamedIndividual
type: curation status specification
definition: Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete.

organizational term
type: NamedIndividual
type: curation status specification
definition: term created to ease viewing/sort terms for development purpose, and will not be included in a release

ready for release
type: NamedIndividual
type: curation status specification
definition: Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking "ready_for_release" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release. Those classes deemed "ready_for_release" will also derived from a chain of ancestor classes that are also "ready_for_release."

metadata incomplete
type: NamedIndividual
type: curation status specification
definition: Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors.

uncurated
type: NamedIndividual
type: curation status specification
definition: Nothing done yet beyond assigning a unique class ID and proposing a preferred term.

pending final vetting
type: NamedIndividual
type: curation status specification
definition: All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the definition editor.

to be replaced with external ontology term
type: NamedIndividual
type: curation status specification
term editor: Alan Ruttenberg
definition: Terms with this status should eventually replaced with a term from another ontology.
definition source: group:OBI

requires discussion
type: NamedIndividual
type: curation status specification
definition: A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues.
term editor: Alan Ruttenberg
definition source: group:OBI

axiom holds for all times
type: NamedIndividual