LOCUS NC_002549 18959 bp cRNA linear VRL 13-AUG-2018 DEFINITION Zaire ebolavirus isolate Ebola virus/H.sapiens-tc/COD/1976/Yambuku-Mayinga, complete genome. ACCESSION NC_002549 VERSION NC_002549.1 DBLINK BioProject: PRJNA485481 KEYWORDS RefSeq. SOURCE Zaire ebolavirus ORGANISM Zaire ebolavirus Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; Monjiviricetes; Mononegavirales; Filoviridae; Ebolavirus. REFERENCE 1 (bases 1 to 18959) AUTHORS Volchkov,V.E., Volchkova,V.A., Chepurnov,A.A., Blinov,V.M., Dolnik,O., Netesov,S.V. and Feldmann,H. TITLE Characterization of the L gene and 5' trailer region of Ebola virus JOURNAL J Gen Virol 80 (Pt 2), 355-362 (1999) PUBMED 10073695 REFERENCE 2 (bases 1 to 18959) AUTHORS Volchkov,V.E., Volchkova,V.A., Slenczka,W., Klenk,H.D. and Feldmann,H. TITLE Release of viral glycoproteins during Ebola virus infection JOURNAL Virology 245 (1), 110-119 (1998) PUBMED 9614872 REFERENCE 3 (bases 1 to 18959) AUTHORS Volchkov,V.E., Feldmann,H., Volchkova,V.A. and Klenk,H.D. TITLE Processing of the Ebola virus glycoprotein by the proprotein convertase furin JOURNAL Proc Natl Acad Sci U S A 95 (10), 5762-5767 (1998) PUBMED 9576958 REFERENCE 4 (bases 1 to 18959) AUTHORS Volchkov,V.E., Becker,S., Volchkova,V.A., Ternovoj,V.A., Kotov,A.N., Netesov,S.V. and Klenk,H.D. TITLE GP mRNA of Ebola virus is edited by the Ebola virus polymerase and by T7 and vaccinia virus polymerases JOURNAL Virology 214 (2), 421-430 (1995) PUBMED 8553543 REFERENCE 5 (bases 1 to 18959) AUTHORS Bukreyev,A.A., Volchkov,V.E., Blinov,V.M. and Netesov,S.V. TITLE The VP35 and VP40 proteins of filoviruses. Homology between Marburg and Ebola viruses JOURNAL FEBS Lett 322 (1), 41-46 (1993) PUBMED 8482365 REFERENCE 6 (bases 1 to 18959) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (27-SEP-2000) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 7 (bases 1 to 18959) AUTHORS Volchkov,V.E. TITLE Direct Submission JOURNAL Submitted (02-JUN-2000) Institute of Virology, Philipps-University Marburg, Robert-Koch-Str. 17, Marburg 35037, Germany REMARK Sequence update by submitter REFERENCE 8 (bases 1 to 18959) AUTHORS Volchkov,V.E. TITLE Direct Submission JOURNAL Submitted (20-AUG-1998) Institute of Virology, Philipps-University Marburg, Robert-Koch-Str. 17, Marburg 35037, Germany COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence is identical to AF086833. