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anatomy
antibody
aptamer
biological process
cellular component
chemical
chemical (proprietary)
chemical class
chemical mixture
chemical role
clinical measurement
domain
enzyme class
epitope
exposure
genetic variant
isoform
molecular function
motif
pathology
pathway
peptide
post-translational modification
protein
protein complex
protein family
protein fragment
protein isoform family
protein variant
The motif in the MAPT protein where microtubule binding repeats
microtubule-binding region
MTBR
pubmed:18500754
pubmed:2516729
interpro:IPR001084
orcid:0000-0003-4423-4370
position 569_591 of canonical isoform of MAPT protein
tubulin-binding repeat 1
MTBR R1
R1
pubmed:18500754
orcid:0000-0001-9661-5277
p(HGNC:MAPT, frag(569_591))
position 592_621 of canonical isoform of MAPT protein
tubulin-binding repeat 2
MTBR R2
R2
pubmed:18500754
orcid:0000-0001-9661-5277
p(HGNC:MAPT, frag(592_621))
position 623_653 of canonical isoform of MAPT protein
tubulin-binding repeat 3
MTBR R3
R3
pubmed:18500754
orcid:0000-0001-9661-5277
p(HGNC:MAPT, frag(623_653))
position 654_685 of canonical isoform of MAPT protein
tubulin-binding repeat 4
MTBR R4
R4
pubmed:18500754
orcid:0000-0001-9661-5277
p(HGNC:MAPT, frag(654_685))
Tau (MAPT) in its aggregated form (as Paired Helical Filaments (PHFs) or Straight Filaments (SF)) contains 5–9 moles of phosphate/ mole of the protein, defining it as hyper phosphorylated
Tau aggregates
pmc:PMC2633703
orcid:0000-0003-4423-4370
An excessive phosphorylation (see GO:0006468)
hyperphosphorylation
pubmed:22710920
orcid:0000-0003-4423-4370
temperature-sensitive allele of GAL80 (tub-GAL80TS)
GAL80TS
pmc:PMC3073608
orcid:0000-0002-6117-4413
CAST is known to prevent oligomerization of Tau (Rao et al., 2014) and α-synuclein (Diepenbroek et al. 2014) and inhibit reactive gliosis (Rao et al., 2008)
Tau oligomers
pmc:PMC4828294
orcid:0000-0002-6117-4413
a typo appearing in pubmed:23950935 for the specific PI3-kinase inhibitor that is actually named LY294002
LY293002
154447-36-6
15447-36-6
1yi3
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
2-(4-morpholino)-8-phenyl-4H-1-benzopyran-4-one
2-(morpholin-4-yl)-8-phenyl-4H-chromen-4-one
2-(morpholin-4-yl)-8-phenylchromen-4-one
2-MORPHOLIN-4-YL-7-PHENYL-4H-CHROMEN-4-ONE
2-Morpholin-4-yl-8-phenyl-chromen-4-one
2-Morpholino-8-phenyl-4-oxo-4H-1-benzopyran
2-Morpholino-8-phenylchromone
2-morpholin-4-yl-8-phenyl-4H-chromen-4-one
2-morpholin-4-yl-8-phenylchromen-4-one
2-morpholino-8-phenyl-4H-chromen-4-one
2-morpholino-8-phenyl-chromen-4-one
31M2U1DVID
4CA-0787
4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl
4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-
4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl- (9CI)
4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-(9CI)
4H-1-Benzopyran-4-one,2-(4-morpholinyl)-8-phenyl-
4azt
8-Phenyl-2-(morpholin-4-yl)-chromen-4-one
AB0033714
AC-30295
AC1L1H4N
AC1Q6CLU
AK162301
AKOS017344742
AN-1305
API0015880
AS-16252
BC660045
BCBcMAP01_000117
BCP00195
BCP9000880
BCPP000177
BDBM12915
BIL2940
BMK1-D5
BRD-K27305650-001-05-9
BSPBio_001223
Bio1_000332
Bio1_000821
Bio1_001310
Bio2_000442
Bio2_000922
BiomolKI2_000037
BiomolKI_000029
C15195
CBiol_002046
CCG-100633
CHEBI:65329
CHEMBL98350
CS-0150
CTK0H1979
CZQHHVNHHHRRDU-UHFFFAOYSA-N
D09SFV
D0X7NA
DB02656
DTXSID6042650
EC-000.2341
EX-A073
FT-0660382
GTPL6004
H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl- (9CI)
H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-(9CI)
HMS1362M05
HMS1792M05
HMS1990M05
HMS3229G17
HMS3403M05
HMS3649E04
HMS3654M21
HSCI1_000206
HY-10108
IDI1_002197
IN1266
IN1268
InSolution™ LY 294002
J-510126
K00235
KB-19284
KB-231805
KBio2_000563
KBio2_003131
KBio2_005699
KBio3_001005
KBio3_001006
KBioGR_000563
KBioSS_000563
KS-00000XP3
Kinome_3543
LS-39828
LY 294002
LY 294002, LY-294002, 154447-36-6
LY 294002; 2-(4-Morpholino)-8-phenyl-4H-1-benzopyran-4-one
LY-294,002
LY-294,002 hydrochloride, solid, >=98% (HPLC)
LY-294002
LY-924002
LY2
LY294002
Lopac-L-9908
Lopac0_000710
Lys 294002
M2410
MLS006010131
MolPort-003-983-779
NCGC00015622-01
NCGC00015622-02
NCGC00015622-03
NCGC00015622-04
NCGC00015622-05
NCGC00015622-06
NCGC00015622-07
NCGC00025020-01
NCGC00025020-02
NCGC00025020-03
NCGC00025020-04
NCGC00179253-01
NCI60_034712
NSC 697286
NSC-697286
NSC697286
PubChem16766
QC-7260
RS0074
RT-013609
S-7706
SB10965
SC-85850
SCHEMBL94377
SF 1101
SF-1101
SMR002530642
SR-01000076245-7
ST24040926
SW217688-2
SYN1108
Tocris-1130
UNII-31M2U1DVID
X7411
ZINC6014
ZX-AFC000490
cc-58
s1105
pubmed:23950935
cas:154447-36-6
chebi:CHEBI:65329
drugbank:DB02656
inchi:InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
pubchem.compound:3973
smiles:C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4
orcid:0000-0002-3034-9970
Low-power laser irradiation (LPLI) is a non-damage physical therapy
LPLI
Low-power laser irradiation
pubmed:20333643
orcid:0000-0002-3034-9970
Chronic cerebral hypoperfusion (CCH) is one of the causes of vascular dementia (VaD) and is also an etiological factor for Alzheimer's disease (AD)
Chronic cerebral hypoperfusion
CCH
pubmed:24575038
orcid:0000-0002-3034-9970
ethanol extracted from Mori Fructus, a well-known traditional herbal medicine, food, and dietary supplement
Mori Fructus ethanol extract
ME
pubmed:26068423
orcid:0000-0002-3034-9970
filamentous-actin-containing membranous structures that bridge and connect cells
tunneling nanotubes
TNT
membrane nanotube
pubmed:27809932
orcid:0000-0002-3034-9970
production of amyloid
amyloidogenesis
pubmed:24653673
orcid:0000-0002-3034-9970
alpha-synuclein (SNCA) aggregate in fibrillar or oligomeric forms, usually found in Lewy bodies
alpha-synuclein aggregates
pubmed:23254192
orcid:0000-0003-4423-4370
huntingtin (HTT) protein fragments aggregations
huntingtin aggregates
pubmed:12747895
orcid:0000-0003-4423-4370
aggregation of amyloid-beta fragments of the APP protein
amyloid-beta aggregates
pubmed:23484434
orcid:0000-0003-4423-4370
A tau aggregation inhibitor
SEN-1269
3-((5-(3-(Dimethylamino)phenoxy)pyrimidin-2-yl)amino)phenol
3-(5-(3-(dimethylamino)phenoxy)pyrimidin-2-ylamino)phenol
3-({5-[3-(dimethylamino)phenoxy]pyrimidin-2-yl}amino)phenol
3-[[5-[3-(dimethylamino)phenoxy]-2-pyrimidinyl]amino]phenol
4350AF
956128-01-1
A11161
AKOS015850742
CHEMBL2386874
CTK5H7888
DB-080315
DTXSID40676566
FT-0682533
I06-2365
MFPAAKZZUIRMKR-UHFFFAOYSA-N
MolPort-009-685-119
NCGC00387448-01
SCHEMBL3602388
SEN 1269
TC-064564
ZINC49582255
pubmed:23484434
chembl:CHEMBL2386874
inchi:InChI=1S/C18H18N4O2/c1-22(2)14-6-4-8-16(10-14)24-17-11-19-18(20-12-17)21-13-5-3-7-15(23)9-13/h3-12,23H,1-2H3,(H,19,20,21)
pubchem.compound:46835756
smiles:CN(C)C1=CC(=CC=C1)OC2=CN=C(N=C2)NC3=CC(=CC=C3)O
orcid:0000-0003-4423-4370
A tau aggregation inhibitor
MLS000034832
123542-47-2
3-Phenyl-4-oxo-5-amino-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylic acid ethyl ester
5-Amino-4-oxo-3-phenyl-3,4-dihydro-thieno[3,4-d]pyridazine-1-carboxylic acid eth
5-Amino-4-oxo-3-phenyl-3,4-dihydro-thieno[3,4-d]pyridazine-1-carboxylic acid ethyl ester
AC1LDGR2
AC1Q34EJ
AKOS000601368
BAS 06046551
BDBM50253793
CCG-115473
CHEMBL461431
F2135-0238
HLVGVGCIJRBRQW-UHFFFAOYSA-N
HMS1616C21
HMS2339G13
L-4233
MCULE-6208802152
MLS000034832
MLS002539346
MolPort-001-835-700
NCGC00031883-02
SCHEMBL7885074
SMR000013604
ZINC563211
ethyl 5-amino-4-oxo-3-phenyl-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate
ethyl 5-amino-4-oxo-3-phenyl-3H,4H-thieno[3,4-d]pyridazine-1-carboxylate
ethyl 5-amino-4-oxo-3-phenylthieno[3,4-d]pyridazine-1-carboxylate
pubmed:23484434
chembl:CHEMBL461431
inchi:InChI=1S/C15H13N3O3S/c1-2-21-15(20)12-10-8-22-13(16)11(10)14(19)18(17-12)9-6-4-3-5-7-9/h3-8H,2,16H2,1H3
pubchem.compound:647821
smiles:CCOC(=O)C1=NN(C(=O)C2=C(SC=C21)N)C3=CC=CC=C3
orcid:0000-0003-4423-4370
A tau aggregation inhibitor
caprospinol
((20S,22R,25R)-Spirosta-5-ene-3beta-ol)hexanoate
(22R,25R)-20alpha-Spirost-5-en-3beta-yl hexanoate
(3beta,8xi,9xi,14xi,16xi,17xi,20R,22xi,25R)-Spirost-5-en-3-yl hexanoa
4952-56-1
9BU4T267E4
AKOS015955746
CAPROSPINOL
DB05263
Diosgenin caproate
Diosgenin, hexanoate
J2.343.184J
MCULE-6852340934
MolPort-002-507-344
SP-223
SP-233
Spirost-5-en-3-ol, 3-hexanoate, (3beta,25R)-
UNII-9BU4T267E4
ZINC97971833
pubmed:23484434
drugbank:DB05263
inchi:InChI=1S/C33H52O4/c1-6-7-8-9-29(34)36-24-13-15-31(4)23(18-24)10-11-25-26(31)14-16-32(5)27(25)19-28-30(32)22(3)33(37-28)17-12-21(2)20-35-33/h10,21-22,24-28,30H,6-9,11-20H2,1-5H3/t21-,22+,24+,25-,26+,27+,28+,30+,31+,32+,33-/m1/s1
pubchem.compound:16394575
smiles:CCCCCC(=O)O[C@H]1CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](C[C@@H]5O[C@]6(CC[C@@H](C)CO6)[C@@H](C)[C@H]45)[C@@H]3CC=C2C1
orcid:0000-0003-4423-4370
Small aggregates of amyloid-beta
amyloid-beta oligomers
pubmed:29196815
pubmed:24918635
orcid:0000-0003-4423-4370
Amyloid-beta oligomers composed specifically of amyloid-beta 42
amyloid-beta 42 oligomers
pubmed:24918635
orcid:0000-0003-4423-4370
C-terminally truncated carboxyl-terminal fragments (CTFs) of APP
APP C-terminally truncated carboxyl-terminal fragments
pubmed:15491160
orcid:0000-0002-0303-8616
A2B5 antigen is a cell surface ganglioside epitope expressed on developing thymic epithelial cells, oligodendrocyte progenitors, and neuroendocrine cells.
A2B5 antigen
pubmed:1497614
orcid:0000-0002-0303-8616
Sphingomyelin phosphodiesterase (EC 3.1.4.12, also known as neutral sphingomyelinase, sphingomyelinase, or SMase) is a hydrolase enzyme that is involved in sphingolipid metabolism reactions.
neutral sphingomyelinase
pubmed:19519303
ec-code:3.1.4.12
orcid:0000-0002-0303-8616
Neurodegeneration is the progressive loss of structure or function of neurons, including death of neurons. Many neurodegenerative diseases – including amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease, and Huntington's disease – occur as a result of neurodegenerative processes.
Neurodegeneration
pubmed:12387894
pubmed:20202123
hp:HP:0002180
orcid:0000-0002-0303-8616
soluble oligomeric forms of the amyloid beta peptide known as amyloid-derived diffusible ligands (ADDLs) are the toxic species responsible for neurodegeneration associated with Alzheimer's disease.
amyloid-beta derived diffusible ligands
ADDL
pubmed:19188609
orcid:0000-0002-0303-8616
increased secretion of the pancreatic hormone amylin
Hyperamylinemia
pubmed:23794448
orcid:0000-0002-0303-8616
APOE e4 is a variant of APOE, it's APOE-ε4 (arg112, arg158).
APOE e4
pubmed:22701550
orcid:0000-0002-0303-8616
N-AcGIP is a rat hormone that is an agonist of GIP
N-AcGIP
pubmed:18234983
orcid:0000-0002-0303-8616
Pro3-GIP is a rat hormone that is an agonist of GIP
Pro3-GIP
AKOS034831571
[Pro3]-GIP (Rat)
pubmed:18234983
inchi:InChI=1S/C226H343N61O64S/c1-21-115(12)181(285-216(341)165(109-289)279-201(326)151(92-126-63-67-131(293)68-64-126)266-210(335)163(102-179(309)310)276-215(340)164(108-288)280-221(346)183(117(14)23-3)284-214(339)153(91-124-48-28-25-29-49-124)277-222(347)184(121(18)290)281-175(302)107-247-217(342)166-60-45-84-287(166)224(349)120(17)251-188(313)134(232)89-125-61-65-130(292)66-62-125)219(344)250-119(16)187(312)254-146(77-85-352-20)197(322)274-160(99-176(303)304)208(333)258-141(58-38-43-82-231)198(323)283-182(116(13)22-2)220(345)261-142(59-44-83-243-226(240)241)191(316)259-144(70-74-168(234)295)195(320)260-145(71-75-169(235)296)196(321)273-161(100-177(305)306)209(334)267-152(90-123-46-26-24-27-47-123)213(338)282-180(114(10)11)218(343)278-159(98-173(239)300)207(332)268-155(94-128-104-245-136-53-33-31-51-133(128)136)203(328)264-149(87-112(6)7)200(325)263-148(86-111(4)5)199(324)249-118(15)186(311)253-143(69-73-167(233)294)194(319)255-137(54-34-39-78-227)189(314)246-106-174(301)252-138(55-35-40-79-228)190(315)256-139(56-36-41-80-229)193(318)271-157(96-171(237)298)206(331)275-162(101-178(307)308)211(336)269-154(93-127-103-244-135-52-32-30-50-132(127)135)202(327)257-140(57-37-42-81-230)192(317)270-156(95-129-105-242-110-248-129)204(329)272-158(97-172(238)299)205(330)265-150(88-113(8)9)212(337)286-185(122(19)291)223(348)262-147(225(350)351)72-76-170(236)297/h24-33,46-53,61-68,103-105,110-122,134,137-166,180-185,244-245,288-293H,21-23,34-45,54-60,69-102,106-109,227-232H2,1-20H3,(H2,233,294)(H2,234,295)(H2,235,296)(H2,236,297)(H2,237,298)(H2,238,299)(H2,239,300)(H,242,248)(H,246,314)(H,247,342)(H,249,324)(H,250,344)(H,251,313)(H,252,301)(H,253,311)(H,254,312)(H,255,319)(H,256,315)(H,257,327)(H,258,333)(H,259,316)(H,260,320)(H,261,345)(H,262,348)(H,263,325)(H,264,328)(H,265,330)(H,266,335)(H,267,334)(H,268,332)(H,269,336)(H,270,317)(H,271,318)(H,272,329)(H,273,321)(H,274,322)(H,275,331)(H,276,340)(H,277,347)(H,278,343)(H,279,326)(H,280,346)(H,281,302)(H,282,338)(H,283,323)(H,284,339)(H,285,341)(H,286,337)(H,303,304)(H,305,306)(H,307,308)(H,309,310)(H,350,351)(H4,240,241,243)
pubchem.compound:131954578
smiles:CCC(C)C(C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)C)C(=O)NC(CC(=O)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(CCC(=O)N)C(=O)NC(CCCCN)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)NC(CCCCN)C(=O)NC(CC6=CNC=N6)C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)O)C(=O)NC(CCC(=O)N)C(=O)O)NC(=O)C(CCCCN)NC(=O)C(CC(=O)O)NC(=O)C(CCSC)NC(=O)C(C)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(CC7=CC=C(C=C7)O)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)CC)NC(=O)C(CC8=CC=CC=C8)NC(=O)C(C(C)O)NC(=O)CNC(=O)C9CCCN9C(=O)C(C)NC(=O)C(CC1=CC=C(C=C1)O)N
orcid:0000-0002-0303-8616
PI3K-Akt signaling pathway is an intracellular signaling pathway important in regulating the cell cycle.It is described in KEGG.
PI3K-Akt signaling pathway
pubmed:22013558
kegg.pathway:hsa04151
orcid:0000-0002-0303-8616
Argyrophilic grain disease (AGD) is an under-recognized, distinct, highly frequent sporadic tauopathy, with a prevalence reaching 31.3% in centenarians.
Argyrophilic Grain Disease
AGD
pubmed:15658002
orcid:0000-0002-0303-8616
Granulovacuolar degeneration (GVD) is one of the pathological hallmarks of Alzheimer's disease (AD), and it is defined as electron-dense granules within double membrane-bound cytoplasmic vacuoles.
granulovacuolar degeneration
GVD
pubmed:17455299
hp:HP:0002528
orcid:0000-0002-0303-8616
mitochondria function disorder
mitochondrial dysfunction
pubmed:19885299
orcid:0000-0002-0303-8616
Insoluble fibrous protein aggregates exhibiting beta sheet structure.
amyloid-beta fibrils
pubmed:19158505
orcid:0000-0003-4423-4370
a peptide derived from mouse laminin alpha 1 protein (seq:RKRLQVQLSIRT, chain:2719–2730)
AG73
pubmed:20615691
orcid:0000-0002-3034-9970
p(MGI:Lama1, frag(2719_2730))
Notch intracellular domain is the intracellular region of notch receptor.
Notch intracellular domain
pubmed:20883690
orcid:0000-0002-0303-8616
YENTY is the endocytosis motif of Amyloid precursor protein.
YENPTY endocytosis motif (APP)
YENPTY
pubmed:18650430
orcid:0000-0002-0303-8616
Soluble amyloid precursor protein
sAPP-beta
soluble amyloid precursor protein
pubmed:21606494
orcid:0000-0002-0303-8616
A growth factor is a naturally occurring substance capable of stimulating cellular growth, proliferation, healing, and cellular differentiation. Usually it is a protein or a steroid hormone. Growth factors are important for regulating a variety of cellular processes.
growth factor
pubmed:14678766
ncit:C20424
umls:C0018284
orcid:0000-0002-0303-8616
Tau isoforms containing 3 tubulin binding repeats
3R tau
pubmed:23407988
orcid:0000-0001-9661-5277
Tau isoforms containing 4 tubulin binding repeats
4R tau
pubmed:23407988
orcid:0000-0001-9661-5277
A hexapeptide motif located in the R2, that promotes the formation of PHF
VQIINK motif
PHF6*
pubmed:17493042
orcid:0000-0001-9661-5277
A hexapeptide motif located in the R3, that promotes the formation of PHF
VQIVYK motif
PHF6
pubmed:17493042
orcid:0000-0001-9661-5277
Extracellular NFT remains after neuron death, considered to be the last stage of NFT-related pathological activity.
ghost tangles
pubmed:8431763
pubmed:23407988
orcid:0000-0001-9661-5277
Pretangles are cytoplasmic tau immunoreactivity in neurons without apparent formation of fibrillary structures. In Alzheimer disease, such tau deposition is considered to represent a premature state prior to fibril formation (AD-pretangles), later to form neurofibrillary tangles and finally ghost tangles.
pretangles
pubmed:23407988
pubmed:24612177
orcid:0000-0001-9661-5277
Corresponding roughly to the N-terminal part of the tau molecule, consisting mainly of acidic residues and containing two distinct alternatively spliced N-terminal inserts.
projection domain
MAP2/Tau projection
pubmed:17493042
pubmed:28386764
interpro:IPR013588
orcid:0000-0001-9661-5277
A constitutively active splicing isoform of RAC1 (Ras-related C3 botulinum toxin substrate 1), first identified in breast and colon cancer.
RAC1b
pubmed:22142809
uniprot.isoform:P63000-2
orcid:0000-0001-9661-5277
A heterotetrameric adapter protein complex involved in cargo-internalization during clathrin-mediated endocytosis. Composed of alpha and beta subunits (large adaptins), mu and sigma subunits (minor adaptins).
AP-2 complex
pubmed:27260836
go:GO:0030122
orcid:0000-0001-9661-5277
Longest tau isoform in human brain, most commonly used as the conventional tau.
Tau isoform F (441 aa)
2N4R
htau40
microtubule-associated protein tau isoform 2
pubmed:17493042
ncbiprotein:NP_005901
uniprot.isoform:P10636-8
orcid:0000-0001-9661-5277
Human fetal tau isoform.
Tau isoform Fetal-tau (352 aa)
0N3R
htau23
microtubule-associated protein tau isoform 4
pubmed:17493042
ncbiprotein:NP_058525
uniprot.isoform:P10636-2
orcid:0000-0001-9661-5277
Human brain tau isoform, derived from alternative splicing.
Tau isoform B (381 aa)
1N3R
htau37
microtubule-associated protein tau isoform 7
pubmed:17493042
ncbiprotein:NP_001190180
uniprot.isoform:P10636-4
orcid:0000-0001-9661-5277
Human brain tau isoform, derived from alternative splicing.
Tau isoform D (383 aa)
0N4R
htau24
microtubule-associated protein tau isoform 3
pubmed:17493042
ncbiprotein:NP_058518
uniprot.isoform:P10636-6
orcid:0000-0001-9661-5277
Human brain tau isoform, derived from alternative splicing.
Tau isoform C (410 aa)
2N3R
htau39
microtubule-associated protein tau isoform 8
pubmed:17493042
ncbiprotein:NP_001190181
uniprot.isoform:P10636-5
orcid:0000-0001-9661-5277
Human brain tau isoform, derived from alternative splicing.
Tau isoform E (412 aa)
1N4R
htau34
microtubule-associated protein tau isoform 5
pubmed:17493042
ncbiprotein:NP_001116539
uniprot.isoform:P10636-7
orcid:0000-0001-9661-5277
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Serpin-enzyme complex receptor
SEC-R
pubmed:2160076
pubmed:15160835
orcid:0000-0002-0303-8616
inflammatory response in the brain and nervous tissue.
neuroinflammation
pubmed:26306439
go:GO:0150076
orcid:0000-0002-3034-9970
happens when a biological, physical or chemical agent cause any adverse effect on the structure and function of the nerves system.
neurotoxicity
pubmed:18440072
orcid:0000-0002-3034-9970
when the neurite is unable it outgrow and extend
neurite retraction
pubmed:19022228
orcid:0000-0002-3034-9970
the APP gene is located on chromosome 21 in humans with three major isoforms arising from alternative splicing [3]. These are APP695, APP751 and APP770 (containing 695, 751, and 770 amino acids, respectively)
APP695
pubmed:21214928
uniprot.isoform:P05067-4
orcid:0000-0002-6117-4413
the APP gene is located on chromosome 21 in humans with three major isoforms arising from alternative splicing [3]. These are APP695, APP751 and APP770 (containing 695, 751, and 770 amino acids, respectively)
APP751
pubmed:21214928
uniprot.isoform:P05067-8
orcid:0000-0002-6117-4413
the APP gene is located on chromosome 21 in humans with three major isoforms arising from alternative splicing [3]. These are APP695, APP751 and APP770 (containing 695, 751, and 770 amino acids, respectively)
APP770
pubmed:21214928
uniprot.isoform:P05067-1
orcid:0000-0002-6117-4413
gamma-secretase is a high molecular weight complex minimally composed of four components: presenilins (PS), nicastrin, anterior pharynx defective 1 (APH-1), and presenilin enhancer 2 (PEN-2)
gamma-secretase
pubmed:25565961
fplx:Gamma_secretase
orcid:0000-0002-6117-4413
soluble amyloid precursor protein-alpha
sAPP-alpha
pubmed:22491325
orcid:0000-0002-6117-4413
Excitotoxicity is defined as cell death resulting from the toxic actions of excitatory amino acids
Excitotoxicity
pubmed:19343058
orcid:0000-0002-6117-4413
a fragment containing the last 31 amino acids of APP (called C31)
C31
pubmed:21214928
orcid:0000-0002-6117-4413
Additional gamma-cleavage further generates the fragment (called Jcasp) containing the region between gamma- and caspase-cleavage sites
Jcasp
pubmed:21214928
orcid:0000-0002-6117-4413
APP intracellular domain
AICD
pubmed:21214928
orcid:0000-0002-6117-4413
APP alphaCTF and betaCTF are further cleaved by gamma-secretase to generate p83 and Abeta, respectively
p83
pubmed:21214928
orcid:0000-0002-6117-4413
Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein (see:GO:0016485)
APP processing
pubmed:21214928
orcid:0000-0002-6117-4413
soluble Aβ oligomers
AβOs
pubmed:24685176
orcid:0000-0002-7128-929X
The formation of AβOs starts from alterations in the conformation of monomeric Aβ, resulting in low molecular weight (LMW) dimers and trimers, followed by aggregation to soluble spherical oligomers consisted of 12–24 monomers.
LMW amyloid oligomers
pubmed:18723507
orcid:0000-0002-7128-929X
Amyloid-beta oligomers composed specifically of amyloid-beta 40
amyloid-beta 40 oligomers
pubmed:21209907
orcid:0000-0002-7128-929X
The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition (see:GO:0000380)
alternative splicing of APP gene
pubmed:22122372
orcid:0000-0002-6117-4413
The ectodomains of APP and APLPs have two conserved regions called E1 and E2 (Fig. 1A), both of which have been proposed to contribute to dimerization
E1 domain
pubmed:21574595
orcid:0000-0002-6117-4413
The ectodomains of APP and APLPs have two conserved regions called E1 and E2 (Fig. 1A), both of which have been proposed to contribute to dimerization
E2 domain
pubmed:21574595
orcid:0000-0002-6117-4413
Cleavage by α-secretase yields the nonamyloidogenic soluble 3-kDa peptide (p3) that does not form amyloid fibrils, whereas cleavage by β-secretase yields the amyloidogenic form Aβ1–40 or the longer, more fibrillogenic Aβ1–42
P3 peptide
pubmed:22137428
orcid:0000-0002-6117-4413
a membrane associated C-terminal fragment consisting of 99 amino acids (C99)
C99
pubmed:22122372
orcid:0000-0002-6117-4413
amnestic Mild Cognitive Impairement is a cognitive dysfunction that is associated with memory deficits
aMCI
pubmed:18986241
orcid:0000-0002-3034-9970
multi-domain Mild Cognitive Impairement is a cognitive dysfunction that is associated with more than one cognitive domain
mdMCI
pubmed:18986241
orcid:0000-0002-3034-9970
Human brain tau isoform, derived from alternative splicing.
Tau isoform A (316 aa)
pubmed:18986241
uniprot.isoform:P10636-3
orcid:0000-0002-3034-9970
Tau epitope cleaved at aspartic acid(421).
Tau C3
pubmed:18986241
orcid:0000-0002-3034-9970
Tau epitope truncated at glutamic acid(391).
