An ontology of phenotypic qualities (properties, attributes or characteristics).
x is the opposite of y if there exists some distance metric M, and there exists no z such as M(x,z) <= M(x,y) or M(y,z) <= M(y,x).
Relational slim: types of quality that require an additional entity in order to exist
a core relation that holds between a part and its whole
part of
a core relation that holds between a whole and its part
has part
x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
preceded by
x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
precedes
b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t
Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant
occurs in
[copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t
Paraphrase of definition: a relation between an independent continuant and a process, in which the process takes place entirely within the independent continuant
contains process
a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence.
Note that this relation was previously called "inheres in", but was changed to be called "characteristic of" because BFO2 uses "inheres in" in a more restricted fashion. This relation differs from BFO2:inheres_in in two respects: (1) it does not impose a range constraint, and thus it allows qualities of processes, as well as of information entities, whereas BFO2 restricts inheres_in to only apply to independent continuants (2) it is declared functional, i.e. something can only be a characteristic of one thing.
characteristic of
Inverse of characteristic_of
has characteristic
a relation between a continuant and a process, in which the continuant is somehow involved in the process
participates in
a relation between a process and a continuant, in which the continuant is somehow involved in the process
has participant
a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence
This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020.
quality of
a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence
role of
a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence
has quality
a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence
has role
a relation between two independent continuants, the location and the target, in which the target is entirely within the location
location of
a relation between two independent continuants, the target and the location, in which the target is entirely within the location
located in
a relation between a 2D immaterial entity (the boundary) and a material entity, in which the boundary delimits the material entity
2D boundary of
a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity
has 2D boundary
innervated_by
has synaptic terminal of
X outer_layer_of Y iff: . X :continuant that bearer_of some PATO:laminar . X part_of Y . exists Z :surface . X has_boundary Z . Z boundary_of Y has_boundary: http://purl.obolibrary.org/obo/RO_0002002 boundary_of: http://purl.obolibrary.org/obo/RO_0002000
A relationship that applies between a continuant and its outer, bounding layer. Examples include the relationship between a multicellular organism and its integument, between an animal cell and its plasma membrane, and between a membrane bound organelle and its outer/bounding membrane.
bounding layer of
A relationship between a process and a barrier, where the process occurs in a region spanning the barrier. For cellular processes the barrier is typically a membrane. Examples include transport across a membrane and membrane depolarization.
Primitive instance level timing relation between events
before or simultaneous with
x simultaneous with y iff ω(x) = ω(y) and ω(α ) = ω(α), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point and '=' indicates the same instance in time.
t1 simultaneous_with t2 iff:= t1 before_or_simultaneous_with t2 and not (t1 before t2)
simultaneous with
X ends_after Y iff: end(Y) before_or_simultaneous_with end(X)
ends after
X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)
immediately preceded by
X immediately_precedes_Y iff: end(X) simultaneous_with start(Y)
immediately precedes
Relation between a neuron and a material anatomical entity that its soma is part of.
has soma location
Relation between a neuron and some structure its axon forms (chemical) synapses in.
axon synapses in
Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it.
synapsed by
Holds between a cell c and a protein complex or protein p if and only if that cell has as part a plasma_membrane[GO:0005886], and that plasma membrane has p as part.
has plasma membrane part
Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input.
has postsynaptic terminal in
has presynaptic terminal in
Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to.
N1 synapsed_to some N2 Expands to: N1 SubclassOf ( has_part some ( ‘pre-synaptic membrane ; GO:0042734’ that part_of some ( ‘synapse ; GO:0045202’ that has_part some ( ‘post-synaptic membrane ; GO:0045211’ that part_of some N2))))
synapsed to
A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input.
has synaptic terminal in
x overlaps y if and only if there exists some z such that x has part z and z part of y
overlaps
Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
innervates
X continuous_with Y if and only if X and Y share a fiat boundary.
continuous with
x only in taxon y if and only if x is in taxon y, and there is no other organism z such that y!=z a and x is in taxon z.
x is in taxon y if an only if y is an organism, and the relationship between x and y is one of: part of (reflexive), developmentally preceded by, derives from, secreted by, expressed.
life cycle stage of
Connects a biological entity to its taxon of origin.
A is spatially_disjoint_from B if and only if they have no parts in common
a is connected to b if and only if a and b are discrete structure, and there exists some connecting structure c, such that c connects a and b
connected to
c connects a if and only if there exist some b such that a and b are similar parts of the same system, and c connects b, specifically, c connects a with b. When one structure connects two others it unites some aspect of the function or role they play within the system.
connects
a is attached to part of b if a is attached to b, or a is attached to some p, where p is part of b.
attached to part of
Relation between an arterial structure and another structure, where the arterial structure acts as a conduit channeling fluid, substance or energy.
supplies
Relation between an collecting structure and another structure, where the collecting structure acts as a conduit channeling fluid, substance or energy away from the other structure.
drains
w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type.
has component
x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y
This is the transitive form of the develops from relation
develops from
develops into
Candidate definition: x directly_develops from y if and only if there exists some developmental process (GO:0032502) p such that x and y both participate in p, and x is the output of p and y is the input of p, and a substantial portion of the matter of x comes from y, and the start of x is coincident with or after the end of y.
directly develops from
directly develops into
p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q.
regulates
p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q.
negatively regulates
p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q.
positively regulates
A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process.
capable of
c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p.
capable of part of
x surrounded_by y if and only if (1) x is adjacent to y and for every region r that is adjacent to x, r overlaps y (2) the shared boundary between x and y occupies the majority of the outermost boundary of x
surrounded by
x adjacent to y if and only if x and y share a boundary.
adjacent to
surrounds
A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations.
temporally related to
starts
x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
starts with
x develops from part of y if and only if there exists some z such that x develops from z and z is part of y
develops from part of
x develops_in y if x is located in y whilst x is developing
develops in
ends
x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
ends with
x 'has starts location' y if and only if there exists some process z such that x 'starts with' z and z 'occurs in' y
has start location
x 'has end location' y if and only if there exists some process z such that x 'ends with' z and z 'occurs in' y
has end location
p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p.
has input
p has output c iff c is a participant in p, c is present at the end of p, and c is not present in the same state at the beginning of p.
has output
b connecting-branch-of s iff b is connected to s, and there exists some tree-like structure t such that the mereological sum of b plus s is either the same as t or a branching-part-of t.
x has developmental contribution from y iff x has some part z such that z develops from y
has developmental contribution from
inverse of has developmental contribution from
developmentally contributes to
t1 induced_by t2 if there is a process of developmental induction (GO:0031128) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor material anatomical entity type T to T', where T' develops_from T
developmentally induced by
Inverse of developmentally induced by
developmentally induces
Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p
This relation groups together various other developmental relations. It is fairly generic, encompassing induction, developmental contribution and direct and transitive develops from
developmentally preceded by
x developmentally replaces y if and only if there is some developmental process that causes x to move or to cease to exist, and for the site that was occupied by x to become occupied by y, where y either comes into existence in this site or moves to this site from somewhere else
developmentally replaces
developmentally succeeded by
part of developmental precursor of
p results in the developmental progression of s iff p is a developmental process and s is an anatomical entity and p causes s to undergo a change in state at some point along its natural developmental cycle (this cycle starts with its formation, through the mature structure, and ends with its loss).
results in developmental progression of
p 'results in development of' c if and only if p is a developmental process and p results in the state of c changing from its initial state as a primordium or anlage through its mature state and to its final state.
results in development of
results in formation of anatomical entity
The relationship that links an entity with the process that results in the formation and shaping of that entity over time from an immature to a mature state.
results in morphogenesis of
The relationship that links an entity with a process that results in the progression of the entity over time that is independent of changes in it's shape and results in an end point state of that entity.
results in maturation of
p is causally upstream of, positive effect q iff p is casually upstream of q, and the execution of p is required for the execution of q.
holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y
p is causally upstream of, negative effect q iff p is casually upstream of q, and the execution of p decreases the execution of q.
q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w.
characteristic of part of
The relationship that links a specified entity with the process that results in an unspecified entity acquiring the features and characteristics of the specified entity
results in acquisition of features of
A relationship that holds via some environmental process
evolutionarily related to
A mereological relationship or a topological relationship
mereotopologically related to
A relationship that holds between entities participating in some developmental process (GO:0032502)
developmentally related to
A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities.
functionally related to
this relation holds between c and p when c is part of some c', and c' is capable of p.
part of structure that is capable of
regulated by
negatively regulated by
positively regulated by
A relationship that holds via some process of localization
related via localization to
This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from some initial location l to some destination.
has target start location
This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from a an initial location to some destination l.
has target end location
Holds between p and l when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that is aligned_with l
results in transport along
Holds between p and m when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that crosses m.
results in transport across
results in growth of
results in transport to from or in
is member of is a mereological relation between a item and a collection.
member of
has member is a mereological relation between a collection and an item.
has member
input of
output of
formed as result of
a is attached to b if and only if a and b are discrete objects or object parts, and there are physical connections between a and b such that a force pulling a will move b, or a force pulling b will move a
attached to
m has_muscle_origin s iff m is attached_to s, and it is the case that when m contracts, s does not move. The site of the origin tends to be more proximal and have greater mass than what the other end attaches to.
has muscle origin
We need to import uberon muscle to create a stricter domain constraint
m has_muscle_insertion s iff m is attaches_to s, and it is the case that when m contracts, s moves. Insertions are usually connections of muscle via tendon to bone.
has muscle insertion
A relationship that holds between two material entities in a system of connected structures, where the branching relationship holds based on properties of the connecting network.
in branching relationship with
x tributary_of y if and only if x a channel for the flow of a substance into y, where y is larger than x. If x and y are hydrographic features, then y is the main stem of a river, or a lake or bay, but not the sea or ocean. If x and y are anatomical, then y is a vein.
tributary of
x spatially_coextensive_with y if and inly if x and y have the same location
spatially coextensive with
x is a branching part of y if and only if x is part of y and x is connected directly or indirectly to the main stem of y
branching part of
x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction).
has developmental potential involving
x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y
has potential to developmentally contribute to
x has potential to developmentally induce y iff x developmentally induces y or x is capable of developmentally inducing y
has potential to developmentally induce
x has the potential to develop into y iff x develops into y or if x is capable of developing into y
This relation has a stronger meaning than merely indicating that X may develop into Y, in that the capability of developing into Y is always present, even if X does not always actually develop into Y. In particular, this means that if Y is restricted to a given taxon T, X is necessarily likewise restricted.
has potential to develop into
x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y
has potential to directly develop into
causally downstream of
relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause.
causally related to
p is causally upstream of q iff p is causally related to q, the end of p precedes the end of q, and p is not an occurrent part of q.
causally upstream of
p is 'causally upstream or within' q iff p is causally related to q, and the end of p precedes, or is coincident with, the end of q.
inverse of causally upstream of or within
p contributes to morphology of w if and only if a change in the morphology of p entails a change in the morphology of w. Examples: every skull contributes to morphology of the head which it is a part of. Counter-example: nuclei do not generally contribute to the morphology of the cell they are part of, as they are buffered by cytoplasm.
x composed_primarily_of y if and only if more than half of the mass of x is made from y or units of the same type as y.
p has part that occurs in c if and only if there exists some p1, such that p has_part p1, and p1 occurs in c.
relation between physical entity and a process or stage
x existence starts during y if and only if the time point at which x starts is after or equivalent to the time point at which y starts and before or equivalent to the time point at which y ends. Formally: x existence starts during y iff α(x) >= α(y) & α(x) <= ω(y).
x starts ends with y if and only if the time point at which x starts is equivalent to the time point at which y starts. Formally: x existence starts with y iff α(x) = α(y).
x existence overlaps y if and only if either (a) the start of x is part of y or (b) the end of x is part of y. Formally: x existence starts and ends during y iff (α(x) >= α(y) & α(x) <= ω(y)) OR (ω(x) <= ω(y) & ω(x) >= α(y))
The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription.
x exists during y if and only if: 1) the time point at which x begins to exist is after or equal to the time point at which y begins and 2) the time point at which x ceases to exist is before or equal to the point at which y ends. Formally: x existence starts and ends during y iff α(x) >= α(y) & α(x) <= ω(y) & ω(x) <= ω(y) & ω(x) >= α(y)
x existence ends during y if and only if the time point at which x ends is before or equivalent to the time point at which y ends and after or equivalent to the point at which y starts. Formally: x existence ends during y iff ω(x) <= ω(y) and ω(x) >= α(y).
x existence ends with y if and only if the time point at which x ends is equivalent to the time point at which y ends. Formally: x existence ends with y iff ω(x) = ω(y).
x transformation of y if x is the immediate transformation of y, or is linked to y through a chain of transformation relationships
x immediate transformation of y iff x immediately succeeds y temporally at a time boundary t, and all of the matter present in x at t is present in y at t, and all the matter in y at t is present in x at t
x existence starts during or after y if and only if the time point at which x starts is after or equivalent to the time point at which y starts. Formally: x existence starts during or after y iff α (x) >= α (y).
x existence ends during or before y if and only if the time point at which x ends is before or equivalent to the time point at which y ends.
A relationship between a material entity and a process where the material entity has some causal role that influences the process
p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one where the execution of p influences the execution of q. p may be upstream, downstream, part of, or a container of q.
q towards e2 if and only if q is a relational quality such that q inheres-in some e, and e != e2 and q is dependent on e2
A relation between a segment or subdivision of an organism and the maximal subdivision of material entities that provides structural support for that segment or subdivision.
Holds between p and c when p is locomotion process and the outcome of this process is the change of location of c
A relation that holds between elements of a musculoskeletal system or its analogs.
x is a conduit for y iff y overlaps through the lumen_of of x, and y has parts on either side of the lumen of x.
x lumen_of y iff x is the space or substance that is part of y and does not cross any of the inner membranes or boundaries of y that is maximal with respect to the volume of the convex hull.
s is luminal space of x iff s is lumen_of x and s is an immaterial entity
s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p
p results in breakdown of c if and only if the execution of p leads to c no longer being present at the end of p
p results in organization of c iff p results in the assembly, arrangement of constituent parts, or disassembly of c
A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity.
causal relation between material entity and a process
Holds between c and p if and only if c is capable of some activity a, and a regulates p.
Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p.
Holds between c and p if and only if c is capable of some activity a, and a positively regulates p.
A relationship that holds between two entities, where the entities exhibit a statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes.
a produces b if some process that occurs_in a has_output b, where a and b are material entities. Examples: hybridoma cell line produces monoclonal antibody reagent; chondroblast produces avascular GAG-rich matrix.
Note that this definition doesn't quite distinguish the output of a transformation process from a production process, which is related to the identity/granularity issue.
produces
a produced_by b iff some process that occurs_in b has_output a.
produced by
p 'has primary input ot output' c iff either (a) p 'has primary input' c or (b) p 'has primary output' c.
p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c.
p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c.
A relationship between a realizable entity R (e.g. function or disposition) and a material entity M where R is realized in response to a process that has an input stimulus of M.
causally upstream of or within, negative effect
causally upstream of or within, positive effect
r 'realized in response to' s iff, r is a realizable (e.g. a plant trait such as responsivity to drought), s is an environmental stimulus (a process), and s directly causes the realization of r.
realized in response to
p acts on population of c iff c' is a collection, has members of type c, and p has participant c
acts on population of
results in fusion of
A relation that applies between a cell type and a set of markers that can be used to uniquely identify that cell type.
q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
This relation is used to determine the 'directionality' of relative qualities such as 'increased strength', relative to the parent type, 'strength'.
q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) < magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
This relation is used to determine the 'directionality' of relative qualities such as 'decreased strength', relative to the parent type, 'strength'.
q1 similar_in_magnitude_relative_to q2 if and only if magnitude(q1) =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2.
Example: a spherical object has the quality of being spherical, and the spherical quality has_cross_section round.
q1 reciprocal_of q2 if and only if : q1 and q2 are relational qualities and a phenotype e q1 e2 mutually implies a phenotype e2 q2 e.
There are frequently two ways to state the same thing: we can say 'spermatocyte lacks asters' or 'asters absent from spermatocyte'. In this case the quality is 'lacking all parts of type' - it is a (relational) quality of the spermatocyte, and it is with respect to instances of 'aster'. One of the popular requirements of PATO is that it continue to support 'absent', so we need to relate statements which use this quality to the 'lacking all parts of type' quality.
X device utilizes material Y means X and Y are material entities, and X is capable of some process P that has input Y.
device utilizes material
x vessel supplies blood to y if and only if x is a vessel that supplies blood directly or indirectly to an anatomical structure y.
x vessel drains blood from y if and only if x is a vessel that drains blood directly or indirectly from an anatomical structure y.
p has anatomical participant c iff p has participant c, and c is an anatomical entity
results in changes to anatomical or cellular structure
Consider using RO:0002610 instead. See https://github.com/pato-ontology/pato/issues/454
OBSOLETE. q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) < magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
Refer to https://github.com/pato-ontology/pato/issues/454 for obsoletion reason. This relation is used to determine the 'directionality' of relative qualities such as 'decreased strength', relative to the parent type, 'strength'.
obsolete decreased_in_magnitude_relative_to
OBSOLETE. q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
Refer to https://github.com/pato-ontology/pato/issues/454 for obsoletion reason.
obsolete different_in_magnitude_relative_to
OBSOLETE. q1 directly_associated_with q2 iff q1 is dependent on q2, and the magnitude of q1 increases if the magnitude of q2 is increased, or the magnitude of q1 decreases if the magnitude of q2 is decreased. The relationship is not necessarily linear.
refer to https://github.com/pato-ontology/pato/issues/454 for obsoletion reason. OBSOLETE. Example: 'Lewy bodies increased number related to dystrophic neurite increased number' (from annotation of PMID:8740227 in http://ccdb.ucsd.edu/1.0/NDPO.owl#ndpo_404). Here the increase in the number of lewy bodies is directly_associated_with the increase in the number of dystrophic neurites. Association is weaker than correlation or proportionality. These relations may be later added to PATO.
OBSOLETE. s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2.
Refer to https://github.com/pato-ontology/pato/issues/454. Example: a spherical object has the quality of being spherical, and the spherical quality has_cross_section round.
Refer to https://github.com/pato-ontology/pato/issues/454.
OBSOLETE. q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
Refer to https://github.com/pato-ontology/pato/issues/454. This relation is used to determine the 'directionality' of relative qualities such as 'increased strength', relative to the parent type, 'strength'.
obsolete increased_in_magnitude_relative_to
OBSOLETE. q1 inversely_associated_with q2 iff q1 is dependent on q2, and the magnitude of q1 decreases if the magnitude of q2 is increased, or the magnitude of q1 increases if the magnitude of q2 is decreased. The relationship is not necessarily linear.
Consider using RO:0009501 instead. See https://github.com/pato-ontology/pato/issues/454
OBSOLETE. q1 reciprocal_of q2 if and only if : q1 and q2 are relational qualities and a phenotype e q1 e2 mutually implies a phenotype e2 q2 e.
Refer to https://github.com/pato-ontology/pato/issues/454. There are frequently two ways to state the same thing: we can say 'spermatocyte lacks asters' or 'asters absent from spermatocyte'. In this case the quality is 'lacking all parts of type' - it is a (relational) quality of the spermatocyte, and it is with respect to instances of 'aster'. One of the popular requirements of PATO is that it continue to support 'absent', so we need to relate statements which use this quality to the 'lacking all parts of type' quality.
OBSOLETE. q1 similar_in_magnitude_relative_to q2 if and only if magnitude(q1) =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
obsolete similar_in_magnitude_relative_to
refer to https://github.com/pato-ontology/pato/issues/454 for obsoletion reason. OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qualities and relational qualities. Relational qualities stand in the 'towards' relation with respect to some additional entity. For example, The sensitivity of an eye towards red light. In some cases we want to represent a quality such as 'protruding' in both monadic and relational branches. We use this relation to link them.
Consider using RO:0002503 instead. See https://github.com/pato-ontology/pato/issues/454
x anteriorly_connected_to y iff the anterior part of x is connected to y. i.e. x connected_to y and x posterior_to y.
x distally_connected_to y iff the distal part of x is connected to y. i.e. x connected_to y and x proximal_to y.
X extends_fibers into Y iff there exists some neuron (N) and N has_soma_location X and N 'has synaptic IO in region' some Y
Relationship between a fluid and a material entity, where the fluid is the output of a realization of a filtration role that inheres in the material entity.
Relationship between a fluid and a filtration barrier, where the portion of fluid arises as a transformation of another portion of fluid on the other side of the barrier, with larger particles removed
x posteriorly_connected_to y iff the posterior part of x is connected to y. i.e. x connected_to y and x anterior_to y.
x proximally_connected_to y iff the proximal part of x is connected to y. i.e. x connected_to y and x distal_to y.
c site_of p if c is the bearer of a disposition that is realized by a process that has p as part.
placeholder relation. X = 'subdivision of A' and subdivision_of some B means that X is the mereological sum of A and B
Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV.
A carbohydrate acid derivative anion obtained by deprotonation of the carboxy groups of hyaluronic acid; major species at pH 7.3.
A Bronsted acid derived from one or more inorganic compounds. Inorganic acids (also known as mineral acids) form hydrons and conjugate base ions when dissolved in water.
Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0degreeC and 100 kPa).
A molecular entity that can accept an electron, a pair of electrons, an atom or a group from another molecular entity.
Actylcholine is an ester of acetic acid and choline, which acts as a neurotransmitter.
A simple monocarboxylic acid containing two carbons.
A peptide containing ten or more amino acid residues.
A nucleobase-containing molecular entity with a polymeric structure comprised of a linear sequence of 13 or more nucleotide residues.
An azane that consists of a single nitrogen atom covelently bonded to three hydrogen atoms.
A sulfur oxoanion obtained by deprotonation of both OH groups of sulfuric acid.
A mucopolysaccharide composed of N-acetylglucosamine and glucuronic acid subunits. It is found in the connective tissues of vertebrates. A principal constituent of the extracellular matrix (ECM), it mediates the growth and metastasis of tumour cells.
A naturally occurring polypeptide synthesized at the ribosome.
Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula Cm(H2O)n. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates.
Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc.
Any oligosaccharide, polysaccharide or their derivatives consisting of monosaccharides or monosaccharide derivatives linked by glycosidic bonds. See also http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001.
An aminoalkylindole consisting of indole having a 2-aminoethyl group at the 3-position.
A compound in which a carbohydrate component is covalently bound to a protein component.
A molecular entity that can transfer ("donate") an electron, a pair of electrons, an atom or a group to another molecular entity.
'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids.
Any polysaccharide containing a substantial proportion of aminomonosaccharide residues.
A biomacromolecule consisting of large numbers of monosaccharide residues linked glycosidically. This term is commonly used only for those containing more than ten monosaccharide residues.
That part of DNA or RNA that may be involved in pairing.
An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure RkE(=O)l(OH)m (l =/= 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids.
Any of the naturally occurring, basic nitrogen compounds (mostly heterocyclic) occurring mostly in the plant kingdom, but also found in bacteria, fungi, and animals. By extension, certain neutral compounds biogenetically related to basic alkaloids are also classed as alkaloids. Amino acids, peptides, proteins, nucleotides, nucleic acids, amino sugars and antibiotics are not normally regarded as alkaloids. Compounds in which the nitrogen is exocyclic (dopamine, mescaline, serotonin, etc.) are usually classed as amines rather than alkaloids.
A monoatomic or polyatomic species having one or more elementary charges of the electron.
A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Bronsted base) or with the vacant orbital of some other molecular entity (Lewis base).
Any compound that produces a peak used as reference frequency in the delta chemical shift scale.
The univalent carboacyl group formed by loss of -OH from the carboxy group of carbamic acid.
An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group).
Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity.
Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances.
A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances.
A role played by the molecular entity or part thereof within a biological context.
A defined linked collection of atoms or a single atom within a molecular entity.
A cyclic compound having as ring members atoms of carbon and at least of one other element.
A heterodetic cyclic peptide is a peptide consisting only of amino-acid residues, but in which the linkages forming the ring are not solely peptide bonds; one or more is an isopeptide, disulfide, ester, or other bond.
Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.
Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-)).
Any compound containing an indole skeleton.
A compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
A molecular entity that contains no carbon.
A molecular entity having a net electric charge.
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
A molecule all atoms of which have the same atomic number.
Any polyatomic entity that is an electrically neutral entity consisting of more than one atom.
A group of neurotransmitters and neuromodulators that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan.
An oxoacid containing a single carboxy group.
An endogenous compound that is used to transmit information across the synapse between a neuron and another cell.
Any organic ion with a net negative charge.
Any organic ion with a net positive charge.
Compounds of the general formula SO3HOR where R is an organyl group
An oxide is a chemical compound of oxygen with other chemical elements.
Any peptide with hormonal activity in animals, whether endocrine, neuroendocrine, or paracrine.
An ester of an alcohol and sulfuric acid.
A sulfur oxoacid that consists of two oxo and two hydroxy groups joined covalently to a central sulfur atom.
Any nutrient required in small quantities by organisms throughout their life in order to orchestrate a range of physiological functions.
Tryptamine and its substitution derivatives.
A univalent carboacyl group is a group formed by loss of OH from the carboxy group of a carboxylic acid.
A neutral compound having formal unit electrical charges of opposite sign on non-adjacent atoms. Sometimes referred to as inner salts, dipolar ions (a misnomer).
A one-carbon compound that is ammonia in which one of the hydrogens is replaced by a carboxy group. Although carbamic acid derivatives are common, carbamic acid itself has never been synthesised.
A primary amino compound that is the 5-hydroxy derivative of tryptamine.
An onium cation obtained by protonation of ammonia.
The conjugate base formed when the carboxy group of a carboxylic acid is deprotonated.
A divalent inorganic anion resulting from the removal of two protons from ammonia.
A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of acetic acid.
Particle of zero charge, zero rest mass, spin quantum number 1, energy hnu and momentum hnu/c (h is the Planck constant, nu the frequency of radiation and c the speed of light), carrier of electromagnetic force.
A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.
An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group.
Intended use of the molecular entity or part thereof by humans.
A particle not known to have substructure.
A monoatomic entity is a molecular entity consisting of a single atom.
Any substituent group which does not contain carbon.
Any substituent group or skeleton containing carbon.
Any organic substituent group, regardless of functional type, having one free valence at a carbon atom.
A chemical entity constituting the smallest component of an element having the chemical properties of the element.
A nucleus is the positively charged central portion of an atom, excluding the orbital electrons.
Heavy nuclear particle: proton or neutron.
A derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group.
A molecular entity all atoms of which have the same atomic number.
An anion consisting of more than one atom.
A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
A nutrient is a food component that an organism uses to survive and grow.
A heteroorganic entity is an organic molecular entity in which carbon atoms or organic groups are bonded directly to one or more heteroatoms.
Any p-block element atom that is in group 15 of the periodic table: nitrogen, phosphorus, arsenic, antimony and bismuth.
A p-block molecular entity containing any pnictogen.
Any p-block element belonging to the group 16 family of the periodic table.
Any p-block molecular entity containing a chalcogen.
An ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl.
An atom belonging to one of the main groups (found in the s- and p- blocks) of the periodic table.
An amino-acid anion obtained by deprotonation of any alpha-amino acid.
Any main group element atom belonging to the p-block of the periodic table.
Any compound containing an o-diphenol component.
4-(2-Aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution.
A catecholamine in which C-1 of the aminoethyl side-chain is hydroxy-substituted.
A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid.
A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table.
Any molecule that consists of a series of atoms joined together to form a ring.
A molecule that features two fused rings.
A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekule structure) is said to possess aromatic character.
A polycyclic compound in which at least one of the rings contains at least one non-carbon atom.
A bicyclic compound in which at least one of the rings contains at least one skeletal heteroatom.
An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element.
A main group molecular entity that contains one or more atoms of a p-block element.
Hydrides are chemical compounds of hydrogen with other chemical elements.
A macromolecule formed by a living organism.
A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid.
High molecular weight, linear polymers, composed of nucleotides containing ribose and linked by phosphodiester bonds; RNA is central to the synthesis of proteins.
A cation consisting of more than one atom.
An amino acid in which the amino group is located on the carbon atom at the position alpha to the carboxy group.
When two or more amino acids combine to form a peptide, the elements of water are removed, and what remains of each amino acid is called an amino-acid residue.
A carboxylic acid containing one or more amino groups.
An amino-acid residue derived from an alpha-amino acid.
An organic compound having at least one hydroxy group attached to a carbon atom.
Any organic molecule that consists of atoms connected in the form of a ring.
A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2).
Conjugated protein is a protein that contains a non-peptide component, usually in stoichiometric proportion.
A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring.
A substance used in a chemical reaction to detect, measure, examine, or produce other substances.
Any nutrient required in large quantities by organisms throughout their life in order to orchestrate a range of physiological functions. Macronutrients are usually chemical elements (carbon, hydrogen, nitrogen, oxygen, phosphorus and sulfur) that humans consume in the largest quantities. Calcium, sodium, magnesium and potassium are sometimes included as macronutrients because they are required in relatively large quantities compared with other vitamins and minerals.
An ammonium ion that is the conjugate acid of serotonin; major species at pH 7.3.
Saturated acyclic nitrogen hydrides having the general formula NnHn+2.
A substance that diminishes the rate of a chemical reaction.
A substance that increases the rate of a reaction without modifying the overall standard Gibbs energy change in the reaction.
The zwitterionic form of an amino acid having a negatively charged carboxyl group and a positively charged amino group.
A derivative of ammonium, NH4(+), in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups.
A derivative of ammonium, NH4(+), in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc).
A choline ester formed from choline and a carboxylic acid.
Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene which is a triterpene.
Any heteroorganic entity containing at least one carbon-nitrogen bond.
An oxoanion is an anion derived from an oxoacid by loss of hydron(s) bound to oxygen.
A substance that reduces or suppresses inflammation.
A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume.
An agent that selectively binds to and activates alpha-adrenergic receptors.
A drug used to cause dilation of the blood vessels.
A compound formally derived from an oxoacid RkE(=O)l(OH)m (l > 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter.
A carboxylic acid anion formed when the carboxy group of a monocarboxylic acid is deprotonated.
A substance used for its pharmacological action on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.
A biological macromolecule minimally consisting of one polypeptide chain synthesized at the ribosome.
Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek lambdaepsilonpitauomicronsigma (small, thin).
Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek betaalpharhoupsilonsigma (heavy).
Particle of half-integer spin quantum number following Fermi-Dirac statistics. Fermions are named after Enrico Fermi.
Particle of integer spin quantum number following Bose-Einstein statistics. Bosons are named after Satyendra Nath Bose.
A subatomic particle known to have substructure (i.e. consisting of smaller particles).
Hadron is a subatomic particle which experiences the strong force.
A nucleus or any of its constituents in any of their energy states.
Any molecular entity consisting of more than one atom.
An ion consisting of more than one atom.
Any compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives.
Organic compounds containing an oxygen atom, =O, doubly bonded to carbon or another element.
A monoatomic or polyatomic species having one or more elementary charges of the proton.
An organochalcogen compound is a compound containing at least one carbon-chalcogen bond.
An organochalcogen compound containing at least one carbon-oxygen bond.
Any of the group of polysaccharides composed of alternating units from uronic acids and glycosamines, and commonly partially esterified with sulfuric acid.
An acid is a molecular entity capable of donating a hydron (Bronsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid).
A molecular entity consisting of two or more chemical elements.
An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the -C(=O)NH2 group including its carbon atom.
A carboacyl group is a group formed by loss of at least one OH from the carboxy group of a carboxylic acid.
An agent that selectively binds to and activates adrenergic receptors.
Any agent that acts on an adrenergic receptor or affects the life cycle of an adrenergic transmitter.
Any organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms.
Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons.
Any drug that binds to and activates cholinergic receptors.
Any drug that binds to and activates a muscarinic cholinergic receptor.
muscarinic acetylcholine receptor agonist
An alkaloid containing an indole skeleton.
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
A molecular entity able to provide a pair of electrons and thus capable of forming a covalent bond with an electron-pair acceptor (Lewis acid), thereby producing a Lewis adduct.
In general, a mineral is a chemical substance that is normally crystalline formed and has been formed as a result of geological processes. The term also includes metamict substances (naturally occurring, formerly crystalline substances whose crystallinity has been destroyed by ionising radiation) and can include naturally occurring amorphous substances that have never been crystalline ('mineraloids') such as georgite and calciouranoite as well as substances formed by the action of geological processes on bigenic compounds ('biogenic minerals').
A liquid that can dissolve other substances (solutes) without any change in their chemical composition.
Any carboxylic ester where the carboxylic acid component is acetic acid.
A solvent that is composed of polar molecules. Polar solvents can dissolve ionic compounds or ionisable covalent compounds.
A polar solvent that is capable of acting as a hydron (proton) donor.
Any drug that acts on an alpha-adrenergic receptor.
Substance which binds to cell receptors normally responding to naturally occurring substances and which produces a response of its own.
A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups.
Mononuclear cations derived by addition of a hydron to a mononuclear parent hydride of the pnictogen, chalcogen and halogen families.
Drug used to cause constriction of the blood vessels.
Any molecular entity that contains carbon.
A role is particular behaviour which a material entity may exhibit.
A poison that interferes with the functions of the nervous system.
A compound formally derived from ammonia by replacing one hydrogen atom by an organyl group.
A role played by the molecular entity or part thereof within a chemical context.
An organic molecule that is electrically neutral carrying a positive and a negative charge in one of its major canonical descriptions. In most dipolar compounds the charges are delocalized; however the term is also applied to species where this is not the case.
Any organic substituent group, regardless of functional type, having two free valences at carbon atom(s).
A biological role played by the molecular entity or part thereof within a biochemical context.
A role played by the molecular entity or part thereof which causes the development of a pathological process.
A biological role which describes how a drug interacts within a biological system and how the interactions affect its medicinal properties.
Any substance introduced into a living organism with therapeutic or diagnostic purpose.
A phosphate mineral with the general formula Ca5(PO4)3X where X = OH, F or Cl.
A phosphate mineral with the formula Ca5(PO4)3(OH).
An organic group that consists of a closed ring. It may be a substituent or a skeleton.
A polymer carrying multiple negative charges.
A macromolecule containing ionic groups.
A 29-amino acid peptide hormone consisting of His, Ser, Gln, Gly, Thr, Phe, Thr, Ser, Asp, Tyr, Ser, Lys, Tyr, Leu, Asp, Ser, Arg, Arg, Ala, Gln, Asp, Phe, Val, Gln, Trp, Leu, Met, Asn and Thr residues joined in sequence.
A cyclic compound having as ring members atoms of at least two different elements.
An ammonium ion that is the conjugate acid of tryptamine arising from protonation of the primary amino group; major species at pH 7.3.
An amino-acid residue protonated on nitrogen.
An organic anion of general formula RS(=O)2O(-) where R is an organyl group.
A reagent that forms a bond to its reaction partner (the electrophile) by donating both bonding electrons.
A chemical substance is a portion of matter of constant composition, composed of molecular entities of the same type or of different types.
A mixture is a chemical substance composed of multiple molecules, at least two of which are of a different kind.
A polymer is a mixture, which is composed of macromolecules of different kinds and which may be differentiated by composition, length, degree of branching etc..
An ionic polymer is a polymer, composed of ionic macromolecules.
An atom or small molecule with a positive charge that does not contain carbon in covalent linkage, with a valency of one.
Zwitterionic form of any peptide where, in general, the amino terminus is positively charged and the carboxy terminus is negatively charged.
Any compound that has a nucleobase as a part.
nucleobase-containing molecular entities
A polymer, composed of polyanion macromolecules.
A substance that removes electrons from another reactant in a redox reaction.
Any organooxygen compound derived from a carbohydrate by replacement of one or more hydroxy group(s) by an amino group, a thiol group or similar heteroatomic groups. The term also includes derivatives of these compounds.
A carbohydrate derivative that is formally obtained from a carbohydrate acid.
An aralylamino compound which contains one amino group connected to an aromatic ring by a two-carbon chain. Monoamines are derived from aromatic amino acids like phenylalanine, tyrosine, tryptophan, and the thyroid hormones by the action of aromatic amino acid decarboxylase enzymes.
A carboxylic acid anion resulting from the deprotonation of the carboxy group of a carbohydrate acid derivative.
Any substance which is added to food to preserve or enhance its flavour and/or appearance.
A food additive that is used to change or otherwise control the acidity or alkalinity of foods. They may be acids, bases, neutralising agents or buffering agents.
An organic amino compound in which an aminoalkyl group is linked to an arene.
A fourteen-membered heterodetic cyclic peptide comprising the sequence Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys cyclised by a disulfide bridge between the two Cys residues at positions 3 and 14.
L-alanylglycyl-L-cysteinyl-L-lysyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-cysteine cyclic (3-14) disulfide
Synthetic growth hormone release-inhibiting hormone
An organic molecular entity containing a single carbon atom (C1).
Any organic molecular entity that is acidic and contains carbon in covalent linkage.
A group that carries an overall positive charge.
A group that carries an overall negative charge.
An amino-acid residue carrying an overall negative charge.
Any substance that causes disturbance to organisms by chemical reaction or other activity on the molecular scale, when a sufficient quantity is absorbed by the organism.
A carbohydrate derivative that is any derivative of a polysaccharide.
Substances which are added to food in order to prevent decomposition caused by microbial growth or by undesirable chemical changes.
A food preservative which prevents decomposition of food by preventing the growth of fungi or bacteria. In European countries, E-numbers for permitted food preservatives are from E200 to E299, divided into sorbates (E200-209), benzoates (E210-219), sulfites (E220-229), phenols and formates (E230-239), nitrates (E240-259), acetates (E260-269), lactates (E270-279), propionates (E280-289) and others (E290-299).
An ammonium ion derivative resulting from the protonation of the nitrogen atom of a primary amino compound. Major species at pH 7.3.
Any compound that has anti-inflammatory effects.
An organic cation that is the conjugate acid of (R)-noradrenaline, obtained by protonation of the priamry amino group; major species at pH 7.3.
Any molecule that consists of at least one carbon atom as part of the electrically neutral entity.
A biomacromolecule composed of carbohydrate residues which is secreted by a microorganism into the surrounding environment.
A mancude heterobicyclic organic group consisting of a benzene ring fused to a pyrrole ring.
A bicyclic organic group that contains both carbon and hetero atoms.
Any metabolite produced during a metabolic reaction in eukaryotes, the taxon that include members of the fungi, plantae and animalia kingdoms.
Any eukaryotic metabolite produced during a metabolic reaction in animals that include diverse creatures from sponges, insects to mammals.
Any animal metabolite produced during a metabolic reaction in mammals.
Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae).
Saccharomyces cerevisiae secondary metabolites
Any metabolite produced during a metabolic reaction in prokaryotes, the taxon that include members of domains such as the bacteria and archaea.
Any metabolite produced by metabolism of a xenobiotic compound.
Any enzyme inhibitor that interferes with the action of a hydrolase (EC 3.*.*.*).
Any hydrolase inhibitor that interferes with the action of a hydrolase acting on C-N bonds, other than peptide bonds (EC 3.5.*.*).
EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitor
EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitors
EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitor
EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitors
EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitors
EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor
An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any non-peptide linear amide C-N hydrolase (EC 3.5.1.*).
EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitors
non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitor
non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitors
EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor
Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds.
Any human metabolite produced by metabolism of a xenobiotic compound in humans.
Any prokaryotic metabolite produced during a metabolic reaction in bacteria.
Any bacterial metabolite produced during a metabolic reaction in Escherichia coli.
Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of amidase (EC 3.5.1.4).
A food additive that is a (generally inert) gas which is used to envelop foodstuffs during packing and so protect them from unwanted chemical reactions such as food spoilage or oxidation during subsequent transport and storage. The term includes propellant gases, used to expel foods from a container.
A physiological role played by any substance that is distributed in foodstuffs. It includes materials derived from plants or animals, such as vitamins or minerals, as well as environmental contaminants.
A substance used in a thermodynamic heat pump cycle or refrigeration cycle that undergoes a phase change from a gas to a liquid and back. Refrigerants are used in air-conditioning systems and freezers or refrigerators and are assigned a "R" number (by ASHRAE - formerly the American Society of Heating, Refrigerating and Air Conditioning Engineers), which is determined systematically according to their molecular structure.
An amino acid-zwitterion obtained by transfer of a proton from the carboxy to the amino group of any alpha-amino acid; major species at pH 7.3.
Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula Cm(H2O)n; carbohydrate derivatives may contain other elements by substitution or condensation.
carbohydrates and carbohydrate derivatives
Any inorganic anion with a valency of two.
Any inorganic anion with a valency of one.
An animal metabolite produced by arthropods such as crabs, lobsters, crayfish, shrimps and krill.
A Daphnia metabolite produced by the species Daphnia magna.
A crustacean metabolite produced by the genus of small planktonic arthropods, Daphnia
Any member of the class of indoles carrying at least one hydroxy group.
A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane.
The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one).
Any fibroblast that is derived from the neural crest.
Any sensory receptor cell that is a(n) neuron and is capable of some detection of stimulus involved in sensory perception.
A cell found in the embryo before the formation of all the gem layers is complete.
Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination.
Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination.
A stem cell that is the precursor of gametes.
Female germ cell is a germ cell that supports female gamete production.
A stem cell that is the precursor of female gametes.
A female germ cell that has entered meiosis.
An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes.
A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization.
A smooth muscle cell derived from the neural crest.
Any neuron that develops from some migratory neural crest cell.
A non-terminally differentiated cell that develops form the neuroectoderm. Glioblast has the potential to differentiate into various types of glial cells, including astrocytes and oligodendrocytes.
A cell that will develop into a neuron often after a migration phase.
A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
This term applies to metazoan. For plant stem cells, consider using PO:0004011 ‘initial cell’ or its parent PO:0004010 ‘meristematic cell’.
A stem cell that self-renews as well as give rise to a single mature cell type.
A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119.
Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative.
A progenitor cell committed to the erythroid lineage.
A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring.
Originally this term had some plant germ line cell children.
A stem cell that can give rise to multiple lineages of cells.
A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages.
colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte
This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059).
A progenitor cell committed to the megakaryocyte and erythroid lineages.
colony forming unit erythroid megakaryocyte
MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2.
A oligopotent progenitor cell committed to the lymphoid lineage.
CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative.
A stem cell from which all cells of the body can form.
A precursor cell with a limited number of potential fates.
define using PATO mulit-potent or oligopotent?
A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair.
A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped.
These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative.
Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell.
A cell that has a filiform extrusion of the cell surface.
A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina.
An epithelial cell that is part of a duct.
An endothelial cell that lines the vasculature.
A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.
A flat, squamous-like epithelial cell of mesodermal origin. It forms the mesothelium, which lines the body's serous cavities including the pleural, peritoneal, and pericardial spaces. This cell plays a crucial role in synthesizing and secreting lubricants, such as glycosaminoglycans and surfactants, which minimize friction between adjacent tissues during movement.
Mesothelial cells, which morphologically resemble squamous epithelial cells, express both epithelial markers (cytokeratins) and mesenchymal markers (vimentin), reflecting their mesodermal origin. They feature surface microvilli and apical-basal polarity. Under certain conditions, they can undergo mesothelial-to-mesenchymal transition. These cells also produce extracellular matrix proteins, maintain serosal homeostasis, and facilitate fluid transport.
Any squamous epithelial cell that is part of some periderm.
A cell which moves among different tissues of the body, via blood, lymph, or other medium.
A cell found predominately in the blood.
A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells.
The term "neuroepithelial cell" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710).
Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions.
An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement.
Any neuron having a sensory function; an afferent neuron conveying sensory impulses.
A type of interneuron that has two neurites, usually an axon and a dendrite, extending from opposite poles of an ovoid cell body.
A neuron whose cell body is within an autonomic ganglion.
A neuron that uses acetylcholine as a vesicular neurotransmitter.
An ectodermal cell that is part of the external ectoderm, forming the outermost layer of the developing embryo. It is characterized by its polarized nature, with distinct apical and basal surfaces (Ferrante Jr., Reinke, & Stanley, 1995). Surface ectodermal cell gives rise to the epidermis, hair follicles, nails, sensory organs, and specialized structures like the apical ectodermal ridge crucial for limb development (Skoufa et al., 2024).
An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm.
From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard].
A neuron that has dendritic processes radiating from the cell body forming a star-like shape.
neuron associated cell (sensu Vertebrata)
A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons.
Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571
A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together.
A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system.
Oligodendrocytes are reportedly MDP-positive and CD4-negative.
An endothelial cell that lines the blood and lymphatic vessels of the digestive tract. This cell forms the gut–vascular barrier (GVB) through tight junctions and crosstalk with pericytes and enteric glial cells, regulating the passage of nutrients and immune cells while restricting microbial translocation into the bloodstream.
A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs.
Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2.
A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides.
Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell.
A pigment cell is a cell that contains pigment granules.
An epithelial cell, located in a gland, that is specialised for the synthesis and secretion of specific biomolecules, such as hormones, or mucous.
A cell that specializes in controlled release of one or more substances.
A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct.
A cell that secretes glycosaminoglycans.
Any secretory cell that is capable of some protein secretion.
A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions.
An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas.
A neuron that is capable of some hormone secretion in response to neuronal signals.
The neurosecretory cell is neither an ordinary neuron nor an endocrine cell, but a combination of both. Its neuronal features resemble those of ordinary neurons concerning both structure and function. The production of a visible secretory material marks the neurosecretory neuron as a gland cell, and the fact that extractable cellular products act in the manner of hormones places it in the realm of endocrine elements. The modern definition of neurosecretion has evolved to include the release of any neuronal secretory product from a neuron.
Any secretory cell that is capable of some peptide hormone secretion.
Any secretory cell that is capable of some somatostatin secretion.
Any secretory cell that is capable of some steroid hormone secretion.
A cell whose primary function is to shorten.
A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns.
A somatic cell located in skeletal muscle.
A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast).
A cell that is capable of detection of a stimulus involved in sensory perception.
A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood.
A specialized cell involved in gustatory sensory perception.
A cell specialized in detecting light stimuli that are involved in visual perception.
A cell whose function is determined by the generation or the reception of an electric signal.
A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons.
A cell that moves by its own activities.
A cell of the outer of the three germ layers of the embryo.
A cell of the middle germ layer of the embryo.
A cell of the inner of the three germ layers of the embryo.
Any cell that has characteristic some binucleate.
A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen.
Any photoreceptor cell that is part of some eye.
A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism.
A mature sexual reproductive cell having a single set of unpaired chromosomes.
An epithelial cell found in the trachea.
This class is for the vertebrate tracheal structure. For the analagous insect cell type, see 'respiratory tube epithelial cell'
Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid.
A cell that is specialised to accumulate a particular substance(s).
Any cell that is capable of some oxygen transport.
A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body.
A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors.
An early neural cell developing from the early ependymal cell of the neural tube.
A structural cell that is part of optic choroid.
Any cell that is part of some extraembryonic structure.
An extraembryonic cell that develops from a trophectodermal cell. This cell is found in the outer layer of the blastocyst and can invade other structures in the uterus once the blastocyst implants into the uterine wall. A trophoblast cell is involved in the implantation of the embryo into the uterine wall, placental formation, remodelling of maternal vasculature in the uterus, nutrient and gas exchange, hormone production, and immune modulation to support fetal development.
A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation.
An undifferentiated cell produced by early cleavages of the fertilized egg (zygote).
A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell.
Multi-potency demonstrated ex vivo. At the time of writing, it is unclear whether the endogenous population differentiates into multiple cell types in vivo.
A smooth muscle cell associated with the vasculature.
An epithelial cell of the integument (the outer layer of an organism).
Diploid cell produced by the fusion of sperm cell nucleus and egg cell.
A cell whose function is determined by its response to an electric signal.
Any interneuron that has its soma located in some ganglion.
A cell that initiates an electrical signal and passes that signal to another cell.
A cell that contains more than two haploid sets of chromosomes.
A cell whose nucleus contains a single haploid genome.
A muscle cell in which the fibers are organised into sarcomeres but in which adjacent myofibrils are offset from each other, producing an oblique banding pattern.
Examples include the somatic muscles of nemotodes and cephalopods.
A cell type that secretes 5-Hydroxytryptamine (serotonin).
A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme.
A photoreceptor cell that detects visible light.
A connective tissue cell of an organ found in the loose connective tissue.
A precursor cell destined to differentiate into cardiac muscle cell.
A precursor cell destined to differentiate into smooth muscle myocytes.
A myoblast that differentiates into skeletal muscle fibers.
A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy.
A neuron which conveys sensory information centrally from the periphery.
A neuron which sends impulses peripherally to activate muscles or secretory cells.
The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma.
A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.
Editors note: consider adding taxon constraint to vertebrata (PMID:18025161)
An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers.
A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers.
A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers.
The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated.
The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative).
Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative.
A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release.
Megakaryocytes are reportedly CD181-positive and CD182-positive.
An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds.
A mesenchymal stem cell capable of developing into blood vessel endothelium.
These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive.
A mesenchymal cell found in the developing heart and that develops into some part of the heart. These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field.
One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision.
The reproductive cell in multicellular organisms.
A steroid hormone secreting cell that secretes androgen.
Pyramidal neurons have a pyramid-shaped soma with a single axon, a large apical dendrite and multiple basal dendrites. The apex and an apical dendrite typically point toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their region. Pyramidal neurons are found in the cerebral cortex, the hippocampus, and the amygdala.
One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision.
A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus).
A cell whose primary function is to support other cell types.
An endothelial cell that has small pores, or fenestrations, which allow for the efficient exchange of substances between the blood and surrounding tissues.
An extracellular matrix secreting cell that secretes collagen.
A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells.
A mature sexual reproductive cell of the female germline.
A non-terminally differentiated cell that is capable of developing into a muscle cell.
Any interneuron that has characteristic some stellate morphology.
An interneuron that has spider-like appearance with a small round soma, a large number (7-10) of short, smooth, or slightly beaded primary dendrites that give rise to only a few secondary branches, and a branched axon that establishes a dense axonal mesh with thin shafts.
A cell that stores and secretes pancreatic polypeptide hormone.
Epithelial cells derived from neural plate and neural crest.
The term "neuroepithelial cell" is used to describe both this cell type and sensory epithelial cell (CL:0000098).
A stem cell that can give rise to cell types of the body other than those of the germ-line.
Muscle cell which has as its direct parts myofilaments organized into sarcomeres.
An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.
The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve.
Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei.
This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods. The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein). According to these refs, the cells participating in heart contraction in all cases are transversely striated. Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction.
A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage.
A immature or mature cell in the lineage leading to and including erythrocytes.
Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes.
A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers.
A cell of the monocyte, granulocyte, or mast cell lineage.
A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans.
hematopoietic multipotent progenitor cell
A progenitor cell restricted to the lymphoid lineage.
Note that this is a class of cell types, not an identified single cell type.
lymphoid lineage restricted progenitor cell
A progenitor cell restricted to the myeloid lineage.
myeloid lineage restricted progenitor cell
A leukocyte with a single non-segmented nucleus in the mature form.
A neuron that releases serotonin as a neurotransmitter.
A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers.
hematopoietic oligopotent progenitor cell, lineage-negative
A cell found in an organism or derived from an organism exhibiting a phenotype that deviates from the expected phenotype of any native cell type of that organism. Abnormal cells are typically found in disease states or disease models.
An abnormal cell exhibiting dysregulation of cell proliferation or programmed cell death and capable of forming a neoplasm, an aggregate of cells in the form of a tumor mass or an excess number of abnormal cells (liquid tumor) within an organism.
A neoplastic cell that is capable of entering a surrounding tissue
A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative).
A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells.
hematopoietic lineage restricted progenitor cell
A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities.
This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060).
hematopoietic oligopotent progenitor cell
An enteroendocrine cell that produces glucagon.
Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter.
A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery.
Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes.
The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides).
An epithelial cell derived from endoderm.
An epithelial cell derived from ectoderm.
Epithelial cell derived from mesoderm or mesenchyme.
A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart.
A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells.
MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense.
A cell in the hilum of the ovary that produces androgens.
An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels.
cubodial endothelial cell of vascular tree
These cells are reportedly CD31-positive, CD34-positive, CD144-positive, TAL1-positive.
An endothelial cell found in capillaries.
A multi-ciliated epithelial cell located in the trachea and bronchi, characterized by a columnar shape and motile cilia on its apical surface. These cilia facilitate mucociliary clearance by moving mucus and trapped particles toward the pharynx.
ciliated columnar cell of tracheobronchial tree
The marker set C1orf194, MS4A8 can identify the Human cell type ciliated columnar cell of tracheobronchial tree in the Lung with a confidence of 0.86 (NS-Forest FBeta value).
These cells possess numerous cilia on their surface, typically ranging from 200 to 300 per cell. The cilia vary in length, measuring between 6 to 7 μm in the upper airways (trachea) and becoming shorter, around 4 μm, in the smaller airways (terminal bronchioles). These cells form a two-layered 'coat' in the airway: the lower 'sol' layer is watery, allowing the cilia to beat in coordinated waves, while the upper 'gel' layer is thick and sticky, trapping inhaled particles.
multiciliated columnar cell of tracheobronchial tree
Epithelial cells derived from general body ectoderm and ectoderm placodes.
An epithelial cell found in the lining of the stomach.
A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit.
An epithelial cell of the tracheobronchial tree.
epithelial cell of tracheobronchial tree
An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells.
undifferentiated columnar cell of tracheobronchial tree
A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye.
A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth.
A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells).
An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus.
An epithelial cell of the lining of the esophagus.
An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver.
A type of enteroendocrine cell found in the stomach that secretes glucagon.
A cell that is part of the nervous system.
A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone.
A multi-ciliated epithelial cell located in the bronchus epithelium, characterized by a columnar shape and motile cilia on its apical surface.
ciliated epithelial cell of the bronchus
multiciliated epithelial cell of the bronchus
An adipocyte derived from a neural crest cell.
An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin.
A hematopoietic stem cell that exists during embryogenesis.
A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic morphology; located between the lamellae with a large flattened nucleus, and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratan sulfate.
An epithelial cell of the respiratory tract epithelium. These cells have an endodermal origin.
A transversely striated, multinucleated syncytial muscle cell, formed by the fusion of myoblasts during muscle development.
A multipotent progenitor cell that develops from a migratory neural crest cell. The schwann cell precursor is embedded among axons, with minimal extracellular space separating them from nerve cell membranes. This cell lacks a basal lamina, which distinguishes it from more mature Schwann cells. In rodents, cadherin-19 (Cdh19) serves as a specific marker for this developmental stage.
Schwann cell precursor are capable of differentiating into Schwann cells and other cell types such as melanocytes, neurons, and mesenchymal cells.
A glial cell that develops from a Schwann cell precursor. The immature Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. Immature Schwann cell can be found communally ensheathing large groups of axons.
A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles.
A reticulocyte lacking a nucleus and showing a basophilic reticulum under vital staining due to the presence of ribosomes.
A progenitor cell of the central nervous system that can differentiate into oligodendrocytes or type-2 astrocytes. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons.
oligodendrocyte-type 2 astrocyte (O-2A) progenitor cell
oligodendrocyte/type-2 astrocyte progenitor cell
A cell located in the heart, including both muscle and non muscle cells.
From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart.
A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc
An adipocyte that is part of subcutaneous adipose tissue.
A mesenchymal stem cell that is part of the bone marrow.
mesenchymal stem cell of the bone marrow
An endothelial cell that is part of the vein.
Any skin fibroblast that is part of some dermis.
A mesenchymal stem cell of adipose tissue.
A glial cell that myelinates or ensheathes axons in the peripheral nervous system.
A myelinating Schwann cell wraps around a single axon. Myelination occurs in larger diameter axons, while a process called ensheathment occurs on smaller diameter axons in which a single cell wraps around multiple small, unmyelinated axons separating them with a thin layer of cytoplasm. The structure formed is called a Remak bundle.
A blood vessel endothelial cell that is part of the retina.
A smooth muscle cell of the bachiocephalic vasculature.
smooth muscle cell of the brachiocephalic vasculature
A vascular associated smooth muscle cell of the brain vasculature.
smooth muscle cell of the brain vasculature
A smooth muscle of the pulmonary artery.
smooth muscle cell of the pulmonary artery
A smooth muscle cell of the subclavian artery.
smooth muscle cell of the subclavian artery
Smooth muscle cell of the carotid artery.
Any smooth muscle cell that is part of some bronchus.
Any epithelial cell that is part of some lower respiratory tract epithelium.
epithelial cell of lower respiratory tract
A glandular epithelial cell of the esophagus.
A glandular epithelial cell that is part of the stomach.
A myocardial endocrine cell that is part of the atrium.
A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart.
Discrepancy in develops from origins prevents me from making the assertion that cardioblasts give rise to all instances of cardiocytes as we state cardiac muscle cells develop from cardiac myoblast, which in turn develop from muscle stem cell.
A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells.
A skeletal muscle cell that is part of the tongue.
A neuroblast derived from a neural crest cell.
A retinal ganglion cell that has dendrites stratified in two layers of the inner-plexiform layer.
A central nervous system neuron that stratifies at one and only one location.
A neuron that stratifies dendrites at two and only two locations.
A CNS interneuron located in the spinal cord.
Is_a interneuron, part_of UBERON:0002240.
A columnar/cuboidal epithelial cell with multiple motile cilia on its apical surface. These cells facilitate the movement of liquids such as mucus or cerebrospinal fluid across the epithelial surface.
multi-ciliated cell
multiciliated cell
multiciliated epithelial cell
While the term 'multi-ciliated epithelial cell' refers to cells with multiple motile cilia, there are exceptions where epithelial cells may have multiple non-motile cilia. Examples include olfactory sensory neurons, which have non-motile cilia for sensory detection, and choroid plexus epithelial cells, which possess multiple non-motile cilia with transient motility during development. Multiciliated cells are essential for human health, and their dysfunction can lead to various diseases known as ciliopathies, such as primary ciliary dyskinesia. This condition affects the respiratory system, brain ventricles, and reproductive system, leading to chronic respiratory infections, hydrocephalus, and infertility
A motor neuron that innervates a skeletal muscle. These motor neurons are all excitatory and cholinergic.
somatomotor neuron
Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized).
Needs logical definition. Should be capable_of skeletal system morphogenesis? or skeletal tissue development? needs to be added to GO. NOTES:a cell type of the early embryo (see also: mesenchymal cells) that will give rise to mineralized connective tissue. Scleroblasts can differentiate into osteoblasts (bone-forming cells), chondroblasts (cartilage-forming cells), odontoblasts (dentin-forming cells), ameloblasts (enamel-forming cells). The mesenchymal cells developing into osteoblasts and chondroblasts are derived from the mesoderm. Those developing into odontoblasts are neural crest cells. Those developing into ameloblasts are derived from the ectoderm. (http://www.copewithcytokines.de/cope.cgi?key=scleroblasts)
Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells.
Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells.
Any muscle cell in which the fibers are not organised into sarcomeres.
Any hematopoietic cell that is a precursor of some other hematopoietic cell type.
A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
skeletal muscle fiber
A muscle cell that is part of some visceral muscle.
visceral muscle cell
A visceral muscle cell that is striated. Examples include the visceral muscle cells of arhtropods.
striated visceral muscle cell
A visceral muscle that is transversely striated. Examples include the visceral muscle cells of arthropods.
transversely striated visceral muscle cell
A skeletal muscle myoblast that is part of a skeletal mucle. These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers.
The vast majority of these cells develop from skeletal muscle satellite cells, although there are some reports of other origins.
A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration.
A mesenchymal cell of the endocardial cushion. These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves.
A neuron that release noradrenaline (noriphinephrine) as a neurotransmitter.
Any neuron that is capable of part of some visual perception.
An interneuron that has its soma located in the cerebral cortex.
cortical interneuron
Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation.
mural cell
Any vascular associated smooth muscle cell that is part of some microcirculatory vessel.
microcirculation associated smooth muscle cell
A secretory epithelial cell of the respiratory tract epithelium. These cells have an endodermal origin.
respiratory tract secretory epithelial cell
A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord.
Any cell in the compound eye, a light sensing organ composed of ommatidia.
Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
A skeletal muscle fiber found in an embryo. In mammalian embryos, skeletal muscle expresses myosin heavy chain-embryonic (MyHC-emb, encoded by the MYH3 gene), which regulates skeletal muscle development.
A stromal cell that is part_of a bone marrow.
A mononuclear cell that is part_of a bone marrow.
Any blood vessel endothelial cell that is part of some heart.
Any cell that is part of some His-Purkinje system.
Any endothelial cell that is part of some heart.
Any photoreceptor cell that is part of some camera-type eye.
zygote
Any glial cell that is part of some heart.
Any myoblast that develops into some cardiac muscle cell.
A neuron that has its soma in the heart.
This term is used in 3 GO terms that were created as part of the heart development focus project.
A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement.
A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites.
A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells.
A mesothelial cell that is part of the epicardium.
A fibroblast that is part of upper back skin.
A fibroblast that is part of skin of back.
A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses.
Any fibroblast that is part of skeletal muscle tissue.
Any microvascular endothelial cell that is part of the dermis.
A cell that, by division or terminal differentiation, can give rise to other cell types.
Work is needed on GO 'cell differentiation' before it is clear whether the equivalent class definition 'native cell' that capable_of some 'cell differentiation' works. Also, may want to consider merging this with non-terminally differentiated cell.
Cytoplasm that exhibits a characteristic staining and color, pale-pink, with Wright-Giemsa stain.
Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain.
Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions.
Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions.
A concave nucleus shape where the indentation is smaller than half of the distance to the farthest nuclear margin.
Any nucleus that has characteristic some alobate.
alobate nucleus
Any serous secreting cell that is part of the tracheobronchial epithelium.
tracheobronchial serous cell
Any chondrocyte that is part of the tracheobronchial tree.
tracheobronchial chondrocyte
A smooth muscle cell that is part of any blood vessel.
blood vessel smooth muscle cell
A smooth muscle cell that is part of the tracheobronchial tree.
smooth muscle cell of tracheobronchial tree
The marker set ACTA2, TAGLN can identify the Human cell type tracheobronchial smooth muscle cell in the Lung with a confidence of 0.69 (NS-Forest FBeta value).
tracheobronchial smooth muscle cell
Any neuroblast (sensu Vertebrata) that is part of some forebrain.
A specialised neuroendocrine cell located in the gastric mucosa that regulates digestive processes including acid secretion and gut motility. This cell stores hormones in large dense core vesicles and synaptic-like microvesicles.
A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Pulmonary neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Pulmonary neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury.
The marker set CHGA, GRP can identify the Human cell type lung neuroendocrine cell in the Lung with a confidence of 0.94 (NS-Forest FBeta value).
An epithelial cell that is part of the lung epithelium. This cell is characterised by the presence of cilia on its apical surface.
Any secretory cell that is part of some lung.
An extraembryonic cell that is part of the trophectoderm, representing the first lineage to differentiate in the embryo. This cell is crucial for implantation into the uterine wall and differentiates into trophoblast cells, which contribute to placenta formation and facilitate maternal-fetal nutrient and signal exchange.
A mesothelial cell that is part of the dura mater.
A fibroblast that is part of the areolar connective tissue.
A fibroblast that is part of the tunica adventitia of artery.
fibroblast of tunica adventitia of artery
A fibroblast that is part of the dense regular elastic tissue.
fibroblast of dense regular elastic tissue
An adipocyte that is part of the epicardial fat.
An adipocyte that is part of the epicardial fat of right ventricle.
adipocyte of epicardial fat of right ventricle
An adipocyte that is part of the epicardial fat of left ventricle.
adipocyte of epicardial fat of left ventricle
A serous secreting cell that is part of the epithelium of trachea.
A serous secreting cell that is part of the epithelium of bronchus.
A transitional myocyte that is part of the interatrial septum.
transitional myocyte of interatrial septum
A transitional myocyte that is part of the interventricular septum.
transitional myocyte of interventricular septum
A Purkinje myocyte that is part of the interventricular septum.
Purkinje myocyte of interventricular septum
A muscle cell that is part of the sinoatrial node.
A muscle cell that is part of the atrioventricular node.
An endothelial cell that is part of the arteriole.
A blood vessel endothelial cell that is part of an arterial endothelium.
An endothelial cell that is part of the venule.
A somatic stem cell that is part of the epidermis.
A smooth muscle cell that is part of the ciliary body.
A mesothelial cell that is part of the anterior chamber of eyeball.
mesothelial cell of anterior chamber of eye
A mesothelial cell that is part of the parietal peritoneum.
A mesothelial cell that is part of the visceral peritoneum.
A transitional myocyte that is part of the sinoatrial node.
A Purkinje myocyte that is part of the atrioventricular node.
Purkinje myocyte of atrioventricular node
A myocardial endocrine cell that is part of the interventricular septum.
myocardial endocrine cell of interventricular septum
A mesothelial cell that is part of the peritoneum.
A mesothelial cell that is part of the pleura.
A mesothelial cell that is part of the parietal pleura.
A mesothelial cell that is part of the visceral pleura.
The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the stomach.
Any endothelial cell of vascular tree that is part of some lung.
Any endothelial cell of vascular tree that is part of some pulmonary artery.
oral cavity mucosa squamous epithelial cell
A distinct endothelial cell forming the walls of the capillaries within the cerebral cortex.
Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes.
An epithelial cell that is specialised for the synthesis and secretion of specific biomolecules.
secretory epithelial cell
A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood.
Any macroglial cell that is part of a brain.
Any blood vessel endothelial cell that is part of a microvascular endothelium.
Any blood vessel endothelial cell that is part of a dermis.
Any skin fibroblast that is part of a skin of abdomen.
Any lung endothelial cell that is part of a microvascular endothelium.
Any photoreceptor cell that is part of a compound eye.
Any native cell that is part of a inner cell mass.
Any native cell that is part of a cardiac septum.
Any oligodendrocyte that is part of a spinal cord.
Any neuron that is part of a central nervous system.
A neuron that is part of a peripheral nervous system.
Any fibroblast that is part of a embryo.
Any microvascular endothelial cell that is part of a brain.
Any cardiac muscle cell that is part of a cardiac ventricle.
Any motor neuron that is part of a brainstem.
Any fibroblast that is part of a female gonad.
Any fibroblast that is part of a cardiac ventricle.
Any fibroblast that is part of a cardiac atrium.
Any fibroblast that is part of a pericardium.
Any fibroblast that is part of a optic choroid.
Any microvascular endothelial cell that is part of a adipose tissue.
Any migratory neural crest cell that is part of a cardiac neural crest.
Any mesenchymal stem cell of adipose tissue that is part of an abdomen.
mesenchymal stem cell of abdominal adipose
mesenchymal stem cell of abdominal adipose tissue
Any fibroblast of lung that is part of a bronchus.
A neuron type that is located in a peripheral nervous system and it transmits sensory information from the peripheral (PNS) to the central nervous system (CNS). A sensory neuron converts physical (light, sound, touch) or chemical (such as taste and smell) stimuli into an electrical signal through a process known as sensory transduction. The function of a sensory neuron is to carry informations from the external environment and internal body conditions to the central nervous system for further processing.
Typically, a sensory neuron has a pseudounipolar morphology.
A pyramidal neuron which has an apical tree which is oriented parallel to the pia. This is unlike typical pyramidal neurons which have its apical dendrite aligned vertically.
A cell that is part of the brain vasculature.
A type of interneuron that has two clusters of dendritic branches that originate directly from the soma and extend in opposite directions and axons that form a plexus which spreads widely. Compared to bipolar neurons, bitufted neurons have branching that occur close to the soma.
A GABAergic inhibitory neuron that is derived from the midbrain.
A pyramidal neuron which has an apical tree which is oriented towards the white matter.
A pyramidal neuron which lacks a tuft formation but extends small radial distances forming a star-like shape.
A pyramidal neuron which has a distinctive tuft formation, distal from the soma.
A pyramidal neuron which lacks a clear tuft formation but extends to large radial distances.
A pyramidal neuron with soma located in the cerebral cortex.
A glial cell that myelinates axonal processes.
An interneuron that has double bouquet morphology.
A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli.
Any capillary endothelial cell that is part of a lung.
A multiciliated epithelial cell located in the respiratory tract epithelium, characterized by a columnar shape and motile cilia on its apical surface. This cell develops through a highly orchestrated process, transitioning from a basal progenitor via an intermediate deuterosomal cell stage that generates centrioles essential for ciliogenesis.
A(n) vein endothelial cell that is part of a(n) respiratory system.
vein endothelial cell of respiratory system
A megakaryocyte that is resident in the lung connective tissue.
An epithelial cell part of respiratory tract epithelium that is a precursor of a multi-ciliated cell. This cell actively amplifies centrioles, a required step for multiciliogenesis.
In humans, deuterosomal cells have been noted to have enriched expression of the following: PLK4, FOXJ1, DEUP1, FOXN4, YPEL1, HES6 and CDC20B. Deuterosomal cells were termed after deuterosomes, the platforms of active centriole amplification.
A taste receptor cell that is part of a taste bud of a tongue.
A neuron that releases catecholamine as a neurotransmitter.
Frequently used when describing the developing nervous system in zebrafish. A catecholaminergic neuron expresses tyrosine hydroxylase (TH), tyrosine hydroxylase 2 (TH2), aromatic amino acid decarboxylase (AADC), dopamine b-hydroxylase (DBH), and phenylethanolamine-N-methyl transferase (PEMT), which are enzymes necessary for catecholamine synthesis.
A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics.
A stem cell that is part of the corneo-scleral limbus. This cell type resides at the basal layer of the epithelium and has a small size and high nuclear to cytoplasmatic ratio (Secker and Daniels, 2009). A limbal stem cell is responsible for corneal epithelial renewal and repair (Li et al., 2023), and to help maintain a clear corneal surface by preventing conjunctival epithelial cells from migrating onto the cornea (Wang et al., 2023).
Any mesenchymal stem cell of adipose tissue that is part of an orbital region.
orbital adipose-derived mesenchymal stem cell
mesenchymal stem cell of orbital adipose tissue
A(n) neuroblast (sensu Vertebrata) that is cycling.
proliferating neuroblast (sensu Vertebrata)
A fibroblast located in the lamina propria of the intestinal mucosa. This cell expresses PDGFRα and CD81 and is negative for α-smooth muscle actin (α-SMA). This cell is predominantly located in the small intestine adjacent to myofibroblasts surrounding the crypts. It is capable of synthesizing extracellular matrix components and structural proteins such as collagen and elastin.
intestinal lamina propria fibroblast
A multinucleate cell formed by the fusion of multiple uninuclear cells through plasma membrane fusion. This process leads to a single large cell containing multiple nuclei within a shared cytoplasm.
Any capillary endothelial cell that is part of an endocrine gland.
endocrine gland capillary endothelial cell
A fibroblast of the adventitia of a blood vessel. This cell contributes to vascular homeostasis, remodeling, and inflammation by producing extracellular matrix components, cytokines, and growth factors. Adventitial fibroblast can transition into an activated state during injury or disease, marked by increased proliferation, migration, matrix deposition, and contractile protein expression
Single-cell transcriptomics of murine aorta identifies two adventitial fibroblast-specific markers, PDGFRA and DPEP1, which were validated at the protein level by immunohistochemistry and flow cytometry across human and murine arteries, highlighting fibroblast heterogeneity in health and cardiovascular disease (CVD) in humans and mice.
A stromal cell that is part of the ovarian stroma, characterized by its ability to synthesize steroid hormones.
The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton.
The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
mitotic sister-chromatid adhesion release
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
microtubule cytoskeleton organization and biogenesis
A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.
The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle.
The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.
A ribosome contained within a subcellular membrane-bounded organelle.
The joining of 2 or more lipid bilayer membranes that surround the nucleus.
The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei.
The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.
syncytium formation by plasma membrane fusion
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore.
A compact and highly condensed form of chromatin that is refractory to transcription.
The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets.
The developmental process in which the size or shape of a cell is generated and organized.
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.
This term should be used to describe a response to a specific acid as a chemical. E.g., if an organism were responding to glutamate, then the response would be glutamate-specific; the organism is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0010447 'response to acidic pH' instead.
The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'.
A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities.
Action potentials typically propagate across excitable membranes. This class covers both action potentials that propagate and those that fail to do so.
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella.
ciliary or bacterial-type flagellar motility
Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent, while the bacterial- and archaeal-type flagella have a different structure. The former are microtubule-based structures that lash back and forth and are present only in eukaryotes, while the latter achieve motility by rotation. Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. These three structures never co-exist in the same organism. Therefore, GO:0001539 'cilium or flagellum-dependent cell motility' is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term. Direct annotations to GO:0001539 'cilium or flagellum-dependent cell motility' may be amended during annotation QC.
cilium or flagellum-dependent cell motility
The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization.
Any process that modulates the frequency, rate, extent or direction of cell growth.
Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time.
interpretation of external signals that regulate cell growth
regulation of cell growth by detection of exogenous stimulus
regulation of cell growth by sensing of exogenous stimulus
regulation of growth by exogenous signal
regulation of growth by exogenous stimuli
regulation of growth by exogenous stimulus
regulation of growth by external stimuli
regulation of growth by external stimulus
regulation of cell growth by extracellular stimulus
The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system.
branching involved in blood vessel morphogenesis
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
A process that results in a parallel arrangement of microtubules.
The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.
A homeostatic process in which an organism modulates its internal body temperature.
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%.
Cell migration that is accomplished by extension and retraction of a pseudopodium.
Note that this term refers to a mode of migration rather than to any particular cell type.
The nucleus of the female germ cell, a reproductive cell in females.
Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator).
translation initiation ternary complex assembly
formation of translation initiation ternary complex
The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.
The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster.
embryonic development via the syncytial blastoderm
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
The formation of the ectoderm, mesoderm and endoderm during gastrulation.
The formation of ectoderm during gastrulation.
The formation of the endoderm during gastrulation.
The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.
The initial developmental process that will lead to the formation of an eye.
The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell.
compound eye photoreceptor cell differentiation
The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms.
The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes.
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell.
A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell.
The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus.
Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus.
The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
Any process that modulates the frequency, rate, or extent of production of a cytokine.
regulation of cytokine biosynthetic process
Any process that stops, prevents, or reduces the rate of production of a cytokine.
down regulation of cytokine biosynthetic process
down-regulation of cytokine biosynthetic process
downregulation of cytokine biosynthetic process
negative regulation of cytokine anabolism
negative regulation of cytokine biosynthesis
negative regulation of cytokine formation
negative regulation of cytokine synthesis
inhibition of cytokine biosynthetic process
negative regulation of cytokine biosynthetic process
negative regulation of cytokine secretion
negative regulation of cytokine production
Any process that activates or increases the frequency, rate or extent of production of a cytokine.
positive regulation of cytokine biosynthetic process
positive regulation of cytokine secretion
positive regulation of cytokine production
The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesized in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells.
The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. The blastula follows the morula and precedes the gastrula in the developmental sequence.
See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'.
The initial formation of a blastocyst from a solid ball of cells known as a morula.
See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'.
The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell.
See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'.
The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell.
See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'.
The morphogenesis of trophectoderm cells.
See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'.
An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation.
See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'.
The proliferation of cells in the inner cell mass.
See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'.
The proliferation of cells in the trophectoderm.
A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
mesenchymal cell differentiation from epithelial cell
Epithelial-Mesenchymal Transition (EMT) during gastrulation
The morphogenesis of an embryonic epithelium into a tube-shaped structure.
The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue.
The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.
The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.
The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove.
The progression of an endothelial cell over time, from its formation to the mature structure.
The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell.
The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.
Any process that modulates the frequency, rate, or extent of endothelial cell proliferation.
regulation of endothelial cell proliferation
Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.
down regulation of endothelial cell proliferation
down-regulation of endothelial cell proliferation
downregulation of endothelial cell proliferation
inhibition of endothelial cell proliferation
negative regulation of endothelial cell proliferation
Any process that activates or increases the rate or extent of endothelial cell proliferation.
up regulation of endothelial cell proliferation
up-regulation of endothelial cell proliferation
upregulation of endothelial cell proliferation
activation of endothelial cell proliferation
stimulation of endothelial cell proliferation
positive regulation of endothelial cell proliferation
The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.
A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state.
Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter.
up regulation of neurotransmitter secretion
up-regulation of neurotransmitter secretion
upregulation of neurotransmitter secretion
activation of neurotransmitter secretion
stimulation of neurotransmitter secretion
positive regulation of neurotransmitter secretion
Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells.
An instance of intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division.
The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.
The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells.
Any process that modulates the frequency or rate of heart contraction.
Any process that activates or increases the rate of neuroblast proliferation.
up regulation of neuroblast proliferation
up-regulation of neuroblast proliferation
upregulation of neuroblast proliferation
positive regulation of neuroblast proliferation
The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells.
up regulation of mesenchymal cell proliferation
up-regulation of mesenchymal cell proliferation
upregulation of mesenchymal cell proliferation
activation of mesenchymal cell proliferation
stimulation of mesenchymal cell proliferation
positive regulation of mesenchymal cell proliferation
The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage.
The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.
The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.
The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.
columnar/cuboidal epithelial cell differentiation
The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.
columnar/cuboidal epithelial cell development
The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.
glandular epithelial cell differentiation
The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.
The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.
columnar/cuboidal epithelial cell maturation
The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.
The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.
The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus.
optic cup morphogenesis involved in camera-style eye development
optic cup morphogenesis involved in camera-type eye development
Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells.
negative regulation of neural plate formation
repression of premature neural plate formation
inhibition of neuroepithelial cell differentiation
A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates.
regulation of respiratory gaseous exchange by neurological system process
regulation of respiratory gaseous exchange by nervous system process
The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
Note that this term applies to translation performed by cytoplasmic ribosomes, which is distinct from translation performed by organellar ribosomes. For mitochondrial translation, consider GO:0032543 'mitochondrial translation' or its child terms.
The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm.
The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon.
A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism.
physiological defense response to insect
The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.
haematopoietic progenitor cell differentiation
haemopoietic progenitor cell differentiation
hemopoietic progenitor cell differentiation
hematopoietic progenitor cell differentiation
Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation.
The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus.
The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response.
immune cell activation during inflammatory response
leukocyte activation during inflammatory response
leukocyte activation involved in inflammatory response
A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand.
The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages.
The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages.
lymphoid progenitor cell differentiation
The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
serotonin production involved in acute inflammatory response
serotonin production involved in inflammatory response
Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501).
The regulated release of serotonin by a cell as part of an inflammatory response.
serotonin secretion involved in acute inflammatory response
serotonin release involved in inflammatory response
serotonin secretion involved in inflammatory response
Any process involved in the carrying out of an immune response by a leukocyte.
Any process involved in the carrying out of an immune response by a myeloid leukocyte.
myeloid leucocyte immune effector process
myeloid leukocyte immune effector process
Any process involved in the carrying out of an immune response by a lymphocyte.
The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.
The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response.
immune cell migration during inflammatory response
immune cell trafficking during inflammatory response
leucocyte migration during inflammatory response
leucocyte trafficking during inflammatory response
leukocyte migration during inflammatory response
leukocyte trafficking during inflammatory response
leukocyte migration involved in inflammatory response
The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels.
production of molecular mediator involved in acute inflammatory response
production of cellular mediator of acute inflammation
production of molecular mediator involved in inflammatory response
The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
cytokine production involved in acute inflammatory response
cytokine production involved in inflammatory response
The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage.
Any process that modulates the frequency, rate, or extent of an immune system process.
Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process.
down regulation of immune system process
down-regulation of immune system process
negative regulation of immune system process
Any process that activates or increases the frequency, rate, or extent of an immune system process.
positive regulation of immune system process
Any process that modulates the frequency, rate, or extent of leukocyte migration.
Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration.
negative regulation of immune cell migration
negative regulation of leucocyte migration
negative regulation of leukocyte migration
Any process that activates or increases the frequency, rate, or extent of leukocyte migration.
positive regulation of immune cell migration
positive regulation of leucocyte migration
positive regulation of leukocyte migration
Any process that modulates the frequency, rate, or extent of leukocyte activation.
Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation.
negative regulation of immune cell activation
negative regulation of leucocyte activation
negative regulation of leukocyte activation
Any process that activates or increases the frequency, rate, or extent of leukocyte activation.
positive regulation of immune cell activation
positive regulation of leucocyte activation
positive regulation of leukocyte activation
Any process that modulates the frequency, rate, or extent of an immune effector process.
Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process.
down regulation of immune effector process
down-regulation of immune effector process
downregulation of immune effector process
negative regulation of immune effector process
Any process that activates or increases the frequency, rate, or extent of an immune effector process.
up regulation of immune effector process
up-regulation of immune effector process
positive regulation of immune effector process
Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity.
regulation of immune cell mediated immunity
regulation of leucocyte mediated immunity
regulation of leukocyte mediated immunity
Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity.
down regulation of leukocyte mediated immunity
down-regulation of leukocyte mediated immunity
downregulation of leukocyte mediated immunity
negative regulation of immune cell mediated immunity
negative regulation of leucocyte mediated immunity
inhibition of leukocyte mediated immunity
negative regulation of leukocyte mediated immunity
Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity.
positive regulation of immune cell mediated immunity
positive regulation of leucocyte mediated immunity
up regulation of leukocyte mediated immunity
up-regulation of leukocyte mediated immunity
upregulation of leukocyte mediated immunity
activation of leukocyte mediated immunity
stimulation of leukocyte mediated immunity
positive regulation of leukocyte mediated immunity
Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity.
regulation of lymphocyte mediated immunity
Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity.
down regulation of lymphocyte mediated immunity
down-regulation of lymphocyte mediated immunity
downregulation of lymphocyte mediated immunity
inhibition of lymphocyte mediated immunity
negative regulation of lymphocyte mediated immunity
Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity.
up regulation of lymphocyte mediated immunity
up-regulation of lymphocyte mediated immunity
upregulation of lymphocyte mediated immunity
activation of lymphocyte mediated immunity
stimulation of lymphocyte mediated immunity
positive regulation of lymphocyte mediated immunity
Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation.
regulation of myeloid leukocyte differentiation
Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation.
down regulation of myeloid leukocyte differentiation
down-regulation of myeloid leukocyte differentiation
downregulation of myeloid leukocyte differentiation
inhibition of myeloid leukocyte differentiation
negative regulation of myeloid leukocyte differentiation
Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation.
up regulation of myeloid leukocyte differentiation
up-regulation of myeloid leukocyte differentiation
upregulation of myeloid leukocyte differentiation
activation of myeloid leukocyte differentiation
stimulation of myeloid leukocyte differentiation
positive regulation of myeloid leukocyte differentiation
The controlled release of a peptide from a cell or a tissue.
Any process that modulates the frequency, rate, or extent of peptide secretion.
Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion.
negative regulation of peptide secretion
Any process that activates or increases the frequency, rate, or extent of peptide secretion.
positive regulation of peptide secretion
Any process that modulates the frequency, rate, or extent of a response to biotic stimulus.
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
regulation of response to biotic stimulus
Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus.
down regulation of response to biotic stimulus
down-regulation of response to biotic stimulus
downregulation of response to biotic stimulus
inhibition of response to biotic stimulus
negative regulation of response to biotic stimulus
Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus.
up regulation of response to biotic stimulus
up-regulation of response to biotic stimulus
upregulation of response to biotic stimulus
activation of response to biotic stimulus
stimulation of response to biotic stimulus
positive regulation of response to biotic stimulus
Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity.
regulation of myeloid leukocyte mediated immunity
Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity.
down regulation of myeloid leukocyte mediated immunity
down-regulation of myeloid leukocyte mediated immunity
downregulation of myeloid leukocyte mediated immunity
inhibition of myeloid leukocyte mediated immunity
negative regulation of myeloid leukocyte mediated immunity
Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity.
up regulation of myeloid leukocyte mediated immunity
up-regulation of myeloid leukocyte mediated immunity
upregulation of myeloid leukocyte mediated immunity
activation of myeloid leukocyte mediated immunity
stimulation of myeloid leukocyte mediated immunity
positive regulation of myeloid leukocyte mediated immunity
The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move.
The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.
A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring.
developmental process involved in reproduction
The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.
A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control.
An organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.
An organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.
A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange.
The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal.
Any process that mediates the transfer of information from mesodermal cells to endodermal cells.
Any process that mediates the transfer of information from endodermal cells to mesodermal cells.
The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field.
The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.
The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.
The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis.
embryonic heart tube formation via epithelial folding
The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation.
neural crest cell migration involved in heart formation
The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract.
The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum.
The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum.
The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.
The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation.
morphogenesis of an epithelial fold involved in embryonic heart tube formation
Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment.
The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.
The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.
The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.
The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.
The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat.
cardiac impulse conducting system development
The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system.
The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node.
The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles.
The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle.
The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle.
cardiac Purkinje fiber cell differentiation
The process in which the anatomical structures of veins of the heart are generated and organized.
The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.
The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.
The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart.
The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart.
The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.
The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart.
The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.
The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.
The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.
The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.
The process in which the left cardiac atrium is generated and organized.
The process in which the right cardiac atrium is generated and organized.
The process in which the left cardiac ventricle is generated and organized.
The process in which the right cardiac ventricle is generated and organized.
The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts.
The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts.
The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts.
The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts.
The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized.
left ventricular myocardium morphogenesis
left ventricular cardiac muscle tissue morphogenesis
The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized.
right ventricle myocardium morphogenesis
right ventricular cardiac muscle tissue morphogenesis
The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure.
atrial cardiac muscle tissue development
The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure.
ventricular cardiac muscle tissue development
The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.
The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.
The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart.
The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart.
The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart.
Developmental growth that contributes to the shaping of the heart.
The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart.
cardiac muscle tissue growth involved in heart morphogenesis
The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle.
The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract.
cardiac neural crest cell migration involved in outflow tract morphogenesis
The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.
The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.
cell migration involved in endocardial cushion formation
Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries.
apoptosis involved in outflow tract morphogenesis
apoptotic process involved in outflow tract morphogenesis
Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.
apoptosis involved in endocardial cushion morphogenesis
apoptotic process involved in endocardial cushion morphogenesis
Any apoptotic process that contributes to the shaping of the heart.
apoptosis involved in heart morphogenesis
apoptotic process involved in heart morphogenesis
The progression of a cardiac septum over time, from its initial formation to the mature structure.
The progression of the ventricular septum over time from its formation to the mature structure.
The progression of the atrial septum over time, from its initial formation to the mature structure.
The process in which an endocardial cushion cell becomes a cell of a cardiac septum.
The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development.
The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division.
The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart.
physiological cardiac muscle hypertrophy
The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube.
The process in which the anatomical structures of the heart rudiment are generated and organized.
The developmental process pertaining to the initial formation of the heart rudiment.
Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.
regulation of extracellular matrix constituent secretion
Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.
positive regulation of extracellular matrix constituent secretion
Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.
negative regulation of extracellular matrix constituent secretion
The process in which an amino acid is transported across a membrane.
Note that this term is not intended for use in annotating lateral movement within membranes.
The directed, self-propelled movement of a cilium.
Note that we deem cilium and microtubule-based flagellum to be equivalent.
The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum.
The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme.
The process in which the anatomical structure of the pericardium is generated and organized.
The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell.
cardiac endothelial cell differentiation
Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.
regulation of microtubule-based flagellum movement
Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.
positive regulation of microtubule-based flagellum movement
positive regulation of flagellar movement
positive regulation of flagellum movement
Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.
negative regulation of microtubule-based flagellum movement
negative regulation of flagellum movement
The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline.
norepinephrine secreting neuron differentiation
The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
norepinephrine secreting neuron development
The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord.
The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron that is part of the brainstem.
noradrenergic neuron differentiation involved in brainstem development
The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell.
establishment of cell polarity involved in ameboidal cell migration
Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell.
establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration
The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation.
establishment of cell polarity involved in gastrulation cell migration
Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation.
establishment or maintenance of cytoskeleton polarity involved in gastrulation
The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation.
epithelial cell morphogenesis involved in gastrulation
The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state.
The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup.
The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup.
The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.
Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye.
cell motility involved in camera-type eye morphogenesis
The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage.
chondrocyte differentiation involved in endochondral bone morphogenesis
The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized.
chondrocyte morphogenesis involved in endochondral bone morphogenesis
The increase in size or mass of an endochondral bone that contributes to the shaping of the bone.
The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone.
chondrocyte development involved in endochondral bone morphogenesis
A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex).
Note that, in addition to forming the root of the cellular component ontology, this term is recommended for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this.
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'.
A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds.
A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures.
Any triple helical collagen trimer that forms fibrils.
A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils.
A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes.
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
Note that this term has no relationship to 'membrane ; GO:0016020' because the basement membrane is not a lipid bilayer.
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term.
A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm.
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
The double lipid bilayer that encloses the nucleus, separating its contents from the cytoplasm. It consists of an inner and outer nuclear membrane, with an intermembrane space (20-40 nm wide, also called the perinuclear space) between them. The envelope is supported by the nuclear lamina and contains nuclear pore complexes, which regulate molecular transport.
The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes.
A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.
The volume enclosed within the vacuolar membrane.
A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon.
Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell.
Note that this definition includes vesicles that are transiently associated with the Golgi.
A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.
In most eukaryotic cells, 'ciliary basal body' (GO:0036064) and 'centriole' (GO:0005814) represent a common entity that cycles through its function in cell division, then ciliogenesis, then cell division again. However, these structures are modified extensively as they transition into each other, and may contain different proteins, specific to each component.
An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules.
Any microtubule in the nucleus of a cell.
Any microtubule in the cytoplasm of a cell.
non-spindle-associated astral microtubule
A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects.
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. Also, 'cilium' may be used when axonemal structure and/or motility are unknown, or when axonemal structure is unusual. For all other cases, please refer to children of 'cilium'. Finally, note that any role of ciliary proteins in sensory events should be captured by annotating to relevant biological process terms.
The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
Note that cilia and eukaryotic flagella are deemed to be equivalent. In diplomonad species, such as Giardia, the axoneme may extend intracellularly up to 5um away from the plane of the plasma membrane.
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.
multicellular organismal polysaccharide metabolic process
The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages.
The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages.
The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any one of a group of linear polysaccharides composed of repeating disaccharide units.
The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.
The chemical reactions and pathways involving acetate, the anion of acetic acid.
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates.
regulation of carbohydrate metabolic process
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase-containing compound metabolic process
The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
establishment or maintenance of chromatin architecture
DNA replication-independent chromatin assembly
DNA replication-independent chromatin organization
DNA replication-independent nucleosome organisation
DNA replication-independent nuclesome assembly
transcription-coupled nucleosome assembly
A process in which RNA is transported to, or maintained in, a specific location.
establishment and maintenance of RNA localization
The import of RNA from the cytoplasm to the nucleus.
The directed movement of RNA from the nucleus to the cytoplasm.
The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.
The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
Any process that modulates the frequency, rate or extent of translational initiation.
Any process that modulates the frequency, rate, extent or accuracy of translational elongation.
Any process that modulates the frequency, rate or extent of translational termination.
The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.
The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups.
cellular amino acid and derivative metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids.
regulation of amino acid metabolic process
Regulation of ornithine decarboxylase (ODC)
The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.
cellular biogenic amine metabolic process
The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.
The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group.
The directed movement of a protein from the cytoplasm to the nucleus.
establishment of protein localization to nucleus
protein transport from cytoplasm to nucleus
The directed movement of a protein from the nucleus into the cytoplasm.
protein transport from nucleus to cytoplasm
copper-induced protein export from nucleus
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane.
The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.
The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.
The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein.
Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport.
The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.
Transport of inorganic cations/anions and amino acids/oligopeptides
The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.
Serotonin Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle
The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems.
The directed movement of acetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
The directed movement of acetate across a plasma membrane.
The transport of substances that occurs outside cells.
The directed extracellular movement of amino acids.
The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Amino acid transport across the plasma membrane
The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
copper-induced intracellular protein transport
A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for example of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles.
The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis.
Golgi to plasma membrane vesicle-mediated transport
The directed movement of substances from the Golgi to the vacuole.
Golgi to vacuole vesicle-mediated transport
The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo.
Fusion of the membrane of a transport vesicle with its target membrane.
The directed movement of molecules between the nucleus and the cytoplasm.
Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane, and is not traversed.
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis.
cellular component disassembly involved in apoptotic process
cellular component disassembly involved in apoptosis
cellular component disassembly involved in execution phase of apoptosis
A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
Any process that modulates the frequency, rate or extent of muscle contraction.
A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length.
Any process that modulates the frequency, rate or extent of smooth muscle contraction.
A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope.
Any process that modulates the frequency, rate or extent of striated muscle contraction.
regulation of striated muscle contraction
The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division.
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus.
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope.
nuclear envelope organization and biogenesis
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus.
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.
plasma membrane organization and biogenesis
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
cytoskeletal organization and biogenesis
cytoskeleton organization and biogenesis
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
regulation of actin filament localization
Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.
A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
The removal of tubulin heterodimers from one or both ends of a microtubule.
microtubule depolymerization during nuclear congression
The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation).
Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol.
down regulation of microtubule depolymerization
down-regulation of microtubule depolymerization
downregulation of microtubule depolymerization
negative regulation of microtubule disassembly
inhibition of microtubule depolymerization
negative regulation of microtubule catastrophe
negative regulation of microtubule depolymerization
Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme.
negative regulation of microtubule depolymerization in axoneme
negative regulation of axonemal microtubule depolymerization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole.
The directed movement of substances into, out of or within a vacuole.
The aggregation, arrangement and bonding together of a set of components to form a junction between cells.
The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.
Condensation of Prometaphase Chromosomes
The mitotic cell cycle process in which the controlled partial or complete breakdown of the nuclear membranes during occurs during mitosis.
Any process that modulates the frequency, rate or extent of mitosis.
The directed movement of the nucleus to a specific location within a cell.
establishment of cell nucleus localization
establishment of localization of nucleus
A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell.
Note that this term should not be confused with 'abortive mitotic cell cycle ; GO:0033277'. Although abortive mitosis is sometimes called endomitosis, GO:0033277 refers to a process in which a mitotic spindle forms and chromosome separation begins.
A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline.
Note that female germ lines can be found in female or hermaphroditic organisms, so this term can be used to annotate gene products from hermaphrodites such as those of C. elegans. See also the biological process term 'meiotic nuclear division; GO:0140013'.
Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
establishment and/or maintenance of cell polarity
establishment and/or maintenance of cell polarization
establishment or maintenance of cell polarity
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not.
EGFR interacts with phospholipase C-gamma
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
CREB1 phosphorylation through the activation of Adenylate Cyclase
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Activation of Na-permeable kainate receptors
Activation of Ca-permeable Kainate Receptor
The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin.
The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment.
ionic insulation of neurons by glial cells
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
Note that this term was 'developmental process'.
The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.
The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction.
Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster.
The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster.
The union of male and female gametes to form a zygote.
The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm.
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
modulation of mitotic cell cycle progression
regulation of mitotic cell cycle progression
regulation of progression through mitotic cell cycle
The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo.
A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.
The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron.
Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts.
down regulation of neuroblast proliferation
down-regulation of neuroblast proliferation
downregulation of neuroblast proliferation
negative regulation of neuroblast proliferation
A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand.
De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.
Note that 'axonogenesis' differs from 'axon development' in that the latter also covers other processes, such as axon regeneration (regrowth after loss or damage, not necessarily of the whole axon).
The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional).
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.
The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure.
The process whose specific outcome is the progression of the ectodermal digestive tract over time, from its formation to the mature structure. The ectodermal digestive tract includes those portions that are derived from ectoderm.
The process in which the anatomical structures of the foregut are generated and organized.
The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues.
The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.
The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism.
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction.
The establishment of the sex of an organism by physical differentiation.
The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.
Attachment of the blastocyst to the uterine lining.
The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms.
respiratory gaseous exchange by respiratory system
The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.
1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews. 2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis).
The acquisition and processing of information and/or the storage and retrieval of this information over time.
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.
Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.
The orderly movement of mesodermal cells from one site to another.
The directed movement of organelles or molecules along microtubules in neuron projections.
The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons.
The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons.
Any process in which a protein is transported to, or maintained in, a specific location.
establishment and maintenance of asymmetric protein localization
establishment and maintenance of protein localization
A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
Note that, in addition to forming the root of the biological process ontology, this term is recommended for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this.
A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation.
Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions.
The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
This term should not be used for direct annotation, it is currently kept in GO as a placeholder for describing cell death phenotypes in uPHENO. When information is provided on a programmed cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Unintentional cell death, i.e. cell death caused by injury, ageing, or cell phenotypes observed as a result of a pathological mutation in an essential gene should NOT be annotated using GO terms.