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..18959 /organism="Zaire ebolavirus" /mol_type="viral cRNA" /isolate="Ebola virus/H.sapiens-tc/COD/1976/Yambuku-Mayinga" /db_xref="taxon:186538" 5'UTR 1..55 /note="leader region" /citation=[1] /function="regulation or initiation of RNA replication" gene 56..3026 /gene="NP" /locus_tag="ZEBOVgp1" /db_xref="GeneID:911830" mRNA 56..3026 /gene="NP" /locus_tag="ZEBOVgp1" /product="nucleoprotein" /db_xref="GeneID:911830" regulatory 56..67 /regulatory_class="other" /gene="NP" /locus_tag="ZEBOVgp1" /note="putative; transcription start signal" /citation=[1] CDS 470..2689 /gene="NP" /locus_tag="ZEBOVgp1" /function="encapsidation of genomic RNA" /codon_start=1 /product="nucleoprotein" /protein_id="NP_066243.1" /db_xref="GeneID:911830" /translation="MDSRPQKIWMAPSLTESDMDYHKILTAGLSVQQGIVRQRVIPVY QVNNLEEICQLIIQAFEAGVDFQESADSFLLMLCLHHAYQGDYKLFLESGAVKYLEGH GFRFEVKKRDGVKRLEELLPAVSSGKNIKRTLAAMPEEETTEANAGQFLSFASLFLPK LVVGEKACLEKVQRQIQVHAEQGLIQYPTAWQSVGHMMVIFRLMRTNFLIKFLLIHQG MHMVAGHDANDAVISNSVAQARFSGLLIVKTVLDHILQKTERGVRLHPLARTAKVKNE VNSFKAALSSLAKHGEYAPFARLLNLSGVNNLEHGLFPQLSAIALGVATAHGSTLAGV NVGEQYQQLREAATEAEKQLQQYAESRELDHLGLDDQEKKILMNFHQKKNEISFQQTN AMVTLRKERLAKLTEAITAASLPKTSGHYDDDDDIPFPGPINDDDNPGHQDDDPTDSQ DTTIPDVVVDPDDGSYGEYQSYSENGMNAPDDLVLFDLDEDDEDTKPVPNRSTKGGQQ KNSQKGQHIEGRQTQSRPIQNVPGPHRTIHHASAPLTDNDRRNEPSGSTSPRMLTPIN EEADPLDDADDETSSLPPLESDDEEQDRDGTSNRTPTVAPPAPVYRDHSEKKELPQDE QQDQDHTQEARNQDSDNTQSEHSFEEMYRHILRSQGPFDAVLYYHMMKDEPVVFSTSD GKEYTYPDSLEEEYPPWLTEKEAMNEENRFVTLDGQQFYWPVMNHKNKFMAILQHHQ" regulatory 3015..3026 /regulatory_class="polyA_signal_sequence" /gene="NP" /locus_tag="ZEBOVgp1" misc_feature 3027..3031 /note="intergenic region" gene 3032..4407 /gene="VP35" /locus_tag="ZEBOVgp2" /db_xref="GeneID:911827" mRNA 3032..4407 /gene="VP35" /locus_tag="ZEBOVgp2" /product="VP35" /citation=[5] /db_xref="GeneID:911827" regulatory 3032..3043 /regulatory_class="other" /gene="VP35" /locus_tag="ZEBOVgp2" /note="putative; transcription start signal" /citation=[5] CDS 3129..4151 /gene="VP35" /locus_tag="ZEBOVgp2" /function="RNA-dependent RNA polymerase cofactor" /citation=[5] /codon_start=1 /product="polymerase complex protein" /protein_id="NP_066244.1" /db_xref="GeneID:911827" /translation="MTTRTKGRGHTAATTQNDRMPGPELSGWISEQLMTGRIPVSDIF CDIENNPGLCYASQMQQTKPNPKTRNSQTQTDPICNHSFEEVVQTLASLATVVQQQTI ASESLEQRITSLENGLKPVYDMAKTISSLNRVCAEMVAKYDLLVMTTGRATATAAATE AYWAEHGQPPPGPSLYEESAIRGKIESRDETVPQSVREAFNNLNSTTSLTEENFGKPD ISAKDLRNIMYDHLPGFGTAFHQLVQVICKLGKDSNSLDIIHAEFQASLAEGDSPQCA LIQITKRVPIFQDAAPPVIHIRSRGDIPRACQKSLRPVPPSPKIDRGWVCVFQLQDGK TLGLKI" gene 4390..5894 /gene="VP40" /locus_tag="ZEBOVgp3" /db_xref="GeneID:911825" mRNA 4390..5894 /gene="VP40" /locus_tag="ZEBOVgp3" /product="VP40" /citation=[5] /db_xref="GeneID:911825" regulatory 4390..4401 /regulatory_class="other" /gene="VP40" /locus_tag="ZEBOVgp3" /note="transcription