Tau MN423
pubmed:18986241
orcid:0000-0002-3034-9970
When the oligomer lengthens, it adapts a beta-sheet structure and transforms into a detergent-insoluble aggregate with granular appearance under Atomic Force Microscopy (AFM)
granular tau oligomers
pubmed:28420982
orcid:0000-0002-6117-4413
As these granular tau oligomers fuse together, they form tau fibrils, which ultimately form NFTs
Tau fibrils
pubmed:28420982
orcid:0000-0002-6117-4413
Dense-core plaques are fibrillar deposits of Abeta, showing all the classical properties of amyloid including beta-sheet secondary structure, while diffuse plaques are amorphous deposits
dense core plaques
pubmed:17680701
orcid:0000-0002-6117-4413
A handful of proteins implicated in neurodegenerative diseases have been found to produce pore-like amyloid structures known as annular protofibrils (APFs)
Tau annular protofibrils
pubmed:28420982
orcid:0000-0002-6117-4413
monoclonal antibody, named TOC1 (tau oligomeric complex 1), which selectively labels tau dimers and oligomers, but does not label filaments
TOC1
pubmed:22817713
orcid:0000-0002-6117-4413
fibrillar aggregates of alpha-synuclein, found in Lewy bodies
alpha-synuclein fibrils
pubmed:19892735
orcid:0000-0002-7128-929X
oligomeric aggregates of alpha-synuclein
alpha-synuclein oligomers
pubmed:17374364
orcid:0000-0002-7128-929X
the Lys-specific molecular tweezer CLR01 has been shown to inhibit aggregation and toxicity of multiple amyloidogenic protein
CLR01
pubmed:23183235
orcid:0000-0002-7128-929X
prefibrillar oligomers formed at early stages of α-syn assembly
prefibrillar α-synuclein oligomers
pubmed:27075649
orcid:0000-0002-7128-929X
Glyceraldehyde-derived (GA) advanced glycation end products
GA-AGE
pubmed:16630055
pubmed:15221334
orcid:0000-0001-9661-5277
Short isoform of tissue transglutaminase
TGM2 Isoform 3 (349 aa)
pubmed:12578227
uniprot.isoform:P21980-2
orcid:0000-0001-9661-5277
Conserved Tau phosphorylation motif. Part of the microtubule-binding region, phosphorylation of the serine in these motifs disrupts tau binding to the MT and serves to regulate tau-mediated MT assembly
KXGS motif
pubmed:17304350
pubmed:21215781
orcid:0000-0001-9661-5277
CBD is a late-onset neurodegenerative disease involving the cerebral cortex and the basal ganglia, characterized by widespread deposition of hyperphosphorylated 4-repeat tau in neurons and glia, the latter as astrocytic plaques
Corticobasal Degeneration
pubmed:22057784
orcid:0000-0001-9661-5277
Component of NFT, consisting in a helical arrangement of tau protomers
paired helical filaments
pubmed:1706519
pubmed:22496370
orcid:0000-0001-9661-5277
Component of NFT and ultrastructural polymorph of PHFs, with an assymetrical arrangement of the tau protomers
straight filaments
pubmed:28678775
pubmed:16566606
orcid:0000-0001-9661-5277
Murine IgM-class monoclonal antibody recognizing a specific conformational epitope adopted by tau during PHF formation
Alz50
pubmed:16566606
pubmed:8955115
orcid:0000-0001-9661-5277
A non-canonical glycosylation involving the attachment of single O-linked N-acetylglucosamine (O-GlcNAc) moieties to serine and threonine residues of cytoplasmic, nuclear, and mitochondrial proteins
O-GlcNAcylation
pubmed:16630055
orcid:0000-0001-9661-5277
The non-enzymatic reaction between the electrophilic carbonyl groups of a reducing sugar and the free amino groups of tau amino acids (especially of basic lysine or arginine residues) leading to the formation of a ketoamine (Amadori product), an intermediate of AGE synthesis.
glycation
pubmed:26655600
orcid:0000-0001-9661-5277
Incorporation of a nitrogen dioxide (NO2) group in tyrosine residues (mostly) of proteins forming 3-nitrotyrosine (3-NT). A biomarker of cell, tissue and systemic nitrosative stress.
nitration
pubmed:16566606
orcid:0000-0001-9661-5277
The reaction of polyamination by transglutaminases (TGs) involves a glutamine (Q) as acyl donor and a lysine (K) as acyl acceptor. It generates a (gamma)-glutamyl-(epsilon)-lysine isopeptide bond that causes protein cross-linking
polyamination
pubmed:25974414
orcid:0000-0001-9661-5277
The addition of a formyl functional group usually at the epsilon amino group of Lys residues
formylation
pubmed:21210655
orcid:0000-0001-9661-5277
IterPro:IPR001050
Syndecan Family
pubmed:15241784
orcid:0000-0002-0303-8616
The process of bacteria invading a cell
Bacterial invasion
pubmed:15241784
orcid:0000-0002-0303-8616
Dopmine secrete in a homeostatic way
dopamine homeostasis
pubmed:26325389
orcid:0000-0002-0303-8616
The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo.pubmed:23509287
PINK1-Park pathway
pubmed:26182419
orcid:0000-0002-0303-8616
The excitotoxicity of Glutamate
Glutamate excitotoxicity
pubmed:10196525
orcid:0000-0002-0303-8616
The interplay between mitophagy and mitochondrial biogenesis.
mitochondrial homeostasis
pubmed:25478815
orcid:0000-0002-0303-8616
reference:pubmed:22577383
ER mitochondria interorganellar crosstalk
pubmed:25478815
orcid:0000-0002-0303-8616
reference:pubmed:22399422
Mitochondrial pathway
pubmed:23313576
orcid:0000-0002-0303-8616
Oxidative protein folding is a process that is responsible for the formation of disulfide bonds between cysteine residues in proteins. The driving force behind this process is a redox reaction, in which electrons pass between several proteins and finally to a terminal electron acceptor.
oxidative protein folding
pubmed:26004228
orcid:0000-0002-0303-8616
The motility of mitochondria
mitochondrial motility
pubmed:25565208
orcid:0000-0002-0303-8616
The TIM/TOM complex is a protein complex in cellular biochemistry which translocates proteins produced from nuclear DNA through the mitochondrial membrane for use in oxidative phosphorylation. Only 13 proteins necessary for a mitochondrion are actually coded in mitochondrial DNA.
TIM/TOM complex
pubmed:25565208
orcid:0000-0002-0303-8616
The aggregation of mitochondria
mitochondrial aggregation
pubmed:25591737
orcid:0000-0002-0303-8616
The mevalonate pathway, also known as the isoprenoid pathway or HMG-CoA reductase pathway is an essential metabolic pathway present in eukaryotes, archaea, and some bacteria
mevalonate pathway
pubmed:24695221
orcid:0000-0002-0303-8616
UBERON:dopaminergic cell groups
Dopaminergic cell groups
pubmed:24695221
orcid:0000-0002-0303-8616
The precursor protein of mitochondria
mitochondrial precursor protein
pubmed:26192197
orcid:0000-0002-0303-8616
the nematode homolog of Parkin
PDR-1
pubmed:26430570
orcid:0000-0002-0303-8616
the nematode homolog of PINK1
PINK-1
pubmed:26430570
ncbigene:173918
wb:WBGene00017137
orcid:0000-0002-0303-8616
the nematode homolog of Skn1
skn-1
pubmed:25896323
orcid:0000-0002-0303-8616
the nematode homolog of Bcl-2
ced-9
pubmed:25896323
orcid:0000-0002-0303-8616
the nematode homolog of Lgg1
lgg-1
pubmed:25896323
orcid:0000-0002-0303-8616
the nematode homolog of Clec65
clec-65
pubmed:25896323
orcid:0000-0002-0303-8616
the nematode homolog of Clec4
clec-4
pubmed:25896323
orcid:0000-0002-0303-8616
exotoxin A is an exotoxin produced by Pseudomonas aeruginosa.It inhibits elongation factor-2. It does so by ADP-ribosylation of EF2. This then causes the elongation of polypeptides to cease.
exotoxin A
pubmed:25274306
orcid:0000-0002-0303-8616
mitochondrial damage-associated molecular patterns
mitochondrial DAMPs
pubmed:20203610
orcid:0000-0002-0303-8616
The IκB kinase is an enzyme complex that is involved in propagating the cellular response to inflammation.
IκB kinase
pubmed:19880420
fplx:IKK_family
orcid:0000-0002-0303-8616
Nonshivering thermogenesis was originally defined as a cold-induced increase in heat production not associated with the muscle activity of shivering. Recent research shows it to be a metabolic process located primarily in brown adipose tissue and controlled by the activity of the sympathetic nervous supply of this tissue
non-shivering thermogenesis
pubmed:6722594
pubmed:16224498
orcid:0000-0002-0303-8616
the nematode homologus of hsp16
hsp-16
pubmed:22700657
orcid:0000-0002-0303-8616
Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions. They were first described in relation to heat shock,
heat shock proteins
pubmed:15280428
mesh:D006360
orcid:0000-0002-0303-8616
Diets with high calorie.
high-calorie diets
pubmed:10412986
orcid:0000-0002-0303-8616
To function, proteins must undergo a folding process that gives them the proper three dimensional structure. Numerous genetic and biochemical observations suggest that proteins that fail to fold properly impair cell function. This process, also referred to as proteotoxicity, is particularly important to the fate of non-renewable cells of long-lived organisms in which malfolded proteins (proteotoxins) can exert their deleterious influence over extended periods of time.reference:Proteotoxicity and Aging
proteotoxicity
pubmed:24149988
orcid:0000-0002-0303-8616
A SNP located within the 3' UTR of FGF20, is significantly associated with PD risk
ss20399075
pubmed:15122513
orcid:0000-0002-0303-8616
The formation of alpha-synuclein oligmer
Alpha-synuclein Oligomerization
pubmed:21296890
orcid:0000-0002-0303-8616
A microsatellite markers for Alzheimer’s and Parkinson’s Diseases
D6S253
pubmed:9560156
orcid:0000-0002-0303-8616
A microsatellite markers for Alzheimer’s and Parkinson’s Diseases
D6S305
pubmed:9560156
orcid:0000-0002-0303-8616
In Parkinson's Disease, TT+AA is more frequent in MTHFR gene.
MTHFR,TT+AA
pubmed:17914182
orcid:0000-0002-0303-8616
CAG repeats in genes.
CAG repeats
pubmed:22782013
orcid:0000-0002-0303-8616
The function of gastrotestine disorder.
Gastrointestinal dysfunctions
pubmed:24467967
orcid:0000-0002-0303-8616
UBERON:olfactory epithelium
olfactory epithelium
pubmed:22691461
orcid:0000-0002-0303-8616
The nasal cycle is the often unnoticed alternating partial congestion and decongestion of the nasal cavities in humans and other animals. It is a physiological congestion of the nasal concha, also called the nasal turbinate, due to selective activation of one half of the autonomic nervous system by the hypothalamus.
nasal cycle
pubmed:23569018
orcid:0000-0002-0303-8616
Hyposmia is a reduced ability to smell and to detect odors.Hyposmia might be a very early sign of Parkinson's disease. Hyposmia is also an early and almost universal finding in Alzheimer's disease and dementia with Lewy bodies. Lifelong hyposmia could be caused by Kallmann syndrome.
hyposmia
pubmed:23933572
orcid:0000-0002-0303-8616
A premutation (PM) expansion (55-200 CGG) in the fragile X mental retardation gene 1 causes elevated messenger RNA and reduced fragile X mental retardation gene 1 protein.
FMR1,(55-200 CGG)
pubmed:24332449
orcid:0000-0002-0303-8616
a new member of the F-box family, Pof14, which forms a canonical
pof14
pubmed:17016471
orcid:0000-0002-0303-8616
MeSH Unique ID: D009457
Neuroglia
pubmed:19248803
mesh:D009457
orcid:0000-0002-0303-8616
The GDNF family of ligands (GFL) consists of four neurotrophic factors: glial cell line-derived neurotrophic factor (GDNF), neurturin (NRTN), artemin (ARTN), and persephin (PSPN). GFLs have been shown to play a role in a number of biological processes including cell survival, neurite outgrowth, cell differentiation and cell migration. In particular signalling by GDNF promotes the survival of dopaminergic neurons.
GDNF Family
pubmed:10383122
orcid:0000-0002-0303-8616
MeSH Unique ID: D009046
Motor Neurons
pubmed:10383122
mesh:D009046
orcid:0000-0002-0303-8616
Cell:noradrenergic neuron
noradrenergic neuron
pubmed:10383122
orcid:0000-0002-0303-8616
Cell:midbrain dopaminergic neuron
midbrain dopaminergic neuron
pubmed:10383122
orcid:0000-0002-0303-8616
A neurite or neuronal process refers to any projection from the cell body of a neuron.
Neurites
pubmed:23872421
mesh:D016501
orcid:0000-0002-0303-8616
BPS domain of protein GRB10
GRB10,BPS domain
pubmed:25268761
orcid:0000-0002-0303-8616
A chromosomal fragile site is a specific heritable point on a chromosome that tends to form a gap or constriction and may tend to break when the cell is exposed to partial replication stress.Based on their frequency, fragile sites are classified as common or rare.To date, more than 120 fragile sites have been identified in the human genome.
common fragile site
pubmed:12874785
orcid:0000-0002-0303-8616
The alpha helices of PARK7 protein
PARK7-alpha helices
pubmed:18707128
orcid:0000-0002-0303-8616
The cleaved part of Protein PINK1
cleaved PINK1
pubmed:21138942
orcid:0000-0002-0303-8616
The brain hyperaemia, or coupling, is accomplished by a group of cells, closely related to each other; called neurovascular unit (NVU). The neurovascular unit is composed by neurones, astrocytes, endothelial cells of blood-brain barrier (BBB), myocytes, pericytes and extracellular matrix components
neurovascular unit
pubmed:24629161
pubmed:25136294
orcid:0000-0002-0303-8616
MeSH Unique ID: D009132
Muscles
pubmed:21151955
mesh:D009132
orcid:0000-0002-0303-8616
MeSH Unique ID: D058953
Neural Stem Cell
pubmed:22357600
mesh:D058953
orcid:0000-0002-0303-8616
MeSH Unique ID: D017557
Ventral Tegmental Area
pubmed:16190884
mesh:D017557
orcid:0000-0002-0303-8616
MeSH Unique ID: D065842
Pars Compacta
pubmed:16190884
mesh:D065842
orcid:0000-0002-0303-8616
Correspounding to residues I151 to Q244 of the 441 aa tau isoform, separated into P1 and P2. Possible role in tau's functional stabilization through the reported intramolecular interaction of P2 with R1, R2 and R4 from the microtubule-binding region
proline-rich domain
P domain
PRD
pubmed:25974414
pubmed:8068626
pubmed:9190213
orcid:0000-0001-9661-5277
the nematode homolog of Lys2
lys-2
pubmed:25896323
orcid:0000-0003-4423-4370
the nematode homolog of Abf2
abf-2
pubmed:25896323
orcid:0000-0003-4423-4370
The lower cleft between domains 1 and 3 is lined by residues Tyr143, Ala144, Gly146, Thr148, Gly168, Ile341, Ile345, Leu346, Leu349, Thr351, and Met355, which are predominantly hydrophobic. This cleft constitutes the major binding site for most ABPs and also mediates important longitudinal contacts between actin subunits in the filament
hydrophobic pocket of actin
pubmed:21314430
orcid:0000-0002-6117-4413
The 310-helix is the fourth most common type of secondary structure in proteins after α-helices, β-sheets, and reverse turns (Barlow and Thornton 1988). Approximately 15%–20% of all helices in protein structures are 310-helices, which are commonly found as N- or C-terminal extensions to an α-helix (Barlow and Thornton 1988). 310-Helices in proteins are typically only three to five residues long compared with a mean of 10–12 residues for α-helices (Richardson and Richardson 1988)
310-helix
pubmed:12761385
orcid:0000-0002-6117-4413
Amino Acid Sequence: Ac-Leu-Gly-Arg-Leu-Ser-Gln-Glu-Leu-His-Arg-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2
Amylin Antagonist AC253
pubmed:22500019
orcid:0000-0002-3034-9970
The cyclin dependent kinase 5 regulatory subunit 1 (CDK5R1), also known as p35, is cleaved by Calpain to produce the p25 fragment
CDK5R1 p25
pubmed:10830966
orcid:0000-0002-3034-9970
p(HGNC:CDK5R1, frag(99_307))
PTI-125 is a proprietary small molecule that preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its alpha7nAChR/TLR4 associations and downstream pathologies
PTI-125
pubmed:28438486
pubmed:22815492
orcid:0000-0002-6117-4413
In addition to nAChRs forming from different subunit assemblages, stoichiometric study has shown that α4β2 nAChRs can form as either (α4)3(β2)2 or (α4)2(β2)3, the latter having a greater affinity for both nicotine and Ach
alpha-4 beta-2 nAChR
pubmed:24828779
orcid:0000-0002-6117-4413
Accumulating evidence demonstrates that these α7 and β2 nAChR subunits can co-assemble to form functional α7β2 nAChRs in heterologous expression systems, and also under natural conditions in the brain (Figure 1)
alpha-7 beta-2 nAChR
pubmed:27179601
orcid:0000-0002-6117-4413
The β2 subunit can couple with non-α4 subunits, including α2, α3 and α6 subunits to form functionally distinct nAChRs, but these receptors are much less densely expressed in the central nervous system relative to α4β2* nAChRs (*indicating potential assemblage of β2 subunits with non-α4 subunits)
beta-2-containing nAChR
pubmed:24828779
orcid:0000-0002-6117-4413
56 kDa soluble amyloid-β (Aβ) assembly
Abeta*56
pubmed:16541076
orcid:0000-0002-3034-9970
Aggregates of proteins or fragments of proteins
protein aggregates
pubmed:23484434
pmc:PMC2633703
pubmed:23254192
pubmed:12747895
mesh:D066329
sbo:SBO:0000543
orcid:0000-0003-4423-4370
results from the cleavage of beta APP by gamma-secretase
sAPP-gamma
pubmed:12105112
orcid:0000-0002-3034-9970
alpha6-containing receptors, which in brain occur as heteropentamers with beta2 and beta3 and are especially enriched in presynaptic nerve terminals in striatum (Champtiaux et al.,2002)
alpha-6-containing nAChR
pubmed:28445721
pubmed:19498417
orcid:0000-0002-6117-4413
Tau domain located in the N-terminal region encompassing residues 2-18. It activates phosphatase PP1 which dephosphorylates Ser9 in GSK3Beta and leads to its activation. In normal tau, both NTD and CTD are folded back in proximity to each other forming a 'paper-clip' conformation, which masks the PAD. Phosphorylation in the AT8 epitope, disrupts this normal conformational state, exposing the PAD by moving away the terminal domains.
phosphatase-activating domain
pubmed:28413156
pubmed:26671985
orcid:0000-0001-9661-5277
Autocatalytic cysteine-mediated acetylation of Lys residues in the MTBR upon incubation of tau proteins with acetyl-CoA, possible even in absence of enzymatic activity.This activity may be suppressed when tau is bound to tubulin or MTs, but activated upon tau dissociation during pathological conditions that abrogate tau-MT interactions, thus allowing acetyl-CoA accessibility to free tau cysteines.
cystein-dependent auto-acetylation
pubmed:27383765
pubmed:28002468
orcid:0000-0001-9661-5277
Pathological hallmarks of Alzheimer Disease, consisting in intraneuronal accumulations of large membrane-bound vacuoles. Associated with the late stages of disease progression, they were also shown to be immunopositive or GSK3Beta and SYK (Spleen Tyrosine Kinase).
GVD bodies
pubmed:26501932
orcid:0000-0001-9661-5277
Advanced glycation end products (AGEs) are the production of Maillard reaction between carbohydrates and proteins. They cause neurotoxicity via production of ROS followed by an increase in expression of APP and amyloid beta. Recent analysis implicates them in tau phosphorylation.
advanced glycation end product
pubmed:28176663
orcid:0000-0001-9661-5277
A long lasting enhancement in synaptic transmission between two neurons, most commonly studied in the synapse between the Schaffer collateral axons of the CA3 neurons and the CA1 pyramidal neurons of the hippocampus. Alongside the LTD (long-term depression) represent the two mechanisms of memory formation and storage. Impairment of this process in AD is caused by soluble oligmoeric amyloid beta.
long-term potentiation
pubmed:27041503
mesh:D017774
orcid:0000-0001-9661-5277
Part of the wider proline-rich domain, divided between the projection and assembly domains, this region together with the MTBR mediate tau interaction and binding to F actin.
proline-rich region 1
pubmed:21757739
orcid:0000-0001-9661-5277
Part of the wider proline-rich domain, divided between the projection and assembly domains, this region together with the MTBR mediate tau interaction and binding to F actin.
proline-rich region 2
pubmed:21757739
orcid:0000-0001-9661-5277
Tau assembly domain consists of the second part of the proline-rich region (PR2), MTBR and CTD, corresponding to residues 199-441 of the canonical tau isoform.
assembly domain
pubmed:21757739
orcid:0000-0001-9661-5277
Cullin-RING E3 ubiquitin ligase complex 4, consisting of CUL4(A,B), DDB1 and CRBN.
CRL4 complex
pubmed:27325702
orcid:0000-0001-9661-5277
Cytosolic region of APP, responsible for interacting with E3 ubiquitin ligases among other proteins.
APP, ACR
pubmed:27325702
orcid:0000-0001-9661-5277
Detyrosination is a form of posttranslational modification that occurs on alpha-tubulin. It consists of the removal of the C-terminal tyrosine to expose a glutamate at the newly formed C-terminus. Promoted by Tau truncation in the Gln124 residue.
tubulin detyrosination
pubmed:25974414
orcid:0000-0001-9661-5277
An intense reaction of microglia following CNS insult, characterized by active proliferation and retracted cellular processes. In AD, accumulation of Abeta can be a possible cause of such physiological phenomenon, as microglia is seen surrounding senile plaques. Abeta interaction with microglial pattern recognition receptors (PRRs) leads to NLRP3 inflammasome activation, production of toxic NOS and ROS and release of proinflammatory cytokines.
Microgliosis
pubmed:29121589
orcid:0000-0001-9661-5277
Morphological and functional changes observed in astrocytes in the context of their physiological response to CNS trauma or injury caused by ischemia, stroke, autoimmune disorders and neurodegeneration.
Astrogliosis
pubmed:29121589
orcid:0000-0001-9661-5277
The CK1 group of eukaryotic protein kinases are composed of seven CK1 isoforms (CK1α, CK1α2, CK1δ, CK1ε, CK1γ1, CK1γ2, and CK1γ3), two Tau–tubulin kinase isoforms (TTBK1 and TTBK2), and three VRK isoforms (VRK1, VRK2, and VRK3)
CK1 superfamily
pubmed:25673844
orcid:0000-0001-9661-5277
nAChRs that bind radiolabeled nicotine with the highest affinity contain a4 subunits (a4*-nAChR)
alpha-4-containing nAChR
pubmed:21787755
orcid:0000-0002-7128-929X
a4 subunits can also assemble with b4 subunits to form a4b4-nAChRs that have comparably high nicotine affinity
alpha-4 beta-4 nAChR
pubmed:21787755
orcid:0000-0002-7128-929X
Another prominent nAChR subtype found in vertebrate central and autonomic nervous systems contains a7 subunits.
alpha-7-containing nAChR
pubmed:21787755
orcid:0000-0002-7128-929X
Neurotoxic proteins from the venom of the banded or Formosan krait (Bungarus multicinctus, an elapid snake).
alpha-Bungarotoxin
pubmed:21787755
uniprot:P60616
orcid:0000-0002-7128-929X
nAChRs containing the a3b2 subunit interface
alpha-3 beta-2 nAChR
pubmed:21787755
orcid:0000-0002-7128-929X
kappa-Bungarotoxin, a snake venom kappa-neurotoxin, is a potent neuronal nicotinic receptor antagonist (pubmed:3359187)
kappa-Bungarotoxin
pubmed:3359187
pubmed:21787755
uniprot:P01398
orcid:0000-0002-7128-929X
highly selective M4 (mAChR) allosteric potentiator. Chemical name: 3-Amino-N-[(4-chlorophenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
VU10010
2-Fly
2-Furoyl-LIGRLO-amide trifluoroacetate salt
2-Furoyl-LIGRLO-amide trifluoroacetate salt, >=97% (HPLC)
2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2 trifluoroacetate salt
2-f-LIGRLO-NH2
2-fAP
2fLI
3-Amino-N-(4-chlorobenzyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide 2,2,2-trifluoroacetate
3-amino-N-(4-chlorobenzyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
3-amino-N-[(4-chlorophenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
633283-39-3
A3274/0139289
AC1LEM0C
AKOS000282930
B7285
BDBM50323691
CHEMBL1212994
CTK5B8654
D0N2VN
DTXSID30351931
FPRULFHDSFKYBV-UHFFFAOYSA-N
HMS3431D09
KB-81468
MCULE-8947006791
MLS002474501
MolPort-002-722-568
NCGC00378784-01
RT-016241
SMR001398666
SR-01000147542
SR-01000147542-1
STL227650
VU 10010
VU-10010
VU0402469-1
VU10010
ZINC109066
cid_714286
f-LIGRLO-NH2
pubmed:18059262
pubmed:24511233
cas:633283-39-3
inchi:InChI=1S/C17H16ClN3OS/c1-9-7-10(2)21-17-13(9)14(19)15(23-17)16(22)20-8-11-3-5-12(18)6-4-11/h3-7H,8,19H2,1-2H3,(H,20,22)
pubchem.compound:714286
smiles:CC1=C2C(SC(C(NCC3=CC=C(Cl)C=C3)=O)=C2N)=NC(C)=C1
orcid:0000-0002-6117-4413
M1-selective PAM that potentiates M1 (mAChR). Chemical name:1-[4,6-difluoro-1-[6-(1-methylpyrazol-4-yl)pyridin-3-yl]indol-3-yl]sulfonyl-3-(5-methyl-1,2-oxazol-3-yl)propan-2-one
VU0456940
VU 0456940
VU-0456940
VU0456940
pubmed:24511233
inchi:InChI=1S/C24H19F2N5O4S/c1-14-5-17(29-35-14)8-19(32)13-36(33,34)23-12-31(22-7-16(25)6-20(26)24(22)23)18-3-4-21(27-10-18)15-9-28-30(2)11-15/h3-7,9-12H,8,13H2,1-2H3
iupac:1-[4,6-difluoro-1-[6-(1-methylpyrazol-4-yl)pyridin-3-yl]indol-3-yl]sulfonyl-3-(5-methyl-1,2-oxazol-3-yl)propan-2-one
smiles:CN1N=CC(C2=CC=C(N3C=C(S(=O)(CC(CC4=NOC(C)=C4)=O)=O)C5=C3C=C(F)C=C5F)C=N2)=C1
orcid:0000-0002-6117-4413
selective M4 (mAChR) allosteric potentiator. Chemical name: 3-Amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
VU0152099
3-amino-4,6-dimethyl-N-piperonyl-thieno[2,3-b]pyridine-2-carboxamide
3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethyl-2-thieno[2,3-b]pyridinecarboxamide
3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[5,4-b]pyridine-2-carboxamide
3-amino-N-(2H-1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
3-amino-N-(benzo[d][1,3]dioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine carboxamide
3-azanyl-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxamide
612514-42-8
AC1LTW64
AC1Q2P5R
AKOS002170228
BDBM48044
D0Y1VB
GTPL3256
HMS3843E06
MCULE-6171593814
MLS002474500
MolPort-000-437-290
Oprea1_621562
SMR001398665
STK207844
VU0152099
VU0152099-1
ZINC1472126
cid_1541501
pubmed:24511233
inchi:InChI=1S/C18H17N3O3S/c1-9-5-10(2)21-18-14(9)15(19)16(25-18)17(22)20-7-11-3-4-12-13(6-11)24-8-23-12/h3-6H,7-8,19H2,1-2H3,(H,20,22)
pubchem.compound:1541501
smiles:CC1=CC(=NC2=C1C(=C(S2)C(=O)NCC3=CC4=C(C=C3)OCO4)N)C
wikidata:Q27089173
orcid:0000-0002-6117-4413
selective M1(mAChR)-PAM. Chemical name: 2-(4-Ethoxyanilino)-N'-[(Z)-(2-oxonaphthalen-1-ylidene)methyl]acetohydrazide
VU0029767
2-(4-ethoxyanilino)-N'-[(E)-(2-oxonaphthalen-1-ylidene)methyl]acetohydrazide
2-[(4-ethoxyphenyl)amino]-N'-[(2-hydroxy-1-naphthyl)methylene]acetohydrazide (non-preferred name)
326001-01-8
AKOS028114549
AOB2484
BCP17383
D0L5AG
KS-000046FP
ZINC1204219
ZINC38534584
pubmed:24590577
inchi:InChI=1S/C21H21N3O3/c1-2-27-17-10-8-16(9-11-17)22-14-21(26)24-23-13-19-18-6-4-3-5-15(18)7-12-20(19)25/h3-13,22-23H,2,14H2,1H3,(H,24,26)
pubchem.compound:6758210
smiles:CCOC1=CC=C(C=C1)NCC(=O)NNC=C2C(=O)C=CC3=CC=CC=C32
orcid:0000-0002-6117-4413
selective M1(mAChR)-PAM. Chemical name: Cyclopentyl 3,4-dimethyl-6-(6-nitro-1,3-benzodioxol-5-yl)-2-oxo-1,6-dihydropyrimidine-5-carboxylate
VU0090157
AC1MER3E
AKOS001633711
AKOS022078796
BIM-0042576.P001
CBMicro_042727
D0O6BD
EU-0038260
GTPL3259
MCULE-4339280714
MolPort-002-181-662
Oprea1_103541
SR-01000433423
SR-01000433423-1
STK079398
UNM000000551301
VU0090157
cyclopentyl 1,6-dimethyl-4-(6-nitro-1,3-benzodioxol-5-yl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
cyclopentyl 1,6-dimethyl-4-(6-nitro-1,3-benzodioxol-5-yl)-2-oxo-3,4-dihydropyrimidine-5-carboxylate
cyclopentyl 1,6-dimethyl-4-(6-nitrobenzo[d][1,3]-dioxol-5-yl)-2-oxo-1,2,3,4 tetrahydropyrimidine-5-carboxylate
cyclopentyl 1,6-dimethyl-4-(6-nitrobenzo[d][1,3]-dioxol-5-yl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
cyclopentyl 3,4-dimethyl-6-(6-nitro-1,3-benzodioxol-5-yl)-2-oxo-1,6-dihydropyrimidine-5-carboxylate
pubmed:24590577
inchi:InChI=1S/C19H21N3O7/c1-10-16(18(23)29-11-5-3-4-6-11)17(20-19(24)21(10)2)12-7-14-15(28-9-27-14)8-13(12)22(25)26/h7-8,11,17H,3-6,9H2,1-2H3,(H,20,24)
pubchem.compound:2882724
smiles:CC1=C(C(NC(=O)N1C)C2=CC3=C(C=C2[N+](=O)[O-])OCO3)C(=O)OC4CCCC4
orcid:0000-0002-6117-4413
M1(mAChR) allosteric agonists. Chemical name: Ethyl 4-(2-benzamidoethylamino)piperidine-1-carboxylate hydrochloride
VU0184670
1135241-95-0
CHEMBL1535797
MLS002279950
SMR001318088
VU0184670
ethyl 4-(2-benzamidoethylamino)piperidine-1-carboxylate hydrochloride
pubmed:24590577
chembl:CHEMBL1535797
inchi:InChI=1S/C17H25N3O3.ClH/c1-2-23-17(22)20-12-8-15(9-13-20)18-10-11-19-16(21)14-6-4-3-5-7-14;/h3-7,15,18H,2,8-13H2,1H3,(H,19,21);1H
pubchem.compound:25010774
smiles:CCOC(=O)N1CCC(CC1)NCCNC(=O)C2=CC=CC=C2.Cl
orcid:0000-0002-6117-4413
Inhibits Fyn localization in lipid rafts and subsequently inhibits the fyn-dependent Abeta redistribution and accumulation in lipid rafts, process linked with ADDL-induced cell death.
