? anatomy antibody aptamer biological process cellular component chemical chemical (proprietary) chemical class chemical mixture chemical role clinical measurement domain enzyme class epitope exposure genetic variant isoform molecular function motif pathology pathway peptide post-translational modification protein protein complex protein family protein fragment protein isoform family protein variant The motif in the MAPT protein where microtubule binding repeats microtubule-binding region MTBR pubmed:18500754 pubmed:2516729 interpro:IPR001084 orcid:0000-0003-4423-4370 position 569_591 of canonical isoform of MAPT protein tubulin-binding repeat 1 MTBR R1 R1 pubmed:18500754 orcid:0000-0001-9661-5277 p(HGNC:MAPT, frag(569_591)) position 592_621 of canonical isoform of MAPT protein tubulin-binding repeat 2 MTBR R2 R2 pubmed:18500754 orcid:0000-0001-9661-5277 p(HGNC:MAPT, frag(592_621)) position 623_653 of canonical isoform of MAPT protein tubulin-binding repeat 3 MTBR R3 R3 pubmed:18500754 orcid:0000-0001-9661-5277 p(HGNC:MAPT, frag(623_653)) position 654_685 of canonical isoform of MAPT protein tubulin-binding repeat 4 MTBR R4 R4 pubmed:18500754 orcid:0000-0001-9661-5277 p(HGNC:MAPT, frag(654_685)) Tau (MAPT) in its aggregated form (as Paired Helical Filaments (PHFs) or Straight Filaments (SF)) contains 5–9 moles of phosphate/ mole of the protein, defining it as hyper phosphorylated Tau aggregates pmc:PMC2633703 orcid:0000-0003-4423-4370 An excessive phosphorylation (see GO:0006468) hyperphosphorylation pubmed:22710920 orcid:0000-0003-4423-4370 temperature-sensitive allele of GAL80 (tub-GAL80TS) GAL80TS pmc:PMC3073608 orcid:0000-0002-6117-4413 CAST is known to prevent oligomerization of Tau (Rao et al., 2014) and α-synuclein (Diepenbroek et al. 2014) and inhibit reactive gliosis (Rao et al., 2008) Tau oligomers pmc:PMC4828294 orcid:0000-0002-6117-4413 a typo appearing in pubmed:23950935 for the specific PI3-kinase inhibitor that is actually named LY294002 LY293002 154447-36-6 15447-36-6 1yi3 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholino)-8-phenyl-4H-1-benzopyran-4-one 2-(morpholin-4-yl)-8-phenyl-4H-chromen-4-one 2-(morpholin-4-yl)-8-phenylchromen-4-one 2-MORPHOLIN-4-YL-7-PHENYL-4H-CHROMEN-4-ONE 2-Morpholin-4-yl-8-phenyl-chromen-4-one 2-Morpholino-8-phenyl-4-oxo-4H-1-benzopyran 2-Morpholino-8-phenylchromone 2-morpholin-4-yl-8-phenyl-4H-chromen-4-one 2-morpholin-4-yl-8-phenylchromen-4-one 2-morpholino-8-phenyl-4H-chromen-4-one 2-morpholino-8-phenyl-chromen-4-one 31M2U1DVID 4CA-0787 4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl 4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl- 4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl- (9CI) 4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-(9CI) 4H-1-Benzopyran-4-one,2-(4-morpholinyl)-8-phenyl- 4azt 8-Phenyl-2-(morpholin-4-yl)-chromen-4-one AB0033714 AC-30295 AC1L1H4N AC1Q6CLU AK162301 AKOS017344742 AN-1305 API0015880 AS-16252 BC660045 BCBcMAP01_000117 BCP00195 BCP9000880 BCPP000177 BDBM12915 BIL2940 BMK1-D5 BRD-K27305650-001-05-9 BSPBio_001223 Bio1_000332 Bio1_000821 Bio1_001310 Bio2_000442 Bio2_000922 BiomolKI2_000037 BiomolKI_000029 C15195 CBiol_002046 CCG-100633 CHEBI:65329 CHEMBL98350 CS-0150 CTK0H1979 CZQHHVNHHHRRDU-UHFFFAOYSA-N D09SFV D0X7NA DB02656 DTXSID6042650 EC-000.2341 EX-A073 FT-0660382 GTPL6004 H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl- (9CI) H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-(9CI) HMS1362M05 HMS1792M05 HMS1990M05 HMS3229G17 HMS3403M05 HMS3649E04 HMS3654M21 HSCI1_000206 HY-10108 IDI1_002197 IN1266 IN1268 InSolution™ LY 294002 J-510126 K00235 KB-19284 KB-231805 KBio2_000563 KBio2_003131 KBio2_005699 KBio3_001005 KBio3_001006 KBioGR_000563 KBioSS_000563 KS-00000XP3 Kinome_3543 LS-39828 LY 294002 LY 294002, LY-294002, 154447-36-6 LY 294002; 2-(4-Morpholino)-8-phenyl-4H-1-benzopyran-4-one LY-294,002 LY-294,002 hydrochloride, solid, >=98% (HPLC) LY-294002 LY-924002 LY2 LY294002 Lopac-L-9908 Lopac0_000710 Lys 294002 M2410 MLS006010131 MolPort-003-983-779 NCGC00015622-01 NCGC00015622-02 NCGC00015622-03 NCGC00015622-04 NCGC00015622-05 NCGC00015622-06 NCGC00015622-07 NCGC00025020-01 NCGC00025020-02 NCGC00025020-03 NCGC00025020-04 NCGC00179253-01 NCI60_034712 NSC 697286 NSC-697286 NSC697286 PubChem16766 QC-7260 RS0074 RT-013609 S-7706 SB10965 SC-85850 SCHEMBL94377 SF 1101 SF-1101 SMR002530642 SR-01000076245-7 ST24040926 SW217688-2 SYN1108 Tocris-1130 UNII-31M2U1DVID X7411 ZINC6014 ZX-AFC000490 cc-58 s1105 pubmed:23950935 cas:154447-36-6 chebi:CHEBI:65329 drugbank:DB02656 inchi:InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2 pubchem.compound:3973 smiles:C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4 orcid:0000-0002-3034-9970 Low-power laser irradiation (LPLI) is a non-damage physical therapy LPLI Low-power laser irradiation pubmed:20333643 orcid:0000-0002-3034-9970 Chronic cerebral hypoperfusion (CCH) is one of the causes of vascular dementia (VaD) and is also an etiological factor for Alzheimer's disease (AD) Chronic cerebral hypoperfusion CCH pubmed:24575038 orcid:0000-0002-3034-9970 ethanol extracted from Mori Fructus, a well-known traditional herbal medicine, food, and dietary supplement Mori Fructus ethanol extract ME pubmed:26068423 orcid:0000-0002-3034-9970 filamentous-actin-containing membranous structures that bridge and connect cells tunneling nanotubes TNT membrane nanotube pubmed:27809932 orcid:0000-0002-3034-9970 production of amyloid amyloidogenesis pubmed:24653673 orcid:0000-0002-3034-9970 alpha-synuclein (SNCA) aggregate in fibrillar or oligomeric forms, usually found in Lewy bodies alpha-synuclein aggregates pubmed:23254192 orcid:0000-0003-4423-4370 huntingtin (HTT) protein fragments aggregations huntingtin aggregates pubmed:12747895 orcid:0000-0003-4423-4370 aggregation of amyloid-beta fragments of the APP protein amyloid-beta aggregates pubmed:23484434 orcid:0000-0003-4423-4370 A tau aggregation inhibitor SEN-1269 3-((5-(3-(Dimethylamino)phenoxy)pyrimidin-2-yl)amino)phenol 3-(5-(3-(dimethylamino)phenoxy)pyrimidin-2-ylamino)phenol 3-({5-[3-(dimethylamino)phenoxy]pyrimidin-2-yl}amino)phenol 3-[[5-[3-(dimethylamino)phenoxy]-2-pyrimidinyl]amino]phenol 4350AF 956128-01-1 A11161 AKOS015850742 CHEMBL2386874 CTK5H7888 DB-080315 DTXSID40676566 FT-0682533 I06-2365 MFPAAKZZUIRMKR-UHFFFAOYSA-N MolPort-009-685-119 NCGC00387448-01 SCHEMBL3602388 SEN 1269 TC-064564 ZINC49582255 pubmed:23484434 chembl:CHEMBL2386874 inchi:InChI=1S/C18H18N4O2/c1-22(2)14-6-4-8-16(10-14)24-17-11-19-18(20-12-17)21-13-5-3-7-15(23)9-13/h3-12,23H,1-2H3,(H,19,20,21) pubchem.compound:46835756 smiles:CN(C)C1=CC(=CC=C1)OC2=CN=C(N=C2)NC3=CC(=CC=C3)O orcid:0000-0003-4423-4370 A tau aggregation inhibitor MLS000034832 123542-47-2 3-Phenyl-4-oxo-5-amino-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylic acid ethyl ester 5-Amino-4-oxo-3-phenyl-3,4-dihydro-thieno[3,4-d]pyridazine-1-carboxylic acid eth 5-Amino-4-oxo-3-phenyl-3,4-dihydro-thieno[3,4-d]pyridazine-1-carboxylic acid ethyl ester AC1LDGR2 AC1Q34EJ AKOS000601368 BAS 06046551 BDBM50253793 CCG-115473 CHEMBL461431 F2135-0238 HLVGVGCIJRBRQW-UHFFFAOYSA-N HMS1616C21 HMS2339G13 L-4233 MCULE-6208802152 MLS000034832 MLS002539346 MolPort-001-835-700 NCGC00031883-02 SCHEMBL7885074 SMR000013604 ZINC563211 ethyl 5-amino-4-oxo-3-phenyl-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate ethyl 5-amino-4-oxo-3-phenyl-3H,4H-thieno[3,4-d]pyridazine-1-carboxylate ethyl 5-amino-4-oxo-3-phenylthieno[3,4-d]pyridazine-1-carboxylate pubmed:23484434 chembl:CHEMBL461431 inchi:InChI=1S/C15H13N3O3S/c1-2-21-15(20)12-10-8-22-13(16)11(10)14(19)18(17-12)9-6-4-3-5-7-9/h3-8H,2,16H2,1H3 pubchem.compound:647821 smiles:CCOC(=O)C1=NN(C(=O)C2=C(SC=C21)N)C3=CC=CC=C3 orcid:0000-0003-4423-4370 A tau aggregation inhibitor caprospinol ((20S,22R,25R)-Spirosta-5-ene-3beta-ol)hexanoate (22R,25R)-20alpha-Spirost-5-en-3beta-yl hexanoate (3beta,8xi,9xi,14xi,16xi,17xi,20R,22xi,25R)-Spirost-5-en-3-yl hexanoa 4952-56-1 9BU4T267E4 AKOS015955746 CAPROSPINOL DB05263 Diosgenin caproate Diosgenin, hexanoate J2.343.184J MCULE-6852340934 MolPort-002-507-344 SP-223 SP-233 Spirost-5-en-3-ol, 3-hexanoate, (3beta,25R)- UNII-9BU4T267E4 ZINC97971833 pubmed:23484434 drugbank:DB05263 inchi:InChI=1S/C33H52O4/c1-6-7-8-9-29(34)36-24-13-15-31(4)23(18-24)10-11-25-26(31)14-16-32(5)27(25)19-28-30(32)22(3)33(37-28)17-12-21(2)20-35-33/h10,21-22,24-28,30H,6-9,11-20H2,1-5H3/t21-,22+,24+,25-,26+,27+,28+,30+,31+,32+,33-/m1/s1 pubchem.compound:16394575 smiles:CCCCCC(=O)O[C@H]1CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](C[C@@H]5O[C@]6(CC[C@@H](C)CO6)[C@@H](C)[C@H]45)[C@@H]3CC=C2C1 orcid:0000-0003-4423-4370 Small aggregates of amyloid-beta amyloid-beta oligomers pubmed:29196815 pubmed:24918635 orcid:0000-0003-4423-4370 Amyloid-beta oligomers composed specifically of amyloid-beta 42 amyloid-beta 42 oligomers pubmed:24918635 orcid:0000-0003-4423-4370 C-terminally truncated carboxyl-terminal fragments (CTFs) of APP APP C-terminally truncated carboxyl-terminal fragments pubmed:15491160 orcid:0000-0002-0303-8616 A2B5 antigen is a cell surface ganglioside epitope expressed on developing thymic epithelial cells, oligodendrocyte progenitors, and neuroendocrine cells. A2B5 antigen pubmed:1497614 orcid:0000-0002-0303-8616 Sphingomyelin phosphodiesterase (EC 3.1.4.12, also known as neutral sphingomyelinase, sphingomyelinase, or SMase) is a hydrolase enzyme that is involved in sphingolipid metabolism reactions. neutral sphingomyelinase pubmed:19519303 ec-code:3.1.4.12 orcid:0000-0002-0303-8616 Neurodegeneration is the progressive loss of structure or function of neurons, including death of neurons. Many neurodegenerative diseases – including amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease, and Huntington's disease – occur as a result of neurodegenerative processes. Neurodegeneration pubmed:12387894 pubmed:20202123 hp:HP:0002180 orcid:0000-0002-0303-8616 soluble oligomeric forms of the amyloid beta peptide known as amyloid-derived diffusible ligands (ADDLs) are the toxic species responsible for neurodegeneration associated with Alzheimer's disease. amyloid-beta derived diffusible ligands ADDL pubmed:19188609 orcid:0000-0002-0303-8616 increased secretion of the pancreatic hormone amylin Hyperamylinemia pubmed:23794448 orcid:0000-0002-0303-8616 APOE e4 is a variant of APOE, it's APOE-ε4 (arg112, arg158). APOE e4 pubmed:22701550 orcid:0000-0002-0303-8616 N-AcGIP is a rat hormone that is an agonist of GIP N-AcGIP pubmed:18234983 orcid:0000-0002-0303-8616 Pro3-GIP is a rat hormone that is an agonist of GIP Pro3-GIP AKOS034831571 [Pro3]-GIP (Rat) pubmed:18234983 inchi:InChI=1S/C226H343N61O64S/c1-21-115(12)181(285-216(341)165(109-289)279-201(326)151(92-126-63-67-131(293)68-64-126)266-210(335)163(102-179(309)310)276-215(340)164(108-288)280-221(346)183(117(14)23-3)284-214(339)153(91-124-48-28-25-29-49-124)277-222(347)184(121(18)290)281-175(302)107-247-217(342)166-60-45-84-287(166)224(349)120(17)251-188(313)134(232)89-125-61-65-130(292)66-62-125)219(344)250-119(16)187(312)254-146(77-85-352-20)197(322)274-160(99-176(303)304)208(333)258-141(58-38-43-82-231)198(323)283-182(116(13)22-2)220(345)261-142(59-44-83-243-226(240)241)191(316)259-144(70-74-168(234)295)195(320)260-145(71-75-169(235)296)196(321)273-161(100-177(305)306)209(334)267-152(90-123-46-26-24-27-47-123)213(338)282-180(114(10)11)218(343)278-159(98-173(239)300)207(332)268-155(94-128-104-245-136-53-33-31-51-133(128)136)203(328)264-149(87-112(6)7)200(325)263-148(86-111(4)5)199(324)249-118(15)186(311)253-143(69-73-167(233)294)194(319)255-137(54-34-39-78-227)189(314)246-106-174(301)252-138(55-35-40-79-228)190(315)256-139(56-36-41-80-229)193(318)271-157(96-171(237)298)206(331)275-162(101-178(307)308)211(336)269-154(93-127-103-244-135-52-32-30-50-132(127)135)202(327)257-140(57-37-42-81-230)192(317)270-156(95-129-105-242-110-248-129)204(329)272-158(97-172(238)299)205(330)265-150(88-113(8)9)212(337)286-185(122(19)291)223(348)262-147(225(350)351)72-76-170(236)297/h24-33,46-53,61-68,103-105,110-122,134,137-166,180-185,244-245,288-293H,21-23,34-45,54-60,69-102,106-109,227-232H2,1-20H3,(H2,233,294)(H2,234,295)(H2,235,296)(H2,236,297)(H2,237,298)(H2,238,299)(H2,239,300)(H,242,248)(H,246,314)(H,247,342)(H,249,324)(H,250,344)(H,251,313)(H,252,301)(H,253,311)(H,254,312)(H,255,319)(H,256,315)(H,257,327)(H,258,333)(H,259,316)(H,260,320)(H,261,345)(H,262,348)(H,263,325)(H,264,328)(H,265,330)(H,266,335)(H,267,334)(H,268,332)(H,269,336)(H,270,317)(H,271,318)(H,272,329)(H,273,321)(H,274,322)(H,275,331)(H,276,340)(H,277,347)(H,278,343)(H,279,326)(H,280,346)(H,281,302)(H,282,338)(H,283,323)(H,284,339)(H,285,341)(H,286,337)(H,303,304)(H,305,306)(H,307,308)(H,309,310)(H,350,351)(H4,240,241,243) pubchem.compound:131954578 smiles:CCC(C)C(C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)C)C(=O)NC(CC(=O)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(CCC(=O)N)C(=O)NC(CCCCN)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)NC(CCCCN)C(=O)NC(CC6=CNC=N6)C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)O)C(=O)NC(CCC(=O)N)C(=O)O)NC(=O)C(CCCCN)NC(=O)C(CC(=O)O)NC(=O)C(CCSC)NC(=O)C(C)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(CC7=CC=C(C=C7)O)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)CC)NC(=O)C(CC8=CC=CC=C8)NC(=O)C(C(C)O)NC(=O)CNC(=O)C9CCCN9C(=O)C(C)NC(=O)C(CC1=CC=C(C=C1)O)N orcid:0000-0002-0303-8616 PI3K-Akt signaling pathway is an intracellular signaling pathway important in regulating the cell cycle.It is described in KEGG. PI3K-Akt signaling pathway pubmed:22013558 kegg.pathway:hsa04151 orcid:0000-0002-0303-8616 Argyrophilic grain disease (AGD) is an under-recognized, distinct, highly frequent sporadic tauopathy, with a prevalence reaching 31.3% in centenarians. Argyrophilic Grain Disease AGD pubmed:15658002 orcid:0000-0002-0303-8616 Granulovacuolar degeneration (GVD) is one of the pathological hallmarks of Alzheimer's disease (AD), and it is defined as electron-dense granules within double membrane-bound cytoplasmic vacuoles. granulovacuolar degeneration GVD pubmed:17455299 hp:HP:0002528 orcid:0000-0002-0303-8616 mitochondria function disorder mitochondrial dysfunction pubmed:19885299 orcid:0000-0002-0303-8616 Insoluble fibrous protein aggregates exhibiting beta sheet structure. amyloid-beta fibrils pubmed:19158505 orcid:0000-0003-4423-4370 a peptide derived from mouse laminin alpha 1 protein (seq:RKRLQVQLSIRT, chain:2719–2730) AG73 pubmed:20615691 orcid:0000-0002-3034-9970 p(MGI:Lama1, frag(2719_2730)) Notch intracellular domain is the intracellular region of notch receptor. Notch intracellular domain pubmed:20883690 orcid:0000-0002-0303-8616 YENTY is the endocytosis motif of Amyloid precursor protein. YENPTY endocytosis motif (APP) YENPTY pubmed:18650430 orcid:0000-0002-0303-8616 Soluble amyloid precursor protein sAPP-beta soluble amyloid precursor protein pubmed:21606494 orcid:0000-0002-0303-8616 A growth factor is a naturally occurring substance capable of stimulating cellular growth, proliferation, healing, and cellular differentiation. Usually it is a protein or a steroid hormone. Growth factors are important for regulating a variety of cellular processes. growth factor pubmed:14678766 ncit:C20424 umls:C0018284 orcid:0000-0002-0303-8616 Tau isoforms containing 3 tubulin binding repeats 3R tau pubmed:23407988 orcid:0000-0001-9661-5277 Tau isoforms containing 4 tubulin binding repeats 4R tau pubmed:23407988 orcid:0000-0001-9661-5277 A hexapeptide motif located in the R2, that promotes the formation of PHF VQIINK motif PHF6* pubmed:17493042 orcid:0000-0001-9661-5277 A hexapeptide motif located in the R3, that promotes the formation of PHF VQIVYK motif PHF6 pubmed:17493042 orcid:0000-0001-9661-5277 Extracellular NFT remains after neuron death, considered to be the last stage of NFT-related pathological activity. ghost tangles pubmed:8431763 pubmed:23407988 orcid:0000-0001-9661-5277 Pretangles are cytoplasmic tau immunoreactivity in neurons without apparent formation of fibrillary structures. In Alzheimer disease, such tau deposition is considered to represent a premature state prior to fibril formation (AD-pretangles), later to form neurofibrillary tangles and finally ghost tangles. pretangles pubmed:23407988 pubmed:24612177 orcid:0000-0001-9661-5277 Corresponding roughly to the N-terminal part of the tau molecule, consisting mainly of acidic residues and containing two distinct alternatively spliced N-terminal inserts. projection domain MAP2/Tau projection pubmed:17493042 pubmed:28386764 interpro:IPR013588 orcid:0000-0001-9661-5277 A constitutively active splicing isoform of RAC1 (Ras-related C3 botulinum toxin substrate 1), first identified in breast and colon cancer. RAC1b pubmed:22142809 uniprot.isoform:P63000-2 orcid:0000-0001-9661-5277 A heterotetrameric adapter protein complex involved in cargo-internalization during clathrin-mediated endocytosis. Composed of alpha and beta subunits (large adaptins), mu and sigma subunits (minor adaptins). AP-2 complex pubmed:27260836 go:GO:0030122 orcid:0000-0001-9661-5277 Longest tau isoform in human brain, most commonly used as the conventional tau. Tau isoform F (441 aa) 2N4R htau40 microtubule-associated protein tau isoform 2 pubmed:17493042 ncbiprotein:NP_005901 uniprot.isoform:P10636-8 orcid:0000-0001-9661-5277 Human fetal tau isoform. Tau isoform Fetal-tau (352 aa) 0N3R htau23 microtubule-associated protein tau isoform 4 pubmed:17493042 ncbiprotein:NP_058525 uniprot.isoform:P10636-2 orcid:0000-0001-9661-5277 Human brain tau isoform, derived from alternative splicing. Tau isoform B (381 aa) 1N3R htau37 microtubule-associated protein tau isoform 7 pubmed:17493042 ncbiprotein:NP_001190180 uniprot.isoform:P10636-4 orcid:0000-0001-9661-5277 Human brain tau isoform, derived from alternative splicing. Tau isoform D (383 aa) 0N4R htau24 microtubule-associated protein tau isoform 3 pubmed:17493042 ncbiprotein:NP_058518 uniprot.isoform:P10636-6 orcid:0000-0001-9661-5277 Human brain tau isoform, derived from alternative splicing. Tau isoform C (410 aa) 2N3R htau39 microtubule-associated protein tau isoform 8 pubmed:17493042 ncbiprotein:NP_001190181 uniprot.isoform:P10636-5 orcid:0000-0001-9661-5277 Human brain tau isoform, derived from alternative splicing. Tau isoform E (412 aa) 1N4R htau34 microtubule-associated protein tau isoform 5 pubmed:17493042 ncbiprotein:NP_001116539 uniprot.isoform:P10636-7 orcid:0000-0001-9661-5277 ? Serpin-enzyme complex receptor SEC-R pubmed:2160076 pubmed:15160835 orcid:0000-0002-0303-8616 inflammatory response in the brain and nervous tissue. neuroinflammation pubmed:26306439 go:GO:0150076 orcid:0000-0002-3034-9970 happens when a biological, physical or chemical agent cause any adverse effect on the structure and function of the nerves system. neurotoxicity pubmed:18440072 orcid:0000-0002-3034-9970 when the neurite is unable it outgrow and extend neurite retraction pubmed:19022228 orcid:0000-0002-3034-9970 the APP gene is located on chromosome 21 in humans with three major isoforms arising from alternative splicing [3]. These are APP695, APP751 and APP770 (containing 695, 751, and 770 amino acids, respectively) APP695 pubmed:21214928 uniprot.isoform:P05067-4 orcid:0000-0002-6117-4413 the APP gene is located on chromosome 21 in humans with three major isoforms arising from alternative splicing [3]. These are APP695, APP751 and APP770 (containing 695, 751, and 770 amino acids, respectively) APP751 pubmed:21214928 uniprot.isoform:P05067-8 orcid:0000-0002-6117-4413 the APP gene is located on chromosome 21 in humans with three major isoforms arising from alternative splicing [3]. These are APP695, APP751 and APP770 (containing 695, 751, and 770 amino acids, respectively) APP770 pubmed:21214928 uniprot.isoform:P05067-1 orcid:0000-0002-6117-4413 gamma-secretase is a high molecular weight complex minimally composed of four components: presenilins (PS), nicastrin, anterior pharynx defective 1 (APH-1), and presenilin enhancer 2 (PEN-2) gamma-secretase pubmed:25565961 fplx:Gamma_secretase orcid:0000-0002-6117-4413 soluble amyloid precursor protein-alpha sAPP-alpha pubmed:22491325 orcid:0000-0002-6117-4413 Excitotoxicity is defined as cell death resulting from the toxic actions of excitatory amino acids Excitotoxicity pubmed:19343058 orcid:0000-0002-6117-4413 a fragment containing the last 31 amino acids of APP (called C31) C31 pubmed:21214928 orcid:0000-0002-6117-4413 Additional gamma-cleavage further generates the fragment (called Jcasp) containing the region between gamma- and caspase-cleavage sites Jcasp pubmed:21214928 orcid:0000-0002-6117-4413 APP intracellular domain AICD pubmed:21214928 orcid:0000-0002-6117-4413 APP alphaCTF and betaCTF are further cleaved by gamma-secretase to generate p83 and Abeta, respectively p83 pubmed:21214928 orcid:0000-0002-6117-4413 Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein (see:GO:0016485) APP processing pubmed:21214928 orcid:0000-0002-6117-4413 soluble Aβ oligomers AβOs pubmed:24685176 orcid:0000-0002-7128-929X The formation of AβOs starts from alterations in the conformation of monomeric Aβ, resulting in low molecular weight (LMW) dimers and trimers, followed by aggregation to soluble spherical oligomers consisted of 12–24 monomers. LMW amyloid oligomers pubmed:18723507 orcid:0000-0002-7128-929X Amyloid-beta oligomers composed specifically of amyloid-beta 40 amyloid-beta 40 oligomers pubmed:21209907 orcid:0000-0002-7128-929X The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition (see:GO:0000380) alternative splicing of APP gene pubmed:22122372 orcid:0000-0002-6117-4413 The ectodomains of APP and APLPs have two conserved regions called E1 and E2 (Fig. 1A), both of which have been proposed to contribute to dimerization E1 domain pubmed:21574595 orcid:0000-0002-6117-4413 The ectodomains of APP and APLPs have two conserved regions called E1 and E2 (Fig. 1A), both of which have been proposed to contribute to dimerization E2 domain pubmed:21574595 orcid:0000-0002-6117-4413 Cleavage by α-secretase yields the nonamyloidogenic soluble 3-kDa peptide (p3) that does not form amyloid fibrils, whereas cleavage by β-secretase yields the amyloidogenic form Aβ1–40 or the longer, more fibrillogenic Aβ1–42 P3 peptide pubmed:22137428 orcid:0000-0002-6117-4413 a membrane associated C-terminal fragment consisting of 99 amino acids (C99) C99 pubmed:22122372 orcid:0000-0002-6117-4413 amnestic Mild Cognitive Impairement is a cognitive dysfunction