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms.
Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of cell proliferation
positive regulation of cell population proliferation
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
negative regulation of cell proliferation
negative regulation of cell population proliferation
The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues.
The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline.
The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.
The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.
The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity.
Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal.
The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.
The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.
The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure.
The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster.
The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y.
The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.
cellular amino acid biosynthetic process
A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
multicellular organismal biosynthetic process
The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine.
The controlled release of proteins from a cell.
protein secretion during cell fate commitment
protein secretion resulting in cell fate commitment
The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.
The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.
response to electromagnetic radiation stimulus
Note that 'radiation' refers to electromagnetic radiation of any wavelength.
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).
The series of events in which an external stimulus is received by a cell and converted into a molecular signal.
The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal.
The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal.
The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm.
The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal.
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus.
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent.
catechol-containing compound metabolic process
The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent.
catechol-containing compound biosynthetic process
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism.
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus.
Any process that modulates the frequency, rate or extent of asymmetric cell division.
The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
Activation of HOX genes during differentiation
The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
embryo development ending in birth or egg hatching
The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases).
The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases).
The process that results in the patterns of cell differentiation that will arise in an embryo.
Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.
Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.
negative regulation of biosynthetic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.
positive regulation of biosynthetic process
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
negative regulation of organismal metabolism
inhibition of organismal metabolic process
negative regulation of multicellular organismal metabolic process
negative regulation of metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
positive regulation of multicellular organismal metabolic process
positive regulation of organismal metabolism
stimulation of organismal metabolic process
up-regulation of organismal metabolic process
positive regulation of metabolic process
The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis.
The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
anterior/posterior pattern specification
Any process that modulates the frequency, rate or extent of signal transduction.
Any process that activates or increases the frequency, rate or extent of signal transduction.
positive regulation of signaling pathway
positive regulation of signalling pathway
positive regulation of signal transduction
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.
negative regulation of signaling pathway
negative regulation of signalling pathway
negative regulation of signal transduction
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term.
The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete.
The process in which a relatively unspecialized cell acquires the specialized features of a glial cell.
The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
Compaction of chromatin structure prior to meiosis in eukaryotic cells.
chromosome condensation involved in meiotic cell cycle
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus.
The division of the zygote into two daughter cells that will adopt developmentally distinct potentials.
The regionalization process that specifies animal organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues.
The process in which the anatomical structures of the soma are generated and organized.
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system.
Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.
Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.
negative regulation of cell fate commitment
Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.
positive regulation of cell fate commitment
The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.
Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.
regulation of mesenchymal cell proliferation
The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes.
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availability of mRNA or circRNA for translation and thereby regulates the rate of production of the encoded protein via translation.
PP2A-mediated dephosphorylation of key metabolic factors
Expression and translocation of olfactory receptors
Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals.
Any process resulting in the physical partitioning and separation of an epidermal cell, any of the cells making up the epidermis, into daughter cells.
Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis.
The movement of substances between cells.
Any process that modulates the frequency, rate or extent of membrane disassembly.
Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
regulation of macromolecule biosynthetic process
Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
positive regulation of macromolecule biosynthetic process
Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
negative regulation of macromolecule biosynthetic process
Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
regulation of glycoprotein biosynthetic process
Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
positive regulation of glycoprotein biosynthetic process
Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
negative regulation of glycoprotein biosynthetic process
Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
regulation of endothelial cell migration
Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
positive regulation of endothelial cell migration
Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
negative regulation of endothelial cell migration
Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
positive regulation of macromolecule metabolic process
Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
negative regulation of macromolecule metabolic process
Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.
posttranscriptional regulation of gene expression
post-transcriptional regulation of gene expression
Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
regulation of cardiac muscle hypertrophy
Any process that modulates the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors.
Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
positive regulation of cardiac muscle hypertrophy
Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
negative regulation of cardiac muscle hypertrophy
Any process that increases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors.
positive regulation of cardiac muscle adaptation
Any process that decreases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors.
negative regulation of cardiac muscle adaptation
The activation of endogenous cellular processes that result in the death of a cell as part of its development.
programmed cell death involved in development
This process is part of the natural developmental program of some cell types, but it does not always happen as part of the development or shaping of a gross anatomical structure.
programmed cell death involved in cell development
Any process that modulates the frequency or rate of multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system.
regulation of Schwann cell proliferation
Any process that increases the frequency or rate of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system.
positive regulation of Schwann cell proliferation
Any process that decreases the frequency or extent of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system.
negative regulation of Schwann cell proliferation
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation.
The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism.
Any process that modulates the frequency, rate or extent of epithelial cell migration.
Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration.
negative regulation of epithelial cell migration
Any process that activates or increases the frequency, rate or extent of epithelial cell migration.
positive regulation of epithelial cell migration
Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.
positive regulation of organelle organisation
positive regulation of organelle organization and biogenesis
positive regulation of organelle organization
Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.
negative regulation of organelle organisation
negative regulation of organelle organization and biogenesis
negative regulation of organelle organization
Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
positive regulation of cell communication
Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
negative regulation of cell communication
Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death.
negative regulation of muscle cell apoptosis
negative regulation of muscle cell apoptotic process
A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle.
A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations.
A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death.
regulation of muscle cell apoptotic process
Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death.
positive regulation of muscle cell apoptosis
positive regulation of muscle cell apoptotic process
Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death.
regulation of striated muscle cell apoptosis
regulation of striated muscle cell apoptotic process
Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death.
positive regulation of striated muscle cell apoptosis
positive regulation of striated muscle cell apoptotic process
Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death.
down regulation of striated muscle cell apoptosis
down-regulation of striated muscle cell apoptosis
downregulation of striated muscle cell apoptosis
inhibition of striated muscle cell apoptosis
negative regulation of striated muscle cell apoptosis
negative regulation of striated muscle cell apoptotic process
Any process that modulates the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.
regulation of cardiac muscle cell apoptosis
regulation of cardiac muscle cell apoptotic process
Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.
positive regulation of cardiac muscle cell apoptosis
positive regulation of cardiac muscle cell apoptotic process
Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.
down regulation of cardiac muscle cell apoptosis
down-regulation of cardiac muscle cell apoptosis
downregulation of cardiac muscle cell apoptosis
inhibition of cardiac muscle cell apoptosis
negative regulation of cardiac muscle cell apoptosis
negative regulation of cardiac muscle cell apoptotic process
The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate.
Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine.
negative regulation of norepinephrine secretion
Any process that increases the frequency, rate or extent of the regulated release of norepinephrine.
positive regulation of norepinephrine secretion
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.
regulation of collagen metabolic process
Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.
negative regulation of collagen metabolic process
Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.
positive regulation of collagen metabolism
positive regulation of collagen metabolic process
Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.
regulation of extracellular matrix breakdown
regulation of extracellular matrix degradation
regulation of extracellular matrix disassembly
Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.
down regulation of extracellular matrix disassembly
down-regulation of extracellular matrix disassembly
downregulation of extracellular matrix disassembly
negative regulation of extracellular matrix breakdown
negative regulation of extracellular matrix degradation
inhibition of extracellular matrix disassembly
negative regulation of extracellular matrix disassembly
Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
regulation of epithelial to mesenchymal transition
Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
positive regulation of epithelial to mesenchymal transition
Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
negative regulation of epithelial to mesenchymal transition
Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules.
Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.
Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.
positive regulation of fibroblast cell migration
positive regulation of fibroblast migration
Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.
negative regulation of fibroblast cell migration
negative regulation of fibroblast migration
Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.
positive regulation of cell morphogenesis
Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.
negative regulation of cell morphogenesis
Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action.
Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
positive regulation of myotube differentiation
Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
negative regulation of myotube differentiation
The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia.
Any process in which a lipid is transported to, or maintained in, a specific location.
Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
positive regulation of steroid biosynthetic process
Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
negative regulation of steroid biosynthetic process
The cellular component assembly that is part of the initial shaping of the component during its developmental progression.
cellular component assembly involved in morphogenesis
Any process that modulates the frequency, rate or extent of cytoplasmic microtubule depolymerization.
regulation of cytoplasmic microtubule depolymerization
The removal of tubulin heterodimers from one or both ends of a cytoplasmic microtubule.
cytoplasmic microtubule depolymerization
Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
negative regulation of cell cycle process
Any process that modulates the frequency, rate or extent of amino acid import into a cell.
regulation of amino acid import across plasma membrane
Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell.
The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity.
establishment of localization by movement along microtubule
Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
regulation of neuron projection development
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
positive regulation of neurite biosynthesis
positive regulation of neurite development
positive regulation of neurite formation
positive regulation of neuron projection development
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
negative regulation of neurite biosynthesis
negative regulation of neurite development
negative regulation of neurite formation
negative regulation of neuron projection development
A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children.
A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
The lipid bilayer surrounding any membrane-bounded vesicle in the cell.
The process whose specific outcome is the progression of the morula over time. The morula is a spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum.
The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others.
The multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system.
Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia.
Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia.
Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia.
The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts.
The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron.
The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube.
The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts.
The formation of a thickened region of the neurectoderm that is roughly triangular in cross section. The neural keel develops from the neural plate and develops into the neural rod. Neural keel formation occurs during primary neurulation in teleosts.
The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column.
The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds.
The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell.
The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function.
Any process that modulates the frequency, rate or extent of Schwann cell differentiation.
regulation of Schwann cell differentiation
Any process that stops, prevents, or reduces the frequency, rate or extent of Schwann cell differentiation.
down regulation of Schwann cell differentiation
down-regulation of Schwann cell differentiation
downregulation of Schwann cell differentiation
inhibition of Schwann cell differentiation
negative regulation of Schwann cell differentiation
Any process that activates or increases the frequency, rate or extent of Schwann cell differentiation.
up regulation of Schwann cell differentiation
up-regulation of Schwann cell differentiation
upregulation of Schwann cell differentiation
activation of Schwann cell differentiation
stimulation of Schwann cell differentiation
positive regulation of Schwann cell differentiation
Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change.
Any process that activates or increases the frequency, rate or extent of neuron maturation.
positive regulation of neuron maturation
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation.
negative regulation of neuron maturation
The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function.
The regulated release of acetylcholine by a cell. The acetylcholine acts as a neurotransmitter that acts in both the peripheral nervous system (PNS) and central nervous system (CNS).
acetylcholine secretion, neurotransmission
Any process that modulates the frequency, rate or extent of the regulated release of acetylcholine.
regulation of acetylcholine secretion, neurotransmission
Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine.
up regulation of acetylcholine secretion
up-regulation of acetylcholine secretion
positive regulation of acetylcholine secretion, neurotransmission
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of acetylcholine.
down regulation of acetylcholine secretion
down-regulation of acetylcholine secretion
downregulation of acetylcholine secretion
negative regulation of acetylcholine secretion, neurotransmission
Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine.
Any process that modulates the frequency, rate or extent of the regulated release of serotonin.
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin.
positive regulation of serotonin release
negative regulation of serotonin secretion
Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin.
positive regulation of serotonin secretion
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.
The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells.
Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.
regulation of skeletal muscle plasticity
regulation of skeletal muscle adaptation
The enlargement or overgrowth of all or part of an organ due to an increase in size (not length) of individual muscle fibers without cell division. In the case of skeletal muscle cells this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils.
Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy.
negative regulation of muscle hypertrophy
Any process that activates or increases the frequency, rate or extent of muscle hypertrophy.
positive regulation of muscle hypertrophy
Any process that modulates the frequency, rate or extent of muscle hypertrophy.
Any process that activates or increases the frequency, rate or extent of muscle adaptation.
positive regulation of muscle plasticity
positive regulation of muscle adaptation
Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation.
negative regulation of muscle plasticity
negative regulation of muscle adaptation
Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.
Any process that modulates the frequency, rate or extent of somitogenesis.
The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism.
Any process that modulates the frequency, rate or extent of skeletal muscle contraction.
regulation of skeletal muscle contraction
Any process that modulates the frequency, rate or extent of skeletal muscle contraction by variation of the pattern of stimulation by nervous system.
regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction
The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle.
The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population.
Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation.
regulation of skeletal muscle cell proliferation
Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation.
positive regulation of skeletal muscle cell proliferation
Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle cell proliferation.
negative regulation of skeletal muscle cell proliferation
The regulated release of neurotransmitter into the synaptic cleft involved in skeletal muscle contraction. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin.
neurotransmitter secretion involved in control of skeletal muscle contraction
neurotransmitter secretion involved in regulation of skeletal muscle contraction
Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes.
regulation of skeletal muscle contraction via membrane action potential
regulation of skeletal muscle contraction via regulation of action potential
The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells.
The process resulting in the physical partitioning and separation of a myoblast into daughter cells. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation.
response to stimulus involved in regulation of muscle plasticity
response to stimulus involved in regulation of muscle adaptation
The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors.
Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.
The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy.
The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy.
The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils.
The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
The orderly movement of a smooth muscle cell from one site to another, often during the development of a multicellular organism.
Any process that modulates the frequency, rate or extent of smooth muscle cell migration.
regulation of smooth muscle cell migration
Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration.
positive regulation of smooth muscle cell migration
Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration.
negative regulation of smooth muscle cell migration
The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage.
The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage.
The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.
The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.
The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom.
The directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
The directed movement of acetylcholine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions.
The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.
The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
nucleobase, nucleoside, nucleotide and nucleic acid transport
nucleobase-containing compound transport
A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.
cellular component organisation at cellular level
cellular component organisation in other organism
cellular component organization at cellular level
cellular component organization in other organism
The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
metabolic process resulting in cell growth
non-developmental growth of a unicellular organism
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle.
The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.
Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon.
changes in polarization state of photoreceptor cell membrane
regulation of membrane potential in photoreceptor cell
The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
Any process that modulates the frequency, rate or extent of striated muscle development.
regulation of striated muscle tissue development
The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female.
Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster.
oocyte microtubule cytoskeleton organisation
oocyte microtubule cytoskeleton organization
The process in which the anatomical structures of embryonic epithelia are generated and organized.
The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure.
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues.
The directed movement of substances or organelles within the cytosol.
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum.
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects.
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells.
The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types.
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
down regulation of protein biosynthetic process
down-regulation of protein biosynthetic process
downregulation of protein biosynthetic process
negative regulation of protein anabolism
negative regulation of protein biosynthesis
negative regulation of protein biosynthetic process
negative regulation of protein formation
negative regulation of protein synthesis
inhibition of protein biosynthetic process
protein biosynthetic process inhibitor activity
Any process that modulates the frequency, rate or extent of exocytosis.
The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring.
Note that phenol metabolism is not included as a child of 'xenobiotic metabolism' because although it is synthesized industrially, phenol is also found naturally in animal wastes and other organic materials. It is often formed by the activity of microorganisms, which can chemically modify a variety of xenobiotic and naturally occurring phenolic compounds.
phenol-containing compound metabolic process
The specific behavior of an organism that is associated with reproduction.
reproductive behavior in a multicellular organism
multicellular organism reproductive behavior
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
Activation of gene expression by SREBF (SREBP)
Regulation of lipid metabolism by PPARalpha
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids.
Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
regulation of nucleobase-containing compound metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
regulation of multicellular organismal metabolic process
regulation of organismal metabolic process
The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission.
An action potential that occurs in a neuron.
The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. A painful stimulus is any physical or chemical event that has the potential to cause tissue damage (actual or perceived) and activates the nociceptive system.
The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid.
The chemical reactions and pathways involving a protein. Includes protein modification.
protein metabolic process and modification
multicellular organismal protein metabolic process
Any process involved in the maintenance of an internal steady state at the level of the cell.
The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients.
The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
Glyoxylate metabolism and glycine degradation
The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid).
Note that gametes may come from two organisms or from a single organism in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. Note also that sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times.
The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells.
The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues.
The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate.
ventral spinal cord interneuron differentiation
The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate.
The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output.
The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.
spinal cord motor neuron differentiation
The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of somatic motor neurons. Somatic motor neurons innervate skeletal muscle targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.
The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube.
The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate.
The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain.
The orderly movement of a cell that will reside in the hindbrain.
The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex.
The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived.
The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon.
The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.
The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.
The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.
midbrain-hindbrain boundary biosynthesis
The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.
The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.
The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.
midbrain-hindbrain boundary morphogenesis
The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.
Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.
The process whose specific outcome is the progression of the vagus nerve over time, from its formation to the mature structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis.
The process whose specific outcome is the progression of the accessory nerve over time, from its formation to the mature structure. In mice, the spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve.
The process whose specific outcome is the progression of the hypoglossal nerve over time, from its formation to the mature structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue.
The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.
The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.
A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.
The process in which the anatomical structure of the medulla oblongata is generated and organized. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.
The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.
A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.
The process in which the anatomical structure of the pons is generated and organized. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.
The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.
A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.
The process in which the anatomical structure of the rhombomere is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.
The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.
The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.
The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.
A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.
A developmental process, independent of morphogenetic (shape) change, that is required for the accessory nerve to attain its fully functional state. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve.
The process in which the anatomical structure of the accessory nerve is generated and organized. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve.
The process that gives rise to the accessory nerve. This process pertains to the initial formation of a structure from unspecified parts. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve.
A developmental process, independent of morphogenetic (shape) change, that is required for the glossopharyngeal nerve to attain its fully functional state. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.
The process in which the anatomical structure of the glossopharyngeal nerve is generated and organized. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.
The process that gives rise to the glossopharyngeal nerve. This process pertains to the initial formation of a structure from unspecified parts. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.
The process in which the anatomical structure of the hypoglossal nerve is generated and organized. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue.
A developmental process, independent of morphogenetic (shape) change, that is required for the hypoglossal nerve to attain its fully functional state. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue.
The process that gives rise to the hypoglossal nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue.
A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.
The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.
The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.
A developmental process, independent of morphogenetic (shape) change, that is required for the vagus nerve to attain its fully functional state. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis.
The process in which the anatomical structure of the vagus nerve is generated and organized. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis.
The process that gives rise to the vagus nerve. This process pertains to the initial formation of a structure from unspecified parts. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis.
The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure.
A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state.
A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state.
The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.
The process in which the anatomical structure of the locus ceruleus is generated and organized. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.
The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.
A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.
The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.
The process in which the anatomical structure of the superior olivary nucleus is generated and organized. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.
The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.
A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.
A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.
The process whose specific outcome is the progression of the hypoglossal nucleus over time, from its formation to the mature structure.
The process whose specific outcome is the progression of a salivary nucleus over time, from its formation to the mature structure.
The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure.
The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
The process whose specific outcome is the progression of a preganglionic parasympathetic fiber over time, from its formation to the mature structure. A preganglionic parasympathetic fiber is a cholinergic axonal fiber projecting from the CNS to a parasympathetic ganglion.
preganglionic parasympathetic fiber development
The orderly movement of cells from one site to another in the cerebral cortex.
The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain.
cerebral cortex radially oriented cell migration
The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex.
cerebral cortex radial glia guided migration
cerebral cortex radial glia-dependent cell migration
cerebral cortex radial glia-guided migration
The movement of a cell along the process of a radial glial cell involved in cerebral cortex glial-mediated radial migration.
cell locomotion involved in cerebral cortex glial-mediated radial migration
cell locomotion involved in cerebral cortex radial glia guided migration
cell motility involved in cerebral cortex radial glia guided migration
Rearrangements of the microtubule cytoskeleton that contribute to the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial migration.
modulation of microtubule cytoskeleton involved in cerebral cortex glial-mediated radial migration
modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration
The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex.
The intracellular signaling pathway that results in the cessation of cell movement involved in lamination of the cerebral cortex.
down regulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration
down-regulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration
downregulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration
negative regulation of cell locomotion involved in cerebral cortex glial-mediated radial migration
inhibition of cell locomotion involved in cerebral cortex glial-mediated radial cell migration
negative regulation of cell locomotion involved in cerebral cortex radial glia guided migration
negative regulation of cell motility involved in cerebral cortex radial glia guided migration
The creation of greater cell numbers in the forebrain due to cell division of progenitor cells.
The migration of a pyramidal neuron precursor from the ventricular zone to the correct layer of the cerebral cortex.
pyramidal neuron migration to cerebral cortex
The process in which a neuroblast or one of its progeny commits to a pyramidal neuron fate, migrates from the ventricular zone to the appropriate layer in the cortex and develops into a mature neuron.
The progression of a pyramidal neuron from its initial formation to its mature state.
The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of basal progenitor cells, neuroblasts that lose their contacts with the ventricular surface. Differentiation includes the processes involved in commitment of a cell to a specific fate.
abventricular progenitor cell differentiation
intermediate progenitor cell differentiation
non-surface dividing progenitor cell differentiation
The process in which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons.
The process in which a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain.
The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell.
The orderly movement of a cell from one site to another at least one of which is located in the forebrain.
The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex.
The process in which the neural tube is divided into specific regions along the rostrocaudal axis.
anterior-posterior neural tube patterning
The process whose specific outcome is the creation of the forebrain-midbrain boundary.
The process whose specific outcome is the formation of the hindbrain-spinal cord boundary.
hindbrain-spinal cord boundary formation
The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.
The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system.
central nervous system neuron differentiation
The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.
central nervous system neuron development
The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon.
The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.
The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate.
neural plate anterior/posterior pattern formation
neural plate anterior/posterior regionalization
Generation of cells within the nervous system.
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier.
The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
myelination in peripheral nervous system
The orderly movement of a cell from one site to another at least one of which is located in the telencephalon.
The orderly movement of glial cells through the telencephalon.
The multiplication or reproduction of telencephalon oligodendrocyte cells, resulting in the expansion of a cell population.
telencephalon oligodendrocyte cell migration
The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere.
The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure.
The cellular process that ensures successive accurate and complete genome replication and chromosome segregation.
The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere.
A cellular process that results in the breakdown of a cellular component.
cellular component disassembly at cellular level
A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism.
reproductive cellular process in multicellular organism
cellular process involved in reproduction in multicellular organism
A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.
A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis.
regulation of anatomical structure morphogenesis
Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized.
negative regulation of cell shape and cell size
positive regulation of cell shape and cell size
The aggregation, arrangement and bonding together of a cellular component.
cellular component assembly at cellular level
The process in which the anatomical structures of a gland are generated and organized.
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex.
ribonucleoprotein complex biogenesis and assembly
A process that results in the breakdown of the extracellular matrix.
The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex.
Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another.
regulation of gene expression as a consequence of signal transmission
signal transduction involved in regulation of gene expression
Any process that modulates the frequency, rate or extent of a signaling process.
The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change.
Any process that activates, maintains or increases the frequency, rate or extent of a signaling process.
positive regulation of signalling process
positive regulation of signaling process
Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process.
negative regulation of signaling process
negative regulation of signalling process
The process in which a signal is secreted or discharged into the extracellular medium from a cellular source.
The specification and formation of anisotropic intracellular organization or cell growth patterns.
bud site selection/establishment of cell polarity
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins.
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
cell projection organization and biogenesis
cell surface structure organization and biogenesis
Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon.
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
actin cytoskeleton organization and biogenesis
Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins.
Movement of a vesicle along an actin filament, mediated by motor proteins.
A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.
The regulated release of a peptide hormone from a cell.
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.
Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.
constitutive secretory pathway transport vesicle
Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'secretory granule ; GO:0030141'.
A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'transport vesicle ; GO:0030133'.
The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
extracellular matrix organization and biogenesis
Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix.
The chemical reactions and pathways involving glycosaminoglycans, any of a group of linear polysaccharides composed of repeating disaccharide units.
The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid. Hyaluronan is a type of non-sulfated glycosaminoglycan composed of the repeating disaccharide unit beta(1,4)-D-glucuronic acid-beta(1,3)-N-acetyl-D-glucosamine.
The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid. Hyaluronan is a type of non-sulfated glycosaminoglycan composed of the repeating disaccharide unit beta(1,4)-D-glucuronic acid-beta(1,3)-N-acetyl-D-glucosamine.
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte.
Formation of myofibrils, the repeating units of striated muscle.
The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.
Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis.
The compaction of chromatin during apoptosis.
The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA.
nuclear fragmentation involved in apoptotic nuclear change
Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
negative regulation of bone biosynthesis
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space.
The outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria) are defined as parts of this structure, see 'external encapsulating structure part'.
The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract.
The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.
Any process that modulates the frequency, rate or extent of cell migration.
Any process that activates or increases the frequency, rate or extent of cell migration.
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
The controlled breakdown of any cell membrane in the context of a normal process such as autophagy.
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins.
microtubule cytoskeleton-dependent nuclear positioning
microtubule cytoskeleton-dependent nucleus positioning
microtubule-dependent nuclear positioning
microtubule-dependent nucleus positioning
transport of nucleus, microtubule-mediated
The contractile fiber of smooth muscle cells.
The lipid bilayer surrounding a transport vesicle.
constitutive secretory pathway transport vesicle membrane
The lipid bilayer surrounding a cytoplasmic vesicle.
The lipid bilayer surrounding a vesicle associated with the Golgi apparatus.
The lipid bilayer surrounding a secretory granule.
The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell.
cytoskeleton-dependent intracellular transport
Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber.
establishment and maintenance of oocyte localization in egg chamber
establishment and maintenance of oocyte position during oogenesis
oocyte localisation involved in germarium-derived egg chamber formation
oogenesis, establishment and maintenance of oocyte localization
oocyte localization during germarium-derived egg chamber formation
oocyte localization involved in germarium-derived egg chamber formation
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
Any process that modulates the frequency, rate or extent of epithelial cell differentiation.
regulation of epithelial cell differentiation
Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation.
down regulation of epithelial cell differentiation
down-regulation of epithelial cell differentiation
downregulation of epithelial cell differentiation
inhibition of epithelial cell differentiation
negative regulation of epithelial cell differentiation
Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation.
up regulation of epithelial cell differentiation
up-regulation of epithelial cell differentiation
upregulation of epithelial cell differentiation
activation of epithelial cell differentiation
stimulation of epithelial cell differentiation
positive regulation of epithelial cell differentiation
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).
The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium).
The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.
The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages.
isthmomesencephalic boundary development
midbrain-hindbrain orgainizer development
Any collagen trimer that passes through a lipid bilayer membrane.
Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures.
establishment or maintenance of microtubule cytoskeleton polarity
Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures.
establishment or maintenance of cytoskeleton polarity
A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules.
Note that we deem cilia and microtubule-based flagella to be equivalent.
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins.
nuclear migration, microfilament-mediated
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow.
microtubule organising center organisation
microtubule organizing center organization and biogenesis
microtubule organizing center organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments.
actomyosin structure organization and biogenesis
Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins.
Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted.
The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure.
A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.
Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule.
microtubule polymerization or depolymerization
Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule.
regulation of microtubule polymerization or depolymerization
Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization.
down regulation of microtubule polymerization or depolymerization
down-regulation of microtubule polymerization or depolymerization
downregulation of microtubule polymerization or depolymerization
inhibition of microtubule polymerization or depolymerization
negative regulation of microtubule polymerization or depolymerization
Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization.
up regulation of microtubule polymerization or depolymerization
up-regulation of microtubule polymerization or depolymerization
upregulation of microtubule polymerization or depolymerization
activation of microtubule polymerization or depolymerization
stimulation of microtubule polymerization or depolymerization
positive regulation of microtubule polymerization or depolymerization
Any process that modulates the frequency, rate or extent of microtubule polymerization.
regulation of microtubule polymerization
Any process that modulates the frequency, rate or extent of microtubule depolymerization.
regulation of microtubule depolymerization
Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization.
down regulation of microtubule polymerization
down-regulation of microtubule polymerization
downregulation of microtubule polymerization
inhibition of microtubule polymerization
negative regulation of microtubule polymerization
Any process that activates or increases the frequency, rate or extent of microtubule polymerization.
up regulation of microtubule polymerization
up-regulation of microtubule polymerization
upregulation of microtubule polymerization
activation of microtubule polymerization
stimulation of microtubule polymerization
positive regulation of microtubule polymerization
Any process that activates or increases the frequency, rate or extent of microtubule depolymerization.
positive regulation of microtubule disassembly
up regulation of microtubule depolymerization
up-regulation of microtubule depolymerization
upregulation of microtubule depolymerization
activation of microtubule depolymerization
positive regulation of microtubule catastrophe
stimulation of microtubule depolymerization
positive regulation of microtubule depolymerization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell.
cytoplasmic microtubule organization and biogenesis
A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder).
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
The area of a motile cell closest to the direction of movement.
The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection.
The portion of the plasma membrane surrounding the leading edge of a motile cell.
Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly.
down regulation of protein complex assembly
down-regulation of protein complex assembly
downregulation of protein complex assembly
negative regulation of protein complex assembly
negative regulation of protein-containing complex assembly
Any process that activates or increases the frequency, rate or extent of protein complex assembly.
up regulation of protein complex assembly
up-regulation of protein complex assembly
upregulation of protein complex assembly
positive regulation of protein complex assembly
positive regulation of protein-containing complex assembly
Any process that modulates the frequency, rate or extent of vesicle fusion.
Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion.
Any process that activates or increases the frequency, rate or extent of vesicle fusion.
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.
regulation of cell projection organisation
regulation of cell projection organization and biogenesis
regulation of cell projection organization
Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.
down regulation of cell projection organization
down-regulation of cell projection organization
downregulation of cell projection organization
negative regulation of cell projection organisation
inhibition of cell projection organization
negative regulation of cell projection organization and biogenesis
negative regulation of cell projection organization
Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.
positive regulation of cell projection organisation
up regulation of cell projection organization
up-regulation of cell projection organization
upregulation of cell projection organization
activation of cell projection organization
stimulation of cell projection organization
positive regulation of cell projection organization and biogenesis
positive regulation of cell projection organization
Any process that modulates the frequency, rate or extent of a defense response.
Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response.
Any process that activates or increases the frequency, rate or extent of a defense response.
A vesicle found in the cytoplasm of a cell.
A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location.
establishment and maintenance of protein complex localization
cellular protein-containing complex localization
establishment and maintenance of cellular protein complex localization
A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT.
Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system.
regulation of neurological system process
regulation of neurophysiological process
Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process.
negative regulation of neurological process
negative regulation of neurological system process
negative regulation of neurophysiological process
negative regulation of nervous system process
Any process that activates or increases the frequency, rate or extent of a neurophysiological process.
positive regulation of neurological process
positive regulation of neurological system process
positive regulation of neurophysiological process
positive regulation of nervous system process
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.
The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope.
The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.
The volume enclosed by the nuclear inner membrane.
Any small, fluid-filled, spherical organelle enclosed by membrane.
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ciliary basal body, a short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum).
microtubule basal body organization and biogenesis
Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress.
down regulation of translation initiation in response to stress
down-regulation of translation initiation in response to stress
downregulation of translation initiation in response to stress
inhibition of translation initiation in response to stress
negative regulation of translational initiation in response to stress
Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress.
up regulation of translation initiation in response to stress
up-regulation of translation initiation in response to stress
upregulation of translation initiation in response to stress
activation of translation initiation in response to stress
stimulation of translation initiation in response to stress
positive regulation of translational initiation in response to stress
A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.
The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.
A process in which a protein or protein complex is maintained in a specific location in the cell cortex.
maintenance of protein location in cell cortex
Any process that modulates the frequency, rate or extent of a response to an external stimulus.
regulation of response to external stimulus
Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus.
down regulation of response to external stimulus
down-regulation of response to external stimulus
downregulation of response to external stimulus
inhibition of response to external stimulus
negative regulation of response to external stimulus
Any process that activates, maintains or increases the rate of a response to an external stimulus.
up regulation of response to external stimulus
up-regulation of response to external stimulus
upregulation of response to external stimulus
activation of response to external stimulus
stimulation of response to external stimulus
positive regulation of response to external stimulus
The lipid bilayer surrounding a dense core granule.
Any process that modulates the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine.
regulation of synaptic transmission, cholinergic
Any process that stops, prevents, or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine.
down regulation of synaptic transmission, cholinergic
down-regulation of synaptic transmission, cholinergic
downregulation of synaptic transmission, cholinergic
inhibition of synaptic transmission, cholinergic
negative regulation of synaptic transmission, cholinergic
Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine.
up regulation of synaptic transmission, cholinergic
up-regulation of synaptic transmission, cholinergic
upregulation of synaptic transmission, cholinergic
activation of synaptic transmission, cholinergic
stimulation of synaptic transmission, cholinergic
positive regulation of synaptic transmission, cholinergic
Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport
regulation of nucleobase-containing compound transport
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
down regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport
down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport
downregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport
inhibition of nucleobase, nucleoside, nucleotide and nucleic acid transport
negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport
negative regulation of nucleobase-containing compound transport
Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
up regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport
up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport
upregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport
activation of nucleobase, nucleoside, nucleotide and nucleic acid transport
stimulation of nucleobase, nucleoside, nucleotide and nucleic acid transport
positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport
positive regulation of nucleobase-containing compound transport
Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell.
Any process in which a dense core granule is transported to, and/or maintained in, a specific location within the cell.
Any process that modulates the frequency, rate or extent of the process of creating protein polymers.
Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers.
down regulation of protein polymerization
down-regulation of protein polymerization
downregulation of protein polymerization
negative regulation of protein polymerization
Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers.
positive regulation of protein polymerization
The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system.
The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system.
central nervous system myelin sheath formation
myelin formation in central nervous system
The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by Schwann cells in the peripheral nervous system.
myelin formation in peripheral nervous system
peripheral nervous system myelin sheath formation
peripheral nervous system myelin formation
The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction.
ensheathment of axons in central nervous system
axon ensheathment in central nervous system
The process in which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction.
ensheathment of axons in peripheral nervous system
peripheral nervous system axon ensheathment
Any process that modulates the frequency, rate or extent of chondrocyte differentiation.
regulation of chondrocyte differentiation
Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation.
down regulation of chondrocyte differentiation
down-regulation of chondrocyte differentiation
downregulation of chondrocyte differentiation
inhibition of chondrocyte differentiation
negative regulation of chondrocyte differentiation
Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation.
up regulation of chondrocyte differentiation
up-regulation of chondrocyte differentiation
upregulation of chondrocyte differentiation
activation of chondrocyte differentiation
stimulation of chondrocyte differentiation
positive regulation of chondrocyte differentiation
The directed movement of lipids within cells.
Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells.
regulation of intracellular lipid transport
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells.
down regulation of intracellular lipid transport
down-regulation of intracellular lipid transport
downregulation of intracellular lipid transport
inhibition of intracellular lipid transport
negative regulation of intracellular lipid transport
Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells.
up regulation of intracellular lipid transport
up-regulation of intracellular lipid transport
upregulation of intracellular lipid transport
activation of intracellular lipid transport
stimulation of intracellular lipid transport
positive regulation of intracellular lipid transport
Any process that modulates the frequency, rate or extent of the directed movement of substances within cells.
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells.
down regulation of intracellular transport
down-regulation of intracellular transport
downregulation of intracellular transport
negative regulation of intracellular transport
Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells.
up regulation of intracellular transport
up-regulation of intracellular transport
positive regulation of intracellular transport
Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere.
maintenance of protein localization in cell
The portion of the plasma membrane surrounding a neuron projection.
The portion of the plasma membrane surrounding a dendrite.
The portion of the plasma membrane surrounding a dendritic spine.
The directed movement of a protein from one location to another within a lipid bilayer.
The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication.
double-stranded RNA biosynthetic process
Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study.
The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).
The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits.
All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection.
plasma membrane bounded cell projection cytoplasm
All of the contents of a dendrite, excluding the surrounding plasma membrane.
Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion.
Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
regulation of establishment or maintenance of cell polarity
Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
regulation of cellular protein localisation
regulation of cellular protein localization
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides.
regulation of polysaccharide metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides.
regulation of polysaccharide biosynthetic process
Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton.
Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
down regulation of organic acid transport
down-regulation of organic acid transport
downregulation of organic acid transport
negative regulation of organic acid transport
Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
positive regulation of organic acid transport
The controlled release of a substance by a cell.
The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form.
peripheral blood mononuclear cell proliferation
Any process that modulates the frequency, rate or extent of mononuclear cell proliferation.
regulation of peripheral blood mononuclear cell proliferation
regulation of mononuclear cell proliferation
Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation.
negative regulation of PBMC proliferation
negative regulation of peripheral blood mononuclear cell proliferation
negative regulation of mononuclear cell proliferation
Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation.
up regulation of mononuclear cell proliferation
up-regulation of mononuclear cell proliferation
upregulation of mononuclear cell proliferation
activation of mononuclear cell proliferation
positive regulation of PBMC proliferation
positive regulation of peripheral blood mononuclear cell proliferation
stimulation of mononuclear cell proliferation
positive regulation of mononuclear cell proliferation
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
regulation of actin cytoskeleton organisation
regulation of actin cytoskeleton organization and biogenesis
regulation of actin cytoskeleton organization
The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.
regulation of collagen biosynthetic process
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.
negative regulation of collagen anabolism
negative regulation of collagen biosynthesis
negative regulation of collagen formation
negative regulation of collagen synthesis
negative regulation of collagen biosynthetic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.
positive regulation of collagen anabolism
positive regulation of collagen biosynthesis
positive regulation of collagen formation
positive regulation of collagen synthesis
positive regulation of collagen biosynthetic process
Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton.
regulation of actin filament-based process
The directed movement of amino acids from inside of a cell, across the plasma membrane and into the extracellular region.
amino acid export across plasma membrane
The directed movement of amino acids out of the vacuole, across the vacuolar membrane.
amino acid transmembrane export from vacuole
The directed movement of amino acids into the vacuole across the vacuolar membrane.
amino acid transmembrane import into vacuole
The disaggregation of a protein-containing macromolecular complex into its constituent components.
cellular macromolecule complex disassembly
The disaggregation of a protein-RNA complex into its constituent components.
The process in which a cellular entity is generated and organized. A cellular entity has granularity above the level of a protein complex but below that of an anatomical system.
cellular anatomical entity morphogenesis
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole.
The expansion of a muscle cell population by cell division.
Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage.
Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process.
regulation of myeloid cell apoptotic process
Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process.
down regulation of myeloid cell apoptosis
down-regulation of myeloid cell apoptosis
downregulation of myeloid cell apoptosis
negative regulation of myeloid cell apoptosis
negative regulation of myeloid cell apoptotic process
Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process.
positive regulation of myeloid cell apoptosis
positive regulation of myeloid cell apoptotic process
Any process in which a macromolecule is transported to, or maintained in, a specific location.
Any process in which a polysaccharide is transported to, or maintained in, a specific location.
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.
regulation of organelle organization and biogenesis
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome.
regulation of chromosome organization and biogenesis
Any process that modulates the frequency, rate or extent of sister chromatid segregation.
regulation of sister chromatid segregation
Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation.
negative regulation of sister chromatid segregation
Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis.
regulation of mitotic sister chromatid segregation
Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis.
negative regulation of mitotic sister chromatid segregation
The deposition or aggregation of coloring matter in a cell.
Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells.
regulation of intracellular protein transport
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines.
regulation of cellular amine metabolic process
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines.
negative regulation of cellular amine metabolic process
negative regulation of amine metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines.
positive regulation of cellular amine metabolic process
positive regulation of amine metabolic process
The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain.
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion.
secretory granule organization and biogenesis
A process in which a protein is transported to, or maintained in, a location within an organelle.
A process in which a protein is transported to, or maintained in, a location within a secretory granule.
protein localisation in secretory granule
protein localization in secretory granule
protein localization to secretory granule
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine.
down regulation of catecholamine secretion
down-regulation of catecholamine secretion
downregulation of catecholamine secretion
negative regulation of catecholamine secretion
Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine.
up regulation of catecholamine secretion
up-regulation of catecholamine secretion
positive regulation of catecholamine secretion
A process in which a ribosome is transported to, and/or maintained in, a specific location.
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus.
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus.
A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus.
establishment of protein localisation to Golgi
establishment of protein localization in Golgi
establishment of protein localization to Golgi
establishment of protein localization to Golgi apparatus
Any process of regulating the production and elimination of erythrocytes within an organism.
The process in which a carbohydrate is transported across a membrane.
A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.
ATP hydrolysis coupled ion transmembrane transport
Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.
negative regulation of syncytium formation by plasma membrane fusion
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides.
regulation of cellular amide metabolic process
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides.
negative regulation of cellular amide metabolic process
negative regulation of amide metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides.
positive regulation of cellular amide metabolic process
positive regulation of amide metabolic process
A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction.
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix.
Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system.
glial cell programmed cell death by apoptosis
programmed cell death of glia by apoptosis
programmed cell death of glial cells by apoptosis
Any process that modulates the frequency, rate, or extent of glial cell apoptotic process.
regulation of glial cell apoptotic process
Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process.
negative regulation of glial cell apoptosis
negative regulation of glial cell apoptotic process
Any process that activates or increases the frequency, rate, or extent of glial cell apoptotic process.
positive regulation of glial cell apoptosis
positive regulation of glial cell apoptotic process
Any apoptotic process in a smooth muscle cell. Smooth muscle consists of non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels.
programmed cell death of smooth muscle cells by apoptosis
programmed cell death, smooth muscle cells
smooth muscle cell programmed cell death by apoptosis
Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process.
regulation of smooth muscle cell apoptosis
regulation of smooth muscle cell apoptotic process
Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptotic process.
down regulation of smooth muscle cell apoptosis
down-regulation of smooth muscle cell apoptosis
downregulation of smooth muscle cell apoptosis
inhibition of smooth muscle cell apoptosis
negative regulation of smooth muscle cell apoptosis
negative regulation of smooth muscle cell apoptotic process
Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process.
up regulation of smooth muscle cell apoptosis
up-regulation of smooth muscle cell apoptosis
upregulation of smooth muscle cell apoptosis
activation of smooth muscle cell apoptosis
positive regulation of smooth muscle cell apoptosis
stimulation of smooth muscle cell apoptosis
positive regulation of smooth muscle cell apoptotic process
The directed movement of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
The process in which a solute is transported from one side of the vacuolar membrane to the other.
The process in which an amino acid is transported from one side of the vacuolar membrane to the other.
vacuolar amino acid transmembrane transport
Any process in which a protein is transported to, or maintained at, a specific location on a chromosome.
A process in which a protein transports or maintains the localization of another protein to the nucleus.
The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids.
nucleobase, nucleoside, nucleotide and nucleic acid anabolism
nucleobase, nucleoside, nucleotide and nucleic acid biosynthesis
nucleobase, nucleoside, nucleotide and nucleic acid formation
nucleobase, nucleoside, nucleotide and nucleic acid synthesis
nucleobase-containing compound biosynthetic process
Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.
down regulation of transmembrane transport
down-regulation of transmembrane transport
downregulation of transmembrane transport
negative regulation of membrane transport
negative regulation of transmembrane transport
Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.
positive regulation of membrane transport
up regulation of transmembrane transport
up-regulation of transmembrane transport
positive regulation of transmembrane transport
Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.
regulation of ion transmembrane transport
regulation of transmembrane ion transport
regulation of monoatomic ion transmembrane transport
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.
negative regulation of ion transmembrane transport
down regulation of transmembrane ion transport
down-regulation of transmembrane ion transport
downregulation of transmembrane ion transport
negative regulation of ion membrane transport
negative regulation of transmembrane ion transport
inhibition of transmembrane ion transport
negative regulation of monoatomic ion transmembrane transport
Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.
positive regulation of ion transmembrane transport
positive regulation of ion membrane transport
positive regulation of transmembrane ion transport
up regulation of transmembrane ion transport
up-regulation of transmembrane ion transport
upregulation of transmembrane ion transport
activation of transmembrane ion transport
stimulation of transmembrane ion transport
positive regulation of monoatomic ion transmembrane transport
The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion.
Note that this term has no relationship to 'membrane disassembly ; GO:0030397' because the basement membrane is not a lipid bilayer.
The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field.
The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual.
The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
Note that cilia and eukaryotic flagella are deemed to be equivalent.
The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch.
The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal.
Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow.
lumen formation in an anatomical structure
The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisions and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex.
Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo.
programmed cell death of ectopic germ cells
programmed cell death, ectopic germ cells
The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.
The process in which the anatomical structures of the internal genitalia are generated and organized. The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals.
The process in which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals.
The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals.
The increase in size or mass of an entire multicellular organism, as opposed to cell growth.
The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function.
Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes.
Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system.
The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis.
Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8.
The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.
A process in which a protein is transported to, or maintained at, a microtubule.
Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
The process in which acetate is transported across a membrane. Acetate is the 2-carbon carboxylic acid ethanoic acid.
The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes.
cell migration involved in vasculogenesis
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
intracellular signal transduction pathway
signal transmission via intracellular cascade
The directed movement of a protein to a specific location within the extracellular region.
establishment of protein localisation in extracellular region
establishment of protein localization in extracellular region
establishment of protein localization to extracellular region
The orderly movement of a hematopoietic stem cell from one site to another. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system.
The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly.
intraciliary transport involved in cilium morphogenesis
intraflagellar transport involved in cilium morphogenesis
intraciliary transport involved in cilium assembly
The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to compound eye morphogenesis.
cell proliferation involved in compound eye morphogenesis
The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an angioblast cell. Angioblasts are one of the two products formed from hemangioblast cells (the other being pluripotent hemopoietic stem cells).
angioblastic mesenchymal cell differentiation
The chemical reactions and pathways involving an indole alkaloid, an alkaloid containing an indole skeleton.
The chemical reactions and pathways resulting in the formation of an indole alkaloid, an alkaloid containing an indole skeleton.
The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow.
A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm.
Depending on the species, this region may have a distinct geometrically shaped electron-dense structure within the axonemal lumen visible in electron microscopy images; most animals don't display this inner structure. The axoneme extends through the ciliary transition zone, but only consists of the outer doublets. The central pair, axonemal spokes, and dynein complexes are not found in this part of the ciliary shaft. Note that the connecting cilium of the photoreceptor cells is thought to be equivalent to the transition zone.
The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system.
The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell.
vascular smooth muscle cell differentiation
vascular associated smooth muscle cell differentiation
The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta.
aortic smooth muscle cell differentiation
The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body.
The progression of the ascending aorta over time, from its initial formation to the mature structure. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once.
The progression of the descending aorta over time, from its initial formation to the mature structure. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once.
The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once.
The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body.
The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once.
The process in which the anatomical structures of the descending aorta are generated and organized. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once.
The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once.
The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle.
The regulated release of any steroid that acts as a hormone into the circulatory system.
The regulated release of an androgen into the circulatory system. Androgens are steroid hormones that stimulate or control the development and maintenance of masculine characteristics in vertebrates.
The process in which a relatively unspecialized cell acquires specialized features of a tongue muscle cell.
The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo.
The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force.
The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts.
A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues.
The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population.
The orderly movement of a Schwann cell from one site to another. A Schwann cell is a glial cell that ensheathes axons of neuron in the peripheral nervous system and is necessary for their maintenance and function.
A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns.
The portion of the plasma membrane surrounding a muscle cell projection.
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen.
This term should be used when a decrease in oxygen levels is not considered a stress response. For a hypoxic stress response, consider instead 'response to hypoxia ; GO:0001666'.
Any biological process involved in the maintenance of the steady-state number of epidermal stem cells within a population of cells.
The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon.
The characteristic movement of trunk neural crest cells from the neural tube to other locations in the vertebrate embryo.
The joining of two lipid bilayers that surround the Golgi apparatus to form a single Golgi membrane.
membrane fusion involved in Golgi reassembly
The increase in size or mass of an entire organism, a part of an organism or a cell.
See also the biological process term 'cell growth ; GO:0016049'.
Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development.
Self-propelled movement of a cell or organism from one location to another.
Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.
Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism.
Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.
regulation of multicellular organism growth
Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size.
negative regulation of multicellular organism growth
The first few specialized divisions of an activated animal egg.
Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.
Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
positive regulation of multicellular organism growth
Any process that activates or increases the frequency, rate or extent of embryonic development.
positive regulation of embryonic development
Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes.
Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached.
regulation of development, heterochronic
The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia.
Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines.
regulation of catecholamine metabolic process
The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins.
intraflagellar transport involved in cilium organization
intraflagellar transport involved in microtubule-based flagellum organisation
The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression).
The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes.
The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
Any process that modulates the frequency, rate or extent of cell proliferation.
regulation of cell population proliferation
The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane.
nuclear membrane-endoplasmic reticulum continuum
nuclear envelope-endoplasmic reticulum continuum
nuclear envelope-endoplasmic reticulum network
nuclear outer membrane-endoplasmic reticulum membrane network
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.
The aggregation, arrangement and bonding together of the mature ribosome and of its subunits.
Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus.
regulation of protein import into cell nucleus
regulation of protein transport from cytoplasm to nucleus
regulation of protein import into nucleus
Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
positive regulation of protein import into cell nucleus
positive regulation of protein transport from cytoplasm to nucleus
positive regulation of protein-nucleus import
up regulation of protein import into nucleus
up-regulation of protein import into nucleus
upregulation of protein import into nucleus
activation of protein import into nucleus
stimulation of protein import into nucleus
positive regulation of protein import into nucleus
Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus.
down regulation of protein import into nucleus
down-regulation of protein import into nucleus
downregulation of protein import into nucleus
negative regulation of protein import into cell nucleus
negative regulation of protein transport from cytoplasm to nucleus
negative regulation of protein-nucleus import
inhibition of protein import into nucleus
negative regulation of protein import into nucleus
Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.
cellular biogenic amine biosynthetic process
The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.
The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.
The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.
The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.
The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.
The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton.
indole-containing compound metabolic process
The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton.
indole-containing compound biosynthetic process
Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light.
Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve.
Any process that modulates the frequency, rate or extent of eye photoreceptor development.
regulation of eye photoreceptor development
regulation of eye photoreceptor cell development
Any process that activates or increases the frequency, rate or extent of eye photoreceptor development.
positive regulation of eye photoreceptor development
up regulation of eye photoreceptor cell development
up-regulation of eye photoreceptor cell development
upregulation of eye photoreceptor cell development
activation of eye photoreceptor cell development
stimulation of eye photoreceptor cell development
positive regulation of eye photoreceptor cell development
Any process that stops, prevents, or reduces the frequency, rate or extent of eye photoreceptor development.
down regulation of eye photoreceptor cell development
down-regulation of eye photoreceptor cell development
downregulation of eye photoreceptor cell development
negative regulation of eye photoreceptor development
inhibition of eye photoreceptor cell development
negative regulation of eye photoreceptor cell development
A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state.
The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
Any biological process involved in the maintenance of an internal steady state.
negative regulation of homeostatic process
positive regulation of homeostatic process
Any complex of actin, myosin, and accessory proteins.
The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell.
The process in which a relatively unspecialized cell acquires specialized features of a muscle cell.
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur.
The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Any process that modulates the occurrence or rate of cell death by apoptotic process.
This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.
TP53 Regulates Transcription of Cell Death Genes
A prolongation or process extending from a cell, e.g. a flagellum or axon.
Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.
regulation of Golgi to plasma membrane protein transport
Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.
down regulation of Golgi to plasma membrane protein transport
down-regulation of Golgi to plasma membrane protein transport
downregulation of Golgi to plasma membrane protein transport
inhibition of Golgi to plasma membrane protein transport
negative regulation of Golgi to plasma membrane protein transport
Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.
up regulation of Golgi to plasma membrane protein transport
up-regulation of Golgi to plasma membrane protein transport
upregulation of Golgi to plasma membrane protein transport
activation of Golgi to plasma membrane protein transport
stimulation of Golgi to plasma membrane protein transport
positive regulation of Golgi to plasma membrane protein transport
The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane.
Golgi to plasma membrane protein transport
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.
The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections.
The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide.
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite.
extracellular structure organization and biogenesis
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is positively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.
positive regulation of apoptotic process
NRIF signals cell death from the nucleus
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is negatively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.
negative regulation of apoptotic process
Regulation of PAK-2p34 activity by PS-GAP/RHG10
Regulation of activated PAK-2p34 by proteasome mediated degradation
Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
regulation of non-apoptotic programmed cell death
Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
positive regulation of non-apoptotic programmed cell death
positive regulation of programmed cell death
Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
down regulation of programmed cell death
down-regulation of programmed cell death
negative regulation of non-apoptotic programmed cell death
negative regulation of programmed cell death
The nucleus of a germ cell, a reproductive cell in multicellular organisms.
The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released.
Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location.
establishment and maintenance of translational machinery localization
establishment and maintenance of translational protein localization
regulation of translation by machinery localisation
regulation of translation by machinery localization
The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
multicellular organismal macromolecule metabolic process
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things.
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi.
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
intracellular membrane-enclosed organelle
intracellular membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
intracellular non-membrane-bounded organelle
intracellular non-membrane-enclosed organelle
The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.
Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.
down regulation of protein complex disassembly
down-regulation of protein complex disassembly
downregulation of protein complex disassembly
inhibition of protein complex disassembly
negative regulation of protein complex disassembly
negative regulation of protein-containing complex disassembly
Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.
up regulation of protein complex disassembly
up-regulation of protein complex disassembly
upregulation of protein complex disassembly
activation of protein complex disassembly
stimulation of protein complex disassembly
positive regulation of protein complex disassembly
positive regulation of protein-containing complex disassembly
Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.
regulation of protein complex disassembly
regulation of protein-containing complex disassembly
A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state.
Any process that modulates the frequency, rate or extent of protein complex assembly.
regulation of protein-containing complex assembly
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates.
regulation of carbohydrate biosynthetic process
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell.
extracellular non-membrane-bounded organelle
extracellular non-membrane-enclosed organelle
Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
positive regulation of monoatomic ion transport
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
negative regulation of monoatomic ion transport
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active.
Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
The process in which a myeloid precursor cell acquires specialized features of an erythrocyte without a nucleus. An example of this process is found in Mus musculus.
enucleate red blood cell differentiation
A developmental process, independent of morphogenetic (shape) change, that is required for an enucleate erythrocyte to attain its fully functional state. An enucleate erythrocyte is an erythrocyte without a nucleus.
A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus.
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds.
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
response to polypeptide hormone stimulus
The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon.
regulation of secondary metabolic process
The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells.
A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.
Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals.
Any process that modulates the frequency, rate or extent of muscle adaptation.
Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons.
regulation of apoptosis of neuronal cells
regulation of neuron programmed cell death
regulation of neuronal cell programmed cell death
regulation of programmed cell death of neuronal cells
regulation of programmed cell death, neurons
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
negative regulation of programmed cell death, neurons
negative regulation of neuron apoptotic process
Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.
positive regulation of programmed cell death, neurons
positive regulation of neuron apoptotic process
The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis.
Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels.
regulation of blood vessel endothelial cell migration
Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.
up regulation of blood vessel endothelial cell migration
up-regulation of blood vessel endothelial cell migration
upregulation of blood vessel endothelial cell migration
activation of blood vessel endothelial cell migration
stimulation of blood vessel endothelial cell migration
positive regulation of blood vessel endothelial cell migration
Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels.
down regulation of blood vessel endothelial cell migration
down-regulation of blood vessel endothelial cell migration
downregulation of blood vessel endothelial cell migration
inhibition of blood vessel endothelial cell migration
negative regulation of blood vessel endothelial cell migration
The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment.
regulation of respiratory gaseous exchange
The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech.
The process in which the anatomical structures of the tongue are generated and organized. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in man other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech.
The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.
The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.
The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells.
The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.
The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state.
ossification involved in skeletal development
ossification involved in bone maturation
Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex.
cellular macromolecular complex organization
cellular macromolecular complex subunit organisation
cellular macromolecular complex subunit organization
macromolecular complex subunit organisation
macromolecular complex subunit organization
protein-containing complex subunit organization
Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.
Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system.
Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system.
regulation of respiratory system process
A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component.
cellular component biogenesis at cellular level
Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component.
regulation of cellular component biogenesis
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.
Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component.
positive regulation of cellular component biogenesis
Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.
positive regulation of vacuole organisation
positive regulation of vacuole biogenesis
positive regulation of vacuole organization
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane.
A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator).
translation initiation (ternary) complex
The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.
The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.
Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.
The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule.
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck.
Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules.
A process in which a protein is transported to, or maintained in, a location within the cytoskeleton.
Any process evolved to enable an interaction with an organism of a different species.
interspecies interaction between organisms
interspecies interaction with other organisms
biological process involved in interspecies interaction between organisms
The aggregation, arrangement and bonding together of a set of components to form a motile cilium.
The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon.
secondary metabolite biosynthetic process
A change in the morphology or behavior of a chondrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. A chondrocyte is a polymorphic cell that forms cartilage.
A biological process that directly contributes to the process of producing new individuals, involving another organism.
A multicellular organism process which involves another multicellular organism of the same or different species.
The directed movement of proteins into an intracellular organelle, across a membrane.
protein transmembrane import into intracellular organelle
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
microtubule-based flagellum organization
The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell.
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle.
The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion.
development of primary sexual characteristics
The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate.
Note that this term was 'cell fate determination' but the term name was changed to better match its existing definition and the child term 'cell fate determination; GO:0001709' was also created.
Signaling at long or short range between cells that results in the commitment of a cell to a certain fate.
cell fate commitment, cell-cell signaling
cell fate commitment, cell-cell signalling
cell-cell signaling during in cell fate commitment
cell-cell signaling resulting in cell fate commitment
cell-cell signalling during cell fate commitment
cell-cell signalling resulting in cell fate commitment
cell-cell signalling involved in cell fate specification
cell-cell signaling involved in cell fate commitment
The directed movement of a protein to a specific location.
Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away.
Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system.
establishment and/or maintenance of neuroblast cell polarity
establishment or maintenance of neuroblast polarity
The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system.
establishment of neuroblast cell polarity
The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells.
cell-cell junction assembly and maintenance
intercellular junction assembly and maintenance
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell.
external encapsulating structure organisation
external encapsulating structure organization and biogenesis
external encapsulating structure organization
A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor.
The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.
The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers.
The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.
Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.
Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation.
negative regulation of cell differentiation
Any process that activates or increases the frequency, rate or extent of cell differentiation.
positive regulation of cell differentiation
Any process that modulates the frequency, rate or extent of adipocyte differentiation.
regulation of adipocyte cell differentiation
Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation.
down regulation of fat cell differentiation
down-regulation of fat cell differentiation
downregulation of fat cell differentiation
negative regulation of adipocyte cell differentiation
negative regulation of adipocyte differentiation
negative regulation of fat cell differentiation
Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.
positive regulation of adipocyte cell differentiation
positive regulation of adipocyte differentiation
up regulation of fat cell differentiation
up-regulation of fat cell differentiation
upregulation of fat cell differentiation
positive regulation of fat cell differentiation
Any process that modulates the frequency, rate or extent of endothelial cell differentiation.
regulation of endothelial cell differentiation
Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation.
down regulation of endothelial cell differentiation
down-regulation of endothelial cell differentiation
downregulation of endothelial cell differentiation
inhibition of endothelial cell differentiation
negative regulation of endothelial cell differentiation
Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation.
up regulation of endothelial cell differentiation
up-regulation of endothelial cell differentiation
upregulation of endothelial cell differentiation
activation of endothelial cell differentiation
stimulation of endothelial cell differentiation
positive regulation of endothelial cell differentiation
Any process that modulates the frequency, rate or extent of epidermal cell differentiation.
regulation of hypodermal cell differentiation
regulation of epidermal cell differentiation
Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation.
down regulation of epidermal cell differentiation
down-regulation of epidermal cell differentiation
downregulation of epidermal cell differentiation
inhibition of epidermal cell differentiation
negative regulation of hypodermal cell differentiation
negative regulation of epidermal cell differentiation
Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation.
up regulation of epidermal cell differentiation
up-regulation of epidermal cell differentiation
upregulation of epidermal cell differentiation
activation of epidermal cell differentiation
stimulation of epidermal cell differentiation
positive regulation of hypodermal cell differentiation
positive regulation of epidermal cell differentiation
Any process that modulates the frequency, rate or extent of lymphocyte differentiation.
regulation of lymphocyte differentiation
Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation.
down regulation of lymphocyte differentiation
down-regulation of lymphocyte differentiation
downregulation of lymphocyte differentiation
inhibition of lymphocyte differentiation
negative regulation of lymphocyte development
negative regulation of lymphocyte differentiation
Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation.
up regulation of lymphocyte differentiation
up-regulation of lymphocyte differentiation
upregulation of lymphocyte differentiation
activation of lymphocyte differentiation
stimulation of lymphocyte differentiation
positive regulation of lymphocyte development
positive regulation of lymphocyte differentiation
Any process that modulates the frequency, rate or extent of myeloid cell differentiation.
regulation of myeloid cell differentiation
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation.
down regulation of myeloid cell differentiation
down-regulation of myeloid cell differentiation
downregulation of myeloid cell differentiation
inhibition of myeloid cell differentiation
negative regulation of myeloid cell differentiation
Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation.
up regulation of myeloid cell differentiation
up-regulation of myeloid cell differentiation
upregulation of myeloid cell differentiation
activation of myeloid cell differentiation
stimulation of myeloid cell differentiation
positive regulation of myeloid cell differentiation
Any process that modulates the frequency, rate or extent of erythrocyte differentiation.
regulation of red blood cell differentiation
regulation of erythrocyte differentiation
Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation.
down regulation of erythrocyte differentiation
down-regulation of erythrocyte differentiation
downregulation of erythrocyte differentiation
negative regulation of RBC differentiation
negative regulation of red blood cell differentiation
inhibition of erythrocyte differentiation
negative regulation of erythrocyte differentiation
Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.
positive regulation of RBC differentiation
positive regulation of red blood cell differentiation
up regulation of erythrocyte differentiation
up-regulation of erythrocyte differentiation
upregulation of erythrocyte differentiation
activation of erythrocyte differentiation
stimulation of erythrocyte differentiation
positive regulation of erythrocyte differentiation
Any process that modulates the frequency, rate or extent of megakaryocyte differentiation.
regulation of megakaryocyte differentiation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation.
down regulation of megakaryocyte differentiation
down-regulation of megakaryocyte differentiation
downregulation of megakaryocyte differentiation
inhibition of megakaryocyte differentiation
negative regulation of megakaryocyte differentiation
Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation.
up regulation of megakaryocyte differentiation
up-regulation of megakaryocyte differentiation
upregulation of megakaryocyte differentiation
activation of megakaryocyte differentiation
stimulation of megakaryocyte differentiation
positive regulation of megakaryocyte differentiation
Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
down regulation of myoblast differentiation
down-regulation of myoblast differentiation
downregulation of myoblast differentiation
negative regulation of myoblast differentiation
Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
up regulation of myoblast differentiation
up-regulation of myoblast differentiation
upregulation of myoblast differentiation
positive regulation of myoblast differentiation
Any process that modulates the frequency, rate or extent of neuron differentiation.
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
down regulation of neuron differentiation
down-regulation of neuron differentiation
downregulation of neuron differentiation
negative regulation of neuron differentiation
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
positive regulation of neuron differentiation
Any process that modulates the frequency, rate or extent of epidermis development.
Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development.
down regulation of epidermis development
down-regulation of epidermis development
negative regulation of epidermal development
negative regulation of hypodermis development
negative regulation of epidermis development
Any process that activates or increases the frequency, rate or extent of epidermis development.
positive regulation of epidermal development
positive regulation of hypodermis development
positive regulation of epidermis development
Any process that modulates the frequency, rate or extent of glia cell differentiation.
regulation of glial cell differentiation
Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation.
down regulation of glial cell differentiation
down-regulation of glial cell differentiation
downregulation of glial cell differentiation
negative regulation of glia cell differentiation
negative regulation of neuroglia differentiation
inhibition of glial cell differentiation
negative regulation of glial cell differentiation
Any process that activates or increases the frequency, rate or extent of glia cell differentiation.
positive regulation of glia cell differentiation
positive regulation of neuroglia differentiation
up regulation of glial cell differentiation
up-regulation of glial cell differentiation
upregulation of glial cell differentiation
activation of glial cell differentiation
stimulation of glial cell differentiation
positive regulation of glial cell differentiation
Any process that activates or increases the frequency, rate or extent of the formation of a cilium.
positive regulation of flagellum assembly
positive regulation of flagellum biogenesis
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
positive regulation of protein anabolism
positive regulation of protein biosynthesis
positive regulation of protein biosynthetic process
positive regulation of protein formation
positive regulation of protein synthesis
up regulation of protein biosynthetic process
up-regulation of protein biosynthetic process
upregulation of protein biosynthetic process
activation of protein biosynthetic process
stimulation of protein biosynthetic process
Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid.
down regulation of amino acid metabolic process
down-regulation of amino acid metabolic process
downregulation of amino acid metabolic process
negative regulation of amino acid metabolism
inhibition of amino acid metabolic process
negative regulation of amino acid metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid.
positive regulation of amino acid metabolism
positive regulation of cellular amino acid metabolic process
up regulation of amino acid metabolic process
up-regulation of amino acid metabolic process
upregulation of amino acid metabolic process
activation of amino acid metabolic process
stimulation of amino acid metabolic process
positive regulation of amino acid metabolic process
Any process that modulates the frequency, rate or extent of angiogenesis.
Any process that activates or increases angiogenesis.
Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division.
down regulation of asymmetric cell division
down-regulation of asymmetric cell division
downregulation of asymmetric cell division
negative regulation of asymmetric cell division
Any process that activates or increases the frequency, rate or extent of asymmetric cell division.
up regulation of asymmetric cell division
up-regulation of asymmetric cell division
upregulation of asymmetric cell division
positive regulation of asymmetric cell division
Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
positive regulation of bone biosynthesis
Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
down regulation of progression through cell cycle
down-regulation of progression through cell cycle
downregulation of progression through cell cycle
negative regulation of cell cycle progression
negative regulation of progression through cell cycle
inhibition of progression through cell cycle
p75NTR negatively regulates cell cycle via SC1
Any process that activates or increases the rate or extent of progression through the cell cycle.
positive regulation of cell cycle progression
positive regulation of progression through cell cycle
up regulation of progression through cell cycle
up-regulation of progression through cell cycle
upregulation of progression through cell cycle
activation of progression through cell cycle
stimulation of progression through cell cycle
Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction.
negative regulation of cardiac contraction
negative regulation of heart contraction
Any process that activates or increases the frequency, rate or extent of heart contraction.
positive regulation of cardiac contraction
positive regulation of heart contraction
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids.
down regulation of lipid metabolic process
down-regulation of lipid metabolic process
downregulation of lipid metabolic process
negative regulation of lipid metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids.
up regulation of lipid metabolic process
up-regulation of lipid metabolic process
positive regulation of lipid metabolic process
Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis.
negative regulation of meiotic nuclear division
Any process that activates or increases the frequency, rate or extent of meiosis.
positive regulation of meiotic nuclear division
Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother.
negative regulation of mitotic nuclear division
Any process that activates or increases the frequency, rate or extent of mitosis.
positive regulation of mitotic nuclear division
Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development.
down regulation of striated muscle development
down-regulation of striated muscle development
downregulation of striated muscle development
inhibition of striated muscle development
negative regulation of striated muscle tissue development
Any process that activates or increases the frequency, rate or extent of striated muscle development.
up regulation of striated muscle development
up-regulation of striated muscle development
upregulation of striated muscle development
activation of striated muscle development
stimulation of striated muscle development
positive regulation of striated muscle tissue development
Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation.
down regulation of translational elongation
down-regulation of translational elongation
downregulation of translational elongation
negative regulation of translational elongation
Any process that activates or increases the frequency, rate or extent of translational elongation.
up regulation of translational elongation
up-regulation of translational elongation
upregulation of translational elongation
positive regulation of translational elongation
Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination.
down regulation of translational termination
down-regulation of translational termination
downregulation of translational termination
negative regulation of translational termination
Any process that activates or increases the frequency, rate or extent of translational termination.
up regulation of translational termination
up-regulation of translational termination
upregulation of translational termination
stimulation of translational termination
positive regulation of translational termination
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate.
down regulation of carbohydrate metabolic process
down-regulation of carbohydrate metabolic process
downregulation of carbohydrate metabolic process
negative regulation of carbohydrate metabolism
inhibition of carbohydrate metabolic process
negative regulation of carbohydrate metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate.
positive regulation of carbohydrate metabolism
up regulation of carbohydrate metabolic process
up-regulation of carbohydrate metabolic process
upregulation of carbohydrate metabolic process
activation of carbohydrate metabolic process
stimulation of carbohydrate metabolic process
positive regulation of carbohydrate metabolic process
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine.
down regulation of catecholamine metabolic process
down-regulation of catecholamine metabolic process
downregulation of catecholamine metabolic process
negative regulation of catecholamine metabolism
inhibition of catecholamine metabolic process
negative regulation of catecholamine metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine.
positive regulation of catecholamine metabolism
up regulation of catecholamine metabolic process
up-regulation of catecholamine metabolic process
upregulation of catecholamine metabolic process
activation of catecholamine metabolic process
stimulation of catecholamine metabolic process
positive regulation of catecholamine metabolic process
Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis.
Any process that activates or increases the frequency, rate or extent of exocytosis.
Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism.
Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism.
Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.
down regulation of progression through mitotic cell cycle
down-regulation of progression through mitotic cell cycle
downregulation of progression through mitotic cell cycle
negative regulation of mitotic cell cycle progression
negative regulation of progression through mitotic cell cycle
inhibition of progression through mitotic cell cycle
negative regulation of mitotic cell cycle
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.
positive regulation of mitotic cell cycle progression
positive regulation of progression through mitotic cell cycle
up regulation of progression through mitotic cell cycle
up-regulation of progression through mitotic cell cycle
upregulation of progression through mitotic cell cycle
activation of progression through mitotic cell cycle
stimulation of progression through mitotic cell cycle
positive regulation of mitotic cell cycle
Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction.
negative regulation of muscle contraction
Any process that activates or increases the frequency, rate or extent of muscle contraction.
positive regulation of muscle contraction
Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
negative regulation of nucleobase-containing compound metabolic process
Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
up regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
upregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
activation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
stimulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
positive regulation of nucleobase-containing compound metabolic process
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids.
down regulation of steroid metabolic process
down-regulation of steroid metabolic process
downregulation of steroid metabolic process
negative regulation of steroid metabolism
negative regulation of steroid metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids.
positive regulation of steroid metabolism
up regulation of steroid metabolic process
up-regulation of steroid metabolic process
upregulation of steroid metabolic process
stimulation of steroid metabolic process
positive regulation of steroid metabolic process
Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation.
down regulation of translational initiation
down-regulation of translational initiation
downregulation of translational initiation
negative regulation of translational initiation
Any process that activates or increases the frequency, rate or extent of translational initiation.
up regulation of translational initiation
up-regulation of translational initiation
upregulation of translational initiation
positive regulation of translational initiation
Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction.
down regulation of smooth muscle contraction
down-regulation of smooth muscle contraction
downregulation of smooth muscle contraction
negative regulation of smooth muscle contraction
Any process that activates or increases the frequency, rate or extent of smooth muscle contraction.
up regulation of smooth muscle contraction
up-regulation of smooth muscle contraction
upregulation of smooth muscle contraction
stimulation of smooth muscle contraction
positive regulation of smooth muscle contraction
Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction.
down regulation of striated muscle contraction
down-regulation of striated muscle contraction
downregulation of striated muscle contraction
inhibition of striated muscle contraction
negative regulation of striated muscle contraction
Any process that activates or increases the frequency, rate or extent of striated muscle contraction.
up regulation of striated muscle contraction
up-regulation of striated muscle contraction
upregulation of striated muscle contraction
activation of striated muscle contraction
stimulation of striated muscle contraction
positive regulation of striated muscle contraction
Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development.
down regulation of embryonic development
down-regulation of embryonic development
negative regulation of embryonic development
Any process that modulates the frequency, rate or extent of embryonic development.
The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid.
The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring.
phenol-containing compound biosynthetic process
The chemical reactions and pathways resulting in the formation of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group.
The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.
The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane.
The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster.
Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.
regulation of photoreceptor differentiation
regulation of photoreceptor cell differentiation
Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.
down regulation of photoreceptor cell differentiation
down regulation of photoreceptor differentiation
down-regulation of photoreceptor cell differentiation
down-regulation of photoreceptor differentiation
downregulation of photoreceptor cell differentiation
downregulation of photoreceptor differentiation
negative regulation of photoreceptor differentiation
inhibition of photoreceptor cell differentiation
inhibition of photoreceptor differentiation
negative regulation of photoreceptor cell differentiation
Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.
positive regulation of photoreceptor differentiation
up regulation of photoreceptor cell differentiation
up regulation of photoreceptor differentiation
up-regulation of photoreceptor cell differentiation
up-regulation of photoreceptor differentiation
upregulation of photoreceptor cell differentiation
upregulation of photoreceptor differentiation
activation of photoreceptor cell differentiation
activation of photoreceptor differentiation
stimulation of photoreceptor cell differentiation
stimulation of photoreceptor differentiation
positive regulation of photoreceptor cell differentiation
The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion.
development of primary female sexual characteristics
Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light.
Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision.
Any process that modulates the frequency, rate or extent of growth of an organ of an organism.
Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism.
Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism.
A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor.
The expansion of a lymphocyte population by cell division.
The establishment of the sex of a female organism by physical differentiation.
Programmed cell death that occurs in the developing retina.
Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium.
compound eye retinal cell programmed cell death
Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina.
regulation of retinal programmed cell death
regulation of retinal cell programmed cell death
Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina.
regulation of compound eye retinal cell programmed cell death
Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the retina.
positive regulation of retinal programmed cell death
up regulation of retinal programmed cell death
up-regulation of retinal programmed cell death
upregulation of retinal programmed cell death
activation of retinal programmed cell death
stimulation of retinal programmed cell death
positive regulation of retinal cell programmed cell death
Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the retina.
down regulation of retinal programmed cell death
down-regulation of retinal programmed cell death
downregulation of retinal programmed cell death
negative regulation of retinal programmed cell death
inhibition of retinal programmed cell death
negative regulation of retinal cell programmed cell death
Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina.
activation of retinal cell programmed cell death
stimulation of retinal cell programmed cell death
up regulation of retinal cell programmed cell death
up-regulation of retinal cell programmed cell death
upregulation of retinal cell programmed cell death
positive regulation of compound eye retinal cell programmed cell death
Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina.
down regulation of retinal cell programmed cell death
down-regulation of retinal cell programmed cell death
downregulation of retinal cell programmed cell death
inhibition of retinal cell programmed cell death
negative regulation of retina cell programmed cell death
negative regulation of compound eye retinal cell programmed cell death
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbamate stimulus. Carbamates are a group of insecticides and parasiticides that act by inhibiting cholinesterase.
The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state.
The controlled release of acid by a cell or a tissue.
The addition of tubulin heterodimers to one or both ends of a microtubule.
Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm.
regulation of nucleocytoplasmic transport
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus.
down regulation of nucleocytoplasmic transport
down-regulation of nucleocytoplasmic transport
downregulation of nucleocytoplasmic transport
inhibition of nucleocytoplasmic transport
negative regulation of nucleocytoplasmic transport
Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm.
up regulation of nucleocytoplasmic transport
up-regulation of nucleocytoplasmic transport
upregulation of nucleocytoplasmic transport
activation of nucleocytoplasmic transport
stimulation of nucleocytoplasmic transport
positive regulation of nucleocytoplasmic transport
Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm.
regulation of protein export from cell nucleus
regulation of protein export out of nucleus
regulation of protein transport from nucleus to cytoplasm
regulation of protein export from nucleus
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm.
down regulation of protein export from nucleus
down-regulation of protein export from nucleus
downregulation of protein export from nucleus
negative regulation of protein export from cell nucleus
negative regulation of protein export out of nucleus
negative regulation of protein transport from nucleus to cytoplasm
negative regulation of protein-nucleus export
inhibition of protein export from nucleus
negative regulation of protein export from nucleus
Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm.
positive regulation of protein export from cell nucleus
positive regulation of protein export out of nucleus
positive regulation of protein transport from nucleus to cytoplasm
positive regulation of protein-nucleus export
up regulation of protein export from nucleus
up-regulation of protein export from nucleus
upregulation of protein export from nucleus
activation of protein export from nucleus
stimulation of protein export from nucleus
positive regulation of protein export from nucleus
Any process that modulates the frequency, rate or extent of movement of RNA from the cytoplasm to the nucleus.
regulation of RNA import into cell nucleus
regulation of RNA transport from cytoplasm to nucleus
Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of RNA from the cytoplasm into the nucleus.
down regulation of RNA import into nucleus
down-regulation of RNA import into nucleus
downregulation of RNA import into nucleus
negative regulation of RNA import into cell nucleus
negative regulation of RNA transport from cytoplasm to nucleus
negative regulation of RNA-nucleus import
negative regulation of RNA import into nucleus
Any process that activates or increases the frequency, rate or extent of movement of RNA from the cytoplasm into the nucleus.
positive regulation of RNA import into cell nucleus
positive regulation of RNA transport from cytoplasm to nucleus
positive regulation of RNA-nucleus import
up regulation of RNA import into nucleus
up-regulation of RNA import into nucleus
positive regulation of RNA import into nucleus
Any process that modulates the frequency, rate or extent of the directed movement of RNA from the nucleus to the cytoplasm.
regulation of RNA export from cell nucleus
regulation of RNA transport from nucleus to cytoplasm
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of RNA from the nucleus into the cytoplasm.
down regulation of RNA export from nucleus
down-regulation of RNA export from nucleus
downregulation of RNA export from nucleus
negative regulation of RNA export from cell nucleus
negative regulation of RNA export out of nucleus
negative regulation of RNA transport from nucleus to cytoplasm
negative regulation of RNA-nucleus export
negative regulation of RNA export from nucleus
Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm.
positive regulation of RNA export from cell nucleus
positive regulation of RNA export out of nucleus
positive regulation of RNA transport from nucleus to cytoplasm
positive regulation of RNA-nucleus export
up regulation of RNA export from nucleus
up-regulation of RNA export from nucleus
positive regulation of RNA export from nucleus
The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells.
Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell.
Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell.
positive regulation of hormone secretion
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell.
negative regulation of hormone secretion
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.
positive regulation of lipid biosynthesis
up regulation of lipid biosynthetic process
up-regulation of lipid biosynthetic process
upregulation of lipid biosynthetic process
activation of lipid biosynthetic process
stimulation of lipid biosynthetic process
positive regulation of lipid biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.
regulation of lipid biosynthetic process
The controlled release of a substance by a cell or a tissue.
The directed movement of substances within a cell.
Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell.
regulation of neurotransmitter secretion
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter.
down regulation of neurotransmitter secretion
down-regulation of neurotransmitter secretion
downregulation of neurotransmitter secretion
inhibition of neurotransmitter secretion
negative regulation of neurotransmitter secretion
The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).
The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination.
The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized.
The developmental process that results in the deposition of coloring matter in an organism, tissue or cell.
Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism.
regulation of pigmentation during development
regulation of developmental pigmentation
Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism.
down regulation of developmental pigmentation
down-regulation of developmental pigmentation
downregulation of developmental pigmentation
negative regulation of developmental pigmentation
Any process that increases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism.
up regulation of developmental pigmentation
up-regulation of developmental pigmentation
upregulation of developmental pigmentation
activation of developmental pigmentation
stimulation of developmental pigmentation
positive regulation of developmental pigmentation
The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line.
The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes.
female germ-line stem cell asymmetric division
The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population.
Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
up regulation of fibroblast proliferation
up-regulation of fibroblast proliferation
upregulation of fibroblast proliferation
positive regulation of fibroblast proliferation
Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
down regulation of fibroblast proliferation
down-regulation of fibroblast proliferation
downregulation of fibroblast proliferation
negative regulation of fibroblast proliferation
The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles.
The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation.
vesicle targeting, to, from or within dictyosome
vesicle targeting, to, from or within Golgi
Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus.
regulation of vesicle targeting, to, from or within Golgi
The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system.
Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching.
The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi.
The creation of a single organelle from two or more organelles.
The creation of two or more organelles by division of one organelle.
The joining of 2 or more lipid bilayer membranes that surround the nucleus during the creation of a single nucleus from multiple nuclei.
nuclear membrane fusion during karyogamy
nuclear membrane fusion involved in karyogamy
The partitioning of organelles between daughter cells at cell division.
The partitioning of Golgi apparatus between daughter cells at cell division.
Golgi Cisternae Pericentriolar Stack Reorganization
The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord.
The process in which the anatomical structures of the axial mesoderm are generated and organized.
The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts.
The process in which the anatomical structures of the mesoderm are generated and organized.
The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell.
The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube.
The process in which the anatomical structures of the paraxial mesoderm are generated and organized.
The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts.
The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure.
The process in which the anatomical structures of the lateral mesoderm are generated and organized.
The process that gives rise to the lateral mesoderm. This process pertains to the initial formation of the structure from unspecified parts.
The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads.
The process in which the anatomical structures of the intermediate mesoderm are generated and organized.
The process that gives rise to the intermediate mesoderm. This process pertains to the initial formation of the structure from unspecified parts.
The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place.
The cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state.
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands.
The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter.
The process whose specific outcome is the progression of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia.
parasympathetic nervous system development
The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development.
regulation of timing of cell differentiation
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.
Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
positive regulation of physiological process
positive regulation of biological process
Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
negative regulation of physiological process
negative regulation of biological process
Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.
Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.
Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
positive regulation of cellular physiological process
Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
negative regulation of cellular physiological process
The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation.
haematopoietic or lymphoid organ development
haemopoietic or lymphoid organ development
hemopoietic or lymphoid organ development
hematopoietic or lymphoid organ development
The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure.
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.
The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed.
Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed.
Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.
Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure.
regulation of post-embryonic development
Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure.
down regulation of post-embryonic development
down-regulation of post-embryonic development
downregulation of post-embryonic development
inhibition of post-embryonic development
negative regulation of post-embryonic development
Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure.
up regulation of post-embryonic development
up-regulation of post-embryonic development
upregulation of post-embryonic development
activation of post-embryonic development
stimulation of post-embryonic development
positive regulation of post-embryonic development
Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
positive regulation of response to stimulus
Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
negative regulation of response to stimulus
The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another.
developmental growth of a unicellular organism
The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.
The process in which the anatomical structures of the eye are generated and organized.
The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
The process in which the anatomical structures of the eye are generated and organized during embryonic development.
The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.
embryonic anatomical structure morphogenesis
The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte.
oocyte morphogenesis during differentiation
The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures.
The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs.
reproductive process in a multicellular organism
multicellular organismal reproductive process
The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast to attain its fully functional state. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size.
Any process that modulates the frequency, rate or extent of skeletal muscle growth.
regulation of skeletal muscle tissue growth
Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle growth.
down regulation of skeletal muscle growth
down-regulation of skeletal muscle growth
downregulation of skeletal muscle growth
negative regulation of skeletal muscle tissue growth
Any process that activates, maintains or increases the rate of skeletal muscle growth.
positive regulation of skeletal muscle tissue growth
Any process that modulates the frequency, rate or extent of muscle development.
Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development.
negative regulation of muscle organ development
Any process that activates, maintains or increases the rate of muscle development.
positive regulation of muscle organ development
Any process that modulates the frequency, rate or extent of developmental growth.
Any process that activates, maintains or increases the rate of developmental growth.
positive regulation of developmental growth
Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth.
negative regulation of developmental growth
Any process that modulates the frequency, rate or extent of skeletal muscle tissue development.
regulation of skeletal muscle tissue development
Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development.
down regulation of skeletal muscle development
down-regulation of skeletal muscle development
downregulation of skeletal muscle development
inhibition of skeletal muscle development
negative regulation of skeletal muscle tissue development
Any process that activates, maintains or increases the rate of skeletal muscle tissue development.
up regulation of skeletal muscle development
up-regulation of skeletal muscle development
upregulation of skeletal muscle development
activation of skeletal muscle development
stimulation of skeletal muscle development
positive regulation of skeletal muscle tissue development
The process in which the anatomical structures of muscle are generated and organized.
The process pertaining to the initial formation of an animal organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ.
initiation of an animal organ primordium
The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
formation of an anatomical structure involved in morphogenesis
Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense.
anatomical structure formation involved in morphogenesis
The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population.
Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation.
regulation of smooth muscle cell proliferation
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
positive regulation of SMC proliferation
up regulation of smooth muscle cell proliferation
up-regulation of smooth muscle cell proliferation
upregulation of smooth muscle cell proliferation
activation of smooth muscle cell proliferation
stimulation of smooth muscle cell proliferation
positive regulation of smooth muscle cell proliferation
Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation.
down regulation of smooth muscle cell proliferation
down-regulation of smooth muscle cell proliferation
downregulation of smooth muscle cell proliferation
negative regulation of SMC proliferation
inhibition of smooth muscle cell proliferation
negative regulation of smooth muscle cell proliferation
The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron.
neuron morphogenesis involved in differentiation
cell morphogenesis involved in neuron differentiation
The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons.
The process in which the anatomical structures of the skeleton are generated and organized.
The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system.
Any process that modulates the frequency, rate or extent of oligodendrocyte differentiation.
regulation of oligodendrocyte differentiation
Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation.
up regulation of oligodendrocyte differentiation
up-regulation of oligodendrocyte differentiation
upregulation of oligodendrocyte differentiation
activation of oligodendrocyte differentiation
stimulation of oligodendrocyte differentiation
positive regulation of oligodendrocyte differentiation
Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation.
down regulation of oligodendrocyte differentiation
down-regulation of oligodendrocyte differentiation
downregulation of oligodendrocyte differentiation
inhibition of oligodendrocyte differentiation
negative regulation of oligodendrocyte differentiation
The process in which the anatomical structures of a tissue are generated and organized.
The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion.
The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch.
The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.
The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
regulation of skeletal muscle fibre development
regulation of skeletal myofiber development
regulation of skeletal myofibre development
regulation of skeletal muscle fiber development
Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
positive regulation of skeletal muscle fibre development
positive regulation of skeletal myofiber development
positive regulation of skeletal myofibre development
up regulation of skeletal muscle fiber development
up-regulation of skeletal muscle fiber development
upregulation of skeletal muscle fiber development
activation of skeletal muscle fiber development
stimulation of skeletal muscle fiber development
positive regulation of skeletal muscle fiber development
Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
down regulation of skeletal muscle fiber development
down-regulation of skeletal muscle fiber development
downregulation of skeletal muscle fiber development
negative regulation of skeletal muscle fibre development
negative regulation of skeletal myofiber development
negative regulation of skeletal myofibre development
inhibition of skeletal muscle fiber development
negative regulation of skeletal muscle fiber development
The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure.
The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye.
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule.
pigment granule organization and biogenesis
The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder.
branching morphogenesis of an epithelial tube
The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron).
The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.
A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes.
A developmental process, independent of morphogenetic (shape) change, that is required for an animal organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions.
The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure.
The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
The process in which the anatomical structures of a dendrite are generated and organized.
Any process that modulates the frequency, rate or extent of dendrite morphogenesis.
The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure.
The process aimed at the progression of an enucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs.
The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart.
The process in which the anatomical structures of the diencephalon are generated and organized. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex.
The process in which the anatomical structures of the forebrain are generated and organized. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma.
The process in which the anatomical structures of a cell projection are generated and organized.
The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
The process resulting in the physical partitioning and separation of a glioblast into daughter cells.
The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate.
A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.
Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
Any process involved in the maintenance of an internal steady state at the level of the multicellular organism.
multicellular organismal-level homeostasis
Any biological process involved in the maintenance of the steady-state number of cells within a population of cells.
The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure.
The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system.
peripheral nervous system neuron differentiation
The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.
peripheral nervous system neuron development
Any process in which a chromosome is transported to, or maintained in, a specific location.
establishment and maintenance of chromosome localization
establishment and maintenance of chromosome position
The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.
Any process that modulates the frequency, rate or extent of the regulated release of catecholamines.
The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Any process that modulates the frequency, rate or extent of lymphocyte proliferation.
Any process that activates or increases the rate or extent of lymphocyte proliferation.
up regulation of lymphocyte proliferation
up-regulation of lymphocyte proliferation
upregulation of lymphocyte proliferation
positive regulation of lymphocyte proliferation
Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation.
down regulation of lymphocyte proliferation
down-regulation of lymphocyte proliferation
downregulation of lymphocyte proliferation
negative regulation of lymphocyte proliferation
The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances.
Any process that modulates the frequency, rate or extent of epithelial cell proliferation.
regulation of epithelial cell proliferation
Any process that activates or increases the rate or extent of epithelial cell proliferation.
up regulation of epithelial cell proliferation
up-regulation of epithelial cell proliferation
upregulation of epithelial cell proliferation
activation of epithelial cell proliferation
stimulation of epithelial cell proliferation
positive regulation of epithelial cell proliferation
Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
down regulation of epithelial cell proliferation
down-regulation of epithelial cell proliferation
downregulation of epithelial cell proliferation
inhibition of epithelial cell proliferation
negative regulation of epithelial cell proliferation
Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell.
Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.
negative regulation of protein secretion
Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.
positive regulation of protein secretion
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
down regulation of inflammatory response
down-regulation of inflammatory response
negative regulation of inflammatory response
Biosynthesis of specialized proresolving mediators (SPMs)
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
positive regulation of inflammatory response
Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.
Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.
Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis.
Axonal growth inhibition (RHOA activation)
Any process that activates or increases the frequency, rate or extent of axonogenesis.
Any process that modulates the frequency, rate or extent of dendrite development.
Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis.
down regulation of dendrite morphogenesis
down-regulation of dendrite morphogenesis
downregulation of dendrite morphogenesis
negative regulation of dendrite morphogenesis
Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis.
positive regulation of dendrite morphogenesis
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
regulation of cellular physiological process
Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.
Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
regulation of synapse structure or activity
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
regulation of chemical synaptic transmission
modulation of chemical synaptic transmission
Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
down regulation of synaptic transmission
down-regulation of synaptic transmission
negative regulation of synaptic transmission
Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
positive regulation of synaptic transmission
Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
regulation of synapse organization and biogenesis
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
regulation of steroid biosynthetic process
Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.
Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation.
Any process that activates or increases the frequency, rate or extent of activation.
An organ system process carried out by any of the organs or tissues of the neurological system.
Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism.
The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system.
The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system.
The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
The movement of a leukocyte within or between different tissues and organs of the body.
Cell surface interactions at the vascular wall
Any process pertaining to the functions of the nervous and muscular systems of an organism.
The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal.
sensory perception, sensory transduction of stimulus
detection of stimulus involved in sensory perception
The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception.
sensory detection of chemical stimulus during sensory perception
sensory perception, sensory detection of chemical stimulus
sensory perception, sensory transduction of chemical stimulus
sensory transduction of chemical stimulus
sensory transduction of chemical stimulus during sensory perception
detection of chemical stimulus involved in sensory perception
The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal.
sensory detection of light during visual perception
sensory detection of light stimulus during visual perception
sensory transduction of light during visual perception
sensory transduction of light stimulus during visual perception
visual perception, detection of light stimulus
visual perception, sensory transduction during perception of light
visual perception, sensory transduction of light stimulus
detection of light stimulus involved in visual perception
The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process.
The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal.
perception of taste, detection of chemical stimulus
perception of taste, sensory detection of chemical stimulus
perception of taste, sensory transduction of chemical stimulus
sensory detection of chemical stimulus during perception of taste
sensory transduction of chemical stimulus during perception of taste
detection of chemical stimulus involved in sensory perception of taste
The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte.
Note that the chromatophore mentioned here is distinct from the pigment bearing structure found in certain photosynthetic bacteria and cyanobacteria. It is also different from the plant chromoplast, which is also sometimes called a chromatophore.
Any process that modulates the frequency, rate or extent of pigmented cell differentiation.
regulation of pigment cell differentiation
Any process that stops, prevents, or reduces the frequency, rate or extent of pigment cell differentiation.
down regulation of pigment cell differentiation
down-regulation of pigment cell differentiation
downregulation of pigment cell differentiation
inhibition of pigment cell differentiation
negative regulation of pigment cell differentiation
Any process that activates or increases the frequency, rate or extent of pigment cell differentiation.
up regulation of pigment cell differentiation
up-regulation of pigment cell differentiation
upregulation of pigment cell differentiation
activation of pigment cell differentiation
stimulation of pigment cell differentiation
positive regulation of pigment cell differentiation
The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
sensory perception of mechanical stimulus
The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light.
sensory detection of light stimulus during sensory perception
sensory perception, sensory detection of light stimulus
sensory perception, sensory transduction of light stimulus
sensory transduction of light stimulus during sensory perception
detection of light stimulus involved in sensory perception
The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal.
perception of pain, detection of chemical stimulus
perception of pain, sensory detection of chemical stimulus
perception of pain, sensory transduction of chemical stimulus
sensory detection of chemical stimulus during perception of pain
sensory transduction of chemical stimulus during perception of pain
detection of chemical stimulus involved in sensory perception of pain
The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach).
Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.
Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.
Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.
Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.
down regulation of lipid biosynthetic process
down-regulation of lipid biosynthetic process
downregulation of lipid biosynthetic process
negative regulation of lipid biosynthesis
inhibition of lipid biosynthetic process
negative regulation of lipid biosynthetic process
The cell cycle process in which the controlled breakdown of the nuclear membranes during meiotic cell division occurs.
The controlled breakdown of the nuclear membranes, for example during cellular division.
Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
down regulation of developmental process
down-regulation of developmental process
negative regulation of developmental process
Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
positive regulation of developmental process
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
regulation of cellular component organisation
regulation of cellular component organization and biogenesis
regulation of cellular component organization
Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
negative regulation of cell organisation
negative regulation of cellular component organization and biogenesis
negative regulation of cellular component organization
Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
positive regulation of cell organisation
positive regulation of cellular component organization and biogenesis
positive regulation of cellular component organization
The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary.
The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle.
Any process that modulates the frequency, rate or extent of muscle cell differentiation.
regulation of muscle cell differentiation
Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation.
down regulation of muscle cell differentiation
down-regulation of muscle cell differentiation
downregulation of muscle cell differentiation
inhibition of muscle cell differentiation
negative regulation of muscle cell differentiation
Any process that activates or increases the frequency, rate or extent of muscle cell differentiation.
up regulation of muscle cell differentiation
up-regulation of muscle cell differentiation
upregulation of muscle cell differentiation
activation of muscle cell differentiation
stimulation of muscle cell differentiation
positive regulation of muscle cell differentiation
Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation.
regulation of smooth muscle cell differentiation
Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell differentiation.
down regulation of smooth muscle cell differentiation
down-regulation of smooth muscle cell differentiation
downregulation of smooth muscle cell differentiation
inhibition of smooth muscle cell differentiation
negative regulation of smooth muscle cell differentiation
Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation.
up regulation of smooth muscle cell differentiation
up-regulation of smooth muscle cell differentiation
upregulation of smooth muscle cell differentiation
activation of smooth muscle cell differentiation
stimulation of smooth muscle cell differentiation
positive regulation of smooth muscle cell differentiation
Any process that modulates the frequency, rate or extent of striated muscle cell differentiation.
regulation of striated muscle cell differentiation
Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation.
down regulation of striated muscle cell differentiation
down-regulation of striated muscle cell differentiation
downregulation of striated muscle cell differentiation
inhibition of striated muscle cell differentiation
negative regulation of striated muscle cell differentiation
Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation.
up regulation of striated muscle cell differentiation
up-regulation of striated muscle cell differentiation
upregulation of striated muscle cell differentiation
activation of striated muscle cell differentiation
stimulation of striated muscle cell differentiation
positive regulation of striated muscle cell differentiation
The directed movement of substances out of the nucleus.
The directed movement of substances into, out of, or within the nucleus.
The directed movement of substances into the nucleus.
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur.
down regulation of sulfur metabolic process
down-regulation of sulfur metabolic process
downregulation of sulfur metabolic process
negative regulation of sulfur metabolism
negative regulation of sulphur metabolic process
negative regulation of sulphur metabolism
negative regulation of sulfur metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur.
positive regulation of sulfur metabolism
positive regulation of sulphur metabolic process
positive regulation of sulphur metabolism
up regulation of sulfur metabolic process
up-regulation of sulfur metabolic process
upregulation of sulfur metabolic process
positive regulation of sulfur metabolic process
Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation.
establishment and maintenance of localization
establishment and maintenance of position
establishment and maintenance of cellular component location
establishment and maintenance of substance location
establishment and maintenance of substrate location
The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
positive regulation of protein transport
Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
negative regulation of protein transport
Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.
Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere.
The directed movement of RNA to a specific location.
Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.
regulation of multicellular organismal process
Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.
up regulation of multicellular organismal process
up-regulation of multicellular organismal process
upregulation of multicellular organismal process
activation of multicellular organismal process
stimulation of multicellular organismal process
positive regulation of multicellular organismal process
Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.
down regulation of multicellular organismal process
down-regulation of multicellular organismal process
downregulation of multicellular organismal process
inhibition of multicellular organismal process
negative regulation of multicellular organismal process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.
regulation of cellular protein metabolic process
regulation of cellular protein metabolism
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.
positive regulation of cellular protein metabolic process
positive regulation of cellular protein metabolism
positive regulation of protein metabolism
up regulation of cellular protein metabolic process
up regulation of protein metabolic process
up-regulation of cellular protein metabolic process
up-regulation of protein metabolic process
upregulation of cellular protein metabolic process
upregulation of protein metabolic process
activation of cellular protein metabolic process
stimulation of cellular protein metabolic process
stimulation of protein metabolic process
positive regulation of protein metabolic process
Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein.
down regulation of cellular protein metabolic process
down regulation of protein metabolic process
down-regulation of cellular protein metabolic process
down-regulation of protein metabolic process
downregulation of cellular protein metabolic process
downregulation of protein metabolic process
negative regulation of cellular protein metabolic process
negative regulation of cellular protein metabolism
negative regulation of protein metabolism
inhibition of cellular protein metabolic process
negative regulation of protein metabolic process
Any process that modulates the frequency, rate or extent of lymphocyte activation.
Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation.
down regulation of lymphocyte activation
down-regulation of lymphocyte activation
negative regulation of lymphocyte activation
Any process that activates or increases the frequency, rate or extent of lymphocyte activation.
positive regulation of lymphocyte activation
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA.
down regulation of RNA metabolic process
down-regulation of RNA metabolic process
negative regulation of RNA metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA.
positive regulation of RNA metabolic process
The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein.
The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein.
A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.
The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division.
Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells.
The directed movement of a chromosome to a specific location.
establishment of chromosome localisation
establishment of chromosome localization
Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
Note that this term should not be confused with 'GO:0140013 ; meiotic nuclear division'. 'GO:0051321 ; meiotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140013 meiotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle.
Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
neuron programmed cell death by apoptosis
neuronal cell programmed cell death by apoptosis
programmed cell death of neuronal cells by apoptosis
programmed cell death of neurons by apoptosis
The 'de novo' formation of a microtubule, mediated by the microtubule organizing center.
microtubule nucleation by microtubule organising centre
microtubule organizing center-mediated microtubule nucleation
microtubule nucleation by microtubule organizing center
Any process that modulates the rate or extent of progression through the meiotic cell cycle.
modulation of meiotic cell cycle progression
regulation of meiotic cell cycle progression
regulation of progression through meiotic cell cycle
Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle.
positive regulation of meiotic cell cycle progression
positive regulation of progression through meiotic cell cycle
up regulation of progression through meiotic cell cycle
up-regulation of progression through meiotic cell cycle
upregulation of progression through meiotic cell cycle
activation of progression through meiotic cell cycle
stimulation of progression through meiotic cell cycle
positive regulation of meiotic cell cycle
Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle.
down regulation of progression through meiotic cell cycle
down-regulation of progression through meiotic cell cycle
downregulation of progression through meiotic cell cycle
negative regulation of meiotic cell cycle progression
negative regulation of progression through meiotic cell cycle
inhibition of progression through meiotic cell cycle
negative regulation of meiotic cell cycle
The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus.
maintenance of nuclear protein localization
maintenance of protein location in cell nucleus
maintenance of protein localization in nucleus
maintenance of protein location in nucleus
The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole.
heterotypic vacuole fusion (non-autophagic)
heterotypic vacuole fusion, non-autophagic
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.
regulation of cytoskeleton organization and biogenesis
Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.
down regulation of cytoskeleton organization
down-regulation of cytoskeleton organization
downregulation of cytoskeleton organization
negative regulation of cytoskeleton organisation
negative regulation of cytoskeleton organization and biogenesis
negative regulation of cytoskeleton organization
Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.
positive regulation of cytoskeleton organisation
up regulation of cytoskeleton organization
up-regulation of cytoskeleton organization
upregulation of cytoskeleton organization
stimulation of cytoskeleton organization
positive regulation of cytoskeleton organization and biogenesis
positive regulation of cytoskeleton organization
Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of neurotransmitter transport
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
down regulation of neurotransmitter transport
down-regulation of neurotransmitter transport
downregulation of neurotransmitter transport
inhibition of neurotransmitter transport
negative regulation of neurotransmitter transport
Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
up regulation of neurotransmitter transport
up-regulation of neurotransmitter transport
upregulation of neurotransmitter transport
activation of neurotransmitter transport
stimulation of neurotransmitter transport
positive regulation of neurotransmitter transport
The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal.
The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.
Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell.
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell.
down regulation of norepinephrine uptake
down-regulation of norepinephrine uptake
negative regulation of levarterenol uptake
negative regulation of noradrenaline uptake
negative regulation of norepinephrine import
negative regulation of norepinephrine uptake
Any process that activates or increases the frequency, rate or extent of the directed movement of norepinephrine into a cell.
positive regulation of levarterenol uptake
positive regulation of noradrenaline uptake
positive regulation of norepinephrine import
positive regulation of norepinephrine uptake
The directed movement of acetylcholine into a cell, typically presynaptic neurons or glial cells. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues.
Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter acetylcholine into a cell.
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of acetylcholine into a cell.
negative regulation of acetylcholine import
negative regulation of acetylcholine uptake
Any process that activates or increases the frequency, rate or extent of the directed movement of acetylcholine into a cell.
positive regulation of acetylcholine import
positive regulation of acetylcholine uptake
Any process in which an organelle is transported to, and/or maintained in, a specific location.
establishment and maintenance of organelle localization
A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane.
establishment and maintenance of cellular localization
establishment and maintenance of localization in cell or cell membrane
Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell.
establishment and maintenance of Golgi localization
Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell.
establishment and maintenance of nucleus localization
Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location.
establishment and maintenance of vesicle localization
Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.
establishment of intracellular localization
establishment of localization within cell
The directed movement of a vesicle to a specific location.
Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere.
maintenance of intracellular localization
Any process in which a chromosome is maintained in a specific location within a cell and prevented from moving elsewhere.
Any process in which a vesicle is maintained in a specific location within a cell and prevented from moving elsewhere.
The directed movement of an organelle to a specific location.
Any process in which an organelle is maintained in a specific location within a cell and prevented from moving elsewhere.
Any process in which the nucleus is maintained in a specific location within a cell and prevented from moving elsewhere.
Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane.
establishment and maintenance of localization in membrane
establishment and maintenance of position in membrane
Any process in which a cell is transported to, and/or maintained in, a specific location.
establishment and maintenance of cell localization
establishment and maintenance of localization of cell
The directed movement of the Golgi to a specific location.
establishment of Golgi apparatus localization
establishment of Golgi body localization
Any process in which the Golgi is maintained in a specific location within a cell and prevented from moving elsewhere.
maintenance of Golgi apparatus localization
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism.
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell.
Any process that modulates the rate or extent of progression through the cell cycle.
regulation of progression through cell cycle
arrest of mitotic cell cycle progression
negative regulation of cell cycle arrest
positive regulation of cell cycle arrest
Energy dependent regulation of mTOR by LKB1-AMPK
Any process that activates or increases the frequency, rate or extent of cell division.
Any process that stops, prevents, or reduces the frequency, rate or extent of cell division.
Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.
Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.
Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.
Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell.
Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
regulation of cardioblast differentiation
Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
up regulation of cardioblast differentiation
up-regulation of cardioblast differentiation
upregulation of cardioblast differentiation
activation of cardioblast differentiation
stimulation of cardioblast differentiation
positive regulation of cardioblast differentiation
Any process that stops, prevents, or reduces the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
down regulation of cardioblast differentiation
down-regulation of cardioblast differentiation
downregulation of cardioblast differentiation
inhibition of cardioblast differentiation
negative regulation of cardioblast differentiation
The directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
The directed movement of a pigment granule to a specific location.
establishment of pigment granule localisation
establishment of pigment granule localization
Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal.
regulation of sensory perception of pain
Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal.
The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.
Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
negative regulation of amino acid transmembrane transport
negative regulation of amino acid transport
Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
positive regulation of amino acid transmembrane transport
positive regulation of amino acid transport
Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue.
regulation of nervous system development
Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue.
down regulation of nervous system development
down-regulation of nervous system development
downregulation of nervous system development
inhibition of nervous system development
negative regulation of nervous system development
Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue.
up regulation of nervous system development
up-regulation of nervous system development
upregulation of nervous system development
activation of nervous system development
stimulation of nervous system development
positive regulation of nervous system development
Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
negative regulation of synapse biogenesis
Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
positive regulation of synapse biogenesis
Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.
regulation of conduction of nerve impulse
regulation of transmission of nerve impulse
Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.
down regulation of transmission of nerve impulse
down-regulation of transmission of nerve impulse
downregulation of transmission of nerve impulse
negative regulation of conduction of nerve impulse
inhibition of transmission of nerve impulse
negative regulation of transmission of nerve impulse
Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.
positive regulation of conduction of nerve impulse
up regulation of transmission of nerve impulse
up-regulation of transmission of nerve impulse
upregulation of transmission of nerve impulse
activation of transmission of nerve impulse
stimulation of transmission of nerve impulse
positive regulation of transmission of nerve impulse
Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.
Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.
positive regulation of chromosome segregation
Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.
down regulation of chromosome segregation
down-regulation of chromosome segregation
downregulation of chromosome segregation
negative regulation of chromosome segregation
The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate.
The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle.
The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells.
The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual.
The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
The process in which the anatomical structures of cardiac muscle tissue are generated and organized.
The process in which the anatomical structure of cardiac atrium muscle is generated and organized.
atrial cardiac muscle tissue morphogenesis
The process in which the anatomical structures of cardiac ventricle muscle is generated and organized.
ventricular cardiac muscle tissue morphogenesis
The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state.
The increase in size or mass of a cardiac muscle, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.
Any process that modulates the frequency, rate or extent of cardiac muscle fiber development.
regulation of cardiac muscle fibre development
regulation of heart muscle fiber development
regulation of cardiac muscle fiber development
Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle fiber development.
down regulation of cardiac muscle fiber development
down-regulation of cardiac muscle fiber development
downregulation of cardiac muscle fiber development
negative regulation of cardiac muscle fibre development
inhibition of cardiac muscle fiber development
negative regulation of heart muscle fiber development
negative regulation of cardiac muscle fiber development
Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle fiber development.
positive regulation of cardiac muscle fibre development
positive regulation of heart muscle fiber development
up regulation of cardiac muscle fiber development
up-regulation of cardiac muscle fiber development
upregulation of cardiac muscle fiber development
activation of cardiac muscle fiber development
stimulation of cardiac muscle fiber development
positive regulation of cardiac muscle fiber development
Any process that modulates the frequency, rate or extent of cardiac muscle growth.
regulation of cardiac muscle tissue growth
Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth.
down regulation of cardiac muscle growth
down-regulation of cardiac muscle growth
negative regulation of heart muscle growth
negative regulation of cardiac muscle tissue growth
Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle growth.
positive regulation of heart muscle growth
positive regulation of cardiac muscle tissue growth
Any process that modulates the frequency, rate or extent of cardiac muscle tissue development.
regulation of cardiac muscle tissue development
Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development.
positive regulation of heart muscle development
up regulation of cardiac muscle development
up-regulation of cardiac muscle development
upregulation of cardiac muscle development
activation of cardiac muscle development
stimulation of cardiac muscle development
positive regulation of cardiac muscle tissue development
Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development.
down regulation of cardiac muscle development
down-regulation of cardiac muscle development
downregulation of cardiac muscle development
negative regulation of heart muscle development
inhibition of cardiac muscle development
negative regulation of cardiac muscle tissue development
The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron.
The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials.
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
ATP hydrolysis coupled transmembrane transport
Transmembrane transport is the transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes.
Miscellaneous transport and binding events
The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide.
nucleobase, nucleoside and nucleotide metabolism
nucleobase-containing small molecule metabolic process
Phosphate bond hydrolysis by NUDT proteins
The directed movement of proteins from the Golgi to a secretory granule. The secretory granule is a membrane-bounded particle, usually protein, formed in the granular endoplasmic reticulum and the Golgi complex.
The directed movement of proteins from the Golgi to a transport vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis.
Any process that modulates the frequency, rate or extent of cardiac muscle contraction.
regulation of cardiac muscle contraction
Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction.
negative regulation of cardiac muscle contraction
The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the structure it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear.
The expansion of a cardiac muscle cell population by cell division.
The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery.
The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
The process in which the anatomical structure of the retina is generated and organized.
retina morphogenesis in camera-style eye
Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation.
regulation of heart muscle cell proliferation
regulation of cardiomyocyte proliferation
regulation of cardiac muscle cell proliferation
Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation.
negative regulation of heart muscle cell proliferation
negative regulation of cardiac muscle cell proliferation
Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation.
positive regulation of heart muscle cell proliferation
positive regulation of cardiac muscle cell proliferation
The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body.
Muscle contraction of cardiac muscle tissue.
The regulated release of serotonin by a cell, in which released serotonin acts as a neurotransmitter.
A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother.
embryonic process involved in female pregnancy
Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.
regulation of syncytium formation by plasma membrane fusion
Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.
positive regulation of syncytium formation by plasma membrane fusion
The portion of the plasma membrane surrounding a cilium.
The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin.
Formation of the endocardium of the heart. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.
The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
haematopoietic stem cell differentiation
The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye.
camera-type eye photoreceptor cell differentiation
The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell.
A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell.
epithelial cell differentiation from mesenchymal cell
Any process that modulates the frequency, rate or extent of glial cell proliferation.
Any process that activates or increases the rate or extent of glial cell proliferation.
positive regulation of glial cell proliferation
Any process that stops or decreases the rate or extent of glial cell proliferation.
negative regulation of glial cell proliferation
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
regulation of macromolecule metabolic process
The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
positive regulation of oocyte development
Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
negative regulation of oocyte development
Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
microtubule-based flagellar cell motility
Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent.
Movement of cilia mediated by motor proteins that contributes to the movement of a cell.
cilium movement involved in cell motility
Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility.
regulation of cilium movement involved in cell motility
Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
positive regulation of sarcomere organisation
positive regulation of sarcomere organization
Any process that decreases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
negative regulation of sarcomere organisation
negative regulation of sarcomere organization
The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body.
The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body.
The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head.
The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head.
Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell.
The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.
The process in which bones are generated and organized.
The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone.
The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones.
cartilage development involved in endochondral bone morphogenesis
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus.
Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement.
The process in which any suture between cranial bones is generated and organized.
The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life.
myocardial precursor cell differentiation
cardiac muscle cell myoblast differentiation
The removal of tubulin heterodimers from one or both ends of an axonemal microtubule. An axonemal microtubule is a microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules.
Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues.
regulation of acetylcholine metabolic process
Any process that increases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues.
positive regulation of acetylcholine metabolic process
Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues.
negative regulation of acetylcholine metabolic process
The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart.
The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another.
The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another.
The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body.
aorta smooth muscle tissue morphogenesis
The process in which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function.
The increase in size or mass of the heart.
Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart.
Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart.
The process in which the anatomical structures of the lung are generated and organized.
The biological process whose specific outcome is the progression of a lung vasculature from an initial condition to its mature state. This process begins with the formation of the lung vasculature and ends with the mature structure. The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs.
The biological process whose specific outcome is the progression of lung connective tissue from an initial condition to its mature state. This process begins with the formation of lung connective tissue and ends with the mature structure. The lung connective tissue is a material made up of fibers forming a framework and support structure for the lungs.
The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung.
The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.
The morphogenetic process in which the foregut region specified to become the lung forms the initial left and right buds.
The biological process whose specific outcome is the progression of a bronchus from an initial condition to its mature state. This process begins with the formation of the bronchus and ends with the mature structure. The bronchus is the portion of the airway that connects to the lungs.
The process in which the bronchus is generated and organized. The bronchus is the portion of the airway that connects to the lungs.
The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.
The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches.
The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches.
The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches.
The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.
epithelial tube branching involved in lung morphogenesis
Any process that increases the frequency, rate or extent of cardiac muscle contraction.
positive regulation of cardiac muscle contraction
Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.
Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.
positive regulation of gastric acid secretion
Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.
negative regulation of gastric acid secretion
Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
positive regulation of digestive system process
Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
negative regulation of digestive system process
The biological process whose specific outcome is the progression of a right lung from an initial condition to its mature state. This process begins with the formation of the right lung and ends with the mature structure. The right lung is the lung which is on the right side of the anterior posterior axis looking from a dorsal to ventral aspect.
The biological process whose specific outcome is the progression of a left lung from an initial condition to its mature state. This process begins with the formation of the left lung and ends with the mature structure. The left lung is the lung which is on the left side of the anterior posterior axis looking from a dorsal to ventral aspect.
The process in which anatomical structures of the left lung are generated and organized.
The process in which anatomical structures of the right lung are generated and organized.
The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth.
Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).
The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg.
negative regulation of fertilization involved in egg activation
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate.
The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells.
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung.
pulmonary epithelial cell differentiation
Any process that modulates the rate, frequency, or extent of cell projection assembly.
Any process that mediates the transfer of information from one cell to another and contributes to the progression of the lung, from its initial state to the mature structure.
cell-cell signalling involved in lung development
cell-cell signaling involved in lung development
Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell and contributes to the development of the lung.
mesenchymal-epithelial cell signalling involved in lung development
mesenchymal-epithelial cell signaling involved in lung development
Any process that mediates the transfer of information between a mesenchymal cell and an endodermal cell.
Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape.
positive regulation of epithelial cell proliferation involved in lung morphogenesis
The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung.
epithelial cell proliferation involved in lung morphogenesis
The process whose specific outcome is the progression of lung cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
The process in which the bronchus cartilage is generated and organized. The bronchus cartilage is the connective tissue of the portion of the airway that connects to the lungs.
The process whose specific outcome is the progression of the tracheal cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
The process in which the anatomical structures of cartilage in the trachea are generated and organized.
The process in which the anatomical structures of cartilage are generated and organized.
The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers.
The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue.
The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs.
The process in which the anatomical structures of the diaphragm are generated and organized.
The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange.
The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape.
developmental growth involved in morphogenesis
Any apoptotic process that contributes to the shaping of an anatomical structure.
apoptotic process involved in morphogenesis
The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.
The process in which epiblast cells acquire specialized features of neuroepithelial cells.
The morphogenetic process in which an epithelial sheet bends along a linear axis.
The morphogenetic process in which a bud forms from an epithelial sheet. A bud is a protrusion that forms form the sheet by localized folding.
The process in which the anatomical structure of the pulmonary venous blood vessels are generated and organized. Pulmonary veins are blood vessels that transport blood from the lungs to the heart.
pulmonary venous blood vessel morphogenesis
The process in which the anatomical structure of superior vena cava generated and organized. The superior vena cava is a blood vessel that transports blood from the upper body to the heart.
The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type.
cell fate commitment involved in pattern specification
The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes.
chondrocyte progenitor cell differentiation
The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat.
Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.
Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.
regulation of vesicle-mediated transport
Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins.
regulation of microtubule-based movement
Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted.
Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted.
Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized.
regulation of morphogenesis of a branching structure
The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm.
The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation.
cell fate commitment involved in formation of primary germ layer
The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels.
blood vessel endothelial cell differentiation
The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed.
The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed.
The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries.
arterial endothelial cell differentiation
The process in which a relatively unspecialized endothelial cell acquires specialized features of a venous endothelial cell, a thin flattened cell that lines the inside surfaces of veins.
The developmental process that results in the creation of defined areas or spaces within the neural plate to which cells respond and eventually are instructed to differentiate.
Specification of the neural plate border
The pattern specification process that results in the subdivision of an axis or axes of the neural plate in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.
The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape.
The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable.
The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the lung. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.
mesenchymal cell differentiation involved in lung development
The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.
mesenchymal cell proliferation involved in lung development
The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions.
The process in which a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node.
The process in which a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node.
atrioventricular node cell differentiation
The process whose specific outcome is the progression of a pacemaker cell over time, from its formation to the mature state. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions.
The process whose specific outcome is the progression of an atrioventricular (AV) node cell over time, from its formation to the mature state.
The process whose specific outcome is the progression of a sinoatrial (SA) node cell over time, from its formation to the mature state. SA node cells are pacemaker cells that are found in the sinoatrial node.
The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the His-Purkinje system. These cells form the fibers regulate cardiac muscle contraction in the ventricles.
His-Purkinje system cell differentiation
The process whose specific outcome is the progression of a His-Purkinje cell over time, from its formation to the mature state. These cells form the fibers that regulate cardiac muscle contraction in the ventricles.
The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules.
The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules.
The process in which a relatively unspecialized cell acquires specialized features of a neuron of the heart.
The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell of the heart. Blood vessel endothelial cells are thin flattened cells that line the inside surfaces of blood vessels.
cardiac blood vessel endothelial cell differentiation
The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the heart.
The process aimed at the progression of a cardiac glial cell over time, from its formation to the fully functional mature cell.
The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers.
The progression of an endocardial cell over time, from its formation to the mature cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart.
The process whose specific outcome is the progression of a cardiac neuron over time, from its formation to the mature state.
The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ.
cell migration involved in heart development
The orderly movement of a cell from one site to another that contribute to the formation of the heart. The initial heart structure is made up of mesoderm-derived heart progenitor cells and neural crest-derived cells.
cell migration involved in heart formation
The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure.
The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood.
Blood vessel formation in the heart when new vessels emerge from the proliferation of pre-existing blood vessels.
angiogenesis involved in cardiac vascular morphogenesis
angiogenesis involved in heart vascular morphogenesis
angiogenesis involved in coronary vascular morphogenesis
The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes.
vasculogenesis involved in coronary blood vessel morphogenesis
vasculogenesis involved in coronary vascular morphogenesis
The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form the blood vessels of the heart.
cell migration involved in coronary vasculogenesis
The orderly movement of a cell from one site to another that will contribute to the formation of new blood vessels in the heart from pre-existing blood vessels.
cell migration involved in coronary angiogenesis
The regulated release of a hormone into the circulatory system.
The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
Any process that modulates the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.
regulation of dendritic spine development
Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.
positive regulation of dendritic spine development
Any process that decreases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.
negative regulation of dendritic spine development
Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
regulation of dendritic spine morphogenesis
Any process that decreases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
negative regulation of dendritic spine morphogenesis
Any process that increases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
positive regulation of dendritic spine morphogenesis
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
The membrane organization process that joins two lipid bilayers to form a single membrane.
The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium.
Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
positive regulation of cartilage development
Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
negative regulation of cartilage development
The process in which a female gonad is generated and organized.
Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.
regulation of branching involved in lung morphogenesis
Any process that increases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.
positive regulation of branching involved in lung morphogenesis
Any process that decreases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.
negative regulation of branching involved in lung morphogenesis
The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.
cell growth involved in cardiac muscle cell development
Any process that modulates the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.
regulation of cell growth involved in cardiac muscle cell development
Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.
positive regulation of cell growth involved in cardiac muscle cell development
Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.
negative regulation of cell growth involved in cardiac muscle cell development
The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
The progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin.
The progression of the myotome over time, from its formation to the mature structure. The myotome is the portion of the somite that will give rise to muscle.
The progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra.
The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms.
The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina.
The process in which the ciliary body generated and organized. The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes.
Any process that modulates the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.
Any process that increases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.
positive regulation of neural retina development
Any process that decreases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.
negative regulation of neural retina development
The progression of the right horn of the sinus venosus from its formation to the mature structure.
The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium.
lung neuroendocrine cell differentiation
The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance.
The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the stomach epithelium.
gastric neuroendocrine cell differentiation
stomach neuroendocrine cell differentiation
Any process that modulates the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach.
regulation of stomach neuroendocrine cell differentiation
Any process that decreases the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach.
negative regulation of stomach neuroendocrine cell differentiation
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dense core granule. A dense core granule is a secretory organelle found in endocrine cells.
Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell and contributes to the progression of the lung over time from its initial formation to the mature organ.
epithelial-mesenchymal cell signalling involved in lung development
epithelial-mesenchymal cell signaling involved in lung development
Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart.
The process in which the anatomical structures of a branched epithelium are generated and organized.
The process in which a relatively unspecialized cell acquires specialized features of a lung secretory cell. A lung secretory cell is a specialized epithelial cell of the lung that contains large secretory granules in its apical part.
The process in which a relatively unspecialized cell acquires specialized features of a lung ciliated cell. A lung ciliated cell is a specialized lung epithelial cell that contains cilia for moving substances released from lung secretory cells.
The progression of the endocardial endothelium over time, from its initial formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.
A process which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix of the endocardium. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.
extracellular matrix organisation involved in endocardium development
extracellular matrix organization involved in endocardium development
The progression of the trachea submucosa over time from its formation to the mature structure. The trachea submucosa is made up of the glands and elastic tissue that lie under the mucosa in the trachea.
The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.
The process in which the anatomical structures of a tube are generated and organized from the pulmonary artery endothelium. An pulmonary artery endothelium is an epithelium that lines the pulmonary artery.
pulmonary artery endothelial tube morphogenesis
The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs.
Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.
Any process that decreases the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.
negative regulation of chondrocyte development
Any process that modulates the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin.
Any process that increases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin.
positive regulation of dermatome development
Any process that decreases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin.
negative regulation of dermatome development
Any process that increases the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra.
positive regulation of sclerotome development
Any process that modulates the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra.
The progression of the taste bud over time, from its formation to the mature state. The taste bud is a specialized area of the tongue that contains taste receptors.
The process in which the anatomical structures of the taste bud are generated and organized. The taste bud is a specialized area of the tongue that contains taste receptors.
The developmental process pertaining to the initial formation of the taste bud from unspecified parts. The taste bud is a specialized area of the tongue that contains taste receptors.
The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure.
retina vasculature development in camera-type eye
The process in which the vasculature of the retina is generated and organized.
retina vasculature morphogenesis in camera-type eye
The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye.
The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure.
The process in which a relatively unspecialized cell acquires specialized features of a cardiac neural crest cell that will migrate to the heart and contribute to its development. Cardiac neural crest cells are specialized cells that migrate toward the heart from the third, fourth and sixth pharyngeal arches.
cardiac neural crest cell differentiation involved in heart development
The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the development of the heart.
cardiac neural crest cell development involved in heart development
The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract.
cardiac neural crest cell development involved in outflow tract morphogenesis
The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart.
cell proliferation involved in heart morphogenesis
The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the outflow tract.
cell proliferation involved in outflow tract morphogenesis
Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles.
The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell.
The multiplication or reproduction of fibroblasts, resulting in the expansion of a fibroblast population that contributes to the shaping of the heart.
fibroblast proliferation involved in heart morphogenesis
The progression of a connective tissue over time, from its formation to the mature structure.
Trophoblast cell migration that is accomplished by extension and retraction of a pseudopodium. Trophoblast cells line the outside of the blastocyst.
The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction.
Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells.
A process in which a protein is transported to, or maintained in, a location within a cilium.
The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure.
A cellular process that results in the breakdown of a cilium.
The regulated release of acetylcholine by a cell.
The regulated release of norepinephrine by a cell, in which the norepinephrine acts as a neurotransmitter.
noradrenaline secretion, neurotransmission
norepinephrine secretion, neurotransmission
The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure.
The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure.
The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure.
The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure.
The process in which the anatomical structures of ganglion are generated and organized.
A developmental process, independent of morphogenetic (shape) change, that is required for ganglion to attain its fully functional state.
The process that gives rise to ganglion. This process pertains to the initial formation of a structure from unspecified parts.
The process in which the anatomical structure of a trigeminal ganglion is generated and organized.
A developmental process, independent of morphogenetic (shape) change, that is required for a trigeminal ganglion to attain its fully functional state.
A developmental process, independent of morphogenetic (shape) change, that is required for a cranial ganglion to attain its fully functional state.
The process in which the anatomical structure of a cranial ganglion is generated and organized.
The process that gives rise to a cranial ganglion. This process pertains to the initial formation of a structure from unspecified parts.
The process that gives rise to the trigeminal ganglion. This process pertains to the initial formation of a structure from unspecified parts.
The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation).
The orderly movement of a corneal epithelial cell from one site to another, often during the development of a multicellular organism.
The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery.
Steps required to transform an immature secretory vesicle into a mature secretory vesicle. Typically proceeds through homotypic membrane fusion and membrane remodeling.
Any process in which the microtubule organizing center is transported to, and/or maintained in, a specific location within the cell.
microtubule organizing center localization
The region of the neuronal cytoplasm located in dendritic spines.
Any process that modulates the frequency, rate or extent of neuroblast migration.
Any process that activates or increases the frequency, rate or extent of neuroblast migration.
positive regulation of neuroblast migration
Any process that stops, prevents, or reduces the frequency, rate or extent of neuroblast migration.
negative regulation of neuroblast migration
A change in morphology and behavior of a glial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
A process in which a protein is transported to or maintained in a location within the somatodendritic compartment.
protein localization to somatodendritic compartment
The directed movement of a protein to a specific location in a plasma membrane.
establishment of protein localization to plasma membrane
The process in which bones are generated and organized as a result of the conversion of another structural tissue into bone.
The process in which bone which forms superficially in the organism are generated and organized.
The process in which bone which forms deep in the organism are generated and organized.
Any process that modulates the rate, frequency or extent of a small molecule metabolic process.
regulation of small molecule metabolic process
Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process.
positive regulation of small molecule metabolism
positive regulation of small molecule metabolic process
Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process.
negative regulation of small molecule metabolism
negative regulation of small molecule metabolic process
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
collagen-containing extracellular matrix
Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis.
positive regulation of mitotic sister chromatid segregation
The process whose specific outcome is the progression of the stomach over time, from its formation to the mature structure. The stomach is an expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ.
The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal.
detection of stimulus involved in sensory perception of pain
Any process in which a protein is transported to, and/or maintained at the postsynapse, the part of a synapse that is part of the post-synaptic cell.
The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.
intracellular membrane translocation of a protein
intracellular protein membrane transport
intracellular protein transport across a membrane
intracellular protein transmembrane transport
The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
cellular protein-containing complex assembly
Any process that modulates a measurable attribute of any biological process, quality or function.
Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.
Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell.
extracellular membrane-enclosed organelle
extracellular membrane-bounded organelle
An organelle lumen that is part of an intracellular organelle.
The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state.
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans).
Any process that modulates the frequency, rate or extent of the regulated release of glucagon.
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon.
negative regulation of glucagon secretion
Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon.
positive regulation of glucagon secretion
A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
A process of chromosome organization that is involved in a meiotic cell cycle.
chromosome organisation involved in meiosis
chromosome organization involved in meiotic cell cycle
The directed movement of a protein to a specific location on a chromosome.
establishment of protein localisation to chromosome
establishment of protein localization to chromosome
Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location.
regulation of establishment of protein localisation
regulation of establishment of protein localization
Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome.
regulation of establishment of protein localisation to chromosome
regulation of establishment of protein localization to chromosome
Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.
Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).
Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process.
regulation of lymphocyte apoptotic process
Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process.
negative regulation of lymphocyte apoptosis
negative regulation of lymphocyte apoptotic process
Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process.
positive regulation of lymphocyte apoptosis
positive regulation of lymphocyte apoptotic process
The regulated release of somatostatin from secretory granules in the D cells of the pancreas.
The controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell.
extracellular matrix constituent secretion
The process whose specific outcome is the progression of a pigment cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a pigment cell fate.
The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat.
Any process that modulates the frequency, rate or extent of fat cell proliferation.
regulation of adipose cell proliferation
Any process that stops or decreases the rate or extent of fat cell proliferation.
down regulation of fat cell proliferation
down-regulation of fat cell proliferation
downregulation of fat cell proliferation
negative regulation of adipocyte proliferation
negative regulation of adipose cell proliferation
negative regulation of fat cell proliferation
Any process that activates or increases the rate or extent of fat cell proliferation.
positive regulation of adipocyte proliferation
positive regulation of adipose cell proliferation
positive regulation of fat cell proliferation
A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis.
exocytic constitutive secretory pathway transport vesicle
The multiplication or reproduction of oligodendrocyte progenitor cells by cell division, resulting in the expansion of their population. Oligodendrocyte progenitors give rise to oligodendrocytes, which form the insulating myelin sheath of axons in the central nervous system.
oligodendrocyte progenitor proliferation
Any process that modulates the frequency, rate or extent of oligodendrocyte progenitor proliferation.
regulation of oligodendrocyte precursor proliferation
regulation of oligodendrocyte progenitor proliferation
Any process that stops or decreases the rate or extent of oligodendrocyte progenitor proliferation.
negative regulation of oligodendrocyte precursor proliferation
negative regulation of oligodendrocyte progenitor proliferation
Any process that activates or increases the rate or extent of oligodendrocyte progenitor proliferation.
positive regulation of oligodendrocyte precursor proliferation
positive regulation of oligodendrocyte progenitor proliferation
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.
The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
regulation of microtubule cytoskeleton organisation
regulation of microtubule cytoskeleton organization
The directed movement of a substance from one side of an epithelium to the other.
The directed movement of ammonium ions from one side of an epithelium to the other.
The expansion of a leukocyte population by cell division.
Any process that modulates the frequency, rate or extent of leukocyte proliferation.
Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation.
down regulation of leukocyte proliferation
down-regulation of leukocyte proliferation
downregulation of leukocyte proliferation
negative regulation of leukocyte proliferation
Any process that activates or increases the frequency, rate or extent of leukocyte proliferation.
up regulation of leukocyte proliferation
up-regulation of leukocyte proliferation
positive regulation of leukocyte proliferation
Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue.
Note that this term has no relationship to 'membrane assembly ; GO:0071709' because the basement membrane is not a lipid bilayer.
The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state.
Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin.
The directed movement of a protein to a part of a chromosome that is organized into chromatin.
establishment of protein localisation to chromatin
establishment of protein localization to chromatin
The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop.
The process of biting and mashing food with the teeth prior to swallowing.
The movement of a mononuclear cell within or between different tissues and organs of the body.
Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body.
regulation of mononuclear cell migration
Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body.
down regulation of mononuclear cell migration
down-regulation of mononuclear cell migration
downregulation of mononuclear cell migration
inhibition of mononuclear cell migration
negative regulation of mononuclear cell migration
Any process that increases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body.
up regulation of mononuclear cell migration
up-regulation of mononuclear cell migration
upregulation of mononuclear cell migration
activation of mononuclear cell migration
stimulation of mononuclear cell migration
positive regulation of mononuclear cell migration
Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location.
protein localisation in extracellular region
protein localization in extracellular region
protein localization to extracellular region
A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state.
The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm.
The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm.
The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
The aggregation, arrangement and bonding together of a set of components to form a membrane.
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane.
Note that this term has no relationship to 'membrane organization ; GO:0061024' because the basement membrane is not a lipid bilayer.
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane.
nuclear membrane organization and biogenesis
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear outer membrane.
nuclear outer membrane organization and biogenesis
The process in which a protein is transported across a membrane.
Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex.
RNA-protein complex subunit organization
protein-RNA complex subunit organization
ribonucleoprotein complex subunit organisation
ribonucleoprotein complex subunit organization
A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component.
cellular component organisation or biogenesis
cellular component organisation or biogenesis at cellular level
cellular component organization or biogenesis at cellular level
cellular component organization or biogenesis
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan.
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution.
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system.
Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors.
Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.
The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures.
An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain.
The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Exosomes are defined by their size, which generally ranges from 30 nm to 100 nm.
extracellular vesicular exosome assembly
The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells.
The developmental process pertaining to the initial formation of an epithelial tube.
Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.
negative regulation of mesenchymal cell proliferation
The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group.
monocarboxylic acid biosynthetic process
The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.
The progression of the vascular cord over time from its initial formation until its mature state. The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis.
The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination.
microtubule-based organelle localization
The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+.
A change in the morphology or behavior of a fibroblast resulting from exposure to an activating factor such as a cellular or soluble ligand.
Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal.
endothelial cell programmed cell death by apoptosis
programmed cell death of endothelial cells by apoptosis
programmed cell death, endothelial cells
The chemical reactions and pathways involving diatomic oxygen (O2).
The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle.
establishment of protein localisation to organelle
establishment of protein localization to organelle
Any process in which a protein is maintained in a specific location a specific location on or in an organelle, and is prevented from moving elsewhere. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle.
maintenance of protein localisation to organelle
maintenance of protein localization to organelle
maintenance of protein localization in organelle
A process in which a protein is transported to, or maintained in, a specific location in a membrane.
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
A process in which a protein is transported to, or maintained at, a location in a vacuole.
The directed movement of a protein to a specific location in a vacuole.
establishment of protein localisation to vacuole
establishment of protein localization to vacuole
Any process in which a protein is maintained in a specific location in a vacuole, and is prevented from moving elsewhere.
maintenance of protein location in vacuole
The movement of a lymphocyte within or between different tissues and organs of the body.
A process in which a protein is transported to, or maintained in, the cell cortex.
A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton.
protein localisation to microtubule cytoskeleton
protein localization to microtubule cytoskeleton
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).
The aggregation, arrangement and bonding together of the extracellular matrix.
An action potential that occurs in a cardiac muscle cell.
An action potential that occurs in a sinoatrial node cardiac muscle cell.
SA node cardiac muscle cell action potential
SAN cardiac muscle cell action potential
sinoatrial node cardiac muscle cell action potential
sinus node cardiac muscle cell action potential
An action potential that occurs in an atrioventricular node cardiac muscle cell.
AV node cardiac muscle cell action potential
atrioventricular node cardiac muscle cell action potential
An action potential that occurs in a Purkinje myocyte.
Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte.
SA node cardiac muscle cell to atrial cardiac muscle cell signalling
SA node cardiomyocyte to atrial cardiomyocyte signalling
SAN cardiomyocyte to atrial cardiomyocyte signalling
sinoatrial node cardiomyocyte to atrial cardiomyocyte signalling
sinus node cardiomyocyte to atrial cardiomyocyte signalling
SA node cell to atrial cardiac muscle cell signaling
Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium.
cell-cell signalling involved in cardiac conduction
cell-cell signaling involved in cardiac conduction
Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte.
AV node cell to bundle of His cell signalling
atrioventricular node to bundle of His cell signaling
AV node cell to bundle of His cell signaling
Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell.
Purkinje myocyte to ventricular cardiac muscle cell signalling
Purkinje myocyte to ventricular cardiac muscle cell signaling
Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
cell communication involved in cardiac conduction
The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
atrioventricular node cell to bundle of His cell communication
AV node cell to bundle of His cell communication
The process that mediates interactions between a Purkinje myocyte and its surroundings that contributes to the process of the Purkinje myocyte communicating with a ventricular cardiac muscle cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
Purkinje myocyte to ventricular cardiac muscle cell communication
The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
SA node cardiac muscle cell to atrial cardiac muscle cell communication
SA node cardiomyocyte to atrial cardiomyocyte communication
SAN cardiomyocyte to atrial cardiomyocyte communication
sinoatrial node cardiomyocyte to atrial cardiomyocyte communication
sinus node cardiomyocyte to atrial cardiomyocyte communication
SA node cell to atrial cardiac muscle cell communication
The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol.
amino acid import across plasma membrane
Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell.
positive regulation of microtubule nucleation
Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
positive regulation of cell cycle process
Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.
Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.
positive regulation of ribosome biogenesis
Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.
negative regulation of ribosome biogenesis
Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.
positive regulation of extracellular matrix disassembly
The process in which the population of cells that make up a tissue undergo directed movement.
The process in which the population of cells that make up an epithelium undergo directed movement.
The directed movement of a protein to a specific location in a membrane.
establishment of protein localisation in membrane
establishment of protein localization in membrane
establishment of protein localization to membrane
The specification and formation of anisotropic intracellular organization of an epithelial cell.
establishment of epithelial cell polarity
A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance.
The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance.
Any process that modulates the rate, frequency or extent of Golgi inheritance. Golgi inheritance is the partitioning of Golgi apparatus between daughter cells at cell division.
The process in which the structures of a chondrocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a chondrocyte.
The joining of two lipid bilayers to form a single organelle membrane.
Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system.
Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.
Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.
positive regulation of somatostatin secretion
Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.
negative regulation of somatostatin secretion
Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.
Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.
positive regulation of peptide hormone secretion
Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.
negative regulation of peptide hormone secretion
Any process that modulates the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds.
Any process that increases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds.
positive regulation of neural crest formation
Any process that decreases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds.
negative regulation of neural crest formation
Any cellular metabolic process involving nucleic acids.
Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells.
positive regulation of intracellular protein transport
Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells.
negative regulation of intracellular protein transport
The epithelial cell differentiation process in which a relatively unspecialized cell acquires specialized features of an acinar cell, a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini.
A process in which a protein is transported to, or maintained at, a location within a nuclear envelope.
protein localization in nuclear envelope
protein localization to nuclear envelope
The directed movement of catecholamine into a cell.
The orderly movement of a mesenchymal cell from one site to another, often during the development of a multicellular organism.
Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus.
Any membrane that is part of a pigment granule.
All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
Note that we deem cilium and microtubule-based flagellum to be equivalent. Also, researchers consider the composition of both the plasm and the membrane of the cilium to be detectably different from that in the non-ciliary cytosol and plasma membrane (e.g. in terms of calcium ion concentration, membrane lipid composition, and more). For this reason, the term "ciliary plasm" is not linked to "cytoplasm".
Any apoptotic process in a motor neuron, an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement.
A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dendritic spine. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission.
The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels.
vascular associated smooth muscle cell development
The process in which any suture between cranial and/or facial bones is generated and organized.
The process in which any suture between facial bones is generated and organized.
Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.
The chemical reactions and pathways involving the ammonium ion.
The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.
induction of apoptosis by extracellular signals
This term can be used to annotate gene products involved in apoptotic events happening downstream of the cross-talk point between the extrinsic and intrinsic apoptotic pathways. The cross-talk starts when caspase-8 cleaves Bid and truncated Bid interacts with mitochondria. From this point on it is not possible to distinguish between extrinsic and intrinsic pathways.
Cell death signalling via NRAGE, NRIF and NADE
A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
Any apoptotic process in an oligodendrocyte. Oligodendrocytes belong to a class of large neuroglial (macroglial) cells in the central nervous system, where they form the insulating myelin sheath of axons.
Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into heterochromatin.
A prolongation or process extending from a glial cell.
The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron.
An arrangement of closely apposed microtubules running parallel to each other.
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure.
extracellular fibril organization and biogenesis
The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches.
Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina.
Any apoptotic process in a retinal cone cell, one of the two photoreceptor cell types of the vertebrate retina.
The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement.
The orderly movement of a spinal cord motor neuron from one site to another. A spinal cord motor neuron is a motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement.
A cardiac myofibril is a myofibril specific to cardiac muscle cells.
The movement of a myeloid leukocyte within or between different tissues and organs of the body.
The orderly movement of a lymphoid lineage cell from one site to another. A lymphoid lineage cell, also called a lymphoid lineage restricted progenitor cell, is a progenitor cell restricted to the lymphoid lineage.
lymphoid lineage restricted progenitor cell migration
Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole.
Any vesicle that is part of the intracellular region.
The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane.
anchoring of the basal body to the plasma membrane
Basal bodies in jawed vertebrates appear to first attach to a ciliary vesicle. It is unclear how specific this is to jawed vertebrates or if other organisms also employ this sequence. Some species like Giardia intestinalis do not relocate their basal bodies to the plasma membrane, but have their axonemes extend through the cytosol to then protrude out of the cell to form flagella.
ciliary basal body-plasma membrane docking
The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces.
vesicle targeting, trans-Golgi to periciliary membrane compartment
The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.
Centriole assembly in which a centriole arises de novo, rather than by replication from an existing centriole. This process may occur via different mechanisms. Examples include the deuterosome pathway in multicilated epithelial animal cells and formation of centrioles during parthenogenesis in some insects.
A neuromuscular junction in which the target muscle cell is a myotube.
In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting the myotubes of skeletal muscle (AKA skeletal muscle fibers). Neuromuscular junctions targeting other muscle cell types exist in invertebrates such as the mononucleate somatic muscles of nematodes.
The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract.
A cellular process that results in the assembly of one or more centrioles.
Centriole assembly in which a centriole arises de novo by a process involving an electron-dense structure known as a deuterosome, rather than by duplication of an existing centriole, and occurring as part of multi-ciliated epithelial cell differentiation.
de novo centriole assembly via deuterosome
deuterosome-mediated centriole biogenesis
In most eukaryotic cells, 'centriole' (GO:0005814) and 'ciliary basal body' (GO:0036064) represent a common entity that cycles through its function in cell division, then ciliogenesis, then cell division again. However, these structures are modified extensively as they transition into each other, and may contain different proteins, specific to each component.
de novo centriole assembly involved in multi-ciliated epithelial cell differentiation
A spherical, electron dense, cytoplasmic structure that is involved in de novo assembly of centrioles.
Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism.
defence response incompatible interaction
defence response to pathogen, incompatible interaction
defense response, incompatible interaction
Any process in which a protein complex is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of protein complexes that move away.
Any process in which a protein complex is maintained in a specific location within the cytoplasm and is prevented from moving elsewhere.
maintenance of protein complex location in cytoplasm
The lipid bilayer that forms the outer-most layer of an organelle.
Examples include the outer membranes of double membrane bound organelles such as mitochondria as well as the bounding membranes of single-membrane bound organelles such as lysosomes.
A membrane that is a (regional) part of the plasma membrane.
Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass.
A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands).
A complex of collagen trimers such as a fibril or collagen network.
A supramolecular complex that consists of collagen triple helices associated to form a network.
The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis.
The directed movement of inorganic anions from outside of a cell, across the plasma membrane and into the cytosol.
inorganic anion import across plasma membrane
The directed movement of inorganic cations from outside of a cell, across the plasma membrane and into the cytosol.
inorganic cation import across plasma membrane
The process in which an inorganic ion is transported across a membrane.
The process in which an inorganic anion is transported across a membrane.
A process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
transmembrane inorganic cation transport
inorganic cation transmembrane transport
The directed movement of a carbohydrate from outside of a cell, across the plasma membrane and into the cytosol.
carbohydrate import across plasma membrane
Division of a stem cell during which it retains its identity and buds off a daughter cell with a new identity.
The self-renewing division of a germline stem cell, to produce a daughter stem cell and a daughter germ cell which will divide to form one or more gametes.
The directed movement of some substance from outside of a cell, across the plasma membrane and into the cytosol.
The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
Not to be used for manual annotation. Please choose a more specific cell development term or if not possible, bone or bone tissue development.
The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure.
The part of a synapse that is part of the presynaptic cell.
The part of a synapse that is part of the post-synaptic cell.
Any protein complex that is part of a membrane.
Any protein complex that is part of the plasma membrane.
The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
The portion of the cytoskeleton that lies within a dendritic spine. The actin component of this cytoskeleton is involved in spine head remodeling in response to postsynaptic signaling.
The directed movement of a protein along a microtubule, mediated by motor proteins.
The increase in size or mass of an intramembranous bone that contributes to the shaping of the bone.
The increase in size or mass of a bone that contributes to the shaping of that bone.
The actin cytoskeleton that is part of a postsynapse.
The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis.
vesicle-mediated transport to the plasma membrane
A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared.
Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
The ion channels through which current flows during an action potential should be annotated to the process 'action potential'. Gene products involved in modulating the characteristics of an action potential via changing the expression levels or the activity of these channels (e.g. modulating their kinetics or voltage sensitivity) should be annotated to this regulation term.
Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
regulation of cardiac muscle cell action potential
Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
regulation of AV node cardiac muscle cell action potential
regulation of atrioventricular node cardiac muscle cell action potential
regulation of AV node cell action potential
Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a Purkinje myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
regulation of Purkinje myocyte action potential
Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an SA node cardiac myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
regulation of SA node cardiac muscle cell action potential
regulation of SAN cardiac muscle cell action potential
regulation of sinoatrial node cardiac muscle cell action potential
regulation of sinus node cardiac muscle cell action potential
regulation of SA node cell action potential
Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a neuron. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
Cell-cell signaling from pre to post-synapse, across the synaptic cleft.
Cell-cell signaling from post to pre-synapse, across the synaptic cleft.
Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand.
retrograde trans-synaptic signaling by lipid
Signal transduction in which the initial step occurs in a postsynapse.
Signal transduction in which the initial step occurs in a presynapse.
The directed movement of organelles or molecules along microtubules in axons.
The directed movement of organelles or molecules along microtubules in a dendrite from the postsynapse towards the cell body.
The directed movement of organelles or molecules along microtubules in dendrites.
The directed movement of organelles or molecules along microtubules from the cell body toward the postsynapse in dendrites.
The actin cytoskeleton that is part of a dendritic spine.
The directed movement of a ribonucleoprotein complex along microtubules in nerve cell dendrites.
dendritic transport of ribonucleoprotein complex
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton.
postsynaptic actin cytoskeleton organization
The postsynapse of a neuromuscular junction. In vertebrate muscles this includes the motor end-plate, consisting of postjunctional folds of the sarcolemma.
A synapse that uses acetylcholine as a neurotransmitter.
A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals.
Any vesicle-mediated transport that occurs in a synapse.
The lipid bilayer surrounding a neuronal dense core vesicle.
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuronal dense core vesicle.
neuronal dense core vesicle organization
The aggregation, arrangement and bonding together of a set of components to form a presynapse.
The aggregation, arrangement and bonding together of a set of components to form a postsynapse.
A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber.
Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a neuropeptide.
retrograde trans-synaptic signaling by neuropeptide
Modulation of synaptic transmission by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide.
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission
The movement of a cellular component as a result of microtubule polymerization.
microtubule polymerization based movement
A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
The transport of a protein driven by polymerization of a microtubule to which it is attached.
microtubule polymerization based protein transport
A microtubule-based process that results in the transport of proteins.
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton.
presynaptic actin cytoskeleton organization
The actin cytoskeleton that is part of a presynapse.
Cell-cell signaling in which the ligand is carried between cells by an exosome.
Transynaptic signaling in which the ligand is carried across the synapse by an exosome.
exosome mediated transynaptic signalling
Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission.
postsynaptic modulation of chemical synaptic transmission
Any process, acting in the presynapse that results in modulation of chemical synaptic transmission.
presynaptic modulation of chemical synaptic transmission
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse.
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse.
Any process that modulates the physical form of a presynapse.
regulation of presynapse organization and biogenesis
Any process that modulates the physical form of a postsynapse.
regulation of postsynapse organization and biogenesis
Any process that modulates the frequency, rate or extent of trans-synaptic signaling.
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures and their associated proteins in the presynaptic cytoskeleton.
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton.
Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space.
The lipid bilayer surrounding an exocytic vesicle.
A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space.
A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure.
A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits.
The transport of organelles or other particles from one location in the cell to another along actin filaments.
The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins.
cytoskeletal fiber-based vesicle localization
The directed movement of dense core granules along cytoskeletal fibers, such as microtubules or actin filaments.
dense core vesicle cytoskeletal trafficking
dense core granule cytoskeletal transport
Any (proper) part of the cytosol of a single cell of sufficient size to still be considered cytosol.
The region of the cytosol consisting of all cytosol that is part of the presynapse.
The region of the cytosol consisting of all cytosol that is part of the postsynapse.
The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission.
presynaptic process involved in chemical synaptic transmission
Cell-cell signaling to, from or within a synapse.
Cell-cell signaling in either direction across the synaptic cleft.
Cell-cell signaling to or from a synapse, mediated by a peptide.
Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft.
trans-synaptic signaling by neuropeptide
Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid.
Any process that modulates synaptic transmission by regulating translation occurring at the synapse.
regulation of translation at synapse, modulating synaptic transmission
Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse.
trans-synaptic signaling, modulating synaptic transmission
Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse.
trans-synaptic signaling by neuropeptide, modulating synaptic transmission
Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse.
trans-synaptic signaling by lipid, modulating synaptic transmission
Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm.
The portion of the cytoskeleton contained within the presynapse.
The portion of the cytoskeleton contained within the postsynapse.
Any process that modulates synaptic transmission by regulating translation occurring at the presynapse.
regulation of translation at presynapse, modulating synaptic transmission
Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse.
regulation of translation at postsynapse, modulating synaptic transmission
The directed movement of inorganic ions from outside of a cell, across the plasma membrane and into the cytosol.
inorganic ion import across plasma membrane
A process in which a protein is transported to or maintained in a location within an axon.
A process in which protein is transported from one region of the plasma membrane to another.
protein transport within plasma membrane
The directed movement of proteins along microtubules in neuron projections.
The directed movement of proteins along microtubules from the cell body toward the cell periphery in nerve cell axons.
The directed movement of proteins along microtubules from the cell periphery toward the cell body in nerve cell axons.
The complete extent of cell cortex that underlies some some region of the plasma membrane.
Any action potential process that regulates skeletal muscle contraction.
regulation of skeletal muscle contraction by action potential
The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population.
A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the nuclear inner or outer membrane during mitosis.
nuclear membrane organization involved in mitotic nuclear division
This process only occurs in organisms which undergo 'closed mitosis' without nuclear breakdown.
The process in which a nuclear membrane is synthesized, aggregates, and bonds together.
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite.
Any process that modulates the frequency, rate or extent of vesicle fusion with Golgi apparatus.
regulation of vesicle fusion with Golgi apparatus
Any process that stops, prevents or reduces the frequency, rate or extent of vesicle fustion with Golgi apparatus.
negative regulation of vesicle fusion with Golgi apparatus
Any process that activates or increases the frequency, rate or extent of vesicle fusion with Golgi apparatus.
positive regulation of vesicle fusion with Golgi apparatus
Any process that modulates the frequency, rate or extent of the assembly, disassembly or arrangement of constituent parts of the basement membrane.
regulation of basement membrane organization
Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin.
regulation of actomyosin structure organization
The multiplication or reproduction of cardiac muscle myoblasts, resulting in the expansion of a cardiac muscle myoblast cell population. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life.
Any process that modulates the frequency, rate or extent of cardiac muscle myoblast proliferation.
regulation of cardiac muscle myoblast proliferation
Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle myoblast proliferation.
negative regulation of cardiac muscle myoblast proliferation
Any process that activates or increases the frequency, rate or extent of cardiac muscle myoblast proliferation.
positive regulation of cardiac muscle myoblast proliferation
Any process that modulates the frequency, rate or extent of actin filament organization.
regulation of actin filament organization
Any process that modulates the frequency, rate or extent of blood vessel endothelial cell differentiation.
regulation of blood vessel endothelial cell differentiation
Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell differentiation.
positive regulation of blood vessel endothelial cell differentiation
Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel endothelial cell differentiation.
negative regulation of blood vessel endothelial cell differentiation
A cellular transport process in which transported substances are moved in extracellular vesicles between cells; transported substances are enclosed in the vesicle lumen or located in the extracellular vesicle membrane.
vesicle-mediated intercellular transport
Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis.
positive regulation of animal organ morphogenesis
Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis.
negative regulation of animal organ morphogenesis
Any process that modulates the frequency, rate or extent of compound eye photoreceptor cell differentiation.
regulation of compound eye photoreceptor cell differentiation
Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor cell differentiation.
positive regulation of compound eye photoreceptor cell differentiation
Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor cell differentiation.
negative regulation of compound eye photoreceptor cell differentiation
The orderly movement of a myotube cell from one site to another, often during the development of a multicellular organism. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate, and fuse.
Any process that modulates the frequency, rate or extent of myotube cell migration.
Any process that activates, maintains or increases the frequency, rate or extent of myotube cell migration.
positive regulation of myotube cell migration
Any process that stops, prevents, or reduces the frequency, rate or extent of myotube cell migration.
negative regulation of myotube cell migration
A part of a cellular organism consisting of a material entity with granularity above the level of a protein complex but below that of an anatomical system. Note that cellular organisms exclude viruses.
A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon.
Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon.
plasma membrane bounded cell projection assembly
Any process that modulates the rate, frequency, or extent of plasma membrane bounded cell projection assembly.
regulation of plasma membrane bounded cell projection assembly
Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane bounded cell projection assembly.
negative regulation of plasma membrane bounded cell projection assembly
Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly.
positive regulation of plasma membrane bounded cell projection assembly
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections.
regulation of plasma membrane bounded cell projection organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon.
plasma membrane bounded cell projection organization
The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized.
plasma membrane bounded cell projection morphogenesis
All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection.
The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.
Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to chromatin.
negative regulation of protein localisation to chromatin
negative regulation of protein localization to chromatin
Any process that activates or increases the frequency, rate or extent of protein localization to chromatin.
positive regulation of protein localisation to chromatin
positive regulation of protein localization to chromatin
Any process that modulates the frequency, rate or extent of blastocyst development.
The process in which the larynx is generated and organized. The larynx is a continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration.
The biological process whose specific outcome is the progression of a larynx from an initial condition to its mature state. This process begins with the formation of the larynx and ends with the mature structure. A larynx is a continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration.
A process in which a protein is transported to, or maintained in, a location within a motile cilium.
protein localization to nonmotile primary cilium
The flow of blood through the network of arteries and veins supplying the cerebrum, enabling the transport of nutrients to the tissues and the removal of waste products.
Any process that modulates the frequency, rate or extent of cerebral blood circulation.
regulation of cerebrum blood circulation
regulation of telencephalon blood circulation
regulation of cerebral blood circulation
Any process that activates or increases the frequency, rate or extent of cerebral blood circulation.
positive regulation of cerebrum blood circulation
positive regulation of telencephalon blood circulation
up regulation of cerebral blood circulation
up-regulation of cerebral blood circulation
upregulation of cerebral blood circulation
activation of cerebral blood circulation
positive regulation of cerebral blood circulation
Any process that stops, prevents or reduces the frequency, rate or extent of cerebral blood circulation.
down regulation of cerebral blood circulation
down-regulation of cerebral blood circulation
downregulation of cerebral blood circulation
negative regulation of cerebrum blood circulation
negative regulation of telencephalon blood circulation
inhibition of cerebral blood circulation
negative regulation of cerebral blood circulation
Any process that modulates the frequency, rate or extent of the deposition or modulates the distribution of coloring matter in an organism.
The developmental process pertaining to the initial formation of an endothelial tube.
The initial formation of a spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum.
One of the two nuclear divisions that occur as part of the meiotic cell cycle.
A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.
The cellular processes that contribute to exocytosis.
The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other.
organelle localization by membrane tethering
The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content.
The directed movement of some substance from inside of a cell, across the plasma membrane and into the extracellular region.
The directed movement of an ammonium ion from outside of a cell, across the plasma membrane and into the cytosol.
Translation that occurs at the presynapse.
Translation that occurs at the presynapse, and that modulates chemical synaptic transmission.
translation at presynapse, modulating chemical synaptic transmission
Translation that occurs at the postsynapse.
Any process that regulates translation occurring at the synapse.
Any process that regulates translation occurring at the presynapse.
Any process that regulates translation occurring at the postsynapse.
regulation of translation at postsynapse
A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium.
The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis.
The directed movement of a lipid from a cell, into the extracellular region.
The directed movement of a lipid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis.
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus.
The division of a vacuole within a cell to form two or more separate vacuoles.
The radial migration of a pyramidal neuron along radial glial cells.
radial glia-dependent neuronal migration
radial glia-guided pyramidal neuron migration
The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle.
non-membrane-bounded organelle formation
non-membrane-enclosed organelle assembly
non-membrane-enclosed organelle formation
The directed movement of substances from the cytosol into the Golgi apparatus of a cell.
The biosynthetic process resulting in the formation of a nucleic acid.
Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse.
The process whose specific outcome is the progression of the visual system over time, from its formation to the mature structure, including the eye, parts of the central nervous system (CNS) involved in processing of visual inputs, and connecting nerve pathways.
The immediate defensive reaction by neural vertebrate tissue to infection or injury caused by chemical or physical agents.
Any process that modulates the frequency, rate or extent of neuroinflammatory response.
regulation of neuroinflammatory response
Any process that activates or increases the frequency, rate or extent of neuroinflammatory response.
positive regulation of neuroinflammatory response
Any process that stops, prevents or reduces the frequency, rate or extent of neuroinflammatory response.
negative regulation of neuroinflammatory response
Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signaling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum.
Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signaling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine.
A process in which a protein is transported to, or maintained, in a location within a cell-cell junction.
protein localization to cell-cell junction
Any process that modulates the frequency, rate or extent of protein localization to cell-cell junction.
regulation of protein localization to cell-cell junction
Any process that activates or increases the frequency, rate or extent of protein localization to cell-cell junction.
positive regulation of protein localization to cell-cell junction
Any process that modulates the frequency, rate or extent of transepithelial transport.
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell-cell junction.
negative regulation of protein localisation to cell-cell junction
negative regulation of protein localization to cell-cell junction
The disaggregation of a cell junction into its constituent components.
The disaggregation of a cell-cell junction into its constituent components.
The process whose specific outcome is the progression of a somatic sensory system over time from its formation to the mature structure. Somatic sensory system is the sensory system for the sense of touch and pain.
The regulated release of catecholamine by a cell in which the catecholamine acts as a neurotransmitter.
catecholamine secretion, neurotransmission
The process of fusing together the edges of a craniofacial suture.
The process whose specific outcome is the progression of cordate pharynx over time, from its formation to the mature structure.
Any process that activates or increases the frequency, rate or extent of dendrite development.
positive regulation of dendrite development
Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response.
regulation of cytokine production involved in acute inflammatory response
regulation of cytokine production involved in inflammatory response
Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response.
down regulation of cytokine production involved in acute inflammatory response
negative regulation of cytokine production involved in acute inflammatory response
down regulation of cytokine production involved in inflammatory response
negative regulation of cytokine production involved in inflammatory response
Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response.
up regulation of cytokine production involved in acute inflammatory response
positive regulation of cytokine production involved in acute inflammatory response
up regulation of cytokine production involved in inflammatory response
positive regulation of cytokine production involved in inflammatory response
Any regulation of signal transduction that takes place in the extracellular region.
regulation of signaling pathway in extracellular region
regulation of signalling pathway in extracellular region
extracellular regulation of signal transduction
Any negative regulation of signal transduction that takes place in extracellular region.
down regulation of signal transduction in extracellular region
down-regulation of signal transduction in extracellular region
downregulation of signal transduction in extracellular region
negative regulation of signaling pathway in extracellular region
negative regulation of signalling pathway in extracellular region
extracellular inhibition of signaling pathway
inhibition of signal transduction in extracellular region
extracellular negative regulation of signal transduction
Any process that modulates the frequency, rate or extent of execution phase of apoptosis.
regulation of execution phase of apoptosis
Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis.
down regulation of execution phase of apoptosis
down-regulation of execution phase of apoptosis
downregulation of execution phase of apoptosis
inhibition of execution phase of apoptosis
negative regulation of execution phase of apoptosis
Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis.
up regulation of execution phase of apoptosis
up-regulation of execution phase of apoptosis
upregulation of execution phase of apoptosis
activation of execution phase of apoptosis
positive regulation of execution phase of apoptosis
Any process that modulates the frequency, rate or extent of hyaluronan biosynthetic process.
regulation of hyaluronan biosynthetic process
Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process.
down regulation of hyaluronan biosynthesis
down regulation of hyaluronan biosynthetic process
down-regulation of hyaluronan biosynthesis
down-regulation of hyaluronan biosynthetic process
downregulation of hyaluronan biosynthesis
downregulation of hyaluronan biosynthetic process
negative regulation of hyaluronan anabolism
negative regulation of hyaluronan biosynthesis
negative regulation of hyaluronan formation
negative regulation of hyaluronan synthesis
inhibition of hyaluronan biosynthetic process
negative regulation of hyaluronan biosynthetic process
Any process that activates or increases the frequency, rate or extent of hyaluronan biosynthetic process.
positive regulation of hyaluronan anabolism
positive regulation of hyaluronan biosynthesis
positive regulation of hyaluronan formation
positive regulation of hyaluronan synthesis
up regulation of hyaluronan biosynthesis
up regulation of hyaluronan biosynthetic process
up-regulation of hyaluronan biosynthesis
up-regulation of hyaluronan biosynthetic process
upregulation of hyaluronan biosynthetic process
activation of hyaluronan biosynthetic process
positive regulation of hyaluronan biosynthetic process
Any process that modulates the frequency, rate or extent of oligodendrocyte apoptotic process.
regulation of oligodendrocyte apoptotic process
Any process that stops, prevents or reduces the frequency, rate or extent of oligodendrocyte apoptotic process.
down regulation of oligodendrocyte apoptotic process
down-regulation of oligodendrocyte apoptotic process
downregulation of oligodendrocyte apoptotic process
down regulation of oligodendrocyte apoptosis
down-regulation of oligodendrocyte apoptosis
downregulation of oligodendrocyte apoptosis
inhibition of oligodendrocyte apoptotic process
negative regulation of oligodendrocyte apoptosis
negative regulation of oligodendrocyte apoptotic process
Any process that activates or increases the frequency, rate or extent of oligodendrocyte apoptotic process.
up regulation of oligodendrocyte apoptotic process
up-regulation of oligodendrocyte apoptotic process
upregulation of oligodendrocyte apoptotic process
activation of oligodendrocyte apoptotic process
positive regulation of oligodendrocyte apoptosis
up regulation of oligodendrocyte apoptosis
up-regulation of oligodendrocyte apoptosis
upregulation of oligodendrocyte apoptosis
positive regulation of oligodendrocyte apoptotic process
Any process that modulates the frequency, rate or extent of Schwann cell migration.
Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell migration.
down regulation of Schwann cell migration
down-regulation of Schwann cell migration
downregulation of Schwann cell migration
negative regulation of Schwann cell migration
Any process that activates or increases the frequency, rate or extent of Schwann cell migration.
positive regulation of Schwann cell migration
Any process that modulates the frequency, rate or extent of protein localization to nucleus.
regulation of protein localisation to nucleus
regulation of protein localization in cell nucleus
regulation of protein localization in nucleus
regulation of protein localization to nucleus
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus.
down regulation of protein localisation to nucleus
down regulation of protein localization in cell nucleus
down regulation of protein localization in nucleus
down regulation of protein localization to nucleus
down-regulation of protein localisation to nucleus
down-regulation of protein localization in cell nucleus
down-regulation of protein localization in nucleus
down-regulation of protein localization to nucleus
downregulation of protein localisation to nucleus
downregulation of protein localization in cell nucleus
downregulation of protein localization in nucleus
downregulation of protein localization to nucleus
negative regulation of protein localisation to nucleus
negative regulation of protein localization in cell nucleus
negative regulation of protein localization in nucleus
inhibition of protein localisation to nucleus
inhibition of protein localization in cell nucleus
inhibition of protein localization in nucleus
inhibition of protein localization to nucleus
negative regulation of protein localization to nucleus
Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.
activation of protein localization in nucleus
positive regulation of protein localisation to nucleus
positive regulation of protein localization in cell nucleus
positive regulation of protein localization in nucleus
up regulation of protein localisation to nucleus
up regulation of protein localization in cell nucleus
up regulation of protein localization in nucleus
up regulation of protein localization to nucleus
up-regulation of protein localisation to nucleus
up-regulation of protein localization in cell nucleus
up-regulation of protein localization in nucleus
up-regulation of protein localization to nucleus
upregulation of protein localisation to nucleus
upregulation of protein localization in cell nucleus
upregulation of protein localization in nucleus
upregulation of protein localization to nucleus
activation of protein localisation to nucleus
activation of protein localization in cell nucleus
activation of protein localization to nucleus
positive regulation of protein localization to nucleus
Any process that modulates the frequency, rate or extent of oocyte maturation.
Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation.
negative regulation of oocyte maturation
Any process that activates or increases the frequency, rate or extent of oocyte maturation.
positive regulation of oocyte maturation
Any process that modulates the frequency, rate or extent of cytoplasmic translational elongation.
regulation of cytoplasmic translational elongation
Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational elongation.
down regulation of cytoplasmic translational elongation
down-regulation of cytoplasmic translational elongation
downregulation of cytoplasmic translational elongation
inhibition of cytoplasmic translational elongation
negative regulation of cytoplasmic translational elongation
Any process that activates or increases the frequency, rate or extent of cytoplasmic translational elongation.
up regulation of cytoplasmic translational elongation
up-regulation of cytoplasmic translational elongation
upregulation of cytoplasmic translational elongation
activation of cytoplasmic translational elongation
positive regulation of cytoplasmic translational elongation
Any process that stops, prevents or reduces the frequency, rate or extent of defense response to insect.
down regulation of defense response to insect
down regulation of physiological defense response to insect
down-regulation of defense response to insect
down-regulation of physiological defense response to insect
downregulation of defense response to insect
downregulation of physiological defense response to insect
negative regulation of physiological defense response to insect
inhibition of defense response to insect
inhibition of physiological defense response to insect
negative regulation of defense response to insect
Any process that activates or increases the frequency, rate or extent of defense response to insect.
positive regulation of physiological defense response to insect
up regulation of defense response to insect
up regulation of physiological defense response to insect
up-regulation of defense response to insect
up-regulation of physiological defense response to insect
upregulation of defense response to insect
upregulation of physiological defense response to insect
activation of defense response to insect
activation of physiological defense response to insect
positive regulation of defense response to insect
Any process that modulates the frequency, rate or extent of secondary metabolite biosynthetic process.
regulation of secondary metabolite biosynthesis
regulation of secondary metabolite biosynthetic process
Any process that stops, prevents or reduces the frequency, rate or extent of secondary metabolite biosynthetic process.
down regulation of secondary metabolite biosynthesis
down regulation of secondary metabolite biosynthetic process
down-regulation of secondary metabolite biosynthesis
down-regulation of secondary metabolite biosynthetic process
downregulation of secondary metabolite biosynthesis
downregulation of secondary metabolite biosynthetic process
inhibition of secondary metabolite biosynthesis
negative regulation of secondary metabolite biosynthesis
inhibition of secondary metabolite biosynthetic process
negative regulation of secondary metabolite biosynthetic process
Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process.
activation of secondary metabolite biosynthesis
positive regulation of secondary metabolite biosynthesis
up regulation of secondary metabolite biosynthesis
up regulation of secondary metabolite biosynthetic process
up-regulation of secondary metabolite biosynthesis
up-regulation of secondary metabolite biosynthetic process
upregulation of secondary metabolite biosynthesis
upregulation of secondary metabolite biosynthetic process
activation of secondary metabolite biosynthetic process
positive regulation of secondary metabolite biosynthetic process
The chemical reactions and pathways involving an acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid.
The chemical reactions and pathways resulting in the formation of an acetate esteran acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid.
The chemical reactions and pathways involving carbohydrate derivative.
carbohydrate derivative metabolic process
The chemical reactions and pathways resulting in the formation of carbohydrate derivative.
carbohydrate derivative biosynthetic process
Any gene expression that is involved in extracellular matrix organization. Gene expression includes both transcription to produce an RNA transcript, and the translation of that mRNA into protein. Protein maturation is included in gene expression when required to form an active form of a product from an inactive precursor form.
expression of extracellular matrix proteins
gene expression involved in extracellular matrix organization
The chemical reactions and pathways involving primary amino compound.
primary amino compound metabolic process
The chemical reactions and pathways resulting in the formation of primary amino compound.
primary amino compound biosynthetic process
Any process that modulates the frequency, rate or extent of trophoblast cell migration.
regulation of trophoblast cell migration
Any process that stops, prevents or reduces the frequency, rate or extent of trophoblast cell migration.
down regulation of trophoblast cell migration
down-regulation of trophoblast cell migration
downregulation of trophoblast cell migration
inhibition of trophoblast cell migration
negative regulation of trophoblast cell migration
Any process that activates or increases the frequency, rate or extent of trophoblast cell migration.
up regulation of trophoblast cell migration
up-regulation of trophoblast cell migration
upregulation of trophoblast cell migration
activation of trophoblast cell migration
positive regulation of trophoblast cell migration
Any neural crest cell migration that is involved in autonomic nervous system development.
neural crest cell migration involved in autonomic nervous system development
Any process that modulates the frequency, rate or extent of formation of translation initiation ternary complex.
regulation of translation initiation ternary complex assembly
regulation of formation of translation initiation ternary complex
Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation initiation ternary complex.
down regulation of formation of translation initiation ternary complex
down regulation of translation initiation ternary complex assembly
down-regulation of formation of translation initiation ternary complex
down-regulation of translation initiation ternary complex assembly
downregulation of formation of translation initiation ternary complex
downregulation of translation initiation ternary complex assembly
inhibition of translation initiation ternary complex assembly
negative regulation of translation initiation ternary complex assembly
inhibition of formation of translation initiation ternary complex
negative regulation of formation of translation initiation ternary complex
Any process that activates or increases the frequency, rate or extent of formation of translation initiation ternary complex.
activation of translation initiation ternary complex assembly
positive regulation of translation initiation ternary complex assembly
up regulation of formation of translation initiation ternary complex
up regulation of translation initiation ternary complex assembly
up-regulation of formation of translation initiation ternary complex
up-regulation of translation initiation ternary complex assembly
upregulation of formation of translation initiation ternary complex
upregulation of translation initiation ternary complex assembly
activation of formation of translation initiation ternary complex
positive regulation of formation of translation initiation ternary complex
Any process that modulates the frequency, rate or extent of extracellular matrix assembly.
regulation of extracellular matrix assembly
Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix assembly.
down regulation of extracellular matrix assembly
down-regulation of extracellular matrix assembly
downregulation of extracellular matrix assembly
inhibition of extracellular matrix assembly
negative regulation of extracellular matrix assembly
Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly.
up regulation of extracellular matrix assembly
up-regulation of extracellular matrix assembly
upregulation of extracellular matrix assembly
activation of extracellular matrix assembly
positive regulation of extracellular matrix assembly
Any process that modulates the frequency, rate or extent of cardiac chamber formation.
Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber formation.
down regulation of cardiac chamber formation
down regulation of heart chamber formation
down-regulation of cardiac chamber formation
down-regulation of heart chamber formation
downregulation of cardiac chamber formation
downregulation of heart chamber formation
negative regulation of heart chamber formation
negative regulation of cardiac chamber formation
Any process that activates or increases the frequency, rate or extent of cardiac chamber formation.
positive regulation of heart chamber formation
up regulation of cardiac chamber formation
up regulation of heart chamber formation
up-regulation of cardiac chamber formation
up-regulation of heart chamber formation
upregulation of cardiac chamber formation
positive regulation of cardiac chamber formation
Any process that modulates the frequency, rate or extent of cardiac chamber morphogenesis.
regulation of heart chamber morphogenesis
regulation of cardiac chamber morphogenesis
Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber morphogenesis.
down regulation of cardiac chamber morphogenesis
down regulation of heart chamber morphogenesis
down-regulation of cardiac chamber morphogenesis
down-regulation of heart chamber morphogenesis
downregulation of cardiac chamber morphogenesis
downregulation of heart chamber morphogenesis
negative regulation of heart chamber morphogenesis
inhibition of cardiac chamber morphogenesis
inhibition of heart chamber morphogenesis
negative regulation of cardiac chamber morphogenesis
Any process that activates or increases the frequency, rate or extent of cardiac chamber morphogenesis.
positive regulation of heart chamber morphogenesis
up regulation of cardiac chamber morphogenesis
up regulation of heart chamber morphogenesis
up-regulation of cardiac chamber morphogenesis
up-regulation of heart chamber morphogenesis
upregulation of cardiac chamber morphogenesis
upregulation of heart chamber morphogenesis
activation of cardiac chamber morphogenesis
activation of heart chamber morphogenesis
positive regulation of cardiac chamber morphogenesis
Any process that modulates the frequency, rate or extent of lung ciliated cell differentiation.
regulation of lung ciliated cell differentiation
Any process that stops, prevents or reduces the frequency, rate or extent of lung ciliated cell differentiation.
down regulation of lung ciliated cell differentiation
down-regulation of lung ciliated cell differentiation
downregulation of lung ciliated cell differentiation
inhibition of lung ciliated cell differentiation
negative regulation of lung ciliated cell differentiation
Any process that activates or increases the frequency, rate or extent of lung ciliated cell differentiation.
up regulation of lung ciliated cell differentiation
up-regulation of lung ciliated cell differentiation
upregulation of lung ciliated cell differentiation
activation of lung ciliated cell differentiation
positive regulation of lung ciliated cell differentiation
The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Any process that modulates the frequency, rate or extent of vasculature development.
regulation of vascular system development
Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development.
down regulation of vasculature development
down-regulation of vasculature development
downregulation of vasculature development
down regulation of vascular system development
down-regulation of vascular system development
downregulation of vascular system development
inhibition of vascular system development
negative regulation of vascular system development
negative regulation of vasculature development
The directed movement of an acetate ester into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Any process that modulates the frequency, rate or extent of response to acetate.
Any process that stops, prevents or reduces the frequency, rate or extent of response to acetate.
negative regulation of response to acetate
Any process that activates or increases the frequency, rate or extent of response to acetate.
positive regulation of response to acetate
Any process that modulates the frequency, rate or extent of endothelial tube morphogenesis.
regulation of endothelial tube morphogenesis
Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation.
regulation of haematopoietic progenitor cell differentiation
regulation of haemopoietic progenitor cell differentiation
regulation of hemopoietic progenitor cell differentiation
regulation of hematopoietic progenitor cell differentiation
Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation.
down regulation of haematopoietic progenitor cell differentiation
down regulation of haemopoietic progenitor cell differentiation
down regulation of hemopoietic progenitor cell differentiation
down-regulation of haematopoietic progenitor cell differentiation
down-regulation of haemopoietic progenitor cell differentiation
down-regulation of hemopoietic progenitor cell differentiation
downregulation of haematopoietic progenitor cell differentiation
downregulation of haemopoietic progenitor cell differentiation
downregulation of hemopoietic progenitor cell differentiation
inhibition of haematopoietic progenitor cell differentiation
inhibition of haemopoietic progenitor cell differentiation
negative regulation of haematopoietic progenitor cell differentiation
negative regulation of haemopoietic progenitor cell differentiation
negative regulation of hemopoietic progenitor cell differentiation
inhibition of hemopoietic progenitor cell differentiation
down regulation of hematopoietic progenitor cell differentiation
down-regulation of hematopoietic progenitor cell differentiation
downregulation of hematopoietic progenitor cell differentiation
inhibition of hematopoietic progenitor cell differentiation
negative regulation of hematopoietic progenitor cell differentiation
Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation.
activation of haematopoietic progenitor cell differentiation
activation of haemopoietic progenitor cell differentiation
positive regulation of haematopoietic progenitor cell differentiation
positive regulation of haemopoietic progenitor cell differentiation
positive regulation of hemopoietic progenitor cell differentiation
up regulation of haematopoietic progenitor cell differentiation
up regulation of haemopoietic progenitor cell differentiation
up regulation of hemopoietic progenitor cell differentiation
up-regulation of haematopoietic progenitor cell differentiation
up-regulation of haemopoietic progenitor cell differentiation
up-regulation of hemopoietic progenitor cell differentiation
upregulation of haematopoietic progenitor cell differentiation
upregulation of haemopoietic progenitor cell differentiation
upregulation of hemopoietic progenitor cell differentiation
activation of hemopoietic progenitor cell differentiation
activation of hematopoietic progenitor cell differentiation
up regulation of hematopoietic progenitor cell differentiation
up-regulation of hematopoietic progenitor cell differentiation
upregulation of hematopoietic progenitor cell differentiation
positive regulation of hematopoietic progenitor cell differentiation
Any process that modulates the frequency, rate or extent of endothelial cell development.
regulation of endothelial cell development
Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell development.
down regulation of endothelial cell development
down-regulation of endothelial cell development
downregulation of endothelial cell development
inhibition of endothelial cell development
negative regulation of endothelial cell development
Any process that activates or increases the frequency, rate or extent of endothelial cell development.
up regulation of endothelial cell development
up-regulation of endothelial cell development
upregulation of endothelial cell development
activation of endothelial cell development
positive regulation of endothelial cell development
Any microtubule in a dendrite, a neuron projection.
An arrangement of closely apposed microtubules running parallel to each other in the axon hillock and initial segment.
The chemical reactions and pathways involving an alpha-amino acid.
The chemical reactions and pathways resulting in the formation of an alpha-amino acid.
Any process that modulates the frequency, rate or extent of vesicle transport along microtubule.
regulation of microtubule-based vesicle localization
regulation of vesicle transport along microtubule
Any process that stops, prevents or reduces the frequency, rate or extent of vesicle transport along microtubule.
down regulation of microtubule-based vesicle localization
down regulation of vesicle transport along microtubule
down-regulation of microtubule-based vesicle localization
down-regulation of vesicle transport along microtubule
downregulation of microtubule-based vesicle localization
downregulation of vesicle transport along microtubule
inhibition of microtubule-based vesicle localization
negative regulation of microtubule-based vesicle localization
inhibition of vesicle transport along microtubule
negative regulation of vesicle transport along microtubule
Any process that activates or increases the frequency, rate or extent of vesicle transport along microtubule.
activation of microtubule-based vesicle localization
positive regulation of microtubule-based vesicle localization
up regulation of microtubule-based vesicle localization
up regulation of vesicle transport along microtubule
up-regulation of microtubule-based vesicle localization
up-regulation of vesicle transport along microtubule
upregulation of microtubule-based vesicle localization
upregulation of vesicle transport along microtubule
activation of vesicle transport along microtubule
positive regulation of vesicle transport along microtubule
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus.
Any process that modulates the frequency, rate or extent of compound eye retinal cell apoptotic process.
regulation of compound eye retinal cell apoptotic process
Any process that stops, prevents or reduces the frequency, rate or extent of compound eye retinal cell apoptotic process.
down regulation of compound eye retinal cell apoptotic process
down-regulation of compound eye retinal cell apoptotic process
downregulation of compound eye retinal cell apoptotic process
inhibition of compound eye retinal cell apoptotic process
negative regulation of compound eye retinal cell apoptotic process
Any process that activates or increases the frequency, rate or extent of compound eye retinal cell apoptotic process.
up regulation of compound eye retinal cell apoptotic process
up-regulation of compound eye retinal cell apoptotic process
upregulation of compound eye retinal cell apoptotic process
activation of compound eye retinal cell apoptotic process
induction of compound eye retinal cell programmed cell death
positive regulation of compound eye retinal cell apoptotic process
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus.
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus.
The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of bone as it progresses from its formation to the mature state.
mesenchymal cell differentiation involved in bone development
Any process that modulates the frequency, rate or extent of muscle tissue development.
Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development.
down regulation of muscle tissue development
down-regulation of muscle tissue development
downregulation of muscle tissue development
negative regulation of muscle tissue development
Any process that activates or increases the frequency, rate or extent of muscle tissue development.
up regulation of muscle tissue development
up-regulation of muscle tissue development
upregulation of muscle tissue development
positive regulation of muscle tissue development
Any process that modulates the frequency, rate or extent of protein depolymerization.
regulation of protein polymer catabolic process
regulation of protein polymer catabolism
regulation of protein polymer degradation
Any process that stops, prevents or reduces the frequency, rate or extent of protein depolymerization.
down regulation of protein depolymerization
down regulation of protein polymer breakdown
down regulation of protein polymer catabolic process
down regulation of protein polymer catabolism
down regulation of protein polymer degradation
down-regulation of protein depolymerization
down-regulation of protein polymer breakdown
down-regulation of protein polymer catabolic process
down-regulation of protein polymer catabolism
down-regulation of protein polymer degradation
downregulation of protein depolymerization
downregulation of protein polymer breakdown
downregulation of protein polymer catabolic process
downregulation of protein polymer catabolism
downregulation of protein polymer degradation
inhibition of protein polymer catabolic process
inhibition of protein polymer catabolism
inhibition of protein polymer degradation
negative regulation of protein polymer breakdown
negative regulation of protein polymer catabolic process
negative regulation of protein polymer catabolism
negative regulation of protein polymer degradation
negative regulation of protein depolymerization
Any process that activates or increases the frequency, rate or extent of protein depolymerization.
activation of protein polymer catabolic process
activation of protein polymer catabolism
activation of protein polymer degradation
positive regulation of protein polymer breakdown
positive regulation of protein polymer catabolic process
positive regulation of protein polymer catabolism
positive regulation of protein polymer degradation
up regulation of protein depolymerization
up regulation of protein polymer breakdown
up regulation of protein polymer catabolic process
up regulation of protein polymer catabolism
up regulation of protein polymer degradation
up-regulation of protein depolymerization
up-regulation of protein polymer breakdown
up-regulation of protein polymer catabolic process
up-regulation of protein polymer catabolism
up-regulation of protein polymer degradation
upregulation of protein depolymerization
upregulation of protein polymer breakdown
upregulation of protein polymer catabolic process
upregulation of protein polymer catabolism
upregulation of protein polymer degradation
positive regulation of protein depolymerization
Any process that modulates the frequency, rate or extent of cell junction assembly.
Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly.
down regulation of cell junction assembly
down-regulation of cell junction assembly
downregulation of cell junction assembly
negative regulation of cell junction assembly
Any process that activates or increases the frequency, rate or extent of cell junction assembly.
positive regulation of cell junction assembly
The directed movement a dense core granule within a cell.
Any process that modulates the frequency, rate or extent of anterograde dense core granule transport.
regulation of anterograde dense core granule transport
Any process that stops, prevents or reduces the frequency, rate or extent of anterograde dense core granule transport.
down regulation of anterograde dense core granule transport
down-regulation of anterograde dense core granule transport
downregulation of anterograde dense core granule transport
inhibition of anterograde dense core granule transport
negative regulation of anterograde dense core granule transport
Any process that activates or increases the frequency, rate or extent of anterograde dense core granule transport.
up regulation of anterograde dense core granule transport
up-regulation of anterograde dense core granule transport
upregulation of anterograde dense core granule transport
activation of anterograde dense core granule transport
positive regulation of anterograde dense core granule transport
Any process that modulates the frequency, rate or extent of retrograde dense core granule transport.
regulation of retrograde dense core granule transport
Any process that stops, prevents or reduces the frequency, rate or extent of retrograde dense core granule transport.
down regulation of retrograde dense core granule transport
down-regulation of retrograde dense core granule transport
downregulation of retrograde dense core granule transport
inhibition of retrograde dense core granule transport
negative regulation of retrograde dense core granule transport
Any process that activates or increases the frequency, rate or extent of retrograde dense core granule transport.
up regulation of retrograde dense core granule transport
up-regulation of retrograde dense core granule transport
upregulation of retrograde dense core granule transport
activation of retrograde dense core granule transport
positive regulation of retrograde dense core granule transport
Any process that modulates the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis.
regulation of cell proliferation involved in outflow tract morphogenesis
Any process that activates or increases the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis.
up regulation of cell proliferation involved in outflow tract morphogenesis
up-regulation of cell proliferation involved in outflow tract morphogenesis
upregulation of cell proliferation involved in outflow tract morphogenesis
activation of cell proliferation involved in outflow tract morphogenesis
positive regulation of cell proliferation involved in outflow tract morphogenesis
Any process that modulates the frequency, rate or extent of cilium assembly.
Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly.
negative regulation of cilium biogenesis
Any process that modulates the frequency, rate or extent of cilium-dependent cell motility.
regulation of cilium-dependent cell motility
Any process that stops, prevents or reduces the frequency, rate or extent of cilium-dependent cell motility.
down regulation of ciliary cell motility
down-regulation of ciliary cell motility
negative regulation of cilium cell motility
negative regulation of ciliary cell motility
negative regulation of cilium-dependent cell motility
Any process that modulates the frequency, rate or extent of hematopoietic stem cell proliferation.
regulation of hemopoietic stem cell proliferation
regulation of hematopoietic stem cell proliferation
Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell proliferation.
down regulation of hematopoietic stem cell proliferation
down regulation of hemopoietic stem cell proliferation
down-regulation of hematopoietic stem cell proliferation
down-regulation of hemopoietic stem cell proliferation
downregulation of hematopoietic stem cell proliferation
downregulation of hemopoietic stem cell proliferation
negative regulation of hemopoietic stem cell proliferation
inhibition of hematopoietic stem cell proliferation
inhibition of hemopoietic stem cell proliferation
negative regulation of hematopoietic stem cell proliferation
Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell proliferation.
positive regulation of hemopoietic stem cell proliferation
up regulation of hematopoietic stem cell proliferation
up regulation of hemopoietic stem cell proliferation
up-regulation of hematopoietic stem cell proliferation
up-regulation of hemopoietic stem cell proliferation
upregulation of hematopoietic stem cell proliferation
upregulation of hemopoietic stem cell proliferation
activation of hematopoietic stem cell proliferation
activation of hemopoietic stem cell proliferation
positive regulation of hematopoietic stem cell proliferation
Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation.
regulation of haematopoietic stem cell differentiation
regulation of haemopoietic stem cell differentiation
regulation of hemopoietic stem cell differentiation
regulation of hematopoietic stem cell differentiation
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell differentiation.
down regulation of haematopoietic stem cell differentiation
down regulation of haemopoietic stem cell differentiation
down regulation of hematopoietic stem cell differentiation
down regulation of hemopoietic stem cell differentiation
down-regulation of haematopoietic stem cell differentiation
down-regulation of haemopoietic stem cell differentiation
down-regulation of hematopoietic stem cell differentiation
down-regulation of hemopoietic stem cell differentiation
downregulation of haematopoietic stem cell differentiation
downregulation of haemopoietic stem cell differentiation
downregulation of hematopoietic stem cell differentiation
downregulation of hemopoietic stem cell differentiation
negative regulation of haematopoietic stem cell differentiation
negative regulation of haemopoietic stem cell differentiation
negative regulation of hemopoietic stem cell differentiation
inhibition of haematopoietic stem cell differentiation
inhibition of haemopoietic stem cell differentiation
inhibition of hematopoietic stem cell differentiation
inhibition of hemopoietic stem cell differentiation
negative regulation of hematopoietic stem cell differentiation
Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell differentiation.
positive regulation of haematopoietic stem cell differentiation
positive regulation of haemopoietic stem cell differentiation
positive regulation of hemopoietic stem cell differentiation
up regulation of haematopoietic stem cell differentiation
up regulation of haemopoietic stem cell differentiation
up regulation of hematopoietic stem cell differentiation
up regulation of hemopoietic stem cell differentiation
up-regulation of haematopoietic stem cell differentiation
up-regulation of haemopoietic stem cell differentiation
up-regulation of hematopoietic stem cell differentiation
up-regulation of hemopoietic stem cell differentiation
upregulation of haematopoietic stem cell differentiation
upregulation of haemopoietic stem cell differentiation
upregulation of hematopoietic stem cell differentiation
upregulation of hemopoietic stem cell differentiation
activation of haematopoietic stem cell differentiation
activation of haemopoietic stem cell differentiation
activation of hematopoietic stem cell differentiation
activation of hemopoietic stem cell differentiation
positive regulation of hematopoietic stem cell differentiation
Any process that modulates the frequency, rate or extent of leukocyte differentiation.
regulation of immune cell differentiation
Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation.
down regulation of immune cell differentiation
down regulation of leucocyte differentiation
down regulation of leukocyte differentiation
down-regulation of immune cell differentiation
down-regulation of leucocyte differentiation
down-regulation of leukocyte differentiation
downregulation of immune cell differentiation
downregulation of leucocyte differentiation
downregulation of leukocyte differentiation
negative regulation of immune cell differentiation
negative regulation of leucocyte differentiation
inhibition of immune cell differentiation
negative regulation of leukocyte differentiation
Any process that activates or increases the frequency, rate or extent of leukocyte differentiation.
positive regulation of immune cell differentiation
positive regulation of leucocyte differentiation
up regulation of immune cell differentiation
up regulation of leucocyte differentiation
up regulation of leukocyte differentiation
up-regulation of immune cell differentiation
up-regulation of leucocyte differentiation
up-regulation of leukocyte differentiation
upregulation of immune cell differentiation
upregulation of leucocyte differentiation
upregulation of leukocyte differentiation
activation of immune cell differentiation
positive regulation of leukocyte differentiation
Any process that modulates the frequency, rate or extent of organelle assembly.
Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly.
negative regulation of organelle assembly
Any process that activates or increases the frequency, rate or extent of organelle assembly.
positive regulation of organelle assembly
Any apoptotic process in an erythrocyte.
Any process that modulates the frequency, rate or extent of erythrocyte apoptotic process.
regulation of red blood cell apoptotic process
regulation of erythrocyte apoptotic process
Any process that stops, prevents or reduces the frequency, rate or extent of erythrocyte apoptotic process.
down regulation of RBC apoptotic process
down regulation of erythrocyte apoptotic process
down regulation of red blood cell apoptotic process
down-regulation of RBC apoptotic process
down-regulation of erythrocyte apoptotic process
down-regulation of red blood cell apoptotic process
downregulation of erythrocyte apoptotic process
downregulation of red blood cell apoptotic process
negative regulation of RBC apoptotic process
negative regulation of red blood cell apoptotic process
down regulation of erythrocyte apoptosis
down regulation of red blood cell apoptosis
down-regulation of erythrocyte apoptosis
down-regulation of red blood cell apoptosis
downregulation of red blood cell apoptosis
inhibition of erythrocyte apoptotic process
inhibition of red blood cell apoptotic process
negative regulation of erythrocyte apoptosis
negative regulation of red blood cell apoptosis
negative regulation of erythrocyte apoptotic process
Any process that activates or increases the frequency, rate or extent of erythrocyte apoptotic process.
positive regulation of RBC apoptotic process
positive regulation of red blood cell apoptotic process
up regulation of erythrocyte apoptotic process
up regulation of red blood cell apoptotic process
up-regulation of erythrocyte apoptotic process
up-regulation of red blood cell apoptotic process
upregulation of erythrocyte apoptotic process
upregulation of red blood cell apoptotic process
activation of erythrocyte apoptotic process
activation of red blood cell apoptotic process
positive regulation of erythrocyte apoptosis
positive regulation of red blood cell apoptosis
up regulation of red blood cell apoptosis
up-regulation of red blood cell apoptosis
upregulation of red blood cell apoptosis
positive regulation of erythrocyte apoptotic process
Any process that modulates the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis.
regulation of apoptosis involved in outflow tract morphogenesis
regulation of apoptotic process involved in outflow tract morphogenesis
Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis.
down regulation of apoptotic process involved in outflow tract morphogenesis
down-regulation of apoptotic process involved in outflow tract morphogenesis
downregulation of apoptotic process involved in outflow tract morphogenesis
down regulation of apoptosis involved in outflow tract morphogenesis
down-regulation of apoptosis involved in outflow tract morphogenesis
downregulation of apoptosis involved in outflow tract morphogenesis
inhibition of apoptosis involved in outflow tract morphogenesis
inhibition of apoptotic process involved in outflow tract morphogenesis
negative regulation of apoptosis involved in outflow tract morphogenesis
negative regulation of apoptotic process involved in outflow tract morphogenesis
Any process that activates or increases the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis.
up regulation of apoptotic process involved in outflow tract morphogenesis
up-regulation of apoptotic process involved in outflow tract morphogenesis
upregulation of apoptotic process involved in outflow tract morphogenesis
activation of apoptosis involved in outflow tract morphogenesis
activation of apoptotic process involved in outflow tract morphogenesis
positive regulation of apoptosis involved in outflow tract morphogenesis
up regulation of apoptosis involved in outflow tract morphogenesis
up-regulation of apoptosis involved in outflow tract morphogenesis
upregulation of apoptosis involved in outflow tract morphogenesis
positive regulation of apoptotic process involved in outflow tract morphogenesis
Any apoptotic process that is involved in blood vessel morphogenesis.
apoptotic cell death involved in patterning of blood vessels
apoptotic programmed cell death involved in patterning of blood vessels
programmed cell death by apoptosis involved in patterning of blood vessels
apoptosis involved in patterning of blood vessels
apoptotic program involved in patterning of blood vessels
type I programmed cell death involved in patterning of blood vessels
signaling (initiator) caspase activity involved in patterning of blood vessels
apoptotic process involved in blood vessel morphogenesis
Any process that modulates the frequency, rate or extent of chromatin organization.
regulation of establishment or maintenance of chromatin architecture
regulation of chromatin assembly or disassembly
regulation of chromatin assembly/disassembly
Any process that modulates the frequency, rate or extent of apoptotic process involved in morphogenesis.
regulation of apoptosis involved in morphogenesis
regulation of apoptosis involved in development
regulation of apoptotic process involved in morphogenesis
Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in morphogenesis.
down regulation of apoptotic process involved in morphogenesis
down-regulation of apoptotic process involved in morphogenesis
downregulation of apoptotic process involved in morphogenesis
down regulation of apoptosis involved in morphogenesis
down-regulation of apoptosis involved in morphogenesis
downregulation of apoptosis involved in morphogenesis
inhibition of apoptosis involved in morphogenesis
inhibition of apoptotic process involved in morphogenesis
negative regulation of apoptosis involved in morphogenesis
down regulation of apoptosis involved in development
down regulation of morphogenetic apoptosis
down-regulation of apoptosis involved in development
down-regulation of morphogenetic apoptosis
downregulation of apoptosis involved in development
downregulation of morphogenetic apoptosis
inhibition of apoptosis involved in development
negative regulation of apoptosis involved in development
negative regulation of morphogenetic apoptosis
negative regulation of apoptotic process involved in morphogenesis
Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis.
up regulation of apoptotic process involved in morphogenesis
up-regulation of apoptotic process involved in morphogenesis
upregulation of apoptotic process involved in morphogenesis
activation of apoptosis involved in morphogenesis
activation of apoptotic process involved in morphogenesis
positive regulation of apoptosis involved in morphogenesis
up regulation of apoptosis involved in morphogenesis
up-regulation of apoptosis involved in morphogenesis
upregulation of apoptosis involved in morphogenesis
activation of apoptosis involved in development
positive regulation of apoptosis involved in development
positive regulation of morphogenetic apoptosis
up regulation of apoptosis involved in development
up regulation of morphogenetic apoptosis
up-regulation of apoptosis involved in development
up-regulation of morphogenetic apoptosis
upregulation of apoptosis involved in development
positive regulation of apoptotic process involved in morphogenesis
Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation.
down regulation of chromosome condensation
down regulation of eukaryotic chromosome condensation
down regulation of nuclear chromosome condensation
down-regulation of chromosome condensation
down-regulation of eukaryotic chromosome condensation
down-regulation of nuclear chromosome condensation
downregulation of chromosome condensation
downregulation of eukaryotic chromosome condensation
downregulation of nuclear chromosome condensation
negative regulation of eukaryotic chromosome condensation
negative regulation of nuclear chromosome condensation
inhibition of eukaryotic chromosome condensation
inhibition of nuclear chromosome condensation
negative regulation of chromosome condensation
The directed movement of sulfate across a membrane.