2-Bromohexadecanoic acid
.alpha.-Bromopalmitic acid
18263-25-7
2-Bromohexadecanoic acid
2-Bromohexadecanoic acid, >=99.0% (GC)
2-Bromohexadecanoic acid, purum, >=97.0% (GC)
2-Bromohexadecanoic acid, ~97%
2-Bromopalmitate
2-Bromopalmitic acid
2-bromanylhexadecanoic acid
2-bromo-hexadecanoic acid
2-bromopalmitate, (+-)-isomer
40305-76-8
A812715
AC1L32UD
AC1Q2444
ACM18263257
ACMC-1C7OL
AKOS003404931
AKOS017343270
BDBM50148454
C-20189
C16H31BrO2
CAS-18263-25-7
CC-09685
CHEBI:133152
CHEMBL118417
CTK4D8252
DB-044471
DPRAYRYQQAXQPE-UHFFFAOYSA-N
DSSTox_CID_17734
DSSTox_GSID_37734
DSSTox_RID_79368
DTXSID0037734
EINECS 242-137-0
FT-0611564
Hexadecanoic acid, 2-bromo-
Hexadecanoic acid,2-bromo-
I04-8986
J-011689
KB-68336
L213
LMFA01090011
LS-174823
MCULE-7613431163
MFCD00004215
MolPort-001-759-724
NCGC00164251-01
NCGC00164251-02
NCGC00254935-01
NCIOpen2_007723
NSC 58378
NSC-58378
NSC58378
OR10833
SBB071635
SCHEMBL97565
ST45026694
TC-170832
TRA0083226
Tox21_301033
VZ24096
ZX-AT022731
alpha-Bromopalmitic acid
bromohexadecanoic acid
pubmed:18096814
chebi:CHEBI:133152
inchi:InChI=1S/C16H31BrO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(17)16(18)19/h15H,2-14H2,1H3,(H,18,19)
pubchem.compound:82145
smiles:CCCCCCCCCCCCCCC(C(=O)O)Br
orcid:0000-0001-9661-5277
The catalytic core of the 26 S proteasome system, responsible for tau degradation
20 S Proteasome
pubmed:17954934
pubmed:19145068
orcid:0000-0001-9661-5277
An oxidation product consisting of covalent ortho-ortho coupling between two tyrosine residues formed as a conseguence to UV irradiation, gamma-irradiation, aging, exposure to oxygen free radicals, nitrogen dioxide, peroxynitrite, and lipid hydroperoxides. ROS catalyzed by Cu ions are involved in the generation of these cross-links in amyloid beta oligomers to which they provide stability. Also involved in the stabilization of tau PHF. A potential biomarker of oxidative stress in AD.
3-3 dityrosine cross-linking
pubmed:16566606
pubmed:24351276
orcid:0000-0001-9661-5277
A disease propagation and progression model, composed of six stages of increasing pathological severity determined by the location of the tangle-bearing neurons and the amplitude of the pathophysiological changes. Transentorhinal stages I-II: correspond to clinically silent cases of very mildly affected subjects, showing no cognitive impairment. NFT are slowly and gradually developping.
Braak_Stage I
pubmed:7566337
pubmed:28176663
orcid:0000-0001-9661-5277
A disease propagation and progression model, composed of six stages of increasing pathological severity determined by the location of the tangle-bearing neurons and the amplitude of the pathophysiological changes. Transentorhinal stages I-II: correspond to clinically silent cases of very mildly affected subjects, showing no cognitive impairment. NFT are slowly and gradually developping.
Braak_Stage II
pubmed:7566337
pubmed:28176663
orcid:0000-0001-9661-5277
A disease propagation and progression model, composed of six stages of increasing pathological severity determined by the location of the tangle-bearing neurons and the amplitude of the pathophysiological changes.Limbic stages III-IV designate an incipient Alzheimer's disease, since due to the lack of neocortical destruction, stages III and IV do not meet the currently used criteria for neuropathologic diagnosis of AD. Stage III is characterised by the destruction of the external principal stratum of the entorhinal laminae presenting considerable amounts of NFT and neuropil threads.
Braak_Stage III
pubmed:7566337
orcid:0000-0001-9661-5277
A disease propagation and progression model, composed of six stages of increasing pathological severity determined by the location of the tangle-bearing neurons and the amplitude of the pathophysiological changes.Limbic stages III-IV designate an incipient Alzheimer's disease, since due to the lack of neocortical destruction, stages III and IV do not meet the currently used criteria for neuropathologic diagnosis of AD. Stage IV is characterised by the destruction of the internal principal stratum of the entorhinal laminae presenting considerable amounts of NFT and neuropil threads. The destruction of entorhinal cellular layers interferes with the normal transfer of information between neocortex and hippocampus, manifesting as cognitive impairment and subtle personality changes.
Braak_Stage IV
pubmed:7566337
orcid:0000-0001-9661-5277
A disease propagation and progression model, composed of six stages of increasing pathological severity determined by the location of the tangle-bearing neurons and the amplitude of the pathophysiological changes.neocortical stages V-VI correspond to fully developed Alzheimer's disease. These stages are characterized by large numbers of NFTs in all sections of cerebral cortex and present neocortical damage thus contributing to the development of the conventional neuropathological criteria for the clinical diagnosis of AD.
Braak_Stage V
pubmed:7566337
pubmed:28176663
orcid:0000-0001-9661-5277
A disease propagation and progression model, composed of six stages of increasing pathological severity determined by the location of the tangle-bearing neurons and the amplitude of the pathophysiological changes.neocortical stages V-VI correspond to fully developed Alzheimer's disease. These stages are characterized by large numbers of NFTs in all sections of cerebral cortex and present neocortical damage thus contributing to the development of the conventional neuropathological criteria for the clinical diagnosis of AD.
Braak_Stage VI
pubmed:7566337
orcid:0000-0001-9661-5277
A peptide with sequence:GFPLKRHDGVDDLSKVG, originally synthesized by Helicobacter Pylori acting as a specific MARK kinase inhibitor, decreasing tau phosphorylation
CagA peptide
pubmed:23666762
pubmed:19966800
orcid:0000-0001-9661-5277
Shortest isoform of Microtubule affinity regulating kinase 4 (MARK4) derived from alternatvie splicing. It is upregulated during the early stages of neuron differentiation.
MARK4 isoform 2 (688 aa)
pubmed:16973293
uniprot.isoform:Q96L34-2
orcid:0000-0001-9661-5277
Loss of function mutant of DYRK1A isoform 1
NP_001387.2:p.Arg205del
pubmed:28167836
orcid:0000-0001-9661-5277
Loss of function mutant of DYRK1A isoform 1
NP_001387.2:p.Glu239del
pubmed:28167837
orcid:0000-0001-9661-5277
Prion protein fragment 106-126. This peptide increases membrane microviscosity, intracellular Ca2+ concentration and cell migration in circulating leucocytes, and oxygen production in monocytes and neutrophils. It also induces apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in the GH3 cell lines. PrP (106–126) stimulates leucocyte migration in a dose-dependent manner. Inhibits tau phosphorylaton at Ser262. Seq = KTNMKHMAGAAAAGAVVGGLG
PrP106-126
pubmed:22692785
orcid:0000-0001-9661-5277
The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.
Purkinje cell layer of cerebellar cortex
pubmed:29221819
orcid:0000-0001-9661-5277
Tau antibody with specificity for pSer262
Tau antibody, AGG5759
pubmed:23666762
orcid:0000-0001-9661-5277
Tau murine monoclonal antibody with specificity for pSer262
Tau antibody, Tau-13
pubmed:23666762
orcid:0000-0001-9661-5277
Tau epitope consisting of pSer262 and pSer356
Tau epitope, 12E8
pubmed:22156579
orcid:0000-0001-9661-5277
Tau epitope consisting of pThr231
Tau epitope, AT180
pubmed:22833681
orcid:0000-0001-9661-5277
Tau epitope consisting of pSer202, pThr205, pSer208, pSer199
Tau epitope, AT8
pubmed:18239272
orcid:0000-0001-9661-5277
Tau epitope consisting of pSer202
Tau epitope, CP13
pubmed:25331948
orcid:0000-0001-9661-5277
Tau epitope consisting of pSer396, pSer404
Tau epitope, PHF1
pubmed:22156579
orcid:0000-0001-9661-5277
Dysfunctional axons and terminals that accumulate the β-site amyloid precursor protein (APP) cleaving enzyme (BACE1) required for Aβ generation.
dystrophic neurite
pubmed:28877763
orcid:0000-0001-9661-5277
The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer
granular layer of cerebellar cortex
pubmed:29221819
orcid:0000-0001-9661-5277
The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells
molecular layer of cerebellar cortex
pubmed:29221819
orcid:0000-0001-9661-5277
Isoform of KALRN protein
Kalirin 7
pubmed:27796283
orcid:0000-0001-9661-5277
Tauopathies characterized by a relatively higher presence of the 4R tau isoforms, such as Alzheimers Disease and Corticobasal Degeneration
4R tauopathy
pubmed:21427723
orcid:0000-0001-9661-5277
Ricolinostat is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity. Ricolinostat selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation. This leads to an accumulation of unfolded and misfolded ubiquitinated proteins and may eventually induce cancer cell apoptosis, and inhibition of cancer cell growth. HDAC6, a class II HDAC deacetylase located in the cytoplasm, appears to play a key role in the formation and activation of the aggresomes needed for degradation of misfolded proteins. Compared to non-selective HDAC inhibitor, ACY-1215 is able to reduce the toxic effects on normal, healthy cells.
ACY-1215
1316214-52-4
2-(Diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide
2-(Diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide
2-(diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]pyrimidine-5-carboxamide
5-Pyrimidinecarboxamide, 2-(diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)-
5-Pyrimidinecarboxamide, 2-(diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-
7-{[2-(DIPHENYLAMINO)PYRIMIDIN-5-YL]FORMAMIDO}-N-HYDROXYHEPTANAMIDE
A11940
AB0032517
AC-30258
ACN-030031
ACY-1215
ACY-63
ACY1215
AH4
AJ-128539
AK151416
AKOS024259260
AX8288032
BC600387
BCP06028
BDBM50439674
CHEBI:95073
CHEMBL2364628
CS-0965
D0TP9M
D10661
DB12376
DTXSID40157148
EX-A139
GTPL7010
HMS3653F17
HY-16026
J-690127
KB-74507
KS-00000SAV
MFCD22666356
MLS006011181
MolPort-028-600-031
N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)pyrimidine-5-carboxamide
NCGC00345802-01
NCGC00345802-05
Ricolinostat
Ricolinostat (ACY-1215)
Ricolinostat (USAN/INN)
Ricolinostat [USAN:INN]
Rocilinostat
Rocilinostat (ACY-1215)
SB17054
SCHEMBL574580
SMR004702950
ST24039648
SW219836-1
UNII-WKT909C62B
US8609678, 2-(diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide [26]
W-5979
WKT909C62B
X5832
ZINC89630354
rocilinostat-acy-1215
s8001
pubmed:24844691
cas:1316214-52-4
chebi:CHEBI:95073
drugbank:DB12376
inchi:InChI=1S/C24H27N5O3/c30-22(28-32)15-9-1-2-10-16-25-23(31)19-17-26-24(27-18-19)29(20-11-5-3-6-12-20)21-13-7-4-8-14-21/h3-8,11-14,17-18,32H,1-2,9-10,15-16H2,(H,25,31)(H,28,30)
mesh:C572255
pubchem.compound:53340666
smiles:C1=CC=C(C=C1)N(C2=CC=CC=C2)C3=NC=C(C=N3)C(=O)NCCCCCCC(=O)NO
orcid:0000-0001-9661-5277
Interacts with tubulin binding repeat 1
APOE e3
pubmed:26751493
orcid:0000-0001-9661-5277
A cell-permeable imidazopyrimidine compound that acts a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC50 = 10 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src even at concentrations as high as 4.7 µM. Shown to inhibit Syk-mediated cellular functions in vitro and exhibit good oral bioavailability and in vivo effacacy in the treatment of various allgery and asthma conditions in rat models. Indirect inhibitory effect on GSK3B activity
BAY61-3606
2-((7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl)amino)nicotinamide
2-(7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-ylamino)nicotinamide hydrochloride
2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide
2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidine-5-yl]amino]-3-pyridinecarboxamide
2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide
3-Pyridinecarboxamide, 2-((7-(3,4-dimethoxyphenyl)imidazo(1,2-C)pyrimidin-5-yl)amino)-
61G8S0H9KX
732983-37-8
A11320
AC-29888
ACN-053214
AKOS030526888
BAY 61-3606
BAY 61-3606 HCl
BAY-61-360
BAY-61-3606 free base
BAY-613606
BAY61-3606
BCP08946
BDBM50325991
BRD-K53281329-001-01-9
CCG-102604
CHEBI:91426
CHEMBL1190711
CHEMBL1242100
CS-0235
EX-A1437
GTPL9693
HY-76474
J-507625
KB-74859
Kinome_3125
NCGC00346945-01
NCGC00346945-06
RL04784
SCHEMBL373774
Syk inhibitor IV
UNII-61G8S0H9KX
ZINC3817793
cc-526
pubmed:25331948
cas:732983-37-8
chebi:CHEBI:91426
inchi:InChI=1S/C20H18N6O3/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19/h3-11H,1-2H3,(H2,21,27)(H,23,24,25)
mesh:C477642
pubchem.compound:10200390
smiles:COC1=C(C=C(C=C1)C2=CC3=NC=CN3C(=N2)NC4=C(C=CC=N4)C(=O)N)OC
wikidata:Q27163275
orcid:0000-0001-9661-5277
Chemical compund group acting as inhibitors of HDAC family proteins.
Biphenyl-4-yl-acrylohydroxamoc acids
pubmed:26890116
orcid:0000-0001-9661-5277
Ectorhinal area 36 is a subdivision of the cytoarchitecturally defined temporal region of cerebral cortex. With its medial boundary corresponding approximately to the rhinal sulcus it is located primarily in the fusiform gyrus. Cytoarchitecturally it is bounded laterally and caudally by the inferior temporal area 20, medially by the perirhinal area 35 and rostrally by the temporopolar area 38 (H) (Brodmann-1909). Together with Brodmann area 35, it comprises the perirhinal cortex.
Brodmann (1909) area 36
pubmed:23407988
orcid:0000-0001-9661-5277
PCAF and NFkappaB inhibitor, showed anti-inflammatory properties and improved cognition
C-30-27
pubmed:25672970
inchi:InChI=1S/C20H26ClN3O3/c1-25-19-13-16(14-22-6-7-24-8-10-26-11-9-24)12-18(21)20(19)27-15-17-4-2-3-5-23-17/h2-5,12-13,22H,6-11,14-15H2,1H3
smiles:C1COCCN1CCNCC2=CC(=C(C(=C2)Cl)OCC3=CC=CC=N3)OC
orcid:0000-0001-9661-5277
Inhibitor of EP300 acetylase
C646
(E)-4-(4-((5-(4,5-diMethyl-2-nitrophenyl)furan-2-yl)Methylene)-3-Methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
328968-36-1
4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
4-[(4E)-4-[[5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
4-[(4E)-4-{[5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl]methylidene}-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid
AC1LPE4S
AKOS005418912
AOB5549
BC600370
BRD-K68548958-001-01-2
C 646
C-646
C646
CHEMBL3734823
CS-3529
EX-A1063
HY-13823
KB-145969
MolPort-002-976-806
SCHEMBL14991291
STK219801
ZINC13838357
pubmed:20869593
inchi:InChI=1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12+
pubchem.compound:1285940
smiles:CC1=C(C=C(C(=C1)C2=CC=C(O2)C=C3C(=NN(C3=O)C4=CC=C(C=C4)C(=O)O)C)[N+](=O)[O-])C
orcid:0000-0001-9661-5277
Part of hippocampus proper bounded by CA2 and the subiculum, characterized by pyramidal neurons that receive projections from pyramidal neurons of CA3 via the Schaffer collaterals.
CA1 field of hippocampus
pubmed:23407988
mesh:D056547
orcid:0000-0001-9661-5277
Part of hippocampus proper bounded by areas CA3 and CA1, characterized by a narrow layer of large pyramidal cells, similar in size to CA3 pyramidal cells, but which lack the mossy fiber input from the dentate gyrus
CA2 field of hippocampus
pubmed:23407988
mesh:D056651
orcid:0000-0001-9661-5277
Part of hippocampus proper bounded by the hilus of the dentate gyrus and area CA2, characterized by large pyramidal cells and a dense projection from dentate gyrus granule cell mossy fibers.
CA3 field of hippocampus
pubmed:23407988
mesh:D056654
orcid:0000-0001-9661-5277
The last of four regions in the cornu ammonis of the hippocampus and is also part of the hilus of the dentate gyrus. This area contains mostly mossy cells that receive inputs from the dentate gyrus and pyramidal cells in the CA3 region and also projects back to the dentate gyrus.
CA4 field of hippocampus
pubmed:23407988
orcid:0000-0001-9661-5277
Inhibitor of GAPDH nitrosylation, abrogated Abeta induced tau acetylation and subsequent pathological impairments related to AD
CGP3466B
(Dibenzo(b,f)oxepin-5-ylmethyl)(methyl)prop-2-yn-1-amine
181296-84-4
5V14HD0N4Q
634202-78-1
AC1O4WBX
CGP 3466
CGP-3466
CGP-3499B
CHEBI:41778
CHEMBL1232111
D06KSV
DB12879
DTXSID10171098
Dibenzo(b,f)oxepin-10-ylmethyl-methyl-prop-2-ynylamine
N-(DIBENZO[B,F]OXEPIN-10-YLMETHYL)-N-METHYL-N-PROP-2-YNYLAMINE
N-(benzo[b][1]benzoxepin-5-ylmethyl)-N-methylprop-2-yn-1-amine
N-(dibenzo[b,f]oxepin-10-ylmethyl)-N-methylprop-2-yn-1-amine
NCGC00346431-01
Neuroprotectant, Novartis
Neuroprotectant, Santhera
Nootropic agent, Novartis
Nootropicagent, Santhera
Omigapil
Omigapil [INN]
Omigapil)
QLMMOGWZCFQAPU-UHFFFAOYSA-N
SCHEMBL333032
SNT-317
TCH-346
TCH-346B
TCH346
Tch 346
UNII-5V14HD0N4Q
ZINC33943510
dibenz[b,f]oxepin-10-ylmethyl-N-methyl-N-prop-2-ynylamine
dibenzo-(b,f)oxepin-10-ylmethyl-methyl-prop-2-ynyl-amine
pubmed:29559585
chebi:CHEBI:35364
chebi:CHEBI:41778
chembl:CHEMBL1232111
chembl:CHEMBL3734823
drugbank:DB12879
inchi:InChI=1S/C19H17NO/c1-3-12-20(2)14-16-13-15-8-4-6-10-18(15)21-19-11-7-5-9-17(16)19/h1,4-11,13H,12,14H2,2H3
pubchem.compound:6419718
smiles:CN(CC#C)CC1=CC2=CC=CC=C2OC3=CC=CC=C31
orcid:0000-0001-9661-5277
A dual inhibitor of PDE5 and HDACs, chronic treatment of Tg2576 mice, a well characterized AD mouse model, showed decreased Ab and Tau phsophorylation and inhibition of GSK3B activity.
CM-414
2-(4-morpholinylmethyl)-2-propenoic acid
2-(Morpholinomethyl)acrylic acid
2-(Morpholinomethyl)propenoic acid
2-(morpholin-4-ylmethyl)prop-2-enoic Acid
2-MORPHOLIN-4-YLMETHYL-ACRYLIC ACID
2-Morpholin4-ylmethyl-acrylic acid
2-[(morpholin-4-yl)methyl]prop-2-enoic acid
2-morpholin-4-ylmethyl-2-propenoic acid
2-morpholin-4ylmethyl-2-propenoic acid
4-Morpholinepropanoicacid, a-methylene-
4432-44-4
4868AH
A826542
AB0085720
AB1552
AJ-96850
AKOS010054622
CM-414
CTK4I8112
DB-070534
DTXSID30439182
F9995-2550
FT-0718529
IGZSSKAOSOCVPH-UHFFFAOYSA-N
K-8942
KB-106928
MCULE-2720405682
MFCD06208438
MolPort-019-997-392
SCHEMBL793684
ZINC38760485
pubmed:27550730
cas:4432-44-4
inchi:InChI=1S/C8H13NO3/c1-7(8(10)11)6-9-2-4-12-5-3-9/h1-6H2,(H,10,11)
pubchem.compound:10397232
smiles:C=C(CN1CCOCC1)C(=O)O
orcid:0000-0001-9661-5277
A structural motif of DAPK (Death-Associated Protein Kinase) positively regulating the kinase activity.
DAPK, basic loop (BL) motif
pubmed:27133022
orcid:0000-0001-9661-5277
One of the five main histone proteins of chromatin structure, acetylation at Lys 9 was positively linked with the transcriptional activation of various genes involved in neuro-regeneration following peripheral axonal injury, among which BDNF.
Histone H3
pubmed:24686445
fplx:Histone_H3
orcid:0000-0001-9661-5277
Inhibitor of GSK3Beta and DYRK1 kinases
ID-8
pubmed:28884684
orcid:0000-0001-9661-5277
A synthetic derviative of 2,4-diaminothiazole serving as an inhibitor of CDK5 kinase acitivty and of tau PHF1 epitope phosphorylation
LDN-193594
(4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(2-fluorophenyl)methanone
1289638-15-8
BDBM50340902
CHEMBL1761791
KB-274259
NSC-747885
NSC747885
XHJMMMPXTUEBMQ-UHFFFAOYSA-N
ZINC71317068
ldn-193594
pubmed:23737518
chembl:CHEMBL1761791
inchi:InChI=1S/C15H11FN4OS/c16-11-6-2-1-5-10(11)12(21)13-14(17)20-15(22-13)19-9-4-3-7-18-8-9/h1-8H,17H2,(H,19,20)
pubchem.compound:54581340
smiles:C1=CC=C(C(=C1)C(=O)C2=C(N=C(S2)NC3=CN=CC=C3)N)F
orcid:0000-0001-9661-5277
A synthetic derviative of 2,4-diaminothiazole with a lesser powerful inhibitory effect on CDK5, but a potent inhibitor of Gsk3b
LDN-193665
pubmed:23737518
cas:1289638-16-9
inchi: InChI=1S/C15H11FN4OS/c16-10-4-1-3-9(7-10)12(21)13-14(17)20-15(22-13)19-11-5-2-6-18-8-11/h1-8H,17H2,(H,19,20)
smiles:FC1=CC=CC(C(C2=C(N)N=C(NC3=CN=CC=C3)S2)=O)=C1
orcid:0000-0001-9661-5277
Small molecule of the diaminothiazole class, acting as inhibitor of CDK5 and GSK3Beta kinases
LDN-213843
pubmed:23737518
inchi:InChI=1S/C19H19FN6OS/c20-14-4-2-1-3-13(14)16(27)17-18(21)25-19(28-17)24-12-5-6-15(23-11-12)26-9-7-22-8-10-26/h1-6,11,22H,7-10,21H2,(H,24,25)
smiles:C1(=CC=CC=C1C(C4=C(N)N=C(NC2=CN=C(C=C2)N3CCNCC3)S4)=O)F
orcid:0000-0001-9661-5277
A gradual weakening of neuronal synaptic connections lasting hours or longer following a long patterned stimulus. Along with LTP (long term potentiation) is one of the main mechanisms of memory formation, more specifically of spatial memory. The mechanism involves an interplay of NMDA and AMPA glutamate receptors, with minimal intracellular calcium levels triggering a cellular cascade leading to the removal of the latter and an overall decrease of the glutammate receptors in the postsynaptic neurons, thus weakening the synapse.
Long-Term Depression
pubmed:22833681
orcid:0000-0001-9661-5277
Pathological spreading pattern of tau into defined anatomycally interconnected brain regions during the progression of tauopathy.
Pathological Tau Spreading
pubmed:29540553
orcid:0000-0001-9661-5277
PrPSc (scrapie isoform of the prion protein) prions are the infectious agent behind diseases such as Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy in cattle, chronic wasting disease in cervids (deer, elk, moose, and reindeer), as well as goat and sheep scrapie. PrPSc is an alternatively folded variant of the cellular prion protein, PrPC, which is a regular, GPI-anchored protein that is present on the cell surface of neurons and other cell types.
PrPSc
pubmed:22692785
pubmed:29414853
uniprot:F7VJQ1
uniprot.isoform:F7VJQ1-1
orcid:0000-0001-9661-5277
A turn-like structure formed in tau as a conseguence of the phosphorylation of only Ser202 and Thr205 residues, protects against aggregation.
Tau Protein Secondary Structure, Turn
pubmed:28784767
orcid:0000-0001-9661-5277
RG7345 is a humanized monoclonal antibody targeting the tau phosphoepitope pS422. Tau phosphorylated at this site is considered a pathological form that has been linked to the relocalization of tau away from microtubules and toward the somato-dendritic compartment of the neuron.