that is associated with memory deficits aMCI pubmed:18986241 orcid:0000-0002-3034-9970 multi-domain Mild Cognitive Impairement is a cognitive dysfunction that is associated with more than one cognitive domain mdMCI pubmed:18986241 orcid:0000-0002-3034-9970 Human brain tau isoform, derived from alternative splicing. Tau isoform A (316 aa) pubmed:18986241 uniprot.isoform:P10636-3 orcid:0000-0002-3034-9970 Tau epitope cleaved at aspartic acid(421). Tau C3 pubmed:18986241 orcid:0000-0002-3034-9970 Tau epitope truncated at glutamic acid(391). Tau MN423 pubmed:18986241 orcid:0000-0002-3034-9970 When the oligomer lengthens, it adapts a beta-sheet structure and transforms into a detergent-insoluble aggregate with granular appearance under Atomic Force Microscopy (AFM) granular tau oligomers pubmed:28420982 orcid:0000-0002-6117-4413 As these granular tau oligomers fuse together, they form tau fibrils, which ultimately form NFTs Tau fibrils pubmed:28420982 orcid:0000-0002-6117-4413 Dense-core plaques are fibrillar deposits of Abeta, showing all the classical properties of amyloid including beta-sheet secondary structure, while diffuse plaques are amorphous deposits dense core plaques pubmed:17680701 orcid:0000-0002-6117-4413 A handful of proteins implicated in neurodegenerative diseases have been found to produce pore-like amyloid structures known as annular protofibrils (APFs) Tau annular protofibrils pubmed:28420982 orcid:0000-0002-6117-4413 monoclonal antibody, named TOC1 (tau oligomeric complex 1), which selectively labels tau dimers and oligomers, but does not label filaments TOC1 pubmed:22817713 orcid:0000-0002-6117-4413 fibrillar aggregates of alpha-synuclein, found in Lewy bodies alpha-synuclein fibrils pubmed:19892735 orcid:0000-0002-7128-929X oligomeric aggregates of alpha-synuclein alpha-synuclein oligomers pubmed:17374364 orcid:0000-0002-7128-929X the Lys-specific molecular tweezer CLR01 has been shown to inhibit aggregation and toxicity of multiple amyloidogenic protein CLR01 pubmed:23183235 orcid:0000-0002-7128-929X prefibrillar oligomers formed at early stages of α-syn assembly prefibrillar α-synuclein oligomers pubmed:27075649 orcid:0000-0002-7128-929X Glyceraldehyde-derived (GA) advanced glycation end products GA-AGE pubmed:16630055 pubmed:15221334 orcid:0000-0001-9661-5277 Short isoform of tissue transglutaminase TGM2 Isoform 3 (349 aa) pubmed:12578227 uniprot.isoform:P21980-2 orcid:0000-0001-9661-5277 Conserved Tau phosphorylation motif. Part of the microtubule-binding region, phosphorylation of the serine in these motifs disrupts tau binding to the MT and serves to regulate tau-mediated MT assembly KXGS motif pubmed:17304350 pubmed:21215781 orcid:0000-0001-9661-5277 CBD is a late-onset neurodegenerative disease involving the cerebral cortex and the basal ganglia, characterized by widespread deposition of hyperphosphorylated 4-repeat tau in neurons and glia, the latter as astrocytic plaques Corticobasal Degeneration pubmed:22057784 orcid:0000-0001-9661-5277 Component of NFT, consisting in a helical arrangement of tau protomers paired helical filaments pubmed:1706519 pubmed:22496370 orcid:0000-0001-9661-5277 Component of NFT and ultrastructural polymorph of PHFs, with an assymetrical arrangement of the tau protomers straight filaments pubmed:28678775 pubmed:16566606 orcid:0000-0001-9661-5277 Murine IgM-class monoclonal antibody recognizing a specific conformational epitope adopted by tau during PHF formation Alz50 pubmed:16566606 pubmed:8955115 orcid:0000-0001-9661-5277 A non-canonical glycosylation involving the attachment of single O-linked N-acetylglucosamine (O-GlcNAc) moieties to serine and threonine residues of cytoplasmic, nuclear, and mitochondrial proteins O-GlcNAcylation pubmed:16630055 orcid:0000-0001-9661-5277 The non-enzymatic reaction between the electrophilic carbonyl groups of a reducing sugar and the free amino groups of tau amino acids (especially of basic lysine or arginine residues) leading to the formation of a ketoamine (Amadori product), an intermediate of AGE synthesis. glycation pubmed:26655600 orcid:0000-0001-9661-5277 Incorporation of a nitrogen dioxide (NO2) group in tyrosine residues (mostly) of proteins forming 3-nitrotyrosine (3-NT). A biomarker of cell, tissue and systemic nitrosative stress. nitration pubmed:16566606 orcid:0000-0001-9661-5277 The reaction of polyamination by transglutaminases (TGs) involves a glutamine (Q) as acyl donor and a lysine (K) as acyl acceptor. It generates a (gamma)-glutamyl-(epsilon)-lysine isopeptide bond that causes protein cross-linking polyamination pubmed:25974414 orcid:0000-0001-9661-5277 The addition of a formyl functional group usually at the epsilon amino group of Lys residues formylation pubmed:21210655 orcid:0000-0001-9661-5277 IterPro:IPR001050 Syndecan Family pubmed:15241784 orcid:0000-0002-0303-8616 The process of bacteria invading a cell Bacterial invasion pubmed:15241784 orcid:0000-0002-0303-8616 Dopmine secrete in a homeostatic way dopamine homeostasis pubmed:26325389 orcid:0000-0002-0303-8616 The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo.pubmed:23509287 PINK1-Park pathway pubmed:26182419 orcid:0000-0002-0303-8616 The excitotoxicity of Glutamate Glutamate excitotoxicity pubmed:10196525 orcid:0000-0002-0303-8616 The interplay between mitophagy and mitochondrial biogenesis. mitochondrial homeostasis pubmed:25478815 orcid:0000-0002-0303-8616 reference:pubmed:22577383 ER mitochondria interorganellar crosstalk pubmed:25478815 orcid:0000-0002-0303-8616 reference:pubmed:22399422 Mitochondrial pathway pubmed:23313576 orcid:0000-0002-0303-8616 Oxidative protein folding is a process that is responsible for the formation of disulfide bonds between cysteine residues in proteins. The driving force behind this process is a redox reaction, in which electrons pass between several proteins and finally to a terminal electron acceptor. oxidative protein folding pubmed:26004228 orcid:0000-0002-0303-8616 The motility of mitochondria mitochondrial motility pubmed:25565208 orcid:0000-0002-0303-8616 The TIM/TOM complex is a protein complex in cellular biochemistry which translocates proteins produced from nuclear DNA through the mitochondrial membrane for use in oxidative phosphorylation. Only 13 proteins necessary for a mitochondrion are actually coded in mitochondrial DNA. TIM/TOM complex pubmed:25565208 orcid:0000-0002-0303-8616 The aggregation of mitochondria mitochondrial aggregation pubmed:25591737 orcid:0000-0002-0303-8616 The mevalonate pathway, also known as the isoprenoid pathway or HMG-CoA reductase pathway is an essential metabolic pathway present in eukaryotes, archaea, and some bacteria mevalonate pathway pubmed:24695221 orcid:0000-0002-0303-8616 UBERON:dopaminergic cell groups Dopaminergic cell groups pubmed:24695221 orcid:0000-0002-0303-8616 The precursor protein of mitochondria mitochondrial precursor protein pubmed:26192197 orcid:0000-0002-0303-8616 the nematode homolog of Parkin PDR-1 pubmed:26430570 orcid:0000-0002-0303-8616 the nematode homolog of PINK1 PINK-1 pubmed:26430570 ncbigene:173918 wb:WBGene00017137 orcid:0000-0002-0303-8616 the nematode homolog of Skn1 skn-1 pubmed:25896323 orcid:0000-0002-0303-8616 the nematode homolog of Bcl-2 ced-9 pubmed:25896323 orcid:0000-0002-0303-8616 the nematode homolog of Lgg1 lgg-1 pubmed:25896323 orcid:0000-0002-0303-8616 the nematode homolog of Clec65 clec-65 pubmed:25896323 orcid:0000-0002-0303-8616 the nematode homolog of Clec4 clec-4 pubmed:25896323 orcid:0000-0002-0303-8616 exotoxin A is an exotoxin produced by Pseudomonas aeruginosa.It inhibits elongation factor-2. It does so by ADP-ribosylation of EF2. This then causes the elongation of polypeptides to cease. exotoxin A pubmed:25274306 orcid:0000-0002-0303-8616 mitochondrial damage-associated molecular patterns mitochondrial DAMPs pubmed:20203610 orcid:0000-0002-0303-8616 The IκB kinase is an enzyme complex that is involved in propagating the cellular response to inflammation. IκB kinase pubmed:19880420 fplx:IKK_family orcid:0000-0002-0303-8616 Nonshivering thermogenesis was originally defined as a cold-induced increase in heat production not associated with the muscle activity of shivering. Recent research shows it to be a metabolic process located primarily in brown adipose tissue and controlled by the activity of the sympathetic nervous supply of this tissue non-shivering thermogenesis pubmed:6722594 pubmed:16224498 orcid:0000-0002-0303-8616 the nematode homologus of hsp16 hsp-16 pubmed:22700657 orcid:0000-0002-0303-8616 Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions. They were first described in relation to heat shock, heat shock proteins pubmed:15280428 mesh:D006360 orcid:0000-0002-0303-8616 Diets with high calorie. high-calorie diets pubmed:10412986 orcid:0000-0002-0303-8616 To function, proteins must undergo a folding process that gives them the proper three dimensional structure. Numerous genetic and biochemical observations suggest that proteins that fail to fold properly impair cell function. This process, also referred to as proteotoxicity, is particularly important to the fate of non-renewable cells of long-lived organisms in which malfolded proteins (proteotoxins) can exert their deleterious influence over extended periods of time.reference:Proteotoxicity and Aging proteotoxicity pubmed:24149988 orcid:0000-0002-0303-8616 A SNP located within the 3' UTR of FGF20, is significantly associated with PD risk ss20399075 pubmed:15122513 orcid:0000-0002-0303-8616 The formation of alpha-synuclein oligmer Alpha-synuclein Oligomerization pubmed:21296890 orcid:0000-0002-0303-8616 A microsatellite markers for Alzheimer’s and Parkinson’s Diseases D6S253 pubmed:9560156 orcid:0000-0002-0303-8616 A microsatellite markers for Alzheimer’s and Parkinson’s Diseases D6S305 pubmed:9560156 orcid:0000-0002-0303-8616 In Parkinson's Disease, TT+AA is more frequent in MTHFR gene. MTHFR,TT+AA pubmed:17914182 orcid:0000-0002-0303-8616 CAG repeats in genes. CAG repeats pubmed:22782013 orcid:0000-0002-0303-8616 The function of gastrotestine disorder. Gastrointestinal dysfunctions pubmed:24467967 orcid:0000-0002-0303-8616 UBERON:olfactory epithelium olfactory epithelium pubmed:22691461 orcid:0000-0002-0303-8616 The nasal cycle is the often unnoticed alternating partial congestion and decongestion of the nasal cavities in humans and other animals. It is a physiological congestion of the nasal concha, also called the nasal turbinate, due to selective activation of one half of the autonomic nervous system by the hypothalamus. nasal cycle pubmed:23569018 orcid:0000-0002-0303-8616 Hyposmia is a reduced ability to smell and to detect odors.Hyposmia might be a very early sign of Parkinson's disease. Hyposmia is also an early and almost universal finding in Alzheimer's disease and dementia with Lewy bodies. Lifelong hyposmia could be caused by Kallmann syndrome. hyposmia pubmed:23933572 orcid:0000-0002-0303-8616 A premutation (PM) expansion (55-200 CGG) in the fragile X mental retardation gene 1 causes elevated messenger RNA and reduced fragile X mental retardation gene 1 protein. FMR1,(55-200 CGG) pubmed:24332449 orcid:0000-0002-0303-8616 a new member of the F-box family, Pof14, which forms a canonical pof14 pubmed:17016471 orcid:0000-0002-0303-8616 MeSH Unique ID: D009457 Neuroglia pubmed:19248803 mesh:D009457 orcid:0000-0002-0303-8616 The GDNF family of ligands (GFL) consists of four neurotrophic factors: glial cell line-derived neurotrophic factor (GDNF), neurturin (NRTN), artemin (ARTN), and persephin (PSPN). GFLs have been shown to play a role in a number of biological processes including cell survival, neurite outgrowth, cell differentiation and cell migration. In particular signalling by GDNF promotes the survival of dopaminergic neurons. GDNF Family pubmed:10383122 orcid:0000-0002-0303-8616 MeSH Unique ID: D009046 Motor Neurons pubmed:10383122 mesh:D009046 orcid:0000-0002-0303-8616 Cell:noradrenergic neuron noradrenergic neuron pubmed:10383122 orcid:0000-0002-0303-8616 Cell:midbrain dopaminergic neuron midbrain dopaminergic neuron pubmed:10383122 orcid:0000-0002-0303-8616 A neurite or neuronal process refers to any projection from the cell body of a neuron. Neurites pubmed:23872421 mesh:D016501 orcid:0000-0002-0303-8616 BPS domain of protein GRB10 GRB10,BPS domain pubmed:25268761 orcid:0000-0002-0303-8616 A chromosomal fragile site is a specific heritable point on a chromosome that tends to form a gap or constriction and may tend to break when the cell is exposed to partial replication stress.Based on their frequency, fragile sites are classified as common or rare.To date, more than 120 fragile sites have been identified in the human genome. common fragile site pubmed:12874785 orcid:0000-0002-0303-8616 The alpha helices of PARK7 protein PARK7-alpha helices pubmed:18707128 orcid:0000-0002-0303-8616 The cleaved part of Protein PINK1 cleaved PINK1 pubmed:21138942 orcid:0000-0002-0303-8616 The brain hyperaemia, or coupling, is accomplished by a group of cells, closely related to each other; called neurovascular unit (NVU). The neurovascular unit is composed by neurones, astrocytes, endothelial cells of blood-brain barrier (BBB), myocytes, pericytes and extracellular matrix components neurovascular unit pubmed:24629161 pubmed:25136294 orcid:0000-0002-0303-8616 MeSH Unique ID: D009132 Muscles pubmed:21151955 mesh:D009132 orcid:0000-0002-0303-8616 MeSH Unique ID: D058953 Neural Stem Cell pubmed:22357600 mesh:D058953 orcid:0000-0002-0303-8616 MeSH Unique ID: D017557 Ventral Tegmental Area pubmed:16190884 mesh:D017557 orcid:0000-0002-0303-8616 MeSH Unique ID: D065842 Pars Compacta pubmed:16190884 mesh:D065842 orcid:0000-0002-0303-8616 Correspounding to residues I151 to Q244 of the 441 aa tau isoform, separated into P1 and P2. Possible role in tau's functional stabilization through the reported intramolecular interaction of P2 with R1, R2 and R4 from the microtubule-binding region proline-rich domain P domain PRD pubmed:25974414 pubmed:8068626 pubmed:9190213 orcid:0000-0001-9661-5277 the nematode homolog of Lys2 lys-2 pubmed:25896323 orcid:0000-0003-4423-4370 the nematode homolog of Abf2 abf-2 pubmed:25896323 orcid:0000-0003-4423-4370 The lower cleft between domains 1 and 3 is lined by residues Tyr143, Ala144, Gly146, Thr148, Gly168, Ile341, Ile345, Leu346, Leu349, Thr351, and Met355, which are predominantly hydrophobic. This cleft constitutes the major binding site for most ABPs and also mediates important longitudinal contacts between actin subunits in the filament hydrophobic pocket of actin pubmed:21314430 orcid:0000-0002-6117-4413 The 310-helix is the fourth most common type of secondary structure in proteins after α-helices, β-sheets, and reverse turns (Barlow and Thornton 1988). Approximately 15%–20% of all helices in protein structures are 310-helices, which are commonly found as N- or C-terminal extensions to an α-helix (Barlow and Thornton 1988). 310-Helices in proteins are typically only three to five residues long compared with a mean of 10–12 residues for α-helices (Richardson and Richardson 1988) 310-helix pubmed:12761385 orcid:0000-0002-6117-4413 Amino Acid Sequence: Ac-Leu-Gly-Arg-Leu-Ser-Gln-Glu-Leu-His-Arg-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2 Amylin Antagonist AC253 pubmed:22500019 orcid:0000-0002-3034-9970 The cyclin dependent kinase 5 regulatory subunit 1 (CDK5R1), also known as p35, is cleaved by Calpain to produce the p25 fragment CDK5R1 p25 pubmed:10830966 orcid:0000-0002-3034-9970 p(HGNC:CDK5R1, frag(99_307)) PTI-125 is a proprietary small molecule that preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its alpha7nAChR/TLR4 associations and downstream pathologies PTI-125 pubmed:28438486 pubmed:22815492 orcid:0000-0002-6117-4413 In addition to nAChRs forming from different subunit assemblages, stoichiometric study has shown that α4β2 nAChRs can form as either (α4)3(β2)2 or (α4)2(β2)3, the latter having a greater affinity for both nicotine and Ach alpha-4 beta-2 nAChR pubmed:24828779 orcid:0000-0002-6117-4413 Accumulating evidence demonstrates that these α7 and β2 nAChR subunits can co-assemble to form functional α7β2 nAChRs in heterologous expression systems, and also under natural conditions in the brain (Figure 1) alpha-7 beta-2 nAChR pubmed:27179601 orcid:0000-0002-6117-4413 The β2 subunit can couple with non-α4 subunits, including α2, α3 and α6 subunits to form functionally distinct nAChRs, but these receptors are much less densely expressed in the central nervous system relative to α4β2* nAChRs (*indicating potential assemblage of β2 subunits with non-α4 subunits) beta-2-containing nAChR pubmed:24828779 orcid:0000-0002-6117-4413 56 kDa soluble amyloid-β (Aβ) assembly Abeta*56 pubmed:16541076 orcid:0000-0002-3034-9970 Aggregates of proteins or fragments of proteins protein aggregates pubmed:23484434 pmc:PMC2633703 pubmed:23254192 pubmed:12747895 mesh:D066329 sbo:SBO:0000543 orcid:0000-0003-4423-4370 results from the cleavage of beta APP by gamma-secretase sAPP-gamma pubmed:12105112 orcid:0000-0002-3034-9970 alpha6-containing receptors, which in brain occur as heteropentamers with beta2 and beta3 and are especially enriched in presynaptic nerve terminals in striatum (Champtiaux et al.,2002) alpha-6-containing nAChR pubmed:28445721 pubmed:19498417 orcid:0000-0002-6117-4413 Tau domain located in the N-terminal region encompassing residues 2-18. It activates phosphatase PP1 which dephosphorylates Ser9 in GSK3Beta and leads to its activation. In normal tau, both NTD and CTD are folded back in proximity to each other forming a 'paper-clip' conformation, which masks the PAD. Phosphorylation in the AT8 epitope, disrupts this normal conformational state, exposing the PAD by moving away the terminal domains. phosphatase-activating domain pubmed:28413156 pubmed:26671985 orcid:0000-0001-9661-5277 Autocatalytic cysteine-mediated acetylation of Lys residues in the MTBR upon incubation of tau proteins with acetyl-CoA, possible even in absence of enzymatic activity.This activity may be suppressed when tau is bound to tubulin or MTs, but activated upon tau dissociation during pathological conditions that abrogate tau-MT interactions, thus allowing acetyl-CoA accessibility to free tau cysteines. cystein-dependent auto-acetylation pubmed:27383765 pubmed:28002468 orcid:0000-0001-9661-5277 Pathological hallmarks of Alzheimer Disease, consisting in intraneuronal accumulations of large membrane-bound vacuoles. Associated with the late stages of disease progression, they were also shown to be immunopositive or GSK3Beta and SYK (Spleen Tyrosine Kinase). GVD bodies pubmed:26501932 orcid:0000-0001-9661-5277 Advanced glycation end products (AGEs) are the production of Maillard reaction between carbohydrates and proteins. They cause neurotoxicity via production of ROS followed by an increase in expression of APP and amyloid beta. Recent analysis implicates them in tau phosphorylation. advanced glycation end product pubmed:28176663 orcid:0000-0001-9661-5277 A long lasting enhancement in synaptic transmission between two neurons, most commonly studied in the synapse between the Schaffer collateral axons of the CA3 neurons and the CA1 pyramidal neurons of the hippocampus. Alongside the LTD (long-term depression) represent the two mechanisms of memory formation and storage. Impairment of this process in AD is caused by soluble oligmoeric amyloid beta. long-term potentiation pubmed:27041503 mesh:D017774 orcid:0000-0001-9661-5277 Part of the wider proline-rich domain, divided between the projection and assembly domains, this region together with the MTBR mediate tau interaction and binding to F actin. proline-rich region 1 pubmed:21757739 orcid:0000-0001-9661-5277 Part of the wider proline-rich domain, divided between the projection and assembly domains, this region together with the MTBR mediate tau interaction and binding to F actin. proline-rich region 2 pubmed:21757739 orcid:0000-0001-9661-5277 Tau assembly domain consists of the second part of the proline-rich region (PR2), MTBR and CTD, corresponding to residues 199-441 of the canonical tau isoform. assembly domain pubmed:21757739 orcid:0000-0001-9661-5277 Cullin-RING E3 ubiquitin ligase complex 4, consisting of CUL4(A,B), DDB1 and CRBN. CRL4 complex pubmed:27325702 orcid:0000-0001-9661-5277 Cytosolic region of APP, responsible for interacting with E3 ubiquitin ligases among other proteins. APP, ACR pubmed:27325702 orcid:0000-0001-9661-5277 Detyrosination is a form of posttranslational modification that occurs on alpha-tubulin. It consists of the removal of the C-terminal tyrosine to expose a glutamate at the newly formed C-terminus. Promoted by Tau truncation in the Gln124 residue. tubulin detyrosination pubmed:25974414 orcid:0000-0001-9661-5277 An intense reaction of microglia following CNS insult, characterized by active proliferation and retracted cellular processes. In AD, accumulation of Abeta can be a possible cause of such physiological phenomenon, as microglia is seen surrounding senile plaques. Abeta interaction with microglial pattern recognition receptors (PRRs) leads to NLRP3 inflammasome activation, production of toxic NOS and ROS and release of proinflammatory cytokines. Microgliosis pubmed:29121589 orcid:0000-0001-9661-5277 Morphological and functional changes observed in astrocytes in the context of their physiological response to CNS trauma or injury caused by ischemia, stroke, autoimmune disorders and neurodegeneration. Astrogliosis pubmed:29121589 orcid:0000-0001-9661-5277 The CK1 group of eukaryotic protein kinases are composed of seven CK1 isoforms (CK1α, CK1α2, CK1δ, CK1ε, CK1γ1, CK1γ2, and CK1γ3), two Tau–tubulin kinase isoforms (TTBK1 and TTBK2), and three VRK isoforms (VRK1, VRK2, and VRK3) CK1 superfamily pubmed:25673844 orcid:0000-0001-9661-5277 nAChRs that bind radiolabeled nicotine with the highest affinity contain a4 subunits (a4*-nAChR) alpha-4-containing nAChR pubmed:21787755 orcid:0000-0002-7128-929X a4 subunits can also assemble with b4 subunits to form a4b4-nAChRs that have comparably high nicotine affinity alpha-4 beta-4 nAChR pubmed:21787755 orcid:0000-0002-7128-929X Another prominent nAChR subtype found in vertebrate central and autonomic nervous systems contains a7 subunits. alpha-7-containing nAChR pubmed:21787755 orcid:0000-0002-7128-929X Neurotoxic proteins from the venom of the banded or Formosan krait (Bungarus multicinctus, an elapid snake). alpha-Bungarotoxin pubmed:21787755 uniprot:P60616 orcid:0000-0002-7128-929X nAChRs containing the a3b2 subunit interface alpha-3 beta-2 nAChR pubmed:21787755 orcid:0000-0002-7128-929X kappa-Bungarotoxin, a snake venom kappa-neurotoxin, is a potent neuronal nicotinic receptor antagonist (pubmed:3359187) kappa-Bungarotoxin pubmed:3359187 pubmed:21787755 uniprot:P01398 orcid:0000-0002-7128-929X highly selective M4 (mAChR) allosteric potentiator. Chemical name: 3-Amino-N-[(4-chlorophenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide VU10010 2-Fly 2-Furoyl-LIGRLO-amide trifluoroacetate salt 2-Furoyl-LIGRLO-amide trifluoroacetate salt, >=97% (HPLC) 2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2 trifluoroacetate salt 2-f-LIGRLO-NH2 2-fAP 2fLI 3-Amino-N-(4-chlorobenzyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide 2,2,2-trifluoroacetate 3-amino-N-(4-chlorobenzyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide 3-amino-N-[(4-chlorophenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide 633283-39-3 A3274/0139289 AC1LEM0C AKOS000282930 B7285 BDBM50323691 CHEMBL1212994 CTK5B8654 D0N2VN DTXSID30351931 FPRULFHDSFKYBV-UHFFFAOYSA-N HMS3431D09 KB-81468 MCULE-8947006791 MLS002474501 MolPort-002-722-568 NCGC00378784-01 RT-016241 SMR001398666 SR-01000147542 SR-01000147542-1 STL227650 VU 10010 VU-10010 VU0402469-1 VU10010 ZINC109066 cid_714286 f-LIGRLO-NH2 pubmed:18059262 pubmed:24511233 cas:633283-39-3 inchi:InChI=1S/C17H16ClN3OS/c1-9-7-10(2)21-17-13(9)14(19)15(23-17)16(22)20-8-11-3-5-12(18)6-4-11/h3-7H,8,19H2,1-2H3,(H,20,22) pubchem.compound:714286 smiles:CC1=C2C(SC(C(NCC3=CC=C(Cl)C=C3)=O)=C2N)=NC(C)=C1 orcid:0000-0002-6117-4413 M1-selective PAM that potentiates M1 (mAChR). Chemical name:1-[4,6-difluoro-1-[6-(1-methylpyrazol-4-yl)pyridin-3-yl]indol-3-yl]sulfonyl-3-(5-methyl-1,2-oxazol-3-yl)propan-2-one VU0456940 VU 0456940 VU-0456940 VU0456940 pubmed:24511233 inchi:InChI=1S/C24H19F2N5O4S/c1-14-5-17(29-35-14)8-19(32)13-36(33,34)23-12-31(22-7-16(25)6-20(26)24(22)23)18-3-4-21(27-10-18)15-9-28-30(2)11-15/h3-7,9-12H,8,13H2,1-2H3 iupac:1-[4,6-difluoro-1-[6-(1-methylpyrazol-4-yl)pyridin-3-yl]indol-3-yl]sulfonyl-3-(5-methyl-1,2-oxazol-3-yl)propan-2-one smiles:CN1N=CC(C2=CC=C(N3C=C(S(=O)(CC(CC4=NOC(C)=C4)=O)=O)C5=C3C=C(F)C=C5F)C=N2)=C1 orcid:0000-0002-6117-4413 selective M4 (mAChR) allosteric potentiator. Chemical name: 3-Amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide VU0152099 3-amino-4,6-dimethyl-N-piperonyl-thieno[2,3-b]pyridine-2-carboxamide 3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethyl-2-thieno[2,3-b]pyridinecarboxamide 3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide 3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[5,4-b]pyridine-2-carboxamide 3-amino-N-(2H-1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide 3-amino-N-(benzo[d][1,3]dioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine carboxamide 3-azanyl-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxamide 612514-42-8 AC1LTW64 AC1Q2P5R AKOS002170228 BDBM48044 D0Y1VB GTPL3256 HMS3843E06 MCULE-6171593814 MLS002474500 MolPort-000-437-290 Oprea1_621562 SMR001398665 STK207844 VU0152099 VU0152099-1 ZINC1472126 cid_1541501 pubmed:24511233 inchi:InChI=1S/C18H17N3O3S/c1-9-5-10(2)21-18-14(9)15(19)16(25-18)17(22)20-7-11-3-4-12-13(6-11)24-8-23-12/h3-6H,7-8,19H2,1-2H3,(H,20,22) pubchem.compound:1541501 smiles:CC1=CC(=NC2=C1C(=C(S2)C(=O)NCC3=CC4=C(C=C3)OCO4)N)C wikidata:Q27089173 orcid:0000-0002-6117-4413 selective M1(mAChR)-PAM. Chemical name: 2-(4-Ethoxyanilino)-N'-[(Z)-(2-oxonaphthalen-1-ylidene)methyl]acetohydrazide VU0029767 2-(4-ethoxyanilino)-N'-[(E)-(2-oxonaphthalen-1-ylidene)methyl]acetohydrazide 2-[(4-ethoxyphenyl)amino]-N'-[(2-hydroxy-1-naphthyl)methylene]acetohydrazide (non-preferred name) 326001-01-8 AKOS028114549 AOB2484 BCP17383 D0L5AG KS-000046FP ZINC1204219 ZINC38534584 pubmed:24590577 inchi:InChI=1S/C21H21N3O3/c1-2-27-17-10-8-16(9-11-17)22-14-21(26)24-23-13-19-18-6-4-3-5-15(18)7-12-20(19)25/h3-13,22-23H,2,14H2,1H3,(H,24,26) pubchem.compound:6758210 smiles:CCOC1=CC=C(C=C1)NCC(=O)NNC=C2C(=O)C=CC3=CC=CC=C32 orcid:0000-0002-6117-4413 selective M1(mAChR)-PAM. Chemical name: Cyclopentyl 3,4-dimethyl-6-(6-nitro-1,3-benzodioxol-5-yl)-2-oxo-1,6-dihydropyrimidine-5-carboxylate VU0090157 AC1MER3E AKOS001633711 AKOS022078796 BIM-0042576.P001 CBMicro_042727 D0O6BD EU-0038260 GTPL3259 MCULE-4339280714 MolPort-002-181-662 Oprea1_103541 SR-01000433423 SR-01000433423-1 STK079398 UNM000000551301 VU0090157 cyclopentyl 1,6-dimethyl-4-(6-nitro-1,3-benzodioxol-5-yl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate cyclopentyl 1,6-dimethyl-4-(6-nitro-1,3-benzodioxol-5-yl)-2-oxo-3,4-dihydropyrimidine-5-carboxylate cyclopentyl 1,6-dimethyl-4-(6-nitrobenzo[d][1,3]-dioxol-5-yl)-2-oxo-1,2,3,4 tetrahydropyrimidine-5-carboxylate cyclopentyl 1,6-dimethyl-4-(6-nitrobenzo[d][1,3]-dioxol-5-yl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate cyclopentyl 3,4-dimethyl-6-(6-nitro-1,3-benzodioxol-5-yl)-2-oxo-1,6-dihydropyrimidine-5-carboxylate pubmed:24590577 inchi:InChI=1S/C19H21N3O7/c1-10-16(18(23)29-11-5-3-4-6-11)17(20-19(24)21(10)2)12-7-14-15(28-9-27-14)8-13(12)22(25)26/h7-8,11,17H,3-6,9H2,1-2H3,(H,20,24) pubchem.compound:2882724 smiles:CC1=C(C(NC(=O)N1C)C2=CC3=C(C=C2[N+](=O)[O-])OCO3)C(=O)OC4CCCC4 orcid:0000-0002-6117-4413 M1(mAChR) allosteric agonists. Chemical name: Ethyl 4-(2-benzamidoethylamino)piperidine-1-carboxylate hydrochloride VU0184670 1135241-95-0 CHEMBL1535797 MLS002279950 SMR001318088 VU0184670 ethyl 4-(2-benzamidoethylamino)piperidine-1-carboxylate hydrochloride pubmed:24590577 chembl:CHEMBL1535797 inchi:InChI=1S/C17H25N3O3.ClH/c1-2-23-17(22)20-12-8-15(9-13-20)18-10-11-19-16(21)14-6-4-3-5-7-14;/h3-7,15,18H,2,8-13H2,1H3,(H,19,21);1H pubchem.compound:25010774 smiles:CCOC(=O)N1CCC(CC1)NCCNC(=O)C2=CC=CC=C2.Cl orcid:0000-0002-6117-4413 Inhibits Fyn localization in lipid rafts and subsequently inhibits the fyn-dependent Abeta redistribution and accumulation in lipid rafts, process linked with ADDL-induced cell death. 2-Bromohexadecanoic acid .alpha.-Bromopalmitic acid 18263-25-7 2-Bromohexadecanoic acid 2-Bromohexadecanoic acid, >=99.0% (GC) 2-Bromohexadecanoic acid, purum, >=97.0% (GC) 2-Bromohexadecanoic acid, ~97% 2-Bromopalmitate 2-Bromopalmitic acid 2-bromanylhexadecanoic acid 2-bromo-hexadecanoic acid 2-bromopalmitate, (+-)-isomer 40305-76-8 A812715 AC1L32UD AC1Q2444 ACM18263257 ACMC-1C7OL AKOS003404931 AKOS017343270 BDBM50148454 C-20189 C16H31BrO2 CAS-18263-25-7 CC-09685 CHEBI:133152 CHEMBL118417 CTK4D8252 DB-044471 DPRAYRYQQAXQPE-UHFFFAOYSA-N DSSTox_CID_17734 DSSTox_GSID_37734 DSSTox_RID_79368 DTXSID0037734 EINECS 242-137-0 FT-0611564 Hexadecanoic acid, 2-bromo- Hexadecanoic acid,2-bromo- I04-8986 J-011689 KB-68336 L213 LMFA01090011 LS-174823 MCULE-7613431163 MFCD00004215 MolPort-001-759-724 NCGC00164251-01 NCGC00164251-02 NCGC00254935-01 NCIOpen2_007723 NSC 58378 NSC-58378 NSC58378 OR10833 SBB071635 SCHEMBL97565 ST45026694 TC-170832 TRA0083226 Tox21_301033 VZ24096 ZX-AT022731 alpha-Bromopalmitic acid bromohexadecanoic acid pubmed:18096814 chebi:CHEBI:133152 inchi:InChI=1S/C16H31BrO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(17)16(18)19/h15H,2-14H2,1H3,(H,18,19) pubchem.compound:82145 smiles:CCCCCCCCCCCCCCC(C(=O)O)Br orcid:0000-0001-9661-5277 The catalytic core of the 26 S proteasome system, responsible for tau degradation 20 S Proteasome pubmed:17954934 pubmed:19145068 orcid:0000-0001-9661-5277 An oxidation product consisting of covalent ortho-ortho coupling between two tyrosine residues formed as a conseguence to UV irradiation, gamma-irradiation, aging, exposure to oxygen free radicals, nitrogen dioxide, peroxynitrite, and lipid hydroperoxides. ROS catalyzed by Cu ions are involved in the generation of these cross-links in amyloid beta oligomers to which they provide stability. Also involved in the stabilization of tau PHF. A potential biomarker of oxidative stress in AD. 3-3 dityrosine cross-linking pubmed:16566606 pubmed:24351276 orcid:0000-0001-9661-5277 A disease propagation and progression model, composed of six stages of increasing pathological severity determined by the location of the tangle-bearing neurons and the amplitude of the pathophysiological changes. Transentorhinal stages I-II: correspond to clinically silent cases of very mildly affected subjects, showing no cognitive impairment. NFT are slowly and gradually developping. Braak_Stage I pubmed:7566337 pubmed:28176663 orcid:0000-0001-9661-5277 A disease propagation and progression model, composed of six stages of increasing pathological severity determined by the location of the tangle-bearing neurons and the amplitude of the pathophysiological changes. Transentorhinal stages I-II: correspond to clinically silent cases of very mildly affected subjects, showing no cognitive impairment. NFT are slowly and gradually developping. Braak_Stage II pubmed:7566337 pubmed:28176663 orcid:0000-0001-9661-5277 A disease propagation and progression model, composed of six stages of increasing pathological severity determined by the location of the tangle-bearing neurons and the amplitude of the pathophysiological changes.Limbic stages III-IV designate an incipient Alzheimer's disease, since due to the lack of neocortical destruction, stages III and IV do not meet the currently used criteria for neuropathologic diagnosis of AD. Stage III is characterised by the destruction of the external principal stratum of the entorhinal laminae presenting considerable amounts of NFT and neuropil threads. Braak_Stage III pubmed:7566337 orcid:0000-0001-9661-5277 A disease propagation and progression model, composed of six stages of increasing pathological severity determined by the location of the tangle-bearing neurons and the amplitude of the pathophysiological changes.Limbic stages III-IV designate an incipient Alzheimer's disease, since due to the lack of neocortical destruction, stages III and IV do not meet the currently used criteria for neuropathologic diagnosis of AD. Stage IV is characterised by the destruction of the internal principal stratum of the entorhinal laminae presenting considerable amounts of NFT and neuropil threads. The destruction of entorhinal cellular layers interferes with the normal transfer of information between neocortex and hippocampus, manifesting as cognitive impairment and subtle personality changes. Braak_Stage IV pubmed:7566337 orcid:0000-0001-9661-5277 A disease propagation and progression model, composed of six stages of increasing pathological severity determined by the location of the tangle-bearing neurons and the amplitude of the pathophysiological changes.neocortical stages V-VI correspond to fully developed Alzheimer's disease. These stages are characterized by large numbers of NFTs in all sections of cerebral cortex and present neocortical damage thus contributing to the development of the conventional neuropathological criteria for the clinical diagnosis of AD. Braak_Stage V pubmed:7566337 pubmed:28176663 orcid:0000-0001-9661-5277 A disease propagation and progression model, composed of six stages of increasing pathological severity determined by the location of the tangle-bearing neurons and the amplitude of the pathophysiological changes.neocortical stages V-VI correspond to fully developed Alzheimer's disease. These stages are characterized by large numbers of NFTs in all sections of cerebral cortex and present neocortical damage thus contributing to the development of the conventional neuropathological criteria for the clinical diagnosis of AD. Braak_Stage VI pubmed:7566337 orcid:0000-0001-9661-5277 A peptide with sequence:GFPLKRHDGVDDLSKVG, originally synthesized by Helicobacter Pylori acting as a specific MARK kinase inhibitor, decreasing tau phosphorylation CagA peptide pubmed:23666762 pubmed:19966800 orcid:0000-0001-9661-5277 Shortest isoform of Microtubule affinity regulating kinase 4 (MARK4) derived from alternatvie splicing. It is upregulated during the early stages of neuron differentiation. MARK4 isoform 2 (688 aa) pubmed:16973293 uniprot.isoform:Q96L34-2 orcid:0000-0001-9661-5277 Loss of function mutant of DYRK1A isoform 1 NP_001387.2:p.Arg205del pubmed:28167836 orcid:0000-0001-9661-5277 Loss of function mutant of DYRK1A isoform 1 NP_001387.2:p.Glu239del pubmed:28167837 orcid:0000-0001-9661-5277 Prion protein fragment 106-126. This peptide increases membrane microviscosity, intracellular Ca2+ concentration and cell migration in circulating leucocytes, and oxygen production in monocytes and neutrophils. It also induces apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in the GH3 cell lines. PrP (106–126) stimulates leucocyte migration in a dose-dependent manner. Inhibits tau phosphorylaton at Ser262. Seq = KTNMKHMAGAAAAGAVVGGLG PrP106-126 pubmed:22692785 orcid:0000-0001-9661-5277 The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. Purkinje cell layer of cerebellar cortex pubmed:29221819 orcid:0000-0001-9661-5277 Tau antibody with specificity for pSer262 Tau antibody, AGG5759 pubmed:23666762 orcid:0000-0001-9661-5277 Tau murine monoclonal antibody with specificity for pSer262 Tau antibody, Tau-13 pubmed:23666762 orcid:0000-0001-9661-5277 Tau epitope consisting of pSer262 and pSer356 Tau epitope, 12E8 pubmed:22156579 orcid:0000-0001-9661-5277 Tau epitope consisting of pThr231 Tau epitope, AT180 pubmed:22833681 orcid:0000-0001-9661-5277 Tau epitope consisting of pSer202, pThr205, pSer208, pSer199 Tau epitope, AT8 pubmed:18239272 orcid:0000-0001-9661-5277 Tau epitope consisting of pSer202 Tau epitope, CP13 pubmed:25331948 orcid:0000-0001-9661-5277 Tau epitope consisting of pSer396, pSer404 Tau epitope, PHF1 pubmed:22156579 orcid:0000-0001-9661-5277 Dysfunctional axons and terminals that accumulate the β-site amyloid precursor protein (APP) cleaving enzyme (BACE1) required for Aβ generation. dystrophic neurite pubmed:28877763 orcid:0000-0001-9661-5277 The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer granular layer of cerebellar cortex pubmed:29221819 orcid:0000-0001-9661-5277 The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells molecular layer of cerebellar cortex pubmed:29221819 orcid:0000-0001-9661-5277 Isoform of KALRN protein Kalirin 7 pubmed:27796283 orcid:0000-0001-9661-5277 Tauopathies characterized by a relatively higher presence of the 4R tau isoforms, such as Alzheimers Disease and Corticobasal Degeneration 4R tauopathy pubmed:21427723 orcid:0000-0001-9661-5277 Ricolinostat is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity. Ricolinostat selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation. This leads to an accumulation of unfolded and misfolded ubiquitinated proteins and may eventually induce cancer cell apoptosis, and inhibition of cancer cell growth. HDAC6, a class II HDAC deacetylase located in the cytoplasm, appears to play a key role in the formation and activation of the aggresomes needed for degradation of misfolded proteins. Compared to non-selective HDAC inhibitor, ACY-1215 is able to reduce the toxic effects on normal, healthy cells. ACY-1215 1316214-52-4 2-(Diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide 2-(Diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide 2-(diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]pyrimidine-5-carboxamide 5-Pyrimidinecarboxamide, 2-(diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)- 5-Pyrimidinecarboxamide, 2-(diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]- 7-{[2-(DIPHENYLAMINO)PYRIMIDIN-5-YL]FORMAMIDO}-N-HYDROXYHEPTANAMIDE A11940 AB0032517 AC-30258 ACN-030031 ACY-1215 ACY-63 ACY1215 AH4 AJ-128539 AK151416 AKOS024259260 AX8288032 BC600387 BCP06028 BDBM50439674 CHEBI:95073 CHEMBL2364628 CS-0965 D0TP9M D10661 DB12376 DTXSID40157148 EX-A139 GTPL7010 HMS3653F17 HY-16026 J-690127 KB-74507 KS-00000SAV MFCD22666356 MLS006011181 MolPort-028-600-031 N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)pyrimidine-5-carboxamide NCGC00345802-01 NCGC00345802-05 Ricolinostat Ricolinostat (ACY-1215) Ricolinostat (USAN/INN) Ricolinostat [USAN:INN] Rocilinostat Rocilinostat (ACY-1215) SB17054 SCHEMBL574580 SMR004702950 ST24039648 SW219836-1 UNII-WKT909C62B US8609678, 2-(diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide [26] W-5979 WKT909C62B X5832 ZINC89630354 rocilinostat-acy-1215 s8001 pubmed:24844691 cas:1316214-52-4 chebi:CHEBI:95073 drugbank:DB12376 inchi:InChI=1S/C24H27N5O3/c30-22(28-32)15-9-1-2-10-16-25-23(31)19-17-26-24(27-18-19)29(20-11-5-3-6-12-20)21-13-7-4-8-14-21/h3-8,11-14,17-18,32H,1-2,9-10,15-16H2,(H,25,31)(H,28,30) mesh:C572255 pubchem.compound:53340666 smiles:C1=CC=C(C=C1)N(C2=CC=CC=C2)C3=NC=C(C=N3)C(=O)NCCCCCCC(=O)NO orcid:0000-0001-9661-5277 Interacts with tubulin binding repeat 1 APOE e3 pubmed:26751493 orcid:0000-0001-9661-5277 A cell-permeable imidazopyrimidine compound that acts a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC50 = 10 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src even at concentrations as high as 4.7 µM. Shown to inhibit Syk-mediated cellular functions in vitro and exhibit good oral bioavailability and in vivo effacacy in the treatment of various allgery and asthma conditions in rat models. Indirect inhibitory effect on GSK3B activity BAY61-3606 2-((7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl)amino)nicotinamide 2-(7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-ylamino)nicotinamide hydrochloride 2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide 2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidine-5-yl]amino]-3-pyridinecarboxamide 2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide 3-Pyridinecarboxamide, 2-((7-(3,4-dimethoxyphenyl)imidazo(1,2-C)pyrimidin-5-yl)amino)- 61G8S0H9KX 732983-37-8 A11320 AC-29888 ACN-053214 AKOS030526888 BAY 61-3606 BAY 61-3606 HCl BAY-61-360 BAY-61-3606 free base BAY-613606 BAY61-3606 BCP08946 BDBM50325991 BRD-K53281329-001-01-9 CCG-102604 CHEBI:91426 CHEMBL1190711 CHEMBL1242100 CS-0235 EX-A1437 GTPL9693 HY-76474 J-507625 KB-74859 Kinome_3125 NCGC00346945-01 NCGC00346945-06 RL04784 SCHEMBL373774 Syk inhibitor IV UNII-61G8S0H9KX ZINC3817793 cc-526 pubmed:25331948 cas:732983-37-8 chebi:CHEBI:91426 inchi:InChI=1S/C20H18N6O3/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19/h3-11H,1-2H3,(H2,21,27)(H,23,24,25) mesh:C477642 pubchem.compound:10200390 smiles:COC1=C(C=C(C=C1)C2=CC3=NC=CN3C(=N2)NC4=C(C=CC=N4)C(=O)N)OC wikidata:Q27163275 orcid:0000-0001-9661-5277 Chemical compund group acting as inhibitors of HDAC family proteins. Biphenyl-4-yl-acrylohydroxamoc acids pubmed:26890116 orcid:0000-0001-9661-5277 Ectorhinal area 36 is a subdivision of the cytoarchitecturally defined temporal region of cerebral cortex. With its medial boundary corresponding approximately to the rhinal sulcus it is located primarily in the fusiform gyrus. Cytoarchitecturally it is bounded laterally and caudally by the inferior temporal area 20, medially by the perirhinal area 35 and rostrally by the temporopolar area 38 (H) (Brodmann-1909). Together with Brodmann area 35, it comprises the perirhinal cortex. Brodmann (1909) area 36 pubmed:23407988 orcid:0000-0001-9661-5277 PCAF and NFkappaB inhibitor, showed anti-inflammatory properties and improved cognition C-30-27 pubmed:25672970 inchi:InChI=1S/C20H26ClN3O3/c1-25-19-13-16(14-22-6-7-24-8-10-26-11-9-24)12-18(21)20(19)27-15-17-4-2-3-5-23-17/h2-5,12-13,22H,6-11,14-15H2,1H3 smiles:C1COCCN1CCNCC2=CC(=C(C(=C2)Cl)OCC3=CC=CC=N3)OC orcid:0000-0001-9661-5277 Inhibitor of EP300 acetylase C646 (E)-4-(4-((5-(4,5-diMethyl-2-nitrophenyl)furan-2-yl)Methylene)-3-Methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid 328968-36-1 4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid 4-[(4E)-4-[[5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid 4-[(4E)-4-{[5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl]methylidene}-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid AC1LPE4S AKOS005418912 AOB5549 BC600370 BRD-K68548958-001-01-2 C 646 C-646 C646 CHEMBL3734823 CS-3529 EX-A1063 HY-13823 KB-145969 MolPort-002-976-806 SCHEMBL14991291 STK219801 ZINC13838357 pubmed:20869593 inchi:InChI=1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12+ pubchem.compound:1285940 smiles:CC1=C(C=C(C(=C1)C2=CC=C(O2)C=C3C(=NN(C3=O)C4=CC=C(C=C4)C(=O)O)C)[N+](=O)[O-])C orcid:0000-0001-9661-5277 Part of hippocampus proper bounded by CA2 and the subiculum, characterized by pyramidal neurons that receive projections from pyramidal neurons of CA3 via the Schaffer collaterals. CA1 field of hippocampus pubmed:23407988 mesh:D056547 orcid:0000-0001-9661-5277 Part of hippocampus proper bounded by areas CA3 and CA1, characterized by a narrow layer of large pyramidal cells, similar in size to CA3 pyramidal cells, but which lack the mossy fiber input from the dentate gyrus CA2 field of hippocampus pubmed:23407988 mesh:D056651 orcid:0000-0001-9661-5277 Part of hippocampus proper bounded by the hilus of the dentate gyrus and area CA2, characterized by large pyramidal cells and a dense projection from dentate gyrus granule cell mossy fibers. CA3 field of hippocampus pubmed:23407988 mesh:D056654 orcid:0000-0001-9661-5277 The last of four regions in the cornu ammonis of the hippocampus and is also part of the hilus of the dentate gyrus. This area contains mostly mossy cells that receive inputs from the dentate gyrus and pyramidal cells in the CA3 region and also projects back to the dentate gyrus. CA4 field of hippocampus pubmed:23407988 orcid:0000-0001-9661-5277 Inhibitor of GAPDH nitrosylation, abrogated Abeta induced tau acetylation and subsequent pathological impairments related to AD CGP3466B (Dibenzo(b,f)oxepin-5-ylmethyl)(methyl)prop-2-yn-1-amine 181296-84-4 5V14HD0N4Q 634202-78-1 AC1O4WBX CGP 3466 CGP-3466 CGP-3499B CHEBI:41778 CHEMBL1232111 D06KSV DB12879 DTXSID10171098 Dibenzo(b,f)oxepin-10-ylmethyl-methyl-prop-2-ynylamine N-(DIBENZO[B,F]OXEPIN-10-YLMETHYL)-N-METHYL-N-PROP-2-YNYLAMINE N-(benzo[b][1]benzoxepin-5-ylmethyl)-N-methylprop-2-yn-1-amine N-(dibenzo[b,f]oxepin-10-ylmethyl)-N-methylprop-2-yn-1-amine NCGC00346431-01 Neuroprotectant, Novartis Neuroprotectant, Santhera Nootropic agent, Novartis Nootropicagent, Santhera Omigapil Omigapil [INN] Omigapil) QLMMOGWZCFQAPU-UHFFFAOYSA-N SCHEMBL333032 SNT-317 TCH-346 TCH-346B TCH346 Tch 346 UNII-5V14HD0N4Q ZINC33943510 dibenz[b,f]oxepin-10-ylmethyl-N-methyl-N-prop-2-ynylamine dibenzo-(b,f)oxepin-10-ylmethyl-methyl-prop-2-ynyl-amine