format-version: 1.2 date: 11:03:2021 18:56 auto-generated-by: https://github.com/pharmacome/conso/blob/master/src/conso/export/obo.py ontology: conso [Typedef] id: bfo:0000050 name: part of comment: Inverse of has_part [Typedef] id: CONSO:author name: term has author comment: A term has an author with the given ORCID identifier is_transitive: false [Typedef] id: CONSO:has_reference_protein name: protein isoform term has reference protein comment: A link between a protein isoform and its reference protein is_transitive: false [Typedef] id: ro:0000087 name: has role [Typedef] id: CONSO:inhibitor name: inhibitor namespace: external comment: A substance that diminishes the rate of a chemical reaction. xref: chebi:35222 is_transitive: false [Typedef] id: CONSO:agonist name: agonist namespace: external comment: Substance which binds to cell receptors normally responding to naturally occurring substances and which produces a response of its own. xref: chebi:48705 is_transitive: false [Typedef] id: CONSO:has_antibody_target name: Antibody has target protein comment: Links an antibody to its target. is_transitive: false [Term] id: CONSO:CONSO00001 name: microtubule-binding region namespace: domain def: "The motif in the MAPT protein where microtubule binding repeats" [pubmed:18500754, pubmed:2516729] xref: interpro:IPR001084 relationship: bfo:0000050 CONSO:CONSO00188 relationship: CONSO:author orcid:0000-0003-4423-4370 synonym: "MTBR" EXACT [] [Term] id: CONSO:CONSO00002 name: tubulin-binding repeat 1 namespace: domain def: "position 569_591 of canonical isoform of MAPT protein" [pubmed:18500754] relationship: bfo:0000050 CONSO:CONSO00001 relationship: CONSO:author orcid:0000-0001-9661-5277 property_value: bel "p(HGNC:MAPT, frag(569_591))" xsd:string synonym: "MTBR R1" EXACT [] synonym: "R1" EXACT [] [Term] id: CONSO:CONSO00003 name: tubulin-binding repeat 2 namespace: domain def: "position 592_621 of canonical isoform of MAPT protein" [pubmed:18500754] relationship: bfo:0000050 CONSO:CONSO00001 relationship: CONSO:author orcid:0000-0001-9661-5277 property_value: bel "p(HGNC:MAPT, frag(592_621))" xsd:string synonym: "MTBR R2" EXACT [] synonym: "R2" EXACT [] [Term] id: CONSO:CONSO00004 name: tubulin-binding repeat 3 namespace: domain def: "position 623_653 of canonical isoform of MAPT protein" [pubmed:18500754] relationship: bfo:0000050 CONSO:CONSO00001 relationship: CONSO:author orcid:0000-0001-9661-5277 property_value: bel "p(HGNC:MAPT, frag(623_653))" xsd:string synonym: "MTBR R3" EXACT [] synonym: "R3" EXACT [] [Term] id: CONSO:CONSO00005 name: tubulin-binding repeat 4 namespace: domain def: "position 654_685 of canonical isoform of MAPT protein" [pubmed:18500754] relationship: bfo:0000050 CONSO:CONSO00001 relationship: CONSO:author orcid:0000-0001-9661-5277 property_value: bel "p(HGNC:MAPT, frag(654_685))" xsd:string synonym: "MTBR R4" EXACT [] synonym: "R4" EXACT [] [Term] id: CONSO:CONSO00006 name: Tau aggregates namespace: cellular_component def: "Tau (MAPT) in its aggregated form (as Paired Helical Filaments (PHFs) or Straight Filaments (SF)) contains 5–9 moles of phosphate/ mole of the protein, defining it as hyper phosphorylated" [pmc:PMC2633703] is_a: CONSO:CONSO00178 ! protein aggregates relationship: CONSO:author orcid:0000-0003-4423-4370 [Term] id: CONSO:CONSO00007 name: hyperphosphorylation namespace: post_translational_modification def: "An excessive phosphorylation (see GO:0006468)" [pubmed:22710920] relationship: CONSO:author orcid:0000-0003-4423-4370 [Term] id: CONSO:CONSO00008 name: GAL80TS namespace: exposure def: "temperature-sensitive allele of GAL80 (tub-GAL80TS)" [pmc:PMC3073608] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00009 name: Tau oligomers namespace: cellular_component def: "CAST is known to prevent oligomerization of Tau (Rao et al., 2014) and α-synuclein (Diepenbroek et al. 2014) and inhibit reactive gliosis (Rao et al., 2008)" [pmc:PMC4828294] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00010 name: LY293002 namespace: chemical def: "a typo appearing in pubmed:23950935 for the specific PI3-kinase inhibitor that is actually named LY294002" [pubmed:23950935] xref: cas:154447-36-6 xref: chebi:65329 xref: drugbank:DB02656 xref: inchi:InChI=1S/C19H17NO3/c21-17-13-18\(20-9-11-22-12-10-20\)23-19-15\(7-4-8-16\(17\)19\)14-5-2-1-3-6-14/h1-8\,13H\,9-12H2 xref: pubchem.compound:3973 xref: smiles:C1COCCN1C2=CC\(=O\)C3=C\(O2\)C\(=CC=C3\)C4=CC=CC=C4 relationship: CONSO:inhibitor FPLX:PI3K relationship: CONSO:author orcid:0000-0002-3034-9970 synonym: "154447-36-6" EXACT [pubchem.compound:3973] synonym: "15447-36-6" EXACT [pubchem.compound:3973] synonym: "1yi3" EXACT [pubchem.compound:3973] synonym: "2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one" EXACT [pubchem.compound:3973] synonym: "2-(4-morpholino)-8-phenyl-4H-1-benzopyran-4-one" EXACT [pubchem.compound:3973] synonym: "2-(morpholin-4-yl)-8-phenyl-4H-chromen-4-one" EXACT [pubchem.compound:3973] synonym: "2-(morpholin-4-yl)-8-phenylchromen-4-one" EXACT [pubchem.compound:3973] synonym: "2-MORPHOLIN-4-YL-7-PHENYL-4H-CHROMEN-4-ONE" EXACT [pubchem.compound:3973] synonym: "2-Morpholin-4-yl-8-phenyl-chromen-4-one" EXACT [pubchem.compound:3973] synonym: "2-Morpholino-8-phenyl-4-oxo-4H-1-benzopyran" EXACT [pubchem.compound:3973] synonym: "2-Morpholino-8-phenylchromone" EXACT [pubchem.compound:3973] synonym: "2-morpholin-4-yl-8-phenyl-4H-chromen-4-one" EXACT [pubchem.compound:3973] synonym: "2-morpholin-4-yl-8-phenylchromen-4-one" EXACT [pubchem.compound:3973] synonym: "2-morpholino-8-phenyl-4H-chromen-4-one" EXACT [pubchem.compound:3973] synonym: "2-morpholino-8-phenyl-chromen-4-one" EXACT [pubchem.compound:3973] synonym: "31M2U1DVID" EXACT [pubchem.compound:3973] synonym: "4CA-0787" EXACT [pubchem.compound:3973] synonym: "4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl" EXACT [pubchem.compound:3973] synonym: "4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-" EXACT [pubchem.compound:3973] synonym: "4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl- (9CI)" EXACT [pubchem.compound:3973] synonym: "4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-(9CI)" EXACT [pubchem.compound:3973] synonym: "4H-1-Benzopyran-4-one,2-(4-morpholinyl)-8-phenyl-" EXACT [pubchem.compound:3973] synonym: "4azt" EXACT [pubchem.compound:3973] synonym: "8-Phenyl-2-(morpholin-4-yl)-chromen-4-one" EXACT [pubchem.compound:3973] synonym: "AB0033714" EXACT [pubchem.compound:3973] synonym: "AC-30295" EXACT [pubchem.compound:3973] synonym: "AC1L1H4N" EXACT [pubchem.compound:3973] synonym: "AC1Q6CLU" EXACT [pubchem.compound:3973] synonym: "AK162301" EXACT [pubchem.compound:3973] synonym: "AKOS017344742" EXACT [pubchem.compound:3973] synonym: "AN-1305" EXACT [pubchem.compound:3973] synonym: "API0015880" EXACT [pubchem.compound:3973] synonym: "AS-16252" EXACT [pubchem.compound:3973] synonym: "BC660045" EXACT [pubchem.compound:3973] synonym: "BCBcMAP01_000117" EXACT [pubchem.compound:3973] synonym: "BCP00195" EXACT [pubchem.compound:3973] synonym: "BCP9000880" EXACT [pubchem.compound:3973] synonym: "BCPP000177" EXACT [pubchem.compound:3973] synonym: "BDBM12915" EXACT [pubchem.compound:3973] synonym: "BIL2940" EXACT [pubchem.compound:3973] synonym: "BMK1-D5" EXACT [pubchem.compound:3973] synonym: "BRD-K27305650-001-05-9" EXACT [pubchem.compound:3973] synonym: "BSPBio_001223" EXACT [pubchem.compound:3973] synonym: "Bio1_000332" EXACT [pubchem.compound:3973] synonym: "Bio1_000821" EXACT [pubchem.compound:3973] synonym: "Bio1_001310" EXACT [pubchem.compound:3973] synonym: "Bio2_000442" EXACT [pubchem.compound:3973] synonym: "Bio2_000922" EXACT [pubchem.compound:3973] synonym: "BiomolKI2_000037" EXACT [pubchem.compound:3973] synonym: "BiomolKI_000029" EXACT [pubchem.compound:3973] synonym: "C15195" EXACT [pubchem.compound:3973] synonym: "CBiol_002046" EXACT [pubchem.compound:3973] synonym: "CCG-100633" EXACT [pubchem.compound:3973] synonym: "CHEBI:65329" EXACT [pubchem.compound:3973] synonym: "CHEMBL98350" EXACT [pubchem.compound:3973] synonym: "CS-0150" EXACT [pubchem.compound:3973] synonym: "CTK0H1979" EXACT [pubchem.compound:3973] synonym: "CZQHHVNHHHRRDU-UHFFFAOYSA-N" EXACT [pubchem.compound:3973] synonym: "D09SFV" EXACT [pubchem.compound:3973] synonym: "D0X7NA" EXACT [pubchem.compound:3973] synonym: "DB02656" EXACT [pubchem.compound:3973] synonym: "DTXSID6042650" EXACT [pubchem.compound:3973] synonym: "EC-000.2341" EXACT [pubchem.compound:3973] synonym: "EX-A073" EXACT [pubchem.compound:3973] synonym: "FT-0660382" EXACT [pubchem.compound:3973] synonym: "GTPL6004" EXACT [pubchem.compound:3973] synonym: "H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl- (9CI)" EXACT [pubchem.compound:3973] synonym: "H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-(9CI)" EXACT [pubchem.compound:3973] synonym: "HMS1362M05" EXACT [pubchem.compound:3973] synonym: "HMS1792M05" EXACT [pubchem.compound:3973] synonym: "HMS1990M05" EXACT [pubchem.compound:3973] synonym: "HMS3229G17" EXACT [pubchem.compound:3973] synonym: "HMS3403M05" EXACT [pubchem.compound:3973] synonym: "HMS3649E04" EXACT [pubchem.compound:3973] synonym: "HMS3654M21" EXACT [pubchem.compound:3973] synonym: "HSCI1_000206" EXACT [pubchem.compound:3973] synonym: "HY-10108" EXACT [pubchem.compound:3973] synonym: "IDI1_002197" EXACT [pubchem.compound:3973] synonym: "IN1266" EXACT [pubchem.compound:3973] synonym: "IN1268" EXACT [pubchem.compound:3973] synonym: "InSolution™ LY 294002" EXACT [pubchem.compound:3973] synonym: "J-510126" EXACT [pubchem.compound:3973] synonym: "K00235" EXACT [pubchem.compound:3973] synonym: "KB-19284" EXACT [pubchem.compound:3973] synonym: "KB-231805" EXACT [pubchem.compound:3973] synonym: "KBio2_000563" EXACT [pubchem.compound:3973] synonym: "KBio2_003131" EXACT [pubchem.compound:3973] synonym: "KBio2_005699" EXACT [pubchem.compound:3973] synonym: "KBio3_001005" EXACT [pubchem.compound:3973] synonym: "KBio3_001006" EXACT [pubchem.compound:3973] synonym: "KBioGR_000563" EXACT [pubchem.compound:3973] synonym: "KBioSS_000563" EXACT [pubchem.compound:3973] synonym: "KS-00000XP3" EXACT [pubchem.compound:3973] synonym: "Kinome_3543" EXACT [pubchem.compound:3973] synonym: "LS-39828" EXACT [pubchem.compound:3973] synonym: "LY 294002" EXACT [pubchem.compound:3973] synonym: "LY 294002, LY-294002, 154447-36-6" EXACT [pubchem.compound:3973] synonym: "LY 294002; 2-(4-Morpholino)-8-phenyl-4H-1-benzopyran-4-one" EXACT [pubchem.compound:3973] synonym: "LY-294,002" EXACT [pubchem.compound:3973] synonym: "LY-294,002 hydrochloride, solid, >=98% (HPLC)" EXACT [pubchem.compound:3973] synonym: "LY-294002" EXACT [pubchem.compound:3973] synonym: "LY-924002" EXACT [pubchem.compound:3973] synonym: "LY2" EXACT [pubchem.compound:3973] synonym: "LY294002" EXACT [pubchem.compound:3973] synonym: "Lopac-L-9908" EXACT [pubchem.compound:3973] synonym: "Lopac0_000710" EXACT [pubchem.compound:3973] synonym: "Lys 294002" EXACT [pubchem.compound:3973] synonym: "M2410" EXACT [pubchem.compound:3973] synonym: "MLS006010131" EXACT [pubchem.compound:3973] synonym: "MolPort-003-983-779" EXACT [pubchem.compound:3973] synonym: "NCGC00015622-01" EXACT [pubchem.compound:3973] synonym: "NCGC00015622-02" EXACT [pubchem.compound:3973] synonym: "NCGC00015622-03" EXACT [pubchem.compound:3973] synonym: "NCGC00015622-04" EXACT [pubchem.compound:3973] synonym: "NCGC00015622-05" EXACT [pubchem.compound:3973] synonym: "NCGC00015622-06" EXACT [pubchem.compound:3973] synonym: "NCGC00015622-07" EXACT [pubchem.compound:3973] synonym: "NCGC00025020-01" EXACT [pubchem.compound:3973] synonym: "NCGC00025020-02" EXACT [pubchem.compound:3973] synonym: "NCGC00025020-03" EXACT [pubchem.compound:3973] synonym: "NCGC00025020-04" EXACT [pubchem.compound:3973] synonym: "NCGC00179253-01" EXACT [pubchem.compound:3973] synonym: "NCI60_034712" EXACT [pubchem.compound:3973] synonym: "NSC 697286" EXACT [pubchem.compound:3973] synonym: "NSC-697286" EXACT [pubchem.compound:3973] synonym: "NSC697286" EXACT [pubchem.compound:3973] synonym: "PubChem16766" EXACT [pubchem.compound:3973] synonym: "QC-7260" EXACT [pubchem.compound:3973] synonym: "RS0074" EXACT [pubchem.compound:3973] synonym: "RT-013609" EXACT [pubchem.compound:3973] synonym: "S-7706" EXACT [pubchem.compound:3973] synonym: "SB10965" EXACT [pubchem.compound:3973] synonym: "SC-85850" EXACT [pubchem.compound:3973] synonym: "SCHEMBL94377" EXACT [pubchem.compound:3973] synonym: "SF 1101" EXACT [pubchem.compound:3973] synonym: "SF-1101" EXACT [pubchem.compound:3973] synonym: "SMR002530642" EXACT [pubchem.compound:3973] synonym: "SR-01000076245-7" EXACT [pubchem.compound:3973] synonym: "ST24040926" EXACT [pubchem.compound:3973] synonym: "SW217688-2" EXACT [pubchem.compound:3973] synonym: "SYN1108" EXACT [pubchem.compound:3973] synonym: "Tocris-1130" EXACT [pubchem.compound:3973] synonym: "UNII-31M2U1DVID" EXACT [pubchem.compound:3973] synonym: "X7411" EXACT [pubchem.compound:3973] synonym: "ZINC6014" EXACT [pubchem.compound:3973] synonym: "ZX-AFC000490" EXACT [pubchem.compound:3973] synonym: "cc-58" EXACT [pubchem.compound:3973] synonym: "s1105" EXACT [pubchem.compound:3973] [Term] id: CONSO:CONSO00011 name: LPLI namespace: exposure def: "Low-power laser irradiation (LPLI) is a non-damage physical therapy" [pubmed:20333643] relationship: CONSO:author orcid:0000-0002-3034-9970 synonym: "Low-power laser irradiation" EXACT [] [Term] id: CONSO:CONSO00012 name: Chronic cerebral hypoperfusion namespace: pathology def: "Chronic cerebral hypoperfusion (CCH) is one of the causes of vascular dementia (VaD) and is also an etiological factor for Alzheimer's disease (AD)" [pubmed:24575038] relationship: CONSO:author orcid:0000-0002-3034-9970 synonym: "CCH" EXACT [] [Term] id: CONSO:CONSO00013 name: Mori Fructus ethanol extract namespace: chemical_mixture def: "ethanol extracted from Mori Fructus, a well-known traditional herbal medicine, food, and dietary supplement" [pubmed:26068423] relationship: CONSO:author orcid:0000-0002-3034-9970 synonym: "ME" EXACT [] [Term] id: CONSO:CONSO00014 name: tunneling nanotubes namespace: cellular_component def: "filamentous-actin-containing membranous structures that bridge and connect cells" [pubmed:27809932] relationship: CONSO:author orcid:0000-0002-3034-9970 synonym: "TNT" EXACT [] synonym: "membrane nanotube" EXACT [] [Term] id: CONSO:CONSO00015 name: amyloidogenesis namespace: biological_process def: "production of amyloid" [pubmed:24653673] relationship: CONSO:author orcid:0000-0002-3034-9970 [Term] id: CONSO:CONSO00016 name: alpha-synuclein aggregates namespace: cellular_component def: "alpha-synuclein (SNCA) aggregate in fibrillar or oligomeric forms, usually found in Lewy bodies" [pubmed:23254192] is_a: CONSO:CONSO00178 ! protein aggregates relationship: CONSO:author orcid:0000-0003-4423-4370 [Term] id: CONSO:CONSO00017 name: huntingtin aggregates namespace: cellular_component def: "huntingtin (HTT) protein fragments aggregations" [pubmed:12747895] is_a: CONSO:CONSO00178 ! protein aggregates relationship: CONSO:author orcid:0000-0003-4423-4370 [Term] id: CONSO:CONSO00018 name: amyloid-beta aggregates namespace: cellular_component def: "aggregation of amyloid-beta fragments of the APP protein" [pubmed:23484434] is_a: CONSO:CONSO00178 ! protein aggregates relationship: CONSO:author orcid:0000-0003-4423-4370 [Term] id: CONSO:CONSO00019 name: SEN-1269 namespace: chemical def: "A tau aggregation inhibitor" [pubmed:23484434] xref: chembl:CHEMBL2386874 xref: inchi:InChI=1S/C18H18N4O2/c1-22\(2\)14-6-4-8-16\(10-14\)24-17-11-19-18\(20-12-17\)21-13-5-3-7-15\(23\)9-13/h3-12\,23H\,1-2H3\,\(H\,19\,20\,21\) xref: pubchem.compound:46835756 xref: smiles:CN\(C\)C1=CC\(=CC=C1\)OC2=CN=C\(N=C2\)NC3=CC\(=CC=C3\)O relationship: ro:0000087 CONSO:CONSO00321 relationship: CONSO:author orcid:0000-0003-4423-4370 synonym: "3-((5-(3-(Dimethylamino)phenoxy)pyrimidin-2-yl)amino)phenol" EXACT [pubchem.compound:46835756] synonym: "3-(5-(3-(dimethylamino)phenoxy)pyrimidin-2-ylamino)phenol" EXACT [pubchem.compound:46835756] synonym: "3-({5-[3-(dimethylamino)phenoxy]pyrimidin-2-yl}amino)phenol" EXACT [pubchem.compound:46835756] synonym: "3-[[5-[3-(dimethylamino)phenoxy]-2-pyrimidinyl]amino]phenol" EXACT [pubchem.compound:46835756] synonym: "4350AF" EXACT [pubchem.compound:46835756] synonym: "956128-01-1" EXACT [pubchem.compound:46835756] synonym: "A11161" EXACT [pubchem.compound:46835756] synonym: "AKOS015850742" EXACT [pubchem.compound:46835756] synonym: "CHEMBL2386874" EXACT [pubchem.compound:46835756] synonym: "CTK5H7888" EXACT [pubchem.compound:46835756] synonym: "DB-080315" EXACT [pubchem.compound:46835756] synonym: "DTXSID40676566" EXACT [pubchem.compound:46835756] synonym: "FT-0682533" EXACT [pubchem.compound:46835756] synonym: "I06-2365" EXACT [pubchem.compound:46835756] synonym: "MFPAAKZZUIRMKR-UHFFFAOYSA-N" EXACT [pubchem.compound:46835756] synonym: "MolPort-009-685-119" EXACT [pubchem.compound:46835756] synonym: "NCGC00387448-01" EXACT [pubchem.compound:46835756] synonym: "SCHEMBL3602388" EXACT [pubchem.compound:46835756] synonym: "SEN 1269" EXACT [pubchem.compound:46835756] synonym: "TC-064564" EXACT [pubchem.compound:46835756] synonym: "ZINC49582255" EXACT [pubchem.compound:46835756] [Term] id: CONSO:CONSO00020 name: MLS000034832 namespace: chemical def: "A tau aggregation inhibitor" [pubmed:23484434] xref: chembl:CHEMBL461431 xref: inchi:InChI=1S/C15H13N3O3S/c1-2-21-15\(20\)12-10-8-22-13\(16\)11\(10\)14\(19\)18\(17-12\)9-6-4-3-5-7-9/h3-8H\,2\,16H2\,1H3 xref: pubchem.compound:647821 xref: smiles:CCOC\(=O\)C1=NN\(C\(=O\)C2=C\(SC=C21\)N\)C3=CC=CC=C3 relationship: ro:0000087 CONSO:CONSO00321 relationship: CONSO:author orcid:0000-0003-4423-4370 synonym: "123542-47-2" EXACT [pubchem.compound:647821] synonym: "3-Phenyl-4-oxo-5-amino-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylic acid ethyl ester" EXACT [pubchem.compound:647821] synonym: "5-Amino-4-oxo-3-phenyl-3,4-dihydro-thieno[3,4-d]pyridazine-1-carboxylic acid eth" EXACT [pubchem.compound:647821] synonym: "5-Amino-4-oxo-3-phenyl-3,4-dihydro-thieno[3,4-d]pyridazine-1-carboxylic acid ethyl ester" EXACT [pubchem.compound:647821] synonym: "AC1LDGR2" EXACT [pubchem.compound:647821] synonym: "AC1Q34EJ" EXACT [pubchem.compound:647821] synonym: "AKOS000601368" EXACT [pubchem.compound:647821] synonym: "BAS 06046551" EXACT [pubchem.compound:647821] synonym: "BDBM50253793" EXACT [pubchem.compound:647821] synonym: "CCG-115473" EXACT [pubchem.compound:647821] synonym: "CHEMBL461431" EXACT [pubchem.compound:647821] synonym: "F2135-0238" EXACT [pubchem.compound:647821] synonym: "HLVGVGCIJRBRQW-UHFFFAOYSA-N" EXACT [pubchem.compound:647821] synonym: "HMS1616C21" EXACT [pubchem.compound:647821] synonym: "HMS2339G13" EXACT [pubchem.compound:647821] synonym: "L-4233" EXACT [pubchem.compound:647821] synonym: "MCULE-6208802152" EXACT [pubchem.compound:647821] synonym: "MLS000034832" EXACT [pubchem.compound:647821] synonym: "MLS002539346" EXACT [pubchem.compound:647821] synonym: "MolPort-001-835-700" EXACT [pubchem.compound:647821] synonym: "NCGC00031883-02" EXACT [pubchem.compound:647821] synonym: "SCHEMBL7885074" EXACT [pubchem.compound:647821] synonym: "SMR000013604" EXACT [pubchem.compound:647821] synonym: "ZINC563211" EXACT [pubchem.compound:647821] synonym: "ethyl 5-amino-4-oxo-3-phenyl-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate" EXACT [pubchem.compound:647821] synonym: "ethyl 5-amino-4-oxo-3-phenyl-3H,4H-thieno[3,4-d]pyridazine-1-carboxylate" EXACT [pubchem.compound:647821] synonym: "ethyl 5-amino-4-oxo-3-phenylthieno[3,4-d]pyridazine-1-carboxylate" EXACT [pubchem.compound:647821] [Term] id: CONSO:CONSO00021 name: caprospinol namespace: chemical def: "A tau aggregation inhibitor" [pubmed:23484434] xref: drugbank:DB05263 xref: inchi:InChI=1S/C33H52O4/c1-6-7-8-9-29\(34\)36-24-13-15-31\(4\)23\(18-24\)10-11-25-26\(31\)14-16-32\(5\)27\(25\)19-28-30\(32\)22\(3\)33\(37-28\)17-12-21\(2\)20-35-33/h10\,21-22\,24-28\,30H\,6-9\,11-20H2\,1-5H3/t21-\,22+\,24+\,25-\,26+\,27+\,28+\,30+\,31+\,32+\,33-/m1/s1 xref: pubchem.compound:16394575 xref: smiles:CCCCCC\(=O\)O\[C@H\]1CC\[C@\]2\(C\)\[C@H\]3CC\[C@@\]4\(C\)\[C@@H\]\(C\[C@@H\]5O\[C@\]6\(CC\[C@@H\]\(C\)CO6\)\[C@@H\]\(C\)\[C@H\]45\)\[C@@H\]3CC=C2C1 relationship: ro:0000087 CONSO:CONSO00321 relationship: CONSO:author orcid:0000-0003-4423-4370 synonym: "((20S,22R,25R)-Spirosta-5-ene-3beta-ol)hexanoate" EXACT [pubchem.compound:16394575] synonym: "(22R,25R)-20alpha-Spirost-5-en-3beta-yl hexanoate" EXACT [pubchem.compound:16394575] synonym: "(3beta,8xi,9xi,14xi,16xi,17xi,20R,22xi,25R)-Spirost-5-en-3-yl hexanoa" EXACT [pubchem.compound:16394575] synonym: "4952-56-1" EXACT [pubchem.compound:16394575] synonym: "9BU4T267E4" EXACT [pubchem.compound:16394575] synonym: "AKOS015955746" EXACT [pubchem.compound:16394575] synonym: "CAPROSPINOL" EXACT [pubchem.compound:16394575] synonym: "DB05263" EXACT [pubchem.compound:16394575] synonym: "Diosgenin caproate" EXACT [pubchem.compound:16394575] synonym: "Diosgenin, hexanoate" EXACT [pubchem.compound:16394575] synonym: "J2.343.184J" EXACT [pubchem.compound:16394575] synonym: "MCULE-6852340934" EXACT [pubchem.compound:16394575] synonym: "MolPort-002-507-344" EXACT [pubchem.compound:16394575] synonym: "SP-223" EXACT [pubchem.compound:16394575] synonym: "SP-233" EXACT [pubchem.compound:16394575] synonym: "Spirost-5-en-3-ol, 3-hexanoate, (3beta,25R)-" EXACT [pubchem.compound:16394575] synonym: "UNII-9BU4T267E4" EXACT [pubchem.compound:16394575] synonym: "ZINC97971833" EXACT [pubchem.compound:16394575] [Term] id: CONSO:CONSO00022 name: amyloid-beta oligomers namespace: cellular_component def: "Small aggregates of amyloid-beta" [pubmed:24918635, pubmed:29196815] relationship: CONSO:author orcid:0000-0003-4423-4370 [Term] id: CONSO:CONSO00023 name: amyloid-beta 42 oligomers namespace: cellular_component def: "Amyloid-beta oligomers composed specifically of amyloid-beta 42" [pubmed:24918635] relationship: CONSO:author orcid:0000-0003-4423-4370 [Term] id: CONSO:CONSO00024 name: APP C-terminally truncated carboxyl-terminal fragments namespace: protein_fragment def: "C-terminally truncated carboxyl-terminal fragments (CTFs) of APP" [pubmed:15491160] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00025 name: A2B5 antigen namespace: epitope def: "A2B5 antigen is a cell surface ganglioside epitope expressed on developing thymic epithelial cells, oligodendrocyte progenitors, and neuroendocrine cells." [pubmed:1497614] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00026 name: neutral sphingomyelinase namespace: enzyme_class def: "Sphingomyelin phosphodiesterase (EC 3.1.4.12, also known as neutral sphingomyelinase, sphingomyelinase, or SMase) is a hydrolase enzyme that is involved in sphingolipid metabolism reactions." [pubmed:19519303] xref: ec-code:3.1.4.12 relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00027 name: Neurodegeneration namespace: pathology def: "Neurodegeneration is the progressive loss of structure or function of neurons, including death of neurons. Many neurodegenerative diseases – including amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease, and Huntington's disease – occur as a result of neurodegenerative processes." [pubmed:20202123, pubmed:12387894] xref: hp:0002180 relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00028 name: amyloid-beta derived diffusible ligands namespace: cellular_component def: "soluble oligomeric forms of the amyloid beta peptide known as amyloid-derived diffusible ligands (ADDLs) are the toxic species responsible for neurodegeneration associated with Alzheimer's disease." [pubmed:19188609] relationship: CONSO:author orcid:0000-0002-0303-8616 synonym: "ADDL" EXACT [pubmed:16712494] [Term] id: CONSO:CONSO00029 name: Hyperamylinemia namespace: pathology def: "increased secretion of the pancreatic hormone amylin" [pubmed:23794448] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00030 name: APOE e4 namespace: genetic_variant def: "APOE e4 is a variant of APOE, it's APOE-ε4 (arg112, arg158)." [pubmed:22701550] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00031 name: N-AcGIP namespace: chemical def: "N-AcGIP is a rat hormone that is an agonist of GIP" [pubmed:18234983] relationship: CONSO:agonist HGNC:HGNC:4270 relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00032 name: Pro3-GIP namespace: chemical def: "Pro3-GIP is a rat hormone that is an agonist of GIP" [pubmed:18234983] xref: inchi:InChI=1S/C226H343N61O64S/c1-21-115\(12\)181\(285-216\(341\)165\(109-289\)279-201\(326\)151\(92-126-63-67-131\(293\)68-64-126\)266-210\(335\)163\(102-179\(309\)310\)276-215\(340\)164\(108-288\)280-221\(346\)183\(117\(14\)23-3\)284-214\(339\)153\(91-124-48-28-25-29-49-124\)277-222\(347\)184\(121\(18\)290\)281-175\(302\)107-247-217\(342\)166-60-45-84-287\(166\)224\(349\)120\(17\)251-188\(313\)134\(232\)89-125-61-65-130\(292\)66-62-125\)219\(344\)250-119\(16\)187\(312\)254-146\(77-85-352-20\)197\(322\)274-160\(99-176\(303\)304\)208\(333\)258-141\(58-38-43-82-231\)198\(323\)283-182\(116\(13\)22-2\)220\(345\)261-142\(59-44-83-243-226\(240\)241\)191\(316\)259-144\(70-74-168\(234\)295\)195\(320\)260-145\(71-75-169\(235\)296\)196\(321\)273-161\(100-177\(305\)306\)209\(334\)267-152\(90-123-46-26-24-27-47-123\)213\(338\)282-180\(114\(10\)11\)218\(343\)278-159\(98-173\(239\)300\)207\(332\)268-155\(94-128-104-245-136-53-33-31-51-133\(128\)136\)203\(328\)264-149\(87-112\(6\)7\)200\(325\)263-148\(86-111\(4\)5\)199\(324\)249-118\(15\)186\(311\)253-143\(69-73-167\(233\)294\)194\(319\)255-137\(54-34-39-78-227\)189\(314\)246-106-174\(301\)252-138\(55-35-40-79-228\)190\(315\)256-139\(56-36-41-80-229\)193\(318\)271-157\(96-171\(237\)298\)206\(331\)275-162\(101-178\(307\)308\)211\(336\)269-154\(93-127-103-244-135-52-32-30-50-132\(127\)135\)202\(327\)257-140\(57-37-42-81-230\)192\(317\)270-156\(95-129-105-242-110-248-129\)204\(329\)272-158\(97-172\(238\)299\)205\(330\)265-150\(88-113\(8\)9\)212\(337\)286-185\(122\(19\)291\)223\(348\)262-147\(225\(350\)351\)72-76-170\(236\)297/h24-33\,46-53\,61-68\,103-105\,110-122\,134\,137-166\,180-185\,244-245\,288-293H\,21-23\,34-45\,54-60\,69-102\,106-109\,227-232H2\,1-20H3\,\(H2\,233\,294\)\(H2\,234\,295\)\(H2\,235\,296\)\(H2\,236\,297\)\(H2\,237\,298\)\(H2\,238\,299\)\(H2\,239\,300\)\(H\,242\,248\)\(H\,246\,314\)\(H\,247\,342\)\(H\,249\,324\)\(H\,250\,344\)\(H\,251\,313\)\(H\,252\,301\)\(H\,253\,311\)\(H\,254\,312\)\(H\,255\,319\)\(H\,256\,315\)\(H\,257\,327\)\(H\,258\,333\)\(H\,259\,316\)\(H\,260\,320\)\(H\,261\,345\)\(H\,262\,348\)\(H\,263\,325\)\(H\,264\,328\)\(H\,265\,330\)\(H\,266\,335\)\(H\,267\,334\)\(H\,268\,332\)\(H\,269\,336\)\(H\,270\,317\)\(H\,271\,318\)\(H\,272\,329\)\(H\,273\,321\)\(H\,274\,322\)\(H\,275\,331\)\(H\,276\,340\)\(H\,277\,347\)\(H\,278\,343\)\(H\,279\,326\)\(H\,280\,346\)\(H\,281\,302\)\(H\,282\,338\)\(H\,283\,323\)\(H\,284\,339\)\(H\,285\,341\)\(H\,286\,337\)\(H\,303\,304\)\(H\,305\,306\)\(H\,307\,308\)\(H\,309\,310\)\(H\,350\,351\)\(H4\,240\,241\,243\) xref: pubchem.compound:131954578 xref: smiles:CCC\(C\)C\(C\(=O\)NC\(CCCNC\(=N\)N\)C\(=O\)NC\(CCC\(=O\)N\)C\(=O\)NC\(CCC\(=O\)N\)C\(=O\)NC\(CC\(=O\)O\)C\(=O\)NC\(CC1=CC=CC=C1\)C\(=O\)NC\(C\(C\)C\)C\(=O\)NC\(CC\(=O\)N\)C\(=O\)NC\(CC2=CNC3=CC=CC=C32\)C\(=O\)NC\(CC\(C\)C\)C\(=O\)NC\(CC\(C\)C\)C\(=O\)NC\(C\)C\(=O\)NC\(CCC\(=O\)N\)C\(=O\)NC\(CCCCN\)C\(=O\)NCC\(=O\)NC\(CCCCN\)C\(=O\)NC\(CCCCN\)C\(=O\)NC\(CC\(=O\)N\)C\(=O\)NC\(CC\(=O\)O\)C\(=O\)NC\(CC4=CNC5=CC=CC=C54\)C\(=O\)NC\(CCCCN\)C\(=O\)NC\(CC6=CNC=N6\)C\(=O\)NC\(CC\(=O\)N\)C\(=O\)NC\(CC\(C\)C\)C\(=O\)NC\(C\(C\)O\)C\(=O\)NC\(CCC\(=O\)N\)C\(=O\)O\)NC\(=O\)C\(CCCCN\)NC\(=O\)C\(CC\(=O\)O\)NC\(=O\)C\(CCSC\)NC\(=O\)C\(C\)NC\(=O\)C\(C\(C\)CC\)NC\(=O\)C\(CO\)NC\(=O\)C\(CC7=CC=C\(C=C7\)O\)NC\(=O\)C\(CC\(=O\)O\)NC\(=O\)C\(CO\)NC\(=O\)C\(C\(C\)CC\)NC\(=O\)C\(CC8=CC=CC=C8\)NC\(=O\)C\(C\(C\)O\)NC\(=O\)CNC\(=O\)C9CCCN9C\(=O\)C\(C\)NC\(=O\)C\(CC1=CC=C\(C=C1\)O\)N relationship: CONSO:agonist HGNC:HGNC:4270 relationship: CONSO:author orcid:0000-0002-0303-8616 synonym: "AKOS034831571" EXACT [pubchem.compound:131954578] synonym: "[Pro3]-GIP (Rat)" EXACT [pubchem.compound:131954578] [Term] id: CONSO:CONSO00033 name: PI3K-Akt signaling pathway namespace: pathway def: "PI3K-Akt signaling pathway is an intracellular signaling pathway important in regulating the cell cycle.It is described in KEGG." [pubmed:22013558] xref: kegg.pathway:hsa04151 relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00035 name: Argyrophilic Grain Disease namespace: pathology def: "Argyrophilic grain disease (AGD) is an under-recognized, distinct, highly frequent sporadic tauopathy, with a prevalence reaching 31.3% in centenarians." [pubmed:15658002] relationship: CONSO:author orcid:0000-0002-0303-8616 synonym: "AGD" EXACT [] [Term] id: CONSO:CONSO00036 name: granulovacuolar degeneration namespace: pathology def: "Granulovacuolar degeneration (GVD) is one of the pathological hallmarks of Alzheimer's disease (AD), and it is defined as electron-dense granules within double membrane-bound cytoplasmic vacuoles." [pubmed:17455299] xref: hp:0002528 relationship: CONSO:author orcid:0000-0002-0303-8616 synonym: "GVD" EXACT [] [Term] id: CONSO:CONSO00037 name: mitochondrial dysfunction namespace: pathology def: "mitochondria function disorder" [pubmed:19885299] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00038 name: amyloid-beta fibrils namespace: cellular_component def: "Insoluble fibrous protein aggregates exhibiting beta sheet structure." [pubmed:19158505] relationship: CONSO:author orcid:0000-0003-4423-4370 [Term] id: CONSO:CONSO00039 name: AG73 namespace: protein_fragment def: "a peptide derived from mouse laminin alpha 1 protein (seq:RKRLQVQLSIRT, chain:2719–2730)" [pubmed:20615691] relationship: CONSO:author orcid:0000-0002-3034-9970 property_value: bel "p(MGI:Lama1, frag(2719_2730))" xsd:string [Term] id: CONSO:CONSO00040 name: Notch intracellular domain namespace: domain def: "Notch intracellular domain is the intracellular region of notch receptor." [pubmed:20883690] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00041 name: YENPTY endocytosis motif (APP) namespace: motif def: "YENTY is the endocytosis motif of Amyloid precursor protein." [pubmed:18650430] relationship: CONSO:author orcid:0000-0002-0303-8616 synonym: "YENPTY" EXACT [] [Term] id: CONSO:CONSO00042 name: sAPP-beta namespace: protein def: "Soluble amyloid precursor protein" [pubmed:21606494] relationship: CONSO:author orcid:0000-0002-0303-8616 synonym: "soluble amyloid precursor protein" EXACT [] [Term] id: CONSO:CONSO00043 name: growth factor def: "A growth factor is a naturally occurring substance capable of stimulating cellular growth, proliferation, healing, and cellular differentiation. Usually it is a protein or a steroid hormone. Growth factors are important for regulating a variety of cellular processes." [pubmed:14678766] xref: ncit:C20424 xref: umls:C0018284 relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00044 name: 3R tau namespace: protein_isoform_family def: "Tau isoforms containing 3 tubulin binding repeats" [pubmed:23407988] relationship: CONSO:has_reference_protein uniprot:P10636 relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00045 name: 4R tau namespace: protein_isoform_family def: "Tau isoforms containing 4 tubulin binding repeats" [pubmed:23407988] relationship: CONSO:has_reference_protein uniprot:P10636 relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00046 name: VQIINK motif namespace: motif def: "A hexapeptide motif located in the R2, that promotes the formation of PHF" [pubmed:17493042] relationship: bfo:0000050 CONSO:CONSO00003 relationship: CONSO:author orcid:0000-0001-9661-5277 synonym: "PHF6* " EXACT [pubmed:25775228] [Term] id: CONSO:CONSO00047 name: VQIVYK motif namespace: motif def: "A hexapeptide motif located in the R3, that promotes the formation of PHF" [pubmed:17493042] relationship: bfo:0000050 CONSO:CONSO00004 relationship: CONSO:author orcid:0000-0001-9661-5277 synonym: "PHF6" EXACT [pubmed:25775228] [Term] id: CONSO:CONSO00048 name: ghost tangles namespace: cellular_component def: "Extracellular NFT remains after neuron death, considered to be the last stage of NFT-related pathological activity." [pubmed:23407988, pubmed:8431763] is_a: go:0097418 ! neurofibrillary tangle relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00049 name: pretangles namespace: cellular_component def: "Pretangles are cytoplasmic tau immunoreactivity in neurons without apparent formation of fibrillary structures. In Alzheimer disease, such tau deposition is considered to represent a premature state prior to fibril formation (AD-pretangles), later to form neurofibrillary tangles and finally ghost tangles." [pubmed:23407988, pubmed:24612177] is_a: go:0097418 ! neurofibrillary tangle relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00050 name: projection domain namespace: domain def: "Corresponding roughly to the N-terminal part of the tau molecule, consisting mainly of acidic residues and containing two distinct alternatively spliced N-terminal inserts." [pubmed:17493042, pubmed:28386764] xref: interpro:IPR013588 relationship: CONSO:author orcid:0000-0001-9661-5277 synonym: "MAP2/Tau projection" EXACT [] [Term] id: CONSO:CONSO00051 name: RAC1b namespace: isoform def: "A constitutively active splicing isoform of RAC1 (Ras-related C3 botulinum toxin substrate 1), first identified in breast and colon cancer." [pubmed:22142809] xref: uniprot.isoform:P63000-2 relationship: CONSO:has_reference_protein uniprot:P63000 relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00052 name: AP-2 complex namespace: protein_complex def: "A heterotetrameric adapter protein complex involved in cargo-internalization during clathrin-mediated endocytosis. Composed of alpha and beta subunits (large adaptins), mu and sigma subunits (minor adaptins)." [pubmed:27260836] xref: go:0030122 relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00053 name: Tau isoform F (441 aa) namespace: isoform def: "Longest tau isoform in human brain, most commonly used as the conventional tau." [pubmed:17493042] xref: ncbiprotein:NP_005901 xref: uniprot.isoform:P10636-8 is_a: CONSO:CONSO00045 ! 4R tau relationship: CONSO:has_reference_protein uniprot:P10636 relationship: CONSO:author orcid:0000-0001-9661-5277 synonym: "2N4R" EXACT [] synonym: "htau40" EXACT [pubmed:19226187] synonym: "microtubule-associated protein tau isoform 2" EXACT [] [Term] id: CONSO:CONSO00054 name: Tau isoform Fetal-tau (352 aa) namespace: isoform def: "Human fetal tau isoform." [pubmed:17493042] xref: ncbiprotein:NP_058525 xref: uniprot.isoform:P10636-2 relationship: CONSO:has_reference_protein uniprot:P10636 relationship: CONSO:author orcid:0000-0001-9661-5277 synonym: "0N3R" EXACT [] synonym: "htau23" EXACT [pubmed:7667312] synonym: "microtubule-associated protein tau isoform 4" EXACT [] [Term] id: CONSO:CONSO00055 name: Tau isoform B (381 aa) namespace: isoform def: "Human brain tau isoform, derived from alternative splicing." [pubmed:17493042] xref: ncbiprotein:NP_001190180 xref: uniprot.isoform:P10636-4 is_a: CONSO:CONSO00044 ! 3R tau relationship: CONSO:has_reference_protein uniprot:P10636 relationship: CONSO:author orcid:0000-0001-9661-5277 synonym: "1N3R" EXACT [] synonym: "htau37" EXACT [pubmed:22762014] synonym: "microtubule-associated protein tau isoform 7" EXACT [] [Term] id: CONSO:CONSO00056 name: Tau isoform D (383 aa) namespace: isoform def: "Human brain tau isoform, derived from alternative splicing." [pubmed:17493042] xref: ncbiprotein:NP_058518 xref: uniprot.isoform:P10636-6 is_a: CONSO:CONSO00045 ! 4R tau relationship: CONSO:has_reference_protein uniprot:P10636 relationship: CONSO:author orcid:0000-0001-9661-5277 synonym: "0N4R" EXACT [] synonym: "htau24" EXACT [pubmed:22762014] synonym: "microtubule-associated protein tau isoform 3" EXACT [] [Term] id: CONSO:CONSO00057 name: Tau isoform C (410 aa) namespace: isoform def: "Human brain tau isoform, derived from alternative splicing." [pubmed:17493042] xref: ncbiprotein:NP_001190181 xref: uniprot.isoform:P10636-5 is_a: CONSO:CONSO00044 ! 3R tau relationship: CONSO:has_reference_protein uniprot:P10636 relationship: CONSO:author orcid:0000-0001-9661-5277 synonym: "2N3R" EXACT [] synonym: "htau39" EXACT [pubmed:22762014] synonym: "microtubule-associated protein tau isoform 8" EXACT [] [Term] id: CONSO:CONSO00058 name: Tau isoform E (412 aa) namespace: isoform def: "Human brain tau isoform, derived from alternative splicing." [pubmed:17493042] xref: ncbiprotein:NP_001116539 xref: uniprot.isoform:P10636-7 is_a: CONSO:CONSO00045 ! 4R tau relationship: CONSO:has_reference_protein uniprot:P10636 relationship: CONSO:author orcid:0000-0001-9661-5277 synonym: "1N4R" EXACT [] synonym: "htau34" EXACT [pubmed:22762014] synonym: "microtubule-associated protein tau isoform 5" EXACT [] [Term] id: CONSO:CONSO00059 name: Serpin-enzyme complex receptor namespace: protein def: "?" [pubmed:15160835, pubmed:2160076] relationship: CONSO:author orcid:0000-0002-0303-8616 synonym: "SEC-R" EXACT [] [Term] id: CONSO:CONSO00060 name: neuroinflammation namespace: pathology def: "inflammatory response in the brain and nervous tissue." [pubmed:26306439] xref: go:0150076 relationship: CONSO:author orcid:0000-0002-3034-9970 [Term] id: CONSO:CONSO00061 name: neurotoxicity namespace: pathology def: "happens when a biological, physical or chemical agent cause any adverse effect on the structure and function of the nerves system." [pubmed:18440072] relationship: CONSO:author orcid:0000-0002-3034-9970 [Term] id: CONSO:CONSO00062 name: neurite retraction namespace: pathology def: "when the neurite is unable it outgrow and extend" [pubmed:19022228] relationship: CONSO:author orcid:0000-0002-3034-9970 [Term] id: CONSO:CONSO00063 name: APP695 namespace: isoform def: "the APP gene is located on chromosome 21 in humans with three major isoforms arising from alternative splicing [3]. These are APP695, APP751 and APP770 (containing 695, 751, and 770 amino acids, respectively)" [pubmed:21214928] xref: uniprot.isoform:P05067-4 relationship: CONSO:has_reference_protein uniprot:P05067 relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00064 name: APP751 namespace: isoform def: "the APP gene is located on chromosome 21 in humans with three major isoforms arising from alternative splicing [3]. These are APP695, APP751 and APP770 (containing 695, 751, and 770 amino acids, respectively)" [pubmed:21214928] xref: uniprot.isoform:P05067-8 relationship: CONSO:has_reference_protein uniprot:P05067 relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00065 name: APP770 namespace: isoform def: "the APP gene is located on chromosome 21 in humans with three major isoforms arising from alternative splicing [3]. These are APP695, APP751 and APP770 (containing 695, 751, and 770 amino acids, respectively)" [pubmed:21214928] xref: uniprot.isoform:P05067-1 relationship: CONSO:has_reference_protein uniprot:P05067 relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00066 name: gamma-secretase namespace: protein_complex def: "gamma-secretase is a high molecular weight complex minimally composed of four components: presenilins (PS), nicastrin, anterior pharynx defective 1 (APH-1), and presenilin enhancer 2 (PEN-2)" [pubmed:25565961] xref: fplx:Gamma_secretase relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00067 name: sAPP-alpha namespace: protein def: "soluble amyloid precursor protein-alpha" [pubmed:22491325] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00068 name: Excitotoxicity namespace: pathology def: "Excitotoxicity is defined as cell death resulting from the toxic actions of excitatory amino acids" [pubmed:19343058] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00069 name: C31 namespace: protein_fragment def: "a fragment containing the last 31 amino acids of APP (called C31)" [pubmed:21214928] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00070 name: Jcasp namespace: protein_fragment def: "Additional gamma-cleavage further generates the fragment (called Jcasp) containing the region between gamma- and caspase-cleavage sites" [pubmed:21214928] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00071 name: AICD namespace: domain def: "APP intracellular domain" [pubmed:21214928] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00072 name: p83 namespace: protein_fragment def: "APP alphaCTF and betaCTF are further cleaved by gamma-secretase to generate p83 and Abeta, respectively" [pubmed:21214928] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00073 name: APP processing namespace: biological_process def: "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein (see:GO:0016485)" [pubmed:21214928] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00074 name: AβOs namespace: cellular_component def: "soluble Aβ oligomers" [pubmed:24685176] relationship: CONSO:author orcid:0000-0002-7128-929X [Term] id: CONSO:CONSO00075 name: LMW amyloid oligomers namespace: cellular_component def: "The formation of AβOs starts from alterations in the conformation of monomeric Aβ, resulting in low molecular weight (LMW) dimers and trimers, followed by aggregation to soluble spherical oligomers consisted of 12–24 monomers." [pubmed:18723507] relationship: CONSO:author orcid:0000-0002-7128-929X [Term] id: CONSO:CONSO00076 name: amyloid-beta 40 oligomers namespace: cellular_component def: "Amyloid-beta oligomers composed specifically of amyloid-beta 40" [pubmed:21209907] relationship: CONSO:author orcid:0000-0002-7128-929X [Term] id: CONSO:CONSO00077 name: alternative splicing of APP gene namespace: biological_process def: "The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition (see:GO:0000380)" [pubmed:22122372] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00078 name: E1 domain namespace: domain def: "The ectodomains of APP and APLPs have two conserved regions called E1 and E2 (Fig. 1A), both of which have been proposed to contribute to dimerization" [pubmed:21574595] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00079 name: E2 domain namespace: domain def: "The ectodomains of APP and APLPs have two conserved regions called E1 and E2 (Fig. 1A), both of which have been proposed to contribute to dimerization" [pubmed:21574595] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00080 name: P3 peptide namespace: protein_fragment def: "Cleavage by α-secretase yields the nonamyloidogenic soluble 3-kDa peptide (p3) that does not form amyloid fibrils, whereas cleavage by β-secretase yields the amyloidogenic form Aβ1–40 or the longer, more fibrillogenic Aβ1–42" [pubmed:22137428] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00081 name: C99 namespace: protein_fragment def: "a membrane associated C-terminal fragment consisting of 99 amino acids (C99)" [pubmed:22122372] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00082 name: aMCI namespace: pathology def: "amnestic Mild Cognitive Impairement is a cognitive dysfunction that is associated with memory deficits" [pubmed:18986241] relationship: CONSO:author orcid:0000-0002-3034-9970 [Term] id: CONSO:CONSO00083 name: mdMCI namespace: pathology def: "multi-domain Mild Cognitive Impairement is a cognitive dysfunction that is associated with more than one cognitive domain" [pubmed:18986241] relationship: CONSO:author orcid:0000-0002-3034-9970 [Term] id: CONSO:CONSO00084 name: Tau isoform A (316 aa) namespace: isoform def: "Human brain tau isoform, derived from alternative splicing." [pubmed:18986241] xref: uniprot.isoform:P10636-3 relationship: CONSO:has_reference_protein uniprot:P10636 relationship: CONSO:author orcid:0000-0002-3034-9970 [Term] id: CONSO:CONSO00085 name: Tau C3 namespace: epitope def: "Tau epitope cleaved at aspartic acid(421)." [pubmed:18986241] relationship: CONSO:author orcid:0000-0002-3034-9970 [Term] id: CONSO:CONSO00086 name: Tau MN423 namespace: epitope def: "Tau epitope truncated at glutamic acid(391)." [pubmed:18986241] relationship: CONSO:author orcid:0000-0002-3034-9970 [Term] id: CONSO:CONSO00087 name: granular tau oligomers namespace: cellular_component def: "When the oligomer lengthens, it adapts a beta-sheet structure and transforms into a detergent-insoluble aggregate with granular appearance under Atomic Force Microscopy (AFM)" [pubmed:28420982] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00088 name: Tau fibrils namespace: cellular_component def: "As these granular tau oligomers fuse together, they form tau fibrils, which ultimately form NFTs" [pubmed:28420982] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00089 name: dense core plaques namespace: cellular_component def: "Dense-core plaques are fibrillar deposits of Abeta, showing all the classical properties of amyloid including beta-sheet secondary structure, while diffuse plaques are amorphous deposits" [pubmed:17680701] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00090 name: Tau annular protofibrils namespace: cellular_component def: "A handful of proteins implicated in neurodegenerative diseases have been found to produce pore-like amyloid structures known as annular protofibrils (APFs)" [pubmed:28420982] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00091 name: TOC1 namespace: antibody def: "monoclonal antibody, named TOC1 (tau oligomeric complex 1), which selectively labels tau dimers and oligomers, but does not label filaments" [pubmed:22817713] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00092 name: alpha-synuclein fibrils namespace: cellular_component def: "fibrillar aggregates of alpha-synuclein, found in Lewy bodies" [pubmed:19892735] relationship: CONSO:author orcid:0000-0002-7128-929X [Term] id: CONSO:CONSO00093 name: alpha-synuclein oligomers namespace: cellular_component def: "oligomeric aggregates of alpha-synuclein" [pubmed:17374364] relationship: CONSO:author orcid:0000-0002-7128-929X [Term] id: CONSO:CONSO00094 name: CLR01 namespace: protein def: "the Lys-specific molecular tweezer CLR01 has been shown to inhibit aggregation and toxicity of multiple amyloidogenic protein" [pubmed:23183235] relationship: CONSO:author orcid:0000-0002-7128-929X [Term] id: CONSO:CONSO00095 name: prefibrillar α-synuclein oligomers namespace: cellular_component def: "prefibrillar oligomers formed at early stages of α-syn assembly" [pubmed:27075649] relationship: CONSO:author orcid:0000-0002-7128-929X [Term] id: CONSO:CONSO00096 name: GA-AGE def: "Glyceraldehyde-derived (GA) advanced glycation end products" [pubmed:16630055, pubmed:15221334] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00097 name: TGM2 Isoform 3 (349 aa) namespace: isoform def: "Short isoform of tissue transglutaminase" [pubmed:12578227] xref: uniprot.isoform:P21980-2 relationship: CONSO:has_reference_protein uniprot:P21980 relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00098 name: KXGS motif namespace: motif def: "Conserved Tau phosphorylation motif. Part of the microtubule-binding region, phosphorylation of the serine in these motifs disrupts tau binding to the MT and serves to regulate tau-mediated MT assembly" [pubmed:17304350, pubmed:21215781] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00099 name: Corticobasal Degeneration namespace: pathology def: "CBD is a late-onset neurodegenerative disease involving the cerebral cortex and the basal ganglia, characterized by widespread deposition of hyperphosphorylated 4-repeat tau in neurons and glia, the latter as astrocytic plaques" [pubmed:22057784] is_a: CONSO:CONSO00233 ! 4R tauopathy relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00100 name: paired helical filaments namespace: cellular_component def: "Component of NFT, consisting in a helical arrangement of tau protomers" [pubmed:22496370, pubmed:1706519] relationship: bfo:0000050 GO:GO:0097418 relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00101 name: straight filaments namespace: cellular_component def: "Component of NFT and ultrastructural polymorph of PHFs, with an assymetrical arrangement of the tau protomers" [pubmed:16566606, pubmed:28678775] relationship: bfo:0000050 GO:GO:0097418 relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00102 name: Alz50 namespace: antibody def: "Murine IgM-class monoclonal antibody recognizing a specific conformational epitope adopted by tau during PHF formation" [pubmed:16566606, pubmed:8955115] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00103 name: O-GlcNAcylation namespace: post_translational_modification def: "A non-canonical glycosylation involving the attachment of single O-linked N-acetylglucosamine (O-GlcNAc) moieties to serine and threonine residues of cytoplasmic, nuclear, and mitochondrial proteins" [pubmed:16630055] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00104 name: glycation namespace: post_translational_modification def: "The non-enzymatic reaction between the electrophilic carbonyl groups of a reducing sugar and the free amino groups of tau amino acids (especially of basic lysine or arginine residues) leading to the formation of a ketoamine (Amadori product), an intermediate of AGE synthesis." [pubmed:26655600] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00105 name: nitration namespace: post_translational_modification def: "Incorporation of a nitrogen dioxide (NO2) group in tyrosine residues (mostly) of proteins forming 3-nitrotyrosine (3-NT). A biomarker of cell, tissue and systemic nitrosative stress." [pubmed:16566606] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00106 name: polyamination namespace: post_translational_modification def: "The reaction of polyamination by transglutaminases (TGs) involves a glutamine (Q) as acyl donor and a lysine (K) as acyl acceptor. It generates a (gamma)-glutamyl-(epsilon)-lysine isopeptide bond that causes protein cross-linking" [pubmed:25974414] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00107 name: formylation namespace: post_translational_modification def: "The addition of a formyl functional group usually at the epsilon amino group of Lys residues" [pubmed:21210655] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00108 name: Syndecan Family namespace: protein_family def: "IterPro:IPR001050" [pubmed:15241784] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00109 name: Bacterial invasion namespace: biological_process def: "The process of bacteria invading a cell" [pubmed:15241784] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00110 name: dopamine homeostasis namespace: biological_process def: "Dopmine secrete in a homeostatic way" [pubmed:26325389] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00111 name: PINK1-Park pathway namespace: pathway def: "The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo.pubmed:23509287" [pubmed:26182419] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00112 name: Glutamate excitotoxicity namespace: biological_process def: "The excitotoxicity of Glutamate" [pubmed:10196525] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00113 name: mitochondrial homeostasis namespace: biological_process def: "The interplay between mitophagy and mitochondrial biogenesis." [pubmed:25478815] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00114 name: ER mitochondria interorganellar crosstalk namespace: biological_process def: "reference:pubmed:22577383" [pubmed:25478815] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00115 name: Mitochondrial pathway namespace: pathway def: "reference:pubmed:22399422" [pubmed:23313576] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00116 name: oxidative protein folding namespace: biological_process def: "Oxidative protein folding is a process that is responsible for the formation of disulfide bonds between cysteine residues in proteins. The driving force behind this process is a redox reaction, in which electrons pass between several proteins and finally to a terminal electron acceptor." [pubmed:26004228] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00117 name: mitochondrial motility namespace: biological_process def: "The motility of mitochondria" [pubmed:25565208] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00118 name: TIM/TOM complex namespace: protein_complex def: "The TIM/TOM complex is a protein complex in cellular biochemistry which translocates proteins produced from nuclear DNA through the mitochondrial membrane for use in oxidative phosphorylation. Only 13 proteins necessary for a mitochondrion are actually coded in mitochondrial DNA." [pubmed:25565208] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00119 name: mitochondrial aggregation namespace: biological_process def: "The aggregation of mitochondria" [pubmed:25591737] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00120 name: mevalonate pathway namespace: pathway def: "The mevalonate pathway, also known as the isoprenoid pathway or HMG-CoA reductase pathway is an essential metabolic pathway present in eukaryotes, archaea, and some bacteria" [pubmed:24695221] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00121 name: Dopaminergic cell groups namespace: anatomy def: "UBERON:dopaminergic cell groups" [pubmed:24695221] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00122 name: mitochondrial precursor protein namespace: protein def: "The precursor protein of mitochondria" [pubmed:26192197] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00123 name: PDR-1 namespace: protein def: "the nematode homolog of Parkin" [pubmed:26430570] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00124 name: PINK-1 namespace: protein def: "the nematode homolog of PINK1" [pubmed:26430570] xref: ncbigene:173918 xref: wb:WBGene00017137 relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00125 