Tau antibody, RG7345
pubmed:26751493
pubmed:10967355
orcid:0000-0001-9661-5277
Selective inhibitor of HDAC3
RGFP966
(2E)-N-(2-amino-4-fluorophenyl)-3-{1-[(2E)-3-phenylprop-2-en-1-yl]-1H-pyrazol-4-yl}prop-2-enamide
(E)-N-(2-amino-4-fluorophenyl)-3-(1-cinnamyl-1H-pyrazol-4-yl)acrylamide
1357389-11-7
1396841-57-8
2-Propenamide, N-(2-amino-4-fluorophenyl)-3-[1-[(2E)-3-phenyl-2-propen-1-yl]-1H-pyrazol-4-yl]-, (2E)-
2686AH
A13218
AK676067
AKOS030526449
BC600495
BCP08102
BLVQHYHDYFTPDV-VCABWLAWSA-N
C21H19FN4O
CHEBI:131163
CHEMBL4078477
D00HXX
DA-45384
DA-45706
EX-A229
GTPL7500
J-007305
KB-148638
MFCD26960954
MolPort-035-395-807
QC-11774
RGFP 966
RGFP-966
RGFP966
RGFP966 Racemate
RGFP966, >=98% (HPLC)
SB19284
SCHEMBL12497867
SCHEMBL12497871
SW219401-1
ZINC95616594
s7229
pubmed:28771976
chebi:CHEBI:131163
inchi:InChI=1S/C21H19FN4O/c22-18-9-10-20(19(23)13-18)25-21(27)11-8-17-14-24-26(15-17)12-4-7-16-5-2-1-3-6-16/h1-11,13-15H,12,23H2,(H,25,27)/b7-4+,11-8+
pubchem.compound:56650312
smiles:C1=CC=C(C=C1)C=CCN2C=C(C=N2)C=CC(=O)NC3=C(C=C(C=C3)F)N
orcid:0000-0001-9661-5277
Inhibitor of MAP2K1/2 kinases activity in murine neuroblastoma cell line N2A
SL-327
(2Z)-3-amino-3-[(4-aminophenyl)sulfanyl]-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile
(Z)-3-amino-3-(4-aminophenylthio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile
3-amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile
3-amino-3-[(4-aminophenyl)sulfanyl]-2-[2-(trifluoromethyl)phenyl]acrylonitrile
3-amino-3-[(4-aminophenyl)thio]-2-[2-(trifluoromethyl)phenyl]-2-propenenitrile
305350-87-2
AKOS024456884
AOB5954
BC600460
BCP05310
BRD-K12244279-001-01-7
Benzeneacetonitrile, alpha-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)-
CCG-206867
CHEBI:92211
CS-0910
D04WPA
DTXSID90429549
E/Z-a-[amino[(4-aminophenyl)thio]methylen]-2-(trifluoromethyl)benzeneacetonitrile
EC-000.2354
EX-A1069
GTPL6008
HMS3229K18
HMS3678M21
HSCI1_000044
HY-15437
J-018001
JLOXTZFYJNCPIS-FYWRMAATSA-N
K00090
KB-80585
LS-193345
MEK1/2 Inhibitor
MFCD06411432
MolPort-006-069-021
NCGC00092290-01
NCGC00092290-02
SB19419
SCHEMBL570317
SCHEMBL570318
SL 327
SL-327
SL327
SL327, >=98% (HPLC), Mixture of E & Z isomers, solid
SW219839-1
W-5333
X3440
Z-& E-a-(Amino-((4-aminophenyl)thio)methylene)-2-(trifluoromethyl)benzeneacetonitrile
Z-& E-alpha-(Amino-((4-aminophenyl)thio)methylene)-2-(trifluoromethyl)benzeneacetonitrile
ZINC1910234
alpha-[Amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile
alpha-{amino[(4-aminophenyl)thio]methylene}-2-(trifluoromethyl)benzeneacetonitrile
s1066
pubmed:24401760
cas:305350-87-2
chebi:CHEBI:92211
inchi:InChI=1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+
pubchem.compound:9549284
smiles:C1=CC=C(C(=C1)C(=C(N)SC2=CC=C(C=C2)N)C#N)C(F)(F)F
orcid:0000-0001-9661-5277
Spinocerebellar ataxia type 11 (SCA11) is characterized by progressive cerebellar ataxia and abnormal eye signs (jerky pursuit, horizontal and vertical nystagmus). Caused by mutations in the TTBK2 (Tau Tubulin Kinase 2) gene, is inherited in an autosomal dominant manner.
Spinocerebellar Ataxia 11
pubmed:21548880
orcid:0000-0001-9661-5277
A thiol derivative, pan-HDAC inhibitor
ST7612AA1
1428535-92-5
A14418
BDBM50027652
CHEMBL3353926
SB17083
SCHEMBL14812001
ST-7612AA1
Thioacetic acid S-[(S)-6-[[(R)-5-oxopyrrolidine-2-ylcarbonyl]amino]-6-(phenylcarbamoyl)hexyl] ester
pubmed:27917100
chembl:CHEMBL3353926
inchi:InChI=1S/C20H27N3O4S/c1-14(24)28-13-7-3-6-10-16(19(26)21-15-8-4-2-5-9-15)23-20(27)17-11-12-18(25)22-17/h2,4-5,8-9,16-17H,3,6-7,10-13H2,1H3,(H,21,26)(H,22,25)(H,23,27)/t16-,17+/m0/s1
pubchem.compound:71538210
smiles:CC(=O)SCCCCC[C@H](NC(=O)[C@H]1CCC(=O)N1)C(=O)Nc2ccccc2
orcid:0000-0001-9661-5277
Rabbit polyclonal antibody against tau pSer262, AstraZeneca
Tau antibody, AGG5759
pubmed:23666762
orcid:0000-0001-9661-5277
Tau epitope consisting of pThr396 and pSer404
Tau epitope, AD2
pubmed:11943212
orcid:0000-0001-9661-5277
Tau epitope consisting of pSer422
Tau epitope, AP422
pubmed:11943212
orcid:0000-0001-9661-5277
Tau epitope consisting of pSer214 and pThr212
Tau epitope, AT100
pubmed:22833681
orcid:0000-0001-9661-5277
Tau epitope consisting of pThr181
Tau epitope, AT270
pubmed:11943212
orcid:0000-0001-9661-5277
Inhibitor of O-GlcNAcase (OGA)
Thiamet G
(3aR)-2-(Ethylamino)-6beta,7alpha-dihydroxy-3aalpha,6,7,7aalpha-tetrahydro-5H-pyrano[3,2-d]thiazole-5alpha-methanol
(3aR,5R,6S,7R,7aR)-2-(Ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol
(3aR,5R,6S,7R,7aR)-2-(ethylamino)-5-(hydroxymethyl)-3a,6,7,7a-tetrahydro-5H-pyrano[3,2-d]thiazole-6,7-diol
(3aR,5R,6S,7R,7aR)-2-(ethylamino)-5-(hydroxymethyl)-3aH,5H,6H,7H,7aH-pyrano[3,2-d][1,3]thiazole-6,7-diol
1,2-Dideoxy-2'-ethylamino-a-D-glucopyranoso-[2,1-d]-2'-thiazoline
1009816-48-1
2070AH
2754AH
5H-Pyrano[3,2-d]thiazole-6,7-diol, 2-(ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-, (3aR,5R,6S,7R,7aR)-
ACN-038039
AKOS024458135
AOB5913
C9H16N2O4S
EX-A2240
HMS3648I18
HY-12588
J-000295
MFCD15144964
NCGC00344096-03
SR-01000946377
SR-01000946377-1
SW219118-1
Thiamet G
Thiamet G, >=98% (HPLC)
Thiamet G;\n2-(ethylamino)-3aR,6S,7R,7aR-tetrahydro-5R-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol
Thiamet-G
W-200641
ZINC16052637
s7213
pubmed:22833681
chembl:CHEMBL1213603
inchi:InChI=1S/C9H16N2O4S/c1-2-10-9-11-5-7(14)6(13)4(3-12)15-8(5)16-9/h4-8,12-14H,2-3H2,1H3,(H,10,11)/t4-,5-,6-,7-,8-/m1/s1
pubchem.compound:24808478
smiles:CCNC1=NC2C(C(C(OC2S1)CO)O)O
orcid:0000-0001-9661-5277
Dye binding to PHF used in AD diagnostics
Thioflavin S
pubmed:7667312
orcid:0000-0001-9661-5277
Chemical compound group of susbtrate competitive selective HDAC6 inhibitors
Trithiocarbonates
pubmed:18558669
orcid:0000-0001-9661-5277
Inhibitor of HDAC6
Tubacin
pubmed:23487739
cas:537049-40-4
chebi:CHEBI:94166
inchi:InChI=1S/C41H43N3O7S/c45-26-28-17-19-29(20-18-28)35-25-34(27-52-41-43-38(30-11-5-3-6-12-30)39(51-41)31-13-7-4-8-14-31)49-40(50-35)32-21-23-33(24-22-32)42-36(46)15-9-1-2-10-16-37(47)44-48/h3-8,11-14,17-24,34-35,40,45,48H,1-2,9-10,15-16,25-27H2,(H,42,4
iupac:N1-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N8-hydroxy-octanediamide
smiles:O=C(CCCCCCC(NO)=O)NC(C=C1)=CC=C1[C@@H]2O[C@H](C3=CC=C(CO)C=C3)C[C@H](CSC4=NC(C5=CC=CC=C5)=C(C6=CC=CC=C6)O4)O2
orcid:0000-0001-9661-5277
Inhibitor of HDAC6 shown to also decrease tau hyperphosphorylation and Ab load
Tubastatin A
pubmed:24844691
cas:1252003-15-8
chebi:CHEBI:94186
inchi:InChI=1S/C20H21N3O2/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25/h2-9,25H,10-13H2,1H3,(H,21,24)
smiles:ONC(C1=CC=C(CN2C(CCN(C)C3)=C3C4=C2C=CC=C4)C=C1)=O
orcid:0000-0001-9661-5277
Inhibitory oligopeptide of the USP14, a deubiquitinating enzyme.
USP14 Aptamer
pubmed:26041011
orcid:0000-0001-9661-5277
A neuron that uses acetylcholine as a vesicular neurotransmitter.
cholinergic neuron
pubmed:29221819
mesh:D059329
orcid:0000-0001-9661-5277
The thin layer of gray matter on the surface of the cerebral hemisphere that develops from the telencephalon. It consists of the neocortex (6 layered cortex or isocortex), the hippocampal formation and the olfactory cortex.
cerebral cortex
pubmed:29221819
mesh:D002540
orcid:0000-0001-9661-5277
Inhibitor of HDAC6
crebinostat
pubmed:25546293
cas:1092061-61-4
inchi:InChI=1S/C20H23N3O3/c24-19(9-5-2-6-10-20(25)23-26)22-21-15-16-11-13-18(14-12-16)17-7-3-1-4-8-17/h1,3-4,7-8,11-15,26H,2,5-6,9-10H2,(H,22,24)(H,23,25)/b21-15+
smiles:C1=CC=CC(=C1)C2=CC=C(C=C2)C=NNC(CCCCCC(=O)NO)=O
orcid:0000-0001-9661-5277
Compound class with kinase inhibition properties, specifically for CDK5 and GSK3Beta
diaminothiazole
pubmed:23737518
orcid:0000-0001-9661-5277
Layer of the entorhinal cortex lying superficial to layer 3 and deep to layer 1. It is characterized by medium-to large sized stellate cells that are grouped into prominent clusters, particularly in the rostral entorhinal cortex.
entorhinal cortex layer 2
pubmed:27798139
orcid:0000-0001-9661-5277
The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.
granular layer of cerebellar cortex
pubmed:29221819
orcid:0000-0001-9661-5277
A powerful inhibitor of GSK3B
indirubin
pubmed:11013232
cas:479-41-4
chemspider:4477010
inchi:nChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-
smiles:c1ccc2c(c1)/C(=C/3\C(=O)c4ccccc4N3)/C(=O)N2
orcid:0000-0001-9661-5277
Inhibitor of tau aggregation
isocarboxazide
1-Benzyl-2-(5-methyl-3-isoxazolyl-carbonyl)hydrazine
1-Benzyl-2-(5-methyl-3-isoxazolylcarbonyl)hydrazine
3-(2-BENZYLHYDRAZOCARBOXY)-5-METHYL-ISOXAZOLE
3-Isoxazolecarboxylic acid, 2-(phenylmethyl)hydrazide
3-Isoxazolecarboxylic acid, 2-benzylhydrazide
3-Isoxazolecarboxylic acid, 5-methyl-, 2-(phenylmethyl)hydrazide
3-Isoxazolecarboxylic acid, 5-methyl-, 2-benzylhydrazide
34237V843T
4-27-00-03999 (Beilstein Handbook Reference)
5-Methyl-3-isoxazolecarboxylic acid 2-benzylhydrazide
5-methyl-N'-(phenylmethyl)-3-isoxazolecarbohydrazide
5-methyl-N'-(phenylmethyl)isoxazole-3-carbohydrazide
59-63-2
AB00513923
AC-24841
AC1L1GNE
AJ-08053
AKOS016003091
ANW-58213
API0000611
AX8135097
BC645218
BDBM163692
BMIH
BPBio1_001024
BRD-K93332168-001-03-2
BRN 0201295
BSPBio_000930
Benazide
CAS-59-63-2
CCG-220795
CCRIS 9178
CHEBI:93635
CHEMBL1201168
CS-0008613
CTK8B7692
D02580
D0I2VK
DB01247
DSSTox_CID_3171
DSSTox_GSID_23171
DSSTox_RID_76902
DTXSID4023171
EINECS 200-438-4
Enerzer
FCH2716017
FT-0670438
GTPL7204
HMS1570O12
HMS2097O12
HMS2230E11
HMS3369G18
HMS3714O12
HY-13929
ISOCARBOXAZID (200 MG)
Isocarbonazid
Isocarbossazide
Isocarbossazide [DCIT]
Isocarboxazid (ICD)
Isocarboxazid (INN)
Isocarboxazid 5-methyl-3-isoxazole-carboxylic acid 2-benzylhydrazide, AldrichCPR
Isocarboxazid [INN:BAN]
Isocarboxazid [USP:INN:BAN]
Isocarboxazida
Isocarboxazida [INN-Spanish]
Isocarboxazide
Isocarboxazide [INN-French]
Isocarboxazidum
Isocarboxazidum [INN-Latin]
Isocarboxizid
Isocarboxyzid
KB-258619
LS-86607
MLS002154005
MLS003106729
Maraplan
Marplan
Marplan (TN)
Marplon
N'-Benzyl N-methyl-5-isoxazolecarboxylhydrazide-3
N'-Benzyl-5-methyl-3-isoxazolecarbohydrazide #
N'-Benzyl-5-methylisoxazole-3-carbohydrazide
N'-benzyl-5-methyl-1,2-oxazole-3-carbohydrazide
NCGC00016267-01
NCGC00016267-02
NCGC00016267-03
NSC 169893
NSC-169893
NSC169893
Prestwick0_000795
Prestwick1_000795
Prestwick2_000795
Prestwick3_000795
Ro 5-0831
Ro 5-0831/1
Ro5-0831
SCHEMBL49562
SMR001233334
SPBio_002869
SR-01000841192
SR-01000841192-2
SR-01000841192-3
TC-146958
Tox21_110336
UNII-34237V843T
WLN: T5NOJ C1 EVMM1R
XKFPYPQQHFEXRZ-UHFFFAOYSA-N
Y0484
ZINC1587
isocarboxazid
pubmed:26751493
chebi:CHEBI:93635
chembl:CHEMBL1201168
drugbank:DB01247
inchi:InChI=1S/C12H13N3O2/c1-9-7-11(15-17-9)12(16)14-13-8-10-5-3-2-4-6-10/h2-7,13H,8H2,1H3,(H,14,16)
pubchem.compound:3759
smiles:CC1=CC(=NO1)C(=O)NNCC1=CC=CC=C1
orcid:0000-0001-9661-5277
Inhibitor of CKD5 activity
isopentanyladenine
(3-methyl-but-2-enyl)-(7(9)H-purin-6-yl)-amine
(3-methylbut-2-enyl)purin-6-ylamine
13255-47-5
1H-Purin-6-amine, N-(3-methyl-2-butenyl)-
1H-Purin-6-amine, N-(3-methyl-2-butenyl)- (9CI)
2365-40-4
2exm
3-methylbut-2-enyl(7H-purin-6-yl)amine
365I404
5122-37-2
6-((3-Methyl-2-butenyl)amino)purine
6-(.gamma.,.gamma.-Dimethylallylamino)purine
6-(3,3-DIMETHYLALLYLAMINO)PURINE
6-(3-methyl-2-buten-1-ylamino)purine
6-(gamma,gamma-DIMETHYLALLYLAMINO) PURINE
6-(gamma,gamma-Dimethylallylamino)purine
6-(gamma,gamma-Dimethylallylamino)purine, BioReagent, plant cell culture tested, 1 mg/mL
6-(gamma,gamma-Dimethylallylamino)purine, BioReagent, plant cell culture tested, >=90%
6-(gamma,gamma-Dimethylallylamino)purine, BioReagent, plant cell culture tested, >=98.5%
6-(gamma,gamma-Dimethylallylamino)purine, Vetec(TM) reagent grade, >=98.5%
6-(|A,|A-Dimethylallylamino)purine
6-[(3-Methyl-2-butenyl)amino]purine
6-[(3-methylbut-2-en-1-yl)amino]purine
A816825
AC-15608
AC1L3NL1
ACM2365404
AK163607
AKOS005257639
AKOS015914857
AKOS028109417
AN-50750
AS-17517
AX8017021
Adenine, N-(3-methyl-2-butenyl)-
Adenine, N-(3-methyl-2-butenyl)- (8CI)
BC209320
BID525
BRD-K62158429-001-01-7
C04083
CCG-38046
CHEBI:17660
CHEMBL476189
CI-027
CS-0043352
CTK8G1492
D-4760
D0I1SZ
DB08768
DTXSID10178325
Dimethylallyladenine
EBD28940
Enadenine
FT-0629731
HMS1543F03
HY-112103
HYVABZIGRDEKCD-UHFFFAOYSA-N
I14-7114
IPADE
Isopentenyl adenine
Isopentenyladenine
KB-57456
LS-184209
MCULE-6781114249
MFCD00132998
MolPort-002-511-573
N(6)-(.DELTA.2-Isopentenyl)aminopurine
N(6)-(Delta2-isopentenyl)adenine
N(6)-(delta(2)-Isopentenyl)adenine
N(6)-dimethylallyladenine
N-(.DELTA.2-Isopentenyl)adenine
N-(.gamma.,.gamma.-Dimethylallyl)adenine
N-(3-METHYLBUT-2-EN-1-YL)-9H-PURIN-6-AMINE
N-(3-Methyl-2-butenyl)-1H-purin-6-amine
N-(3-Methyl-2-butenyl)-1H-purin-6-amine #
N-(3-Methyl-2-butenyl)adenine
N-(3-methyl-2-butenyl)-9H-purin-6-amine
N-(3-methylbut-2-en-1-yl)-7H-purin-6-amine
N-(3-methylbut-2-enyl)-7H-purin-6-amine
N-(3-methylbut-2-enyl)-9H-purin-6-amine
N-(delta2-Isopentenyl)adenine
N-(gamma,gamma-Dimethylallyl)adenine
N-6-(3,3-Dimethylallyl)adenine
N-6-(delta2-Isopentenyl)-adenine
N6 -(Delta2 -Isopentenyl)adenine
N6-(.DELTA.2-Isopentenyl)adenine
N6-(.DELTA.2-Isopentenyl)aminopurine
N6-(2-Isopentenyl)-adenine
N6-(2-Isopentenyl)adenine
N6-(3-Methyl-2-butenyl)adenine
N6-(3-Methylbut-2-enyl)adenine
N6-(delta 2-Isopentenyl)-adenine
N6-(delta2-Isopentenyl)-adenine
N6-(delta2-Isopentenyl)adenine
N6-(delta2-Isopentenyl)aminopurine
N6-.DELTA.2-Isopentenyl)adenine
N6-Delta2-isopentenyladenine
N6-Dimethylallyladenine
N6-Isopentenyladenine
NCGC00014084
NCGC00014084-02
NCGC00097193-01
NCI106958
NCI60_000165
NCIStruc1_000935
NCIStruc2_000921
NSC 106958
NSC-106958
NSC106958
Oprea1_344117
SC-18768
SCHEMBL459276
ST044513
ST24048354
TimTec1_003281
UNII-V500BB256Z
V0538
V500BB256Z
ZB000921
ZINC32351
ZX-AFC000343
isopentenyl-adenine
n-isopentenyladenine
pubmed:8726973
chebi:CHEBI:17660
drugbank:DB08768
inchi:InChI=1S/C10H13N5/c1-7(2)3-4-11-9-8-10(13-5-12-8)15-6-14-9/h3,5-6H,4H2,1-2H3,(H2,11,12,13,14,15)
pubchem.compound:92180
smiles:CC(=CCNC1=NC=NC2=C1NC=N2)C
orcid:0000-0001-9661-5277
Increases intracellular calcium levels, and induces the association of TGM2 with tau, positively affecting the activity of the former
maitotoxin
9P59GES78D
CHEMBL2152261
HSDB 7753
Maitotoxin
Maitotoxin 1
UNII-9P59GES78D
pubmed:10537045
cas:59392-53-9
chembl:ChEMBL2152261
chemspider:25991548
inchi:InChI=1S/C164H258O68S2.2Na/c1-24-26-65(2)68(5)41-74(168)117(179)85-33-36-152(11)106(203-85)55-109-162(21,231-152)64-161(20)105(210-109)51-89-83(220-161)28-25-27-82-99(199-89)59-157(16)108(202-82)56-107-153(12,230-157)39-38-151(10)112(211-107)61-158(17)111(224-151)54-101(176)163(22,232-158)103-32-31-84-90(204-103)53-110-156(15,219-84)62-113-150(9,223-110)37-34-102-155(14,225-113)63-114-164(23,227-102)147(192)149-159(18,226-114)58-81(175)134(218-149)133-79(173)47-93-136(216-133)120(182)119(181)92(200-93)44-72(166)43-76(170)131-77(171)46-94-137(214-131)122(184)124(186)143(207-94)145-126(188)125(187)144-146(217-145)128(190)139-97(208-144)50-88-87(206-139)49-96-138(205-88)127(189)141(229-234(196,197)198)95(201-96)45-75(169)118(180)132-78(172)48-98-140(215-132)129(191)148-160(19,221-98)60-100-91(209-148)52-104-154(13,222-100)57-80(174)135-142(212-104)123(185)121(183)130(213-135)71(8)115(177)67(4)29-30-86(228-233(193,194)195)116(178)69(6)42-73(167)70(7)66(3)35-40-165;;/h24-25,28,35,65,67-69,71-149,165-192H,1,7,26-27,29-34,36-64H2,2-6,8-23H3,(H,193,194,195)(H,196,197,198);;/q;2*+1/p-2/b28-25-,66-35+;;/t65-,67+,68+,69+,71+,72+,73+,74+,75-,76+,77+,78+,79+,80+,81+,82+,83-,84+,85-,86-,87-,88+,89+,90-,91-,92-,93-,94-,95-,96+,97-,98+,99-,100+,101+,102+,103-,104+,105-,106-,107+,108-,109+,110+,111-,112-,113+,114+,115+,116+,117-,118+,119-,120+,121+,122+,123-,124+,125+,126+,127+,128+,129-,130-,131-,132-,133+,134+,135+,136+,137+,138+,139-,140+,141-,142-,143+,144-,145+,146+,147-,148+,149+,150-,151+,152+,153-,154-,155-,156-,157+,158+,159-,160-,161+,162-,163+,164+;;/m0../s1
pubchem.compound:71460273
smiles:C[C@H](CC[C@@H]([C@@H]([C@H](C)C[C@H](C(=C)/C(=C/CO)/C)O)O)OS(=O)(=O)[O-])[C@H]([C@@H](C)[C@H]1[C@@H]([C@@H]([C@H]2[C@H](O1)[C@@H](C[C@]3([C@H](O2)C[C@H]4[C@H](O3)C[C@]5([C@H](O4)[C@H]([C@H]6[C@H](O5)C[C@H]([C@H](O6)[C@@H]([C@H](C[C@H]7[C@@H]([C@@H]([C@H]8[C@H](O7)C[C@H]9[C@H](O8)C[C@H]1[C@H](O9)[C@H]([C@@H]2[C@@H](O1)[C@@H]([C@H]([C@@H](O2)[C@H]1[C@@H]([C@H]([C@H]2[C@@H](O1)C[C@H]([C@@H](O2)[C@@H](C[C@H](C[C@H]1[C@@H]([C@H]([C@H]2[C@@H](O1)C[C@H]([C@@H](O2)[C@H]1[C@@H](C[C@]2([C@H](O1)[C@@H]([C@]1([C@H](O2)C[C@]2([C@H](O1)CC[C@]1([C@H](O2)C[C@]2([C@H](O1)C[C@H]1[C@H](O2)CC[C@H](O1)[C@]1([C@@H](C[C@H]2[C@](O1)(C[C@H]1[C@](O2)(CC[C@]2([C@H](O1)C[C@H]1[C@](O2)(C[C@H]2[C@H](O1)C/C=C\[C@H]1[C@H](O2)C[C@H]2[C@](O1)(C[C@]1([C@H](O2)C[C@H]2[C@](O1)(CC[C@H](O2)[C@H]([C@@H](C[C@@H](C)[C@@H](C)CC=C)O)O)C)C)C)C)C)C)C)O)C)C)C)C)C)O)C)O)O)O)O)O)O)O)O)O)O)O)O)O)OS(=O)(=O)[O-])O)O)O)O)C)C)O)O)O)O.[Na+].[Na+]
orcid:0000-0001-9661-5277
Inhibitor of CKD5 activity
olomoucine
101622-51-9
1966AH
1w0x
2,6,9-Trisubstituted purine deriv. 26
2-(2-Hydroxyethylamino)-6-(benzylamino)-9-methylpurine
2-(2-Hydroxyethylamino)-6-benzylamino-9-isopropylpurine
2-(2-Hydroxyethylamino)-6-benzylamino-9-methylpurine
2-(6-(benzylamino)-9-methyl-9H-purin-2-ylamino)ethanol
2-(Hydroxyethylamino)-6-benzylamino-9-methylpurine
2-({9-methyl-6-[benzylamino]purin-2-yl}amino)ethan-1-ol
2-[[6-(benzylamino)-9-methyl-purin-2-yl]amino]ethanol
2-[[6-(benzylamino)-9-methylpurin-2-yl]amino]ethanol
2-[[9-Methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-ethanol
2-[[9-Methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]ethanol
2-[[9-Methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]ethanol, 9CI
2-[[9-methyl-6-(phenylmethylamino)purin-2-yl]amino]ethanol
2-{[6-(benzylamino)-9-methyl-9H-purin-2-yl]amino}ethan-1-ol
2-{[6-(benzylamino)-9-methyl-9h-purin-2-yl]amino}ethanol
4erk
6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine
6-(benzylamino)-2-[(2-hydroxyethyl)amino]-9-methylpurine
6-Benylamino-2-(2-hydroxyethylamino)-9-methylpurine
6-Benzylamino-2-(2-hydroxyethylamino)-9-methylpurine
6-benzylamino-2-[2-hydroxyethylamino]-9-methylpurine
6A839B2HYS
AC1L1IID
AC1Q4XZU
ACMC-20cp0o
AKOS005145988
BCBcMAP01_000205
BDBM5718
BIO3107
BMK1-E10
BRD-K82731415-001-03-9
BRD-K82731415-001-04-7
BSPBio_000990
Bio1_000336
Bio1_000825
Bio1_001314
Bio2_000335
Bio2_000815
BiomolKI2_000052
BiomolKI_000046
C-28477
C15H18N6O
CBiol_002050
CCG-100650
CHEMBL280074
CJ-26517
CTK4A0020
D00BPA
DB02116
DTXSID90144068
EU-0100883
Ethanol, 2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-
Ethanol,2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-
FT-0642456
GTVPOLSIJWJJNY-UHFFFAOYSA-N
HMS1362B11
HMS1792B11
HMS1990B11
HMS3262B08
HMS3267L09
HMS3403B11
HMS3650F19
HMS3676E10
IDI1_002090
IN1179
IN1182
InSolution™ Olomoucine
J-000453
KB-162429
KBio2_000330
KBio2_002898
KBio2_005466
KBio3_000659
KBio3_000660
KBioGR_000330
KBioSS_000330
Kinome_2870
LP00883
Lopac-O-0886
Lopac0_000883
MFCD00189360
MolPort-003-849-700
NCGC00015763-01
NCGC00015763-02
NCGC00015763-03
NCGC00015763-04
NCGC00015763-05
NCGC00015763-06
NCGC00015763-07
NCGC00015763-08
NCGC00015763-09
NCGC00025096-01
NCGC00025096-02
NCGC00025096-03
NCGC00025096-04
NCGC00025096-05
NCGC00025096-06
NCGC00025096-07
NCGC00261568-01
NCI60_022916
NSC 666096
NSC-666096
NSC666096
O 0886
OLO
Olomoucine, >=98% (HPLC)
Olomucine
RT-014854
SCHEMBL135056
SMP1_000281
SR-01000075518
SR-01000075518-1
SR-01000075518-3
SR-01000075518-6
ST50298830
TRA0035611
Tocris-1284
Tox21_500883
UNII-6A839B2HYS
UPCMLD-DP136
UPCMLD-DP136:001
UPCMLD-DP136:002
ZINC1641925
ZX-AFC001655
olomoucine
purine deriv. 5
pubmed:8726973
chebi:CHEBI:44661
drugbank:DB02116
inchi:InChI=1S/C15H18N6O/c1-21-10-18-12-13(17-9-11-5-3-2-4-6-11)19-15(16-7-8-22)20-14(12)21/h2-6,10,22H,7-9H2,1H3,(H2,16,17,19,20)
pubchem.compound:4592
smiles:CN1C=NC2=C1N=C(NCCO)N=C2NCC1=CC=CC=C1
orcid:0000-0001-9661-5277
Inhibitor of tau aggregation
oxazolidinedione
1,3-oxazolidin-2,4-dione
1,3-oxazolidine-2,4-dione
12770-97-7
153301-EP2281822A1
1572AB
2,4-Oxazolidenedione
2,4-Oxazolidinedione
2,4oxazolidinedione
2346-26-1
346O261
A816734
AC1L3YF0
AJ-30743
AK-80133
AKOS002529400
AN-50728
ANW-57979
CJ-28984
CMLDBU00003511
COWNFYYYZFRNOY-UHFFFAOYSA-N
CTK0H9315
DA-18172
DS-15871
F2167-1227
FT-0704394
KB-67472
KS-00000MOC
MFCD02691902
MolPort-018-280-326
NSC 120350
NSC-120350
NSC120350
OXAZOLIDINE-2,4-DIONE
Oxazolidinedione
R22D15229R
SC-49693
SCHEMBL123971
SCHEMBL1395587
SCHEMBL8159833
TC-146724
UNII-R22D15229R
Z56762271
ZINC1709820
hydroxyoxazolinone
pubmed:26751493
inchi:InChI=1S/C3H3NO3/c5-2-1-7-3(6)4-2/h1H2,(H,4,5,6)
pubchem.compound:97389
smiles:C1C(=O)NC(=O)O1
orcid:0000-0001-9661-5277
Inhibitor of tau aggregation
sudoxicam
(3E)-3-[hydroxy-(1,3-thiazol-2-ylamino)methylidene]-2-methyl-1,1-dioxo-1
(3Z)-3-[hydroxy-(1,3-thiazol-2-ylamino)methylidene]-2-methyl-1,1-dioxo-1