pubmed:29559585 chebi:CHEBI:35364 chebi:CHEBI:41778 chembl:CHEMBL1232111 chembl:CHEMBL3734823 drugbank:DB12879 inchi:InChI=1S/C19H17NO/c1-3-12-20(2)14-16-13-15-8-4-6-10-18(15)21-19-11-7-5-9-17(16)19/h1,4-11,13H,12,14H2,2H3 pubchem.compound:6419718 smiles:CN(CC#C)CC1=CC2=CC=CC=C2OC3=CC=CC=C31 orcid:0000-0001-9661-5277 A dual inhibitor of PDE5 and HDACs, chronic treatment of Tg2576 mice, a well characterized AD mouse model, showed decreased Ab and Tau phsophorylation and inhibition of GSK3B activity. CM-414 2-(4-morpholinylmethyl)-2-propenoic acid 2-(Morpholinomethyl)acrylic acid 2-(Morpholinomethyl)propenoic acid 2-(morpholin-4-ylmethyl)prop-2-enoic Acid 2-MORPHOLIN-4-YLMETHYL-ACRYLIC ACID 2-Morpholin4-ylmethyl-acrylic acid 2-[(morpholin-4-yl)methyl]prop-2-enoic acid 2-morpholin-4-ylmethyl-2-propenoic acid 2-morpholin-4ylmethyl-2-propenoic acid 4-Morpholinepropanoicacid, a-methylene- 4432-44-4 4868AH A826542 AB0085720 AB1552 AJ-96850 AKOS010054622 CM-414 CTK4I8112 DB-070534 DTXSID30439182 F9995-2550 FT-0718529 IGZSSKAOSOCVPH-UHFFFAOYSA-N K-8942 KB-106928 MCULE-2720405682 MFCD06208438 MolPort-019-997-392 SCHEMBL793684 ZINC38760485 pubmed:27550730 cas:4432-44-4 inchi:InChI=1S/C8H13NO3/c1-7(8(10)11)6-9-2-4-12-5-3-9/h1-6H2,(H,10,11) pubchem.compound:10397232 smiles:C=C(CN1CCOCC1)C(=O)O orcid:0000-0001-9661-5277 A structural motif of DAPK (Death-Associated Protein Kinase) positively regulating the kinase activity. DAPK, basic loop (BL) motif pubmed:27133022 orcid:0000-0001-9661-5277 One of the five main histone proteins of chromatin structure, acetylation at Lys 9 was positively linked with the transcriptional activation of various genes involved in neuro-regeneration following peripheral axonal injury, among which BDNF. Histone H3 pubmed:24686445 fplx:Histone_H3 orcid:0000-0001-9661-5277 Inhibitor of GSK3Beta and DYRK1 kinases ID-8 pubmed:28884684 orcid:0000-0001-9661-5277 A synthetic derviative of 2,4-diaminothiazole serving as an inhibitor of CDK5 kinase acitivty and of tau PHF1 epitope phosphorylation LDN-193594 (4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(2-fluorophenyl)methanone 1289638-15-8 BDBM50340902 CHEMBL1761791 KB-274259 NSC-747885 NSC747885 XHJMMMPXTUEBMQ-UHFFFAOYSA-N ZINC71317068 ldn-193594 pubmed:23737518 chembl:CHEMBL1761791 inchi:InChI=1S/C15H11FN4OS/c16-11-6-2-1-5-10(11)12(21)13-14(17)20-15(22-13)19-9-4-3-7-18-8-9/h1-8H,17H2,(H,19,20) pubchem.compound:54581340 smiles:C1=CC=C(C(=C1)C(=O)C2=C(N=C(S2)NC3=CN=CC=C3)N)F orcid:0000-0001-9661-5277 A synthetic derviative of 2,4-diaminothiazole with a lesser powerful inhibitory effect on CDK5, but a potent inhibitor of Gsk3b LDN-193665 pubmed:23737518 cas:1289638-16-9 inchi: InChI=1S/C15H11FN4OS/c16-10-4-1-3-9(7-10)12(21)13-14(17)20-15(22-13)19-11-5-2-6-18-8-11/h1-8H,17H2,(H,19,20) smiles:FC1=CC=CC(C(C2=C(N)N=C(NC3=CN=CC=C3)S2)=O)=C1 orcid:0000-0001-9661-5277 Small molecule of the diaminothiazole class, acting as inhibitor of CDK5 and GSK3Beta kinases LDN-213843 pubmed:23737518 inchi:InChI=1S/C19H19FN6OS/c20-14-4-2-1-3-13(14)16(27)17-18(21)25-19(28-17)24-12-5-6-15(23-11-12)26-9-7-22-8-10-26/h1-6,11,22H,7-10,21H2,(H,24,25) smiles:C1(=CC=CC=C1C(C4=C(N)N=C(NC2=CN=C(C=C2)N3CCNCC3)S4)=O)F orcid:0000-0001-9661-5277 A gradual weakening of neuronal synaptic connections lasting hours or longer following a long patterned stimulus. Along with LTP (long term potentiation) is one of the main mechanisms of memory formation, more specifically of spatial memory. The mechanism involves an interplay of NMDA and AMPA glutamate receptors, with minimal intracellular calcium levels triggering a cellular cascade leading to the removal of the latter and an overall decrease of the glutammate receptors in the postsynaptic neurons, thus weakening the synapse. Long-Term Depression pubmed:22833681 orcid:0000-0001-9661-5277 Pathological spreading pattern of tau into defined anatomycally interconnected brain regions during the progression of tauopathy. Pathological Tau Spreading pubmed:29540553 orcid:0000-0001-9661-5277 PrPSc (scrapie isoform of the prion protein) prions are the infectious agent behind diseases such as Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy in cattle, chronic wasting disease in cervids (deer, elk, moose, and reindeer), as well as goat and sheep scrapie. PrPSc is an alternatively folded variant of the cellular prion protein, PrPC, which is a regular, GPI-anchored protein that is present on the cell surface of neurons and other cell types. PrPSc pubmed:22692785 pubmed:29414853 uniprot:F7VJQ1 uniprot.isoform:F7VJQ1-1 orcid:0000-0001-9661-5277 A turn-like structure formed in tau as a conseguence of the phosphorylation of only Ser202 and Thr205 residues, protects against aggregation. Tau Protein Secondary Structure, Turn pubmed:28784767 orcid:0000-0001-9661-5277 RG7345 is a humanized monoclonal antibody targeting the tau phosphoepitope pS422. Tau phosphorylated at this site is considered a pathological form that has been linked to the relocalization of tau away from microtubules and toward the somato-dendritic compartment of the neuron. Tau antibody, RG7345 pubmed:26751493 pubmed:10967355 orcid:0000-0001-9661-5277 Selective inhibitor of HDAC3 RGFP966 (2E)-N-(2-amino-4-fluorophenyl)-3-{1-[(2E)-3-phenylprop-2-en-1-yl]-1H-pyrazol-4-yl}prop-2-enamide (E)-N-(2-amino-4-fluorophenyl)-3-(1-cinnamyl-1H-pyrazol-4-yl)acrylamide 1357389-11-7 1396841-57-8 2-Propenamide, N-(2-amino-4-fluorophenyl)-3-[1-[(2E)-3-phenyl-2-propen-1-yl]-1H-pyrazol-4-yl]-, (2E)- 2686AH A13218 AK676067 AKOS030526449 BC600495 BCP08102 BLVQHYHDYFTPDV-VCABWLAWSA-N C21H19FN4O CHEBI:131163 CHEMBL4078477 D00HXX DA-45384 DA-45706 EX-A229 GTPL7500 J-007305 KB-148638 MFCD26960954 MolPort-035-395-807 QC-11774 RGFP 966 RGFP-966 RGFP966 RGFP966 Racemate RGFP966, >=98% (HPLC) SB19284 SCHEMBL12497867 SCHEMBL12497871 SW219401-1 ZINC95616594 s7229 pubmed:28771976 chebi:CHEBI:131163 inchi:InChI=1S/C21H19FN4O/c22-18-9-10-20(19(23)13-18)25-21(27)11-8-17-14-24-26(15-17)12-4-7-16-5-2-1-3-6-16/h1-11,13-15H,12,23H2,(H,25,27)/b7-4+,11-8+ pubchem.compound:56650312 smiles:C1=CC=C(C=C1)C=CCN2C=C(C=N2)C=CC(=O)NC3=C(C=C(C=C3)F)N orcid:0000-0001-9661-5277 Inhibitor of MAP2K1/2 kinases activity in murine neuroblastoma cell line N2A SL-327 (2Z)-3-amino-3-[(4-aminophenyl)sulfanyl]-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile (Z)-3-amino-3-(4-aminophenylthio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile 3-amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile 3-amino-3-[(4-aminophenyl)sulfanyl]-2-[2-(trifluoromethyl)phenyl]acrylonitrile 3-amino-3-[(4-aminophenyl)thio]-2-[2-(trifluoromethyl)phenyl]-2-propenenitrile 305350-87-2 AKOS024456884 AOB5954 BC600460 BCP05310 BRD-K12244279-001-01-7 Benzeneacetonitrile, alpha-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)- CCG-206867 CHEBI:92211 CS-0910 D04WPA DTXSID90429549 E/Z-a-[amino[(4-aminophenyl)thio]methylen]-2-(trifluoromethyl)benzeneacetonitrile EC-000.2354 EX-A1069 GTPL6008 HMS3229K18 HMS3678M21 HSCI1_000044 HY-15437 J-018001 JLOXTZFYJNCPIS-FYWRMAATSA-N K00090 KB-80585 LS-193345 MEK1/2 Inhibitor MFCD06411432 MolPort-006-069-021 NCGC00092290-01 NCGC00092290-02 SB19419 SCHEMBL570317 SCHEMBL570318 SL 327 SL-327 SL327 SL327, >=98% (HPLC), Mixture of E & Z isomers, solid SW219839-1 W-5333 X3440 Z-& E-a-(Amino-((4-aminophenyl)thio)methylene)-2-(trifluoromethyl)benzeneacetonitrile Z-& E-alpha-(Amino-((4-aminophenyl)thio)methylene)-2-(trifluoromethyl)benzeneacetonitrile ZINC1910234 alpha-[Amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile alpha-{amino[(4-aminophenyl)thio]methylene}-2-(trifluoromethyl)benzeneacetonitrile s1066 pubmed:24401760 cas:305350-87-2 chebi:CHEBI:92211 inchi:InChI=1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+ pubchem.compound:9549284 smiles:C1=CC=C(C(=C1)C(=C(N)SC2=CC=C(C=C2)N)C#N)C(F)(F)F orcid:0000-0001-9661-5277 Spinocerebellar ataxia type 11 (SCA11) is characterized by progressive cerebellar ataxia and abnormal eye signs (jerky pursuit, horizontal and vertical nystagmus). Caused by mutations in the TTBK2 (Tau Tubulin Kinase 2) gene, is inherited in an autosomal dominant manner. Spinocerebellar Ataxia 11 pubmed:21548880 orcid:0000-0001-9661-5277 A thiol derivative, pan-HDAC inhibitor ST7612AA1 1428535-92-5 A14418 BDBM50027652 CHEMBL3353926 SB17083 SCHEMBL14812001 ST-7612AA1 Thioacetic acid S-[(S)-6-[[(R)-5-oxopyrrolidine-2-ylcarbonyl]amino]-6-(phenylcarbamoyl)hexyl] ester pubmed:27917100 chembl:CHEMBL3353926 inchi:InChI=1S/C20H27N3O4S/c1-14(24)28-13-7-3-6-10-16(19(26)21-15-8-4-2-5-9-15)23-20(27)17-11-12-18(25)22-17/h2,4-5,8-9,16-17H,3,6-7,10-13H2,1H3,(H,21,26)(H,22,25)(H,23,27)/t16-,17+/m0/s1 pubchem.compound:71538210 smiles:CC(=O)SCCCCC[C@H](NC(=O)[C@H]1CCC(=O)N1)C(=O)Nc2ccccc2 orcid:0000-0001-9661-5277 Rabbit polyclonal antibody against tau pSer262, AstraZeneca Tau antibody, AGG5759 pubmed:23666762 orcid:0000-0001-9661-5277 Tau epitope consisting of pThr396 and pSer404 Tau epitope, AD2 pubmed:11943212 orcid:0000-0001-9661-5277 Tau epitope consisting of pSer422 Tau epitope, AP422 pubmed:11943212 orcid:0000-0001-9661-5277 Tau epitope consisting of pSer214 and pThr212 Tau epitope, AT100 pubmed:22833681 orcid:0000-0001-9661-5277 Tau epitope consisting of pThr181 Tau epitope, AT270 pubmed:11943212 orcid:0000-0001-9661-5277 Inhibitor of O-GlcNAcase (OGA) Thiamet G (3aR)-2-(Ethylamino)-6beta,7alpha-dihydroxy-3aalpha,6,7,7aalpha-tetrahydro-5H-pyrano[3,2-d]thiazole-5alpha-methanol (3aR,5R,6S,7R,7aR)-2-(Ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol (3aR,5R,6S,7R,7aR)-2-(ethylamino)-5-(hydroxymethyl)-3a,6,7,7a-tetrahydro-5H-pyrano[3,2-d]thiazole-6,7-diol (3aR,5R,6S,7R,7aR)-2-(ethylamino)-5-(hydroxymethyl)-3aH,5H,6H,7H,7aH-pyrano[3,2-d][1,3]thiazole-6,7-diol 1,2-Dideoxy-2'-ethylamino-a-D-glucopyranoso-[2,1-d]-2'-thiazoline 1009816-48-1 2070AH 2754AH 5H-Pyrano[3,2-d]thiazole-6,7-diol, 2-(ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-, (3aR,5R,6S,7R,7aR)- ACN-038039 AKOS024458135 AOB5913 C9H16N2O4S EX-A2240 HMS3648I18 HY-12588 J-000295 MFCD15144964 NCGC00344096-03 SR-01000946377 SR-01000946377-1 SW219118-1 Thiamet G Thiamet G, >=98% (HPLC) Thiamet G;\n2-(ethylamino)-3aR,6S,7R,7aR-tetrahydro-5R-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol Thiamet-G W-200641 ZINC16052637 s7213 pubmed:22833681 chembl:CHEMBL1213603 inchi:InChI=1S/C9H16N2O4S/c1-2-10-9-11-5-7(14)6(13)4(3-12)15-8(5)16-9/h4-8,12-14H,2-3H2,1H3,(H,10,11)/t4-,5-,6-,7-,8-/m1/s1 pubchem.compound:24808478 smiles:CCNC1=NC2C(C(C(OC2S1)CO)O)O orcid:0000-0001-9661-5277 Dye binding to PHF used in AD diagnostics Thioflavin S pubmed:7667312 orcid:0000-0001-9661-5277 Chemical compound group of susbtrate competitive selective HDAC6 inhibitors Trithiocarbonates pubmed:18558669 orcid:0000-0001-9661-5277 Inhibitor of HDAC6 Tubacin pubmed:23487739 cas:537049-40-4 chebi:CHEBI:94166 inchi:InChI=1S/C41H43N3O7S/c45-26-28-17-19-29(20-18-28)35-25-34(27-52-41-43-38(30-11-5-3-6-12-30)39(51-41)31-13-7-4-8-14-31)49-40(50-35)32-21-23-33(24-22-32)42-36(46)15-9-1-2-10-16-37(47)44-48/h3-8,11-14,17-24,34-35,40,45,48H,1-2,9-10,15-16,25-27H2,(H,42,4 iupac:N1-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N8-hydroxy-octanediamide smiles:O=C(CCCCCCC(NO)=O)NC(C=C1)=CC=C1[C@@H]2O[C@H](C3=CC=C(CO)C=C3)C[C@H](CSC4=NC(C5=CC=CC=C5)=C(C6=CC=CC=C6)O4)O2 orcid:0000-0001-9661-5277 Inhibitor of HDAC6 shown to also decrease tau hyperphosphorylation and Ab load Tubastatin A pubmed:24844691 cas:1252003-15-8 chebi:CHEBI:94186 inchi:InChI=1S/C20H21N3O2/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25/h2-9,25H,10-13H2,1H3,(H,21,24) smiles:ONC(C1=CC=C(CN2C(CCN(C)C3)=C3C4=C2C=CC=C4)C=C1)=O orcid:0000-0001-9661-5277 Inhibitory oligopeptide of the USP14, a deubiquitinating enzyme. USP14 Aptamer pubmed:26041011 orcid:0000-0001-9661-5277 A neuron that uses acetylcholine as a vesicular neurotransmitter. cholinergic neuron pubmed:29221819 mesh:D059329 orcid:0000-0001-9661-5277 The thin layer of gray matter on the surface of the cerebral hemisphere that develops from the telencephalon. It consists of the neocortex (6 layered cortex or isocortex), the hippocampal formation and the olfactory cortex. cerebral cortex pubmed:29221819 mesh:D002540 orcid:0000-0001-9661-5277 Inhibitor of HDAC6 crebinostat pubmed:25546293 cas:1092061-61-4 inchi:InChI=1S/C20H23N3O3/c24-19(9-5-2-6-10-20(25)23-26)22-21-15-16-11-13-18(14-12-16)17-7-3-1-4-8-17/h1,3-4,7-8,11-15,26H,2,5-6,9-10H2,(H,22,24)(H,23,25)/b21-15+ smiles:C1=CC=CC(=C1)C2=CC=C(C=C2)C=NNC(CCCCCC(=O)NO)=O orcid:0000-0001-9661-5277 Compound class with kinase inhibition properties, specifically for CDK5 and GSK3Beta diaminothiazole pubmed:23737518 orcid:0000-0001-9661-5277 Layer of the entorhinal cortex lying superficial to layer 3 and deep to layer 1. It is characterized by medium-to large sized stellate cells that are grouped into prominent clusters, particularly in the rostral entorhinal cortex. entorhinal cortex layer 2 pubmed:27798139 orcid:0000-0001-9661-5277 The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. granular layer of cerebellar cortex pubmed:29221819 orcid:0000-0001-9661-5277 A powerful inhibitor of GSK3B indirubin pubmed:11013232 cas:479-41-4 chemspider:4477010 inchi:nChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13- smiles:c1ccc2c(c1)/C(=C/3\C(=O)c4ccccc4N3)/C(=O)N2 orcid:0000-0001-9661-5277 Inhibitor of tau aggregation isocarboxazide 1-Benzyl-2-(5-methyl-3-isoxazolyl-carbonyl)hydrazine 1-Benzyl-2-(5-methyl-3-isoxazolylcarbonyl)hydrazine 3-(2-BENZYLHYDRAZOCARBOXY)-5-METHYL-ISOXAZOLE 3-Isoxazolecarboxylic acid, 2-(phenylmethyl)hydrazide 3-Isoxazolecarboxylic acid, 2-benzylhydrazide 3-Isoxazolecarboxylic acid, 5-methyl-, 2-(phenylmethyl)hydrazide 3-Isoxazolecarboxylic acid, 5-methyl-, 2-benzylhydrazide 34237V843T 4-27-00-03999 (Beilstein Handbook Reference) 5-Methyl-3-isoxazolecarboxylic acid 2-benzylhydrazide 5-methyl-N'-(phenylmethyl)-3-isoxazolecarbohydrazide 5-methyl-N'-(phenylmethyl)isoxazole-3-carbohydrazide 59-63-2 AB00513923 AC-24841 AC1L1GNE AJ-08053 AKOS016003091 ANW-58213 API0000611 AX8135097 BC645218 BDBM163692 BMIH BPBio1_001024 BRD-K93332168-001-03-2 BRN 0201295 BSPBio_000930 Benazide CAS-59-63-2 CCG-220795 CCRIS 9178 CHEBI:93635 CHEMBL1201168 CS-0008613 CTK8B7692 D02580 D0I2VK DB01247 DSSTox_CID_3171 DSSTox_GSID_23171 DSSTox_RID_76902 DTXSID4023171 EINECS 200-438-4 Enerzer FCH2716017 FT-0670438 GTPL7204 HMS1570O12 HMS2097O12 HMS2230E11 HMS3369G18 HMS3714O12 HY-13929 ISOCARBOXAZID (200 MG) Isocarbonazid Isocarbossazide Isocarbossazide [DCIT] Isocarboxazid (ICD) Isocarboxazid (INN) Isocarboxazid 5-methyl-3-isoxazole-carboxylic acid 2-benzylhydrazide, AldrichCPR Isocarboxazid [INN:BAN] Isocarboxazid [USP:INN:BAN] Isocarboxazida Isocarboxazida [INN-Spanish] Isocarboxazide Isocarboxazide [INN-French] Isocarboxazidum Isocarboxazidum [INN-Latin] Isocarboxizid Isocarboxyzid KB-258619 LS-86607 MLS002154005 MLS003106729 Maraplan Marplan Marplan (TN) Marplon N'-Benzyl N-methyl-5-isoxazolecarboxylhydrazide-3 N'-Benzyl-5-methyl-3-isoxazolecarbohydrazide # N'-Benzyl-5-methylisoxazole-3-carbohydrazide N'-benzyl-5-methyl-1,2-oxazole-3-carbohydrazide NCGC00016267-01 NCGC00016267-02 NCGC00016267-03 NSC 169893 NSC-169893 NSC169893 Prestwick0_000795 Prestwick1_000795 Prestwick2_000795 Prestwick3_000795 Ro 5-0831 Ro 5-0831/1 Ro5-0831 SCHEMBL49562 SMR001233334 SPBio_002869 SR-01000841192 SR-01000841192-2 SR-01000841192-3 TC-146958 Tox21_110336 UNII-34237V843T WLN: T5NOJ C1 EVMM1R XKFPYPQQHFEXRZ-UHFFFAOYSA-N Y0484 ZINC1587 isocarboxazid pubmed:26751493 chebi:CHEBI:93635 chembl:CHEMBL1201168 drugbank:DB01247 inchi:InChI=1S/C12H13N3O2/c1-9-7-11(15-17-9)12(16)14-13-8-10-5-3-2-4-6-10/h2-7,13H,8H2,1H3,(H,14,16) pubchem.compound:3759 smiles:CC1=CC(=NO1)C(=O)NNCC1=CC=CC=C1 orcid:0000-0001-9661-5277 Inhibitor of CKD5 activity isopentanyladenine (3-methyl-but-2-enyl)-(7(9)H-purin-6-yl)-amine (3-methylbut-2-enyl)purin-6-ylamine 13255-47-5 1H-Purin-6-amine, N-(3-methyl-2-butenyl)- 1H-Purin-6-amine, N-(3-methyl-2-butenyl)- (9CI) 2365-40-4 2exm 3-methylbut-2-enyl(7H-purin-6-yl)amine 365I404 5122-37-2 6-((3-Methyl-2-butenyl)amino)purine 6-(.gamma.,.gamma.-Dimethylallylamino)purine 6-(3,3-DIMETHYLALLYLAMINO)PURINE 6-(3-methyl-2-buten-1-ylamino)purine 6-(gamma,gamma-DIMETHYLALLYLAMINO) PURINE 6-(gamma,gamma-Dimethylallylamino)purine 6-(gamma,gamma-Dimethylallylamino)purine, BioReagent, plant cell culture tested, 1 mg/mL 6-(gamma,gamma-Dimethylallylamino)purine, BioReagent, plant cell culture tested, >=90% 6-(gamma,gamma-Dimethylallylamino)purine, BioReagent, plant cell culture tested, >=98.5% 6-(gamma,gamma-Dimethylallylamino)purine, Vetec(TM) reagent grade, >=98.5% 6-(|A,|A-Dimethylallylamino)purine 6-[(3-Methyl-2-butenyl)amino]purine 6-[(3-methylbut-2-en-1-yl)amino]purine A816825 AC-15608 AC1L3NL1 ACM2365404 AK163607 AKOS005257639 AKOS015914857 AKOS028109417 AN-50750 AS-17517 AX8017021 Adenine, N-(3-methyl-2-butenyl)- Adenine, N-(3-methyl-2-butenyl)- (8CI) BC209320 BID525 BRD-K62158429-001-01-7 C04083 CCG-38046 CHEBI:17660 CHEMBL476189 CI-027 CS-0043352 CTK8G1492 D-4760 D0I1SZ DB08768 DTXSID10178325 Dimethylallyladenine EBD28940 Enadenine FT-0629731 HMS1543F03 HY-112103 HYVABZIGRDEKCD-UHFFFAOYSA-N I14-7114 IPADE Isopentenyl adenine Isopentenyladenine KB-57456 LS-184209 MCULE-6781114249 MFCD00132998 MolPort-002-511-573 N(6)-(.DELTA.2-Isopentenyl)aminopurine N(6)-(Delta2-isopentenyl)adenine N(6)-(delta(2)-Isopentenyl)adenine N(6)-dimethylallyladenine N-(.DELTA.2-Isopentenyl)adenine N-(.gamma.,.gamma.-Dimethylallyl)adenine N-(3-METHYLBUT-2-EN-1-YL)-9H-PURIN-6-AMINE N-(3-Methyl-2-butenyl)-1H-purin-6-amine N-(3-Methyl-2-butenyl)-1H-purin-6-amine # N-(3-Methyl-2-butenyl)adenine N-(3-methyl-2-butenyl)-9H-purin-6-amine N-(3-methylbut-2-en-1-yl)-7H-purin-6-amine N-(3-methylbut-2-enyl)-7H-purin-6-amine N-(3-methylbut-2-enyl)-9H-purin-6-amine N-(delta2-Isopentenyl)adenine N-(gamma,gamma-Dimethylallyl)adenine N-6-(3,3-Dimethylallyl)adenine N-6-(delta2-Isopentenyl)-adenine N6 -(Delta2 -Isopentenyl)adenine N6-(.DELTA.2-Isopentenyl)adenine N6-(.DELTA.2-Isopentenyl)aminopurine N6-(2-Isopentenyl)-adenine N6-(2-Isopentenyl)adenine N6-(3-Methyl-2-butenyl)adenine N6-(3-Methylbut-2-enyl)adenine N6-(delta 2-Isopentenyl)-adenine N6-(delta2-Isopentenyl)-adenine N6-(delta2-Isopentenyl)adenine N6-(delta2-Isopentenyl)aminopurine N6-.DELTA.2-Isopentenyl)adenine N6-Delta2-isopentenyladenine N6-Dimethylallyladenine N6-Isopentenyladenine NCGC00014084 NCGC00014084-02 NCGC00097193-01 NCI106958 NCI60_000165 NCIStruc1_000935 NCIStruc2_000921 NSC 106958 NSC-106958 NSC106958 Oprea1_344117 SC-18768 SCHEMBL459276 ST044513 ST24048354 TimTec1_003281 UNII-V500BB256Z V0538 V500BB256Z ZB000921 ZINC32351 ZX-AFC000343 isopentenyl-adenine n-isopentenyladenine pubmed:8726973 chebi:CHEBI:17660 drugbank:DB08768 inchi:InChI=1S/C10H13N5/c1-7(2)3-4-11-9-8-10(13-5-12-8)15-6-14-9/h3,5-6H,4H2,1-2H3,(H2,11,12,13,14,15) pubchem.compound:92180 smiles:CC(=CCNC1=NC=NC2=C1NC=N2)C orcid:0000-0001-9661-5277 Increases intracellular calcium levels, and induces the association of TGM2 with tau, positively affecting the activity of the former maitotoxin 9P59GES78D CHEMBL2152261 HSDB 7753 Maitotoxin Maitotoxin 1 UNII-9P59GES78D pubmed:10537045 cas:59392-53-9 chembl:ChEMBL2152261 chemspider:25991548 inchi:InChI=1S/C164H258O68S2.2Na/c1-24-26-65(2)68(5)41-74(168)117(179)85-33-36-152(11)106(203-85)55-109-162(21,231-152)64-161(20)105(210-109)51-89-83(220-161)28-25-27-82-99(199-89)59-157(16)108(202-82)56-107-153(12,230-157)39-38-151(10)112(211-107)61-158(17)111(224-151)54-101(176)163(22,232-158)103-32-31-84-90(204-103)53-110-156(15,219-84)62-113-150(9,223-110)37-34-102-155(14,225-113)63-114-164(23,227-102)147(192)149-159(18,226-114)58-81(175)134(218-149)133-79(173)47-93-136(216-133)120(182)119(181)92(200-93)44-72(166)43-76(170)131-77(171)46-94-137(214-131)122(184)124(186)143(207-94)145-126(188)125(187)144-146(217-145)128(190)139-97(208-144)50-88-87(206-139)49-96-138(205-88)127(189)141(229-234(196,197)198)95(201-96)45-75(169)118(180)132-78(172)48-98-140(215-132)129(191)148-160(19,221-98)60-100-91(209-148)52-104-154(13,222-100)57-80(174)135-142(212-104)123(185)121(183)130(213-135)71(8)115(177)67(4)29-30-86(228-233(193,194)195)116(178)69(6)42-73(167)70(7)66(3)35-40-165;;/h24-25,28,35,65,67-69,71-149,165-192H,1,7,26-27,29-34,36-64H2,2-6,8-23H3,(H,193,194,195)(H,196,197,198);;/q;2*+1/p-2/b28-25-,66-35+;;/t65-,67+,68+,69+,71+,72+,73+,74+,75-,76+,77+,78+,79+,80+,81+,82+,83-,84+,85-,86-,87-,88+,89+,90-,91-,92-,93-,94-,95-,96+,97-,98+,99-,100+,101+,102+,103-,104+,105-,106-,107+,108-,109+,110+,111-,112-,113+,114+,115+,116+,117-,118+,119-,120+,121+,122+,123-,124+,125+,126+,127+,128+,129-,130-,131-,132-,133+,134+,135+,136+,137+,138+,139-,140+,141-,142-,143+,144-,145+,146+,147-,148+,149+,150-,151+,152+,153-,154-,155-,156-,157+,158+,159-,160-,161+,162-,163+,164+;;/m0../s1 pubchem.compound:71460273 smiles:C[C@H](CC[C@@H]([C@@H]([C@H](C)C[C@H](C(=C)/C(=C/CO)/C)O)O)OS(=O)(=O)[O-])[C@H]([C@@H](C)[C@H]1[C@@H]([C@@H]([C@H]2[C@H](O1)[C@@H](C[C@]3([C@H](O2)C[C@H]4[C@H](O3)C[C@]5([C@H](O4)[C@H]([C@H]6[C@H](O5)C[C@H]([C@H](O6)[C@@H]([C@H](C[C@H]7[C@@H]([C@@H]([C@H]8[C@H](O7)C[C@H]9[C@H](O8)C[C@H]1[C@H](O9)[C@H]([C@@H]2[C@@H](O1)[C@@H]([C@H]([C@@H](O2)[C@H]1[C@@H]([C@H]([C@H]2[C@@H](O1)C[C@H]([C@@H](O2)[C@@H](C[C@H](C[C@H]1[C@@H]([C@H]([C@H]2[C@@H](O1)C[C@H]([C@@H](O2)[C@H]1[C@@H](C[C@]2([C@H](O1)[C@@H]([C@]1([C@H](O2)C[C@]2([C@H](O1)CC[C@]1([C@H](O2)C[C@]2([C@H](O1)C[C@H]1[C@H](O2)CC[C@H](O1)[C@]1([C@@H](C[C@H]2[C@](O1)(C[C@H]1[C@](O2)(CC[C@]2([C@H](O1)C[C@H]1[C@](O2)(C[C@H]2[C@H](O1)C/C=C\[C@H]1[C@H](O2)C[C@H]2[C@](O1)(C[C@]1([C@H](O2)C[C@H]2[C@](O1)(CC[C@H](O2)[C@H]([C@@H](C[C@@H](C)[C@@H](C)CC=C)O)O)C)C)C)C)C)C)C)O)C)C)C)C)C)O)C)O)O)O)O)O)O)O)O)O)O)O)O)O)OS(=O)(=O)[O-])O)O)O)O)C)C)O)O)O)O.[Na+].[Na+] orcid:0000-0001-9661-5277 Inhibitor of CKD5 activity olomoucine 101622-51-9 1966AH 1w0x 2,6,9-Trisubstituted purine deriv. 