start signal" /citation=[5] regulatory 4397..4407 /regulatory_class="polyA_signal_sequence" /gene="VP35" /locus_tag="ZEBOVgp2" /citation=[5] CDS 4479..5459 /gene="VP40" /locus_tag="ZEBOVgp3" /note="coalesce nucleocapsids and cell membranes in virion assembly (budding)" /citation=[5] /codon_start=1 /product="matrix protein" /protein_id="NP_066245.1" /db_xref="GeneID:911825" /translation="MRRVILPTAPPEYMEAIYPVRSNSTIARGGNSNTGFLTPESVNG DTPSNPLRPIADDTIDHASHTPGSVSSAFILEAMVNVISGPKVLMKQIPIWLPLGVAD QKTYSFDSTTAAIMLASYTITHFGKATNPLVRVNRLGPGIPDHPLRLLRIGNQAFLQE FVLPPVQLPQYFTFDLTALKLITQPLPAATWTDDTPTGSNGALRPGISFHPKLRPILL PNKSGKKGNSADLTSPEKIQAIMTSLQDFKIVPIDPTKNIMGIEVPETLVHKLTGKKV TSKNGQPIIPVLLPKYIGLDPVAPGDLTMVITQDCDTCHSPASLPAVIEK" regulatory 5883..5894 /regulatory_class="polyA_signal_sequence" /gene="VP40" /locus_tag="ZEBOVgp3" /citation=[5] misc_feature 5895..5899 /note="intergenic region" gene 5900..8305 /gene="GP" /locus_tag="ZEBOVgp4" /db_xref="GeneID:911829" mRNA 5900..8305 /gene="GP" /locus_tag="ZEBOVgp4" /product="sGP" /note="unedited mRNA" /citation=[4] /db_xref="GeneID:911829" regulatory 5900..5911 /regulatory_class="other" /gene="GP" /locus_tag="ZEBOVgp4" /note="putative; transcription start signal" /citation=[4] CDS join(6039..6923,6923..8068) /gene="GP" /locus_tag="ZEBOVgp4" /function="receptor binding and fusion" /exception="RNA editing" /note="virion spike glycoprotein precursor; an additional A residue is inserted during transcription; encodes two disulfide linked subunits GP1 and GP2" /citation=[2] /citation=[3] /citation=[4] /codon_start=1 /product="spike glycoprotein" /protein_id="NP_066246.1" /db_xref="GeneID:911829" /translation="MGVTGILQLPRDRFKRTSFFLWVIILFQRTFSIPLGVIHNSTLQ VSDVDKLVCRDKLSSTNQLRSVGLNLEGNGVATDVPSATKRWGFRSGVPPKVVNYEAG EWAENCYNLEIKKPDGSECLPAAPDGIRGFPRCRYVHKVSGTGPCAGDFAFHKEGAFF LYDRLASTVIYRGTTFAEGVVAFLILPQAKKDFFSSHPLREPVNATEDPSSGYYSTTI RYQATGFGTNETEYLFEVDNLTYVQLESRFTPQFLLQLNETIYTSGKRSNTTGKLIWK VNPEIDTTIGEWAFWETKKNLTRKIRSEELSFTVVSNGAKNISGQSPARTSSDPGTNT TTEDHKIMASENSSAMVQVHSQGREAAVSHLTTLATISTSPQSLTTKPGPDNSTHNTP VYKLDISEATQVEQHHRRTDNDSTASDTPSATTAAGPPKAENTNTSKSTDFLDPATTT SPQNHSETAGNNNTHHQDTGEESASSGKLGLITNTIAGVAGLITGGRRTRREAIVNAQ PKCNPNLHYWTTQDEGAAIGLAWIPYFGPAAEGIYIEGLMHNQDGLICGLRQLANETT QALQLFLRATTELRTFSILNRKAIDFLLQRWGGTCHILGPDCCIEPHDWTKNITDKID QIIHDFVDKTLPDQGDNDNWWTGWRQWIPAGIGVTGVIIAVIALFCICKFVF" misc_feature 7529..7540 /gene="GP" /locus_tag="ZEBOVgp4" /note="encodes the glycoprotein cleavage site, precursor GP is cleaved by subtilisin-like cellular protease furin into subunits GP1 and GP2 that are linked by a disulfide bond" /citation=[3] misc_feature 7793..7870 /gene="GP" /locus_tag="ZEBOVgp4" /note="immunosuppressive motif; other site" misc_feature 7988..8053 /gene="GP" /locus_tag="ZEBOVgp4" /note="transmembrane anchor; transmembrane region" CDS 6039..7133 /gene="GP" /locus_tag="ZEBOVgp4" /note="small non-structural secreted glycoprotein; sGP; sGP, small non-structural, secreted glycoprotein; sGP secreted as an anti-parallel oriented homodimer" /citation=[4] /codon_start=1 /product="small secreted glycoprotein" /protein_id="NP_066247.1" /db_xref="GeneID:911829" /translation="MGVTGILQLPRDRFKRTSFFLWVIILFQRTFSIPLGVIHNSTLQ VSDVDKLVCRDKLSSTNQLRSVGLNLEGNGVATDVPSATKRWGFRSGVPPKVVNYEAG EWAENCYNLEIKKPDGSECLPAAPDGIRGFPRCRYVHKVSGTGPCAGDFAFHKEGAFF LYDRLASTVIYRGTTFAEGVVAFLILPQAKKDFFSSHPLREPVNATEDPSSGYYSTTI RYQATGFGTNETEYLFEVDNLTYVQLESRFTPQFLLQLNETIYTSGKRSNTTGKLIWK VNPEIDTTIGEWAFWETKKTSLEKFAVKSCLSQLYQTEPKTSVVRVRRELLPTQGPTQ QLKTTKSWLQKIPLQWFKCTVKEGKLQCRI" CDS join(6039..6922,6924..6933) /gene="GP" /locus_tag="ZEBOVgp4" /exception="RNA editing" /note="ssGP; second non-structural secreted glycoprotein; super small secreted glycoprotein; secreted in a monomeric form; one A residue is deleted or two additional A residues are inserted at the editing site during transcription of the GP gene" /citation=[4] /codon_start=1 /product="second secreted glycoprotein" /protein_id="NP_066248.1" /db_xref="GeneID:911829" /translation="MGVTGILQLPRDRFKRTSFFLWVIILFQRTFSIPLGVIHNSTLQ VSDVDKLVCRDKLSSTNQLRSVGLNLEGNGVATDVPSATKRWGFRSGVPPKVVNYEAG EWAENCYNLEIKKPDGSECLPAAPDGIRGFPRCRYVHKVSGTGPCAGDFAFHKEGAFF LYDRLASTVIYRGTTFAEGVVAFLILPQAKKDFFSSHPLREPVNATEDPSSGYYSTTI RYQATGFGTNETEYLFEVDNLTYVQLESRFTPQFLLQLNETIYTSGKRSNTTGKLIWK VNPEIDTTIGEWAFWETKKPH" regulatory 6918..6924 /regulatory_class="other" /gene="GP" /locus_tag="ZEBOVgp4" /note="additional A residues are inserted or deleted during transcription of the GP gene by the viral polymerase" /citation=[4] /function="RNA editing" gene 8288..9740 /gene="VP30" /locus_tag="ZEBOVgp5" /db_xref="GeneID:911826" mRNA 8288..9740 /gene="VP30" /locus_tag="ZEBOVgp5" /product="VP30" /db_xref="GeneID:911826" regulatory 8288..8299 /regulatory_class="other" /gene="VP30" /locus_tag="ZEBOVgp5" /note="putative; transcription start signal" regulatory 8295..8305 /regulatory_class="polyA_signal_sequence" /gene="GP" /locus_tag="ZEBOVgp4" /citation=[4] CDS 8509..9375 /gene="VP30" /locus_tag="ZEBOVgp5" /function="encapsidation of genomic RNA" /note="polymerase complex protein" /codon_start=1 /product="minor nucleoprotein" /protein_id="NP_066249.1" /db_xref="GeneID:911826" /translation="MEASYERGRPRAARQHSRDGHDHHVRARSSSRENYRGEYRQSRS ASQVRVPTVFHKKRVEPLTVPPAPKDICPTLKKGFLCDSSFCKKDHQLESLTDRELLL