\n",
" \n",
" | 0 | \n",
" unknown | \n",
" Although this development has been encouraging, supply issues in the United States and cardiovascular toxicity concerns limit the use of chloroquine. As an alternative, hydroxychloroquine, a compound that differs from chloroquine only by a single hydroxyl group, has garnered interest. Hydroxychloroq... | \n",
"
\n",
" \n",
" | 1 | \n",
" unknown | \n",
" Overall, 956,374 and 310,350 users of hydroxychloroquine and sulfasalazine, and 323,122 and 351,956 users of hydroxychloroquine-azithromycin and hydroxychloroquine-amoxicillin were included. No excess risk of SAEs was identified when 30-day hydroxychloroquine and sulfasalazine use were compared. SCC... | \n",
"
\n",
" \n",
" | 2 | \n",
" unknown | \n",
" Hydroxychloroquine (an analogue of chloroquine) has been demonstrated to have an anti-SARS-CoV activity in vitro [12] . Hydroxychloroquine clinical safety profile is better than that of chloroquine (during long-term use) and allows higher daily dose [13] and has fewer concerns about drug-drug intera... | \n",
"
\n",
" \n",
" | 3 | \n",
" unknown | \n",
" The PBPK models for chloroquine and hydroxychloroquine were developed using Simcyp simulator (version 18). The chloroquine compound file was provided by Simcyp Limited (a Certara company, Blades Enterprise Centre, Sheffield, UK) and the hydroxychloroquine compound file was self-built. Physical and c... | \n",
"
\n",
" \n",
" | 4 | \n",
" unknown | \n",
" [10], hydroxychloroquine [11] , and IFN-β-1a [12] as well as reported EC 50 values in vitro 125 (see Table 1 author/funder, who has granted medRxiv a license to display the preprint in perpetuity.... | \n",
"
\n",
" \n",
"