{ "graphs" : [ { "id" : "http://purl.obolibrary.org/obo/pato.json", "meta" : { "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000700", "val" : "http://purl.obolibrary.org/obo/PATO_0000001" }, { "pred" : "http://purl.org/dc/elements/1.1/description", "val" : "An ontology of phenotypic qualities (properties, attributes or characteristics)." }, { "pred" : "http://purl.org/dc/elements/1.1/title", "val" : "PATO - the Phenotype And Trait Ontology" }, { "pred" : "http://purl.org/dc/terms/license", "val" : "https://creativecommons.org/licenses/by/3.0/" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#default-namespace", "val" : "quality" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBOFormatVersion", "val" : "1.2" }, { "pred" : "http://www.w3.org/2002/07/owl#versionInfo", "val" : "2023-05-18" } ], "version" : "http://purl.obolibrary.org/obo/pato/releases/2023-05-18/pato.json" }, "nodes" : [ { "id" : "http://purl.obolibrary.org/obo/BFO_0000002", "lbl" : "continuant", "type" : "CLASS", "meta" : { "definition" : { "val" : "An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts." } } }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000003", "lbl" : "occurrent", "type" : "CLASS", "meta" : { "definition" : { "val" : "An entity that has temporal parts and that happens, unfolds or develops through time." } } }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000004", "lbl" : "independent continuant", "type" : "CLASS", "meta" : { "definition" : { "val" : "A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything." } } }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000006", "lbl" : "spatial region", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000015", "lbl" : "process", "type" : "CLASS", "meta" : { "definition" : { "val" : "An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t." } } }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000016", "lbl" : "disposition", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000017", "lbl" : "realizable entity", "type" : "CLASS", "meta" : { "definition" : { "val" : "A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances." } } }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000019", "lbl" : "quality", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000020", "lbl" : "specifically dependent continuant", "type" : "CLASS", "meta" : { "definition" : { "val" : "A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same." } } }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000023", "lbl" : "role", "type" : "CLASS", "meta" : { "definition" : { "val" : "A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts." } } }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000034", "lbl" : "function", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000040", "lbl" : "material entity", "type" : "CLASS", "meta" : { "definition" : { "val" : "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time." } } }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000050", "lbl" : "part_of", "type" : "PROPERTY", "meta" : { "definition" : { "val" : "a core relation that holds between a part and its whole" }, "subsets" : [ "http://purl.obolibrary.org/obo/valid_for_go_annotation_extension", "http://purl.obolibrary.org/obo/valid_for_go_gp2term", "http://purl.obolibrary.org/obo/valid_for_go_ontology", "http://purl.obolibrary.org/obo/valid_for_gocam" ], "xrefs" : [ { "val" : "BFO:0000050" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", "val" : "is part of" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000112", "val" : "my brain is part of my body (continuant parthood, two material entities)" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000112", "val" : "my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000112", "val" : "this day is part of this year (occurrent parthood)" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000116", "val" : "Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other." }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000116", "val" : "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000116", "val" : "Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.)\n\nA continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'." }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000118", "val" : "part_of" }, { "pred" : "http://purl.obolibrary.org/obo/RO_0001900", "val" : "http://purl.obolibrary.org/obo/RO_0001901" }, { "pred" : "http://purl.obolibrary.org/obo/RO_0040042", "val" : "http://purl.obolibrary.org/obo/BFO_0000002" }, { "pred" : "http://purl.obolibrary.org/obo/RO_0040042", "val" : "http://purl.obolibrary.org/obo/BFO_0000003" }, { "pred" : "http://purl.obolibrary.org/obo/RO_0040042", "val" : "http://purl.obolibrary.org/obo/BFO_0000004" }, { "pred" : "http://purl.obolibrary.org/obo/RO_0040042", "val" : "http://purl.obolibrary.org/obo/BFO_0000017" }, { "pred" : "http://purl.obolibrary.org/obo/RO_0040042", "val" : "http://purl.obolibrary.org/obo/BFO_0000019" }, { "pred" : "http://purl.obolibrary.org/obo/RO_0040042", "val" : "http://purl.obolibrary.org/obo/BFO_0000020" }, { "pred" : "http://purl.obolibrary.org/obo/RO_0040042", "val" : "http://purl.obolibrary.org/obo/BFO_0000031" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "external" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "quality" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "uberon" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand", "val" : "part_of" }, { "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso", "val" : "http://ontologydesignpatterns.org/wiki/Community:Parts_and_Collections" }, { "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso", "val" : "http://ontologydesignpatterns.org/wiki/Submissions:PartOf" }, { "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso", "val" : "http://www.obofoundry.org/ro/#OBO_REL:part_of" } ] } }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000051", "lbl" : "has_part", "type" : "PROPERTY", "meta" : { "definition" : { "val" : "a core relation that holds between a whole and its part" }, "subsets" : [ "http://purl.obolibrary.org/obo/valid_for_go_annotation_extension", "http://purl.obolibrary.org/obo/valid_for_go_ontology", "http://purl.obolibrary.org/obo/valid_for_gocam" ], "xrefs" : [ { "val" : "BFO:0000051" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", "val" : "has part" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000112", "val" : "my body has part my brain (continuant parthood, two material entities)" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000112", "val" : "my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity)" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000112", "val" : "this year has part this day (occurrent parthood)" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000116", "val" : "Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part." }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000116", "val" : "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000116", "val" : "Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.)\n\nA continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'." }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000118", "val" : "has_part" }, { "pred" : "http://purl.obolibrary.org/obo/RO_0001900", "val" : "http://purl.obolibrary.org/obo/RO_0001901" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "external" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "quality" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "uberon" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand", "val" : "has_part" } ] } }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000062", "lbl" : "preceded by", "type" : "PROPERTY", "meta" : { "definition" : { "val" : "x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." }, "subsets" : [ "http://purl.obolibrary.org/obo/ro/subsets#ro-eco" ], "xrefs" : [ { "val" : "BFO:0000062" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", "val" : "preceded by" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000116", "val" : "An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other." }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000118", "val" : "is preceded by" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000118", "val" : "preceded_by" }, { "pred" : "http://purl.org/dc/elements/1.1/source", "val" : "http://www.obofoundry.org/ro/#OBO_REL:preceded_by" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "external" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "uberon" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand", "val" : "preceded_by" } ] } }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000063", "lbl" : "precedes", "type" : "PROPERTY", "meta" : { "definition" : { "val" : "x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." }, "subsets" : [ "http://purl.obolibrary.org/obo/ro/subsets#ro-eco" ], "xrefs" : [ { "val" : "BFO:0000063" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", "val" : "precedes" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "external" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "uberon" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand", "val" : "precedes" } ] } }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000066", "lbl" : "occurs in", "type" : "PROPERTY", "meta" : { "definition" : { "val" : "b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t" }, "comments" : [ "Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant" ], "subsets" : [ "http://purl.obolibrary.org/obo/valid_for_go_annotation_extension", "http://purl.obolibrary.org/obo/valid_for_go_ontology", "http://purl.obolibrary.org/obo/valid_for_gocam" ], "xrefs" : [ { "val" : "BFO:0000066" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", "val" : "occurs in" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000118", "val" : "occurs_in" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000118", "val" : "unfolds in" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000118", "val" : "unfolds_in" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "external" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand", "val" : "occurs_in" }, { "pred" : "http://www.w3.org/2000/01/rdf-schema#isDefinedBy", "val" : "http://purl.obolibrary.org/obo/bfo.owl" } ] } }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000067", "lbl" : "contains process", "type" : "PROPERTY", "meta" : { "definition" : { "val" : "[copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t" }, "comments" : [ "Paraphrase of definition: a relation between an independent continuant and a process, in which the process takes place entirely within the independent continuant" ], "xrefs" : [ { "val" : "BFO:0000067" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", "val" : "site of" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "uberon" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand", "val" : "contains_process" }, { "pred" : "http://www.w3.org/2000/01/rdf-schema#isDefinedBy", "val" : "http://purl.obolibrary.org/obo/bfo.owl" } ] } }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000141", "lbl" : "immaterial entity", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/BSPO_0000096", "lbl" : "anterior to", "type" : "PROPERTY", "meta" : { "xrefs" : [ { "val" : "BSPO:0000096" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "uberon" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand", "val" : "anterior_to" } ] } }, { "id" : "http://purl.obolibrary.org/obo/BSPO_0000097", "lbl" : "distal to", "type" : "PROPERTY", "meta" : { "xrefs" : [ { "val" : "BSPO:0000097" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "uberon" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand", "val" : "distal_to" } ] } }, { "id" : "http://purl.obolibrary.org/obo/BSPO_0000098", "lbl" : "dorsal to", "type" : "PROPERTY", "meta" : { "xrefs" : [ { "val" : "BSPO:0000098" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "uberon" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand", "val" : "dorsal_to" } ] } }, { "id" : "http://purl.obolibrary.org/obo/BSPO_0000099", "lbl" : "posterior to", "type" : "PROPERTY", "meta" : { "xrefs" : [ { "val" : "BSPO:0000099" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "uberon" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand", "val" : "posterior_to" } ] } }, { "id" : "http://purl.obolibrary.org/obo/BSPO_0000100", "lbl" : "proximal to", "type" : "PROPERTY", "meta" : { "xrefs" : [ { "val" : "BSPO:0000100" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "uberon" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand", "val" : "proximal_to" } ] } }, { "id" : "http://purl.obolibrary.org/obo/BSPO_0000102", "lbl" : "ventral to", "type" : "PROPERTY", "meta" : { "xrefs" : [ { "val" : "BSPO:0000102" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "uberon" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand", "val" : "ventral_to" } ] } }, { "id" : "http://purl.obolibrary.org/obo/BSPO_0000107", "lbl" : "deep to", "type" : "PROPERTY", "meta" : { "xrefs" : [ { "val" : 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"http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "chebi_ontology" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000000", "lbl" : "cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane.", "xrefs" : [ "CARO:mah" ] }, "comments" : [ "The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one)." ], "subsets" : [ "http://purl.obolibrary.org/obo/ubprop#_upper_level" ], "xrefs" : [ { "val" : "CALOHA:TS-2035" }, { "val" : "FBbt:00007002" }, { "val" : "FMA:68646" }, { "val" : "GO:0005623" }, { "val" : "KUPO:0000002" }, { "val" : "MESH:D002477" }, { "val" : "VHOG:0001533" }, { "val" : "WBbt:0004017" }, { "val" : "XAO:0003012" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000003", "lbl" : "native cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cell that is found in a natural setting, which includes multicellular organism cells 'in vivo' (i.e. part of an organism), and unicellular organisms 'in environment' (i.e. part of a natural environment).", "xrefs" : [ "CARO:mah" ] }, "comments" : [ "To accommodate unicellular organisms better, 'cell in vivo' has been re-labeled 'native cell' to better represent its intended meaning - that is, that it is a cell in the context of a multicellular organism or in a natural environment. 'Native' is intended to contrast with 'in vitro', which refers to cells or other biological entities that have been intentionally placed in a controlled, non-natural setting for the purpose of study or manipulation. (MAH 1.12.12)." ], "subsets" : [ "http://purl.obolibrary.org/obo/ubprop#_upper_level" ], "synonyms" : [ { "pred" : "hasNarrowSynonym", "val" : "cell in vivo" } ], "xrefs" : [ { "val" : "CARO:0000013" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000005", "lbl" : "fibroblast neural crest derived", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any fibroblast that is deriived from the neural crest.", "xrefs" : [ "https://orcid.org/0000-0001-5208-3432" ] } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000006", "lbl" : "neuronal receptor cell", "type" : "CLASS", "meta" : { "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "neuronal receptor cell (sensu Animalia)" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000007", "lbl" : "early embryonic cell (metazoa)", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cell found in the embryo before the formation of all the gem layers is complete.", "xrefs" : [ "GOC:tfm" ] } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000008", "lbl" : "migratory cranial neural crest cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination.", "xrefs" : [ "ZFA:0007091", "https://orcid.org/0000-0001-5208-3432" ] } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000011", "lbl" : "migratory trunk neural crest cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination.", "xrefs" : [ "ZFA:0007095", "https://orcid.org/0000-0001-5208-3432" ] } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000014", "lbl" : "germ line stem cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A stem cell that is the precursor of gametes.", "xrefs" : [ "doi:10.1016/j.stem.2012.05.016" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "germline stem cell" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000021", "lbl" : "female germ cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "Female germ cell is a germ cell that supports female gamete production.", "xrefs" : [ "GOC:tfm", "PMID:11023867", "PMID:20454446" ] }, "xrefs" : [ { "val" : "MA:0000388" }, { "val" : "VHOG:0001530" }, { "val" : "ncithesaurus:Egg" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000022", "lbl" : "female germ line stem cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A stem cell that is the precursor of female gametes.", "xrefs" : [ "doi:10.1016/j.stem.2012.05.016" ] }, "xrefs" : [ { "val" : "FBbt:00004873" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000023", "lbl" : "oocyte", "type" : "CLASS", "meta" : { "definition" : { "val" : "A female germ cell that has entered meiosis.", "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] }, "synonyms" : [ { "pred" : "hasRelatedSynonym", "val" : "oogonium" } ], "xrefs" : [ { "val" : "BTO:0000964" }, { "val" : "CALOHA:TS-0711" }, { "val" : "FBbt:00004886" }, { "val" : "FMA:18644" }, { "val" : "MESH:D009865" }, { "val" : "WBbt:0006797" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000024", "lbl" : "oogonial cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes.", "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] }, "xrefs" : [ { "val" : "FMA:83673" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000025", "lbl" : "egg cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization.", "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "mature oocyte" }, { "pred" : "hasExactSynonym", "val" : "ovum" } ], "xrefs" : [ { "val" : "BTO:0000369" }, { "val" : "BTO:0003801" }, { "val" : "CALOHA:TS-2191" }, { "val" : "FBbt:00057012" }, { "val" : "FMA:67343" }, { "val" : "MA:0000388" }, { "val" : "MESH:D010063" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000027", "lbl" : "smooth muscle cell neural crest derived", "type" : "CLASS", "meta" : { "definition" : { "val" : "A smooth muscle cell derived from the neural crest.", "xrefs" : [ "https://orcid.org/0000-0001-5208-3432" ] } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000029", "lbl" : "neural crest derived neuron", "type" : "CLASS", "meta" : { "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "neuron neural crest derived" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000030", "lbl" : "glioblast", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CL_0000031", "lbl" : "neuroblast (sensu Vertebrata)", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cell that will develop into a neuron often after a migration phase.", "xrefs" : [ "GOC:NV", "http://en.wikipedia.org/wiki/Neuroblast" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "neuroblast" } ], "xrefs" : [ { "val" : "BTO:0000930" }, { "val" : "FMA:70563" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000034", "lbl" : "stem cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.", "xrefs" : [ "GOC:tfm", "MESH:D013234" ] }, "comments" : [ "This term applies to metazoan. For plant stem cells, consider using PO:0004011 ‘initial cell’ or its parent PO:0004010 ‘meristematic cell’." ], "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "animal stem cell" } ], "xrefs" : [ { "val" : "CALOHA:TS-2086" }, { "val" : "FMA:63368" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000035", "lbl" : "single fate stem cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A stem cell that self-renews as well as give rise to a single mature cell type.", "xrefs" : [ "GOC:tfm" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "unipotent stem cell" }, { "pred" : "hasExactSynonym", "val" : "unipotential stem cell" } ], "xrefs" : [ { "val" : "FMA:70569" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000036", "lbl" : "epithelial fate stem cell", "type" : "CLASS", "meta" : { "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "epithelial stem cell" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000037", "lbl" : "hematopoietic stem cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119.", "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:tfm", "PMID:19022770", "http://en.wikipedia.org/wiki/Hematopoietic_stem_cell" ] }, "comments" : [ "Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative." ], "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "HSC" }, { "pred" : "hasExactSynonym", "val" : "blood forming stem cell" }, { "pred" : "hasExactSynonym", "val" : "hemopoietic stem cell" }, { "pred" : "hasRelatedSynonym", "val" : "colony forming unit hematopoietic" } ], "xrefs" : [ { "val" : "BTO:0000725" }, { "val" : "CALOHA:TS-0448" }, { "val" : "FMA:70337" }, { "val" : "FMA:86475" }, { "val" : "MESH:D006412" }, { "val" : "VHOG:0001485" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000038", "lbl" : "erythroid progenitor cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A progenitor cell committed to the erythroid lineage.", "xrefs" : [ "GOC:add", "ISBN:0721601464" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim" ], "synonyms" : [ { "pred" : "hasRelatedSynonym", "val" : "BFU-E" }, { "pred" : "hasRelatedSynonym", "val" : "CFU-E" }, { "pred" : "hasRelatedSynonym", "val" : "blast forming unit erythroid" }, { "pred" : "hasRelatedSynonym", "val" : "burst forming unit erythroid" }, { "pred" : "hasRelatedSynonym", "val" : "colony forming unit erythroid" }, { "pred" : "hasRelatedSynonym", "val" : "erythroid stem cell" } ], "xrefs" : [ { "val" : "BTO:0004911" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000039", "lbl" : "germ line cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring.", "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] }, "comments" : [ "Originally this term had some plant germ line cell children." ], "subsets" : [ "http://purl.obolibrary.org/obo/ubprop#_upper_level" ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000040", "lbl" : "monoblast", "type" : "CLASS", "meta" : { "definition" : { "val" : "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus.", "xrefs" : [ "GOC:add", "PMID:1104740", "http://en.wikipedia.org/wiki/Monoblast", "http://www.copewithcytokines.de" ] }, "comments" : [ "Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid." ], "synonyms" : [ { "pred" : "hasRelatedSynonym", "val" : "CFU-M" }, { "pred" : "hasRelatedSynonym", "val" : "colony forming unit macrophage" }, { "pred" : "hasRelatedSynonym", "val" : "colony forming unit monocyte" }, { "pred" : "hasRelatedSynonym", "val" : "monocyte stem cell" } ], "xrefs" : [ { "val" : "CALOHA:TS-1195" }, { "val" : "FMA:83553" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000042", "lbl" : "neutrophilic myeloblast", "type" : "CLASS", "meta" : { "definition" : { "val" : "A myeloblast committed to the neutrophil lineage. This cell type is GATA-1 positive, C/EBPa-positive, AML-1-positive, c-myb-positive and has low expression of PU.1 transcription factor.", "xrefs" : [ "GOC:add", "ISBN:0721601464", "PMID:12560239", "PMID:15514007" ] }, "comments" : [ "These cells are CD11b-negative, CD15-negative, CD16-negative, CD35-negative, CD49d-positive, CD68-positive, lactotransferrin-negative, and fMLP receptor-negative. They are found in the Band 3 fraction." ], "synonyms" : [ { "pred" : "hasRelatedSynonym", "val" : "neutrophilic granuloblast" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000048", "lbl" : "multi fate stem cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A stem cell that can give rise to multiple lineages of cells.", "xrefs" : [ "GOC:add" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "multi-fate stem cell" }, { "pred" : "hasExactSynonym", "val" : "multifate stem cell" }, { "pred" : "hasExactSynonym", "val" : "multipotent cell" }, { "pred" : "hasExactSynonym", "val" : "multipotent stem cell" } ], "xrefs" : [ { "val" : "FMA:84789" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000049", "lbl" : "common myeloid progenitor", "type" : "CLASS", "meta" : { "definition" : { "val" : "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages.", "xrefs" : [ "GOC:add", "ISBN:0878932437", "MESH:D023461" ] }, "comments" : [ "This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059)." ], "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "CMP", "xrefs" : [ "ISBN:0878932437" ] }, { "pred" : "hasExactSynonym", "val" : "common myeloid precursor" }, { "pred" : "hasRelatedSynonym", "val" : "CFU-GEMM", "xrefs" : [ "ISBN:0878932437" ] }, { "pred" : "hasRelatedSynonym", "val" : "CFU-S", "xrefs" : [ "ISBN:0878932437" ] }, { "pred" : "hasRelatedSynonym", "val" : "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte", "xrefs" : [ "ISBN:0878932437" ] }, { "pred" : "hasRelatedSynonym", "val" : "multipotential myeloid stem cell", "xrefs" : [ "ISBN:0878932437" ] }, { "pred" : "hasRelatedSynonym", "val" : "myeloid stem cell", "xrefs" : [ "ISBN:0878932437" ] }, { "pred" : "hasRelatedSynonym", "val" : "pluripotent stem cell (bone marrow)", "xrefs" : [ "ISBN:0878932437" ] } ], "xrefs" : [ { "val" : "BTO:0004730" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000050", "lbl" : "megakaryocyte-erythroid progenitor cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A progenitor cell committed to the megakaryocyte and erythroid lineages.", "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:tfm", "MESH:D055015", "PMID:16647566", "http://en.wikipedia.org/wiki/Megakaryocyte-erythroid_progenitor_cell" ] }, "comments" : [ "MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2." ], "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "CFU-EM" }, { "pred" : "hasExactSynonym", "val" : "CFU-MegE" }, { "pred" : "hasExactSynonym", "val" : "MEP" }, { "pred" : "hasExactSynonym", "val" : "Meg/E progenitor" }, { "pred" : "hasExactSynonym", "val" : "colony forming unit erythroid megakaryocyte" }, { "pred" : "hasExactSynonym", "val" : "megakaryocyte/erythrocyte progenitor" }, { "pred" : "hasExactSynonym", "val" : "megakaryocyte/erythroid progenitor cell" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000051", "lbl" : "common lymphoid progenitor", "type" : "CLASS", "meta" : { "definition" : { "val" : "A oligopotent progenitor cell committed to the lymphoid lineage.", "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:tfm", "PMID:10407577", "PMID:16551251" ] }, "comments" : [ "CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative." ], "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "CLP" }, { "pred" : "hasExactSynonym", "val" : "common lymphocyte precursor" }, { "pred" : "hasExactSynonym", "val" : "common lymphocyte progenitor" }, { "pred" : "hasExactSynonym", "val" : "common lymphoid precursor" }, { "pred" : "hasRelatedSynonym", "val" : "ELP" }, { "pred" : "hasRelatedSynonym", "val" : "committed lymphopoietic stem cell" }, { "pred" : "hasRelatedSynonym", "val" : "early lymphocyte progenitor" }, { "pred" : "hasRelatedSynonym", "val" : "lymphoid stem cell" }, { "pred" : "hasRelatedSynonym", "val" : "lymphopoietic stem cell" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000052", "lbl" : "totipotent stem cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A stem cell from which all cells of the body can form.", "xrefs" : [ "GOC:add", "GOC:tfm" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "totipotential stem cell" } ], "xrefs" : [ { "val" : "FMA:84790" }, { "val" : "MESH:D039901" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000055", "lbl" : "non-terminally differentiated cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A precursor cell with a limited number of potential fates.", "xrefs" : [ "SANBI:mhl" ] }, "comments" : [ "define using PATO mulit-potent or oligopotent?" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "blast cell" } ], "xrefs" : [ { "val" : "BTO:0000125" }, { "val" : "FMA:84782" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000056", "lbl" : "myoblast", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair.", "xrefs" : [ "GOC:tfm", "MESH:D032446", "PMID:21849021" ] }, "xrefs" : [ { "val" : "BTO:0000222" }, { "val" : "CALOHA:TS-0650" }, { "val" : "FBbt:00005083" }, { "val" : "FMA:70335" }, { "val" : "VHOG:0001529" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000057", "lbl" : "fibroblast", "type" : "CLASS", "meta" : { "definition" : { "val" : "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped.", "xrefs" : [ "ISBN:0517223651", "MESH:D005347", "http://en.wikipedia.org/wiki/Fibroblast" ] }, "comments" : [ "These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative." ], "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "xrefs" : [ { "val" : "BTO:0000452" }, { "val" : "CALOHA:TS-0362" }, { "val" : "FMA:63877" }, { "val" : "VHOG:0001482" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000058", "lbl" : "chondroblast", "type" : "CLASS", "meta" : { "definition" : { "val" : "Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell.", "xrefs" : [ "GOC:tfm", "GO_REF:0000034", "ISBN:0618947256" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "chrondoplast" } ], "xrefs" : [ { "val" : "BTO:0003607" }, { "val" : "FMA:66783" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000064", "lbl" : "ciliated cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cell that has a filiform extrusion of the cell surface.", "xrefs" : [ "GOC:tfm" ] }, "xrefs" : [ { "val" : "VHOG:0001532" }, { "val" : "XAO:0000031" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000066", "lbl" : "epithelial cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina.", "xrefs" : [ "FB:ma", "GOC:tfm", "MESH:D004847" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "epitheliocyte" } ], "xrefs" : [ { "val" : "BTO:0000414" }, { "val" : "CALOHA:TS-2026" }, { "val" : "CARO:0000077" }, { "val" : "FBbt:00000124" }, { "val" : "FMA:66768" }, { "val" : "WBbt:0003672" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000067", "lbl" : "ciliated epithelial cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "An epithelial cell that has a cilia.", "xrefs" : [ "GOC:tfm" ] }, "xrefs" : [ { "val" : "FMA:70605" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000068", "lbl" : "duct epithelial cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "An epithelial cell that is part of a duct.", "xrefs" : [ "https://orcid.org/0000-0001-5208-3432" ] } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000069", "lbl" : "branched duct epithelial cell", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CL_0000071", "lbl" : "blood vessel endothelial cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "An endothelial cell that lines the vasculature.", "xrefs" : [ "GOC:tfm" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "cuboidal endothelial cell of vascular tree" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000075", "lbl" : "columnar/cuboidal epithelial cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.", "xrefs" : [ "GO:0002065", "https://orcid.org/0000-0001-5208-3432" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000076", "lbl" : "squamous epithelial cell", "type" : "CLASS", "meta" : { "xrefs" : [ { "val" : "CALOHA:TS-1249" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000077", "lbl" : "mesothelial cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A flattened epithelial cell of mesenchymal origin that lines the serous cavity.", "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "mesotheliocyte" } ], "xrefs" : [ { "val" : "FMA:66773" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000079", "lbl" : "stratified epithelial cell", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CL_0000080", "lbl" : "circulating cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cell which moves among different tissues of the body, via blood, lymph, or other medium.", "xrefs" : [ "GOC:add" ] } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000081", "lbl" : "blood cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cell found predominately in the blood.", "xrefs" : [ "GOC:add", "GOC:tfm" ] }, "xrefs" : [ { "val" : "FMA:62844" }, { "val" : "MESH:D001773" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000082", "lbl" : "epithelial cell of lung", "type" : "CLASS", "meta" : { "definition" : { "val" : "An epithelial cell of the lung.", "xrefs" : [ "https://orcid.org/0000-0001-5208-3432" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "lung epithelial cell" } ], "xrefs" : [ { "val" : "BTO:0004299" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000083", "lbl" : "epithelial cell of pancreas", "type" : "CLASS", "meta" : { "definition" : { "val" : "An epithelial cell of the pancreas.", "xrefs" : [ "GOC:tfm" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "pancreas epithelial cell" }, { "pred" : "hasExactSynonym", "val" : "pancreatic epithelial cell" } ], "xrefs" : [ { "val" : "BTO:0000028" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000084", "lbl" : "T cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.", "xrefs" : [ "GOC:add", "GOC:tfm", "ISBN:0781735149" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "T lymphocyte" }, { "pred" : "hasExactSynonym", "val" : "T-cell" }, { "pred" : "hasExactSynonym", "val" : "T-lymphocyte" }, { "pred" : "hasRelatedSynonym", "val" : "immature T cell" }, { "pred" : "hasRelatedSynonym", "val" : "mature T cell" } ], "xrefs" : [ { "val" : "BTO:0000782" }, { "val" : "CALOHA:TS-1001" }, { "val" : "FMA:62870" }, { "val" : "MESH:D013601" }, { "val" : "VHOG:0001479" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000092", "lbl" : "osteoclast", "type" : "CLASS", "meta" : { "definition" : { "val" : "A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive.", "xrefs" : [ "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149", "PMID:10428500", "PMID:15055519", "PMID:17380158" ] }, "comments" : [ "Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid." ], "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasRelatedSynonym", "val" : "chondroclast" } ], "xrefs" : [ { "val" : "BTO:0000968" }, { "val" : "CALOHA:TS-0721" }, { "val" : "FMA:66781" }, { "val" : "MESH:D010010" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000094", "lbl" : "granulocyte", "type" : "CLASS", "meta" : { "definition" : { "val" : "A leukocyte with abundant granules in the cytoplasm.", "xrefs" : [ "GOC:amm", "GOC:tfm", "MESH:D006098", "http://en.wikipedia.org/wiki/Granulocyte" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "granular leucocyte" }, { "pred" : "hasExactSynonym", "val" : "granular leukocyte" }, { "pred" : "hasExactSynonym", "val" : "polymorphonuclear leukocyte" } ], "xrefs" : [ { "val" : "BTO:0000539" }, { "val" : "BTO:0001026" }, { "val" : "CALOHA:TS-0422" }, { "val" : "FMA:62854" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000095", "lbl" : "neuron associated cell", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CL_0000098", "lbl" : "sensory epithelial cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells.", "xrefs" : [ "GOC:tfm", "ISBN:0517223651", "ISBN:0721662544" ] }, "comments" : [ "The term \"neuroepithelial cell\" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710)." ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "neuroepithelial cell" } ], "xrefs" : [ { "val" : "BTO:0004301" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000099", "lbl" : "interneuron", "type" : "CLASS", "meta" : { "definition" : { "val" : "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions.", "xrefs" : [ "GOC:tfm", "MESH:D007395" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "xrefs" : [ { "val" : "BTO:0003811" }, { "val" : "FBbt:00005125" }, { "val" : "FMA:67313" }, { "val" : "WBbt:0005113" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000100", "lbl" : "motor neuron", "type" : "CLASS", "meta" : { "definition" : { "val" : "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement.", "xrefs" : [ "MESH:D009046", "PMID:16875686" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "motoneuron" } ], "xrefs" : [ { "val" : "BTO:0000312" }, { "val" : "FBbt:00005123" }, { "val" : "FMA:83617" }, { "val" : "WBbt:0005409" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000101", "lbl" : "sensory neuron", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any neuron having a sensory function; an afferent neuron conveying sensory impulses.", "xrefs" : [ "ISBN:0721662544" ] }, "xrefs" : [ { "val" : "BTO:0001037" }, { "val" : "FBbt:00005124" }, { "val" : "FMA:84649" }, { "val" : "MESH:D011984" }, { "val" : "WBbt:0005759" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000103", "lbl" : "bipolar neuron", "type" : "CLASS", "meta" : { "definition" : { "val" : "A type of interneuron that has two neurites, usually an axon and a dendrite, extending from opposite poles of an ovoid cell body.", "xrefs" : [ "GOC:tfm", "ISBN:0444009442" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/cl#BDS_subset" ], "xrefs" : [ { "val" : "FMA:67282" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000104", "lbl" : "multipolar neuron", "type" : "CLASS", "meta" : { "definition" : { "val" : "A neuron with three or more neurites, usually an axon and multiple dendrites.", "xrefs" : [ "FMA:67287", "GOC:tfm" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/cl#BDS_subset" ], "xrefs" : [ { "val" : "FMA:67287" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000107", "lbl" : "autonomic neuron", "type" : "CLASS", "meta" : { "definition" : { "val" : "A neuron whose cell body is within an autonomic ganglion.", "xrefs" : [ "GOC:tfm" ] }, "xrefs" : [ { "val" : "FMA:80121" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000108", "lbl" : "cholinergic neuron", "type" : "CLASS", "meta" : { "definition" : { "val" : "A neuron that uses acetylcholine as a vesicular neurotransmitter.", "xrefs" : [ "GOC:tfm" ] }, "xrefs" : [ { "val" : "BTO:0004902" }, { "val" : "FBbt:00007173" }, { "val" : "FMA:84796" }, { "val" : "MESH:D059329" }, { "val" : "WBbt:0006840" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000114", "lbl" : "surface ectodermal cell", "type" : "CLASS", "meta" : { "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "cell of surface ectoderm" }, { "pred" : "hasExactSynonym", "val" : "surface ectoderm cell" } ], "xrefs" : [ { "val" : "FMA:72552" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000115", "lbl" : "endothelial cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm.", "xrefs" : [ "GOC:tfm", "MESH:D042783", "PMID:21275341", "http://en.wikipedia.org/wiki/Endothelial_cell", "https://sourceforge.net/tracker/?func=detail&atid=440764&aid=3364936&group_id=36855" ] }, "comments" : [ "From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard]." ], "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "endotheliocyte" } ], "xrefs" : [ { "val" : "BTO:0001176" }, { "val" : "CALOHA:TS-0278" }, { "val" : "FMA:66772" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000117", "lbl" : "CNS neuron (sensu Vertebrata)", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CL_0000122", "lbl" : "stellate neuron", "type" : "CLASS", "meta" : { "definition" : { "val" : "A neuron that has dendritic processes radiating from the cell body forming a star-like shape.", "xrefs" : [ "ISBN:9780123973481" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/cl#BDS_subset" ], "xrefs" : [ { "val" : "BTO:0002316" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000123", "lbl" : "neuron associated cell (sensu Vertebrata)", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CL_0000125", "lbl" : "glial cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons.", "xrefs" : [ "MESH:D009457" ] }, "comments" : [ "Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "neuroglial cell" }, { "pred" : "hasRelatedSynonym", "val" : "neuroglia" } ], "xrefs" : [ { "val" : "BTO:0002606" }, { "val" : "CALOHA:TS-0415" }, { "val" : "FBbt:00005144" }, { "val" : "FMA:54536" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000126", "lbl" : "macroglial cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together.", "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "macrogliocyte" } ], "xrefs" : [ { "val" : "BTO:0000771" }, { "val" : "CALOHA:TS-2027" }, { "val" : "FMA:54538" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000128", "lbl" : "oligodendrocyte", "type" : "CLASS", "meta" : { "definition" : { "val" : "A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system.", "xrefs" : [ "MESH:D009836", "http://en.wikipedia.org/wiki/Oligodendrocyte" ] }, "comments" : [ "Oligodendrocytes are reportedly MDP-positive and CD4-negative." ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "OLs", "xrefs" : [ "PMID:8734446" ] }, { "pred" : "hasRelatedSynonym", "val" : "oligodendroglia" } ], "xrefs" : [ { "val" : "BTO:0000962" }, { "val" : "CALOHA:TS-0709" }, { "val" : "FMA:54540" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000133", "lbl" : "neurectodermal cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "Ectoderm destined to be nervous tissue.", "xrefs" : [ "GOC:tfm", "ISBN:068340007X" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "neurectoderm cell" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000134", "lbl" : "mesenchymal stem cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs.", "xrefs" : [ "FB:ma", "GOC:dsd", "PMCID:PMC2613570", "PMID:10102814", "PMID:16923606", "PMID:17986482", "PMID:19960544", "http://en.wikipedia.org/wiki/Mesenchymal_stem_cell", "http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells" ] }, "comments" : [ "Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2." ], "synonyms" : [ { "pred" : "hasNarrowSynonym", "val" : "BMSC" }, { "pred" : "hasNarrowSynonym", "val" : "bone marrow stromal cells" }, { "pred" : "hasNarrowSynonym", "val" : "colony-forming unit-fibroblast" }, { "pred" : "hasNarrowSynonym", "val" : "marrow stromal cells", "xrefs" : [ "PMID:11378515" ] }, { "pred" : "hasRelatedSynonym", "val" : "CFU-F" }, { "pred" : "hasRelatedSynonym", "val" : "MSC", "xrefs" : [ "PMID:11378515" ] }, { "pred" : "hasRelatedSynonym", "val" : "mesenchymal precursor cell" }, { "synonymType" : "http://purl.obolibrary.org/obo/cl#PLURAL", "pred" : "hasRelatedSynonym", "val" : "mesenchymal progenitor cells", "xrefs" : [ "MESH:D044982" ] }, { "pred" : "hasRelatedSynonym", "val" : "mesenchymal stem cell" }, { "pred" : "hasRelatedSynonym", "val" : "mesenchymal stromal cell" }, { "synonymType" : "http://purl.obolibrary.org/obo/cl#PLURAL", "pred" : "hasRelatedSynonym", "val" : "mesenchymal stromal cells" }, { "synonymType" : "http://purl.obolibrary.org/obo/cl#PLURAL", "pred" : "hasRelatedSynonym", "val" : "stem cells, mesenchymal", "xrefs" : [ "MESH:D044982" ] } ], "xrefs" : [ { "val" : "BTO:0002625" }, { "val" : "BTO:0003298" }, { "val" : "FMA:70546" } ], "basicPropertyValues" : [ { "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso", "val" : "https://github.com/obophenotype/cell-ontology/issues/474" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000136", "lbl" : "fat cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides.", "xrefs" : [ "MESH:D017667" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "adipocyte" }, { "pred" : "hasExactSynonym", "val" : "adipose cell" } ], "xrefs" : [ { "val" : "BTO:0000443" }, { "val" : "CALOHA:TS-0012" }, { "val" : "FMA:63880" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000138", "lbl" : "chondrocyte", "type" : "CLASS", "meta" : { "definition" : { "val" : "Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell.", "xrefs" : [ "GO_REF:0000034", "MESH:D019902" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "cartilage cell" } ], "xrefs" : [ { "val" : "BTO:0000249" }, { "val" : "CALOHA:TS-0138" }, { "val" : "FMA:66782" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000145", "lbl" : "professional antigen presenting cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response.", "xrefs" : [ "GOC:add", "ISBN:0781735149" ] }, "comments" : [ "Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells." ], "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim" ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "APC" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000147", "lbl" : "pigment cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A pigment cell is a cell that contains pigment granules.", "xrefs" : [ "GOC:tfm" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "chromatocyte" }, { "pred" : "hasExactSynonym", "val" : "chromatophore" } ], "xrefs" : [ { "val" : "VHOG:0001678" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000148", "lbl" : "melanocyte", "type" : "CLASS", "meta" : { "definition" : { "val" : "A pigment cell derived from the neural crest. 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Club cells are dome-shaped with short microvilli but no cilia. They function to protect the bronchiolar epithelium. 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Its neuronal features resemble those of ordinary neurons concerning both structure and function. The production of a visible secretory material marks the neurosecretory neuron as a gland cell, and the fact that extractable cellular products act in the manner of hormones places it in the realm of endocrine elements. \n\nThe modern definition of neurosecretion has evolved to include the release of any neuronal secretory product from a neuron." ], "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasRelatedSynonym", "val" : "neurosecretory cell" }, { "pred" : "hasRelatedSynonym", "val" : "neurosecretory neuron" } ], "xrefs" : [ { "val" : "BTO:0002691" }, { "val" : "FBbt:00005130" }, { "val" : "FMA:83810" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000167", "lbl" : "peptide hormone secreting cell", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CL_0000168", "lbl" : "insulin secreting cell", "type" : "CLASS", "meta" : { "xrefs" : [ { "val" : "BTO:0000783" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000169", "lbl" : "type B pancreatic cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cell that secretes insulin and is located towards the center of the islets of Langerhans.", "xrefs" : [ "GOC:tfm", "ISBN:0517223651", "http://en.wikipedia.org/wiki/Pancreatic_b_cell" ] }, "comments" : [ "Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression." ], "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "beta cell", "xrefs" : [ "ZFA:0009102" ] }, { "pred" : "hasExactSynonym", "val" : "B-cell of pancreatic islet", "xrefs" : [ "FMA:70586" ] }, { "pred" : "hasExactSynonym", "val" : "beta cell of pancreatic islet", "xrefs" : [ "FMA:70586" ] }, { "pred" : "hasExactSynonym", "val" : "insulin-secreting cell", "xrefs" : [ "FMA:70586" ] }, { "pred" : "hasExactSynonym", "val" : "pancreatic B cell" }, { "pred" : "hasExactSynonym", "val" : "pancreatic B-cell", "xrefs" : [ "FMA:70586" ] }, { "pred" : "hasExactSynonym", "val" : "pancreatic beta cell", "xrefs" : [ "FMA:70586" ] }, { "pred" : "hasExactSynonym", "val" : "pancreatic islet core", "xrefs" : [ "MA:0002419" ] }, { "pred" : "hasExactSynonym", "val" : "type B enteroendocrine cell", "xrefs" : [ "FMA:70586" ] }, { "pred" : "hasRelatedSynonym", "val" : "beta cell islet", "xrefs" : [ "MA:0002419" ] } ], "xrefs" : [ { "val" : "BTO:0000783" }, { "val" : "EV:0200009" }, { "val" : "FMA:70586" }, { "val" : "MA:0002419" }, { "val" : "ncithesaurus:Beta_Cell" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000170", "lbl" : "glucagon secreting cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cell that secretes glucagon.", "xrefs" : [ "GOC:tfm" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "glucagon-secreting cell" } ], "xrefs" : [ { "val" : "FMA:84045" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000171", "lbl" : "pancreatic A cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon.", "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "alpha cell of islet of Langerhans" }, { "pred" : "hasExactSynonym", "val" : "pancreatic alpha cell" } ], "xrefs" : [ { "val" : "BTO:0000990" }, { "val" : "FMA:70585" }, { "val" : "MESH:D050416" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000172", "lbl" : "somatostatin secreting cell", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CL_0000173", "lbl" : "pancreatic D cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin.", "xrefs" : [ "FMA:0517223651", "GOC:tfm" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "D-cell of pancreatic islet" }, { "pred" : "hasExactSynonym", "val" : "delta cell of islet" }, { "pred" : "hasExactSynonym", "val" : "delta cell of pancreatic islet" }, { "pred" : "hasExactSynonym", "val" : "pancreatic D-cell" }, { "pred" : "hasExactSynonym", "val" : "pancreatic delta cell" }, { "pred" : "hasExactSynonym", "val" : "somatostatin-secreting pancreatic cell" } ], "xrefs" : [ { "val" : "BTO:0000803" }, { "val" : "FMA:70587" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000174", "lbl" : "steroid hormone secreting cell", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CL_0000182", "lbl" : "hepatocyte", "type" : "CLASS", "meta" : { "definition" : { "val" : "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. 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Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. 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These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.", "xrefs" : [ "GOC:tfm", "MESH:D017154" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "xrefs" : [ { "val" : "BTO:0002064" }, { "val" : "FMA:83624" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000502", "lbl" : "type D enteroendocrine cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. 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It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy.", "xrefs" : [ "GOC:tfm", "ISBN:0323052908" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "plasmidotrophoblast" }, { "pred" : "hasExactSynonym", "val" : "syncytial trophoblast" }, { "pred" : "hasExactSynonym", "val" : "syntrophoblast" } ], "xrefs" : [ { "val" : "FMA:83043" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000526", "lbl" : "afferent neuron", "type" : "CLASS", "meta" : { "definition" : { "val" : "A neuron which conveys sensory information centrally from the periphery.", "xrefs" : [ "GOC:tfm", "MESH:D009475" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "input neuron" } ], "xrefs" : [ { "val" : "FMA:87653" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000527", "lbl" : "efferent neuron", "type" : "CLASS", "meta" : { "definition" : { "val" : "A neuron which sends impulses peripherally to activate muscles or secretory cells.", "xrefs" : [ "MESH:D009476" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "output neuron" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000530", "lbl" : "primary neuron", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CL_0000531", "lbl" : "primary sensory neuron", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CL_0000540", "lbl" : "neuron", "type" : "CLASS", "meta" : { "definition" : { "val" : "The basic cellular unit of nervous tissue. 