26 2-(2-Hydroxyethylamino)-6-(benzylamino)-9-methylpurine 2-(2-Hydroxyethylamino)-6-benzylamino-9-isopropylpurine 2-(2-Hydroxyethylamino)-6-benzylamino-9-methylpurine 2-(6-(benzylamino)-9-methyl-9H-purin-2-ylamino)ethanol 2-(Hydroxyethylamino)-6-benzylamino-9-methylpurine 2-({9-methyl-6-[benzylamino]purin-2-yl}amino)ethan-1-ol 2-[[6-(benzylamino)-9-methyl-purin-2-yl]amino]ethanol 2-[[6-(benzylamino)-9-methylpurin-2-yl]amino]ethanol 2-[[9-Methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-ethanol 2-[[9-Methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]ethanol 2-[[9-Methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]ethanol, 9CI 2-[[9-methyl-6-(phenylmethylamino)purin-2-yl]amino]ethanol 2-{[6-(benzylamino)-9-methyl-9H-purin-2-yl]amino}ethan-1-ol 2-{[6-(benzylamino)-9-methyl-9h-purin-2-yl]amino}ethanol 4erk 6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine 6-(benzylamino)-2-[(2-hydroxyethyl)amino]-9-methylpurine 6-Benylamino-2-(2-hydroxyethylamino)-9-methylpurine 6-Benzylamino-2-(2-hydroxyethylamino)-9-methylpurine 6-benzylamino-2-[2-hydroxyethylamino]-9-methylpurine 6A839B2HYS AC1L1IID AC1Q4XZU ACMC-20cp0o AKOS005145988 BCBcMAP01_000205 BDBM5718 BIO3107 BMK1-E10 BRD-K82731415-001-03-9 BRD-K82731415-001-04-7 BSPBio_000990 Bio1_000336 Bio1_000825 Bio1_001314 Bio2_000335 Bio2_000815 BiomolKI2_000052 BiomolKI_000046 C-28477 C15H18N6O CBiol_002050 CCG-100650 CHEMBL280074 CJ-26517 CTK4A0020 D00BPA DB02116 DTXSID90144068 EU-0100883 Ethanol, 2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]- Ethanol,2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]- FT-0642456 GTVPOLSIJWJJNY-UHFFFAOYSA-N HMS1362B11 HMS1792B11 HMS1990B11 HMS3262B08 HMS3267L09 HMS3403B11 HMS3650F19 HMS3676E10 IDI1_002090 IN1179 IN1182 InSolution™ Olomoucine J-000453 KB-162429 KBio2_000330 KBio2_002898 KBio2_005466 KBio3_000659 KBio3_000660 KBioGR_000330 KBioSS_000330 Kinome_2870 LP00883 Lopac-O-0886 Lopac0_000883 MFCD00189360 MolPort-003-849-700 NCGC00015763-01 NCGC00015763-02 NCGC00015763-03 NCGC00015763-04 NCGC00015763-05 NCGC00015763-06 NCGC00015763-07 NCGC00015763-08 NCGC00015763-09 NCGC00025096-01 NCGC00025096-02 NCGC00025096-03 NCGC00025096-04 NCGC00025096-05 NCGC00025096-06 NCGC00025096-07 NCGC00261568-01 NCI60_022916 NSC 666096 NSC-666096 NSC666096 O 0886 OLO Olomoucine, >=98% (HPLC) Olomucine RT-014854 SCHEMBL135056 SMP1_000281 SR-01000075518 SR-01000075518-1 SR-01000075518-3 SR-01000075518-6 ST50298830 TRA0035611 Tocris-1284 Tox21_500883 UNII-6A839B2HYS UPCMLD-DP136 UPCMLD-DP136:001 UPCMLD-DP136:002 ZINC1641925 ZX-AFC001655 olomoucine purine deriv. 5 pubmed:8726973 chebi:CHEBI:44661 drugbank:DB02116 inchi:InChI=1S/C15H18N6O/c1-21-10-18-12-13(17-9-11-5-3-2-4-6-11)19-15(16-7-8-22)20-14(12)21/h2-6,10,22H,7-9H2,1H3,(H2,16,17,19,20) pubchem.compound:4592 smiles:CN1C=NC2=C1N=C(NCCO)N=C2NCC1=CC=CC=C1 orcid:0000-0001-9661-5277 Inhibitor of tau aggregation oxazolidinedione 1,3-oxazolidin-2,4-dione 1,3-oxazolidine-2,4-dione 12770-97-7 153301-EP2281822A1 1572AB 2,4-Oxazolidenedione 2,4-Oxazolidinedione 2,4oxazolidinedione 2346-26-1 346O261 A816734 AC1L3YF0 AJ-30743 AK-80133 AKOS002529400 AN-50728 ANW-57979 CJ-28984 CMLDBU00003511 COWNFYYYZFRNOY-UHFFFAOYSA-N CTK0H9315 DA-18172 DS-15871 F2167-1227 FT-0704394 KB-67472 KS-00000MOC MFCD02691902 MolPort-018-280-326 NSC 120350 NSC-120350 NSC120350 OXAZOLIDINE-2,4-DIONE Oxazolidinedione R22D15229R SC-49693 SCHEMBL123971 SCHEMBL1395587 SCHEMBL8159833 TC-146724 UNII-R22D15229R Z56762271 ZINC1709820 hydroxyoxazolinone pubmed:26751493 inchi:InChI=1S/C3H3NO3/c5-2-1-7-3(6)4-2/h1H2,(H,4,5,6) pubchem.compound:97389 smiles:C1C(=O)NC(=O)O1 orcid:0000-0001-9661-5277 Inhibitor of tau aggregation sudoxicam (3E)-3-[hydroxy-(1,3-thiazol-2-ylamino)methylidene]-2-methyl-1,1-dioxo-1 (3Z)-3-[hydroxy-(1,3-thiazol-2-ylamino)methylidene]-2-methyl-1,1-dioxo-1 2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-thiazolyl-, 1,1-dioxide 3-[hydroxy-(1,3-thiazol-2-ylamino)methylidene]-2-methyl-1,1-dioxo-1 34042-85-8 4-Hydroxy-2-methyl-N-(1,3-thiazol-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide 4-Hydroxy-2-methyl-N-1,3-thiazol-2-yl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide 4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide 4-hydroxy-2-methyl-1,1-dioxo-N-thiazol-2-yl-1$l^{6},2-benzothiazine-3-carboxamide 4-hydroxy-2-methyl-N-(2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide AC1L1W79 AC1NSEW2 AC1NSM46 ACM34042858 AKOS030239604 BRN 0628704 CHEMBL20634 CP 15973 CP-15,973 CP-15973 CTK8G3246 D05937 DTXSID50187653 EINECS 251-808-7 FT-0674694 J-019435 LS-40541 MLS006010801 N-(2-Thiazolyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-Dioxide NSC 615046 NSC-615046 NSC615046 Oprea1_704902 SCHEMBL35067 SCHEMBL35068 SMR004701482 SUDOXICAM SYCHUQUJURZQMO-UHFFFAOYSA-N Sudoxicam (USAN/INN) Sudoxicam [USAN:BAN:INN] Sudoxicam [USAN:INN:BAN] Sudoxicamum Sudoxicamum [INN-Latin] UNII-X033PDI962 X033PDI962 ZINC5699183 pubmed:26751493 cas:34042-85-8 inchi:InChI=1S/C13H11N3O4S2/c1-16-10(12(18)15-13-14-6-7-21-13)11(17)8-4-2-3-5-9(8)22(16,19)20/h2-7,17H,1H3,(H,14,15,18) pubchem.compound:54682951 smiles:CN1C(=C(C2=CC=CC=C2S1(=O)=O)O)C(=O)NC3=NC=CS3 orcid:0000-0001-9661-5277 Inhibitor of tau aggregation thiohydantoin pubmed:26751493 chembl:CHEMBL1958109 chemspider:1069421 inchi:InChI=1S/C3H4N2OS/c6-2-1-4-3(7)5-2/h1H2,(H2,4,5,6,7) smiles:O=C1CNC(=S)N1 orcid:0000-0001-9661-5277 Inhibitor of tau aggregation thioxooxazolidine pubmed:26751493 orcid:0000-0001-9661-5277 Irreversibly inhibits GSK3B activity tideglusib 1,2,4-Thiadiazolidine-3,5-dione, 2-(1-naphthalenyl)-4-(phenylmethyl)- 4-Benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione 4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione 4-benzyl-2-(naphthalen-1-yl)-(1,2,4)thiadiazolidine-3,5-dione 4-benzyl-2-naphthalen-1-yl-1,2,4-thiadiazolidine-3,5-dione 4CA-1249 865854-05-3 AK176015 AKOS025149085 AOB5562 BC600768 BCP06016 BDBM50166940 C19H14N2O2S CHEMBL3545157 CS-0613 D0UT7X DA-41071 DB12129 DTXSID90235682 EX-A600 FT-0700382 GTPL6929 HY-14872 J-514478 KB-81154 MFCD18633296 MolPort-028-599-952 NP 031112 NP-031112 NP-031112|||4-Benzyl-2-naphthalen-1-yl-1,2,4-thiadiazolidine-3,5-dione NP-12 NP031112 Q747Y6TT42 RL05359 SB19268 SCHEMBL676929 Tideglusib Tideglusib (NP031112, NP-12) Tideglusib [INN] Tideglusib(NP-031112) Tideglusib, >=98% (HPLC) Tideglusib,CAS:865854-05-3 UNII-Q747Y6TT42 W-5777 X5395 ZINC13985228 s2823 pubmed:22102280 inchi:InChI=1S/C19H14N2O2S/c22-18-20(13-14-7-2-1-3-8-14)19(23)24-21(18)17-12-6-10-15-9-4-5-11-16(15)17/h1-12H,13H2 pubchem.compound:11313622 smiles:O=C3SN(c1cccc2c1cccc2)C(=O)N3Cc4ccccc4 orcid:0000-0001-9661-5277 human monoclonal antibody that targets tau epitope 125-131 Tau antibody, 6C5 pubmed:28408124 orcid:0000-0002-3034-9970 mouse monoclonal antibody that targets tau epitope 159-163 Tau antibody, HT7 pubmed:28408124 orcid:0000-0002-3034-9970 During synthesis the HS chains are selectively sulfated at the N, 6-O, and 3-O positions of the glucosamine (GlcNS) and at the 2-O position of the uronic acid residue by HS sulfotransferases and modified by C5-epimerization of glucuronic acid (GlcA) to iduronic acid (IdoA) 6-O-sulfated heparin pubmed:24878958 orcid:0000-0002-6117-4413 During synthesis the HS chains are selectively sulfated at the N, 6-O, and 3-O positions of the glucosamine (GlcNS) and at the 2-O position of the uronic acid residue by HS sulfotransferases and modified by C5-epimerization of glucuronic acid (GlcA) to iduronic acid (IdoA) 2-O-sulfated heparin pubmed:24878958 orcid:0000-0002-6117-4413 To make sonicated fibril samples, fibrillized protein was sonicated using a MiSonix Sonicator 4000 (QSonica, LLC) at 50% amplitude for 60 1 s pulses sonicated tau fibrils pubmed:29686391 orcid:0000-0002-6117-4413 human monoclonal antibody that targets tau epitope 195-212 (pS202 and pT205) Tau antibody, 40E8 pubmed:28408124 orcid:0000-0002-3034-9970 rabbit polyclonal antibody that targets tau pS396 Tau antibody, pS396 pubmed:28408124 orcid:0000-0002-3034-9970 human monoclonal antibody that targets tau epitope 385-395 Tau antibody, 4E4 pubmed:28408124 orcid:0000-0002-3034-9970 mouse monoclonal antibody that targets tau epitope 404-441 Tau antibody, Tau46 pubmed:28408124 orcid:0000-0002-3034-9970 The cis conformation of phosphorylated tau is considered to be the main pathogenic tau agent associated with AD neurological impairments. PIN1, a peptidyl-prolyl-cis-transe isomerase, catalizes the rotation of the peptidic bond directly before proline residues inducing a conversion toward the trans conformation, therefore reducing the presence of the pathogenic cis tau isomers. cis p-tau pubmed:23157676 pubmed:25628064 orcid:0000-0001-9661-5277 MPT0G211 is a novel potent, selective HDAC6 inhibitor with IC50 of 0.291 nM, displays >1,000-fold selectivity over other HDAC isoforms; significantly inhibits tau phosphorylation on Ser396, Ser404, and phosphorylated tau (p-tau) aggregation, significantly attenuates apoptosis induced by p-tau, inhibits HDAC6/Hsp90 binding and causes subsequent proteasomal degradation of polyubiquitinated proteins; ameliorates learning and memory impairment in animal models of Alzheimer's disease, reduces the amount of phosphorylated tau in the hippocampal CA1 region; also demonstrates antiproliferative activity against human multiple myeloma RPMI 8226, U266, and NCI-H929 cells with no effect on normal bone marrow cells. MPT0G211 pubmed:29844403 cas:2151853-97-1 inchi:InChI=1S/C17H15N3O2/c21-17(20-22)14-8-6-12(7-9-14)11-19-15-5-1-3-13-4-2-10-18-16(13)15/h1-10,19,22H,11H2,(H,20,21) smiles:C1=CC(=CC=C1CNC2=CC=CC3=C2N=CC=C3)C(=O)NC orcid:0000-0001-9661-5277 PNS injuries initiate a signaling cascade that induces neuroregeneration. This cascade involves activation of ERK, subsequently leading to the activation of PCAF (KAT2B), which in turn mediates histone 3 acetylation, paving the way for transcriptional activation of the key genes in the regeneration program. peripheral nervous system injury pubmed:24686445 orcid:0000-0001-9661-5277 Murine monoclonal IgG recognizing the phosphatase-activating domain (PAD) of tau Tau antibody, TNT1 pubmed:27260838 orcid:0000-0001-9661-5277 Murine monoclonal IgG recognizing the phosphatase-activating domain (PAD) of tau Tau antibody, TNT2 pubmed:27260838 orcid:0000-0001-9661-5277 One of the major endogenus cGMP derivatives, a class of second messengers in the nitric oxide signalling pathway. It modifies the target protein's cysteine residues via a stable sulfide bond through the NO group of the guanine base, in a post translational modification also known as S-guanylation, a process involved in the regulation of the physiological roles of several important proteins. The S-guanylation of tau was shown to block the aggregation process and the subsequent formation of tau oligomers. 8-nitro-cGMP pubmed:27601475 pubmed:28213625 chebi:CHEBI:136665 inchi:InChI=1S/C10H11N6O9P/c11-9-13-6-3(7(18)14-9)12-10(16(19)20)15(6)8-4(17)5-2(24-8)1-23-26(21,22)25-5/h2,4-5,8,17H,1H2,(H,21,22)(H3,11,13,14,18)/t2-,4-,5-,8-/m1/s1 smiles:N1C(=NC2=C(N=C(N2[C@@H]3O[C@@H]4COP(O[C@H]4[C@H]3O)(=O)O)[N+]([O-])=O)C1=O)N orcid:0000-0001-9661-5277 A key intermediate product of tau oligomerization to PHF and NFT formation, they consist of covalently linked antiparallel tau monomers presenting disulfide cross links between cystein residues. Tau dimers pubmed:10899437 pubmed:27373205 orcid:0000-0001-9661-5277 A post-translational modification consisting on the addition and covalent bonding of multiple SUMO (small ubiquitin-like modifiers) proteins to lysine residues of target proteins, mediating a wide range of physiological functions. Polysumoylation of APP was found to reduce the generation of amyloid beta peptides, while mono or under-sumoylation enhance Ab generation. polysumoylation pubmed:12506199 orcid:0000-0001-9661-5277 Detyrosination is a form of posttranslational modification that occurs on alpha-tubulin. It consists of the removal of the C-terminal tyrosine to expose a glutamate at the newly formed C-terminus. detyrosination pubmed:25974414 orcid:0000-0001-9661-5277 Antibodies for the Tau protein (HGNC:MAPT) Tau antibody pubmed:23666762 pubmed:28408124 pubmed:26751493 pubmed:27260838 orcid:0000-0003-4423-4370 Epitopes targed by antibodies for the Tau protein (HGNC:MAPT) Tau epitope pubmed:23666762 pubmed:28408124 pubmed:26751493 pubmed:27260838 orcid:0000-0003-4423-4370 A partial agonist at α7 nAChR S 24795 2-[2-(4-Bromophenyl)-2-oxoethyl]-1-methylpyridinium iodide 2-[2-(4-bromophenyl)-2-oxoethyl]-1-methylpyridiniumiodide 304679-75-2 AKOS024457657 API0014115 KB-80442 LERUHBBUGAOYOD-UHFFFAOYSA-M MolPort-023-276-831 S 24795 S 24795, >=98% (HPLC) SCHEMBL5948853 pubmed:18187166 pubmed:18265960 pubmed:18034231 chemspider:8063920 inchi:InChI=1S/C14H13BrNO.HI/c1-16-9-3-2-4-13(16)10-14(17)11-5-7-12(15)8-6-11;/h2-9H,10H2,1H3;1H/q+1;/p-1 pubchem.compound:9888248 smiles:C[N+]1=CC=CC=C1CC(=O)C2=CC=C(C=C2)Br.[I-] orcid:0000-0003-4423-4370 GTS-21 is a derivative of the natural product anabaseine that acts as a partial agonist at neural nicotinic acetylcholine receptors. It binds to both the α4β2 and α7 subtypes, but activates only the α7 to any significant extent. GTS-21 (3E)-3-(2,4-dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine (3E)-3-[(2,4-DIMETHOXYPHENYL)METHYLIDENE]-3,4,5,6-TETRAHYDRO-2,3''-BIPYRIDINE (3e)-3-[(2,4-Dimethoxyphenyl)methylidene]-3,4,5,6-Tetrahydro-2,3'-Bipyridine 148372-04-7 2,3'-Bipyridine, 3-((2,4-dimethoxyphenyl)methylene)-3,4,5,6-tetrahydro-, (3E)- 2,3'-Bipyridine, 3-[(2,4-dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-, hydrochloride (1:2), (3E)- 2,4-Dimethoxybenzylidene anabaseine 2wnj 3 (2,4 dimethoxybenzylidene)anabaseine 3,4,5,6-Tetrahydro-3-(2,4-dimethoxybenzylidene)-2,3'-bipyridine 3-(2,4-Dimethoxy-benzylidene)-3,4,5,6-tetrahydro-[2,3']bipyridinyl 3-(2,4-Dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine 3-(2,4-dimethoxybenzylidene)anabaseine 3-(3-(2,4-dimethoxybenzylidene)-3,4,5,6-tetrahydropyridin-2-yl)pyridine 3-(4-hydroxy-2-methoxybenzylidene)anabaseine 3-[(2,4-dimethoxy)benzylidene]-anabaseine 3-[(2,4-dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-2,3'-Bipyridine 3-[(3E)-3-[(2,4-DIMETHOXYPHENYL)METHYLIDENE]-5,6-DIHYDRO-4H-PYRIDIN-2-YL]PYRIDINE 3-[(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-3,4,5,6-tetrahydropyridin-2-yl]pyridine 3-[(5E)-5-[(2,4-dimethoxyphenyl)methylidene]-3,4-dihydro-2H-pyridin-6-yl]pyridine 3-[(E)-(2,4-Dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-2,3'-bipyridine 3-[1-(2,4-Dimethoxy-phenyl)-meth-(E)-ylidene]-3,4,5,6-tetrahydro-[2,3'']bipyridinyl 419A471 8S399XDN2K A15950 AC1NSJRW AKOS005146470 ASIS-0106 BBL035625 BDBM50061564 BDBM86543 C19905 CAS_156223-05-1 CHEMBL134713 DB05708 DMXB-A Dimethoxybenzylidene anabaseine GTS 21 GTS-21 Gts-21 KB-77635 MolPort-004-975-791 NSC_122225 SCHEMBL316745 SCHEMBL316746 STL441849 UNII-8S399XDN2K X5074 X5075 ZINC860 pubmed:25514383 chemspider:4470526 drugbank:DB05708 inchi:InChI=1S/C19H20N2O2/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16/h3,6-9,11-13H,4-5,10H2,1-2H3/b15-11+ pubchem.compound:5310985 smiles:[H]\C(=C1\CCCN=C1C1=CN=CC=C1)C1=C(OC)C=C(OC)C=C1 orcid:0000-0003-4423-4370 nAChR subtype found in cortex, hippocampus and neostriatum alpha-4 alpha-5 beta-2 nAChR pubmed:19721446 orcid:0000-0002-3034-9970 complex(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2)) nAChR subtype found in hippocampus, pineal gland and cerebellum alpha-3 beta-4 nAChR pubmed:19721446 orcid:0000-0002-3034-9970 complex(p(HGNC:CHRNA3), p(HGNC:CHRNB4)) nAChR subtype found in habenula and interpeduncular nucleus alpha-3 beta-3 beta-4 nAChR pubmed:19721446 orcid:0000-0002-3034-9970 nAChR subtype found in locus coeruleus, substantia nigra and neostriatum alpha-6 beta-2 beta-3 nAChR pubmed:19721446 orcid:0000-0002-3034-9970 nAChR subtype found in interpeduncular nucleus alpha-2 beta-2 nAChR pubmed:19721446 orcid:0000-0002-3034-9970 nAChR subtype found in neostriatum alpha-6 alpha-4 beta-2 beta-3 nAChR pubmed:19721446 orcid:0000-0002-3034-9970 Protein aggregation occurs in vivo as a result of improper folding or misfolding protein aggregation pubmed:11831622 orcid:0000-0002-6117-4413 the process of assembling a receptor pentamer from the Nicotinic acetylcholine receptors subunits nAChR assembly pubmed:19126755 orcid:0000-0002-3034-9970 A metabolic product of GTS-21 (HBP:CONSO00310) in which the methoxy at the 4-position has been cleaved to leave a hydroxyl 4-OH-GTS-21 3-(4-hydroxy-2-methoxybenzylidene) anabaseine 3-(4-hydroxy-2-methoxybenzylidene)anabaseine 4OH-GTS-21 pubmed:25514383 inchi:InChI=1S/C18H18N2O2/c1-22-17-11-16(21)7-6-13(17)10-14-4-3-9-20-18(14)15-5-2-8-19-12-15/h2,5-8,10-12,21H,3-4,9H2,1H3/b14-10+ mesh:C116666 smiles:COC1=C(C=CC(=C1)O)C=C2CCCN=C2C3=CC=CN=C3 orcid:0000-0003-4423-4370 An animal model in which rats, immediately after weaning (usually postnatal day 21), are housed in isolation from siblings for an extended period (usually several weeks). In adulthood, these animals show many characteristics also seen in patients with schizophrenia isolation rearing pubmed:16820021 orcid:0000-0002-0303-8616 A chemical that inhibits the aggregation of the Tau protein (HGNC:MAPT) as form paired helical fragments (PHFs), straight filaments (SFs), oligomers, and larger aggregates Tau aggregation inhibitor pubmed:23484434 chebi:CHEBI:142738 orcid:0000-0003-4423-4370 A thiazole with two amino substituents 1,3-Thiazole-2,4-diamine 1,3-thiazole-2,4-diamine 2,4-thiazolediamine 67355-26-4 AB0070905 AB00987320-01 AC1L3O08 AC1Q4VRF AJ-67953 AK-30756 AKOS009092919 ANW-58036 BS-12711 F2145-0277 FT-0707053 KB-261000 M-8345 MCULE-4736308679 MFCD06738274 MolPort-002-471-220 QC-6319 SCHEMBL461605 ST24031901 TC-146781 Thiazole-2,4-diamine Z5019 ZINC15863137 diaminothiazole pubmed:21353545 pubmed:20524425 pubmed:11148059 inchi:InChI=1S/C3H5N3S/c4-2-1-7-3(5)6-2/h1H,4H2,(H2,5,6) pubchem.compound:118995 smiles:C1=C(N=C(S1)N)N orcid:0000-0003-4423-4370 Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is a genetic form of epilepsy that is caused by mutations in several genes, including genes encoding for the α4 and β2 subunits of the nicotinic acetylcholine (nACh) receptor Autosomal Dominant Nocturnal Frontal Lobe Epilepsy pubmed:30472464 doid:DOID:0060681 mesh:C579932 orcid:0000-0002-6117-4413 Anti-Ubiquitinylated proteins Antibod FK1 antibody pubmed:16338350 orcid:0000-0002-3034-9970 monoclonal antibody that is specific for amyloid-beta oligomers amyloid-beta antibody, NU1 pubmed:17403556 orcid:0000-0002-3034-9970 Here we report the discovery and characterization of 3-(3,4-difluorophenyl)-N-(1-(6-(4-(pyridin-2-yl)piperazin-1-yl)pyrazin-2-yl)ethyl)propanamide (B-973), a piperazine containing α7 type II PAM B-973 pubmed:28132910 inchi:InChI=1S/C24H26F2N6O/c1-17(29-24(33)8-6-18-5-7-19(25)20(26)14-18)21-15-27-16-23(30-21)32-12-10-31(11-13-32)22-4-2-3-9-28-22/h2-5,7,9,14-17H,6,8,10-13H2,1H3,(H,29,33)/t17-/m0/s1 smiles:C1=C(C(=CC=C1CCC(N[C@H](C2=CN=CC(=N2)N3CCN(CC3)C4=NC=CC=C4)C)=O)F)F orcid:0000-0002-6117-4413 An alignment of residues in the M3-M4 loop of alpha-7 nAChR that contribute to the binding of G-protein GPBC, alpha-7 nAChR pubmed:24185813 pubmed:26088141 orcid:0000-0002-3034-9970 An alignment of residues in the M3-M4 loop of GPBC, Glycine Receptor 1 (GLRA1) that contribute to the binding of G-protein GPBC, Glycine Receptor 1 pubmed:24185813 pubmed:26088141 orcid:0000-0002-3034-9970 N-terminal fragment of the protein ATF6, generated by cleavage through SP1 and SP2 proteases N-terminal fragment of ATF6 pubmed:25784053 orcid:0000-0002-7128-929X Proteins that are not able to achieve the native state, due either to an unwanted mutation in their amino acid sequence or simply because of an error in the folding process, are recognized as misfolded and subsequently targeted to a degradation pathway misfolded pubmed:16689923 orcid:0000-0002-6117-4413 A novel cholestane glycoside called OSW-1 (3b, 16b, 17a-trihydroxycholest-5-en-22-one 16-O-(2-O-4-methoxybenzoyl-bD-xylopyranosyl) - (1?3) -(2-O-acetyl-a-L-arabinopyranoside)) was recently isolated from Ornithogalum saundersiae (Kubo et al., 1992) and has been found to have a potent growth inhibitory activity on a human tumour cell line OSW-1 145075-81-6 CHEMBL375269 CS-0020992 HY-101213 OSW-1 SCHEMBL17383554 ZINC169358856 pubmed:9283720 chebml:CHEMBL375269 inchi:InChI=1S/C47H68O15/c1-24(2)8-15-34(50)25(3)47(55)37(21-33-31-14-11-28-20-29(49)16-18-45(28,5)32(31)17-19-46(33,47)6)60-44-41(59-26(4)48)39(36(52)23-58-44)62-43-40(38(53)35(51)22-57-43)61-42(54)27-9-12-30(56-7)13-10-27/h9-13,24-25,29,31-33,35-41,43-44,49,51-53,55H,8,14-23H2,1-7H3/t25-,29+,31-,32+,33+,35-,36+,37+,38+,39+,40-,41-,43+,44+,45+,46+,47-/m1/s1 mesh:C106408 pubchem.compound:9854230 smiles:COc1ccc(cc1)C(=O)O[C@@H]2[C@@H](O)[C@H](O)CO[C@H]2O[C@H]3[C@@H](O)CO[C@@H](O[C@H]4C[C@H]5[C@@H]6CC=C7C[C@@H](O)CC[C@]7(C)[C@H]6CC[C@]5(C)[C@@]4(O)[C@H](C)C(=O)CCC(C)C)[C@@H]3OC(=O)C orcid:0000-0002-6117-4413 low–molecular weight Hsp90 N-terminal domain inhibitor EC102 pubmed:17304350 orcid:0000-0002-7128-929X inhibitor of Aha1 KU-177 pubmed:28827321 orcid:0000-0002-7128-929X Ubb+1, a ubiquitin (Ub) mutant protein originating from misreading of the Ub B gene UBB+1 pubmed:29175520 orcid:0000-0002-7128-929X inhibitor of tau aggregation and toxicity in vitro and in cells Phenylthiazolyl-hydrazide pubmed:17685560 orcid:0000-0002-6117-4413 an acidic motif,EEVD, located at the extreme carboxyl terminus of nearly all Hsp7Os which has an essential role in regulating the biochemical properties of Hsp7O and interactions with HDJ-1 EEVD motif pubmed:7774586 orcid:0000-0002-6117-4413 Hsp27 exists as an ensemble of oligomers,which range in size from dimers to approximately 32 mers or greater Hsp27 oligomers pubmed:21882945 orcid:0000-0002-6117-4413 a dopamine D1 receptor partial agonist SK and F 77434 pubmed:16820021 orcid:0000-0002-0303-8616 a new selective iodinated salicylamide ligand for the labelling of dopamine D2 receptors with 125I. [125I]-NCQ 298 pubmed:16820021 orcid:0000-0002-0303-8616 Adeno-associated virus expressing Mouse Fkbp1b. AAV-FKBP1B pubmed:29255009 orcid:0000-0002-0303-8616 Regulation of the concentration, folding, interactions, and cellular localization of each of the proteins that comprise the proteome Proteostasis pubmed:29127110 mesh:D000074702 orcid:0000-0002-7128-929X Fragment of APP (N-APP) that contains heparin-binding and metal-binding domains and that has been found to have biological activity N-terminal fragment of APP pubmed:24916405 orcid:0000-0002-2046-6145 p(HGNC:APP, frag(1_?)) Aggregates due to mutations of proteins that lead to polyQ expansions polyQ aggregates pubmed:23483542 orcid:0000-0002-7128-929X Aggregates of proteins consisting of polyglutamine stretches with 82 glutamine residues Q82 aggregates pubmed:10811890 orcid:0000-0002-7128-929X Post-translational protein modifications that were not caused by enzymatic reactions non-enzymatic protein modification pubmed:24563850 orcid:0000-0002-7128-929X Tau aggregation inhibitor