A process in which a protein is transported to, or maintained in, a location within a cell junction.
The directed movement of sulfate from outside of a cell, across the plasma membrane and into the cytosol.
A process in which a protein is transported to, or maintained in, a location within a cell leading edge.
protein localisation in cell leading edge
protein localisation to cell leading edge
protein localization in cell leading edge
protein localization to cell leading edge
Any process that modulates the frequency, rate or extent of protein localization to synapse.
regulation of protein localisation to synapse
regulation of protein localization to synapse
Any process that activates or increases the frequency, rate or extent of protein localization to synapse.
positive regulation of protein localisation to synapse
up regulation of protein localisation to synapse
up regulation of protein localization to synapse
up-regulation of protein localisation to synapse
up-regulation of protein localization to synapse
upregulation of protein localisation to synapse
upregulation of protein localization to synapse
activation of protein localisation to synapse
activation of protein localization to synapse
positive regulation of protein localization to synapse
Any process that modulates the frequency, rate or extent of organelle transport along microtubule.
regulation of microtubule-based organelle localization
regulation of organelle transport along microtubule
Any process that modulates the frequency, rate or extent of intracellular signal transduction.
regulation of intracellular signaling cascade
regulation of intracellular signaling chain
regulation of intracellular protein kinase cascade
regulation of intracellular signal transduction pathway
regulation of signal transmission via intracellular cascade
regulation of intracellular signaling pathway
regulation of signal transduction via intracellular signaling cascade
regulation of intracellular signal transduction
Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction.
down regulation of intracellular signal transduction
down regulation of intracellular signaling chain
down-regulation of intracellular signal transduction
down-regulation of intracellular signaling chain
downregulation of intracellular signal transduction
downregulation of intracellular signaling chain
negative regulation of intracellular protein kinase cascade
negative regulation of intracellular signaling cascade
negative regulation of intracellular signaling chain
down regulation of intracellular signal transduction pathway
down regulation of intracellular signaling cascade
down regulation of signal transmission via intracellular cascade
down-regulation of intracellular signal transduction pathway
downregulation of intracellular signal transduction pathway
downregulation of intracellular signaling cascade
downregulation of signal transmission via intracellular cascade
inhibition of intracellular signal transduction
inhibition of intracellular signal transduction pathway
inhibition of intracellular signaling cascade
inhibition of intracellular signaling chain
inhibition of signal transmission via intracellular cascade
negative regulation of intracellular signal transduction pathway
negative regulation of signal transmission via intracellular cascade
down regulation of intracellular signaling pathway
down regulation of signal transduction via intracellular signaling cascade
down-regulation of intracellular signaling cascade
down-regulation of intracellular signaling pathway
down-regulation of signal transduction via intracellular signaling cascade
down-regulation of signal transmission via intracellular cascade
downregulation of intracellular signaling pathway
downregulation of signal transduction via intracellular signaling cascade
inhibition of intracellular signaling pathway
inhibition of signal transduction via intracellular signaling cascade
negative regulation of intracellular signaling pathway
negative regulation of signal transduction via intracellular signaling cascade
negative regulation of intracellular signal transduction
Any process that activates or increases the frequency, rate or extent of intracellular signal transduction.
positive regulation of intracellular signaling chain
up regulation of intracellular signal transduction
up regulation of intracellular signaling chain
up-regulation of intracellular signal transduction
up-regulation of intracellular signaling chain
upregulation of intracellular signal transduction
upregulation of intracellular signaling chain
activation of intracellular signal transduction
activation of intracellular signal transduction pathway
activation of intracellular signaling cascade
activation of intracellular signaling chain
activation of signal transmission via intracellular cascade
positive regulation of intracellular protein kinase cascade
positive regulation of intracellular signal transduction pathway
positive regulation of signal transmission via intracellular cascade
up regulation of intracellular signal transduction pathway
up regulation of signal transmission via intracellular cascade
up-regulation of intracellular signal transduction pathway
up-regulation of signal transmission via intracellular cascade
upregulation of intracellular signal transduction pathway
upregulation of signal transmission via intracellular cascade
activation of intracellular signaling pathway
activation of signal transduction via intracellular signaling cascade
positive regulation of intracellular signaling cascade
positive regulation of intracellular signaling pathway
positive regulation of signal transduction via intracellular signaling cascade
up regulation of intracellular signaling cascade
up regulation of intracellular signaling pathway
up regulation of signal transduction via intracellular signaling cascade
up-regulation of intracellular signaling cascade
up-regulation of intracellular signaling pathway
up-regulation of signal transduction via intracellular signaling cascade
upregulation of intracellular signaling cascade
upregulation of intracellular signaling pathway
upregulation of signal transduction via intracellular signaling cascade
positive regulation of intracellular signal transduction
A process in which a protein is transported to, or maintained in, a location within a nucleolus.
Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process.
down regulation of RNA biosynthetic process
down-regulation of RNA biosynthetic process
downregulation of RNA biosynthetic process
negative regulation of RNA biosynthetic process
Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process.
up regulation of RNA biosynthetic process
up-regulation of RNA biosynthetic process
upregulation of RNA biosynthetic process
positive regulation of RNA biosynthetic process
Any process that modulates the frequency, rate or extent of neuroblast proliferation.
Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage.
regulation of chondrocyte differentiation involved in endochondral bone morphogenesis
Any apoptotic process that is involved in anatomical structure development.
apoptotic cell death involved in anatomical structure development
apoptotic cell death involved in development of an anatomical structure
apoptotic process involved in anatomical structure development
apoptotic process involved in development of an anatomical structure
apoptotic programmed cell death involved in anatomical structure development
apoptotic programmed cell death involved in development of an anatomical structure
programmed cell death by apoptosis involved in anatomical structure development
programmed cell death by apoptosis involved in development of an anatomical structure
activation of apoptosis involved in anatomical structure development
activation of apoptosis involved in development of an anatomical structure
apoptosis involved in anatomical structure development
apoptosis involved in development of an anatomical structure
apoptosis signaling involved in anatomical structure development
apoptosis signaling involved in development of an anatomical structure
apoptotic program involved in anatomical structure development
apoptotic program involved in development of an anatomical structure
type I programmed cell death involved in anatomical structure development
type I programmed cell death involved in development of an anatomical structure
apoptosis activator activity involved in anatomical structure development
apoptosis activator activity involved in development of an anatomical structure
commitment to apoptosis involved in anatomical structure development
commitment to apoptosis involved in development of an anatomical structure
induction of apoptosis by p53 involved in anatomical structure development
induction of apoptosis by p53 involved in development of an anatomical structure
induction of apoptosis involved in anatomical structure development
induction of apoptosis involved in development of an anatomical structure
signaling (initiator) caspase activity involved in anatomical structure development
signaling (initiator) caspase activity involved in development of an anatomical structure
apoptotic process involved in development
Any process that activates or increases the frequency, rate or extent of chondrocyte development.
up regulation of chondrocyte development
up-regulation of chondrocyte development
positive regulation of chondrocyte development
Any process that modulates the frequency, rate or extent of skeletal muscle fiber differentiation.
regulation of skeletal muscle fiber differentiation
Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle fiber differentiation.
down regulation of skeletal muscle fiber differentiation
down-regulation of skeletal muscle fiber differentiation
downregulation of skeletal muscle fiber differentiation
inhibition of skeletal muscle fiber differentiation
negative regulation of skeletal muscle fiber differentiation
Any process that activates or increases the frequency, rate or extent of skeletal muscle fiber differentiation.
up regulation of skeletal muscle fiber differentiation
up-regulation of skeletal muscle fiber differentiation
upregulation of skeletal muscle fiber differentiation
activation of skeletal muscle fiber differentiation
positive regulation of skeletal muscle fiber differentiation
Any process that modulates the frequency, rate or extent of protein localization to microtubule.
regulation of protein localisation to microtubule
regulation of protein localization to microtubule
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to microtubule.
down regulation of protein localisation to microtubule
down regulation of protein localization to microtubule
down-regulation of protein localisation to microtubule
down-regulation of protein localization to microtubule
downregulation of protein localisation to microtubule
downregulation of protein localization to microtubule
negative regulation of protein localisation to microtubule
inhibition of protein localisation to microtubule
inhibition of protein localization to microtubule
negative regulation of protein localization to microtubule
Any process that modulates the frequency, rate or extent of nuclear migration along microtubule.
regulation of nuclear movement, microtubule-mediated
regulation of microtubule cytoskeleton-dependent nuclear positioning
regulation of microtubule cytoskeleton-dependent nucleus positioning
regulation of microtubule-dependent nuclear positioning
regulation of microtubule-dependent nucleus positioning
regulation of microtubule-mediated nuclear migration
regulation of nuclear migration, microtubule-mediated
regulation of transport of nucleus by microtubules
regulation of transport of nucleus, microtubule-mediated
regulation of nuclear migration along microtubule
Any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration along microtubule.
down regulation of microtubule cytoskeleton-dependent nuclear positioning
down regulation of microtubule cytoskeleton-dependent nucleus positioning
down regulation of microtubule-dependent nuclear positioning
down regulation of microtubule-dependent nucleus positioning
down regulation of microtubule-mediated nuclear migration
down regulation of nuclear migration along microtubule
down regulation of nuclear migration, microtubule-mediated
down regulation of transport of nucleus by microtubules
down regulation of transport of nucleus, microtubule-mediated
down-regulation of microtubule cytoskeleton-dependent nuclear positioning
down-regulation of microtubule cytoskeleton-dependent nucleus positioning
down-regulation of microtubule-dependent nuclear positioning
down-regulation of microtubule-dependent nucleus positioning
down-regulation of microtubule-mediated nuclear migration
down-regulation of nuclear migration along microtubule
down-regulation of nuclear migration, microtubule-mediated
down-regulation of transport of nucleus by microtubules
down-regulation of transport of nucleus, microtubule-mediated
downregulation of microtubule cytoskeleton-dependent nuclear positioning
downregulation of microtubule cytoskeleton-dependent nucleus positioning
downregulation of microtubule-dependent nuclear positioning
downregulation of microtubule-dependent nucleus positioning
downregulation of microtubule-mediated nuclear migration
downregulation of nuclear migration along microtubule
downregulation of nuclear migration, microtubule-mediated
downregulation of transport of nucleus by microtubules
downregulation of transport of nucleus, microtubule-mediated
negative regulation of microtubule cytoskeleton-dependent nuclear positioning
negative regulation of microtubule cytoskeleton-dependent nucleus positioning
negative regulation of microtubule-dependent nuclear positioning
negative regulation of microtubule-dependent nucleus positioning
negative regulation of microtubule-mediated nuclear migration
negative regulation of nuclear migration, microtubule-mediated
negative regulation of transport of nucleus by microtubules
negative regulation of transport of nucleus, microtubule-mediated
inhibition of microtubule cytoskeleton-dependent nuclear positioning
inhibition of microtubule cytoskeleton-dependent nucleus positioning
inhibition of microtubule-dependent nuclear positioning
inhibition of microtubule-dependent nucleus positioning
inhibition of microtubule-mediated nuclear migration
inhibition of nuclear migration along microtubule
inhibition of nuclear migration, microtubule-mediated
inhibition of transport of nucleus by microtubules
inhibition of transport of nucleus, microtubule-mediated
negative regulation of nuclear migration along microtubule
Any process that activates or increases the frequency, rate or extent of nuclear migration along microtubule.
positive regulation of microtubule cytoskeleton-dependent nuclear positioning
positive regulation of microtubule cytoskeleton-dependent nucleus positioning
positive regulation of microtubule-dependent nuclear positioning
positive regulation of microtubule-dependent nucleus positioning
positive regulation of microtubule-mediated nuclear migration
positive regulation of nuclear migration, microtubule-mediated
positive regulation of transport of nucleus by microtubules
positive regulation of transport of nucleus, microtubule-mediated
up regulation of microtubule cytoskeleton-dependent nuclear positioning
up regulation of microtubule cytoskeleton-dependent nucleus positioning
up regulation of microtubule-dependent nuclear positioning
up regulation of microtubule-dependent nucleus positioning
up regulation of microtubule-mediated nuclear migration
up regulation of nuclear migration along microtubule
up regulation of nuclear migration, microtubule-mediated
up regulation of transport of nucleus by microtubules
up regulation of transport of nucleus, microtubule-mediated
up-regulation of microtubule cytoskeleton-dependent nuclear positioning
up-regulation of microtubule cytoskeleton-dependent nucleus positioning
up-regulation of microtubule-dependent nuclear positioning
up-regulation of microtubule-dependent nucleus positioning
up-regulation of microtubule-mediated nuclear migration
up-regulation of nuclear migration along microtubule
up-regulation of nuclear migration, microtubule-mediated
up-regulation of transport of nucleus by microtubules
up-regulation of transport of nucleus, microtubule-mediated
upregulation of microtubule cytoskeleton-dependent nuclear positioning
upregulation of microtubule cytoskeleton-dependent nucleus positioning
upregulation of microtubule-dependent nuclear positioning
upregulation of microtubule-dependent nucleus positioning
upregulation of microtubule-mediated nuclear migration
upregulation of nuclear migration along microtubule
upregulation of nuclear migration, microtubule-mediated
upregulation of transport of nucleus by microtubules
upregulation of transport of nucleus, microtubule-mediated
activation of microtubule cytoskeleton-dependent nuclear positioning
activation of microtubule cytoskeleton-dependent nucleus positioning
activation of microtubule-dependent nuclear positioning
activation of microtubule-dependent nucleus positioning
activation of microtubule-mediated nuclear migration
activation of nuclear migration along microtubule
activation of nuclear migration, microtubule-mediated
activation of transport of nucleus by microtubules
activation of transport of nucleus, microtubule-mediated
positive regulation of nuclear migration along microtubule
Any microtubule cytoskeleton organization that is involved in mitosis.
microtubule cytoskeleton organisation involved in mitosis
microtubule dynamics involved in mitosis
microtubule cytoskeleton organization and biogenesis involved in mitosis
microtubule cytoskeleton organization involved in mitosis
Any process that modulates the frequency, rate or extent of embryonic camera-type eye development.
regulation of embryonic camera-type eye development
Any process that stops, prevents or reduces the frequency, rate or extent of embryonic camera-type eye development.
down regulation of embryonic camera-type eye development
down regulation of embryonic eye development
down-regulation of embryonic camera-type eye development
down-regulation of embryonic eye development
downregulation of embryonic camera-type eye development
downregulation of embryonic eye development
negative regulation of embryonic eye development
inhibition of embryonic camera-type eye development
negative regulation of embryonic camera-type eye development
Any process that activates or increases the frequency, rate or extent of embryonic camera-type eye development.
positive regulation of embryonic eye development
up regulation of embryonic camera-type eye development
up regulation of embryonic eye development
up-regulation of embryonic camera-type eye development
up-regulation of embryonic eye development
upregulation of embryonic camera-type eye development
upregulation of embryonic eye development
activation of embryonic camera-type eye development
positive regulation of embryonic camera-type eye development
Any process that modulates the frequency, rate or extent of retina development in camera-type eye.
regulation of retina development in camera-style eye
regulation of retina development in camera-type eye
Any process that stops, prevents or reduces the frequency, rate or extent of retina development in camera-type eye.
down regulation of retina development in camera-style eye
down regulation of retina development in camera-type eye
down-regulation of retina development in camera-style eye
down-regulation of retina development in camera-type eye
downregulation of retina development in camera-style eye
downregulation of retina development in camera-type eye
negative regulation of retina development in camera-style eye
inhibition of retina development in camera-style eye
inhibition of retina development in camera-type eye
negative regulation of retinal development
negative regulation of retina development in camera-type eye
Any process that activates or increases the frequency, rate or extent of retina development in camera-type eye.
positive regulation of retina development in camera-style eye
up regulation of retina development in camera-style eye
up regulation of retina development in camera-type eye
up-regulation of retina development in camera-style eye
up-regulation of retina development in camera-type eye
upregulation of retina development in camera-style eye
upregulation of retina development in camera-type eye
activation of retina development in camera-style eye
activation of retina development in camera-type eye
positive regulation of retinal development
positive regulation of retina development in camera-type eye
Any process that modulates the frequency, rate or extent of embryonic pattern specification.
regulation of embryonic pattern biosynthesis
regulation of embryonic pattern formation
regulation of embryonic pattern specification
Any process that stops, prevents or reduces the frequency, rate or extent of embryonic pattern specification.
down regulation of embryonic pattern specification
down-regulation of embryonic pattern specification
downregulation of embryonic pattern specification
inhibition of embryonic pattern specification
down regulation of ventral/lateral system
down-regulation of ventral/lateral system
downregulation of ventral/lateral system
negative regulation of ventral/lateral system
negative regulation of embryonic pattern specification
Any process that activates or increases the frequency, rate or extent of embryonic pattern specification.
up regulation of embryonic pattern specification
up-regulation of embryonic pattern specification
upregulation of embryonic pattern specification
activation of embryonic pattern specification
positive regulation of ventral/lateral system
positive regulation of embryonic pattern specification
Any process that modulates the frequency, rate or extent of supramolecular fiber organization.
HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro
regulation of supramolecular fiber organization
Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization.
negative regulation of fibril organisation
negative regulation of supramolecular fiber organization
Any process that activates or increases the frequency, rate or extent of supramolecular fiber organization.
positive regulation of fibril organisation
positive regulation of supramolecular fiber organization
Any process that activates or increases the frequency, rate or extent of neuroepithelial cell differentiation.
up regulation of neuroepithelial cell differentiation
up-regulation of neuroepithelial cell differentiation
upregulation of neuroepithelial cell differentiation
activation of neuroepithelial cell differentiation
positive regulation of neuroepithelial cell differentiation
The disaggregation of an organelle into its constituent components.
Any process that modulates the frequency, rate or extent of bone development.
Any process that stops, prevents or reduces the frequency, rate or extent of bone development.
Any process that activates or increases the frequency, rate or extent of bone development.
Any process that modulates the frequency, rate or extent of glycoprotein metabolic process.
human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein
regulation of glycoprotein metabolic process
Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process.
down regulation of glycoprotein metabolic process
down regulation of glycoprotein metabolism
down-regulation of glycoprotein metabolic process
down-regulation of glycoprotein metabolism
downregulation of glycoprotein metabolic process
downregulation of glycoprotein metabolism
negative regulation of glycoprotein metabolism
inhibition of glycoprotein metabolic process
negative regulation of glycoprotein metabolic process
Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process.
positive regulation of glycoprotein metabolism
up regulation of glycoprotein metabolic process
up regulation of glycoprotein metabolism
up-regulation of glycoprotein metabolic process
up-regulation of glycoprotein metabolism
upregulation of glycoprotein metabolic process
activation of glycoprotein metabolic process
positive regulation of glycoprotein metabolic process
Any neural crest cell migration that is involved in sympathetic nervous system development.
Sema3a (O08665, mouse) is involved in neural crest cell migration involved in sympathetic nervous system development
neural crest cell migration involved in sympathetic nervous system development
A process that is part of the meiotic cell cycle.
A process that is part of the mitotic cell cycle.
Any process that modulates the frequency, rate or extent of extracellular matrix organization.
regulation of extracellular matrix organisation
regulation of extracellular matrix organization and biogenesis
regulation of extracellular matrix organization
Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization.
down regulation of extracellular matrix organisation
down regulation of extracellular matrix organization
down-regulation of extracellular matrix organisation
down-regulation of extracellular matrix organization
downregulation of extracellular matrix organisation
downregulation of extracellular matrix organization
negative regulation of extracellular matrix organisation
inhibition of extracellular matrix organisation
inhibition of extracellular matrix organization
down regulation of extracellular matrix organization and biogenesis
down-regulation of extracellular matrix organization and biogenesis
downregulation of extracellular matrix organization and biogenesis
inhibition of extracellular matrix organization and biogenesis
negative regulation of extracellular matrix organization and biogenesis
negative regulation of extracellular matrix organization
Any process that activates or increases the frequency, rate or extent of extracellular matrix organization.
positive regulation of extracellular matrix organisation
up regulation of extracellular matrix organisation
up regulation of extracellular matrix organization
up-regulation of extracellular matrix organisation
up-regulation of extracellular matrix organization
upregulation of extracellular matrix organisation
upregulation of extracellular matrix organization
activation of extracellular matrix organisation
activation of extracellular matrix organization
activation of extracellular matrix organization and biogenesis
positive regulation of extracellular matrix organization and biogenesis
up regulation of extracellular matrix organization and biogenesis
up-regulation of extracellular matrix organization and biogenesis
upregulation of extracellular matrix organization and biogenesis
positive regulation of extracellular matrix organization
Any process that modulates the frequency, rate or extent of protein localization to plasma membrane.
regulation of protein localization in plasma membrane
regulation of establishment of protein localisation in plasma membrane
regulation of establishment of protein localization in plasma membrane
regulation of establishment of protein localization to plasma membrane
regulation of protein localisation in plasma membrane
regulation of protein targeting to plasma membrane
regulation of protein-plasma membrane targeting
regulation of protein localization to plasma membrane
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane.
down regulation of protein localisation in plasma membrane
down regulation of protein localization in plasma membrane
down regulation of protein localization to plasma membrane
down-regulation of protein localisation in plasma membrane
down-regulation of protein localization in plasma membrane
down-regulation of protein localization to plasma membrane
downregulation of protein localisation in plasma membrane
downregulation of protein localization in plasma membrane
downregulation of protein localization to plasma membrane
negative regulation of protein localization in plasma membrane
inhibition of protein localisation in plasma membrane
inhibition of protein localization in plasma membrane
inhibition of protein localization to plasma membrane
inhibition of protein targeting to plasma membrane
inhibition of protein-plasma membrane targeting
down regulation of protein targeting to plasma membrane
down regulation of protein-plasma membrane targeting
down-regulation of protein targeting to plasma membrane
down-regulation of protein-plasma membrane targeting
downregulation of protein targeting to plasma membrane
downregulation of protein-plasma membrane targeting
negative regulation of establishment of protein localisation in plasma membrane
negative regulation of establishment of protein localization in plasma membrane
negative regulation of establishment of protein localization to plasma membrane
negative regulation of protein localisation in plasma membrane
negative regulation of protein targeting to plasma membrane
negative regulation of protein-plasma membrane targeting
negative regulation of protein localization to plasma membrane
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
positive regulation of protein localisation in plasma membrane
positive regulation of protein localization in plasma membrane
up regulation of protein localisation in plasma membrane
up regulation of protein localization in plasma membrane
up regulation of protein localization to plasma membrane
up-regulation of protein localisation in plasma membrane
up-regulation of protein localization in plasma membrane
up-regulation of protein localization to plasma membrane
upregulation of protein localisation in plasma membrane
upregulation of protein localization in plasma membrane
upregulation of protein localization to plasma membrane
activation of protein localisation in plasma membrane
activation of protein localization in plasma membrane
activation of protein localization to plasma membrane
activation of protein targeting to plasma membrane
activation of protein-plasma membrane targeting
positive regulation of establishment of protein localisation in plasma membrane
positive regulation of establishment of protein localization to plasma membrane
positive regulation of protein targeting to plasma membrane
positive regulation of protein-plasma membrane targeting
up regulation of protein targeting to plasma membrane
up regulation of protein-plasma membrane targeting
up-regulation of protein targeting to plasma membrane
up-regulation of protein-plasma membrane targeting
upregulation of protein targeting to plasma membrane
upregulation of protein-plasma membrane targeting
positive regulation of protein localization to plasma membrane
Any process that modulates the frequency, rate or extent of actin filament-based movement.
regulation of actin filament-based movement
Any process that activates or increases the frequency, rate or extent of actin filament-based movement.
up regulation of actin filament-based movement
up-regulation of actin filament-based movement
upregulation of actin filament-based movement
activation of actin filament-based movement
positive regulation of actin filament-based movement
A process in which a protein is transported to, or maintained in, the location of an actin cytoskeleton.
protein localisation in actin cytoskeleton
protein localisation to actin cytoskeleton
protein localization in actin cytoskeleton
protein localization to actin cytoskeleton
The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell.
Any process that modulates the frequency, rate or extent of endodermal cell differentiation.
regulation of endoderm cell differentiation
regulation of endodermal cell differentiation
Any process that stops, prevents or reduces the frequency, rate or extent of endodermal cell differentiation.
down regulation of endoderm cell differentiation
down regulation of endodermal cell differentiation
down-regulation of endoderm cell differentiation
down-regulation of endodermal cell differentiation
downregulation of endoderm cell differentiation
downregulation of endodermal cell differentiation
negative regulation of endoderm cell differentiation
inhibition of endoderm cell differentiation
inhibition of endodermal cell differentiation
negative regulation of endodermal cell differentiation
Any process that activates or increases the frequency, rate or extent of endodermal cell differentiation.
positive regulation of endoderm cell differentiation
up regulation of endoderm cell differentiation
up regulation of endodermal cell differentiation
up-regulation of endoderm cell differentiation
up-regulation of endodermal cell differentiation
upregulation of endoderm cell differentiation
upregulation of endodermal cell differentiation
activation of endoderm cell differentiation
activation of endodermal cell differentiation
positive regulation of endodermal cell differentiation
The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell.
multi-ciliated epithelial cell differentiation
A process in which a protein is transported to, or maintained in, a location within a Golgi membrane.
Any process that modulates the frequency, rate or extent of vacuolar transport.
Any process that stops, prevents or reduces the frequency, rate or extent of vacuolar transport.
negative regulation of vacuolar transport
Any process that activates or increases the frequency, rate or extent of vacuolar transport.
positive regulation of vacuolar transport
Any process that modulates the frequency, rate or extent of nucleus organization.
regulation of nuclear organization and biogenesis
regulation of nucleus organization and biogenesis
Any process that modulates the frequency, rate or extent of Golgi organization.
regulation of Golgi organization and biogenesis
Any process that modulates the frequency, rate or extent of mitotic chromosome condensation.
regulation of mitotic chromosome condensation
Any process that activates or increases the frequency, rate or extent of mitotic chromosome condensation.
up regulation of mitotic chromosome condensation
up-regulation of mitotic chromosome condensation
upregulation of mitotic chromosome condensation
activation of mitotic chromosome condensation
positive regulation of mitotic chromosome condensation
Any process that modulates the frequency, rate or extent of cell maturation.
regulation of functional differentiation
Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation.
down regulation of functional differentiation
down-regulation of functional differentiation
downregulation of functional differentiation
inhibition of functional differentiation
negative regulation of functional differentiation
Any process that activates or increases the frequency, rate or extent of cell maturation.
activation of functional differentiation
positive regulation of functional differentiation
up regulation of functional differentiation
up-regulation of functional differentiation
upregulation of functional differentiation
A process in which a protein is transported to, or maintained in, a location within a ciliary membrane.
protein localisation in ciliary membrane
protein localisation to ciliary membrane
protein localization in ciliary membrane
protein localization to ciliary membrane
Any process that modulates the frequency, rate or extent of blood circulation.
Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation.
down regulation of hemolymph circulation
down-regulation of hemolymph circulation
negative regulation of hemolymph circulation
negative regulation of blood circulation
Any process that activates or increases the frequency, rate or extent of blood circulation.
positive regulation of hemolymph circulation
positive regulation of blood circulation
Any process that modulates the frequency, rate or extent of secretion by cell.
Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell.
negative regulation of cellular secretion
negative regulation of secretion by cell
Any process that activates or increases the frequency, rate or extent of secretion by cell.
positive regulation of cellular secretion
positive regulation of secretion by cell
Any meiotic cell cycle process that is involved in oocyte maturation.
meiotic cell cycle process involved in oocyte maturation
Any process that modulates the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation.
regulation of meiosis involved in oocyte maturation
regulation of meiotic cell cycle process involved in oocyte maturation
Any process that modulates the frequency, rate or extent of exosomal secretion.
regulation of exosomal secretory pathway
regulation of extracellular vesicular exosome secretion
regulation of exosomal protein secretion
Any process that stops, prevents or reduces the frequency, rate or extent of exosomal secretion.
down regulation of exosomal secretory pathway
down regulation of extracellular vesicular exosome secretion
down-regulation of exosomal secretory pathway
down-regulation of extracellular vesicular exosome secretion
downregulation of exosomal secretory pathway
downregulation of extracellular vesicular exosome secretion
negative regulation of exosomal secretory pathway
negative regulation of extracellular vesicular exosome secretion
negative regulation of secretion of exosome
down regulation of exosomal protein secretion
down-regulation of exosomal protein secretion
downregulation of exosomal protein secretion
inhibition of exosomal protein secretion
inhibition of exosomal secretory pathway
inhibition of extracellular vesicular exosome secretion
negative regulation of exosomal protein secretion
negative regulation of exosomal secretion
Any process that activates or increases the frequency, rate or extent of exosomal secretion.
positive regulation of exosomal secretory pathway
positive regulation of extracellular vesicular exosome secretion
positive regulation of secretion of exosome
up regulation of exosomal secretory pathway
up regulation of extracellular vesicular exosome secretion
up-regulation of exosomal secretory pathway
up-regulation of extracellular vesicular exosome secretion
upregulation of exosomal secretory pathway
upregulation of extracellular vesicular exosome secretion
activation of exosomal protein secretion
activation of exosomal secretory pathway
activation of extracellular vesicular exosome secretion
positive regulation of exosomal protein secretion
up regulation of exosomal protein secretion
up-regulation of exosomal protein secretion
upregulation of exosomal protein secretion
positive regulation of exosomal secretion
Any process that modulates the frequency, rate or extent of extracellular vesicular exosome assembly.
regulation of extracellular vesicular exosome assembly
regulation of extracellular exosome assembly
Any process that stops, prevents or reduces the frequency, rate or extent of extracellular vesicular exosome assembly.
down regulation of extracellular vesicular exosome assembly
down-regulation of extracellular vesicular exosome assembly
downregulation of extracellular vesicular exosome assembly
negative regulation of extracellular vesicular exosome assembly
inhibition of extracellular vesicular exosome assembly
negative regulation of extracellular exosome assembly
Any process that activates or increases the frequency, rate or extent of extracellular vesicular exosome assembly.
up regulation of extracellular vesicular exosome assembly
up-regulation of extracellular vesicular exosome assembly
upregulation of extracellular vesicular exosome assembly
activation of extracellular vesicular exosome assembly
positive regulation of extracellular vesicular exosome assembly
positive regulation of extracellular exosome assembly
Any vesicle that is part of the extracellular region.
Any process that modulates the frequency, rate or extent of protein localization to cilium.
regulation of protein localization to cilium
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium.
down regulation of protein localization to cilium
down-regulation of protein localization to cilium
downregulation of protein localization to cilium
inhibition of protein localization to cilium
negative regulation of protein localization to cilium
Any process that activates or increases the frequency, rate or extent of protein localization to cilium.
up regulation of protein localization to cilium
up-regulation of protein localization to cilium
upregulation of protein localization to cilium
activation of protein localization to cilium
positive regulation of protein localization to cilium
Any process that modulates the frequency, rate or extent of protein localization to ciliary membrane.
regulation of protein localisation in ciliary membrane
regulation of protein localisation to ciliary membrane
regulation of protein localization in ciliary membrane
regulation of protein localization to ciliary membrane
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to ciliary membrane.
down regulation of protein localisation in ciliary membrane
down regulation of protein localisation to ciliary membrane
down regulation of protein localization in ciliary membrane
down regulation of protein localization to ciliary membrane
down-regulation of protein localisation in ciliary membrane
down-regulation of protein localisation to ciliary membrane
down-regulation of protein localization in ciliary membrane
down-regulation of protein localization to ciliary membrane
downregulation of protein localisation in ciliary membrane
downregulation of protein localisation to ciliary membrane
downregulation of protein localization in ciliary membrane
downregulation of protein localization to ciliary membrane
negative regulation of protein localisation in ciliary membrane
negative regulation of protein localisation to ciliary membrane
negative regulation of protein localization in ciliary membrane
inhibition of protein localisation in ciliary membrane
inhibition of protein localisation to ciliary membrane
inhibition of protein localization in ciliary membrane
inhibition of protein localization to ciliary membrane
negative regulation of protein localization to ciliary membrane
Any process that activates or increases the frequency, rate or extent of protein localization to ciliary membrane.
positive regulation of protein localisation in ciliary membrane
positive regulation of protein localisation to ciliary membrane
positive regulation of protein localization in ciliary membrane
up regulation of protein localisation in ciliary membrane
up regulation of protein localisation to ciliary membrane
up regulation of protein localization in ciliary membrane
up regulation of protein localization to ciliary membrane
up-regulation of protein localisation in ciliary membrane
up-regulation of protein localisation to ciliary membrane
up-regulation of protein localization in ciliary membrane
up-regulation of protein localization to ciliary membrane
upregulation of protein localisation in ciliary membrane
upregulation of protein localisation to ciliary membrane
upregulation of protein localization in ciliary membrane
upregulation of protein localization to ciliary membrane
activation of protein localisation in ciliary membrane
activation of protein localisation to ciliary membrane
activation of protein localization in ciliary membrane
activation of protein localization to ciliary membrane
positive regulation of protein localization to ciliary membrane
The process whose specific outcome is the progression of a substantia propria of cornea over time, from its formation to the mature structure.
substantia propria of cornea development
The process whose specific outcome is the progression of an esophagus over time, from its formation to the mature structure.
Any process that modulates the frequency, rate or extent of hemopoiesis.
An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype.
Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis.
down regulation of blood cell biosynthesis
down-regulation of blood cell biosynthesis
downregulation of blood cell biosynthesis
negative regulation of blood cell biosynthesis
negative regulation of blood cell formation
Any process that activates or increases the frequency, rate or extent of hemopoiesis.
positive regulation of blood cell biosynthesis
positive regulation of blood cell formation
up regulation of blood cell biosynthesis
up-regulation of blood cell biosynthesis
Any process that modulates the frequency, rate or extent of plasma membrane organization.
regulation of plasma membrane organisation
regulation of plasma membrane organization and biogenesis
regulation of plasma membrane organization
A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane.
protein localisation in vacuolar membrane
protein localisation to vacuolar membrane
protein localization in vacuolar membrane
protein localization to vacuolar membrane
Any process that modulates the frequency, rate or extent of cardiac conduction.
Any process that stops, prevents or reduces the frequency, rate or extent of cardiac conduction.
negative regulation of cardiac conduction
Any process that activates or increases the frequency, rate or extent of cardiac conduction.
positive regulation of cardiac conduction
Any process that modulates the frequency, rate or extent of amino acid transmembrane transport.
regulation of amino acid membrane transport
regulation of amino acid transmembrane transport
Any process that modulates the frequency, rate or extent of inorganic anion transmembrane transport.
regulation of inorganic anion membrane transport
regulation of transmembrane inorganic anion transport
regulation of inorganic anion transmembrane transport
Any process that stops, prevents or reduces the frequency, rate or extent of inorganic anion transmembrane transport.
down regulation of inorganic anion membrane transport
down regulation of inorganic anion transmembrane transport
down regulation of transmembrane inorganic anion transport
down-regulation of inorganic anion membrane transport
down-regulation of inorganic anion transmembrane transport
down-regulation of transmembrane inorganic anion transport
downregulation of inorganic anion membrane transport
downregulation of inorganic anion transmembrane transport
downregulation of transmembrane inorganic anion transport
negative regulation of inorganic anion membrane transport
negative regulation of transmembrane inorganic anion transport
inhibition of inorganic anion membrane transport
inhibition of inorganic anion transmembrane transport
inhibition of transmembrane inorganic anion transport
negative regulation of inorganic anion transmembrane transport
Any process that activates or increases the frequency, rate or extent of inorganic anion transmembrane transport.
positive regulation of inorganic anion membrane transport
positive regulation of transmembrane inorganic anion transport
up regulation of inorganic anion membrane transport
up regulation of inorganic anion transmembrane transport
up regulation of transmembrane inorganic anion transport
up-regulation of inorganic anion membrane transport
up-regulation of inorganic anion transmembrane transport
up-regulation of transmembrane inorganic anion transport
upregulation of inorganic anion membrane transport
upregulation of inorganic anion transmembrane transport
upregulation of transmembrane inorganic anion transport
activation of inorganic anion membrane transport
activation of inorganic anion transmembrane transport
activation of transmembrane inorganic anion transport
positive regulation of inorganic anion transmembrane transport
The process in which an organic acid is transported across a membrane.
Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization.
down regulation of cellular protein localisation
down regulation of cellular protein localization
down-regulation of cellular protein localisation
down-regulation of cellular protein localization
downregulation of cellular protein localisation
downregulation of cellular protein localization
negative regulation of cellular protein localisation
negative regulation of cellular protein localization
inhibition of cellular protein localisation
inhibition of cellular protein localization
negative regulation of protein localization
Any process that activates or increases the frequency, rate or extent of a protein localization.
positive regulation of cellular protein localisation
positive regulation of cellular protein localization
up regulation of cellular protein localisation
up regulation of cellular protein localization
up-regulation of cellular protein localisation
up-regulation of cellular protein localization
upregulation of cellular protein localisation
upregulation of cellular protein localization
positive regulation of protein localization
Any process that modulates the frequency, rate or extent of aorta morphogenesis.
Any process that stops, prevents or reduces the frequency, rate or extent of aorta morphogenesis.
negative regulation of aorta morphogenesis
Any process that activates or increases the frequency, rate or extent of aorta morphogenesis.
positive regulation of aorta morphogenesis
The process whose specific outcome is the progression of an extraembryonic membrane over time, from its formation to the mature structure.
Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange.
down regulation of respiratory gaseous exchange
down-regulation of respiratory gaseous exchange
downregulation of respiratory gaseous exchange
inhibition of respiratory gaseous exchange
negative regulation of respiratory gaseous exchange
Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange.
up regulation of respiratory gaseous exchange
up-regulation of respiratory gaseous exchange
upregulation of respiratory gaseous exchange
activation of respiratory gaseous exchange
positive regulation of respiratory gaseous exchange
Any process that stops, prevents or reduces the frequency, rate or extent of AV node cell action potential.
down regulation of AV node cardiac muscle cell action potential
down regulation of AV node cell action potential
down regulation of atrioventricular node cardiac muscle cell action potential
down-regulation of AV node cardiac muscle cell action potential
down-regulation of AV node cell action potential
down-regulation of atrioventricular node cardiac muscle cell action potential
downregulation of AV node cardiac muscle cell action potential
downregulation of AV node cell action potential
downregulation of atrioventricular node cardiac muscle cell action potential
negative regulation of AV node cardiac muscle cell action potential
negative regulation of atrioventricular node cardiac muscle cell action potential
inhibition of AV node cardiac muscle cell action potential
inhibition of AV node cell action potential
inhibition of atrioventricular node cardiac muscle cell action potential
negative regulation of AV node cell action potential
Any process that activates or increases the frequency, rate or extent of AV node cell action potential.
positive regulation of AV node cardiac muscle cell action potential
positive regulation of atrioventricular node cardiac muscle cell action potential
up regulation of AV node cardiac muscle cell action potential
up regulation of AV node cell action potential
up regulation of atrioventricular node cardiac muscle cell action potential
up-regulation of AV node cardiac muscle cell action potential
up-regulation of AV node cell action potential
up-regulation of atrioventricular node cardiac muscle cell action potential
upregulation of AV node cardiac muscle cell action potential
upregulation of AV node cell action potential
upregulation of atrioventricular node cardiac muscle cell action potential
activation of AV node cardiac muscle cell action potential
activation of AV node cell action potential
activation of atrioventricular node cardiac muscle cell action potential
positive regulation of AV node cell action potential
Any process that modulates the frequency, rate or extent of glial cell migration.
Any process that stops, prevents or reduces the frequency, rate or extent of glial cell migration.
negative regulation of glia cell migration
negative regulation of glial cell migration
Any process that activates or increases the frequency, rate or extent of glial cell migration.
positive regulation of glia cell migration
positive regulation of glial cell migration
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus.
Any process that activates or increases the frequency, rate or extent of vasculature development.
up regulation of vasculature development
up-regulation of vasculature development
activation of vascular system development
positive regulation of vascular system development
up regulation of vascular system development
up-regulation of vascular system development
upregulation of vascular system development
positive regulation of vasculature development
Any apoptotic process in an epithelial cell.
Any process that modulates the frequency, rate or extent of collagen fibril organization.
regulation of collagen fibril organisation
regulation of fibrillar collagen organization
regulation of collagen fibril organization
Any process that stops, prevents or reduces the frequency, rate or extent of collagen fibril organization.
down regulation of collagen fibril organisation
down regulation of collagen fibril organization
down regulation of fibrillar collagen organization
down-regulation of collagen fibril organisation
down-regulation of collagen fibril organization
down-regulation of fibrillar collagen organization
downregulation of collagen fibril organisation
downregulation of collagen fibril organization
downregulation of fibrillar collagen organization
negative regulation of collagen fibril organisation
negative regulation of fibrillar collagen organization
inhibition of collagen fibril organisation
inhibition of collagen fibril organization
inhibition of fibrillar collagen organization
negative regulation of collagen fibril organization
Any process that activates or increases the frequency, rate or extent of collagen fibril organization.
positive regulation of collagen fibril organisation
positive regulation of fibrillar collagen organization
up regulation of collagen fibril organisation
up regulation of collagen fibril organization
up regulation of fibrillar collagen organization
up-regulation of collagen fibril organisation
up-regulation of collagen fibril organization
up-regulation of fibrillar collagen organization
upregulation of collagen fibril organisation
upregulation of collagen fibril organization
upregulation of fibrillar collagen organization
activation of collagen fibril organisation
activation of collagen fibril organization
activation of fibrillar collagen organization
positive regulation of collagen fibril organization
Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process.
regulation of epitheliocyte apoptotic process
regulation of epithelial cell apoptotic process
Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process.
down regulation of epithelial cell apoptotic process
down regulation of epitheliocyte apoptotic process
down-regulation of epithelial cell apoptotic process
down-regulation of epitheliocyte apoptotic process
downregulation of epithelial cell apoptotic process
downregulation of epitheliocyte apoptotic process
negative regulation of epitheliocyte apoptotic process
down regulation of epithelial cell apoptosis
down regulation of epitheliocyte apoptosis
down-regulation of epithelial cell apoptosis
down-regulation of epitheliocyte apoptosis
downregulation of epithelial cell apoptosis
downregulation of epitheliocyte apoptosis
inhibition of epithelial cell apoptotic process
inhibition of epitheliocyte apoptotic process
negative regulation of epithelial cell apoptosis
negative regulation of epitheliocyte apoptosis
negative regulation of epithelial cell apoptotic process
Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process.
positive regulation of epitheliocyte apoptotic process
up regulation of epithelial cell apoptotic process
up regulation of epitheliocyte apoptotic process
up-regulation of epithelial cell apoptotic process
up-regulation of epitheliocyte apoptotic process
upregulation of epithelial cell apoptotic process
upregulation of epitheliocyte apoptotic process
activation of epithelial cell apoptotic process
activation of epitheliocyte apoptotic process
positive regulation of epithelial cell apoptosis
positive regulation of epitheliocyte apoptosis
up regulation of epithelial cell apoptosis
up regulation of epitheliocyte apoptosis
up-regulation of epithelial cell apoptosis
up-regulation of epitheliocyte apoptosis
upregulation of epithelial cell apoptosis
positive regulation of epithelial cell apoptotic process
Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain.
down regulation of sensory perception of pain
down-regulation of sensory perception of pain
downregulation of sensory perception of pain
down regulation of perception of physiological pain
down-regulation of perception of physiological pain
downregulation of perception of physiological pain
inhibition of perception of physiological pain
inhibition of sensory perception of pain
negative regulation of perception of physiological pain
negative regulation of sensory perception of pain
Any process that activates or increases the frequency, rate or extent of sensory perception of pain.
up regulation of sensory perception of pain
up-regulation of sensory perception of pain
upregulation of sensory perception of pain
activation of perception of physiological pain
activation of sensory perception of pain
positive regulation of perception of physiological pain
up regulation of perception of physiological pain
up-regulation of perception of physiological pain
upregulation of perception of physiological pain
positive regulation of sensory perception of pain
Any process that modulates the frequency, rate or extent of trophectodermal cell proliferation.
regulation of trophectoderm cell proliferation
regulation of trophectodermal cell proliferation
Any process that stops, prevents or reduces the frequency, rate or extent of trophectodermal cell proliferation.
down regulation of trophectoderm cell proliferation
down regulation of trophectodermal cell proliferation
down-regulation of trophectoderm cell proliferation
down-regulation of trophectodermal cell proliferation
downregulation of trophectoderm cell proliferation
downregulation of trophectodermal cell proliferation
negative regulation of trophectoderm cell proliferation
inhibition of trophectoderm cell proliferation
inhibition of trophectodermal cell proliferation
negative regulation of trophectodermal cell proliferation
Any process that activates or increases the frequency, rate or extent of trophectodermal cell proliferation.
positive regulation of trophectoderm cell proliferation
up regulation of trophectoderm cell proliferation
up regulation of trophectodermal cell proliferation
up-regulation of trophectoderm cell proliferation
up-regulation of trophectodermal cell proliferation
upregulation of trophectoderm cell proliferation
upregulation of trophectodermal cell proliferation
activation of trophectoderm cell proliferation
activation of trophectodermal cell proliferation
positive regulation of trophectodermal cell proliferation
Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation.
down regulation of meiotic cell cycle process involved in oocyte maturation
down-regulation of meiotic cell cycle process involved in oocyte maturation
downregulation of meiotic cell cycle process involved in oocyte maturation
inhibition of meiotic cell cycle process involved in oocyte maturation
negative regulation of meiotic cell cycle process involved in oocyte maturation
Any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation.
up regulation of meiotic cell cycle process involved in oocyte maturation
up-regulation of meiotic cell cycle process involved in oocyte maturation
upregulation of meiotic cell cycle process involved in oocyte maturation
activation of meiotic cell cycle process involved in oocyte maturation
positive regulation of meiotic cell cycle process involved in oocyte maturation
Any process that modulates the frequency, rate or extent of bleb assembly.
Any process that stops, prevents or reduces the frequency, rate or extent of bleb assembly.
Any process that activates or increases the frequency, rate or extent of bleb assembly.
Any process that modulates the frequency, rate or extent of adipose tissue development.
regulation of adipose tissue development
Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development.
down regulation of adipose tissue development
down-regulation of adipose tissue development
downregulation of adipose tissue development
inhibition of adipose tissue development
negative regulation of adipose tissue development
Any process that activates or increases the frequency, rate or extent of adipose tissue development.
up regulation of adipose tissue development
up-regulation of adipose tissue development
upregulation of adipose tissue development
activation of adipose tissue development
positive regulation of adipose tissue development
Any process that modulates the frequency, rate or extent of skeletal muscle hypertrophy.
regulation of skeletal muscle hypertrophy
Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle hypertrophy.
down regulation of skeletal muscle hypertrophy
down-regulation of skeletal muscle hypertrophy
downregulation of skeletal muscle hypertrophy
inhibition of skeletal muscle hypertrophy
negative regulation of skeletal muscle hypertrophy
Any process that activates or increases the frequency, rate or extent of skeletal muscle hypertrophy.
up regulation of skeletal muscle hypertrophy
up-regulation of skeletal muscle hypertrophy
upregulation of skeletal muscle hypertrophy
activation of skeletal muscle hypertrophy
positive regulation of skeletal muscle hypertrophy
The cell cortex of the leading edge of a cell.
peripheral cytoplasm of cell leading edge
peripheral cytoplasm of leading edge of cell
Any process that modulates the frequency, rate or extent of gastric mucosal blood circulation.
regulation of stomach mucosal blood circulation
regulation of gastric mucosal blood circulation
Any process that stops, prevents or reduces the frequency, rate or extent of gastric mucosal blood circulation.
down regulation of gastric mucosal blood circulation
down regulation of stomach mucosal blood circulation
down-regulation of gastric mucosal blood circulation
down-regulation of stomach mucosal blood circulation
downregulation of gastric mucosal blood circulation
downregulation of stomach mucosal blood circulation
negative regulation of stomach mucosal blood circulation
inhibition of gastric mucosal blood circulation
inhibition of stomach mucosal blood circulation
negative regulation of gastric mucosal blood circulation
Any process that activates or increases the frequency, rate or extent of gastric mucosal blood circulation.
positive regulation of stomach mucosal blood circulation
up regulation of gastric mucosal blood circulation
up regulation of stomach mucosal blood circulation
up-regulation of gastric mucosal blood circulation
up-regulation of stomach mucosal blood circulation
upregulation of gastric mucosal blood circulation
upregulation of stomach mucosal blood circulation
activation of gastric mucosal blood circulation
activation of stomach mucosal blood circulation
positive regulation of gastric mucosal blood circulation
Any process that modulates the frequency, rate or extent of protein localization to cell periphery.
regulation of protein localization to cell periphery
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery.
down regulation of protein localization to cell periphery
down-regulation of protein localization to cell periphery
downregulation of protein localization to cell periphery
inhibition of protein localization to cell periphery
negative regulation of protein localization to cell periphery
Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery.
up regulation of protein localization to cell periphery
up-regulation of protein localization to cell periphery
upregulation of protein localization to cell periphery
activation of protein localization to cell periphery
positive regulation of protein localization to cell periphery
Any process that modulates the frequency, rate or extent of neuromuscular junction development.
regulation of neuromuscular junction organization
regulation of neuromuscular junction stability
regulation of neuromuscular junction development
Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular junction development.
down regulation of neuromuscular junction development
down regulation of neuromuscular junction organization
down-regulation of neuromuscular junction development
down-regulation of neuromuscular junction organization
downregulation of neuromuscular junction development
downregulation of neuromuscular junction organization
negative regulation of neuromuscular junction organization
inhibition of neuromuscular junction development
inhibition of neuromuscular junction organization
down regulation of neuromuscular junction stability
down-regulation of neuromuscular junction stability
downregulation of neuromuscular junction stability
inhibition of neuromuscular junction stability
negative regulation of neuromuscular junction stability
negative regulation of neuromuscular junction development
Any process that activates or increases the frequency, rate or extent of neuromuscular junction development.
positive regulation of neuromuscular junction organization
up regulation of neuromuscular junction development
up regulation of neuromuscular junction organization
up-regulation of neuromuscular junction development
up-regulation of neuromuscular junction organization
upregulation of neuromuscular junction development
upregulation of neuromuscular junction organization
activation of neuromuscular junction development
activation of neuromuscular junction organization
activation of neuromuscular junction stability
positive regulation of neuromuscular junction stability
up regulation of neuromuscular junction stability
up-regulation of neuromuscular junction stability
upregulation of neuromuscular junction stability
positive regulation of neuromuscular junction development
Any process that modulates the frequency, rate or extent of secretory granule organization.
regulation of secretory granule organisation
regulation of secretory granule organization and biogenesis
regulation of secretory granule organization
Any process that stops, prevents or reduces the frequency, rate or extent of secretory granule organization.
down regulation of secretory granule organisation
down regulation of secretory granule organization
down-regulation of secretory granule organisation
down-regulation of secretory granule organization
downregulation of secretory granule organisation
downregulation of secretory granule organization
negative regulation of secretory granule organisation
inhibition of secretory granule organisation
inhibition of secretory granule organization
down regulation of secretory granule organization and biogenesis
down-regulation of secretory granule organization and biogenesis
downregulation of secretory granule organization and biogenesis
inhibition of secretory granule organization and biogenesis
negative regulation of secretory granule organization and biogenesis
negative regulation of secretory granule organization
Any process that activates or increases the frequency, rate or extent of secretory granule organization.
positive regulation of secretory granule organisation
up regulation of secretory granule organisation
up regulation of secretory granule organization
up-regulation of secretory granule organisation
up-regulation of secretory granule organization
upregulation of secretory granule organisation
upregulation of secretory granule organization
activation of secretory granule organisation
activation of secretory granule organization
activation of secretory granule organization and biogenesis
positive regulation of secretory granule organization and biogenesis
up regulation of secretory granule organization and biogenesis
up-regulation of secretory granule organization and biogenesis
upregulation of secretory granule organization and biogenesis
positive regulation of secretory granule organization
Any process that modulates the frequency, rate or extent of cardiac ventricle development.
regulation of cardiac ventricle development
Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle development.
down regulation of cardiac ventricle development
down-regulation of cardiac ventricle development
downregulation of cardiac ventricle development
inhibition of cardiac ventricle development
negative regulation of cardiac ventricle development
Any process that activates or increases the frequency, rate or extent of cardiac ventricle development.
up regulation of cardiac ventricle development
up-regulation of cardiac ventricle development
upregulation of cardiac ventricle development
activation of cardiac ventricle development
positive regulation of cardiac ventricle development
Any process that stops, prevents or reduces the frequency, rate or extent of neuronal action potential.
down regulation of neuronal action potential
down-regulation of neuronal action potential
downregulation of neuronal action potential
down regulation of generation of action potential
down-regulation of generation of action potential
downregulation of generation of action potential
inhibition of generation of action potential
negative regulation of generation of action potential
negative regulation of neuronal action potential
Any process that activates or increases the frequency, rate or extent of neuronal action potential.
up regulation of neuronal action potential
up-regulation of neuronal action potential
upregulation of neuronal action potential
activation of generation of action potential
positive regulation of generation of action potential
up regulation of generation of action potential
up-regulation of generation of action potential
upregulation of generation of action potential
positive regulation of neuronal action potential
A process in which a protein is transported to, or maintained in, a location within a ciliary transition zone.
protein localisation in ciliary transition zone
protein localisation to ciliary transition zone
protein localization in ciliary transition zone
protein localization to ciliary transition zone
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus.
Any process that modulates the frequency, rate or extent of fat cell apoptotic process.
regulation of adipocyte apoptotic process
regulation of adipose cell apoptotic process
regulation of fat cell apoptotic process
Any process that stops, prevents or reduces the frequency, rate or extent of fat cell apoptotic process.
down regulation of adipocyte apoptotic process
down regulation of adipose cell apoptotic process
down regulation of fat cell apoptotic process
down-regulation of adipocyte apoptotic process
down-regulation of adipose cell apoptotic process
down-regulation of fat cell apoptotic process
downregulation of adipocyte apoptotic process
downregulation of adipose cell apoptotic process
downregulation of fat cell apoptotic process
negative regulation of adipocyte apoptotic process
negative regulation of adipose cell apoptotic process
down regulation of adipose cell apoptosis
down-regulation of adipose cell apoptosis
downregulation of adipose cell apoptosis
inhibition of adipocyte apoptotic process
inhibition of adipose cell apoptotic process
inhibition of fat cell apoptotic process
negative regulation of adipocyte apoptosis
negative regulation of adipose cell apoptosis
negative regulation of fat cell apoptosis
negative regulation of fat cell apoptotic process
Any process that activates or increases the frequency, rate or extent of fat cell apoptotic process.
positive regulation of adipocyte apoptotic process
positive regulation of adipose cell apoptotic process
up regulation of adipocyte apoptotic process
up regulation of adipose cell apoptotic process
up regulation of fat cell apoptotic process
up-regulation of adipocyte apoptotic process
up-regulation of adipose cell apoptotic process
up-regulation of fat cell apoptotic process
upregulation of adipocyte apoptotic process
upregulation of adipose cell apoptotic process
upregulation of fat cell apoptotic process
activation of adipocyte apoptotic process
activation of adipose cell apoptotic process
activation of fat cell apoptotic process
positive regulation of adipocyte apoptosis
positive regulation of adipose cell apoptosis
positive regulation of fat cell apoptosis
positive regulation of fat cell apoptotic process
Any process that modulates the frequency, rate or extent of somatic stem cell division.
regulation of somatic stem cell division
Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell division.
down regulation of somatic stem cell division
down regulation of somatic stem cell renewal
down-regulation of somatic stem cell division
down-regulation of somatic stem cell renewal
downregulation of somatic stem cell division
downregulation of somatic stem cell renewal
negative regulation of somatic stem cell renewal
inhibition of somatic stem cell division
negative regulation of somatic stem cell division
Any process that activates or increases the frequency, rate or extent of somatic stem cell division.
positive regulation of somatic stem cell renewal
up regulation of somatic stem cell division
up regulation of somatic stem cell renewal
up-regulation of somatic stem cell division
up-regulation of somatic stem cell renewal
upregulation of somatic stem cell division
upregulation of somatic stem cell renewal
activation of somatic stem cell division
positive regulation of somatic stem cell division
Any process that modulates the frequency, rate or extent of cytoplasmic translational initiation.
regulation of cytoplasmic translational initiation
Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational initiation.
down regulation of cytoplasmic translational initiation
down-regulation of cytoplasmic translational initiation
downregulation of cytoplasmic translational initiation
inhibition of cytoplasmic translational initiation
negative regulation of cytoplasmic translational initiation
Any process that activates or increases the frequency, rate or extent of cytoplasmic translational initiation.
up regulation of cytoplasmic translational initiation
up-regulation of cytoplasmic translational initiation
upregulation of cytoplasmic translational initiation
activation of cytoplasmic translational initiation
positive regulation of cytoplasmic translational initiation
The developmental process by which a midbrain is generated and organized.
Any process that modulates the frequency, rate or extent of acinar cell proliferation.
regulation of acinous cell proliferation
Any process that stops, prevents or reduces the frequency, rate or extent of acinar cell proliferation.
down regulation of acinar cell proliferation
down regulation of acinic cell proliferation
down regulation of acinous cell proliferation
down-regulation of acinar cell proliferation
down-regulation of acinic cell proliferation
down-regulation of acinous cell proliferation
downregulation of acinar cell proliferation
downregulation of acinic cell proliferation
downregulation of acinous cell proliferation
negative regulation of acinic cell proliferation
negative regulation of acinous cell proliferation
inhibition of acinous cell proliferation
negative regulation of acinar cell proliferation
Any process that activates or increases the frequency, rate or extent of acinar cell proliferation.
positive regulation of acinic cell proliferation
positive regulation of acinous cell proliferation
up regulation of acinar cell proliferation
up regulation of acinic cell proliferation
up regulation of acinous cell proliferation
up-regulation of acinar cell proliferation
up-regulation of acinic cell proliferation
up-regulation of acinous cell proliferation
upregulation of acinar cell proliferation
upregulation of acinic cell proliferation
upregulation of acinous cell proliferation
activation of acinous cell proliferation
positive regulation of acinar cell proliferation
Any process that modulates the frequency, rate or extent of vascular smooth muscle cell proliferation.
regulation of vascular smooth muscle cell proliferation
regulation of vascular associated smooth muscle cell proliferation
Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation.
down regulation of vascular smooth muscle cell proliferation
down-regulation of vascular smooth muscle cell proliferation
downregulation of vascular smooth muscle cell proliferation
negative regulation of VSMC proliferation
negative regulation of vascular smooth muscle cell proliferation
inhibition of vascular smooth muscle cell proliferation
negative regulation of vascular associated smooth muscle cell proliferation
Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation.
positive regulation of VSMC proliferation
positive regulation of vascular smooth muscle cell proliferation
up regulation of vascular smooth muscle cell proliferation
up-regulation of vascular smooth muscle cell proliferation
upregulation of vascular smooth muscle cell proliferation
activation of vascular smooth muscle cell proliferation
positive regulation of vascular associated smooth muscle cell proliferation
The orderly movement of a vascular associated smooth muscle cell from one site to another.
vascular associated smooth muscle cell migration
Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development.
down regulation of apoptotic cell death involved in anatomical structure development
down regulation of apoptotic cell death involved in development of an anatomical structure
down regulation of apoptotic process involved in anatomical structure development
down regulation of apoptotic process involved in development
down regulation of apoptotic process involved in development of an anatomical structure
down regulation of apoptotic programmed cell death involved in anatomical structure development
down regulation of apoptotic programmed cell death involved in development of an anatomical structure
down regulation of programmed cell death by apoptosis involved in anatomical structure development
down regulation of programmed cell death by apoptosis involved in development of an anatomical structure
down-regulation of apoptotic cell death involved in anatomical structure development
down-regulation of apoptotic cell death involved in development of an anatomical structure
down-regulation of apoptotic process involved in anatomical structure development
down-regulation of apoptotic process involved in development
down-regulation of apoptotic process involved in development of an anatomical structure
down-regulation of apoptotic programmed cell death involved in anatomical structure development
down-regulation of apoptotic programmed cell death involved in development of an anatomical structure
down-regulation of programmed cell death by apoptosis involved in anatomical structure development
down-regulation of programmed cell death by apoptosis involved in development of an anatomical structure
downregulation of apoptotic cell death involved in anatomical structure development
downregulation of apoptotic cell death involved in development of an anatomical structure
downregulation of apoptotic process involved in anatomical structure development
downregulation of apoptotic process involved in development
downregulation of apoptotic process involved in development of an anatomical structure
downregulation of apoptotic programmed cell death involved in anatomical structure development
downregulation of apoptotic programmed cell death involved in development of an anatomical structure
downregulation of programmed cell death by apoptosis involved in anatomical structure development
downregulation of programmed cell death by apoptosis involved in development of an anatomical structure
negative regulation of apoptotic cell death involved in anatomical structure development
negative regulation of apoptotic cell death involved in development of an anatomical structure
negative regulation of apoptotic process involved in anatomical structure development
negative regulation of apoptotic process involved in development of an anatomical structure
negative regulation of apoptotic programmed cell death involved in anatomical structure development
negative regulation of apoptotic programmed cell death involved in development of an anatomical structure
negative regulation of programmed cell death by apoptosis involved in anatomical structure development
negative regulation of programmed cell death by apoptosis involved in development of an anatomical structure
down regulation of activation of apoptosis involved in anatomical structure development
down regulation of activation of apoptosis involved in development of an anatomical structure
down regulation of apoptosis involved in anatomical structure development
down regulation of apoptosis involved in development of an anatomical structure
down regulation of apoptosis signaling involved in anatomical structure development
down regulation of apoptosis signaling involved in development of an anatomical structure
down regulation of apoptotic program involved in anatomical structure development
down regulation of apoptotic program involved in development of an anatomical structure
down regulation of type I programmed cell death involved in anatomical structure development
down regulation of type I programmed cell death involved in development of an anatomical structure
down-regulation of activation of apoptosis involved in anatomical structure development
down-regulation of activation of apoptosis involved in development of an anatomical structure
down-regulation of apoptosis involved in anatomical structure development
down-regulation of apoptosis involved in development of an anatomical structure
down-regulation of apoptosis signaling involved in anatomical structure development
down-regulation of apoptosis signaling involved in development of an anatomical structure
down-regulation of apoptotic program involved in anatomical structure development
down-regulation of apoptotic program involved in development of an anatomical structure
down-regulation of type I programmed cell death involved in anatomical structure development
down-regulation of type I programmed cell death involved in development of an anatomical structure
downregulation of activation of apoptosis involved in anatomical structure development
downregulation of activation of apoptosis involved in development of an anatomical structure
downregulation of apoptosis involved in anatomical structure development
downregulation of apoptosis involved in development of an anatomical structure
downregulation of apoptosis signaling involved in anatomical structure development
downregulation of apoptosis signaling involved in development of an anatomical structure
downregulation of apoptotic program involved in anatomical structure development
downregulation of apoptotic program involved in development of an anatomical structure
downregulation of type I programmed cell death involved in anatomical structure development
downregulation of type I programmed cell death involved in development of an anatomical structure
inhibition of activation of apoptosis involved in anatomical structure development
inhibition of activation of apoptosis involved in development of an anatomical structure
inhibition of apoptosis involved in anatomical structure development
inhibition of apoptosis involved in development of an anatomical structure
inhibition of apoptosis signaling involved in anatomical structure development
inhibition of apoptosis signaling involved in development of an anatomical structure
inhibition of apoptotic cell death involved in anatomical structure development
inhibition of apoptotic cell death involved in development of an anatomical structure
inhibition of apoptotic process involved in anatomical structure development
inhibition of apoptotic process involved in development
inhibition of apoptotic process involved in development of an anatomical structure
inhibition of apoptotic program involved in anatomical structure development
inhibition of apoptotic program involved in development of an anatomical structure
inhibition of apoptotic programmed cell death involved in anatomical structure development
inhibition of apoptotic programmed cell death involved in development of an anatomical structure
inhibition of programmed cell death by apoptosis involved in anatomical structure development
inhibition of programmed cell death by apoptosis involved in development of an anatomical structure
inhibition of type I programmed cell death involved in anatomical structure development
inhibition of type I programmed cell death involved in development of an anatomical structure
negative regulation of activation of apoptosis involved in anatomical structure development
negative regulation of activation of apoptosis involved in development of an anatomical structure
negative regulation of apoptosis involved in anatomical structure development
negative regulation of apoptosis involved in development of an anatomical structure
negative regulation of apoptosis signaling involved in anatomical structure development
negative regulation of apoptosis signaling involved in development of an anatomical structure
negative regulation of apoptotic program involved in anatomical structure development
negative regulation of apoptotic program involved in development of an anatomical structure
negative regulation of type I programmed cell death involved in anatomical structure development
negative regulation of type I programmed cell death involved in development of an anatomical structure
down regulation of apoptosis activator activity involved in anatomical structure development
down regulation of apoptosis activator activity involved in development of an anatomical structure
down regulation of commitment to apoptosis involved in anatomical structure development
down regulation of commitment to apoptosis involved in development of an anatomical structure
down regulation of induction of apoptosis by p53 involved in anatomical structure development
down regulation of induction of apoptosis by p53 involved in development of an anatomical structure
down regulation of induction of apoptosis involved in anatomical structure development
down regulation of induction of apoptosis involved in development of an anatomical structure
down regulation of signaling (initiator) caspase activity involved in anatomical structure development
down regulation of signaling (initiator) caspase activity involved in development of an anatomical structure
down-regulation of apoptosis activator activity involved in anatomical structure development
down-regulation of apoptosis activator activity involved in development of an anatomical structure
down-regulation of commitment to apoptosis involved in anatomical structure development
down-regulation of commitment to apoptosis involved in development of an anatomical structure
down-regulation of induction of apoptosis by p53 involved in anatomical structure development
down-regulation of induction of apoptosis by p53 involved in development of an anatomical structure
down-regulation of induction of apoptosis involved in anatomical structure development
down-regulation of induction of apoptosis involved in development of an anatomical structure
down-regulation of signaling (initiator) caspase activity involved in anatomical structure development
down-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure
downregulation of apoptosis activator activity involved in anatomical structure development
downregulation of apoptosis activator activity involved in development of an anatomical structure
downregulation of commitment to apoptosis involved in anatomical structure development
downregulation of commitment to apoptosis involved in development of an anatomical structure
downregulation of induction of apoptosis by p53 involved in anatomical structure development
downregulation of induction of apoptosis by p53 involved in development of an anatomical structure
downregulation of induction of apoptosis involved in anatomical structure development
downregulation of induction of apoptosis involved in development of an anatomical structure
downregulation of signaling (initiator) caspase activity involved in anatomical structure development
downregulation of signaling (initiator) caspase activity involved in development of an anatomical structure
inhibition of apoptosis activator activity involved in anatomical structure development
inhibition of apoptosis activator activity involved in development of an anatomical structure
inhibition of commitment to apoptosis involved in anatomical structure development
inhibition of commitment to apoptosis involved in development of an anatomical structure
inhibition of induction of apoptosis by p53 involved in anatomical structure development
inhibition of induction of apoptosis by p53 involved in development of an anatomical structure
inhibition of induction of apoptosis involved in anatomical structure development
inhibition of induction of apoptosis involved in development of an anatomical structure
inhibition of signaling (initiator) caspase activity involved in anatomical structure development
inhibition of signaling (initiator) caspase activity involved in development of an anatomical structure
negative regulation of apoptosis activator activity involved in anatomical structure development
negative regulation of apoptosis activator activity involved in development of an anatomical structure
negative regulation of commitment to apoptosis involved in anatomical structure development
negative regulation of commitment to apoptosis involved in development of an anatomical structure
negative regulation of induction of apoptosis by p53 involved in anatomical structure development
negative regulation of induction of apoptosis by p53 involved in development of an anatomical structure
negative regulation of induction of apoptosis involved in anatomical structure development
negative regulation of induction of apoptosis involved in development of an anatomical structure
negative regulation of signaling (initiator) caspase activity involved in anatomical structure development
negative regulation of signaling (initiator) caspase activity involved in development of an anatomical structure
U4PR86 in PMID:22801495 inferred from mutant phenotype
negative regulation of apoptotic process involved in development
Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development.
positive regulation of apoptotic cell death involved in anatomical structure development
positive regulation of apoptotic cell death involved in development of an anatomical structure
positive regulation of apoptotic process involved in anatomical structure development
positive regulation of apoptotic process involved in development of an anatomical structure
positive regulation of apoptotic programmed cell death involved in anatomical structure development
positive regulation of apoptotic programmed cell death involved in development of an anatomical structure
positive regulation of programmed cell death by apoptosis involved in anatomical structure development
positive regulation of programmed cell death by apoptosis involved in development of an anatomical structure
up regulation of apoptotic cell death involved in anatomical structure development
up regulation of apoptotic cell death involved in development of an anatomical structure
up regulation of apoptotic process involved in anatomical structure development
up regulation of apoptotic process involved in development
up regulation of apoptotic process involved in development of an anatomical structure
up regulation of apoptotic programmed cell death involved in anatomical structure development
up regulation of apoptotic programmed cell death involved in development of an anatomical structure
up regulation of programmed cell death by apoptosis involved in anatomical structure development
up regulation of programmed cell death by apoptosis involved in development of an anatomical structure
up-regulation of apoptotic cell death involved in anatomical structure development
up-regulation of apoptotic cell death involved in development of an anatomical structure
up-regulation of apoptotic process involved in anatomical structure development
up-regulation of apoptotic process involved in development
up-regulation of apoptotic process involved in development of an anatomical structure
up-regulation of apoptotic programmed cell death involved in anatomical structure development
up-regulation of apoptotic programmed cell death involved in development of an anatomical structure
up-regulation of programmed cell death by apoptosis involved in anatomical structure development
up-regulation of programmed cell death by apoptosis involved in development of an anatomical structure
upregulation of apoptotic cell death involved in anatomical structure development
upregulation of apoptotic cell death involved in development of an anatomical structure
upregulation of apoptotic process involved in anatomical structure development
upregulation of apoptotic process involved in development
upregulation of apoptotic process involved in development of an anatomical structure
upregulation of apoptotic programmed cell death involved in anatomical structure development
upregulation of apoptotic programmed cell death involved in development of an anatomical structure
upregulation of programmed cell death by apoptosis involved in anatomical structure development
upregulation of programmed cell death by apoptosis involved in development of an anatomical structure
activation of activation of apoptosis involved in anatomical structure development
activation of activation of apoptosis involved in development of an anatomical structure
activation of apoptosis signaling involved in anatomical structure development
activation of apoptosis signaling involved in development of an anatomical structure
activation of apoptotic cell death involved in anatomical structure development
activation of apoptotic cell death involved in development of an anatomical structure
activation of apoptotic process involved in anatomical structure development
activation of apoptotic process involved in development
activation of apoptotic process involved in development of an anatomical structure
activation of apoptotic program involved in anatomical structure development
activation of apoptotic program involved in development of an anatomical structure
activation of apoptotic programmed cell death involved in anatomical structure development
activation of apoptotic programmed cell death involved in development of an anatomical structure
activation of programmed cell death by apoptosis involved in anatomical structure development
activation of programmed cell death by apoptosis involved in development of an anatomical structure
activation of type I programmed cell death involved in anatomical structure development
activation of type I programmed cell death involved in development of an anatomical structure
positive regulation of activation of apoptosis involved in anatomical structure development
positive regulation of activation of apoptosis involved in development of an anatomical structure
positive regulation of apoptosis involved in anatomical structure development
positive regulation of apoptosis involved in development of an anatomical structure
positive regulation of apoptosis signaling involved in anatomical structure development
positive regulation of apoptosis signaling involved in development of an anatomical structure
positive regulation of apoptotic program involved in anatomical structure development
positive regulation of apoptotic program involved in development of an anatomical structure
positive regulation of type I programmed cell death involved in anatomical structure development
positive regulation of type I programmed cell death involved in development of an anatomical structure
up regulation of activation of apoptosis involved in anatomical structure development
up regulation of activation of apoptosis involved in development of an anatomical structure
up regulation of apoptosis involved in anatomical structure development
up regulation of apoptosis involved in development of an anatomical structure
up regulation of apoptosis signaling involved in anatomical structure development
up regulation of apoptosis signaling involved in development of an anatomical structure
up regulation of apoptotic program involved in anatomical structure development
up regulation of apoptotic program involved in development of an anatomical structure
up regulation of type I programmed cell death involved in anatomical structure development
up regulation of type I programmed cell death involved in development of an anatomical structure
up-regulation of activation of apoptosis involved in anatomical structure development
up-regulation of activation of apoptosis involved in development of an anatomical structure
up-regulation of apoptosis involved in anatomical structure development
up-regulation of apoptosis involved in development of an anatomical structure
up-regulation of apoptosis signaling involved in anatomical structure development
up-regulation of apoptosis signaling involved in development of an anatomical structure
up-regulation of apoptotic program involved in anatomical structure development
up-regulation of apoptotic program involved in development of an anatomical structure
up-regulation of type I programmed cell death involved in anatomical structure development
up-regulation of type I programmed cell death involved in development of an anatomical structure
upregulation of activation of apoptosis involved in anatomical structure development
upregulation of activation of apoptosis involved in development of an anatomical structure
upregulation of apoptosis involved in anatomical structure development
upregulation of apoptosis involved in development of an anatomical structure
upregulation of apoptosis signaling involved in anatomical structure development
upregulation of apoptosis signaling involved in development of an anatomical structure
upregulation of apoptotic program involved in anatomical structure development
upregulation of apoptotic program involved in development of an anatomical structure
upregulation of type I programmed cell death involved in anatomical structure development
upregulation of type I programmed cell death involved in development of an anatomical structure
activation of apoptosis activator activity involved in anatomical structure development
activation of apoptosis activator activity involved in development of an anatomical structure
activation of commitment to apoptosis involved in anatomical structure development
activation of commitment to apoptosis involved in development of an anatomical structure
activation of induction of apoptosis by p53 involved in anatomical structure development
activation of induction of apoptosis by p53 involved in development of an anatomical structure
activation of induction of apoptosis involved in anatomical structure development
activation of induction of apoptosis involved in development of an anatomical structure
activation of signaling (initiator) caspase activity involved in anatomical structure development
activation of signaling (initiator) caspase activity involved in development of an anatomical structure
positive regulation of apoptosis activator activity involved in anatomical structure development
positive regulation of apoptosis activator activity involved in development of an anatomical structure
positive regulation of commitment to apoptosis involved in anatomical structure development
positive regulation of commitment to apoptosis involved in development of an anatomical structure
positive regulation of induction of apoptosis by p53 involved in anatomical structure development
positive regulation of induction of apoptosis by p53 involved in development of an anatomical structure
positive regulation of induction of apoptosis involved in anatomical structure development
positive regulation of induction of apoptosis involved in development of an anatomical structure
positive regulation of signaling (initiator) caspase activity involved in anatomical structure development
positive regulation of signaling (initiator) caspase activity involved in development of an anatomical structure
up regulation of apoptosis activator activity involved in anatomical structure development
up regulation of apoptosis activator activity involved in development of an anatomical structure
up regulation of commitment to apoptosis involved in anatomical structure development
up regulation of commitment to apoptosis involved in development of an anatomical structure
up regulation of induction of apoptosis by p53 involved in anatomical structure development
up regulation of induction of apoptosis by p53 involved in development of an anatomical structure
up regulation of induction of apoptosis involved in anatomical structure development
up regulation of induction of apoptosis involved in development of an anatomical structure
up regulation of signaling (initiator) caspase activity involved in anatomical structure development
up regulation of signaling (initiator) caspase activity involved in development of an anatomical structure
up-regulation of apoptosis activator activity involved in anatomical structure development
up-regulation of apoptosis activator activity involved in development of an anatomical structure
up-regulation of commitment to apoptosis involved in anatomical structure development
up-regulation of commitment to apoptosis involved in development of an anatomical structure
up-regulation of induction of apoptosis by p53 involved in anatomical structure development
up-regulation of induction of apoptosis by p53 involved in development of an anatomical structure
up-regulation of induction of apoptosis involved in anatomical structure development
up-regulation of induction of apoptosis involved in development of an anatomical structure
up-regulation of signaling (initiator) caspase activity involved in anatomical structure development
up-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure
upregulation of apoptosis activator activity involved in anatomical structure development
upregulation of apoptosis activator activity involved in development of an anatomical structure
upregulation of commitment to apoptosis involved in anatomical structure development
upregulation of commitment to apoptosis involved in development of an anatomical structure
upregulation of induction of apoptosis by p53 involved in anatomical structure development
upregulation of induction of apoptosis by p53 involved in development of an anatomical structure
upregulation of induction of apoptosis involved in anatomical structure development
upregulation of induction of apoptosis involved in development of an anatomical structure
upregulation of signaling (initiator) caspase activity involved in anatomical structure development
upregulation of signaling (initiator) caspase activity involved in development of an anatomical structure
positive regulation of apoptotic process involved in development
Any process that modulates the frequency, rate or extent of apoptotic process involved in development.
regulation of apoptotic cell death involved in anatomical structure development
regulation of apoptotic cell death involved in development of an anatomical structure
regulation of apoptotic process involved in anatomical structure development
regulation of apoptotic process involved in development of an anatomical structure
regulation of apoptotic programmed cell death involved in anatomical structure development
regulation of apoptotic programmed cell death involved in development of an anatomical structure
regulation of programmed cell death by apoptosis involved in anatomical structure development
regulation of programmed cell death by apoptosis involved in development of an anatomical structure
regulation of activation of apoptosis involved in anatomical structure development
regulation of activation of apoptosis involved in development of an anatomical structure
regulation of apoptosis involved in anatomical structure development
regulation of apoptosis involved in development of an anatomical structure
regulation of apoptosis signaling involved in anatomical structure development
regulation of apoptosis signaling involved in development of an anatomical structure
regulation of apoptotic program involved in anatomical structure development
regulation of apoptotic program involved in development of an anatomical structure
regulation of type I programmed cell death involved in anatomical structure development
regulation of type I programmed cell death involved in development of an anatomical structure
regulation of apoptosis activator activity involved in anatomical structure development
regulation of apoptosis activator activity involved in development of an anatomical structure
regulation of commitment to apoptosis involved in anatomical structure development
regulation of commitment to apoptosis involved in development of an anatomical structure
regulation of induction of apoptosis by p53 involved in anatomical structure development
regulation of induction of apoptosis by p53 involved in development of an anatomical structure
regulation of induction of apoptosis involved in anatomical structure development
regulation of induction of apoptosis involved in development of an anatomical structure
regulation of signaling (initiator) caspase activity involved in anatomical structure development
regulation of signaling (initiator) caspase activity involved in development of an anatomical structure
Q10943 in PMID:22801495, inferred from mutant phenotype
regulation of apoptotic process involved in development
Any process that modulates the frequency, rate or extent of protein localization to nucleolus.
regulation of protein localisation in nucleolus
regulation of protein localisation to nucleolus
regulation of protein localization in nucleolus
regulation of protein localization to nucleolus
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleolus.
down regulation of protein localisation in nucleolus
down regulation of protein localisation to nucleolus
down regulation of protein localization in nucleolus
down regulation of protein localization to nucleolus
down-regulation of protein localisation in nucleolus
down-regulation of protein localisation to nucleolus
down-regulation of protein localization in nucleolus
down-regulation of protein localization to nucleolus
downregulation of protein localisation in nucleolus
downregulation of protein localisation to nucleolus
downregulation of protein localization in nucleolus
downregulation of protein localization to nucleolus
negative regulation of protein localisation in nucleolus
negative regulation of protein localisation to nucleolus
negative regulation of protein localization in nucleolus
inhibition of protein localisation in nucleolus
inhibition of protein localisation to nucleolus
inhibition of protein localization in nucleolus
inhibition of protein localization to nucleolus
negative regulation of protein localization to nucleolus
Any process that activates or increases the frequency, rate or extent of protein localization to nucleolus.
positive regulation of protein localisation in nucleolus
positive regulation of protein localisation to nucleolus
positive regulation of protein localization in nucleolus
up regulation of protein localisation in nucleolus
up regulation of protein localisation to nucleolus
up regulation of protein localization in nucleolus
up regulation of protein localization to nucleolus
up-regulation of protein localisation in nucleolus
up-regulation of protein localisation to nucleolus
up-regulation of protein localization in nucleolus
up-regulation of protein localization to nucleolus
upregulation of protein localisation in nucleolus
upregulation of protein localisation to nucleolus
upregulation of protein localization in nucleolus
upregulation of protein localization to nucleolus
activation of protein localisation in nucleolus
activation of protein localisation to nucleolus
activation of protein localization in nucleolus
activation of protein localization to nucleolus
positive regulation of protein localization to nucleolus
Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell migration.
regulation of vascular smooth muscle cell migration
regulation of vascular associated smooth muscle cell migration
Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration.
down regulation of vascular associated smooth muscle cell migration
down regulation of vascular smooth muscle cell migration
down-regulation of vascular associated smooth muscle cell migration
down-regulation of vascular smooth muscle cell migration
downregulation of vascular associated smooth muscle cell migration
downregulation of vascular smooth muscle cell migration
negative regulation of vascular smooth muscle cell migration
inhibition of vascular associated smooth muscle cell migration
inhibition of vascular smooth muscle cell migration
negative regulation of vascular associated smooth muscle cell migration
Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell migration.
positive regulation of vascular smooth muscle cell migration
up regulation of vascular associated smooth muscle cell migration
up regulation of vascular smooth muscle cell migration
up-regulation of vascular associated smooth muscle cell migration
up-regulation of vascular smooth muscle cell migration
upregulation of vascular associated smooth muscle cell migration
upregulation of vascular smooth muscle cell migration
activation of vascular associated smooth muscle cell migration
activation of vascular smooth muscle cell migration
positive regulation of vascular associated smooth muscle cell migration
The developmental process by which an intramembranous bone is generated and organized.
Any process that modulates the frequency, rate or extent of protein localization to cell cortex.
regulation of protein localisation to cell cortex
An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027.
regulation of protein localization to cell cortex
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell cortex.
down regulation of protein localisation to cell cortex
down regulation of protein localization to cell cortex
down-regulation of protein localisation to cell cortex
down-regulation of protein localization to cell cortex
downregulation of protein localisation to cell cortex
downregulation of protein localization to cell cortex
negative regulation of protein localisation to cell cortex
inhibition of protein localisation to cell cortex
inhibition of protein localization to cell cortex
negative regulation of protein localization to cell cortex
Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex.
positive regulation of protein localisation to cell cortex
up regulation of protein localisation to cell cortex
up regulation of protein localization to cell cortex
up-regulation of protein localisation to cell cortex
up-regulation of protein localization to cell cortex
upregulation of protein localisation to cell cortex
upregulation of protein localization to cell cortex
activation of protein localisation to cell cortex
activation of protein localization to cell cortex
positive regulation of protein localization to cell cortex
Any process that modulates the frequency, rate or extent of dense core granule transport.
regulation of dense core vesicle transport
cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype).
regulation of dense core granule transport
Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule transport.
down regulation of dense core granule transport
down regulation of dense core vesicle transport
down-regulation of dense core granule transport
down-regulation of dense core vesicle transport
downregulation of dense core granule transport
downregulation of dense core vesicle transport
negative regulation of dense core vesicle transport
inhibition of dense core granule transport
inhibition of dense core vesicle transport
negative regulation of dense core granule transport
Any process that activates or increases the frequency, rate or extent of dense core granule transport.
positive regulation of dense core vesicle transport
up regulation of dense core granule transport
up regulation of dense core vesicle transport
up-regulation of dense core granule transport
up-regulation of dense core vesicle transport
upregulation of dense core granule transport
upregulation of dense core vesicle transport
activation of dense core granule transport
activation of dense core vesicle transport
positive regulation of dense core granule transport
The process whose specific outcome is the progression of a serous membrane over time, from its formation to the mature structure.
The process whose specific outcome is the progression of a visceral peritoneum over time, from its formation to the mature structure.
The process whose specific outcome is the progression of a parietal peritoneum over time, from its formation to the mature structure.
The process whose specific outcome is the progression of a peritoneum over time, from its formation to the mature structure.
Any process that modulates the frequency, rate or extent of aortic smooth muscle cell differentiation.
regulation of aortic smooth muscle cell differentiation
Any process that stops, prevents or reduces the frequency, rate or extent of aortic smooth muscle cell differentiation.
down regulation of aortic smooth muscle cell differentiation
down-regulation of aortic smooth muscle cell differentiation
downregulation of aortic smooth muscle cell differentiation
inhibition of aortic smooth muscle cell differentiation
negative regulation of aortic smooth muscle cell differentiation
Any process that activates or increases the frequency, rate or extent of aortic smooth muscle cell differentiation.
up regulation of aortic smooth muscle cell differentiation
up-regulation of aortic smooth muscle cell differentiation
upregulation of aortic smooth muscle cell differentiation
activation of aortic smooth muscle cell differentiation
positive regulation of aortic smooth muscle cell differentiation
The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus.
Any process that modulates the frequency, rate or extent of cell proliferation in midbrain.
regulation of cell proliferation in mesencephalon
regulation of mesencepahalic cell proliferation
regulation of cell proliferation in midbrain
Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in midbrain.
down regulation of cell proliferation in mesencephalon
down regulation of cell proliferation in midbrain
down-regulation of cell proliferation in mesencephalon
down-regulation of cell proliferation in midbrain
downregulation of cell proliferation in mesencephalon
downregulation of cell proliferation in midbrain
negative regulation of cell proliferation in mesencephalon
inhibition of cell proliferation in mesencephalon
inhibition of cell proliferation in midbrain
down regulation of mesencepahalic cell proliferation
down-regulation of mesencepahalic cell proliferation
downregulation of mesencepahalic cell proliferation
inhibition of mesencepahalic cell proliferation
negative regulation of mesencepahalic cell proliferation
negative regulation of cell proliferation in midbrain
Any process that activates or increases the frequency, rate or extent of cell proliferation in midbrain.
positive regulation of cell proliferation in mesencephalon
up regulation of cell proliferation in mesencephalon
up regulation of cell proliferation in midbrain
up-regulation of cell proliferation in mesencephalon
up-regulation of cell proliferation in midbrain
upregulation of cell proliferation in mesencephalon
upregulation of cell proliferation in midbrain
activation of cell proliferation in mesencephalon
activation of cell proliferation in midbrain
activation of mesencepahalic cell proliferation
positive regulation of mesencepahalic cell proliferation
up regulation of mesencepahalic cell proliferation
up-regulation of mesencepahalic cell proliferation
upregulation of mesencepahalic cell proliferation
positive regulation of cell proliferation in midbrain
The orderly movement of an interneuron from one site to another.
The orderly movement of a sensory neuron from one site to another.
Any process that modulates the frequency, rate or extent of cardiac ventricle formation.
regulation of cardiac ventricle formation
Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle formation.
down regulation of cardiac ventricle formation
down-regulation of cardiac ventricle formation
downregulation of cardiac ventricle formation
inhibition of cardiac ventricle formation
negative regulation of cardiac ventricle formation
Any process that activates or increases the frequency, rate or extent of cardiac ventricle formation.
up regulation of cardiac ventricle formation
up-regulation of cardiac ventricle formation
upregulation of cardiac ventricle formation
activation of cardiac ventricle formation
positive regulation of cardiac ventricle formation
Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization.
down regulation of establishment of protein localisation
down regulation of establishment of protein localization
down-regulation of establishment of protein localisation
down-regulation of establishment of protein localization
downregulation of establishment of protein localisation
downregulation of establishment of protein localization
negative regulation of establishment of protein localisation
negative regulation of protein positioning
negative regulation of protein recruitment
inhibition of establishment of protein localisation
inhibition of establishment of protein localization
negative regulation of establishment of protein localization
Any process that activates or increases the frequency, rate or extent of establishment of protein localization.
positive regulation of establishment of protein localisation
positive regulation of protein positioning
positive regulation of protein recruitment
up regulation of establishment of protein localisation
up regulation of establishment of protein localization
up-regulation of establishment of protein localisation
up-regulation of establishment of protein localization
upregulation of establishment of protein localisation
upregulation of establishment of protein localization
activation of establishment of protein localisation
activation of establishment of protein localization
positive regulation of establishment of protein localization
Any process that modulates the frequency, rate or extent of endothelial cell activation.
regulation of endothelial cell activation
Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell activation.
down regulation of endothelial cell activation
down-regulation of endothelial cell activation
downregulation of endothelial cell activation
inhibition of endothelial cell activation
negative regulation of endothelial cell activation
Any process that activates or increases the frequency, rate or extent of endothelial cell activation.
up regulation of endothelial cell activation
up-regulation of endothelial cell activation
upregulation of endothelial cell activation
activation of endothelial cell activation
positive regulation of endothelial cell activation
Any process that modulates the frequency, rate or extent of membrane lipid metabolic process.
regulation of membrane lipid metabolic process
The process in which carboxylic acid is transported across a membrane.
Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation.
regulation of vascular smooth muscle cell differentiation
regulation of vascular associated smooth muscle cell differentiation
Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation.
down regulation of vascular associated smooth muscle cell differentiation
down regulation of vascular smooth muscle cell differentiation
down-regulation of vascular associated smooth muscle cell differentiation
down-regulation of vascular smooth muscle cell differentiation
downregulation of vascular associated smooth muscle cell differentiation
downregulation of vascular smooth muscle cell differentiation
negative regulation of VSMC differentiation
negative regulation of vascular smooth muscle cell differentiation
inhibition of vascular associated smooth muscle cell differentiation
inhibition of vascular smooth muscle cell differentiation
negative regulation of vascular associated smooth muscle cell differentiation
Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation.
positive regulation of VSMC differentiation
positive regulation of vascular smooth muscle cell differentiation
up regulation of vascular associated smooth muscle cell differentiation
up regulation of vascular smooth muscle cell differentiation
up-regulation of vascular associated smooth muscle cell differentiation
up-regulation of vascular smooth muscle cell differentiation
upregulation of vascular associated smooth muscle cell differentiation
upregulation of vascular smooth muscle cell differentiation
activation of vascular associated smooth muscle cell differentiation
activation of vascular smooth muscle cell differentiation
positive regulation of vascular associated smooth muscle cell differentiation
Any process that modulates the frequency, rate or extent of axo-dendritic protein transport.
regulation of axo-dendritic protein transport
Any process that stops, prevents or reduces the frequency, rate or extent of axo-dendritic protein transport.
down regulation of axo-dendritic protein transport
down-regulation of axo-dendritic protein transport
downregulation of axo-dendritic protein transport
down regulation of axonal protein transport
down-regulation of axonal protein transport
downregulation of axonal protein transport
inhibition of axo-dendritic protein transport
negative regulation of axonal protein transport
negative regulation of axo-dendritic protein transport
Any process that activates or increases the frequency, rate or extent of axo-dendritic protein transport.
up regulation of axo-dendritic protein transport
up-regulation of axo-dendritic protein transport
upregulation of axo-dendritic protein transport
activation of axo-dendritic protein transport
positive regulation of axonal protein transport
up regulation of axonal protein transport
up-regulation of axonal protein transport
upregulation of axonal protein transport
positive regulation of axo-dendritic protein transport
The process that gives rise to the apical ectodermal ridge. This process pertains to the initial formation of a structure from unspecified parts.
Any process that modulates the frequency, rate or extent of apical ectodermal ridge formation.
regulation of apical epidermal ridge formation
regulation of crista ectodermalis apicalis formation
regulation of apical ectodermal ridge formation
Any process that stops, prevents or reduces the frequency, rate or extent of apical ectodermal ridge formation.
down regulation of apical ectodermal ridge formation
down regulation of apical epidermal ridge formation
down-regulation of apical ectodermal ridge formation
down-regulation of apical epidermal ridge formation
downregulation of apical ectodermal ridge formation
downregulation of apical epidermal ridge formation
negative regulation of apical epidermal ridge formation
inhibition of apical ectodermal ridge formation
inhibition of apical epidermal ridge formation
down regulation of crista ectodermalis apicalis formation
down-regulation of crista ectodermalis apicalis formation
downregulation of crista ectodermalis apicalis formation
inhibition of crista ectodermalis apicalis formation
negative regulation of crista ectodermalis apicalis formation
negative regulation of apical ectodermal ridge formation
Any process that activates or increases the frequency, rate or extent of apical ectodermal ridge formation.
positive regulation of apical epidermal ridge formation
up regulation of apical ectodermal ridge formation
up regulation of apical epidermal ridge formation
up-regulation of apical ectodermal ridge formation
up-regulation of apical epidermal ridge formation
upregulation of apical ectodermal ridge formation
upregulation of apical epidermal ridge formation
positive regulation of crista ectodermalis apicalis formation
up regulation of crista ectodermalis apicalis formation
up-regulation of crista ectodermalis apicalis formation
upregulation of crista ectodermalis apicalis formation
positive regulation of apical ectodermal ridge formation
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus.
Any process that modulates the frequency, rate or extent of smooth muscle hypertrophy.
Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle hypertrophy.
down regulation of smooth muscle hypertrophy
down-regulation of smooth muscle hypertrophy
downregulation of smooth muscle hypertrophy
negative regulation of smooth muscle hypertrophy
Any process that activates or increases the frequency, rate or extent of smooth muscle hypertrophy.
up regulation of smooth muscle hypertrophy
up-regulation of smooth muscle hypertrophy
upregulation of smooth muscle hypertrophy
positive regulation of smooth muscle hypertrophy
Any process that modulates the frequency, rate or extent of cardiocyte differentiation.
regulation of cardiac cell differentiation
regulation of heart cell differentiation
regulation of cardiocyte differentiation
Any process that stops, prevents or reduces the frequency, rate or extent of cardiocyte differentiation.
down regulation of cardiac cell differentiation
down regulation of cardiocyte differentiation
down regulation of heart cell differentiation
down-regulation of cardiac cell differentiation
down-regulation of cardiocyte differentiation
down-regulation of heart cell differentiation
downregulation of cardiac cell differentiation
downregulation of cardiocyte differentiation
downregulation of heart cell differentiation
negative regulation of cardiac cell differentiation
negative regulation of heart cell differentiation
inhibition of cardiac cell differentiation
inhibition of cardiocyte differentiation
inhibition of heart cell differentiation
negative regulation of cardiocyte differentiation
Any process that activates or increases the frequency, rate or extent of cardiocyte differentiation.
positive regulation of cardiac cell differentiation
positive regulation of heart cell differentiation
up regulation of cardiac cell differentiation
up regulation of cardiocyte differentiation
up regulation of heart cell differentiation
up-regulation of cardiac cell differentiation
up-regulation of cardiocyte differentiation
up-regulation of heart cell differentiation
upregulation of cardiac cell differentiation
upregulation of cardiocyte differentiation
upregulation of heart cell differentiation
activation of cardiac cell differentiation
activation of cardiocyte differentiation
activation of heart cell differentiation
positive regulation of cardiocyte differentiation
Any process that stops, prevents or reduces the frequency, rate or extent of mitotic chromosome condensation.
negative regulation of mitotic chromosome condensation
The developmental process by which an epicardium is generated and organized.
visceral serous pericardium of heart morphogenesis
visceral serous pericardium proper morphogenesis
pericardium visceral mesothelium morphogenesis
Any process that stops, prevents or reduces the frequency, rate or extent of chromatin organization.
down regulation of chromatin organisation
down regulation of chromatin organization
down regulation of establishment or maintenance of chromatin architecture
down-regulation of chromatin organisation
down-regulation of chromatin organization
down-regulation of establishment or maintenance of chromatin architecture
downregulation of chromatin organisation
downregulation of chromatin organization
downregulation of establishment or maintenance of chromatin architecture
negative regulation of chromatin assembly/disassembly
negative regulation of chromatin organisation
negative regulation of establishment or maintenance of chromatin architecture
inhibition of chromatin assembly or disassembly
inhibition of establishment or maintenance of chromatin architecture
down regulation of chromatin assembly or disassembly
down-regulation of chromatin assembly or disassembly
downregulation of chromatin assembly or disassembly
negative regulation of chromatin assembly or disassembly
negative regulation of chromatin modification
negative regulation of chromatin organization
Any process that activates or increases the frequency, rate or extent of chromatin organization.
positive regulation of chromatin organisation
positive regulation of establishment or maintenance of chromatin architecture
up regulation of establishment or maintenance of chromatin architecture
up-regulation of establishment or maintenance of chromatin architecture
upregulation of chromatin assembly or disassembly
upregulation of establishment or maintenance of chromatin architecture
activation of chromatin assembly or disassembly
activation of establishment or maintenance of chromatin architecture
stimulation of chromatin assembly or disassembly
positive regulation of chromatin assembly or disassembly
positive regulation of chromatin assembly/disassembly
positive regulation of chromatin modification
up regulation of chromatin assembly or disassembly
up-regulation of chromatin assembly or disassembly
positive regulation of chromatin organization
Any process that modulates the frequency, rate or extent of epithelial tube formation.