LIARKTCGSVEQQLNITAPKDSRLANPTADDFQQEEGPKITLLTLIKTAEHWARQDIR TIEDSKLRALLTLCAVMTRKFSKSQLSLLCETHLRREGLGQDQAEPVLEVYQRLHSDK GGSFEAALWQQWDRQSLIMFITAFLNIALQLPCESSAVVVSGLRTLVPQSDNEEASTN PGTCSWSDEGTP" regulatory 9730..9740 /regulatory_class="polyA_signal_sequence" /gene="VP30" /locus_tag="ZEBOVgp5" /note="putative" misc_feature 9741..9884 /note="intergenic region" gene 9885..11518 /gene="VP24" /locus_tag="ZEBOVgp6" /note="putative" /db_xref="GeneID:911828" mRNA 9885..11496 /gene="VP24" /locus_tag="ZEBOVgp6" /product="VP24" /db_xref="GeneID:911828" regulatory 9885..9896 /regulatory_class="other" /gene="VP24" /locus_tag="ZEBOVgp6" /note="transcription start signal" CDS 10345..11100 /gene="VP24" /locus_tag="ZEBOVgp6" /codon_start=1 /product="membrane-associated protein" /protein_id="NP_066250.1" /db_xref="GeneID:911828" /translation="MAKATGRYNLISPKKDLEKGVVLSDLCNFLVSQTIQGWKVYWAG IEFDVTHKGMALLHRLKTNDFAPAWSMTRNLFPHLFQNPNSTIESPLWALRVILAAGI QDQLIDQSLIEPLAGALGLISDWLLTTNTNHFNMRTQRVKEQLSLKMLSLIRSNILKF INKLDALHVVNYNGLLSSIEIGTQNHTIIITRTNMGFLVELQEPDKSAMNRMKPGPAK FSLLHESTLKAFTQGSSTRMQSLILEFNSSLAI" regulatory 11485..11496 /regulatory_class="polyA_signal_sequence" /gene="VP24" /locus_tag="ZEBOVgp6" /note="putative" misc_feature 11497..11500 /gene="VP24" /locus_tag="ZEBOVgp6" /note="intergenic region" gene 11501..18282 /gene="L" /locus_tag="ZEBOVgp7" /db_xref="GeneID:911824" mRNA 11501..18282 /gene="L" /locus_tag="ZEBOVgp7" /product="polymerase" /citation=[1] /db_xref="GeneID:911824" regulatory 11501..11512 /regulatory_class="other" /gene="L" /locus_tag="ZEBOVgp7" /note="transcription start signal" /citation=[1] regulatory 11508..11518 /regulatory_class="polyA_signal_sequence" /gene="VP24" /locus_tag="ZEBOVgp6" CDS 11581..18219 /gene="L" /locus_tag="ZEBOVgp7" /function="synthesis of viral RNAs; transcriptional RNA editing" /citation=[1] /codon_start=1 /product="RNA-dependent RNA polymerase" /protein_id="NP_066251.1" /db_xref="GeneID:911824" /translation="MATQHTQYPDARLSSPIVLDQCDLVTRACGLYSSYSLNPQLRNC KLPKHIYRLKYDVTVTKFLSDVPVATLPIDFIVPVLLKALSGNGFCPVEPRCQQFLDE IIKYTMQDALFLKYYLKNVGAQEDCVDEHFQEKILSSIQGNEFLHQMFFWYDLAILTR RGRLNRGNSRSTWFVHDDLIDILGYGDYVFWKIPISMLPLNTQGIPHAAMDWYQASVF KEAVQGHTHIVSVSTADVLIMCKDLITCRFNTTLISKIAEIEDPVCSDYPNFKIVSML YQSGDYLLSILGSDGYKIIKFLEPLCLAKIQLCSKYTERKGRFLTQMHLAVNHTLEEI TEMRALKPSQAQKIREFHRTLIRLEMTPQQLCELFSIQKHWGHPVLHSETAIQKVKKH ATVLKALRPIVIFETYCVFKYSIAKHYFDSQGSWYSVTSDRNLTPGLNSYIKRNQFPP LPMIKELLWEFYHLDHPPLFSTKIISDLSIFIKDRATAVERTCWDAVFEPNVLGYNPP HKFSTKRVPEQFLEQENFSIENVLSYAQKLEYLLPQYRNFSFSLKEKELNVGRTFGKL PYPTRNVQTLCEALLADGLAKAFPSNMMVVTEREQKESLLHQASWHHTSDDFGEHATV