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This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers.", "xrefs" : [ "ISBN:0721601464", "MESH:A11.118.290.350.200", "PMID:1638021" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "rubriblast", "xrefs" : [ "ISBN:0721601464" ] }, { "pred" : "hasRelatedSynonym", "val" : "pronormoblast" } ], "xrefs" : [ { "val" : "FMA:83518" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000548", "lbl" : "animal cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A native cell that is part of some Metazoa." }, "subsets" : [ "http://purl.obolibrary.org/obo/ubprop#_upper_level" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "metazoan cell" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000549", "lbl" : "basophilic erythroblast", "type" : "CLASS", "meta" : { "definition" : { "val" : "A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers.", "xrefs" : [ "GOC:tfm", "ISBN:0721601464" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "basophilic normoblast", "xrefs" : [ "ISBN:0721601464" ] }, { "pred" : "hasExactSynonym", "val" : "early erythroblast", "xrefs" : [ "ISBN:0721601464" ] }, { "pred" : "hasExactSynonym", "val" : "early normoblast", "xrefs" : [ "ISBN:0721601464" ] }, { "pred" : "hasExactSynonym", "val" : "prorubricyte", "xrefs" : [ "ISBN:0721601464" ] } ], "xrefs" : [ { "val" : "FMA:83505" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000550", "lbl" : "polychromatophilic erythroblast", "type" : "CLASS", "meta" : { "definition" : { "val" : "A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers.", "xrefs" : [ "ISBN:0721601464" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "intermediate erythroblast", "xrefs" : [ "ISBN:0721601464" ] }, { "pred" : "hasExactSynonym", "val" : "intermediate normoblast", "xrefs" : [ "ISBN:0721601464" ] }, { "pred" : "hasExactSynonym", "val" : "polychromatic erythroblast", "xrefs" : [ "ISBN:0721601464" ] }, { "pred" : "hasExactSynonym", "val" : "polychromatic normoblast", "xrefs" : [ "ISBN:0721601464" ] }, { "pred" : "hasExactSynonym", "val" : "polychromatophilic normoblast", "xrefs" : [ "ISBN:0721601464" ] }, { "pred" : "hasExactSynonym", "val" : "rubricyte", "xrefs" : [ "ISBN:0721601464" ] } ], "xrefs" : [ { "val" : "FMA:83506" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000552", "lbl" : "orthochromatic erythroblast", "type" : "CLASS", "meta" : { "definition" : { "val" : "The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated.", "xrefs" : [ "ISBN:0721601464" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "acidophilic erythroblast", "xrefs" : [ "ISBN:0721601464" ] }, { "pred" : "hasExactSynonym", "val" : "eosinophilic erythroblast", "xrefs" : [ "ISBN:0721601464" ] }, { "pred" : "hasExactSynonym", "val" : "late erythoblast" }, { "pred" : "hasExactSynonym", "val" : "orthochromatic normoblast", "xrefs" : [ "ISBN:0721601464" ] }, { "pred" : "hasExactSynonym", "val" : "pyknotic eto enrythroblast", "xrefs" : [ "ISBN:0721601464" ] } ], "xrefs" : [ { "val" : "FMA:84646" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000553", "lbl" : "megakaryocyte progenitor cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative).", "xrefs" : [ "GOC:dsd", "GOC:tfm", "ISBN:0721601464" ] }, "comments" : [ "Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative." ], "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "CFU-Meg", "xrefs" : [ "PMID:11722431", "PMID:12482498" ] }, { "pred" : "hasExactSynonym", "val" : "Meg-CFC", "xrefs" : [ "PMCID:PMC1794060" ] }, { "pred" : "hasExactSynonym", "val" : "MkP", "xrefs" : [ "PMID:21116988" ] }, { "pred" : "hasExactSynonym", "val" : "colony-forming unit-megakaryocyte" }, { "pred" : "hasExactSynonym", "val" : "megacaryoblast" }, { "pred" : "hasExactSynonym", "val" : "megacaryocyte progenitor cell" }, { "pred" : "hasExactSynonym", "val" : "megakaryoblast" }, { "pred" : "hasExactSynonym", "val" : "megakaryocytic progenitor cell", "xrefs" : [ "PMID:12482498" ] }, { "pred" : "hasRelatedSynonym", "val" : "promegacaryocyte" }, { "pred" : "hasRelatedSynonym", "val" : "promegakaryocyte" } ], "xrefs" : [ { "val" : "BTO:0001164" }, { "val" : "CALOHA:TS-0610" }, { "val" : "FMA:84235" }, { "val" : "MESH:D055016" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000556", "lbl" : "megakaryocyte", "type" : "CLASS", "meta" : { "definition" : { "val" : "A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release.", "xrefs" : [ "ISBN:0721601464", "MESH:D008533", "PMID:31043076", "http://en.wikipedia.org/wiki/Megakaryocyte" ] }, "comments" : [ "Megakaryocytes are reportedly CD181-positive and CD182-positive." ], "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "megacaryocyte" }, { "pred" : "hasExactSynonym", "val" : "megalocaryocyte" }, { "pred" : "hasExactSynonym", "val" : "megalokaryocyte" } ], "xrefs" : [ { "val" : "BTO:0000843" }, { "val" : "CALOHA:TS-0611" }, { "val" : "FMA:83555" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000557", "lbl" : "granulocyte monocyte progenitor cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1.", "xrefs" : [ "GOC:amm", "GOC:dsd", "GOC:tfm", "GO_REF:0000031", "ISBN:0721601464", "MESH:D055014", "PMCID:PMC2213186", "PMCID:PMC548021", "PMID:16551251", "PMID:16647566", "http://en.wikipedia.org/wiki/CFU-GM", "http://www.copewithcytokines.de" ] }, "comments" : [ "Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative." ], "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "CFU-C , Colony forming unit in culture", "xrefs" : [ "http://www.copewithcytokines.de" ] }, { "pred" : "hasExactSynonym", "val" : "CFU-GM", "xrefs" : [ "ISBN:0721601464", "PMCID:PMC2213186", "PMCID:PMC548021" ] }, { "pred" : "hasExactSynonym", "val" : "GMP", "xrefs" : [ "ISBN:0721601464", "PMCID:PMC2213186", "PMCID:PMC548021" ] }, { "pred" : "hasExactSynonym", "val" : "colony forming unit granulocyte macrophage", "xrefs" : [ "ISBN:0721601464", "PMCID:PMC2213186", "PMCID:PMC548021" ] }, { "pred" : "hasExactSynonym", "val" : "granulocyte-macrophage progenitor", "xrefs" : [ "ISBN:0721601464", "PMCID:PMC2213186", "PMCID:PMC548021" ] }, { "pred" : "hasExactSynonym", "val" : "granulocyte/monocyte precursor" }, { "pred" : "hasExactSynonym", "val" : "granulocyte/monocyte progenitor" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000558", "lbl" : "reticulocyte", "type" : "CLASS", "meta" : { "definition" : { "val" : "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds.", "xrefs" : [ "GOC:add", "GOC:tfm", "PMID:15946868", "PMID:2037622" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim" ], "xrefs" : [ { "val" : "BTO:0001173" }, { "val" : "CALOHA:TS-0864" }, { "val" : "MESH:D012156" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000559", "lbl" : "promonocyte", "type" : "CLASS", "meta" : { "definition" : { "val" : "A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules.", "xrefs" : [ "GOC:tfm", "ISBN:0721601464" ] }, "comments" : [ "Morphology: Mononuclear cell, diameter 14-18 _M, fine azurophilic granules; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; Fetal: Liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid." ], "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "xrefs" : [ { "val" : "BTO:0004657" }, { "val" : "FMA:83551" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000562", "lbl" : "nucleate erythrocyte", "type" : "CLASS", "meta" : { "definition" : { "val" : "An erythrocyte having a nucleus.", "xrefs" : [ "GOC:add", "GOc:tfm" ] }, "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "RBC" }, { "pred" : "hasBroadSynonym", "val" : "red blood cell" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000564", "lbl" : "neutrophilic promyelocyte", "type" : "CLASS", "meta" : { "definition" : { "val" : "A promyelocyte committed to the neutrophil lineage. This cell type is GATA-1-positive, C/EBPa-positive, AML-1-positive, MPO-positive, has low expression of PU.1 transcription factor and lacks lactotransferrin expression.", "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:tfm", "ISBN:0721601464", "PMID:12560239", "PMID:15514007" ] }, "comments" : [ "These cells are CD11b-negative, CD15-positive, CD16-negative, CD49d-positive, CD68-positive, CD35-negative, and fMLP receptor-negative. They are found in the Band 3 fraction." ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "neutrophilic premyelocyte" }, { "pred" : "hasExactSynonym", "val" : "neutrophilic progranulocyte" } ], "xrefs" : [ { "val" : "FMA:84196" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000566", "lbl" : "angioblastic mesenchymal cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A mesenchymal stem cell capable of developing into blood vessel endothelium.", "xrefs" : [ "GOC:dsd", "GOC:tfm", "PMID:12768659" ] }, "comments" : [ "These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive." ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "angioblast" }, { "pred" : "hasExactSynonym", "val" : "chondroplast" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000569", "lbl" : "cardiac mesenchymal cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A mesenchymal cell found in the developing heart and that develops into some part of the heart. These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field.", "xrefs" : [ "PMID:18816864" ] } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000573", "lbl" : "retinal cone cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision.", "xrefs" : [ "MESH:D017949" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "xrefs" : [ { "val" : "BTO:0001036" }, { "val" : "CALOHA:TS-0866" }, { "val" : "FMA:67748" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000575", "lbl" : "corneal epithelial cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "An epithelial cell of the cornea.", "xrefs" : [ "GOC:tfm" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "epithelial cell of cornea", "xrefs" : [ "FMA:70551" ] } ], "xrefs" : [ { "val" : "BTO:0004298" }, { "val" : "CALOHA:TS-0173" }, { "val" : "FMA:70551" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000576", "lbl" : "monocyte", "type" : "CLASS", "meta" : { "definition" : { "val" : "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells.", "xrefs" : [ "GO_REF:0000031", "MESH:D009000" ] }, "comments" : [ "Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid." ], "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "xrefs" : [ { "val" : "BTO:0000876" }, { "val" : "CALOHA:TS-0638" }, { "val" : "FMA:62864" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000586", "lbl" : "germ cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "The reproductive cell in multicellular organisms.", "xrefs" : [ "MESH:D005854" ] }, "xrefs" : [ { "val" : "BTO:0000535" }, { "val" : "VHOG:0001534" }, { "val" : "WBbt:0006796" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000593", "lbl" : "androgen secreting cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A steroid hormone secreting cell that secretes androgen.", "xrefs" : [ "GOC:tfm" ] } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000595", "lbl" : "enucleate erythrocyte", "type" : "CLASS", "meta" : { "definition" : { "val" : "An erythrocyte lacking a nucleus.", "xrefs" : [ "GOC:add", "GOC:tfm" ] }, "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "RBC" }, { "pred" : "hasBroadSynonym", "val" : "red blood cell" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000598", "lbl" : "pyramidal neuron", "type" : "CLASS", "meta" : { "definition" : { "val" : "Pyramidal neurons have a pyramid-shaped soma with a single axon, a large apical dendrite and multiple basal dendrites. The apex and an apical dendrite typically point toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their region. Pyramidal neurons are found in the cerebral cortex, the hippocampus, and the amygdala.", "xrefs" : [ "GOC:tfm", "MESH:D017966" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/cl#BDS_subset" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "projection neuron" }, { "pred" : "hasExactSynonym", "val" : "pyramidal cell" }, { "pred" : "hasExactSynonym", "val" : "pyramidal neuron" } ], "xrefs" : [ { "val" : "BTO:0003102" }, { "val" : "FMA:67310" }, { "val" : "FMA:86775" }, { "val" : "NIFSTD:sao862606388" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000604", "lbl" : "retinal rod cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision.", "xrefs" : [ "MESH:D017948" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "xrefs" : [ { "val" : "BTO:0001024" }, { "val" : "CALOHA:TS-0870" }, { "val" : "FMA:67747" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000622", "lbl" : "acinar cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus).", "xrefs" : [ "GOC:tfm", "http://www.copewithcytokines.de" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "acinic cell" }, { "pred" : "hasExactSynonym", "val" : "acinous cell" } ], "xrefs" : [ { "val" : "FMA:83625" }, { "val" : 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{ "val" : "A mature sexual reproductive cell of the female germline.", "xrefs" : [ "GOC:tfm" ] } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000679", "lbl" : "glutamatergic neuron", "type" : "CLASS", "meta" : { "definition" : { "val" : "A neuron that is capable of some neurotansmission by glutamate secretion." }, "xrefs" : [ { "val" : "FBbt:00100291" }, { "val" : "WBbt:0006829" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000680", "lbl" : "muscle precursor cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A non-terminally differentiated cell that is capable of developing into a muscle cell.", "xrefs" : [ "GOC:add" ] } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000691", "lbl" : "stellate interneuron", "type" : "CLASS", "meta" : { "subsets" : [ "http://purl.obolibrary.org/obo/cl#BDS_subset" ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000693", "lbl" : "neurogliaform cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "An interneuron that has spider-like appearance with a small round soma, a large number (7-10) of short, smooth, or slightly beaded primary dendrites that give rise to only a few secondary branches, and a branched axon that establishes a dense axonal mesh with thin shafts.", "xrefs" : [ "JB:jb", "PMID:17122314" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/cl#BDS_subset" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "NGF cell", "xrefs" : [ "PMID:18568015" ] }, { "pred" : "hasExactSynonym", "val" : "neuroglioform cell", "xrefs" : [ "PMID:3235828" ] }, { "pred" : "hasExactSynonym", "val" : "spiderweb cell" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000696", "lbl" : "PP cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cell that stores and secretes pancreatic polypeptide hormone.", "xrefs" : [ "GOC:tfm", "JB:jb", "PMID:15153415" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "type F enteroendocrine cell" } ], "xrefs" : [ { "val" : "FMA:62938" }, { "val" : 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"CLASS", "meta" : { "definition" : { "val" : "Muscle cell which has as its direct parts myofilaments organized into sarcomeres.", "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] }, "xrefs" : [ { "val" : "BTO:0002916" }, { "val" : "CALOHA:TS-2157" }, { "val" : "FMA:86936" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000738", "lbl" : "leukocyte", "type" : "CLASS", "meta" : { "definition" : { "val" : "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.", "xrefs" : [ "GOC:add", "GOC:tfm", "ISBN:978-0-323-05290-0" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "leucocyte" }, { "pred" : "hasExactSynonym", "val" : "white blood cell" }, { "pred" : "hasRelatedSynonym", "val" : "immune cell" } ], "xrefs" : [ { "val" : "BTO:0000751" }, { "val" : "CALOHA:TS-0549" }, { "val" : "FMA:62852" }, { "val" : "MESH:D007962" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000740", "lbl" : "retinal ganglion cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve.", "xrefs" : [ "GOC:dph" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "RGC" }, { "pred" : "hasExactSynonym", "val" : "gangliocyte" }, { "pred" : "hasExactSynonym", "val" : "ganglion cell of retina" } ], "xrefs" : [ { "val" : "BTO:0001800" }, { "val" : "FMA:67765" }, { "val" : "MESH:D012165" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000746", "lbl" : "cardiac muscle cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei.", "xrefs" : [ "GOC:mtg_cardiacconduct_nov11", "GOC:tfm", "ISBN:0323052908", "PMID:22426062", "PMID:4711263" ] }, "comments" : [ "This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods. The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein). According to these refs, the cells participating in heart contraction in all cases are transversely striated. Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction." ], "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "cardiocyte" }, { "pred" : "hasExactSynonym", "val" : "cardiac muscle fiber", "xrefs" : [ "GO:0048739" ] }, { "pred" : "hasExactSynonym", "val" : "cardiac myocyte" }, { "pred" : "hasExactSynonym", "val" : "cardiomyocyte" }, { "pred" : "hasExactSynonym", "val" : "heart muscle cell" } ], "xrefs" : [ { "val" : "BTO:0001539" }, { "val" : "CALOHA:TS-0115" }, { "val" : "FMA:14067" }, { "val" : "MESH:D032383" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "FMA:83808" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000748", "lbl" : "retinal bipolar neuron", "type" : "CLASS", "meta" : { "definition" : { "val" : "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer.", "xrefs" : [ "PMID:14689473" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000752", "lbl" : "cone retinal bipolar cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A bipolar neuron found in the retina and having connections with cone photoreceptor cells and neurons in the inner plexiform layer.", "xrefs" : [ "PMID:14689473" ] } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000763", "lbl" : "myeloid cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage.", "xrefs" : [ "GOC:add" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "xrefs" : [ { "val" : "BTO:0001441" }, { "val" : "CALOHA:TS-0647" }, { "val" : "MESH:D022423" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000764", "lbl" : "erythroid lineage cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A immature or mature cell in the lineage leading to and including erythrocytes.", "xrefs" : [ "GOC:add", "GOC:tfm" ] }, "comments" : [ "Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes." ], "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "erythropoietic cell" } ], "xrefs" : [ { "val" : "CALOHA:TS-0290" }, { "val" : "FMA:62845" }, { "val" : "FMA:83516" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000765", "lbl" : "erythroblast", "type" : "CLASS", "meta" : { "definition" : { "val" : "A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers.", "xrefs" : [ "GOC:add", "ISBN:0721601464", "PMID:18174176" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "normoblast" } ], "xrefs" : [ { "val" : "BTO:0001571" }, { "val" : "CALOHA:TS-0289" }, { "val" : "FMA:83504" }, { "val" : "MESH:D004900" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000766", "lbl" : "myeloid leukocyte", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cell of the monocyte, granulocyte, or mast cell lineage.", "xrefs" : [ "GOC:add" ] } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000775", "lbl" : "neutrophil", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.", "xrefs" : [ "GOC:add", "GOC:amm", "GOC:tfm", "ISBN:0721601464" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "PMN" }, { "pred" : "hasBroadSynonym", "val" : "poly" }, { "pred" : "hasBroadSynonym", "val" : "polymorphonuclear leucocyte" }, { "pred" : "hasBroadSynonym", "val" : "polymorphonuclear leukocyte" }, { "pred" : "hasBroadSynonym", "val" : "polymorphonuclear neutrophil" }, { "pred" : "hasBroadSynonym", "val" : "polynuclear neutrophilic leucocyte" }, { "pred" : "hasBroadSynonym", "val" : "polynuclear neutrophilic leukocyte" }, { "pred" : "hasExactSynonym", "val" : "neutrocyte" }, { "pred" : "hasExactSynonym", "val" : "neutrophil leucocyte" }, { "pred" : "hasExactSynonym", "val" : "neutrophil leukocyte" }, { "pred" : "hasExactSynonym", "val" : "neutrophilic leucocyte" }, { "pred" : "hasExactSynonym", "val" : "neutrophilic leukocyte" } ], "xrefs" : [ { "val" : "BTO:0000130" }, { "val" : "CALOHA:TS-0688" }, { "val" : "FMA:62860" }, { "val" : "MESH:D009504" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000776", "lbl" : "immature neutrophil", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any of the immature forms of a neutrophil in which neutrophilic specific granules are present but other phenotypic features of the mature form may be lacking.", "xrefs" : [ "GOC:add", "ISBN:0721601464" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "immatuer neutrophilic leukocyte" }, { "pred" : "hasExactSynonym", "val" : "immature neutrocyte" }, { "pred" : "hasExactSynonym", "val" : "immature neutrophil leucocyte" }, { "pred" : "hasExactSynonym", "val" : "immature neutrophil leukocyte" }, { "pred" : "hasExactSynonym", "val" : "immature neutrophilic leucocyte" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000778", "lbl" : "mononuclear osteoclast", "type" : "CLASS", "meta" : { "definition" : { "val" : "A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts.", "xrefs" : [ "GOC:add", "GOC:tfm", "PMID:12713016", "PMID:15055519", "PMID:17380158", "PMID:9415452" ] }, "comments" : [ "Morphology: mononuclear, highly vesicular." ], "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "basicPropertyValues" : [ { "pred" : 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"PMID:10449155", "PMID:17332250", "PMID:9521319" ] }, "comments" : [ "These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. 