2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-thiazolyl-, 1,1-dioxide
3-[hydroxy-(1,3-thiazol-2-ylamino)methylidene]-2-methyl-1,1-dioxo-1
34042-85-8
4-Hydroxy-2-methyl-N-(1,3-thiazol-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
4-Hydroxy-2-methyl-N-1,3-thiazol-2-yl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
4-hydroxy-2-methyl-1,1-dioxo-N-thiazol-2-yl-1$l^{6},2-benzothiazine-3-carboxamide
4-hydroxy-2-methyl-N-(2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide
AC1L1W79
AC1NSEW2
AC1NSM46
ACM34042858
AKOS030239604
BRN 0628704
CHEMBL20634
CP 15973
CP-15,973
CP-15973
CTK8G3246
D05937
DTXSID50187653
EINECS 251-808-7
FT-0674694
J-019435
LS-40541
MLS006010801
N-(2-Thiazolyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-Dioxide
NSC 615046
NSC-615046
NSC615046
Oprea1_704902
SCHEMBL35067
SCHEMBL35068
SMR004701482
SUDOXICAM
SYCHUQUJURZQMO-UHFFFAOYSA-N
Sudoxicam (USAN/INN)
Sudoxicam [USAN:BAN:INN]
Sudoxicam [USAN:INN:BAN]
Sudoxicamum
Sudoxicamum [INN-Latin]
UNII-X033PDI962
X033PDI962
ZINC5699183
pubmed:26751493
cas:34042-85-8
inchi:InChI=1S/C13H11N3O4S2/c1-16-10(12(18)15-13-14-6-7-21-13)11(17)8-4-2-3-5-9(8)22(16,19)20/h2-7,17H,1H3,(H,14,15,18)
pubchem.compound:54682951
smiles:CN1C(=C(C2=CC=CC=C2S1(=O)=O)O)C(=O)NC3=NC=CS3
orcid:0000-0001-9661-5277
Inhibitor of tau aggregation
thiohydantoin
pubmed:26751493
chembl:CHEMBL1958109
chemspider:1069421
inchi:InChI=1S/C3H4N2OS/c6-2-1-4-3(7)5-2/h1H2,(H2,4,5,6,7)
smiles:O=C1CNC(=S)N1
orcid:0000-0001-9661-5277
Inhibitor of tau aggregation
thioxooxazolidine
pubmed:26751493
orcid:0000-0001-9661-5277
Irreversibly inhibits GSK3B activity
tideglusib
1,2,4-Thiadiazolidine-3,5-dione, 2-(1-naphthalenyl)-4-(phenylmethyl)-
4-Benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione
4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione
4-benzyl-2-(naphthalen-1-yl)-(1,2,4)thiadiazolidine-3,5-dione
4-benzyl-2-naphthalen-1-yl-1,2,4-thiadiazolidine-3,5-dione
4CA-1249
865854-05-3
AK176015
AKOS025149085
AOB5562
BC600768
BCP06016
BDBM50166940
C19H14N2O2S
CHEMBL3545157
CS-0613
D0UT7X
DA-41071
DB12129
DTXSID90235682
EX-A600
FT-0700382
GTPL6929
HY-14872
J-514478
KB-81154
MFCD18633296
MolPort-028-599-952
NP 031112
NP-031112
NP-031112|||4-Benzyl-2-naphthalen-1-yl-1,2,4-thiadiazolidine-3,5-dione
NP-12
NP031112
Q747Y6TT42
RL05359
SB19268
SCHEMBL676929
Tideglusib
Tideglusib (NP031112, NP-12)
Tideglusib [INN]
Tideglusib(NP-031112)
Tideglusib, >=98% (HPLC)
Tideglusib,CAS:865854-05-3
UNII-Q747Y6TT42
W-5777
X5395
ZINC13985228
s2823
pubmed:22102280
inchi:InChI=1S/C19H14N2O2S/c22-18-20(13-14-7-2-1-3-8-14)19(23)24-21(18)17-12-6-10-15-9-4-5-11-16(15)17/h1-12H,13H2
pubchem.compound:11313622
smiles:O=C3SN(c1cccc2c1cccc2)C(=O)N3Cc4ccccc4
orcid:0000-0001-9661-5277
human monoclonal antibody that targets tau epitope 125-131
Tau antibody, 6C5
pubmed:28408124
orcid:0000-0002-3034-9970
mouse monoclonal antibody that targets tau epitope 159-163
Tau antibody, HT7
pubmed:28408124
orcid:0000-0002-3034-9970
During synthesis the HS chains are selectively sulfated at the N, 6-O, and 3-O positions of the glucosamine (GlcNS) and at the 2-O position of the uronic acid residue by HS sulfotransferases and modified by C5-epimerization of glucuronic acid (GlcA) to iduronic acid (IdoA)
6-O-sulfated heparin
pubmed:24878958
orcid:0000-0002-6117-4413
During synthesis the HS chains are selectively sulfated at the N, 6-O, and 3-O positions of the glucosamine (GlcNS) and at the 2-O position of the uronic acid residue by HS sulfotransferases and modified by C5-epimerization of glucuronic acid (GlcA) to iduronic acid (IdoA)
2-O-sulfated heparin
pubmed:24878958
orcid:0000-0002-6117-4413
To make sonicated fibril samples, fibrillized protein was sonicated using a MiSonix Sonicator 4000 (QSonica, LLC) at 50% amplitude for 60 1 s pulses
sonicated tau fibrils
pubmed:29686391
orcid:0000-0002-6117-4413
human monoclonal antibody that targets tau epitope 195-212 (pS202 and pT205)
Tau antibody, 40E8
pubmed:28408124
orcid:0000-0002-3034-9970
rabbit polyclonal antibody that targets tau pS396
Tau antibody, pS396
pubmed:28408124
orcid:0000-0002-3034-9970
human monoclonal antibody that targets tau epitope 385-395
Tau antibody, 4E4
pubmed:28408124
orcid:0000-0002-3034-9970
mouse monoclonal antibody that targets tau epitope 404-441
Tau antibody, Tau46
pubmed:28408124
orcid:0000-0002-3034-9970
The cis conformation of phosphorylated tau is considered to be the main pathogenic tau agent associated with AD neurological impairments. PIN1, a peptidyl-prolyl-cis-transe isomerase, catalizes the rotation of the peptidic bond directly before proline residues inducing a conversion toward the trans conformation, therefore reducing the presence of the pathogenic cis tau isomers.
cis p-tau
pubmed:23157676
pubmed:25628064
orcid:0000-0001-9661-5277
MPT0G211 is a novel potent, selective HDAC6 inhibitor with IC50 of 0.291 nM, displays >1,000-fold selectivity over other HDAC isoforms; significantly inhibits tau phosphorylation on Ser396, Ser404, and phosphorylated tau (p-tau) aggregation, significantly attenuates apoptosis induced by p-tau, inhibits HDAC6/Hsp90 binding and causes subsequent proteasomal degradation of polyubiquitinated proteins; ameliorates learning and memory impairment in animal models of Alzheimer's disease, reduces the amount of phosphorylated tau in the hippocampal CA1 region; also demonstrates antiproliferative activity against human multiple myeloma RPMI 8226, U266, and NCI-H929 cells with no effect on normal bone marrow cells.
MPT0G211
pubmed:29844403
cas:2151853-97-1
inchi:InChI=1S/C17H15N3O2/c21-17(20-22)14-8-6-12(7-9-14)11-19-15-5-1-3-13-4-2-10-18-16(13)15/h1-10,19,22H,11H2,(H,20,21)
smiles:C1=CC(=CC=C1CNC2=CC=CC3=C2N=CC=C3)C(=O)NC
orcid:0000-0001-9661-5277
PNS injuries initiate a signaling cascade that induces neuroregeneration. This cascade involves activation of ERK, subsequently leading to the activation of PCAF (KAT2B), which in turn mediates histone 3 acetylation, paving the way for transcriptional activation of the key genes in the regeneration program.
peripheral nervous system injury
pubmed:24686445
orcid:0000-0001-9661-5277
Murine monoclonal IgG recognizing the phosphatase-activating domain (PAD) of tau
Tau antibody, TNT1
pubmed:27260838
orcid:0000-0001-9661-5277
Murine monoclonal IgG recognizing the phosphatase-activating domain (PAD) of tau
Tau antibody, TNT2
pubmed:27260838
orcid:0000-0001-9661-5277
One of the major endogenus cGMP derivatives, a class of second messengers in the nitric oxide signalling pathway. It modifies the target protein's cysteine residues via a stable sulfide bond through the NO group of the guanine base, in a post translational modification also known as S-guanylation, a process involved in the regulation of the physiological roles of several important proteins. The S-guanylation of tau was shown to block the aggregation process and the subsequent formation of tau oligomers.
8-nitro-cGMP
pubmed:27601475
pubmed:28213625
chebi:CHEBI:136665
inchi:InChI=1S/C10H11N6O9P/c11-9-13-6-3(7(18)14-9)12-10(16(19)20)15(6)8-4(17)5-2(24-8)1-23-26(21,22)25-5/h2,4-5,8,17H,1H2,(H,21,22)(H3,11,13,14,18)/t2-,4-,5-,8-/m1/s1
smiles:N1C(=NC2=C(N=C(N2[C@@H]3O[C@@H]4COP(O[C@H]4[C@H]3O)(=O)O)[N+]([O-])=O)C1=O)N
orcid:0000-0001-9661-5277
A key intermediate product of tau oligomerization to PHF and NFT formation, they consist of covalently linked antiparallel tau monomers presenting disulfide cross links between cystein residues.
Tau dimers
pubmed:10899437
pubmed:27373205
orcid:0000-0001-9661-5277
A post-translational modification consisting on the addition and covalent bonding of multiple SUMO (small ubiquitin-like modifiers) proteins to lysine residues of target proteins, mediating a wide range of physiological functions. Polysumoylation of APP was found to reduce the generation of amyloid beta peptides, while mono or under-sumoylation enhance Ab generation.
polysumoylation
pubmed:12506199
orcid:0000-0001-9661-5277
Detyrosination is a form of posttranslational modification that occurs on alpha-tubulin. It consists of the removal of the C-terminal tyrosine to expose a glutamate at the newly formed C-terminus.
detyrosination
pubmed:25974414
orcid:0000-0001-9661-5277
Antibodies for the Tau protein (HGNC:MAPT)
Tau antibody
pubmed:23666762
pubmed:28408124
pubmed:26751493
pubmed:27260838
orcid:0000-0003-4423-4370
Epitopes targed by antibodies for the Tau protein (HGNC:MAPT)
Tau epitope
pubmed:23666762
pubmed:28408124
pubmed:26751493
pubmed:27260838
orcid:0000-0003-4423-4370
A partial agonist at α7 nAChR
S 24795
2-[2-(4-Bromophenyl)-2-oxoethyl]-1-methylpyridinium iodide
2-[2-(4-bromophenyl)-2-oxoethyl]-1-methylpyridiniumiodide
304679-75-2
AKOS024457657
API0014115
KB-80442
LERUHBBUGAOYOD-UHFFFAOYSA-M
MolPort-023-276-831
S 24795
S 24795, >=98% (HPLC)
SCHEMBL5948853
pubmed:18187166
pubmed:18265960
pubmed:18034231
chemspider:8063920
inchi:InChI=1S/C14H13BrNO.HI/c1-16-9-3-2-4-13(16)10-14(17)11-5-7-12(15)8-6-11;/h2-9H,10H2,1H3;1H/q+1;/p-1
pubchem.compound:9888248
smiles:C[N+]1=CC=CC=C1CC(=O)C2=CC=C(C=C2)Br.[I-]
orcid:0000-0003-4423-4370
GTS-21 is a derivative of the natural product anabaseine that acts as a partial agonist at neural nicotinic acetylcholine receptors. It binds to both the α4β2 and α7 subtypes, but activates only the α7 to any significant extent.
GTS-21
(3E)-3-(2,4-dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine
(3E)-3-[(2,4-DIMETHOXYPHENYL)METHYLIDENE]-3,4,5,6-TETRAHYDRO-2,3''-BIPYRIDINE
(3e)-3-[(2,4-Dimethoxyphenyl)methylidene]-3,4,5,6-Tetrahydro-2,3'-Bipyridine
148372-04-7
2,3'-Bipyridine, 3-((2,4-dimethoxyphenyl)methylene)-3,4,5,6-tetrahydro-, (3E)-
2,3'-Bipyridine, 3-[(2,4-dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-, hydrochloride (1:2), (3E)-
2,4-Dimethoxybenzylidene anabaseine
2wnj
3 (2,4 dimethoxybenzylidene)anabaseine
3,4,5,6-Tetrahydro-3-(2,4-dimethoxybenzylidene)-2,3'-bipyridine
3-(2,4-Dimethoxy-benzylidene)-3,4,5,6-tetrahydro-[2,3']bipyridinyl
3-(2,4-Dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine
3-(2,4-dimethoxybenzylidene)anabaseine
3-(3-(2,4-dimethoxybenzylidene)-3,4,5,6-tetrahydropyridin-2-yl)pyridine
3-(4-hydroxy-2-methoxybenzylidene)anabaseine
3-[(2,4-dimethoxy)benzylidene]-anabaseine
3-[(2,4-dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-2,3'-Bipyridine
3-[(3E)-3-[(2,4-DIMETHOXYPHENYL)METHYLIDENE]-5,6-DIHYDRO-4H-PYRIDIN-2-YL]PYRIDINE
3-[(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-3,4,5,6-tetrahydropyridin-2-yl]pyridine
3-[(5E)-5-[(2,4-dimethoxyphenyl)methylidene]-3,4-dihydro-2H-pyridin-6-yl]pyridine
3-[(E)-(2,4-Dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-2,3'-bipyridine
3-[1-(2,4-Dimethoxy-phenyl)-meth-(E)-ylidene]-3,4,5,6-tetrahydro-[2,3'']bipyridinyl
419A471
8S399XDN2K
A15950
AC1NSJRW
AKOS005146470
ASIS-0106
BBL035625
BDBM50061564
BDBM86543
C19905
CAS_156223-05-1
CHEMBL134713
DB05708
DMXB-A
Dimethoxybenzylidene anabaseine
GTS 21
GTS-21
Gts-21
KB-77635
MolPort-004-975-791
NSC_122225
SCHEMBL316745
SCHEMBL316746
STL441849
UNII-8S399XDN2K
X5074
X5075
ZINC860
pubmed:25514383
chemspider:4470526
drugbank:DB05708
inchi:InChI=1S/C19H20N2O2/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16/h3,6-9,11-13H,4-5,10H2,1-2H3/b15-11+
pubchem.compound:5310985
smiles:[H]\C(=C1\CCCN=C1C1=CN=CC=C1)C1=C(OC)C=C(OC)C=C1
orcid:0000-0003-4423-4370
nAChR subtype found in cortex, hippocampus and neostriatum
alpha-4 alpha-5 beta-2 nAChR
pubmed:19721446
orcid:0000-0002-3034-9970
complex(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2))
nAChR subtype found in hippocampus, pineal gland and cerebellum
alpha-3 beta-4 nAChR
pubmed:19721446
orcid:0000-0002-3034-9970
complex(p(HGNC:CHRNA3), p(HGNC:CHRNB4))
nAChR subtype found in habenula and interpeduncular nucleus
alpha-3 beta-3 beta-4 nAChR
pubmed:19721446
orcid:0000-0002-3034-9970
nAChR subtype found in locus coeruleus, substantia nigra and neostriatum
alpha-6 beta-2 beta-3 nAChR
pubmed:19721446
orcid:0000-0002-3034-9970
nAChR subtype found in interpeduncular nucleus
alpha-2 beta-2 nAChR
pubmed:19721446
orcid:0000-0002-3034-9970
nAChR subtype found in neostriatum
alpha-6 alpha-4 beta-2 beta-3 nAChR
pubmed:19721446
orcid:0000-0002-3034-9970
Protein aggregation occurs in vivo as a result of improper folding or misfolding
protein aggregation
pubmed:11831622
orcid:0000-0002-6117-4413
the process of assembling a receptor pentamer from the Nicotinic acetylcholine receptors subunits
nAChR assembly
pubmed:19126755
orcid:0000-0002-3034-9970
A metabolic product of GTS-21 (HBP:CONSO00310) in which the methoxy at the 4-position has been cleaved to leave a hydroxyl
4-OH-GTS-21
3-(4-hydroxy-2-methoxybenzylidene) anabaseine
3-(4-hydroxy-2-methoxybenzylidene)anabaseine
4OH-GTS-21
pubmed:25514383
inchi:InChI=1S/C18H18N2O2/c1-22-17-11-16(21)7-6-13(17)10-14-4-3-9-20-18(14)15-5-2-8-19-12-15/h2,5-8,10-12,21H,3-4,9H2,1H3/b14-10+
mesh:C116666
smiles:COC1=C(C=CC(=C1)O)C=C2CCCN=C2C3=CC=CN=C3
orcid:0000-0003-4423-4370
An animal model in which rats, immediately after weaning (usually postnatal day 21), are housed in isolation from siblings for an extended period (usually several weeks). In adulthood, these animals show many characteristics also seen in patients with schizophrenia
isolation rearing
pubmed:16820021
orcid:0000-0002-0303-8616
A chemical that inhibits the aggregation of the Tau protein (HGNC:MAPT) as form paired helical fragments (PHFs), straight filaments (SFs), oligomers, and larger aggregates
Tau aggregation inhibitor
pubmed:23484434
chebi:CHEBI:142738
orcid:0000-0003-4423-4370
A thiazole with two amino substituents
1,3-Thiazole-2,4-diamine
1,3-thiazole-2,4-diamine
2,4-thiazolediamine
67355-26-4
AB0070905
AB00987320-01
AC1L3O08
AC1Q4VRF
AJ-67953
AK-30756
AKOS009092919
ANW-58036
BS-12711
F2145-0277
FT-0707053
KB-261000
M-8345
MCULE-4736308679
MFCD06738274
MolPort-002-471-220
QC-6319
SCHEMBL461605
ST24031901
TC-146781
Thiazole-2,4-diamine
Z5019
ZINC15863137
diaminothiazole
pubmed:21353545
pubmed:20524425
pubmed:11148059
inchi:InChI=1S/C3H5N3S/c4-2-1-7-3(5)6-2/h1H,4H2,(H2,5,6)
pubchem.compound:118995
smiles:C1=C(N=C(S1)N)N
orcid:0000-0003-4423-4370
Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is a genetic form of epilepsy that is caused by mutations in several genes, including genes encoding for the α4 and β2 subunits of the nicotinic acetylcholine (nACh) receptor
Autosomal Dominant Nocturnal Frontal Lobe Epilepsy
pubmed:30472464
doid:DOID:0060681
mesh:C579932
orcid:0000-0002-6117-4413
Anti-Ubiquitinylated proteins Antibod
FK1 antibody
pubmed:16338350
orcid:0000-0002-3034-9970
monoclonal antibody that is specific for amyloid-beta oligomers
amyloid-beta antibody, NU1
pubmed:17403556
orcid:0000-0002-3034-9970
Here we report the discovery and characterization of 3-(3,4-difluorophenyl)-N-(1-(6-(4-(pyridin-2-yl)piperazin-1-yl)pyrazin-2-yl)ethyl)propanamide (B-973), a piperazine containing α7 type II PAM
B-973
pubmed:28132910
inchi:InChI=1S/C24H26F2N6O/c1-17(29-24(33)8-6-18-5-7-19(25)20(26)14-18)21-15-27-16-23(30-21)32-12-10-31(11-13-32)22-4-2-3-9-28-22/h2-5,7,9,14-17H,6,8,10-13H2,1H3,(H,29,33)/t17-/m0/s1
smiles:C1=C(C(=CC=C1CCC(N[C@H](C2=CN=CC(=N2)N3CCN(CC3)C4=NC=CC=C4)C)=O)F)F
orcid:0000-0002-6117-4413
An alignment of residues in the M3-M4 loop of alpha-7 nAChR that contribute to the binding of G-protein
GPBC, alpha-7 nAChR
pubmed:24185813
pubmed:26088141
orcid:0000-0002-3034-9970
An alignment of residues in the M3-M4 loop of GPBC, Glycine Receptor 1 (GLRA1) that contribute to the binding of G-protein
GPBC, Glycine Receptor 1
pubmed:24185813
pubmed:26088141
orcid:0000-0002-3034-9970
N-terminal fragment of the protein ATF6, generated by cleavage through SP1 and SP2 proteases
N-terminal fragment of ATF6
pubmed:25784053
orcid:0000-0002-7128-929X
Proteins that are not able to achieve the native state, due either to an unwanted mutation in their amino acid sequence or simply because of an error in the folding process, are recognized as misfolded and subsequently targeted to a degradation pathway
misfolded
pubmed:16689923
orcid:0000-0002-6117-4413
A novel cholestane glycoside called OSW-1 (3b, 16b, 17a-trihydroxycholest-5-en-22-one 16-O-(2-O-4-methoxybenzoyl-bD-xylopyranosyl) - (1?3) -(2-O-acetyl-a-L-arabinopyranoside)) was recently isolated from Ornithogalum saundersiae (Kubo et al., 1992) and has been found to have a potent growth inhibitory activity on a human tumour cell line
OSW-1
145075-81-6
CHEMBL375269
CS-0020992
HY-101213
OSW-1
SCHEMBL17383554
ZINC169358856
pubmed:9283720
chebml:CHEMBL375269
inchi:InChI=1S/C47H68O15/c1-24(2)8-15-34(50)25(3)47(55)37(21-33-31-14-11-28-20-29(49)16-18-45(28,5)32(31)17-19-46(33,47)6)60-44-41(59-26(4)48)39(36(52)23-58-44)62-43-40(38(53)35(51)22-57-43)61-42(54)27-9-12-30(56-7)13-10-27/h9-13,24-25,29,31-33,35-41,43-44,49,51-53,55H,8,14-23H2,1-7H3/t25-,29+,31-,32+,33+,35-,36+,37+,38+,39+,40-,41-,43+,44+,45+,46+,47-/m1/s1
mesh:C106408
pubchem.compound:9854230
smiles:COc1ccc(cc1)C(=O)O[C@@H]2[C@@H](O)[C@H](O)CO[C@H]2O[C@H]3[C@@H](O)CO[C@@H](O[C@H]4C[C@H]5[C@@H]6CC=C7C[C@@H](O)CC[C@]7(C)[C@H]6CC[C@]5(C)[C@@]4(O)[C@H](C)C(=O)CCC(C)C)[C@@H]3OC(=O)C
orcid:0000-0002-6117-4413
low–molecular weight Hsp90 N-terminal domain inhibitor
EC102
pubmed:17304350
orcid:0000-0002-7128-929X
inhibitor of Aha1
KU-177
pubmed:28827321
orcid:0000-0002-7128-929X
Ubb+1, a ubiquitin (Ub) mutant protein originating from misreading of the Ub B gene
UBB+1
pubmed:29175520
orcid:0000-0002-7128-929X
inhibitor of tau aggregation and toxicity in vitro and in cells
Phenylthiazolyl-hydrazide
pubmed:17685560
orcid:0000-0002-6117-4413
an acidic motif,EEVD, located at the extreme carboxyl terminus of nearly all Hsp7Os which has an essential role in regulating the biochemical properties of Hsp7O and interactions with HDJ-1
EEVD motif
pubmed:7774586
orcid:0000-0002-6117-4413
Hsp27 exists as an ensemble of oligomers,which range in size from dimers to approximately 32 mers or greater
Hsp27 oligomers
pubmed:21882945
orcid:0000-0002-6117-4413
a dopamine D1 receptor partial agonist
SK and F 77434
pubmed:16820021
orcid:0000-0002-0303-8616
a new selective iodinated salicylamide ligand for the labelling of dopamine D2 receptors with 125I.
[125I]-NCQ 298
pubmed:16820021
orcid:0000-0002-0303-8616
Adeno-associated virus expressing Mouse Fkbp1b.
AAV-FKBP1B
pubmed:29255009
orcid:0000-0002-0303-8616
Regulation of the concentration, folding, interactions, and cellular localization of each of the proteins that comprise the proteome
Proteostasis
pubmed:29127110
mesh:D000074702
orcid:0000-0002-7128-929X
Fragment of APP (N-APP) that contains heparin-binding and metal-binding domains and that has been found to have biological activity
N-terminal fragment of APP
pubmed:24916405
orcid:0000-0002-2046-6145
p(HGNC:APP, frag(1_?))
Aggregates due to mutations of proteins that lead to polyQ expansions
polyQ aggregates
pubmed:23483542
orcid:0000-0002-7128-929X
Aggregates of proteins consisting of polyglutamine stretches with 82 glutamine residues
Q82 aggregates
pubmed:10811890
orcid:0000-0002-7128-929X
Post-translational protein modifications that were not caused by enzymatic reactions
non-enzymatic protein modification
pubmed:24563850
orcid:0000-0002-7128-929X
Tau aggregation inhibitor bb14 (from the rhodanine class of compounds)
bb14
pubmed:26510979
orcid:0000-0002-7128-929X
Tau aggregation inhibitor
cmp16
pubmed:20392114
orcid:0000-0002-7128-929X
Proteins that are not able to achieve the native state, due either to an unwanted mutation in their amino acid sequence or simply because of an error in the folding process, are recognized as misfolded and subsequently targeted to a degradation pathway
misfolding
pubmed:16689923
orcid:0000-0002-7128-929X
ABAD inhibitor
AG18051
pubmed:22174920
inchi:InChI=1S/C19H21N5OS/c25-18(23-10-6-1-2-7-11-23)16(14-8-4-3-5-9-14)24-13-20-17-15(19(24)26)12-21-22-17/h3-5,8-9,12-13,16H,1-2,6-7,10-11H2,(H,21,22)
smiles:C1=N[N]C2=C1C(=S)N(C=N2)C(C(=O)C3CCCCCC3)C4=CC=CC=C4
orcid:0000-0002-7128-929X
ABAD inhibitor
RM-532-46
pubmed:22674910
inchi:InChI=1S/C30H44N2O3/c1-35-23-4-2-3-21(17-23)19-31-13-15-32(16-14-31)20-30(34)12-11-24-22(18-30)5-6-26-25(24)7-8-28-27(26)9-10-29(28)33/h2-4,17,22,24-28,34H,5-16,18-20H2,1H3/t22-,24-,25+,26+,27-,28-,30+/m0/s1
smiles:C1[C@H]4[C@H](C[C@](C1)(CN2CCN(CC2)CC3=CC(=CC=C3)OC)O)CC[C@@H]5[C@@H]4CC[C@H]6[C@H]5CCC6=O
orcid:0000-0002-7128-929X
The removal of an amide group from a peptide's side chain
deamidation
pubmed:26631930
orcid:0000-0003-4423-4370
A standardized and structured interview originally developed by Marshal Folstein, Susan Folstein and Paul McHugh (Journal of Psychiatric Research, 1975), which is used to evaluate an individual's cognitive function.