An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay).
Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation.
down regulation of epithelial tube formation
down-regulation of epithelial tube formation
downregulation of epithelial tube formation
negative regulation of epithelial tube formation
Any process that activates or increases the frequency, rate or extent of epithelial tube formation.
up regulation of epithelial tube formation
up-regulation of epithelial tube formation
upregulation of epithelial tube formation
positive regulation of epithelial tube formation
Any apoptotic process in a vascular associated smooth muscle cell.
vascular smooth muscle cell apoptotic process
vascular associated smooth muscle cell apoptosis
vascular associated smooth muscle cell apoptotic process
Any process that modulates the frequency, rate or extent of neural crest cell differentiation.
regulation of neural crest cell differentiation
Any process that stops, prevents or reduces the frequency, rate or extent of neural crest cell differentiation.
down regulation of neural crest cell differentiation
down-regulation of neural crest cell differentiation
downregulation of neural crest cell differentiation
inhibition of neural crest cell differentiation
negative regulation of neural crest cell differentiation
Any process that activates or increases the frequency, rate or extent of neural crest cell differentiation.
up regulation of neural crest cell differentiation
up-regulation of neural crest cell differentiation
upregulation of neural crest cell differentiation
activation of neural crest cell differentiation
positive regulation of neural crest cell differentiation
Any process that modulates the frequency, rate or extent of cardiac myofibril assembly.
regulation of cardiac myofibril development
regulation of cardiac myofibril morphogenesis
regulation of cardiac myofibril assembly
Any process that stops, prevents or reduces the frequency, rate or extent of cardiac myofibril assembly.
down regulation of cardiac myofibril assembly
down regulation of cardiac myofibril development
down regulation of cardiac myofibril morphogenesis
down-regulation of cardiac myofibril assembly
down-regulation of cardiac myofibril development
down-regulation of cardiac myofibril morphogenesis
downregulation of cardiac myofibril assembly
downregulation of cardiac myofibril development
downregulation of cardiac myofibril morphogenesis
negative regulation of cardiac myofibril development
negative regulation of cardiac myofibril morphogenesis
inhibition of cardiac myofibril assembly
inhibition of cardiac myofibril development
inhibition of cardiac myofibril morphogenesis
down regulation of heart myofibril assembly
down-regulation of heart myofibril assembly
downregulation of heart myofibril assembly
negative regulation of heart myofibril assembly
negative regulation of cardiac myofibril assembly
Any process that activates or increases the frequency, rate or extent of cardiac myofibril assembly.
positive regulation of cardiac myofibril development
positive regulation of cardiac myofibril morphogenesis
up regulation of cardiac myofibril assembly
up regulation of cardiac myofibril development
up regulation of cardiac myofibril morphogenesis
up-regulation of cardiac myofibril assembly
up-regulation of cardiac myofibril development
up-regulation of cardiac myofibril morphogenesis
upregulation of cardiac myofibril assembly
upregulation of cardiac myofibril development
upregulation of cardiac myofibril morphogenesis
activation of cardiac myofibril assembly
activation of cardiac myofibril development
activation of cardiac myofibril morphogenesis
positive regulation of heart myofibril assembly
up regulation of heart myofibril assembly
up-regulation of heart myofibril assembly
upregulation of heart myofibril assembly
positive regulation of cardiac myofibril assembly
Any process that modulates the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis.
regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
Any process that stops, prevents or reduces the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis.
down regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
down-regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
downregulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
inhibition of cardiac neural crest cell migration involved in outflow tract morphogenesis
negative regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
Any process that activates or increases the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis.
up regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
up-regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
upregulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
activation of cardiac neural crest cell migration involved in outflow tract morphogenesis
positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
Any cell proliferation that is involved in endocardial cushion morphogenesis.
cell proliferation involved in endocardial cushion morphogenesis
The orderly movement of a mesenchymal stem cell from one site to another.
Any process that modulates the frequency, rate or extent of mesenchymal stem cell migration.
regulation of mesenchymal stem cell migration
Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell migration.
down regulation of mesenchymal stem cell migration
down-regulation of mesenchymal stem cell migration
downregulation of mesenchymal stem cell migration
inhibition of mesenchymal stem cell migration
negative regulation of mesenchymal stem cell migration
Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell migration.
up regulation of mesenchymal stem cell migration
up-regulation of mesenchymal stem cell migration
upregulation of mesenchymal stem cell migration
activation of mesenchymal stem cell migration
positive regulation of mesenchymal stem cell migration
Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium.
regulation of morphogenesis of an epithelium
Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium.
down regulation of epithelium morphogenesis
down regulation of morphogenesis of an epithelium
down-regulation of epithelium morphogenesis
down-regulation of morphogenesis of an epithelium
downregulation of epithelium morphogenesis
downregulation of morphogenesis of an epithelium
negative regulation of epithelium morphogenesis
inhibition of morphogenesis of an epithelium
negative regulation of morphogenesis of an epithelium
Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium.
positive regulation of epithelium morphogenesis
up regulation of epithelium morphogenesis
up regulation of morphogenesis of an epithelium
up-regulation of epithelium morphogenesis
up-regulation of morphogenesis of an epithelium
upregulation of epithelium morphogenesis
upregulation of morphogenesis of an epithelium
activation of morphogenesis of an epithelium
positive regulation of morphogenesis of an epithelium
The aggregation, arrangement and bonding together of a set of components to form a ciliary transition zone.
A process in which a protein is transported to, or maintained in, a location within a presynapse.
Any process that modulates the frequency, rate or extent of protein localization to presynapse.
regulation of protein localisation in presynapse
regulation of protein localisation to presynapse
regulation of protein localization in presynapse
regulation of recruitment of presynaptic proteins
regulation of protein localization to presynapse
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to presynapse.
down regulation of protein localisation in presynapse
down regulation of protein localisation to presynapse
down regulation of protein localization in presynapse
down regulation of protein localization to presynapse
down regulation of recruitment of presynaptic proteins
down-regulation of protein localisation in presynapse
down-regulation of protein localisation to presynapse
down-regulation of protein localization in presynapse
down-regulation of protein localization to presynapse
down-regulation of recruitment of presynaptic proteins
downregulation of protein localisation in presynapse
downregulation of protein localisation to presynapse
downregulation of protein localization in presynapse
downregulation of protein localization to presynapse
downregulation of recruitment of presynaptic proteins
negative regulation of protein localisation in presynapse
negative regulation of protein localisation to presynapse
negative regulation of protein localization in presynapse
negative regulation of recruitment of presynaptic proteins
inhibition of protein localisation in presynapse
inhibition of protein localisation to presynapse
inhibition of protein localization in presynapse
inhibition of protein localization to presynapse
inhibition of recruitment of presynaptic proteins
negative regulation of protein localization to presynapse
Any process that activates or increases the frequency, rate or extent of protein localization to presynapse.
positive regulation of protein localisation in presynapse
positive regulation of protein localisation to presynapse
positive regulation of protein localization in presynapse
positive regulation of recruitment of presynaptic proteins
up regulation of protein localisation in presynapse
up regulation of protein localisation to presynapse
up regulation of protein localization in presynapse
up regulation of protein localization to presynapse
up regulation of recruitment of presynaptic proteins
up-regulation of protein localisation in presynapse
up-regulation of protein localisation to presynapse
up-regulation of protein localization in presynapse
up-regulation of protein localization to presynapse
up-regulation of recruitment of presynaptic proteins
upregulation of protein localisation in presynapse
upregulation of protein localisation to presynapse
upregulation of protein localization in presynapse
upregulation of protein localization to presynapse
upregulation of recruitment of presynaptic proteins
activation of protein localisation in presynapse
activation of protein localisation to presynapse
activation of protein localization in presynapse
activation of protein localization to presynapse
activation of recruitment of presynaptic proteins
positive regulation of protein localization to presynapse
Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide.
regulation of neuropeptide-mediated retrograde trans-synaptic signaling
regulation of retrograde trans-synaptic signaling by neuropeptide
Any process that stops, prevents or reduces the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide.
down regulation of retrograde trans-synaptic signaling by neuropeptide
down-regulation of retrograde trans-synaptic signaling by neuropeptide
downregulation of retrograde trans-synaptic signaling by neuropeptide
inhibition of retrograde trans-synaptic signaling by neuropeptide
inhibition of neuropeptide-mediated retrograde trans-synaptic signaling
negative regulation of neuropeptide-mediated retrograde trans-synaptic signaling
negative regulation of retrograde trans-synaptic signaling by neuropeptide
Any process that activates or increases the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide.
up regulation of retrograde trans-synaptic signaling by neuropeptide
up-regulation of retrograde trans-synaptic signaling by neuropeptide
upregulation of retrograde trans-synaptic signaling by neuropeptide
activation of retrograde trans-synaptic signaling by neuropeptide
positive regulation of neuropeptide-mediated retrograde trans-synaptic signaling
positive regulation of retrograde trans-synaptic signaling by neuropeptide
Any process that modulates the frequency, rate or extent of myeloid progenitor cell differentiation.
regulation of myeloid progenitor cell differentiation
Any process that stops, prevents or reduces the frequency, rate or extent of myeloid progenitor cell differentiation.
down regulation of myeloid progenitor cell differentiation
down-regulation of myeloid progenitor cell differentiation
downregulation of myeloid progenitor cell differentiation
inhibition of myeloid progenitor cell differentiation
negative regulation of myeloid progenitor cell differentiation
Any process that activates or increases the frequency, rate or extent of myeloid progenitor cell differentiation.
up regulation of myeloid progenitor cell differentiation
up-regulation of myeloid progenitor cell differentiation
upregulation of myeloid progenitor cell differentiation
activation of myeloid progenitor cell differentiation
positive regulation of myeloid progenitor cell differentiation
Any process that modulates the frequency, rate or extent of lymphoid progenitor cell differentiation.
regulation of lymphoid progenitor cell differentiation
Any process that stops, prevents or reduces the frequency, rate or extent of lymphoid progenitor cell differentiation.
down regulation of lymphoid progenitor cell differentiation
down-regulation of lymphoid progenitor cell differentiation
downregulation of lymphoid progenitor cell differentiation
inhibition of lymphoid progenitor cell differentiation
negative regulation of lymphoid progenitor cell differentiation
Any process that activates or increases the frequency, rate or extent of lymphoid progenitor cell differentiation.
up regulation of lymphoid progenitor cell differentiation
up-regulation of lymphoid progenitor cell differentiation
upregulation of lymphoid progenitor cell differentiation
activation of lymphoid progenitor cell differentiation
positive regulation of lymphoid progenitor cell differentiation
Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process.
regulation of vascular smooth muscle cell apoptotic process
regulation of vascular associated smooth muscle cell apoptosis
regulation of vascular smooth muscle cell apoptosis
regulation of vascular associated smooth muscle cell apoptotic process
Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process.
down regulation of VSMC apoptotic process
down regulation of vascular associated smooth muscle cell apoptotic process
down regulation of vascular smooth muscle cell apoptotic process
down-regulation of VSMC apoptotic process
down-regulation of vascular associated smooth muscle cell apoptotic process
down-regulation of vascular smooth muscle cell apoptotic process
downregulation of VSMC apoptotic process
downregulation of vascular associated smooth muscle cell apoptotic process
downregulation of vascular smooth muscle cell apoptotic process
negative regulation of VSMC apoptotic process
negative regulation of vascular smooth muscle cell apoptotic process
down regulation of vascular associated smooth muscle cell apoptosis
down regulation of vascular smooth muscle cell apoptosis
down-regulation of vascular associated smooth muscle cell apoptosis
down-regulation of vascular smooth muscle cell apoptosis
downregulation of vascular associated smooth muscle cell apoptosis
downregulation of vascular smooth muscle cell apoptosis
inhibition of vascular associated smooth muscle cell apoptosis
inhibition of vascular associated smooth muscle cell apoptotic process
inhibition of vascular smooth muscle cell apoptosis
inhibition of vascular smooth muscle cell apoptotic process
negative regulation of vascular associated smooth muscle cell apoptosis
negative regulation of vascular smooth muscle cell apoptosis
negative regulation of vascular associated smooth muscle cell apoptotic process
Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process.
positive regulation of VSMC apoptotic process
positive regulation of vascular smooth muscle cell apoptotic process
up regulation of vascular associated smooth muscle cell apoptotic process
up regulation of vascular smooth muscle cell apoptotic process
up-regulation of vascular associated smooth muscle cell apoptotic process
up-regulation of vascular smooth muscle cell apoptotic process
upregulation of vascular associated smooth muscle cell apoptotic process
upregulation of vascular smooth muscle cell apoptotic process
activation of vascular associated smooth muscle cell apoptosis
activation of vascular associated smooth muscle cell apoptotic process
activation of vascular smooth muscle cell apoptosis
activation of vascular smooth muscle cell apoptotic process
positive regulation of vascular associated smooth muscle cell apoptosis
positive regulation of vascular smooth muscle cell apoptosis
up regulation of vascular associated smooth muscle cell apoptosis
up regulation of vascular smooth muscle cell apoptosis
up-regulation of vascular associated smooth muscle cell apoptosis
up-regulation of vascular smooth muscle cell apoptosis
upregulation of vascular associated smooth muscle cell apoptosis
upregulation of vascular smooth muscle cell apoptosis
positive regulation of vascular associated smooth muscle cell apoptotic process
Any process that modulates the frequency, rate or extent of protein localization to membrane.
regulation of protein localisation in membrane
regulation of protein localization in membrane
regulation of protein localization to membrane
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to membrane.
down regulation of protein localisation in membrane
down regulation of protein localization in membrane
down regulation of protein localization to membrane
down-regulation of protein localisation in membrane
down-regulation of protein localization in membrane
down-regulation of protein localization to membrane
downregulation of protein localisation in membrane
downregulation of protein localization in membrane
downregulation of protein localization to membrane
negative regulation of protein localisation in membrane
negative regulation of protein localization in membrane
inhibition of protein localisation in membrane
inhibition of protein localization in membrane
inhibition of protein localization to membrane
negative regulation of protein localization to membrane
Any process that activates or increases the frequency, rate or extent of protein localization to membrane.
positive regulation of protein localisation in membrane
positive regulation of protein localization in membrane
up regulation of protein localisation in membrane
up regulation of protein localization in membrane
up regulation of protein localization to membrane
up-regulation of protein localisation in membrane
up-regulation of protein localization in membrane
up-regulation of protein localization to membrane
upregulation of protein localisation in membrane
upregulation of protein localization in membrane
upregulation of protein localization to membrane
activation of protein localisation in membrane
activation of protein localization in membrane
activation of protein localization to membrane
positive regulation of protein localization to membrane
Any process that modulates the frequency, rate or extent of motor neuron migration.
Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron migration.
down regulation of motor neuron migration
down-regulation of motor neuron migration
downregulation of motor neuron migration
negative regulation of motor neuron migration
Any process that activates or increases the frequency, rate or extent of motor neuron migration.
positive regulation of motor neuron migration
Any process that activates or increases the frequency, rate or extent of branching morphogenesis of a nerve.
up regulation of branching morphogenesis of a nerve
up-regulation of branching morphogenesis of a nerve
upregulation of branching morphogenesis of a nerve
activation of branching morphogenesis of a nerve
positive regulation of branching morphogenesis of a nerve
Any process that modulates the frequency, rate or extent of motile cilium assembly.
regulation of motile primary cilia assembly
regulation of motile primary cilia formation
regulation of motile primary cilium assembly
regulation of motile primary cilium formation
Any process that stops, prevents or reduces the frequency, rate or extent of motile cilium assembly.
inhibition of motile primary cilia assembly
inhibition of motile primary cilia formation
inhibition of motile primary cilium assembly
inhibition of motile primary cilium formation
down regulation of motile primary cilia assembly
down regulation of motile primary cilia formation
down regulation of motile primary cilium assembly
down regulation of motile primary cilium formation
down regulation of nodal cilium assembly
down regulation of nodal cilium formation
down-regulation of motile primary cilia assembly
down-regulation of motile primary cilia formation
down-regulation of motile primary cilium assembly
down-regulation of motile primary cilium formation
down-regulation of nodal cilium assembly
down-regulation of nodal cilium formation
downregulation of motile primary cilia assembly
downregulation of motile primary cilia formation
downregulation of motile primary cilium assembly
downregulation of motile primary cilium formation
downregulation of nodal cilium formation
negative regulation of motile primary cilia assembly
negative regulation of motile primary cilia formation
negative regulation of motile primary cilium assembly
negative regulation of motile primary cilium formation
negative regulation of nodal cilium assembly
negative regulation of nodal cilium formation
negative regulation of motile cilium assembly
Any process that activates or increases the frequency, rate or extent of motile cilium assembly.
activation of motile primary cilia assembly
activation of motile primary cilia formation
activation of motile primary cilium assembly
activation of motile primary cilium formation
positive regulation of motile primary cilia assembly
positive regulation of motile primary cilia formation
positive regulation of motile primary cilium assembly
positive regulation of motile primary cilium formation
positive regulation of nodal cilium assembly
positive regulation of nodal cilium formation
up regulation of motile primary cilia assembly
up regulation of motile primary cilia formation
up regulation of motile primary cilium assembly
up regulation of motile primary cilium formation
up-regulation of motile primary cilia assembly
up-regulation of motile primary cilia formation
up-regulation of motile primary cilium assembly
up-regulation of motile primary cilium formation
upregulation of motile primary cilia assembly
upregulation of motile primary cilia formation
upregulation of motile primary cilium assembly
upregulation of motile primary cilium formation
positive regulation of motile cilium assembly
A process in which a protein is transported to, or maintained in, a location within a microtubule organizing center.
protein localisation in microtubule organizing center
protein localisation to microtubule organizing center
protein localization in microtubule organizing center
protein localization to microtubule organizing center
Any process that activates or increases the frequency, rate or extent of fertilization.
Any process that modulates the frequency, rate or extent of blood vessel branching.
regulation of branching involved in blood vessel morphogenesis
Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel branching.
down regulation of branching involved in blood vessel morphogenesis
down regulation of patterning of blood vessels
down-regulation of branching involved in blood vessel morphogenesis
down-regulation of patterning of blood vessels
downregulation of branching involved in blood vessel morphogenesis
downregulation of patterning of blood vessels
negative regulation of branching involved in blood vessel morphogenesis
inhibition of branching involved in blood vessel morphogenesis
inhibition of patterning of blood vessels
negative regulation of blood vessel branching
Any process that activates or increases the frequency, rate or extent of blood vessel branching.
positive regulation of branching involved in blood vessel morphogenesis
up regulation of branching involved in blood vessel morphogenesis
up regulation of patterning of blood vessels
up-regulation of branching involved in blood vessel morphogenesis
up-regulation of patterning of blood vessels
upregulation of branching involved in blood vessel morphogenesis
upregulation of patterning of blood vessels
activation of branching involved in blood vessel morphogenesis
activation of patterning of blood vessels
positive regulation of blood vessel branching
Any process that modulates the frequency, rate or extent of mitotic nuclear envelope disassembly.
regulation of mitotic nuclear envelope breakdown
regulation of mitotic nuclear envelope catabolism
regulation of mitotic nuclear envelope degradation
regulation of mitotic nuclear envelope disassembly
Any process that stops, prevents or reduces the frequency, rate or extent of mitotic nuclear envelope disassembly.
down regulation of mitotic nuclear envelope breakdown
down regulation of mitotic nuclear envelope catabolism
down regulation of mitotic nuclear envelope degradation
down regulation of mitotic nuclear envelope disassembly
down-regulation of mitotic nuclear envelope breakdown
down-regulation of mitotic nuclear envelope catabolism
down-regulation of mitotic nuclear envelope degradation
down-regulation of mitotic nuclear envelope disassembly
downregulation of mitotic nuclear envelope breakdown
downregulation of mitotic nuclear envelope catabolism
downregulation of mitotic nuclear envelope degradation
downregulation of mitotic nuclear envelope disassembly
negative regulation of mitotic nuclear envelope breakdown
negative regulation of mitotic nuclear envelope catabolism
negative regulation of mitotic nuclear envelope degradation
inhibition of mitotic nuclear envelope breakdown
inhibition of mitotic nuclear envelope catabolism
inhibition of mitotic nuclear envelope degradation
inhibition of mitotic nuclear envelope disassembly
negative regulation of mitotic nuclear envelope disassembly
Any process that activates or increases the frequency, rate or extent of mitotic nuclear envelope disassembly.
positive regulation of mitotic nuclear envelope breakdown
positive regulation of mitotic nuclear envelope catabolism
positive regulation of mitotic nuclear envelope degradation
up regulation of mitotic nuclear envelope breakdown
up regulation of mitotic nuclear envelope catabolism
up regulation of mitotic nuclear envelope degradation
up regulation of mitotic nuclear envelope disassembly
up-regulation of mitotic nuclear envelope breakdown
up-regulation of mitotic nuclear envelope catabolism
up-regulation of mitotic nuclear envelope degradation
up-regulation of mitotic nuclear envelope disassembly
upregulation of mitotic nuclear envelope breakdown
upregulation of mitotic nuclear envelope catabolism
upregulation of mitotic nuclear envelope degradation
upregulation of mitotic nuclear envelope disassembly
activation of mitotic nuclear envelope breakdown
activation of mitotic nuclear envelope catabolism
activation of mitotic nuclear envelope degradation
activation of mitotic nuclear envelope disassembly
positive regulation of mitotic nuclear envelope disassembly
Any process that modulates the frequency, rate or extent of vascular endothelial cell proliferation.
regulation of vascular endothelial cell proliferation
Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial cell proliferation.
down regulation of vascular endothelial cell proliferation
down-regulation of vascular endothelial cell proliferation
downregulation of vascular endothelial cell proliferation
inhibition of vascular endothelial cell proliferation
negative regulation of vascular endothelial cell proliferation
Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation.
up regulation of vascular endothelial cell proliferation
up-regulation of vascular endothelial cell proliferation
upregulation of vascular endothelial cell proliferation
activation of vascular endothelial cell proliferation
positive regulation of vascular endothelial cell proliferation
Any process that modulates the frequency, rate or extent of presynapse assembly.
regulation of presynaptic terminal assembly
Any process that stops, prevents or reduces the frequency, rate or extent of presynapse assembly.
down regulation of presynapse biogenesis
down regulation of presynaptic terminal assembly
down-regulation of presynapse biogenesis
down-regulation of presynaptic terminal assembly
downregulation of presynaptic terminal assembly
negative regulation of presynapse biogenesis
negative regulation of presynaptic terminal assembly
inhibition of presynaptic terminal assembly
negative regulation of presynapse assembly
Any process that activates or increases the frequency, rate or extent of presynapse assembly.
positive regulation of presynapse biogenesis
positive regulation of presynaptic terminal assembly
up regulation of presynaptic terminal assembly
up-regulation of presynaptic terminal assembly
upregulation of presynaptic terminal assembly
activation of presynaptic terminal assembly
positive regulation of presynapse assembly
Any process that modulates the frequency, rate or extent of serotonin biosynthetic process.
regulation of serotonin biosynthetic process
Any process that stops, prevents or reduces the frequency, rate or extent of serotonin biosynthetic process.
down regulation of serotonin biosynthesis
down regulation of serotonin biosynthetic process
down-regulation of serotonin biosynthesis
down-regulation of serotonin biosynthetic process
downregulation of serotonin biosynthesis
downregulation of serotonin biosynthetic process
negative regulation of serotonin anabolism
negative regulation of serotonin biosynthesis
negative regulation of serotonin formation
negative regulation of serotonin synthesis
inhibition of serotonin biosynthetic process
negative regulation of serotonin biosynthetic process
Any process that activates or increases the frequency, rate or extent of serotonin biosynthetic process.
positive regulation of serotonin anabolism
positive regulation of serotonin biosynthesis
positive regulation of serotonin formation
positive regulation of serotonin synthesis
up regulation of serotonin biosynthetic process
up-regulation of serotonin biosynthetic process
upregulation of serotonin biosynthetic process
activation of serotonin biosynthetic process
positive regulation of serotonin biosynthetic process
Any process that modulates the frequency, rate or extent of protein localization to chromatin.
regulation of protein localisation to chromatin
regulation of protein localization to chromatin
Any process that modulates the frequency, rate or extent of artery morphogenesis.
Any process that stops, prevents or reduces the frequency, rate or extent of artery morphogenesis.
down regulation of arterial morphogenesis
down-regulation of arterial morphogenesis
downregulation of arterial morphogenesis
negative regulation of arterial morphogenesis
negative regulation of artery morphogenesis
Any process that activates or increases the frequency, rate or extent of artery morphogenesis.
positive regulation of arterial morphogenesis
positive regulation of artery morphogenesis
The disaggregation of a nucleus into its constituent components.
Any microtubule bundle that is part of a cytoplasm.
A process in which a protein is transported to, or maintained in, a location within a cytoplasmic microtubule.
protein localisation to cytoplasmic microtubule
protein localization to cytoplasmic microtubule
Any process that modulates the frequency, rate or extent of mesodermal cell differentiation.
regulation of mesoderm cell differentiation
regulation of mesodermal cell differentiation
Any process that stops, prevents or reduces the frequency, rate or extent of mesodermal cell differentiation.
down regulation of mesoderm cell differentiation
down regulation of mesodermal cell differentiation
down-regulation of mesoderm cell differentiation
down-regulation of mesodermal cell differentiation
downregulation of mesoderm cell differentiation
downregulation of mesodermal cell differentiation
negative regulation of mesoderm cell differentiation
inhibition of mesoderm cell differentiation
inhibition of mesodermal cell differentiation
negative regulation of mesodermal cell differentiation
Any process that activates or increases the frequency, rate or extent of mesodermal cell differentiation.
positive regulation of mesoderm cell differentiation
up regulation of mesoderm cell differentiation
up regulation of mesodermal cell differentiation
up-regulation of mesoderm cell differentiation
up-regulation of mesodermal cell differentiation
upregulation of mesoderm cell differentiation
upregulation of mesodermal cell differentiation
activation of mesoderm cell differentiation
activation of mesodermal cell differentiation
positive regulation of mesodermal cell differentiation
Any process that modulates the frequency, rate or extent of synapse pruning.
Any process that stops, prevents or reduces the frequency, rate or extent of synapse pruning.
Any process that activates or increases the frequency, rate or extent of synapse pruning.
Any process that stops, prevents or reduces the frequency, rate or extent of synapse organization.
negative regulation of synapse development
negative regulation of synapse organisation
down regulation of synapse morphogenesis
down regulation of synapse organization and biogenesis
down-regulation of synapse morphogenesis
down-regulation of synapse organization and biogenesis
downregulation of synapse organization and biogenesis
inhibition of synapse organization and biogenesis
negative regulation of synapse morphogenesis
negative regulation of synapse organization and biogenesis
negative regulation of synapse organization
Any process that activates or increases the frequency, rate or extent of chromosome condensation.
positive regulation of eukaryotic chromosome condensation
positive regulation of nuclear chromosome condensation
up regulation of chromosome condensation
up regulation of eukaryotic chromosome condensation
up regulation of nuclear chromosome condensation
up-regulation of chromosome condensation
up-regulation of eukaryotic chromosome condensation
up-regulation of nuclear chromosome condensation
upregulation of eukaryotic chromosome condensation
upregulation of nuclear chromosome condensation
activation of eukaryotic chromosome condensation
activation of nuclear chromosome condensation
positive regulation of chromosome condensation
Any process that stops, prevents or reduces the frequency, rate or extent of microtubule nucleation.
down regulation of microtubule nucleation
down-regulation of microtubule nucleation
downregulation of microtubule nucleation
negative regulation of microtubule nucleation
Any process that modulates the frequency, rate or extent of protein localization to cell leading edge.
regulation of protein localisation in cell leading edge
regulation of protein localisation to cell leading edge
regulation of protein localization in cell leading edge
regulation of protein localization to cell leading edge
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell leading edge.
down regulation of protein localisation in cell leading edge
down regulation of protein localisation to cell leading edge
down regulation of protein localization in cell leading edge
down regulation of protein localization to cell leading edge
down-regulation of protein localisation in cell leading edge
down-regulation of protein localisation to cell leading edge
down-regulation of protein localization in cell leading edge
down-regulation of protein localization to cell leading edge
downregulation of protein localisation in cell leading edge
downregulation of protein localisation to cell leading edge
downregulation of protein localization in cell leading edge
downregulation of protein localization to cell leading edge
negative regulation of protein localisation in cell leading edge
negative regulation of protein localisation to cell leading edge
negative regulation of protein localization in cell leading edge
inhibition of protein localisation in cell leading edge
inhibition of protein localisation to cell leading edge
inhibition of protein localization in cell leading edge
inhibition of protein localization to cell leading edge
negative regulation of protein localization to cell leading edge
Any process that activates or increases the frequency, rate or extent of protein localization to cell leading edge.
positive regulation of protein localisation in cell leading edge
positive regulation of protein localisation to cell leading edge
positive regulation of protein localization in cell leading edge
up regulation of protein localisation in cell leading edge
up regulation of protein localisation to cell leading edge
up regulation of protein localization in cell leading edge
up regulation of protein localization to cell leading edge
up-regulation of protein localisation in cell leading edge
up-regulation of protein localisation to cell leading edge
up-regulation of protein localization in cell leading edge
up-regulation of protein localization to cell leading edge
upregulation of protein localisation in cell leading edge
upregulation of protein localisation to cell leading edge
upregulation of protein localization in cell leading edge
upregulation of protein localization to cell leading edge
activation of protein localisation in cell leading edge
activation of protein localisation to cell leading edge
activation of protein localization in cell leading edge
activation of protein localization to cell leading edge
positive regulation of protein localization to cell leading edge
Any process that modulates the frequency, rate or extent of oogenesis.
Any process that stops, prevents or reduces the frequency, rate or extent of oogenesis.
Any process that activates or increases the frequency, rate or extent of oogenesis.
Any process that modulates the frequency, rate or extent of smooth muscle tissue development.
regulation of smooth muscle tissue development
Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle tissue development.
down regulation of smooth muscle tissue development
down-regulation of smooth muscle tissue development
downregulation of smooth muscle tissue development
inhibition of smooth muscle tissue development
negative regulation of smooth muscle tissue development
Any process that activates or increases the frequency, rate or extent of smooth muscle tissue development.
up regulation of smooth muscle tissue development
up-regulation of smooth muscle tissue development
upregulation of smooth muscle tissue development
activation of smooth muscle tissue development
positive regulation of smooth muscle tissue development
Any process that modulates the frequency, rate or extent of mesoderm formation.
Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation.
negative regulation of mesoderm formation
Any process that activates or increases the frequency, rate or extent of mesoderm formation.
positive regulation of mesoderm formation
Any process that modulates the frequency, rate or extent of acetylcholine biosynthetic process.
regulation of acetylcholine biosynthesis
regulation of acetylcholine biosynthetic process
Any process that stops, prevents or reduces the frequency, rate or extent of acetylcholine biosynthetic process.
down regulation of acetylcholine anabolism
down regulation of acetylcholine biosynthesis
down regulation of acetylcholine biosynthetic process
down regulation of acetylcholine formation
down regulation of acetylcholine synthesis
down-regulation of acetylcholine anabolism
down-regulation of acetylcholine biosynthesis
down-regulation of acetylcholine biosynthetic process
down-regulation of acetylcholine formation
down-regulation of acetylcholine synthesis
downregulation of acetylcholine anabolism
downregulation of acetylcholine biosynthesis
downregulation of acetylcholine biosynthetic process
downregulation of acetylcholine formation
downregulation of acetylcholine synthesis
negative regulation of acetylcholine anabolism
negative regulation of acetylcholine biosynthesis
negative regulation of acetylcholine formation
negative regulation of acetylcholine synthesis
inhibition of acetylcholine biosynthesis
inhibition of acetylcholine biosynthetic process
negative regulation of acetylcholine biosynthetic process
Any process that activates or increases the frequency, rate or extent of acetylcholine biosynthetic process.
positive regulation of acetylcholine anabolism
positive regulation of acetylcholine biosynthesis
positive regulation of acetylcholine formation
positive regulation of acetylcholine synthesis
up regulation of acetylcholine anabolism
up regulation of acetylcholine biosynthesis
up regulation of acetylcholine biosynthetic process
up regulation of acetylcholine formation
up regulation of acetylcholine synthesis
up-regulation of acetylcholine anabolism
up-regulation of acetylcholine biosynthesis
up-regulation of acetylcholine biosynthetic process
up-regulation of acetylcholine formation
up-regulation of acetylcholine synthesis
upregulation of acetylcholine biosynthesis
upregulation of acetylcholine biosynthetic process
activation of acetylcholine biosynthesis
activation of acetylcholine biosynthetic process
positive regulation of acetylcholine biosynthetic process
Any process that modulates the frequency, rate or extent of germ cell proliferation.
Any process that stops, prevents or reduces the frequency, rate or extent of germ cell proliferation.
down regulation of germ cell proliferation
down-regulation of germ cell proliferation
downregulation of germ cell proliferation
negative regulation of germ cell proliferation
Any process that activates or increases the frequency, rate or extent of germ cell proliferation.
up regulation of germ cell proliferation
up-regulation of germ cell proliferation
positive regulation of germ cell proliferation
Any process that modulates the frequency, rate or extent of gonad development.
Any process that stops, prevents or reduces the frequency, rate or extent of gonad development.
negative regulation of gonad development
Any process that activates or increases the frequency, rate or extent of gonad development.
positive regulation of gonad development
Any process that modulates the frequency, rate or extent of lipid localization.
Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization.
negative regulation of lipid localisation
negative regulation of lipid localization
Any process that activates or increases the frequency, rate or extent of lipid localization.
positive regulation of lipid localisation
positive regulation of lipid localization
Any process that stops, prevents or reduces the frequency, rate or extent of endothelial tube morphogenesis.
down regulation of endothelial tube morphogenesis
down-regulation of endothelial tube morphogenesis
downregulation of endothelial tube morphogenesis
inhibition of endothelial tube morphogenesis
negative regulation of endothelial tube morphogenesis
Any process that activates or increases the frequency, rate or extent of endothelial tube morphogenesis.
up regulation of endothelial tube morphogenesis
up-regulation of endothelial tube morphogenesis
upregulation of endothelial tube morphogenesis
activation of endothelial tube morphogenesis
positive regulation of endothelial tube morphogenesis
Any apoptotic process in a retinal cell.
induction of retinal programmed cell death
Any apoptotic process in a compound eye retinal cell.
compound eye retinal cell apoptotic process
The directed movement of substances in neuronal dense core vesicles along axonal microtubules towards the presynapse.
anterograde dense core granule trafficking
anterograde dense core granule transport
anterograde neuronal dense core vesicle transport
The directed movement of neuronal dense core vesicles along axonal microtubules towards the cell body.
retrograde dense core granule trafficking
retrograde neuronal dense core vesicle transport
The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.
extracellular vesicular exosome secretion
multi-vesicular body fusion with plasma membrane
A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin.
Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis.
Any process that modulates the frequency, rate or extent of cytoplasmic translational termination.
regulation of cytoplasmic translational termination
The flow of blood through the gastric mucosa of an animal, enabling the transport of nutrients and the removal of waste products.
A process in which a protein is transported to, or maintained in, the cell periphery.
Any process in which the vacuole is transported to, and/or maintained in, a specific location within the cell.
The multiplication or reproduction of acinar cells, resulting in the expansion of a cell population. An acinar cell is a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini (singular acinus).
The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels.
vascular smooth muscle cell proliferation
vascular associated smooth muscle cell proliferation
A macromolecular complex that contains both RNA and protein molecules.
Any process that modulates the frequency, rate or extent of multicellular organismal development.
regulation of multicellular organismal development
Any process that modulates the frequency, rate or extent of animal organ morphogenesis.
regulation of histogenesis and organogenesis
regulation of animal organ morphogenesis
Any process that modulates the frequency, rate or extent of stem cell division.
Any process that modulates the frequency, rate or extent of defense response to insect.
regulation of physiological defense response to insect
regulation of defense response to insect
Any process that modulates the frequency, rate or extent of leukocyte apoptotic process.
regulation of leukocyte apoptotic process
Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process.
negative regulation of leukocyte apoptosis
negative regulation of leukocyte apoptotic process
Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process.
positive regulation of leukocyte apoptosis
positive regulation of leukocyte apoptotic process
Any process that modulates the frequency, rate or extent of establishment of cell polarity.
regulation of bud site selection/establishment of cell polarity
regulation of establishment of cell polarity
Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis.
regulation of cell proliferation involved in heart morphogenesis
Any process that stops, prevents, or reduces the frequency, rate or extent of cell proliferation involved in heart morphogenesis.
negative regulation of cell proliferation involved in heart morphogenesis
Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis.
positive regulation of cell proliferation involved in heart morphogenesis
Any process that modulates the frequency, rate or extent of cell motility.
Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility.
negative regulation of movement of a cell
Any process that activates or increases the frequency, rate or extent of cell motility.
positive regulation of movement of a cell
Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility.
positive regulation of ciliary cell motility
positive regulation of cilium-dependent cell motility
Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite development.
negative regulation of dendrite development
Any process that modulates the frequency, rate or extent of branching morphogenesis of a nerve.
regulation of branching morphogenesis of a nerve
Any process that stops, prevents, or reduces the frequency, rate or extent of branching morphogenesis of a nerve.
negative regulation of branching morphogenesis of a nerve
Any process that modulates the frequency, rate or extent of neural precursor cell proliferation.
regulation of neural precursor cell proliferation
Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation.
negative regulation of neural precursor cell proliferation
Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation.
positive regulation of neural precursor cell proliferation
Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis.
negative regulation of blood vessel morphogenesis
Any process that modulates the frequency, rate or extent of female gonad development.
Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development.
negative regulation of ovarian development
negative regulation of ovary development
negative regulation of female gonad development
Any process that activates or increases the frequency, rate or extent of female gonad development.
positive regulation of ovarian development
positive regulation of ovary development
positive regulation of female gonad development
Any process that modulates the frequency, rate or extent of reproductive process.
Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process.
negative regulation of reproductive process
Any process that activates or increases the frequency, rate or extent of reproductive process.
positive regulation of reproductive process
Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity.
negative regulation of establishment and/or maintenance of neuroblast cell polarity
negative regulation of establishment or maintenance of neuroblast polarity
Any process that modulates the frequency, rate or extent of fibroblast apoptotic process.
regulation of fibroblast apoptotic process
Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process.
negative regulation of fibroblast apoptosis
negative regulation of fibroblast apoptotic process
Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process.
positive regulation of fibroblast apoptosis
positive regulation of fibroblast apoptotic process
Any process that modulates the frequency, rate or extent of cellular amino acid biosynthetic process.
regulation of cellular amino acid anabolism
regulation of cellular amino acid biosynthesis
regulation of cellular amino acid biosynthetic process
regulation of cellular amino acid formation
regulation of cellular amino acid synthesis
regulation of amino acid biosynthetic process
Any process that stops, prevents or reduces the frequency, rate or extent of an amino acid biosynthetic process.
negative regulation of amino acid anabolism
negative regulation of amino acid biosynthesis
negative regulation of amino acid formation
negative regulation of amino acid synthesis
negative regulation of cellular amino acid biosynthetic process
negative regulation of amino acid biosynthetic process
Any process that activates or increases the frequency, rate or extent of cellular amino acid biosynthetic process.
positive regulation of amino acid anabolism
positive regulation of amino acid biosynthesis
positive regulation of amino acid formation
positive regulation of amino acid synthesis
positive regulation of cellular amino acid biosynthetic process
positive regulation of amino acid biosynthetic process
Any process that activates or increases the frequency, rate or extent of myotome development.
positive regulation of myotome development
Any process that activates or increases the frequency, rate or extent of myoblast proliferation.
positive regulation of myoblast proliferation
Any process that modulates the frequency, rate or extent of myotome development.
Any process that modulates the frequency, rate or extent of myoblast proliferation.
Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process.
regulation of apoptosis of endothelial cells
regulation of endothelial cell programmed cell death by apoptosis
regulation of killing of endothelial cells
regulation of programmed cell death of endothelial cells by apoptosis
regulation of programmed cell death, endothelial cells
regulation of endothelial cell apoptosis
regulation of endothelial cell apoptotic process
Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process.
negative regulation of apoptosis of endothelial cells
negative regulation of endothelial cell programmed cell death by apoptosis
negative regulation of killing of endothelial cells
negative regulation of programmed cell death of endothelial cells by apoptosis
negative regulation of programmed cell death, endothelial cells
negative regulation of endothelial cell apoptosis
negative regulation of endothelial cell apoptotic process
Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process.
positive regulation of apoptosis of endothelial cells
positive regulation of endothelial cell programmed cell death by apoptosis
positive regulation of killing of endothelial cells
positive regulation of programmed cell death of endothelial cells by apoptosis
positive regulation of programmed cell death, endothelial cells
positive regulation of endothelial cell apoptosis
positive regulation of endothelial cell apoptotic process
Any process that modulates the frequency, rate or extent of oxygen metabolic process.
regulation of diatomic oxygen metabolic process
Any process that stops, prevents or reduces the frequency, rate or extent of oxygen metabolic process.
negative regulation of diatomic oxygen metabolic process
negative regulation of oxygen metabolism
negative regulation of oxygen metabolic process
Any process that activates or increases the frequency, rate or extent of oxygen metabolic process.
positive regulation of diatomic oxygen metabolic process
positive regulation of oxygen metabolism
positive regulation of oxygen metabolic process
Any process that modulates the frequency, rate or extent of mesoderm development.
Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development.
negative regulation of mesoderm development
Any process that activates or increases the frequency, rate or extent of mesoderm development.
positive regulation of mesoderm development
Any process that modulates the frequency, rate or extent of ectoderm development.
Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development.
negative regulation of ectoderm development
Any process that activates or increases the frequency, rate or extent of ectoderm development.
positive regulation of ectoderm development
Any process that modulates the frequency, rate or extent of lymphocyte migration.
Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte migration.
negative regulation of lymphocyte migration
Any process that activates or increases the frequency, rate or extent of lymphocyte migration.
positive regulation of lymphocyte migration
Any process that modulates the frequency, rate or extent of hematopoietic stem cell migration.
regulation of hemopoietic stem cell migration
regulation of hematopoietic stem cell migration
Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell migration.
negative regulation of hemopoietic stem cell migration
negative regulation of hematopoietic stem cell migration
Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration.
positive regulation of hemopoietic stem cell migration
positive regulation of hematopoietic stem cell migration
Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis.
regulation of cell proliferation involved in compound eye morphogenesis
Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis.
negative regulation of cell proliferation involved in compound eye morphogenesis
Any process that activates or increases the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis.
positive regulation of cell proliferation involved in compound eye morphogenesis
Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation.
Any process that activates or increases the frequency, rate or extent of gastrulation.
Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation.
negative regulation of stem cell proliferation
Any process that activates or increases the frequency, rate or extent of stem cell proliferation.
positive regulation of stem cell proliferation
Any process that modulates the frequency, rate or extent of motor neuron apoptotic process.
regulation of motor neuron apoptotic process
Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process.
negative regulation of motoneuron apoptosis
negative regulation of motor neuron apoptosis
negative regulation of motor neuron apoptotic process
Any process that activates or increases the frequency, rate or extent of motor neuron apoptotic process.
positive regulation of motoneuron apoptosis
positive regulation of motor neuron apoptosis
positive regulation of motor neuron apoptotic process
Any process that modulates the frequency, rate or extent of cardiac muscle cell myoblast differentiation.
regulation of myocardial precursor cell differentiation
regulation of cardiac myoblast differentiation
regulation of cardiac muscle cell myoblast differentiation
Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell myoblast differentiation.
negative regulation of myocardial precursor cell differentiation
negative regulation of cardiac myoblast differentiation
negative regulation of cardiac muscle cell myoblast differentiation
Any process that activates or increases the frequency, rate or extent of cardiac muscle cell myoblast differentiation.
positive regulation of myocardial precursor cell differentiation
positive regulation of cardiac myoblast differentiation
positive regulation of cardiac muscle cell myoblast differentiation
Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation.
regulation of cardiomyocyte differentiation
regulation of heart muscle cell differentiation
regulation of cardiac muscle cell differentiation
Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation.
negative regulation of cardiomyocyte differentiation
negative regulation of heart muscle cell differentiation
negative regulation of cardiac muscle cell differentiation
Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation.
positive regulation of cardiomyocyte differentiation
positive regulation of heart muscle cell differentiation
positive regulation of cardiac muscle cell differentiation
Any process that modulates the frequency, rate or extent of stem cell differentiation.
Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation.
negative regulation of stem cell differentiation
Any process that activates or increases the frequency, rate or extent of stem cell differentiation.
positive regulation of stem cell differentiation
Any process that modulates the frequency, rate or extent of cytoplasmic translation.
Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translation.
negative regulation of cytoplasmic translation
Any process that activates or increases the frequency, rate or extent of cytoplasmic translation.
positive regulation of cytoplasmic translation
Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation involved in lung development.
regulation of mesenchymal cell proliferation involved in lung development
Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell proliferation involved in lung development.
negative regulation of mesenchymal cell proliferation involved in lung development
Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in lung development.
positive regulation of mesenchymal cell proliferation involved in lung development
Any process that modulates the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis.
regulation of epithelial cell proliferation involved in lung morphogenesis
Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis.
negative regulation of epithelial cell proliferation involved in lung morphogenesis
Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation.
negative regulation of myoblast proliferation
Any process that modulates the frequency, rate or extent of heart morphogenesis.
Any process that modulates the frequency, rate or extent of steroid hormone secretion.
Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion.
negative regulation of steroid hormone secretion
Any process that activates or increases the frequency, rate or extent of steroid hormone secretion.
positive regulation of steroid hormone secretion
Any process that modulates the frequency, rate or extent of androgen secretion.
Any process that stops, prevents or reduces the frequency, rate or extent of androgen secretion.
negative regulation of androgen secretion
Any process that activates or increases the frequency, rate or extent of androgen secretion.
positive regulation of androgen secretion
Any process that modulates the frequency, rate or extent of forebrain neuron differentiation.
regulation of forebrain neuron differentiation
Any process that stops, prevents or reduces the frequency, rate or extent of forebrain neuron differentiation.
negative regulation of forebrain neuron differentiation
Any process that activates or increases the frequency, rate or extent of forebrain neuron differentiation.
positive regulation of forebrain neuron differentiation
Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation.
regulation of skeletal muscle cell differentiation
Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell differentiation.
negative regulation of skeletal muscle cell differentiation
Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation.
positive regulation of skeletal muscle cell differentiation
Any process that modulates the frequency, rate or extent of retrograde axon cargo transport.
regulation of retrograde axonal transport
regulation of retrograde axon cargo transport
Any process that stops, prevents or reduces the frequency, rate or extent of retrograde axon cargo transport.
negative regulation of retrograde axonal transport
negative regulation of retrograde axon cargo transport
Any process that activates or increases the frequency, rate or extent of retrograde axon cargo transport.
positive regulation of retrograde axonal transport
positive regulation of retrograde axon cargo transport
Any process that modulates the frequency, rate or extent of tongue muscle cell differentiation.
regulation of tongue muscle cell differentiation
Any process that stops, prevents or reduces the frequency, rate or extent of tongue muscle cell differentiation.
negative regulation of tongue muscle cell differentiation
Any process that activates or increases the frequency, rate or extent of tongue muscle cell differentiation.
positive regulation of tongue muscle cell differentiation
Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process.
regulation of mesenchymal cell apoptosis
regulation of mesenchymal cell apoptotic process
Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process.
negative regulation of mesenchymal cell apoptosis
negative regulation of mesenchymal cell apoptotic process
Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process.
positive regulation of mesenchymal cell apoptosis
positive regulation of mesenchymal cell apoptotic process
Any process that modulates the frequency, rate or extent of RNA biosynthetic process.
Any process that modulates the frequency, rate or extent of vasculogenesis.
Any process that stops, prevents or reduces the frequency, rate or extent of vasculogenesis.
negative regulation of vascular morphogenesis
Any process that activates or increases the frequency, rate or extent of vasculogenesis.
positive regulation of vascular morphogenesis
Any process that modulates the frequency, rate or extent of neuron migration.
Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration.
negative regulation of neuron chemotaxis
negative regulation of neuronal migration
Any process that activates or increases the frequency, rate or extent of neuron migration.
positive regulation of neuron chemotaxis
positive regulation of neuronal migration
Any process that modulates the frequency, rate or extent of apoptotic signaling pathway.
regulation of apoptotic signalling pathway
regulation of apoptotic signaling pathway
Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway.
negative regulation of apoptotic signalling pathway
negative regulation of apoptotic signaling pathway
Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway.
positive regulation of apoptotic signalling pathway
positive regulation of apoptotic signaling pathway
Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization.
negative regulation of chromosome organisation
negative regulation of chromosome organization and biogenesis
negative regulation of maintenance of genome integrity
negative regulation of nuclear genome maintenance
negative regulation of chromosome organization
Any process that activates or increases the frequency, rate or extent of chromosome organization.
positive regulation of chromosome organisation
positive regulation of chromosome organization and biogenesis
positive regulation of maintenance of genome integrity
positive regulation of nuclear genome maintenance
positive regulation of chromosome organization
A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities
A quality of inhering in a bearer by virtue of the bearer's disposition to move freely.
A physical quality inhering in a bearer by virtue of the bearer's scalar absolute value of the rate of change of the bearer's position.
A time quality inhering in a bearer by virtue of how long the bearer has existed.
A composite chromatic quality composed of hue, saturation and intensity parts.
A chromatic scalar-circular quality inhering in an object that manifests in an observer by virtue of the dominant wavelength of the visible light; may be subject to fiat divisions, typically into 7 or 8 spectra.
A scalar optical property that is the intensity, value or amount of perceived light.
Color brightness refers to the intensity, lightness or value of the light present. Think of this as a dimmer switch.
A scalar chromatic property that is the degree of purity of perceived light.
Color saturation refers to the amount of white light or gray paint mixed in with the hue (single wavelength) and is a measure of color purity.
A luminous flux quality inhering in a bearer by virtue of the bearer's emitting longer wavelength light following the absorption of shorter wavelength radiation; fluorescence is common with aromatic compounds with several rings joined together.
A chromatic property that is the relative position of different hues or degrees of saturation.
A quality inhering in a bearer by virtue of the bearer's disposition to harmonious coexistence.
Needs redefined or obsoleted. Is this the same as genetic incompatibility? Moved to organismal quality.
A single physical entity inhering in an bearer by virtue of the bearer's quantities or relative ratios of subparts.
For example calcium composition (which may inhere in bone), haemoglobin composition (which may inhere in blood).
A quality inhering in a substance by virtue of the amount of the bearer's there is mixed with another substance.
A physical quality inhering in a bearer by virtue of the bearer's density, firmness, or viscosity.
A physical quality inhering in a bearer by virtue of the bearer's orientation in space.
TODO: consider merging with angular placement.
A quality that is the extent of space between two entities.
A quality of a physical entity inhering in a bearer by virtue of whether the bearer's molecules are being perceived by a taste and odorant receptors.
A physical quality which inheres in a bearer by virtue of the number of the bearer's repetitive actions in a particular time.
An organismal quality inhering in a bearer by virtue of the bearer's ability to undergo sexual reproduction in order to differentiate the individuals or types involved.
A physical quality inhering in a bearer by virtue of the bearer's resistance to pressure, being broken, or pierced
A quality inhering in a bearer by virtue of the bearer's possessing or displaying a distinctive feature in type or degree or effect or force.
A time quality inhering in a bearer by virtue of the bearer's expected maximum age.
A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure.
A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc).
Shapes are invariant on size transformations. Shapes can be subdivided into 2D and 3D shapes, We can also make a distinction between shapes of complete self-connected objects, and shapes of parts of objects.
An organismal quality inhering in a bearer by virtue of the bearer's disposition to synthesize a particular organic compound required for its growth.
A quality of a single process inhering in a bearer by virtue of the bearer's occurrence.
A physical quality inhering in a bearer by virtue of the bearer's molecules being are aerially dispersed and perceived by an odorant receptor.
A parental quality inhering in a bearer by virtue of exhibiting the characteristic of a parent.
A spatial quality inhering in a bearer by virtue of the bearer's exhibiting repetition of placement of its parts.
A sleep quality defined by the mathematic properties of the relative time frames of the sleep cycle.
A texture quality inhering in a bearer by virtue of the bearer's having hair or bristles.
A quality of an entity that is descriptive or observational, typically not represented numerically.
TODO: define this or obsolete it and move children somewhere else.
A quality inhering in a bearer by virtue of the whether the bearer differs from normal or average.
The number of entities of this type that are part of the whole organism.
This term was originally named "presence". It has been renamed to reduce ambiguity. Consider annotating with the reciprocal relation,PATO:0001555, has_number_of. For example, rather than E=fin ray Q=count in organism C=10, say E=organism Q=has number of E2= fin ray C=10.
A quality inhering in a bearer by virtue of the whether the bearer's disposition to react to a stimulus or an agent.
A quality of a single process inhering in a bearer by virtue of the bearer's movement or variation characterized by the regular recurrence or alternation of different quantities or conditions.
A physical quality of a process inhering in a bearer by virtue of the size of the bearer's maximum displacement from the 'normal' position, when periodic motion is taking place.
A rhythm quality inhering in a bearer by virtue of the repetitiveness of bearer's rhythm.
A quality that exists by virtue of being a particular point in the time of a cycle.
A quality inhering in a bearer by virtue of the bearer's disposition to detect or perceive external stimulation.
obsolete plant growth hormone sensitivity
obsolete absolute temperature sensitivity
obsolete relative temperature sensitivity
A morphology quality inhering in a bearer by virtue of the bearer's physical magnitude.
A 1-D extent quality inhering in a bearer by virtue of the bearer's vertical dimension of extension.
A 1-D extent quality which is equal to the distance between two points.
Length often refers to the longer or longest dimension of an object, however, this is not always true. See https://github.com/pato-ontology/pato/issues/337 for full discussion.
A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter.
For any biological use of PATO, the concept that should be used is 'mass' and not 'weight'. For example, increased weight of an organism.
A physical quality inhering in a bearer that has mass near a gravitational body. Important usage note: Note that this ontology has a class for a similar concept, mass (PATO:0000125). Mass and weight are not equivalent. For most use cases, the class mass is strongly preferred over weight.
A spatial quality inhering in a bearer by virtue of the bearer's placement which is defined by the angle between the bearer and an axis, or the angle between the bearer and another object.
A morphological quality pertaining to the degree to which an object contains an opening, aperture, orifice or vent.
A spatial quality inhering in a bearer by virtue of the bearer's spatial location relative to other objects in the vicinity.
A morphology quality inhering in a bearer by virtue of the bearer's relative position, shape, arrangements and connectivity of an organism's various parts; the pattern underlying its form.
This term was made obsolete because it is not a quality. To update annotations, consider the following term 'quality of a solid; 'PATO:0001546'
This term was made obsolete because it is not a quality. To update annotations, consider the following term 'quality of a liquid; PATO:0001548 '
A physical quality of the thermal energy of a system.
A morphologic quality inhering in a bearer by virtue of the bearer's relative size, organization and distribution of its surface elements or the representation or invention of the appearance of its surface; visual and tactile surface characteristics.
A quality inhering in a bearer by virtue of the bearer's sensitivity towards a fixed location or value where a change is observed; upper limit.
A quality of a single process inhering in a bearer by virtue of the bearer's occurrence per unit time.
A quality in which events occur in sequence.
A limited, often assigned period of activity.
An organismal quality inhering in a bearer or a population by virtue of the bearer's disposition to survive and develop normally or the number of surviving individuals in a given population.
A behavioral quality inhering in a bearer by virtue of having physical steadiness.
An organismal quality inhering in a bearer by virtue of the bearer's behavior aggregate of the responses or reactions or movements in a given situation.
A relational quality of occurrent inhering in a bearer by virtue of the bearer's ability to consume a resource.
A behavioral quality inhering in a bearer by virtue of the bearer's having or lacking skillful and effective interaction of movement.
A behavioral quality inhering in a bearer by virtue of whether the bearer's disposition to perceive differences between two or more stimuli.
A quality of a single physical entity which is held by a bearer when the latter exhibits a state of growth, differentiation, or development.
obsolete relative neurobehavioral function
A reproductive quality inhering in an organism or population by virtue of the bearer's potential reproductive capacity ad measured by the number of gametes.
A reproductive quality inhering in a bearer by virtue of the bearer's initiating, sustaining, or supporting reproduction.
A reproductive quality inhering in the young of an animal by virtue of their number.
A fertility quality inhering in a female by virtue of the bearer's disposition to initiate, sustain, or support reproduction.
A fertility quality of inhering in a male by virtue of the bearer's disposition to initiate, sustain, or support reproduction.
A quality of a process which ends earlier than the natural end time or reference process.
TODO: the definition is incorrect. See absent.
A mobility quality of inhering in a bearer by virtue of the bearer's disposition to move freely.
A mobility quality inhering in a bearer by virtue of the bearer's being incapable to move freely.
A color hue with low wavelength of that portion of the visible spectrum lying between green and indigo, evoked in the human observer by radiant energy with wavelengths of approximately 420 to 490 nanometers.
A color consisting of green and blue hue.
A color hue with medium-low wavelength of that portion of the visible spectrum lying between yellow and blue, evoked in the human observer by radiant energy with wavelengths of approximately 490 to 570 nanometers.
A color consisting of red and blue hues.
A color hue with high wavelength of the long-wave end of the visible spectrum, evoked in the human observer by radiant energy with wavelengths of approximately 630 to 750 nanometers.
An achromatic color of maximum brightness; the color of objects that reflect nearly all light of all visible wavelengths.
A color hue with medium wavelength of that portion of the visible spectrum lying between orange and green, evoked in the human observer by radiant energy with wavelengths of approximately 570 to 590 nanometers.
A color brightness which is relatively low.
A color saturation which is of low purity.
A color pattern inhering in a bearer by virtue of bearer's being marked with irregularly shaped spots or blots of a different hue or degree of saturation.
A spatial pattern inhering in a bearer by virtue of the bearer's magnitude of or the relationships between its repeated parts lack consistency.
A color quality inhering in a bearer by virtue of the bearer's being altered or spoiled in color.
A color pattern inhering in a bearer by virtue of bearer's being marked with a round area of different hue or degree of saturation.
A color quality inhering in a bearer by virtue of the bearer's having color.
A color quality inhering in a bearer by virtue of the bearer's lacking color.
obsolete gametophytic compatability value
obsolete sporophytic compatability value
A compatibility quality inhering in a bearer by virtue of the bearer's being capable of harmonious coexistence.
A compatibility quality inhering in a bearer by virtue of the bearer's being incapable of harmonious coexistence.
obsolete macromolecular composition value
obsolete secondary product composition value
A directional quality inhering in a bearer by virtue of the bearer's direction from a higher to a lower point.
A directional quality inhering in a bearer by virtue of the bearer's direction that is similar to the direction of an object to the north when it faces east.
A directional quality inhering in a bearer by virtue of the bearer's direction that is similar to the direction of an object to the north when it faces west.
A directional quality inhering in a bearer by virtue of the bearer's direction from a lower to a higher point.
A distance which is greater relative to the normal or average.
A distance which is lesser relative to the normal or average.
A biological sex quality inhering in an individual or a population that only produces gametes that can be fertilised by male gametes.
A biological sex quality inhering in an individual or a population whose sex organs contain only male gametes.
A hardness quality of being rigid and resistant to pressure.
A hardness quality of giving little resistance to pressure.
A quality of a process inhering in a bearer by virtue of the bearer's having a sudden onset, sharp rise, and short course.
An intensity which is less than moderate in type or degree or effect or force.
An intensity which is less than extreme in type or degree or effect or force.
An intensity which is extremely bad or unpleasant in type or degree or effect or force.
A branchiness quality inhering in a bearer by virtue of the bearer's having branches.
A concave quality inhering in a bearer by virtue of the bearer's resembling a groove or fissure.
A shape quality inhering in a bearer by virtue of the bearer's being curled or wound (especially in concentric rings or spirals).
A shape quality inhering in a bearer by virtue of the bearer's having parallel chains in undulate fashion on the border.
A curvature quality inhering in a bearer by virtue of the bearer's having or being marked by a curve or smoothly rounded bend.
A quality inhering in a bearer by virtue of the bearer's having a horizontal surface without a slope, tilt, or curvature.
A spheroid quality inhering in a bearer by virtue of the bearer's exhibiting an equatorial diameter greater than its polar diameter.
A shape quality inhering in a bearer by virtue of the bearer's having leaflets or leaflets-like structures on each side of a common axis.
A shape quality inhering in a bearer by virtue of the bearer's being such that every part of the surface or the circumference is equidistant from the center.
A shape quality inhering in a bearer by virtue of the bearer's having an equal-sided rectangular form.
A branchiness quality inhering in a bearer by virtue of the bearer's lacking branches.
A shape quality inhering in a bearer by virtue of the bearer's being not curled or wound (especially in concentric rings or spirals).
A nutritional quality inhering in a bearer by virtue of the bearer's inability to synthesize a particular organic compound required for its growth.
A nutritional quality inhering in a bearer by virtue of the bearer's ability to synthesize a particular organic compound required for its growth.
A quality of a single process inhering in a bearer by virtue of the bearer's occurring or appearing again or repeatedly.
A quality of a single process inhering in a bearer by virtue of the bearer's once or in or a few unpredictable instances.
A parental quality inhering in a bearer by virtue of exhibiting the characteristic of a father.
A parental quality inhering in a bearer by virtue of exhibiting the characteristic of a mother.
A variability quality inhering in a bearer by virtue of the bearer's lacking or not exhibiting variation.
A pattern quality inhering in a bearer by virtue of the bearer's having a repeatable or predictable placement.
A quality of a single process inhering in a bearer by virtue of the bearer's marked by tedious repetition.
A sleep pattern quality inhering in a bearer by virtue of the bearer's inability to sleep.
A sleep pattern quality inhering in a bearer by virtue of the bearer's disrupted sleep during normal sleeping period; often accompanied by cataplexy, sleep paralysis.
A pilosity quality inhering in a bearer by virtue of the bearer's lack of hairs or bristles.
A pilosity quality inhering in a bearer by virtue of the bearer's being covered with hair or hairlike projections.
A maturity quality inhering in a bearer by virtue of the bearer's having arrived at the onset of puberty (the age at which sex glands become functional) but not yet fully mature.
A quality inhering in a bearer by virtue of the bearer's deviation from normal or average.
A quality inhering in a bearer by virtue of the bearer's exhibiting no deviation from normal or average.
A quality denoting the lack of an entity.
We recommend using the new absent terms (physical absence, absent anatomical entity, or absent process) instead of this class. This is a legacy term and will ultimately be obsoleted. See https://github.com/pato-ontology/pato/issues/331.
A quality inhering in a bearer by virtue of being clearly visible.
A quality inhering in a bearer by virtue of not being clearly visible.
A quality inhering in a bearer by virtue of the bearer's existence.
A response quality inhering in a bearer by virtue of the bearer's disposition to react to a stimulus or an agent.
A response quality inhering in a bearer by virtue of the bearer's lack of reaction to a stimulus or an agent.
A duration quality of a process which is relatively high.
A duration quality of a process which is relatively low.
A phase which occurs earlier than the natural start time.
A quality of a process which starts later than the natural start time or the reference process.
A phase which occurs during the light cycle.
A rhythm quality inhering in a bearer by virtue of the bearer's lacking rhythm.
A rhythm quality inhering in a bearer by virtue of the bearer's having rhythm.
obsolete absolute disease sensitivity value
obsolete relative disease sensitivity value
A quality inhering in a bearer by virtue of the bearer's lacking sensitivity toward an external stimulus.
A resistance quality inhering in a bearer by virtue of its disposition to endure or being insensitive to a stimulus.
A quality inhering in a bearer by virtue of the bearer's having sensitivity toward an external stimulus.
obsolete abiotic stress sensitivity value
obsolete plant growth hormone sensitivity value
obsolete soil composition sensitivity value
obsolete absolute drug sensitivity value
obsolete relative drug sensitivity value
obsolete soil nutrient sensitivity value
obsolete macronutrient sensitivity value
obsolete micronutrient sensitivity value
obsolete absolute photosensitivity value
obsolete light intensivity sensitivity value
obsolete light_quality sensitivity value
obsolete relative photosensitivity value
A photosensitivity quality inhering in a bearer by virtue of the bearer's lacking photosensitivity.
A photosensitivity quality inhering in a bearer by virtue of the bearer's exhibiting photosensitivity.
obsolete far red light sensitivity value
obsolete absolute temperature sensitivity value
obsolete relative temperature sensitivity value
A length quality which is relatively large.
A length quality which is relatively small.
An increased size quality inhering in a bearer by virtue of the bearer's exhibiting enlargement of a cell or constituent group of cells (for example, organ).
A decreased size quality inhering in a bearer by virtue of the bearer's exhibiting reduced size of a cell or constituent group of cells (for example, organ).
A size quality which is relatively high.
A quality inhering in a bearer by virtue of the bearer's being a remnant structure from earlier development or evolution.
May be part of an animal (such as an organ or bone) that is no longer used by the species and has therefore become smaller or less developed.
A morphological quality inhering in a bearer by virtue of the bearer's affording blocked passage or view.
A morphological quality inhering in a bearer by virtue of the bearer's affording not completed blocked passage or view.
A morphological quality inhering in a bearer by virtue of the bearer's affording unobstructed passage or view.
A spatial pattern inhering in a bearer by virtue of the bearer's lacking orientation.
A pattern where all the repeated elements are oriented in the same direction.
An anteriorized quality inhering in a bearer by virtue of the bearer's gross morphology containing only what are normally anterior structures.
A symmetry quality inhering in a bearer by virtue of the bearer's lacking symmetry.
A shape quality inhering in a bearer by virtue of the bearer's having one or more angle(s) in its length.
A positional quality inhering in a bearer by virtue of the bearer's having two sides; two-sided.
A positional quality inhering in a bearer by virtue of the bearer's being overfilled.
A dorsalized quality inhering in a bearer by virtue of the bearer's gross morphology containing only what are normally dorsal structures.
A positional quality inhering in a bearer by virtue of the bearer's being upright in position or posture.
A quality inhering in a bearer by virtue of the bearer's protruding or projecting from the body.
A spatial quality inhering in a bearer by virtue of the bearer's becoming joined together with an additional entity.
An oriented quality inhering in a bearer by virtue of the bearer's being reversed in position, order, or condition.
A positional quality inhering in a bearer by virtue of the bearer's being moved or displaced to one side so as to make lateral.
A spatial pattern quality inhering in a bearer by virtue of the bearer's being confined or restricted to a particular location.
A positional quality inhering in a bearer by virtue the bearer's being changed in abnormal position.
A positional quality inhering in a bearer by virtue of the bearer's having mistakenly taken course, way, or passage; ill-routed.
A posteriorized quality inhering in a bearer by virtue of the bearer's gross morphology containing only what are normally posterior structures.
A positional quality inhering in a bearer by virtue of the bearer's being stretched out and lying at full length along the ground.
A symmetry quality inhering in a bearer by virtue of the bearer's being capable of division by a longitudinal plane into similar halves.
A spatial pattern inhering in a bearer by virtue of the bearer's being not overfilled.
A spatial pattern inhering in a bearer by virtue of the bearer's involvement of only one part or side.
A spatial pattern inhering in a bearer by virtue of the bearer's not being confined or restricted to a particular location.
A ventralized quality inhering in a bearer by virtue of the bearer's gross morphology containing only what are normally ventral structures.
A structural quality inhering in a bearer by virtue of the bearer's consisting of blebbing of the nucleus and DNA fragmentation due to the cell undergoing a specific form of programmed cell death termed apoptosis.
A structural quality inhering in a bearer whose structure deteriorates or is lost over time due to an active pathological process.
A structural quality inhering in a bearer by virtue of the bearer's exhibiting an alteration in size, shape or organization of its constituent cells.
A structural quality inhering in a bearer by virtue of the bearer's being merged with another entity.
A quality inhering in a bearer by virtue of the bearer's bodily structure that has protruded through an abnormal opening in the wall that contains it.
A physical quality inhering in an organ or tissue by virtue of the bearer's exhibiting an increased number of cells, typically associated with an increase in size.
A physical quality inhering in an organ or tissue by virtue of the bearer's exhibiting a decreased number of cells, typically associated with a decrease in size.
A morphological quality inhering in a bearer by virtue of the bearer's being distorted during formation.
A structural quality inhering in a bearer by virtue of the bearer's undergoing unprogrammed cell death.
A morphological quality inhering in a bearer by virtue of the bearer's being blocked or filled with obstacles or an obstacle.
A structural quality inhering in a bearer by virtue of the bearer's being no longer merged with another entity.
A color brightness which is relatively high.
A quality of a single process inhering in a bearer by virtue of the bearer's not occurring or existing at the same time or having the same period or phase.
A quality of a single process inhering in a bearer by virtue of the bearer's being uninterrupted in time, sequence, substance, or extent.
A quality of a single process inhering in a bearer by virtue of the bearer's being marked by breaks or interruptions.
A quality of a single process inhering in a bearer by virtue of the bearer's origin or development at an unusual time or out of the regular sequence.
A quality of a process which starts earlier than the natural start time or the reference process.
A quality of a single process inhering in a bearer by virtue of the bearer's occurring or existing at the same time or having the same period or phase.
A texture quality inhering in a bearer by virtue of the bearer's irregular surface.
A texture quality inhering in a bearer by virtue of the bearer's processing a surface free of roughness or irregularities.
A viability quality inhering in a population by virtue of the bearer's long term survival inability.
A viability quality inhering in a bearer or a population by virtue of the bearer's ability to survive or the long term survival ability of a given population.
A balance quality inhering in a bearer by virtue of the bearer's having balance.
A balance quality inhering in a bearer by virtue of the bearer's lacking balance.
A behavioral quality inhering in a bearer by virtue of the bearer's exhibiting paralytic behaviour when subjected to mechanical shock.
A behavioral quality of a process inhering in a bearer by virtue of the bearer's exhibiting increased activity.
A behavioral quality of a process inhering in a bearer by virtue of the bearer's exhibiting reduced activity.
A behavioral quality inhering in a bearer by virtue of the bearer's being affected by loss of the ability to move a body part.
A behavioral quality inhering in a bearer by virtue of the bearer's receiving or being subjected to an action without responding or initiating an action in return.
A coordination quality of inhering in a bearer by virtue of the bearer's having skillful and effective interaction of movement.
A coordination quality of inhering in a bearer by virtue of the bearer's lacking skillful and effective interaction of movement.
A preference quality in a bearer by virtue of the bearer's disliking a perceived stimulus.
A preference quality in a bearer by virtue of the bearer's having no preference to a perceived stimulus.
A discrimination quality in a bearer by virtue of the bearer's liking a perceived stimulus.
obsolete absolute locomotor activity value
obsolete relative locomotor activity value
obsolete absolute visual threshold value
obsolete relative visual threshold value
obsolete absolute auditory ability value
obsolete relative auditory ability value
obsolete absolute auditory threshold value
obsolete relative auditory threshold value
obsolete proboscis extension reflex value
obsolete relative neurobehavioral function value
obsolete absolute respiratory rate value
obsolete relative respiratory rate value
A female fertility quality inhering in a female by virtue of the bearer's disposition to initiate, sustain, or support reproduction.
obsolete cytoplasmic male sterility value
A male fertility quality inhering in a male by virtue of the bearer's being incapable of initiating, sustaining, or supporting reproduction.
A male fertility quality inhering in a male by virtue of the bearer's being capable of initiating, sustaining, or supporting reproduction.
A female fertility quality inhering in a female by virtue of the bearer's being incapable of initiating, sustaining, or supporting reproduction.
obsolete germ line dependent fertility value
A 1-D extent quality which is equal to the dimension through an object as opposed to its length or width.
Thickness often refers to the smallest 1-D extent compared to the other two orthogonal dimensions, however, this is not always true. See https://github.com/pato-ontology/pato/issues/337 for full discussion.
A 3-D extent quality inhering in a bearer by virtue of the bearer's amount of 3-dimensional space it occupies.
A 1-D extent quality which is equal to the distance from one side of an object to another side which is opposite.
Width often refers to the dimension that is greater than the extent in only one of the other two orthogonal dimensions, however, this is not always true. See https://github.com/pato-ontology/pato/issues/337 for full discussion.
A quality inhering in a bearer by virtue of the bearer's disposition to being sensitivity to the action of radiant energy.
A shape quality inhering in a bearer by virtue of the bearer's terminating abruptly by having or as if having an end or point cut off.
A structural quality inhering in a bearer by virtue of the bearer's lacking organisation.
A structural quality inhering in a bearer by virtue of the bearer's exhibiting organisation.
A structural quality inhering in a cytoplasm that contains fluid filled cavities.
A shape quality inhering in a bearer by virtue of the bearer's having a sharp or tapered end or point.
A shape quality inhering in a bearer by virtue of the bearer's exhibiting a downward bending of its leaves or other plant parts.
A shape quality inhering in a bearer by virtue of the bearer's having a somewhat elongated form with approximately parallel sides.
A spheroid quality inhering in a bearer by virtue of the bearer's being oval with two axes of symmetry, as produced by a conical section.
A concave 3-D shape quality inhering in a bearer by virtue of the bearer's having a sinus or rounded lobe at the base.
A shape quality inhering in a bearer by virtue of the bearer's being abnormally flattened or coalesced.
A color that falls about midway between red and blue in hue.
A color consisting of dark orange, red, of very low intensity.
A color hue with high-medium wavelength that of that portion of the visible spectrum lying between red and yellow, evoked in the human observer by radiant energy with wavelengths of approximately 585 to 620 nanometers.
Red color having medium to high brightness and low to moderate saturation.
A fertility quality inhering in a bearer by virtue of the bearer's being capable of initiating, sustaining, or supporting reproduction.
A fertility quality inhering in a bearer by virtue of the bearer's being incapable of initiating, sustaining, or supporting reproduction.
An optical quality which obtains by virtue of the ability of the bearer to absorb visible light.
A optical quality inhering in a bearer by virtue of the bearer's not being clear; not transmitting or reflecting light or radiant energy.
A optical quality inhering in a bearer by virtue of the bearer's lacking opacity.
A pattern quality of inhering in a bearer by virtue of the correspondence in size, shape, and relative position of the bearer's parts on opposite sides of a dividing line or median plane or about a center or axis.
A shape quality inhering in a bearer by virtue of the bearer's having a sinuate margin and rippled surface.
A size quality inhering in a bearer by virtue of the bearer's being abnormally small.
A structural quality inhering in a bearer by virtue of the bearer's disposition to being permeated or pervaded by a gas or liquid (as by osmosis or diffusion).
A structure quality inhering in a bearer by virtue of the bearer's disposition to admit the passage of gas or liquid through pores or interstices.
A permeability quality inhering in a bearer by virtue of the bearer's being capable to be permeated or pervaded by a gas or liquid (as by osmosis or diffusion).
A permeability quality inhering in a bearer by virtue of the bearer's being incapable of being permeated or pervaded by a gas or liquid (as by osmosis or diffusion).
A porosity quality inhering in a bearer by virtue of the bearer's being capable of admitting the passage of gas or liquid through pores or interstices.
A porosity quality inhering in a bearer by virtue of the bearer's being incapable of admitting the passage of gas or liquid through pores or interstices.
A physical quality of a fluid inhering in a bearer by virtue of the bearer's disposition to internal resistance to flow.
A viscosity quality inhering in a bearer by virtue of the bearer's having viscosity.
A quality of a single process inhering in a bearer by virtue of the bearer's successive change from one thing or state to another and back again.
A time quality inhering in a bearer by virtue of the time it elapses for the bearer to respond to a stimulus.
This class is a candidate for obsoletion. The definition is not clear, and the placement under "delayed" is not consistent with the definition.
A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities.
A physical quality which inheres in a bearer by virtue of some influence is exerted by the bearer's mass per unit size.
A structural quality inhering in a bearer by virtue of whether the bearer has been harmed or injured or spoiled.
A physical quality inhering in a bearer by virtue of the bearer's capacity to do work.
A physical quality inhering in a bearer by virtue of the amount of momentum caused a certain force will produce over time.
A physical quality inhering in a bearer by virtue of the bearer's velocity multiplied by its mass.
A physical quality inhering in a bearer by virtue of the bearer's rate of doing work.
A physical quality that inheres in a bearer by virtue of the bearer's amount of force per unit area it exerts.
A physical quality which is equal to the energy transferred by a force to a moving object.
A physical quality inhering in a bearer by virtue of the rate of change of the bearer's velocity in either speed or direction.
A physical quality inhering in a bearer by virtue of ratio of the bearer's output to the bearer's input.
A physical quality that exists by virtue of the rate of flow of the bearer across a given surface.
A physical quality inhering in a bearer by virtue of the bearer's disposition to recover its size and shape after deformation in any way.
A physical quality inhering in a bearer by virtue of the relative change in the bearer's length or the bearer's volume when being stretched or squashed.
A physical quality inhering in a bearer by virtue of the bearer's rate of change of momentum.
A quality inhering in an entity by virtue of the bearer's propensity to resist an external stimulus.
A quality inhering in a bearer by virtue of the bearer's disposition to resist to a stimulus.
An angle which is between 90 degrees and 180 degrees to another entity.
An angle which is less than 180 degrees to another entity.
A convex angle that is inside two adjacent sides of a polygon.
An angular placement quality inhering in a bearer by virtue of the bearer's placement at an angle that is greater than 180 degrees but less than 360 degrees to another entity.
obsolete immunoglobulin concentration value
A quality inhering in a bearer by virtue of the bearer's having susceptibilty toward an external stimulus.
A quality inhering in a bearer by virtue of the bearer's lacking susceptibilty toward an external stimulus.
A quality inhering in a bearer by virtue of the bearer's length being notably higher than its width.
A concentration quality inhering in a bearer by virtue of the bearer's exhibiting concentration.
A concentration which is higher relative to the normal or average.
A concentration which is lower relative to the normal or average.
A physical quality which inheres in a bearer by virtue of the bearer's exhibiting density.
A structural quality inhering in a bearer by virtue of the bearer being harmed or injured or spoiled, such that its functionality is impaired.
A structural quality inhering in a bearer by virtue of not being harmed or injured or spoiled.
An elasticity quality inhering in a bearer by virtue of the bearer's ability to recover its size and shape after deformation in any way.
An elasticity quality inhering in a bearer by virtue of the bearer's inability to recover its size and shape after deformation in any way.
obsolete urine glucose composition value
A resistance quality inhering in a bearer by virtue of the bearer's resistance to a stimulus.
A maturity quality inhering in a bearer by virtue of the bearer's indirect development, undergoing metamorphosis.
A maturity quality inhering in a bearer by virtue of the bearer's being at the age immediately before puberty.
A maturity quality inhering in a insect by virtue of the bearer's being in the chrysalis (cocoon) or post larval stage.
A maturity quality inhering in a bearer by virtue of the bearer's being in an inactive stage in the development of some insects, between the larval and the pupal stages.
A maturity quality inhering in a bearer by virtue of the bearer's being between the onset of puberty and maturity.
A maturity quality inhering in a bearer by virtue the bearer's being not fully grown or developed.
A spatial quality inhering in a bearer by virtue of the bearer's being located toward the middle relative to another entity.
A response quality inhering in a bearer by virtue of the bearer's excessive reaction to a stimulus or an agent.
A spatial quality inhering in a bearer by virtue of the bearer's being located toward the side relative to another entity.
A response quality inhering in a bearer by virtue of the bearer's limited reaction to a stimulus or an agent.
A spatial quality inhering in a bearer by virtue of the bearer's being located more centrally than another entity.
A spatial quality inhering in a bearer by virtue of the bearer's being located toward the abdomen of an organism relative to another entity.
A shape quality inhering in a bearer by virtue of the bearer's being narrow, with the two opposite margins parallel.
A concave 3-D shape quality inhering in a bearer by virtue of the bearer's being shaped in the form of the letter T.
A concave 3-D shape quality inhering in a bearer by virtue of the bearer's being shaped in the form of the letter Y.
A surface feature shape quality inhering in a bearer by virtue of the bearer's having toothlike projections in the margin.
A shape quality inhering in a bearer by virtue of having sharp straight-edged teeth pointing to the apex.
An odor quality inhering in a bearer by virtue of the bearer's lacking odour.
A variability quality inhering in a bearer by virtue of whether the bearer exhibits variation or change.
A color saturation which is of high purity.
A quality inhering in a bearer by virtue of the bearer's power or force.
A spatial quality inhering in a bearer by virtue of the bearer's being located toward the back or upper surface of an organism relative to another entity.
A spatial quality inhering in a bearer by virtue of the bearer's being located further from a more centrally located entity.
See comments of relational quality of a physical entity.
A quality which inheres in a continuant.
multiply inhering quality of a physical entity
Relational qualities are qualities that hold between multiple entities. Normal (monadic) qualities such as the shape of a eyeball exist purely as a quality of that eyeball. A relational quality such as sensitivity to light is a quality of that eyeball (and connecting nervous system) as it relates to incoming light waves/particles.
A physical quality which is equal to the distance between repeating units of a wave pattern.
A color consisting of blue hue and high brightness.
A color consisting of blue hue and low brightness.
A color consisting of brown hue and low brightness.
A color consisting of brown hue and high brightness.
A color consisting of cyan hue and high brightness.
A color consisting of cyan hue and low brightness.
A color consisting of green hue and low brightness.
A color consisting of green hue and high brightness.
A color consisting of grey color and low brightness.
A color consisting of grey color and high brightness.
A color consisting of magenta color and high brightness.
A color consisting of magenta with low brightness.
A color consisting of orange hue and high brightness.
A color consisting of orange color and low brightness.
Pink color having high brightness and moderate saturation.
Pink color having medium brightness and moderate saturation.
A color consisting of purple color and low brightness.
A color consisting of purple color and high brightness.
A color consisting of red hue and low brightness.
A color consisting of red hue and high brightness.
A color consisting of yellow hue and low brightness.
A color consisting of yellow hue and high brightness.
A color consisting of blue hue and high saturation.
A color consisting of blue hue and low saturation.
A color consisting of brown hue and high saturation.
A color consisting of brown hue and low saturation.
A color consisting of cyan colour and high saturation.
A color consisting of cyan colour and low saturation.
A color consisting of green hue and high saturation.
A color consisting of green hue and low saturation.
A color consisting of grey color and high saturation.
A color consisting of grey color and low saturation.
A color consisting of magenta color and high saturation.
A color consisting of magenta color and low saturation.
A color consisting of orange hue and high saturation.
A color consisting of orange hue and low saturation.
Pink color having medium brightness and low saturation.
A color consisting of purple color and high saturation.
A color consisting of purple color and low saturation.
A color consisting of red hue and high saturation.
A color consisting of red hue and low saturation.
A color consisting of yellow hue and high saturation.
A color consisting of yellow hue and low saturation.
A color consisting of red and brown hue.
A color consisting of red and brown hue and low brightness.
A color consisting of red and brown hue and high brightness.
A fluorescence quality inhering in a bearer by virtue of emitting light during exposure to radiation from an external source.
OBSOLETE A radiation quality that inheres in a bearer by virtue of how that bearer interacts with electromagnetic radiation.
See https://github.com/pato-ontology/pato/issues/490
obsolete electromagnetic (EM) radiation quality
An EM radiation quality that is independent of the EM wavelength range.
A scalar EM radiation quality which obtains by the capacity of the bearer to retain radiation.
A scalar EM radiation quality which obtains by the capacity of the bearer to scatter or reflect radiation.
A reflective quality restricted to a particular wavelength.
Typically used for light, but also applied to full EM spectrum.
A scalar optical quality which obtains by the magnitude of the light emitted by the bearer.
A radiation reflective quality inhering in a bearer by virtue of the ratio of the energy of a wave reflected from its surface to the energy possessed by the wave striking the bearer's surface.
A fluorescence in which the emittence continues after the absorption has ceased.
A scalar EM radiation quality which obtains by the capacity of the bearer to emit radiation.
An EM radiation quality in which the EM radiation is within the fiat range of the spectrum visible deemed to be light.
An optical quality that is the mixture, purity or pattern of wavelengths of light perceived by the observer.
A color consisting of red and orange hue with a slight amount of gray.
A quality inhering in a bearer by virtue of the bearer's disposition to varying or changing.
A variability quality inhering in a bearer by virtue of whether the bearer exhibits temperature variation or change.
A variability of temperature which is relatively low.
A variability of temperature which is relatively high.
A process quality inhering in a bearer by virtue of the bearer's magnitude of the temporal extent between the starting and ending point.
A duration quality of a process inhering in a bearer by virtue of the bearer's duration of exhibition of thermal energy.
TODO: obsolete? I don't know what this means.
A duration of temperature which is lesser relative to the normal or average enduring or continuing in time.
A duration of temperature which is greater relative to the normal or average in respect to the quality of temperature of enduring or continuing in time.
A variability quality inhering in a bearer by virtue of the bearer's lacking or not exhibiting variation of temperature.
A variability quality inhering in a bearer by virtue of the bearer's having or exhibiting variation of temperature.
A temperature which is increased by a low degree.
A temperature which is increased by a medium degree.
A temperature which is increased by a high degree.
A discrimination quality in a bearer by virtue of the bearer's being incapable perceiving differences between two or more stimuli.
A discrimination quality in a bearer by virtue of the bearer's being capable of perceiving differences between two or more stimuli.
A pilosity quality of being covered with short hairs or soft down.
An angle which is 90 degrees to another entity.
An angle which is 180 degrees to another entity.
A 2-D extent quality inhering in a bearer by virtue of the bearer's two dimensional extent.
A symmetry quality inhering in a bearer by virtue of the bearer's being symmetric about a plane running from its frontal end to its caudal end (head to tail), and has nearly identical right and left halves.
A symmetry quality inhering in a bearer by virtue of the bearer's having equal proportion around a central point or axis.
A symmetry quality inhering in a bearer by virtue of the bearer's being capable of division into symmetrical halves by only one longitudinal plane passing through the axis.
A symmetry quality inhering in a bearer by virtue of the bearer's being capable of division into symmetrical halves by any longitudinal plane passing through the axis.
A flavor quality inhering in a bearer by virtue of the bearer's having flavour.
A flavor quality inhering in a bearer by virtue of the bearer's lacking flavour.
An odor quality inhering in a bearer by virtue of the bearer's having odour.
A morphology quality inhering in a bearer by virtue of the bearer's lack of distinct morphology.
A quality of a process which ends later than the natural end time.
A length quality which is equal to the length of any straight line segment that passes through the center of a circle and whose endpoints are on the circular boundary.
A mating type that indicates whether the F plasmid has integrated into the chromosome.
A biological sex quality inhering in an individual whose sex is unknown.
A biological sex quality inhering in a population of multiple sexes.
For example a mixture of females and male or males and hermaphrodites.
A composition quality inhering in an bearer by virtue of the bearer's homogeneity of a biomaterial.
A biological sex quality inhering in an organism or a population with both male and female sexual organs in one individual.
A S. cerevisiae mating type cells that secrete a pheromone that in alpha haploids stimulates processes that lead to mating.
A S. pombe mating type determined by the gene configuration on the mat1 locus.
A S. cerevisiae mating type cells that secrete a pheromone that stimulates a haploids.
A S. pombe mating type determined by the mat1-Mc and mat1-Mi on the mat1 locus.
A S. pombe mating type determined by the mat1-Pc and mat1-Pi on the mat1 locus.
A bacterial mating type indicating the presence of F plasmid in a bacterial cell.
A bacterial mating type indicating the absence of F plasmid in a bacterial cell.
A mating type that indicates that the F plasmid has integrated into the chromosome.
A physical quality inhering in a bearer by virtue of the rate of change of the bearer's angular velocity.
A density quality which inheres in a bearer by virtue of some influence exerted by the bearer's mass on a given area.
A density quality which is equal to the mass exerting an influence on a one-dimensional object.
A density quality which inheres in a bearer by virtue of some influence exerted by the bearer's mass on a given volume.
A optical quality inhering in a bearer by virtue of the bearer's exhibiting low opacity.
A shape quality that obtains by virtue of the bearer having inward facing edges; having a surface or boundary that curves or bulges outward, as the exterior of a sphere.
A shape quality inhering in a cell by virtue of the bearer's ability to take on two or more different shapes during its life cycle.
A convex 3-D shape quality inhering in a bearer by virtue of the bearer's being shaped like a cushion or has a marked convex cushion-like form.
A quality inhering in a bearer by virtue of the bearer's having a knob or knoblike protuberance.
A surface feature shape quality inhering in a bearer by virtue of the bearer's having many wrinkles or creases on the surface.
A shape quality inhering in a bearer by virtue of the bearer's having thin filamentous extensions at its edge.
A texture quality inhering in a bearer by virtue of the bearer's being covered with warts or projections that resemble warts resulting in a hard rough surface.
A structural quality inhering in a bearer by virtue of the bearer's disposition to being easily damaged or destroyed.
A quality inhering in a bearer by virtue of the bearer's having root like extensions radiating from its center.
A surface feature shape quality inhering in a bearer by virtue of the bearer's having spines, thorns or similar thin projections on its surface.
A shape quality inhering in a bearer by virtue of the bearer's being small and resembling a point.
A surface feature shape quality inhering in a bearer by virtue of the bearer's having deeply undulating edges forming lobes.
A surface feature shape quality inhering in a bearer by virtue of the bearer's having an irregularly toothed edge.
A shape quality inhering in a colony by virtue of the bearer's appearing above the medium surface with terraced edges.
A coating quality which is sticky or clammy.
A composition quality inhering in an bearer by virtue of the bearer's consistency of mucus.
A physical quality that inheres in propagating wave (light or sound) virtue of the bearer's change in direction when passing from one medium to another.
A reflectivity quality inhering in a bearer by virtue of the bearer's reflecting lots of light.
A cellular quality inhering in a bearer by virtue of the bearer's number of homologous sets of chromosomes in the nucleus or primary chromosome-containing compartment of the cell, each set essentially coding for all the biological traits of the organism.
A ploidy quality inhering in a bearer by virtue of the bearer's containing a single set of homologous chromosomes.
A ploidy quality inhering in a bearer by virtue of the bearer's containing a single set of unique homologous chromosomes.
A ploidy quality inhering in a bearer by virtue of the bearer's containing more than two homologous sets of chromosomes.
A polyploidy quality inhering in a bearer by virtue of the bearer's containing chromosomes derived from a single species.
A polyploidy quality inhering in a bearer by virtue of the bearer's containing chromosomes derived from different species.
A polyploidy quality inhering in a bearer by virtue of the bearer's having an ancient polyploid ancestor.
A polyploidy quality inhering in a bearer by virtue of the bearer's containing three homologous sets of chromosomes.
A polyploidy quality inhering in a bearer by virtue of the bearer's containing four homologous sets of chromosomes.
A polyploidy quality inhering in a bearer by virtue of the bearer's containing five homologous sets of chromosomes.
A polyploidy quality inhering in a bearer by virtue of the bearer's containing six homologous sets of chromosomes.
A ploidy quality inhering in a bearer by virtue of the bearer's containing a non-integral multiple of the monoploid number, due to extra or missing chromosomes.
An aneuploidy quality inhering in a bearer by virtue of the bearer's containing only one chromosome from a pair in a cell's nucleus.
An aneuploidy quality inhering in a bearer by virtue of the bearer's containing only two chromosome from a pair in a cell's nucleus.
For diploid organisms, such as humans, it is the normal condition, whilst for organisms that are normally triploid or above, disomy is an aneuploidy.
A disomy quality inhering in a bearer by virtue of the bearer's containing two copies of the chromosome from one of the parents (with no contribution from the other parent).
An aneuploidy quality inhering in a bearer by virtue of the bearer's containing three, instead of two, chromosomes of a particular numbered type in an organism.
A trisomy quality inhering in a bearer when part of the bearer's extra chromosome is attached to one of the other chromosomes, or if one of the bearer's chromosomes has two copies of part of its chromosome.
A trisomy quality inhering in a bearer by virtue of the bearer's having extra chromosomal material in only some of it's cells.
A polyploidy quality inhering in a bearer by virtue of the bearer's chromosome number being increased by endomitosis and for which the degree of ploidy is proportional to the number of times that endomitosis has taken place.
A ploidy quality inhering in a bearer by virtue of the bearer's containing an integral multiple of the monoploid number, possibly excluding the sex-determining chromosomes.
A ploidy quality inhering in a bearer by virtue of the bearer's having two copies (homologs) of each chromosome, usually one from the mother and one from the father.
The exact number may be one or two different from the 2n number and still be classified as diploidy (although with aneuploidy). Nearly all mammals are diploid organisms, although all individuals have some small fraction of cells that are polyploidy.
A diploidy quality inhering in a bearer in by virtue of belonging in a species whose one of the sexes has haploid cells and the other has diploid cells.
A monadic quality of continuant that exists at the cellular level of organisation.
A cellular quality that arises by virtue of whether the bearer's disposition to differentiate into one or more mature cell types.
A cellular quality inhering in a bearer by virtue of the bearer's having the ability to go through numerous cycles of cell division while maintaining the undifferentiated state.
A cellular potency that is the capacity to produce differentiated cell types of all three primary germ layers and extraembryonic cell types.
A cellular potency that is the capacity to produce only one differentiated cell type.
Unipotent cells have the quality of self-renewal which distinguishes them from non-stem cells.
A cellular potency that is the capacity to form multiple differentiated cell types of a specific lineage and lack self renewing capacity.
Less potent than multipotent, often thought of as precursor or progenitor cell status.
A cellular potency that is the capacity to form multiple differentiated cell types.
A cellular potency that is the capacity to produce differentiated cell types of all three primary germ layers but not extraembryonic cell types.
A cellular quality inhering in a bearer by virtue of bearer's number of nuclei.
A nucleate quality inhering in a bearer by virtue of the bearer's having no nucleus.
A nucleate quality inhering in a bearer by virtue of the bearer's having two nuclei.
A nucleate quality inhering in a bearer by virtue of the bearer's having one nucleus.
A cellular quality inhering in a bearer by virtue of the bearer's having one or more cilia as a part.
A shape quality inhering in a bearer by virtue of the bearer's resembling a long tapered rod.
A shape quality inhering in a bearer by virtue of the bearer's being marked by narrow lines or grooves, usually parallel.
A structural quality inhering in a bearer by virtue of the bearer's having distinct structure.
A structural quality inhering in a bearer by virtue of the bearer's lacking distinct structure.
A physical quality inhering in a bearer by virtue of the rate of the bearer's angular movement about an axis; the angle rotated in a given time.
A physical quality inhering in a catalyst by virtue of the amount of the catalyst's action.
A quality inhering in a population by virtue of the proportion of its members that are ill at a given time.
A duration which has regular start and/or end times.
A duration quality of a process inhering in a bearer by virtue of the bearer's duration which has irregular start and/or end times.