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They reside in the bone marrow.", "xrefs" : [ "GOC:add", "ISBN:0721601464", "http://en.wikipedia.org/wiki/Myeloblast", "http://www.cap.org" ] }, "xrefs" : [ { "val" : "BTO:0000187" }, { "val" : "FMA:83524" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000836", "lbl" : "promyelocyte", "type" : "CLASS", "meta" : { "definition" : { "val" : "A precursor in the granulocytic series, being a cell intermediate in development between a myeloblast and myelocyte, that has distinct nucleoli, a nuclear-to-cytoplasmic ratio of 5:1 to 3:1, and containing a few primary cytoplasmic granules. Markers for this cell are fucosyltransferase FUT4-positive, CD33-positive, integrin alpha-M-negative, low affinity immunoglobulin gamma Fc region receptor III-negative, and CD24-negative.", "xrefs" : [ "GOC:add", "GOC:amm", "GOC:tfm", "ISBN:0721601464", "http://www.cap.org" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "xrefs" : [ { "val" : "CALOHA:TS-0825" }, { "val" : "FMA:83530" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000837", "lbl" : "hematopoietic multipotent progenitor cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans.", "xrefs" : [ "GOC:add", "GOC:tfm", "PMID:19022770" ] }, "comments" : [ "Markers differ between mouse and human." ], "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "MPP" }, { "pred" : "hasExactSynonym", "val" : "hemopoietic progenitor cell" } ], "xrefs" : [ { "val" : "BTO:0000725" }, { "val" : "CALOHA:TS-0448" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000838", "lbl" : "lymphoid lineage restricted progenitor cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A progenitor cell restricted to the lymphoid lineage.", "xrefs" : [ "GOC:add", "GOC:tfm" ] }, "comments" : [ "Note that this is a class of cell types, not an identified single cell type." ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "lymphoid progenitor cell" } ], "xrefs" : [ { "val" : "BTO:0004731" }, { "val" : "CALOHA:TS-2025" }, { "val" : "FMA:70338" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000839", "lbl" : "myeloid lineage restricted progenitor cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A progenitor cell restricted to the myeloid lineage.", "xrefs" : [ "GOC:add", "GOC:tfm", "PMID:19022770" ] }, "comments" : [ "Note that this is a class of cell types, not an identified single cell type." ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "myeloid progenitor cell" } ], "xrefs" : [ { "val" : "BTO:0004730" }, { "val" : "CALOHA:TS-2099" }, { "val" : "FMA:70339" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000842", "lbl" : "mononuclear cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A leukocyte with a single non-segmented nucleus in the mature form.", "xrefs" : [ "GOC:add" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "mononuclear leukocyte" }, { "pred" : "hasNarrowSynonym", "val" : "peripheral blood mononuclear cell" } ], "xrefs" : [ { "val" : "BTO:0000878" }, { "val" : "CALOHA:TS-0768" }, { "val" : "FMA:86713" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000850", "lbl" : "serotonergic neuron", "type" : "CLASS", "meta" : { "definition" : { "val" : "A neuron that releases serotonin as a neurotransmitter.", "xrefs" : [ "SANBI:mhl" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "5-HT neuron" }, { "pred" : "hasExactSynonym", "val" : "5-hydroxytryptamine neuron" }, { "pred" : "hasRelatedSynonym", "val" : "serotinergic neuron" } ], "xrefs" : [ { "val" : "FBbt:00005133" }, { "val" : "MESH:D059326" }, { "val" : "WBbt:0006837" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000864", "lbl" : "tissue-resident macrophage", "type" : "CLASS", "meta" : { "definition" : { "val" : "A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.", "xrefs" : [ "GOC:ana", "GO_REF:0000031", "PMID:19770654" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "fixed macrophage" }, { "pred" : "hasExactSynonym", "val" : "resting histiocyte" } ], "xrefs" : [ { "val" : "FMA:84642" }, { "val" : "FMA:84644" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000878", "lbl" : "central nervous system macrophage", "type" : "CLASS", "meta" : { "definition" : { "val" : "A tissue-resident macrophage found in the central nervous system.", "xrefs" : [ "GO_REF:0000031", "PMID:16322748" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "CNS macrophage" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000889", "lbl" : "myeloid suppressor cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "An immature myeloid leukocyte of heterogeneous phenotype found particularly in cancer and sepsis patients that is capable of suppressing activity of T cells in ex vivo assays. This cell type is CD45-positive, CD11b-positive.", "xrefs" : [ "GOC:add", "GOC:ana", "GO_REF:0000031", "PMID:16168663", "PMID:17016554", "PMID:17016559" ] }, "comments" : [ "Markers: Mouse: CD11b+GR1+CD31+; Human: CD34+ CD33+CD15-CD13+. (According to some reports in humans these cells are iNOS+ARG1+IL13+IFNg+); location: In cancerous tissue; in the blood and lymphoid organs in sepsis." ], "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim" ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000988", "lbl" : "hematopoietic cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cell of a hematopoietic lineage.", "xrefs" : [ "GOC:add", "GO_REF:0000031" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "haematopoietic cell" }, { "pred" : "hasExactSynonym", "val" : "haemopoietic cell" }, { "pred" : "hasExactSynonym", "val" : "hemopoietic cell" } ], "xrefs" : [ { "val" : "BTO:0000574" }, { "val" : "CALOHA:TS-2017" }, { "val" : "FMA:70366" }, { "val" : "FMA:83598" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000990", "lbl" : "conventional dendritic cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "Conventional dendritic cell is a dendritic cell that is CD11c-high.", "xrefs" : [ "GOC:amm", "GO_REF:0000031", "PMID:17850486" ] }, "comments" : [ "Originally described in the dendritic cell ontology (DC_CL:0000003)(PMID:19243617) These cells are also CD20-negative, MHCII-positive." ], "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "interdigitating cell" }, { "pred" : "hasBroadSynonym", "val" : "veiled cell" }, { "pred" : "hasExactSynonym", "val" : "DC1" }, { "pred" : "hasExactSynonym", "val" : "cDC" }, { "pred" : "hasExactSynonym", "val" : "dendritic reticular cell" }, { "pred" : "hasExactSynonym", "val" : "type 1 DC" } ], "xrefs" : [ { "val" : "FMA:84191" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000995", "lbl" : "CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor", "type" : "CLASS", "meta" : { "comments" : [ "Originally described in the dendritic cell ontology (DC_CL:1100000)(PMID:19243617)." ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "CD71-positive common myeloid precursor OR CD7-negative lymphoid precursor OR CD7-positive lymphoid" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001008", "lbl" : "Kit and Sca1-positive hematopoietic stem cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative.", "xrefs" : [ "GOC:add", "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:17952047", "PMID:19022770" ] }, "comments" : [ "Cell markers are associated with mouse hematopoietic stem cell. Originally described in the dendritic cell ontology (DC_CL:0000043)(PMID:19243617)." ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "LSK stem cell" }, { "pred" : "hasExactSynonym", "val" : "Sca1-positive hematopoietic stem cell" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001012", "lbl" : "CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor", "type" : "CLASS", "meta" : { "comments" : [ "Originally described in the dendritic cell ontology (DC_CL:1110000)(PMID:19243617)." ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001019", "lbl" : "CD115-positive monocyte OR common dendritic progenitor", "type" : "CLASS", "meta" : { "comments" : [ "Originally described in the dendritic cell ontology (DC_CL:1111000)(PMID:19243617)." ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001021", "lbl" : "CD34-positive, CD38-positive common lymphoid progenitor", "type" : "CLASS", "meta" : { "definition" : { "val" : "A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive.", "xrefs" : [ "GOC:add", "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMCID:PMC2346585", "PMID:19022770" ] }, "comments" : [ "These markers are associated with human common lymphoid progenitors. Originally described in the dendritic cell ontology (DC_CL:0000032)(PMID:19243617)." ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "CD10-positive common lymphocyte precursor" }, { "pred" : "hasExactSynonym", "val" : "CD10-positive common lymphocyte progenitor" }, { "pred" : "hasExactSynonym", "val" : "CD10-positive common lymphoid precursor" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001022", "lbl" : "CD115-positive monocyte", "type" : "CLASS", "meta" : { "definition" : { "val" : "CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive.", "xrefs" : [ "GOC:add", "GOC:amm", "GO_REF:0000031", "PMID:17952047" ] }, "comments" : [ "These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000033)(PMID:19243617)." ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001024", "lbl" : "CD34-positive, CD38-negative hematopoietic stem cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive.", "xrefs" : [ "GOC:add", "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:10430905", "PMID:11750107", "PMID:16551251", "PMID:20024907", "PMID:9389721" ] }, "comments" : [ "Cell markers are associated with human hematopoietic stem cells. Originally described in the dendritic cell ontology (DC_CL:0000035)(PMID:19243617)." ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "CD133-positive hematopoietic stem cell", "xrefs" : [ "PMID:16140871" ] } ], "xrefs" : [ { "val" : "CALOHA:TS-0448" }, { "val" : "FMA:86475" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001026", "lbl" : "CD34-positive, CD38-positive common myeloid progenitor", "type" : "CLASS", "meta" : { "definition" : { "val" : "A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative.", "xrefs" : [ "GOC:add", "GOC:amm", "GO_REF:0000031", "PMCID:PMC2626675", "PMID:16551251" ] }, "comments" : [ "Markers are associated with human cell type. Originally described in the dendritic cell ontology (DC_CL:0000038)(PMID:19243617)." ], "synonyms" : [ { "pred" : "hasNarrowSynonym", "val" : "CD71-positive common myeloid precursor" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001027", "lbl" : "CD7-negative lymphoid progenitor cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative.", "xrefs" : [ "GOC:amm", "GO_REF:0000031", "PMID:16551251" ] }, "comments" : [ "These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000039)(PMID:19243617)." ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "CD7-negative lymphoid precursor" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001028", "lbl" : "CD7-positive lymphoid progenitor cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative.", "xrefs" : [ "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:16551251", "PMID:19491395" ] }, "comments" : [ "These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000040)(PMID:19243617)." ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "CD7-positive lymphoid precursor" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001029", "lbl" : "common dendritic progenitor", "type" : "CLASS", "meta" : { "definition" : { "val" : "Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers.", "xrefs" : [ "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:16551251", "PMID:17922016", "PMID:19286519" ] }, "comments" : [ "Surface markers are for mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000041) CDP are reportedly CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD11c-positive, CD14-negative, CD19-negative, CD20-negative, CD56-negative, B220-negative, Ly6g-negative, MHCII-positive, and Ter119-negative. (PMID:19243617)." ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "CDP", "xrefs" : [ "PMID:21219184" ] }, { "pred" : "hasExactSynonym", "val" : "common dendritic precursor" }, { "pred" : "hasExactSynonym", "val" : "pro-DCs", "xrefs" : [ "PMID:21219184" ] } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001035", "lbl" : "bone cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A connective tissue cell found in bone.", "xrefs" : [ "GOC:add", "GO_REF:0000034" ] }, "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0001-9990-8331" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2011-11-16T04:28:16Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001054", "lbl" : "CD14-positive monocyte", "type" : "CLASS", "meta" : { "definition" : { "val" : "A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20.", "xrefs" : [ "GOC:add", "PMID:22343568" ] }, "comments" : [ "This cell type is compatible with the HIPC Lyoplate markers for 'monocyte'. Note that while CD14 is considered a reliable marker for human monocytes, it is only expressed on approximately 85% of mouse monocytes." ], "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasNarrowSynonym", "val" : "monocyte", "xrefs" : [ "PMID:22343568" ] } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001059", "lbl" : "common myeloid progenitor, CD34-positive", "type" : "CLASS", "meta" : { "definition" : { "val" : "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1.", "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:tfm", "ISBN:0878932437", "PMCID:PMC2212039", "PMID:10724173", "PMID:16551251", "PMID:16647566" ] }, "comments" : [ "CMP are reportedly CD16-positive, CD32-positive, CD38-positive, CD45RA-negative, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative." ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "CMP", "xrefs" : [ "ISBN:0878932437" ] }, { "pred" : "hasExactSynonym", "val" : "common myeloid precursor, CD34-positive" }, { "pred" : "hasRelatedSynonym", "val" : "CFU-GEMM", "xrefs" : [ "ISBN:0878932437" ] }, { "pred" : "hasRelatedSynonym", "val" : "CFU-S", "xrefs" : [ "ISBN:0878932437" ] }, { "pred" : "hasRelatedSynonym", "val" : "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte", "xrefs" : [ "ISBN:0878932437" ] }, { "pred" : "hasRelatedSynonym", "val" : "multipotential myeloid stem cell", "xrefs" : [ "ISBN:0878932437" ] }, { "pred" : "hasRelatedSynonym", "val" : "myeloid stem cell", "xrefs" : [ "ISBN:0878932437" ] }, { "pred" : "hasRelatedSynonym", "val" : "pluripotent stem cell (bone marrow)", "xrefs" : [ "ISBN:0878932437" ] } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001060", "lbl" : "hematopoietic oligopotent progenitor cell, lineage-negative", "type" : "CLASS", "meta" : { "definition" : { "val" : "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers.", "xrefs" : [ "GOC:tfm", "PMID:19022770" ] }, "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-01-06T03:43:27Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001061", "lbl" : "abnormal cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cell found in an organism or derived from an organism exhibiting a phenotype that deviates from the expected phenotype of any native cell type of that organism. Abnormal cells are typically found in disease states or disease models.", "xrefs" : [ "GOC:add", "GOC:cg", "GOC:wdd" ] }, "comments" : [ "https://github.com/obophenotype/cell-ontology/issues/448" ], "xrefs" : [ { "val" : "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12913" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0001-9990-8331" }, { "pred" : "http://purl.org/dc/terms/date", "val" : "2017-01-30T18:53:32Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001063", "lbl" : "neoplastic cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "An abnormal cell exhibiting dysregulation of cell proliferation or programmed cell death and capable of forming a neoplasm, an aggregate of cells in the form of a tumor mass or an excess number of abnormal cells (liquid tumor) within an organism.", "xrefs" : [ "GOC:add", "GOC:cg", "GOC:wdd" ] }, "comments" : [ "https://github.com/obophenotype/cell-ontology/issues/448" ], "synonyms" : [ { "pred" : "hasRelatedSynonym", "val" : "tumor cell" }, { "pred" : "hasRelatedSynonym", "val" : "tumour cell" } ], "xrefs" : [ { "val" : "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12922" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0001-9990-8331" }, { "pred" : "http://purl.org/dc/terms/date", "val" : "2017-01-30T19:16:26Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001064", "lbl" : "malignant cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A neoplastic cell that is capable of entering a surrounding tissue", "xrefs" : [ "GOC:add", "GOC:cg", "GOC:wdd" ] }, "comments" : [ "https://github.com/obophenotype/cell-ontology/issues/448" ], "synonyms" : [ { "pred" : "hasRelatedSynonym", "val" : "cancer cell" } ], "xrefs" : [ { "val" : "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12917" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0001-9990-8331" }, { "pred" : "http://purl.org/dc/terms/date", "val" : "2017-01-30T19:39:12Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001066", "lbl" : "erythroid progenitor cell, mammalian", "type" : "CLASS", "meta" : { "definition" : { "val" : "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative).", "xrefs" : [ "GOC:add", "ISBN:0721601464" ] }, "synonyms" : [ { "pred" : "hasRelatedSynonym", "val" : "BFU-E" }, { "pred" : "hasRelatedSynonym", "val" : "CFU-E" }, { "pred" : "hasRelatedSynonym", "val" : "blast forming unit erythroid" }, { "pred" : "hasRelatedSynonym", "val" : "burst forming unit erythroid" }, { "pred" : "hasRelatedSynonym", "val" : "colony forming unit erythroid" }, { "pred" : "hasRelatedSynonym", "val" : "erythroid stem cell" } ], "xrefs" : [ { "val" : "BTO:0004911" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002000", "lbl" : "Kit-positive erythroid progenitor cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative.", "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:19805084", "http://www.immgen.org/index_content.html" ] }, "comments" : [ "Markers found on mouse cells." ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "c- Kit-positive erythroid progenitor cell" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-04-26T10:14:16Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002001", "lbl" : "CD34-positive, CD38-positive granulocyte monocyte progenitor", "type" : "CLASS", "meta" : { "definition" : { "val" : "A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative.", "xrefs" : [ "GOC:tfm", "PMID:12615892", "PMID:19022770" ] }, "comments" : [ "Markers are for human cells. According to different research groups, CD45RA is present or absent on this cell population." ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-01-13T03:19:22Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002005", "lbl" : "CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative.", "xrefs" : [ "GOC:tfm", "PMID:12615892", "PMID:190227700" ] }, "comments" : [ "Markers are associated with human cell type." ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : 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myeloid dendritic cells, and to monocytes and macrophages.", "xrefs" : [ "GOC:tfm", "PMID:19273628" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "MDP" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-01-19T02:51:58Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002012", "lbl" : "Kit-low proerythroblast", "type" : "CLASS", "meta" : { "definition" : { "val" : "A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive.", "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:19805084" ] }, "comments" : [ "Markers are associated with mouse cells." ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-04-26T10:31:56Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002014", "lbl" : "Kit-negative, Ly-76 high basophilic erythroblast", "type" : "CLASS", "meta" : { "definition" : { "val" : "A basophilic erythroblast that is Lyg 76-high and is Kit-negative.", "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:19805084" ] }, "comments" : [ "Cell surface markers are associated with mouse cells." ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-04-26T10:41:22Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002015", "lbl" : "Kit-negative, Ly-76 high polychromatophilic erythroblast", "type" : "CLASS", "meta" : { "definition" : { "val" : "A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative.", "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:19805084" ] }, "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "late basophilic and polychromatophilic 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"meta" : { "definition" : { "val" : "A reticulocyte that is Ly76-high and is Kit-negative.", "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:18539294" ] }, "comments" : [ "Marker associated with mouse cells." ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-04-26T11:37:00Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002022", "lbl" : "Ly-76 high positive erythrocyte", "type" : "CLASS", "meta" : { "definition" : { "val" : "An enucleate erythrocyte that is Lyg-76-high.", "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:19805084" ] }, "comments" : [ "Marker is associated with mouse cell types." ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-04-26T11:51:27Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002031", "lbl" : "hematopoietic lineage restricted progenitor cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells.", "xrefs" : [ "GOC:tfm", "PMID:19022770" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim" ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-01-06T03:43:20Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002032", "lbl" : "hematopoietic oligopotent progenitor cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities.", "xrefs" : [ "GOC:tfm", "PMID:19022770", "https://orcid.org/0000-0001-5208-3432" ] }, "comments" : [ "This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060)." ], "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim" ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-01-06T03:43:27Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002033", "lbl" : "short term hematopoietic stem cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative.", "xrefs" : [ "GOC:tfm", "PMID:15572596", "PMID:19022770" ] }, "comments" : [ "Markers are associated with mouse cells. These cells are also reportedly CD11b-low and CD90-low." ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "ST stem cell" }, { "pred" : "hasExactSynonym", "val" : "ST-HSC" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-01-08T09:19:25Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002034", "lbl" : "long term hematopoietic stem cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative.", "xrefs" : [ "GOC:tfm", "PMID:15572596", "PMID:17582345" ] }, "comments" : [ "Markers are associated with mouse cells." ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "LT stem cell" }, { "pred" : "hasExactSynonym", "val" : "LT-HSC" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-01-08T09:19:28Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002035", "lbl" : "Slamf1-negative multipotent progenitor cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative.", "xrefs" : [ "GOC:tfm", "PMID:19022770" ] }, "comments" : [ "Markers are associated with mouse cells." ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-01-08T11:16:33Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002036", "lbl" : "Slamf1-positive multipotent progenitor cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive.", "xrefs" : [ "GOC:tfm", "PMID:19022770" ] }, "comments" : [ "Markers are associated with mouse cells." ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "KSL cell" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-01-08T11:16:35Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002043", "lbl" : "CD34-positive, CD38-negative multipotent progenitor cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative.", "xrefs" : [ "GOC:tfm", "PMID:18371405", "PMID:19022770" ] }, "comments" : [ "Cell markers are associated with human hematopoietic multipotent progenitor cells." ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-01-12T11:14:15Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002064", "lbl" : "pancreatic acinar cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules.", "xrefs" : [ "GOC:tfm", "ISBN:0517223651", "PMID:20395539", "http://www.copewithcytokines.de/cope.cgi?key=pancreatic%20acinar%20cells" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "acinar cell of pancreas" } ], "xrefs" : [ { "val" : "BTO:0000028" }, { "val" : "CALOHA:TS-0737" }, { "val" : "FMA:63032" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" }, { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-06-24T03:16:29Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002067", "lbl" : "type A enteroendocrine cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "An enteroendocrine cell that produces glucagon.", "xrefs" : [ "GOC:tfm", "ISBN:0412046911" ] }, "xrefs" : [ { "val" : "FMA:62939" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-09-10T10:48:54Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002068", "lbl" : "Purkinje myocyte", "type" : "CLASS", "meta" : { "definition" : { "val" : "Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. 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The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery.", "xrefs" : [ "FMA:67101", "GOC:tfm" ] }, "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "pacemaker cell" }, { "pred" : "hasExactSynonym", "val" : "P cell" }, { "pred" : "hasExactSynonym", "val" : "cardiac pacemaker cell", "xrefs" : [ "GOC:pr" ] }, { "pred" : "hasExactSynonym", "val" : "myocytus nodalis" } ], "xrefs" : [ { "val" : "BTO:0004190" }, { "val" : "FMA:67101" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-06-29T11:41:37Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002073", "lbl" : "transitional myocyte", "type" : "CLASS", "meta" : { "definition" : { "val" : "Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. 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This cell type secretes collagen I, V, VI, and keratin sulfate.", "xrefs" : [ "GOC:tfm", "ISBN:978-0-7020-2958-5" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "corneal fibroblast" }, { "pred" : "hasExactSynonym", "val" : "corneal keratocyte" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" }, { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-09-22T01:57:40Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002368", "lbl" : "respiratory epithelial cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "An endo-epithelial cell of the respiratory tract.", "xrefs" : [ "GOC:tfm" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "airway epithelial cell" } ], "xrefs" : [ { "val" : "BTO:0004533" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-09-23T04:38:49Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002371", "lbl" : "somatic cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cell of an organism that does not pass on its genetic material to the organism's offspring (i.e. a non-germ line cell).", "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/ubprop#_upper_level" ], "xrefs" : [ { "val" : "BTO:0001268" }, { "val" : "FMA:72300" }, { "val" : "WBbt:0008378" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-09-24T09:44:42Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002372", "lbl" : "myotube", "type" : "CLASS", "meta" : { "definition" : { "val" : "A transversely striated, synctial muscle cell, formed by the fusion of myoblasts.", "xrefs" : [ "GOC:dos", "GOC:tfm", "ISBN:0323052908", "PMID:22274696" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "myotubule" }, { "pred" : "hasExactSynonym", "val" : "single cell sarcomere" } ], "xrefs" : [ { "val" : "FBbt:00005812" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-09-24T01:13:01Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002375", "lbl" : "Schwann cell precursor", "type" : "CLASS", "meta" : { "definition" : { "val" : "A giioblast cell that develops from a migratory neural crest cell. The SCP is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has no basal lamina. In rodents SCPs are the only cells in the Schwann cell linage that expresses Cdh19.", "xrefs" : [ "GOC:tfm" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "Schwann cell precursor cell" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-09-24T02:06:10Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002377", "lbl" : "immature Schwann cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A glial cell that develops from a Schwann cell precursor. The immature Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. Immature Schwann cell can be found communally ensheathing large groups of axons.", "xrefs" : [ "GOC:cvs", "GOC:tfm", "ISBN:0721662544" ] }, "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "Schwann cell" } ], "xrefs" : [ { "val" : "ZFA:0001725" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-09-24T02:10:31Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002421", "lbl" : "nucleated reticulocyte", "type" : "CLASS", "meta" : { "definition" : { "val" : "A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles.", "xrefs" : [ "GOC:tfm", "PMID:18182572", "PMID:9011180", "PMID:9046052" ] }, "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-10-15T09:24:05Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002422", "lbl" : "enucleated reticulocyte", "type" : "CLASS", "meta" : { "definition" : { "val" : "A reticulocyte lacking a nucleus and showing a basophilic reticulum under vital staining due to the presence of ribosomes.", "xrefs" : [ "GOC:tfm", "ISBN:0-12203-052-4", "ISBN:0721601464" ] }, "xrefs" : [ { "val" : "CALOHA:TS-0864" }, { "val" : "FMA:66785" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-10-15T09:24:08Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002453", "lbl" : "oligodendrocyte precursor cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A progenitor cell of the central nervous system that can differentiate into oligodendrocytes or type-2 astrocytes. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons.", "xrefs" : [ "GOC:tfm", "PMID:10704434", "PMID:11756508", "PMID:20142420", "PMID:2182078", "PMID:24133281", "PMID:9826671" ] }, "comments" : [ "This cell type can be purified from optic nerves and other regions of the embryonic, postnatal and adult rat CNS and can be differentiated in vitro to oligodendrocytes and type-2 astrocytes. Some references use the terms 'oligodendrocyte precursor cell' and 'oligodendrocyte type-2 astrocyte (O-2A) progenitor' to refer to the same entity (e.g., PMID:10704434), while others describe an oligodendrocyte type-2 astrocyte (O-2A) progenitor cell as the precurosr to oligodendrocyte- and type-2 astrocyte- progenitor cells (e.g, ISBN:9780702028991)." ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "O-2A/OPC", "xrefs" : [ "PMID:24133281" ] }, { "pred" : "hasBroadSynonym", "val" : "O2A/OPC", "xrefs" : [ "PMID:11756508" ] }, { "pred" : "hasBroadSynonym", "val" : "oligodendrocyte-type 2 astrocyte (O-2A) progenitor cell", "xrefs" : [ "PMID:2253328" ] }, { "pred" : "hasBroadSynonym", "val" : "oligodendrocyte/type-2 astrocyte progenitor cell", "xrefs" : [ "PMID:24133281" ] } ], "xrefs" : [ { "val" : "MESH:D000073637" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-1773-2692" }, { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-11-10T02:51:34Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002454", "lbl" : "Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8_alpha-negative and is CD205-positive.", "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "DC.8-4-11b+" }, { "pred" : "hasExactSynonym", "val" : "spleen double-negative dendritic cell" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-11-22T01:10:28Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002465", "lbl" : "CD11b-positive dendritic cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A conventional dendritic cell that expresses CD11b (ITGAM).", "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ] }, "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-11-23T01:50:05Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002482", "lbl" : "dermal melanocyte", "type" : "CLASS", "meta" : { "definition" : { "val" : "A melanocyte that produces pigment in the dermis.", "xrefs" : [ "GOC:cjm", "GOC:tfm", "MP:0009386" ] }, "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-12-03T03:17:05Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002484", "lbl" : "epithelial melanocyte", "type" : "CLASS", "meta" : { "definition" : { "val" : "A melanocyte that produces pigment in the epithelium.", "xrefs" : [ "GOC:tfm", "MP:0009388" ] }, "comments" : [ "The text defintion reference to the MP term appears to reference an epidermal melanocyte term. This term represents any melanocyte in any epithelium." ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-12-03T03:17:14Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002485", "lbl" : "retinal melanocyte", "type" : "CLASS", "meta" : { "definition" : { "val" : "A melanocyte of the retina. This cell type is distinct from pigmented retinal epithelium.", "xrefs" : [ "GOC:tfm", "MP:0010190" ] }, "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-12-03T03:25:32Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002494", "lbl" : "cardiocyte", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cell located in the heart, including both muscle and non muscle cells.", "xrefs" : [ "GOC:tfm" ] }, "comments" : [ "From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart." ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "heart cell" } ], "xrefs" : [ { "val" : "BTO:0001539" }, { "val" : "CALOHA:TS-0115" }, { "val" : "FMA:83808" }, { "val" : "FMA:84791" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-12-07T09:37:22Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002503", "lbl" : "adventitial cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc", "xrefs" : [ "GOC:tfm" ] }, "xrefs" : [ { "val" : "BTO:0002441" }, { "val" : "FMA:84639" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-12-07T04:03:56Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002504", "lbl" : "enteric smooth muscle cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A smooth muscle cell of the intestine.", "xrefs" : [ "GOC:tfm" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "intestinal smooth muscle cell" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2011-01-17T03:39:38Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002521", "lbl" : "subcutaneous fat cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A fat cell that is part of subcutaneous adipose tissue.", "xrefs" : [ "GOC:tfm" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "subcutaneous adipocyte" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" }, { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2011-02-21T02:51:22Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002538", "lbl" : "intrahepatic cholangiocyte", "type" : "CLASS", "meta" : { "definition" : { "val" : "An epithelial cell of the intrahepatic portion of the bile duct. These cells are flattened or cuboidal in shape, and have a small nuclear-to-cytoplasmic ratio relative to large/extrahepatic cholangiocytes.", "xrefs" : [ "GOC:tfm", "PMID:23720296" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "small bile duct cholangiocyte", "xrefs" : [ "PMID:23720296" ] } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2011-02-28T01:20:20Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002539", "lbl" : "aortic smooth muscle cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A smooth muscle cell of the aorta.", "xrefs" : [ "GOC:tfm" ] }, "xrefs" : [ { "val" : "BTO:0004577" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2011-02-28T01:42:12Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002540", "lbl" : "mesenchymal stem cell of the bone marrow", "type" : "CLASS", "meta" : { "definition" : { "val" : "A mesenchymal stem cell that is part of the bone marrow.", "xrefs" : [ "GOC:tfm" ] }, "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2011-02-28T01:47:47Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002541", "lbl" : "chorionic membrane mesenchymal stem cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A mesenchymal stem cell of the chorionic membrane.", "xrefs" : [ "GOC:tfm" ] }, "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2011-02-28T03:04:35Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002543", "lbl" : "vein endothelial cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "An endothelial cell that is part of the vein.", "xrefs" : [ "GOC:tfm" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "endothelial cell of vein" }, { "pred" : "hasExactSynonym", "val" : "venous endothelial cell" } ], "xrefs" : [ { "val" : "FMA:62104" }, { "val" : "KUPO:0001099" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" }, { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2011-02-28T03:48:11Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002546", "lbl" : "embryonic blood vessel endothelial progenitor cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "An endothelial progenitor cell that participates in angiogenesis during development.", "xrefs" : [ "GOC:tfm" ] }, "comments" : [ "See CL:0002619." ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2011-02-28T04:20:39Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002547", "lbl" : "fibroblast of the aortic adventitia", "type" : "CLASS", "meta" : { "definition" : { "val" : "A fibroblast of the aortic adventitia.", "xrefs" : [ "GOC:tfm" ] }, "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2011-02-28T04:43:41Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002548", "lbl" : "fibroblast of cardiac 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"https://orcid.org/0000-0001-7258-9596" }, { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-5260-9315" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cell" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0004247", "lbl" : "bistratified cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A neuron that stratifies dendrites at two and only two locations.", "xrefs" : [ "PMID:9620701", "https://orcid.org/0000-0002-5260-9315" ] }, "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0001-7258-9596" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cell" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0005000", "lbl" : "spinal cord interneuron", "type" : "CLASS", "meta" : { "definition" : { "val" : "A CNS interneuron located in the spinal cord.", "xrefs" : [ "CL:CVS" ] }, "comments" : [ "Is_a interneuron, part_of UBERON:0002240." ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0005012", "lbl" : "multi-ciliated epithelial cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A ciliated epithelial cell with many cilia.", "xrefs" : [ "CL:CVS" ] }, "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "MCC" }, { "pred" : "hasBroadSynonym", "val" : "multi-ciliated cell" }, { "pred" : "hasBroadSynonym", "val" : "multiciliated cell" }, { "pred" : "hasExactSynonym", "val" : "multiciliated epithelial cell" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0005024", "lbl" : "somatomotor neuron", "type" : "CLASS", "meta" : { "definition" : { "val" : "A motor neuron that innervates a skeletal muscle. These motor neurons are all excitatory and cholinergic.", "xrefs" : [ "ZFIN:CVS" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "somatic motor neuron" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0005026", "lbl" : "hepatoblast", "type" : "CLASS", "meta" : { "definition" : { "val" : "Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation.", "xrefs" : [ "GOC:CVS", "PMID:18356246", "PMID:20483998", "PMID:26798363", "https://orcid.org/0000-0003-1940-6740" ] }, "basicPropertyValues" : [ { "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso", "val" : "https://github.com/obophenotype/cell-ontology/issues/800" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0007001", "lbl" : "skeletogenic cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized).", "xrefs" : [ "GO_REF:0000034" ] }, "comments" : [ "Needs logical definition. Should be capable_of skeletal system morphogenesis? or skeletal tissue development? needs to be added to GO. NOTES:a cell type of the early embryo (see also: mesenchymal cells) that will give rise to mineralized connective tissue. Scleroblasts can differentiate into osteoblasts (bone-forming cells), chondroblasts (cartilage-forming cells), odontoblasts (dentin-forming cells), ameloblasts (enamel-forming cells). The mesenchymal cells developing into osteoblasts and chondroblasts are derived from the mesoderm. Those developing into odontoblasts are neural crest cells. Those developing into ameloblasts are derived from the ectoderm. (http://www.copewithcytokines.de/cope.cgi?key=scleroblasts)" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "scleroblast", "xrefs" : [ "GO_REF:0000034" ] } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0001-9114-8737" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-06-15T02:51:27Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0007004", "lbl" : "premigratory neural crest cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells.", "xrefs" : [ "UBERONREF:0000002" ] }, "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0001-9114-8737" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-06-27T08:27:35Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0007009", "lbl" : "prechondroblast", "type" : "CLASS", "meta" : { "definition" : { "val" : "Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells.", "xrefs" : [ "GO_REF:0000034" ] }, "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0001-9114-8737" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-06-27T10:44:01Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008000", "lbl" : "non-striated muscle cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any muscle cell in which the fibers are not organised into sarcomeres.", "xrefs" : [ "GOC:DOS" ] } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008001", "lbl" : "hematopoietic precursor cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any hematopoietic cell that is a precursor of some other hematopoietic cell type.", "xrefs" : [ "GOC:dos" ] } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008002", "lbl" : "skeletal muscle fiber", "type" : "CLASS", "meta" : { "definition" : { "val" : "A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.", "xrefs" : [ "GOC:tfm", "ISBN:0323052908" ] }, "xrefs" : [ { "val" : "MESH:D018485" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008007", "lbl" : "visceral muscle cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A muscle cell that is part of some visceral muscle.", "xrefs" : [ "GOC:dos" ] }, "xrefs" : [ { "val" : "FBbt:00005070" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008008", "lbl" : "striated visceral muscle cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A visceral muscle cell that is striated. Examples include the visceral muscle cells of arhtropods.", "xrefs" : [ "GOC:dos" ] } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008009", "lbl" : "transversely striated visceral muscle cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A visceral muscle that is transversely striated. Examples include the visceral muscle cells of arthropods.", "xrefs" : [ "GOC:dos" ] } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008017", "lbl" : "adult skeletal muscle myoblast", "type" : "CLASS", "meta" : { "definition" : { "val" : "A skeletal muscle myoblast that is part of a skeletal mucle. These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers.", "xrefs" : [ "PMID:23303905" ] }, "comments" : [ "The vast majority of these cells develop from skeletal muscle satellite cells, although there are some reports of other origins." ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "myogenic precursor cell", "xrefs" : [ "PMID:23303905" ] } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008019", "lbl" : "mesenchymal cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration." }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "mesenchyme cell" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008022", "lbl" : "endocardial cushion cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A mesenchymal cell of the endocardial cushion. These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves.", "xrefs" : [ "PMID:18816864" ] } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008024", "lbl" : "pancreatic endocrine cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "An endocrine cell that is part of the pancreas.", "xrefs" : [ "GOC:dos" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008025", "lbl" : "noradrenergic neuron", "type" : "CLASS", "meta" : { "definition" : { "val" : "A neuron that release noradrenaline (noriphinephrine) as a neurotransmitter.", "xrefs" : [ "GOC:dos" ] } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008028", "lbl" : "visual system neuron", "type" : "CLASS", "meta" : { "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-7073-9172" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2017-07-09T19:12:36Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008031", "lbl" : "cortical interneuron", "type" : "CLASS", "meta" : { "definition" : { "val" : "An interneuron that has its soma located in the cerebral cortex." }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "cerebral cortex interneuron" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008034", "lbl" : "mural cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation.", "xrefs" : [ "Wiki:Mural_cell&oldid=930603194" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/cl#added_for_HCA", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" }, { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-7073-9172" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2020-02-29T17:33:55Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008035", "lbl" : "microcirculation associated smooth muscle cell", "type" : "CLASS", "meta" : { "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-7073-9172" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2020-02-29T17:37:00Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009000", "lbl" : "sensory neuron of spinal nerve", "type" : "CLASS", "meta" : { "definition" : { "val" : "A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord.", "xrefs" : [ "GOC:nv", "GOC:pr" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "spinal sensory neuron" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009001", "lbl" : "compound eye retinal cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any cell in the compound eye, a light sensing organ composed of ommatidia." }, "xrefs" : [ { "val" : "GOC:pr" }, { "val" : "PMID:12021768" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009004", "lbl" : "retinal cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.", "xrefs" : [ "GOC:pr" ] }, "xrefs" : [ { "val" : "PMID:10702418" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009006", "lbl" : "enteroendocrine cell of small intestine", "type" : "CLASS", "meta" : { "definition" : { "val" : "An enteroendocrine cell that is located in the small intestine.", "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "small intestine enteroendocrine cell" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-2825-0621" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009018", "lbl" : "lymphocyte of large intestine lamina propria", "type" : "CLASS", "meta" : { "definition" : { "val" : "A lymphocyte that resides in the lamina propria of the large intestine.", "xrefs" : [ "https://orcid.org/0000-0003-4183-8865" ] }, "comments" : [ "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ], "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "lamina propria lymphocyte of large intestine" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" }, { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-2825-0621" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009021", "lbl" : "stromal cell of lamina propria of large intestine", "type" : "CLASS", "meta" : { "definition" : { "val" : "A stromal cell found in the lamina propria of the large intestine.", "xrefs" : [ "http://orcid.org/0000-0003-4183-8865" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-2825-0621" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009022", "lbl" : "stromal cell of lamina propria of small intestine", "type" : "CLASS", "meta" : { "definition" : { "val" : "A stromal cell found in the lamina propria of the small intestine.", "xrefs" : [ "http://orcid.org/0000-0003-4183-8865" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-2825-0621" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009024", "lbl" : "mesothelial cell of small intestine", "type" : "CLASS", "meta" : { "definition" : { "val" : "A mesothelial cell that is part of the small intestine.", "xrefs" : [ "http://orcid.org/0000-0003-4183-8865" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-2825-0621" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009025", "lbl" : "mesothelial cell of colon", "type" : "CLASS", "meta" : { "definition" : { "val" : "A mesothelial cell that is part of the colon.", "xrefs" : [ "http://orcid.org/0000-0003-3440-1876", "http://orcid.org/0000-0003-4183-8865" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "mesothelial cell of large intestine" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-2825-0621" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009038", "lbl" : "colon macrophage", "type" : "CLASS", "meta" : { "definition" : { "val" : "A macrophage that is located in the colon.", "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] }, "comments" : [ "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ], "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "macrophage of colon" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-2825-0621" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009040", "lbl" : "stromal cell of lamina propria of colon", "type" : "CLASS", "meta" : { "definition" : { "val" : "A stromal cell found in the lamina propria of the colon.", "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "stromal cell of colon lamina propria" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-2825-0621" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009042", "lbl" : "enteroendocrine cell of colon", "type" : "CLASS", "meta" : { "definition" : { "val" : "An enteroendocrine cell that is located in the colon.", "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "colon