bb14 (from the rhodanine class of compounds) bb14 pubmed:26510979 orcid:0000-0002-7128-929X Tau aggregation inhibitor cmp16 pubmed:20392114 orcid:0000-0002-7128-929X Proteins that are not able to achieve the native state, due either to an unwanted mutation in their amino acid sequence or simply because of an error in the folding process, are recognized as misfolded and subsequently targeted to a degradation pathway misfolding pubmed:16689923 orcid:0000-0002-7128-929X ABAD inhibitor AG18051 pubmed:22174920 inchi:InChI=1S/C19H21N5OS/c25-18(23-10-6-1-2-7-11-23)16(14-8-4-3-5-9-14)24-13-20-17-15(19(24)26)12-21-22-17/h3-5,8-9,12-13,16H,1-2,6-7,10-11H2,(H,21,22) smiles:C1=N[N]C2=C1C(=S)N(C=N2)C(C(=O)C3CCCCCC3)C4=CC=CC=C4 orcid:0000-0002-7128-929X ABAD inhibitor RM-532-46 pubmed:22674910 inchi:InChI=1S/C30H44N2O3/c1-35-23-4-2-3-21(17-23)19-31-13-15-32(16-14-31)20-30(34)12-11-24-22(18-30)5-6-26-25(24)7-8-28-27(26)9-10-29(28)33/h2-4,17,22,24-28,34H,5-16,18-20H2,1H3/t22-,24-,25+,26+,27-,28-,30+/m0/s1 smiles:C1[C@H]4[C@H](C[C@](C1)(CN2CCN(CC2)CC3=CC(=CC=C3)OC)O)CC[C@@H]5[C@@H]4CC[C@H]6[C@H]5CCC6=O orcid:0000-0002-7128-929X The removal of an amide group from a peptide's side chain deamidation pubmed:26631930 orcid:0000-0003-4423-4370 A standardized and structured interview originally developed by Marshal Folstein, Susan Folstein and Paul McHugh (Journal of Psychiatric Research, 1975), which is used to evaluate an individual's cognitive function. Mini-Mental Status Exam Folstein Mini-Mental Status Exam MMS1 MMSE Mini-Mental State Examination Questionnaire Mini-Mental_Status_Exam ncit:C74982 umls:C0451306 orcid:0000-0003-4423-4370 glyceraldehyde-derived pyridinium-type advanced glycation end product (AGE), formed by glyceraldehyde-related glycation GLAP 1-(5-acetylamino-5-carboxypentyl)-3-hydroxy-5-hydroxymethyl-pyridinium Glyceraldehyde derived Pyridinium compound Glyceraldehyde-derived Pyridinium compound pubmed:25582325 pubmed:17284838 inchi:InChI=1S/C12H18N2O4/c13-4-2-1-3-11(12(17)18)14-6-9(8-15)5-10(16)7-14/h5-7,11,15H,1-4,8,13H2,(H-,16,17,18)/t11-/m0/s1 smiles:NCCCC[C@@H](C(=O)O)[N+]1=CC(=CC(=C1)[O-])CO orcid:0000-0002-7128-929X In addition to the 3′ splice site at the end of exon 6, there are two alternate 3′ splice sites within exon 6 itself, termed “6P” and “6D” according to location (Fig. 1). Use of either of these splice sites results in a frame shift that introduces a unique amino acid sequence, PCCVPRATFLS (6P) or FWSKGDETQGG (6D), followed by a stop codon. As a result, tau 6P and 6D isoforms are truncated, lacking part of the proline-rich region, the MTBR region, and C-terminus Tau 6D pubmed:21734277 pubmed:19919107 orcid:0000-0002-6117-4413 In addition to the 3′ splice site at the end of exon 6, there are two alternate 3′ splice sites within exon 6 itself, termed “6P” and “6D” according to location (Fig. 1). Use of either of these splice sites results in a frame shift that introduces a unique amino acid sequence, PCCVPRATFLS (6P) or FWSKGDETQGG (6D), followed by a stop codon. As a result, tau 6P and 6D isoforms are truncated, lacking part of the proline-rich region, the MTBR region, and C-terminus Tau 6P pubmed:21734277 pubmed:19919107 orcid:0000-0002-6117-4413 Parts of the body that act as a response to a change in the environment, the body's functions, molecule levels, etc. Peripheral Tissue pubmed:27758088 orcid:0000-0002-7128-929X Antibodies, that are able to bind different epitopes of the tau protein tau polyclonal antibody pubmed:29590627 orcid:0000-0002-7128-929X oligomers form during the early steps of TDP-43 misfolding TDP-43 oligomers pubmed:30824544 orcid:0000-0002-6117-4413 TDP-43 aggregates are formed through a biphasic process that initiates with oligomerization followed by aggregation into high molecular weight polymers TDP-43 aggregates pubmed:30824544 orcid:0000-0002-6117-4413 Multiplication or reproduction by cell division of a population of identical cells descended from a single progenitor. In immunology, may refer to the clonal proliferation of cells responsive to a specific antigen as part of an immune response. Clonal Expansion pubmed:27794524 ncit:C20613 orcid:0000-0002-7683-0452 Clinical Dementia Rating (CDR) Sum of Boxes CDR - Sum of Boxes pubmed:25468261 pubmed:23626081 pubmed:27084223 ncit:C113880 umls:C3827230 orcid:0000-0003-4423-4370 mouse monoclonal antibody specific to tau epitopes within 312 to 322 amino acid Tau antibody, MC1 pubmed:28148553 pubmed:21841002 pubmed:23638068 antibodyregistry:AB_2314773 orcid:0000-0002-7683-0452 recombinant mouse antibody specifc to MAPT DC8E8 pubmed:4255369 pubmed:25478017 pdb:4OZ4 url:https://www.creativebiolabs.net/Anti-Tau-Antibody-24886.htm orcid:0000-0002-7683-0452 monoclonal mouse antibody specifc to MAPT DC11 pubmed:4255369 pubmed:12544837 orcid:0000-0002-7683-0452 recombinant mouse antibody binding to PHF core of MAPT MN423 pubmed:4255369 pubmed:25478017 pdb:2V17 url:https://www.creativebiolabs.net/Anti-PHF-core-Antibody-24396.htm orcid:0000-0002-7683-0452 active vaccine eliciting an immune response against pathologically modified forms of tau protein AADvac1 pubmed:25478017 url:https://www.alzforum.org/therapeutics/aadvac1 orcid:0000-0002-7683-0452 HDAC3 inhibitor RGFP136 N-(6-(2-amino-4-fluorophenylamino)-6-oxohexyl)-4-methylbenzamide RGFP 136 pubmed:21228185 pubmed:23356410 inchi:InChI=1S/C20H24FN3O2/c1-14-6-8-15(9-7-14)20(26)23-12-4-2-3-5-19(25)24-18-11-10-16(21)13-17(18)22/h6-11,13H,2-5,12,22H2,1H3,(H,23,26)(H,24,25) mesh:C556032 smiles:NC1=C(C=CC(=C1)F)NC(CCCCCNC(C1=CC=C(C=C1)C)=O)=O orcid:0000-0002-7683-0452 Compounds that inhibit Histone Deactelylase 3(HDAC-3) HDAC3 inhibitor pubmed:21228185 pubmed:23356410 orcid:0000-0002-7683-0452 Long-term chemotherapy-induced cognitive decline in cancer survivors chemofog CICI Chemotherapy-induced cognitive impairment chemo brain chemobrain pubmed:30112764 pubmed:28916767 pubmed:30382534 orcid:0000-0003-4423-4370 neuropathy caused by chemotherapy Chemotherapy-induced peripheral neuropathy CIPN chemotherapy induced peripheral neuropathy pubmed:31363906 pubmed:25256375 pubmed:31783290 pubmed:24830939 pubmed:30244980 orcid:0000-0003-4423-4370 chemotherapy induced peripheral neuropathy pubmed:25256375 CIPN pubmed:25256375 chemobrain pubmed:20832978 chemo brain pubmed:20832978 Chemotherapy-induced cognitive impairment pubmed:20832978 CICI pubmed:20832978 RGFP 136 mesh:C556032 N-(6-(2-amino-4-fluorophenylamino)-6-oxohexyl)-4-methylbenzamide mesh:C556032 Glyceraldehyde-derived Pyridinium compound pubmed:12784645 Glyceraldehyde derived Pyridinium compound pubmed:12784645 1-(5-acetylamino-5-carboxypentyl)-3-hydroxy-5-hydroxymethyl-pyridinium pubmed:12784645 Mini-Mental_Status_Exam ncit:C74982 Mini-Mental State Examination Questionnaire ncit:C74982 MMSE ncit:C74982 MMS1 ncit:C74982 Folstein Mini-Mental Status Exam ncit:C74982 ZINC169358856 pubchem.compound:9854230 SCHEMBL17383554 pubchem.compound:9854230 OSW-1 pubchem.compound:9854230 HY-101213 pubchem.compound:9854230 CS-0020992 pubchem.compound:9854230 CHEMBL375269 pubchem.compound:9854230 145075-81-6 pubchem.compound:9854230 diaminothiazole pubchem.compound:118995 ZINC15863137 pubchem.compound:118995 Z5019 pubchem.compound:118995 Thiazole-2,4-diamine pubchem.compound:118995 TC-146781 pubchem.compound:118995 ST24031901 pubchem.compound:118995 SCHEMBL461605 pubchem.compound:118995 QC-6319 pubchem.compound:118995 MolPort-002-471-220 pubchem.compound:118995 MFCD06738274 pubchem.compound:118995 MCULE-4736308679 pubchem.compound:118995 M-8345 pubchem.compound:118995 KB-261000 pubchem.compound:118995 FT-0707053 pubchem.compound:118995 F2145-0277 pubchem.compound:118995 BS-12711 pubchem.compound:118995 ANW-58036 pubchem.compound:118995 AKOS009092919 pubchem.compound:118995 AK-30756 pubchem.compound:118995 AJ-67953 pubchem.compound:118995 AC1Q4VRF pubchem.compound:118995 AC1L3O08 pubchem.compound:118995 AB00987320-01 pubchem.compound:118995 AB0070905 pubchem.compound:118995 67355-26-4 pubchem.compound:118995 2,4-thiazolediamine pubchem.compound:118995 1,3-thiazole-2,4-diamine pubchem.compound:118995 4OH-GTS-21 mesh:C116666 3-(4-hydroxy-2-methoxybenzylidene)anabaseine pubmed:25514383 3-(4-hydroxy-2-methoxybenzylidene) anabaseine pubmed:25514383 ZINC860 pubchem.compound:5310985 X5075 pubchem.compound:5310985 X5074 pubchem.compound:5310985 UNII-8S399XDN2K pubchem.compound:5310985 STL441849 pubchem.compound:5310985 SCHEMBL316746 pubchem.compound:5310985 SCHEMBL316745 pubchem.compound:5310985 NSC_122225 pubchem.compound:5310985 MolPort-004-975-791 pubchem.compound:5310985 KB-77635 pubchem.compound:5310985 Gts-21 pubchem.compound:5310985 GTS-21 drugbank:DB05708 GTS 21 pubmed:25514383 Dimethoxybenzylidene anabaseine pubchem.compound:5310985 DMXB-A pubchem.compound:5310985 DB05708 pubchem.compound:5310985 CHEMBL134713 pubchem.compound:5310985 CAS_156223-05-1 pubchem.compound:5310985 C19905 pubchem.compound:5310985 BDBM86543 pubchem.compound:5310985 BDBM50061564 pubchem.compound:5310985 BBL035625 pubchem.compound:5310985 ASIS-0106 pubchem.compound:5310985 AKOS005146470 pubchem.compound:5310985 AC1NSJRW pubchem.compound:5310985 A15950 pubchem.compound:5310985 8S399XDN2K pubchem.compound:5310985 419A471 pubchem.compound:5310985 3-[1-(2,4-Dimethoxy-phenyl)-meth-(E)-ylidene]-3,4,5,6-tetrahydro-[2,3'']bipyridinyl pubchem.compound:5310985 3-[(E)-(2,4-Dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-2,3'-bipyridine pubchem.compound:5310985 3-[(5E)-5-[(2,4-dimethoxyphenyl)methylidene]-3,4-dihydro-2H-pyridin-6-yl]pyridine pubchem.compound:5310985 3-[(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-3,4,5,6-tetrahydropyridin-2-yl]pyridine drugbank:DB05708 3-[(3E)-3-[(2,4-DIMETHOXYPHENYL)METHYLIDENE]-5,6-DIHYDRO-4H-PYRIDIN-2-YL]PYRIDINE pubchem.compound:5310985 3-[(2,4-dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-2,3'-Bipyridine pubchem.compound:5310985 3-[(2,4-dimethoxy)benzylidene]-anabaseine pubchem.compound:5310985 3-(4-hydroxy-2-methoxybenzylidene)anabaseine pubmed:25514383 3-(3-(2,4-dimethoxybenzylidene)-3,4,5,6-tetrahydropyridin-2-yl)pyridine pubchem.compound:5310985 3-(2,4-dimethoxybenzylidene)anabaseine pubchem.compound:5310985 3-(2,4-Dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine pubchem.compound:5310985 3-(2,4-Dimethoxy-benzylidene)-3,4,5,6-tetrahydro-[2,3']bipyridinyl pubchem.compound:5310985 3,4,5,6-Tetrahydro-3-(2,4-dimethoxybenzylidene)-2,3'-bipyridine pubchem.compound:5310985 3 (2,4 dimethoxybenzylidene)anabaseine pubchem.compound:5310985 2wnj pubchem.compound:5310985 2,4-Dimethoxybenzylidene anabaseine pubchem.compound:5310985 2,3'-Bipyridine, 3-[(2,4-dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-, hydrochloride (1:2), (3E)- pubchem.compound:5310985 2,3'-Bipyridine, 3-((2,4-dimethoxyphenyl)methylene)-3,4,5,6-tetrahydro-, (3E)- pubchem.compound:5310985 148372-04-7 pubchem.compound:5310985 (3e)-3-[(2,4-Dimethoxyphenyl)methylidene]-3,4,5,6-Tetrahydro-2,3'-Bipyridine pubchem.compound:5310985 (3E)-3-[(2,4-DIMETHOXYPHENYL)METHYLIDENE]-3,4,5,6-TETRAHYDRO-2,3''-BIPYRIDINE pubchem.compound:5310985 (3E)-3-(2,4-dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine pubchem.compound:5310985 SCHEMBL5948853 pubchem.compound:9888248 S 24795, >=98% (HPLC) pubchem.compound:9888248 S 24795 pubchem.compound:9888248 MolPort-023-276-831 pubchem.compound:9888248 LERUHBBUGAOYOD-UHFFFAOYSA-M pubchem.compound:9888248 KB-80442 pubchem.compound:9888248 API0014115 pubchem.compound:9888248 AKOS024457657 pubchem.compound:9888248 304679-75-2 pubchem.compound:9888248 2-[2-(4-bromophenyl)-2-oxoethyl]-1-methylpyridiniumiodide pubchem.compound:9888248 2-[2-(4-Bromophenyl)-2-oxoethyl]-1-methylpyridinium iodide pubchem.compound:9888248 s2823 pubchem.compound:11313622 ZINC13985228 pubchem.compound:11313622 X5395 pubchem.compound:11313622 W-5777 pubchem.compound:11313622 UNII-Q747Y6TT42 pubchem.compound:11313622 Tideglusib,CAS:865854-05-3 pubchem.compound:11313622 Tideglusib, >=98% (HPLC) pubchem.compound:11313622 Tideglusib(NP-031112) pubchem.compound:11313622 Tideglusib [INN] pubchem.compound:11313622 Tideglusib (NP031112, NP-12) pubchem.compound:11313622 Tideglusib pubchem.compound:11313622 SCHEMBL676929 pubchem.compound:11313622 SB19268 pubchem.compound:11313622 RL05359 pubchem.compound:11313622 Q747Y6TT42 pubchem.compound:11313622 NP031112 pubchem.compound:11313622 NP-12 pubchem.compound:11313622 NP-031112|||4-Benzyl-2-naphthalen-1-yl-1,2,4-thiadiazolidine-3,5-dione pubchem.compound:11313622 NP-031112 pubchem.compound:11313622 NP 031112 pubchem.compound:11313622 MolPort-028-599-952 pubchem.compound:11313622 MFCD18633296 pubchem.compound:11313622 KB-81154 pubchem.compound:11313622 J-514478 pubchem.compound:11313622 HY-14872 pubchem.compound:11313622 GTPL6929 pubchem.compound:11313622 FT-0700382 pubchem.compound:11313622 EX-A600 pubchem.compound:11313622 DTXSID90235682 pubchem.compound:11313622 DB12129 pubchem.compound:11313622 DA-41071 pubchem.compound:11313622 D0UT7X pubchem.compound:11313622 CS-0613 pubchem.compound:11313622 CHEMBL3545157 pubchem.compound:11313622 C19H14N2O2S pubchem.compound:11313622 BDBM50166940 pubchem.compound:11313622 BCP06016 pubchem.compound:11313622 BC600768 pubchem.compound:11313622 AOB5562 pubchem.compound:11313622 AKOS025149085 pubchem.compound:11313622 AK176015 pubchem.compound:11313622 865854-05-3 pubchem.compound:11313622 4CA-1249 pubchem.compound:11313622 4-benzyl-2-naphthalen-1-yl-1,2,4-thiadiazolidine-3,5-dione pubchem.compound:11313622 4-benzyl-2-(naphthalen-1-yl)-(1,2,4)thiadiazolidine-3,5-dione pubchem.compound:11313622 4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione pubchem.compound:11313622 4-Benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione pubchem.compound:11313622 1,2,4-Thiadiazolidine-3,5-dione, 2-(1-naphthalenyl)-4-(phenylmethyl)- pubchem.compound:11313622 ZINC5699183 pubchem.compound:54682951 X033PDI962 pubchem.compound:54682951 UNII-X033PDI962 pubchem.compound:54682951 Sudoxicamum [INN-Latin] pubchem.compound:54682951 Sudoxicamum pubchem.compound:54682951 Sudoxicam [USAN:INN:BAN] pubchem.compound:54682951 Sudoxicam [USAN:BAN:INN] pubchem.compound:54682951 Sudoxicam (USAN/INN) pubchem.compound:54682951 SYCHUQUJURZQMO-UHFFFAOYSA-N pubchem.compound:54682951 SUDOXICAM pubchem.compound:54682951 SMR004701482 pubchem.compound:54682951 SCHEMBL35068 pubchem.compound:54682951 SCHEMBL35067 pubchem.compound:54682951 Oprea1_704902 pubchem.compound:54682951 NSC615046 pubchem.compound:54682951 NSC-615046 pubchem.compound:54682951 NSC 615046 pubchem.compound:54682951 N-(2-Thiazolyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-Dioxide pubchem.compound:54682951 MLS006010801 pubchem.compound:54682951 LS-40541 pubchem.compound:54682951 J-019435 pubchem.compound:54682951 FT-0674694 pubchem.compound:54682951 EINECS 251-808-7 pubchem.compound:54682951 DTXSID50187653 pubchem.compound:54682951 D05937 pubchem.compound:54682951 CTK8G3246 pubchem.compound:54682951 CP-15973 pubchem.compound:54682951 CP-15,973 pubchem.compound:54682951 CP 15973 pubchem.compound:54682951 CHEMBL20634 pubchem.compound:54682951 BRN 0628704 pubchem.compound:54682951 AKOS030239604 pubchem.compound:54682951 ACM34042858 pubchem.compound:54682951 AC1NSM46 pubchem.compound:54682951 AC1NSEW2 pubchem.compound:54682951 AC1L1W79 pubchem.compound:54682951 4-hydroxy-2-methyl-N-(2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide pubchem.compound:54682951 4-hydroxy-2-methyl-1,1-dioxo-N-thiazol-2-yl-1$l^{6},2-benzothiazine-3-carboxamide pubchem.compound:54682951 4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide pubchem.compound:54682951 4-Hydroxy-2-methyl-N-1,3-thiazol-2-yl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide pubchem.compound:54682951 4-Hydroxy-2-methyl-N-(1,3-thiazol-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide pubchem.compound:54682951 34042-85-8 pubchem.compound:54682951 3-[hydroxy-(1,3-thiazol-2-ylamino)methylidene]-2-methyl-1,1-dioxo-1 pubchem.compound:54682951 2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-thiazolyl-, 1,1-dioxide pubchem.compound:54682951 (3Z)-3-[hydroxy-(1,3-thiazol-2-ylamino)methylidene]-2-methyl-1,1-dioxo-1 pubchem.compound:54682951 (3E)-3-[hydroxy-(1,3-thiazol-2-ylamino)methylidene]-2-methyl-1,1-dioxo-1 pubchem.compound:54682951 hydroxyoxazolinone pubchem.compound:97389 ZINC1709820 pubchem.compound:97389 Z56762271 pubchem.compound:97389 UNII-R22D15229R pubchem.compound:97389 TC-146724 pubchem.compound:97389 SCHEMBL8159833 pubchem.compound:97389 SCHEMBL1395587 pubchem.compound:97389 SCHEMBL123971 pubchem.compound:97389 SC-49693 pubchem.compound:97389 R22D15229R pubchem.compound:97389 Oxazolidinedione pubchem.compound:97389 OXAZOLIDINE-2,4-DIONE pubchem.compound:97389 NSC120350 pubchem.compound:97389 NSC-120350 pubchem.compound:97389 NSC 120350 pubchem.compound:97389 MolPort-018-280-326 pubchem.compound:97389 MFCD02691902 pubchem.compound:97389 KS-00000MOC pubchem.compound:97389 KB-67472 pubchem.compound:97389 FT-0704394 pubchem.compound:97389 F2167-1227 pubchem.compound:97389 DS-15871 pubchem.compound:97389 DA-18172 pubchem.compound:97389 CTK0H9315 pubchem.compound:97389 COWNFYYYZFRNOY-UHFFFAOYSA-N pubchem.compound:97389 CMLDBU00003511 pubchem.compound:97389 CJ-28984 pubchem.compound:97389 ANW-57979 pubchem.compound:97389 AN-50728 pubchem.compound:97389 AKOS002529400 pubchem.compound:97389 AK-80133 pubchem.compound:97389 AJ-30743 pubchem.compound:97389 AC1L3YF0 pubchem.compound:97389 A816734 pubchem.compound:97389 346O261 pubchem.compound:97389 2346-26-1 pubchem.compound:97389 2,4oxazolidinedione pubchem.compound:97389 2,4-Oxazolidinedione pubchem.compound:97389 2,4-Oxazolidenedione pubchem.compound:97389 1572AB pubchem.compound:97389 153301-EP2281822A1 pubchem.compound:97389 12770-97-7 pubchem.compound:97389 1,3-oxazolidine-2,4-dione pubchem.compound:97389 1,3-oxazolidin-2,4-dione pubchem.compound:97389 purine deriv. 5 pubchem.compound:4592 olomoucine pubchem.compound:4592 ZX-AFC001655 pubchem.compound:4592 ZINC1641925 pubchem.compound:4592 UPCMLD-DP136:002 pubchem.compound:4592 UPCMLD-DP136:001 pubchem.compound:4592 UPCMLD-DP136 pubchem.compound:4592 UNII-6A839B2HYS pubchem.compound:4592 Tox21_500883 pubchem.compound:4592 Tocris-1284 pubchem.compound:4592 TRA0035611 pubchem.compound:4592 ST50298830 pubchem.compound:4592 SR-01000075518-6 pubchem.compound:4592 SR-01000075518-3 pubchem.compound:4592 SR-01000075518-1 pubchem.compound:4592 SR-01000075518 pubchem.compound:4592 SMP1_000281 pubchem.compound:4592 SCHEMBL135056 pubchem.compound:4592 RT-014854 pubchem.compound:4592 Olomucine pubchem.compound:4592 Olomoucine, >=98% (HPLC) pubchem.compound:4592 OLO pubchem.compound:4592 O 0886 pubchem.compound:4592 NSC666096 pubchem.compound:4592 NSC-666096 pubchem.compound:4592 NSC 666096 pubchem.compound:4592 NCI60_022916 pubchem.compound:4592 NCGC00261568-01 pubchem.compound:4592 NCGC00025096-07 pubchem.compound:4592 NCGC00025096-06 pubchem.compound:4592 NCGC00025096-05 pubchem.compound:4592 NCGC00025096-04 pubchem.compound:4592 NCGC00025096-03 pubchem.compound:4592 NCGC00025096-02 pubchem.compound:4592 NCGC00025096-01 pubchem.compound:4592 NCGC00015763-09 pubchem.compound:4592 NCGC00015763-08 pubchem.compound:4592 NCGC00015763-07 pubchem.compound:4592 NCGC00015763-06 pubchem.compound:4592 NCGC00015763-05 pubchem.compound:4592 NCGC00015763-04 pubchem.compound:4592 NCGC00015763-03 pubchem.compound:4592 NCGC00015763-02 pubchem.compound:4592 NCGC00015763-01 pubchem.compound:4592 MolPort-003-849-700 pubchem.compound:4592 MFCD00189360 pubchem.compound:4592 Lopac0_000883 pubchem.compound:4592 Lopac-O-0886 pubchem.compound:4592 LP00883 pubchem.compound:4592 Kinome_2870 pubchem.compound:4592 KBioSS_000330 pubchem.compound:4592 KBioGR_000330 pubchem.compound:4592 KBio3_000660 pubchem.compound:4592 KBio3_000659 pubchem.compound:4592 KBio2_005466 pubchem.compound:4592 KBio2_002898 pubchem.compound:4592 KBio2_000330 pubchem.compound:4592 KB-162429 pubchem.compound:4592 J-000453 pubchem.compound:4592 InSolution™ Olomoucine pubchem.compound:4592 IN1182 pubchem.compound:4592 IN1179 pubchem.compound:4592 IDI1_002090 pubchem.compound:4592 HMS3676E10 pubchem.compound:4592 HMS3650F19 pubchem.compound:4592 HMS3403B11 pubchem.compound:4592 HMS3267L09 pubchem.compound:4592 HMS3262B08 pubchem.compound:4592 HMS1990B11 pubchem.compound:4592 HMS1792B11 pubchem.compound:4592 HMS1362B11 pubchem.compound:4592 GTVPOLSIJWJJNY-UHFFFAOYSA-N pubchem.compound:4592 FT-0642456 pubchem.compound:4592 Ethanol,2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]- pubchem.compound:4592 Ethanol, 2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]- pubchem.compound:4592 EU-0100883 pubchem.compound:4592 DTXSID90144068 pubchem.compound:4592 DB02116 pubchem.compound:4592 D00BPA pubchem.compound:4592 CTK4A0020 pubchem.compound:4592 CJ-26517 pubchem.compound:4592 CHEMBL280074 pubchem.compound:4592 CCG-100650 pubchem.compound:4592 CBiol_002050 pubchem.compound:4592 C15H18N6O pubchem.compound:4592 C-28477 pubchem.compound:4592 BiomolKI_000046 pubchem.compound:4592 BiomolKI2_000052 pubchem.compound:4592 Bio2_000815 pubchem.compound:4592 Bio2_000335 pubchem.compound:4592 Bio1_001314 pubchem.compound:4592 Bio1_000825 pubchem.compound:4592 Bio1_000336 pubchem.compound:4592 BSPBio_000990 pubchem.compound:4592 BRD-K82731415-001-04-7 pubchem.compound:4592 BRD-K82731415-001-03-9 pubchem.compound:4592 BMK1-E10 pubchem.compound:4592 BIO3107 pubchem.compound:4592 BDBM5718 pubchem.compound:4592 BCBcMAP01_000205 pubchem.compound:4592 AKOS005145988 pubchem.compound:4592 ACMC-20cp0o pubchem.compound:4592 AC1Q4XZU pubchem.compound:4592 AC1L1IID pubchem.compound:4592 6A839B2HYS pubchem.compound:4592 6-benzylamino-2-[2-hydroxyethylamino]-9-methylpurine pubchem.compound:4592 6-Benzylamino-2-(2-hydroxyethylamino)-9-methylpurine pubchem.compound:4592 6-Benylamino-2-(2-hydroxyethylamino)-9-methylpurine pubchem.compound:4592 6-(benzylamino)-2-[(2-hydroxyethyl)amino]-9-methylpurine pubchem.compound:4592 6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine pubchem.compound:4592 4erk pubchem.compound:4592 2-{[6-(benzylamino)-9-methyl-9h-purin-2-yl]amino}ethanol pubchem.compound:4592 2-{[6-(benzylamino)-9-methyl-9H-purin-2-yl]amino}ethan-1-ol pubchem.compound:4592 2-[[9-methyl-6-(phenylmethylamino)purin-2-yl]amino]ethanol pubchem.compound:4592 2-[[9-Methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]ethanol, 9CI pubchem.compound:4592 2-[[9-Methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]ethanol pubchem.compound:4592 2-[[9-Methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-ethanol pubchem.compound:4592 2-[[6-(benzylamino)-9-methylpurin-2-yl]amino]ethanol pubchem.compound:4592 2-[[6-(benzylamino)-9-methyl-purin-2-yl]amino]ethanol pubchem.compound:4592 2-({9-methyl-6-[benzylamino]purin-2-yl}amino)ethan-1-ol pubchem.compound:4592 2-(Hydroxyethylamino)-6-benzylamino-9-methylpurine pubchem.compound:4592 2-(6-(benzylamino)-9-methyl-9H-purin-2-ylamino)ethanol pubchem.compound:4592 2-(2-Hydroxyethylamino)-6-benzylamino-9-methylpurine pubchem.compound:4592 2-(2-Hydroxyethylamino)-6-benzylamino-9-isopropylpurine pubchem.compound:4592 2-(2-Hydroxyethylamino)-6-(benzylamino)-9-methylpurine pubchem.compound:4592 2,6,9-Trisubstituted purine deriv. 