A behavioral quality inhering in a bearer by virtue of the bearer's being deficient in alertness or activity.
A shape quality inhering in a bearer by virtue of the bearer's terminating in a point or edge.
A physical quality inhering in a bearer by virtue of the bearer's disposition to rise or float in a fluid medium such as water or air.
A viability quality inhering in a bearer by virtue of the bearer's condition before death.
A viability quality inhering in a bearer by virtue of the cessation of the bearer's life.
A reflectivity quality inhering in the bearer by virtue of the bearer's ability to refract light.
A color hue with very low wavelength of that portion of the visible spectrum lying between reddish blue or bluish purple, evoked in the human observer by radiant energy with wavelengths of approximately 420 to 380 nanometers.
A color hue consisting of red hue and yellow hue and high brightness.
A color consisting of purple and brown hue.
A concentration quality inhering in compound by virtue of the bearer's tendency to act as a hydron donor.
A concentration quality inhering in a medium by virtue of the bearer's tendency to hydronate a specific reference base.
An medium acidity quality inhering in a solution by virtue of the bearer's a high concentration of H+ ions.
An medium acidity quality inhering in a solution by virtue of the bearer's a low concentration of H+ ions.
An emergent molecular quality that arises by virtue of the bearer's disposition to exhibit molecular attraction to another entity in contact.
The definition is general enough to cover adhesion arising from different kinds of chemical bonding/forces, although for PATO this term will most commonly used for cellular adhesion. See also GO:0031589 "cell-substrate adhesion".
A quality inhering in a bearer by virtue of the bearer's decomposition into component parts.
A quality of a single process which describes the growth of an organism, structure, or group of organisms.
An organismal quality inhering in a bearer by virtue of the bearer's ability to produce new life or offspring.
A structural quality inhering in a bearer by virtue of the bearer's having connection or association with another entity.
An attachment quality inhering in a flower by virtue of the bearer's lacking a stalk, as in flowers or leaves that grow directly from the stem.
A attachment quality inhering in a bearer by virtue of the bearer's inability to move about.
A attachment quality inhering in a bearer by virtue of the bearer's having or being supported by a pedicel or pedicle.
A contractile quality inhering in a bearer by virtue of the bearer's elastic tension that facilitate response to stimuli.
TODO: we need a clearer differentium between this and contractility - or merge?
A cellular adhesivity quality inhering in a molecule in one cell by virtue of the bearer's attachment to an identical molecule in an adjacent cell.
A cellular adhesivity quality inhering in a molecule in one cell by virtue of the bearer's attachment to an nonidentical molecule in an adjacent cell.
A structural quality inhering in a bearer by virtue of whether the bearer includes all its components.
A structural quality inhering in a bearer by virtue of the bearer's components no longer being in a single contiguous unit.
A wholeness quality inhering in a bearer by virtue of the bearer's being taken apart into its constituent parts.
A wholeness quality inhering in a bearer by virtue of the bearer's including all its components.
A composition quality inhering in an bearer by virtue of the bearer's being encrusted or impregnated with calcium carbonate (CHEBI:3311).
A composition quality inhering in an bearer by virtue of the bearer's being hardened by the deposition of calcium into bone.
A composition quality inhering in an bearer by virtue of the bearer's cartilage quantities.
Cartilage is a type of dense connective tissue. It is composed of specialized cells called chondrocytes (CL:0000138) that produce a large amount of extracellular matrix composed of collagen fibers, abundant ground substance rich in proteoglycan, and elastin fibers.
A structural quality which is held by a bearer when the latter exhibits an excessive accumulation of extracellular fluid.
An extended swelling in plant organs caused primarily by an excessive accumulation of water.
An attachment quality inhering in a bearer by virtue of the bearer's lacking connection or association with another entity.
A sensitivity quality inhering in a bearer by virtue of the bearer's dependence on oxygen.
A quality inhering in a bearer by virtue of the bearer's dependence on oxygen.
A quality inhering in a bearer by virtue of the bearer's independence on oxygen.
A quality of a process inhering in bearer by virtue of the bearer's disposition to respond to stimulation.
A sensitivity of a process quality inhering in a bearer by virtue of the bearer's unfolding in a location with or without oxygen.
A sensitivity of a process inhering in a biological process by virtue of the process unfolding in a location with oxygen.
A sensitivity of a process inhering in a biological process by virtue of the process unfolding in a location without oxygen.
A physical quality inhering in a liquid by virtue of the bearer's ability to attraction of molecules at its surface as a result of unbalanced molecular cohesive forces.
A quality inhering in a cell's plasma membrane by virtue of the electrical potential difference across it.
A quality inhering in a cell's plasma membrane by virtue of a brief fluctuation in the bearer's potential caused by the rapid opening and closing of voltage-gated ion channels.
A quality that is equal to the potential energy per unit charge associated with a static (time-invariant) electric field, also called the electrostatic potential.
A malformed quality inhering in a bearer by virtue of the bearer's all-encompassing, grotesque morphological defects.
A curvature quality inhering in a bearer by virtue of the bearer's being curved towards the front of an organism.
A curvature quality inhering in a bearer by virtue of the bearer's being curved towards the part of the body from which the tail arises.
A curvature quality inhering in a bearer by virtue of the bearer's being curved towards the back or upper surface of an organism.
A curvature quality inhering in a bearer by virtue of the bearer's being curved towards the abdomen of an organism.
A quality inhering in a bearer by virtue of the bearer's magnitude in proportion to the magnitude of another entity.
Examples: height to weight; brain size to body size; root to shoot ratio; urinary sodium to potassium ratio. waist-hip ratio.
A quality inhering in a bearer by virtue of the bearer's being present in two copies.
An oriented quality inhering in a bearer by virtue of the bearer's axis being positioned forward.
A positional quality inhering in a bearer by virtue of the bearer's being drawn in or pulled back from any given point.
A structural quality inhering in a bearer by virtue of the bearer's being broken down; caved in.
A structural quality inhering in a bearer by virtue of the bearer's resembling a sponge in elasticity, absorbency, or porousness.
A shape quality inhering in a bearer by virtue of the bearer's having an oblique or slanted direction.
A quality inhering in a bearer by virtue of the bearer's standing out or projecting beyond a surface or line.
Absence of an organ, tissue or cell due to failure to develop from a primordium or precursor cell.
With aplasia, the primordium or precursor develops, but does not proceed in its development to a mature structure
A quality of a process which occurs near to or not long before the present.
A structural quality inhering in a bearer by virtue of the bearer's being thicker or more closely packed together; pressed tightly together.
An age quality that exists by virtue of the time (years and months) that the bearer has existed.
A time quality inhering in a bearer by virtue of the bearer's growing old; aging.
A cellular quality inhering in a cell by virtue of whether the bearer exhibits the ability to move spontaneously.
Term should be obsoleted and the GO term cellular motility should be used instead.
A growth quality of a process inhering in an organism, structure, or group of organisms by virtue of the bearer's reduced or increased growth.
A paedomorphic growth quality which is due to a reduced rate.
The rate or speed of the change in size of an individual entity or change in number of a population.
This term will be obsoleted; Use GO:growth and PATO:rate.
A concave quality inhering in a bearer by virtue of the bearer's shape being a V-shaped cut.
A reproductive quality inhering in the young of an animal by virtue of the bearer's being cared for at one time.
A reproductive quality inhering in the young of an animal by virtue of the bearer's disposition to survive and develop normally.
A spheroid quality inhering in a bearer by virtue of the bearer's resembling a ball (a sphere whose equatorial diameter is equal to the polar diameter).
A shape quality inhering in a bearer by virtue of the bearer's being gradually narrower or thinner toward one end.
A quality inhering in a bearer by virtue of the bearer's lacking complete growth, differentiation, or development.
A monadic quality of continuant inhering in a bearer by virtue of the bearer's being intricate and compounded.
A complexity quality in a bearer by virtue of the bearer's having few parts or being complicated or compound.
A complexity quality inhering in a bearer by virtue of the bearer's being intricate and compounded.
A structural quality inhering in a bearer by virtue of the bearer's not being in contact with another entity, or of no longer being connected or joined with another entity.
A structural quality inhering in a bearer by virtue of the bearer's separation of normally joined parts, such as the separation of adjacent bones without fracture or of certain abdominal muscles during pregnancy.
A quality of a single process inhering in a bearer by virtue of the bearer's being interrupted of its normal course.
A quality of a single physical entity that arises by virtue of whether the bearer exhibits the ability to perform a regular function(s).
A functionality quality held by the bearer when the latter is able to perform a regular function(s).
A disfunctional quality held by the bearer when the latter is unable to perform a regular function(s).
A pattern inhering in a surface by virtue of the bearer's being marked by the presence of dots, punctures, points or pits.
A structural quality inhering in a bearer by virtue of the bearer's lacking some outer layer.
A color quality inhering in a bearer by virtue of the bearer's being uneven in color.
An optical quality where light rays originating from a point on the object converge.
An optical quality inhering in a bearer by virtue of the bearer's having focus.
An optical quality inhering in a bearer by virtue of the bearer's lacking focus.
A quality inhering in a bearer by virtue of vibration, as perceived by the sense of hearing.
The frequency of transmitted vibrations.
A physical quality inhering in a sound wave by virtue of the maximum magnitude (value without regard to sign) of its disturbance.
A physical quality inhering in sound by virtue of the bearer's travelling speed in a given medium under specified conditions.
A physical quality which is equal to the quotient of the speed of a sound wave divided by its wavelength.
A sound frequency in the range of 0-20 Hz.
A sound frequency in the range of 20 to 20.000 Hz.
A sound frequency in the range of 20 000 + Hz.
A sound amplitude which is relatively low.
A sound amplitude which is relatively high.
A spatiotemporal quality inhering in a cell.
A quality of a single process inhering in a bearer by virtue of the bearer's behavior.
A cellular quality that exists by virtue of the disposition of the cell to adhere to other cells and molecules, through the emergent action of the molecular parts of the cell surface.
A color pattern inhering in a bearer by virtue of the bearer's having one hue.
A color pattern inhering in a bearer by virtue of bearer's having two or more hues or degrees of saturation.
A color pattern inhering in a bearer by virtue of bearer's having 3 or more hues or degrees of saturations.
A color pattern inhering in a bearer by virtue of bearer's being marked with small spots, patches, or specks of hue or degree of saturation differing from that of the background.
A molecular quality that inheres in a molecular entity by virtue of the bearer's disposition to dissolve in a liquid.
A solubility quality inhering in a substance by virtue of the bearer's disposition to dissolve in a liquid.
A solubility quality inhering in a substance by virtue of the bearer's inability of a substance to dissolve in a liquid.
A compositional quality inhering in an bearer by virtue of the bearer's quantities or relative ratios of amylose of the inhering entity.
An amylose composition quality inhering in an bearer by virtue of the bearer's having negligible or no amylose content.
An amylose composition quality inhering in an bearer by virtue of the bearer's having high amount of amylose content.
A phase which starts later than natural start point.
A physical quality inhering in a bearer by virtue of the bearer's disposition to being turned, bowed, or twisted without breaking.
A physical quality inhering in a bearer by virtue of the bearer's ability of being turned, bowed, or twisted without breaking.
A physical quality inhering in a bearer by virtue of the bearer's inability of being turned, bowed, or twisted without breaking.
A physical quality inhering in a bearer by virtue of the bearer's exhibiting the physical characteristics of an entity characterized by particles arranged such that their shape and volume are relatively stable.
A physical quality inhering in a bearer by virtue of the bearer's exhibiting the physical characteristics of an entity consisting of particles that have neither a defined volume nor defined shape.
A physical quality inhering in an entity exhibiting the physical characteristics of an amorphous (non-crystalline) form of matter between a gas and a solid that has a definite volume, but no definite shape.
A sensitivity toward an external stimulus which is higher than normal/average.
A sensitivity toward an external stimulus which is lower than normal/average.
A sensitivity of a process which is higher than normal or average.
A sensitivity of a process which is lower than normal or average.
A sensitivity of occurrent to oxygen which is higher than normal or average.
increased sensitivity of a process to oxygen
A sensitivity of a process to oxygen which is lower than normal or average.
decreased sensitivity of a process to oxygen
The number of parts of a particular type that the bearer entity has. This is a relational quality, and thus holds between two entities: the bearer of the quality, and the type of parts.
extra or missing physical or functional parts
A quality of a process inhering in a bearer by virtue of the bearer's lacking a processual part as specified by the additional entity.
A functionality quality which is held by the bearer when the latter is able to perform additional or different function(s).
A quality of a process inhering in a bearer by virtue of the bearer's having additional processual parts.
A mass which is lower than normal or average.
A mass which is higher than normal or average.
A quality of a process inhering in a bearer by virtue of the bearer's processual parts.
A spatial pattern inhering in a bearer by virtue of the bearer's being spread out or scattered about or divided up.
A spatial pattern inhering in a bearer by virtue of the bearer's not being spread out or scattered about or divided up.
A quality of a process inhering in a bearer by virtue of the bearer's having fewer processual parts.
A size quality inhering in a bearer by virtue of the bearer's being made wider or larger in all dimensions.
A symmetry quality inhering in a bearer by virtue of the bearer's having equal dimensions or measurements.
A physical quality inhering in a bearer by virtue of the bearer's motion characteristic.
A permeability which is relatively high.
A physical quality that is the ability to contract or shrink.
A contractility which is relatively high.
A contractility which is relatively low.
A spatial quality inhering in an inactive muscle or muscle fibers by virtue of the bearer's exhibiting gradual lengthening.
GO has now relevant relation terms which should be used instead.
A physical quality inhering in a bearer by virtue of the bearer's disposition to transmit of an entity through a medium.
Examples could be heat or electricity or sound.
A variability quality inhering in a bearer by virtue of whether the bearer exhibits rate variation or change.
A variability of rate which is relatively high.
A variability of rate which is relatively low.
Obsoleted because it used to be a child of behavioral quality, which really meant increased magnitude of a given behavior. Now this can be done by using increased magnitude with another quality.
A structural quality inhering in a bearer by virtue of the bearer's coinciding spatially, partially or wholly with another entity.
A surface shape quality inhering in a bearer by virtue of the bearer's exhibiting a degree of bending.
A concave quality inhering in a bearer by virtue of the bearer's forming or resembling an arch.
A 1-D extent quality inhering in a bearer by virtue of the bearer's downward or backward or inward dimension.
A depth quality which is relatively high.
An oriented quality inhering in a bearer by virtue of the bearer's being turned outward in placement.
A quality inhering in a bearer by virtue of the bearer's extending out above or beyond a surface or boundary.
An oriented quality inhering in a bearer by virtue of the bearer's being relocated around an axis.
A rotation quality inhering in a bearer by virtue of being rotated towards the rear of organism.
A rotation quality inhering in a bearer by virtue of being rotated towards the front of an organism.
A size quality inhering in a bearer by virtue of the bearer's being abnormally expanded or increased in size.
A spatial pattern inhering in a bearer by virtue of the bearer's being in disarray; extremely disorderly.
A tangled quality inhering in a bearer by virtue of the bearer's being not possible to unravel.
A spatial pattern inhering in a bearer by virtue of the bearer's being marked by, consisting of, or diversified with patches.
A spatial pattern inhering in a bearer by virtue of the bearer's being scattered; spread irregularly, and at a distance from each other.
A variability quality inhering in a bearer by virtue of whether the bearer exhibits color variation or change.
A variability of color which is relatively high.
A variability of color which is relatively low.
A variability quality inhering in a bearer by virtue of the bearer's lacking or not exhibiting variation of color.
A variability quality inhering in a bearer by virtue of the bearer's having or exhibiting variation of colour.
A morphological quality inhering in a bearer by virtue of the bearer's being distorted in form.
A structural quality inhering in a cell or blood vessel or capillary by virtue of the bearer's being in a rigid state of fullness resulting from pressure of the contents against the wall or membrane.
A size quality inhering in a bearer by virtue of a part or parts of the bearer's being decreased in size due to reduction in tissue mass through wasting.
A functionality quality held by the bearer when the latter exhibits decreased ability to perform a regular function(s).
A functional quality held by the bearer when the latter exhibits increased ability to perform a regular function(s).
A structural quality inhering in a bearer by virtue of whether the bearer has enough functionality.
This term and children should probably be obsoleted.
A wholeness quality inhering in a bearer by virtue of the bearer's has enough functionality.
A wholeness quality inhering in a bearer by virtue of the bearer's lacks enough functionality.
A spatial pattern inhering in a bearer by virtue of the bearer's being gathered or tending to gather into a mass or whole.
A positional quality inhering in a bearer by virtue of the bearer's being distributed or spread over a considerable extent.
A spatial quality inhering in a bearer by virtue of the bearer's being located toward the front of an organism relative to another entity.
A spatial quality inhering in a bearer by virtue of the bearer's being located toward the rear of an organism relative to another entity.
A quality of a single physical entity inhering in a bearer by virtue of whether the bearer is essential or indispensable.
A necessity quality (continuant) inhering in a bearer by virtue of the bearer's being essential or indispensable.
A necessity quality (continuant) inhering in a bearer by virtue of the bearer's being non-essential or dispensable.
A quality of single process inhering in a bearer by virtue of whether the bearer is essential or indispensable.
A necessity quality inhering in a process by virtue of the bearer's being essential or indispensable.
A necessity quality inhering in a process by virtue of the bearer's being non-essential or dispensable.
A size quality inhering in a bearer by virtue of the bearer's having a short, stocky build.
A quality inhering into a bearer by virtue of the bearer's extending out above or beyond its surface or boundary into the surface or boundary of another entity.
A quality inhering into a bearer by virtue of the bearer's extending out above or beyond its surface or boundary and outwards in relation to the physical space occupied by another entity.
An 1-D extent quality which is equal to the length of the closed curve of a circle.
A curvature quality inhering in a bearer by virtue of the bearer's being curved towards the side.
A resistance to a stimulus which is relatively high.
A resistance to a stimulus which is relatively low.
A spatial quality inhering in a bearer by virtue of the bearer's spatial positioning with respect to an additional entity.
An alignment quality inhering in a bearer by virtue of the bearer's being in a proper spatial positioning with respect to an additional entity.
An alignment quality inhering in a bearer by virtue of the bearer's being in a improper spatial positioning with respect to an additional entity.
A concentration quality inhering in a bearer by virtue of the bearer's amount of osmoles of solute per liter of solution.
A rotation quality inhering in a bearer by virtue of being rotated towards the back or upper surface of an organism.
A rotation quality inhering in a bearer by virtue of being rotated towards the abdomen of an organism.
An action potential which is relatively low.
An action potential which is relatively high.
A structural quality inhering in a bearer by virtue of the bearer's disposition to being damaged or destroyed.
A spatial pattern inhering in a bearer by virtue of the bearer's being located near a surface.
An attachment quality inhering in a bearer by virtue of the bearer's connection or association with another entity.
A structural quality inhering in a bearer by virtue of the bearer's being in close proximity and physically interacting with another entity.
A susceptibility toward an external stimulus which is higher than normal/average.
A susceptibility toward an external stimulus which is lower than normal/average.
A distribution which is relatively high.
Structure quality that is the presence of at least one sac-like closed membranous structure containing one or more liquid or solid organism substances.
A concentration quality inhering in a bearer by virtue of the bearer's catalytic activity divided by the volume of the system.
An efficiency quality inhering in a bearer by virtue of the bearer's lacking efficiency.
An efficiency quality inhering in a bearer by virtue of the bearer's having efficiency.
A volume quality inhering in a mass of substance by virtue of the amount of 3-dimensional space it occupies.
A volume quality inhering in a homogeneous substance containing 6.02 x 1023 atoms or molecules by virtue of the amount of 3-dimensional space it occupies.
A physical quality that inheres in a homogeneous substance containing 6.02 x 1023 atoms or molecules.
A physical quality inhering in a bearer by virtue of the bearer's disposition to exert an attractive or repulsive force on other entities.
A magnetic quality inhering in a bearer by virtue of the bearer's ability to exert magnitism.
A magnetic quality inhering in a bearer by virtue of the bearer's inability to exert magnitism.
A positional quality inhering in a bearer by virtue of the bearer's vertical distance of a point above or below a reference surface.
A contractility quality inhering in a bearer by virtue of the bearer's ability of contracting or being contracted.
This refers to the disposition of the bearer.
A contractility quality inhering in a bearer by virtue of the bearer's inability of contracting or being contracted.
A photosensitivity which is relatively low.
A photosensitivity which is relatively high.
A sleep pattern which has regular start and/or end times.
A sleep pattern which has irregular start and/or end times.
A quality inhering in a bearer by virtue of the bearer's exhibiting complete growth, differentiation, or development.
A color consisting of violet hue and high saturation.
A color consisting of violet hue and low saturation.
A color consisting of violet hue and high brightness.
A color consisting of violet hue and low brightness.
A behavioral quality inhering in a bearer by virtue of the bearer's disposition to lack activity.
A behavioral quality of a process inhering in a bearer by virtue of the bearer's exhibiting marked activity.
A size quality inhering in an bearer by virtue of the bearer's extension in one dimension.
A size quality inhering in an bearer by virtue of the bearer's extension in two dimensions.
A size quality inhering in an bearer by virtue of the bearer's extension in three dimensions.
An 1-D extent quality inhering in two-dimensional bearer by virtue of being equal to the distance around it.
A structural quality inhering in a bearer by virtue of the bearer's ability to withstand great strain without tearing or breaking.
A radiation emitting quality which obtains by the intensity of the bearer emitted radiation.
A quality that exists by virtue of the luminous intensity per unit area projected in a given direction.
A behavioral quality which holds by virtue of whether the bearer exhibits the ability to receive another agentitive entity.
A behavioral quality which holds by virtue of extent of the receptiveness of a female to male advances.
A behavioral quality which holds by virtue of extent of the receptiveness of a male to female advances.
A female receptivity which is relatively high.
A female receptivity which is relatively low.
A male receptivity which is relatively high.
A male receptivity which is relatively low.
A quality inhering in a bearer by virtue of the bearer's prevailing tendency, mood, or inclination.
A disposition inhering in a multi-cellular organism.
An organismal quality inhering in a bearer by virtue of the bearer's disposition to lose an entity by natural process.
A quality inhering in a bearer by virtue of the bearer's disposition to shed body parts.
A quality inhering in a plant by virtue of the bearer's disposition to shed foliage.
A quality inhering in a plant by virtue of the bearer's disposition to not shed any body part.
A quality inhering in a plant by virtue of the bearer's disposition to retain foliage.
A quality inhering in a plant by virtue of the bearer's disposition to being between evergeen and deciduous.
A physical quality inhering in a bearer by virtue of the bearer's parts having the arrangement which exhibits characteristics of liquids.
A physical quality inhering in a bearer by virtue of the bearer's parts having the arrangement which exhibits characteristics of solids.
A physical quality inhering in a bearer by virtue of the bearer's parts having the arrangement which exhibits characteristics of gases.
A structural quality inhering in a bearer by virtue of the bearer's lacking physically interaction with another entity.
A quality of radiation that reflects the fluence spectrum of charged and neutral particles within the material or medium where dose is being deposited.
Radiation quality is often expressed in terms of the linear energy transfer of the ionising particles that deliver the absorbed dose, but this is an over simplification.
A radiation quality inhering in a radioactive substance by virtue of its transformation (disintegration) rate.
A radiation quality inhering in bearer by virtue of the bearer's exhibiting or being caused by radioactivity.
A radioactivity which is relatively low.
A radioactivity which is relatively high.
A quality of a substance inhering in a bearer by virtue of it being currently or previously exposed to electromagnetic radiation,
This may refer to incident external irradiation or internal radiation from an ingested or otherwise internal source.
OBSOLETE A radiation exposure quality inhering in a substance by virtue of the radiation energy "deposited" in a kilogram of a substance.
OBSOLETE A radiation exposure quality inhering in a tissue by virtue of the relation between the absorbed dose to the effective biological damage of the radiation to that tissue.
See: https://github.com/pato-ontology/pato/issues/485
OBSOLETE A radiation exposure quality inhering in an organ by virtue of the multiplication of an equivalent dose to that organ multiplied by the tissue weighting factor for that organ.
A shape quality in which a portion of the outermost boundary of an entity folds in space such that a portion that was originally convex is now concave.
A heterochronic growth quality inhering in an organism, structure, or group of organisms by virtue of the bearer's reduced growth.
A paedomorphic growth quality which is due to a delayed onset.
A paedomorphic growth quality which is due to an earlier offset.
A heterochronic growth quality inhering in an organism, structure, or group of organisms by virtue of the bearer's increased growth.
A peramorphic growth quality which is due to an increased rate.
A peramorphic growth quality which is due to an earlier onset.
A peramorphic growth quality which is due to a delayed offset.
A conductivity quality inhering in a bearer by virtue of the bearer's disposition to spontaneous transfer of thermal energy from a region of higher temperature to a region of lower temperature.
A conductivity quality inhering in a bearer by virtue of the bearer's ability to convey electricity.
A conductivity quality inhering in motor and sensory nerves by virtue of the bearer's ability to convey electricity.
A composition quality inhering in a bearer by virtue of the bearer's containing granules.
An age which is high relative to the normal or average.
An age which is low relative to the normal or average.
A cellular quality inhering in a cell by virtue of its anisotropic intracellular organization.
A viability quality inhering in a bearer or a population by virtue of some of it's members' inability to survive to reproduce.
A positional quality inhering in a bearer by virtue of the bearer's location of features or characteristics along an axis.
A viability quality inhering in a population by virtue of some of it's members' ability to survive.
A spatial quality inhering in a bearer by virtue of the bearer's being extended on all sides of another entity simultaneously.
Nedd to add reciprocal of relationship to 'surrounded by' PATO:0005016.
A quality inhering in a bearer by virtue of the bearer's having only one phase or stage.
A quality inhering in a bearer by virtue of the bearer's having or existing in many phases.
A positional quality inhering in a bearer by virtue of the bearer's location of features or characteristics along the dorsal-ventral axis.
A size quality inhering in a bearer by virtue of the bearer's being abnormally developed, usually due to malnutrition.
A thickness quality which lacks pattern.
A branched quality inhering in a bearer by virtue of the bearer's being divided into two branches.
A curvature quality inhering in a bearer by virtue of the bearer's being curved outward.
TODO: obsolete, definition too ambiguous.
A shape quality inhering in a bearer by virtue of the bearer's being divided or broken up into parts or divisions.
A curvature quality inhering in a bearer by virtue of the bearer's being curved around an axis.
A density which is higher relative to the normal or average.
A curvature quality inhering in a bearer by virtue of the bearer's having a shape resembling a dome.
A density which is lower relative to the normal or average.
A spatial pattern inhering in a bearer by virtue of the bearer's being confined or restricted to multiple locations.
A spatial quality inhering in a bearer by virtue of the bearer's being located on left side of from the a another entity.
A spatial quality inhering in a bearer by virtue of the bearer's being located on right side of a another entity.
A shape quality inhering in a bearer by virtue of the bearer's being wound in a continuous series of loops.
A shape quality inhering in a bearer by virtue of the bearer's having multiple angles in its length.
A shape quality inhering in a bearer by virtue of the bearer's exhibiting disturbance of its smoothness or regularity.
A composition quality inhering in an bearer by virtue of the quantities or relative ratios of water of the inhering entity.
A composition quality inhering in an bearer by virtue of the reduction in amount of water the bearer contains.
A pattern quality inhering in a bearer by virtue of the bearer's not being compact or dense in arrangement.
A photosensitivity quality inhering in a bearer by virtue of the bearer's disposition to being susceptible to damage by light.
A texture quality inhering in a bearer by virtue of the bearer's being covered or partially covered with scales.
A texture quality inhering in a bearer by virtue of the bearer's formed or tending to form flakes or thin, crisp fragments.
A sensitivity quality inhering in a bearer by virtue of the bearer's exposure to radiation.
A sensitivity to irradiation which is relatively low.
A sensitivity to irradiation which is relatively high.
A pattern quality inhering in a bearer by virtue of the bearer's being compact or dense in arrangement.
A grooved texture quality inhering in a bearer by virtue of the bearer's being marked by one or more creases in a normally smooth surface.
A structural quality inhering in a bearer by virtue of the bearer's lack elastic tension that facilitate response to stimuli.
A structural quality inhering in a bearer by virtue of the bearer's impaired elastic tension that facilitate response to stimuli.
A strength quality inhering in a bearer by virtue of the bearer's disposition to lose strength.
A fatigability which is relatively high.
A quality of a single process inhering in a bearer by virtue of the bearer's increasing over time.
A morphological quality inhering in a bearer by virtue of the bearer's absence or closure of a normal body orifice or tubular passage.
A structural quality inhering in a bearer by virtue of the bearer's having no opening.
A quality inhering in a bearer by virtue of whether the bearer's being covered by a liquid.
A wetness quality inhering in a bearer by virtue of the bearer's being covered by a liquid.
A wetness quality inhering in a bearer by virtue of the bearer's not being covered by a liquid.
A wetness quality that is relatively high.
A wetness quality that is relatively low.
A biological sex quality inhering in an individual or a population by virtue of having internal reproductive organs of one sex and external sexual characteristics of the other sex.
A biological sex quality inhering in an individual or a population by virtue of having internal reproductive organs of male and external sexual characteristics of female.
A biological sex quality inhering in an individual or a population by virtue of having internal reproductive organs of female and external sexual characteristics of male.
A female fertility which is relatively low.
A female fertility which is relatively high.
A male fertility which is relatively high.
A male fertility which is relatively low.
A structural quality inhering in a bearer with some kind of aperture or opening that is blocked or clogged.
An intensity which is characterized by temporary abatement in severity.
A concentration quality inhering in a bearer by virtue of the bearer's containing acid (hydrogen ions).
A rhythm quality inhering in a bearer by virtue of the bearer's lacking rhythm lacking pattern.
A structural quality inhering in a bearer by virtue of the bearer's being entwined and difficult to unravel.
A structural quality inhering in a bearer by virtue of the bearer's being drawn together, compressed or squeezed physically.
A curvature quality inhering in a bearer by virtue of the bearer's being curved asymmetrically.
A texture quality inhering in a bearer by virtue of a portion of the bearer's surface being scraped away.
A structural quality inhering in a bearer by virtue of the bearer's being fibrous tissue that replaces normal tissue destroyed by injury or disease.
A structure quality inhering in a bearer by virtue of the bearer's exhibiting transient abnormal enlargement, not due to cell proliferation.
A positional quality inhering in a bearer by virtue of the bearer's being out of its usual or proper place, or position due to it being physically moved from the normal location.
A structural quality which is held by a bearer when the latter exhibits an excessive accumulation of cerebral spinal fluid.
A spatial pattern inhering in a bearer by virtue of the bearer's being situated at right angles to the horizon.
A positional quality inhering in a bearer by virtue of the bearer's being in the plane of the horizon.
An oriented quality inhering in a bearer by virtue of the bearer's being turned inward upon itself.
A shape quality in a bearer by virtue of the bearer's curving inward.
A functionality quality inhering in a bearer by virtue of being not completely paralysed.
A coordination which is relatively high.
A structural quality inhering in a bearer by virtue of the bearer's forming a bundle of aligned anatomical fibers, as of muscle or nerve.
A fertility quality inhering in a bearer by virtue of the bearer's disposition to make its offspring sterile.
A duration quality of a process inhering in a bearer by virtue of the bearer's having slow progressive course of indefinite duration.
A convex 3-D shape quality inhering in a bearer by virtue of the bearer's having a quadric surface in three dimensions obtained by rotating an ellipse about one of its principal axes. Includes spheres and oblate/prolate spheroids.
A spheroid quality inhering in a bearer by virtue of the bearer's exhibiting a polar diameter longer than its equatorial diameter.
A shape quality inhering in a bearer by virtue of it being a quadrilateral polygon in which all four angles are right angles.
A fluorescence quality inhering in a bearer by virtue of the bearer's exhibiting fluorescence which is self-induced.
A quality inhering in a bearer by virtue of the bearer's being abnormal and having a destructive effect on living tissue.
A shape quality inhering in a circular disk by virtue of the bearer's having a segment of another circle removed from its edge, so that what remains is a shape enclosed by two circular arcs of different diameters which intersect at two points (usually in such a manner that the enclosed shape does not include the center of the original circle).
A concave 3-D shape quality inhering in a bearer by virtue of the bearer's having the shape of a kidney.
A convex 3-D shape quality inhering in a bearer by virtue of the bearer's resemblance to a cube (a 3-D shape with a square cross section).
A convex 3-D shape quality inhering in a bearer by virtue of the bearer's exhibiting a consistently-sized round cross section.
A shape quality inhering in a bearer by virtue of the bearer's being cylindrical, in which the height is less than the diameter.
A shape quality inhering in a bearer by virtue of the bearer's having three angles.
A concave 3-D shape quality inhering in a bearer by virtue of the bearer's having two parts, roughly spherical and of equal size, connected by a bar.
A shape quality inhering in a bearer by virtue of the bearer's being shaped like a lance-head, considerably longer than wide, tapering towards the tip from below the middle; attached at the broad end.
A shape quality inhering in a bearer by virtue of the bearer's consisting of two curves, in opposite directions. S-shaped.
A concave 3-D shape quality inhering in a bearer by virtue of the bearer's being shaped in the form of the letter U.
A quality inhering in a bearer by virtue of the bearer's having a tail or tail-like projection.
A shape quality inhering in a bearer by virtue of the bearer's forming two equal obtuse triangles with a short side in common.
Gradually enlarged at the base, like the head of an arrow.
A concave 3-D shape quality inhering in a bearer by virtue of the bearer's resembling a slug.
A concave 3-D shape quality inhering in a bearer by virtue of the bearer's gradually becoming thicker towards the end.
A physical quality inhering in a bearer by virtue the bearer's disposition to being water-repellent; tending to repel and not absorb water.
A quality inhering in a bearer by virtue of the bearer's lacking affinity for water; tending to repel and not absorb water; tending not to dissolve in or mix with or be wetted by water.
A physical quality inhering in a bearer by virtue the bearer's disposition to having an affinity for water; it is readily absorbing or dissolving in water.
A quality inhering in a bearer by virtue of the bearer's disposition to having a strong affinity for water; tending to dissolve in, mix with, or be wetted by water.
A quality of a liquid inhering in a bearer by virtue of the bearer's ability to mix with (dissolve in) another liquid.
A surface feature shape quality inhering in a bearer by virtue of the bearer's having the border, edge, or outline cut into a series of segments of circles resembling a scallop-shell.
A concave 3-D shape quality inhering in a bearer by virtue of the bearer's being divided into three branches.
A spheroid quality inhering in a bearer by virtue of the bearer's exhibiting a continuous convex surface with an axis of symmetry and one axis longer than the other; egg-shaped.
An odor quality of having decreased odor.
An odor quality of having increased odor.
An organismal quality inhering in a bearer by virtue of the bearer's physical expression of sexual characteristics.
A biological sex quality inhering in an individual or a population that undergo sexual reproduction.
A structure quality inhering in a bearer by virtue of the bearer's lacking of a three dimensional space surrounded by one or more anatomical structures and containing one or more anatomical substances.
A structure quality inhering in a bearer by virtue of the bearer's having a three dimensional space surrounded by one or more anatomical structures and containing one or more anatomical substances.
See GO term: GO:0031974 membrane-enclosed lumen [DEF:"The enclosed volume within a sealed membrane or between two sealed membranes"].
A circumference which is relatively high.
A circumference which is relatively low.
A directional quality inhering in a bearer by virtue of the bearer's direction that is similar to the direction of an object to the south when it faces north.
A directional quality inhering in a bearer by virtue of the bearer's direction that is similar to the direction of an object to the north when it faces south.
A directional quality inhering in a bearer by virtue of the bearer's having one direction only.
A directional quality inhering in a bearer by virtue of the bearer's having two directions.
A directional quality inhering in a bearer by virtue of the bearer's direction approximating the shape of a circle.
The bearer of this quality has_part = n, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part.
A physical quality inhering in a bearer by virtue of the bearer's participation in movement.
A surface feature shape quality inhering in a bearer by virtue of the bearer's being like the surface of a compact mass of grapes.
A nucleate quality inhering in a bearer by virtue of the bearer's having more than one nucleus.
A nucleate quality inhering in a bearer by virtue of the bearer's having three nuclei.
A surface feature shape quality inhering in a bearer by virtue of the bearer's one part being layered over another connected part.
A behavioral quality inhering in a bearer by virtue of the bearer's exhibiting movement in a circular course.
A quality of a single process inhering in a bearer by virtue of the state of bearer's mechanical, physical, and biochemical processes.
A physiological state which is characterized by periods of high-frequency high amplitude electrical activity in neuronal tissue.
A physiological state which is characterized by normal electrical activity in neuronal tissue.
A spatial quality inhering in a bearer by virtue of the bearer's being located toward the front and upper surface of an organism relative to another entity.
A spatial quality inhering in a bearer by virtue of the bearer's being located toward the rear and upper surface of an organism relative to another entity.
A spatial quality inhering in a bearer by virtue of the bearer's being located toward the front and abdomen of an organism relative to another entity.
A spatial quality inhering in a bearer by virtue of the bearer's being located toward the rear and abdomen of an organism relative to another entity.
A positional quality inhering in a bearer by virtue of the bearer's being positioned towards the back or upper surface of an organism.
A positional quality inhering in a bearer by virtue of the bearer's being positioned towards the abdomen of an organism.
A positional quality inhering in a bearer by virtue of the bearer's being positioned towards the front of an organism.
A positional quality inhering in a bearer by virtue of the bearer's being positioned towards the rear of an organism.
A positional quality inhering in a bearer by virtue of the bearer's being positioned towards the side of an organism.
A positional quality inhering in a bearer by virtue of the bearer's being positioned towards the middle of an organism.
A surface shape quality inhering in a bearer by virtue of the bearer's shape of features present on its surface or outer shell.
This quality either inheres directly in the surface, or in the entity that has the surface. For example, to say that a particular fly wing is curved is shorthand for saying the wing has a surface which is curved.
A fluorescence which is higher than normal.
A fluorescence which is lower than normal.
A texture quality inhering in a bearer by virtue of a local accumulation of fluid underneath the surface of the bearer.
A variability quality inhering in a bearer by virtue of whether the bearer exhibits shape variation or change.
A quality inhering in a bearer by virtue the bearer's having or exhibiting variation its shape.
A quality inhering in a bearer by virtue of the bearer's lacking or not exhibiting variation of shape.
A pattern quality inhering in a bearer by virtue of the bearer's being placed alternately one above the other.
A positional quality inhering in a bearer by virtue of the bearer's being positioned on opposite sides on the same plane.
A shape quality inhering in a bearer by virtue of the bearer's being perfectly circular.
A shape quality inhering in a bearer by virtue of the bearer's being roundish, a little inclining to be oblong.
A spheroid quality inhering in a bearer by virtue of the bearer's being egg-shaped and flat, with the narrow end attached to the base.
A shape quality inhering in a bearer by virtue of the bearer's being oblong, with the lower end very much attenuated.
A spheroid quality inhering in a bearer by virtue of the bearer's being oval and a little angular in the middle.
A size quality inhering in a bearer by virtue of the bearer's being many folds greater relative to the normal average.
A color consisting of yellow and green hues.
A color consisting of brown and green hues.
A purple color which has low saturation and low brightness.
A color consisting of yellow and orange hue.
A moderate yellow-orange to orange color.
A color pattern inhering in a bearer by virtue of bearer's exhibiting transverse stripes of one hue or degree of saturation crossing another.
A color pattern inhering in a bearer by virtue of bearer's being covered with reticulated lines of a different hue or degree of saturation.
A grooved texture quality inhering in a bearer by virtue of the bearer's being marked by two or more parallel channels.
A shape quality inhering in a bearer by virtue of the bearer's terminating abruptly in a little point.
A shape quality inhering in a bearer by virtue of the bearer's terminating gradually in a rounded end.
A spatial pattern inhering in a bearer by virtue of the bearer's being in opposition round a common axis.
A spatial quality inhering in a bearer by virtue of the bearer's being arranged in two opposite rows (and hence in the same plane).
A pattern quality inhering in a bearer by virtue of the bearer's consisting of paired parts that alternately cross each other.
A shape quality inhering in a bearer by virtue of the bearer's being linear, very narrow, tapering to a very fine point from a narrow base.
A shape quality inhering in a bearer by virtue of the bearer's being narrowly triangular, wider at the apex and tapering toward the base.
A variability quality inhering in a bearer by virtue of whether the bearer exhibits size variation or change.
A variability of size which is relatively low.
A variability of size which is relatively high.
A structural quality inhering in a bearer by virtue of the bearer's in which bundles of aligned anatomical fibers have become separated.
A shape quality inhering in a bearer by virtue of the bearer's parts or projections being interlocked; for example, the fingers of two hands that are clasped.
A structural quality inhering in a bearer by virtue of the bearer's touching another entity.
A curled quality inhering in a bearer by virtue of the bearer's edges of its surface being rolled inwards spirally on each side.
A curled quality inhering in a bearer by virtue of the bearer's edges of its surface being rolled backwards spirally on each side.
A curled quality inhering in a bearer by virtue of the bearer's edges of its surface being rolled spirally downwards.
A curled quality inhering in a bearer by virtue of the bearer's edges of its surface being bent down upon their stalk.
A curled quality inhering in a bearer by virtue of the bearer's one edge of its surface being wholly rolled up in another.
A branched quality inhering in a bearer by virtue of the bearer's having three or more primary branches diverging radially from a single point.
A branched quality inhering in a bearer by virtue of the bearer's having two or more parallel primary branches originate beside each other and converge apically.
A branched quality inhering in a bearer by virtue of the bearer's having secondary branches terminating at the margin.
A branched quality inhering in a bearer by virtue of the bearer's having secondary branches joined together in a series of prominent arches.
A branched quality inhering in a bearer by virtue of the bearer's having secondary branches freely branching toward the margin.
A branched quality inhering in a bearer by virtue of the bearer's having secondary branches branching into a reticulum toward the margin.
A shape quality inhering in a bearer by virtue of the bearer's being tapering gradually into a rigid point.
A shape quality inhering in a bearer by virtue of the bearer's terminating in a round end, the centre of which is depressed.
A surface feature shape quality inhering in a bearer by virtue of the bearer's lacking sharp straight-edged teeth pointing to the apex.
A surface feature shape quality inhering in a bearer by virtue of the bearer's having or lacking sharp straight-edged teeth pointing to the apex.
A shape quality inhering in a bearer by virtue of the bearer's having at least one salient angle on the margin.
A shape quality inhering in a bearer by virtue of the bearer's being regularly divided by deep incisions.
A shape quality inhering in a bearer by virtue of the bearer's being partly divided into a determinate number of regions.
A shape quality inhering in a bearer by virtue of the bearer's having distinct parts arising from a common point or center.
A shape quality inhering in a bearer by virtue of the bearer's having a shape resembling an ear.
A shape quality inhering in a bearer by virtue of the bearer's gradually tapering to a slender point.
A structural quality inhering in a bearer by virtue of the bearer's two basal lobes being united together.
A shape quality inhering in a bearer by virtue of the bearer's being prolonged below the point of insertion.
A quality inhering in a bearer by virtue of the bearer's being kept below its freezing point.
A quality inhering in a bearer by virtue of the bearer's passing into solution.
A structural quality inhering in a bearer by virtue of the bearer's having a three dimensional cavity with a narrow or no opening, and often containing an anatomical substance.
A shape quality inhering in a bearer by virtue of the bearer's having four angles and four sides.
A curvature quality inhering in a bearer by virtue of the bearer's having many curves and turns.
A duration quality of a process inhering in a disease by virtue of the bearer's duration of an impairment of health or of a condition of abnormal functioning.
MAH: I think this term should be obsoleted. Is it used?
A quality inhering in a bearer by virtue of the bearer's disposition to being capable of indefinite growth or division.
An organismal quality inhering in a bearer by virtue of the bearer's consisting cells.
A cellularity quality inhering in a bearer by virtue of the bearer's consisting of more than one cell.
A cellularity quality inhering in a bearer by virtue of the bearer's consisting of exactly one cell.
A quality that inheres in an entire organism or part of an organism.
A quality inhering in a bearer by virtue of its visibility.
This term was created as a grouping term for the 2 terms "conspicuous" and "inconspicuous". However, it is not clear if these terms should even remain in PATO.
The bearer of this quality has_part < n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly. This case includes the limit case, where the bearer lacks all parts of the specified type.
A quality of physical entities inhering in a bearer by virtue of the bearer's lacking a physical part as specified by the additional entity.
Example: [E=organism Q=lacks_all_parts_of_type E2=Wing] - applies to an organism. A relational quality in which the bearer entity has no parts of the specified type. The bearer of this quality has_part = 0 of the indicated entity type, where a comparable organism usually has at least 1 part of the same type. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e lacks all parts of type X at time t, then there exists no instances x of X at t such that x part_of e that has no wings, where wings are normally present in that organism type. In OWL this is equivalent to a restriction on the OBO_REL:has_part relation with cardinality=0, i.e has_part 0 E2.
The bearer of this quality has_part < n AND has_part > 0 of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly.
Example: [E=hand Q=has_fewer_parts_of_type E2=digit] - applies to an organism that has no less fingers than is normal for organisms of that type.
The bearer of this quality has_part > n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part.
In polydactyly, the bearer of the quality is the hand, and the entity type being counted is 'finger'. In EQ syntax, E=hand, Q=<this> E2=finger.
A quality that inheres in an entire population or part of a population.
A shape that inheres in a part of a surface. An object can have different surface shapes on different parts of its surface.
Surface shape that refers to the inward or outward curvature of the surface.
A shape that inheres in a 2 dimensional entity, such as a cross section or projection of a 3 dimensional entity.
A complete three dimensional shape in which for every line connecting pair of points on the object is within the object. Or: a shape lacking cavities. Contrast: concave.
Use this term or an is_a child of this term when the entire shape of the object is known.
A complete three dimensional shape in which there is a line connecting pair of points on the object that lies outside the object. Or: a shape with cavities. Contrast: concave.
A shape quality inhering in a bearer by virtue of the degree to which there are subdivisions or offshoots in a bearer entity.
A texture quality inhering in a bearer by virtue of the bearer's bing full of small openings or gaps.
A structural quality which is held by a bearer when the latter's disposition the presence of abnormally proliferating masses of cells.
A texture quality that exists through a liquid cover on the surface of the bearer.
A structural quality inhering in a bearer by virtue of whether the bearer forms a bundle of anatomical fibers, as of muscle or nerve.
A structural quality that inheres in a bearer by virtue of the bearer's containing hollow areas.
A growth quality of occurrent in which the growth of an organism, structure or group of organisms does not occur.
Pink color having high brightness and low saturation.
A convex 3-D shape quality inhering in a bearer by virtue of the bearer's resembling a cone (a 3-D shape with a round cross section that tapers).
A concave 3-D shape quality inhering in a bearer by virtue of the bearer's resembling a minute projection (villus).
A positional quality inhering in a bearer by virtue of the bearer's location of features or characteristics along an apical-basal axis.
A positional quality inhering in a bearer by virtue of the bearer's location of features or characteristics along the anterior-posterior axis.
A convex angle that is formed by one side of a polygon and a line extended from an adjacent side.
A quality of a single process inhering in a bearer by virtue of the bearer's not increasing over time.
A concentration quality inhering in a bearer by virtue of the bearer's amount of osmoles of solute per kilogram of solvent.
A molecular quality that inheres in a molecular entity by virtue of whether the bearer exhibits the ability of a probe to react precisely with a specific target molecule.
A curvature quality inhering in a bearer by virtue of the bearer's being curved or tilted such that the tip points upwards.
A reflectivity quality inhering in light by virtue of the bearer's scattering occurring at small angle to the incident beam.
A reflective quality that is the light scattering occurring at wide angle (around 90 degrees) to the incident beam.
A shape quality inhering in a bearer by virtue of the bearer's being unseparated into parts or divisions.
A spatial quality inhering in a bearer by virtue of the bearer's being on the same side in relation to another structure.
A spatial quality inhering in a bearer by virtue of the bearer's being located towards the central axis of the organism or an extremity.
A structural quality inhering in a bearer by virtue of the bearer exhibiting deterioration of its structure.
A structural quality inhering in a bearer whose structure which does not deteriorate.
A concave quality inhering in a bearer by virtue of the bearer's curving inward on both sides or surfaces.
A shape quality inhering in a bearer by virtue of the bearer's being convex on both sides or surface.
A diameter that is along the anterior-posterior axis.
An anterior-posterior diameter quality which is relatively small.
An anterior-posterior diameter quality which is relatively large.
A shape quality inhering in a bearer by virtue of the bearer's being a quadrilateral with two parallel sides.
A branched quality inhering in a bearer by virtue of the bearer's having smaller branches arising from larger branches. Resembling a tree in branching structure.
A spatial quality inhering in a bearer by virtue of the bearer's being away from or on the opposite side of the central axis.
A spatial quality inhering in a bearer by virtue of the bearer's being located on the side nearest to the axis of an organ or organism.
An organismal quality inhering in a bearer by virtue of the bearer's having two or more cell populations that differ in genetic makeup. This situation can affect any type of cell, including blood cells, gametes (egg and sperm cells), and skin.
A curvature quality inhering in a bearer by virtue of the bearer's being curved around an axis and towards the side.
A quality inhering in a bearer by virtue of the bearer's being flattened along dorso-ventral axis.
A quality inhering in a bearer by virtue of the bearer's being flattened along transverse axis.
The specific wavelength of light emitted by a fluorescent molecule, such as a labelled probe, upon absorption of light at the (higher) excitation wavelength.
The specific wavelength of radiation that can be retained by a bearer.
A shape inhering in a bearer by virtue of the bearer's being elongated and cylindrical.
A structure quality inhering in a bearer by virtue of the bearer's delimited by a surface with holes.
A shape quality inhering in a bearer by virtue of the bearer's being arranged like rays or radii; radiating from a common center.
A solid configuration inhering in a material entity by virtue of its constituent atoms, molecules, or ions being arranged in an orderly repeating pattern extending in all three spatial dimensions.
A spatial pattern inhering in a bearer by virtue of the bearer's layered configuration.
A spatial pattern inhering in a bearer by virtue of the bearer's exhibiting a layered configuration.
A spatial pattern inhering in a bearer by virtue of the bearer's lacking a layered configuration.
A molecular quality that arises from the molecular attraction exerted between two atoms or compounds.
A molecular quality that arises from the synergistic strength of bond affinities between multiple bond interactions.
A behavioral quality inhering in a bearer by virtue of the bearer's movement.
A spatial quality inhering in a bearer by virtue of the bearer's being positioned with multiple entities of the same type above and below.
A quality inhering in a bearer by virtue of the bearer's having an empty space or cavity within.
A broken quality inhering in a bearer by virtue of the bearer's being separated into two contiguous wholes.
A broken quality inhering in a bearer by virtue of the bearer's being broken into multiple contiguous wholes.
A broken quality inhering in a bearer by virtue of the bearer's being still one contiguous whole but structurally damaged such that in danger of become two or more.
Terms were requested by the OBI consortium but it was later decided that the term was not reflecting a quality rather what it might be refered to as a "conferred quality".
The period before death of the organism.
A quality inhering in a bearer by virtue of the bearer's being short and wide and tapered distally.
A structure quality inhering in a bearer by virtue of the bearer's body containing one cyst - a formation of a sac-like closed membranous structure not associated with neoplasia.
A structure quality inhering in a bearer by virtue of the bearer's body containing more than one cyst - formations of sac-like closed membranous structures not associated with neoplasia.
A morphology quality inhering in a tumour by virtue of the bearer's exhibiting the morphological characteristics of a glandular epithelial cell.
A quality of a single process inhering in a bearer by virtue of the bearer's having an onset and time course between acute and chronic.
A morphology quality inhering in a neoplastic cell by virtue of the bearer's exhibiting breakdown of cell-cell interaction maintaining tissue architecture, proliferative dysregulation and bizarre modification to nucleus size and shape.
A volume quality inhering in a degenerating cell by virtue of the bearer's exhibiting an increase in volume associated with cytoplasmic abnormalities.
An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for basic dyes under specific pH conditions.
A disposition inhering in a tumour to progress or fail to progress during it's life time.
A disposition inhering in a tumour by virtue of the bearer's disposition not to progress, invade surrounding tissues or metastasize.
A disposition inhering in a tumour by virtue of the bearer's disposition to progress, invade surrounding tissues or metastasize.
A disposition inhering in a tumour by virtue of the bearer's disposition to spread and invade distant tissues.
A cellular quality inhering in a bearer by virtue of its stable specialization to a particular cell type.
A cellular quality inhering in a bearer by virtue of having not yet acquired a special structure of function.
A cellular quality inhering in a bearer by virtue of having changed from one fully differentiated state into another.
A cellular quality inhering in a cell that arises by virtue of whether the bearer exhibits the ability to grow and proliferate in number through cell division.
A structural quality inhering in a bearer by virtue of the bearer's penetrating or permeating another substance or area.
A compositional quality inhering in an bearer by virtue of the bearer's infiltration by leukocytes, local edema and accumulation of plasma proteins.
A structural quality inhering in a bearer by virtue of the bearer's exhibiting excessive discharge of blood from the blood vessels.
A cellular quality inhering in a bearer by virtue of its lacking most of the cellular characteristics which would allow it to be fully differentiated.
A positional quality inhering in a bearer by virtue of the bearer's being at the edge or boundary of a related entity.
A quality inhering in a bearer by virtue of the bearer's resembling small nipple like projection.
A structural quality inhering in a bearer by virtue of the bearer's resembling cheese.
A cellular quality inhering in a bearer by virtue of its having most of the cellular characteristics of the tissue of origin.
A cellular quality inhering in a bearer by virtue of its lacking few of the cellular characteristics which would allow it to be fully differentiated.
A structural quality inhering in a bearer by virtue of the bearer's having a hole or holes, especially a row or array of small holes.
A composition quality inhering in a bearer by virtue of the bearer's containing excess lipid.
A composition quality inhering in a bearer by virtue of the bearer's containing fibrin.
A composition quality inhering in exudate by virtue of the bearer's containing fibrin.
A morphology quality inhering in a bearer by virtue of the bearer's exhbiting the morphological characteristics of a gland.
A quality inhering in a bearer by virtue of the bearer's being present in more than two copies.
A structural quality which is held by a bearer when the latter exhibits an excessive accumulation of intracellular fluid.
A quality inhering a bearer by virtue of the bearer's ability to generate pus.
A spatial pattern inhering in a bearer by virtue of the bearer's structure resembling an irregular meshwork with cross-linking struts.
A composition quality inhering in a bearer by virtue of the bearer's being composed of more than one identifiable entities.
Being smallest in amount, extent or degree.
A quality inhering in a bearer by virtue of the bearer's processing the form of a thin plate sheet or layer.
A quality inhering in a bearer by virtue of the bearer's consisting a knot-like mass.
A quality inhering in a bearer by virtue of the bearer's containing bone.
A hardness quality of being rigid and resistant to pressure and fibrous.
A quality inhering a bearer by virtue of the bearer's containing or resembling serum.
A disposition inhering in a tumour by virtue of the bearer's disposition to invade surrounding tissues.
A disposition inhering in a tumour by virtue of the bearer's disposition to invade surrounding tissues to a large extend.
A displaced angular placement quality inhering in a body part by virtue of the bearer's movement away from the medial plane of the body.
A disposition inhering in a tumour by virtue of the bearer's disposition not to invade surrounding tissues.
A displaced angular placement quality inhering in a body part by virtue of the bearer's movement closer the medial plane of the body.
This term is also used in reference to the operation of the muscle in anatomy or musculature.
A composition quaity inhering in a bearer by virtue of the bearer's containing of or pertaining to fibrils, or nanoscale fibers.
A duration quality of a process inhering in a bearer by virtue of the bearer's delay to complete the closure of the opening of an anatomical entity.
A quality inhering in a bearer by virtue of the bearer's relative inability of electromagnetism to pass through a particular material, particularly X-rays.
A radiopacity quality inhering in a bearer by virtue of the bearer's prevention of the passage of electromagnetic radiation.
A physical quality inhering in a bearer by virtue of the bearer's disposition to being fit to be eaten.
A physical quality inhering in a bearer by virtue of the bearer being suitable for use as food.
A physical quality inhering in a bearer by virtue of the bearer not being suitable for use as food.
A quality inhering in a bearer by virtue of the severity of infectious disease caused by the bearer in a target organism.
A quality inhering in a bearer by virtue of the bearer exhibiting increased density resulting in exhibiting increased degree of radiopacity (in X-rays).
A curvature quality inhering in a bearer by virtue of the bearer's being curved outwards from the part of the body from which the tail arises.
A curvature quality inhering in a bearer by virtue of the bearer's being curved outwards from the back or upper surface of an organism.
A curvature quality inhering in a bearer by virtue of the bearer's being curved outwards from the side.
A curvature quality inhering in a bearer by virtue of the bearer's being curved outwards the front of an organism.
A curvature quality inhering in a bearer by virtue of the bearer's being curved outwards the abdomen of an organism.
A rotation quality inhering in a bearer by virtue of being rotated towards the middle of an organism.
A rotation quality inhering in a bearer by virtue of being rotated towards the side of an organism.
A positional quality inhering in a bearer by virtue of the bearer's being slightly out of its usual or proper place, or position.
Having two horns or horn-shaped branches.
A concave quality inhering in a bearer by virtue of the bearer's forming or resembling an arch of an increased apical height.
A quality inhering in a bearer by virtue of the bearer's bodily structure that has protruded through an abnormal opening in the wall that contains it into the surface or boundary of another entity.
A curvature quality inhering in a bearer by virtue of the bearer's being curved towards the middle.
A duration quality of a process inhering in a bearer by virtue of the bearer's premature completion of the closure of the opening of an anatomical entity.
A protruding quality inhering in a bearer by virtue of the bearer's bodily structure that has protruded out of the surface or boundary of another entity.
An angular placement quality inhering in a bearer by virtue of the bearer being changed in position in relation to another entity.
A shape quality inhering in a bearer by virtue of the bearer's being split along the median axis.
A shape quality inhering in a bearer by virtue of the bearer's being split asymmetrically on one side.
A shape quality inhering in a bearer by virtue of the bearer's being split on two side.
A shape quality inhering in a bearer by virtue of the bearer's being split along the radial axis.
An alignment quality inhering in a bearer by virtue of the bearer's being in a improper spatial positioning towards an additional entity.
An alignment quality inhering in a bearer by virtue of the bearer's being in a improper spatial positioning away from an additional entity.
A spatial quality inhering in a bearer by virtue of the bearer's changed direction of position towards another entity.
A deviation quality inhering in a bearer by virtue of the bearer's changed direction of position towards the side.
A deviation quality inhering in a bearer by virtue of the bearer's changed direction of position towards the middle.
A positional quality inhering in a bearer by virtue of the bearer's being out of its usual or proper place, or position around a central point or axis.
A positional quality inhering in a bearer by virtue of the bearer's being positioned towards to point of attachment or origin.
A shape quality inhering in a bearer by virtue of the bearer's being free of curves, bends, or angles.
A positional quality inhering in a bearer by virtue the bearer's being changed in position.
A quality which inheres in a molecular entity, a single molecule, atom, ion, radical etc.
A molecular quality that inheres in a molecular entity by virtue of whether that there is a presence of cycles in the connection of the atoms within the molecular entity.
Cyclic cyclicity inheres in a molecule when the atoms of the molecule do contain at least one cycle in the atom-atom connection paths (through bonds).
Acyclic cyclicity inheres in a molecule when the atoms within the molecule do not contain at least one cycle in the atom-atom connection paths (through the bonds).
A molecular quality that inheres in a molecular entity by virtue of whether or not the molecular entity has a separation of electric charge which leads to the molecule having an electric dipole.
Polar polarity is a quality that inheres in a molecular entity when the molecular entity is polar, i.e. does possess an electric dipole.
A molecular quality which inheres in a molecular entity when the molecular entity does not possess an electrical dipole.
The ease of distortion of the electron cloud of a molecular entity by an electric field.
A molecular quality that inheres in a molecular entity by virtue of the presence of a conjugated ring of unsaturated bonds, lone pairs, or empty orbitals that exhibit a stabilization stronger than would be expected by the stabilization of conjugation alone.
A molecular quality that inheres in a molecular entity when it possesses at least one ring that is aromatic, i.e. A conjugated ring of unsaturated bonds, lone pairs, or empty orbitals that exhibit a stabilization stronger than would be expected by the stabilization of conjugation alone.
A quality that inheres in a molecular entity by virtue of the molecule possessing no rings that are aromatic.
A molecular quality that inheres in a molecular entity by virtue of the overall electric charge of the molecule, which is due to a comparison between the total number of electrons and the total number of protons.
A quality which inheres in a molecular entity by virtue of the molecular entity possessing the same amount of electrons overall as protons, thus having an overall neutral charge.
A quality which inheres in a molecular entity by virtue of the molecular entity possessing more protons overall than electrons, thus having an overall positive charge.
A quality which inheres in a molecular entity by virtue of the molecular entity possessing more electrons overall than protons, thus having an overall negative charge.
A quality that describes the power of an atom to attract electrons to itself .
A quality inhering in a bearer by virtue of its constitution.
A quality which inheres in a substance by virtue of the ease with which the substance can be changed from a solid to a liquid state especially by the application of heat.
A quality which inheres in a substance by virtue of the ease with which the substance can be changed into a gaseous state.
A behavioral quality inhering ina bearer by virtue of the bearer's unequal distribution of fine motor skill between its left and right hands or feet.
Adapted from Wikipedia and the birnlex term that is dbxref'd. Added on behalf of OBI at March 2010 workshop.
Handedness where the organism preferentially uses the left hand or foot for tasks requiring the use of a single hand or foot or a dominant hand or foot.
Handedness where the organism preferentially uses the right hand or foot for tasks requiring the use of a single hand or foot or a dominant hand or foot.
Handedness where the organism exhibits no overall dominance in the use of right or left hand or foot in the performance of tasks that require one hand or foot or a dominant hand or foot.
A quality inhering in a bearer by virtue of the bearer's ability to hold an electrical charge.
Capacitance is also a measure of the amount of electrical energy stored (or separated) for a given electric potential.
A maturity quality inhering to a bearer by virtue of the bearer's being at the point or short after birth.
A quality that is the distance between the end of the inserted object and the surface of the object into which it penetrates.
A concave 3-D shape quality inhering in a bearer by virtue of the bearer's being shaped in the form of a spoon.
A shape quality inhering in a bearer by virtue of the bearer's having the shape of an incisor tooth.
A convex 3-D shape quality inhering in a bearer by virtue of the bearer's resembling a teardrop.
A curvature quality inhering in a bearer by virtue of the bearer's being curved backward or inward.
A shape quality inhering in a bearer by virtue of the bearer's being small or narrow in circumference or width in proportion to length or height.
A concave 3-D shape quality inhering in a bearer by virtue of the bearer's shape being inversely clavate.
A lobed quality inhering in a bearer by virtue of the bearer's being divided into or having two lobes.
A shape quality inhering in a bearer by virtue of the bearer's having the shape of a scythe or sickle.
A molecular quality that pertains to the post-translational modification of a protein by the covalent attachment of one or more ubiquitin monomer.
A molecular quality inhering in a bearer by virtue of the bearer's being combined, or impregnated, with nitric acid, or some of its compounds.
A quality inhering in a bearer by virtue of the bearer's loss of myelin sheath.
For example loss of myelin sheath from a normally myelinated axon or dendrite.
A quality inhering in a bearer that is shaped in the form of a fan.
A quality inhering in a protein or a molecule by virtue of the bearer's having a phosphate (PO4) group.
A quality inhering in a bearer by virtue of the bearer's being phosphorylated to a more than normal extent, or fully saturated with phosphate groups.
A quality inhering in a bearer by virtue of the bearer's being phosphorylated to a lesser than normal extent, or less than fully.
A quality inhering in a bearer by virtue of the bearer's having reacted with oxygen, or been modified by oxidation (the reaction in which the atoms of an element lose electrons and the valence of the element increases).
An angular shape quality inhering in a bearer by virtue of the bearer's having a single angle in its length giving the bearer the form of the letter V.
An angular shape quality inhering in a bearer by virtue of the bearer's having a single angle in its length giving the bearer the form of the letter L.
A cylindrical shape quality inhering in a bearer by virtue of the bearer's being imperfectly cylindrical or approximately cylindrical.
A concave 3-D shape quality inhering in a bearer by virtue of the bearer's shape form resembling the shape of a cup.
A tapered shape quality inhering in a bearer by virtue of the bearer's tapering gradually to a sharp point.
A quadrangular shape quality inhering in a bearer by virtue of the bearer's being approximately rectangular.
A triangular shape quality inhering in a bearer by virtue of the bearer's being nearly, but not perfectly, triangular.
A split shape quality inhering in a bearer by virtue of the bearer's having or being divided into many lobes or similar segments.
A 2-D shape quality inhering in a bearer by virtue of the bearer's having shape or form of half a circle.
A spatial quality inhering in a bearer by virtue of the bearer's being located far (not close to) in space in relation to another entity.
A notched shape quality inhering in a bearer by virtue of the bearer's having a notched tip or edge.
A tapered shape quality inhering in a bearer by virtue of the bearer's being flat, slender, and tapering to a point.
Shape quality inhering in a bearer by virtue of the bearer's being shaped like a wing.
A curvature quality inhering in a bearer by virtue of the bearer's being curved backward or downward.
A curvature quality inhering in a bearer by virtue of the bearer's being curved forward or upward.
A concave 3-D shape that inheres in the bearer by virtue of the bearer's nearly) symmetric shape wide at its ends and narrow in the middle, resembling the figure of number 8.
A convex 3-D shape quality inhering in a bearer by virtue of the bearer's shape resembling falling drop.
A lobed quality inhering in a bearer by virtue of the bearer's being divided into or having three lobes.
A physical quality inhering in a bearer by virtue of the bearer's rate of change of the position.
A physical quality inhering in a fluid (liquid or gas) by virtue of the amount of fluid which passes through a given surface per unit time.
A flow rate quality inhering in a substance by virtue of the mass of substance which passes through a given surface per unit time.
A quality inhering in a bearer by virtue of the bearer's having or lacking of substances produced by living organisms that have a color resulting from selective color absorption.
A degree of pigmentation quality inhering in a bearer by virtue of the bearer's having substances produced by living organisms that have a color resulting from selective color absorption.
A degree of pigmentation quality inhering in a bearer by virtue of the bearer's lacking substances produced by living organisms that have a color resulting from selective color absorption.
A degree of pigmentation quality that is relatively high.
A degree of pigmentation quality that is relative low.
A quality inhering in a bearer by virtue of the bearer's being flattened along the antero-posterior axis.
A quality inhering in a bearer by virtue of the bearer's being roundish, flattish shape, possibly with a slightly angled edge.
A quality inhering in a bearer by virtue of the bearer's surface becoming more extended in a plane.
Becoming flat but not necessarily completely flat.
Texture quality inhering in a bearer by virtue of the bearer's being marked with one or more channels.
A cuscpidate quality inhering in a bearer by virtue of the bearer possessing three cusps.
A cuscpidate quality inhering in a bearer by virtue of the bearer possessing more than one cusp.
A shape quality inhering in a bearer by virtue of the bearer's having a point.
A spatial quality inhering in a bearer by virtue of the bearer's being located near in space in relation to another entity.
A quality inhering in a bearer by virtue of the bearer's being partially upright in position or posture.
A spatial quality inhering in a bearer by virtue of the bearer's location within another entity.
A quality inhering in a protein or a molecule by virtue of the addition of a phosphate (PO4) group to the bearer.
A quality inhering in a protein or a molecule by virtue of the bearer's lacking a phosphate (PO4) group.
A structural quality inhering in a bearer by virtue of the bearer's being arranged in a systematic fashion.
A behavioral quality of a process inhering in a bearer by virtue of the bearer's disposition to exhibit marked activity.
A shape that inheres in a 3 dimensional entity.
A positional quality inhering in a bearer by virtue of the bearer's being located in a position equidistant from edges.
A structural quality of the collection or massing of one physical object within another physical object.
An increased number of physical objects that are accumulated within another physical object usually as a result of a failure to break down or remove objects in a timely manner.
A spatial quality inhering in a bearer by virtue of the bearer's being located at the same continuous distance relative to another object.
Multicolored quality inhering in a bearer by virtue of the bearer's being colored with a variegated pattern resembling marble,.
Multicolored quality inhering in a bearer by virtue of the bearer's being dappled with spots, patches, or blotches of different colors.
A color pattern quality inhering in a bearer by virtue of the bearer's color pattern in which light and dark colors (for example white and black) are codistributed to create a visual impression.
A color pattern inhering in a bearer by virtue of bearer's exhibiting vertical bars of one hue or degree of saturation crossing another.
A quality of certain surfaces which appear to change colour as the angle of view changes.
A structural quality inhering in a bearer by virtue of the bearer's participating in a joint with another entity.
A structural quality inhering in a bearer by virtue of the bearer's being strongly articulated with another entity.
A structural quality inhering in a bearer by virtue of the bearer's possessing a broad surface in articulation with another entity.
A cuscpidate quality inhering in a bearer by virtue of the bearer possessing two cusps.
A physical quality that pertains by virtue of a pulling force that is directed away from the bearer and attempts to stretch or elongate the bearer.
Branchiness quality inhering in a bearer by virtue of increasing the degree to which there are subdivisions or offshoots in a bearer entity.
Branchiness quality inhering in a bearer by virtue of decreasing the degree to which there are subdivisions or offshoots in a bearer entity.
A hairy quality inhering in a bearer by virtue of the bearer's being covered with setae.
Setose as a label is used extensively to describe insect phenotypes that have hairy-like appearances (i.e., they are covered in setae, not the hairs of mammals). A bristle is a type of seta.
Decreased size or absence of organ, tissue or cell due to a reduction in cell numbers.
Absence of a tissue or organ due to failure to develop.
A structural quality inhering in a bearer by virtue of the bearer's underlying structure being capable of change.
For example, structures undergoing endochondral ossification change in composition from cartilaginous to ossified.
A structural quality inhering in a bearer by virtue of the bearer's underlying structure not changing over time.
A texture that is uniformly covered in short, oblong, or trench-like depressions.
A surface feature shape inhering in a surface by virtue of the bearer's being divided by ridge-like structures into a number of small, irregular spaces.
A texture quality inhering in a surface by virtue of the bearer's being marked by the presence of small, shallow, regular depressions called fovae.
A cellular motility which is lower relative to the normal or average.
A cellular motility which is higher relative to the normal or average.
A quality that has a value that is increased compared to normal or average.
A quality that has a value that is decreased compared to normal or average.
A quality of a process that has a value that is decreased compared to normal or average.
A quality of an object that has a value that is decreased compared to normal or average.
A quality of a process that has a value that is increased compared to normal or average.
A quality of an object that has a value that is increased compared to normal or average.
A triangular quality inhering in a bearer by virtue of the bearer's having all sides of the same length.
A triangular quality inhering in a bearer by virtue of the bearer's having two sides have the same length.
A triangular quality inhering in a bearer by virtue of the bearer's having all sides of unequal length.
A convex 3-D shape quality inhering in a bearer by virtue of the bearer's exhibiting a by virtue of the bearer's exhibiting a consistently sized and approximately round cross-section along its length, which is many times larger than its diameter.
Note that a fiber shaped object may take any circuitous or straight path through space (think of a length of string or rope).
A quality inhering in a bearer by virtue of the bearer's being strong, thick or sturdy.
Having a fringe or border of hairlike or fingerlike projections.
Consisting of segments or similar parts arranged in a longitudinal series.
Having or resembling the shape of a telescope.
Having the nature or characteristic of, a ligament; composed of the tissue proper to ligaments.
A shape quality inhering in a bearer by virtue of the bearer's resembling the end of a brush with a multitude of bristles.
Being separate or discrete from other skeletal elements.
A convex quadrilateral is a parallelogram if and only if any one of the following statements are true: 1. Each diagonal divides the quadrilateral into two congruent triangles with the same orientation. 2. The opposite sides are congruent in pairs. 3. The diagonals bisect each other. 4. The opposite angles are congruent in pairs. 5. The sum of the squares of the sides equals the sum of the squares of the diagonals. (This is the parallelogram law) 6.It possesses rotational symmetry. 7.One pair of opposite sides are parallel and congruent. 8.Two pairs of adjacent angles are supplementary.
A shape constituting a transition between a rectangle and a circle; a closed curve, of which the circle and ellipse are special cases, whose parametric equation is x = a.cos2/rt, y = b.cos2/rt
A shape with properties between those of a square and those of a circle.
A superelliptic shape inhering in a bearer by virtue of the bearer's shape resembling a diamond.
A temporal distribution pattern of process occurrences within a regulation/reference process.
The temporal relation between the end of the process with respect to a reference process.
The temporal relation between the start of the process with respect to a reference process.
An orientation inhering in a bearer by virtue of the bearer's placement at an angle.
A shape quality inhering in a bearer by virtue of the bearer's exhibiting a upward bending of its leaves or other plant parts.
A quality inhering in a bearer by virtue of the bearer's being extended along a straight line, and is shaped like a reversed lance-point, with the tapering point attached to the leafstalk.
A physical quality inhering in a bearer by virtue of the bearer exhibiting molecular attraction to another entity in contact.
A physical quality inhering in a bearer by virtue of the bearer not exhibiting molecular attraction to another entity in contact.
A shape quality inhering in a bearer by virtue of the bearer's being dome-shaped.
A shape quality inhering in a bearer by virtue of the bearer's having triangular faces that meet at a common point and containing a polygonal shaped base.
A spheroid quality inhering in a bearer by virtue of the bearer's exhibiting a continuous convex surface with an axis of symmetry and one axis longer than the other; characterized with an egg-shaped form crossed with a lance-head shaped form.
A shape quality inhering in a bearer by virtue of the bearer's being shaped like a lance-head, considerably longer than wide, tapering towards the tip from below the middle together forming three angles; attached at the broad end.
A quality of being covered with stiff or rough hairs.
A quality of being covered with short, dense, matted hairs.
A quality inhering in a bearer by virtue of the bearer's being a cupule, with a structure similar to a cup that also encloses the ovule in partiality.
A positional quality inhering in a bearer by virtue of the bearer's lying or growing on the ground but with erect or rising tips.
A quality inhering in a bearer by virtue of the bearer's being characterized by fine, entangled hairs giving the appearance of cobweb.
A convex 3-D shape quality inhering in a bearer by virtue of the bearer's having a quadric surface in three dimensions obtained by rotating less than half of a circular arc about an axis passing through the endpoints of the arc
A concave 3-D shape quality inhering in a bearer by virtue of the bearer's having two connected parts, roughly spherical, of different sizes.
A conical quality inhering in a bearer by virtue of the bearer's resembling a cone, with the pointed end attached to an organism.
A structural quality inhering in a bearer by virtue of the bearer resembling wood.
A spatial quality inhering in a bearer by virtue of the bearer's being located toward the base of an organism relative to another entity.
A spatial quality inhering in a bearer by virtue of the bearer's being located toward the stalk of an organism relative to another entity.
A structural quality inhering in a bearer by virtue of the bearer resembling or containing flesh.
A quality inhering in a bearer by virtue of the bearer's upper parts die back to the rootstock at the end of the growing season.
A quality that inheres in a bearer in virtue of its realizing one of its functions.
A quality of an physical object that is currently realizing one of its functions.
A quality of a physical object that is currently realizing none of its functions.
A quality of a physical object that has been constantly realizing some of its functions.
A shape quality inhering in a bearer by virtue of the bearer's having a strait side and an arched side giving the bearer the form of the letter D.
A quality inhering in a bearer by virtue of the bearer's width being notably higher than its length.
A disposition that can be compared on a linear scale - that is that it can be increased or decreased.
A medium brown color with a metallic sheen, resembles the actual alloy bronze.
A quality inhering in a bearer by virtue of the bearer's length being notably lower than its width.
Female quality of having complete, unaltered reproductive organs
Male quality of having complete, unaltered reproductive organs.
Male quality of being incapable to reproduce because of functional loss of the testicles from surgical removal or chemical means.
A viviparous organism having never given birth.
A viviparous organism that has given birth two or more times.
The number of time that a viviparous organism has given birth.
A viviparous organism having given birth one time.
A viviparous organism that has given birth five or more times.
A positional quality inhering in a bearer by virtue of the bearer's location of features or characteristics along the mediolateral axis.
Recurrent and often more or less cyclic alteration.
A concave 3-D shape quality inhering in a bearer by virtue of the bearer's shape form resembling the shape of a trumpet.
A structure quality inhering in a bearer by virtue of the bearer's being filled with air.
A structure quality inhering in a bearer by virtue of the bearer's being not filed with air.
Having a shape that resembles a many-lobed "berry," such as a raspberry.
A female fertility quality inhering in a female by virtue of the bearer's not being capable of reproducing because of surgical removal of ovaries and uterus.
A female fertility quality inhering in a female by virtue of the bearer's not being capable of reproducing because of surgical removal of ovaries.
A composition quality inhering in an bearer by virtue of the presence of long chain aliphatic lipids on the surface of an organism.
Presence of long chain aliphatic lipids on the surface of an organism.
A shape quality inhering in a bearer by virtue of the bearer's being marked by narrow lines, usually parallel, with at least one salient angle on the margin
A concave 3-D shape that inheres in the bearer by virtue of the bearer's shape that is wider at one end and narrow in the middle.
Extremely acute and aggressive onset of a pathological process.
Growing horizontal to the ground without setting roots.
A length quality which is equal to the length of any straight line segment that passes from the center of a circle to any endpoint on the circular boundary. The radius is half of the diameter.
A shape quality inhering in a bearer by virtue of the bearer's having three rays or radiating branches.
A spatial quality inhering in a bearer by virtue of the bearer's being located on a sloping line joining two nonconsecutive points of an entity relative to another entity.
A tolerance quality inhering in a bearer by virtue of the bearer's increased ability to endure a stimulus.
A tolerance quality inhering in a bearer by virtue of the bearer's decreased ability to endure a stimulus.
A positional quality inhering in a bearer by virtue of the bearer's being positioned away from the axis of an organism.
A positional quality inhering in a bearer by virtue of the bearer's being positioned towards the axis of an organism.
A circular shape quality inhering in a bearer by virtue of the bearer's being nearly, but not perfectly, circular.
A rotation quality inhering in a bearer by virtue of being rotated towards the front and the middle of an organism.
Having a spindle-like shape that is wide in the middle and tapers at both ends.
characterised by an unidentifiable pattern.
Multiple lesions some interconnecting with each other.
Affecting all regions without specificity of distribution.
A structural quality inhering in a bearer by virtue of the bearer's disposition to be reduced to smaller pieces with little effort.
Easily reduced to powder or easily fragmentable or crumbly.
Having become firm or hard especially by increase of fibrous elements.
A colour that is very pale yellowish brown.
A color consisting of yellow and brown hue.
A color consisting of yellow and brown hue and low brightness.
A color consisting of yellow and brown hue and high brightness.
A quality of duration having progressive course of indefinite duration with active, acute-like elements.
Single lesion with expansion into surrounding tissue.
Flattened from above downward; below the normal level or the level of the surrounding parts.
Extending through or affecting the entire thickness of the wall of an organ or cavity or boundary.
An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for acidic dyes under specific pH conditions.
Eosin stains acidophilic structures, hence eosinophilic is the same as acidophilic.
OBSOLETE. An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for eosin dye.
Eosin stains acidophilic structures, hence eosinophilic is the same as acidophilic. See https://github.com/pato-ontology/pato/issues/471
Having both hydrophilic and hydrophobic (or lipophilic) groups.
Having or resembling the characteristic of a cicatrix - a scar resulting from formation and contraction of fibrous tissue.
Pertaining to the individual parts making up an aggregate fruit like a many-lobed "berry," such as a raspberry.
A round or lobulated protruding form resembling a nipple.
A positional quality inhering in a bearer by virtue of the bearer's having two or more entities that extend from a common point in different directions.
Open to view or not covered by another entity.
A shape quality inhering in a bearer by virtue of the bearer's being shaped like a boat.
A surface feature shape having numerous very small circular rounded projections or protuberances.
A 3-D shape with three supports or legs.
A shape quality inhering in a bearer by virtue of the bearer's being shaped in the form of the letter X.
A shape quality in which the bearer is shaped like a narrow band; ligulate.
A shape quality in which the bearer possesses a gradual, yet distinct, thinning from a wide starting point.
A surface feature shape marked by large amounts of relief, often with multiple ridges and grooves in close association. Topographically complex.
A spatial quality inhering in a bearer by virtue of the bearer's being located at a right angle relative to another entity.
A positional quality inhering in a bearer by virtue of the bearer touching another entity along a border or with a projecting part.
A positional quality inhering in a bearer by virtue of the bearer's position being displaced from a reference point.
A structural quality inhering in a bearer by virtue of the bearer's being locked together or interconnected to another entity.
A structural quality inhering in a bearer by virtue of the bearer's being located or placed beneath the skin.
An angular shape quality inhering in a bearer by virtue of the bearer's having two angles in its length giving the bearer the form of the letter W.
A surface feature shape quality inhering in a bearer by virtue of the degree of the bearer's highly topographical with ridges, pits, rugosity or other surface structures.
A surface feature shape in which the bearer's surface is highly topographical with ridges, pits, rugosity or other surface structures.
A surface feature shape in which the bearer's surface is lacking ridges, pits, rugosity or other surface structures.
A positional quality inhering in a bearer by virtue of the bearer's being located at the same level as another entity.
A composition quality inhering in a bearer by virtue of the bearer's being composed of or possessing inorganic material.
A shape quality inhering in a bearer by virtue of the bearer's being twisted or turned.
The word "torsion" has multiple different meanings in different context (e.g. the act of twisting or the morphology of the digestive tract in gastropods). This term refers purely to the resulting shape and is not to be used in the engineering and mechanics sense of torsion. Note: kinked PATO:0001798(synonym twisted) is similar to 'torsioned', but it is different in that something that is kinked has sharp twists or turns.
A shape quality inhering in a bearer by virtue of the bearer's having a shape resembling an anchor.
A shape quality inhering in a bearer by virtue of the bearer being divided into four parts.
A quality inhering in a bearer by virtue of the bearer's being aligned or positioned towards another entity.
A spatial quality inhering in a bearer by virtue of the bearer's being located toward the rear and mid-line surface of an organism relative to another entity.
A hardness quality of giving significant resistance to pressure.
A quality inhering in a bearer by virtue of the bearer's exhibiting a phenotypic difference between males and females of the same species.
A structural quality inhering in a bearer by virtue of the bearer being thinner or more loosely packed.
A structural quality inhering in a bearer by virtue of the bearer bring gradually worn away.
A quality inhering in a bearer by virtue of the bearer's similarity to the appearance of a carpel.
A quality inhering in a bearer by virtue of the bearer's architecture bearing resemblence to a corymb type of inflorescence.
A quality inhering in a bearer by virtue of the bearer's similarity to the appearance of an inflorescence.
A structural quality inhering in a bearer by virtue of the bearer's similarity to the appearance of a leaf.
A quality inhering in a bearer by virtue of the bearer being thin and lacking outgrowths.
A structural quality inhering in a bearer by virtue of the bearer's similarity to the appearance of a sepal,
A structural quality inhering in a bearer by virtue of the bearer being smaller and contracted, especially due to loss of moisture.
To bend or hang downwards due to loss of water
A composition quality inhering in an bearer by virtue of the bearer's consisting of collagen.
A positional quality inhering in a bearer by virtue of some aspect of the bearer extending to the position of another entity.
A positional quality inhering in a bearer by virtue of some aspect of the bearer extending past the position of another entity.
A quality inhering in a bearer by virtue of the bearer's resembling a prism.
A shape quality inhering in a bearer by virtue of the bearer resembling a keyhole.
A shape quality inhering in a bearer by virtue of the bearer resembling a thin narrow strip.
A structure quality inhering in a bearer by virtue of the bearer's being capable of swelling or stretching.
Structural quality inhering in a bearer in which a joint has apposed bony surfaces united by fibrous tissue, permitting no movement; found only between bones.
A morphological quality between two bearers inhering that one bearer is subject to change the nature, function, or condition of itself to become the other.
A physical quality inhering in a bearer by virtue of the bearer's increased rate of change of the position.
A physical quality inhering in a bearer by virtue of the bearer's decreased rate of change of the position.
A disposition inhering in a tumour by virtue of the bearer's disposition to spontaneously arise.
A flavor quality inhering in a bearer by virtue of the bearer's having an acrid, sharp, or disagreeable flavor.
A position quality inhering in a bearer by virtue of the bearer's existing near the end of another entity.
A position quality inhering in a bearer by virtue of the bearer's forming the end of another entity.
A structural quality inhering in a bearer by virtue of the bearer's disposition to breaks without significant deformation (strain) when subjected to stress.
A shape quality inhering in a bearer by virtue of the bearer's being marked by narrow lines or grooves, usually parallel, that are oriented transversely relative to the long axis of the bearer.
A shape quality inhering in a bearer by virtue of the bearer's being marked by narrow lines or grooves, usually parallel, that are oriented obliquely relative to the long axis of the bearer.
A quality inhering in an bearer by virtue of the bearer's possessing only minor levels of ossification.
An orientation quality inhering in a bearer by virtue of the bearer having a slanting direction or position : neither perpendicular nor parallel.
Shape quality inhering in a bearer by virtue of the bearer exhibiting a narrow and elongate opening.
Positional quality in which an entity is located outside of another entity.
An angular shape quality inhering in a bearer by virtue of the bearer's having a single angle in its length giving the bearer the form of an inverted letter V.
A shape quality inhering in a bearer by virtue of the bearer's possessing two sides that are at the same continuous distance relative to each other.
A quality inhering in a process by virtue of that process having two or more organisms as participants.
A quality inhering in a process by virtue of that process having exactly one organism as a participant.
Overlap with quality inhering in a bearer by virtue of the bearer's being positioned over another entity so as to cover some portion of it.
Overlap with quality inhering in a bearer by virtue of the bearer's being positioned under another entity so as to be covered by some portion of it.
An orientation quality inhering in a bearer by virtue of the bearer having a position that is directed anteriorly.
An orientation quality inhering in a bearer by virtue of the bearer having a position that is directed anterodorsally.
An orientation quality inhering in a bearer by virtue of the bearer having a position that is directed anterolaterally.
An orientation quality inhering in a bearer by virtue of the bearer having a position that is directed anteroventrally.
An orientation quality inhering in a bearer by virtue of the bearer having a position that is directed distally.
An orientation quality inhering in a bearer by virtue of the bearer having a position that is directed dorsally.
An orientation quality inhering in a bearer by virtue of the bearer having a position that is directed dorsolaterally.
An orientation quality inhering in a bearer by virtue of the bearer having a position that is directed laterally.
An orientation quality inhering in a bearer by virtue of the bearer having a position that is directed medially.
An orientation quality inhering in a bearer by virtue of the bearer having a position that is directed posteriorly.
An orientation quality inhering in a bearer by virtue of the bearer having a position that is directed ventrolaterally.
An orientation quality inhering in a bearer by virtue of the bearer having a position that is directed ventrally.
An orientation quality inhering in a bearer by virtue of the bearer having a position that is directed transversely.
An orientation quality inhering in a bearer by virtue of the bearer having a position that is directed posterolaterally.
An orientation quality inhering in a bearer by virtue of the bearer having a position that is directed posterodorsally.
A nucleate quality inhering in a bearer by virtue of the bearer's having one or more nucleus.
A surface feature shape quality inhering in a bearer by virtue of the bearer's not having undulating edges forming lobes.
A composition quality inhering in a bearer by virtue of the bearer's consisting of keratin.
A positional quality inhering in a bearer by virtue of the bearer being hidden from view.
A 2-D shape quality inhering in a bearer by virtue of the bearer's having six angles and six sides.
A concave 3-D shape quality inhering in a bearer by virtue of the bearer being divided into multiple parts.
A shape quality inhering in a bearer by virtue of the bearer's similarity to the appearance of a cane.
A positional quality inhering in a bearer by virtue of the bearer flowing or coming together with another entity.
A positional quality inhering in a bearer by virtue of the bearer's having a slanting direction (neither perpendicular nor parallel) relative to another entity.
An orientation quality inhering in a bearer by virtue of the bearer having a position that is directed anteromedially.
An elevation quality inhering in a bearer by virtue the bearer's being in a high position relative to another entity.
A positional quality inhering in a bearer by virtue of the bearer being hidden from view or covered by another entity.
A shape quality inhering in a bearer by virtue of the bearer's similarity to the appearance of a saddle.
A positional quality inhering in a bearer by virtue of the bearer being level or even with another surface.
A structural quality inhering in a bearer by virtue of the bearer's having an open, latticed, or porous structure; used especially of bone.
A shape quality inhering in a bearer by virtue of the bearer being shaped like a scute or an osteoderm.
A shape quality inhering in a bearer by virtue of the bearer's similarity to the appearance of a funnel.
A shape quality inhering in a bearer by virtue of the bearer having an elongate structure, similar to a ridge, that extends longitudinally along an anatomical entity.
A positional quality inhering in a bearer by virtue of the bearer's being located at a right angle relative to another entity and to the horizon.
An orientation quality inhering in a bearer by virtue of the bearer having a position that is directed mesiolaterally.
A structural quality inhering in a bearer by virtue of the bearer being in a position that produces a separation in, or acting to separate, another entity.
An orientation quality inhering in a bearer by virtue of the bearer having a position that is directed anterodistally.
An orientation quality inhering in a bearer by virtue of the bearer having a position that is directed posterodistally.
obsoleted because the ID was accidentally reused
A multipartite quality inhering in a bearer by virtue of the bearer being divided into two parts.
A shape quality inhering in a bearer by virtue of the bearer's being shaped like a plowshare.
A shape quality inhering in a bearer by virtue of the bearer's having a short and stout cylindrical shape.
A shape quality inhering in a bearer by virtue of the bearer's having a shape like a boomerang, with two arms connected at an angle.
A spheroid quality inhering in a bearer by virtue of the bearer's exhibiting a shape not quite ovoid. approximately ovoid.
A shape quality that obtains by virtue of the bearer being concave on one side and convex on the other.
A shape quality inhering in a bearer by virtue of the bearer's having a shape like a ring (a circular shape enclosing a space).
A shape quality inhering in a bearer by virtue of the bearer's possessing a small, spike-like shape.
Pertaining to the ability or tendency of an organism or cell to maintain internal equilibrium by adjusting its physiological processes.
An intensity which is borderline in it its effect or force as compared to baseline or normal.
An intensity which is characterized by being very severe.
An occurrence quality inhering in a bearer by virtue of the bearer's having a course that occurs occasionally.
An occurrence of a process during which time there is an inability to change the course, extent, or repetition of the process.
A quality in which the effect or outcome is not primary or the focus of the observation.
A variability quality inhering in the bearer by virtue of the bearer having a variable number or count of an entity.
Having the shape of a pear; tapering near the top and bulging toward the base or bottom. From thefreedictionary.com
A quality inhering in a bearer by virtue of the bearer's resembling the form of a paddle.
Shape quality inhering in a bearer expanding outward, or having parts expanding outward, from a center point.
A morphology quality inhering in a bearer by virtue of the bearer's being morphologically distinguishable from another entity.
A 3-D shape inhering in a bearer by virtue of the bearer's having dentition characterized by high-crowned teeth and enamel which extends far past the gum line, which provides extra material for wear and tear.
Need to include axiom: hypsodont inheres_in some ('tooth crown' and bearer_of 'increased height').
A 3-D shape inhering in a bearer by virtue of the bearer's having dentition characterized by low-crowned teeth. Human teeth are brachydont.
Need to include axiom: brachydont inheres_in some ('tooth crown' and bearer_of 'decreased height').
A 3-D shape inhering in a bearer by virtue of the bearer's having an entity in the form of a molar tooth.
A branched quality inhering in a bearer by virtue of the bearer's having many fine filaments or branches that give a feathery appearance: for example, resembling a feather.
A positional quality inhering in a bearer by virtue of the bearer possessing an uninterrupted or unbroken connection or spatial distribution relative to the position of another entity.
A structural quality inhering in a bearer by virtue of the bearer being fully formed compared to entities lacking parts.
A structural quality inhering in a bearer by virtue of the bearer's lacking parts or having a reduced form compared to fully formed entities.
A spheroid shape quality inhering in a bearer by virtue of the bearer's being nearly, but not perfectly, spherical.
A size quality inhering in an entity or set of entities in which size increases or decreases along the extent of the entity or set.
A positional quality inhering in a bearer by virtue of the bearer's being enclosed on all sides by another entity.
A quality inhering in a bearer by virtue of the bearer's being compressed from the side facing the lips to the side facing the tongue.
A quality inhering in a bearer by virtue of the bearer's being compressed from the side facing the midline of the jaw to the side opposite the midline.
A curvature quality inhering in a bearer by virtue of the bearer's being curved towards the tongue.
A shape quality inhering on a bearer by virtue of a bearer's shape lacking in pattern or uniformity; for example, it may have sides of different lengths, different curvatures, or unequal angles.
Cuspidate quality inhering in a bearer by virtue of the bearer's possessing a single cusp.
A diameter that remains constant throughout the extent of an entity.
An orientation quality inhering in a bearer by virtue of the bearer having a position that is in the parasagittal plane.
An orientation quality inhering in a bearer by virtue of the bearer having a position that is directed along the longitudinal or anterior-posterior axis.
A structural quality inhering in the bearer by virtue of the bearer consisting of a single, maximally connected structure.
What counts as maximally connected may be relative to some specification of granularity.
A structural quality inhering in the bearer by virtue of the bearer consisting of multiple structures lacking any physical connection to each other.
The velocity of spatial propagation of a process. Examples include the velocity of propagation of an action potential along an axon.
A propagation velocity that is higher than normal.
A propagation velocity that is lower than normal.
A physical quality of a process that is its spatial distribution. For example, bone mineralization follows stereotypical spatial distribution patterns during development, which may be altered in some phenotypes.
A quality of a single cell inhering in the bearer by virtue of the bearer's size or shape or structure.
Use this term for morphologies that can *only* inhere in a cell, e.g. morphological qualities inhering in a cell by virtue of the presence, location or shape of one or more cell parts.
A cellular quality inhering in a bearer by virtue of the bearer's having multiple cilia.
A cellular quality inhering in a bearer by virtue of the bearer's having only one cilium.
The ability of a process to produce its output.
A decrease in the ability of a process to produce its output.
A increase in the ability of a process to produce its output.
A quality inhering in a structure by virtue of it consisting of many of repeated, similar or identical subunits, arranged in some orderly array.
A complete coverage of this domain would subclasses homopolymeric, copolymeric, crystalline.
A quality inhering in a bearer by virtue of the degree to which the bearers stands out or projects beyond a surface or line.
A quality inhering in a bearer by virtue of the extent to which the bearer is capable of being stretched or swollen.
A quality inhering in air by virtue of the partial pressure exerted by the bearer's water vapour content.
A physical quality inhering in a bearer by virtue of the bearer's exhibiting the physical characteristics of an entity consisting of roughly equal proportions of positively and negatively charged particles, having neither a defined volume nor defined shape, having internal magnetic fields, and being electrically conductive.
The degree to which the bearer is exposed to visible light.
Having a shape or form that resembles a step of a stairway (e.g., a ledge or offset margin).
A physical quality inhering in an entity by virtue of a portion of the bearer's molecular or polymolecular constituents present in one phase being dispersed in a portion of the bearer's constituents present in another phase.
A physical quality inhering in an entity by virtue of the bearer's solid or liquid constituents being suspended in a gas.
A concave 3-D shape quality inhering in a bearer by virtue of the bearer's being shaped in the form of the letter C.
A concave 3-D shape quality inhering in a bearer by virtue of the bearer's being shaped in the form of the letter J.
The propensity of a material to undergo combustion. Combustion encompasses smouldering and flaming combustion. Combustibility is usually applied to solids.
quality, state, or degree of being stable.
A physical quality inhering in an entity by virtue of the bearer's solid or liquid constituents being transiently dispersed in a solid, liquid, or gas before settling due to gravity or centrifugal forces.
A shape that ineres in a bearer by virtue of the bearer's mass being distributed in a feather-like fashion.
The presence of a constituent, impurity, or some other undesirable element that spoils, corrupts, infects, makes unfit, or makes inferior a material, physical body, natural environment, place of human occupancy, or other material entity.
A biological sex quality inhering in an individual based upon genotypic composition of sex chromosomes.
Note that the chromosomal constitution of genotypic sex varies in different organisms. In human, we have XY, XX, though abnormal XXY, X0, XYY, and other combinations are possible.
A biological sex quality inhering in an individual based upon genotypic composition that confers the capability for an organism to differentiate male gonads.