enteroendocrine cell" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-2825-0621" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009044", "lbl" : "lymphocyte of small intestine lamina propria", "type" : "CLASS", "meta" : { "definition" : { "val" : "A lymphocyte that resides in the lamina propria of the small intestine. Lamina propria leukocytes and intraepithelial lymphocytes are the effector compartments of the gut mucosal immune system. Lymphocytes circulate through gut associated lymphoid tissues until recruitment by intestinal antigens. They are involved in the gut immune response.", "xrefs" : [ "PMID:26551552", "https://orcid.org/0000-0003-4183-8865" ] }, "comments" : [ "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ], "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "gastrointestinal tract small intestine (lamina propria) leukocyte" }, { "pred" : "hasBroadSynonym", "val" : "small intestine lamina propria leukocyte" }, { "pred" : "hasBroadSynonym", "val" : "small intestine lamina propria leukocyte (LPL)" }, { "pred" : "hasExactSynonym", "val" : "gastrointestinal tract (lamina propria) lymphocyte of small intestine" }, { "pred" : "hasExactSynonym", "val" : "lamina propria lymphocyte of small intestine" }, { "pred" : "hasExactSynonym", "val" : "small intestine lamina propria lymphocyte" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-2825-0621" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009048", "lbl" : "anorectum macrophage", "type" : "CLASS", "meta" : { "definition" : { "val" : "A macrophage that is located in the anorectum.", "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] }, "comments" : [ "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ], "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "macrophage of anorectum" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-2825-0621" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009051", "lbl" : "T cell of anorectum", "type" : "CLASS", "meta" : { "definition" : { "val" : "A T cell that is located in the anorectum.", "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] }, "comments" : [ "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ], "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-2825-0621" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009052", "lbl" : "smooth muscle cell of anorectum", "type" : "CLASS", "meta" : { "definition" : { "val" : "A smooth muscle cell that is located in the anorectum.", "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "anorectum smooth muscle cell" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-2825-0621" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009053", "lbl" : "stromal cell of anorectum lamina propria", "type" : "CLASS", "meta" : { "definition" : { "val" : "A stromal cell found in the lamina propria of the anorectum.", "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-2825-0621" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009063", "lbl" : "enteroendocrine cell of anorectum", "type" : "CLASS", "meta" : { "definition" : { "val" : "An enteroendocrine cell that is located in the anorectum.", "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "anorectum enteroendocrine cell" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-2825-0621" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009066", "lbl" : "stratified squamous epithelial cell of anal canal", "type" : "CLASS", "meta" : { "definition" : { "val" : "A stratified squamous epithelial cell that is part of the anal canal.", "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] }, "comments" : [ "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ], "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "anal canal stratified squamous epithelial cell" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-2825-0621" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009084", "lbl" : "epithelial cell of endometrial gland", "type" : "CLASS", "meta" : { "definition" : { "val" : "An epithelial cell that is part of an endometrial gland.", "xrefs" : [ "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "endometrial glandular epithelial cell" } ], "xrefs" : [ { "val" : "EFO:0010710" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-2825-0621" }, { "pred" : "http://purl.org/dc/terms/date", "val" : "2021-11-30T16:13:30Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009092", "lbl" : "endothelial cell of placenta", "type" : "CLASS", "meta" : { "definition" : { "val" : "An endothelial cell that is part of a placenta.", "xrefs" : [ "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "placental endothelial cell" } ], "xrefs" : [ { "val" : "EFO:0010708" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-2825-0621" }, { "pred" : "http://purl.org/dc/terms/date", "val" : "2021-12-13T13:53:01Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009093", "lbl" : "smooth muscle cell of placenta", "type" : "CLASS", "meta" : { "definition" : { "val" : "A smooth muscle cell that is part of a placenta.", "xrefs" : [ "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "placental smooth muscle cell" } ], "xrefs" : [ { "val" : "EFO:0010709" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-2825-0621" }, { "pred" : "http://purl.org/dc/terms/date", "val" : "2021-12-13T13:56:42Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009094", "lbl" : "endothelial cell of hepatic portal vein", "type" : "CLASS", "meta" : { "definition" : { "val" : "An endothelial cell that is part of a hepatic portal vein.", "xrefs" : [ "PMID:30348985", "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "portal endothelial cell" } ], "xrefs" : [ { "val" : "EFO:0010704" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-2825-0621" }, { "pred" : "http://purl.org/dc/terms/date", "val" : "2021-12-13T14:01:05Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009095", "lbl" : "endothelial cell of uterus", "type" : "CLASS", "meta" : { "definition" : { "val" : "An endothelial cell that is part of a uterus.", "xrefs" : [ "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "uterine endothelial cell" } ], "xrefs" : [ { "val" : "EFO:0010711" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-2825-0621" }, { "pred" : "http://purl.org/dc/terms/date", "val" : "2021-12-13T14:39:25Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009097", "lbl" : "embryonic skeletal muscle fiber", "type" : "CLASS", "meta" : { "definition" : { "val" : "A skeletal muscle fiber found in an embryo. In mammalian embryos, skeletal muscle expresses myosin heavy chain-embryonic (MyHC-emb, encoded by the MYH3 gene), which regulates skeletal muscle development.", "xrefs" : [ "PMID:32094117", "PMID:7196501", "http://orcid.org/0000-0003-2034-601X" ] }, "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-2825-0621" }, { "pred" : "http://purl.org/dc/terms/date", "val" : "2022-02-21T15:39:10Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009100", "lbl" : "hepatic portal fibroblast", "type" : "CLASS", "meta" : { "definition" : { "val" : "A fibroblast located in the portal triad. Hepatic portal fibroblast are a non-parenchymal cell population located adjacent to bile duct epithelia in liver and are distinct from stellate cells. They differentiate into fibrogenic myofibroblasts during chronic injury states producing high levels of collagen.", "xrefs" : [ "PMID:20209607", "PMID:24814904", "https://orcid.org/0000-0001-7655-4833" ] }, "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "portal fibroblast" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-2825-0621" }, { "pred" : "http://purl.org/dc/terms/date", "val" : "2022-03-17T12:00:44Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0010001", "lbl" : "stromal cell of bone marrow", "type" : "CLASS", "meta" : { "definition" : { "val" : "A stromal cell that is part_of a bone marrow." }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "bone marrow stromal cell" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-6601-2165" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0010004", "lbl" : "mononuclear cell of bone marrow", "type" : "CLASS", "meta" : { "definition" : { "val" : "A mononuclear cell that is part_of a bone marrow." }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "bone marrow mononuclear cell" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-6601-2165" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0010006", "lbl" : "cardiac blood vessel endothelial cell", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CL_0010007", "lbl" : "His-Purkinje system cell", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CL_0010008", "lbl" : "cardiac endothelial cell", "type" : "CLASS", "meta" : { "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0010009", "lbl" : "camera-type eye photoreceptor cell", "type" : "CLASS", "meta" : { "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "camera type eye photoreceptor cell" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0010012", "lbl" : "cerebral cortex neuron", "type" : "CLASS", "meta" : { "definition" : { "val" : "A CNS neuron of the cerebral cortex.", "xrefs" : [ "GOC:tfm" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "cortical neuron" }, { "pred" : "hasExactSynonym", "val" : "neuron of cerebral cortex" } ], "xrefs" : [ { "val" : "BTO:0004102" }, { "val" : "FMA:84104" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0001-7258-9596" }, { "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso", "val" : "https://github.com/obophenotype/cell-ontology/issues/1359" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0010017", "lbl" : "zygote", "type" : "CLASS", "meta" : { "definition" : { "val" : "A zygote in a plant or an animal." }, "xrefs" : [ { "val" : "MESH:D015053" } ], "basicPropertyValues" : [ { "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso", "val" : "https://github.com/obophenotype/cell-ontology/issues/786" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0010020", "lbl" : "cardiac glial cell", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CL_0010021", "lbl" : "cardiac myoblast", "type" : "CLASS", "meta" : { "xrefs" : [ { "val" : "MESH:D032386" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0010022", "lbl" : "cardiac neuron", "type" : "CLASS", "meta" : { "definition" : { "val" : "A neuron that has its soma in the heart.", "xrefs" : [ "PMID:12486170", "PMID:29265764" ] }, "comments" : [ "This term is used in 3 GO terms that were created as part of the heart development focus project." ], "basicPropertyValues" : [ { "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso", "val" : "https://github.com/obophenotype/cell-ontology/pull/1488" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0011001", "lbl" : "spinal cord motor neuron", "type" : "CLASS", "meta" : { "definition" : { "val" : "A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement.", "xrefs" : [ "GOC:nv" ] } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0011007", "lbl" : "paraxial cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites.", "xrefs" : [ "GOC:NV", "PMID:11687492" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "paraxial mesoderm cell" }, { "pred" : "hasExactSynonym", "val" : "somitic mesoderm cell" }, { "pred" : "hasNarrowSynonym", "val" : "presomitic mesoderm cell" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0011012", "lbl" : "neural crest cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells.", "xrefs" : [ "https://orcid.org/0000-0001-5208-3432", "https://orcid.org/0000-0002-9900-7880" ] } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0011019", "lbl" : "mesothelial cell of epicardium", "type" : "CLASS", "meta" : { "definition" : { "val" : "A mesothelial cell that is part of the epicardium." }, "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0001-5208-3432" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0011021", "lbl" : "fibroblast of upper back skin", "type" : "CLASS", "meta" : { "definition" : { "val" : "A fibroblast that is part of upper back skin." }, "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0001-5208-3432" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0011022", "lbl" : "fibroblast of skin of back", "type" : "CLASS", "meta" : { "definition" : { "val" : "A fibroblast that is part of skin of back." }, "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0001-5208-3432" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0011026", "lbl" : "progenitor cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses.", "xrefs" : [ "ISBN:978-1-62808-994-3", "https://doi.org/10.1016/B978-0-12-409503-8.00002-0" ] }, "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0001-5208-3432" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0011027", "lbl" : "skeletal muscle fibroblast", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any fibroblast that is part of skeletal muscle tissue.", "xrefs" : [ "PMID:28369879", "https://orcid.org/0000-0001-6164-0667" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "skeleton muscle fibroblast" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0001-5208-3432" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0011030", "lbl" : "dermal microvascular endothelial cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any microvascular endothelial cell that is part of the dermis.", "xrefs" : [ "BTO:0004574", "CL:patterns/cellPartOfAnatomicalEntity" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "DMEC cell" }, { "pred" : "hasExactSynonym", "val" : "dermal microvascular endothelium cell" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0001-5208-3432" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0011101", "lbl" : "chorionic trophoblast cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "Cells of the uterine chorion that acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer.", "xrefs" : [ "GOC:NV" ] } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0011108", "lbl" : "colon epithelial cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "Epithelial cell that is part of the colon epithelium.", "xrefs" : [ "GOC:NV" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "colonic epithelial cell" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0011115", "lbl" : "precursor cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cell that, by division or terminal differentiation, can give rise to other cell types.", "xrefs" : [ "GOC:dos" ] }, "comments" : [ "Work is needed on GO 'cell differentiation' before it is clear whether the equivalent class definition 'native cell' that capable_of some 'cell differentiation' works. Also, may want to consider merging this with non-terminally differentiated cell." ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0012001", "lbl" : "neuron of the forebrain", "type" : "CLASS", "meta" : { "definition" : { "val" : "A CNS neuron of the forebrain." }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "forebrain neuron" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0002-3837-8864" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0017500", "lbl" : "neutrophillic cytoplasm", "type" : "CLASS", "meta" : { "definition" : { "val" : "Cytoplasm that exhibits a characteristic staining and color, pale-pink, with Wright-Giemsa stain.", "xrefs" : [ "GOC:add" ] }, "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-05-25T01:36:34Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0017502", "lbl" : "acidophilic cytoplasm", "type" : "CLASS", "meta" : { "definition" : { "val" : "Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain.", "xrefs" : [ "GOC:add" ] }, "synonyms" : [ { "pred" : "hasNarrowSynonym", "val" : "eosinophilic" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2009-12-22T04:23:25Z" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0017503", "lbl" : "basophilic cytoplasm", "type" : "CLASS", "meta" : { "definition" : { "val" : "Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions.", "xrefs" : [ "GOC:tfm" ] }, "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" }, { "pred" : 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endothelial cell that is part of an arterial endothelium.", "xrefs" : [ "GOC:tfm" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "arterial endothelial cell" } ], "xrefs" : [ { "val" : "BTO:0004758" }, { "val" : "FMA:67761" }, { "val" : "KUPO:0001095" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000414", "lbl" : "endothelial cell of venule", "type" : "CLASS", "meta" : { "definition" : { "val" : "An endothelial cell that is part of the venule.", "xrefs" : [ "GOC:tfm" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "xrefs" : [ { "val" : "FMA:67762" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000415", "lbl" : "epithelial cell of gallbladder", "type" : "CLASS", "meta" : { "definition" : { "val" : "An epithelial cell that is part of the gallbladder.", "xrefs" : [ "GOC:tfm" ] }, "xrefs" : [ { "val" : "FMA:67780" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000428", "lbl" : "stem cell of epidermis", "type" : "CLASS", "meta" : { "definition" : { "val" : "A somatic stem cell that is part of the epidermis.", "xrefs" : [ "GOC:tfm" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "epidermal stem cell", "xrefs" : [ "FMA:70541" ] } ], "xrefs" : [ { "val" : "FMA:70541" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000443", "lbl" : "ciliary muscle cell", "type" : "CLASS", "meta" : { "definition" : { "val" : "A smooth muscle cell that is part of the ciliary body.", "xrefs" : [ "GOC:tfm" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "smooth muscle cell of ciliary body", "xrefs" : [ "FMA:70610" ] } ], "xrefs" : [ { 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"type" : "CLASS", "m