name: skn-1 namespace: protein def: "the nematode homolog of Skn1" [pubmed:25896323] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00126 name: ced-9 namespace: protein def: "the nematode homolog of Bcl-2" [pubmed:25896323] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00127 name: lgg-1 namespace: protein def: "the nematode homolog of Lgg1" [pubmed:25896323] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00128 name: clec-65 namespace: protein def: "the nematode homolog of Clec65" [pubmed:25896323] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00129 name: clec-4 namespace: protein def: "the nematode homolog of Clec4" [pubmed:25896323] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00131 name: exotoxin A namespace: protein def: "exotoxin A is an exotoxin produced by Pseudomonas aeruginosa.It inhibits elongation factor-2. It does so by ADP-ribosylation of EF2. This then causes the elongation of polypeptides to cease." [pubmed:25274306] relationship: CONSO:inhibitor HGNC:HGNC:3214 relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00132 name: mitochondrial DAMPs def: "mitochondrial damage-associated molecular patterns" [pubmed:20203610] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00133 name: IκB kinase namespace: protein_complex def: "The IκB kinase is an enzyme complex that is involved in propagating the cellular response to inflammation." [pubmed:19880420] xref: fplx:IKK_family relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00134 name: non-shivering thermogenesis namespace: biological_process def: "Nonshivering thermogenesis was originally defined as a cold-induced increase in heat production not associated with the muscle activity of shivering. Recent research shows it to be a metabolic process located primarily in brown adipose tissue and controlled by the activity of the sympathetic nervous supply of this tissue" [pubmed:16224498, pubmed:6722594] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00135 name: hsp-16 namespace: protein def: "the nematode homologus of hsp16" [pubmed:22700657] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00136 name: heat shock proteins namespace: protein_family def: "Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions. They were first described in relation to heat shock," [pubmed:15280428] xref: mesh:D006360 relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00137 name: high-calorie diets namespace: exposure def: "Diets with high calorie." [pubmed:10412986] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00138 name: proteotoxicity namespace: pathology def: "To function, proteins must undergo a folding process that gives them the proper three dimensional structure. Numerous genetic and biochemical observations suggest that proteins that fail to fold properly impair cell function. This process, also referred to as proteotoxicity, is particularly important to the fate of non-renewable cells of long-lived organisms in which malfolded proteins (proteotoxins) can exert their deleterious influence over extended periods of time.reference:Proteotoxicity and Aging" [pubmed:24149988] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00139 name: ss20399075 namespace: genetic_variant def: "A SNP located within the 3' UTR of FGF20, is significantly associated with PD risk" [pubmed:15122513] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00140 name: Alpha-synuclein Oligomerization namespace: biological_process def: "The formation of alpha-synuclein oligmer" [pubmed:21296890] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00141 name: D6S253 def: "A microsatellite markers for Alzheimer’s and Parkinson’s Diseases" [pubmed:9560156] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00142 name: D6S305 def: "A microsatellite markers for Alzheimer’s and Parkinson’s Diseases" [pubmed:9560156] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00143 name: MTHFR,TT+AA def: "In Parkinson's Disease, TT+AA is more frequent in MTHFR gene." [pubmed:17914182] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00144 name: CAG repeats namespace: motif def: "CAG repeats in genes." [pubmed:22782013] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00145 name: Gastrointestinal dysfunctions namespace: pathology def: "The function of gastrotestine disorder." [pubmed:24467967] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00146 name: olfactory epithelium namespace: anatomy def: "UBERON:olfactory epithelium" [pubmed:22691461] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00147 name: nasal cycle def: "The nasal cycle is the often unnoticed alternating partial congestion and decongestion of the nasal cavities in humans and other animals. It is a physiological congestion of the nasal concha, also called the nasal turbinate, due to selective activation of one half of the autonomic nervous system by the hypothalamus." [pubmed:23569018] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00148 name: hyposmia namespace: pathology def: "Hyposmia is a reduced ability to smell and to detect odors.Hyposmia might be a very early sign of Parkinson's disease. Hyposmia is also an early and almost universal finding in Alzheimer's disease and dementia with Lewy bodies. Lifelong hyposmia could be caused by Kallmann syndrome." [pubmed:23933572] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00149 name: FMR1,(55-200 CGG) namespace: genetic_variant def: "A premutation (PM) expansion (55-200 CGG) in the fragile X mental retardation gene 1 causes elevated messenger RNA and reduced fragile X mental retardation gene 1 protein." [pubmed:24332449] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00150 name: pof14 def: "a new member of the F-box family, Pof14, which forms a canonical" [pubmed:17016471] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00151 name: Neuroglia namespace: anatomy def: "MeSH Unique ID: D009457" [pubmed:19248803] xref: mesh:D009457 relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00152 name: GDNF Family namespace: chemical_class def: "The GDNF family of ligands (GFL) consists of four neurotrophic factors: glial cell line-derived neurotrophic factor (GDNF), neurturin (NRTN), artemin (ARTN), and persephin (PSPN). GFLs have been shown to play a role in a number of biological processes including cell survival, neurite outgrowth, cell differentiation and cell migration. In particular signalling by GDNF promotes the survival of dopaminergic neurons." [pubmed:10383122] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00153 name: Motor Neurons namespace: anatomy def: "MeSH Unique ID: D009046" [pubmed:10383122] xref: mesh:D009046 relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00154 name: noradrenergic neuron namespace: anatomy def: "Cell:noradrenergic neuron" [pubmed:10383122] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00155 name: midbrain dopaminergic neuron namespace: anatomy def: "Cell:midbrain dopaminergic neuron" [pubmed:10383122] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00156 name: Neurites namespace: anatomy def: "A neurite or neuronal process refers to any projection from the cell body of a neuron." [pubmed:23872421] xref: mesh:D016501 relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00157 name: GRB10,BPS domain namespace: domain def: "BPS domain of protein GRB10" [pubmed:25268761] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00158 name: common fragile site namespace: cellular_component def: "A chromosomal fragile site is a specific heritable point on a chromosome that tends to form a gap or constriction and may tend to break when the cell is exposed to partial replication stress.Based on their frequency, fragile sites are classified as common or rare.To date, more than 120 fragile sites have been identified in the human genome." [pubmed:12874785] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00159 name: PARK7-alpha helices namespace: domain def: "The alpha helices of PARK7 protein" [pubmed:18707128] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00160 name: cleaved PINK1 namespace: protein_fragment def: "The cleaved part of Protein PINK1" [pubmed:21138942] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00161 name: neurovascular unit namespace: anatomy def: "The brain hyperaemia, or coupling, is accomplished by a group of cells, closely related to each other; called neurovascular unit (NVU). The neurovascular unit is composed by neurones, astrocytes, endothelial cells of blood-brain barrier (BBB), myocytes, pericytes and extracellular matrix components" [pubmed:25136294, pubmed:24629161] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00162 name: Muscles namespace: anatomy def: "MeSH Unique ID: D009132" [pubmed:21151955] xref: mesh:D009132 relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00163 name: Neural Stem Cell namespace: anatomy def: "MeSH Unique ID: D058953" [pubmed:22357600] xref: mesh:D058953 relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00164 name: Ventral Tegmental Area namespace: anatomy def: "MeSH Unique ID: D017557" [pubmed:16190884] xref: mesh:D017557 relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00165 name: Pars Compacta namespace: anatomy def: "MeSH Unique ID: D065842" [pubmed:16190884] xref: mesh:D065842 relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00166 name: proline-rich domain namespace: domain def: "Correspounding to residues I151 to Q244 of the 441 aa tau isoform, separated into P1 and P2. Possible role in tau's functional stabilization through the reported intramolecular interaction of P2 with R1, R2 and R4 from the microtubule-binding region" [pubmed:25974414, pubmed:8068626, pubmed:9190213] relationship: CONSO:author orcid:0000-0001-9661-5277 synonym: "P domain" EXACT [pubmed:8068626] synonym: "PRD" EXACT [pubmed:26789759] [Term] id: CONSO:CONSO00167 name: lys-2 namespace: protein def: "the nematode homolog of Lys2" [pubmed:25896323] relationship: CONSO:author orcid:0000-0003-4423-4370 [Term] id: CONSO:CONSO00168 name: abf-2 namespace: protein def: "the nematode homolog of Abf2" [pubmed:25896323] relationship: CONSO:author orcid:0000-0003-4423-4370 [Term] id: CONSO:CONSO00169 name: hydrophobic pocket of actin namespace: domain def: "The lower cleft between domains 1 and 3 is lined by residues Tyr143, Ala144, Gly146, Thr148, Gly168, Ile341, Ile345, Leu346, Leu349, Thr351, and Met355, which are predominantly hydrophobic. This cleft constitutes the major binding site for most ABPs and also mediates important longitudinal contacts between actin subunits in the filament" [pubmed:21314430] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00170 name: 310-helix namespace: motif def: "The 310-helix is the fourth most common type of secondary structure in proteins after α-helices, β-sheets, and reverse turns (Barlow and Thornton 1988). Approximately 15%–20% of all helices in protein structures are 310-helices, which are commonly found as N- or C-terminal extensions to an α-helix (Barlow and Thornton 1988). 310-Helices in proteins are typically only three to five residues long compared with a mean of 10–12 residues for α-helices (Richardson and Richardson 1988)" [pubmed:12761385] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00171 name: Amylin Antagonist AC253 namespace: peptide def: "Amino Acid Sequence: Ac-Leu-Gly-Arg-Leu-Ser-Gln-Glu-Leu-His-Arg-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2" [pubmed:22500019] relationship: CONSO:author orcid:0000-0002-3034-9970 [Term] id: CONSO:CONSO00172 name: CDK5R1 p25 namespace: protein def: "The cyclin dependent kinase 5 regulatory subunit 1 (CDK5R1), also known as p35, is cleaved by Calpain to produce the p25 fragment" [pubmed:10830966] relationship: CONSO:author orcid:0000-0002-3034-9970 property_value: bel "p(HGNC:CDK5R1, frag(99_307))" xsd:string [Term] id: CONSO:CONSO00173 name: PTI-125 namespace: chemical_proprietary def: "PTI-125 is a proprietary small molecule that preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its alpha7nAChR/TLR4 associations and downstream pathologies" [pubmed:28438486, pubmed:22815492] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00174 name: alpha-4 beta-2 nAChR namespace: protein_complex def: "In addition to nAChRs forming from different subunit assemblages, stoichiometric study has shown that α4β2 nAChRs can form as either (α4)3(β2)2 or (α4)2(β2)3, the latter having a greater affinity for both nicotine and Ach" [pubmed:24828779] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00175 name: alpha-7 beta-2 nAChR namespace: protein_complex def: "Accumulating evidence demonstrates that these α7 and β2 nAChR subunits can co-assemble to form functional α7β2 nAChRs in heterologous expression systems, and also under natural conditions in the brain (Figure 1)" [pubmed:27179601] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00176 name: beta-2-containing nAChR namespace: protein_complex def: "The β2 subunit can couple with non-α4 subunits, including α2, α3 and α6 subunits to form functionally distinct nAChRs, but these receptors are much less densely expressed in the central nervous system relative to α4β2* nAChRs (*indicating potential assemblage of β2 subunits with non-α4 subunits)" [pubmed:24828779] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00177 name: Abeta*56 namespace: cellular_component def: "56 kDa soluble amyloid-β (Aβ) assembly" [pubmed:16541076] relationship: CONSO:author orcid:0000-0002-3034-9970 [Term] id: CONSO:CONSO00178 name: protein aggregates namespace: cellular_component def: "Aggregates of proteins or fragments of proteins" [pmc:PMC2633703, pubmed:23254192, pubmed:12747895, pubmed:23484434] xref: mesh:D066329 xref: sbo:0000543 relationship: CONSO:author orcid:0000-0003-4423-4370 [Term] id: CONSO:CONSO00179 name: sAPP-gamma namespace: protein_fragment def: "results from the cleavage of beta APP by gamma-secretase" [pubmed:12105112] relationship: CONSO:author orcid:0000-0002-3034-9970 [Term] id: CONSO:CONSO00180 name: alpha-6-containing nAChR namespace: protein_complex def: "alpha6-containing receptors, which in brain occur as heteropentamers with beta2 and beta3 and are especially enriched in presynaptic nerve terminals in striatum (Champtiaux et al.,2002)" [pubmed:28445721, pubmed:19498417] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00181 name: phosphatase-activating domain namespace: domain def: "Tau domain located in the N-terminal region encompassing residues 2-18. It activates phosphatase PP1 which dephosphorylates Ser9 in GSK3Beta and leads to its activation. In normal tau, both NTD and CTD are folded back in proximity to each other forming a 'paper-clip' conformation, which masks the PAD. Phosphorylation in the AT8 epitope, disrupts this normal conformational state, exposing the PAD by moving away the terminal domains." [pubmed:26671985, pubmed:28413156] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00182 name: cystein-dependent auto-acetylation namespace: biological_process def: "Autocatalytic cysteine-mediated acetylation of Lys residues in the MTBR upon incubation of tau proteins with acetyl-CoA, possible even in absence of enzymatic activity.This activity may be suppressed when tau is bound to tubulin or MTs, but activated upon tau dissociation during pathological conditions that abrogate tau-MT interactions, thus allowing acetyl-CoA accessibility to free tau cysteines." [pubmed:28002468, pubmed:27383765] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00183 name: GVD bodies namespace: cellular_component def: "Pathological hallmarks of Alzheimer Disease, consisting in intraneuronal accumulations of large membrane-bound vacuoles. Associated with the late stages of disease progression, they were also shown to be immunopositive or GSK3Beta and SYK (Spleen Tyrosine Kinase)." [pubmed:26501932] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00184 name: advanced glycation end product namespace: chemical_class def: "Advanced glycation end products (AGEs) are the production of Maillard reaction between carbohydrates and proteins. They cause neurotoxicity via production of ROS followed by an increase in expression of APP and amyloid beta. Recent analysis implicates them in tau phosphorylation." [pubmed:28176663] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00185 name: long-term potentiation def: "A long lasting enhancement in synaptic transmission between two neurons, most commonly studied in the synapse between the Schaffer collateral axons of the CA3 neurons and the CA1 pyramidal neurons of the hippocampus. Alongside the LTD (long-term depression) represent the two mechanisms of memory formation and storage. Impairment of this process in AD is caused by soluble oligmoeric amyloid beta." [pubmed:27041503] xref: mesh:D017774 relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00186 name: proline-rich region 1 namespace: domain def: "Part of the wider proline-rich domain, divided between the projection and assembly domains, this region together with the MTBR mediate tau interaction and binding to F actin." [pubmed:21757739] relationship: bfo:0000050 CONSO:CONSO00050 relationship: bfo:0000050 CONSO:CONSO00166 relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00187 name: proline-rich region 2 namespace: domain def: "Part of the wider proline-rich domain, divided between the projection and assembly domains, this region together with the MTBR mediate tau interaction and binding to F actin." [pubmed:21757739] relationship: bfo:0000050 CONSO:CONSO00166 relationship: bfo:0000050 CONSO:CONSO00188 relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00188 name: assembly domain namespace: domain def: "Tau assembly domain consists of the second part of the proline-rich region (PR2), MTBR and CTD, corresponding to residues 199-441 of the canonical tau isoform." [pubmed:21757739] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00189 name: CRL4 complex namespace: protein_complex def: "Cullin-RING E3 ubiquitin ligase complex 4, consisting of CUL4(A,B), DDB1 and CRBN." [pubmed:27325702] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00190 name: APP, ACR namespace: domain def: "Cytosolic region of APP, responsible for interacting with E3 ubiquitin ligases among other proteins." [pubmed:27325702] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00191 name: tubulin detyrosination namespace: post_translational_modification def: "Detyrosination is a form of posttranslational modification that occurs on alpha-tubulin. It consists of the removal of the C-terminal tyrosine to expose a glutamate at the newly formed C-terminus. Promoted by Tau truncation in the Gln124 residue." [pubmed:25974414] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00192 name: Microgliosis namespace: biological_process def: "An intense reaction of microglia following CNS insult, characterized by active proliferation and retracted cellular processes. In AD, accumulation of Abeta can be a possible cause of such physiological phenomenon, as microglia is seen surrounding senile plaques. Abeta interaction with microglial pattern recognition receptors (PRRs) leads to NLRP3 inflammasome activation, production of toxic NOS and ROS and release of proinflammatory cytokines." [pubmed:29121589] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00193 name: Astrogliosis namespace: biological_process def: "Morphological and functional changes observed in astrocytes in the context of their physiological response to CNS trauma or injury caused by ischemia, stroke, autoimmune disorders and neurodegeneration." [pubmed:29121589] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00194 name: CK1 superfamily namespace: protein_family def: "The CK1 group of eukaryotic protein kinases are composed of seven CK1 isoforms (CK1α, CK1α2, CK1δ, CK1ε, CK1γ1, CK1γ2, and CK1γ3), two Tau–tubulin kinase isoforms (TTBK1 and TTBK2), and three VRK isoforms (VRK1, VRK2, and VRK3)" [pubmed:25673844] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00195 name: alpha-4-containing nAChR namespace: protein_complex def: "nAChRs that bind radiolabeled nicotine with the highest affinity contain a4 subunits (a4*-nAChR)" [pubmed:21787755] relationship: CONSO:author orcid:0000-0002-7128-929X [Term] id: CONSO:CONSO00196 name: alpha-4 beta-4 nAChR namespace: protein_complex def: "a4 subunits can also assemble with b4 subunits to form a4b4-nAChRs that have comparably high nicotine affinity" [pubmed:21787755] relationship: CONSO:author orcid:0000-0002-7128-929X [Term] id: CONSO:CONSO00197 name: alpha-7-containing nAChR namespace: protein_complex def: "Another prominent nAChR subtype found in vertebrate central and autonomic nervous systems contains a7 subunits." [pubmed:21787755] relationship: CONSO:author orcid:0000-0002-7128-929X [Term] id: CONSO:CONSO00198 name: alpha-Bungarotoxin namespace: protein def: "Neurotoxic proteins from the venom of the banded or Formosan krait (Bungarus multicinctus, an elapid snake)." [pubmed:21787755] xref: uniprot:P60616 relationship: CONSO:author orcid:0000-0002-7128-929X [Term] id: CONSO:CONSO00199 name: alpha-3 beta-2 nAChR namespace: protein_complex def: "nAChRs containing the a3b2 subunit interface" [pubmed:21787755] relationship: CONSO:author orcid:0000-0002-7128-929X [Term] id: CONSO:CONSO00200 name: kappa-Bungarotoxin namespace: protein def: "kappa-Bungarotoxin, a snake venom kappa-neurotoxin, is a potent neuronal nicotinic receptor antagonist (pubmed:3359187)" [pubmed:21787755, pubmed:3359187] xref: uniprot:P01398 relationship: CONSO:author orcid:0000-0002-7128-929X [Term] id: CONSO:CONSO00201 name: VU10010 namespace: chemical def: "highly selective M4 (mAChR) allosteric potentiator. Chemical name: 3-Amino-N-[(4-chlorophenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide" [pubmed:24511233, pubmed:18059262] xref: cas:633283-39-3 xref: inchi:InChI=1S/C17H16ClN3OS/c1-9-7-10\(2\)21-17-13\(9\)14\(19\)15\(23-17\)16\(22\)20-8-11-3-5-12\(18\)6-4-11/h3-7H\,8\,19H2\,1-2H3\,\(H\,20\,22\) xref: pubchem.compound:714286 xref: smiles:CC1=C2C\(SC\(C\(NCC3=CC=C\(Cl\)C=C3\)=O\)=C2N\)=NC\(C\)=C1 relationship: CONSO:author orcid:0000-0002-6117-4413 synonym: "2-Fly" EXACT [pubchem.compound:714286] synonym: "2-Furoyl-LIGRLO-amide trifluoroacetate salt" EXACT [pubchem.compound:714286] synonym: "2-Furoyl-LIGRLO-amide trifluoroacetate salt, >=97% (HPLC)" EXACT [pubchem.compound:714286] synonym: "2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2 trifluoroacetate salt" EXACT [pubchem.compound:714286] synonym: "2-f-LIGRLO-NH2" EXACT [pubchem.compound:714286] synonym: "2-fAP" EXACT [pubchem.compound:714286] synonym: "2fLI" EXACT [pubchem.compound:714286] synonym: "3-Amino-N-(4-chlorobenzyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide 2,2,2-trifluoroacetate" EXACT [pubchem.compound:714286] synonym: "3-amino-N-(4-chlorobenzyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide" EXACT [pubchem.compound:714286] synonym: "3-amino-N-[(4-chlorophenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide" EXACT [pubchem.compound:714286] synonym: "633283-39-3" EXACT [pubchem.compound:714286] synonym: "A3274/0139289" EXACT [pubchem.compound:714286] synonym: "AC1LEM0C" EXACT [pubchem.compound:714286] synonym: "AKOS000282930" EXACT [pubchem.compound:714286] synonym: "B7285" EXACT [pubchem.compound:714286] synonym: "BDBM50323691" EXACT [pubchem.compound:714286] synonym: "CHEMBL1212994" EXACT [pubchem.compound:714286] synonym: "CTK5B8654" EXACT [pubchem.compound:714286] synonym: "D0N2VN" EXACT [pubchem.compound:714286] synonym: "DTXSID30351931" EXACT [pubchem.compound:714286] synonym: "FPRULFHDSFKYBV-UHFFFAOYSA-N" EXACT [pubchem.compound:714286] synonym: "HMS3431D09" EXACT [pubchem.compound:714286] synonym: "KB-81468" EXACT [pubchem.compound:714286] synonym: "MCULE-8947006791" EXACT [pubchem.compound:714286] synonym: "MLS002474501" EXACT [pubchem.compound:714286] synonym: "MolPort-002-722-568" EXACT [pubchem.compound:714286] synonym: "NCGC00378784-01" EXACT [pubchem.compound:714286] synonym: "RT-016241" EXACT [pubchem.compound:714286] synonym: "SMR001398666" EXACT [pubchem.compound:714286] synonym: "SR-01000147542" EXACT [pubchem.compound:714286] synonym: "SR-01000147542-1" EXACT [pubchem.compound:714286] synonym: "STL227650" EXACT [pubchem.compound:714286] synonym: "VU 10010" EXACT [pubchem.compound:714286] synonym: "VU-10010" EXACT [pubchem.compound:714286] synonym: "VU0402469-1" EXACT [pubchem.compound:714286] synonym: "VU10010" EXACT [pubchem.compound:714286] synonym: "ZINC109066" EXACT [pubchem.compound:714286] synonym: "cid_714286" EXACT [pubchem.compound:714286] synonym: "f-LIGRLO-NH2" EXACT [pubchem.compound:714286] [Term] id: CONSO:CONSO00202 name: VU0456940 namespace: chemical def: "M1-selective PAM that potentiates M1 (mAChR). Chemical name:1-[4,6-difluoro-1-[6-(1-methylpyrazol-4-yl)pyridin-3-yl]indol-3-yl]sulfonyl-3-(5-methyl-1,2-oxazol-3-yl)propan-2-one" [pubmed:24511233] xref: inchi:InChI=1S/C24H19F2N5O4S/c1-14-5-17\(29-35-14\)8-19\(32\)13-36\(33\,34\)23-12-31\(22-7-16\(25\)6-20\(26\)24\(22\)23\)18-3-4-21\(27-10-18\)15-9-28-30\(2\)11-15/h3-7\,9-12H\,8\,13H2\,1-2H3 xref: iupac:1-\[4\,6-difluoro-1-\[6-\(1-methylpyrazol-4-yl\)pyridin-3-yl\]indol-3-yl\]sulfonyl-3-\(5-methyl-1\,2-oxazol-3-yl\)propan-2-one xref: smiles:CN1N=CC\(C2=CC=C\(N3C=C\(S\(=O\)\(CC\(CC4=NOC\(C\)=C4\)=O\)=O\)C5=C3C=C\(F\)C=C5F\)C=N2\)=C1 relationship: CONSO:author orcid:0000-0002-6117-4413 synonym: "VU 0456940" EXACT [https://medkoo.com/products/9998] synonym: "VU-0456940" EXACT [https://medkoo.com/products/9998] synonym: "VU0456940" EXACT [https://medkoo.com/products/9998] [Term] id: CONSO:CONSO00203 name: VU0152099 namespace: chemical def: "selective M4 (mAChR) allosteric potentiator. Chemical name: 3-Amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide" [pubmed:24511233] xref: inchi:InChI=1S/C18H17N3O3S/c1-9-5-10\(2\)21-18-14\(9\)15\(19\)16\(25-18\)17\(22\)20-7-11-3-4-12-13\(6-11\)24-8-23-12/h3-6H\,7-8\,19H2\,1-2H3\,\(H\,20\,22\) xref: pubchem.compound:1541501 xref: smiles:CC1=CC\(=NC2=C1C\(=C\(S2\)C\(=O\)NCC3=CC4=C\(C=C3\)OCO4\)N\)C xref: wikidata:Q27089173 relationship: CONSO:author orcid:0000-0002-6117-4413 synonym: "3-amino-4,6-dimethyl-N-piperonyl-thieno[2,3-b]pyridine-2-carboxamide" EXACT [pubchem.compound:1541501] synonym: "3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethyl-2-thieno[2,3-b]pyridinecarboxamide" EXACT [pubchem.compound:1541501] synonym: "3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide" EXACT [pubchem.compound:1541501] synonym: "3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[5,4-b]pyridine-2-carboxamide" EXACT [pubchem.compound:1541501] synonym: "3-amino-N-(2H-1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide" EXACT [pubchem.compound:1541501] synonym: "3-amino-N-(benzo[d][1,3]dioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine carboxamide" EXACT [pubchem.compound:1541501] synonym: "3-azanyl-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxamide" EXACT [pubchem.compound:1541501] synonym: "612514-42-8" EXACT [pubchem.compound:1541501] synonym: "AC1LTW64" EXACT [pubchem.compound:1541501] synonym: "AC1Q2P5R" EXACT [pubchem.compound:1541501] synonym: "AKOS002170228" EXACT [pubchem.compound:1541501] synonym: "BDBM48044" EXACT [pubchem.compound:1541501] synonym: "D0Y1VB" EXACT [pubchem.compound:1541501] synonym: "GTPL3256" EXACT [pubchem.compound:1541501] synonym: "HMS3843E06" EXACT [pubchem.compound:1541501] synonym: "MCULE-6171593814" EXACT [pubchem.compound:1541501] synonym: "MLS002474500" EXACT [pubchem.compound:1541501] synonym: "MolPort-000-437-290" EXACT [pubchem.compound:1541501] synonym: "Oprea1_621562" EXACT [pubchem.compound:1541501] synonym: "SMR001398665" EXACT [pubchem.compound:1541501] synonym: "STK207844" EXACT [pubchem.compound:1541501] synonym: "VU0152099" EXACT [pubchem.compound:1541501] synonym: "VU0152099-1" EXACT [pubchem.compound:1541501] synonym: "ZINC1472126" EXACT [pubchem.compound:1541501] synonym: "cid_1541501" EXACT [pubchem.compound:1541501] [Term] id: CONSO:CONSO00204 name: VU0029767 namespace: chemical def: "selective M1(mAChR)-PAM. Chemical name: 2-(4-Ethoxyanilino)-N'-[(Z)-(2-oxonaphthalen-1-ylidene)methyl]acetohydrazide" [pubmed:24590577] xref: inchi:InChI=1S/C21H21N3O3/c1-2-27-17-10-8-16\(9-11-17\)22-14-21\(26\)24-23-13-19-18-6-4-3-5-15\(18\)7-12-20\(19\)25/h3-13\,22-23H\,2\,14H2\,1H3\,\(H\,24\,26\) xref: pubchem.compound:6758210 xref: smiles:CCOC1=CC=C\(C=C1\)NCC\(=O\)NNC=C2C\(=O\)C=CC3=CC=CC=C32 relationship: CONSO:author orcid:0000-0002-6117-4413 synonym: "2-(4-ethoxyanilino)-N'-[(E)-(2-oxonaphthalen-1-ylidene)methyl]acetohydrazide" EXACT [pubchem.compound:6758210] synonym: "2-[(4-ethoxyphenyl)amino]-N'-[(2-hydroxy-1-naphthyl)methylene]acetohydrazide (non-preferred name)" EXACT [pubchem.compound:6758210] synonym: "326001-01-8" EXACT [pubchem.compound:6758210] synonym: "AKOS028114549" EXACT [pubchem.compound:6758210] synonym: "AOB2484" EXACT [pubchem.compound:6758210] synonym: "BCP17383" EXACT [pubchem.compound:6758210] synonym: "D0L5AG" EXACT [pubchem.compound:6758210] synonym: "KS-000046FP" EXACT [pubchem.compound:6758210] synonym: "ZINC1204219" EXACT [pubchem.compound:6758210] synonym: "ZINC38534584" EXACT [pubchem.compound:6758210] [Term] id: CONSO:CONSO00205 name: VU0090157 namespace: chemical def: "selective M1(mAChR)-PAM. Chemical name: Cyclopentyl 3,4-dimethyl-6-(6-nitro-1,3-benzodioxol-5-yl)-2-oxo-1,6-dihydropyrimidine-5-carboxylate" [pubmed:24590577] xref: inchi:InChI=1S/C19H21N3O7/c1-10-16\(18\(23\)29-11-5-3-4-6-11\)17\(20-19\(24\)21\(10\)2\)12-7-14-15\(28-9-27-14\)8-13\(12\)22\(25\)26/h7-8\,11\,17H\,3-6\,9H2\,1-2H3\,\(H\,20\,24\) xref: pubchem.compound:2882724 xref: smiles:CC1=C\(C\(NC\(=O\)N1C\)C2=CC3=C\(C=C2\[N+\]\(=O\)\[O-\]\)OCO3\)C\(=O\)OC4CCCC4 relationship: CONSO:author orcid:0000-0002-6117-4413 synonym: "AC1MER3E" EXACT [pubchem.compound:2882724] synonym: "AKOS001633711" EXACT [pubchem.compound:2882724] synonym: "AKOS022078796" EXACT [pubchem.compound:2882724] synonym: "BIM-0042576.P001" EXACT [pubchem.compound:2882724] synonym: "CBMicro_042727" EXACT [pubchem.compound:2882724] synonym: "D0O6BD" EXACT [pubchem.compound:2882724] synonym: "EU-0038260" EXACT [pubchem.compound:2882724] synonym: "GTPL3259" EXACT [pubchem.compound:2882724] synonym: "MCULE-4339280714" EXACT [pubchem.compound:2882724] synonym: "MolPort-002-181-662" EXACT [pubchem.compound:2882724] synonym: "Oprea1_103541" EXACT [pubchem.compound:2882724] synonym: "SR-01000433423" EXACT [pubchem.compound:2882724] synonym: "SR-01000433423-1" EXACT [pubchem.compound:2882724] synonym: "STK079398" EXACT [pubchem.compound:2882724] synonym: "UNM000000551301" EXACT [pubchem.compound:2882724] synonym: "VU0090157" EXACT [pubchem.compound:2882724] synonym: "cyclopentyl 1,6-dimethyl-4-(6-nitro-1,3-benzodioxol-5-yl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate" EXACT [pubchem.compound:2882724] synonym: "cyclopentyl 1,6-dimethyl-4-(6-nitro-1,3-benzodioxol-5-yl)-2-oxo-3,4-dihydropyrimidine-5-carboxylate" EXACT [pubchem.compound:2882724] synonym: "cyclopentyl 1,6-dimethyl-4-(6-nitrobenzo[d][1,3]-dioxol-5-yl)-2-oxo-1,2,3,4 tetrahydropyrimidine-5-carboxylate" EXACT [pubchem.compound:2882724] synonym: "cyclopentyl 1,6-dimethyl-4-(6-nitrobenzo[d][1,3]-dioxol-5-yl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate" EXACT [pubchem.compound:2882724] synonym: "cyclopentyl 3,4-dimethyl-6-(6-nitro-1,3-benzodioxol-5-yl)-2-oxo-1,6-dihydropyrimidine-5-carboxylate" EXACT [pubchem.compound:2882724] [Term] id: CONSO:CONSO00206 name: VU0184670 namespace: chemical def: "M1(mAChR) allosteric agonists. Chemical name: Ethyl 4-(2-benzamidoethylamino)piperidine-1-carboxylate hydrochloride" [pubmed:24590577] xref: chembl:CHEMBL1535797 xref: inchi:InChI=1S/C17H25N3O3.ClH/c1-2-23-17\(22\)20-12-8-15\(9-13-20\)18-10-11-19-16\(21\)14-6-4-3-5-7-14;/h3-7\,15\,18H\,2\,8-13H2\,1H3\,\(H\,19\,21\);1H xref: pubchem.compound:25010774 xref: smiles:CCOC\(=O\)N1CCC\(CC1\)NCCNC\(=O\)C2=CC=CC=C2.Cl relationship: CONSO:author orcid:0000-0002-6117-4413 synonym: "1135241-95-0" EXACT [pubchem.compound:25010774] synonym: "CHEMBL1535797" EXACT [pubchem.compound:25010774] synonym: "MLS002279950" EXACT [pubchem.compound:25010774] synonym: "SMR001318088" EXACT [pubchem.compound:25010774] synonym: "VU0184670" EXACT [pubchem.compound:25010774] synonym: "ethyl 4-(2-benzamidoethylamino)piperidine-1-carboxylate hydrochloride" EXACT [pubchem.compound:25010774] [Term] id: CONSO:CONSO00207 name: 2-Bromohexadecanoic acid namespace: chemical def: "Inhibits Fyn localization in lipid rafts and subsequently inhibits the fyn-dependent Abeta redistribution and accumulation in lipid rafts, process linked with ADDL-induced cell death." [pubmed:18096814] xref: chebi:133152 xref: inchi:InChI=1S/C16H31BrO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15\(17\)16\(18\)19/h15H\,2-14H2\,1H3\,\(H\,18\,19\) xref: pubchem.compound:82145 xref: smiles:CCCCCCCCCCCCCCC\(C\(=O\)O\)Br relationship: CONSO:author orcid:0000-0001-9661-5277 synonym: ".alpha.-Bromopalmitic acid" EXACT [pubchem.compound:82145] synonym: "18263-25-7" EXACT [pubchem.compound:82145] synonym: "2-Bromohexadecanoic acid" EXACT [pubchem.compound:82145] synonym: "2-Bromohexadecanoic acid, >=99.0% (GC)" EXACT [pubchem.compound:82145] synonym: "2-Bromohexadecanoic acid, purum, >=97.0% (GC)" EXACT [pubchem.compound:82145] synonym: "2-Bromohexadecanoic acid, ~97%" EXACT [pubchem.compound:82145] synonym: "2-Bromopalmitate" EXACT [pubchem.compound:82145] synonym: "2-Bromopalmitic acid" EXACT [pubchem.compound:82145] synonym: "2-bromanylhexadecanoic acid" EXACT [pubchem.compound:82145] synonym: "2-bromo-hexadecanoic acid" EXACT [pubchem.compound:82145] synonym: "2-bromopalmitate, (+-)-isomer" EXACT [pubchem.compound:82145] synonym: "40305-76-8" EXACT [pubchem.compound:82145] synonym: "A812715" EXACT [pubchem.compound:82145] synonym: "AC1L32UD" EXACT [pubchem.compound:82145] synonym: "AC1Q2444" EXACT [pubchem.compound:82145] synonym: "ACM18263257" EXACT [pubchem.compound:82145] synonym: "ACMC-1C7OL" EXACT [pubchem.compound:82145] synonym: "AKOS003404931" EXACT [pubchem.compound:82145] synonym: "AKOS017343270" EXACT [pubchem.compound:82145] synonym: "BDBM50148454" EXACT [pubchem.compound:82145] synonym: "C-20189" EXACT [pubchem.compound:82145] synonym: "C16H31BrO2" EXACT [pubchem.compound:82145] synonym: "CAS-18263-25-7" EXACT [pubchem.compound:82145] synonym: "CC-09685" EXACT [pubchem.compound:82145] synonym: "CHEBI:133152" EXACT [pubchem.compound:82145] synonym: "CHEMBL118417" EXACT [pubchem.compound:82145] synonym: "CTK4D8252" EXACT [pubchem.compound:82145] synonym: "DB-044471" EXACT [pubchem.compound:82145] synonym: "DPRAYRYQQAXQPE-UHFFFAOYSA-N" EXACT [pubchem.compound:82145] synonym: "DSSTox_CID_17734" EXACT [pubchem.compound:82145] synonym: "DSSTox_GSID_37734" EXACT [pubchem.compound:82145] synonym: "DSSTox_RID_79368" EXACT [pubchem.compound:82145] synonym: "DTXSID0037734" EXACT [pubchem.compound:82145] synonym: "EINECS 242-137-0" EXACT [pubchem.compound:82145] synonym: "FT-0611564" EXACT [pubchem.compound:82145] synonym: "Hexadecanoic acid, 2-bromo-" EXACT [pubchem.compound:82145] synonym: "Hexadecanoic acid,2-bromo-" EXACT [pubchem.compound:82145] synonym: "I04-8986" EXACT [pubchem.compound:82145] synonym: "J-011689" EXACT [pubchem.compound:82145] synonym: "KB-68336" EXACT [pubchem.compound:82145] synonym: "L213" EXACT [pubchem.compound:82145] synonym: "LMFA01090011" EXACT [pubchem.compound:82145] synonym: "LS-174823" EXACT [pubchem.compound:82145] synonym: "MCULE-7613431163" EXACT [pubchem.compound:82145] synonym: "MFCD00004215" EXACT [pubchem.compound:82145] synonym: "MolPort-001-759-724" EXACT [pubchem.compound:82145] synonym: "NCGC00164251-01" EXACT [pubchem.compound:82145] synonym: "NCGC00164251-02" EXACT [pubchem.compound:82145] synonym: "NCGC00254935-01" EXACT [pubchem.compound:82145] synonym: "NCIOpen2_007723" EXACT [pubchem.compound:82145] synonym: "NSC 58378" EXACT [pubchem.compound:82145] synonym: "NSC-58378" EXACT [pubchem.compound:82145] synonym: "NSC58378" EXACT [pubchem.compound:82145] synonym: "OR10833" EXACT [pubchem.compound:82145] synonym: "SBB071635" EXACT [pubchem.compound:82145] synonym: "SCHEMBL97565" EXACT [pubchem.compound:82145] synonym: "ST45026694" EXACT [pubchem.compound:82145] synonym: "TC-170832" EXACT [pubchem.compound:82145] synonym: "TRA0083226" EXACT [pubchem.compound:82145] synonym: "Tox21_301033" EXACT [pubchem.compound:82145] synonym: "VZ24096" EXACT [pubchem.compound:82145] synonym: "ZX-AT022731" EXACT [pubchem.compound:82145] synonym: "alpha-Bromopalmitic acid" EXACT [pubchem.compound:82145] synonym: "bromohexadecanoic acid" EXACT [pubchem.compound:82145] [Term] id: CONSO:CONSO00208 name: 20 S Proteasome namespace: protein_complex def: "The catalytic core of the 26 S proteasome system, responsible for tau degradation" [pubmed:17954934, pubmed:19145068] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00209 name: 3-3 dityrosine cross-linking def: "An oxidation product consisting of covalent ortho-ortho coupling between two tyrosine residues formed as a conseguence to UV irradiation, gamma-irradiation, aging, exposure to oxygen free radicals, nitrogen dioxide, peroxynitrite, and lipid hydroperoxides. ROS catalyzed by Cu ions are involved in the generation of these cross-links in amyloid beta oligomers to which they provide stability. Also involved in the stabilization of tau PHF. A potential biomarker of oxidative stress in AD." [pubmed:16566606, pubmed:24351276] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00210 name: Braak_Stage I def: "A disease propagation and progression model, composed of six stages of increasing pathological severity determined by the location of the tangle-bearing neurons and the amplitude of the pathophysiological changes. Transentorhinal stages I-II: correspond to clinically silent cases of very mildly affected subjects, showing no cognitive impairment. NFT are slowly and gradually developping." [pubmed:28176663, pubmed:7566337] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00211 name: Braak_Stage II def: "A disease propagation and progression model, composed of six stages of increasing pathological severity determined by the location of the tangle-bearing neurons and the amplitude of the pathophysiological changes. Transentorhinal stages I-II: correspond to clinically silent cases of very mildly affected subjects, showing no cognitive impairment. NFT are slowly and gradually developping." [pubmed:28176663, pubmed:7566337] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00212 name: Braak_Stage III def: "A disease propagation and progression model, composed of six stages of increasing pathological severity determined by the location of the tangle-bearing neurons and the amplitude of the pathophysiological changes.Limbic stages III-IV designate an incipient Alzheimer's disease, since due to the lack of neocortical destruction, stages III and IV do not meet the currently used criteria for neuropathologic diagnosis of AD. Stage III is characterised by the destruction of the external principal stratum of the entorhinal laminae presenting considerable amounts of NFT and neuropil threads." [pubmed:7566337] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00213 name: Braak_Stage IV def: "A disease propagation and progression model, composed of six stages of increasing pathological severity determined by the location of the tangle-bearing neurons and the amplitude of the pathophysiological changes.Limbic stages III-IV designate an incipient Alzheimer's disease, since due to the lack of neocortical destruction, stages III and IV do not meet the currently used criteria for neuropathologic diagnosis of AD. Stage IV is characterised by the destruction of the internal principal stratum of the entorhinal laminae presenting considerable amounts of NFT and neuropil threads. The destruction of entorhinal cellular layers interferes with the normal transfer of information between neocortex and hippocampus, manifesting as cognitive impairment and subtle personality changes." [pubmed:7566337] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00214 name: Braak_Stage V def: "A disease propagation and progression model, composed of six stages of increasing pathological severity determined by the location of the tangle-bearing neurons and the amplitude of the pathophysiological changes.neocortical stages V-VI correspond to fully developed Alzheimer's disease. These stages are characterized by large numbers of NFTs in all sections of cerebral cortex and present neocortical damage thus contributing to the development of the conventional neuropathological criteria for the clinical diagnosis of AD." [pubmed:28176663, pubmed:7566337] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00215 name: Braak_Stage VI def: "A disease propagation and progression model, composed of six stages of increasing pathological severity determined by the location of the tangle-bearing neurons and the amplitude of the pathophysiological changes.neocortical stages V-VI correspond to fully developed Alzheimer's disease. These stages are characterized by large numbers of NFTs in all sections of cerebral cortex and present neocortical damage thus contributing to the development of the conventional neuropathological criteria for the clinical diagnosis of AD." [pubmed:7566337] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00216 name: CagA peptide namespace: peptide def: "A peptide with sequence:GFPLKRHDGVDDLSKVG, originally synthesized by Helicobacter Pylori acting as a specific MARK kinase inhibitor, decreasing tau phosphorylation" [pubmed:23666762, pubmed:19966800] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00217 name: MARK4 isoform 2 (688 aa) namespace: isoform def: "Shortest isoform of Microtubule affinity regulating kinase 4 (MARK4) derived from alternatvie splicing. It is upregulated during the early stages of neuron differentiation." [pubmed:16973293] xref: uniprot.isoform:Q96L34-2 relationship: CONSO:has_reference_protein uniprot:Q96L34 relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00218 name: NP_001387.2:p.Arg205del namespace: protein_variant def: "Loss of function mutant of DYRK1A isoform 1" [pubmed:28167836] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00219 name: NP_001387.2:p.Glu239del namespace: protein_variant def: "Loss of function mutant of DYRK1A isoform 1" [pubmed:28167837] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00220 name: PrP106-126 namespace: protein_fragment def: "Prion protein fragment 106-126. This peptide increases membrane microviscosity, intracellular Ca2+ concentration and cell migration in circulating leucocytes, and oxygen production in monocytes and neutrophils. It also induces apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in the GH3 cell lines. PrP (106–126) stimulates leucocyte migration in a dose-dependent manner. Inhibits tau phosphorylaton at Ser262. Seq = KTNMKHMAGAAAAGAVVGGLG" [pubmed:22692785] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00221 name: Purkinje cell layer of cerebellar cortex namespace: anatomy def: "The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [pubmed:29221819] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00222 name: Tau antibody, AGG5759 namespace: antibody def: "Tau antibody with specificity for pSer262" [pubmed:23666762] is_a: CONSO:CONSO00307 ! Tau antibody relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00223 name: Tau antibody, Tau-13 namespace: antibody def: "Tau murine monoclonal antibody with specificity for pSer262" [pubmed:23666762] is_a: CONSO:CONSO00307 ! Tau antibody relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00224 name: Tau epitope, 12E8 namespace: epitope def: "Tau epitope consisting of pSer262 and pSer356" [pubmed:22156579] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00225 name: Tau epitope, AT180 namespace: epitope def: "Tau epitope consisting of pThr231" [pubmed:22833681] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00226 name: Tau epitope, AT8 namespace: epitope def: "Tau epitope consisting of pSer202, pThr205, pSer208, pSer199" [pubmed:18239272] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00227 name: Tau epitope, CP13 namespace: epitope def: "Tau epitope consisting of pSer202" [pubmed:25331948] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00228 name: Tau epitope, PHF1 namespace: epitope def: "Tau epitope consisting of pSer396, pSer404" [pubmed:22156579] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00229 name: dystrophic neurite def: "Dysfunctional axons and terminals that accumulate the β-site amyloid precursor protein (APP) cleaving enzyme (BACE1) required for Aβ generation." [pubmed:28877763] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00230 name: granular layer of cerebellar cortex namespace: anatomy def: "The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer" [pubmed:29221819] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00231 name: molecular layer of cerebellar cortex namespace: anatomy def: "The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [pubmed:29221819] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00232 name: Kalirin 7 namespace: isoform def: "Isoform of KALRN protein" [pubmed:27796283] relationship: CONSO:has_reference_protein uniprot:O60229 relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00233 name: 4R tauopathy namespace: pathology def: "Tauopathies characterized by a relatively higher presence of the 4R tau isoforms, such as Alzheimers Disease and Corticobasal Degeneration" [pubmed:21427723] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00234 name: ACY-1215 namespace: chemical def: "Ricolinostat is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity. Ricolinostat selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation. This leads to an accumulation of unfolded and misfolded ubiquitinated proteins and may eventually induce cancer cell apoptosis, and inhibition of cancer cell growth. HDAC6, a class II HDAC deacetylase located in the cytoplasm, appears to play a key role in the formation and activation of the aggresomes needed for degradation of misfolded proteins. Compared to non-selective HDAC inhibitor, ACY-1215 is able to reduce the toxic effects on normal, healthy cells." [pubmed:24844691] xref: cas:1316214-52-4 xref: chebi:95073 xref: drugbank:DB12376 xref: inchi:InChI=1S/C24H27N5O3/c30-22\(28-32\)15-9-1-2-10-16-25-23\(31\)19-17-26-24\(27-18-19\)29\(20-11-5-3-6-12-20\)21-13-7-4-8-14-21/h3-8\,11-14\,17-18\,32H\,1-2\,9-10\,15-16H2\,\(H\,25\,31\)\(H\,28\,30\) xref: mesh:C572255 xref: pubchem.compound:53340666 xref: smiles:C1=CC=C\(C=C1\)N\(C2=CC=CC=C2\)C3=NC=C\(C=N3\)C\(=O\)NCCCCCCC\(=O\)NO relationship: CONSO:author orcid:0000-0001-9661-5277 synonym: "1316214-52-4" EXACT [pubchem.compound:53340666] synonym: "2-(Diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide" EXACT [pubchem.compound:53340666] synonym: "2-(Diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide" EXACT [pubchem.compound:53340666] synonym: "2-(diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]pyrimidine-5-carboxamide" EXACT [pubchem.compound:53340666] synonym: "5-Pyrimidinecarboxamide, 2-(diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)-" EXACT [pubchem.compound:53340666] synonym: "5-Pyrimidinecarboxamide, 2-(diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-" EXACT [pubchem.compound:53340666] synonym: "7-{[2-(DIPHENYLAMINO)PYRIMIDIN-5-YL]FORMAMIDO}-N-HYDROXYHEPTANAMIDE" EXACT [pubchem.compound:53340666] synonym: "A11940" EXACT [pubchem.compound:53340666] synonym: "AB0032517" EXACT [pubchem.compound:53340666] synonym: "AC-30258" EXACT [pubchem.compound:53340666] synonym: "ACN-030031" EXACT [pubchem.compound:53340666] synonym: "ACY-1215" EXACT [pubchem.compound:53340666] synonym: "ACY-63" EXACT [pubchem.compound:53340666] synonym: "ACY1215" EXACT [pubchem.compound:53340666] synonym: "AH4" EXACT [pubchem.compound:53340666] synonym: "AJ-128539" EXACT [pubchem.compound:53340666] synonym: "AK151416" EXACT [pubchem.compound:53340666] synonym: "AKOS024259260" EXACT [pubchem.compound:53340666] synonym: "AX8288032" EXACT [pubchem.compound:53340666] synonym: "BC600387" EXACT [pubchem.compound:53340666] synonym: "BCP06028" EXACT [pubchem.compound:53340666] synonym: "BDBM50439674" EXACT [pubchem.compound:53340666] synonym: "CHEBI:95073" EXACT [pubchem.compound:53340666] synonym: "CHEMBL2364628" EXACT [pubchem.compound:53340666] synonym: "CS-0965" EXACT [pubchem.compound:53340666] synonym: "D0TP9M" EXACT [pubchem.compound:53340666] synonym: "D10661" EXACT [pubchem.compound:53340666] synonym: "DB12376" EXACT [pubchem.compound:53340666] synonym: "DTXSID40157148" EXACT [pubchem.compound:53340666] synonym: "EX-A139" EXACT [pubchem.compound:53340666] synonym: "GTPL7010" EXACT [pubchem.compound:53340666] synonym: "HMS3653F17" EXACT [pubchem.compound:53340666] synonym: "HY-16026" EXACT [pubchem.compound:53340666] synonym: "J-690127" EXACT [pubchem.compound:53340666] synonym: "KB-74507" EXACT [pubchem.compound:53340666] synonym: "KS-00000SAV" EXACT [pubchem.compound:53340666] synonym: "MFCD22666356" EXACT [pubchem.compound:53340666] synonym: "MLS006011181" EXACT [pubchem.compound:53340666] synonym: "MolPort-028-600-031" EXACT [pubchem.compound:53340666] synonym: "N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)pyrimidine-5-carboxamide" EXACT [pubchem.compound:53340666] synonym: "NCGC00345802-01" EXACT [pubchem.compound:53340666] synonym: "NCGC00345802-05" EXACT [pubchem.compound:53340666] synonym: "Ricolinostat" EXACT [pubchem.compound:53340666] synonym: "Ricolinostat (ACY-1215)" EXACT [pubchem.compound:53340666] synonym: "Ricolinostat (USAN/INN)" EXACT [pubchem.compound:53340666] synonym: "Ricolinostat [USAN:INN]" EXACT [pubchem.compound:53340666] synonym: "Rocilinostat" EXACT [pubchem.compound:53340666] synonym: "Rocilinostat (ACY-1215)" EXACT [pubchem.compound:53340666] synonym: "SB17054" EXACT [pubchem.compound:53340666] synonym: "SCHEMBL574580" EXACT [pubchem.compound:53340666] synonym: "SMR004702950" EXACT [pubchem.compound:53340666] synonym: "ST24039648" EXACT [pubchem.compound:53340666] synonym: "SW219836-1" EXACT [pubchem.compound:53340666] synonym: "UNII-WKT909C62B" EXACT [pubchem.compound:53340666] synonym: "US8609678, 2-(diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide [26]" EXACT [pubchem.compound:53340666] synonym: "W-5979" EXACT [pubchem.compound:53340666] synonym: "WKT909C62B" EXACT [pubchem.compound:53340666] synonym: "X5832" EXACT [pubchem.compound:53340666] synonym: "ZINC89630354" EXACT [pubchem.compound:53340666] synonym: "rocilinostat-acy-1215" EXACT [pubchem.compound:53340666] synonym: "s8001" EXACT [pubchem.compound:53340666] [Term] id: CONSO:CONSO00235 name: APOE e3 namespace: genetic_variant def: "Interacts with tubulin binding repeat 1" [pubmed:26751493] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00236 name: BAY61-3606 namespace: chemical def: "A cell-permeable imidazopyrimidine compound that acts a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC50 = 10 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src even at concentrations as high as 4.7 µM. Shown to inhibit Syk-mediated cellular functions in vitro and exhibit good oral bioavailability and in vivo effacacy in the treatment of various allgery and asthma conditions in rat models. Indirect inhibitory effect on GSK3B activity" [pubmed:25331948] xref: cas:732983-37-8 xref: chebi:91426 xref: inchi:InChI=1S/C20H18N6O3/c1-28-15-6-5-12\(10-16\(15\)29-2\)14-11-17-22-8-9-26\(17\)20\(24-14\)25-19-13\(18\(21\)27\)4-3-7-23-19/h3-11H\,1-2H3\,\(H2\,21\,27\)\(H\,23\,24\,25\) xref: mesh:C477642 xref: pubchem.compound:10200390 xref: smiles:COC1=C\(C=C\(C=C1\)C2=CC3=NC=CN3C\(=N2\)NC4=C\(C=CC=N4\)C\(=O\)N\)OC xref: wikidata:Q27163275 relationship: CONSO:author orcid:0000-0001-9661-5277 synonym: "2-((7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl)amino)nicotinamide" EXACT [pubchem.compound:10200390] synonym: "2-(7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-ylamino)nicotinamide hydrochloride" EXACT [pubchem.compound:10200390] synonym: "2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide" EXACT [pubchem.compound:10200390] synonym: "2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidine-5-yl]amino]-3-pyridinecarboxamide" EXACT [pubchem.compound:10200390] synonym: "2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide" EXACT [pubchem.compound:10200390] synonym: "3-Pyridinecarboxamide, 2-((7-(3,4-dimethoxyphenyl)imidazo(1,2-C)pyrimidin-5-yl)amino)-" EXACT [pubchem.compound:10200390] synonym: "61G8S0H9KX" EXACT [pubchem.compound:10200390] synonym: "732983-37-8" EXACT [pubchem.compound:10200390] synonym: "A11320" EXACT [pubchem.compound:10200390] synonym: "AC-29888" EXACT [pubchem.compound:10200390] synonym: "ACN-053214" EXACT [pubchem.compound:10200390] synonym: "AKOS030526888" EXACT [pubchem.compound:10200390] synonym: "BAY 61-3606" EXACT [pubchem.compound:10200390] synonym: "BAY 61-3606 HCl" EXACT [pubchem.compound:10200390] synonym: "BAY-61-360" EXACT [pubchem.compound:10200390] synonym: "BAY-61-3606 free base" EXACT [pubchem.compound:10200390] synonym: "BAY-613606" EXACT [pubchem.compound:10200390] synonym: "BAY61-3606" EXACT [pubchem.compound:10200390] synonym: "BCP08946" EXACT [pubchem.compound:10200390] synonym: "BDBM50325991" EXACT [pubchem.compound:10200390] synonym: "BRD-K53281329-001-01-9" EXACT [pubchem.compound:10200390] synonym: "CCG-102604" EXACT [pubchem.compound:10200390] synonym: "CHEBI:91426" EXACT [pubchem.compound:10200390] synonym: "CHEMBL1190711" EXACT [pubchem.compound:10200390] synonym: "CHEMBL1242100" EXACT [pubchem.compound:10200390] synonym: "CS-0235" EXACT [pubchem.compound:10200390] synonym: "EX-A1437" EXACT [pubchem.compound:10200390] synonym: "GTPL9693" EXACT [pubchem.compound:10200390] synonym: "HY-76474" EXACT [pubchem.compound:10200390] synonym: "J-507625" EXACT [pubchem.compound:10200390] synonym: "KB-74859" EXACT [pubchem.compound:10200390] synonym: "Kinome_3125" EXACT [pubchem.compound:10200390] synonym: "NCGC00346945-01" EXACT [pubchem.compound:10200390] synonym: "NCGC00346945-06" EXACT [pubchem.compound:10200390] synonym: "RL04784" EXACT [pubchem.compound:10200390] synonym: "SCHEMBL373774" EXACT [pubchem.compound:10200390] synonym: "Syk inhibitor IV" EXACT [pubchem.compound:10200390] synonym: "UNII-61G8S0H9KX" EXACT [pubchem.compound:10200390] synonym: "ZINC3817793" EXACT [pubchem.compound:10200390] synonym: "cc-526" EXACT [pubchem.compound:10200390] [Term] id: CONSO:CONSO00237 name: Biphenyl-4-yl-acrylohydroxamoc acids namespace: chemical_class def: "Chemical compund group acting as inhibitors of HDAC family proteins." [pubmed:26890116] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00238 name: Brodmann (1909) area 36 namespace: anatomy def: "Ectorhinal area 36 is a subdivision of the cytoarchitecturally defined temporal region of cerebral cortex. With its medial boundary corresponding approximately to the rhinal sulcus it is located primarily in the fusiform gyrus. Cytoarchitecturally it is bounded laterally and caudally by the inferior temporal area 20, medially by the perirhinal area 35 and rostrally by the temporopolar area 38 (H) (Brodmann-1909). Together with Brodmann area 35, it comprises the perirhinal cortex." [pubmed:23407988] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00239 name: C-30-27 namespace: chemical def: "PCAF and NFkappaB inhibitor, showed anti-inflammatory properties and improved cognition" [pubmed:25672970] xref: inchi:InChI=1S/C20H26ClN3O3/c1-25-19-13-16\(14-22-6-7-24-8-10-26-11-9-24\)12-18\(21\)20\(19\)27-15-17-4-2-3-5-23-17/h2-5\,12-13\,22H\,6-11\,14-15H2\,1H3 xref: smiles:C1COCCN1CCNCC2=CC\(=C\(C\(=C2\)Cl\)OCC3=CC=CC=N3\)OC relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00240 name: C646 namespace: chemical def: "Inhibitor of EP300 acetylase" [pubmed:20869593] xref: inchi:InChI=1S/C24H19N3O6/c1-13-10-20\(21\(27\(31\)32\)11-14\(13\)2\)22-9-8-18\(33-22\)12-19-15\(3\)25-26\(23\(19\)28\)17-6-4-16\(5-7-17\)24\(29\)30/h4-12H\,1-3H3\,\(H\,29\,30\)/b19-12+ xref: pubchem.compound:1285940 xref: smiles:CC1=C\(C=C\(C\(=C1\)C2=CC=C\(O2\)C=C3C\(=NN\(C3=O\)C4=CC=C\(C=C4\)C\(=O\)O\)C\)\[N+\]\(=O\)\[O-\]\)C relationship: CONSO:author orcid:0000-0001-9661-5277 synonym: "(E)-4-(4-((5-(4,5-diMethyl-2-nitrophenyl)furan-2-yl)Methylene)-3-Methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid" EXACT [pubchem.compound:1285940] synonym: "328968-36-1" EXACT [pubchem.compound:1285940] synonym: "4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid" EXACT [pubchem.compound:1285940] synonym: "4-[(4E)-4-[[5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid" EXACT [pubchem.compound:1285940] synonym: "4-[(4E)-4-{[5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl]methylidene}-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid" EXACT [pubchem.compound:1285940] synonym: "AC1LPE4S" EXACT [pubchem.compound:1285940] synonym: "AKOS005418912" EXACT [pubchem.compound:1285940] synonym: "AOB5549" EXACT [pubchem.compound:1285940] synonym: "BC600370" EXACT [pubchem.compound:1285940] synonym: "BRD-K68548958-001-01-2" EXACT [pubchem.compound:1285940] synonym: "C 646" EXACT [pubchem.compound:1285940] synonym: "C-646" EXACT [pubchem.compound:1285940] synonym: "C646" EXACT [pubchem.compound:1285940] synonym: "CHEMBL3734823" EXACT [pubchem.compound:1285940] synonym: "CS-3529" EXACT [pubchem.compound:1285940] synonym: "EX-A1063" EXACT [pubchem.compound:1285940] synonym: "HY-13823" EXACT [pubchem.compound:1285940] synonym: "KB-145969" EXACT [pubchem.compound:1285940] synonym: "MolPort-002-976-806" EXACT [pubchem.compound:1285940] synonym: "SCHEMBL14991291" EXACT [pubchem.compound:1285940] synonym: "STK219801" EXACT [pubchem.compound:1285940] synonym: "ZINC13838357" EXACT [pubchem.compound:1285940] [Term] id: CONSO:CONSO00241 name: CA1 field of hippocampus namespace: anatomy def: "Part of hippocampus proper bounded by CA2 and the subiculum, characterized by pyramidal neurons that receive projections from pyramidal neurons of CA3 via the Schaffer collaterals." [pubmed:23407988] xref: mesh:D056547 relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00242 name: CA2 field of hippocampus namespace: anatomy def: "Part of hippocampus proper bounded by areas CA3 and CA1, characterized by a narrow layer of large pyramidal cells, similar in size to CA3 pyramidal cells, but which lack the mossy fiber input from the dentate gyrus" [pubmed:23407988] xref: mesh:D056651 relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00243 name: CA3 field of hippocampus namespace: anatomy def: "Part of hippocampus proper bounded by the hilus of the dentate gyrus and area CA2, characterized by large pyramidal cells and a dense projection from dentate gyrus granule cell mossy fibers." [pubmed:23407988] xref: mesh:D056654 relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00244 name: CA4 field of hippocampus namespace: anatomy def: "The last of four regions in the cornu ammonis of the hippocampus and is also part of the hilus of the dentate gyrus. This area contains mostly mossy cells that receive inputs from the dentate gyrus and pyramidal cells in the CA3 region and also projects back to the dentate gyrus." [pubmed:23407988] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00245 name: CGP3466B namespace: chemical def: "Inhibitor of GAPDH nitrosylation, abrogated Abeta induced tau acetylation and subsequent pathological impairments related to AD" [pubmed:29559585] xref: chebi:35364 xref: chebi:41778 xref: chembl:CHEMBL1232111 xref: chembl:CHEMBL3734823 xref: drugbank:DB12879 xref: inchi:InChI=1S/C19H17NO/c1-3-12-20\(2\)14-16-13-15-8-4-6-10-18\(15\)21-19-11-7-5-9-17\(16\)19/h1\,4-11\,13H\,12\,14H2\,2H3 xref: pubchem.compound:6419718 xref: smiles:CN\(CC#C\)CC1=CC2=CC=CC=C2OC3=CC=CC=C31 relationship: CONSO:author orcid:0000-0001-9661-5277 synonym: "(Dibenzo(b,f)oxepin-5-ylmethyl)(methyl)prop-2-yn-1-amine" EXACT [pubchem.compound:6419718] synonym: "181296-84-4" EXACT [pubchem.compound:6419718] synonym: "5V14HD0N4Q" EXACT [pubchem.compound:6419718] synonym: "634202-78-1" EXACT [pubchem.compound:6419718] synonym: "AC1O4WBX" EXACT [pubchem.compound:6419718] synonym: "CGP 3466" EXACT [pubchem.compound:6419718] synonym: "CGP-3466" EXACT [pubchem.compound:6419718] synonym: "CGP-3499B" EXACT [pubchem.compound:6419718] synonym: "CHEBI:41778" EXACT [pubchem.compound:6419718] synonym: "CHEMBL1232111" EXACT [pubchem.compound:6419718] synonym: "D06KSV" EXACT [pubchem.compound:6419718] synonym: "DB12879" EXACT [pubchem.compound:6419718] synonym: "DTXSID10171098" EXACT [pubchem.compound:6419718] synonym: "Dibenzo(b,f)oxepin-10-ylmethyl-methyl-prop-2-ynylamine" EXACT [pubchem.compound:6419718] synonym: "N-(DIBENZO[B,F]OXEPIN-10-YLMETHYL)-N-METHYL-N-PROP-2-YNYLAMINE" EXACT [pubchem.compound:6419718] synonym: "N-(benzo[b][1]benzoxepin-5-ylmethyl)-N-methylprop-2-yn-1-amine" EXACT [pubchem.compound:6419718] synonym: "N-(dibenzo[b,f]oxepin-10-ylmethyl)-N-methylprop-2-yn-1-amine" EXACT [pubchem.compound:6419718] synonym: "NCGC00346431-01" EXACT [pubchem.compound:6419718] synonym: "Neuroprotectant, Novartis" EXACT [pubchem.compound:6419718] synonym: "Neuroprotectant, Santhera" EXACT [pubchem.compound:6419718] synonym: "Nootropic agent, Novartis" EXACT [pubchem.compound:6419718] synonym: "Nootropicagent, Santhera" EXACT [pubchem.compound:6419718] synonym: "Omigapil" EXACT [pubchem.compound:6419718] synonym: "Omigapil [INN]" EXACT [pubchem.compound:6419718] synonym: "Omigapil)" EXACT [pubchem.compound:6419718] synonym: "QLMMOGWZCFQAPU-UHFFFAOYSA-N" EXACT [pubchem.compound:6419718] synonym: "SCHEMBL333032" EXACT [pubchem.compound:6419718] synonym: "SNT-317" EXACT [pubchem.compound:6419718] synonym: "TCH-346" EXACT [pubchem.compound:6419718] synonym: "TCH-346B" EXACT [pubchem.compound:6419718] synonym: "TCH346" EXACT [pubchem.compound:6419718] synonym: "Tch 346" EXACT [pubchem.compound:6419718] synonym: "UNII-5V14HD0N4Q" EXACT [pubchem.compound:6419718] synonym: "ZINC33943510" EXACT [pubchem.compound:6419718] synonym: "dibenz[b,f]oxepin-10-ylmethyl-N-methyl-N-prop-2-ynylamine" EXACT [pubchem.compound:6419718] synonym: "dibenzo-(b,f)oxepin-10-ylmethyl-methyl-prop-2-ynyl-amine" EXACT [pubchem.compound:6419718] [Term] id: CONSO:CONSO00246 name: CM-414 namespace: chemical def: "A dual inhibitor of PDE5 and HDACs, chronic treatment of Tg2576 mice, a well characterized AD mouse model, showed decreased Ab and Tau phsophorylation and inhibition of GSK3B activity." [pubmed:27550730] xref: cas:4432-44-4 xref: inchi:InChI=1S/C8H13NO3/c1-7\(8\(10\)11\)6-9-2-4-12-5-3-9/h1-6H2\,\(H\,10\,11\) xref: pubchem.compound:10397232 xref: smiles:C=C\(CN1CCOCC1\)C\(=O\)O relationship: CONSO:author orcid:0000-0001-9661-5277 synonym: "2-(4-morpholinylmethyl)-2-propenoic acid" EXACT [pubchem.compound:10397232] synonym: "2-(Morpholinomethyl)acrylic acid" EXACT [pubchem.compound:10397232] synonym: "2-(Morpholinomethyl)propenoic acid" EXACT [pubchem.compound:10397232] synonym: "2-(morpholin-4-ylmethyl)prop-2-enoic Acid" EXACT [pubchem.compound:10397232] synonym: "2-MORPHOLIN-4-YLMETHYL-ACRYLIC ACID" EXACT [pubchem.compound:10397232] synonym: "2-Morpholin4-ylmethyl-acrylic acid" EXACT [pubchem.compound:10397232] synonym: "2-[(morpholin-4-yl)methyl]prop-2-enoic acid" EXACT [pubchem.compound:10397232] synonym: "2-morpholin-4-ylmethyl-2-propenoic acid" EXACT [pubchem.compound:10397232] synonym: "2-morpholin-4ylmethyl-2-propenoic acid" EXACT [pubchem.compound:10397232] synonym: "4-Morpholinepropanoicacid, a-methylene-" EXACT [pubchem.compound:10397232] synonym: "4432-44-4" EXACT [pubchem.compound:10397232] synonym: "4868AH" EXACT [pubchem.compound:10397232] synonym: "A826542" EXACT [pubchem.compound:10397232] synonym: "AB0085720" EXACT [pubchem.compound:10397232] synonym: "AB1552" EXACT [pubchem.compound:10397232] synonym: "AJ-96850" EXACT [pubchem.compound:10397232] synonym: "AKOS010054622" EXACT [pubchem.compound:10397232] synonym: "CM-414" EXACT [pubchem.compound:10397232] synonym: "CTK4I8112" EXACT [pubchem.compound:10397232] synonym: "DB-070534" EXACT [pubchem.compound:10397232] synonym: "DTXSID30439182" EXACT [pubchem.compound:10397232] synonym: "F9995-2550" EXACT [pubchem.compound:10397232] synonym: "FT-0718529" EXACT [pubchem.compound:10397232] synonym: "IGZSSKAOSOCVPH-UHFFFAOYSA-N" EXACT [pubchem.compound:10397232] synonym: "K-8942" EXACT [pubchem.compound:10397232] synonym: "KB-106928" EXACT [pubchem.compound:10397232] synonym: "MCULE-2720405682" EXACT [pubchem.compound:10397232] synonym: "MFCD06208438" EXACT [pubchem.compound:10397232] synonym: "MolPort-019-997-392" EXACT [pubchem.compound:10397232] synonym: "SCHEMBL793684" EXACT [pubchem.compound:10397232] synonym: "ZINC38760485" EXACT [pubchem.compound:10397232] [Term] id: CONSO:CONSO00247 name: DAPK, basic loop (BL) motif namespace: motif def: "A structural motif of DAPK (Death-Associated Protein Kinase) positively regulating the kinase activity." [pubmed:27133022] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00248 name: Histone H3 namespace: protein def: "One of the five main histone proteins of chromatin structure, acetylation at Lys 9 was positively linked with the transcriptional activation of various genes involved in neuro-regeneration following peripheral axonal injury, among which BDNF." [pubmed:24686445] xref: fplx:Histone_H3 relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00249 name: ID-8 namespace: chemical def: "Inhibitor of GSK3Beta and DYRK1 kinases" [pubmed:28884684] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00250 name: LDN-193594 namespace: chemical def: "A synthetic derviative of 2,4-diaminothiazole serving as an inhibitor of CDK5 kinase acitivty and of tau PHF1 epitope phosphorylation" [pubmed:23737518] xref: chembl:CHEMBL1761791 xref: inchi:InChI=1S/C15H11FN4OS/c16-11-6-2-1-5-10\(11\)12\(21\)13-14\(17\)20-15\(22-13\)19-9-4-3-7-18-8-9/h1-8H\,17H2\,\(H\,19\,20\) xref: pubchem.compound:54581340 xref: smiles:C1=CC=C\(C\(=C1\)C\(=O\)C2=C\(N=C\(S2\)NC3=CN=CC=C3\)N\)F is_a: CONSO:CONSO00276 ! diaminothiazole relationship: CONSO:author orcid:0000-0001-9661-5277 synonym: "(4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(2-fluorophenyl)methanone" EXACT [pubchem.compound:54581340] synonym: "1289638-15-8" EXACT [pubchem.compound:54581340] synonym: "BDBM50340902" EXACT [pubchem.compound:54581340] synonym: "CHEMBL1761791" EXACT [pubchem.compound:54581340] synonym: "KB-274259" EXACT [pubchem.compound:54581340] synonym: "NSC-747885" EXACT [pubchem.compound:54581340] synonym: "NSC747885" EXACT [pubchem.compound:54581340] synonym: "XHJMMMPXTUEBMQ-UHFFFAOYSA-N" EXACT [pubchem.compound:54581340] synonym: "ZINC71317068" EXACT [pubchem.compound:54581340] synonym: "ldn-193594" EXACT [pubchem.compound:54581340] [Term] id: CONSO:CONSO00251 name: LDN-193665 namespace: chemical def: "A synthetic derviative of 2,4-diaminothiazole with a lesser powerful inhibitory effect on CDK5, but a potent inhibitor of Gsk3b" [pubmed:23737518] xref: cas:1289638-16-9 xref: inchi:\WInChI=1S/C15H11FN4OS/c16-10-4-1-3-9\(7-10\)12\(21\)13-14\(17\)20-15\(22-13\)19-11-5-2-6-18-8-11/h1-8H\,17H2\,\(H\,19\,20\) xref: smiles:FC1=CC=CC\(C\(C2=C\(N\)N=C\(NC3=CN=CC=C3\)S2\)=O\)=C1 is_a: CONSO:CONSO00277 ! diaminothiazole relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00252 name: LDN-213843 namespace: chemical def: "Small molecule of the diaminothiazole class, acting as inhibitor of CDK5 and GSK3Beta kinases" [pubmed:23737518] xref: inchi:InChI=1S/C19H19FN6OS/c20-14-4-2-1-3-13\(14\)16\(27\)17-18\(21\)25-19\(28-17\)24-12-5-6-15\(23-11-12\)26-9-7-22-8-10-26/h1-6\,11\,22H\,7-10\,21H2\,\(H\,24\,25\) xref: smiles:C1\(=CC=CC=C1C\(C4=C\(N\)N=C\(NC2=CN=C\(C=C2\)N3CCNCC3\)S4\)=O\)F is_a: CONSO:CONSO00278 ! diaminothiazole relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00253 name: Long-Term Depression namespace: pathology def: "A gradual weakening of neuronal synaptic connections lasting hours or longer following a long patterned stimulus. Along with LTP (long term potentiation) is one of the main mechanisms of memory formation, more specifically of spatial memory. The mechanism involves an interplay of NMDA and AMPA glutamate receptors, with minimal intracellular calcium levels triggering a cellular cascade leading to the removal of the latter and an overall decrease of the glutammate receptors in the postsynaptic neurons, thus weakening the synapse." [pubmed:22833681] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00254 name: Pathological Tau Spreading namespace: pathology def: "Pathological spreading pattern of tau into defined anatomycally interconnected brain regions during the progression of tauopathy." [pubmed:29540553] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00255 name: PrPSc namespace: isoform def: "PrPSc (scrapie isoform of the prion protein) prions are the infectious agent behind diseases such as Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy in cattle, chronic wasting disease in cervids (deer, elk, moose, and reindeer), as well as goat and sheep scrapie. PrPSc is an alternatively folded variant of the cellular prion protein, PrPC, which is a regular, GPI-anchored protein that is present on the cell surface of neurons and other cell types." [pubmed:22692785, pubmed:29414853] xref: uniprot:F7VJQ1 xref: uniprot.isoform:F7VJQ1-1 relationship: CONSO:has_reference_protein uniprot:P04156 relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00256 name: Tau Protein Secondary Structure, Turn def: "A turn-like structure formed in tau as a conseguence of the phosphorylation of only Ser202 and Thr205 residues, protects against aggregation." [pubmed:28784767] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00257 name: Tau antibody, RG7345 namespace: antibody def: "RG7345 is a humanized monoclonal antibody targeting the tau phosphoepitope pS422. Tau phosphorylated at this site is considered a pathological form that has been linked to the relocalization of tau away from microtubules and toward the somato-dendritic compartment of the neuron." [pubmed:26751493, pubmed:10967355] is_a: CONSO:CONSO00307 ! Tau antibody relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00258 name: RGFP966 namespace: chemical def: "Selective inhibitor of HDAC3" [pubmed:28771976] xref: chebi:131163 xref: inchi:InChI=1S/C21H19FN4O/c22-18-9-10-20\(19\(23\)13-18\)25-21\(27\)11-8-17-14-24-26\(15-17\)12-4-7-16-5-2-1-3-6-16/h1-11\,13-15H\,12\,23H2\,\(H\,25\,27\)/b7-4+\,11-8+ xref: pubchem.compound:56650312 xref: smiles:C1=CC=C\(C=C1\)C=CCN2C=C\(C=N2\)C=CC\(=O\)NC3=C\(C=C\(C=C3\)F\)N relationship: CONSO:author orcid:0000-0001-9661-5277 synonym: "(2E)-N-(2-amino-4-fluorophenyl)-3-{1-[(2E)-3-phenylprop-2-en-1-yl]-1H-pyrazol-4-yl}prop-2-enamide" EXACT [pubchem.compound:56650312] synonym: "(E)-N-(2-amino-4-fluorophenyl)-3-(1-cinnamyl-1H-pyrazol-4-yl)acrylamide" EXACT [pubchem.compound:56650312] synonym: "1357389-11-7" EXACT [pubchem.compound:56650312] synonym: "1396841-57-8" EXACT [pubchem.compound:56650312] synonym: "2-Propenamide, N-(2-amino-4-fluorophenyl)-3-[1-[(2E)-3-phenyl-2-propen-1-yl]-1H-pyrazol-4-yl]-, (2E)-" EXACT [pubchem.compound:56650312] synonym: "2686AH" EXACT [pubchem.compound:56650312] synonym: "A13218" EXACT [pubchem.compound:56650312] synonym: "AK676067" EXACT [pubchem.compound:56650312] synonym: "AKOS030526449" EXACT [pubchem.compound:56650312] synonym: "BC600495" EXACT [pubchem.compound:56650312] synonym: "BCP08102" EXACT [pubchem.compound:56650312] synonym: "BLVQHYHDYFTPDV-VCABWLAWSA-N" EXACT [pubchem.compound:56650312] synonym: "C21H19FN4O" EXACT [pubchem.compound:56650312] synonym: "CHEBI:131163" EXACT [pubchem.compound:56650312] synonym: "CHEMBL4078477" EXACT [pubchem.compound:56650312] synonym: "D00HXX" EXACT [pubchem.compound:56650312] synonym: "DA-45384" EXACT [pubchem.compound:56650312] synonym: "DA-45706" EXACT [pubchem.compound:56650312] synonym: "EX-A229" EXACT [pubchem.compound:56650312] synonym: "GTPL7500" EXACT [pubchem.compound:56650312] synonym: "J-007305" EXACT [pubchem.compound:56650312] synonym: "KB-148638" EXACT [pubchem.compound:56650312] synonym: "MFCD26960954" EXACT [pubchem.compound:56650312] synonym: "MolPort-035-395-807" EXACT [pubchem.compound:56650312] synonym: "QC-11774" EXACT [pubchem.compound:56650312] synonym: "RGFP 966" EXACT [pubchem.compound:56650312] synonym: "RGFP-966" EXACT [pubchem.compound:56650312] synonym: "RGFP966" EXACT [pubchem.compound:56650312] synonym: "RGFP966 Racemate" EXACT [pubchem.compound:56650312] synonym: "RGFP966, >=98% (HPLC)" EXACT [pubchem.compound:56650312] synonym: "SB19284" EXACT [pubchem.compound:56650312] synonym: "SCHEMBL12497867" EXACT [pubchem.compound:56650312] synonym: "SCHEMBL12497871" EXACT [pubchem.compound:56650312] synonym: "SW219401-1" EXACT [pubchem.compound:56650312] synonym: "ZINC95616594" EXACT [pubchem.compound:56650312] synonym: "s7229" EXACT [pubchem.compound:56650312] [Term] id: CONSO:CONSO00259 name: SL-327 namespace: chemical def: "Inhibitor of MAP2K1/2 kinases activity in murine neuroblastoma cell line N2A" [pubmed:24401760] xref: cas:305350-87-2 xref: chebi:92211 xref: inchi:InChI=1S/C16H12F3N3S/c17-16\(18\,19\)14-4-2-1-3-12\(14\)13\(9-20\)15\(22\)23-11-7-5-10\(21\)6-8-11/h1-8H\,21-22H2/b15-13+ xref: pubchem.compound:9549284 xref: smiles:C1=CC=C\(C\(=C1\)C\(=C\(N\)SC2=CC=C\(C=C2\)N\)C#N\)C\(F\)\(F\)F relationship: CONSO:author orcid:0000-0001-9661-5277 synonym: "(2Z)-3-amino-3-[(4-aminophenyl)sulfanyl]-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile" EXACT [pubchem.compound:9549284] synonym: "(Z)-3-amino-3-(4-aminophenylthio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile" EXACT [pubchem.compound:9549284] synonym: "3-amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile" EXACT [pubchem.compound:9549284] synonym: "3-amino-3-[(4-aminophenyl)sulfanyl]-2-[2-(trifluoromethyl)phenyl]acrylonitrile" EXACT [pubchem.compound:9549284] synonym: "3-amino-3-[(4-aminophenyl)thio]-2-[2-(trifluoromethyl)phenyl]-2-propenenitrile" EXACT [pubchem.compound:9549284] synonym: "305350-87-2" EXACT [pubchem.compound:9549284] synonym: "AKOS024456884" EXACT [pubchem.compound:9549284] synonym: "AOB5954" EXACT [pubchem.compound:9549284] synonym: "BC600460" EXACT [pubchem.compound:9549284] synonym: "BCP05310" EXACT [pubchem.compound:9549284] synonym: "BRD-K12244279-001-01-7" EXACT [pubchem.compound:9549284] synonym: "Benzeneacetonitrile, alpha-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)-" EXACT [pubchem.compound:9549284] synonym: "CCG-206867" EXACT [pubchem.compound:9549284] synonym: "CHEBI:92211" EXACT [pubchem.compound:9549284] synonym: "CS-0910" EXACT [pubchem.compound:9549284] synonym: "D04WPA" EXACT [pubchem.compound:9549284] synonym: "DTXSID90429549" EXACT [pubchem.compound:9549284] synonym: "E/Z-a-[amino[(4-aminophenyl)thio]methylen]-2-(trifluoromethyl)benzeneacetonitrile" EXACT [pubchem.compound:9549284] synonym: "EC-000.2354" EXACT [pubchem.compound:9549284] synonym: "EX-A1069" EXACT [pubchem.compound:9549284] synonym: "GTPL6008" EXACT [pubchem.compound:9549284] synonym: "HMS3229K18" EXACT [pubchem.compound:9549284] synonym: "HMS3678M21" EXACT [pubchem.compound:9549284] synonym: "HSCI1_000044" EXACT [pubchem.compound:9549284] synonym: "HY-15437" EXACT [pubchem.compound:9549284] synonym: "J-018001" EXACT [pubchem.compound:9549284] synonym: "JLOXTZFYJNCPIS-FYWRMAATSA-N" EXACT [pubchem.compound:9549284] synonym: "K00090" EXACT [pubchem.compound:9549284] synonym: "KB-80585" EXACT [pubchem.compound:9549284] synonym: "LS-193345" EXACT [pubchem.compound:9549284] synonym: "MEK1/2 Inhibitor" BROAD [orcid:0000-0001-9439-5346] synonym: "MFCD06411432" EXACT [pubchem.compound:9549284] synonym: "MolPort-006-069-021" EXACT [pubchem.compound:9549284] synonym: "NCGC00092290-01" EXACT [pubchem.compound:9549284] synonym: "NCGC00092290-02" EXACT [pubchem.compound:9549284] synonym: "SB19419" EXACT [pubchem.compound:9549284] synonym: "SCHEMBL570317" EXACT [pubchem.compound:9549284] synonym: "SCHEMBL570318" EXACT [pubchem.compound:9549284] synonym: "SL 327" EXACT [pubchem.compound:9549284] synonym: "SL-327" EXACT [pubchem.compound:9549284] synonym: "SL327" EXACT [pubchem.compound:9549284] synonym: "SL327, >=98% (HPLC), Mixture of E & Z isomers, solid" EXACT [pubchem.compound:9549284] synonym: "SW219839-1" EXACT [pubchem.compound:9549284] synonym: "W-5333" EXACT [pubchem.compound:9549284] synonym: "X3440" EXACT [pubchem.compound:9549284] synonym: "Z-& E-a-(Amino-((4-aminophenyl)thio)methylene)-2-(trifluoromethyl)benzeneacetonitrile" EXACT [pubchem.compound:9549284] synonym: "Z-& E-alpha-(Amino-((4-aminophenyl)thio)methylene)-2-(trifluoromethyl)benzeneacetonitrile" EXACT [pubchem.compound:9549284] synonym: "ZINC1910234" EXACT [pubchem.compound:9549284] synonym: "alpha-[Amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile" EXACT [pubchem.compound:9549284] synonym: "alpha-{amino[(4-aminophenyl)thio]methylene}-2-(trifluoromethyl)benzeneacetonitrile" EXACT [pubchem.compound:9549284] synonym: "s1066" EXACT [pubchem.compound:9549284] [Term] id: CONSO:CONSO00260 name: Spinocerebellar Ataxia 11 namespace: pathology def: "Spinocerebellar ataxia type 11 (SCA11) is characterized by progressive cerebellar ataxia and abnormal eye signs (jerky pursuit, horizontal and vertical nystagmus). Caused by mutations in the TTBK2 (Tau Tubulin Kinase 2) gene, is inherited in an autosomal dominant manner." [pubmed:21548880] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00261 name: ST7612AA1 namespace: chemical def: "A thiol derivative, pan-HDAC inhibitor" [pubmed:27917100] xref: chembl:CHEMBL3353926 xref: inchi:InChI=1S/C20H27N3O4S/c1-14\(24\)28-13-7-3-6-10-16\(19\(26\)21-15-8-4-2-5-9-15\)23-20\(27\)17-11-12-18\(25\)22-17/h2\,4-5\,8-9\,16-17H\,3\,6-7\,10-13H2\,1H3\,\(H\,21\,26\)\(H\,22\,25\)\(H\,23\,27\)/t16-\,17+/m0/s1 xref: pubchem.compound:71538210 xref: smiles:CC\(=O\)SCCCCC\[C@H\]\(NC\(=O\)\[C@H\]1CCC\(=O\)N1\)C\(=O\)Nc2ccccc2 relationship: CONSO:author orcid:0000-0001-9661-5277 synonym: "1428535-92-5" EXACT [pubchem.compound:71538210] synonym: "A14418" EXACT [pubchem.compound:71538210] synonym: "BDBM50027652" EXACT [pubchem.compound:71538210] synonym: "CHEMBL3353926" EXACT [pubchem.compound:71538210] synonym: "SB17083" EXACT [pubchem.compound:71538210] synonym: "SCHEMBL14812001" EXACT [pubchem.compound:71538210] synonym: "ST-7612AA1" EXACT [pubchem.compound:71538210] synonym: "Thioacetic acid S-[(S)-6-[[(R)-5-oxopyrrolidine-2-ylcarbonyl]amino]-6-(phenylcarbamoyl)hexyl] ester" EXACT [pubchem.compound:71538210] [Term] id: CONSO:CONSO00262 name: Tau antibody, AGG5759 namespace: antibody def: "Rabbit polyclonal antibody against tau pSer262, AstraZeneca" [pubmed:23666762] is_a: CONSO:CONSO00307 ! Tau antibody relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00263 name: Tau epitope, AD2 namespace: epitope def: "Tau epitope consisting of pThr396 and pSer404" [pubmed:11943212] is_a: CONSO:CONSO00307 ! Tau epitope relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00264 name: Tau epitope, AP422 namespace: epitope def: "Tau epitope consisting of pSer422" [pubmed:11943212] is_a: CONSO:CONSO00307 ! Tau epitope relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00265 name: Tau epitope, AT100 namespace: epitope def: "Tau epitope consisting of pSer214 and pThr212" [pubmed:22833681] is_a: CONSO:CONSO00307 ! Tau epitope relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00266 name: Tau epitope, AT270 namespace: epitope def: "Tau epitope consisting of pThr181" [pubmed:11943212] is_a: CONSO:CONSO00307 ! Tau epitope relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00267 name: Thiamet G namespace: chemical def: "Inhibitor of O-GlcNAcase (OGA)" [pubmed:22833681] xref: chembl:CHEMBL1213603 xref: inchi:InChI=1S/C9H16N2O4S/c1-2-10-9-11-5-7\(14\)6\(13\)4\(3-12\)15-8\(5\)16-9/h4-8\,12-14H\,2-3H2\,1H3\,\(H\,10\,11\)/t4-\,5-\,6-\,7-\,8-/m1/s1 xref: pubchem.compound:24808478 xref: smiles:CCNC1=NC2C\(C\(C\(OC2S1\)CO\)O\)O relationship: CONSO:author orcid:0000-0001-9661-5277 synonym: "(3aR)-2-(Ethylamino)-6beta,7alpha-dihydroxy-3aalpha,6,7,7aalpha-tetrahydro-5H-pyrano[3,2-d]thiazole-5alpha-methanol" EXACT [pubchem.compound:24808478] synonym: "(3aR,5R,6S,7R,7aR)-2-(Ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol" EXACT [pubchem.compound:24808478] synonym: "(3aR,5R,6S,7R,7aR)-2-(ethylamino)-5-(hydroxymethyl)-3a,6,7,7a-tetrahydro-5H-pyrano[3,2-d]thiazole-6,7-diol" EXACT [pubchem.compound:24808478] synonym: "(3aR,5R,6S,7R,7aR)-2-(ethylamino)-5-(hydroxymethyl)-3aH,5H,6H,7H,7aH-pyrano[3,2-d][1,3]thiazole-6,7-diol" EXACT [pubchem.compound:24808478] synonym: "1,2-Dideoxy-2'-ethylamino-a-D-glucopyranoso-[2,1-d]-2'-thiazoline" EXACT [pubchem.compound:24808478] synonym: "1009816-48-1" EXACT [pubchem.compound:24808478] synonym: "2070AH" EXACT [pubchem.compound:24808478] synonym: "2754AH" EXACT [pubchem.compound:24808478] synonym: "5H-Pyrano[3,2-d]thiazole-6,7-diol, 2-(ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-, (3aR,5R,6S,7R,7aR)-" EXACT [pubchem.compound:24808478] synonym: "ACN-038039" EXACT [pubchem.compound:24808478] synonym: "AKOS024458135" EXACT [pubchem.compound:24808478] synonym: "AOB5913" EXACT [pubchem.compound:24808478] synonym: "C9H16N2O4S" EXACT [pubchem.compound:24808478] synonym: "EX-A2240" EXACT [pubchem.compound:24808478] synonym: "HMS3648I18" EXACT [pubchem.compound:24808478] synonym: "HY-12588" EXACT [pubchem.compound:24808478] synonym: "J-000295" EXACT [pubchem.compound:24808478] synonym: "MFCD15144964" EXACT [pubchem.compound:24808478] synonym: "NCGC00344096-03" EXACT [pubchem.compound:24808478] synonym: "SR-01000946377" EXACT [pubchem.compound:24808478] synonym: "SR-01000946377-1" EXACT [pubchem.compound:24808478] synonym: "SW219118-1" EXACT [pubchem.compound:24808478] synonym: "Thiamet G" EXACT [pubchem.compound:24808478] synonym: "Thiamet G, >=98% (HPLC)" EXACT [pubchem.compound:24808478] synonym: "Thiamet G;\n2-(ethylamino)-3aR,6S,7R,7aR-tetrahydro-5R-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol" EXACT [pubchem.compound:24808478] synonym: "Thiamet-G" EXACT [pubchem.compound:24808478] synonym: "W-200641" EXACT [pubchem.compound:24808478] synonym: "ZINC16052637" EXACT [pubchem.compound:24808478] synonym: "s7213" EXACT [pubchem.compound:24808478] [Term] id: CONSO:CONSO00268 name: Thioflavin S namespace: chemical_mixture def: "Dye binding to PHF used in AD diagnostics" [pubmed:7667312] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00269 name: Trithiocarbonates namespace: chemical_class def: "Chemical compound group of susbtrate competitive selective HDAC6 inhibitors" [pubmed:18558669] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00270 name: Tubacin namespace: chemical def: "Inhibitor of HDAC6" [pubmed:23487739] xref: cas:537049-40-4 xref: chebi:94166 xref: inchi:InChI=1S/C41H43N3O7S/c45-26-28-17-19-29\(20-18-28\)35-25-34\(27-52-41-43-38\(30-11-5-3-6-12-30\)39\(51-41\)31-13-7-4-8-14-31\)49-40\(50-35\)32-21-23-33\(24-22-32\)42-36\(46\)15-9-1-2-10-16-37\(47\)44-48/h3-8\,11-14\,17-24\,34-35\,40\,45\,48H\,1-2\,9-10\,15-16\,25-27H2\,\(H\,42\,4 xref: iupac:N1-\[4-\[\(2R\,4R\,6S\)-4-\[\[\(4\,5-diphenyl-2-oxazolyl\)thio\]methyl\]-6-\[4-\(hydroxymethyl\)phenyl\]-1\,3-dioxan-2-yl\]phenyl\]-N8-hydroxy-octanediamide xref: smiles:O=C\(CCCCCCC\(NO\)=O\)NC\(C=C1\)=CC=C1\[C@@H\]2O\[C@H\]\(C3=CC=C\(CO\)C=C3\)C\[C@H\]\(CSC4=NC\(C5=CC=CC=C5\)=C\(C6=CC=CC=C6\)O4\)O2 relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00271 name: Tubastatin A namespace: chemical def: "Inhibitor of HDAC6 shown to also decrease tau hyperphosphorylation and Ab load" [pubmed:24844691] xref: cas:1252003-15-8 xref: chebi:94186 xref: inchi:InChI=1S/C20H21N3O2/c1-22-11-10-19-17\(13-22\)16-4-2-3-5-18\(16\)23\(19\)12-14-6-8-15\(9-7-14\)20\(24\)21-25/h2-9\,25H\,10-13H2\,1H3\,\(H\,21\,24\) xref: smiles:ONC\(C1=CC=C\(CN2C\(CCN\(C\)C3\)=C3C4=C2C=CC=C4\)C=C1\)=O relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00272 name: USP14 Aptamer namespace: aptamer def: "Inhibitory oligopeptide of the USP14, a deubiquitinating enzyme." [pubmed:26041011] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00273 name: cholinergic neuron namespace: anatomy def: "A neuron that uses acetylcholine as a vesicular neurotransmitter." [pubmed:29221819] xref: mesh:D059329 relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00274 name: cerebral cortex namespace: anatomy def: "The thin layer of gray matter on the surface of the cerebral hemisphere that develops from the telencephalon. It consists of the neocortex (6 layered cortex or isocortex), the hippocampal formation and the olfactory cortex." [pubmed:29221819] xref: mesh:D002540 relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00275 name: crebinostat namespace: chemical def: "Inhibitor of HDAC6" [pubmed:25546293] xref: cas:1092061-61-4 xref: inchi:InChI=1S/C20H23N3O3/c24-19\(9-5-2-6-10-20\(25\)23-26\)22-21-15-16-11-13-18\(14-12-16\)17-7-3-1-4-8-17/h1\,3-4\,7-8\,11-15\,26H\,2\,5-6\,9-10H2\,\(H\,22\,24\)\(H\,23\,25\)/b21-15+ xref: smiles:C1=CC=CC\(=C1\)C2=CC=C\(C=C2\)C=NNC\(CCCCCC\(=O\)NO\)=O relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00276 name: diaminothiazole namespace: chemical_class def: "Compound class with kinase inhibition properties, specifically for CDK5 and GSK3Beta" [pubmed:23737518] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00277 name: entorhinal cortex layer 2 namespace: anatomy def: "Layer of the entorhinal cortex lying superficial to layer 3 and deep to layer 1. It is characterized by medium-to large sized stellate cells that are grouped into prominent clusters, particularly in the rostral entorhinal cortex." [pubmed:27798139] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00278 name: granular layer of cerebellar cortex namespace: anatomy def: "The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [pubmed:29221819] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00279 name: indirubin namespace: chemical def: "A powerful inhibitor of GSK3B" [pubmed:11013232] xref: cas:479-41-4 xref: chemspider:4477010 xref: inchi:nChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12\(10\)17-14\(15\)13-9-5-1-3-7-11\(9\)18-16\(13\)20/h1-8\,17H\,\(H\,18\,20\)/b14-13- xref: smiles:c1ccc2c\(c1\)/C\(=C/3\\C\(=O\)c4ccccc4N3\)/C\(=O\)N2 relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00280 name: isocarboxazide namespace: chemical def: "Inhibitor of tau aggregation" [pubmed:26751493] xref: chebi:93635 xref: chembl:CHEMBL1201168 xref: drugbank:DB01247 xref: inchi:InChI=1S/C12H13N3O2/c1-9-7-11\(15-17-9\)12\(16\)14-13-8-10-5-3-2-4-6-10/h2-7\,13H\,8H2\,1H3\,\(H\,14\,16\) xref: pubchem.compound:3759 xref: smiles:CC1=CC\(=NO1\)C\(=O\)NNCC1=CC=CC=C1 relationship: ro:0000087 CONSO:CONSO00321 relationship: CONSO:author orcid:0000-0001-9661-5277 synonym: "1-Benzyl-2-(5-methyl-3-isoxazolyl-carbonyl)hydrazine" EXACT [pubchem.compound:3759] synonym: "1-Benzyl-2-(5-methyl-3-isoxazolylcarbonyl)hydrazine" EXACT [pubchem.compound:3759] synonym: "3-(2-BENZYLHYDRAZOCARBOXY)-5-METHYL-ISOXAZOLE" EXACT [pubchem.compound:3759] synonym: "3-Isoxazolecarboxylic acid, 2-(phenylmethyl)hydrazide" EXACT [pubchem.compound:3759] synonym: "3-Isoxazolecarboxylic acid, 2-benzylhydrazide" EXACT [pubchem.compound:3759] synonym: "3-Isoxazolecarboxylic acid, 5-methyl-, 2-(phenylmethyl)hydrazide" EXACT [pubchem.compound:3759] synonym: "3-Isoxazolecarboxylic acid, 5-methyl-, 2-benzylhydrazide" EXACT [pubchem.compound:3759] synonym: "34237V843T" EXACT [pubchem.compound:3759] synonym: "4-27-00-03999 (Beilstein Handbook Reference)" EXACT [pubchem.compound:3759] synonym: "5-Methyl-3-isoxazolecarboxylic acid 2-benzylhydrazide" EXACT [pubchem.compound:3759] synonym: "5-methyl-N'-(phenylmethyl)-3-isoxazolecarbohydrazide" EXACT [pubchem.compound:3759] synonym: "5-methyl-N'-(phenylmethyl)isoxazole-3-carbohydrazide" EXACT [pubchem.compound:3759] synonym: "59-63-2" EXACT [pubchem.compound:3759] synonym: "AB00513923" EXACT [pubchem.compound:3759] synonym: "AC-24841" EXACT [pubchem.compound:3759] synonym: "AC1L1GNE" EXACT [pubchem.compound:3759] synonym: "AJ-08053" EXACT [pubchem.compound:3759] synonym: "AKOS016003091" EXACT [pubchem.compound:3759] synonym: "ANW-58213" EXACT [pubchem.compound:3759] synonym: "API0000611" EXACT [pubchem.compound:3759] synonym: "AX8135097" EXACT [pubchem.compound:3759] synonym: "BC645218" EXACT [pubchem.compound:3759] synonym: "BDBM163692" EXACT [pubchem.compound:3759] synonym: "BMIH" EXACT [pubchem.compound:3759] synonym: "BPBio1_001024" EXACT [pubchem.compound:3759] synonym: "BRD-K93332168-001-03-2" EXACT [pubchem.compound:3759] synonym: "BRN 0201295" EXACT [pubchem.compound:3759] synonym: "BSPBio_000930" EXACT [pubchem.compound:3759] synonym: "Benazide" EXACT [pubchem.compound:3759] synonym: "CAS-59-63-2" EXACT [pubchem.compound:3759] synonym: "CCG-220795" EXACT [pubchem.compound:3759] synonym: "CCRIS 9178" EXACT [pubchem.compound:3759] synonym: "CHEBI:93635" EXACT [pubchem.compound:3759] synonym: "CHEMBL1201168" EXACT [pubchem.compound:3759] synonym: "CS-0008613" EXACT [pubchem.compound:3759] synonym: "CTK8B7692" EXACT [pubchem.compound:3759] synonym: "D02580" EXACT [pubchem.compound:3759] synonym: "D0I2VK" EXACT [pubchem.compound:3759] synonym: "DB01247" EXACT [pubchem.compound:3759] synonym: "DSSTox_CID_3171" EXACT [pubchem.compound:3759] synonym: "DSSTox_GSID_23171" EXACT [pubchem.compound:3759] synonym: "DSSTox_RID_76902" EXACT [pubchem.compound:3759] synonym: "DTXSID4023171" EXACT [pubchem.compound:3759] synonym: "EINECS 200-438-4" EXACT [pubchem.compound:3759] synonym: "Enerzer" EXACT [pubchem.compound:3759] synonym: "FCH2716017" EXACT [pubchem.compound:3759] synonym: "FT-0670438" EXACT [pubchem.compound:3759] synonym: "GTPL7204" EXACT [pubchem.compound:3759] synonym: "HMS1570O12" EXACT [pubchem.compound:3759] synonym: "HMS2097O12" EXACT [pubchem.compound:3759] synonym: "HMS2230E11" EXACT [pubchem.compound:3759] synonym: "HMS3369G18" EXACT [pubchem.compound:3759] synonym: "HMS3714O12" EXACT [pubchem.compound:3759] synonym: "HY-13929" EXACT [pubchem.compound:3759] synonym: "ISOCARBOXAZID (200 MG)" EXACT [pubchem.compound:3759] synonym: "Isocarbonazid" EXACT [pubchem.compound:3759] synonym: "Isocarbossazide" EXACT [pubchem.compound:3759] synonym: "Isocarbossazide [DCIT]" EXACT [pubchem.compound:3759] synonym: "Isocarboxazid (ICD)" EXACT [pubchem.compound:3759] synonym: "Isocarboxazid (INN)" EXACT [pubchem.compound:3759] synonym: "Isocarboxazid 5-methyl-3-isoxazole-carboxylic acid 2-benzylhydrazide, AldrichCPR" EXACT [pubchem.compound:3759] synonym: "Isocarboxazid [INN:BAN]" EXACT [pubchem.compound:3759] synonym: "Isocarboxazid [USP:INN:BAN]" EXACT [pubchem.compound:3759] synonym: "Isocarboxazida" EXACT [pubchem.compound:3759] synonym: "Isocarboxazida [INN-Spanish]" EXACT [pubchem.compound:3759] synonym: "Isocarboxazide" EXACT [pubchem.compound:3759] synonym: "Isocarboxazide [INN-French]" EXACT [pubchem.compound:3759] synonym: "Isocarboxazidum" EXACT [pubchem.compound:3759] synonym: "Isocarboxazidum [INN-Latin]" EXACT [pubchem.compound:3759] synonym: "Isocarboxizid" EXACT [pubchem.compound:3759] synonym: "Isocarboxyzid" EXACT [pubchem.compound:3759] synonym: "KB-258619" EXACT [pubchem.compound:3759] synonym: "LS-86607" EXACT [pubchem.compound:3759] synonym: "MLS002154005" EXACT [pubchem.compound:3759] synonym: "MLS003106729" EXACT [pubchem.compound:3759] synonym: "Maraplan" EXACT [pubchem.compound:3759] synonym: "Marplan" EXACT [pubchem.compound:3759] synonym: "Marplan (TN)" EXACT [pubchem.compound:3759] synonym: "Marplon" EXACT [pubchem.compound:3759] synonym: "N'-Benzyl N-methyl-5-isoxazolecarboxylhydrazide-3" EXACT [pubchem.compound:3759] synonym: "N'-Benzyl-5-methyl-3-isoxazolecarbohydrazide #" EXACT [pubchem.compound:3759] synonym: "N'-Benzyl-5-methylisoxazole-3-carbohydrazide" EXACT [pubchem.compound:3759] synonym: "N'-benzyl-5-methyl-1,2-oxazole-3-carbohydrazide" EXACT [pubchem.compound:3759] synonym: "NCGC00016267-01" EXACT [pubchem.compound:3759] synonym: "NCGC00016267-02" EXACT [pubchem.compound:3759] synonym: "NCGC00016267-03" EXACT [pubchem.compound:3759] synonym: "NSC 169893" EXACT [pubchem.compound:3759] synonym: "NSC-169893" EXACT [pubchem.compound:3759] synonym: "NSC169893" EXACT [pubchem.compound:3759] synonym: "Prestwick0_000795" EXACT [pubchem.compound:3759] synonym: "Prestwick1_000795" EXACT [pubchem.compound:3759] synonym: "Prestwick2_000795" EXACT [pubchem.compound:3759] synonym: "Prestwick3_000795" EXACT [pubchem.compound:3759] synonym: "Ro 5-0831" EXACT [pubchem.compound:3759] synonym: "Ro 5-0831/1" EXACT [pubchem.compound:3759] synonym: "Ro5-0831" EXACT [pubchem.compound:3759] synonym: "SCHEMBL49562" EXACT [pubchem.compound:3759] synonym: "SMR001233334" EXACT [pubchem.compound:3759] synonym: "SPBio_002869" EXACT [pubchem.compound:3759] synonym: "SR-01000841192" EXACT [pubchem.compound:3759] synonym: "SR-01000841192-2" EXACT [pubchem.compound:3759] synonym: "SR-01000841192-3" EXACT [pubchem.compound:3759] synonym: "TC-146958" EXACT [pubchem.compound:3759] synonym: "Tox21_110336" EXACT [pubchem.compound:3759] synonym: "UNII-34237V843T" EXACT [pubchem.compound:3759] synonym: "WLN: T5NOJ C1 EVMM1R" EXACT [pubchem.compound:3759] synonym: "XKFPYPQQHFEXRZ-UHFFFAOYSA-N" EXACT [pubchem.compound:3759] synonym: "Y0484" EXACT [pubchem.compound:3759] synonym: "ZINC1587" EXACT [pubchem.compound:3759] synonym: "isocarboxazid" EXACT [pubchem.compound:3759] [Term] id: CONSO:CONSO00281 name: isopentanyladenine namespace: chemical def: "Inhibitor of CKD5 activity" [pubmed:8726973] xref: chebi:17660 xref: drugbank:DB08768 xref: inchi:InChI=1S/C10H13N5/c1-7\(2\)3-4-11-9-8-10\(13-5-12-8\)15-6-14-9/h3\,5-6H\,4H2\,1-2H3\,\(H2\,11\,12\,13\,14\,15\) xref: pubchem.compound:92180 xref: smiles:CC\(=CCNC1=NC=NC2=C1NC=N2\)C relationship: CONSO:author orcid:0000-0001-9661-5277 synonym: "(3-methyl-but-2-enyl)-(7(9)H-purin-6-yl)-amine" EXACT [pubchem.compound:92180] synonym: "(3-methylbut-2-enyl)purin-6-ylamine" EXACT [pubchem.compound:92180] synonym: "13255-47-5" EXACT [pubchem.compound:92180] synonym: "1H-Purin-6-amine, N-(3-methyl-2-butenyl)-" EXACT [pubchem.compound:92180] synonym: "1H-Purin-6-amine, N-(3-methyl-2-butenyl)- (9CI)" EXACT [pubchem.compound:92180] synonym: "2365-40-4" EXACT [pubchem.compound:92180] synonym: "2exm" EXACT [pubchem.compound:92180] synonym: "3-methylbut-2-enyl(7H-purin-6-yl)amine" EXACT [pubchem.compound:92180] synonym: "365I404" EXACT [pubchem.compound:92180] synonym: "5122-37-2" EXACT [pubchem.compound:92180] synonym: "6-((3-Methyl-2-butenyl)amino)purine" EXACT [pubchem.compound:92180] synonym: "6-(.gamma.,.gamma.-Dimethylallylamino)purine" EXACT [pubchem.compound:92180] synonym: "6-(3,3-DIMETHYLALLYLAMINO)PURINE" EXACT [pubchem.compound:92180] synonym: "6-(3-methyl-2-buten-1-ylamino)purine" EXACT [pubchem.compound:92180] synonym: "6-(gamma,gamma-DIMETHYLALLYLAMINO) PURINE" EXACT [pubchem.compound:92180] synonym: "6-(gamma,gamma-Dimethylallylamino)purine" EXACT [pubchem.compound:92180] synonym: "6-(gamma,gamma-Dimethylallylamino)purine, BioReagent, plant cell culture tested, 1 mg/mL" EXACT [pubchem.compound:92180] synonym: "6-(gamma,gamma-Dimethylallylamino)purine, BioReagent, plant cell culture tested, >=90%" EXACT [pubchem.compound:92180] synonym: "6-(gamma,gamma-Dimethylallylamino)purine, BioReagent, plant cell culture tested, >=98.5%" EXACT [pubchem.compound:92180] synonym: "6-(gamma,gamma-Dimethylallylamino)purine, Vetec(TM) reagent grade, >=98.5%" EXACT [pubchem.compound:92180] synonym: "6-(|A,|A-Dimethylallylamino)purine" EXACT [pubchem.compound:92180] synonym: "6-[(3-Methyl-2-butenyl)amino]purine" EXACT [pubchem.compound:92180] synonym: "6-[(3-methylbut-2-en-1-yl)amino]purine" EXACT [pubchem.compound:92180] synonym: "A816825" EXACT [pubchem.compound:92180] synonym: "AC-15608" EXACT [pubchem.compound:92180] synonym: "AC1L3NL1" EXACT [pubchem.compound:92180] synonym: "ACM2365404" EXACT [pubchem.compound:92180] synonym: "AK163607" EXACT [pubchem.compound:92180] synonym: "AKOS005257639" EXACT [pubchem.compound:92180] synonym: "AKOS015914857" EXACT [pubchem.compound:92180] synonym: "AKOS028109417" EXACT [pubchem.compound:92180] synonym: "AN-50750" EXACT [pubchem.compound:92180] synonym: "AS-17517" EXACT [pubchem.compound:92180] synonym: "AX8017021" EXACT [pubchem.compound:92180] synonym: "Adenine, N-(3-methyl-2-butenyl)-" EXACT [pubchem.compound:92180] synonym: "Adenine, N-(3-methyl-2-butenyl)- (8CI)" EXACT [pubchem.compound:92180] synonym: "BC209320" EXACT [pubchem.compound:92180] synonym: "BID525" EXACT [pubchem.compound:92180] synonym: "BRD-K62158429-001-01-7" EXACT [pubchem.compound:92180] synonym: "C04083" EXACT [pubchem.compound:92180] synonym: "CCG-38046" EXACT [pubchem.compound:92180] synonym: "CHEBI:17660" EXACT [pubchem.compound:92180] synonym: "CHEMBL476189" EXACT [pubchem.compound:92180] synonym: "CI-027" EXACT [pubchem.compound:92180] synonym: "CS-0043352" EXACT [pubchem.compound:92180] synonym: "CTK8G1492" EXACT [pubchem.compound:92180] synonym: "D-4760" EXACT [pubchem.compound:92180] synonym: "D0I1SZ" EXACT [pubchem.compound:92180] synonym: "DB08768" EXACT [pubchem.compound:92180] synonym: "DTXSID10178325" EXACT [pubchem.compound:92180] synonym: "Dimethylallyladenine" EXACT [pubchem.compound:92180] synonym: "EBD28940" EXACT [pubchem.compound:92180] synonym: "Enadenine" EXACT [pubchem.compound:92180] synonym: "FT-0629731" EXACT [pubchem.compound:92180] synonym: "HMS1543F03" EXACT [pubchem.compound:92180] synonym: "HY-112103" EXACT [pubchem.compound:92180] synonym: "HYVABZIGRDEKCD-UHFFFAOYSA-N" EXACT [pubchem.compound:92180] synonym: "I14-7114" EXACT [pubchem.compound:92180] synonym: "IPADE" EXACT [pubchem.compound:92180] synonym: "Isopentenyl adenine" EXACT [pubchem.compound:92180] synonym: "Isopentenyladenine" EXACT [pubchem.compound:92180] synonym: "KB-57456" EXACT [pubchem.compound:92180] synonym: "LS-184209" EXACT [pubchem.compound:92180] synonym: "MCULE-6781114249" EXACT [pubchem.compound:92180] synonym: "MFCD00132998" EXACT [pubchem.compound:92180] synonym: "MolPort-002-511-573" EXACT [pubchem.compound:92180] synonym: "N(6)-(.DELTA.2-Isopentenyl)aminopurine" EXACT [pubchem.compound:92180] synonym: "N(6)-(Delta2-isopentenyl)adenine" EXACT [pubchem.compound:92180] synonym: "N(6)-(delta(2)-Isopentenyl)adenine" EXACT [pubchem.compound:92180] synonym: "N(6)-dimethylallyladenine" EXACT [pubchem.compound:92180] synonym: "N-(.DELTA.2-Isopentenyl)adenine" EXACT [pubchem.compound:92180] synonym: "N-(.gamma.,.gamma.-Dimethylallyl)adenine" EXACT [pubchem.compound:92180] synonym: "N-(3-METHYLBUT-2-EN-1-YL)-9H-PURIN-6-AMINE" EXACT [pubchem.compound:92180] synonym: "N-(3-Methyl-2-butenyl)-1H-purin-6-amine" EXACT [pubchem.compound:92180] synonym: "N-(3-Methyl-2-butenyl)-1H-purin-6-amine #" EXACT [pubchem.compound:92180] synonym: "N-(3-Methyl-2-butenyl)adenine" EXACT [pubchem.compound:92180] synonym: "N-(3-methyl-2-butenyl)-9H-purin-6-amine" EXACT [pubchem.compound:92180] synonym: "N-(3-methylbut-2-en-1-yl)-7H-purin-6-amine" EXACT [pubchem.compound:92180] synonym: "N-(3-methylbut-2-enyl)-7H-purin-6-amine" EXACT [pubchem.compound:92180] synonym: "N-(3-methylbut-2-enyl)-9H-purin-6-amine" EXACT [pubchem.compound:92180] synonym: "N-(delta2-Isopentenyl)adenine" EXACT [pubchem.compound:92180] synonym: "N-(gamma,gamma-Dimethylallyl)adenine" EXACT [pubchem.compound:92180] synonym: "N-6-(3,3-Dimethylallyl)adenine" EXACT [pubchem.compound:92180] synonym: "N-6-(delta2-Isopentenyl)-adenine" EXACT [pubchem.compound:92180] synonym: "N6 -(Delta2 -Isopentenyl)adenine" EXACT [pubchem.compound:92180] synonym: "N6-(.DELTA.2-Isopentenyl)adenine" EXACT [pubchem.compound:92180] synonym: "N6-(.DELTA.2-Isopentenyl)aminopurine" EXACT [pubchem.compound:92180] synonym: "N6-(2-Isopentenyl)-adenine" EXACT [pubchem.compound:92180] synonym: "N6-(2-Isopentenyl)adenine" EXACT [pubchem.compound:92180] synonym: "N6-(3-Methyl-2-butenyl)adenine" EXACT [pubchem.compound:92180] synonym: "N6-(3-Methylbut-2-enyl)adenine" EXACT [pubchem.compound:92180] synonym: "N6-(delta 2-Isopentenyl)-adenine" EXACT [pubchem.compound:92180] synonym: "N6-(delta2-Isopentenyl)-adenine" EXACT [pubchem.compound:92180] synonym: "N6-(delta2-Isopentenyl)adenine" EXACT [pubchem.compound:92180] synonym: "N6-(delta2-Isopentenyl)aminopurine" EXACT [pubchem.compound:92180] synonym: "N6-.DELTA.2-Isopentenyl)adenine" EXACT [pubchem.compound:92180] synonym: "N6-Delta2-isopentenyladenine" EXACT [pubchem.compound:92180] synonym: "N6-Dimethylallyladenine" EXACT [pubchem.compound:92180] synonym: "N6-Isopentenyladenine" EXACT [pubchem.compound:92180] synonym: "NCGC00014084" EXACT [pubchem.compound:92180] synonym: "NCGC00014084-02" EXACT [pubchem.compound:92180] synonym: "NCGC00097193-01" EXACT [pubchem.compound:92180] synonym: "NCI106958" EXACT [pubchem.compound:92180] synonym: "NCI60_000165" EXACT [pubchem.compound:92180] synonym: "NCIStruc1_000935" EXACT [pubchem.compound:92180] synonym: "NCIStruc2_000921" EXACT [pubchem.compound:92180] synonym: "NSC 106958" EXACT [pubchem.compound:92180] synonym: "NSC-106958" EXACT [pubchem.compound:92180] synonym: "NSC106958" EXACT [pubchem.compound:92180] synonym: "Oprea1_344117" EXACT [pubchem.compound:92180] synonym: "SC-18768" EXACT [pubchem.compound:92180] synonym: "SCHEMBL459276" EXACT [pubchem.compound:92180] synonym: "ST044513" EXACT [pubchem.compound:92180] synonym: "ST24048354" EXACT [pubchem.compound:92180] synonym: "TimTec1_003281" EXACT [pubchem.compound:92180] synonym: "UNII-V500BB256Z" EXACT [pubchem.compound:92180] synonym: "V0538" EXACT [pubchem.compound:92180] synonym: "V500BB256Z" EXACT [pubchem.compound:92180] synonym: "ZB000921" EXACT [pubchem.compound:92180] synonym: "ZINC32351" EXACT [pubchem.compound:92180] synonym: "ZX-AFC000343" EXACT [pubchem.compound:92180] synonym: "isopentenyl-adenine" EXACT [pubchem.compound:92180] synonym: "n-isopentenyladenine" EXACT [pubchem.compound:92180] [Term] id: CONSO:CONSO00282 name: maitotoxin namespace: chemical def: "Increases intracellular calcium levels, and induces the association of TGM2 with tau, positively affecting the activity of the former" [pubmed:10537045] xref: cas:59392-53-9 xref: chembl:ChEMBL2152261 xref: chemspider:25991548 xref: inchi:InChI=1S/C164H258O68S2.2Na/c1-24-26-65\(2\)68\(5\)41-74\(168\)117\(179\)85-33-36-152\(11\)106\(203-85\)55-109-162\(21\,231-152\)64-161\(20\)105\(210-109\)51-89-83\(220-161\)28-25-27-82-99\(199-89\)59-157\(16\)108\(202-82\)56-107-153\(12\,230-157\)39-38-151\(10\)112\(211-107\)61-158\(17\)111\(224-151\)54-101\(176\)163\(22\,232-158\)103-32-31-84-90\(204-103\)53-110-156\(15\,219-84\)62-113-150\(9\,223-110\)37-34-102-155\(14\,225-113\)63-114-164\(23\,227-102\)147\(192\)149-159\(18\,226-114\)58-81\(175\)134\(218-149\)133-79\(173\)47-93-136\(216-133\)120\(182\)119\(181\)92\(200-93\)44-72\(166\)43-76\(170\)131-77\(171\)46-94-137\(214-131\)122\(184\)124\(186\)143\(207-94\)145-126\(188\)125\(187\)144-146\(217-145\)128\(190\)139-97\(208-144\)50-88-87\(206-139\)49-96-138\(205-88\)127\(189\)141\(229-234\(196\,197\)198\)95\(201-96\)45-75\(169\)118\(180\)132-78\(172\)48-98-140\(215-132\)129\(191\)148-160\(19\,221-98\)60-100-91\(209-148\)52-104-154\(13\,222-100\)57-80\(174\)135-142\(212-104\)123\(185\)121\(183\)130\(213-135\)71\(8\)115\(177\)67\(4\)29-30-86\(228-233\(193\,194\)195\)116\(178\)69\(6\)42-73\(167\)70\(7\)66\(3\)35-40-165;;/h24-25\,28\,35\,65\,67-69\,71-149\,165-192H\,1\,7\,26-27\,29-34\,36-64H2\,2-6\,8-23H3\,\(H\,193\,194\,195\)\(H\,196\,197\,198\);;/q;2*+1/p-2/b28-25-\,66-35+;;/t65-\,67+\,68+\,69+\,71+\,72+\,73+\,74+\,75-\,76+\,77+\,78+\,79+\,80+\,81+\,82+\,83-\,84+\,85-\,86-\,87-\,88+\,89+\,90-\,91-\,92-\,93-\,94-\,95-\,96+\,97-\,98+\,99-\,100+\,101+\,102+\,103-\,104+\,105-\,106-\,107+\,108-\,109+\,110+\,111-\,112-\,113+\,114+\,115+\,116+\,117-\,118+\,119-\,120+\,121+\,122+\,123-\,124+\,125+\,126+\,127+\,128+\,129-\,130-\,131-\,132-\,133+\,134+\,135+\,136+\,137+\,138+\,139-\,140+\,141-\,142-\,143+\,144-\,145+\,146+\,147-\,148+\,149+\,150-\,151+\,152+\,153-\,154-\,155-\,156-\,157+\,158+\,159-\,160-\,161+\,162-\,163+\,164+;;/m0../s1 xref: pubchem.compound:71460273 xref: smiles:C\[C@H\]\(CC\[C@@H\]\(\[C@@H\]\(\[C@H\]\(C\)C\[C@H\]\(C\(=C\)/C\(=C/CO\)/C\)O\)O\)OS\(=O\)\(=O\)\[O-\]\)\[C@H\]\(\[C@@H\]\(C\)\[C@H\]1\[C@@H\]\(\[C@@H\]\(\[C@H\]2\[C@H\]\(O1\)\[C@@H\]\(C\[C@\]3\(\[C@H\]\(O2\)C\[C@H\]4\[C@H\]\(O3\)C\[C@\]5\(\[C@H\]\(O4\)\[C@H\]\(\[C@H\]6\[C@H\]\(O5\)C\[C@H\]\(\[C@H\]\(O6\)\[C@@H\]\(\[C@H\]\(C\[C@H\]7\[C@@H\]\(\[C@@H\]\(\[C@H\]8\[C@H\]\(O7\)C\[C@H\]9\[C@H\]\(O8\)C\[C@H\]1\[C@H\]\(O9\)\[C@H\]\(\[C@@H\]2\[C@@H\]\(O1\)\[C@@H\]\(\[C@H\]\(\[C@@H\]\(O2\)\[C@H\]1\[C@@H\]\(\[C@H\]\(\[C@H\]2\[C@@H\]\(O1\)C\[C@H\]\(\[C@@H\]\(O2\)\[C@@H\]\(C\[C@H\]\(C\[C@H\]1\[C@@H\]\(\[C@H\]\(\[C@H\]2\[C@@H\]\(O1\)C\[C@H\]\(\[C@@H\]\(O2\)\[C@H\]1\[C@@H\]\(C\[C@\]2\(\[C@H\]\(O1\)\[C@@H\]\(\[C@\]1\(\[C@H\]\(O2\)C\[C@\]2\(\[C@H\]\(O1\)CC\[C@\]1\(\[C@H\]\(O2\)C\[C@\]2\(\[C@H\]\(O1\)C\[C@H\]1\[C@H\]\(O2\)CC\[C@H\]\(O1\)\[C@\]1\(\[C@@H\]\(C\[C@H\]2\[C@\]\(O1\)\(C\[C@H\]1\[C@\]\(O2\)\(CC\[C@\]2\(\[C@H\]\(O1\)C\[C@H\]1\[C@\]\(O2\)\(C\[C@H\]2\[C@H\]\(O1\)C/C=C\\\[C@H\]1\[C@H\]\(O2\)C\[C@H\]2\[C@\]\(O1\)\(C\[C@\]1\(\[C@H\]\(O2\)C\[C@H\]2\[C@\]\(O1\)\(CC\[C@H\]\(O2\)\[C@H\]\(\[C@@H\]\(C\[C@@H\]\(C\)\[C@@H\]\(C\)CC=C\)O\)O\)C\)C\)C\)C\)C\)C\)C\)O\)C\)C\)C\)C\)C\)O\)C\)O\)O\)O\)O\)O\)O\)O\)O\)O\)O\)O\)O\)O\)OS\(=O\)\(=O\)\[O-\]\)O\)O\)O\)O\)C\)C\)O\)O\)O\)O.\[Na+\].\[Na+\] relationship: CONSO:author orcid:0000-0001-9661-5277 synonym: "9P59GES78D" EXACT [pubchem.compound:71460273] synonym: "CHEMBL2152261" EXACT [pubchem.compound:71460273] synonym: "HSDB 7753" EXACT [pubchem.compound:71460273] synonym: "Maitotoxin" EXACT [pubchem.compound:71460273] synonym: "Maitotoxin 1" EXACT [pubchem.compound:71460273] synonym: "UNII-9P59GES78D" EXACT [pubchem.compound:71460273] [Term] id: CONSO:CONSO00283 name: olomoucine namespace: chemical def: "Inhibitor of CKD5 activity" [pubmed:8726973] xref: chebi:44661 xref: drugbank:DB02116 xref: inchi:InChI=1S/C15H18N6O/c1-21-10-18-12-13\(17-9-11-5-3-2-4-6-11\)19-15\(16-7-8-22\)20-14\(12\)21/h2-6\,10\,22H\,7-9H2\,1H3\,\(H2\,16\,17\,19\,20\) xref: pubchem.compound:4592 xref: smiles:CN1C=NC2=C1N=C\(NCCO\)N=C2NCC1=CC=CC=C1 relationship: CONSO:author orcid:0000-0001-9661-5277 synonym: "101622-51-9" EXACT [pubchem.compound:4592] synonym: "1966AH" EXACT [pubchem.compound:4592] synonym: "1w0x" EXACT [pubchem.compound:4592] synonym: "2,6,9-Trisubstituted purine deriv. 