Note that the chromosomal constitution of genotypic sex varies in different organisms. In human, this would be XY, though abnormal XXY and XYY would also result in a male phenotypic outcome.
A biological sex quality inhering in an individual or a population based upon genotypic composition that confers the capability for an organism to differentiate female gonads.
Note that the chromosomal constitution of genotypic sex varies in different organisms. In human, this would be XX, though abnormal X0 and XXX would also result in a female phenotypic outcome.
A physical quality inhering in a bearer by virtue of the bearer's disposition to being fit to be used as a safe means of hydration.
A physical quality inhering in a bearer by virtue of the bearer not being suitable for use as a safe means of hydration.
A physical quality inhering in a bearer by virtue of the bearer being suitable for use as a safe means of hydration.
A malformed quality inhering in a bearer by virtue of the bearer's gross morphology containing what are normally anterior structures and missing some or all of what are normally posterior structures.
A malformed quality inhering in a bearer by virtue of the bearer's gross morphology containing what are normally dorsal structures and missing some or all of what are normally ventral structures.
A malformed quality inhering in a bearer by virtue of the bearer's gross morphology containing what are normally posterior structures and missing some or all of what are normally anterior structures.
A malformed quality inhering in a bearer by virtue of the bearer's gross morphology containing what are normally ventral structures and missing some or all of what are normally dorsal structures.
An anteriorized quality inhering in a bearer by virtue of the bearer's gross morphology containing what are normally anterior structures and missing some but not all of what are normally posterior structures.
A dorsalized quality inhering in a bearer by virtue of the bearer's gross morphology containing what are normally dorsal structures and missing some but not all of what are normally ventral structures.
A posteriorized quality inhering in a bearer by virtue of the bearer's gross morphology containing what are normally posterior structures and missing some but not all of what are normally anterior structures.
A ventralized quality inhering in a bearer by virtue of the bearer's gross morphology containing what are normally ventral structures and missing some but not all of what are normally dorsal structures.
A malformed quality inhering in a bearer by virtue of the bearer's gross morphology containing what are normally dorso-anterior structures and missing some or all of what are normally ventro-posterior structures.
A dorso-anteriorized quality inhering in a bearer by virtue of the bearer's gross morphology containing what are normally dorso-anterior structures and missing some but not all of what are normally ventro-posterior structures.
A dorso-anteriorized quality inhering in a bearer by virtue of the bearer's gross morphology containing only what are normally dorso-anterior structures.
A malformed quality inhering in a bearer by virtue of the bearer's gross morphology containing what are normally ventro-posterior structures and missing some or all of what are normally dorso-anterior structures.
A ventro-posteriorized quality inhering in a bearer by virtue of the bearer's gross morphology containing what are normally ventro-posterior structures and missing some but not all of what are normally dorso-anterior structures.
A ventro-posteriorized quality inhering in a bearer by virtue of the bearer's gross morphology containing only what are normally ventro-posterior structures.
An oriented quality inhering in a bearer by virtue of the bearer's being abnormally placed or arranged.
A positional quality inhering in a bearer by virtue of some aspect of that bearer beginning from a position on another entity.
Original label "originates from" changed to current label to differentiate that this term is a positional quality rather than one that connects between an entity and another entity it originates from.
The ability of a pathogen to produce an infectious disease or disorder in an another organism.
A texture quality inhering in a bearer by virtue of the bearer's being covered or partially covered with hair that has increased thickness and softness.
An orientation quality inhering in a bearer by virtue of the bearer having a position that is directed posteroventrally.
A shape quality inhering in a bearer by virtue of the bearer's having a shape like a crown.
A shape quality inhering in a bearer by virtue of the bearer's having a shape like a shell.
A shape quality inhering in a bearer by virtue of the bearer's having an ornamental border consisting of short straight or twisted threads or strips hanging from cut or raveled edges or from a separate band.
A concave 3-D shape quality inhering in a bearer by virtue of the bearer's being shaped in the form of a bowl.
For example, distinct anteroposterior mobility of palatine relative to mesethmoid.
For example: distinct anteroposterior immobility of palatine relative to mesethmoid.
A shape that is in the form of a plug, being tube-like and expanded on one end.
An orientation quality inhering in a bearer by virtue of the bearer having a position that is directed dorsomedially.
A shape that is in the form of a narrow strip encircling an object.
A concave 3-D shape quality inhering in a bearer by virtue of the bearer's shape resembling that of a trough, being narrow, long, and boxlike in shape.
A shape quality inhering in a bearer by virtue of the bearer's having five angles and five sides.
A growth quality of occurrent in which the growth of an organism, structure or group of organisms is abnormal.
Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue in a reparative or reactive process.
Female quality of being incapable to reproduce because of functional loss of the ovaries and/or uterus from surgical removal.
The bearer of this quality has_part n=1 of the indicated entity type, where n is bilaterally paired for a comparable organism..
A shape quality inhering in a bearer by virtue of the bearer being expanded laterally and or opened outward in shape.
An orientation quality inhering in a bearer by virtue of the bearer having a position that is directed distomedially, ie, pertaining to an inside aspect, but also farther away from the center of the body.
The bearer of this quality has_part n=2 of the indicated entity type, where n is unpaired for a comparable organism.
A structural quality which is held by a bearer where a localized pathological or traumatic structural change, damage, deformity, or discontinuity of tissue, organ, or body part is present.
A structural quality inhering in a bearer by virtue of the bearer's being marked by interruptions or gaps.
This term is intended for use for terms such as MP:0010461 discontinuous pulmonary artery and MP:0004157 interrupted aortic arch.
A ploidy quality inhering in a bearer by virtue of the bearer's haploid cells undergo chromosome doubling.
An organismal quality of having successfully reproduced.
A physical quality inhering in a bearer by virtue of that bearer being shielded from visible light.
Shaded does not refer to radiation more generally, as this would be more shielded than shaded.
A width and length quality which is relatively small, where both width and length are decreased.
A width and length quality that is relatively large, where both width and length are increased.
A distance traveled in a specific time that is relatively high.
A distance traveled in a specific time that is relatively low.
A broken quality where an entity is cracked or broken, usually a bone.
A fractured quality where the fracture traverses the bone perpendicular to the axis of the bone.
A fractured quality in which one of the fragments is driven into another fragment.
A fractured quality where the fracture runs parallel to the long axis of a bone.
A fractured quality where the fracture occurs at a plane oblique to the long axis of the bone.
A fractured quality that occurs when torque (a rotating force) is applied along the axis of a bone.
A fractured quality that is caused by a loss of bone mass (osteoporosis) that occurs as part of aging.
A fractured quality in which the fragment of bone tears away from the main mass of bone as a result of physical trauma.
A decreased quality inhering in a bearer by virtue of the bearer's decreased magnitude in proportion to the magnitude of another entity.
Example: decreased proportion of CD4 T cells relative to total T cells.
An increased quality inhering in a bearer by virtue of the bearer's increased magnitude in proportion to the magnitude of another entity.
Example: increased proportion of CD4 T cells relative to total T cells.
A structural quality inhering in a bearer by virtue of the bearer's components being torn, typically used for soft tissues or membranes.
The rate or speed of the change in in number of a population.
The rate or speed of the change in size of an individual entity.
Existing or functioning as though broken into separate parts; disorganized; disunified.
Moved to a child of wholeness because broken implies a trauma and fragmented could be caused by a developmental process. See HP:0100168 Fragmented epiphyses as an example.
Red due to increase blood circulation in a defined area.
A biological sex quality inhering in an individual or a population who are otherwise male of a non-hermaphroditic species who has ambiguous or atypical congenital development of the reproductive system.
male with differences of sexual differentiation
male with disorder of sexual development
The term intersex is popular in use, but may be considered offensive when applied to humans. DSD can be expanded multiple ways to 'disorders/differences of sexual development/differentiation'.
A phenotypic sex quality inhering in a plant organism or a population of plants in which the flowers have two stamens.
A phenotypic sex quality inhering in a plant organism or a population of plants in which the flowers have only one stamen.
A sequential hermaphroditic quality whereby organisms start out as female and change to male at a later life stage.
A sequential hermaphroditic quality whereby organisms start out as male and change to female at a later life stage.
A protogynous quality whereby organisms start out as female and change to hermaphrodite at a later life stage.
A protandrous quality whereby organisms start out as male and change to hermaphrodite at a later life stage.
A biological sex quality inhering in an individual or a population who are otherwise female of a non-hermaphroditic species who has ambiguous or atypical congenital development of the reproductive system.
female with differences of sexual differentiation
female with disorder of sexual development
A quality inhering in a process by virtue of that process having a population or part of a population, where population is defined as a collection of individuals from the same taxonomic class distinguished by one or more characteristics, as participants.
A quality denoting the lack of a physical entity or object, such as a chemical.
A quality denoting the lack of a process or function.
A quality denoting the lack of an anatomical entity or cellular component.
Absence of anatomical entity should only be used when all of the entity is absent. For example, absent teeth would mean all teeth are absent not some teeth are absent.
A physical quality inhering in a bearer by virtue of the bearer's disposition to deform by heating.
A quality inhering in a cell by virtue of the ratio between the volume of its nucleus and the volume of its cytoplasm.
A quality inhering in a cell by virtue of the cell having a high nuclear/cytoplasmic ratio.
A high nuclear/cytolasmic ratio is 70% or higher.
A quality of an object that has a value that is normal or average.
A adhesivity which is relatively normal or average.
An affinity which is relatively normal or average.
An age which is relatively normal or average.
An avidity which is relatively normal or average.
A behavioural quality of a process inhering in a bearer by virtue of the bearer's exhibiting normal or average activity.
A cellular motility which is normal or average.
A concentration which is relatively normal or average.
A contractility which is relatively normal or average.
A coordination which is relatively normal or average.
A curvature which is relatively normal or average.
A distance which is relatively normal or average.
An efficiency which is relatively normal or average.
An elasticity which is relatively normal or average.
A fecundity which is relatively normal or average.
A female fertility which is relatively normal or average.
A female receptivity which is relatively normal or average.
A fertility which is relatively normal or average.
A flexibility which is relatively normal or average.
A fluid flow which is relatively normal or average.
A fluorescence which is relatively normal or average.
A force which is relatively normal or average.
A fragility which is relatively normal or average.
A life span which is relatively normal or average.
A magnetism which is relatively normal or average.
A male fertility which is relatively normal or average.
A male receptivity which is relatively normal or average.
A mass which is relatively normal or average.
A density which is relatively normal or average.
A mobility which is relatively normal or average.
An odor quality of having relatively normal or average odor.
An osmolality which is relatively normal or average odor.
An osmolarity which is relatively normal or average odor.
A permeability which is relatively normal or average.
A quality inhering in a bearer by virtue of the bearer's being phosphorylated to a normal or average extent.
A photosensitivity which is relatively normal or average
A degree of pigmentation quality which is relatively normal or average
A position which is relatively normal or average
An angle which is relatively normal or average
A distribution which is relatively normal or average
An elevation which is relatively normal or average
A pressure which is relatively normal or average
A radioactivity which is relatively normal or average
A radiopacity which is relatively normal or average
A resistance to a stimulus which is relatively normal or average
A sensitivity to irradiation which is relatively normal or average
A sensitivity toward an external stimulus which is relatively normal or average
A size quality which is relatively normal or average
An area which is relatively normal or average
A depth quality which is relatively normal or average
A height which is relatively normal or average
A length quality which is relatively normal or average
A diameter which is relatively normal or average
An anterior-posterior diameter which is relatively normal or average
A perimeter which is relatively normal or average
A circumference which is relatively normal or average
A thickness which is relatively normal or average
A volume which is relatively normal or average
A width which is relatively normal or average
A solubility which is relatively normal or average
A speed which is relatively normal or average
A strength which is relatively normal or average
A fatigability which is relatively normal or average
A susceptibility toward an external stimulus which is relatively normal or average
A temperature which is relatively normal or average
A tendency which is relatively normal or average
A threshold which is relatively normal or average
A tolerance to an external stimulus which is relatively normal or average
A tonicity which is relatively normal or average
A turgor which is relatively normal or average
A quality of a process that has a value that is normal or average.
A variability which is relatively normal or average
A variability of color which is relatively normal or average
A variability of rate which is relatively normal or average
A variability of size which is relatively normal or average
A variability of temperature which is relatively normal or average
A velocity which is relatively normal or average
A virulence which is relatively normal or average
A viscosity which is relatively normal or average
A waxiness which is relatively normal or average
A wetness which is relatively normal or average
A duration quality of a process which is relatively normal.
A duration quality of temperature quality of a process which is relatively normal.
An occurrence which is relatively normal.
A sensitivity of a process which is relatively normal.
A sensitivity of occurrent to oxygen which is relatively normal.
normal sensitivity of a process to oxygen
The four cardinal directions or cardinal points are the directions north, east, south, and west, commonly denoted by their initials, N, E, S, W. East and west are at right angles to north and south, with east being in the clockwise direction of rotation from north and west being directly opposite east.
North is one of the four compass points or cardinal directions. It is the opposite of south and is perpendicular to east and west.
East is one of the four cardinal directions or points of the compass. It is the opposite direction from west.
South is one of the four cardinal directions or compass points. South is the polar opposite of north and is perpendicular to east and west.
West is one of the four cardinal directions or points of the compass. It is the opposite direction from east.
The number of repeated events per unit time, occurring in a repeating series. (e.g. the number of heart beats occurring over 1 minute)
The rate of output of a continuous process. Example include: growth rate, cell migration rate, enzyme reaction rate.
A spatial distribution of a process in which the process occupies a smaller length, area, or volume than the reference process. For example, heterochromatin may form over a shorter length of a chromosome in a mutant than in wild type.
A spatial distribution of a process in which the process occupies a greater length, area, or volume than the reference process. For example, heterochromatin may form over a shorter length of a chromosome in a mutant than in wild type.
A rate of occurrence that is relatively high.
A rate of occurrence that is relatively low.
A rate of output of a continuous process that is relatively high.
A rate of output of a continuous process that is relatively low.
A quality inhering in a bearer by virtue of the bearer's being present in one sex and absent from the other in members of the same species.
A quality inhering in a bearer by virtue of the bearer's being present in males and absent from females in members of the same species.
A quality inhering in a bearer by virtue of the bearer's being present in females and absent from males in members of the same species.
The breakdown, disintegration, destruction of an entity due to the breaking of cell membranes by any means.
A degree of pigmentation quality that is diversified with patches, or irregularity.
A hermaphroditic quality that inheres in a population or organism where an organism changes is a different sexes during different life stages.
Sequential hermaphrodity is generally characterized by an organism producing female gametes and male gametes during different life stages.
A cell morphology that inheres in neurons which have a small round soma, a large number of short, smooth, or slightly beaded primary dendrites that give rise to only a few secondary branches, and a branched axon that establishes a dense axonal mesh with thin shafts.
A cell morphology that inheres in multipolar neurons with densely branched terminal axonal arborizations that form basket-like structures surrounding and synapsing to the somas of target cells.
A basket cell morphology that inheres in neurons with axonal arbors composed of frequent, short, curvy axonal branches that tend to be near their somata and within the same layer.
A basket cell morphology that inheres in neurons that are large, and typically ascend to give rise to many long horizontally and vertically projecting axon collaterals that traverse neighboring columns and can extend through all cortical layers.
A basket cell morphology that inheres in neurons which have simpler dendritic arbors (compared to small or large basket cell morphology), and an axonal plexus of intermediate density, composed of a few long, smooth axonal branches.
A cell morphology that inheres in neurons which have two principal dendrites that emerge from the soma and begin to branch some distance from it, have few spines, and branch in narrow fields. This is in contrast to bitufted morphology where branching occurs close to the soma.
This is specific to cortical bipolar cells and are distinguished from retinal bipolar cell morphology which has an axon and dendrite emerging from opposite ends of the soma.
A cell morphology that inheres in neurons which are large and non-spiny, with dendrites radiating in a multipolar or bitufted pattern, often favouring the descending side, and axons that ascend directly from the superficial side of the soma, and travel upward without branching.
A Martinotti cell morphology that inheres in neurons which have axons that form a horizontal ramification, making it T-shaped.
A Martinotti cell morphology that inheres in neurons which have axons that form a fan-like plexus.
A cell morphology that inheres in neurons that have dendritic processes radiating from the cell body forming a star-like shape.
A cell morphology that inheres in neurons which are small and round, and make highly specialized synapses with the axon initial segments of pyramidal neurons, wrapping them with candle-shaped synaptic 'cartridges'.
Chandelier cells can be bitufted or multipolar.
A cell morphology that inheres in neurons which have two clusters of primary dendrites that originate directly and extend from opposite ends of the soma, and axons that form a plexus which spreads widely. Compared to the narrow vertical axonal projection of bipolar morphology, and the 'horse-tail' axonal cluster of double boquet cells, bitufted morphology has wide horizontal axonal spans, and branching that occur close to the soma. Their vertical projection is also less extensive and crosses mostly to neighboring layers.
A cell morphology that inheres in neurons which have spiny basal dendrites and resemble pyramidal cells but lose their apical dendrites as they mature. Their axons nearly always emerge from the descending side of the soma, but often recurve and ascend with arc-like collaterals.
A cell morphology that inheres in neurons which have a pyramidal shaped soma, a single axon, a large apical dendrite and multiple basal dendrites.
A pyramidal family morphology that inheres in neurons which have an apical tree which is oriented parallel to the pia.
A pyramidal family morphology that inheres in neurons which have a standard pyramidal shape with its apical dendrite aligned vertically.
A pyramidal cell morphology that inheres in neurons which have a distinct tuft formation, distal from the soma.
A pyramidal cell morphology that inheres in neurons which lack a clear tuft formation but extend to large radial distances.
A pyramidal cell morphology that inheres in neurons which lack a tuft formation but extend to small radial distances forming a star-like shape.
A pyramidal cell morphology that inheres in neurons which have an apical tree which is oriented towards the white matter.
A cell morphology that inheres in neurons with only one process, a neurite, that extends from the cell body. The neurite then branches to form dendritic and axonal processes.
A cell morphology that inheres in neurons which possess three or more neurites, usually a single axon and many dendrites and dendritic branches.
A cell morphology that inheres in neurons with dendrites that are bidirectional, emerging from opposite ends of the soma, with the two arbors extending in radial or tangential directions.
This morphology type is distinct from bitufted cell morphology in that it refers to bitufted dendrite morphology rather than bitufted cell morphology.
A neuron projection quality that is a characteristic of neurons whose soma is located in the telencephalon and that project to structures outside the telencephalon
A neuron projection quality that is a characteristic of neurons with soma in the cerebral cortex and projections to the thalamus.
A neuron projection quality that is a characteristic of neurons with projections that terminate locally rather than distantly.
A neuron projection quality that is a characteristic of neurons that project to the medulla oblongata from other brain regions.
A physical quality inhering in a neuron by virtue of the relative location of its soma and the regions to which it projects and makes synaptic contacts in.
A neuron projection quality that is a characteristic of neurons with both soma and projections entirely within the telencephalon.
A quality inhering in a neuron's dendrites by virtue of the bearer's physical composition.
A dendrite quality inhering in a neuron by virtue of the bearer's dendrite having spines.
A dendrite quality inhering in a neuron by virtue of the bearer's dendrite having a terminal tuft.
A dendrite quality inhering in a neuron by virtue of the bearer's dendrite having few or no recognizable dendritic spines.
A dendrite quality inhering in a neuron by virtue of the bearer's dendrite having numerous swellings or varicosities along their length.
A cell morphology that inheres in retinal neurons which have two principal fibres, an axon and a dendrite, that emerge from opposite end the soma.
This is distinct from cortical bipolar morphology which has two dendrites emerging from opposite ends of the soma, rather than one axon and one dendrite.
A quality of continuant that exist at the anatomical level of organisation and anything under it. This includes, but is not limited to, cells , tissues, and components.
A quality inhering in an anotomical structure by virtue of its capacity to be stained by specific histological dyes.
An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction that stains and colors, pale-pink, with Wright-Giemsa stain.
An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for both basic and acid stains under specific pH conditions.
A texture quality inhering in a bearer by virtue of the bearer's being covered by iron oxide as a result of oxidation.
A quality of a substance on which or through which electromagnetic radiation impinges or traverses with respect to radiation. This substance quality changes the quality of the incident radiation with respect to any of: intensity, direction, scatter and wavelength.
quality of interaction of a substance with electromagnetic radiation
A cell morphology that inheres in neurons with bitufted dendritic morphology but with the special feature of a tight fascicular axonal cylinder that resembles a 'horse tail'.
A cell morphology that inheres in neurons with dendrites that stratify at two and only two locations.
A cell morphology that inheres in neurons with dendrites that stratify at one and only one location.
A 3-D extent quality inhering in a bearer by virtue of the spatial region that is defined by the maximal span of the bearer's dendritic arbor.
A physical quality inhering in an entity exhibiting the physical charachteristics of a material that flows under applied force.
An osmolarity quality inhering in a bearer by virtue of the total amount of ionic salts dissolved in the bearer.
Quotient (or ratio) of surface area of an organism divided by the mass of the same organism
An organismal quality inhering in a bearer by virtue of the bearer's morphological and physiological adaptation for running.
An organismal quality inhering in a bearer by virtue of the bearer's morphological and physiological adaptation for digging and living underground.
An organismal quality inhering in a bearer by virtue of the bearer's morphological and physiological adaptation for living in trees.
A quality of a process that happens during dawn and dusk.
A quality of a process that happens during the hours of darkness.
A quality of a process that happens during the hours of daylight.
An organismal quality inhering in a bearer by virtue of the bearer's morphological and physiological adaptation for participating in long-distance movement of conspecifics, usually on a seasonal basis.
An organismal quality inhering in a bearer by virtue of the bearer's ability to burrow more than 20 cm deep into the soil and make permanent, vertical burrows.
A quality of an entity that can be represented numerically, including anything that can be counted, measured, or given a numerical value.
A quantitative quality that represents the sum of all 'mass' qualities of the component parts that constitute a whole entity. The total mass quality inheres in the whole entity and reflects the aggregate measure of mass across all its components, such that changes in the mass of individual components may not necessarily correspond to equivalent changes in the total mass of the whole. Example of usage: "total body mass" represents the sum of the masses of all tissues and organs in the body, while "liver mass" represents only the mass of the liver. An increase in liver mass does not necessarily mean an increase in total body mass, as the mass of other organs or tissues may decrease simultaneously.
A total mass which is higher than normal or average.
A total mass which is lower than normal or average.
A quantitative quality that represents the sum of all 'amount' qualities of the component parts that constitute a whole entity. The total amount quality inheres in the whole entity and reflects the aggregate measure across all its components, such that changes in the amount of individual components may not necessarily correspond to equivalent changes in the total amount of the whole. Example of usage: "blood total protein amount" represents the sum of the amounts of all protein types in blood, while "blood leptin amount" represents only the amount of leptin proteins. An increase in blood leptin amount does not necessarily mean an increase in blood total protein amount, as other protein levels may decrease simultaneously.
A total amount which is relatively high.
A material entity that consists of two or more organisms, viruses, or viroids.
May be of the same or different species.
collection of organisms
A collection of organisms, all of the same species, that live in the same place.
It is sometimes difficult to define the physical boundaries of a population. In the case of sexually reproducing organisms, the individuals within a population have the potential to reproduce with one another during the course of their lifetimes. 'Community', as often used to describe a group of humans, is a type of population of organisms. Classes for population already exist in IDO ('organism population', IDO_0000509) and OBI ('population', OBI_0000181). The definitions should be standardized across OBO Foundry ontologies and only one term used.
population of organisms
A multi-species collection of organisms of at least two different species, living in a particular area. Must have at least two populations of different species as members.
Ecological community is defined broadly here, but includes both ecological interactions (inherited from parent term community) and spatial co-existence. It may be used to describe every organisms living in an area, but is often used to refer only to organisms of a particular taxon or guild (e.g., the plant community, the insect community, the herbivore community). The word community, as it often used to describe a group of humans living together, is a type of single-species collection of organisms, not an ecological community.
ecological community
A quality that inheres in a population of organisms.
Includes qualities like population size, population growth rate, carrying capacity, immigration rate, emigration rate, fecundity, and death rate. A population quality may depend on the qualities of individual organisms in the population, but cannot be measured or described for a single organism. This term may be replaced by a PATO term.
quality of a population
A quality that inheres in a community.
Includes qualities like diversity, species richness, stability, resilience, community structure, number of trophic levels. A community quality may depend on the qualities of individual organism in the community, but cannot be measured or described for a single individual.
quality of an ecological community
A material entity that has as parts two or more organisms, viruses, or viroids of the same species and no members of any other species.
single-species collection of organisms
A collection of organisms that consists of two or more organisms from at least two species.
multi-species collection of organisms
A material entity that is one or more organisms, viruses or viroids.
organismal entity
An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof.
The definition above excludes protein complexes, which some also consider a protein. Those who wish to refer to a class representing both senses of the word are directed to CHEBI:36080. Note that the definition allows for experimentally-manipulated genes, and allows for artifically-produced derivatives that mimic those found naturally. Proteins (in the sense defined here) that descended from a common ancestor can be classified into families and superfamilies composed of products of evolutionarily-related genes. The domain architecture of a protein is described by the order of its constituent domains. Proteins with the same domains in the same order are defined as homeomorphic [PRO:WCB).
A protein that is a translation product of the human CD19 gene or a 1:1 ortholog thereof. It is composed of an N-terminal extracellular domain containing two Ig-like C2-type (immunoglobulin-like) domains, followed by a single-pass transmembrane segment and a cytoplasmic C-terminal tail. CD19 expression is restricted to members of the B cell lineage. It functions as a co-receptor for B-cell antigen receptor (BCR), regulating signal transduction.
A protein that is a translation product of the human CD34 gene or a 1:1 ortholog thereof. It is a leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. It contains a single-pass transmembrane domain and that show distinct expression on early hematopoietic precursors and vascular-associated tissue. Acts as a scaffold that presents selectin carbohydrate ligands in a clustered, tissue specific manner to allow for higher avidity interactions between leukocytes and endothelial cells during the inflammatory process. In common with related sialomucins (endoglycan and podocalyxin), the extracellular region is dominated by an N-terminal mucin-like domain, which is densely substituted with sialylated O-linked carbohydrates. The mucin-like region is followed by a cysteine-containing and presumably globular domain. This domain may fold into an immunoglobulin-like structure as the positions of 2 of the cysteines are conserved in the C2 set of the immunoglobulin superfamily. The cytoplasmic domain is around 73-76 residues long and highly conserved.
hematopoietic progenitor cell antigen CD34
A protein that is a translation product of the human CD4 gene or a 1:1 ortholog thereof. CD4 is an accessory protein for MHC class-II antigen/T-cell receptor interaction. It is the primary receptor for HIV-1. CD4 has four immunoglobulin-like domains in its extracellular region that share the same structure, but can differ in sequence.
An integrin alpha that contains an A domain. A hallmark of this class is the presence of a von Willebrand factor type A domain (Pfam:PF00092) (I-domain) of approximately 200 amino acid residues at the N terminus, which confers divalent cation binding properties. Unlike other integrin alpha proteins, they do not undergo proteolytic cleavage.
An integrin alpha with A domain that is a translation product of the human ITGAM gene or a 1:1 ortholog thereof. They constitute subunits of the integrin alpha-M/beta-2 receptor. This receptor is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is also a receptor for fibrinogen, factor X and ICAM1.
cell surface glycoprotein MAC-1 subunit alpha
A protein that has a core domain composition consisting of an extracellular N-terminal domain that adopts an immunoglobulin fold, a transmembrane domain, and an intracellular C-terminal domain with a single copy of the Immunoreceptor tyrosine-based activation motif (Pfam:PF02189) (ITAM). It constitutes the invariant subunit of the T cell antigen receptor (TCR). TCR is a surface receptor on T cells responsible for recognizing MHC-restricted antigens and initiating the cellular immune response.
A CD3 subunit with immunoglobulin domain that is a translation product of the human CD3E gene or a 1:1 ortholog thereof.
T-cell surface antigen T3/Leu-4 epsilon chain
A protein with a domain composition consisting of a large extracellular domain, including five Ig-like C2-type domains followed by two copies of the Fibronectin type-III domain (Pfam:PF00041), a single-pass transmembrane domain and a short cytoplasmic C-terminal domain.
A neural cell adhesion molecule that is involved in neuronal development, synaptic plasticity, and regeneration.
A neural cell adhesion molecule NCAM that is a translation product of the human NCAM1 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human CD2 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human CD8A gene or a 1:1 ortholog thereof. CD8 is a transmembrane that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain.
T-lymphocyte differentiation antigen T8/Leu-2
T-cell surface glycoprotein CD8 alpha chain
A protein that is a translation product of the human MS4A1 gene or a 1:1 ortholog thereof.
membrane-spanning 4-domains subfamily A member 1
A protein that has a core domain structure of signal sequence, propeptide, five Cadherin domains (Pfam:PF00028), a transmembrane region, and a Cadherin cytoplasmic region (Pfam:PF01049). Cadherins function as adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in solid tissues.
A cadherin that is a translation product of the human CDH5 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human CD5 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human IL7R gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human CD14 gene or a 1:1 ortholog thereof.
myeloid cell-specific leucine-rich glycoprotein
A protein that is a translation product of the human TFRC gene or a 1:1 ortholog thereof.
A protein with core architecture consisting of a signal sequence, followed by 7 Ig-like domains (Pfam:PF00047, Pfam:PF07679, or Pfam:PF07686), a transmembrane region, and a cytoplasmic Protein tyrosine kinase domain.
vascular endothelial growth factor receptor
A vascular endothelial growth factor receptor that is a translation product of the human KDR gene or a 1:1 ortholog thereof.
vascular endothelial growth factor receptor 2
A protein that is the translation product of any of the LY6 genes (LY6A-LY6I).
An Ly-6-like protein that is a translation product of the mouse Ly6g gene or a 1:1 ortholog thereof.
A protein that is a translation product of the Ly76 gene in mouse.
Category=organism-gene. Requested by=CL.
A protein that is a translation product of the human FGF8 gene or a 1:1 ortholog thereof.
A protein that is a translation product of the human SHH gene or a 1:1 ortholog thereof.
Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains
A protein that is a translation product of the human TAL1 gene or a 1:1 ortholog thereof.
class A basic helix-loop-helix protein 17
T-cell acute lymphocytic leukemia protein 1
An organic amino compound that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds.
A protein that is composed of a long N-terminal extracellular domain, a transmembrane domain and a short cytoplasmic C-terminal domain. The N-terminal domain contains beta-propeller repeats (interrupted by an A domain in a subset of integrins alpha), while the C-terminal domain contains a GFFxR motif.
Category=family. Integrins are heterodimeric complexes of an alpha and a beta subunit. They are a structurally elaborate family of adhesion molecules that transmit signals bidirectionally across the plasma membrane by undergoing large-scale structural rearrangements. By regulating cell-cell and cell-matrix contacts, integrins participate in a wide-range of biological interactions including development, tissue repair, angiogenesis, inflammation and hemostasis. [PMID:10402956, PMID:11988479, PMID:9676575].
A protein that is encoded in the genome of Mus musculus.
A protein that is encoded in the genome of some Eukaryota.
A molecular entity that minimally consists of a protein.
Note: This includes single proteins and derivatives thereof (PR:000000001), protein-containing complexes (GO:0032991), and protein aggregates (PR:000050565).
A T-cell surface glycoprotein CD8 alpha chain that is encoded in the genome of mouse.
T-cell surface glycoprotein Lyt-2 (mouse)
T-cell surface glycoprotein CD8 alpha chain (mouse)
An integrin alpha-M that is encoded in the genome of mouse.
CD11 antigen-like family member B (mouse)
cell surface glycoprotein MAC-1 subunit alpha (mouse)
A CD4 molecule that is encoded in the genome of mouse.
T-cell differentiation antigen L3T4 (mouse)
A CD2 molecule that is encoded in the genome of mouse.
T-cell surface antigen T11/Leu-5 (mouse)
A CD14 molecule that is encoded in the genome of mouse.
myeloid cell-specific leucine-rich glycoprotein (mouse)
monocyte differentiation antigen CD14 (mouse)
A T-cell surface glycoprotein CD5 that is encoded in the genome of mouse.
A neural cell adhesion molecule 1 that is encoded in the genome of mouse.
An interleukin-7 receptor subunit alpha that is encoded in the genome of mouse.
interleukin-7 receptor subunit alpha (mouse)
A membrane-spanning 4-domains subfamily A member 1 that is encoded in the genome of mouse.
B-cell differentiation antigen Ly-44 (mouse)
membrane-spanning 4-domains subfamily A member 1 (mouse)
A T-cell acute lymphocytic leukemia protein 1 that is encoded in the genome of mouse.
T-cell acute lymphocytic leukemia protein 1 homolog (mouse)
A CD3 epsilon that is encoded in the genome of mouse.
T-cell surface antigen T3/Leu-4 epsilon chain (mouse)
T-cell surface glycoprotein CD3 epsilon chain (mouse)
A CD19 molecule that is encoded in the genome of mouse.
A lymphocyte antigen 6G that is encoded in the genome of mouse.
A vascular endothelial growth factor receptor 2 that is encoded in the genome of mouse.
protein-tyrosine kinase receptor flk-1 (mouse)
vascular endothelial growth factor receptor 2 (mouse)
A fibroblast growth factor 8 that is encoded in the genome of mouse.
A cadherin-5 that is encoded in the genome of mouse.
A sonic hedgehog protein that is encoded in the genome of mouse.
Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains (mouse)
A transferrin receptor protein 1 that is encoded in the genome of mouse.
A CD34 molecule that is encoded in the genome of mouse.
hematopoietic progenitor cell antigen CD34 (mouse)
A material entity consisting of multiple components that are causally integrated.
An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity.
A layer of dense irregular connective tissue that lines organs and supports the mucosa, as well as joins the mucosa to the bulk of underlying smooth muscle. [WP,unvetted].
A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.
The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia[GO].
parasympathetic part of autonomic division of nervous system
Part of peripheral nervous system that includes the somatic parts of the cranial and spinal nerves and their ganglia and the peripheral sensory receptors.
somatic nervous system, somatic division
somatic part of peripheral nervous system
The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter [GO].
sympathetic part of autonomic division of nervous system
Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis.
A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures.
Except in the case of abstracted fiat boundaries such as the midline plane of an organism, all 2D anatomical entities have a 3 dimensional projection. For example, the surface of the shell of a muscle has a distinct shape that projects into the third dimension. Note that boundaries are 2D structures. They have no thickness - and so can not be sites of gene expression or gene product localisation. For this, use boundary region terms.
A light sensing organ composed of ommatidia.
An organ of sight that includes the camera-type eyeball and supporting structures such as the lacrimal apparatus, the conjunctiva, the eyelid.
camera-type eye plus associated structures
An organ that is capable of transducing sensory stimulus to the nervous system.
Appendage that is shaped in order to produce lift for flight through the air.
Any hollow cylindrical anatomical structure containing a lumen through which substances are transported.
Major subdivision of an organism that protrudes from the body[DOS, CARO].
A thin layer of loose connective tissue which lies beneath the epithelium and together with the epithelium constitutes the mucosa[WP]. The lamina propria contains capillaries and a central lacteal (lymph vessel) in the small intestine, as well as lymphoid tissue. Lamina propria also contains glands with the ducts opening on to the mucosal epithelium, that secrete mucus and serous secretions.
A lamina propria that is part of a respiratory airway.
The head is the anterior-most division of the body [GO].
Multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer.
Dense regular connective tissue that connects muscle to bone[VSAO].
A biological tissue mass, most commonly a mass of nerve cell bodies.
An eye with one concave chamber. Note that 'simple' does not imply a reduced level of complexity or acuity.
A tubular structure that contains, conveys body fluid, such as blood or lymph.
A tubular structure that transports secreted or excreted substances.
Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers.
Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome.
Anatomical structure that performs a specific function or group of functions [WP].
A part of an organ that constitutes a distinct modular sub-unit. In some cases, the organ may also contain other sub-units of identical or similar types, in other cases this may be a distinct entity.
A multicellular structure that is a part of an organ.
Anatomical structure that is part of the respiratory system. In mammals consists of upper and lower tracts.
The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage.
A life cycle stage that starts with fertilization and ends with the fully formed embryo.
proximo-distal subdivision of respiratory tract
Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS.
Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism.
The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm.
An anatomical structure that develops from the endoderm and the mesoderm.
mixed endoderm/mesoderm-derived structure
An anatomical structure that develops from the ectoderm, mesoderm and endoderm.
mixed ectoderm/mesoderm/endoderm-derived structure
A spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum.
A glycoprotein membrane surrounding the plasma membrane of an oocyte. It is a vital constitutive part of the latter, external but not extraneous to it. The zona pellucida first appears in multilaminar primary oocytes.
A mass of cells that develop into the body of the embryo and some extraembryonic tissues.
The mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta.
Aggregate of cells forming the outer layer of a blastocyst, which provide nutrients to the embryo and develop into a large part of the placenta. They are formed during the first stage of pregnancy and are the first cells to differentiate from the fertilized egg. [Wikipedia:Trophoblast]
A flattened, almost circular bilaminar plate of cells formed when the inner cell mass (aka embryoblast) forms two epithelial layers, each of a distinct lineage, separated by an extracellular basement membrane: the external (dorsal) layer is called the epiblast and the internal (ventral) layer is called the hypoblast (aka primitive endoderm); together, they compose the bilaminar embryonic disc.
Stage succeeding embryo, including mature structure.
Nonparenchymatous organ that primarily consists of dense connective tissue organized into a sheet which interconnects two or more organs, separates two or more body spaces from one another, or surrounds an organ or body part. Examples: interosseous membrane of forearm, obturator membrane, tympanic membrane, fibrous pericardium, fascia lata, dura mater. [FMA].
Portion of neural crest that develops from the dorsal neural tube. It overlaps the vagal neural crest and migrates to populate the pharyngeal arches 3, 4 and 6 (producing structures in the head) and to the heart, forming connective tissue that separates the great vessels of the heart. [Wikipedia].
The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs[GO].
An entire span of an organism's life. In metazoans, commences with the zygote stage and ends with the death of the organism.
A spatiotemporal region encompassing some part of the life cycle of an organism.
A stage at which the organism is a single cell produced by means of sexual reproduction.
The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula.
An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence.
A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
A chordate developmental stage defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.
A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism.
The connective tissue located between the respiratory (airway and alveolar) epithelium, the capillary endothelium and pleural mesothelium; it contains basement membrane composed of collagen, elastin, proteoglycans, and fibronectin.
A tube in the respiratory system. Examples: bronchus, bronchiole, trachea.
Structure derived from foregut that becomes a lung[GO].
A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses.
A spatially aggregated collection of nerve cell bodies in the CNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections, and including nearby cells that share the same cell type, chemical phenotype, and connections. (CUMBO).
Nucleus that receives projections from or contains neurons that send projections through one of the cranial nerves.
Anatomical conduit that connects two adjacent body spaces (or a body space with the space surrounding the organism)[FMA,modified].
The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks).
The orifice that connects the mouth to the exterior of the body.
Anatomical cavity at the start of the digestive tract that that is enclosed by the mouth. The boundaries and contents vary depending on the species. In vertebrates, the boundaries are the oral opening, the cheeks, the palate and (if present) the palatoglossal arch - if this is not present then the mouth and pharynx form the oropharyngeal cavity. The buccal cavity contains the teeth, tongue and palate (when present).
The pair of anatomical structures comprised of a left lung and right lung.
Organ that functions in gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms.
A fluid that is composed of blood plasma and erythrocytes.
Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs.
Dorsal part (roof region) of the telencephalon[GO].
A layer of membrane around a tendon. It has 2 layers: synovial sheath + fibrous tendon sheath.
Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence.
The branched tubular glands found in the mucosa of the fundus and body of the stomach which contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin.
The wall of the digestive tract. This encompasses all parts of the digestive tract with the exception of the lumen (cavity).
Bone marrow in which the fat cells predominate in the meshes of the reticular network.
A lining of mostly endodermal origin, covered in epithelium, which is involved in absorption and secretion. They line various body cavities that are exposed to the external environment and internal organs. It is at several places continuous with skin: at the nostrils, the lips, the ears, the genital area, and the anus. The sticky, thick fluid secreted by the mucous membranes and gland is termed mucus. The term mucous membrane refers to where they are found in the body and not every mucous membrane secretes mucus[WP].
Functional part of an organ in the body. This is in contrast to the stroma, which refers to the structural tissue of organs, being exactly, connective tissues.
A mucosa that is part of a pharynx [Automatically generated definition].
The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm[GO].
The red vascular substance consisting of connective tissue and blood vessels, containing primitive blood cells, macrophages, megakaryocytes, and fat cells. Red marrow is found in the cavities of many bones. It manufactures and releases leukocytes and erythrocytes into the bloodstream.
Extraembryonic cells of trophoblastic shell surrounding embryo, outside the cytotrophoblast layer, involved with implantation of the blastocyst by eroding extracellular matrix surrounding maternal endometrial cells at site of implantation, also contribute to villi. (dark staining, multinucleated).
The motor and sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the auricle, the external acoustic meatus, tympanic membrane, temporal region, the cheek, the skin overlying the mandible, the anterior portion of the tongue, the floor of the mouth, lower teeth and gingiva and transmits motor information from the muscles of mastication, the mylohyoid muscle and digastric muscle and the muscles tensor tympani and tensor veli palatini.
mandibular division of fifth cranial nerve
mandibular division of trigeminal nerve [Vc; V3]
The sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the palate, upper teeth and gingiva, the skin between the palpebral fissure and the mouth, and from the nasal cavity and maxillary sinuses.
maxillary division of fifth cranial nerve
maxillary division of trigeminal nerve (Vb; V2)
A mucosa that is part of a respiratory airway.
The subdivision of the musculoskeletal system that consists of all the muscles of the body[VSAO, modified].
The core of the crystalline lens, surrounded by the cortex.
A gland in which the principal secretory cells are serous secreting cells.
A mucosa that is part of a bronchus [Automatically generated definition].
An anatomical wall that is part of an artery [Automatically generated definition].
A portion of organism substance that is produced by exocrine glands.
Any of several small branches of the internal carotid artery that supply the trigeminal ganglion and the walls of the cavernous and petrosal sinuses.
cavernous branch of cavernous part of internal carotid artery
Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body.
Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures.
Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function.
Anatomical structure that is an individual member of a species and consists of more than one cell.
The organs and associated structures associated with bearing offspring in a female animal.
Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument.
Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue.
Anatomical group whose component anatomical structures lie in close proximity to each other.
A multicellular anatomical structure that is associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis.
see also conceptus extraembryonic component in EHDAA2.
Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation.
Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types.
Acellular anatomical structure that consists of a thin sheet of fibrous proteins that underlie and support the cells of an epithelium. It separates the cells of an epithelium from any underlying tissue.
Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO].
Editor note: surface epithelium may contain non-epithelial cells, such as melanocytes, lymphocytes and dendritic cells, within the sheet of epithelial cells. Do we consider these part of the epithelium, or located-in it?
Unilaminar epithelium that consists of a single layer of cuboidal cells.
Unilaminar epithelium, which consists of a single layer of columnar cells. Examples: ciliated columnar epithelium, gastric epithelium, microvillus columnar epithelium.[FMA].
Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA].
Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA].
Epithelium that consists of epithelial cells not arranged in one ore more layers.
Compound organ that contains one or more macroscopic anatomical spaces.
Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA].
Subdivision of trunk that lies between the head and the abdomen.
The subdivision of the vertebrate body between the thorax and pelvis. The ventral part of the abdomen contains the abdominal cavity and visceral organs. The dorsal part includes the abdominal section of the vertebral column.
Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm.
Classically the germ layers are ectoderm, mesoderm and endoderm. Alternatively: primary = ectoderm, endoderm; secondary=mesoderm; tertiary=dorsal mesoderm, NC[https://github.com/obophenotype/uberon/wiki/The-neural-crest]
Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue.
Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut.
The middle germ layer of the embryo, between the endoderm and ectoderm.
Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity.
An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium.
The main trunk of the systemic arterial system that carries blood from the heart to all the organs and other structures of the body, bringing oxygenated blood to all parts of the body in the systemic circulation.
A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ.
Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" DOI:10.1101/gad.1485706
Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity.
The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP].
The thin layer of gray matter on the surface of the cerebral hemisphere that develops from the telencephalon. It consists of the neocortex (6 layered cortex or isocortex), the hippocampal formation and the olfactory cortex.
The cervical nerves are the spinal nerves from the cervical vertebrae. Although there are seven cervical vertebrae (C1-C7), there are eight cervical nerves (C1-C8). All nerves except C8 emerge above their corresponding vertebrae, while the C8 nerve emerges below the C7 vertebra. (In the other portions of the spine, the nerve emerges below the vertebra with the same name. Dorsal (posterior) distribution includes the greater occipital (C2) and third occipital (C3). Ventral (anterior) distribution includes the cervical plexus (C1-C4) and brachial plexus (C5-C8) [WP,unvetted].
Innervates: sternohyoid muscle, sternothyroid muscle, omohyoid muscle[WP]
The transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure.
A transparent and refractive lens located posterior to the iris. The lens of camera-type eye refracts light to be focused on the retina.
The lens is avascular and nourished by diffusion from the aqueous and vitreous humors.
The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
Currently this class encompasses only verteberate AOs but could in theory also include cephalopod - we may want to make a more specific class for vertebrate retina. note that this class excludes ommatidial retinas, as the retina must be part of an eyeball. Use the parent class photoreceptor array / light-sensitive tissue for arthropods
The smallest morphological and functional unit of the compound eye that consists of a usually limited and often constant number of rhabdomeric photoreceptor cells, cornea-secreting epithelial cells, and interommatidial pigment cells, and may additionally contain crystalline cone cells.
An organism subdivision that extends from the head to the pectoral girdle, encompassing the cervical vertebral column.
The invaginated serous membrane that surrounds the lungs (the visceral portion) and lines the walls of the pleural cavity (parietal portion).
Anatomical structure that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO].
The part of the central nervous system lying between the medulla oblongata and the midbrain, ventral to the cerebellum.
Anatomical system that has as its parts the organs concerned with reproduction.
Reproductive organ that produces and releases eggs (ovary) or sperm (testis).
The gonad of a female organism which contains germ cells.
female organism reproductive system gonad
female organism reproductive system gonada
gonad of female organism reproductive system
gonad of reproductive system of female organism
gonada of female organism reproductive system
gonada of reproductive system of female organism
reproductive system of female organism gonad
reproductive system of female organism gonada
The outer epithelial layer of the skin that is superficial to the dermis.
Functional system which consists of structures involved in respiration.
An airway through which respiratory air passes in organisms.
Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes.
Organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis[WP].
Portion of connective tissue composed of adipocytes enmeshed in areolar tissue.
A subdivision of the muscular system corresponding to a subdisivision of an organism.
The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO].
The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord.
A slender neuron projection bundle[FBbt]; A bundle of anatomical fibers, as of muscle or nerve (American Heritage Dictionary 4th ed).
EDITOR_NOTE note FBbt class not disjoint from tract. Consider merging with 'neuron projection bundle'
An enclosed, cable-like bundle of axons in the peripheral nervous system originating in a nerve root in the central nervous system (or a condensed nervous structure) connecting with peripheral structures.
A nerve that transmits from sensory receptors on the surface of the body to the central nervous system.
Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information.
The sensory system for the sense of taste.
A sac-like expansion of the ventral wall of the intestine, narrowed into a yolk stalk near the body[Hyman's]. Membranous sac attached to an embryo, providing early nourishment in the form of yolk in bony fishes, sharks, reptiles, birds, and primitive mammals. It functions as the developmental circulatory system of the human embryo, before internal circulation begins. In the mouse, the yolk sac is the first site of blood formation, generating primitive macrophages and erythrocytes[WP].
Anterior subdivision of a digestive tract.
A portion of the respiratory and digestive tracts; its distal limit is the superior part of the esophagus and it connects the nasal and oral cavities with the esophagus and larynx; it contains the valleculae and the pyriform recesses; its upper limits are the nasal cavity and cranial base.[FEED].
Consider generalizing to deuterostome pharynx
Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993).
Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue[FBbt, Hartenstein, V. (2004)].
In the developing vertebrate, the neural tube is the embryo's precursor to the central nervous system, which comprises the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or neural canal (which strictly speaking is the center of the neural tube), the ectodermal wall of which forms the rudiment of the nervous system. [WP,unvetted].
Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species.
A zone of skin that is part of a back [Automatically generated definition].
EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region
A terminal branch of the left or right common carotid artery which supplies oxygenated blood to to the throat, neck glands, tongue, face, mouth, ear, scalp and dura mater of the meninges[MP].
It ascends beneath the anterior margin of the trapezius, distributing branches to it, and to the neighboring muscles and lymph glands in the neck, and anastomosing with the superficial branch of the descending branch of the occipital artery.
superficial branch of transverse cervical artery
The transverse cervical artery splits into two branches, a superficial one and a deep one[WP]
A vein that carries deoxygenated blood from the lower half of the body into the right atrium of the heart.
A potential space between the visceral and parietal layers of the pericardium.
Endocardium that is part of the cardiac ventricle.
An epicardial layer that lines a cardiac ventricle.
Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer.
A zone of skin that is part of a head [Automatically generated definition].
A zone of skin that is part of a trunk [Automatically generated definition].
Transudate contained in the pleural cavity.
Joint fluid is a transudate of plasma that is actively secreted by synovial cells.
An anatomical wall that is part of a esophagus [Automatically generated definition].
A thin musculomebranous barrier that separates the abdominal and thoracic cavities. Often used for breathing control.
Muscle tissue composed of cardiac muscle cells, forming the muscles of the heart[ZFA,modified].
Muscle tissue that consists primarily of skeletal muscle fibers.
Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO].
Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. Wikipedia: The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri).
A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column..
A vein that carries deoxygenated blood from its corresponding ovary to inferior vena cava or one of its tributaries.
gonad of female reproductive system vein
gonada of female reproductive system vein
vein of female reproductive system gonad
vein of female reproductive system gonada
vein of gonad of female reproductive system
vein of gonada of female reproductive system
The layered structure that makes up the stomach, typiclly consists of a serous coat, a muscular coat, a mucous membrane, and other tissue layers in between.
The inner layer of peritoneum that is wrapped around organs located inside the intraperitoneal space.
Anatomical cavity bounded by visceral and parietal peritoneum.
The mucosal layer that lines the stomach.
The fibrous connective tissue layer beneath the stomach mucosa.
The outermost layer of the stomach wall, consisting of layers of connective tissue continuous with the peritoneum.
anatomical wall of stomach serous membrane
anatomical wall of ventriculus serous membrane
serosa of anatomical wall of ventriculus
serous membrane of anatomical wall of stomach
serous membrane of anatomical wall of ventriculus
serous membrane of stomach anatomical wall
serous membrane of ventriculus anatomical wall
ventriculus anatomical wall serous membrane
Transudate contained in the peritoneal cavity.
The outer layer of peritoneum that is attached to the abdominal and pelvic walls.
A zone of skin that is part of an abdomen [Automatically generated definition].
A zone of skin that is part of a neck [Automatically generated definition].
A zone of skin that is part of a thorax [Automatically generated definition].
An organism subdivision that includes the pectoral girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pectoral girdle regions.
Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system.
A subdivision of the head that has as parts the layers deep to the surface of the anterior surface, including the mouth, eyes, and nose (when present). In vertebrates, this includes the facial skeleton and structures superficial to the facial skeleton (cheeks, mouth, eyeballs, skin of face, etc).
A zone of skin that is part of a lip [Automatically generated definition].
Skeletal element that is composed of bone tissue.
An articular capsule (or joint capsule) is an envelope surrounding a synovial joint. [WP,unvetted].
The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta[GO]. A portion of the aorta commencing at the upper part of the base of the left ventricle, on a level with the lower border of the third costal cartilage behind the left half of the sternum; it passes obliquely upward, forward, and to the right, in the direction of the heart's axis, as high as the upper border of the second right costal cartilage, describing a slight curve in its course, and being situated, about 6 cm behind the posterior surface of the sternum. The total length is about 5 cm in length [Wikipedia].
The convex portion of the aorta between the ascending and descending parts of the aorta; branches from it include the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery; the brachiocephalic trunk further splits to form the right subclavian artery and the right common carotid artery.
The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries[GO]. The descending aorta is part of the aorta, the largest artery in the body. The descending aorta is the part of the aorta beginning at the aortic arch that runs down through the chest and abdomen. The descending aorta is divided into two portions, the thoracic and abdominal, in correspondence with the two great cavities of the trunk in which it is situated. Within the abdomen, the descending aorta branches into the two common iliac arteries which serve the legs. [WP,unvetted].
The part of the aorta that extends from the origin at the heart to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest.
Abdominal part of aorta: the distal part of the descending aorta, which is the continuation of the thoracic part and gives rise to the inferior phrenic, lumbar, median sacral, superior and inferior mesenteric, middle suprarenal, renal, and testicular or ovarian arteries, and celiac trunk[BTO]. The abdominal aorta is the largest artery in the abdominal cavity. As part of the aorta, it is a direct continuation of descending aorta(of the thorax). [WP,unvetted].
The short first aortic arch branch and divides into the right subclavian artery and the right common carotid artery.
A bilaterally paired branched artery that originates from the aortic arches and divides into and includes as parts the internal and external carotid arteries[cjm].
The rightmost of the two common carotid arteries, originating from in the neck from the brachiocephalic trunk.
right common carotid artery plus branches
A terminal branch of the left or right common carotid artery which supplies oxygenated blood to the brain and eyes[MP].
One of two laterally paired arteries that supplies the pectoral appendages, usually branching from the dorsal aorta.
The subclavian artery that supplies the right pectoral appendage.
The leftmost of the two common carotid arteries, originating from the aortic arch in the thorax.
left common carotid artery plus branches
A tube extending from the mouth to the anus.
The segment of the respiratory tract that starts proximally with the trachea and includes all distal structures including the lungs[WP,modified].
Either of a pair of lingual muscles with origin in the mandible, with insertion to the lingual fascia below the mucous membrane and epiglottis, with nerve supply from the hypoglossal nerve, and whose action depresses and protrudes the tongue.
A muscle that attaches to the hyopid bone and to the tongue and is innervated by cranial nerve XII.
A muscle organ that attaches the tongue to some other structure.
The intrinsic tongue muscles are an integral part of the tongue and completely contained within the tongue that are innervated by Cranial Nerve XII.
The subclavian artery that supplies the left pectoral appendage.
A vein that carries deoxygenated blood from the upper half of the body into the right atrium of the heart.
One of two jugular veins that collect the blood from the brain, the superficial parts of the face, and the neck. [WP,unvetted].
The bronchial veins are small vessels that return blood from the larger bronchi and structures at the roots of the lungs. The right side drains into the azygos vein, while the left side drains into the left superior intercostal vein or the accessory hemiazygos vein. The bronchial veins are counterparts to the bronchial arteries. The veins, however, do not return all of the blood supplied by the arteries; much of the blood that is carried in the bronchial arteries is returned to the heart via the pulmonary veins. [WP,unvetted].
The ciliary muscle is a ring of smooth muscle in the middle layer of the eye that controls the eye's accommodation for viewing objects at varying distances and regulates the flow of aqueous humour through Schlemm's canal. [WP,unvetted].
The lingual artery arises from the external carotid between the superior thyroid and facial artery[WP].
lingual branch of external carotid artery
A branch of the external carotid artery that supplies structures of the face. [WP,unvetted].
An artery that supplies deep structures of the face. It comes just out behind the neck of the mandible. [WP,unvetted].
One of a pair of right-sided and left-sided blood vessels in the circle of Willis. It connects the three cerebral arteries of the same side. Anteriorly, it is one portion of the terminal trifurcation of the internal carotid artery. The anterior cerebral artery and the middle cerebral artery are the other two branches of the trifurcation. Posteriorly, it communicates with the posterior cerebral artery.
posterior communicating segment of the basilar artery
Organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work[GO].
An epithelial tube or tree of tibes that transports blood away from the heart[modified from AEO definition].
Any of the tubular branching vessels that carry blood from the capillaries toward the heart.
Cranial nerve that has three branches - the ophthalmic (supplying the skin of the nose and upper jaw), the maxillary and the mandibular (supplying the lower jaw).
Cranial nerve that branches into the ramus communicans (to the skin), the pretrematic (to the walls of the pharynx and mouth, viscero-sensory fibers), and the larval post-trematic branch (lost in the adult).
Cranial nerve that innervates the muscles of the tongue.
The pulmonary artery that supplies the right lung.
The pulmonary artery that supplies the left lung.
The anterior facial vein (facial vein) commences at the side of the root of the nose, and is a direct continuation of the angular vein where it also receives a small nasal branch. It lies behind the facial artery and follows a less tortuous course. It receives blood from the external palatine vein before it either joins the anterior branch of the retromandibular vein to form the common facial vein, or drains directly into the internal jugular vein. [WP,unvetted].
The cerebral veins are divisible into external and internal groups according to the outer surfaces or the inner parts of the hemispheres they drain into. The external veins are the superior cerebral veins, inferior cerebral veins, and middle cerebral vein. [WP,unvetted].
The cranial ganglion that is associated with and extends fibers into the trigeminal nerve.
The bone at the lower, posterior part of the skull.
The large, irregular bone located at the base and side of the skull; consists of three parts at birth: squamous, tympanic, and petrous.
A horseshoe shaped bone situated in the anterior midline of the neck between the chin and the thyroid cartilage. The hyoid bone provides attachment to the muscles of the floor of the mouth and the tongue above, the larynx below, and the epiglottis and pharynx behind. [WP,modified].
The group of neuron cell bodies associated with the ninth cranial nerve.
Subdivision of skeletal system that surrounds and protects the brain. Includes the skull base, sensory capsules and the central part of the skull roof.
Subdivision of skeleton which includes upper and lower jaw skeletons.
Subdivision of head that consists of the lower jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm].
See notes for jaw w.r.t skeletal element vs subdivision of head
The groups of nerve cell bodies associated with the twelve cranial nerves.
cranial ganglion part of peripheral nervous system
A muscular organ in the floor of the mouth.
The cartilaginous joints of the skull; these include sphenoethmoidal synchondrosis, sphenooccipital synchondrosis, sphenopetrosal synchondrosis, petrooccipital synchondrosis, anterior intraoccipital synchondrosis and posterior intraoccipital synchondrosis.
A specialized receptor organ that is a collection of cells spanning the gustatory epithelium.
An anatomical space that is enclosed by a pharynx.
A continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration.
The cartilaginous structures that support the larynx.
Cranial nerve that branches into the lateral (to body sense organs) and the intestino-accessorial (to the skin, muscles of shoulder, hyoid, larynx, gut, lungs, and heart).
The space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens.
The pigmented middle of the three concentric layers that make up an eye, consisting of the iris, ciliary body and choroid[WP,edited].
The adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye.
The smooth stratified squamous epithelium that covers the outer surface of the cornea.
Opaque fibrous outer layer of the eyeball[ZFA,Kardong,WP].
Disease notes: implicated in rheumatoid arthritis.
A skeletal muscle organ that is part of the trunk region.
The thickened portion of the vascular tunic, which lies between the choroid and the iris, composed of ciliary muscle and ciliary processes.
Vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina. Along with the ciliary body and iris, the choroid forms the uveal tract[WP].
The lamellated connective tissue of the cornea between the Bowman and Descemet membranes.
A double layer covering the ciliary body that produces aqueous humor.
The delicate vascular connective tissue that lies between the anterior surface of the iris and the pars iridica retinae.
The any of the paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment[MP,modified].
Any of the layers that make up the retina[MP].
Cranial nerves are nerves that emerge directly from the brain, in contrast to spinal nerves, which emerge from segments of the spinal cord.
A thick watery refractive medium that fills the space between the lens and the cornea[WP].
The clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons, interneurons and non-neuronal supporting cells.
Any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive).
Any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive).
A layer of epithelial cells that is part of the eye.
The elastic, clear, membrane-like structure, that is outer most layer of the lens.
Ganglion that has dendrites that form a junction between autonomic nerves originating from the central nervous system and autonomic nerves innervating their target organs in the periphery. There are two subtypes, sympathetic ganglion and parasympathetic ganglion.
A ganglion of the sympathetic nervous system. Examples: paravertebral and the prevertebral ganglia, which include the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia.
ganglion of sympathetic part of autonomic division of nervous system
sympathetic part of autonomic division of nervous system ganglion
Ganglion containing neurons that receive innervation from parasympathetic neurons in the central nervous system and subserves parasympathetic functions through innervation of smooth muscle, cardiac muscle and glands.
The mucous lining of the larynx, which is composed of squamous epithelium in the upper larynx and ciliated columnar epithelium in the lower larynx.
One of the two fleshy folds which surround the opening of the mouth.
Lip that covers the lower portion of the mouth.[TAO].
One of two bilateral, largely symmetrical organ subdivisions within the telencephalon which contain the cerebral cortex and cerebral white matter.[FMA].
A nerve that arises from the caudal cervical nerves and is primarily the motor nerve of the diaphragm but also sends sensory fibers to the pericardium.
The most anterior region of the brain including both the telencephalon and diencephalon.
The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO].
A segment of the developing hindbrain[ZFA]. In the vertebrate embryo, a rhombomere is a transiently divided segment of the developing neural tube, within the hindbrain region (a neuromere) in the area that will eventually become the rhombencephalon. The rhombomeres appear as a series of slightly constricted swellings in the neural tube, caudal to the cephalic flexure.[WP].
Part of the forebrain consisting of paired olfactory bulbs and cerebral hemispheres.
The division of the forebrain that develops from the foremost primary cerebral vesicle.
Rostral segment of the hindbrain that has as its parts the pons (where present) and the cerebellum[WP,modified].
the terms metencephalon and myelencephalon are only meaningful in mammals and birds[Neuroanatomy of the Zebrafish Brain]. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata and thus these are not distinguished in ZFA[ZFA].
Organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures[FMA]. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate[GO].
The epithelial lining of the trachea which contains numerous ciliated cells.
An endothelium that is part of a capillary [Automatically generated definition].
An endothelium that is part of an arteriole [Automatically generated definition].
An endothelium that is part of an artery [Automatically generated definition].
An endothelium that is part of a venule [Automatically generated definition].
An endothelium that is part of a vein [Automatically generated definition].
Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP].
'tegmentum' is used generically for the ventral part of the brainstem (ISBN:0471888893). We use the label 'midbrain tegmentum' to denote the midbrain structure. In NIFSTD tegmentum is a composite structure and there is a separate class for midbrain tegmentum and pontine tegmentum
A multi-tissue structure that is part of a spinal cord.
An area of cerebral cortex defined on the basis of cytoarchitecture that have six layers. Starting from the cortical surface the layers are: molecular layer (I), external granular layer (II), external pyramidal layer (III), internal granular layer (IV), internal pyramidal layer (V), and multiform layer (VI). Neocortex is most prominent in the frontal lobe, the parietal lobe, the temporal lobe and the occipital lobe, less so in the cingulate gyrus, the parahippocampal gyrus and the insula. It is composed of two subdivisions: true isocortex and proisocortex (Carpenter-83)(NN).
The hyaline cartilaginous structures that support the bronchi, present as irregular rings in the larger bronchi (and not as regular as in the trachea), and as small plates and islands in the smaller bronchi; as the branching continues through the bronchial tree, the amount of hyaline cartilage in the walls decreases until it is absent in the smallest bronchioles[MP].
A submucosa that is part of a bronchus [Automatically generated definition].
The liquid component of blood, in which erythrocytes are suspended.
A submucosa that is part of a esophagus [Automatically generated definition].
A lamina propria that is part of a esophagus [Automatically generated definition].
A serous membrane that is part of a esophagus [Automatically generated definition].
The epithelial layer that lines the luminal space of the esophagus.
One of the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins.
The smallest division of the artery located between the muscular arteries and the capillaries[GO].
A vessel through which blood circulates in the body.
Any of the smallest blood vessels connecting arterioles with venules.
A monolayer of specialized, flattened, mitochondria-rich cells that lines the posterior surface of the cornea and faces the anterior chamber of the eye[WP].
A layer of epithelium that lines the heart, blood vessels (endothelium, vascular), lymph vessels (endothelium, lymphatic), and the serous cavities of the body[MESH]. Simple squamous epithelium which lines blood and lymphatic vessels and the heart[FMA].
The term 'endothelium' has been either restricted to the continuous cell layer of the vertebrates, as we are assuming here, or applied to all the cells able to adhere to the luminal surface of the vascular basement membrane (Casley-Smith 1980)
Cartilage tissue primarily composed of type II collagen (thin fibrils) and a glassy appearance.
An artery that carries deoxygenated blood from heart to the lungs. They are the only arteries (other than umbilical arteries in the fetus) that carry deoxygenated blood..
Pulmonary veins are blood vessels that transport blood from the lungs to the heart[GO].
A cranial nerve that originates from neurons in the medulla and in the cervical spinal cord.
A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons.
The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA].
An epithelium that is part of a bronchus [Automatically generated definition].
Muscle tissue that contains fibers that are divided by transverse bands into striations.
A systemic artery that supplies the lung with with oxygenated blood.
Although there is much variation, there are usually two bronchial arteries that run to the left lung, and one to the right lung.
The pontine raphe nucleus is one of the raphe nuclei. It is located in the pontine tegmentum. [WP,unvetted].
Respiration organ that develops as an outpocketing of the esophagus.
Snakes and limbless lizards typically possess only the right lung as a major respiratory organ; the left lung is greatly reduced, or even absent. Amphisbaenians, however, have the opposite arrangement, with a major left lung, and a reduced or absent right lung [WP]
An interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face.
Anatomical structure that is part of an embryo.
The truncus arteriosus and bulbus cordis are divided by the aorticopulmonary septum. The truncus arteriosus gives rise to the ascending aorta and the pulmonary trunk. The bulbus cordis gives rise to the smooth parts (outflow tract) of the left and right ventricles.
The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves[GO]. Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves[ZFA].
GO graph seems to suggest this is an endothelium. WP: The endocardial cushions are thought to arise from a subset of endothelial cells that undergo epithelial to mesenchymal transformation, a process whereby these cells break cell-to-cell contacts and migrate into the cardiac jelly (towards to interior of the heart tube). Latest (2010-06-01) new def suggested for GO, added above. Note that EHDAA2 has a more detailed model which we may later adopt. JB: Patterning makes the cushions lay down connective tissue in three domains that force out the local endothelial lining and so the leaflets form
The sinus venosus is a large cardiac chamber at the inflow tract that receives venous blood from systemic circulation. precedes the atrium on the venous side of the chordate heart.
The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP].
Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP].
An organ that is located within the body cavity (or in its extension, in the scrotum); it consists of organ parts that are embryologically derived from endoderm, splanchnic mesoderm or intermediate mesoderm; together with other organs, the viscus constitutes the respiratory, gastrointestinal, urinary, reproductive and immune systems, or is the central organ of the cardiovascular system. Examples: heart, lung, esophagus, kidney, ovary, spleen.
A cardiac atrium that is in the right side of the heart. It receives deoxygenated blood. In mammals, this comes from the superior and inferior vena cava and the coronary sinus, and pumps it into the right ventricle through the tricuspid valve.
A cardiac atrium that is in the left side of the heart. It receives oxygenated blood from the pulmonary veins, In mammals this is pumped into the left ventricle, via the Mitral valve.
A cardiac ventricle that is in the right side of the heart.
Cardiac chamber in which blood enters the heart.
Cardiac chamber through which blood leaves the heart.
A cardiac ventricle that is in the left side of the heart.
A cardiac septum that divides the left and right atria of the heart.
The postcranial subdivision of skeleton structural components forming the long axis of the vertebrate body; in Danio, consisting of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins; in human consists of the bones of the vertebral column, the thoracic cage and the pelvis[ZFA+FMA].
previous some AOs had used the term 'axial skeleton' to include the skull. This is being resolved (see tracker items above). Status: MA - fixed.
Subdivision of skeleton which which consists of all the skeletal elements in in the pectoral and pelvic appendage complexes[cjm].
The fibrous membrane forming the outer of the three coverings that surrounds the brain within the cranial cavity; consists of two layers including the periosteal layer and the meningeal layer.
A dura mater that is part of a spinal cord [Automatically generated definition].
Cardiac septum which separates the right ventricle from the left ventricle.[FMA].
The organ covering the body that consists of the dermis and epidermis.
The thin membranous structure between the two heart atria or the thick muscular structure between the two heart ventricles.
Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present.
The sensory system subserving the sense of vision.
Sensory system responsible for the perception of spatial orientation and auditory stimuli.
A portion of smooth muscle tissue that is part of an artery [Automatically generated definition].
A portion of smooth muscle tissue that is part of a esophagus [Automatically generated definition].
An ovary that is part of a right side of organism [Automatically generated definition].
An ovary that is part of a left side of organism [Automatically generated definition].
A collection of brainstem nuclei that functions in multiple aspects of hearing and is an important component of the ascending and descending auditory pathways of the auditory system.
superior olivary nucleus (Barr & Kiernan)
The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic[GO]. Bluish region in the superior angle of the fourth ventricle floor, corresponding to melanin-like pigmented nerve cells which lie lateral to the ponto-mesencephalic central gray (griseum centrale). It is also known as nucleus pigmentosus pontis[GAID].
Nucleus containing parasympathetic neurons giving rise to the parasympathetic division of the facial nerve, innervating the salivary glands (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 703).
The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers[GO].
fixed in GO to reflect FMA. See email to David/Varsha June 18 2010
Lung which consists of the right upper lobe, middle lobe and right lower lobe.[FMA].
Lung which consists of the left upper lobe and left lower lobe.[FMA].
The upper conducting airways of the lung; these airways arise from the terminus of the trachea.
A portion of adipose tissue that is part of the hypodermis, beneath the dermis.
Anatomical cluster consisting of the hematopoietic system and the lymphoid system, or its analogs.
Vasculature that is part of a head [Automatically generated definition].
A vasculature that is part of a trunk [Automatically generated definition].
Vasculature that is part of the eye region.
Anatomical system that consists of the muscular and skeletal systems.
Nonsynovial joint in which the articulating bones or cartilages are connected by ligaments. Examples: sagittal suture, inferior tibiofibular syndesmosis, gomphosis.[FMA].
Nonsynovial joint in which the articulating bones or cartilages are connected by cartilage. Examples: Spheno-occipital synchondrosis, first sternocostal joint, pubic symphysis.[FMA].
Cartilaginous joint in which the articulating bones or cartilages are connected by hyaline cartilage. Examples: spheno-occipital synchondrosis, first sternocostal joint.[FMA].
Cartilaginous joint in which the articulating bones or cartilages are connected by fibrocartilage. Examples: pubic symphysis, intervertebral symphysis, manubriosternal joint.[FMA].
Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA].
The part of the coelemic cavity lumen that is enclosed by the walls of the thorax.
Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO).
Endoskeletal elements that encase the brain, nose, inner ear[cjm]. that part of the neurocranium formed by endochondral ossification and comprising the bones of the base of the skull[TFD].
The ventral grey column of the spinal cord[MP]. The neurons of the ventral region of the mature spinal cord participate in motor output[GO].
A composite substructure of the brainstem that consists of the midbrain reticular formation, the pontine reticular formation and the medullary reticular formation ( Carpenter-1983 ).
Stalk-like part of the brain that includes amongst its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,MP,generalized].
'brainstem' is a loose term that sometimes refers to the ventral parts o the brain except for any part of the telencephalon - sometimes it includes the diencephalon or subpallial telencephalon structures (ISBN:0471888893). Here we use it in a more restriced sense, to include only the medulla oblongata, pons (when present) and the midbrain tegmentum (following the ZFA definitions).
One of the layers of the neocortex. These layers are defined by distinctive populations of cells based on somata size, shape, or density, that are aligned into sheets.
The atrial part of middle layer of the heart, comprised of involuntary muscle.
A neural nucleus that is part of the brain.
The ridge-shaped grey matter of the spinal cord that extends longitudunally through the center of each half of the spinal cord, and are largely or entirely composed of nerve cell bodies and their dendrites and some supportive tissue.
Neural tissue consisting of myelinated axons connecting grey matter areas of the central nervous system.
The regions of the spinal cord that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites.
The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities.
EDITOR_NOTE check the FMA placement here; ncit placement of body cavity here probably not correct
Any muscle organ that is part of a back [Automatically generated definition].
A flexible rod-shaped body found in embryos of all chordates. It is composed of cells derived from the mesoderm and defines the primitive axis of the embryo. In some chordates, it persists throughout life as the main axial support of the body, while in most vertebrates it becomes the nucleus pulposus of the intervertebral disc. The notochord is found ventral to the neural tube.
The notochord appears early in embryogeny and plays an important role in promoting or organizing the embryonic development of nearby structures. In most adult chordates the notochord disappears or becomes highly modified. In some non-vertebrate chordates and fishes the notochord persists as a laterally flexible but incompressible skeletal rod that prevents telescopic collapse of the body during swimming[TOLWEB]
Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm.
When the somite becomes segmented from the segmental plate, it is composed of an epithelial sac enclosing mesenchymal somitocoel cells. Thereafter the somite differentiates into two parts, the ventro-medial mesenchymal sclerotome and the dorso-lateral epithelial dermomyotome. This change in the epithelial somite depends on surrounding tissue [PMID:15906248]
Anatomical system that consists of the glands and parts of glands that produce exocrine secretions and help to integrate and control bodily metabolic activity. Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands). They are the counterparts to endocrine glands, which secrete their products (hormones) directly into the bloodstream (ductless glands) or release hormones (paracrines) that affect only target cells nearby the release site. [Wikipedia].
An arterial trunk which is continuous with the heart and branches into the pulmonary arteries.
A lamina propria that is part of a bronchus [Automatically generated definition].
lamina propria mucosa of bronchial trunk
lamina propria mucosae of bronchial trunk
A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP].
Gene notes: Many factors and genes, such as Pax3 (Tremblay et al., 1995), slug (Nieto et al., 1994), AP-2 (Zhang et al., 1996; Schorle et al., 1996), and Wnt-1/3a (Ikeya et al., 1997) are expressed in the dorsal most region of the neural tube, and have been shown to be involved in the generation of neural crest cells.
The part of the aorta that extends from the arch of the aorta to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest.
Embryonic ectoderm that gives rise to nervous tissue.
A region of the serous membrane that forms the innermost layer of the pericardium and the outer surface of the heart.
EDITOR_NOTE TODO - check links with UBERON:0002425 visceral serous pericardium. develops from proepicardium. WP:Epicardium -- When considered as a part of the pericardium, it is the inner layer, or visceral pericardium, continuous with the serous layer.
The middle layer of the heart, comprised mainly of striated cardiac muscle fibers.
EDITOR_NOTE TODO - check 'Myocardum proper' in FMA. We superclass the more generic class for now. FMA has is_a muscle layer - should we add this? ZFA and BTO both have is_a 'cardiac muscle' (tissue?). But in U we also follow FMA and have cardiac muscle tissue of myocardium (there is also Fibrocollagenous connective tissue of myocardium), which would be identical (see issue-10). Note that GO also treats left/right ventricular cardiac muscle tissue synonymous with ventricular myocardium
The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat[GO].
The part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node[GO]. Subdivision of conducting system of heart at the junction of the right atrium and the superior vena cava, around the sinoatrial nodal branch of right coronary artery and is continuous with the internodal tract[FMA].
WP:Heart states: "The SA node is found in all amniotes but not in more primitive vertebrates. In these animals, the muscles of the heart are relatively continuous and the sinus venosus coordinates the beat which passes in a wave through the remaining chambers. Indeed, since the sinus venosus is incorporated into the right atrium in amniotes, it is likely homologous with the SA node. In teleosts, with their vestigial sinus venosus, the main centre of coordination is, instead, in the atrium.". Note however that ZFA has SA node.
An area of conducting tissue between the atria and the ventricles of the heart that conducts the normal electrical impulse from the atria to the ventricles.
The cardiac Purkinje fiber is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle.
Serous membrane which is divided into parietal and visceral serous pericardium.
A serous membrane that lines the peritoneal cavity[VHOG,modified].
Membrane organ which is attached to the pericardial sac proper and the central tendon of diaphragm and is continuous with the pretracheal fascia.[FMA].
Membrane organ that surrounds the brain and the spinal cord.
Thick, fibrous meningeal covering surrounding the brain and spinal cord. It is the outermost of the three meningeal coverings. It consists of two layers: the periosteal dura linking the inner surface of the skull and the meningeal dura that lies above the arachnoid dural membrane. The meningeal layer draws away from the periosteal layer and certain locations to form the dural reflections.
A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas.
Endocrine glands are glands of the endocrine system that secrete their products directly into the circulatory system rather than through a duct.[WP, modified].
The soft tissue that fills the cavities of bones.
Any skeletal muscle that is part of the head region.
defined generically so could in theory encompass FBbt:00003260 'skeletal muscle of head', or the muscle of a starfish Aristotle's lantern, but we restrict this to craniates. Skeletal muscles of the head originate from the non-segmented head mesoderm (Noden, 1983; Wachtler et al., 1984)
Any muscle that is part of the cervical (neck) region.
Muscle (organ) which is a part of the abdomen. Examples: external oblique, rectus abdominis.
Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance.
Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO].
Vertebrate muscle is categorized into three major muscle types defined by their structural and functional properties: skeletal, cardiac and smooth. In Dmel the counterparts are somatic, heart/cardiac and visceral. Here we take a cell type based approach.
Anatomical system that is involved in the production of hematopoietic cells.
The outer serous membrane of the pulmonary pleural.
the part of the pleura external to the visceral pleura. It lines the inner surface of the chest wall, covers the diaphragm, and is reflected over the structures occupying the middle of the thorax
The inner serous membrane of the pulmonary pleural. The visceral pleura lines the lungs.
The fluid-filled cavity that lies between the visceral and parietal pleurae.
Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies.
A double-walled sac containing the heart and the roots of the great vessels.
The combination of pericardial sac (a double-walled sac containing the heart and the roots of the great vessels) plus fibrous pericardium.
Parietal serous membrane which is part of the pericardium and forms the outer layer of the pericardial sac.
Transudate contained in the pericardial cavity.[FMA].
The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands[GO].
autonomic division of peripheral nervous system
autonomic part of peripheral nervous system
divisio autonomica systematis nervosi peripherici
pars autonomica systematis nervosi peripherici
Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle.
Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts.
Previous: "A portion of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate[GO]. Regular connective tissue, which consists of chondrocytes and related cells, the intercellular matrix of which is chondrified. Examples: hyaline cartilage, fibrocartilage, elastic cartilage[FMA]. an avascular supporting and articular skeletal tissue. It also functions as the primary endoskeletal support in vertebrate embryos. Cartilage is deposited by and is composed of chondroblasts and chondrocytes separated by an extracellular matrix, which may or may not mineralize depending on cartilage type, age, or taxon[Hall and Witten]." See also FMA:71500 Set of cartilages, FMA:55107 Cartilage organ, FMA:12264 Articular cartilage. // elements made from cartilage, cartilage-like, or chondroid tissues evolved in invertebrates[H&W]
A gland that is part of a skin of body [Automatically generated definition].
An epithelium that is part of the mouth and lines the oral cavity, typically stratified squamous, and may be para-, ortho- or non- keratinized. Primary barrier between oral environment and deeper tissues.
Visceral serous membrane which is continuous with the parietal serous pericardium and is attached to the myocardium[FMA].
White matter that is part of a cerebral hemisphere.
white matter structure of cerebral hemisphere
A blood vessel that is part of a choroid [Automatically generated definition].
cannot find singular in FMA, using Set class
The small branching sprouts of the dorsal aorta that grow across the medial surface of the somite, turn right angles to grow over that surface and then fuse with other sprouts and form the vertebral arteries adjacent to the neural tube; the intersomitic arteries supply the body wall and persist in the adult as the posterior intercostal, subcostal and the lumbar arteries.
A mucosa that is part of a esophagus [Automatically generated definition].
Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts.
An epithelium that is part of a iris [Automatically generated definition].
Replacement bone that forms within cartilage.
Bone tissue forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP].
Connective tissue composed of elastic fibers.
The middle layer of an artery or vein. [WP,unvetted].
May be composed of smooth muscle and elastic tissue
The innermost layer of a blood vessel which is a lining of endothelial cells facing the lumen[Kardong].
An organ that functions as a secretory or excretory organ.
In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA].
Sense organ embedded in the integument and consisting of one or a cluster of sensory neurons and associated sensory structures, support cells and glial cells forming a single organised unit with a largely bona-fide boundary.[FBbt].
One of a series of paired bulges that develop along the lateral walls of the foregut. The pharyngeal arches have developmental contributions from endoderm, mesoderm, and neural crest cells and are separated by anterior lateral endoderm out-pockets known as pharyngeal pouches.
Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic.
Anatomical space which contains portions of one or more body substances and is bounded by the internal surface of one maximally connected anatomical structure. Examples: cranial cavity, pharyngeal recess space, nasal cavity, tooth socket, cavity of serous sac, lumen of stomach, lumen of artery, fornix of vagina.
The cavity that is enclosed by the central nervous system. In vertebrates this is the cavity that includes as parts ventricular cavities and the central canal of the spinal cord that develops from the lumen of the neura tube.
cavity of ventricular system of neuraxis
Anatomical divisons of the brain according to one or more criteria, e.g. cytoarchitectural, gross anatomy. Parts may be contiguous in 3D or not, e.g., basal ganglia.
A spinal cord segment that adjacent_to a cervical region.
A cerebral hemisphere that is in the left side of a brain.
A cerebral hemisphere that is in the right side of a brain.
Nucleus forming a longitudinal cell column in the medulla, close beneath the floor of the 4th ventricle, containing motor neurons that innervate the muscles of the tongue (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 453).
A nucleus of brain that is part of a trigeminal nuclear complex.
nucleus tractus mesencephali nervi trigeminalis
A sensory epithelium that is part of a gustatory system.
Dorsal portion of the pons, containing cranial nervee nuclei, ascending and descending tracts and reticular nuclei. It is continuous with the reticular formation of the medulla (Carpenter, A Core Text of Neuroanatomy, 3rd ed, 1985, pg 133).
A wall, dividing a cavity or structure into smaller ones[WP].
The thoracic nerves are the spinal nerves emerging from the thoracic vertebrae. [WP,unvetted].
A nerve fiber that is part of a trigeminal nerve.
The part of the brain that is the morphological boundary between the midbrain and hindbrain and that is the location of an organizing center which patterns the midbrain and hindbrain primordia of the neural plate.
The outermost layer (or layers, depending on the species) of embryonic skin, essential for the development of the epidermis and establishment of the barrier functions. The periderm derives from the outer layer of the ectoderm.
The portion of neural plate anterior to the mid-hindbrain junction.
The portion of neural plate posterior to the mid-hindbrain junction.
Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form.
Blood islands are structures in the developing embryo which lead to many different parts of the circulatory system. They primarily derive from plexuses formed from angioblasts. Within them, vacuoles appear through liquefaction of the central part of the syncytium into plasma. The lumen of the blood vessels thus formed is probably intracellular. The flattened cells at the periphery form the endothelium. The nucleated red blood corpuscles develop either from small masses of the original angioblast left attached to the inner wall of the lumen or directly from the flat endothelial cells. In either case the syncytial mass thus formed projects from and is attached to the wall of the vessel. Such a mass is known as a blood island and hemoglobin gradually accumulates within it. Later the cells on the surface round up, giving the mass a mulberry-like appearance. Then the red blood cells break loose and are carried away in the plasma. Such free blood cells continue to divide. Blood islands have been seen in the area vasculosa in the omphalomesenteric vein and arteries, and in the dorsal aorta[WP, unvetted].
A horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann's organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue.
The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads.
The second pharyngeal arch will form the hyoid apparatus. The cranial neural crest cells that populate the second pharyngeal arch emerge primarily from rhombomere 4 and will form skeletal elements.
Lateral neurogenic placodes positioned dorsal of the epibranchial placodes.
The only remaining dorsolateral placode in land vertebrates is the otic/octaval placode
The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord.
A neurogenic placode that arises at the level of the midbrain-hindbrain boundary and develops into a trigeminal ganglion.
Portion of tissue that is part of the anterior neural keel and will form the optic vesicle[ZFA]. A paired ectodermal placode that becomes invaginated to form the embryonic lens vesicles.
Multi-tissue structure that is comprised of neural and non-neural epithelial layers which will form the retina and retinal pigmented epithelium of the mature eye[ZFA]. double walled structured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye[MP].
A thickened portion of ectoderm which serves as the precursor to the lens. SOX2 and Pou2f1 are involved in its development[WP].
A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA].
The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO].
Focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches and that produce the neuroblasts that migrate and condense to form the distal cranial ganglia.
Portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures[MP].
A transitional population of migrating mesenchymal cells that derive from somites and that will become muscle cells.
Trunk portion of the neural crest. The trunk neural crest lies between the vagal and sacral neural crest and gives rise to two groups of cells. One group migrates dorsolateral and populates the skin, forming pigment cells and the other migrates ventrolateral through the anterior sclerotome to become the epinephrine-producing cells of the adrenal gland and the neurons of the sympathetic nervous system. Some cells remain in the sclerotome to form the dorsal root ganglia [Wikipedia].
Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone.
Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP].
Neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordia; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage.
Gonochoristic organism that can produce female gametes.
Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism.
Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types.
Portion of tissue composed of mesenchymal cells (motile cells that develop from epthelia via an epithelial to mesenchymal transition) and surrounding extracellular material. Mesenchyme has different embryological origins in different metazoan taxa - in many invertebrates it derives in whole or part from ectoderm. In vertebrates it derives largely from mesoderm, and sometimes the terms are used interchangeably, e.g. lateral plate mesoderm/mesenchyme.
Subdivision of skeleton that includes all dermal bones in the cranial skeleton[ZFA,modified].
The third branchial arch contributes to the development of the hyoid bone, stylopharyngeus muscle, inferior parathyroid gland, and thymus.
Contributes to development of the cartilage of the larynx, laryngeal, pharyngeal, and soft palate muscles, superior parathyroid gland, and C-cells of the thymus.
The 6th pharyngeal arch. contributes to the development of the sternocleidomastoid and trapezius muscles.
The vessels formed within the first pair of branchial arches in embryogenesis.
The vessels formed within the second pair of branchial arches in embryogenesis.
The vessels formed within the third pair of branchial arches in embryogenesis.
The vessels formed within the fourth pair of branchial arches in embryogenesis.
The vessels formed within the sixth pair of branchial arches in embryogenesis.
The trachea is the portion of the airway that attaches to the bronchi as it branches [GO:dph].
Upper portion of the skull that excludes the mandible (when present in the organism).
Anatomical structure that is part of the head consisting entirely of cranium and mandible[WP].
A female organ involved in reproduction.
female organism reproductive system organ
reproductive structure of female organism
reproductive system organ of female organism
Any sense organ that functions in (some) detection of chemical stimulus involved in sensory perception of taste (GO:0050912).
Septum that divides the ovary, the basal portion of a carpel or group of fused carpels, that encloses the ovule(s)[GO].
An epithelium that is part of a lower jaw [Automatically generated definition].
epithelial tissue of ventral mandibular arch
ventral mandibular arch epithelial tissue
The portion of the yolk sac that is derived from endoderm and lines the yolk sac.
An endoderm that is part of a foregut [Automatically generated definition].
A portion of skeletal muscle tissue that is part of a eye [Automatically generated definition].
A subdivision of the skeleton that corresponds to the lower part of the mouth. The lower jaw skeleton includes the following elements, when present: lower jaw teeth, the mandible and other lower jaw bones, and Meckel's cartilage.
An endothelium that is part of a trachea.
A meninx that is part of a midbrain [Automatically generated definition].
A meninx that is part of a telencephalon [Automatically generated definition].
A meninx that is part of a diencephalon [Automatically generated definition].
A meninx that is part of a hindbrain [Automatically generated definition].
A meninx that is part of a spinal cord [Automatically generated definition].
A gland that is part of a foregut [Automatically generated definition].
Racemose mucous glands beneath the mucous membrane of the pharynx.
Any gland that is part of the diencephalon. Examples: pineal gland, neurohypophysis.
A gland that is part of a integumental system [Automatically generated definition].
A blood island that is part of a mesoderm.
Mesenchyme that is part of a developing camera-type eye.
Mesenchyme that is part of a developing ovary [Automatically generated definition].
female reproductive system gonad mesenchyme
female reproductive system gonada mesenchyme
gonad of female reproductive system mesenchyme
gonada of female reproductive system mesenchyme
mesenchyme of female reproductive system gonad
mesenchyme of female reproductive system gonada
mesenchyme of gonad of female reproductive system
mesenchyme of gonada of female reproductive system
The portion of the yolk sac that is derived from mesoderm and consists of mesenchyme.
Mesenchyme that is part of a developing lower jaw [Automatically generated definition].
A spatially aggregated collection of nerve cell bodies in the PNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections. (CUMBO).
A ganglion that is part of a central nervous system [Automatically generated definition].
A mucosa that is part of a oral opening [Automatically generated definition].
A layer of epithelial cells on the surface of the mucosa.
An epithelium that is part of a pharynx [Automatically generated definition].
An epithelium that is part of a tongue [Automatically generated definition].
examples: tongue squamous epithelium, keratined, non-keratinized and parakeratinized epithelium, as well as gustatory epithelium. Note that not all these subtypes are named in individual anatomy ontologies.
An epithelium that is part of a right lung [Automatically generated definition].
An epithelium that is part of a left lung [Automatically generated definition].
An unilaminar epithelium that surrounds a pectoral appendage bud.
A portion of cardiac muscle tissue that is part of a right atrium [Automatically generated definition].
cardiac muscle tissue of heart right atrium
cardiac muscle tissue of right atrium of heart
textus muscularis of myocardium of right atrium
textus muscularis of myocardium of right atrium of heart
textus muscularis of myocardium of right cardiac atrium
A portion of cardiac muscle tissue that is part of a left atrium [Automatically generated definition].
cardiac left atrium cardiac muscle tissue
textus muscularis of myocardium of cardiac left atrium
textus muscularis of myocardium of heart left atrium
textus muscularis of myocardium of left atrium
textus muscularis of myocardium of left atrium of heart
textus muscularis of myocardium of left cardiac atrium
A portion of cardiac muscle tissue that is part of a right ventricle [Automatically generated definition].
cardiac muscle tissue of right ventricle
A portion of cardiac muscle tissue that is part of a left ventricle [Automatically generated definition].
A portion of cardiac muscle tissue that is part of an interventricular septum [Automatically generated definition].
cardiac muscle of interventricular septum
cardiac muscle tissue of interventricular septum
A portion of skeletal muscle tissue that is part of a pharynx [Automatically generated definition].
Any of the striated muscles that move the eye and include: superior rectus, inferior rectus, medial rectus, lateral rectus, superior oblique, inferior oblique, retractor bulbi.
A portion of smooth muscle tissue that is part of a trachea [Automatically generated definition].
A mesothelium that is part of a pericardium [Automatically generated definition].
cavity of pericardial sac meso-epithelium
meso-epithelium of cavity of pericardial sac
mesothelium of cavity of pericardial sac
A mesothelium that is part of a diaphragm [Automatically generated definition].
A mesothelium that is part of a pleural cavity [Automatically generated definition].
A cartilage element that is part of a respiratory system [Automatically generated definition].
A gland that is part of a digestive tract [Automatically generated definition].
Any of the mucous, serous, or mixed glands that empty their secretions onto the surface of the tongue.
Mesenchyme that is part of a pectoral appendage bud.
Mesenchyme that is part of a developing tongue [Automatically generated definition].
An adipose tissue that is part of a dermis [Automatically generated definition].
A nerve that is part of an abdomen [Automatically generated definition].
A nerve that is part of a neck [Automatically generated definition].
A nerve that is part of the trunk region of the body (not to be confused with a nerve trunk).
A nerve that is located in a thoracic cavity [Automatically generated definition].
A bone that is part of a head [Automatically generated definition].
Different sources vary regarding which bones are craniofacial; e.g. hyoid bone
A bone that is part of a neck [Automatically generated definition].
A bone that is part of a facial skeleton [Automatically generated definition].
A bone that is part of a trunk [Automatically generated definition].
An artery that is part of a respiratory system [Automatically generated definition].
The inferior labial artery (inferior labial branch of facial artery) arises near the angle of the mouth; it passes upward and forward beneath the Triangularis and, penetrating the Orbicularis oris, runs in a tortuous course along the edge of the lower lip between this muscle and the mucous membrane. It supplies the labial glands, the mucous membrane, and the muscles of the lower lip; and anastomoses with the artery of the opposite side, and with the mental branch of the inferior alveolar artery.
ramus labialis inferior (arteria facialis)
An artery that is part of a thoracic cavity[cjm].
One of the arteries supplying a meninix[Automatically generated definition].
A vein that is part of a respiratory system [Automatically generated definition].
The inferior labial vein is the vein receiving blood from the lower lip.
A vein that is part of a thoracic cavity [Automatically generated definition].
An endothelium of capillary that is part of a respiratory system [Automatically generated definition].
apparatus respiratorius blood capillary endothelium
apparatus respiratorius capillary endothelium
apparatus respiratorius capillary vessel endothelium
apparatus respiratorius endothelium of blood capillary
apparatus respiratorius endothelium of capillary
apparatus respiratorius endothelium of capillary vessel
blood capillary endothelium of apparatus respiratorius
blood capillary endothelium of respiratory system
capillary endothelium of apparatus respiratorius
capillary endothelium of respiratory system
capillary vessel endothelium of apparatus respiratorius
capillary vessel endothelium of respiratory system
endothelium of blood capillary of apparatus respiratorius
endothelium of blood capillary of respiratory system
endothelium of capillary of apparatus respiratorius
endothelium of capillary of respiratory system
endothelium of capillary vessel of apparatus respiratorius
endothelium of capillary vessel of respiratory system
respiratory system blood capillary endothelium
respiratory system capillary vessel endothelium
respiratory system endothelium of blood capillary
respiratory system endothelium of capillary
respiratory system endothelium of capillary vessel
respiratory system capillary endothelium
A venule that is part of a respiratory system [Automatically generated definition].
An arteriole that is part of a respiratory system [Automatically generated definition].
A blood vessel that is part of a head [Automatically generated definition].
A blood vessel that is part of an abdomen [Automatically generated definition].
A blood vessel that is part of a heart [Automatically generated definition].
A blood vessel that is part of a brain [Automatically generated definition].
A blood vessel that is part of a cornea [Automatically generated definition].
A blood vessel that is part of a retina [Automatically generated definition].
blood vessel of tunica interna of eyeball
A blood vessel that is part of a neck [Automatically generated definition].
A blood vessel that is part of a respiratory system [Automatically generated definition].
A blood vessel that is part of a trachea.
A blood vessel that is part of the arterial system. Includes artery, arteriole and aorta.
only in MA - supertype of artery, arteriole, aorta.
A blood vessel that is part of a iris [Automatically generated definition].
A blood vessel that is part of a lung [Automatically generated definition].
A blood vessel that is part of a trunk [Automatically generated definition].
A blood vessel that is part of a thoracic cavity [Automatically generated definition].
A capillary that is part of a respiratory system [Automatically generated definition].
apparatus respiratorius capillary vessel
blood capillary of apparatus respiratorius
capillary vessel of apparatus respiratorius
A gray matter that is part of a brain [Automatically generated definition].
The regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites.
A meninx that is part of a brain [Automatically generated definition].
A meninx that is part of a forebrain [Automatically generated definition].
A dura mater that is part of a forebrain.
A dura mater that is part of a midbrain [Automatically generated definition].
A dura mater that is part of a telencephalon [Automatically generated definition].
A dura mater that is part of a diencephalon [Automatically generated definition].
dura mater of neuraxis of mature diencephalon
mature diencephalon dura mater of neuraxis
A dura mater that is part of a hindbrain [Automatically generated definition].
A portion of connective tissue that is part of a head [Automatically generated definition].
portion of connective tissue of adult head
A portion of connective tissue that is part of an abdomen [Automatically generated definition].
A portion of connective tissue that is part of a neck [Automatically generated definition].
neck (volume) portion of connective tissue
portion of connective tissue of neck (volume)
A portion of connective tissue that is part of a respiratory system [Automatically generated definition].
apparatus respiratorius connective tissue
apparatus respiratorius portion of connective tissue
apparatus respiratorius textus connectivus
connective tissue of apparatus respiratorius
portion of connective tissue of apparatus respiratorius
portion of connective tissue of respiratory system
respiratory system portion of connective tissue
textus connectivus of apparatus respiratorius
textus connectivus of respiratory system
A portion of connective tissue that is part of a trachea.