RGSSFVTDLEKYNLAFRYEFTAPFIEYCNRCYGVKNVFNWMHYTIPQCYMHVSDYYNP PHNLTLENRDNPPEGPSSYRGHMGGIEGLQQKLWTSISCAQISLVEIKTGFKLRSAVM GDNQCITVLSVFPLETDADEQEQSAEDNAARVAASLAKVTSACGIFLKPDETFVHSGF IYFGKKQYLNGVQLPQSLKTATRMAPLSDAIFDDLQGTLASIGTAFERSISETRHIFP CRITAAFHTFFSVRILQYHHLGFNKGFDLGQLTLGKPLDFGTISLALAVPQVLGGLSF LNPEKCFYRNLGDPVTSGLFQLKTYLRMIEMDDLFLPLIAKNPGNCTAIDFVLNPSGL NVPGSQDLTSFLRQIVRRTITLSAKNKLINTLFHASADFEDEMVCKWLLSSTPVMSRF AADIFSRTPSGKRLQILGYLEGTRTLLASKIINNNTETPVLDRLRKITLQRWSLWFSY LDHCDNILAEALTQITCTVDLAQILREYSWAHILEGRPLIGATLPCMIEQFKVFWLKP YEQCPQCSNAKQPGGKPFVSVAVKKHIVSAWPNASRISWTIGDGIPYIGSRTEDKIGQ PAIKPKCPSAALREAIELASRLTWVTQGSSNSDLLIKPFLEARVNLSVQEILQMTPSH YSGNIVHRYNDQYSPHSFMANRMSNSATRLIVSTNTLGEFSGGGQSARDSNIIFQNVI NYAVALFDIKFRNTEATDIQYNRAHLHLTKCCTREVPAQYLTYTSTLDLDLTRYRENE LIYDSNPLKGGLNCNISFDNPFFQGKRLNIIEDDLIRLPHLSGWELAKTIMQSIISDS NNSSTDPISSGETRSFTTHFLTYPKIGLLYSFGAFVSYYLGNTILRTKKLTLDNFLYY LTTQIHNLPHRSLRILKPTFKHASVMSRLMSIDPHFSIYIGGAAGDRGLSDAARLFLR TSISSFLTFVKEWIINRGTIVPLWIVYPLEGQNPTPVNNFLYQIVELLVHDSSRQQAF KTTISDHVHPHDNLVYTCKSTASNFFHASLAYWRSRHRNSNRKYLARDSSTGSSTNNS DGHIERSQEQTTRDPHDGTERNLVLQMSHEIKRTTIPQENTHQGPSFQSFLSDSACGT ANPKLNFDRSRHNVKFQDHNSASKREGHQIISHRLVLPFFTLSQGTRQLTSSNESQTQ DEISKYLRQLRSVIDTTVYCRFTGIVSSMHYKLDEVLWEIESFKSAVTLAEGEGAGAL LLIQKYQVKTLFFNTLATESSIESEIVSGMTTPRMLLPVMSKFHNDQIEIILNNSASQ ITDITNPTWFKDQRARLPKQVEVITMDAETTENINRSKLYEAVYKLILHHIDPSVLKA VVLKVFLSDTEGMLWLNDNLAPFFATGYLIKPITSSARSSEWYLCLTNFLSTTRKMPH QNHLSCKQVILTALQLQIQRSPYWLSHLTQYADCELHLSYIRLGFPSLEKVLYHRYNL VDSKRGPLVSITQHLAHLRAEIRELTNDYNQQRQSRTQTYHFIRTAKGRITKLVNDYL KFFLIVQALKHNGTWQAEFKKLPELISVCNRFYHIRDCNCEERFLVQTLYLHRMQDSE VKLIERLTGLLSLFPDGLYRFD" regulatory 18272..18282 /regulatory_class="polyA_signal_sequence" /gene="L" /locus_tag="ZEBOVgp7" /citation=[1] 3'UTR 18283..18959 /note="trailer region" /citation=[1] /function="regulation or initiation of RNA replication" ORIGIN 1 cggacacaca aaaagaaaga agaattttta ggatcttttg tgtgcgaata actatgagga 61 agattaataa ttttcctctc attgaaattt atatcggaat ttaaattgaa attgttactg 121 taatcacacc tggtttgttt cagagccaca tcacaaagat agagaacaac ctaggtctcc 181 gaagggagca agggcatcag tgtgctcagt tgaaaatccc ttgtcaacac ctaggtctta 241 tcacatcaca agttccacct cagactctgc agggtgatcc aacaacctta atagaaacat 301 tattgttaaa ggacagcatt agttcacagt caaacaagca agattgagaa ttaaccttgg 361 ttttgaactt gaacacttag gggattgaag attcaacaac cctaaagctt ggggtaaaac 421 attggaaata gttaaaagac aaattgctcg gaatcacaaa attccgagta tggattctcg 481 tcctcagaaa atctggatgg cgccgagtct cactgaatct gacatggatt accacaagat 541 cttgacagca ggtctgtccg ttcaacaggg gattgttcgg caaagagtca tcccagtgta 601 tcaagtaaac aatcttgaag aaatttgcca acttatcata caggcctttg aagcaggtgt 661 tgattttcaa gagagtgcgg acagtttcct