26" EXACT [pubchem.compound:4592] synonym: "2-(2-Hydroxyethylamino)-6-(benzylamino)-9-methylpurine" EXACT [pubchem.compound:4592] synonym: "2-(2-Hydroxyethylamino)-6-benzylamino-9-isopropylpurine" EXACT [pubchem.compound:4592] synonym: "2-(2-Hydroxyethylamino)-6-benzylamino-9-methylpurine" EXACT [pubchem.compound:4592] synonym: "2-(6-(benzylamino)-9-methyl-9H-purin-2-ylamino)ethanol" EXACT [pubchem.compound:4592] synonym: "2-(Hydroxyethylamino)-6-benzylamino-9-methylpurine" EXACT [pubchem.compound:4592] synonym: "2-({9-methyl-6-[benzylamino]purin-2-yl}amino)ethan-1-ol" EXACT [pubchem.compound:4592] synonym: "2-[[6-(benzylamino)-9-methyl-purin-2-yl]amino]ethanol" EXACT [pubchem.compound:4592] synonym: "2-[[6-(benzylamino)-9-methylpurin-2-yl]amino]ethanol" EXACT [pubchem.compound:4592] synonym: "2-[[9-Methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-ethanol" EXACT [pubchem.compound:4592] synonym: "2-[[9-Methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]ethanol" EXACT [pubchem.compound:4592] synonym: "2-[[9-Methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]ethanol, 9CI" EXACT [pubchem.compound:4592] synonym: "2-[[9-methyl-6-(phenylmethylamino)purin-2-yl]amino]ethanol" EXACT [pubchem.compound:4592] synonym: "2-{[6-(benzylamino)-9-methyl-9H-purin-2-yl]amino}ethan-1-ol" EXACT [pubchem.compound:4592] synonym: "2-{[6-(benzylamino)-9-methyl-9h-purin-2-yl]amino}ethanol" EXACT [pubchem.compound:4592] synonym: "4erk" EXACT [pubchem.compound:4592] synonym: "6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine" EXACT [pubchem.compound:4592] synonym: "6-(benzylamino)-2-[(2-hydroxyethyl)amino]-9-methylpurine" EXACT [pubchem.compound:4592] synonym: "6-Benylamino-2-(2-hydroxyethylamino)-9-methylpurine" EXACT [pubchem.compound:4592] synonym: "6-Benzylamino-2-(2-hydroxyethylamino)-9-methylpurine" EXACT [pubchem.compound:4592] synonym: "6-benzylamino-2-[2-hydroxyethylamino]-9-methylpurine" EXACT [pubchem.compound:4592] synonym: "6A839B2HYS" EXACT [pubchem.compound:4592] synonym: "AC1L1IID" EXACT [pubchem.compound:4592] synonym: "AC1Q4XZU" EXACT [pubchem.compound:4592] synonym: "ACMC-20cp0o" EXACT [pubchem.compound:4592] synonym: "AKOS005145988" EXACT [pubchem.compound:4592] synonym: "BCBcMAP01_000205" EXACT [pubchem.compound:4592] synonym: "BDBM5718" EXACT [pubchem.compound:4592] synonym: "BIO3107" EXACT [pubchem.compound:4592] synonym: "BMK1-E10" EXACT [pubchem.compound:4592] synonym: "BRD-K82731415-001-03-9" EXACT [pubchem.compound:4592] synonym: "BRD-K82731415-001-04-7" EXACT [pubchem.compound:4592] synonym: "BSPBio_000990" EXACT [pubchem.compound:4592] synonym: "Bio1_000336" EXACT [pubchem.compound:4592] synonym: "Bio1_000825" EXACT [pubchem.compound:4592] synonym: "Bio1_001314" EXACT [pubchem.compound:4592] synonym: "Bio2_000335" EXACT [pubchem.compound:4592] synonym: "Bio2_000815" EXACT [pubchem.compound:4592] synonym: "BiomolKI2_000052" EXACT [pubchem.compound:4592] synonym: "BiomolKI_000046" EXACT [pubchem.compound:4592] synonym: "C-28477" EXACT [pubchem.compound:4592] synonym: "C15H18N6O" EXACT [pubchem.compound:4592] synonym: "CBiol_002050" EXACT [pubchem.compound:4592] synonym: "CCG-100650" EXACT [pubchem.compound:4592] synonym: "CHEMBL280074" EXACT [pubchem.compound:4592] synonym: "CJ-26517" EXACT [pubchem.compound:4592] synonym: "CTK4A0020" EXACT [pubchem.compound:4592] synonym: "D00BPA" EXACT [pubchem.compound:4592] synonym: "DB02116" EXACT [pubchem.compound:4592] synonym: "DTXSID90144068" EXACT [pubchem.compound:4592] synonym: "EU-0100883" EXACT [pubchem.compound:4592] synonym: "Ethanol, 2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-" EXACT [pubchem.compound:4592] synonym: "Ethanol,2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-" EXACT [pubchem.compound:4592] synonym: "FT-0642456" EXACT [pubchem.compound:4592] synonym: "GTVPOLSIJWJJNY-UHFFFAOYSA-N" EXACT [pubchem.compound:4592] synonym: "HMS1362B11" EXACT [pubchem.compound:4592] synonym: "HMS1792B11" EXACT [pubchem.compound:4592] synonym: "HMS1990B11" EXACT [pubchem.compound:4592] synonym: "HMS3262B08" EXACT [pubchem.compound:4592] synonym: "HMS3267L09" EXACT [pubchem.compound:4592] synonym: "HMS3403B11" EXACT [pubchem.compound:4592] synonym: "HMS3650F19" EXACT [pubchem.compound:4592] synonym: "HMS3676E10" EXACT [pubchem.compound:4592] synonym: "IDI1_002090" EXACT [pubchem.compound:4592] synonym: "IN1179" EXACT [pubchem.compound:4592] synonym: "IN1182" EXACT [pubchem.compound:4592] synonym: "InSolution™ Olomoucine" EXACT [pubchem.compound:4592] synonym: "J-000453" EXACT [pubchem.compound:4592] synonym: "KB-162429" EXACT [pubchem.compound:4592] synonym: "KBio2_000330" EXACT [pubchem.compound:4592] synonym: "KBio2_002898" EXACT [pubchem.compound:4592] synonym: "KBio2_005466" EXACT [pubchem.compound:4592] synonym: "KBio3_000659" EXACT [pubchem.compound:4592] synonym: "KBio3_000660" EXACT [pubchem.compound:4592] synonym: "KBioGR_000330" EXACT [pubchem.compound:4592] synonym: "KBioSS_000330" EXACT [pubchem.compound:4592] synonym: "Kinome_2870" EXACT [pubchem.compound:4592] synonym: "LP00883" EXACT [pubchem.compound:4592] synonym: "Lopac-O-0886" EXACT [pubchem.compound:4592] synonym: "Lopac0_000883" EXACT [pubchem.compound:4592] synonym: "MFCD00189360" EXACT [pubchem.compound:4592] synonym: "MolPort-003-849-700" EXACT [pubchem.compound:4592] synonym: "NCGC00015763-01" EXACT [pubchem.compound:4592] synonym: "NCGC00015763-02" EXACT [pubchem.compound:4592] synonym: "NCGC00015763-03" EXACT [pubchem.compound:4592] synonym: "NCGC00015763-04" EXACT [pubchem.compound:4592] synonym: "NCGC00015763-05" EXACT [pubchem.compound:4592] synonym: "NCGC00015763-06" EXACT [pubchem.compound:4592] synonym: "NCGC00015763-07" EXACT [pubchem.compound:4592] synonym: "NCGC00015763-08" EXACT [pubchem.compound:4592] synonym: "NCGC00015763-09" EXACT [pubchem.compound:4592] synonym: "NCGC00025096-01" EXACT [pubchem.compound:4592] synonym: "NCGC00025096-02" EXACT [pubchem.compound:4592] synonym: "NCGC00025096-03" EXACT [pubchem.compound:4592] synonym: "NCGC00025096-04" EXACT [pubchem.compound:4592] synonym: "NCGC00025096-05" EXACT [pubchem.compound:4592] synonym: "NCGC00025096-06" EXACT [pubchem.compound:4592] synonym: "NCGC00025096-07" EXACT [pubchem.compound:4592] synonym: "NCGC00261568-01" EXACT [pubchem.compound:4592] synonym: "NCI60_022916" EXACT [pubchem.compound:4592] synonym: "NSC 666096" EXACT [pubchem.compound:4592] synonym: "NSC-666096" EXACT [pubchem.compound:4592] synonym: "NSC666096" EXACT [pubchem.compound:4592] synonym: "O 0886" EXACT [pubchem.compound:4592] synonym: "OLO" EXACT [pubchem.compound:4592] synonym: "Olomoucine, >=98% (HPLC)" EXACT [pubchem.compound:4592] synonym: "Olomucine" EXACT [pubchem.compound:4592] synonym: "RT-014854" EXACT [pubchem.compound:4592] synonym: "SCHEMBL135056" EXACT [pubchem.compound:4592] synonym: "SMP1_000281" EXACT [pubchem.compound:4592] synonym: "SR-01000075518" EXACT [pubchem.compound:4592] synonym: "SR-01000075518-1" EXACT [pubchem.compound:4592] synonym: "SR-01000075518-3" EXACT [pubchem.compound:4592] synonym: "SR-01000075518-6" EXACT [pubchem.compound:4592] synonym: "ST50298830" EXACT [pubchem.compound:4592] synonym: "TRA0035611" EXACT [pubchem.compound:4592] synonym: "Tocris-1284" EXACT [pubchem.compound:4592] synonym: "Tox21_500883" EXACT [pubchem.compound:4592] synonym: "UNII-6A839B2HYS" EXACT [pubchem.compound:4592] synonym: "UPCMLD-DP136" EXACT [pubchem.compound:4592] synonym: "UPCMLD-DP136:001" EXACT [pubchem.compound:4592] synonym: "UPCMLD-DP136:002" EXACT [pubchem.compound:4592] synonym: "ZINC1641925" EXACT [pubchem.compound:4592] synonym: "ZX-AFC001655" EXACT [pubchem.compound:4592] synonym: "olomoucine" EXACT [pubchem.compound:4592] synonym: "purine deriv. 5" EXACT [pubchem.compound:4592] [Term] id: CONSO:CONSO00284 name: oxazolidinedione namespace: chemical def: "Inhibitor of tau aggregation" [pubmed:26751493] xref: inchi:InChI=1S/C3H3NO3/c5-2-1-7-3\(6\)4-2/h1H2\,\(H\,4\,5\,6\) xref: pubchem.compound:97389 xref: smiles:C1C\(=O\)NC\(=O\)O1 relationship: ro:0000087 CONSO:CONSO00321 relationship: CONSO:author orcid:0000-0001-9661-5277 synonym: "1,3-oxazolidin-2,4-dione" EXACT [pubchem.compound:97389] synonym: "1,3-oxazolidine-2,4-dione" EXACT [pubchem.compound:97389] synonym: "12770-97-7" EXACT [pubchem.compound:97389] synonym: "153301-EP2281822A1" EXACT [pubchem.compound:97389] synonym: "1572AB" EXACT [pubchem.compound:97389] synonym: "2,4-Oxazolidenedione" EXACT [pubchem.compound:97389] synonym: "2,4-Oxazolidinedione" EXACT [pubchem.compound:97389] synonym: "2,4oxazolidinedione" EXACT [pubchem.compound:97389] synonym: "2346-26-1" EXACT [pubchem.compound:97389] synonym: "346O261" EXACT [pubchem.compound:97389] synonym: "A816734" EXACT [pubchem.compound:97389] synonym: "AC1L3YF0" EXACT [pubchem.compound:97389] synonym: "AJ-30743" EXACT [pubchem.compound:97389] synonym: "AK-80133" EXACT [pubchem.compound:97389] synonym: "AKOS002529400" EXACT [pubchem.compound:97389] synonym: "AN-50728" EXACT [pubchem.compound:97389] synonym: "ANW-57979" EXACT [pubchem.compound:97389] synonym: "CJ-28984" EXACT [pubchem.compound:97389] synonym: "CMLDBU00003511" EXACT [pubchem.compound:97389] synonym: "COWNFYYYZFRNOY-UHFFFAOYSA-N" EXACT [pubchem.compound:97389] synonym: "CTK0H9315" EXACT [pubchem.compound:97389] synonym: "DA-18172" EXACT [pubchem.compound:97389] synonym: "DS-15871" EXACT [pubchem.compound:97389] synonym: "F2167-1227" EXACT [pubchem.compound:97389] synonym: "FT-0704394" EXACT [pubchem.compound:97389] synonym: "KB-67472" EXACT [pubchem.compound:97389] synonym: "KS-00000MOC" EXACT [pubchem.compound:97389] synonym: "MFCD02691902" EXACT [pubchem.compound:97389] synonym: "MolPort-018-280-326" EXACT [pubchem.compound:97389] synonym: "NSC 120350" EXACT [pubchem.compound:97389] synonym: "NSC-120350" EXACT [pubchem.compound:97389] synonym: "NSC120350" EXACT [pubchem.compound:97389] synonym: "OXAZOLIDINE-2,4-DIONE" EXACT [pubchem.compound:97389] synonym: "Oxazolidinedione" EXACT [pubchem.compound:97389] synonym: "R22D15229R" EXACT [pubchem.compound:97389] synonym: "SC-49693" EXACT [pubchem.compound:97389] synonym: "SCHEMBL123971" EXACT [pubchem.compound:97389] synonym: "SCHEMBL1395587" EXACT [pubchem.compound:97389] synonym: "SCHEMBL8159833" EXACT [pubchem.compound:97389] synonym: "TC-146724" EXACT [pubchem.compound:97389] synonym: "UNII-R22D15229R" EXACT [pubchem.compound:97389] synonym: "Z56762271" EXACT [pubchem.compound:97389] synonym: "ZINC1709820" EXACT [pubchem.compound:97389] synonym: "hydroxyoxazolinone" EXACT [pubchem.compound:97389] [Term] id: CONSO:CONSO00285 name: sudoxicam namespace: chemical def: "Inhibitor of tau aggregation" [pubmed:26751493] xref: cas:34042-85-8 xref: inchi:InChI=1S/C13H11N3O4S2/c1-16-10\(12\(18\)15-13-14-6-7-21-13\)11\(17\)8-4-2-3-5-9\(8\)22\(16\,19\)20/h2-7\,17H\,1H3\,\(H\,14\,15\,18\) xref: pubchem.compound:54682951 xref: smiles:CN1C\(=C\(C2=CC=CC=C2S1\(=O\)=O\)O\)C\(=O\)NC3=NC=CS3 relationship: ro:0000087 CONSO:CONSO00321 relationship: CONSO:author orcid:0000-0001-9661-5277 synonym: "(3E)-3-[hydroxy-(1,3-thiazol-2-ylamino)methylidene]-2-methyl-1,1-dioxo-1" EXACT [pubchem.compound:54682951] synonym: "(3Z)-3-[hydroxy-(1,3-thiazol-2-ylamino)methylidene]-2-methyl-1,1-dioxo-1" EXACT [pubchem.compound:54682951] synonym: "2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-thiazolyl-, 1,1-dioxide" EXACT [pubchem.compound:54682951] synonym: "3-[hydroxy-(1,3-thiazol-2-ylamino)methylidene]-2-methyl-1,1-dioxo-1" EXACT [pubchem.compound:54682951] synonym: "34042-85-8" EXACT [pubchem.compound:54682951] synonym: "4-Hydroxy-2-methyl-N-(1,3-thiazol-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide" EXACT [pubchem.compound:54682951] synonym: "4-Hydroxy-2-methyl-N-1,3-thiazol-2-yl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide" EXACT [pubchem.compound:54682951] synonym: "4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide" EXACT [pubchem.compound:54682951] synonym: "4-hydroxy-2-methyl-1,1-dioxo-N-thiazol-2-yl-1$l^{6},2-benzothiazine-3-carboxamide" EXACT [pubchem.compound:54682951] synonym: "4-hydroxy-2-methyl-N-(2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide" EXACT [pubchem.compound:54682951] synonym: "AC1L1W79" EXACT [pubchem.compound:54682951] synonym: "AC1NSEW2" EXACT [pubchem.compound:54682951] synonym: "AC1NSM46" EXACT [pubchem.compound:54682951] synonym: "ACM34042858" EXACT [pubchem.compound:54682951] synonym: "AKOS030239604" EXACT [pubchem.compound:54682951] synonym: "BRN 0628704" EXACT [pubchem.compound:54682951] synonym: "CHEMBL20634" EXACT [pubchem.compound:54682951] synonym: "CP 15973" EXACT [pubchem.compound:54682951] synonym: "CP-15,973" EXACT [pubchem.compound:54682951] synonym: "CP-15973" EXACT [pubchem.compound:54682951] synonym: "CTK8G3246" EXACT [pubchem.compound:54682951] synonym: "D05937" EXACT [pubchem.compound:54682951] synonym: "DTXSID50187653" EXACT [pubchem.compound:54682951] synonym: "EINECS 251-808-7" EXACT [pubchem.compound:54682951] synonym: "FT-0674694" EXACT [pubchem.compound:54682951] synonym: "J-019435" EXACT [pubchem.compound:54682951] synonym: "LS-40541" EXACT [pubchem.compound:54682951] synonym: "MLS006010801" EXACT [pubchem.compound:54682951] synonym: "N-(2-Thiazolyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-Dioxide" EXACT [pubchem.compound:54682951] synonym: "NSC 615046" EXACT [pubchem.compound:54682951] synonym: "NSC-615046" EXACT [pubchem.compound:54682951] synonym: "NSC615046" EXACT [pubchem.compound:54682951] synonym: "Oprea1_704902" EXACT [pubchem.compound:54682951] synonym: "SCHEMBL35067" EXACT [pubchem.compound:54682951] synonym: "SCHEMBL35068" EXACT [pubchem.compound:54682951] synonym: "SMR004701482" EXACT [pubchem.compound:54682951] synonym: "SUDOXICAM" EXACT [pubchem.compound:54682951] synonym: "SYCHUQUJURZQMO-UHFFFAOYSA-N" EXACT [pubchem.compound:54682951] synonym: "Sudoxicam (USAN/INN)" EXACT [pubchem.compound:54682951] synonym: "Sudoxicam [USAN:BAN:INN]" EXACT [pubchem.compound:54682951] synonym: "Sudoxicam [USAN:INN:BAN]" EXACT [pubchem.compound:54682951] synonym: "Sudoxicamum" EXACT [pubchem.compound:54682951] synonym: "Sudoxicamum [INN-Latin]" EXACT [pubchem.compound:54682951] synonym: "UNII-X033PDI962" EXACT [pubchem.compound:54682951] synonym: "X033PDI962" EXACT [pubchem.compound:54682951] synonym: "ZINC5699183" EXACT [pubchem.compound:54682951] [Term] id: CONSO:CONSO00286 name: thiohydantoin namespace: chemical def: "Inhibitor of tau aggregation" [pubmed:26751493] xref: chembl:CHEMBL1958109 xref: chemspider:1069421 xref: inchi:InChI=1S/C3H4N2OS/c6-2-1-4-3\(7\)5-2/h1H2\,\(H2\,4\,5\,6\,7\) xref: smiles:O=C1CNC\(=S\)N1 relationship: ro:0000087 CONSO:CONSO00321 relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00287 name: thioxooxazolidine namespace: chemical def: "Inhibitor of tau aggregation" [pubmed:26751493] relationship: ro:0000087 CONSO:CONSO00321 relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00288 name: tideglusib namespace: chemical def: "Irreversibly inhibits GSK3B activity" [pubmed:22102280] xref: inchi:InChI=1S/C19H14N2O2S/c22-18-20\(13-14-7-2-1-3-8-14\)19\(23\)24-21\(18\)17-12-6-10-15-9-4-5-11-16\(15\)17/h1-12H\,13H2 xref: pubchem.compound:11313622 xref: smiles:O=C3SN\(c1cccc2c1cccc2\)C\(=O\)N3Cc4ccccc4 relationship: CONSO:author orcid:0000-0001-9661-5277 synonym: "1,2,4-Thiadiazolidine-3,5-dione, 2-(1-naphthalenyl)-4-(phenylmethyl)-" EXACT [pubchem.compound:11313622] synonym: "4-Benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione" EXACT [pubchem.compound:11313622] synonym: "4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione" EXACT [pubchem.compound:11313622] synonym: "4-benzyl-2-(naphthalen-1-yl)-(1,2,4)thiadiazolidine-3,5-dione" EXACT [pubchem.compound:11313622] synonym: "4-benzyl-2-naphthalen-1-yl-1,2,4-thiadiazolidine-3,5-dione" EXACT [pubchem.compound:11313622] synonym: "4CA-1249" EXACT [pubchem.compound:11313622] synonym: "865854-05-3" EXACT [pubchem.compound:11313622] synonym: "AK176015" EXACT [pubchem.compound:11313622] synonym: "AKOS025149085" EXACT [pubchem.compound:11313622] synonym: "AOB5562" EXACT [pubchem.compound:11313622] synonym: "BC600768" EXACT [pubchem.compound:11313622] synonym: "BCP06016" EXACT [pubchem.compound:11313622] synonym: "BDBM50166940" EXACT [pubchem.compound:11313622] synonym: "C19H14N2O2S" EXACT [pubchem.compound:11313622] synonym: "CHEMBL3545157" EXACT [pubchem.compound:11313622] synonym: "CS-0613" EXACT [pubchem.compound:11313622] synonym: "D0UT7X" EXACT [pubchem.compound:11313622] synonym: "DA-41071" EXACT [pubchem.compound:11313622] synonym: "DB12129" EXACT [pubchem.compound:11313622] synonym: "DTXSID90235682" EXACT [pubchem.compound:11313622] synonym: "EX-A600" EXACT [pubchem.compound:11313622] synonym: "FT-0700382" EXACT [pubchem.compound:11313622] synonym: "GTPL6929" EXACT [pubchem.compound:11313622] synonym: "HY-14872" EXACT [pubchem.compound:11313622] synonym: "J-514478" EXACT [pubchem.compound:11313622] synonym: "KB-81154" EXACT [pubchem.compound:11313622] synonym: "MFCD18633296" EXACT [pubchem.compound:11313622] synonym: "MolPort-028-599-952" EXACT [pubchem.compound:11313622] synonym: "NP 031112" EXACT [pubchem.compound:11313622] synonym: "NP-031112" EXACT [pubchem.compound:11313622] synonym: "NP-031112|||4-Benzyl-2-naphthalen-1-yl-1,2,4-thiadiazolidine-3,5-dione" EXACT [pubchem.compound:11313622] synonym: "NP-12" EXACT [pubchem.compound:11313622] synonym: "NP031112" EXACT [pubchem.compound:11313622] synonym: "Q747Y6TT42" EXACT [pubchem.compound:11313622] synonym: "RL05359" EXACT [pubchem.compound:11313622] synonym: "SB19268" EXACT [pubchem.compound:11313622] synonym: "SCHEMBL676929" EXACT [pubchem.compound:11313622] synonym: "Tideglusib" EXACT [pubchem.compound:11313622] synonym: "Tideglusib (NP031112, NP-12)" EXACT [pubchem.compound:11313622] synonym: "Tideglusib [INN]" EXACT [pubchem.compound:11313622] synonym: "Tideglusib(NP-031112)" EXACT [pubchem.compound:11313622] synonym: "Tideglusib, >=98% (HPLC)" EXACT [pubchem.compound:11313622] synonym: "Tideglusib,CAS:865854-05-3" EXACT [pubchem.compound:11313622] synonym: "UNII-Q747Y6TT42" EXACT [pubchem.compound:11313622] synonym: "W-5777" EXACT [pubchem.compound:11313622] synonym: "X5395" EXACT [pubchem.compound:11313622] synonym: "ZINC13985228" EXACT [pubchem.compound:11313622] synonym: "s2823" EXACT [pubchem.compound:11313622] [Term] id: CONSO:CONSO00289 name: Tau antibody, 6C5 namespace: antibody def: "human monoclonal antibody that targets tau epitope 125-131" [pubmed:28408124] is_a: CONSO:CONSO00307 ! Tau antibody relationship: CONSO:has_antibody_target HGNC:6893 relationship: CONSO:author orcid:0000-0002-3034-9970 [Term] id: CONSO:CONSO00290 name: Tau antibody, HT7 namespace: antibody def: "mouse monoclonal antibody that targets tau epitope 159-163" [pubmed:28408124] is_a: CONSO:CONSO00307 ! Tau antibody relationship: CONSO:author orcid:0000-0002-3034-9970 [Term] id: CONSO:CONSO00291 name: 6-O-sulfated heparin def: "During synthesis the HS chains are selectively sulfated at the N, 6-O, and 3-O positions of the glucosamine (GlcNS) and at the 2-O position of the uronic acid residue by HS sulfotransferases and modified by C5-epimerization of glucuronic acid (GlcA) to iduronic acid (IdoA)" [pubmed:24878958] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00292 name: 2-O-sulfated heparin def: "During synthesis the HS chains are selectively sulfated at the N, 6-O, and 3-O positions of the glucosamine (GlcNS) and at the 2-O position of the uronic acid residue by HS sulfotransferases and modified by C5-epimerization of glucuronic acid (GlcA) to iduronic acid (IdoA)" [pubmed:24878958] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00293 name: sonicated tau fibrils namespace: cellular_component def: "To make sonicated fibril samples, fibrillized protein was sonicated using a MiSonix Sonicator 4000 (QSonica, LLC) at 50% amplitude for 60 1 s pulses" [pubmed:29686391] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00294 name: Tau antibody, 40E8 namespace: antibody def: "human monoclonal antibody that targets tau epitope 195-212 (pS202 and pT205)" [pubmed:28408124] is_a: CONSO:CONSO00307 ! Tau antibody relationship: CONSO:author orcid:0000-0002-3034-9970 [Term] id: CONSO:CONSO00295 name: Tau antibody, pS396 namespace: antibody def: "rabbit polyclonal antibody that targets tau pS396" [pubmed:28408124] is_a: CONSO:CONSO00307 ! Tau antibody relationship: CONSO:author orcid:0000-0002-3034-9970 [Term] id: CONSO:CONSO00296 name: Tau antibody, 4E4 namespace: antibody def: "human monoclonal antibody that targets tau epitope 385-395" [pubmed:28408124] is_a: CONSO:CONSO00307 ! Tau antibody relationship: CONSO:has_antibody_target HGNC:6893 relationship: CONSO:author orcid:0000-0002-3034-9970 [Term] id: CONSO:CONSO00297 name: Tau antibody, Tau46 namespace: antibody def: "mouse monoclonal antibody that targets tau epitope 404-441" [pubmed:28408124] is_a: CONSO:CONSO00307 ! Tau antibody relationship: CONSO:has_antibody_target MGI:MGI:97180 relationship: CONSO:author orcid:0000-0002-3034-9970 [Term] id: CONSO:CONSO00298 name: cis p-tau namespace: protein def: "The cis conformation of phosphorylated tau is considered to be the main pathogenic tau agent associated with AD neurological impairments. PIN1, a peptidyl-prolyl-cis-transe isomerase, catalizes the rotation of the peptidic bond directly before proline residues inducing a conversion toward the trans conformation, therefore reducing the presence of the pathogenic cis tau isomers." [pubmed:23157676, pubmed:25628064] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00299 name: MPT0G211 namespace: chemical def: "MPT0G211 is a novel potent, selective HDAC6 inhibitor with IC50 of 0.291 nM, displays >1,000-fold selectivity over other HDAC isoforms; significantly inhibits tau phosphorylation on Ser396, Ser404, and phosphorylated tau (p-tau) aggregation, significantly attenuates apoptosis induced by p-tau, inhibits HDAC6/Hsp90 binding and causes subsequent proteasomal degradation of polyubiquitinated proteins; ameliorates learning and memory impairment in animal models of Alzheimer's disease, reduces the amount of phosphorylated tau in the hippocampal CA1 region; also demonstrates antiproliferative activity against human multiple myeloma RPMI 8226, U266, and NCI-H929 cells with no effect on normal bone marrow cells." [pubmed:29844403] xref: cas:2151853-97-1 xref: inchi:InChI=1S/C17H15N3O2/c21-17\(20-22\)14-8-6-12\(7-9-14\)11-19-15-5-1-3-13-4-2-10-18-16\(13\)15/h1-10\,19\,22H\,11H2\,\(H\,20\,21\) xref: smiles:C1=CC\(=CC=C1CNC2=CC=CC3=C2N=CC=C3\)C\(=O\)NC relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00300 name: peripheral nervous system injury namespace: pathology def: "PNS injuries initiate a signaling cascade that induces neuroregeneration. This cascade involves activation of ERK, subsequently leading to the activation of PCAF (KAT2B), which in turn mediates histone 3 acetylation, paving the way for transcriptional activation of the key genes in the regeneration program." [pubmed:24686445] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00301 name: Tau antibody, TNT1 namespace: antibody def: "Murine monoclonal IgG recognizing the phosphatase-activating domain (PAD) of tau" [pubmed:27260838] is_a: CONSO:CONSO00307 ! Tau antibody relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00302 name: Tau antibody, TNT2 namespace: antibody def: "Murine monoclonal IgG recognizing the phosphatase-activating domain (PAD) of tau" [pubmed:27260838] is_a: CONSO:CONSO00307 ! Tau antibody relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00303 name: 8-nitro-cGMP namespace: chemical def: "One of the major endogenus cGMP derivatives, a class of second messengers in the nitric oxide signalling pathway. It modifies the target protein's cysteine residues via a stable sulfide bond through the NO group of the guanine base, in a post translational modification also known as S-guanylation, a process involved in the regulation of the physiological roles of several important proteins. The S-guanylation of tau was shown to block the aggregation process and the subsequent formation of tau oligomers." [pubmed:28213625, pubmed:27601475] xref: chebi:136665 xref: inchi:InChI=1S/C10H11N6O9P/c11-9-13-6-3\(7\(18\)14-9\)12-10\(16\(19\)20\)15\(6\)8-4\(17\)5-2\(24-8\)1-23-26\(21\,22\)25-5/h2\,4-5\,8\,17H\,1H2\,\(H\,21\,22\)\(H3\,11\,13\,14\,18\)/t2-\,4-\,5-\,8-/m1/s1 xref: smiles:N1C\(=NC2=C\(N=C\(N2\[C@@H\]3O\[C@@H\]4COP\(O\[C@H\]4\[C@H\]3O\)\(=O\)O\)\[N+\]\(\[O-\]\)=O\)C1=O\)N relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00304 name: Tau dimers namespace: cellular_component def: "A key intermediate product of tau oligomerization to PHF and NFT formation, they consist of covalently linked antiparallel tau monomers presenting disulfide cross links between cystein residues." [pubmed:27373205, pubmed:10899437] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00305 name: polysumoylation namespace: post_translational_modification def: "A post-translational modification consisting on the addition and covalent bonding of multiple SUMO (small ubiquitin-like modifiers) proteins to lysine residues of target proteins, mediating a wide range of physiological functions. Polysumoylation of APP was found to reduce the generation of amyloid beta peptides, while mono or under-sumoylation enhance Ab generation." [pubmed:12506199] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00306 name: detyrosination namespace: post_translational_modification def: "Detyrosination is a form of posttranslational modification that occurs on alpha-tubulin. It consists of the removal of the C-terminal tyrosine to expose a glutamate at the newly formed C-terminus." [pubmed:25974414] relationship: CONSO:author orcid:0000-0001-9661-5277 [Term] id: CONSO:CONSO00307 name: Tau antibody namespace: antibody def: "Antibodies for the Tau protein (HGNC:MAPT)" [pubmed:28408124, pubmed:27260838, pubmed:26751493, pubmed:23666762, pubmed:23666762] relationship: CONSO:author orcid:0000-0003-4423-4370 [Term] id: CONSO:CONSO00308 name: Tau epitope namespace: epitope def: "Epitopes targed by antibodies for the Tau protein (HGNC:MAPT)" [pubmed:28408124, pubmed:27260838, pubmed:26751493, pubmed:23666762, pubmed:23666762] relationship: CONSO:author orcid:0000-0003-4423-4370 [Term] id: CONSO:CONSO00309 name: S 24795 namespace: chemical def: "A partial agonist at α7 nAChR" [pubmed:18187166, pubmed:18265960, pubmed:18034231] xref: chemspider:8063920 xref: inchi:InChI=1S/C14H13BrNO.HI/c1-16-9-3-2-4-13\(16\)10-14\(17\)11-5-7-12\(15\)8-6-11;/h2-9H\,10H2\,1H3;1H/q+1;/p-1 xref: pubchem.compound:9888248 xref: smiles:C\[N+\]1=CC=CC=C1CC\(=O\)C2=CC=C\(C=C2\)Br.