A portion of connective tissue that is part of a lower respiratory tract [Automatically generated definition].
connective tissue of lower respiratory tract
lower respiratory tract portion of connective tissue
lower respiratory tract textus connectivus
portion of connective tissue of lower respiratory tract
textus connectivus of lower respiratory tract
lower respiratory tract connective tissue
A portion of connective tissue that is part of a larynx [Automatically generated definition].
A portion of connective tissue that is part of a dermis [Automatically generated definition].
A portion of connective tissue that is part of a trunk [Automatically generated definition].
A portion of connective tissue that is part of a bronchus [Automatically generated definition].
bronchial trunk portion of connective tissue
portion of connective tissue of bronchial trunk
portion of connective tissue of bronchus
A portion of connective tissue that is part of a thoracic cavity [Automatically generated definition].
cavity of chest portion of connective tissue
cavity of thorax portion of connective tissue
chest cavity portion of connective tissue
pectoral cavity portion of connective tissue
portion of connective tissue of cavity of chest
portion of connective tissue of cavity of thorax
portion of connective tissue of chest cavity
portion of connective tissue of pectoral cavity
portion of connective tissue of thoracic cavity
thoracic cavity portion of connective tissue
A cartilage that is part of a neck [Automatically generated definition].
A cartilage that is part of a lower respiratory tract [Automatically generated definition].
The ring-shaped cartilaginous structures that support the trachea.
A skin gland that is part of a camera-type eye [Automatically generated definition].
The dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall.
adult aorta textus connectivus elasticus
dorsal aorta textus connectivus elasticus
elastic connective tissue of adult aorta
elastic connective tissue of dorsal aorta
elastic connective tissue of trunk of aortic tree
textus connectivus elasticus of adult aorta
textus connectivus elasticus of dorsal aorta
textus connectivus elasticus of trunk of aortic tree
trunk of aortic tree elastic connective tissue
trunk of aortic tree textus connectivus elasticus
The type of heart connective tissue found in the endocardial layer that consists mainly of elastic fibers.
An elastic tissue that is part of a respiratory system [Automatically generated definition].
apparatus respiratorius elastic connective tissue
apparatus respiratorius textus connectivus elasticus
elastic connective tissue of apparatus respiratorius
elastic connective tissue of respiratory system
elastic tissue of apparatus respiratorius
respiratory system elastic connective tissue
respiratory system textus connectivus elasticus
textus connectivus elasticus of apparatus respiratorius
textus connectivus elasticus of respiratory system
An elastic tissue that is part of a circulatory system [Automatically generated definition].
cardiovascular system elastic connective tissue
cardiovascular system textus connectivus elasticus
circulatory system elastic connective tissue
circulatory system textus connectivus elasticus
elastic connective tissue of cardiovascular system
elastic connective tissue of circulatory system
textus connectivus elasticus of cardiovascular system
textus connectivus elasticus of circulatory system
Elastic tissue layer that lines a blood vessel layer.
blood vessel textus connectivus elasticus
elastic connective tissue of blood vessel
textus connectivus elasticus of blood vessel
Elastic tissue that is part of a lung [Automatically generated definition].
An elastic tissue that is part of a bronchus [Automatically generated definition].
bronchial trunk elastic connective tissue
bronchial trunk textus connectivus elasticus
elastic connective tissue of bronchial trunk
textus connectivus elasticus of bronchial trunk
textus connectivus elasticus of bronchus
An elastic tissue that is part of a trachea [Automatically generated definition].
cartilaginous trachea elastic connective tissue
cartilaginous trachea textus connectivus elasticus
elastic connective tissue of cartilaginous trachea
elastic connective tissue of vertebrate trachea
textus connectivus elasticus of cartilaginous trachea
textus connectivus elasticus of vertebrate trachea
textus connectivus elasticus of windpipe
vertebrate trachea elastic connective tissue
vertebrate trachea textus connectivus elasticus
The middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers.
The innermost layer of the aorta, containing the endothelium and an inner elastic membrane.
An arterial blood vessel that is part of a respiratory system [Automatically generated definition].
respiratory system arterial blood vessel
The part of the ventral body cavity that is within the abdomen proper (excluding the pelvic cavity).
Fibrous joint in which the articulating bones or cartilages of the skull are connected by sutural ligaments (scant amount of collagenous dense connective tissue). Examples: sagittal suture, frontal suture.
In anatomy, in the occipital bone, the foramen magnum is one of the several oval or circular apertures in the base of the skull, through which the medulla oblongata (an extension of the spinal cord) enters and exits the skull vault. Apart from the transmission of the medulla oblongata and its membranes, the foramen magnum transmits the Spinal Accessory nerve, vertebral arteries, the anterior and posterior spinal arteries, the membrana tectoria and alar ligaments. [WP,unvetted].
Design pattern notes: check whether this fits the foramen design pattern
The tissues that surround the organs that are present within the abdominal cavity. The abdominal wall tissue is composed of layers of fat, parietal peritoneum, fascia, and muscles.
A circle of arteries that supply blood to the brain. The Circle of Willis comprises the following arteries: Anterior cerebral artery (left and right); Anterior communicating artery; Internal carotid artery (left and right); Posterior cerebral artery (left and right); Posterior communicating artery (left and right).The basilar artery and middle cerebral arteries, supplying the brain, are also considered part of the circle.
The left and right brachiocephalic veins in the upper chest are formed by the union of each corresponding internal jugular vein and subclavian vein. This is at the level of the sternoclavicular joint. These great vessels merge to form the superior vena cava. The brachiocephalic veins are the major veins returning blood to the superior vena cava.
Portion of tissue in the nervous system which consists of neurons and glial cells, and may also contain parts of the vasculature.
The major nerves supplying sympathetic innervation to the abdomen, including the greater, lesser, and lowest (or smallest) splanchnic nerves that are formed by preganglionic fibers from the spinal cord which pass through the paravertebral ganglia and then to the celiac ganglia and plexuses and the lumbar splanchnic nerves carry fibers which pass through the lumbar paravertebral ganglia to the mesenteric and hypogastric ganglia.
A branch of the vagus nerve that supplies motor function and sensation to the larynx (voice box). It travels within the endoneurium. It is the nerve of the 6th Branchial Arch.
recurrent laryngeal nerve from vagus nerve
vagus X nerve recurrent laryngeal branch
The lingual nerve is a branch of the mandibular nerve (CN V3), itself a branch of the trigeminal nerve, which supplies sensory innervation to the tongue. It also carries fibers from the facial nerve, which return taste information from the anterior two thirds of the tongue.
The twelve spinal nerves on each side of the thorax. They include eleven INTERCOSTAL NERVES and one subcostal nerve. Both sensory and motor, they supply the muscles and skin of the thoracic and abdominal walls.
The intercostal nerves are the anterior divisions (rami anteriores; ventral divisions) of the thoracic spinal nerves from T1 to T11. Each nerve is connected with the adjoining ganglion of the sympathetic trunk by a gray and a white ramus communicans. The intercostal nerves are distributed chiefly to the thoracic pleura and abdominal peritoneum and differ from the anterior divisions of the other spinal nerves in that each pursues an independent course without plexus formation. The first two nerves supply fibers to the upper limb in addition to their thoracic branches; the next four are limited in their distribution to the parietes of the thorax; the lower five supply the parietes of the thorax and abdomen. The 7th intercostal nerve terminates at the xyphoid process, at the lower end of the sternum. The 10th intercostal nerve terminates at the umbilicus. The twelfth thoracic is distributed to the abdominal wall and groin. [WP,unvetted].
A nerve that is part of a thorax [Automatically generated definition].
A nerve that is part of an abdominal segment of trunk [Automatically generated definition].
A bone that is part of a thorax [Automatically generated definition].
A bone that is part of an abdominal segment of trunk [Automatically generated definition].
bone organ of abdominal segment of trunk
Any muscle organ that is part of a thorax [Automatically generated definition].
Any muscle organ that is part of a respiratory system [Automatically generated definition].
Any muscle organ that is part of a esophagus [Automatically generated definition].
A muscle organ that is part of an abdominal segment of trunk [Automatically generated definition].
muscle organ of abdominal segment of trunk
A blood vessel that is part of a thorax [Automatically generated definition].
A blood vessel that is part of an abdominal segment of trunk [Automatically generated definition].
blood vessel of abdominal segment of trunk
A skin of body that is part of an abdominal segment of trunk [Automatically generated definition].
A portion of connective tissue that is part of a thorax [Automatically generated definition].
A portion of connective tissue that is part of an abdominal segment of trunk [Automatically generated definition].
abdominal segment of trunk connective tissue
abdominal segment of trunk portion of connective tissue
abdominal segment of trunk textus connectivus
connective tissue of abdominal segment of trunk
portion of connective tissue of abdominal segment of trunk
textus connectivus of abdominal segment of trunk
An anatomical space that surrounded_by a neural tube.
In medicine, gonadal vein refers to the blood vessel that carrying blood away from the gonad (testis, ovary) toward the heart. Females : ovarian vein Males : testicular vein [WP,unvetted].
A neural crest that has_potential_to_developmentally_contribute_to a midbrain.
A neural crest that has_potential_to_developmentally_contribute_to a telencephalon.
A neural crest that has_potential_to_developmentally_contribute_to a diencephalon.
A neural crest that has_potential_to_developmentally_contribute_to a hindbrain.
A neural crest that has_potential_to_developmentally_contribute_to a spinal cord.
A neural plate that develops_from a future spinal cord.
Mesenchyme that is part of a developing gonad [Automatically generated definition].
A presumptive structure that has the potential to develop into a ganglion.
An anatomical cavity that has the potential to develop into a coelemic cavity lumen.
The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom.
Connective, non-functional supportive framework of a biological cell, tissue, or organ. Contrast with parenchyma.
One of the skeletal muscles of the head and neck, spine, and ribs.
A portion of skeletal muscle tissue in the trunk.
The part of the retina that contains neurons and photoreceptor cells[GO].
Small blood vessel similar to a capillary but with a fenestrated endothelium. Sinusoids are found in the liver, lymphoid tissue, endocrine organs, and hematopoietic organs such as the bone marrow and the spleen. Sinusoids found within terminal villi of the placenta are not comparable to these; they possess a continuous endothelium and complete basal lamina[WP].
endothelium of irregular blood filled space
Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.
Any endothelium that has the quality of being cylindrical [Automatically generated definition].
A blood vessel that carries blood from the capillaries toward the heart.
A duct that is part of a digestive system [Automatically generated definition].
An epithelium that lines the lumen of the digestive tract.
White matter that is part of a diencephalon [Automatically generated definition].
predominantly white regional part of diencephalon
A cartilage element of chondrocranium. Example: neurocranial trabecula.
A cartilage element that is part of the cranial skeleton.
Any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction.
The sensory system for the sense of touch and pain.
The anterior segment of the lamellated connective tissue layer of the cornea.
The posterior segment of the lamellated connective tissue layer of the cornea.
The slender connective tissue fiber in the extracellular matrix of skin tissue that is composed of microfibrils and amorphous elastin and is characterized by great elasticity.
The internal feminine genital organs, including the ovaries, uterine tubes, uterus, uterine cervix, and vagina.
internal genitalia of female reproductive system
TODO: Relabel. Make distinct organ class. See https://github.com/obophenotype/uberon/issues/547
The connection between the embryo proper and extraembryonic tissues.
A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells.
The single layer of epithelial cells that lines the early neural tube and develops into the nervous system and into the neural crest cells.
The transient outer neural tube region that contains the first generated post-mitotic neurons that receive synaptic input from thalamic axons and in turn project axons to the developing cortical plate.
The region of the developing mammalian cortex that extends between the ventricular zone and the cortical plate (CP); normally, the IZ is a region of tangential migration of cells, and at midgestation, the lower part of the IZ develops into the subventricular zone.
The layer of undifferentiated, proliferating cells that line the neural tube lumen that is the immediate transformation of the germinal neuroepithelium.
The layer of glia and differentiating neurons that forms as a second layer around the germinal neuroepithium; as this develops it comes to lie between the ventricular and marginal layers and includes the basal and alar plates. Develops into neurons and glia forming a gray matter layer.
The outermost layer of the neural tube that consists of axons from the developing mantle layer and will form the white matter.
The region of the mantle layer of the neural tube that lies ventral to the sulcus limitans and contains primarily motor neurons and interneurons.
Any of the veins that carries deoxygenated blood from a part of the body into the right atrium of the heart.
The subdivision of the face that includes the eye (eyeball plus adnexa such as eyelids) and the orbit of the skull and associated parts of the face such as the eyebrows, if present.
Any tube, opening or passage that connects two distinct anatomical spaces.
An internal pocketing of pharyngeal endoderm that contacts a region of ectoderm (a pharyngeal cleft) and interdigitates in the anterior and posterior directions with the pharyngeal arches.
The pouches are polarized structures. For example, whereas the rostral half of each pouch expresses Bmp-7, the caudal half expresses FGF-8 and the dorsal aspect of each pouch is marked via its expression of Pax-1. each pouch has an individual sense of identity. Shh expression is a prominent early feature of the caudal endoderm of the second arch, and individual pouches mark the anterior limits of expression of Hox genes within the pharyngeal endoderm; Hox-a2 has a rostral boundary at the second pouch, Hox-a3 at the third pouch and Hox-a4 at the most caudal pouch[PMID:16313389]
A vasculature that is part of a iris [Automatically generated definition].
An anatomical structure that develops (entirely or partially) from the endoderm.
An anatomical structure that develops (entirely or partially) from the mesoderm.
An anatomical structure that develops (entirely or partially) from the ectoderm.
The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup[GO]. Portion of tissue that is comprised of neuroepitheium which has pinched off from the anterior neural keel and will form the optic cup[ZFA].
Genes: Six3, Pax6, Rx1 are expressed together in the tip of the neural plate [ISBN:9780878932504 "Developmental Biology"]. Development notes: During subsequent develop- ment, the optic vesicle invaginates and becomes a two-layered structure with an inner neural retina and outer retinal pigment epithelium. As soon as the developing optic vesicle makes contact with the overlying ectoderm, it induces the ectoderm to thicken and form the lens placode [PMID:16496288]
Missing definition for term UBERON:0004133. Please replace it using linked reference.
The first recognizable structure derived from the heart field.
A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle.
An epithelial tube that will give rise to the mature heart.
The outflow tract septum is a partition in the outflow tract.
The outflow tract is the portion of the heart through which blood flows into the arteries.
The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles.
Vein of heart that drains the myocardium.
A cardiac chamber surrounds an enclosed cavity within the heart.
generic enough to cover FBbt:00003156 heart chamber but this is a cavity. GO defines it as the cavity. TODO - move subclasses. Note this also includes sinus venosus
An embryonic group of progenitor cells that forms from an outpouching of the septum transversum near the venous pole of the heart and gives rise to the epicardium.
A thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions. It gives rise to the central tendon of the diaphragm[VHOG].
The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals.
TODO: make a subdivision of reproductive system. Relabel. See https://github.com/obophenotype/uberon/issues/547
The external genitalia are the outer sex organs, such as the penis or vulva in mammals.
Organ that is part of the hematopoietic system.
The nonstriated, involuntary muscle tissue located in the wall of the aorta.
A portions of the gut that is derived from endoderm.
A nerve that is part of a back [Automatically generated definition].
A portion of smooth muscle tissue that is part of a stomach [Automatically generated definition].
A portion of smooth muscle tissue that is part of a respiratory system [Automatically generated definition].
A portion of smooth muscle tissue that is part of a digestive system [Automatically generated definition].
smooth muscle tissue of gastrointestinal system
A portion of smooth muscle tissue that is part of a lower respiratory tract [Automatically generated definition].
involuntary muscle of lower respiratory tract
lower respiratory tract involuntary muscle
lower respiratory tract non-striated muscle
lower respiratory tract smooth muscle tissue
non-striated muscle of lower respiratory tract
smooth muscle of lower respiratory tract
smooth muscle tissue of lower respiratory tract
A portion of smooth muscle tissue that is part of a iris [Automatically generated definition].
A portion of smooth muscle tissue that is part of an arteriole [Automatically generated definition].
Smooth muscle found within, and composing the majority of the wall of blood vessels.
A portion of smooth muscle tissue that is part of a bronchus [Automatically generated definition].
A portion of smooth muscle tissue that is part of a outflow tract [Automatically generated definition].
A bone that is part of the dorsal region of an animal.
Any muscle organ that is part of a skin of body [Automatically generated definition].
A blood vessel that is part of a back [Automatically generated definition].
A myocardium that is part of a outflow tract [Automatically generated definition].
A portion of connective tissue that is part of a back [Automatically generated definition].
A pericardium that is part of a outflow tract [Automatically generated definition].
A cranial suture that is part of a cartilaginous joint [Automatically generated definition].
articulatio cartilaginea cranial sutures
articulatio cartilaginea cranial sutures set
articulatio cartilaginea suture of cranium
cranial suture of articulatio cartilaginea
cranial sutures of articulatio cartilaginea
cranial sutures set of articulatio cartilaginea
cranial sutures set of cartilaginous joint
cranium suture of articulatio cartilaginea
suture of cranium of articulatio cartilaginea
suture of cranium of cartilaginous joint
A muscle that is part of the eye region.
Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body.
The bilaminar epithelium formed from the myotome and dermatome.
A cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube.
Dense connective tissue that separates the atria from the ventricles and provides physical support for the heart.
A nerve that is part of a parasympathetic nervous system [Automatically generated definition].
A blood vessel smooth muscle that is part of a respiratory system [Automatically generated definition].
smooth muscle tissue of blood vessel of respiratory system
respiratory system blood vessel smooth muscle
Outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo's means of nutrition.
The embryonic structure that gives rise to the corneal ectoderm.
Multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP].
An outgrowth on the lateral trunk of the embryo that develops into a limb or paired fin. The limb/fin bud is divided into ectoderm and mesenchyme[cjm, modified from MP].
Genes: In limb buds of chick and mouse, Shh expression is activated as soon as there is a morphological bud, whereas in S. canicula fin buds, consistent with reported data in other cartilaginous fishes, Shh is transcribed late in fin development[PMID:17187056]
The first of the series of pharyngeal arches that develop into jaw bones or their homologs, and their associated nerves and arteries.
One of a series of paired embryological vascular structures formed within a pharyngeal arch; in the adult, some of these vessels give rise to the great vessels[MP].
Thickened trophoblast of the blastocyst in rodents that becomes the fetal portion of the placenta.
Blood vessel that is connected to the yolk sac.
A transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea[MP].
The strong, resistant, thin, noncellular fourth layer of the cornea, located between the endothelium (from which it is secreted) and the stroma. (Cline et al., Dictionary of Visual Science, 4th ed)
A transparent homogeneous acellular layer, 6 to 9 um thick, lying between the basal lamina of the outer layer of stratified epithelium and the substantia propria of the cornea; it is considered to be a basement membrane.
Vascular network that is connected to the yolk sac.
A bone that is part of an appendage [Automatically generated definition].
bone of free segment of appendicular skeleton
One of three main pairs of arteries and their branches, which irrigate the cerebrum of the brain.
Sum of all sensory systems in an organism.
Any collection of skeletal muscles that is part of a head [Automatically generated definition].
This class is restricted to skeletal muscles that attach to the cranial skeleton. This seems to be consistent with FMA and EMAPA usage. Note that by definition this excludes invertebrate head musculature. It corresponds to the individual muscle organ term UBERON:0002376
Any collection of muscles that is part of a thorax [Automatically generated definition].
Any collection of muscles that is part of a neck [Automatically generated definition].
Any collection of muscles that is part of a back [Automatically generated definition].
A subdivision of the musculature of the body in the pectoral girdle region. Includes pectoral and shoulder muscles.
Any collection of muscles that is part of a face.
The collection of muscles that are part of the larynx.
Any collection of muscles that is part of a trunk [Automatically generated definition].
A portion of cardiac muscle tissue that is part of an atrium [Automatically generated definition].
A portion of cardiac muscle tissue that is part of a interatrial septum [Automatically generated definition].
interatrial septum cardiac muscle tissue
cardiac muscle tissue of interatrial septum
A portion of cardiac muscle tissue that is part of a cardiac septum [Automatically generated definition].
A portion of cardiac muscle tissue that is part of a myocardium [Automatically generated definition].
A portion of skeletal muscle tissue that is part of a diaphragm [Automatically generated definition].
A vasculature that is part of a muscle organ [Automatically generated definition].
A vasculature that is part of a musculoskeletal system [Automatically generated definition].
Anatomical system that has as its parts the heart and blood vessels.
A vascular network consisting of blood vessels.
An eye that is part of a left side of organism [Automatically generated definition].
An eye that is part of a right side of organism [Automatically generated definition].
The part of the arterial system which carries oxygenated blood away from the heart to the body, and returns deoxygenated blood back to the heart.
The part of the cardiovascular system consisting of all arteries.
An artery of the systemic circulation, which is the part of the cardiovascular system which carries oxygenated blood away from the heart, to the body, and returns deoxygenated blood back to the heart.
The part of the venous system that drains the general body tissues[Kardong].
The part of the cardiovascular system consisting of all venous vessels. In vertebrates with a double circulation, this can be divided into systemic and pulmonary portions.
An endothelium that lines the blood vasculature. Other endothelia may line lymph vessels, the heart.
An anatomical wall that is part of an aorta, enclosing the luminal space.
The outermost layer of the aorta wall, containing connective tissue and collagen and elastic fibers.
The membranous portion of the wall between the two lower chambers of the heart.
membranous part of interventricular septum
membranous portion of interventricular septum
pars membranacea (septi interventricularis)
The muscular portion of the wall between the two lower chambers of the heart.
muscular part of interventricular septum
pars muscularis (septi interventricularis)
The raphe nuclei are thin plates of cells in and immediately adjacent to the sagittal plane.
we treat NR obscurus, NR magnus etc as parts of the raphe nuclei. This is consistent with treatment in FMA, where the class is 'set of raphe nuclei'
The costocervical trunk arises from the upper and back part of the subclavian artery, behind the scalenus anterior on the right side, and medial to that muscle on the left side. Passing backward, it splits into the deep cervical artery and the supreme intercostal artery (or the Highest intercostal artery), which descends behind the pleura in front of the necks of the first and second ribs, and anastomoses with the first aortic intercostal (3rd posterior intercostal artery). As it crosses the neck of the first rib it lies medial to the anterior division of the first thoracic nerve, and lateral to the first thoracic ganglion of the sympathetic trunk. In the first intercostal space, it gives off a branch which is distributed in a manner similar to the distribution of the aortic intercostals. The branch for the second intercostal space usually joins with one from the highest aortic intercostal artery. This branch is not constant, but is more commonly found on the right side; when absent, its place is supplied by an intercostal branch from the aorta. Each intercostal gives off a posterior branch which goes to the posterior vertebral muscles, and sends a small spinal branch through the corresponding intervertebral foramen to the medulla spinalis and its membranes. [WP,unvetted].
A portion of smooth muscle tissue that is part of an arterial system [Automatically generated definition].
A portion of smooth muscle tissue that is part of a venous system [Automatically generated definition].
An endothelium that is part of a vena cava [Automatically generated definition].
An endothelium that is part of a outflow tract [Automatically generated definition].
An endothelium that is part of an arterial system [Automatically generated definition].
An endothelium that is part of a venous system [Automatically generated definition].
A blood vessel endothelium that is part of a respiratory system [Automatically generated definition].
respiratory system blood vessel endothelium
A transient fetal dilation of the distal (or cranial) heart tube located where the arterial trunk joins the ventral roots of the aortic arches.
An appendage that is part of an appendage girdle complex.
Paired appendage that consists of the anterior appendicular skeleton and associated soft and hard tissues, but excludes the pectoral girdle and its associated soft and hard tissues.
The jugular veins are veins that bring deoxygenated blood from the head back to the heart via the superior vena cava.
The embryo and its adnexa (appendages or adjunct parts) or associated membranes (i.e. the products of conception) The conceptus includes all structures that develop from the zygote, both embryonic and extraembryonic. It includes the embryo as well as the embryonic part of the placenta and its associated membranes - amnion, chorion (gestational sac), and yolk sac[WP].
A transverse unitary subdivision of the neural tube that shares a common dorsoventral structure (floor, basal, alar, and roof plates), but each having differential molecular identities and fates; they comprise the secondary prosencephalon, diencephalon (prosomeres), the midbrain (mesomeres), and the hindbrain (rhombomeres).
Any segmental subdivision of a nervous system. Includes metameric developmental segments, such as vertebrates neuromeres.
An organ subunit that is part of a hindbrain [Automatically generated definition].
The dentary is a dermal bone that forms the antero-lateral part of the lower jaw in fishes and amphibians, extending to the whole lower jaw in mammals[VHOG,modified].
A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO].
Four classes of mineralized tissues are found in vertebrates: bone, cartilage, dentine, and enamel. We think of cartilage and bone as skeletal tissues and of enamel and dentine as dental tissues, but enamel and dentine arose evolutionarily together with bone as skeletal tissues in the dermal skeleton (exoskeleton) of early vertebrates. Scales and teeth of sharks are examples of dermal skeletal elements that are still composed of the three ancient components-enamel, dentine, and bone. Cartilage, on the other hand, provided the basis for the second vertebrate skeletal system, the endoskeleton (Smith and Hall, 1990; Hall, 1998a,b). some invertebrate skeletal tissues have surprisingly bone-like features. Examples include chondrocytes interconnected by cell processes in cephalopod cartilages (Cole and Hall, 2004a,b), and the calcium phosphate layer in the shells of brachiopods (Rodland et al., 2003). However, neither bone nor mineralized cartilage have been found in invertebrates. Editors notes: TODO - develops_from
Dermis-derived entity that is made of skeletal tissue.
The primitive cartilagionous skeletal structure of the fetal skull that grows to envelop the rapidly growing embyonic brain. In humans, the chondrocranium begins forming at 28 days from mesenchymal condensations and is fully formed between week 7 and 9 of fetal development. While the majority of the chondrocranium is succeeded by the bony skull in most higher vertebrates, some components do persist into adulthood.[1] In Cartilagious fishes and Agnathans, the chondrocranium persist throughout life.[2] Embryologically, the chondrocranium represent the basal cranial structure, and lay the base for the formation of the endocranium in higher vertebrates[WP].
cartiligionous skeletal structure of skull
Bone tissue that forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP].
Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles.
Any bone that is part of the lower jaw skeleton. This includes (when present): the dentary/mandible, the articular, the splenial, the suprangular.
Anatomical system that consists of all the joints of the body.
A submucosa that is part of a respiratory system [Automatically generated definition].
A submucosa that is part of a larynx [Automatically generated definition].
A lamina propria that is part of a respiratory system [Automatically generated definition].
apparatus respiratorius lamina propria mucosa
lamina propria mucosa of apparatus respiratorius
lamina propria mucosa of respiratory system
lamina propria of apparatus respiratorius
respiratory system lamina propria mucosa
A lamina propria that is part of a gastrointestinal system.
A serous membrane that is part of a digestive system [Automatically generated definition].
serous membrane of gastrointestinal system
An anatomical wall that is part of a cardiac ventricle [Automatically generated definition].
anatomical wall of lower chamber of heart
The mucous membrane lining the respiratory tract.
mucosa of organ of apparatus respiratorius
mucous membrane of apparatus respiratorius
A mucosa that is part of a gastrointestinal system.
The gut mucosa of amphioxus has insulin-secreting cells. http://www.ncbi.nlm.nih.gov/pubmed/16417468
A secretion that is part of a esophagus [Automatically generated definition].
Any of the tissue layers that comprise a blood vessel. Examples: tunica media, tunica adventitia.
A basal lamina that is part of a respiratory system [Automatically generated definition].
apparatus respiratorius basal lamina of connective tissue
basal lamina of connective tissue of apparatus respiratorius
basal lamina of connective tissue of respiratory system
respiratory system basal lamina of connective tissue
A basal lamina that is part of a respiratory airway [Automatically generated definition].
basal lamina of connective tissue of respiratory airway
A basal lamina that is part of a bronchus [Automatically generated definition].
basal lamina of connective tissue of bronchi
basal lamina of connective tissue of bronchial trunk
basal lamina of connective tissue of bronchus
bronchi basal lamina of connective tissue
bronchial trunk basal lamina of connective tissue
bronchus basal lamina of connective tissue
The pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi.
An epithelium that is part of a respiratory system [Automatically generated definition].
apparatus respiratorius epithelial tissue
epithelial tissue of apparatus respiratorius
An epithelium that is part of a digestive system [Automatically generated definition].
epithelial tissue of gastrointestinal system
gastrointestinal system epithelial tissue
An epithelium that is part of a lower respiratory tract [Automatically generated definition].
epithelial tissue of lower respiratory tract
lower respiratory tract epithelial tissue
An epithelium that is part of a larynx [Automatically generated definition].
A portion of skeletal muscle tissue that is part of a respiratory system [Automatically generated definition].
respiratory system skeletal muscle tissue
skeletal muscle of apparatus respiratorius
skeletal muscle tissue of apparatus respiratorius
skeletal muscle tissue of respiratory system
A portion of skeletal muscle tissue that is part of a esophagus [Automatically generated definition].
Most muscle tissue lining the digestive tract is smooth, but part of the externa of the esophagus is skeletal
A portion of skeletal muscle tissue that is part of a lip [Automatically generated definition].
An endothelium of artery that is part of a respiratory system [Automatically generated definition].
apparatus respiratorius arterial endothelium
apparatus respiratorius artery endothelium
apparatus respiratorius endothelium of artery
arterial endothelium of apparatus respiratorius
arterial endothelium of respiratory system
artery endothelium of apparatus respiratorius
artery endothelium of respiratory system
endothelium of artery of apparatus respiratorius
endothelium of artery of respiratory system
respiratory system endothelium of artery
An endothelium of vein that is part of a respiratory system [Automatically generated definition].
apparatus respiratorius endothelium of vein
apparatus respiratorius vein endothelium
apparatus respiratorius venous endothelium
endothelium of vein of apparatus respiratorius
endothelium of vein of respiratory system
vein endothelium of apparatus respiratorius
venous endothelium of apparatus respiratorius
venous endothelium of respiratory system
The thin layer of flat cells that line the aorta and form a barrier between circulating blood in the lumen and the rest of the vessel wall.
endothelium of trunk of systemic arterial tree
trunk of systemic arterial tree endothelium
An endothelium that is part of the cardiovascular system.
A connective tissue that surrounds a skeletal muscle tissue.
connective tissue of skeletal muscle tissue
portion of connective tissue of skeletal muscle
portion of connective tissue of skeletal muscle tissue
skeletal muscle portion of connective tissue
skeletal muscle tissue connective tissue
skeletal muscle tissue portion of connective tissue
skeletal muscle tissue textus connectivus
textus connectivus of skeletal muscle tissue
A gland that is part of a eye. The eye is a compound unit which depending on the species may consist of an eyeballs plus associated ducts and integumentary structures. Eye glands therefore include the various types of lacrimal gland, the various types of apocrine and sebaceous glands associated with the eyelid.
Examples: harderian gland, accessory lacrimal gland, gland of Moll, gland of Zeis, nictitating membrane glands
A vasculature that is part of a retina [Automatically generated definition].
Layer of lateral plate mesoderm that forms the circulatory system and future gut wall - overlies endoderm[WP].
splanchnic layer of lateral plate mesoderm
A structure created during embryogenesis when the lateral mesoderm splits into two layers - the inner (or splanchnic) layer adheres to the endoderm, and with it forms the splanchnopleure[WP].
A structure created during embryogenesis when the lateral mesoderm splits into two layers - the outer (or somatic) layer becomes applied to the inner surface of the ectoderm, and with it forms the somatopleure.[WP].
The central region of trunk mesoderm. This tissue forms the notochord.
The mass of tissue made up of mesenchymal cells in the lung.
A neuron projection bundle that connects the retina or its analog in the eye with the brain. This includes the vertebrate optic nerve (not truly a nerve) as well as analogous structures such as the Bolwig nerve in Drosophila.
for the vertebrate-specific structure, see UBERON:0000941 (cranial nerve II)
neuron projection bundle connecting eye with brain
Anatomical structure that connects two or more adjacent skeletal elements or hardened body parts.
A portion of the gut that is derived from ectoderm.
The region of the digestive tract extending from the mouth cavity through pharynx esophagus stomach and duodenum.
A proximal-distal subdivision of the digestive tract.
A part of a wall of an organ that forms a layer.
The tissue underlying the tunica mucosa of the pharynx.
A mucosa that is part of a tongue [Automatically generated definition].
A mucosa that is part of a lower lip [Automatically generated definition].
An external genitalia that is part of a female reproductive system [Automatically generated definition].
external genitalia of female reproductive system
An organ that is part of a immune system [Automatically generated definition].
A gland that is part of a hemolymphoid system [Automatically generated definition].
The median dorsal longitudinal groove formed in the embryo by the neural plate after the appearance of the neural folds.
One of the two elevated edges of the neural groove[GO,MP].
A solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts[GO]. An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube[ZFIN].
An anatomical boundary that adjacent_to a forebrain and adjacent_to a midbrain.
An anatomical boundary that adjacent_to a hindbrain and adjacent_to a spinal cord.
An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm[GO].
Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms[GO].
A bud is a protrusion that forms from an epithelial sheet by localized folding.
Any anatomical structure that is part of the reproductive system.
An epithelial sheet bent on a linear axis.
The functional tissue of the central nervous system consisting of neurons and glial cells.
A remnant structure from earlier development or evolution.
A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part.
An organ or element that is in the abdomen. Examples: spleen, intestine, kidney, abdominal mammary gland.
An organ or element that is part of the adbominal segment of the organism. This region can be further subdivided into the abdominal cavity and the pelvic region.
An organ or element that part of the dorsum of the organism. Examples: spinal cord, vertebrae, muscles of back.
An organ or element that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions.
An organ or element that is in the thoracic cavity. Examples: lung, heart, longus colli.
An organ that part of the thoracic segment region. This region can be further subdividied chest and thoracic cavity regions.
A vein that is part of a thorax [Automatically generated definition].
A gland that is part of a larynx submucosa [Automatically generated definition].
An ectoderm that is part of a optic eminence [Automatically generated definition].
An endocardium that is part of a interventricular septum [Automatically generated definition].
interventricular septum endocardial tissue
A myocardium that is part of a bulbus cordis [Automatically generated definition].
An anatomical cavity that is part of a yolk sac [Automatically generated definition].
Portion of primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells.
Mesenchyme that is part of a developing trunk.
The posterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the medulla oblongata and a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII).[BTO,WP].
A portion of tissue that is part of an embryo.
Portion of tissue that is contiguous with the embryo and is comprised of portions of tissue or cells that will not contribute to the embryo.
The endothelial lining of the endocardium.
An pulmonary artery endothelium is an epithelium that lines the pulmonary artery[GO].
A lamina propria that is part of a mucosa of oral region.
A ventricular outflow tract is a portion of either the left ventricle or right ventricle of the heart through which blood passes in order to enter the great arteries. The right ventricular outflow tract (RVOT) is an infundibular extension of the ventricular cavity which connects to the pulmonary artery. The left ventricular outflow tract (LVOT), which connects to the aorta, is nearly indistinguishable from the rest of the ventricle[WP].
An outflow tract that is part of a aorta.
The outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers[MP].
The group of sensory neuron cell bodies associated with the vagus nerve.
An array of photoreceptors and any supporting cells found in an eye.
A transparent structure that is part of a visual sense organ, the function of which is to direct or focus light onto a photoreceptor array.
One of: the common carotid artery, or its branches, the external and internal carotid arteries.
A sex gland that is part of a female reproductive system.
A gray matter that is part of a cerebral hemisphere.
The part of the digestive system that excludes the hepatobiliary system.
alimentary part of gastrointestinal system
A limb bud that develops into a forelimb or pectoral fin.
at this time we have no need to name a more specific 'pectoral fin bud' class, but we may in future
An apical ectodermal ridge that is part of a pectoral appendage bud.
apical ectodermal ridge pectoral fin bud
pectoral appendage apical ectodermal ridge
Portion of tissue that is the inner layer of the optic cup and will become the neural retina.
Portion of tissue that gives rise to the lens.
Portion of tissue that is part of the eye and gives rise to the mature, fully layered cornea.
Vagal neural crest is adjacent to the first seven somites gives rise to both ganglionic and ectomesenchymal derivatives[ZFA].
The dilated structure that is lined by endothelial cells and located at the arterial pole of the heart just above (distal to) the truncus arteriosus in mammalian embryos; it is the primordial vascular channel from which the aortic arches (and eventually the dorsal aortae) arise; the aortic sac is homologous to the ventral aorta of gill-bearing vertebrates.
The jugular foramen is a large aperture in the base of the skull. It is located behind the carotid canal and is formed in front by the petrous portion of the temporal, and behind by the occipital; it is generally larger on the right than on the left side.
A vitelline vein that is in the left side of a multicellular organism.
A vitelline vein that is in the right side of a multicellular organism.
A longitudinal groove in the neural tube wall that divides the neural tube into dorsal (alar) and ventral (basal) halves (dorsal receives input from sensory neurons, ventral effects motor functions); stretches from the mesencephalon caudad[TMD].
neural tube lateral wall sulcus limitans
The paired veins that carry blood from the yolk sac back to the embryo.
Cranial neural crest which gives rise to the glossopharyngeal ganglion.
Portion of tissue on the side of the lumen of the neural tube.
Gene notes: One of the first genes to be expressed in nonneural ectoderm in amphioxus is BMP2/4 (Panopoulou et al. 1998). BMP2/4 homologues appear to have a very ancient role in distinguishing neural from nonneural ectoderm; in Drosophila as well as in amphioxus and vertebrates, BMP2/4 homologues are expressed in nonneural ectoderm and function in distinguishing neural from nonneural ectoderm (Francois & Bier, 1995 ; Sasai et al. 1995 ; Wilson & Hemmati-Brivanlou, 1995; Panopoulou et al. 1998). A change in level of BMP2/4 from very high in nonneural ectoderm to low in neural ectoderm appears to be a key factor in development of neural crest (Baker & Bronner-Fraser,1997a,1997b;Erickson&Reedy,1998;Marchantet al.1998 ;Selleck et al. 1998).
Multi-tissue structure that arises from the heart rudiment and will become the heart tube.
A neural tube lateral wall that is part of a rhombomere.
Cranial neural crest which gives rise to the trigeminal ganglion.
Portion of tissue that gives rise to the immature gonad.
Somite located in the head region, caudal to the otic vesicle.
A pair of lateral diverticula just over the liver rudiment representing the primordia of the lungs, formed by the floor of the foregut just anterior to the liver diverticulum.
A layer of cuboidal epithelial cells bounded anteriorly by the capsule of the lens and posteriorly by the lens cortex.
Intrinsic membrane that arises from embryonic germ layers and grow to surround the developing embryo.
An epithelium that is part of a anterior chamber of eyeball.
An epithelium that is part of a lens vesicle.
An ectoderm that is part of a pharyngeal arch 2.
An ectoderm that is part of a pharyngeal arch 3.
An ectoderm that is part of a pharyngeal arch 4.
An endoderm that is part of a pharyngeal arch 2.
An endoderm that is part of a pharyngeal arch 3.
An endoderm that is part of a pharyngeal arch 4.
A mesothelium that is part of a peritoneal cavity.
An endothelium that is part of a right lung.
An endothelium that is part of a left lung.
An anatomical cavity that is part of a lens vesicle.
Mesenchyme that is part of a pharyngeal arch 2.
Mesenchyme that is part of a pharyngeal arch 3.
Mesenchyme that is part of a pharyngeal arch 4.
Mesenchyme that is part of a optic eminence.
A venous system that is part of a hindbrain.
A limb/fin field that has the potential to develop into a pectoral appendage bud mesenchyme.
pectoral appendage field of lateral plate mesoderm
A ring of cells capable of forming a limb or paired fin[Gilbert,modified].
limb/fin field of lateral plate mesoderm
The outermost layer of a blood vessel, composed mainly of fibrous tissue.
A tunica intima that is part of a artery.
An outermost connective tissue covering of an organ, vessel, or other structure[WP].
Anatomical space that is an opening in a bone, usually for passage of blood vessels or nerves.
An acellular anatomical structure that is the bounding layer of a anatomical structure.
An acellular membrane that is part of the epithelium, lies adjacent to the epithelial cells, and is the fusion of the the basal lamina and the reticular lamina.
Any portion of the aorta including the ascending and descending aorta, and aortic arch or a portion of the aortic orifice of the left ventricle.
The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once.
A fascicle that is part of a spinal cord.
A delimited region of dense mesenchyme within looser mesenchyme.
Cell condensation that is an aggregation of mesenchymal cells that are committed to differentiate into chondroblasts and chondrocytes.
A delimited region of dense mesenchyme within looser mesenchyme whose cells are committed to become chondroblasts.
The paired ventral prominences formed by bifurcation of the first pharyngeal arches in the embryo; the two prominences unite ventrally and fuse to form the mandible and lower lip.
A subdivision of skeleton that supports pharyngeal arch 2.
Anatomical cluster that is located in the posterior region of the cranium and forms the margin of the foramen magnum and occipital condyles.
Organ with organ cavity, which has as parts a serous membrane and a serous cavity . Examples: pleural sac, pericardial sac, tendon sheath, bursa.[FMA].
Epithelium that derives from the endoderm. Examples: urothelium, transitional epithelium of ureter, epithelium of prostatic gland.[FMA].
Subdivision of skeleton which consists of cranial skeleton, set of all vertebrae, set of all ribs and sternum[FMA, modified].
An outflow tract that is part of a cardiac atrium.
Anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk.
Anterosuperior fibrous portion of the left ventricle that connects to the ascending aorta.
Outflow part of atrium which consists of wall and cavity of the outflow part of right atrium and the tricuspid valve.[FMA].
An outflow tract of atrium that is part of a left atrium.
The vertical crest of the interior wall of the right atrium that lies to the right of the sinus of the vena cava and separates this from the remainder of the right atrium.
Any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation.
The wall of the heart that separates the right atrium and left ventricle; and is located just above the septal cusp of the tricuspid valve.
The paired arteries that carry blood to the yolk sac from the dorsal aorta.
Development notes:; the vitelline arteries give rise to the celiac artery, superior mesenteric artery, and inferior mesenteric artery in the adult[MP:0010664]
Anatomical structure embedded in or located in the integument that is part of the integumental system. Examples: hair, follicles, skin glands, claws, nails, feathers.
A threadlike extension of a nerve cell and consists of an axon and myelin sheath (if it is myelinated) in the nervous system. There are nerve fibers in the central nervous system and peripheral nervous system. A nerve fiber may be myelinated and/or unmyelinated. In the central nervous system (CNS), myelin by oligodendroglia cells is formed. Schwann cells form myelin in the peripheral nervous system (PNS). Schwann cells also make a thin covering in an axon without myelin (in the PNS). A peripheral nerve fiber contains an axon, myelin sheath, schwann cells and its endoneurium. There are no endoneurium and schwann cells in the central nervous system.
Axons of neurons encased in a lipoproteinaceous material called myelin. (MeSH).
The spiral septum that separates the truncus arteriosus into a ventral pulmonary trunk and the dorsal aorta[MP]. The aorticopulmonary septum is developmentally formed from neural crest, specifically the cardiac neural crest, and actively separates the aorta and pulmonary arteries and fuses with the interventricular septum within the heart during development. The actual mechanism of septation of the outflow tract is poorly understood, but is recognized as a dynamic process with contributions from contractile, hemodynamic, and extracellular matrix interactions.
The thin bilaminar membrane derived from the prechordal plate that is devoid of mesoderm and formed by the apposition of the stomodeal ectoderm with the foregut endoderm; after the embryonic head fold has evolved it lies at the caudal limit of the stomodeum, forming a septum between the primitive mouth and pharynx; the membrane eventually disappears, and thus a communication is established between the mouth and the future pharynx.
The foremost region of the future forebrain that develops into the diencephalon.
A tendon that has the potential to develop into a central tendon.
cranial derivative of septum transversum
A presumptive structure that has the potential to develop into a forebrain.
the collection consisting of the two lateral swellings and the medial swelling
An anatomical junctions that overlaps the mouth and foregut.
The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord.
A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot.
The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus.
Each of the canals that links the peritoneal cavity and the caudal part of a pleural cavity.
Multi-tissue structure that is part of the heart tube and will become the cardiac ventricle.
presumptive cardiac ventricle heart tube
The embryonic ventricle or primitive ventricle of the developing heart gives rise to the trabeculated parts of the left and right ventricles. In contrast, the smooth parts of the left and right ventricles originate from the embryological bulbus cordis. The primitive ventricle becomes divided by a septum, the septum inferius or ventricular septum, which grows upward from the lower part of the ventricle, its position being indicated on the surface of the heart by a furrow. Its dorsal part increases more rapidly than its ventral portion, and fuses with the dorsal part of the septum intermedium. For a time an interventricular foramen exists above its ventral portion, but this foramen is ultimately closed by the fusion of the aortic septum with the ventricular septum[WP]
See: https://github.com/obophenotype/mouse-anatomy-ontology/issues/13 and https://github.com/obophenotype/uberon/issues/693 -- consider merging into trigeminal ganglion, as this complicates the model
A segment of the eyeball that is filled with refractive media.
Body substance in a liquid or semi-solid state in the eyeball which serves to refract light.
Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not.
A nucleus of brain that is part of a brainstem.
An artery that connects two larger arteries.
A portion of organism substance that secreted_by a zone of skin.
A portion of organism substance that is secreted by a female reproductive gland.
female reproductive system fluid/secretion
A portion of organism substance that secreted_by a respiratory system.
The pharynx is the part of the digestive system immediately posterior to the mouth[GO].
Tunica media of artery which is continuous with the myocardium of right ventricle.[FMA].
A myocardium that is part of a left ventricle of a heart.
A myocardium that is part of a right ventricle of a heart.
A nucleus of brain that is part of a diencephalon.
Presumptive structure of the blastula that will develop into endoderm.
Portion of embryonic tissue determined by fate mapping to become a structure.
Presumptive structure of the blastula that will develop into ectoderm.
Presumptive structure of the blastula that will develop into mesoderm.
A cartilaginous joint that connects left and right mandibles/dentary bones. Mandibular symphysis is unpaired[TAO,modified].
On the interior surface of the temporal bone, behind the rough surface of the apex, is the large circular aperture of the carotid canal, which ascends at first vertically, and then, making a bend, runs horizontally forward and medialward. It transmits into the cranium, the internal carotid artery, and the carotid plexus of nerves. Sympathetics to the head also pass through the carotid canal. They have several motor functions: raise the eyelid (superior tarsal muscle), dilate pupil, innervate sweat glands of face and scalp and constricts blood vessels in head[WP].
The three-lobed cloverleaf-shaped aponeurosis situated at the center of the diaphragm; the central tendon is fused with the fibrous pericardium that provides attachment for the muscle fibers.
An anatomical boundary that adjacent_to a epithelium.
The hypoglossal canal is a bony canal in the occipital bone of the skull.
During the third week of embryological development there appears, immediately behind the ventral ends of the two halves of the mandibular arch, a rounded swelling named the tuberculum impar, which was described by His as undergoing enlargement to form the buccal part of the tongue. More recent researches, however, show that this part of the tongue is mainly, if not entirely, developed from a pair of lateral swellings which rise from the inner surface of the mandibular arch and meet in the middle line. The site of their meeting remains post-embryonically as the median sulcus of the tongue. The tuberculum impar is said to form the central part of the tongue immediately in front of the foramen cecum, but Hammar insists that it is purely a transitory structure and forms no part of the adult tongue[WP, Gray's].
The thyroid initially develops caudal to the tuberculum impar . This embryonic swelling arises from the first pharyngeal arch and occurs midline on the floor of the developing pharynx, eventually helping form the tongue as the 2 lateral lingual swellings overgrow it. [http://emedicine.medscape.com/article/845125-overview]
During the third week there appears, immediately behind the ventral ends of the two halves of the mandibular arch, a rounded swelling named the tuberculum impar, which was described by His as undergoing enlargement to form the buccal part of the tongue. More recent researches, however, show that this part of the tongue is mainly, if not entirely, developed from a pair of lateral swellings (or distal tongue bud) which rise from the inner surface of the mandibular arch and meet in the middle line.
The edge of the cornea where it joins the sclera; the limbus is a common site for the occurrence of corneal epithelial neoplasm.
This location has parts such as blood vessels etc. See PMC2868485, http://www.ncbi.nlm.nih.gov/pubmed/2695343
An epithelium that is composed primarily of secretory cells.
Loose connective tissue located at the outer and inner layers of organs. Examples: submucosal connective tissue, tunica adventitia of artery, papillary dermis, superficial fascia of dorsum of hand.
An anatomical space that surrounded_by a trachea.
A subdivision of a the reproductive tract in a female organism that is the site of embryo development.
Surface groove is modelled as immaterial - see https://github.com/obophenotype/uberon/issues/2667 for discussion
A head mesenchyme that develops_from a mesoderm.
Mesenchyme that is part of a mandibular prominence.
An anatomical space that surrounded_by a digestive tract.
An epithelium characterised by its most superficial layer consisting of squamous epithelial cells.
Multilaminar epithelium which consists of more than one layer of squamous cells only one layer of which is in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, epithelium of wall of esophagus.[FMA].
A squamous epithelium that is part of a tongue.
A squamous epithelium that is part of a esophagus.
A squamous epithelium that is part of a stomach.
A glandular epithelium that lines the stomach. The stomach's glandular epithelium is characterized by the presence of gastric glands.
Any gland that is part of the digestive system.
Simple columnar epithelium that constitutes the secretory part of a gland. Examples: epithelium of stomach, luminal epithelium of lactiferous duct.[FMA].
Stomach mucosa that is lined with glandular epithelium and part of a stomach glandular region.
stomach glandular region glandular mucous membrane
Simple columnar epithelium made up of cells specialized to serve as sensory cells for the reception of external stimuli, as the sensory cells of the cochlea, vestibule, nasal mucosa, and tongue.
The stroma of the ovary is a peculiar soft tissue, abundantly supplied with blood vessels, consisting for the most part of spindle-shaped cells with a small amount of ordinary connective tissue. These cells have been regarded by some anatomists as unstriped muscle cells, which, indeed, they most resemble; by others as connective-tissue cells. On the surface of the organ this tissue is much condensed, and forms a layer composed of short connective-tissue fibers, with fusiform cells between them. The stroma of the ovary may contain interstitial cells resembling those of the testis.
The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis[GO]. The vascular cord is composed of angioblast or vascular endothelial cells in a solid linear mass called a cord. The cord then undergoes tubulogenesis to form the lumen of the vessels[ZFA].
A capillary that is part of the coronary system.
A two dimensional anatomical structure that is the boundary between an anatomical structure and an anatomical substance, an anatomical space or the organism's environment. Examples include the surface of your skin, the surface of the lining of your gut; the surface of the endothelium of you aorta that is in contact with blood.n.
Old definition: 'Non-material anatomical entity of two dimensions, that is demarcated by anatomical lines or points on the external or internal surfaces of anatomical structures.' Note, in the new definition, the space referred to is not necessarily an anatomical space. It may be the outside of an organism.
The splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium[web]. Two migratory heart primordia that move ventrally during the course of neurulation, and then fuse[XAO].
Cranial neural crest that migrates into the mandibular arch.
Cranial neural crest that migrates into the hyoid arch.
A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified].
A pharyngeal pouch that is between pharyngeal arches 1 and 2.
A pharyngeal puch that is between the pharyngeal arches 2 and 3.
A pharyngeal pouch that between pharyngeal arches 3 and 4.
An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section.
An internal carotid artery that branching_part_of a left common carotid artery plus branches.
An internal carotid artery that branching_part_of a right common carotid artery plus branches.
A mesothelium that is part of a serous pericardium.
The stroma of the bone marrow is all tissue not directly involved in the primary function of hematopoiesis. The yellow bone marrow belongs here, and makes the majority of the bone marrow stroma, in addition to stromal cells located in the red bone marrow. Yellow bone marrow is found in the Medullary cavity. Still, the stroma is indirectly involved in hematopoiesis, since it provides the hematopoietic microenvironment that facilitates hematopoiesis by the parenchymal cells. For instance, they generate colony stimulating factors, affecting hematopoiesis.
The structure from the trachea, bronchi, and bronchioles that forms the airways that supply air to the lungs. The lining of the tracheobronchial tree consists of ciliated columnar epithelial cells.
The vasculature consisting of brachiocephalic arteries and veins.
Mesenchyme that develops_from a cranial neural crest.
head mesenchyme from cranial neural crest
mesenchyme derived from head neural crest
Mesenchyme that develops_from a trunk neural crest.
mesenchyme derived from trunk neural crest
A tunica media that is part of a artery.
A tunica adventitia that is part of a artery.
A tunica adventitia that is part of a vein.
Gray matter of the central nervous system which is a collection of clustered nuclei.
Any of the nuclei that comprise the superior olivary complex (superior olive). This includes both the primary nuclei such as the lateral and medial nuclei, as well as periolivary nuclei.
A pre-cartilage condensation that is part of a trachea.
Any collection of muscles that is part of a pectoral appendage.
Any collection of muscles that is part of an appendage.
Skeletal subdivision consisting of the anterior appendicular limb skeleton, excluding the pectoral girdle.
The rhombencephalon (or hindbrain) is a developmental categorization of portions of the central nervous system in vertebrates. The rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. In the human embryo eight rhombomeres can be distinguished, from caudal to rostral: Rh7-Rh1 and the isthmus (the most rostral rhombomere). A rare disease of the rhombencephalon, 'rhombencephalosynapsis' is characterized by a missing vermis resulting in a fused cerebellum. Patients generally present with cerebellar ataxia. The caudal rhombencephalon has been generally considered as the initiation site for neural tube closure.
Portion of tissue that is part of the heart tube and will become the sinus venosus.
A presumptive structure that has the potential to develop into a endocardium.
Embryonic structure that gives rise to the midbrain hindbrain boundary.
A presumptive structure that has the potential to develop into a presomitic mesoderm.
A presumptive structure that has the potential to develop into a neural plate.
The part of the blastula that has the potential to develop into a paraxial mesoderm.
A presumptive structure that has the potential to develop into a forebrain-midbrain boundary.
A blood vessel that is part of a pectoral appendage.
A blood vessel that is part of a limb/fin.
A vasculature that is part of a pectoral appendage.
A vasculature that is part of a chordate pharynx.
A vasculature that is part of a limb/fin.
An anatomical surface that is part of a tongue.
The epidermis is the entire outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species[GO].
Outermost layer of cells surrounding the embryo.
A cartilage tissue that is part of a paired limb or fin.
A cartilage tissue that is part of a pectoral appendage.
A nucleus of brain that spans a midbrain tegmentum.
A tissue whose predominant feature is extracellular matrix which may or may not be highly hydrated or calcified.
An epithelial tube that is open at one end only.
An epithelial tube open at both ends that allows fluid flow.
Mesenchyme with little extracellular matrix.
Simple columnar epithelium in which the luminal side of the cells bears cilia. Examples: epithelium of trachea, epithelium of uterine tube.[FMA].
Epithelium bearing vibratile cilia on the free surface.
A thin, loose vascular connective tissue that makes up the membranes surrounding joints and the sheaths protecting tendons (particularly flexor tendons in the hands and feet) where they pass over bony prominences. Synovial tissue contains synovial cells, which secrete a viscous liquid called synovial fluid; this liquid contains protein and hyaluronic acid and serves as a lubricant and nutrient for the joint cartilage surfaces[BTO]. Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow[BTO].
An anatomical cavity that surrounded_by a synovial joint.
cavitas articularis (junctura synovialis)
Epithelial layer of the retina, ciliary body, or iris composed of cells containing pigment granules.
A neural nucleus that is part of a medulla oblongata.
The sensory trigeminal nerve nuclei are the largest of the cranial nerve nuclei, and extend through the whole of the midbrain, pons and medulla. There is also a distinct trigeminal motor nucleus that is medial to the chief sensory nucleus[WP].
A developing mesenchymal capsule that covers the developing brain and spinal cord and is the precursor of the meningeal cluster. In mammals this gives rise to the arachnoid mater, pia mater and dura mater. In cyclostomes and fishes, the future meninx gives rise to a single meningeal layer, the primitive meninx.
The outermost layer of the mesenchymal capsule that surrounds the developing brain, of mixed paraxial mesoderm and neural crest origin. The ectomeninx forms the dura mater (both inner layer and outer chondrogenic layer).
An anatomical structure that connects two structures.
Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue.
relation conflict: ZFA vs EHDAA2. Note EHDAA2 term renamed to 'early PA endoderm'
The minute opening of a taste bud on the surface of the oral mucosa through which the gustatory hairs of the specialised neuroepithelial gustatory cells project.
A bone that is part of a reproductive organ.
Any bodily fluid that has passed through a membrane such as the capillary wall, as a result of unbalanced hydrostatic and osmotic forces.
Anatomical system that consists of all blood and lymph vessels.
Adipose tissue that is located in the abdominal region. This includes any subcutaneous fat, visceral fat or encapsulated adipose tissue depots.
The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae.
An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc).
A bone that is part of a appendage girdle region.
A bone that is part of a pectoral girdle region.
A subdivision of a limb or fin skeleton consisting of bones which connects the upper limb or fin to the axial skeleton on each side. It consists of the clavicle and scapula in humans and, in those species with three bones in the pectoral girdle, the coracoid. Some mammalian species (e.g. the dog and the horse) have only the scapula. In humans, the only joints between the shoulder girdle and axial skeleton are the sternoclavicular joints on each side. No joint exists between each scapula and the rib cage; instead the muscular connection between the two permits relatively great mobility of the shoulder girdle in relation to the pelvic girdle. In those species having only the scapula, no joint exists between the forelimb and the thorax, the only attachment being muscular[WP]. Examples: There are only two instances, right and left pectoral girdle skeletons.
Bone element that arises as a result of intramembranous ossification.
Skeletal element that is composed of cartilage tissue and may be permanent or transient.
Connective tissue, which consists of fibroblasts, the intercellular matrix of which contains a regular network of collagen and elastic fiber bundles. Examples: bone (tissue), cartilage (tissue), dense regular connective tissue.
Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts).
dense regular collagenous connective tissue
typus regularis (textus connectivus collagenosus compactus)
A bone that is part of a craniocervical region.
The irregular bones are bones which, from their peculiar form, cannot be grouped as long bone, short bone, flat bone or sesamoid bone. Irregular bones serve various purposes in the body, such as protection of nervous tissue, affording multiple anchor points for skeletal muscle attachment (as with the sacrum), and maintaining pharynx and trachea support, and tongue attachment (such as the hyoid bone). They consist of cancellous tissue enclosed within a thin layer of compact bone. The irregular bones are: the vertebrC&, sacrum, coccyx, temporal, sphenoid, ethmoid, zygomatic, maxilla, mandible, palatine, inferior nasal concha, and hyoid.
A skeletal joint that is part of a appendage girdle region.
An anatomical surface that is part of a cartilage element.
A bone that is hollow or contains many air cells, such as the mastoid process of the temporal bone[TMD].
Any muscle organ that is part of a pectoral girdle region.
Musculature system of the pharyngeal and head regions.
Subdivision of thorax, which in humans is the posterior part of the thorax and is demarcated from the chest by the external surface of the posterolateral part of the rib cage and the anterior surface of the thoracic vertebral column; together with the chest, it constitutes the thorax.
A muscle of back that is part of a dorsal thoracic segment of trunk.
An endothelium that is part of a heart [Automatically generated definition].
Epithelium pertaining to the trachea and bronchi.
An embryonic structure that is derived from the inner cell mass and lies above the hypoblast and gives rise to the three primary germ layers.
The epiblast cells (appearing on day 8 of human embryonic development) make up a columnar epithelium with dense microvilli on the apical surface. During gastrulation, the epiblast cells undergo epithelial-to-mesenchymal transition and delaminate to become the loose mesenchyme of the primitive streak. The epiblast is present in postimplantation mouse embryos between E5.5-E7.5.
A transient embryonic complex that comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming, which may include (depending on species) the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear[GO,modified].
A brain that develops_from a neural tube.
Closed space within the ectoplacental cone, formed by the fusion of the parts of the amniotic fold that separate it from the amniotic cavity[MP]. a developmental cavity that exists in some mammals and is derived by division of the proamniotic space; it is further removed from the embryo than the amniotic cavity in some mammals.
Any skeletal muscle organ in the hypodermis / superficial fascia.
Bone tissue that is an unmineralized bone matrix deposited by osteoblasts prior to the mineralization of bone tissue.
The part of the cardiovascular system consisting of all pulmonary arteries and all pulmonary veins.
Subdivision of endoskeleton derived from pharyngeal arches.
A pharyngeal arch that is posterior to the hyoid arch. i.e. any pharyngeal arch with a number 3 or higher.
Skeletal element that forms superficially in the organism, usually in association with the ectoderm[VSAO].
Bone element that is adjacent to the notochord.
System pertaining to blood vessels in the brain.
A zone of skin that is part of a dorsal thoracic segment of trunk.
Vein that drains left lung and returns blood to the heart.
Vein that drains right lung and returns blood to the heart.
A gonad prior to differentiating into a definitive testis or ovary.
typically part of the embryo - however, in male tammar wallabies the gonads are indifferent at the neonatal stage[8827321]
Epibranchial placode between geniculate and nodose. Associated with 2nd branchial cleft.
Taxonomic equivalence to EHDAA2 class made on basis of shared development: gives rise to glossopharyngeal ganglion
Cranial ganglion which develops from an epibranchial placode.
Epibranchial ganglia orchestrate the development of the cranial neurogenic crest
Endocardium that is part of the right atrium.
A fold of tissue which extends into the peritoneal cavity of the developing embryo and participates in the separation of the pleural and peritoneal cavities.
A vein that is part of a craniocervical region.
Any suture between cranial and/or facial bones.
The superior surface of the tongue divided by the sulcus terminalis into an anterior two-thirds, the presulcal part (pars presulcalis). and a posterior one-third, the postsulcal part (pars postsulcalis).
An ectoderm that is part of a buccopharyngeal membrane.
An endoderm that is part of a buccopharyngeal membrane.
A portion of mesenchymal tissue associated with an individual pharyngeal arch.
Mesenchyme that is part of a developing trachea.
An epithelium that is part of a lateral lingual swelling.
A sulcus limitans of neural tube that is part of a future spinal cord.
spinal cord lateral wall sulcus limitans
A sulcus limitans of neural tube that is part of a future medulla oblongata.
A sulcus limitans of neural tube that is part of a future metencephalon.
A sulcus limitans of neural tube that is part of a future myelencephalon.
Mesenchyme that is part of a 1st arch mandibular component.
mesenchymal region of mandibular component of first pharyngeal arch
Mesenchyme that is part of a developing left lung.
Mesenchyme that is part of a developing right lung.
A neural plate that develops_from a future forebrain.
A neural plate that develops_from a presumptive midbrain.
A neural plate that develops_from a presumptive hindbrain.
midbrain-hindbrain boundary neural plate
midbrain hindbrain boundary neural plate
A presumptive structure that has the potential to develop into a midbrain.
Bilateral mesenchymal mesoderm parallel and immediately adjacent to the neural tube/notochord; it generates a subset of extra-ocular, and other head, muscles.
A basement membrane that is part of a bronchus.
A basement membrane that is part of a trachea.
A nucleus of brain that is part of a telencephalon.
Any endocardium that is part of the right ventricle of the heart.
Any endocardium that is part of the left ventricle of the heart.
An anatomical cavity that surrounded_by a stomodeum.
The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing cardiac structures.
A ganglion that is part of a abdominal segment of trunk.
A serous sac that has the pleura and the pleural cavity as parts.
The many-lobed berry cluster of cells that is the terminous of a gland where the secretion is produced is acinar in form.
Branch or outpocketing of the digestive tract.
A division of the stomach. The stomach can be divided based on mucosal histology (glandular epithelium and gastric glands) and the relative position and type of gastric gland.
A specific region of the lateral mesoderm that will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract).
Mesenchyme that is part of a developing face.
A multicellular organism that existence_starts_with a post-embryonic stage.
Cranial ectodermal placode with potential to develop into a component of the nervous system, such as nerves or ganglia.
An anatomical structure that has more than one cell as a part.
A regional part of brain consisting of multiple brain regions that are not related through a simple volummetric part of hierarchy, e.g., basal ganglia[NIF].
Mesenchyme that is part of a pharyngeal arch 6.
The portion of the tongue in front of the terminal sulcus. At the apex, thin and narrow, it is directed forward against the lingual surfaces of the lower incisor teeth. It is derived primarily from the first pharyngeal arch.
An organ of the digestive tract that is capable of retaining and storing food.
Mesenchyme that is part of a pharyngeal arch 1.
The sum total of mesenchymal tissue in the pharyngeal arch region. Pharyngeal mesenchyme is undifferentiated, loose connective tissue derived mostly from mesoderm, and also contains ectodermally derived neural crest cells.
associated mesenchyme of pharyngeal region
entire branchial arch associated mesenchyme
entire pharyngeal arch associated mesenchyme
Gland of the epithelium lining the oral cavity. The most common are the salivary glands.
A mucosa that is part of a dorsum of tongue.
A compound organ that has the potential to develop into a tongue.
An anatomical space with at least one opening to another space or the exterior.
One of the 5 distinct and partially overlapping functional domains of the premigratory neural crest. The vagal and sacral neural crest cells develop into the ganglia of the enteric nervous system, also known as the parasympathetic ganglia.
An epithelium consisting of cuboidal epithelial cells.
Mesenchyme that has the potential to develop into a dermis.
A structure that will develop into a diaphragm.
A multi-tissue structure that has the potential to develop into a meninx of hindbrain.
A developing anatomical structure that has the potential to develop into a metencephalon.
A developing anatomical structure that has the potential to develop into a myelencephalon.
A gray matter that has the potential to develop into a superior salivatory nucleus.
Any portion of cardiac muscle tissue that is part of the conducting system of heart or the Purkinje fibers.
An epithelial sheet is a flat surface consisting of closely packed epithelial cells.
An anatomical cavity that surrounded_by a blood vessel.
One of the laterally paired arteries that supply the gonads.
An anatomical boundary that corresponds to some physical discontinuity.
One might argue that all boundaries are actually fiat in the sense that there must be some fiat element at a fine enough scale of granularity. This ontology choses to ignore this issue as below the level of granularity relevant to anatomy. (DOS121102)
Apparatus located between the lungs and the buccal cavity. This apparatus is composed of a pair of arytenoid cartilages that are supported by the cricoid ring.
Many sources say: thyroid cartilage from arch 4 other laryngeal cartilage (cricoid/arytenoid) from 6?
A nuclear complex which in mammals consists of four parts, the hypothalamus, epithalamus, ventral thalamus, and dorsal thalamus[WP,modified].
Multi-tissue structure that is part of the heart tube and will become the cardiac atrium.
The core globe-shaped component of the camera-type eye.
An exocrine gland whose secretions are excreted via exocytosis from secretory cells into an epithelial-walled duct or ducts and thence onto a bodily surface or into the lumen; the gland releases its product and no part of the gland is lost or damaged.
Mesenchyme that develops_from a neural crest and is part of a 1st arch mandibular mesenchyme.
1st arch mandibular mesenchyme from neural crest
Mesenchyme that develops_from a neural crest and is part of a 2nd arch mesenchyme.
pharyngeal arch 2 mesenchyme from neural crest
branchial arch 2 mesenchyme from neural crest
Mesenchyme that develops_from a neural crest and is part of a 3rd arch mesenchyme.
3rd pharyngeal arch mesenchyme derived from neural crest
mesenchyme derived from neural crest of mesenchyme of 3rd arch
pharyngeal arch 3 mesenchyme from neural crest
branchial arch 3 mesenchyme from neural crest
Mesenchyme that develops_from a neural crest and is part of a 4th arch mesenchyme.
4th pharyngeal arch mesenchyme derived from neural crest
mesenchyme derived from neural crest of mesenchyme of 4th arch
pharyngeal arch 4 mesenchyme from neural crest
branchial arch 4 mesenchyme from neural crest
Mesenchyme that develops_from a neural crest and is part of a 6th arch mesenchyme.
pharyngeal arch 6 mesenchyme from neural crest
branchial arch 6 mesenchyme from neural crest
Mesenchyme that develops_from a rhombencephalon neural crest.
mesenchyme from rhombencephalic neural crest
Mesenchyme that develops_from a neural crest and is part of a 1st arch mesenchyme.
mesenchyme derived from neural crest of mesenchyme of 1st arch
pharyngeal arch 1 mesenchyme from neural crest
branchial arch 1 mesenchyme from neural crest
A group of bones comprised of hyoid body and two pairs of cornua (i.e. greater cornua and lesser cornua), and lies just below the tongue, above the thyroid cartilage.
Portion of tissue that is dorsolateral to the floor plate and part of the midbrain.
Portion of neural tube that gives rise to the midbrain.
An endothelium that is part of a sclera.
Mesenchyme surrounding the developing optic cup which develops into the sclera.
An epithelium that is part of a extraembryonic structure.
Developing anatomical structure that develops into the eyeball and associated structures.
An anatomical structure that develops from the neural crest.
An anatomical structure that has some part that develops from the neural crest.
structure with developmental contribution from neural crest
A skeletal element that is part of a orbital region.
Skeletal subdivision of the head including skull (cranium plus mandible), pharyngeal and/or hyoid apparatus.
Mesenchyme that is part of a limb/fin bud.
Mesenchyme that is part of a extraembryonic membrane.
Mesenchyme that develops_from a neural crest and is part of a mandibular process mesenchyme.
mandibular process mesenchyme from neural crest
Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a mandibular process mesenchyme.
mandibular process mesenchyme from head mesenchyme
Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mandibular mesenchyme.
1st arch mandibular mesenchyme from head mesenchyme
Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mesenchyme.
mesenchyme derived from head mesoderm of mesenchyme of 1st arch
1st arch mesenchyme from head mesenchyme
Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 2nd arch mesenchyme.
head mesenchyme derived arch 2 mesenchyme
mesenchyme derived from head mesoderm of mesenchyme of 2nd arch
pharyngeal arch 2 mesenchyme from head mesenchyme
branchial arch 2 mesenchyme from head mesenchyme
2nd arch mesenchyme from head mesenchyme
Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 3rd arch mesenchyme.
head mesenchyme derived arch 3 mesenchyme
mesenchyme derived from head mesoderm of mesenchyme of 3rd arch
pharyngeal arch 3 mesenchyme from head mesenchyme
branchial arch 3 mesenchyme from head mesenchyme
3rd arch mesenchyme from head mesenchyme
Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 4th arch mesenchyme.
head mesenchyme derived arch 4 mesenchyme
mesenchyme derived from head mesoderm of mesenchyme of 4th arch
pharyngeal arch 4 mesenchyme from head mesenchyme
branchial arch 4 mesenchyme from head mesenchyme
4th arch mesenchyme from head mesenchyme
Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 6th arch mesenchyme.
head mesenchyme derived arch 6 mesenchyme
pharyngeal arch 6 mesenchyme from head mesenchyme
branchial arch 6 mesenchyme from head mesenchyme
6th arch mesenchyme from head mesenchyme
Mesenchyme that develops_from a neural crest and is part of a entire pharyngeal arch associated mesenchyme.
branchial arch mesenchyme from neural crest
Partially implements https://github.com/obophenotype/uberon/wiki/The-neural-crest NC meeting scheme
pharyngeal arch mesenchyme from neural crest
Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a entire pharyngeal arch associated mesenchyme.
branchial arch mesenchyme from head mesenchyme
pharyngeal arch mesenchyme from head mesenchyme
Skeletal subdivision that undergoes indirect development and includes elements that develop as a replacement or substitution of other elements or tissues.
A skeletal element that has the potential to participate in endochondral ossification, and may participate in intramembranous ossification.
Skeletal subdivision that undergoes direct development and includes elements that either develop in association with the basement membrane of the ectoderm or are homologous with such elements; includes dermatocranium, components of the appendicular skeleton, teeth and tooth-like elements of the oropharynx, and integumentary elements.
This ontology covers metazoa, so we do not use exoskeleton as primary label, as in VSAO
Epithelium composed of cells that develops from the ectoderm[FMA,modified].
Mesenchyme that develops_from a somatopleure.
Mesenchyme that develops_from a splanchnopleure.
The integrated unit (of the eye) that consists of the conjunctiva, the corneal surface, and the ocular mucosal adnexa including the lid margins and the meibomian gland openings, the lacrimal glands and the lacrimal drainage system, all which are critical to maintain ocular surface integrity and provide protection from external antigens and pathogenic microorganisms.
The ciliary processes are formed by the inward folding of the various layers of the choroid, i.e. , the choroid proper and the lamina basalis, and are received between corresponding foldings of the suspensory ligament of the lens.
A bone that is shaped as a broad flat plate and composed of two thin layers of compact tissue enclosing between them a variable quantity of cancellous tissue, which is the location of red bone marrow.
Examples: cranium, the ilium, sternum, rib cage, the sacrum and the scapula; the occipital, parietal, frontal, nasal, lacrimal, vomer, scapula, os coxC&, sternum, and ribs
A simple columnar epithelium that looks stratified but is not, because its cells are arranged with their nuclei at different levels.
Epithelium composed of a single layer of cells, appearing as layered because the column-shaped cells vary in height so the nuclei are at different levels. The basal portions of all the cells are in contact with the basement membrane. It lines the respiratory system and the male reproductive tract. The cilia in the respiratory tract are motile, while the stereocilia in the male reproductive tract are immobile.
epithelium pseudostratificatum columnare ciliatum (trachea et bronchi)
pseudostratified ciliated columnar epithelium
Skeletal element that forms as a replacement or substitution of another element or tissue.
A vessel of the microcirculature, lying between the arterioles and venules; includes capillaries (blood and lymphatic), metarterioles and arteriovenous anastomoses.
An organ cavity that surrounded_by a bone.
An organism subdivision that includes both an appendage and its associated girdle region. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc).
Appendage girdle complex that when present, encompasses the pectoral appendicular skeleton and the pectoral girdle.
pectoral girdle plus anterior limb or fin
pectoral girdle plus pectoral limb or fin
The subdivision of the skeleton of either the pectoral or pelvic girdle.
A bone that is part of an appendage girdle complex (i.e. any bone in a limb, fin or girdle).
A bone that is part of a pectoral complex. Examples: scapula, manus phalanx, any carpal bone, any bone of the pectoral fin.
bone of forelimb or pectoral fin or pectoral girdle
The collection of all meningeal layers that line a central nervous system.
A muscle of a pectoral girdle, pectoral fin or anterior limb.
Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints.
Any muscle organ that is part of either the head or the neck.
A cartilage element that is part of a splanchnocranium.
A synovial joint that is part of a pectoral girdle region.
A skeletal joint that connects a laryngeal cartilage.
Joint in which the articulating bones or cartilages are connected by ligaments or fibrocartilage without an intervening synovial cavity. Examples: sagittal suture, inferior tibiofibular syndesmosis, costochondral joint, pubic symphysis.
Subdivision of the skeletal system which consists of the axial skeleton plus associated joints.
Subdivision of the skeletal system which consists of the postcranial axial skeleton plus associated joints.
Subdivision of skull that consists of the facial bones.
The skull can be divided into two: the neurocranium and the facial skeleton.
primary subdivision of cranial skeletal system
A bone that is part of a neurocranium [Automatically generated definition].
A multi cell part structure that is part of a central nervous system.
central nervous system cell part cluster
Synovial sac which surrounds parts of one or more tendons. Examples: synovial tendon sheath of manual digit 2, radial bursa.
Alternate def: A synovial sheath is a layer of a tendon sheath containing tendons in the hand and foot. They lie internal to the fibrous tendon sheaths. An example is the common synovial sheath for the flexor tendons. [Wikipedia:Synovial_sheath]
synovial membrane of synovial tendon sheath
fibrous membrane of synovial tendon sheath
Subdivision of the skeletal system which consists of the appendicular skeleton plus associated joints.
The part of the trunk that is in the dorsum[cjm].
A partion of white matter that is part of a telencephalon. This can be further subdivided in some species, for example, into hemisphere white matter and the corpus callosum.
predominantly white regional part of telencephalon
A portion of gray matter that is part of a telencephalon.
predominantly gray regional part of telencephalon
A blood vasculature that is part of a head.
An anatomical cavity that is part of a esophagus.
The collection of all skeletal elements in an individual limb or fin.
Anatomical structure that is an aggregation of similar cells from which cartilages and bones form, and from which chondrogenesis and osteogenesis are initiated during repair and/or regeneration. (Hall and Miyake 1995).
A subdivision of the head that corresponds to the jaw skeleton, containing both soft tissue, skeleton and teeth (when present). The jaw region is divided into upper and lower regions.
An epithelium that develops_from a ectoderm and is part of a oral epithelium.
A major subdivision of an organism that divides an organism along its main body axis (typically anterio-posterior axis). In vertebrates, this is based on the vertebral column.
subdivision of organism along main body axis
A cardiovascular system that is part of a conceptus.
vagus X nerve left recurrent laryngeal branch
vagus X nerve right recurrent laryngeal branch
An anatomical space that is part of a bone of lower jaw.
A cranial nerve nucleus that is associated with a vagus nerve.
A neural nucleus that is part of the spinal cord.
Ectodermal placode that does not develop into a component of the nervous system.
An anatomical junction that divides and overlaps with and atrium and a ventricle in the heart.
Connective tissue, which consists of a population of connective tissue cells, the intercellular matrix of which contains an irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, mucoid tissue, connective tissue of peritoneum, connective tissue of fibrous pericardium.
Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium.
typus irregularis (textus connectivus collagenosus compactus)
Dense connective tissue is mainly composed of collagen type I. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that manufacture the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets.
Irregular connective tissue, the intercellular matrix of which contains a sparse irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, neuroglial tissue, mucoid tissue.
An acinus that is part of a exocrine gland.
The connective tissue bundles in the extracellular matrix of aorta tissue that are composed of collagen, and play a role in tissue strength and elasticity.
The connective tissue bundles in the extracellular matrix of pulmonary tissue that are composed of collagen, and play a role in tissue strength and elasticity.
The connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity.
The connective tissue bundles in the extracellular matrix of tendon tissue that are composed of collagen, and play a role in tissue strength and elasticity.
The connective tissue bundles in the extracellular matrix of corneal stroma that are composed of collagen, and play a role in tissue strength and elasticity.
Front (ventral) portion of the vascular, pigmentary, or middle coat of the eye, including the ciliary body and the iris.
Epimysium is a layer of connective tissue which ensheaths the entire muscle. It is composed of dense irregular connective tissue. It is continuous with fascia and other connective tissue wrappings of muscle including the endomysium, and perimysium. It is also continuous with tendons where it becomes thicker and collagenous.
Masses of developing blood cells attached to endothelium in the yolk sac.
Nerve fibers which project from the central nervous system to autonomic ganglia. In the sympathetic division most preganglionic fibers originate with neurons in the intermediolateral column of the spinal cord, exit via ventral roots from upper thoracic through lower lumbar segments, and project to the paravertebral ganglia; there they either terminate in synapses or continue through the splanchnic nerves to the prevertebral ganglia. In the parasympathetic division the fibers originate in neurons of the brain stem and sacral spinal cord. In both divisions the principal transmitter is acetylcholine but peptide cotransmitters may also be released.
A cholinergic axonal fiber projecting from the CNS to a sympathetic ganglion.
A cholinergic axonal fibers projecting from the CNS to a parasympathetic ganglion.
A region of the stomach that is lined with glandular epithelium.
The aggregate of the coelemic cavity lumen plus the membranes that line the lumen.
Bone that forms as a replacement of another structural tissue.
An anatomical cavity that is part of a bronchus.
A primordium that has the potential to develop into a stomach.
A zone of skin that is part of a craniocervical region.
The veins that run parallel to the phrenic arteries which include the two superior and two inferior phrenic veins.
An artery that originates from the abdominal aorta.
An epithelium that consists of columnar epithelial cells. Columnar epithelia are epithelial cells whose heights are at least four times their width. Columnar epithelia are divided into simple (or unilayered), and the rarer stratified (or multi-layered).[WP, modified].
Epithelium that derives from the mesoderm. [Automatically generated definition].
One of five swellings formed during the development of the face.
The deep cervical artery (Profunda cervicalis) is an artery of the neck.
The transverse cervical artery (transverse artery of neck, transversa colli artery) is a branch of the thyrocervical trunk, running at a higher level than the suprascapular artery.
descending branch of the transverse cervical
A bone element that is part of a jaw region.
A layer of tissue between the muscularis and serosa.
Contains nerves, blood vessels, lymphatics and lymph nodes
respiratory system arterial smooth muscle
A smooth muscle tissue that is part of a respiratory system venous blood vessel.
Blood-forming tissue, consisting of reticular fibers and cells.
The sclera and cornea form the fibrous tunic of the bulb of the eye; the sclera is opaque, and constitutes the posterior five-sixths of the tunic; the cornea is transparent, and forms the anterior sixth.
An anatomical space with no opening to another space or to the exterior.
The collection of all skeletal elements in a pectoral complex - i.e. the combination of free limb or fin plus pectoral girdle.
skeleton of anterior limb/fin and girdle
An adventitia that is part of a esophagus.
The part of the venous system that drains the lungs[Kardong].
Any vein within the general circulation that transports blood back to the right atrium of the heart.
The secretory unit of a serous gland. The acinar portion is composed of serous secreting cells.
Anatomical cavity that is the lumen of the skull and contains the brain.
A blood vessel endothelium that is part of a lung [Automatically generated definition].
The anatomical space that is enclosed by a stomach.
Anatomical space that is an opening in a bone of the skull.
An anatomical space which is the lumen of some anatomical conduit and connects two or more spaces together[FMA,modified].
Vascular endothelium found in blood vessels of the blood-brain-barrier.
Musculature of the head and neck, spine, and ribs.
A principle subdivision of an organism that includes all structures along the primary axis, typically the anterior-posterior axis, from head to tail, including structures of the body proper where present (for example, ribs), but excluding appendages.
The region of the organism associated with the visceral organs.
A tubular passage that extends from the primitive pit into the head process during the early stages of embryonic development in mammals. It perforates the splanchnopleure layer so that the yolk sac and the amnion are connected temporarily.
Fluid contained within the notochordal canal.
An organ component layer that is part of a integumental system.
Any of the organs or elements that are part of the digestive system. Examples: tongue, esophagus, spleen, crop, lunge feeding organ, tooth elements.
Great vessels is a term used to refer collectively to the large vessels that bring blood to and from the heart.
Groupings may vary - typically pulmonary vessels and aorta and vena cavae
Embryonic structure that gives rise to the telencephalon.
paired anteriolateral division of the embryonic prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived[MP]
Mesenchyme that develops_from the neural crest[Automatically generated definition].
A papilla that contain taste buds, including the fungiform, foliate, and circumvallate papillae.
Muscle that is part of the respiratory system.
An anatomical space that is enclosed by a sinusoid.
A part of the body present only in a specific gender.
A part of the body present only in females.
A taste bud that is located on the tongue, situated on a gustatory papilla.
A gustatory epithelium that is part of a tongue.
Subcutaneous adipose tissue that is located in the peritoneal cavity.
Subcutaneous adipose tissue that is located in the abdominal region.
Subdivision of skeletal system that consists of all skeletal elements in the thoracic region of the trunk. In most vertebrates this is the rib cage and sternum.
white matter lamina of cerebral hemisphere
A ventral horn of spinal cord that is part of a thoracic spinal cord.
A gray matter of spinal cord that is part of a cervical spinal cord.
A white matter of spinal cord that is part of a cervical spinal cord.
A ventral horn of spinal cord that is part of a cervical spinal cord.
A gray matter of spinal cord that is part of a thoracic spinal cord.
A white matter of spinal cord that is part of a thoracic spinal cord.
A white matter that is part of a medulla oblongata.
An anatomical space that is enclosed by a pleuroperitoneal canal.
An epithelium that is part of a median lingual swelling.
A neuromere that is part of the presumptive forebrain.
A neuromere that is part of the presumptive midbrain.
A neuromere that is part of the presumptive spinal cord.
The lingual septum consists of a vertical layer of fibrous tissue, extending throughout the entire length of the median plane of the tongue, though not quite reaching the dorsum. It is thicker behind than in front, and occasionally contains a small fibrocartilage, about 6 mm. in length. It is well displayed by making a vertical section across the organ.
Any collection of muscles that is part of a pectoral complex. The pectoral complex comprises the pectoral girdle and the associated limb or fin.
Any muscle organ that is part of a pectoral appendage (forelimb or pectoral fin).
White matter that is part of a brainstem [Automatically generated definition].
A muscle organ that consists of skeletal muscle tissue ensheathed in epimysium, that develops from myotome and that is innervated by some somatic motor neuron. Skeletal muscles are typically attached (via a tendon) to a bone but there are exceptions (e.g. intrinsic tongue muscles).
A portion of tissue that will develop into vasculature.
One of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites.
perimysial connective tissue of subepicardium
Visceral intrapericardial fat contiguous with the myocardial surface.
A gland that is typically found in or near the orbital region, in or around either the medial or lateral canthi, and is typically associated with secretions onto the eyeball or associated ducts. Includes the Harderian, nictitans and lacrimal glands.
An eye consisting of multiple light-sensing organs.
A region of somite adjacent to presomitic mesoderm.
Epithelium located in the intersomitic region.
An anatomical group whose component structures share a common function.
A non-connected functional system that is composed primarily of a gland.
Any structure that is placed on one side of the left-right axis of a bilaterian.
A hollow, muscular organ, which, by contracting rhythmically, contributes to the circulation of lymph, blood or analogs. Examples: a chambered vertebrate heart; the tubular peristaltic heart of ascidians; the dorsal vessel of an insect; the lymoh heart of a reptile.
A basement membrane of epithelium that is part of a respiratory system.
A smooth muscle tissue that is part of a hypodermis.
muscle layer in fatty layer of subcutaneous tissue
smooth muscle layer in fatty layer of subcutaneous tissue
An epithelium that is part of a camera-type eye.
An epithelium that is part of a foregut.
A hole in the diaphragm through which the esophagus passes.
Is the sensory system for the sense of hearing.
Luminal space of the right ventricle of the heart.
Luminal space of the left atrium of the heart.
Luminal space of the left ventricle of the heart.
Luminal space of the right atrium of the heart.
The external part of the developing pharynx that is made of ectoderm. During vertebrate development, pockets form in pharyngeal ectoderm between the pharyngeal arches.
A layer of of the central nervous system that is part of gray matter.
central nervous system gray matter layer
A layer of of the central nervous system that is composed of white matter.
central nervous system white matter layer
A white matter that is part of the midbrain.
Primordium that develops into the central nervous system.
Primordium that develops into the nervous system.
The part of the conceptus that may be lost before birth or will be discarded at birth, or when the embryo becomes an independent organism.
An embryonic anatomical entity that will turn into one or more other anatomical entities, perhaps with other anatomical entities, later in development.
The zone of the skin that surrounds a lip and is colored red due to thin epithelium and presence of eleidin.
A vermilion that is part of a lower lip.
A mesenchyme-derived anatomical entity undergoing a transtion to become another structure.
A zone of skin that is part of a lower lip.
Any portion of submucosa that lines the digestive tract.
Any organ component layer that consists of muscle tissue.
Foramen that allows the passge of the glossopharyngeal nerve (cranial nerve IX).
Muscle innervated by the trigeminal nerve (Cranial Nerve V).
muscle innervated by the trigeminal nerve
An interconnected tubular multi-tissue structure that contains fluid that is actively transported around the heart.
Adipose tissue which is located throughout skeletal muscle and is responsible for the marbling seen in certain cuts of beef. In humans, excess accumulation of intramuscular fat is associated with insulin resistance and type 2 diabetes.
Any region of epithelium that is part of a skin region.
The part of the eye that consists of both the retina and the optic choroid.
A white matter that is part of the hindbrain.
A white matter that is part of the forebrain.
A white matter that is part of the myelencephalon.
predominantly white regional part of pontine tegmentum
An exocrine gland that is part of a integumental system.
The spinal accessory nucleus lies within the cervical spinal cord (C1-C5) in the ventral horn. The nucleus ambiguus is classically said to provide the 'cranial component' of the accessory nerve. However, the very existence of this cranial component has been recently questioned and seen as contributing exclusively to the vagus nerve. The terminology continues to be used in describing both human anatomy, and that of other animals.
accessory nucleus of anterior column of spinal cord
See also: Wikipedia:Spinal_accessory_nucleus
A portion of organism substance that is secreted by a reproductive gland.
Single layer of a laminar structure, identified by different density, arrangement or size of cells and processes arranged in flattened layers or lamina[CUMBO].
Serous membrane layer that is adjacent to and lines an organ.
Serous membrane layer that lines to a body cavity.
A specific region of the foregut into the area in which the lung will develop.
An embryonic or larval epithelium that is committed to form part of the nervous system.
An epithelium that is undergoing proliferation to provide large numbers of neuronal cells.
A neuroepithelium some of whose cells are undergoing terminal differentiation to become neuronal cells.
spinal cord lateral wall ventricular layer
The layer of the developing cerebral cortex that is formed from the first cohort of neurons to migrate out of the cortical ventricular zone; split by the second wave into marginal zone and subplate.
Any of the cranial nerves, or their central nervous system analogs (the optic tract, the epiphyseal tract). These analogs are not true nerves, and are instead evaginated sensory afferents emanating from the brain.
A taste bud that is located external to the digestive tube, on the head or body, as found in species such as goldfish.
A taste bud that is located on the skin of the head.
A taste bud that is located in the pharynx.
A taste bud that is located in the esophagus.
A taste bud that is located on the skin of the trunk.
The autonomic nerve is a small nerve which carries postganglionic sympathetic and parasympathetic neurons from the zygomaticotemporal nerve; a branch of the maxillary nerve, to the lacrimal nerve; a branch of the ophthalmic nerve. These neurons derive from the superior cervical ganglion and the pterygopalatine ganglion respectively. They will travel to the lacrimal gland via the lacrimal nerve. Parasympathetic will induce lacrimation and vice versa.
Any substance in the body or expelled from the body that is in a gaseous state.
Any portion of gas located in a part of the respiratory system that is composed primarily of air.
The area of axial mesoderm that develops into the prechordal plate.
Endocardium that is part of the left atrium.
An multicellular anatomical structure that has subparts of multiple organs as a part.
A cluster of cells, largely surrounded by a morphological boundary.
Material anatomical entity consisting of multiple anatomical structures that are not connected to each other.
A collection of anatomical structures that are alike in terms of their morphology or developmental origin.
A region or zone on the surface of an organism that encompasses skin and any adnexa, down through muscles and bounded by underlying skeletal support structures.
Any organ component layer that consists of smooth muscle tissue.
organ region with floating fiat boundary
Any portion of gas located in a part of the respiratory system.
Mesenchyme that is part of a developing jaw [Automatically generated definition].
Any material entity that is located in the digestive tract. This includes undigested food and liquid as well as unexcreted waste products. It also includes other entities such as ingested stones used to aid digestion. Any microbial cells or cell populations are also included.
Anatomical surface, which is the external surface of the whole body. Examples: There is only one body surface.
Any of several arteries that arise from the aorta and supply blood to the esophagus.
The part of the circulatory system that lies within the subcutaneous tissue layers close to the surface of the skin.
Any of the veins carrying deoxygenated blood from the subcutaneous tissue layers.
The part of the circulatory system that lies deep beneath the subcutaneous tissue layers away from the surface of the skin.
A blood vessel carrying deoxygenated blood far beneath the skin usually accompanying an artery.
Any chamber of the left side of the heart.
Any chamber of the right side of the heart.
The parts of the orbital region that are outside of the the eyeball, including the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva.
The primordial mouth region of the developing head.
The sum of epicardial and paracardial fat deposits.
Fat deposits in the mediastinum outside the parietal pericardium .
Any fat deposit surrounding a visceral organ.
The part of the ventral body cavity that is within the abdominal segment of the trunk, which encompasses the abdomen proper plus pelvic cavity.
A serous sac that is the aggregate of the peritoneum and the peritoneal cavity, located in the abdominal cavity.
respiratory primordium associated mesenchyme
An region of the mesoderm that includes anterior lateral mesoderm of the first heart field plus contiguous pharyngeal mesoderm that gives rise to second-heart-field-derived regions of the heart and branchiomeric muscles.
Material anatomical entity that forms the outermost boundary of an anatomical structure.
A bodily fluid that is located in the coelom.
Any gland that is part os the respiratory system.
A notochord that has persisted beyond the embryonic stage.
The zygomaticotemporal nerve or zygomaticotemporal branch (temporal branch) is derived from the maxillary branch of the trigeminal nerve (Cranial nerve V). It runs along the lateral wall of the orbit in a groove in the zygomatic bone, receives a branch of communication from the lacrimal, and passes through zygomaticotemporal foramen in the zygomatic bone to enter the temporal fossa. It ascends between the bone, and substance of the Temporalis muscle, pierces the temporal fascia about 2.5 cm. above the zygomatic arch, and is distributed to the skin of the side of the forehead, and communicates with the facial nerve and with the auriculotemporal branch of the mandibular nerve. As it pierces the temporal fascia, it gives off a slender twig, which runs between the two layers of the fascia to the lateral angle of the orbit.
ramus zygomaticotemporalis (Nervus zygomaticus)
zygomaticotemporal branch of zygomatic nerve
Wall of ventricle which is continuous with the wall of aorta.
Wall of ventricle which is continuous with the wall of pulmonary trunk.
Region of wall of right ventricle which is continuous with the lateral and septal walls of right ventricle.
myocardium of anterior wall of left ventricle
myocardium of anterior wall of right ventricle
A mucosa that is part of a lip region [Automatically generated definition].
vasculature of central nervous system plus retina
Wall of organ which has as its parts the endocardium, myocardium , epicardium, and the cardiac septum, surrounded by the pericardial sac proper and is continuous with the walls of the systemic and pulmonary arterial and venous trees.
Ovarian vein, each instance of which is a tributary of some inferior vena cava that drains the right pampiniform plexus of some broad ligament.
Ovarian vein, each instance of which is a tributary of some left renal vein that drains the left pampiniform plexus of some broad ligament.
A zone of skin that is part of the face.
An anatomical junction between two parts of the digestive tract.
Cartilage which is part of the axial skeleton.
Capillary that has pores in the endothelial cells (60-80 nm in diameter) that are spanned by a diaphragm of radially oriented fibrils and allow small molecules and limited amounts of protein to diffuse.
Non neural ectoderm that surrounds the presumptive neural plate and gives rise to neurogenic placodes.
Structures of the dermis, epidermis, glands and pigment cells recognizable on the external surfaces of the integument.
Not clear how this differs from parent class. See https://github.com/obophenotype/uberon/issues/1305
Dermal, epidermal, glandular and pigment structures of the external head integument.
Dermal, epidermal, glandular and pigment structures of the body integument.
Extracellular matrix that is mineralized.
Bone tissue mineralized with hydroxyapatite.
An anatomical surface that is part of a bone.
Left part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane.
Right part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane.
A collection of Purkinje fibers that receives signals from the right and left bundle branches and innervates the ventricular cardiac muscle. The Purkinje fiber network creates synchronized contractions of the heart ventricles.
Any of the smallest blood vessels where blood circulates within organ tissues. Microvessels include terminal arterioles, metarterioles, capillaries, and venules (but exclude lymphatic capillaries). Arterioles carry oxygenated blood to the capillaries, and blood flows out of the capillaries through venules into veins.
One or a subset of adjacent layers of the neocortex.
Collections of neurons in the central nervous system that have been demonstrated by histochemical fluorescence to contain the neurotransmitter norepinephrine (noradrenalin).
An anatomical system that eliminates waste products that arise as a result of metabolic activity.
A craniocervical region that is part of an embryo.
A portion of smooth muscle tissue that is part of the thoracic aorta.
A zone of skin that is above the clavicle zone in the pectoral girdle region.
A zone of skin that is part of the external genitalia.
A muscle tissue that is associated with soft internal organs (viscera).
It is quite common to refer to visceral muscles as smooth muscles, by analogy with vertebrates; however, most visceral muscles in arthropods are actually striated.
A striated muscle tissue that is associated with soft internal organs (viscera).
A venule that is part of a lung and drains oxygenated blood from pulmonary capillaries. A pulmonary venule merges into a pulmonary vein branch that runs in the pulmonary interlobular septa.
A parasympathetic ganglion that is located within the airway walls of the lower respiratory tract. This ganglion is responsible for controlling the constriction of the airway by stimulating smooth muscle contraction in the lower respiratory tract to regulate airflow.