Mini-Mental Status Exam
Folstein Mini-Mental Status Exam
MMS1
MMSE
Mini-Mental State Examination Questionnaire
Mini-Mental_Status_Exam
ncit:C74982
umls:C0451306
orcid:0000-0003-4423-4370
glyceraldehyde-derived pyridinium-type advanced glycation end product (AGE), formed by glyceraldehyde-related glycation
GLAP
1-(5-acetylamino-5-carboxypentyl)-3-hydroxy-5-hydroxymethyl-pyridinium
Glyceraldehyde derived Pyridinium compound
Glyceraldehyde-derived Pyridinium compound
pubmed:25582325
pubmed:17284838
inchi:InChI=1S/C12H18N2O4/c13-4-2-1-3-11(12(17)18)14-6-9(8-15)5-10(16)7-14/h5-7,11,15H,1-4,8,13H2,(H-,16,17,18)/t11-/m0/s1
smiles:NCCCC[C@@H](C(=O)O)[N+]1=CC(=CC(=C1)[O-])CO
orcid:0000-0002-7128-929X
In addition to the 3′ splice site at the end of exon 6, there are two alternate 3′ splice sites within exon 6 itself, termed “6P” and “6D” according to location (Fig. 1). Use of either of these splice sites results in a frame shift that introduces a unique amino acid sequence, PCCVPRATFLS (6P) or FWSKGDETQGG (6D), followed by a stop codon. As a result, tau 6P and 6D isoforms are truncated, lacking part of the proline-rich region, the MTBR region, and C-terminus
Tau 6D
pubmed:21734277
pubmed:19919107
orcid:0000-0002-6117-4413
In addition to the 3′ splice site at the end of exon 6, there are two alternate 3′ splice sites within exon 6 itself, termed “6P” and “6D” according to location (Fig. 1). Use of either of these splice sites results in a frame shift that introduces a unique amino acid sequence, PCCVPRATFLS (6P) or FWSKGDETQGG (6D), followed by a stop codon. As a result, tau 6P and 6D isoforms are truncated, lacking part of the proline-rich region, the MTBR region, and C-terminus
Tau 6P
pubmed:21734277
pubmed:19919107
orcid:0000-0002-6117-4413
Parts of the body that act as a response to a change in the environment, the body's functions, molecule levels, etc.
Peripheral Tissue
pubmed:27758088
orcid:0000-0002-7128-929X
Antibodies, that are able to bind different epitopes of the tau protein
tau polyclonal antibody
pubmed:29590627
orcid:0000-0002-7128-929X
oligomers form during the early steps of TDP-43 misfolding
TDP-43 oligomers
pubmed:30824544
orcid:0000-0002-6117-4413
TDP-43 aggregates are formed through a biphasic process that initiates with oligomerization followed by aggregation into high molecular weight polymers
TDP-43 aggregates
pubmed:30824544
orcid:0000-0002-6117-4413
Multiplication or reproduction by cell division of a population of identical cells descended from a single progenitor. In immunology, may refer to the clonal proliferation of cells responsive to a specific antigen as part of an immune response.
Clonal Expansion
pubmed:27794524
ncit:C20613
orcid:0000-0002-7683-0452
Clinical Dementia Rating (CDR) Sum of Boxes
CDR - Sum of Boxes
pubmed:25468261
pubmed:23626081
pubmed:27084223
ncit:C113880
umls:C3827230
orcid:0000-0003-4423-4370
mouse monoclonal antibody specific to tau epitopes within 312 to 322 amino acid
Tau antibody, MC1
pubmed:28148553
pubmed:21841002
pubmed:23638068
antibodyregistry:AB_2314773
orcid:0000-0002-7683-0452
recombinant mouse antibody specifc to MAPT
DC8E8
pubmed:4255369
pubmed:25478017
pdb:4OZ4
url:https://www.creativebiolabs.net/Anti-Tau-Antibody-24886.htm
orcid:0000-0002-7683-0452
monoclonal mouse antibody specifc to MAPT
DC11
pubmed:4255369
pubmed:12544837
orcid:0000-0002-7683-0452
recombinant mouse antibody binding to PHF core of MAPT
MN423
pubmed:4255369
pubmed:25478017
pdb:2V17
url:https://www.creativebiolabs.net/Anti-PHF-core-Antibody-24396.htm
orcid:0000-0002-7683-0452
active vaccine eliciting an immune response against pathologically modified forms of tau protein
AADvac1
pubmed:25478017
url:https://www.alzforum.org/therapeutics/aadvac1
orcid:0000-0002-7683-0452
HDAC3 inhibitor
RGFP136
N-(6-(2-amino-4-fluorophenylamino)-6-oxohexyl)-4-methylbenzamide
RGFP 136
pubmed:21228185
pubmed:23356410
inchi:InChI=1S/C20H24FN3O2/c1-14-6-8-15(9-7-14)20(26)23-12-4-2-3-5-19(25)24-18-11-10-16(21)13-17(18)22/h6-11,13H,2-5,12,22H2,1H3,(H,23,26)(H,24,25)
mesh:C556032
smiles:NC1=C(C=CC(=C1)F)NC(CCCCCNC(C1=CC=C(C=C1)C)=O)=O
orcid:0000-0002-7683-0452
Compounds that inhibit Histone Deactelylase 3(HDAC-3)
HDAC3 inhibitor
pubmed:21228185
pubmed:23356410
orcid:0000-0002-7683-0452
Long-term chemotherapy-induced cognitive decline in cancer survivors
chemofog
CICI
Chemotherapy-induced cognitive impairment
chemo brain
chemobrain
pubmed:30112764
pubmed:28916767
pubmed:30382534
orcid:0000-0003-4423-4370
neuropathy caused by chemotherapy
Chemotherapy-induced peripheral neuropathy
CIPN
chemotherapy induced peripheral neuropathy
pubmed:31363906
pubmed:25256375
pubmed:31783290
pubmed:24830939
pubmed:30244980
orcid:0000-0003-4423-4370
chemotherapy induced peripheral neuropathy
pubmed:25256375
CIPN
pubmed:25256375
chemobrain
pubmed:20832978
chemo brain
pubmed:20832978
Chemotherapy-induced cognitive impairment
pubmed:20832978
CICI
pubmed:20832978
RGFP 136
mesh:C556032
N-(6-(2-amino-4-fluorophenylamino)-6-oxohexyl)-4-methylbenzamide
mesh:C556032
Glyceraldehyde-derived Pyridinium compound
pubmed:12784645
Glyceraldehyde derived Pyridinium compound
pubmed:12784645
1-(5-acetylamino-5-carboxypentyl)-3-hydroxy-5-hydroxymethyl-pyridinium
pubmed:12784645
Mini-Mental_Status_Exam
ncit:C74982
Mini-Mental State Examination Questionnaire
ncit:C74982
MMSE
ncit:C74982
MMS1
ncit:C74982
Folstein Mini-Mental Status Exam
ncit:C74982
ZINC169358856
pubchem.compound:9854230
SCHEMBL17383554
pubchem.compound:9854230
OSW-1
pubchem.compound:9854230
HY-101213
pubchem.compound:9854230
CS-0020992
pubchem.compound:9854230
CHEMBL375269
pubchem.compound:9854230
145075-81-6
pubchem.compound:9854230
diaminothiazole
pubchem.compound:118995
ZINC15863137
pubchem.compound:118995
Z5019
pubchem.compound:118995
Thiazole-2,4-diamine
pubchem.compound:118995
TC-146781
pubchem.compound:118995
ST24031901
pubchem.compound:118995
SCHEMBL461605
pubchem.compound:118995
QC-6319
pubchem.compound:118995
MolPort-002-471-220
pubchem.compound:118995
MFCD06738274
pubchem.compound:118995
MCULE-4736308679
pubchem.compound:118995
M-8345
pubchem.compound:118995
KB-261000
pubchem.compound:118995
FT-0707053
pubchem.compound:118995
F2145-0277
pubchem.compound:118995
BS-12711
pubchem.compound:118995
ANW-58036
pubchem.compound:118995
AKOS009092919
pubchem.compound:118995
AK-30756
pubchem.compound:118995
AJ-67953
pubchem.compound:118995
AC1Q4VRF
pubchem.compound:118995
AC1L3O08
pubchem.compound:118995
AB00987320-01
pubchem.compound:118995
AB0070905
pubchem.compound:118995
67355-26-4
pubchem.compound:118995
2,4-thiazolediamine
pubchem.compound:118995
1,3-thiazole-2,4-diamine
pubchem.compound:118995
4OH-GTS-21
mesh:C116666
3-(4-hydroxy-2-methoxybenzylidene)anabaseine
pubmed:25514383
3-(4-hydroxy-2-methoxybenzylidene) anabaseine
pubmed:25514383
ZINC860
pubchem.compound:5310985
X5075
pubchem.compound:5310985
X5074
pubchem.compound:5310985
UNII-8S399XDN2K
pubchem.compound:5310985
STL441849
pubchem.compound:5310985
SCHEMBL316746
pubchem.compound:5310985
SCHEMBL316745
pubchem.compound:5310985
NSC_122225
pubchem.compound:5310985
MolPort-004-975-791
pubchem.compound:5310985
KB-77635
pubchem.compound:5310985
Gts-21
pubchem.compound:5310985
GTS-21
drugbank:DB05708
GTS 21
pubmed:25514383
Dimethoxybenzylidene anabaseine
pubchem.compound:5310985
DMXB-A
pubchem.compound:5310985
DB05708
pubchem.compound:5310985
CHEMBL134713
pubchem.compound:5310985
CAS_156223-05-1
pubchem.compound:5310985
C19905
pubchem.compound:5310985
BDBM86543
pubchem.compound:5310985
BDBM50061564
pubchem.compound:5310985
BBL035625
pubchem.compound:5310985
ASIS-0106
pubchem.compound:5310985
AKOS005146470
pubchem.compound:5310985
AC1NSJRW
pubchem.compound:5310985
A15950
pubchem.compound:5310985
8S399XDN2K
pubchem.compound:5310985
419A471
pubchem.compound:5310985
3-[1-(2,4-Dimethoxy-phenyl)-meth-(E)-ylidene]-3,4,5,6-tetrahydro-[2,3'']bipyridinyl
pubchem.compound:5310985
3-[(E)-(2,4-Dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-2,3'-bipyridine
pubchem.compound:5310985
3-[(5E)-5-[(2,4-dimethoxyphenyl)methylidene]-3,4-dihydro-2H-pyridin-6-yl]pyridine
pubchem.compound:5310985
3-[(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-3,4,5,6-tetrahydropyridin-2-yl]pyridine
drugbank:DB05708
3-[(3E)-3-[(2,4-DIMETHOXYPHENYL)METHYLIDENE]-5,6-DIHYDRO-4H-PYRIDIN-2-YL]PYRIDINE
pubchem.compound:5310985
3-[(2,4-dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-2,3'-Bipyridine
pubchem.compound:5310985
3-[(2,4-dimethoxy)benzylidene]-anabaseine
pubchem.compound:5310985
3-(4-hydroxy-2-methoxybenzylidene)anabaseine
pubmed:25514383
3-(3-(2,4-dimethoxybenzylidene)-3,4,5,6-tetrahydropyridin-2-yl)pyridine
pubchem.compound:5310985
3-(2,4-dimethoxybenzylidene)anabaseine
pubchem.compound:5310985
3-(2,4-Dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine
pubchem.compound:5310985
3-(2,4-Dimethoxy-benzylidene)-3,4,5,6-tetrahydro-[2,3']bipyridinyl
pubchem.compound:5310985
3,4,5,6-Tetrahydro-3-(2,4-dimethoxybenzylidene)-2,3'-bipyridine
pubchem.compound:5310985
3 (2,4 dimethoxybenzylidene)anabaseine
pubchem.compound:5310985
2wnj
pubchem.compound:5310985
2,4-Dimethoxybenzylidene anabaseine
pubchem.compound:5310985
2,3'-Bipyridine, 3-[(2,4-dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-, hydrochloride (1:2), (3E)-
pubchem.compound:5310985
2,3'-Bipyridine, 3-((2,4-dimethoxyphenyl)methylene)-3,4,5,6-tetrahydro-, (3E)-
pubchem.compound:5310985
148372-04-7
pubchem.compound:5310985
(3e)-3-[(2,4-Dimethoxyphenyl)methylidene]-3,4,5,6-Tetrahydro-2,3'-Bipyridine
pubchem.compound:5310985
(3E)-3-[(2,4-DIMETHOXYPHENYL)METHYLIDENE]-3,4,5,6-TETRAHYDRO-2,3''-BIPYRIDINE
pubchem.compound:5310985
(3E)-3-(2,4-dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine
pubchem.compound:5310985
SCHEMBL5948853
pubchem.compound:9888248
S 24795, >=98% (HPLC)
pubchem.compound:9888248
S 24795
pubchem.compound:9888248
MolPort-023-276-831
pubchem.compound:9888248
LERUHBBUGAOYOD-UHFFFAOYSA-M
pubchem.compound:9888248
KB-80442
pubchem.compound:9888248
API0014115
pubchem.compound:9888248
AKOS024457657
pubchem.compound:9888248
304679-75-2
pubchem.compound:9888248
2-[2-(4-bromophenyl)-2-oxoethyl]-1-methylpyridiniumiodide
pubchem.compound:9888248
2-[2-(4-Bromophenyl)-2-oxoethyl]-1-methylpyridinium iodide
pubchem.compound:9888248
s2823
pubchem.compound:11313622
ZINC13985228
pubchem.compound:11313622
X5395
pubchem.compound:11313622
W-5777
pubchem.compound:11313622
UNII-Q747Y6TT42
pubchem.compound:11313622
Tideglusib,CAS:865854-05-3
pubchem.compound:11313622
Tideglusib, >=98% (HPLC)
pubchem.compound:11313622
Tideglusib(NP-031112)
pubchem.compound:11313622
Tideglusib [INN]
pubchem.compound:11313622
Tideglusib (NP031112, NP-12)
pubchem.compound:11313622
Tideglusib
pubchem.compound:11313622
SCHEMBL676929
pubchem.compound:11313622
SB19268
pubchem.compound:11313622
RL05359
pubchem.compound:11313622
Q747Y6TT42
pubchem.compound:11313622
NP031112
pubchem.compound:11313622
NP-12
pubchem.compound:11313622
NP-031112|||4-Benzyl-2-naphthalen-1-yl-1,2,4-thiadiazolidine-3,5-dione
pubchem.compound:11313622
NP-031112
pubchem.compound:11313622
NP 031112
pubchem.compound:11313622
MolPort-028-599-952
pubchem.compound:11313622
MFCD18633296
pubchem.compound:11313622
KB-81154
pubchem.compound:11313622
J-514478
pubchem.compound:11313622
HY-14872
pubchem.compound:11313622
GTPL6929
pubchem.compound:11313622
FT-0700382
pubchem.compound:11313622
EX-A600
pubchem.compound:11313622
DTXSID90235682
pubchem.compound:11313622
DB12129
pubchem.compound:11313622
DA-41071
pubchem.compound:11313622
D0UT7X
pubchem.compound:11313622
CS-0613
pubchem.compound:11313622
CHEMBL3545157
pubchem.compound:11313622
C19H14N2O2S
pubchem.compound:11313622
BDBM50166940
pubchem.compound:11313622
BCP06016
pubchem.compound:11313622
BC600768
pubchem.compound:11313622
AOB5562
pubchem.compound:11313622
AKOS025149085
pubchem.compound:11313622
AK176015
pubchem.compound:11313622
865854-05-3
pubchem.compound:11313622
4CA-1249
pubchem.compound:11313622
4-benzyl-2-naphthalen-1-yl-1,2,4-thiadiazolidine-3,5-dione
pubchem.compound:11313622
4-benzyl-2-(naphthalen-1-yl)-(1,2,4)thiadiazolidine-3,5-dione
pubchem.compound:11313622
4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione
pubchem.compound:11313622
4-Benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione
pubchem.compound:11313622
1,2,4-Thiadiazolidine-3,5-dione, 2-(1-naphthalenyl)-4-(phenylmethyl)-
pubchem.compound:11313622
ZINC5699183
pubchem.compound:54682951
X033PDI962
pubchem.compound:54682951
UNII-X033PDI962
pubchem.compound:54682951
Sudoxicamum [INN-Latin]
pubchem.compound:54682951
Sudoxicamum
pubchem.compound:54682951
Sudoxicam [USAN:INN:BAN]
pubchem.compound:54682951
Sudoxicam [USAN:BAN:INN]
pubchem.compound:54682951
Sudoxicam (USAN/INN)
pubchem.compound:54682951
SYCHUQUJURZQMO-UHFFFAOYSA-N
pubchem.compound:54682951
SUDOXICAM
pubchem.compound:54682951
SMR004701482
pubchem.compound:54682951
SCHEMBL35068
pubchem.compound:54682951
SCHEMBL35067
pubchem.compound:54682951
Oprea1_704902
pubchem.compound:54682951
NSC615046
pubchem.compound:54682951
NSC-615046
pubchem.compound:54682951
NSC 615046
pubchem.compound:54682951
N-(2-Thiazolyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-Dioxide
pubchem.compound:54682951
MLS006010801
pubchem.compound:54682951
LS-40541
pubchem.compound:54682951
J-019435
pubchem.compound:54682951
FT-0674694
pubchem.compound:54682951
EINECS 251-808-7
pubchem.compound:54682951
DTXSID50187653
pubchem.compound:54682951
D05937
pubchem.compound:54682951
CTK8G3246
pubchem.compound:54682951
CP-15973
pubchem.compound:54682951
CP-15,973
pubchem.compound:54682951
CP 15973
pubchem.compound:54682951
CHEMBL20634
pubchem.compound:54682951
BRN 0628704
pubchem.compound:54682951
AKOS030239604
pubchem.compound:54682951
ACM34042858
pubchem.compound:54682951
AC1NSM46
pubchem.compound:54682951
AC1NSEW2
pubchem.compound:54682951
AC1L1W79
pubchem.compound:54682951
4-hydroxy-2-methyl-N-(2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide
pubchem.compound:54682951
4-hydroxy-2-methyl-1,1-dioxo-N-thiazol-2-yl-1$l^{6},2-benzothiazine-3-carboxamide
pubchem.compound:54682951
4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
pubchem.compound:54682951
4-Hydroxy-2-methyl-N-1,3-thiazol-2-yl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
pubchem.compound:54682951
4-Hydroxy-2-methyl-N-(1,3-thiazol-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
pubchem.compound:54682951
34042-85-8
pubchem.compound:54682951
3-[hydroxy-(1,3-thiazol-2-ylamino)methylidene]-2-methyl-1,1-dioxo-1
pubchem.compound:54682951
2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-thiazolyl-, 1,1-dioxide
pubchem.compound:54682951
(3Z)-3-[hydroxy-(1,3-thiazol-2-ylamino)methylidene]-2-methyl-1,1-dioxo-1
pubchem.compound:54682951
(3E)-3-[hydroxy-(1,3-thiazol-2-ylamino)methylidene]-2-methyl-1,1-dioxo-1
pubchem.compound:54682951
hydroxyoxazolinone
pubchem.compound:97389
ZINC1709820
pubchem.compound:97389
Z56762271
pubchem.compound:97389
UNII-R22D15229R
pubchem.compound:97389
TC-146724
pubchem.compound:97389
SCHEMBL8159833
pubchem.compound:97389
SCHEMBL1395587
pubchem.compound:97389
SCHEMBL123971
pubchem.compound:97389
SC-49693
pubchem.compound:97389
R22D15229R
pubchem.compound:97389
Oxazolidinedione
pubchem.compound:97389
OXAZOLIDINE-2,4-DIONE
pubchem.compound:97389
NSC120350
pubchem.compound:97389
NSC-120350
pubchem.compound:97389
NSC 120350
pubchem.compound:97389
MolPort-018-280-326
pubchem.compound:97389
MFCD02691902
pubchem.compound:97389
KS-00000MOC
pubchem.compound:97389
KB-67472
pubchem.compound:97389
FT-0704394
pubchem.compound:97389
F2167-1227
pubchem.compound:97389
DS-15871
pubchem.compound:97389
DA-18172
pubchem.compound:97389
CTK0H9315
pubchem.compound:97389
COWNFYYYZFRNOY-UHFFFAOYSA-N
pubchem.compound:97389
CMLDBU00003511
pubchem.compound:97389
CJ-28984
pubchem.compound:97389
ANW-57979
pubchem.compound:97389
AN-50728
pubchem.compound:97389
AKOS002529400
pubchem.compound:97389
AK-80133
pubchem.compound:97389
AJ-30743
pubchem.compound:97389
AC1L3YF0
pubchem.compound:97389
A816734
pubchem.compound:97389
346O261
pubchem.compound:97389
2346-26-1
pubchem.compound:97389
2,4oxazolidinedione
pubchem.compound:97389
2,4-Oxazolidinedione
pubchem.compound:97389
2,4-Oxazolidenedione
pubchem.compound:97389
1572AB
pubchem.compound:97389
153301-EP2281822A1
pubchem.compound:97389
12770-97-7
pubchem.compound:97389
1,3-oxazolidine-2,4-dione
pubchem.compound:97389
1,3-oxazolidin-2,4-dione
pubchem.compound:97389
purine deriv. 5
pubchem.compound:4592
olomoucine
pubchem.compound:4592
ZX-AFC001655
pubchem.compound:4592
ZINC1641925
pubchem.compound:4592
UPCMLD-DP136:002
pubchem.compound:4592
UPCMLD-DP136:001
pubchem.compound:4592
UPCMLD-DP136
pubchem.compound:4592
UNII-6A839B2HYS
pubchem.compound:4592
Tox21_500883
pubchem.compound:4592
Tocris-1284
pubchem.compound:4592
TRA0035611
pubchem.compound:4592
ST50298830
pubchem.compound:4592
SR-01000075518-6
pubchem.compound:4592
SR-01000075518-3
pubchem.compound:4592
SR-01000075518-1
pubchem.compound:4592
SR-01000075518
pubchem.compound:4592
SMP1_000281
pubchem.compound:4592
SCHEMBL135056
pubchem.compound:4592
RT-014854
pubchem.compound:4592
Olomucine
pubchem.compound:4592
Olomoucine, >=98% (HPLC)
pubchem.compound:4592
OLO
pubchem.compound:4592
O 0886
pubchem.compound:4592
NSC666096
pubchem.compound:4592
NSC-666096
pubchem.compound:4592
NSC 666096
pubchem.compound:4592
NCI60_022916
pubchem.compound:4592
NCGC00261568-01
pubchem.compound:4592
NCGC00025096-07
pubchem.compound:4592
NCGC00025096-06
pubchem.compound:4592
NCGC00025096-05
pubchem.compound:4592
NCGC00025096-04
pubchem.compound:4592
NCGC00025096-03
pubchem.compound:4592
NCGC00025096-02
pubchem.compound:4592
NCGC00025096-01
pubchem.compound:4592
NCGC00015763-09
pubchem.compound:4592
NCGC00015763-08
pubchem.compound:4592
NCGC00015763-07
pubchem.compound:4592
NCGC00015763-06
pubchem.compound:4592
NCGC00015763-05
pubchem.compound:4592
NCGC00015763-04
pubchem.compound:4592
NCGC00015763-03
pubchem.compound:4592
NCGC00015763-02
pubchem.compound:4592
NCGC00015763-01
pubchem.compound:4592
MolPort-003-849-700
pubchem.compound:4592
MFCD00189360
pubchem.compound:4592
Lopac0_000883
pubchem.compound:4592
Lopac-O-0886
pubchem.compound:4592
LP00883
pubchem.compound:4592
Kinome_2870
pubchem.compound:4592
KBioSS_000330
pubchem.compound:4592
KBioGR_000330
pubchem.compound:4592
KBio3_000660
pubchem.compound:4592
KBio3_000659
pubchem.compound:4592
KBio2_005466
pubchem.compound:4592
KBio2_002898
pubchem.compound:4592
KBio2_000330
pubchem.compound:4592
KB-162429
pubchem.compound:4592
J-000453
pubchem.compound:4592
InSolution™ Olomoucine
pubchem.compound:4592
IN1182
pubchem.compound:4592
IN1179
pubchem.compound:4592
IDI1_002090
pubchem.compound:4592
HMS3676E10
pubchem.compound:4592
HMS3650F19
pubchem.compound:4592
HMS3403B11
pubchem.compound:4592
HMS3267L09
pubchem.compound:4592
HMS3262B08
pubchem.compound:4592
HMS1990B11
pubchem.compound:4592
HMS1792B11
pubchem.compound:4592
HMS1362B11
pubchem.compound:4592
GTVPOLSIJWJJNY-UHFFFAOYSA-N
pubchem.compound:4592
FT-0642456
pubchem.compound:4592
Ethanol,2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-
pubchem.compound:4592
Ethanol, 2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-
pubchem.compound:4592
EU-0100883
pubchem.compound:4592
DTXSID90144068
pubchem.compound:4592
DB02116
pubchem.compound:4592
D00BPA
pubchem.compound:4592
CTK4A0020
pubchem.compound:4592
CJ-26517
pubchem.compound:4592
CHEMBL280074
pubchem.compound:4592
CCG-100650
pubchem.compound:4592
CBiol_002050
pubchem.compound:4592
C15H18N6O
pubchem.compound:4592
C-28477
pubchem.compound:4592
BiomolKI_000046
pubchem.compound:4592
BiomolKI2_000052
pubchem.compound:4592
Bio2_000815
pubchem.compound:4592
Bio2_000335
pubchem.compound:4592
Bio1_001314
pubchem.compound:4592
Bio1_000825
pubchem.compound:4592
Bio1_000336
pubchem.compound:4592
BSPBio_000990
pubchem.compound:4592
BRD-K82731415-001-04-7
pubchem.compound:4592
BRD-K82731415-001-03-9
pubchem.compound:4592
BMK1-E10
pubchem.compound:4592
BIO3107
pubchem.compound:4592
BDBM5718
pubchem.compound:4592
BCBcMAP01_000205
pubchem.compound:4592
AKOS005145988
pubchem.compound:4592
ACMC-20cp0o
pubchem.compound:4592
AC1Q4XZU
pubchem.compound:4592
AC1L1IID
pubchem.compound:4592
6A839B2HYS
pubchem.compound:4592
6-benzylamino-2-[2-hydroxyethylamino]-9-methylpurine
pubchem.compound:4592
6-Benzylamino-2-(2-hydroxyethylamino)-9-methylpurine
pubchem.compound:4592
6-Benylamino-2-(2-hydroxyethylamino)-9-methylpurine
pubchem.compound:4592
6-(benzylamino)-2-[(2-hydroxyethyl)amino]-9-methylpurine
pubchem.compound:4592
6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine
pubchem.compound:4592
4erk
pubchem.compound:4592
2-{[6-(benzylamino)-9-methyl-9h-purin-2-yl]amino}ethanol
pubchem.compound:4592
2-{[6-(benzylamino)-9-methyl-9H-purin-2-yl]amino}ethan-1-ol
pubchem.compound:4592
2-[[9-methyl-6-(phenylmethylamino)purin-2-yl]amino]ethanol
pubchem.compound:4592
2-[[9-Methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]ethanol, 9CI
pubchem.compound:4592
2-[[9-Methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]ethanol
pubchem.compound:4592
2-[[9-Methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-ethanol
pubchem.compound:4592
2-[[6-(benzylamino)-9-methylpurin-2-yl]amino]ethanol
pubchem.compound:4592
2-[[6-(benzylamino)-9-methyl-purin-2-yl]amino]ethanol
pubchem.compound:4592
2-({9-methyl-6-[benzylamino]purin-2-yl}amino)ethan-1-ol
pubchem.compound:4592
2-(Hydroxyethylamino)-6-benzylamino-9-methylpurine
pubchem.compound:4592
2-(6-(benzylamino)-9-methyl-9H-purin-2-ylamino)ethanol
pubchem.compound:4592
2-(2-Hydroxyethylamino)-6-benzylamino-9-methylpurine
pubchem.compound:4592
2-(2-Hydroxyethylamino)-6-benzylamino-9-isopropylpurine
pubchem.compound:4592
2-(2-Hydroxyethylamino)-6-(benzylamino)-9-methylpurine
pubchem.compound:4592
2,6,9-Trisubstituted purine deriv. 26
pubchem.compound:4592
1w0x
pubchem.compound:4592
1966AH
pubchem.compound:4592
101622-51-9
pubchem.compound:4592
UNII-9P59GES78D
pubchem.compound:71460273
Maitotoxin 1
pubchem.compound:71460273
Maitotoxin