\[I-\] relationship: CONSO:author orcid:0000-0003-4423-4370 synonym: "2-[2-(4-Bromophenyl)-2-oxoethyl]-1-methylpyridinium iodide" EXACT [] synonym: "2-[2-(4-Bromophenyl)-2-oxoethyl]-1-methylpyridinium iodide" EXACT [pubchem.compound:9888248] synonym: "2-[2-(4-bromophenyl)-2-oxoethyl]-1-methylpyridiniumiodide" EXACT [pubchem.compound:9888248] synonym: "304679-75-2" EXACT [pubchem.compound:9888248] synonym: "AKOS024457657" EXACT [pubchem.compound:9888248] synonym: "API0014115" EXACT [pubchem.compound:9888248] synonym: "KB-80442" EXACT [pubchem.compound:9888248] synonym: "LERUHBBUGAOYOD-UHFFFAOYSA-M" EXACT [pubchem.compound:9888248] synonym: "MolPort-023-276-831" EXACT [pubchem.compound:9888248] synonym: "S 24795" EXACT [pubchem.compound:9888248] synonym: "S 24795, >=98% (HPLC)" EXACT [pubchem.compound:9888248] synonym: "SCHEMBL5948853" EXACT [pubchem.compound:9888248] [Term] id: CONSO:CONSO00310 name: GTS-21 namespace: chemical def: "GTS-21 is a derivative of the natural product anabaseine that acts as a partial agonist at neural nicotinic acetylcholine receptors. It binds to both the α4β2 and α7 subtypes, but activates only the α7 to any significant extent." [pubmed:25514383] xref: chemspider:4470526 xref: drugbank:DB05708 xref: inchi:InChI=1S/C19H20N2O2/c1-22-17-8-7-14\(18\(12-17\)23-2\)11-15-5-4-10-21-19\(15\)16-6-3-9-20-13-16/h3\,6-9\,11-13H\,4-5\,10H2\,1-2H3/b15-11+ xref: pubchem.compound:5310985 xref: smiles:\[H\]\\C\(=C1\\CCCN=C1C1=CN=CC=C1\)C1=C\(OC\)C=C\(OC\)C=C1 relationship: CONSO:author orcid:0000-0003-4423-4370 synonym: "(3E)-3-(2,4-dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine" EXACT [pubchem.compound:5310985] synonym: "(3E)-3-[(2,4-DIMETHOXYPHENYL)METHYLIDENE]-3,4,5,6-TETRAHYDRO-2,3''-BIPYRIDINE" EXACT [pubchem.compound:5310985] synonym: "(3e)-3-[(2,4-Dimethoxyphenyl)methylidene]-3,4,5,6-Tetrahydro-2,3'-Bipyridine" EXACT [pubchem.compound:5310985] synonym: "148372-04-7" EXACT [pubchem.compound:5310985] synonym: "2,3'-Bipyridine, 3-((2,4-dimethoxyphenyl)methylene)-3,4,5,6-tetrahydro-, (3E)-" EXACT [pubchem.compound:5310985] synonym: "2,3'-Bipyridine, 3-[(2,4-dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-, hydrochloride (1:2), (3E)-" EXACT [pubchem.compound:5310985] synonym: "2,4-Dimethoxybenzylidene anabaseine" EXACT [pubchem.compound:5310985] synonym: "2wnj" EXACT [pubchem.compound:5310985] synonym: "3 (2,4 dimethoxybenzylidene)anabaseine" EXACT [pubchem.compound:5310985] synonym: "3,4,5,6-Tetrahydro-3-(2,4-dimethoxybenzylidene)-2,3'-bipyridine" EXACT [pubchem.compound:5310985] synonym: "3-(2,4-Dimethoxy-benzylidene)-3,4,5,6-tetrahydro-[2,3']bipyridinyl" EXACT [pubchem.compound:5310985] synonym: "3-(2,4-Dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine" EXACT [pubchem.compound:5310985] synonym: "3-(2,4-dimethoxybenzylidene)anabaseine" EXACT [pubchem.compound:5310985] synonym: "3-(3-(2,4-dimethoxybenzylidene)-3,4,5,6-tetrahydropyridin-2-yl)pyridine" EXACT [pubchem.compound:5310985] synonym: "3-(4-hydroxy-2-methoxybenzylidene)anabaseine" EXACT [pubmed:25514383] synonym: "3-[(2,4-dimethoxy)benzylidene]-anabaseine" EXACT [pubchem.compound:5310985] synonym: "3-[(2,4-dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-2,3'-Bipyridine" EXACT [pubchem.compound:5310985] synonym: "3-[(3E)-3-[(2,4-DIMETHOXYPHENYL)METHYLIDENE]-5,6-DIHYDRO-4H-PYRIDIN-2-YL]PYRIDINE" EXACT [pubchem.compound:5310985] synonym: "3-[(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-3,4,5,6-tetrahydropyridin-2-yl]pyridine" EXACT [drugbank:DB05708] synonym: "3-[(5E)-5-[(2,4-dimethoxyphenyl)methylidene]-3,4-dihydro-2H-pyridin-6-yl]pyridine" EXACT [pubchem.compound:5310985] synonym: "3-[(E)-(2,4-Dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-2,3'-bipyridine" EXACT [pubchem.compound:5310985] synonym: "3-[1-(2,4-Dimethoxy-phenyl)-meth-(E)-ylidene]-3,4,5,6-tetrahydro-[2,3'']bipyridinyl" EXACT [pubchem.compound:5310985] synonym: "419A471" EXACT [pubchem.compound:5310985] synonym: "8S399XDN2K" EXACT [pubchem.compound:5310985] synonym: "A15950" EXACT [pubchem.compound:5310985] synonym: "AC1NSJRW" EXACT [pubchem.compound:5310985] synonym: "AKOS005146470" EXACT [pubchem.compound:5310985] synonym: "ASIS-0106" EXACT [pubchem.compound:5310985] synonym: "BBL035625" EXACT [pubchem.compound:5310985] synonym: "BDBM50061564" EXACT [pubchem.compound:5310985] synonym: "BDBM86543" EXACT [pubchem.compound:5310985] synonym: "C19905" EXACT [pubchem.compound:5310985] synonym: "CAS_156223-05-1" EXACT [pubchem.compound:5310985] synonym: "CHEMBL134713" EXACT [pubchem.compound:5310985] synonym: "DB05708" EXACT [pubchem.compound:5310985] synonym: "DMXB-A" EXACT [pubchem.compound:5310985] synonym: "Dimethoxybenzylidene anabaseine" EXACT [pubchem.compound:5310985] synonym: "GTS 21" EXACT [pubmed:25514383] synonym: "GTS-21" EXACT [drugbank:DB05708] synonym: "Gts-21" EXACT [pubchem.compound:5310985] synonym: "KB-77635" EXACT [pubchem.compound:5310985] synonym: "MolPort-004-975-791" EXACT [pubchem.compound:5310985] synonym: "NSC_122225" EXACT [pubchem.compound:5310985] synonym: "SCHEMBL316745" EXACT [pubchem.compound:5310985] synonym: "SCHEMBL316746" EXACT [pubchem.compound:5310985] synonym: "STL441849" EXACT [pubchem.compound:5310985] synonym: "UNII-8S399XDN2K" EXACT [pubchem.compound:5310985] synonym: "X5074" EXACT [pubchem.compound:5310985] synonym: "X5075" EXACT [pubchem.compound:5310985] synonym: "ZINC860" EXACT [pubchem.compound:5310985] [Term] id: CONSO:CONSO00311 name: alpha-4 alpha-5 beta-2 nAChR namespace: protein_complex def: "nAChR subtype found in cortex, hippocampus and neostriatum" [pubmed:19721446] relationship: CONSO:author orcid:0000-0002-3034-9970 property_value: bel "complex(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2))" xsd:string [Term] id: CONSO:CONSO00312 name: alpha-3 beta-4 nAChR namespace: protein_complex def: "nAChR subtype found in hippocampus, pineal gland and cerebellum" [pubmed:19721446] relationship: CONSO:author orcid:0000-0002-3034-9970 property_value: bel "complex(p(HGNC:CHRNA3), p(HGNC:CHRNB4))" xsd:string [Term] id: CONSO:CONSO00313 name: alpha-3 beta-3 beta-4 nAChR namespace: protein_complex def: "nAChR subtype found in habenula and interpeduncular nucleus" [pubmed:19721446] relationship: CONSO:author orcid:0000-0002-3034-9970 [Term] id: CONSO:CONSO00314 name: alpha-6 beta-2 beta-3 nAChR namespace: protein_complex def: "nAChR subtype found in locus coeruleus, substantia nigra and neostriatum" [pubmed:19721446] relationship: CONSO:author orcid:0000-0002-3034-9970 [Term] id: CONSO:CONSO00315 name: alpha-2 beta-2 nAChR namespace: protein_complex def: "nAChR subtype found in interpeduncular nucleus" [pubmed:19721446] relationship: CONSO:author orcid:0000-0002-3034-9970 [Term] id: CONSO:CONSO00316 name: alpha-6 alpha-4 beta-2 beta-3 nAChR namespace: protein_complex def: "nAChR subtype found in neostriatum" [pubmed:19721446] relationship: CONSO:author orcid:0000-0002-3034-9970 [Term] id: CONSO:CONSO00317 name: protein aggregation namespace: biological_process def: "Protein aggregation occurs in vivo as a result of improper folding or misfolding" [pubmed:11831622] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00318 name: nAChR assembly namespace: biological_process def: "the process of assembling a receptor pentamer from the Nicotinic acetylcholine receptors subunits" [pubmed:19126755] relationship: CONSO:author orcid:0000-0002-3034-9970 [Term] id: CONSO:CONSO00319 name: 4-OH-GTS-21 namespace: chemical def: "A metabolic product of GTS-21 (HBP:CONSO00310) in which the methoxy at the 4-position has been cleaved to leave a hydroxyl" [pubmed:25514383] xref: inchi:InChI=1S/C18H18N2O2/c1-22-17-11-16\(21\)7-6-13\(17\)10-14-4-3-9-20-18\(14\)15-5-2-8-19-12-15/h2\,5-8\,10-12\,21H\,3-4\,9H2\,1H3/b14-10+ xref: mesh:C116666 xref: smiles:COC1=C\(C=CC\(=C1\)O\)C=C2CCCN=C2C3=CC=CN=C3 relationship: CONSO:author orcid:0000-0003-4423-4370 synonym: "3-(4-hydroxy-2-methoxybenzylidene) anabaseine" EXACT [pubmed:25514383] synonym: "3-(4-hydroxy-2-methoxybenzylidene)anabaseine" EXACT [pubmed:25514383] synonym: "4OH-GTS-21" EXACT [mesh:C116666] [Term] id: CONSO:CONSO00320 name: isolation rearing namespace: exposure def: "An animal model in which rats, immediately after weaning (usually postnatal day 21), are housed in isolation from siblings for an extended period (usually several weeks). In adulthood, these animals show many characteristics also seen in patients with schizophrenia" [pubmed:16820021] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00321 name: Tau aggregation inhibitor namespace: chemical_role def: "A chemical that inhibits the aggregation of the Tau protein (HGNC:MAPT) as form paired helical fragments (PHFs), straight filaments (SFs), oligomers, and larger aggregates" [pubmed:23484434] xref: chebi:142738 relationship: CONSO:author orcid:0000-0003-4423-4370 [Term] id: CONSO:CONSO00322 name: 1,3-Thiazole-2,4-diamine namespace: chemical def: "A thiazole with two amino substituents" [pubmed:21353545, pubmed:20524425, pubmed:11148059] xref: inchi:InChI=1S/C3H5N3S/c4-2-1-7-3\(5\)6-2/h1H\,4H2\,\(H2\,5\,6\) xref: pubchem.compound:118995 xref: smiles:C1=C\(N=C\(S1\)N\)N relationship: CONSO:author orcid:0000-0003-4423-4370 synonym: "1,3-thiazole-2,4-diamine" EXACT [pubchem.compound:118995] synonym: "2,4-thiazolediamine" EXACT [pubchem.compound:118995] synonym: "67355-26-4" EXACT [pubchem.compound:118995] synonym: "AB0070905" EXACT [pubchem.compound:118995] synonym: "AB00987320-01" EXACT [pubchem.compound:118995] synonym: "AC1L3O08" EXACT [pubchem.compound:118995] synonym: "AC1Q4VRF" EXACT [pubchem.compound:118995] synonym: "AJ-67953" EXACT [pubchem.compound:118995] synonym: "AK-30756" EXACT [pubchem.compound:118995] synonym: "AKOS009092919" EXACT [pubchem.compound:118995] synonym: "ANW-58036" EXACT [pubchem.compound:118995] synonym: "BS-12711" EXACT [pubchem.compound:118995] synonym: "F2145-0277" EXACT [pubchem.compound:118995] synonym: "FT-0707053" EXACT [pubchem.compound:118995] synonym: "KB-261000" EXACT [pubchem.compound:118995] synonym: "M-8345" EXACT [pubchem.compound:118995] synonym: "MCULE-4736308679" EXACT [pubchem.compound:118995] synonym: "MFCD06738274" EXACT [pubchem.compound:118995] synonym: "MolPort-002-471-220" EXACT [pubchem.compound:118995] synonym: "QC-6319" EXACT [pubchem.compound:118995] synonym: "SCHEMBL461605" EXACT [pubchem.compound:118995] synonym: "ST24031901" EXACT [pubchem.compound:118995] synonym: "TC-146781" EXACT [pubchem.compound:118995] synonym: "Thiazole-2,4-diamine" EXACT [pubchem.compound:118995] synonym: "Z5019" EXACT [pubchem.compound:118995] synonym: "ZINC15863137" EXACT [pubchem.compound:118995] synonym: "diaminothiazole" EXACT [pubchem.compound:118995] [Term] id: CONSO:CONSO00323 name: Autosomal Dominant Nocturnal Frontal Lobe Epilepsy namespace: pathology def: "Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is a genetic form of epilepsy that is caused by mutations in several genes, including genes encoding for the α4 and β2 subunits of the nicotinic acetylcholine (nACh) receptor" [pubmed:30472464] xref: doid:0060681 xref: mesh:C579932 relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00324 name: FK1 antibody namespace: antibody def: "Anti-Ubiquitinylated proteins Antibod" [pubmed:16338350] relationship: CONSO:author orcid:0000-0002-3034-9970 [Term] id: CONSO:CONSO00325 name: amyloid-beta antibody, NU1 namespace: antibody def: "monoclonal antibody that is specific for amyloid-beta oligomers" [pubmed:17403556] relationship: CONSO:author orcid:0000-0002-3034-9970 [Term] id: CONSO:CONSO00326 name: B-973 namespace: chemical def: "Here we report the discovery and characterization of 3-(3,4-difluorophenyl)-N-(1-(6-(4-(pyridin-2-yl)piperazin-1-yl)pyrazin-2-yl)ethyl)propanamide (B-973), a piperazine containing α7 type II PAM" [pubmed:28132910] xref: inchi:InChI=1S/C24H26F2N6O/c1-17\(29-24\(33\)8-6-18-5-7-19\(25\)20\(26\)14-18\)21-15-27-16-23\(30-21\)32-12-10-31\(11-13-32\)22-4-2-3-9-28-22/h2-5\,7\,9\,14-17H\,6\,8\,10-13H2\,1H3\,\(H\,29\,33\)/t17-/m0/s1 xref: smiles:C1=C\(C\(=CC=C1CCC\(N\[C@H\]\(C2=CN=CC\(=N2\)N3CCN\(CC3\)C4=NC=CC=C4\)C\)=O\)F\)F relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00327 name: GPBC, alpha-7 nAChR namespace: domain def: "An alignment of residues in the M3-M4 loop of alpha-7 nAChR that contribute to the binding of G-protein" [pubmed:24185813, pubmed:26088141] relationship: CONSO:author orcid:0000-0002-3034-9970 [Term] id: CONSO:CONSO00328 name: GPBC, Glycine Receptor 1 namespace: domain def: "An alignment of residues in the M3-M4 loop of GPBC, Glycine Receptor 1 (GLRA1) that contribute to the binding of G-protein" [pubmed:24185813, pubmed:26088141] relationship: CONSO:author orcid:0000-0002-3034-9970 [Term] id: CONSO:CONSO00329 name: N-terminal fragment of ATF6 namespace: protein_fragment def: "N-terminal fragment of the protein ATF6, generated by cleavage through SP1 and SP2 proteases" [pubmed:25784053] relationship: CONSO:author orcid:0000-0002-7128-929X [Term] id: CONSO:CONSO00330 name: misfolded namespace: post_translational_modification def: "Proteins that are not able to achieve the native state, due either to an unwanted mutation in their amino acid sequence or simply because of an error in the folding process, are recognized as misfolded and subsequently targeted to a degradation pathway" [pubmed:16689923] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00331 name: OSW-1 namespace: chemical def: "A novel cholestane glycoside called OSW-1 (3b, 16b, 17a-trihydroxycholest-5-en-22-one 16-O-(2-O-4-methoxybenzoyl-bD-xylopyranosyl) - (1?3) -(2-O-acetyl-a-L-arabinopyranoside)) was recently isolated from Ornithogalum saundersiae (Kubo et al., 1992) and has been found to have a potent growth inhibitory activity on a human tumour cell line" [pubmed:9283720] xref: chebml:CHEMBL375269 xref: inchi:InChI=1S/C47H68O15/c1-24\(2\)8-15-34\(50\)25\(3\)47\(55\)37\(21-33-31-14-11-28-20-29\(49\)16-18-45\(28\,5\)32\(31\)17-19-46\(33\,47\)6\)60-44-41\(59-26\(4\)48\)39\(36\(52\)23-58-44\)62-43-40\(38\(53\)35\(51\)22-57-43\)61-42\(54\)27-9-12-30\(56-7\)13-10-27/h9-13\,24-25\,29\,31-33\,35-41\,43-44\,49\,51-53\,55H\,8\,14-23H2\,1-7H3/t25-\,29+\,31-\,32+\,33+\,35-\,36+\,37+\,38+\,39+\,40-\,41-\,43+\,44+\,45+\,46+\,47-/m1/s1 xref: mesh:C106408 xref: pubchem.compound:9854230 xref: smiles:COc1ccc\(cc1\)C\(=O\)O\[C@@H\]2\[C@@H\]\(O\)\[C@H\]\(O\)CO\[C@H\]2O\[C@H\]3\[C@@H\]\(O\)CO\[C@@H\]\(O\[C@H\]4C\[C@H\]5\[C@@H\]6CC=C7C\[C@@H\]\(O\)CC\[C@\]7\(C\)\[C@H\]6CC\[C@\]5\(C\)\[C@@\]4\(O\)\[C@H\]\(C\)C\(=O\)CCC\(C\)C\)\[C@@H\]3OC\(=O\)C relationship: CONSO:author orcid:0000-0002-6117-4413 synonym: "145075-81-6" EXACT [pubchem.compound:9854230] synonym: "CHEMBL375269" EXACT [pubchem.compound:9854230] synonym: "CS-0020992" EXACT [pubchem.compound:9854230] synonym: "HY-101213" EXACT [pubchem.compound:9854230] synonym: "OSW-1" EXACT [pubchem.compound:9854230] synonym: "SCHEMBL17383554" EXACT [pubchem.compound:9854230] synonym: "ZINC169358856" EXACT [pubchem.compound:9854230] [Term] id: CONSO:CONSO00332 name: EC102 namespace: chemical def: "low–molecular weight Hsp90 N-terminal domain inhibitor" [pubmed:17304350] relationship: CONSO:author orcid:0000-0002-7128-929X [Term] id: CONSO:CONSO00333 name: KU-177 namespace: chemical def: "inhibitor of Aha1" [pubmed:28827321] relationship: CONSO:author orcid:0000-0002-7128-929X [Term] id: CONSO:CONSO00334 name: UBB+1 namespace: protein_variant def: "Ubb+1, a ubiquitin (Ub) mutant protein originating from misreading of the Ub B gene" [pubmed:29175520] relationship: CONSO:author orcid:0000-0002-7128-929X [Term] id: CONSO:CONSO00335 name: Phenylthiazolyl-hydrazide namespace: chemical def: "inhibitor of tau aggregation and toxicity in vitro and in cells" [pubmed:17685560] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00336 name: EEVD motif namespace: motif def: "an acidic motif,EEVD, located at the extreme carboxyl terminus of nearly all Hsp7Os which has an essential role in regulating the biochemical properties of Hsp7O and interactions with HDJ-1" [pubmed:7774586] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00337 name: Hsp27 oligomers namespace: cellular_component def: "Hsp27 exists as an ensemble of oligomers,which range in size from dimers to approximately 32 mers or greater" [pubmed:21882945] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00338 name: SK and F 77434 namespace: chemical def: "a dopamine D1 receptor partial agonist" [pubmed:16820021] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00339 name: [125I]-NCQ 298 namespace: chemical def: "a new selective iodinated salicylamide ligand for the labelling of dopamine D2 receptors with 125I." [pubmed:16820021] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00340 name: AAV-FKBP1B namespace: protein def: "Adeno-associated virus expressing Mouse Fkbp1b." [pubmed:29255009] relationship: CONSO:author orcid:0000-0002-0303-8616 [Term] id: CONSO:CONSO00341 name: Proteostasis namespace: biological_process def: "Regulation of the concentration, folding, interactions, and cellular localization of each of the proteins that comprise the proteome" [pubmed:29127110] xref: mesh:D000074702 relationship: CONSO:author orcid:0000-0002-7128-929X [Term] id: CONSO:CONSO00342 name: N-terminal fragment of APP namespace: domain def: "Fragment of APP (N-APP) that contains heparin-binding and metal-binding domains and that has been found to have biological activity" [pubmed:24916405] relationship: CONSO:author orcid:0000-0002-2046-6145 property_value: bel "p(HGNC:APP, frag(1_?))" xsd:string [Term] id: CONSO:CONSO00343 name: polyQ aggregates namespace: cellular_component def: "Aggregates due to mutations of proteins that lead to polyQ expansions" [pubmed:23483542] relationship: CONSO:author orcid:0000-0002-7128-929X [Term] id: CONSO:CONSO00344 name: Q82 aggregates namespace: cellular_component def: "Aggregates of proteins consisting of polyglutamine stretches with 82 glutamine residues" [pubmed:10811890] relationship: CONSO:author orcid:0000-0002-7128-929X [Term] id: CONSO:CONSO00345 name: non-enzymatic protein modification namespace: biological_process def: "Post-translational protein modifications that were not caused by enzymatic reactions" [pubmed:24563850] relationship: CONSO:author orcid:0000-0002-7128-929X [Term] id: CONSO:CONSO00346 name: bb14 namespace: chemical def: "Tau aggregation inhibitor bb14 (from the rhodanine class of compounds)" [pubmed:26510979] relationship: CONSO:author orcid:0000-0002-7128-929X [Term] id: CONSO:CONSO00347 name: cmp16 namespace: chemical def: "Tau aggregation inhibitor" [pubmed:20392114] relationship: CONSO:author orcid:0000-0002-7128-929X [Term] id: CONSO:CONSO00348 name: misfolding namespace: biological_process def: "Proteins that are not able to achieve the native state, due either to an unwanted mutation in their amino acid sequence or simply because of an error in the folding process, are recognized as misfolded and subsequently targeted to a degradation pathway" [pubmed:16689923] relationship: CONSO:author orcid:0000-0002-7128-929X [Term] id: CONSO:CONSO00349 name: AG18051 namespace: chemical def: "ABAD inhibitor" [pubmed:22174920] xref: inchi:InChI=1S/C19H21N5OS/c25-18\(23-10-6-1-2-7-11-23\)16\(14-8-4-3-5-9-14\)24-13-20-17-15\(19\(24\)26\)12-21-22-17/h3-5\,8-9\,12-13\,16H\,1-2\,6-7\,10-11H2\,\(H\,21\,22\) xref: smiles:C1=N\[N\]C2=C1C\(=S\)N\(C=N2\)C\(C\(=O\)C3CCCCCC3\)C4=CC=CC=C4 relationship: CONSO:author orcid:0000-0002-7128-929X [Term] id: CONSO:CONSO00350 name: RM-532-46 namespace: chemical def: "ABAD inhibitor" [pubmed:22674910] xref: inchi:InChI=1S/C30H44N2O3/c1-35-23-4-2-3-21\(17-23\)19-31-13-15-32\(16-14-31\)20-30\(34\)12-11-24-22\(18-30\)5-6-26-25\(24\)7-8-28-27\(26\)9-10-29\(28\)33/h2-4\,17\,22\,24-28\,34H\,5-16\,18-20H2\,1H3/t22-\,24-\,25+\,26+\,27-\,28-\,30+/m0/s1 xref: smiles:C1\[C@H\]4\[C@H\]\(C\[C@\]\(C1\)\(CN2CCN\(CC2\)CC3=CC\(=CC=C3\)OC\)O\)CC\[C@@H\]5\[C@@H\]4CC\[C@H\]6\[C@H\]5CCC6=O relationship: CONSO:author orcid:0000-0002-7128-929X [Term] id: CONSO:CONSO00351 name: deamidation namespace: post_translational_modification def: "The removal of an amide group from a peptide's side chain" [pubmed:26631930] relationship: CONSO:author orcid:0000-0003-4423-4370 [Term] id: CONSO:CONSO00352 name: Mini-Mental Status Exam namespace: clinical_measurement def: "A standardized and structured interview originally developed by Marshal Folstein, Susan Folstein and Paul McHugh (Journal of Psychiatric Research, 1975), which is used to evaluate an individual's cognitive function." [ncit:C74982] xref: ncit:C74982 xref: umls:C0451306 relationship: CONSO:author orcid:0000-0003-4423-4370 synonym: "Folstein Mini-Mental Status Exam" EXACT [ncit:C74982] synonym: "MMS1" EXACT [ncit:C74982] synonym: "MMSE" EXACT [ncit:C74982] synonym: "Mini-Mental State Examination Questionnaire" EXACT [ncit:C74982] synonym: "Mini-Mental_Status_Exam" EXACT [ncit:C74982] [Term] id: CONSO:CONSO00353 name: GLAP namespace: chemical def: "glyceraldehyde-derived pyridinium-type advanced glycation end product (AGE), formed by glyceraldehyde-related glycation" [pubmed:25582325, pubmed:17284838] xref: inchi:InChI=1S/C12H18N2O4/c13-4-2-1-3-11\(12\(17\)18\)14-6-9\(8-15\)5-10\(16\)7-14/h5-7\,11\,15H\,1-4\,8\,13H2\,\(H-\,16\,17\,18\)/t11-/m0/s1 xref: smiles:NCCCC\[C@@H\]\(C\(=O\)O\)\[N+\]1=CC\(=CC\(=C1\)\[O-\]\)CO relationship: CONSO:author orcid:0000-0002-7128-929X synonym: "1-(5-acetylamino-5-carboxypentyl)-3-hydroxy-5-hydroxymethyl-pyridinium" EXACT [pubmed:12784645] synonym: "Glyceraldehyde derived Pyridinium compound" EXACT [pubmed:12784645] synonym: "Glyceraldehyde-derived Pyridinium compound" EXACT [pubmed:12784645] [Term] id: CONSO:CONSO00354 name: Tau 6D namespace: isoform def: "In addition to the 3′ splice site at the end of exon 6, there are two alternate 3′ splice sites within exon 6 itself, termed “6P” and “6D” according to location (Fig. 1). Use of either of these splice sites results in a frame shift that introduces a unique amino acid sequence, PCCVPRATFLS (6P) or FWSKGDETQGG (6D), followed by a stop codon. As a result, tau 6P and 6D isoforms are truncated, lacking part of the proline-rich region, the MTBR region, and C-terminus" [pubmed:21734277, pubmed:19919107] relationship: CONSO:has_reference_protein uniprot:P10636 relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00355 name: Tau 6P namespace: isoform def: "In addition to the 3′ splice site at the end of exon 6, there are two alternate 3′ splice sites within exon 6 itself, termed “6P” and “6D” according to location (Fig. 1). Use of either of these splice sites results in a frame shift that introduces a unique amino acid sequence, PCCVPRATFLS (6P) or FWSKGDETQGG (6D), followed by a stop codon. As a result, tau 6P and 6D isoforms are truncated, lacking part of the proline-rich region, the MTBR region, and C-terminus" [pubmed:21734277, pubmed:19919107] relationship: CONSO:has_reference_protein uniprot:P10636 relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00356 name: Peripheral Tissue namespace: anatomy def: "Parts of the body that act as a response to a change in the environment, the body's functions, molecule levels, etc." [pubmed:27758088] relationship: CONSO:author orcid:0000-0002-7128-929X [Term] id: CONSO:CONSO00357 name: tau polyclonal antibody namespace: antibody def: "Antibodies, that are able to bind different epitopes of the tau protein" [pubmed:29590627] relationship: CONSO:author orcid:0000-0002-7128-929X [Term] id: CONSO:CONSO00358 name: TDP-43 oligomers namespace: cellular_component def: "oligomers form during the early steps of TDP-43 misfolding" [pubmed:30824544] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00359 name: TDP-43 aggregates namespace: cellular_component def: "TDP-43 aggregates are formed through a biphasic process that initiates with oligomerization followed by aggregation into high molecular weight polymers" [pubmed:30824544] relationship: CONSO:author orcid:0000-0002-6117-4413 [Term] id: CONSO:CONSO00360 name: Clonal Expansion namespace: pathology def: "Multiplication or reproduction by cell division of a population of identical cells descended from a single progenitor. In immunology, may refer to the clonal proliferation of cells responsive to a specific antigen as part of an immune response." [pubmed:27794524] xref: ncit:C20613 relationship: CONSO:author orcid:0000-0002-7683-0452 [Term] id: CONSO:CONSO00361 name: CDR - Sum of Boxes namespace: clinical_measurement def: "Clinical Dementia Rating (CDR) Sum of Boxes" [pubmed:25468261, pubmed:23626081, pubmed:27084223] xref: ncit:C113880 xref: umls:C3827230 relationship: CONSO:author orcid:0000-0003-4423-4370 [Term] id: CONSO:CONSO00362 name: Tau antibody, MC1 namespace: antibody def: "mouse monoclonal antibody specific to tau epitopes within 312 to 322 amino acid" [pubmed:28148553, pubmed:23638068, pubmed:21841002] xref: antibodyregistry:AB_2314773 relationship: CONSO:author orcid:0000-0002-7683-0452 [Term] id: CONSO:CONSO00363 name: DC8E8 namespace: antibody def: "recombinant mouse antibody specifc to MAPT" [pubmed:4255369, pubmed:25478017] xref: pdb:4OZ4 xref: url:https\://www.creativebiolabs.net/Anti-Tau-Antibody-24886.htm relationship: CONSO:has_antibody_target MGI:MGI:97180 relationship: CONSO:author orcid:0000-0002-7683-0452 [Term] id: CONSO:CONSO00364 name: DC11 namespace: antibody def: "monoclonal mouse antibody specifc to MAPT" [pubmed:4255369, pubmed:12544837] relationship: CONSO:author orcid:0000-0002-7683-0452 [Term] id: CONSO:CONSO00365 name: MN423 namespace: antibody def: "recombinant mouse antibody binding to PHF core of MAPT" [pubmed:4255369, pubmed:25478017] xref: pdb:2V17 xref: url:https\://www.creativebiolabs.net/Anti-PHF-core-Antibody-24396.htm relationship: CONSO:has_antibody_target MGI:MGI:97180 relationship: CONSO:author orcid:0000-0002-7683-0452 [Term] id: CONSO:CONSO00366 name: AADvac1 namespace: antibody def: "active vaccine eliciting an immune response against pathologically modified forms of tau protein" [pubmed:25478017] xref: url:https\://www.alzforum.org/therapeutics/aadvac1 relationship: CONSO:author orcid:0000-0002-7683-0452 [Term] id: CONSO:CONSO00367 name: RGFP136 namespace: chemical def: "HDAC3 inhibitor" [pubmed:23356410, pubmed:21228185] xref: inchi:InChI=1S/C20H24FN3O2/c1-14-6-8-15\(9-7-14\)20\(26\)23-12-4-2-3-5-19\(25\)24-18-11-10-16\(21\)13-17\(18\)22/h6-11\,13H\,2-5\,12\,22H2\,1H3\,\(H\,23\,26\)\(H\,24\,25\) xref: mesh:C556032 xref: smiles:NC1=C\(C=CC\(=C1\)F\)NC\(CCCCCNC\(C1=CC=C\(C=C1\)C\)=O\)=O relationship: ro:0000087 CONSO:CONSO00368 relationship: CONSO:author orcid:0000-0002-7683-0452 synonym: "N-(6-(2-amino-4-fluorophenylamino)-6-oxohexyl)-4-methylbenzamide" EXACT [mesh:C556032] synonym: "RGFP 136" EXACT [mesh:C556032] [Term] id: CONSO:CONSO00368 name: HDAC3 inhibitor namespace: chemical_role def: "Compounds that inhibit Histone Deactelylase 3(HDAC-3)" [pubmed:23356410, pubmed:21228185] relationship: CONSO:author orcid:0000-0002-7683-0452 [Term] id: CONSO:CONSO00369 name: chemofog namespace: pathology def: "Long-term chemotherapy-induced cognitive decline in cancer survivors" [pubmed:30112764, pubmed:30382534, pubmed:28916767] relationship: CONSO:author orcid:0000-0003-4423-4370 synonym: "CICI" EXACT [pubmed:20832978] synonym: "Chemotherapy-induced cognitive impairment" EXACT [pubmed:20832978] synonym: "chemo brain" EXACT [pubmed:20832978] synonym: "chemobrain" EXACT [pubmed:20832978] [Term] id: CONSO:CONSO00370 name: Chemotherapy-induced peripheral neuropathy namespace: pathology def: "neuropathy caused by chemotherapy" [pubmed:31363906, pubmed:30244980, pubmed:25256375, pubmed:31783290, pubmed:24830939] relationship: CONSO:author orcid:0000-0003-4423-4370 synonym: "CIPN" EXACT [pubmed:25256375] synonym: "chemotherapy induced peripheral neuropathy" EXACT [pubmed:25256375]