26 pubchem.compound:4592 1w0x pubchem.compound:4592 1966AH pubchem.compound:4592 101622-51-9 pubchem.compound:4592 UNII-9P59GES78D pubchem.compound:71460273 Maitotoxin 1 pubchem.compound:71460273 Maitotoxin pubchem.compound:71460273 HSDB 7753 pubchem.compound:71460273 CHEMBL2152261 pubchem.compound:71460273 9P59GES78D pubchem.compound:71460273 n-isopentenyladenine pubchem.compound:92180 isopentenyl-adenine pubchem.compound:92180 ZX-AFC000343 pubchem.compound:92180 ZINC32351 pubchem.compound:92180 ZB000921 pubchem.compound:92180 V500BB256Z pubchem.compound:92180 V0538 pubchem.compound:92180 UNII-V500BB256Z pubchem.compound:92180 TimTec1_003281 pubchem.compound:92180 ST24048354 pubchem.compound:92180 ST044513 pubchem.compound:92180 SCHEMBL459276 pubchem.compound:92180 SC-18768 pubchem.compound:92180 Oprea1_344117 pubchem.compound:92180 NSC106958 pubchem.compound:92180 NSC-106958 pubchem.compound:92180 NSC 106958 pubchem.compound:92180 NCIStruc2_000921 pubchem.compound:92180 NCIStruc1_000935 pubchem.compound:92180 NCI60_000165 pubchem.compound:92180 NCI106958 pubchem.compound:92180 NCGC00097193-01 pubchem.compound:92180 NCGC00014084-02 pubchem.compound:92180 NCGC00014084 pubchem.compound:92180 N6-Isopentenyladenine pubchem.compound:92180 N6-Dimethylallyladenine pubchem.compound:92180 N6-Delta2-isopentenyladenine pubchem.compound:92180 N6-.DELTA.2-Isopentenyl)adenine pubchem.compound:92180 N6-(delta2-Isopentenyl)aminopurine pubchem.compound:92180 N6-(delta2-Isopentenyl)adenine pubchem.compound:92180 N6-(delta2-Isopentenyl)-adenine pubchem.compound:92180 N6-(delta 2-Isopentenyl)-adenine pubchem.compound:92180 N6-(3-Methylbut-2-enyl)adenine pubchem.compound:92180 N6-(3-Methyl-2-butenyl)adenine pubchem.compound:92180 N6-(2-Isopentenyl)adenine pubchem.compound:92180 N6-(2-Isopentenyl)-adenine pubchem.compound:92180 N6-(.DELTA.2-Isopentenyl)aminopurine pubchem.compound:92180 N6-(.DELTA.2-Isopentenyl)adenine pubchem.compound:92180 N6 -(Delta2 -Isopentenyl)adenine pubchem.compound:92180 N-6-(delta2-Isopentenyl)-adenine pubchem.compound:92180 N-6-(3,3-Dimethylallyl)adenine pubchem.compound:92180 N-(gamma,gamma-Dimethylallyl)adenine pubchem.compound:92180 N-(delta2-Isopentenyl)adenine pubchem.compound:92180 N-(3-methylbut-2-enyl)-9H-purin-6-amine pubchem.compound:92180 N-(3-methylbut-2-enyl)-7H-purin-6-amine pubchem.compound:92180 N-(3-methylbut-2-en-1-yl)-7H-purin-6-amine pubchem.compound:92180 N-(3-methyl-2-butenyl)-9H-purin-6-amine pubchem.compound:92180 N-(3-Methyl-2-butenyl)adenine pubchem.compound:92180 N-(3-Methyl-2-butenyl)-1H-purin-6-amine # pubchem.compound:92180 N-(3-Methyl-2-butenyl)-1H-purin-6-amine pubchem.compound:92180 N-(3-METHYLBUT-2-EN-1-YL)-9H-PURIN-6-AMINE pubchem.compound:92180 N-(.gamma.,.gamma.-Dimethylallyl)adenine pubchem.compound:92180 N-(.DELTA.2-Isopentenyl)adenine pubchem.compound:92180 N(6)-dimethylallyladenine pubchem.compound:92180 N(6)-(delta(2)-Isopentenyl)adenine pubchem.compound:92180 N(6)-(Delta2-isopentenyl)adenine pubchem.compound:92180 N(6)-(.DELTA.2-Isopentenyl)aminopurine pubchem.compound:92180 MolPort-002-511-573 pubchem.compound:92180 MFCD00132998 pubchem.compound:92180 MCULE-6781114249 pubchem.compound:92180 LS-184209 pubchem.compound:92180 KB-57456 pubchem.compound:92180 Isopentenyladenine pubchem.compound:92180 Isopentenyl adenine pubchem.compound:92180 IPADE pubchem.compound:92180 I14-7114 pubchem.compound:92180 HYVABZIGRDEKCD-UHFFFAOYSA-N pubchem.compound:92180 HY-112103 pubchem.compound:92180 HMS1543F03 pubchem.compound:92180 FT-0629731 pubchem.compound:92180 Enadenine pubchem.compound:92180 EBD28940 pubchem.compound:92180 Dimethylallyladenine pubchem.compound:92180 DTXSID10178325 pubchem.compound:92180 DB08768 pubchem.compound:92180 D0I1SZ pubchem.compound:92180 D-4760 pubchem.compound:92180 CTK8G1492 pubchem.compound:92180 CS-0043352 pubchem.compound:92180 CI-027 pubchem.compound:92180 CHEMBL476189 pubchem.compound:92180 CHEBI:17660 pubchem.compound:92180 CCG-38046 pubchem.compound:92180 C04083 pubchem.compound:92180 BRD-K62158429-001-01-7 pubchem.compound:92180 BID525 pubchem.compound:92180 BC209320 pubchem.compound:92180 Adenine, N-(3-methyl-2-butenyl)- (8CI) pubchem.compound:92180 Adenine, N-(3-methyl-2-butenyl)- pubchem.compound:92180 AX8017021 pubchem.compound:92180 AS-17517 pubchem.compound:92180 AN-50750 pubchem.compound:92180 AKOS028109417 pubchem.compound:92180 AKOS015914857 pubchem.compound:92180 AKOS005257639 pubchem.compound:92180 AK163607 pubchem.compound:92180 ACM2365404 pubchem.compound:92180 AC1L3NL1 pubchem.compound:92180 AC-15608 pubchem.compound:92180 A816825 pubchem.compound:92180 6-[(3-methylbut-2-en-1-yl)amino]purine pubchem.compound:92180 6-[(3-Methyl-2-butenyl)amino]purine pubchem.compound:92180 6-(|A,|A-Dimethylallylamino)purine pubchem.compound:92180 6-(gamma,gamma-Dimethylallylamino)purine, Vetec(TM) reagent grade, >=98.5% pubchem.compound:92180 6-(gamma,gamma-Dimethylallylamino)purine, BioReagent, plant cell culture tested, >=98.5% pubchem.compound:92180 6-(gamma,gamma-Dimethylallylamino)purine, BioReagent, plant cell culture tested, >=90% pubchem.compound:92180 6-(gamma,gamma-Dimethylallylamino)purine, BioReagent, plant cell culture tested, 1 mg/mL pubchem.compound:92180 6-(gamma,gamma-Dimethylallylamino)purine pubchem.compound:92180 6-(gamma,gamma-DIMETHYLALLYLAMINO) PURINE pubchem.compound:92180 6-(3-methyl-2-buten-1-ylamino)purine pubchem.compound:92180 6-(3,3-DIMETHYLALLYLAMINO)PURINE pubchem.compound:92180 6-(.gamma.,.gamma.-Dimethylallylamino)purine pubchem.compound:92180 6-((3-Methyl-2-butenyl)amino)purine pubchem.compound:92180 5122-37-2 pubchem.compound:92180 365I404 pubchem.compound:92180 3-methylbut-2-enyl(7H-purin-6-yl)amine pubchem.compound:92180 2exm pubchem.compound:92180 2365-40-4 pubchem.compound:92180 1H-Purin-6-amine, N-(3-methyl-2-butenyl)- (9CI) pubchem.compound:92180 1H-Purin-6-amine, N-(3-methyl-2-butenyl)- pubchem.compound:92180 13255-47-5 pubchem.compound:92180 (3-methylbut-2-enyl)purin-6-ylamine pubchem.compound:92180 (3-methyl-but-2-enyl)-(7(9)H-purin-6-yl)-amine pubchem.compound:92180 isocarboxazid pubchem.compound:3759 ZINC1587 pubchem.compound:3759 Y0484 pubchem.compound:3759 XKFPYPQQHFEXRZ-UHFFFAOYSA-N pubchem.compound:3759 WLN: T5NOJ C1 EVMM1R pubchem.compound:3759 UNII-34237V843T pubchem.compound:3759 Tox21_110336 pubchem.compound:3759 TC-146958 pubchem.compound:3759 SR-01000841192-3 pubchem.compound:3759 SR-01000841192-2 pubchem.compound:3759 SR-01000841192 pubchem.compound:3759 SPBio_002869 pubchem.compound:3759 SMR001233334 pubchem.compound:3759 SCHEMBL49562 pubchem.compound:3759 Ro5-0831 pubchem.compound:3759 Ro 5-0831/1 pubchem.compound:3759 Ro 5-0831 pubchem.compound:3759 Prestwick3_000795 pubchem.compound:3759 Prestwick2_000795 pubchem.compound:3759 Prestwick1_000795 pubchem.compound:3759 Prestwick0_000795 pubchem.compound:3759 NSC169893 pubchem.compound:3759 NSC-169893 pubchem.compound:3759 NSC 169893 pubchem.compound:3759 NCGC00016267-03 pubchem.compound:3759 NCGC00016267-02 pubchem.compound:3759 NCGC00016267-01 pubchem.compound:3759 N'-benzyl-5-methyl-1,2-oxazole-3-carbohydrazide pubchem.compound:3759 N'-Benzyl-5-methylisoxazole-3-carbohydrazide pubchem.compound:3759 N'-Benzyl-5-methyl-3-isoxazolecarbohydrazide # pubchem.compound:3759 N'-Benzyl N-methyl-5-isoxazolecarboxylhydrazide-3 pubchem.compound:3759 Marplon pubchem.compound:3759 Marplan (TN) pubchem.compound:3759 Marplan pubchem.compound:3759 Maraplan pubchem.compound:3759 MLS003106729 pubchem.compound:3759 MLS002154005 pubchem.compound:3759 LS-86607 pubchem.compound:3759 KB-258619 pubchem.compound:3759 Isocarboxyzid pubchem.compound:3759 Isocarboxizid pubchem.compound:3759 Isocarboxazidum [INN-Latin] pubchem.compound:3759 Isocarboxazidum pubchem.compound:3759 Isocarboxazide [INN-French] pubchem.compound:3759 Isocarboxazide pubchem.compound:3759 Isocarboxazida [INN-Spanish] pubchem.compound:3759 Isocarboxazida pubchem.compound:3759 Isocarboxazid [USP:INN:BAN] pubchem.compound:3759 Isocarboxazid [INN:BAN] pubchem.compound:3759 Isocarboxazid 5-methyl-3-isoxazole-carboxylic acid 2-benzylhydrazide, AldrichCPR pubchem.compound:3759 Isocarboxazid (INN) pubchem.compound:3759 Isocarboxazid (ICD) pubchem.compound:3759 Isocarbossazide [DCIT] pubchem.compound:3759 Isocarbossazide pubchem.compound:3759 Isocarbonazid pubchem.compound:3759 ISOCARBOXAZID (200 MG) pubchem.compound:3759 HY-13929 pubchem.compound:3759 HMS3714O12 pubchem.compound:3759 HMS3369G18 pubchem.compound:3759 HMS2230E11 pubchem.compound:3759 HMS2097O12 pubchem.compound:3759 HMS1570O12 pubchem.compound:3759 GTPL7204 pubchem.compound:3759 FT-0670438 pubchem.compound:3759 FCH2716017 pubchem.compound:3759 Enerzer pubchem.compound:3759 EINECS 200-438-4 pubchem.compound:3759 DTXSID4023171 pubchem.compound:3759 DSSTox_RID_76902 pubchem.compound:3759 DSSTox_GSID_23171 pubchem.compound:3759 DSSTox_CID_3171 pubchem.compound:3759 DB01247 pubchem.compound:3759 D0I2VK pubchem.compound:3759 D02580 pubchem.compound:3759 CTK8B7692 pubchem.compound:3759 CS-0008613 pubchem.compound:3759 CHEMBL1201168 pubchem.compound:3759 CHEBI:93635 pubchem.compound:3759 CCRIS 9178 pubchem.compound:3759 CCG-220795 pubchem.compound:3759 CAS-59-63-2 pubchem.compound:3759 Benazide pubchem.compound:3759 BSPBio_000930 pubchem.compound:3759 BRN 0201295 pubchem.compound:3759 BRD-K93332168-001-03-2 pubchem.compound:3759 BPBio1_001024 pubchem.compound:3759 BMIH pubchem.compound:3759 BDBM163692 pubchem.compound:3759 BC645218 pubchem.compound:3759 AX8135097 pubchem.compound:3759 API0000611 pubchem.compound:3759 ANW-58213 pubchem.compound:3759 AKOS016003091 pubchem.compound:3759 AJ-08053 pubchem.compound:3759 AC1L1GNE pubchem.compound:3759 AC-24841 pubchem.compound:3759 AB00513923 pubchem.compound:3759 59-63-2 pubchem.compound:3759 5-methyl-N'-(phenylmethyl)isoxazole-3-carbohydrazide pubchem.compound:3759 5-methyl-N'-(phenylmethyl)-3-isoxazolecarbohydrazide pubchem.compound:3759 5-Methyl-3-isoxazolecarboxylic acid 2-benzylhydrazide pubchem.compound:3759 4-27-00-03999 (Beilstein Handbook Reference) pubchem.compound:3759 34237V843T pubchem.compound:3759 3-Isoxazolecarboxylic acid, 5-methyl-, 2-benzylhydrazide pubchem.compound:3759 3-Isoxazolecarboxylic acid, 5-methyl-, 2-(phenylmethyl)hydrazide pubchem.compound:3759 3-Isoxazolecarboxylic acid, 2-benzylhydrazide pubchem.compound:3759 3-Isoxazolecarboxylic acid, 2-(phenylmethyl)hydrazide pubchem.compound:3759 3-(2-BENZYLHYDRAZOCARBOXY)-5-METHYL-ISOXAZOLE pubchem.compound:3759 1-Benzyl-2-(5-methyl-3-isoxazolylcarbonyl)hydrazine pubchem.compound:3759 1-Benzyl-2-(5-methyl-3-isoxazolyl-carbonyl)hydrazine pubchem.compound:3759 s7213 pubchem.compound:24808478 ZINC16052637 pubchem.compound:24808478 W-200641 pubchem.compound:24808478 Thiamet-G pubchem.compound:24808478 Thiamet G;\n2-(ethylamino)-3aR,6S,7R,7aR-tetrahydro-5R-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol pubchem.compound:24808478 Thiamet G, >=98% (HPLC) pubchem.compound:24808478 Thiamet G pubchem.compound:24808478 SW219118-1 pubchem.compound:24808478 SR-01000946377-1 pubchem.compound:24808478 SR-01000946377 pubchem.compound:24808478 NCGC00344096-03 pubchem.compound:24808478 MFCD15144964 pubchem.compound:24808478 J-000295 pubchem.compound:24808478 HY-12588 pubchem.compound:24808478 HMS3648I18 pubchem.compound:24808478 EX-A2240 pubchem.compound:24808478 C9H16N2O4S pubchem.compound:24808478 AOB5913 pubchem.compound:24808478 AKOS024458135 pubchem.compound:24808478 ACN-038039 pubchem.compound:24808478 5H-Pyrano[3,2-d]thiazole-6,7-diol, 2-(ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-, (3aR,5R,6S,7R,7aR)- pubchem.compound:24808478 2754AH pubchem.compound:24808478 2070AH pubchem.compound:24808478 1009816-48-1 pubchem.compound:24808478 1,2-Dideoxy-2'-ethylamino-a-D-glucopyranoso-[2,1-d]-2'-thiazoline pubchem.compound:24808478 (3aR,5R,6S,7R,7aR)-2-(ethylamino)-5-(hydroxymethyl)-3aH,5H,6H,7H,7aH-pyrano[3,2-d][1,3]thiazole-6,7-diol pubchem.compound:24808478 (3aR,5R,6S,7R,7aR)-2-(ethylamino)-5-(hydroxymethyl)-3a,6,7,7a-tetrahydro-5H-pyrano[3,2-d]thiazole-6,7-diol pubchem.compound:24808478 (3aR,5R,6S,7R,7aR)-2-(Ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol pubchem.compound:24808478 (3aR)-2-(Ethylamino)-6beta,7alpha-dihydroxy-3aalpha,6,7,7aalpha-tetrahydro-5H-pyrano[3,2-d]thiazole-5alpha-methanol pubchem.compound:24808478 Thioacetic acid S-[(S)-6-[[(R)-5-oxopyrrolidine-2-ylcarbonyl]amino]-6-(phenylcarbamoyl)hexyl] ester pubchem.compound:71538210 ST-7612AA1 pubchem.compound:71538210 SCHEMBL14812001 pubchem.compound:71538210 SB17083 pubchem.compound:71538210 CHEMBL3353926 pubchem.compound:71538210 BDBM50027652 pubchem.compound:71538210 A14418 pubchem.compound:71538210 1428535-92-5 pubchem.compound:71538210 s1066 pubchem.compound:9549284 alpha-{amino[(4-aminophenyl)thio]methylene}-2-(trifluoromethyl)benzeneacetonitrile pubchem.compound:9549284 alpha-[Amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile pubchem.compound:9549284 ZINC1910234 pubchem.compound:9549284 Z-& E-alpha-(Amino-((4-aminophenyl)thio)methylene)-2-(trifluoromethyl)benzeneacetonitrile pubchem.compound:9549284 Z-& E-a-(Amino-((4-aminophenyl)thio)methylene)-2-(trifluoromethyl)benzeneacetonitrile pubchem.compound:9549284 X3440 pubchem.compound:9549284 W-5333 pubchem.compound:9549284 SW219839-1 pubchem.compound:9549284 SL327, >=98% (HPLC), Mixture of E & Z isomers, solid pubchem.compound:9549284 SL327 pubchem.compound:9549284 SL-327 pubchem.compound:9549284 SL 327 pubchem.compound:9549284 SCHEMBL570318 pubchem.compound:9549284 SCHEMBL570317 pubchem.compound:9549284 SB19419 pubchem.compound:9549284 NCGC00092290-02 pubchem.compound:9549284 NCGC00092290-01 pubchem.compound:9549284 MolPort-006-069-021 pubchem.compound:9549284 MFCD06411432 pubchem.compound:9549284 MEK1/2 Inhibitor orcid:0000-0001-9439-5346 LS-193345 pubchem.compound:9549284 KB-80585 pubchem.compound:9549284 K00090 pubchem.compound:9549284 JLOXTZFYJNCPIS-FYWRMAATSA-N pubchem.compound:9549284 J-018001 pubchem.compound:9549284 HY-15437 pubchem.compound:9549284 HSCI1_000044 pubchem.compound:9549284 HMS3678M21 pubchem.compound:9549284 HMS3229K18 pubchem.compound:9549284 GTPL6008 pubchem.compound:9549284 EX-A1069 pubchem.compound:9549284 EC-000.2354 pubchem.compound:9549284 E/Z-a-[amino[(4-aminophenyl)thio]methylen]-2-(trifluoromethyl)benzeneacetonitrile pubchem.compound:9549284 DTXSID90429549 pubchem.compound:9549284 D04WPA pubchem.compound:9549284 CS-0910 pubchem.compound:9549284 CHEBI:92211 pubchem.compound:9549284 CCG-206867 pubchem.compound:9549284 Benzeneacetonitrile, alpha-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)- pubchem.compound:9549284 BRD-K12244279-001-01-7 pubchem.compound:9549284 BCP05310 pubchem.compound:9549284 BC600460 pubchem.compound:9549284 AOB5954 pubchem.compound:9549284 AKOS024456884 pubchem.compound:9549284 305350-87-2 pubchem.compound:9549284 3-amino-3-[(4-aminophenyl)thio]-2-[2-(trifluoromethyl)phenyl]-2-propenenitrile pubchem.compound:9549284 3-amino-3-[(4-aminophenyl)sulfanyl]-2-[2-(trifluoromethyl)phenyl]acrylonitrile pubchem.compound:9549284 3-amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile pubchem.compound:9549284 (Z)-3-amino-3-(4-aminophenylthio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile pubchem.compound:9549284 (2Z)-3-amino-3-[(4-aminophenyl)sulfanyl]-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile pubchem.compound:9549284 s7229 pubchem.compound:56650312 ZINC95616594 pubchem.compound:56650312 SW219401-1 pubchem.compound:56650312 SCHEMBL12497871 pubchem.compound:56650312 SCHEMBL12497867 pubchem.compound:56650312 SB19284 pubchem.compound:56650312 RGFP966, >=98% (HPLC) pubchem.compound:56650312 RGFP966 Racemate pubchem.compound:56650312 RGFP966 pubchem.compound:56650312 RGFP-966 pubchem.compound:56650312 RGFP 966 pubchem.compound:56650312 QC-11774 pubchem.compound:56650312 MolPort-035-395-807 pubchem.compound:56650312 MFCD26960954 pubchem.compound:56650312 KB-148638 pubchem.compound:56650312 J-007305 pubchem.compound:56650312 GTPL7500 pubchem.compound:56650312 EX-A229 pubchem.compound:56650312 DA-45706 pubchem.compound:56650312 DA-45384 pubchem.compound:56650312 D00HXX pubchem.compound:56650312 CHEMBL4078477 pubchem.compound:56650312 CHEBI:131163 pubchem.compound:56650312 C21H19FN4O pubchem.compound:56650312 BLVQHYHDYFTPDV-VCABWLAWSA-N pubchem.compound:56650312 BCP08102 pubchem.compound:56650312 BC600495 pubchem.compound:56650312 AKOS030526449 pubchem.compound:56650312 AK676067 pubchem.compound:56650312 A13218 pubchem.compound:56650312 2686AH pubchem.compound:56650312 2-Propenamide, N-(2-amino-4-fluorophenyl)-3-[1-[(2E)-3-phenyl-2-propen-1-yl]-1H-pyrazol-4-yl]-, (2E)- pubchem.compound:56650312 1396841-57-8 pubchem.compound:56650312 1357389-11-7 pubchem.compound:56650312 (E)-N-(2-amino-4-fluorophenyl)-3-(1-cinnamyl-1H-pyrazol-4-yl)acrylamide pubchem.compound:56650312 (2E)-N-(2-amino-4-fluorophenyl)-3-{1-[(2E)-3-phenylprop-2-en-1-yl]-1H-pyrazol-4-yl}prop-2-enamide pubchem.compound:56650312 ldn-193594 pubchem.compound:54581340 ZINC71317068 pubchem.compound:54581340 XHJMMMPXTUEBMQ-UHFFFAOYSA-N pubchem.compound:54581340 NSC747885 pubchem.compound:54581340 NSC-747885 pubchem.compound:54581340 KB-274259 pubchem.compound:54581340 CHEMBL1761791 pubchem.compound:54581340 BDBM50340902 pubchem.compound:54581340 1289638-15-8 pubchem.compound:54581340 (4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(2-fluorophenyl)methanone pubchem.compound:54581340 ZINC38760485 pubchem.compound:10397232 SCHEMBL793684 pubchem.compound:10397232 MolPort-019-997-392 pubchem.compound:10397232 MFCD06208438 pubchem.compound:10397232 MCULE-2720405682 pubchem.compound:10397232 KB-106928 pubchem.compound:10397232 K-8942 pubchem.compound:10397232 IGZSSKAOSOCVPH-UHFFFAOYSA-N pubchem.compound:10397232 FT-0718529 pubchem.compound:10397232 F9995-2550 pubchem.compound:10397232 DTXSID30439182 pubchem.compound:10397232 DB-070534 pubchem.compound:10397232 CTK4I8112 pubchem.compound:10397232 CM-414 pubchem.compound:10397232 AKOS010054622 pubchem.compound:10397232 AJ-96850 pubchem.compound:10397232 AB1552 pubchem.compound:10397232 AB0085720 pubchem.compound:10397232 A826542 pubchem.compound:10397232 4868AH pubchem.compound:10397232 4432-44-4 pubchem.compound:10397232 4-Morpholinepropanoicacid, a-methylene- pubchem.compound:10397232 2-morpholin-4ylmethyl-2-propenoic acid pubchem.compound:10397232 2-morpholin-4-ylmethyl-2-propenoic acid pubchem.compound:10397232 2-[(morpholin-4-yl)methyl]prop-2-enoic acid pubchem.compound:10397232 2-Morpholin4-ylmethyl-acrylic acid pubchem.compound:10397232 2-MORPHOLIN-4-YLMETHYL-ACRYLIC ACID pubchem.compound:10397232 2-(morpholin-4-ylmethyl)prop-2-enoic Acid pubchem.compound:10397232 2-(Morpholinomethyl)propenoic acid pubchem.compound:10397232 2-(Morpholinomethyl)acrylic acid pubchem.compound:10397232 2-(4-morpholinylmethyl)-2-propenoic acid pubchem.compound:10397232 dibenzo-(b,f)oxepin-10-ylmethyl-methyl-prop-2-ynyl-amine pubchem.compound:6419718 dibenz[b,f]oxepin-10-ylmethyl-N-methyl-N-prop-2-ynylamine pubchem.compound:6419718 ZINC33943510 pubchem.compound:6419718 UNII-5V14HD0N4Q pubchem.compound:6419718 Tch 346 pubchem.compound:6419718 TCH346 pubchem.compound:6419718 TCH-346B pubchem.compound:6419718 TCH-346 pubchem.compound:6419718 SNT-317 pubchem.compound:6419718 SCHEMBL333032 pubchem.compound:6419718 QLMMOGWZCFQAPU-UHFFFAOYSA-N pubchem.compound:6419718 Omigapil) pubchem.compound:6419718 Omigapil [INN] pubchem.compound:6419718 Omigapil pubchem.compound:6419718 Nootropicagent, Santhera pubchem.compound:6419718 Nootropic agent, Novartis pubchem.compound:6419718 Neuroprotectant, Santhera pubchem.compound:6419718 Neuroprotectant, Novartis pubchem.compound:6419718 NCGC00346431-01 pubchem.compound:6419718 N-(dibenzo[b,f]oxepin-10-ylmethyl)-N-methylprop-2-yn-1-amine pubchem.compound:6419718 N-(benzo[b][1]benzoxepin-5-ylmethyl)-N-methylprop-2-yn-1-amine pubchem.compound:6419718 N-(DIBENZO[B,F]OXEPIN-10-YLMETHYL)-N-METHYL-N-PROP-2-YNYLAMINE pubchem.compound:6419718 Dibenzo(b,f)oxepin-10-ylmethyl-methyl-prop-2-ynylamine pubchem.compound:6419718 DTXSID10171098 pubchem.compound:6419718 DB12879 pubchem.compound:6419718 D06KSV pubchem.compound:6419718 CHEMBL1232111 pubchem.compound:6419718 CHEBI:41778 pubchem.compound:6419718 CGP-3499B pubchem.compound:6419718 CGP-3466 pubchem.compound:6419718 CGP 3466 pubchem.compound:6419718 AC1O4WBX pubchem.compound:6419718 634202-78-1 pubchem.compound:6419718 5V14HD0N4Q pubchem.compound:6419718 181296-84-4 pubchem.compound:6419718 (Dibenzo(b,f)oxepin-5-ylmethyl)(methyl)prop-2-yn-1-amine pubchem.compound:6419718 ZINC13838357 pubchem.compound:1285940 STK219801 pubchem.compound:1285940 SCHEMBL14991291 pubchem.compound:1285940 MolPort-002-976-806 pubchem.compound:1285940 KB-145969 pubchem.compound:1285940 HY-13823 pubchem.compound:1285940 EX-A1063 pubchem.compound:1285940 CS-3529 pubchem.compound:1285940 CHEMBL3734823 pubchem.compound:1285940 C646 pubchem.compound:1285940 C-646 pubchem.compound:1285940 C 646 pubchem.compound:1285940 BRD-K68548958-001-01-2 pubchem.compound:1285940 BC600370 pubchem.compound:1285940 AOB5549 pubchem.compound:1285940 AKOS005418912 pubchem.compound:1285940 AC1LPE4S pubchem.compound:1285940 4-[(4E)-4-{[5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl]methylidene}-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid pubchem.compound:1285940 4-[(4E)-4-[[5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid pubchem.compound:1285940 4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid pubchem.compound:1285940 328968-36-1 pubchem.compound:1285940 (E)-4-(4-((5-(4,5-diMethyl-2-nitrophenyl)furan-2-yl)Methylene)-3-Methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid pubchem.compound:1285940 cc-526 