pubchem.compound:71460273
HSDB 7753
pubchem.compound:71460273
CHEMBL2152261
pubchem.compound:71460273
9P59GES78D
pubchem.compound:71460273
n-isopentenyladenine
pubchem.compound:92180
isopentenyl-adenine
pubchem.compound:92180
ZX-AFC000343
pubchem.compound:92180
ZINC32351
pubchem.compound:92180
ZB000921
pubchem.compound:92180
V500BB256Z
pubchem.compound:92180
V0538
pubchem.compound:92180
UNII-V500BB256Z
pubchem.compound:92180
TimTec1_003281
pubchem.compound:92180
ST24048354
pubchem.compound:92180
ST044513
pubchem.compound:92180
SCHEMBL459276
pubchem.compound:92180
SC-18768
pubchem.compound:92180
Oprea1_344117
pubchem.compound:92180
NSC106958
pubchem.compound:92180
NSC-106958
pubchem.compound:92180
NSC 106958
pubchem.compound:92180
NCIStruc2_000921
pubchem.compound:92180
NCIStruc1_000935
pubchem.compound:92180
NCI60_000165
pubchem.compound:92180
NCI106958
pubchem.compound:92180
NCGC00097193-01
pubchem.compound:92180
NCGC00014084-02
pubchem.compound:92180
NCGC00014084
pubchem.compound:92180
N6-Isopentenyladenine
pubchem.compound:92180
N6-Dimethylallyladenine
pubchem.compound:92180
N6-Delta2-isopentenyladenine
pubchem.compound:92180
N6-.DELTA.2-Isopentenyl)adenine
pubchem.compound:92180
N6-(delta2-Isopentenyl)aminopurine
pubchem.compound:92180
N6-(delta2-Isopentenyl)adenine
pubchem.compound:92180
N6-(delta2-Isopentenyl)-adenine
pubchem.compound:92180
N6-(delta 2-Isopentenyl)-adenine
pubchem.compound:92180
N6-(3-Methylbut-2-enyl)adenine
pubchem.compound:92180
N6-(3-Methyl-2-butenyl)adenine
pubchem.compound:92180
N6-(2-Isopentenyl)adenine
pubchem.compound:92180
N6-(2-Isopentenyl)-adenine
pubchem.compound:92180
N6-(.DELTA.2-Isopentenyl)aminopurine
pubchem.compound:92180
N6-(.DELTA.2-Isopentenyl)adenine
pubchem.compound:92180
N6 -(Delta2 -Isopentenyl)adenine
pubchem.compound:92180
N-6-(delta2-Isopentenyl)-adenine
pubchem.compound:92180
N-6-(3,3-Dimethylallyl)adenine
pubchem.compound:92180
N-(gamma,gamma-Dimethylallyl)adenine
pubchem.compound:92180
N-(delta2-Isopentenyl)adenine
pubchem.compound:92180
N-(3-methylbut-2-enyl)-9H-purin-6-amine
pubchem.compound:92180
N-(3-methylbut-2-enyl)-7H-purin-6-amine
pubchem.compound:92180
N-(3-methylbut-2-en-1-yl)-7H-purin-6-amine
pubchem.compound:92180
N-(3-methyl-2-butenyl)-9H-purin-6-amine
pubchem.compound:92180
N-(3-Methyl-2-butenyl)adenine
pubchem.compound:92180
N-(3-Methyl-2-butenyl)-1H-purin-6-amine #
pubchem.compound:92180
N-(3-Methyl-2-butenyl)-1H-purin-6-amine
pubchem.compound:92180
N-(3-METHYLBUT-2-EN-1-YL)-9H-PURIN-6-AMINE
pubchem.compound:92180
N-(.gamma.,.gamma.-Dimethylallyl)adenine
pubchem.compound:92180
N-(.DELTA.2-Isopentenyl)adenine
pubchem.compound:92180
N(6)-dimethylallyladenine
pubchem.compound:92180
N(6)-(delta(2)-Isopentenyl)adenine
pubchem.compound:92180
N(6)-(Delta2-isopentenyl)adenine
pubchem.compound:92180
N(6)-(.DELTA.2-Isopentenyl)aminopurine
pubchem.compound:92180
MolPort-002-511-573
pubchem.compound:92180
MFCD00132998
pubchem.compound:92180
MCULE-6781114249
pubchem.compound:92180
LS-184209
pubchem.compound:92180
KB-57456
pubchem.compound:92180
Isopentenyladenine
pubchem.compound:92180
Isopentenyl adenine
pubchem.compound:92180
IPADE
pubchem.compound:92180
I14-7114
pubchem.compound:92180
HYVABZIGRDEKCD-UHFFFAOYSA-N
pubchem.compound:92180
HY-112103
pubchem.compound:92180
HMS1543F03
pubchem.compound:92180
FT-0629731
pubchem.compound:92180
Enadenine
pubchem.compound:92180
EBD28940
pubchem.compound:92180
Dimethylallyladenine
pubchem.compound:92180
DTXSID10178325
pubchem.compound:92180
DB08768
pubchem.compound:92180
D0I1SZ
pubchem.compound:92180
D-4760
pubchem.compound:92180
CTK8G1492
pubchem.compound:92180
CS-0043352
pubchem.compound:92180
CI-027
pubchem.compound:92180
CHEMBL476189
pubchem.compound:92180
CHEBI:17660
pubchem.compound:92180
CCG-38046
pubchem.compound:92180
C04083
pubchem.compound:92180
BRD-K62158429-001-01-7
pubchem.compound:92180
BID525
pubchem.compound:92180
BC209320
pubchem.compound:92180
Adenine, N-(3-methyl-2-butenyl)- (8CI)
pubchem.compound:92180
Adenine, N-(3-methyl-2-butenyl)-
pubchem.compound:92180
AX8017021
pubchem.compound:92180
AS-17517
pubchem.compound:92180
AN-50750
pubchem.compound:92180
AKOS028109417
pubchem.compound:92180
AKOS015914857
pubchem.compound:92180
AKOS005257639
pubchem.compound:92180
AK163607
pubchem.compound:92180
ACM2365404
pubchem.compound:92180
AC1L3NL1
pubchem.compound:92180
AC-15608
pubchem.compound:92180
A816825
pubchem.compound:92180
6-[(3-methylbut-2-en-1-yl)amino]purine
pubchem.compound:92180
6-[(3-Methyl-2-butenyl)amino]purine
pubchem.compound:92180
6-(|A,|A-Dimethylallylamino)purine
pubchem.compound:92180
6-(gamma,gamma-Dimethylallylamino)purine, Vetec(TM) reagent grade, >=98.5%
pubchem.compound:92180
6-(gamma,gamma-Dimethylallylamino)purine, BioReagent, plant cell culture tested, >=98.5%
pubchem.compound:92180
6-(gamma,gamma-Dimethylallylamino)purine, BioReagent, plant cell culture tested, >=90%
pubchem.compound:92180
6-(gamma,gamma-Dimethylallylamino)purine, BioReagent, plant cell culture tested, 1 mg/mL
pubchem.compound:92180
6-(gamma,gamma-Dimethylallylamino)purine
pubchem.compound:92180
6-(gamma,gamma-DIMETHYLALLYLAMINO) PURINE
pubchem.compound:92180
6-(3-methyl-2-buten-1-ylamino)purine
pubchem.compound:92180
6-(3,3-DIMETHYLALLYLAMINO)PURINE
pubchem.compound:92180
6-(.gamma.,.gamma.-Dimethylallylamino)purine
pubchem.compound:92180
6-((3-Methyl-2-butenyl)amino)purine
pubchem.compound:92180
5122-37-2
pubchem.compound:92180
365I404
pubchem.compound:92180
3-methylbut-2-enyl(7H-purin-6-yl)amine
pubchem.compound:92180
2exm
pubchem.compound:92180
2365-40-4
pubchem.compound:92180
1H-Purin-6-amine, N-(3-methyl-2-butenyl)- (9CI)
pubchem.compound:92180
1H-Purin-6-amine, N-(3-methyl-2-butenyl)-
pubchem.compound:92180
13255-47-5
pubchem.compound:92180
(3-methylbut-2-enyl)purin-6-ylamine
pubchem.compound:92180
(3-methyl-but-2-enyl)-(7(9)H-purin-6-yl)-amine
pubchem.compound:92180
isocarboxazid
pubchem.compound:3759
ZINC1587
pubchem.compound:3759
Y0484
pubchem.compound:3759
XKFPYPQQHFEXRZ-UHFFFAOYSA-N
pubchem.compound:3759
WLN: T5NOJ C1 EVMM1R
pubchem.compound:3759
UNII-34237V843T
pubchem.compound:3759
Tox21_110336
pubchem.compound:3759
TC-146958
pubchem.compound:3759
SR-01000841192-3
pubchem.compound:3759
SR-01000841192-2
pubchem.compound:3759
SR-01000841192
pubchem.compound:3759
SPBio_002869
pubchem.compound:3759
SMR001233334
pubchem.compound:3759
SCHEMBL49562
pubchem.compound:3759
Ro5-0831
pubchem.compound:3759
Ro 5-0831/1
pubchem.compound:3759
Ro 5-0831
pubchem.compound:3759
Prestwick3_000795
pubchem.compound:3759
Prestwick2_000795
pubchem.compound:3759
Prestwick1_000795
pubchem.compound:3759
Prestwick0_000795
pubchem.compound:3759
NSC169893
pubchem.compound:3759
NSC-169893
pubchem.compound:3759
NSC 169893
pubchem.compound:3759
NCGC00016267-03
pubchem.compound:3759
NCGC00016267-02
pubchem.compound:3759
NCGC00016267-01
pubchem.compound:3759
N'-benzyl-5-methyl-1,2-oxazole-3-carbohydrazide
pubchem.compound:3759
N'-Benzyl-5-methylisoxazole-3-carbohydrazide
pubchem.compound:3759
N'-Benzyl-5-methyl-3-isoxazolecarbohydrazide #
pubchem.compound:3759
N'-Benzyl N-methyl-5-isoxazolecarboxylhydrazide-3
pubchem.compound:3759
Marplon
pubchem.compound:3759
Marplan (TN)
pubchem.compound:3759
Marplan
pubchem.compound:3759
Maraplan
pubchem.compound:3759
MLS003106729
pubchem.compound:3759
MLS002154005
pubchem.compound:3759
LS-86607
pubchem.compound:3759
KB-258619
pubchem.compound:3759
Isocarboxyzid
pubchem.compound:3759
Isocarboxizid
pubchem.compound:3759
Isocarboxazidum [INN-Latin]
pubchem.compound:3759
Isocarboxazidum
pubchem.compound:3759
Isocarboxazide [INN-French]
pubchem.compound:3759
Isocarboxazide
pubchem.compound:3759
Isocarboxazida [INN-Spanish]
pubchem.compound:3759
Isocarboxazida
pubchem.compound:3759
Isocarboxazid [USP:INN:BAN]
pubchem.compound:3759
Isocarboxazid [INN:BAN]
pubchem.compound:3759
Isocarboxazid 5-methyl-3-isoxazole-carboxylic acid 2-benzylhydrazide, AldrichCPR
pubchem.compound:3759
Isocarboxazid (INN)
pubchem.compound:3759
Isocarboxazid (ICD)
pubchem.compound:3759
Isocarbossazide [DCIT]
pubchem.compound:3759
Isocarbossazide
pubchem.compound:3759
Isocarbonazid
pubchem.compound:3759
ISOCARBOXAZID (200 MG)
pubchem.compound:3759
HY-13929
pubchem.compound:3759
HMS3714O12
pubchem.compound:3759
HMS3369G18
pubchem.compound:3759
HMS2230E11
pubchem.compound:3759
HMS2097O12
pubchem.compound:3759
HMS1570O12
pubchem.compound:3759
GTPL7204
pubchem.compound:3759
FT-0670438
pubchem.compound:3759
FCH2716017
pubchem.compound:3759
Enerzer
pubchem.compound:3759
EINECS 200-438-4
pubchem.compound:3759
DTXSID4023171
pubchem.compound:3759
DSSTox_RID_76902
pubchem.compound:3759
DSSTox_GSID_23171
pubchem.compound:3759
DSSTox_CID_3171
pubchem.compound:3759
DB01247
pubchem.compound:3759
D0I2VK
pubchem.compound:3759
D02580
pubchem.compound:3759
CTK8B7692
pubchem.compound:3759
CS-0008613
pubchem.compound:3759
CHEMBL1201168
pubchem.compound:3759
CHEBI:93635
pubchem.compound:3759
CCRIS 9178
pubchem.compound:3759
CCG-220795
pubchem.compound:3759
CAS-59-63-2
pubchem.compound:3759
Benazide
pubchem.compound:3759
BSPBio_000930
pubchem.compound:3759
BRN 0201295
pubchem.compound:3759
BRD-K93332168-001-03-2
pubchem.compound:3759
BPBio1_001024
pubchem.compound:3759
BMIH
pubchem.compound:3759
BDBM163692
pubchem.compound:3759
BC645218
pubchem.compound:3759
AX8135097
pubchem.compound:3759
API0000611
pubchem.compound:3759
ANW-58213
pubchem.compound:3759
AKOS016003091
pubchem.compound:3759
AJ-08053
pubchem.compound:3759
AC1L1GNE
pubchem.compound:3759
AC-24841
pubchem.compound:3759
AB00513923
pubchem.compound:3759
59-63-2
pubchem.compound:3759
5-methyl-N'-(phenylmethyl)isoxazole-3-carbohydrazide
pubchem.compound:3759
5-methyl-N'-(phenylmethyl)-3-isoxazolecarbohydrazide
pubchem.compound:3759
5-Methyl-3-isoxazolecarboxylic acid 2-benzylhydrazide
pubchem.compound:3759
4-27-00-03999 (Beilstein Handbook Reference)
pubchem.compound:3759
34237V843T
pubchem.compound:3759
3-Isoxazolecarboxylic acid, 5-methyl-, 2-benzylhydrazide
pubchem.compound:3759
3-Isoxazolecarboxylic acid, 5-methyl-, 2-(phenylmethyl)hydrazide
pubchem.compound:3759
3-Isoxazolecarboxylic acid, 2-benzylhydrazide
pubchem.compound:3759
3-Isoxazolecarboxylic acid, 2-(phenylmethyl)hydrazide
pubchem.compound:3759
3-(2-BENZYLHYDRAZOCARBOXY)-5-METHYL-ISOXAZOLE
pubchem.compound:3759
1-Benzyl-2-(5-methyl-3-isoxazolylcarbonyl)hydrazine
pubchem.compound:3759
1-Benzyl-2-(5-methyl-3-isoxazolyl-carbonyl)hydrazine
pubchem.compound:3759
s7213
pubchem.compound:24808478
ZINC16052637
pubchem.compound:24808478
W-200641
pubchem.compound:24808478
Thiamet-G
pubchem.compound:24808478
Thiamet G;\n2-(ethylamino)-3aR,6S,7R,7aR-tetrahydro-5R-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol
pubchem.compound:24808478
Thiamet G, >=98% (HPLC)
pubchem.compound:24808478
Thiamet G
pubchem.compound:24808478
SW219118-1
pubchem.compound:24808478
SR-01000946377-1
pubchem.compound:24808478
SR-01000946377
pubchem.compound:24808478
NCGC00344096-03
pubchem.compound:24808478
MFCD15144964
pubchem.compound:24808478
J-000295
pubchem.compound:24808478
HY-12588
pubchem.compound:24808478
HMS3648I18
pubchem.compound:24808478
EX-A2240
pubchem.compound:24808478
C9H16N2O4S
pubchem.compound:24808478
AOB5913
pubchem.compound:24808478
AKOS024458135
pubchem.compound:24808478
ACN-038039
pubchem.compound:24808478
5H-Pyrano[3,2-d]thiazole-6,7-diol, 2-(ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-, (3aR,5R,6S,7R,7aR)-
pubchem.compound:24808478
2754AH
pubchem.compound:24808478
2070AH
pubchem.compound:24808478
1009816-48-1
pubchem.compound:24808478
1,2-Dideoxy-2'-ethylamino-a-D-glucopyranoso-[2,1-d]-2'-thiazoline
pubchem.compound:24808478
(3aR,5R,6S,7R,7aR)-2-(ethylamino)-5-(hydroxymethyl)-3aH,5H,6H,7H,7aH-pyrano[3,2-d][1,3]thiazole-6,7-diol
pubchem.compound:24808478
(3aR,5R,6S,7R,7aR)-2-(ethylamino)-5-(hydroxymethyl)-3a,6,7,7a-tetrahydro-5H-pyrano[3,2-d]thiazole-6,7-diol
pubchem.compound:24808478
(3aR,5R,6S,7R,7aR)-2-(Ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol
pubchem.compound:24808478
(3aR)-2-(Ethylamino)-6beta,7alpha-dihydroxy-3aalpha,6,7,7aalpha-tetrahydro-5H-pyrano[3,2-d]thiazole-5alpha-methanol
pubchem.compound:24808478
Thioacetic acid S-[(S)-6-[[(R)-5-oxopyrrolidine-2-ylcarbonyl]amino]-6-(phenylcarbamoyl)hexyl] ester
pubchem.compound:71538210
ST-7612AA1
pubchem.compound:71538210
SCHEMBL14812001
pubchem.compound:71538210
SB17083
pubchem.compound:71538210
CHEMBL3353926
pubchem.compound:71538210
BDBM50027652
pubchem.compound:71538210
A14418
pubchem.compound:71538210
1428535-92-5
pubchem.compound:71538210
s1066
pubchem.compound:9549284
alpha-{amino[(4-aminophenyl)thio]methylene}-2-(trifluoromethyl)benzeneacetonitrile
pubchem.compound:9549284
alpha-[Amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile
pubchem.compound:9549284
ZINC1910234
pubchem.compound:9549284
Z-& E-alpha-(Amino-((4-aminophenyl)thio)methylene)-2-(trifluoromethyl)benzeneacetonitrile
pubchem.compound:9549284
Z-& E-a-(Amino-((4-aminophenyl)thio)methylene)-2-(trifluoromethyl)benzeneacetonitrile
pubchem.compound:9549284
X3440
pubchem.compound:9549284
W-5333
pubchem.compound:9549284
SW219839-1
pubchem.compound:9549284
SL327, >=98% (HPLC), Mixture of E & Z isomers, solid
pubchem.compound:9549284
SL327
pubchem.compound:9549284
SL-327
pubchem.compound:9549284
SL 327
pubchem.compound:9549284
SCHEMBL570318
pubchem.compound:9549284
SCHEMBL570317
pubchem.compound:9549284
SB19419
pubchem.compound:9549284
NCGC00092290-02
pubchem.compound:9549284
NCGC00092290-01
pubchem.compound:9549284
MolPort-006-069-021
pubchem.compound:9549284
MFCD06411432
pubchem.compound:9549284
MEK1/2 Inhibitor
orcid:0000-0001-9439-5346
LS-193345
pubchem.compound:9549284
KB-80585
pubchem.compound:9549284
K00090
pubchem.compound:9549284
JLOXTZFYJNCPIS-FYWRMAATSA-N
pubchem.compound:9549284
J-018001
pubchem.compound:9549284
HY-15437
pubchem.compound:9549284
HSCI1_000044
pubchem.compound:9549284
HMS3678M21
pubchem.compound:9549284
HMS3229K18
pubchem.compound:9549284
GTPL6008
pubchem.compound:9549284
EX-A1069
pubchem.compound:9549284
EC-000.2354
pubchem.compound:9549284
E/Z-a-[amino[(4-aminophenyl)thio]methylen]-2-(trifluoromethyl)benzeneacetonitrile
pubchem.compound:9549284
DTXSID90429549
pubchem.compound:9549284
D04WPA
pubchem.compound:9549284
CS-0910
pubchem.compound:9549284
CHEBI:92211
pubchem.compound:9549284
CCG-206867
pubchem.compound:9549284
Benzeneacetonitrile, alpha-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)-
pubchem.compound:9549284
BRD-K12244279-001-01-7
pubchem.compound:9549284
BCP05310
pubchem.compound:9549284
BC600460
pubchem.compound:9549284
AOB5954
pubchem.compound:9549284
AKOS024456884
pubchem.compound:9549284
305350-87-2
pubchem.compound:9549284
3-amino-3-[(4-aminophenyl)thio]-2-[2-(trifluoromethyl)phenyl]-2-propenenitrile
pubchem.compound:9549284
3-amino-3-[(4-aminophenyl)sulfanyl]-2-[2-(trifluoromethyl)phenyl]acrylonitrile
pubchem.compound:9549284
3-amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile
pubchem.compound:9549284
(Z)-3-amino-3-(4-aminophenylthio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile
pubchem.compound:9549284
(2Z)-3-amino-3-[(4-aminophenyl)sulfanyl]-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile
pubchem.compound:9549284
s7229
pubchem.compound:56650312
ZINC95616594
pubchem.compound:56650312
SW219401-1
pubchem.compound:56650312
SCHEMBL12497871
pubchem.compound:56650312
SCHEMBL12497867
pubchem.compound:56650312
SB19284
pubchem.compound:56650312
RGFP966, >=98% (HPLC)
pubchem.compound:56650312
RGFP966 Racemate
pubchem.compound:56650312
RGFP966
pubchem.compound:56650312
RGFP-966
pubchem.compound:56650312
RGFP 966
pubchem.compound:56650312
QC-11774
pubchem.compound:56650312
MolPort-035-395-807
pubchem.compound:56650312
MFCD26960954
pubchem.compound:56650312
KB-148638
pubchem.compound:56650312
J-007305
pubchem.compound:56650312
GTPL7500
pubchem.compound:56650312
EX-A229
pubchem.compound:56650312
DA-45706
pubchem.compound:56650312
DA-45384
pubchem.compound:56650312
D00HXX
pubchem.compound:56650312
CHEMBL4078477
pubchem.compound:56650312
CHEBI:131163
pubchem.compound:56650312
C21H19FN4O
pubchem.compound:56650312
BLVQHYHDYFTPDV-VCABWLAWSA-N
pubchem.compound:56650312
BCP08102
pubchem.compound:56650312
BC600495
pubchem.compound:56650312
AKOS030526449
pubchem.compound:56650312
AK676067
pubchem.compound:56650312
A13218
pubchem.compound:56650312
2686AH
pubchem.compound:56650312
2-Propenamide, N-(2-amino-4-fluorophenyl)-3-[1-[(2E)-3-phenyl-2-propen-1-yl]-1H-pyrazol-4-yl]-, (2E)-
pubchem.compound:56650312
1396841-57-8
pubchem.compound:56650312
1357389-11-7
pubchem.compound:56650312
(E)-N-(2-amino-4-fluorophenyl)-3-(1-cinnamyl-1H-pyrazol-4-yl)acrylamide
pubchem.compound:56650312
(2E)-N-(2-amino-4-fluorophenyl)-3-{1-[(2E)-3-phenylprop-2-en-1-yl]-1H-pyrazol-4-yl}prop-2-enamide
pubchem.compound:56650312
ldn-193594
pubchem.compound:54581340
ZINC71317068
pubchem.compound:54581340
XHJMMMPXTUEBMQ-UHFFFAOYSA-N
pubchem.compound:54581340
NSC747885
pubchem.compound:54581340
NSC-747885
pubchem.compound:54581340
KB-274259
pubchem.compound:54581340
CHEMBL1761791
pubchem.compound:54581340
BDBM50340902
pubchem.compound:54581340
1289638-15-8
pubchem.compound:54581340
(4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(2-fluorophenyl)methanone
pubchem.compound:54581340
ZINC38760485
pubchem.compound:10397232
SCHEMBL793684
pubchem.compound:10397232
MolPort-019-997-392
pubchem.compound:10397232
MFCD06208438
pubchem.compound:10397232
MCULE-2720405682
pubchem.compound:10397232
KB-106928
pubchem.compound:10397232
K-8942
pubchem.compound:10397232
IGZSSKAOSOCVPH-UHFFFAOYSA-N
pubchem.compound:10397232
FT-0718529
pubchem.compound:10397232
F9995-2550
pubchem.compound:10397232
DTXSID30439182
pubchem.compound:10397232
DB-070534
pubchem.compound:10397232
CTK4I8112
pubchem.compound:10397232
CM-414
pubchem.compound:10397232
AKOS010054622
pubchem.compound:10397232
AJ-96850
pubchem.compound:10397232
AB1552
pubchem.compound:10397232
AB0085720
pubchem.compound:10397232
A826542
pubchem.compound:10397232
4868AH
pubchem.compound:10397232
4432-44-4
pubchem.compound:10397232
4-Morpholinepropanoicacid, a-methylene-
pubchem.compound:10397232
2-morpholin-4ylmethyl-2-propenoic acid
pubchem.compound:10397232
2-morpholin-4-ylmethyl-2-propenoic acid
pubchem.compound:10397232
2-[(morpholin-4-yl)methyl]prop-2-enoic acid
pubchem.compound:10397232
2-Morpholin4-ylmethyl-acrylic acid
pubchem.compound:10397232
2-MORPHOLIN-4-YLMETHYL-ACRYLIC ACID
pubchem.compound:10397232
2-(morpholin-4-ylmethyl)prop-2-enoic Acid
pubchem.compound:10397232
2-(Morpholinomethyl)propenoic acid
pubchem.compound:10397232
2-(Morpholinomethyl)acrylic acid
pubchem.compound:10397232
2-(4-morpholinylmethyl)-2-propenoic acid
pubchem.compound:10397232
dibenzo-(b,f)oxepin-10-ylmethyl-methyl-prop-2-ynyl-amine
pubchem.compound:6419718
dibenz[b,f]oxepin-10-ylmethyl-N-methyl-N-prop-2-ynylamine
pubchem.compound:6419718
ZINC33943510
pubchem.compound:6419718
UNII-5V14HD0N4Q
pubchem.compound:6419718
Tch 346
pubchem.compound:6419718
TCH346
pubchem.compound:6419718
TCH-346B
pubchem.compound:6419718
TCH-346
pubchem.compound:6419718
SNT-317
pubchem.compound:6419718
SCHEMBL333032
pubchem.compound:6419718
QLMMOGWZCFQAPU-UHFFFAOYSA-N
pubchem.compound:6419718
Omigapil)
pubchem.compound:6419718
Omigapil [INN]
pubchem.compound:6419718
Omigapil
pubchem.compound:6419718
Nootropicagent, Santhera
pubchem.compound:6419718
Nootropic agent, Novartis
pubchem.compound:6419718
Neuroprotectant, Santhera
pubchem.compound:6419718
Neuroprotectant, Novartis
pubchem.compound:6419718
NCGC00346431-01
pubchem.compound:6419718
N-(dibenzo[b,f]oxepin-10-ylmethyl)-N-methylprop-2-yn-1-amine
pubchem.compound:6419718
N-(benzo[b][1]benzoxepin-5-ylmethyl)-N-methylprop-2-yn-1-amine
pubchem.compound:6419718
N-(DIBENZO[B,F]OXEPIN-10-YLMETHYL)-N-METHYL-N-PROP-2-YNYLAMINE
pubchem.compound:6419718
Dibenzo(b,f)oxepin-10-ylmethyl-methyl-prop-2-ynylamine
pubchem.compound:6419718
DTXSID10171098
pubchem.compound:6419718
DB12879
pubchem.compound:6419718
D06KSV
pubchem.compound:6419718
CHEMBL1232111
pubchem.compound:6419718
CHEBI:41778
pubchem.compound:6419718
CGP-3499B
pubchem.compound:6419718
CGP-3466
pubchem.compound:6419718
CGP 3466
pubchem.compound:6419718
AC1O4WBX
pubchem.compound:6419718
634202-78-1
pubchem.compound:6419718
5V14HD0N4Q
pubchem.compound:6419718
181296-84-4
pubchem.compound:6419718
(Dibenzo(b,f)oxepin-5-ylmethyl)(methyl)prop-2-yn-1-amine
pubchem.compound:6419718
ZINC13838357
pubchem.compound:1285940
STK219801
pubchem.compound:1285940
SCHEMBL14991291
pubchem.compound:1285940
MolPort-002-976-806
pubchem.compound:1285940
KB-145969
pubchem.compound:1285940
HY-13823
pubchem.compound:1285940
EX-A1063
pubchem.compound:1285940
CS-3529
pubchem.compound:1285940
CHEMBL3734823
pubchem.compound:1285940
C646
pubchem.compound:1285940
C-646
pubchem.compound:1285940
C 646
pubchem.compound:1285940
BRD-K68548958-001-01-2
pubchem.compound:1285940
BC600370
pubchem.compound:1285940
AOB5549
pubchem.compound:1285940
AKOS005418912
pubchem.compound:1285940
AC1LPE4S
pubchem.compound:1285940
4-[(4E)-4-{[5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl]methylidene}-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid
pubchem.compound:1285940
4-[(4E)-4-[[5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
pubchem.compound:1285940
4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
pubchem.compound:1285940
328968-36-1
pubchem.compound:1285940
(E)-4-(4-((5-(4,5-diMethyl-2-nitrophenyl)furan-2-yl)Methylene)-3-Methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
pubchem.compound:1285940
cc-526
pubchem.compound:10200390
ZINC3817793
pubchem.compound:10200390
UNII-61G8S0H9KX
pubchem.compound:10200390
Syk inhibitor IV
pubchem.compound:10200390
SCHEMBL373774
pubchem.compound:10200390
RL04784
pubchem.compound:10200390
NCGC00346945-06
pubchem.compound:10200390
NCGC00346945-01
pubchem.compound:10200390
Kinome_3125
pubchem.compound:10200390
KB-74859
pubchem.compound:10200390
J-507625
pubchem.compound:10200390
HY-76474
pubchem.compound:10200390
GTPL9693
pubchem.compound:10200390
EX-A1437
pubchem.compound:10200390
CS-0235
pubchem.compound:10200390
CHEMBL1242100
pubchem.compound:10200390
CHEMBL1190711
pubchem.compound:10200390
CHEBI:91426
pubchem.compound:10200390
CCG-102604
pubchem.compound:10200390
BRD-K53281329-001-01-9
pubchem.compound:10200390
BDBM50325991
pubchem.compound:10200390
BCP08946
pubchem.compound:10200390
BAY61-3606
pubchem.compound:10200390
BAY-613606
pubchem.compound:10200390
BAY-61-3606 free base
pubchem.compound:10200390
BAY-61-360
pubchem.compound:10200390
BAY 61-3606 HCl
pubchem.compound:10200390
BAY 61-3606
pubchem.compound:10200390
AKOS030526888
pubchem.compound:10200390
ACN-053214
pubchem.compound:10200390
AC-29888
pubchem.compound:10200390
A11320
pubchem.compound:10200390
732983-37-8
pubchem.compound:10200390
61G8S0H9KX
pubchem.compound:10200390
3-Pyridinecarboxamide, 2-((7-(3,4-dimethoxyphenyl)imidazo(1,2-C)pyrimidin-5-yl)amino)-
pubchem.compound:10200390
2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide
pubchem.compound:10200390
2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidine-5-yl]amino]-3-pyridinecarboxamide
pubchem.compound:10200390
2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide
pubchem.compound:10200390
2-(7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-ylamino)nicotinamide hydrochloride
pubchem.compound:10200390
2-((7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl)amino)nicotinamide
pubchem.compound:10200390
s8001
pubchem.compound:53340666
rocilinostat-acy-1215
pubchem.compound:53340666
ZINC89630354
pubchem.compound:53340666
X5832
pubchem.compound:53340666
WKT909C62B
pubchem.compound:53340666
W-5979
pubchem.compound:53340666
US8609678, 2-(diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide [26]
pubchem.compound:53340666
UNII-WKT909C62B
pubchem.compound:53340666
SW219836-1
pubchem.compound:53340666
ST24039648
pubchem.compound:53340666
SMR004702950
pubchem.compound:53340666
SCHEMBL574580
pubchem.compound:53340666
SB17054
pubchem.compound:53340666
Rocilinostat (ACY-1215)
pubchem.compound:53340666
Rocilinostat
pubchem.compound:53340666
Ricolinostat [USAN:INN]
pubchem.compound:53340666
Ricolinostat (USAN/INN)
pubchem.compound:53340666
Ricolinostat (ACY-1215)
pubchem.compound:53340666
Ricolinostat
pubchem.compound:53340666
NCGC00345802-05
pubchem.compound:53340666
NCGC00345802-01
pubchem.compound:53340666
N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)pyrimidine-5-carboxamide
pubchem.compound:53340666
MolPort-028-600-031
pubchem.compound:53340666
MLS006011181
pubchem.compound:53340666
MFCD22666356
pubchem.compound:53340666
KS-00000SAV
pubchem.compound:53340666
KB-74507
pubchem.compound:53340666
J-690127
pubchem.compound:53340666
HY-16026
pubchem.compound:53340666
HMS3653F17
pubchem.compound:53340666
GTPL7010
pubchem.compound:53340666
EX-A139
pubchem.compound:53340666
DTXSID40157148
pubchem.compound:53340666
DB12376
pubchem.compound:53340666
D10661
pubchem.compound:53340666
D0TP9M
pubchem.compound:53340666
CS-0965
pubchem.compound:53340666
CHEMBL2364628
pubchem.compound:53340666
CHEBI:95073
pubchem.compound:53340666
BDBM50439674
pubchem.compound:53340666
BCP06028
pubchem.compound:53340666
BC600387
pubchem.compound:53340666
AX8288032
pubchem.compound:53340666
AKOS024259260
pubchem.compound:53340666
AK151416
pubchem.compound:53340666
AJ-128539
pubchem.compound:53340666
AH4
pubchem.compound:53340666
ACY1215
pubchem.compound:53340666
ACY-63
pubchem.compound:53340666
ACY-1215
pubchem.compound:53340666
ACN-030031
pubchem.compound:53340666
AC-30258
pubchem.compound:53340666
AB0032517
pubchem.compound:53340666
A11940
pubchem.compound:53340666
7-{[2-(DIPHENYLAMINO)PYRIMIDIN-5-YL]FORMAMIDO}-N-HYDROXYHEPTANAMIDE
pubchem.compound:53340666
5-Pyrimidinecarboxamide, 2-(diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-
pubchem.compound:53340666
5-Pyrimidinecarboxamide, 2-(diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)-
pubchem.compound:53340666
2-(diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]pyrimidine-5-carboxamide
pubchem.compound:53340666
2-(Diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide
pubchem.compound:53340666
2-(Diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide
pubchem.compound:53340666
1316214-52-4
pubchem.compound:53340666
bromohexadecanoic acid
pubchem.compound:82145
alpha-Bromopalmitic acid
pubchem.compound:82145
ZX-AT022731
pubchem.compound:82145
VZ24096
pubchem.compound:82145
Tox21_301033
pubchem.compound:82145
TRA0083226
pubchem.compound:82145
TC-170832
pubchem.compound:82145
ST45026694
pubchem.compound:82145
SCHEMBL97565
pubchem.compound:82145
SBB071635
pubchem.compound:82145
OR10833
pubchem.compound:82145
NSC58378
pubchem.compound:82145
NSC-58378
pubchem.compound:82145
NSC 58378
pubchem.compound:82145
NCIOpen2_007723
pubchem.compound:82145
NCGC00254935-01
pubchem.compound:82145
NCGC00164251-02
pubchem.compound:82145
NCGC00164251-01
pubchem.compound:82145
MolPort-001-759-724
pubchem.compound:82145
MFCD00004215
pubchem.compound:82145
MCULE-7613431163
pubchem.compound:82145
LS-174823
pubchem.compound:82145
LMFA01090011
pubchem.compound:82145
L213
pubchem.compound:82145
KB-68336
pubchem.compound:82145
J-011689
pubchem.compound:82145
I04-8986
pubchem.compound:82145
Hexadecanoic acid,2-bromo-
pubchem.compound:82145
Hexadecanoic acid, 2-bromo-
pubchem.compound:82145
FT-0611564
pubchem.compound:82145
EINECS 242-137-0
pubchem.compound:82145
DTXSID0037734
pubchem.compound:82145
DSSTox_RID_79368
pubchem.compound:82145
DSSTox_GSID_37734
pubchem.compound:82145
DSSTox_CID_17734
pubchem.compound:82145
DPRAYRYQQAXQPE-UHFFFAOYSA-N
pubchem.compound:82145
DB-044471
pubchem.compound:82145
CTK4D8252
pubchem.compound:82145
CHEMBL118417
pubchem.compound:82145
CHEBI:133152
pubchem.compound:82145
CC-09685
pubchem.compound:82145
CAS-18263-25-7
pubchem.compound:82145
C16H31BrO2
pubchem.compound:82145
C-20189
pubchem.compound:82145
BDBM50148454
pubchem.compound:82145
AKOS017343270
pubchem.compound:82145
AKOS003404931
pubchem.compound:82145
ACMC-1C7OL
pubchem.compound:82145
ACM18263257
pubchem.compound:82145
AC1Q2444
pubchem.compound:82145
AC1L32UD
pubchem.compound:82145
A812715
pubchem.compound:82145
40305-76-8
pubchem.compound:82145
2-bromopalmitate, (+-)-isomer
pubchem.compound:82145
2-bromo-hexadecanoic acid
pubchem.compound:82145
2-bromanylhexadecanoic acid
pubchem.compound:82145
2-Bromopalmitic acid
pubchem.compound:82145
2-Bromopalmitate
pubchem.compound:82145
2-Bromohexadecanoic acid, ~97%
pubchem.compound:82145
2-Bromohexadecanoic acid, purum, >=97.0% (GC)
pubchem.compound:82145
2-Bromohexadecanoic acid, >=99.0% (GC)
pubchem.compound:82145
2-Bromohexadecanoic acid
pubchem.compound:82145
18263-25-7
pubchem.compound:82145
.alpha.-Bromopalmitic acid
pubchem.compound:82145
ethyl 4-(2-benzamidoethylamino)piperidine-1-carboxylate hydrochloride
pubchem.compound:25010774
VU0184670
pubchem.compound:25010774
SMR001318088
pubchem.compound:25010774
MLS002279950
pubchem.compound:25010774
CHEMBL1535797
pubchem.compound:25010774
1135241-95-0
pubchem.compound:25010774
cyclopentyl 3,4-dimethyl-6-(6-nitro-1,3-benzodioxol-5-yl)-2-oxo-1,6-dihydropyrimidine-5-carboxylate
pubchem.compound:2882724
cyclopentyl 1,6-dimethyl-4-(6-nitrobenzo[d][1,3]-dioxol-5-yl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
pubchem.compound:2882724
cyclopentyl 1,6-dimethyl-4-(6-nitrobenzo[d][1,3]-dioxol-5-yl)-2-oxo-1,2,3,4 tetrahydropyrimidine-5-carboxylate
pubchem.compound:2882724
cyclopentyl 1,6-dimethyl-4-(6-nitro-1,3-benzodioxol-5-yl)-2-oxo-3,4-dihydropyrimidine-5-carboxylate
pubchem.compound:2882724
cyclopentyl 1,6-dimethyl-4-(6-nitro-1,3-benzodioxol-5-yl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
pubchem.compound:2882724
VU0090157
pubchem.compound:2882724
UNM000000551301
pubchem.compound:2882724
STK079398
pubchem.compound:2882724
SR-01000433423-1
pubchem.compound:2882724
SR-01000433423
pubchem.compound:2882724
Oprea1_103541
pubchem.compound:2882724
MolPort-002-181-662
pubchem.compound:2882724
MCULE-4339280714
pubchem.compound:2882724
GTPL3259
pubchem.compound:2882724
EU-0038260
pubchem.compound:2882724
D0O6BD
pubchem.compound:2882724
CBMicro_042727
pubchem.compound:2882724
BIM-0042576.P001
pubchem.compound:2882724
AKOS022078796
pubchem.compound:2882724
AKOS001633711
pubchem.compound:2882724
AC1MER3E
pubchem.compound:2882724
ZINC38534584
pubchem.compound:6758210
ZINC1204219
pubchem.compound:6758210
KS-000046FP
pubchem.compound:6758210
D0L5AG
pubchem.compound:6758210
BCP17383
pubchem.compound:6758210
AOB2484
pubchem.compound:6758210
AKOS028114549
pubchem.compound:6758210
326001-01-8
pubchem.compound:6758210
2-[(4-ethoxyphenyl)amino]-N'-[(2-hydroxy-1-naphthyl)methylene]acetohydrazide (non-preferred name)
pubchem.compound:6758210
2-(4-ethoxyanilino)-N'-[(E)-(2-oxonaphthalen-1-ylidene)methyl]acetohydrazide
pubchem.compound:6758210
cid_1541501
pubchem.compound:1541501
ZINC1472126
pubchem.compound:1541501
VU0152099-1
pubchem.compound:1541501
VU0152099
pubchem.compound:1541501
STK207844
pubchem.compound:1541501
SMR001398665
pubchem.compound:1541501
Oprea1_621562
pubchem.compound:1541501
MolPort-000-437-290
pubchem.compound:1541501
MLS002474500
pubchem.compound:1541501
MCULE-6171593814
pubchem.compound:1541501
HMS3843E06
pubchem.compound:1541501
GTPL3256
pubchem.compound:1541501
D0Y1VB
pubchem.compound:1541501
BDBM48044
pubchem.compound:1541501
AKOS002170228
pubchem.compound:1541501
AC1Q2P5R
pubchem.compound:1541501
AC1LTW64
pubchem.compound:1541501
612514-42-8
pubchem.compound:1541501
3-azanyl-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxamide
pubchem.compound:1541501
3-amino-N-(benzo[d][1,3]dioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine carboxamide
pubchem.compound:1541501
3-amino-N-(2H-1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
pubchem.compound:1541501
3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[5,4-b]pyridine-2-carboxamide
pubchem.compound:1541501
3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
pubchem.compound:1541501
3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethyl-2-thieno[2,3-b]pyridinecarboxamide
pubchem.compound:1541501
3-amino-4,6-dimethyl-N-piperonyl-thieno[2,3-b]pyridine-2-carboxamide
pubchem.compound:1541501
VU0456940
https://medkoo.com/products/9998
VU-0456940
https://medkoo.com/products/9998
VU 0456940
https://medkoo.com/products/9998
f-LIGRLO-NH2
pubchem.compound:714286
cid_714286
pubchem.compound:714286
ZINC109066
pubchem.compound:714286
VU10010
pubchem.compound:714286
VU0402469-1
pubchem.compound:714286
VU-10010
pubchem.compound:714286
VU 10010
pubchem.compound:714286
STL227650
pubchem.compound:714286
SR-01000147542-1
pubchem.compound:714286
SR-01000147542
pubchem.compound:714286
SMR001398666
pubchem.compound:714286
RT-016241
pubchem.compound:714286
NCGC00378784-01
pubchem.compound:714286
MolPort-002-722-568
pubchem.compound:714286
MLS002474501
pubchem.compound:714286
MCULE-8947006791
pubchem.compound:714286
KB-81468
pubchem.compound:714286
HMS3431D09
pubchem.compound:714286
FPRULFHDSFKYBV-UHFFFAOYSA-N
pubchem.compound:714286
DTXSID30351931
pubchem.compound:714286
D0N2VN
pubchem.compound:714286
CTK5B8654
pubchem.compound:714286
CHEMBL1212994
pubchem.compound:714286
BDBM50323691
pubchem.compound:714286
B7285
pubchem.compound:714286
AKOS000282930
pubchem.compound:714286
AC1LEM0C
pubchem.compound:714286
A3274/0139289
pubchem.compound:714286
633283-39-3
pubchem.compound:714286
3-amino-N-[(4-chlorophenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
pubchem.compound:714286
3-amino-N-(4-chlorobenzyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
pubchem.compound:714286
3-Amino-N-(4-chlorobenzyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide 2,2,2-trifluoroacetate
pubchem.compound:714286
2fLI
pubchem.compound:714286
2-fAP
pubchem.compound:714286
2-f-LIGRLO-NH2
pubchem.compound:714286
2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2 trifluoroacetate salt
pubchem.compound:714286
2-Furoyl-LIGRLO-amide trifluoroacetate salt, >=97% (HPLC)
pubchem.compound:714286
2-Furoyl-LIGRLO-amide trifluoroacetate salt
pubchem.compound:714286
2-Fly
pubchem.compound:714286
PRD
pubmed:26789759
P domain
pubmed:8068626
SEC-R
?
microtubule-associated protein tau isoform 5
?
htau34
pubmed:22762014
1N4R
?
microtubule-associated protein tau isoform 8
?
htau39
pubmed:22762014
2N3R
?
microtubule-associated protein tau isoform 3
?
htau24
pubmed:22762014
0N4R
?
microtubule-associated protein tau isoform 7
?
htau37
pubmed:22762014
1N3R
?
microtubule-associated protein tau isoform 4
?
htau23
pubmed:7667312
0N3R
?
microtubule-associated protein tau isoform 2
?
htau40
pubmed:19226187
2N4R
?
MAP2/Tau projection
?
PHF6
pubmed:25775228
PHF6*
pubmed:25775228
soluble amyloid precursor protein
?
YENPTY
?
GVD
?
AGD
?
[Pro3]-GIP (Rat)
pubchem.compound:131954578
AKOS034831571
pubchem.compound:131954578
ADDL
pubmed:16712494
ZINC97971833
pubchem.compound:16394575
UNII-9BU4T267E4
pubchem.compound:16394575
Spirost-5-en-3-ol, 3-hexanoate, (3beta,25R)-
pubchem.compound:16394575
SP-233
pubchem.compound:16394575
SP-223
pubchem.compound:16394575
MolPort-002-507-344
pubchem.compound:16394575
MCULE-6852340934
pubchem.compound:16394575
J2.343.184J
pubchem.compound:16394575
Diosgenin, hexanoate
pubchem.compound:16394575
Diosgenin caproate
pubchem.compound:16394575
DB05263
pubchem.compound:16394575
CAPROSPINOL
pubchem.compound:16394575
AKOS015955746
pubchem.compound:16394575
9BU4T267E4
pubchem.compound:16394575
4952-56-1
pubchem.compound:16394575
(3beta,8xi,9xi,14xi,16xi,17xi,20R,22xi,25R)-Spirost-5-en-3-yl hexanoa
pubchem.compound:16394575
(22R,25R)-20alpha-Spirost-5-en-3beta-yl hexanoate
pubchem.compound:16394575
((20S,22R,25R)-Spirosta-5-ene-3beta-ol)hexanoate
pubchem.compound:16394575
ethyl 5-amino-4-oxo-3-phenylthieno[3,4-d]pyridazine-1-carboxylate
pubchem.compound:647821
ethyl 5-amino-4-oxo-3-phenyl-3H,4H-thieno[3,4-d]pyridazine-1-carboxylate
pubchem.compound:647821
ethyl 5-amino-4-oxo-3-phenyl-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate
pubchem.compound:647821
ZINC563211
pubchem.compound:647821
SMR000013604
pubchem.compound:647821
SCHEMBL7885074
pubchem.compound:647821
NCGC00031883-02
pubchem.compound:647821
MolPort-001-835-700
pubchem.compound:647821
MLS002539346
pubchem.compound:647821
MLS000034832
pubchem.compound:647821
MCULE-6208802152
pubchem.compound:647821
L-4233
pubchem.compound:647821
HMS2339G13
pubchem.compound:647821
HMS1616C21
pubchem.compound:647821
HLVGVGCIJRBRQW-UHFFFAOYSA-N
pubchem.compound:647821
F2135-0238
pubchem.compound:647821
CHEMBL461431
pubchem.compound:647821
CCG-115473
pubchem.compound:647821
BDBM50253793
pubchem.compound:647821
BAS 06046551
pubchem.compound:647821
AKOS000601368
pubchem.compound:647821
AC1Q34EJ
pubchem.compound:647821
AC1LDGR2
pubchem.compound:647821
5-Amino-4-oxo-3-phenyl-3,4-dihydro-thieno[3,4-d]pyridazine-1-carboxylic acid ethyl ester
pubchem.compound:647821
5-Amino-4-oxo-3-phenyl-3,4-dihydro-thieno[3,4-d]pyridazine-1-carboxylic acid eth
pubchem.compound:647821
3-Phenyl-4-oxo-5-amino-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylic acid ethyl ester
pubchem.compound:647821
123542-47-2
pubchem.compound:647821
ZINC49582255
pubchem.compound:46835756
TC-064564
pubchem.compound:46835756
SEN 1269
pubchem.compound:46835756
SCHEMBL3602388
pubchem.compound:46835756
NCGC00387448-01
pubchem.compound:46835756
MolPort-009-685-119
pubchem.compound:46835756
MFPAAKZZUIRMKR-UHFFFAOYSA-N
pubchem.compound:46835756
I06-2365
pubchem.compound:46835756
FT-0682533
pubchem.compound:46835756
DTXSID40676566
pubchem.compound:46835756
DB-080315
pubchem.compound:46835756
CTK5H7888
pubchem.compound:46835756
CHEMBL2386874
pubchem.compound:46835756
AKOS015850742
pubchem.compound:46835756
A11161
pubchem.compound:46835756
956128-01-1
pubchem.compound:46835756
4350AF
pubchem.compound:46835756
3-[[5-[3-(dimethylamino)phenoxy]-2-pyrimidinyl]amino]phenol
pubchem.compound:46835756
3-({5-[3-(dimethylamino)phenoxy]pyrimidin-2-yl}amino)phenol
pubchem.compound:46835756
3-(5-(3-(dimethylamino)phenoxy)pyrimidin-2-ylamino)phenol
pubchem.compound:46835756
3-((5-(3-(Dimethylamino)phenoxy)pyrimidin-2-yl)amino)phenol
pubchem.compound:46835756
membrane nanotube
?
TNT
?
ME
?
CCH
?
Low-power laser irradiation
?
s1105
pubchem.compound:3973
cc-58
pubchem.compound:3973
ZX-AFC000490
pubchem.compound:3973
ZINC6014
pubchem.compound:3973
X7411
pubchem.compound:3973
UNII-31M2U1DVID
pubchem.compound:3973
Tocris-1130
pubchem.compound:3973
SYN1108
pubchem.compound:3973
SW217688-2
pubchem.compound:3973
ST24040926
pubchem.compound:3973
SR-01000076245-7
pubchem.compound:3973
SMR002530642
pubchem.compound:3973
SF-1101
pubchem.compound:3973
SF 1101
pubchem.compound:3973
SCHEMBL94377
pubchem.compound:3973
SC-85850
pubchem.compound:3973
SB10965
pubchem.compound:3973
S-7706
pubchem.compound:3973
RT-013609
pubchem.compound:3973
RS0074
pubchem.compound:3973
QC-7260
pubchem.compound:3973
PubChem16766
pubchem.compound:3973
NSC697286
pubchem.compound:3973
NSC-697286
pubchem.compound:3973
NSC 697286
pubchem.compound:3973
NCI60_034712
pubchem.compound:3973
NCGC00179253-01
pubchem.compound:3973
NCGC00025020-04
pubchem.compound:3973
NCGC00025020-03
pubchem.compound:3973
NCGC00025020-02
pubchem.compound:3973
NCGC00025020-01
pubchem.compound:3973
NCGC00015622-07
pubchem.compound:3973
NCGC00015622-06
pubchem.compound:3973
NCGC00015622-05
pubchem.compound:3973
NCGC00015622-04
pubchem.compound:3973
NCGC00015622-03
pubchem.compound:3973
NCGC00015622-02
pubchem.compound:3973
NCGC00015622-01
pubchem.compound:3973
MolPort-003-983-779
pubchem.compound:3973
MLS006010131
pubchem.compound:3973
M2410
pubchem.compound:3973
Lys 294002
pubchem.compound:3973
Lopac0_000710
pubchem.compound:3973
Lopac-L-9908
pubchem.compound:3973
LY294002
pubchem.compound:3973
LY2
pubchem.compound:3973
LY-924002
pubchem.compound:3973
LY-294002
pubchem.compound:3973
LY-294,002 hydrochloride, solid, >=98% (HPLC)
pubchem.compound:3973
LY-294,002
pubchem.compound:3973
LY 294002; 2-(4-Morpholino)-8-phenyl-4H-1-benzopyran-4-one
pubchem.compound:3973
LY 294002, LY-294002, 154447-36-6
pubchem.compound:3973
LY 294002
pubchem.compound:3973
LS-39828
pubchem.compound:3973
Kinome_3543
pubchem.compound:3973
KS-00000XP3
pubchem.compound:3973
KBioSS_000563
pubchem.compound:3973
KBioGR_000563
pubchem.compound:3973
KBio3_001006
pubchem.compound:3973
KBio3_001005
pubchem.compound:3973
KBio2_005699
pubchem.compound:3973
KBio2_003131
pubchem.compound:3973
KBio2_000563
pubchem.compound:3973
KB-231805
pubchem.compound:3973
KB-19284
pubchem.compound:3973
K00235
pubchem.compound:3973
J-510126
pubchem.compound:3973
InSolution™ LY 294002
pubchem.compound:3973
IN1268
pubchem.compound:3973
IN1266
pubchem.compound:3973
IDI1_002197
pubchem.compound:3973
HY-10108
pubchem.compound:3973
HSCI1_000206
pubchem.compound:3973
HMS3654M21
pubchem.compound:3973
HMS3649E04
pubchem.compound:3973
HMS3403M05
pubchem.compound:3973
HMS3229G17
pubchem.compound:3973
HMS1990M05
pubchem.compound:3973
HMS1792M05
pubchem.compound:3973
HMS1362M05
pubchem.compound:3973
H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-(9CI)
pubchem.compound:3973
H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl- (9CI)
pubchem.compound:3973
GTPL6004
pubchem.compound:3973
FT-0660382
pubchem.compound:3973
EX-A073
pubchem.compound:3973
EC-000.2341
pubchem.compound:3973
DTXSID6042650
pubchem.compound:3973
DB02656
pubchem.compound:3973
D0X7NA
pubchem.compound:3973
D09SFV
pubchem.compound:3973
CZQHHVNHHHRRDU-UHFFFAOYSA-N
pubchem.compound:3973
CTK0H1979
pubchem.compound:3973
CS-0150
pubchem.compound:3973
CHEMBL98350
pubchem.compound:3973
CHEBI:65329
pubchem.compound:3973
CCG-100633
pubchem.compound:3973
CBiol_002046
pubchem.compound:3973
C15195
pubchem.compound:3973
BiomolKI_000029
pubchem.compound:3973
BiomolKI2_000037
pubchem.compound:3973
Bio2_000922
pubchem.compound:3973
Bio2_000442
pubchem.compound:3973
Bio1_001310
pubchem.compound:3973
Bio1_000821
pubchem.compound:3973
Bio1_000332
pubchem.compound:3973
BSPBio_001223
pubchem.compound:3973
BRD-K27305650-001-05-9
pubchem.compound:3973
BMK1-D5
pubchem.compound:3973
BIL2940
pubchem.compound:3973
BDBM12915
pubchem.compound:3973
BCPP000177
pubchem.compound:3973
BCP9000880
pubchem.compound:3973
BCP00195
pubchem.compound:3973
BCBcMAP01_000117
pubchem.compound:3973
BC660045
pubchem.compound:3973
AS-16252
pubchem.compound:3973
API0015880
pubchem.compound:3973
AN-1305
pubchem.compound:3973
AKOS017344742
pubchem.compound:3973
AK162301
pubchem.compound:3973
AC1Q6CLU
pubchem.compound:3973
AC1L1H4N
pubchem.compound:3973
AC-30295
pubchem.compound:3973
AB0033714
pubchem.compound:3973
8-Phenyl-2-(morpholin-4-yl)-chromen-4-one
pubchem.compound:3973
4azt
pubchem.compound:3973
4H-1-Benzopyran-4-one,2-(4-morpholinyl)-8-phenyl-
pubchem.compound:3973
4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-(9CI)
pubchem.compound:3973
4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl- (9CI)
pubchem.compound:3973
4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-
pubchem.compound:3973
4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl
pubchem.compound:3973
4CA-0787
pubchem.compound:3973
31M2U1DVID
pubchem.compound:3973
2-morpholino-8-phenyl-chromen-4-one
pubchem.compound:3973
2-morpholino-8-phenyl-4H-chromen-4-one
pubchem.compound:3973
2-morpholin-4-yl-8-phenylchromen-4-one
pubchem.compound:3973
2-morpholin-4-yl-8-phenyl-4H-chromen-4-one
pubchem.compound:3973
2-Morpholino-8-phenylchromone
pubchem.compound:3973
2-Morpholino-8-phenyl-4-oxo-4H-1-benzopyran
pubchem.compound:3973
2-Morpholin-4-yl-8-phenyl-chromen-4-one
pubchem.compound:3973
2-MORPHOLIN-4-YL-7-PHENYL-4H-CHROMEN-4-ONE
pubchem.compound:3973
2-(morpholin-4-yl)-8-phenylchromen-4-one
pubchem.compound:3973
2-(morpholin-4-yl)-8-phenyl-4H-chromen-4-one
pubchem.compound:3973
2-(4-morpholino)-8-phenyl-4H-1-benzopyran-4-one
pubchem.compound:3973
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
pubchem.compound:3973
1yi3
pubchem.compound:3973
15447-36-6
pubchem.compound:3973
154447-36-6
pubchem.compound:3973
R4
?
MTBR R4
?
R3
?
MTBR R3
?
R2
?
MTBR R2
?
R1
?
MTBR R1
?
MTBR
?