pubchem.compound:10200390 ZINC3817793 pubchem.compound:10200390 UNII-61G8S0H9KX pubchem.compound:10200390 Syk inhibitor IV pubchem.compound:10200390 SCHEMBL373774 pubchem.compound:10200390 RL04784 pubchem.compound:10200390 NCGC00346945-06 pubchem.compound:10200390 NCGC00346945-01 pubchem.compound:10200390 Kinome_3125 pubchem.compound:10200390 KB-74859 pubchem.compound:10200390 J-507625 pubchem.compound:10200390 HY-76474 pubchem.compound:10200390 GTPL9693 pubchem.compound:10200390 EX-A1437 pubchem.compound:10200390 CS-0235 pubchem.compound:10200390 CHEMBL1242100 pubchem.compound:10200390 CHEMBL1190711 pubchem.compound:10200390 CHEBI:91426 pubchem.compound:10200390 CCG-102604 pubchem.compound:10200390 BRD-K53281329-001-01-9 pubchem.compound:10200390 BDBM50325991 pubchem.compound:10200390 BCP08946 pubchem.compound:10200390 BAY61-3606 pubchem.compound:10200390 BAY-613606 pubchem.compound:10200390 BAY-61-3606 free base pubchem.compound:10200390 BAY-61-360 pubchem.compound:10200390 BAY 61-3606 HCl pubchem.compound:10200390 BAY 61-3606 pubchem.compound:10200390 AKOS030526888 pubchem.compound:10200390 ACN-053214 pubchem.compound:10200390 AC-29888 pubchem.compound:10200390 A11320 pubchem.compound:10200390 732983-37-8 pubchem.compound:10200390 61G8S0H9KX pubchem.compound:10200390 3-Pyridinecarboxamide, 2-((7-(3,4-dimethoxyphenyl)imidazo(1,2-C)pyrimidin-5-yl)amino)- pubchem.compound:10200390 2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide pubchem.compound:10200390 2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidine-5-yl]amino]-3-pyridinecarboxamide pubchem.compound:10200390 2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide pubchem.compound:10200390 2-(7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-ylamino)nicotinamide hydrochloride pubchem.compound:10200390 2-((7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl)amino)nicotinamide pubchem.compound:10200390 s8001 pubchem.compound:53340666 rocilinostat-acy-1215 pubchem.compound:53340666 ZINC89630354 pubchem.compound:53340666 X5832 pubchem.compound:53340666 WKT909C62B pubchem.compound:53340666 W-5979 pubchem.compound:53340666 US8609678, 2-(diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide [26] pubchem.compound:53340666 UNII-WKT909C62B pubchem.compound:53340666 SW219836-1 pubchem.compound:53340666 ST24039648 pubchem.compound:53340666 SMR004702950 pubchem.compound:53340666 SCHEMBL574580 pubchem.compound:53340666 SB17054 pubchem.compound:53340666 Rocilinostat (ACY-1215) pubchem.compound:53340666 Rocilinostat pubchem.compound:53340666 Ricolinostat [USAN:INN] pubchem.compound:53340666 Ricolinostat (USAN/INN) pubchem.compound:53340666 Ricolinostat (ACY-1215) pubchem.compound:53340666 Ricolinostat pubchem.compound:53340666 NCGC00345802-05 pubchem.compound:53340666 NCGC00345802-01 pubchem.compound:53340666 N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)pyrimidine-5-carboxamide pubchem.compound:53340666 MolPort-028-600-031 pubchem.compound:53340666 MLS006011181 pubchem.compound:53340666 MFCD22666356 pubchem.compound:53340666 KS-00000SAV pubchem.compound:53340666 KB-74507 pubchem.compound:53340666 J-690127 pubchem.compound:53340666 HY-16026 pubchem.compound:53340666 HMS3653F17 pubchem.compound:53340666 GTPL7010 pubchem.compound:53340666 EX-A139 pubchem.compound:53340666 DTXSID40157148 pubchem.compound:53340666 DB12376 pubchem.compound:53340666 D10661 pubchem.compound:53340666 D0TP9M pubchem.compound:53340666 CS-0965 pubchem.compound:53340666 CHEMBL2364628 pubchem.compound:53340666 CHEBI:95073 pubchem.compound:53340666 BDBM50439674 pubchem.compound:53340666 BCP06028 pubchem.compound:53340666 BC600387 pubchem.compound:53340666 AX8288032 pubchem.compound:53340666 AKOS024259260 pubchem.compound:53340666 AK151416 pubchem.compound:53340666 AJ-128539 pubchem.compound:53340666 AH4 pubchem.compound:53340666 ACY1215 pubchem.compound:53340666 ACY-63 pubchem.compound:53340666 ACY-1215 pubchem.compound:53340666 ACN-030031 pubchem.compound:53340666 AC-30258 pubchem.compound:53340666 AB0032517 pubchem.compound:53340666 A11940 pubchem.compound:53340666 7-{[2-(DIPHENYLAMINO)PYRIMIDIN-5-YL]FORMAMIDO}-N-HYDROXYHEPTANAMIDE pubchem.compound:53340666 5-Pyrimidinecarboxamide, 2-(diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]- pubchem.compound:53340666 5-Pyrimidinecarboxamide, 2-(diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)- pubchem.compound:53340666 2-(diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]pyrimidine-5-carboxamide pubchem.compound:53340666 2-(Diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide pubchem.compound:53340666 2-(Diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide pubchem.compound:53340666 1316214-52-4 pubchem.compound:53340666 bromohexadecanoic acid pubchem.compound:82145 alpha-Bromopalmitic acid pubchem.compound:82145 ZX-AT022731 pubchem.compound:82145 VZ24096 pubchem.compound:82145 Tox21_301033 pubchem.compound:82145 TRA0083226 pubchem.compound:82145 TC-170832 pubchem.compound:82145 ST45026694 pubchem.compound:82145 SCHEMBL97565 pubchem.compound:82145 SBB071635 pubchem.compound:82145 OR10833 pubchem.compound:82145 NSC58378 pubchem.compound:82145 NSC-58378 pubchem.compound:82145 NSC 58378 pubchem.compound:82145 NCIOpen2_007723 pubchem.compound:82145 NCGC00254935-01 pubchem.compound:82145 NCGC00164251-02 pubchem.compound:82145 NCGC00164251-01 pubchem.compound:82145 MolPort-001-759-724 pubchem.compound:82145 MFCD00004215 pubchem.compound:82145 MCULE-7613431163 pubchem.compound:82145 LS-174823 pubchem.compound:82145 LMFA01090011 pubchem.compound:82145 L213 pubchem.compound:82145 KB-68336 pubchem.compound:82145 J-011689 pubchem.compound:82145 I04-8986 pubchem.compound:82145 Hexadecanoic acid,2-bromo- pubchem.compound:82145 Hexadecanoic acid, 2-bromo- pubchem.compound:82145 FT-0611564 pubchem.compound:82145 EINECS 242-137-0 pubchem.compound:82145 DTXSID0037734 pubchem.compound:82145 DSSTox_RID_79368 pubchem.compound:82145 DSSTox_GSID_37734 pubchem.compound:82145 DSSTox_CID_17734 pubchem.compound:82145 DPRAYRYQQAXQPE-UHFFFAOYSA-N pubchem.compound:82145 DB-044471 pubchem.compound:82145 CTK4D8252 pubchem.compound:82145 CHEMBL118417 pubchem.compound:82145 CHEBI:133152 pubchem.compound:82145 CC-09685 pubchem.compound:82145 CAS-18263-25-7 pubchem.compound:82145 C16H31BrO2 pubchem.compound:82145 C-20189 pubchem.compound:82145 BDBM50148454 pubchem.compound:82145 AKOS017343270 pubchem.compound:82145 AKOS003404931 pubchem.compound:82145 ACMC-1C7OL pubchem.compound:82145 ACM18263257 pubchem.compound:82145 AC1Q2444 pubchem.compound:82145 AC1L32UD pubchem.compound:82145 A812715 pubchem.compound:82145 40305-76-8 pubchem.compound:82145 2-bromopalmitate, (+-)-isomer pubchem.compound:82145 2-bromo-hexadecanoic acid pubchem.compound:82145 2-bromanylhexadecanoic acid pubchem.compound:82145 2-Bromopalmitic acid pubchem.compound:82145 2-Bromopalmitate pubchem.compound:82145 2-Bromohexadecanoic acid, ~97% pubchem.compound:82145 2-Bromohexadecanoic acid, purum, >=97.0% (GC) pubchem.compound:82145 2-Bromohexadecanoic acid, >=99.0% (GC) pubchem.compound:82145 2-Bromohexadecanoic acid pubchem.compound:82145 18263-25-7 pubchem.compound:82145 .alpha.-Bromopalmitic acid pubchem.compound:82145 ethyl 4-(2-benzamidoethylamino)piperidine-1-carboxylate hydrochloride pubchem.compound:25010774 VU0184670 pubchem.compound:25010774 SMR001318088 pubchem.compound:25010774 MLS002279950 pubchem.compound:25010774 CHEMBL1535797 pubchem.compound:25010774 1135241-95-0 pubchem.compound:25010774 cyclopentyl 3,4-dimethyl-6-(6-nitro-1,3-benzodioxol-5-yl)-2-oxo-1,6-dihydropyrimidine-5-carboxylate pubchem.compound:2882724 cyclopentyl 1,6-dimethyl-4-(6-nitrobenzo[d][1,3]-dioxol-5-yl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate pubchem.compound:2882724 cyclopentyl 1,6-dimethyl-4-(6-nitrobenzo[d][1,3]-dioxol-5-yl)-2-oxo-1,2,3,4 tetrahydropyrimidine-5-carboxylate pubchem.compound:2882724 cyclopentyl 1,6-dimethyl-4-(6-nitro-1,3-benzodioxol-5-yl)-2-oxo-3,4-dihydropyrimidine-5-carboxylate pubchem.compound:2882724 cyclopentyl 1,6-dimethyl-4-(6-nitro-1,3-benzodioxol-5-yl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate pubchem.compound:2882724 VU0090157 pubchem.compound:2882724 UNM000000551301 pubchem.compound:2882724 STK079398 pubchem.compound:2882724 SR-01000433423-1 pubchem.compound:2882724 SR-01000433423 pubchem.compound:2882724 Oprea1_103541 pubchem.compound:2882724 MolPort-002-181-662 pubchem.compound:2882724 MCULE-4339280714 pubchem.compound:2882724 GTPL3259 pubchem.compound:2882724 EU-0038260 pubchem.compound:2882724 D0O6BD pubchem.compound:2882724 CBMicro_042727 pubchem.compound:2882724 BIM-0042576.P001 pubchem.compound:2882724 AKOS022078796 pubchem.compound:2882724 AKOS001633711 pubchem.compound:2882724 AC1MER3E pubchem.compound:2882724 ZINC38534584 pubchem.compound:6758210 ZINC1204219 pubchem.compound:6758210 KS-000046FP pubchem.compound:6758210 D0L5AG pubchem.compound:6758210 BCP17383 pubchem.compound:6758210 AOB2484 pubchem.compound:6758210 AKOS028114549 pubchem.compound:6758210 326001-01-8 pubchem.compound:6758210 2-[(4-ethoxyphenyl)amino]-N'-[(2-hydroxy-1-naphthyl)methylene]acetohydrazide (non-preferred name) pubchem.compound:6758210 2-(4-ethoxyanilino)-N'-[(E)-(2-oxonaphthalen-1-ylidene)methyl]acetohydrazide pubchem.compound:6758210 cid_1541501 pubchem.compound:1541501 ZINC1472126 pubchem.compound:1541501 VU0152099-1 pubchem.compound:1541501 VU0152099 pubchem.compound:1541501 STK207844 pubchem.compound:1541501 SMR001398665 pubchem.compound:1541501 Oprea1_621562 pubchem.compound:1541501 MolPort-000-437-290 pubchem.compound:1541501 MLS002474500 pubchem.compound:1541501 MCULE-6171593814 pubchem.compound:1541501 HMS3843E06 pubchem.compound:1541501 GTPL3256 pubchem.compound:1541501 D0Y1VB pubchem.compound:1541501 BDBM48044 pubchem.compound:1541501 AKOS002170228 pubchem.compound:1541501 AC1Q2P5R pubchem.compound:1541501 AC1LTW64 pubchem.compound:1541501 612514-42-8 pubchem.compound:1541501 3-azanyl-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxamide pubchem.compound:1541501 3-amino-N-(benzo[d][1,3]dioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine carboxamide pubchem.compound:1541501 3-amino-N-(2H-1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide pubchem.compound:1541501 3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[5,4-b]pyridine-2-carboxamide pubchem.compound:1541501 3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide pubchem.compound:1541501 3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethyl-2-thieno[2,3-b]pyridinecarboxamide pubchem.compound:1541501 3-amino-4,6-dimethyl-N-piperonyl-thieno[2,3-b]pyridine-2-carboxamide pubchem.compound:1541501 VU0456940 https://medkoo.com/products/9998 VU-0456940 https://medkoo.com/products/9998 VU 0456940 https://medkoo.com/products/9998 f-LIGRLO-NH2 pubchem.compound:714286 cid_714286 pubchem.compound:714286 ZINC109066 pubchem.compound:714286 VU10010 pubchem.compound:714286 VU0402469-1 pubchem.compound:714286 VU-10010 pubchem.compound:714286 VU 10010 pubchem.compound:714286 STL227650 pubchem.compound:714286 SR-01000147542-1 pubchem.compound:714286 SR-01000147542 pubchem.compound:714286 SMR001398666 pubchem.compound:714286 RT-016241 pubchem.compound:714286 NCGC00378784-01 pubchem.compound:714286 MolPort-002-722-568 pubchem.compound:714286 MLS002474501 pubchem.compound:714286 MCULE-8947006791 pubchem.compound:714286 KB-81468 pubchem.compound:714286 HMS3431D09 pubchem.compound:714286 FPRULFHDSFKYBV-UHFFFAOYSA-N pubchem.compound:714286 DTXSID30351931 pubchem.compound:714286 D0N2VN pubchem.compound:714286 CTK5B8654 pubchem.compound:714286 CHEMBL1212994 pubchem.compound:714286 BDBM50323691 pubchem.compound:714286 B7285 pubchem.compound:714286 AKOS000282930 pubchem.compound:714286 AC1LEM0C pubchem.compound:714286 A3274/0139289 pubchem.compound:714286 633283-39-3 pubchem.compound:714286 3-amino-N-[(4-chlorophenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide pubchem.compound:714286 3-amino-N-(4-chlorobenzyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide pubchem.compound:714286 3-Amino-N-(4-chlorobenzyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide 2,2,2-trifluoroacetate pubchem.compound:714286 2fLI pubchem.compound:714286 2-fAP pubchem.compound:714286 2-f-LIGRLO-NH2 pubchem.compound:714286 2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2 trifluoroacetate salt pubchem.compound:714286 2-Furoyl-LIGRLO-amide trifluoroacetate salt, >=97% (HPLC) pubchem.compound:714286 2-Furoyl-LIGRLO-amide trifluoroacetate salt pubchem.compound:714286 2-Fly pubchem.compound:714286 PRD pubmed:26789759 P domain pubmed:8068626 SEC-R ? microtubule-associated protein tau isoform 5 ? htau34 pubmed:22762014 1N4R ? microtubule-associated protein tau isoform 8 ? htau39 pubmed:22762014 2N3R ? microtubule-associated protein tau isoform 3 ? htau24 pubmed:22762014 0N4R ? microtubule-associated protein tau isoform 7 ? htau37 pubmed:22762014 1N3R ? microtubule-associated protein tau isoform 4 ? htau23 pubmed:7667312 0N3R ? microtubule-associated protein tau isoform 2 ? htau40 pubmed:19226187 2N4R ? MAP2/Tau projection ? PHF6 pubmed:25775228 PHF6* pubmed:25775228 soluble amyloid precursor protein ? YENPTY ? GVD ? AGD ? [Pro3]-GIP (Rat) pubchem.compound:131954578 AKOS034831571 pubchem.compound:131954578 ADDL pubmed:16712494 ZINC97971833 pubchem.compound:16394575 UNII-9BU4T267E4 pubchem.compound:16394575 Spirost-5-en-3-ol, 3-hexanoate, (3beta,25R)- pubchem.compound:16394575 SP-233 pubchem.compound:16394575 SP-223 pubchem.compound:16394575 MolPort-002-507-344 pubchem.compound:16394575 MCULE-6852340934 pubchem.compound:16394575 J2.343.184J pubchem.compound:16394575 Diosgenin, hexanoate pubchem.compound:16394575 Diosgenin caproate pubchem.compound:16394575 DB05263 pubchem.compound:16394575 CAPROSPINOL pubchem.compound:16394575 AKOS015955746 pubchem.compound:16394575 9BU4T267E4 pubchem.compound:16394575 4952-56-1 pubchem.compound:16394575 (3beta,8xi,9xi,14xi,16xi,17xi,20R,22xi,25R)-Spirost-5-en-3-yl hexanoa pubchem.compound:16394575 (22R,25R)-20alpha-Spirost-5-en-3beta-yl hexanoate pubchem.compound:16394575 ((20S,22R,25R)-Spirosta-5-ene-3beta-ol)hexanoate pubchem.compound:16394575 ethyl 5-amino-4-oxo-3-phenylthieno[3,4-d]pyridazine-1-carboxylate pubchem.compound:647821 ethyl 5-amino-4-oxo-3-phenyl-3H,4H-thieno[3,4-d]pyridazine-1-carboxylate pubchem.compound:647821 ethyl 5-amino-4-oxo-3-phenyl-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate pubchem.compound:647821 ZINC563211 pubchem.compound:647821 SMR000013604 pubchem.compound:647821 SCHEMBL7885074 pubchem.compound:647821 NCGC00031883-02 pubchem.compound:647821 MolPort-001-835-700 pubchem.compound:647821 MLS002539346 pubchem.compound:647821 MLS000034832 pubchem.compound:647821 MCULE-6208802152 pubchem.compound:647821 L-4233 pubchem.compound:647821 HMS2339G13 pubchem.compound:647821 HMS1616C21 pubchem.compound:647821 HLVGVGCIJRBRQW-UHFFFAOYSA-N pubchem.compound:647821 F2135-0238 pubchem.compound:647821 CHEMBL461431 pubchem.compound:647821 CCG-115473 pubchem.compound:647821 BDBM50253793 pubchem.compound:647821 BAS 06046551 pubchem.compound:647821 AKOS000601368 pubchem.compound:647821 AC1Q34EJ pubchem.compound:647821 AC1LDGR2 pubchem.compound:647821 5-Amino-4-oxo-3-phenyl-3,4-dihydro-thieno[3,4-d]pyridazine-1-carboxylic acid ethyl ester pubchem.compound:647821 5-Amino-4-oxo-3-phenyl-3,4-dihydro-thieno[3,4-d]pyridazine-1-carboxylic acid eth pubchem.compound:647821 3-Phenyl-4-oxo-5-amino-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylic acid ethyl ester pubchem.compound:647821 123542-47-2 pubchem.compound:647821 ZINC49582255 pubchem.compound:46835756 TC-064564 pubchem.compound:46835756 SEN 1269 pubchem.compound:46835756 SCHEMBL3602388 pubchem.compound:46835756 NCGC00387448-01 pubchem.compound:46835756 MolPort-009-685-119 pubchem.compound:46835756 MFPAAKZZUIRMKR-UHFFFAOYSA-N pubchem.compound:46835756 I06-2365 pubchem.compound:46835756 FT-0682533 pubchem.compound:46835756 DTXSID40676566 pubchem.compound:46835756 DB-080315 pubchem.compound:46835756 CTK5H7888 pubchem.compound:46835756 CHEMBL2386874 pubchem.compound:46835756 AKOS015850742 pubchem.compound:46835756 A11161 pubchem.compound:46835756 956128-01-1 pubchem.compound:46835756 4350AF pubchem.compound:46835756 3-[[5-[3-(dimethylamino)phenoxy]-2-pyrimidinyl]amino]phenol pubchem.compound:46835756 3-({5-[3-(dimethylamino)phenoxy]pyrimidin-2-yl}amino)phenol pubchem.compound:46835756 3-(5-(3-(dimethylamino)phenoxy)pyrimidin-2-ylamino)phenol pubchem.compound:46835756 3-((5-(3-(Dimethylamino)phenoxy)pyrimidin-2-yl)amino)phenol pubchem.compound:46835756 membrane nanotube ? TNT ? ME ? CCH ? Low-power laser irradiation ? s1105 pubchem.compound:3973 cc-58 pubchem.compound:3973 ZX-AFC000490 pubchem.compound:3973 ZINC6014 pubchem.compound:3973 X7411 pubchem.compound:3973 UNII-31M2U1DVID pubchem.compound:3973 Tocris-1130 pubchem.compound:3973 SYN1108 pubchem.compound:3973 SW217688-2 pubchem.compound:3973 ST24040926 pubchem.compound:3973 SR-01000076245-7 pubchem.compound:3973 SMR002530642 pubchem.compound:3973 SF-1101 pubchem.compound:3973 SF 1101 pubchem.compound:3973 SCHEMBL94377 pubchem.compound:3973 SC-85850 pubchem.compound:3973 SB10965 pubchem.compound:3973 S-7706 pubchem.compound:3973 RT-013609 pubchem.compound:3973 RS0074 pubchem.compound:3973 QC-7260 pubchem.compound:3973 PubChem16766 pubchem.compound:3973 NSC697286 pubchem.compound:3973 NSC-697286 pubchem.compound:3973 NSC 697286 pubchem.compound:3973 NCI60_034712 pubchem.compound:3973 NCGC00179253-01 pubchem.compound:3973 NCGC00025020-04 pubchem.compound:3973 NCGC00025020-03 pubchem.compound:3973 NCGC00025020-02 pubchem.compound:3973 NCGC00025020-01 pubchem.compound:3973 NCGC00015622-07 pubchem.compound:3973 NCGC00015622-06 pubchem.compound:3973 NCGC00015622-05 pubchem.compound:3973 NCGC00015622-04 pubchem.compound:3973 NCGC00015622-03 pubchem.compound:3973 NCGC00015622-02 pubchem.compound:3973 NCGC00015622-01 pubchem.compound:3973 MolPort-003-983-779 pubchem.compound:3973 MLS006010131 pubchem.compound:3973 M2410 pubchem.compound:3973 Lys 294002 pubchem.compound:3973 Lopac0_000710 pubchem.compound:3973 Lopac-L-9908 pubchem.compound:3973 LY294002 pubchem.compound:3973 LY2 pubchem.compound:3973 LY-924002 pubchem.compound:3973 LY-294002 pubchem.compound:3973 LY-294,002 hydrochloride, solid, >=98% (HPLC) pubchem.compound:3973 LY-294,002 pubchem.compound:3973 LY 294002; 2-(4-Morpholino)-8-phenyl-4H-1-benzopyran-4-one pubchem.compound:3973 LY 294002, LY-294002, 154447-36-6 pubchem.compound:3973 LY 294002 pubchem.compound:3973 LS-39828 pubchem.compound:3973 Kinome_3543 pubchem.compound:3973 KS-00000XP3 pubchem.compound:3973 KBioSS_000563 pubchem.compound:3973 KBioGR_000563 pubchem.compound:3973 KBio3_001006 pubchem.compound:3973 KBio3_001005 pubchem.compound:3973 KBio2_005699 pubchem.compound:3973 KBio2_003131 pubchem.compound:3973 KBio2_000563 pubchem.compound:3973 KB-231805 pubchem.compound:3973 KB-19284 pubchem.compound:3973 K00235 pubchem.compound:3973 J-510126 pubchem.compound:3973 InSolution™ LY 294002 pubchem.compound:3973 IN1268 pubchem.compound:3973 IN1266 pubchem.compound:3973 IDI1_002197 pubchem.compound:3973 HY-10108 pubchem.compound:3973 HSCI1_000206 pubchem.compound:3973 HMS3654M21 pubchem.compound:3973 HMS3649E04 pubchem.compound:3973 HMS3403M05 pubchem.compound:3973 HMS3229G17 pubchem.compound:3973 HMS1990M05 pubchem.compound:3973 HMS1792M05 pubchem.compound:3973 HMS1362M05 pubchem.compound:3973 H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-(9CI) pubchem.compound:3973 H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl- (9CI) pubchem.compound:3973 GTPL6004 pubchem.compound:3973 FT-0660382 pubchem.compound:3973 EX-A073 pubchem.compound:3973 EC-000.2341 pubchem.compound:3973 DTXSID6042650 pubchem.compound:3973 DB02656 pubchem.compound:3973 D0X7NA pubchem.compound:3973 D09SFV pubchem.compound:3973 CZQHHVNHHHRRDU-UHFFFAOYSA-N pubchem.compound:3973 CTK0H1979 pubchem.compound:3973 CS-0150 pubchem.compound:3973 CHEMBL98350 pubchem.compound:3973 CHEBI:65329 pubchem.compound:3973 CCG-100633 pubchem.compound:3973 CBiol_002046 pubchem.compound:3973 C15195 pubchem.compound:3973 BiomolKI_000029 pubchem.compound:3973 BiomolKI2_000037 pubchem.compound:3973 Bio2_000922 pubchem.compound:3973 Bio2_000442 pubchem.compound:3973 Bio1_001310 pubchem.compound:3973 Bio1_000821 pubchem.compound:3973 Bio1_000332 pubchem.compound:3973 BSPBio_001223 pubchem.compound:3973 BRD-K27305650-001-05-9 pubchem.compound:3973 BMK1-D5 pubchem.compound:3973 BIL2940 pubchem.compound:3973 BDBM12915 pubchem.compound:3973 BCPP000177 pubchem.compound:3973 BCP9000880 pubchem.compound:3973 BCP00195 pubchem.compound:3973 BCBcMAP01_000117 pubchem.compound:3973 BC660045 pubchem.compound:3973 AS-16252 pubchem.compound:3973 API0015880 pubchem.compound:3973 AN-1305 pubchem.compound:3973 AKOS017344742 pubchem.compound:3973 AK162301 pubchem.compound:3973 AC1Q6CLU pubchem.compound:3973 AC1L1H4N pubchem.compound:3973 AC-30295 pubchem.compound:3973 AB0033714 pubchem.compound:3973 8-Phenyl-2-(morpholin-4-yl)-chromen-4-one pubchem.compound:3973 4azt pubchem.compound:3973 4H-1-Benzopyran-4-one,2-(4-morpholinyl)-8-phenyl- pubchem.compound:3973 4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-(9CI) pubchem.compound:3973 4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl- (9CI) pubchem.compound:3973 4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl- pubchem.compound:3973 4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl pubchem.compound:3973 4CA-0787 pubchem.compound:3973 31M2U1DVID pubchem.compound:3973 2-morpholino-8-phenyl-chromen-4-one pubchem.compound:3973 2-morpholino-8-phenyl-4H-chromen-4-one pubchem.compound:3973 2-morpholin-4-yl-8-phenylchromen-4-one pubchem.compound:3973 2-morpholin-4-yl-8-phenyl-4H-chromen-4-one pubchem.compound:3973 2-Morpholino-8-phenylchromone pubchem.compound:3973 2-Morpholino-8-phenyl-4-oxo-4H-1-benzopyran pubchem.compound:3973 2-Morpholin-4-yl-8-phenyl-chromen-4-one pubchem.compound:3973 2-MORPHOLIN-4-YL-7-PHENYL-4H-CHROMEN-4-ONE pubchem.compound:3973 2-(morpholin-4-yl)-8-phenylchromen-4-one pubchem.compound:3973 2-(morpholin-4-yl)-8-phenyl-4H-chromen-4-one pubchem.compound:3973 2-(4-morpholino)-8-phenyl-4H-1-benzopyran-4-one pubchem.compound:3973 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one pubchem.compound:3973 1yi3 pubchem.compound:3973 15447-36-6 pubchem.compound:3973 154447-36-6 pubchem.compound:3973 R4 ? MTBR R4 ? R3 ? MTBR R3 ? R2 ? MTBR R2 ? R1 ? MTBR R1 ? MTBR ?