tctcatgctt tgtcttcatc atgcgtacca 721 gggagattac aaacttttct tggaaagtgg cgcagtcaag tatttggaag ggcacgggtt 781 ccgttttgaa gtcaagaagc gtgatggagt gaagcgcctt gaggaattgc tgccagcagt 841 atctagtgga aaaaacatta agagaacact tgctgccatg ccggaagagg agacaactga 901 agctaatgcc ggtcagtttc tctcctttgc aagtctattc cttccgaaat tggtagtagg 961 agaaaaggct tgccttgaga aggttcaaag gcaaattcaa gtacatgcag agcaaggact 1021 gatacaatat ccaacagctt ggcaatcagt aggacacatg atggtgattt tccgtttgat 1081 gcgaacaaat tttctgatca aatttctcct aatacaccaa gggatgcaca tggttgccgg 1141 gcatgatgcc aacgatgctg tgatttcaaa ttcagtggct caagctcgtt tttcaggctt 1201 attgattgtc aaaacagtac ttgatcatat cctacaaaag acagaacgag gagttcgtct 1261 ccatcctctt gcaaggaccg ccaaggtaaa aaatgaggtg aactccttta aggctgcact 1321 cagctccctg gccaagcatg gagagtatgc tcctttcgcc cgacttttga acctttctgg 1381 agtaaataat cttgagcatg gtcttttccc tcaactatcg gcaattgcac tcggagtcgc 1441 cacagcacac gggagtaccc tcgcaggagt aaatgttgga gaacagtatc aacaactcag 1501 agaggctgcc actgaggctg agaagcaact ccaacaatat gcagagtctc gcgaacttga 1561 ccatcttgga cttgatgatc aggaaaagaa aattcttatg aacttccatc agaaaaagaa 1621 cgaaatcagc ttccagcaaa caaacgctat ggtaactcta agaaaagagc gcctggccaa 1681 gctgacagaa gctatcactg ctgcgtcact gcccaaaaca agtggacatt acgatgatga 1741 tgacgacatt ccctttccag gacccatcaa tgatgacgac aatcctggcc atcaagatga 1801 tgatccgact gactcacagg atacgaccat tcccgatgtg gtggttgatc ccgatgatgg 1861 aagctacggc gaataccaga gttactcgga aaacggcatg aatgcaccag atgacttggt 1921 cctattcgat ctagacgagg acgacgagga cactaagcca gtgcctaata gatcgaccaa 1981 gggtggacaa cagaagaaca gtcaaaaggg ccagcatata gagggcagac agacacaatc 2041 caggccaatt caaaatgtcc caggccctca cagaacaatc caccacgcca gtgcgccact 2101 cacggacaat gacagaagaa atgaaccctc cggctcaacc agccctcgca tgctgacacc 2161 aattaacgaa gaggcagacc cactggacga tgccgacgac gagacgtcta gccttccgcc 2221 cttggagtca gatgatgaag agcaggacag ggacggaact tccaaccgca cacccactgt 2281 cgccccaccg gctcccgtat acagagatca ctctgaaaag aaagaactcc cgcaagacga 2341 gcaacaagat caggaccaca ctcaagaggc caggaaccag gacagtgaca acacccagtc 2401 agaacactct tttgaggaga tgtatcgcca cattctaaga tcacaggggc catttgatgc 2461 tgttttgtat tatcatatga tgaaggatga gcctgtagtt ttcagtacca gtgatggcaa 2521 agagtacacg tatccagact cccttgaaga ggaatatcca ccatggctca ctgaaaaaga 2581 ggctatgaat gaagagaata gatttgttac attggatggt caacaatttt attggccggt 2641 gatgaatcac aagaataaat tcatggcaat cctgcaacat catcagtgaa tgagcatgga 2701 acaatgggat gattcaaccg acaaatagct aacattaagt agtcaaggaa cgaaaacagg 2761 aagaattttt gatgtctaag gtgtgaatta ttatcacaat aaaagtgatt cttatttttg 2821 aatttaaagc tagcttatta ttactagccg tttttcaaag ttcaatttga gtcttaatgc 2881 aaataggcgt taagccacag ttatagccat aattgtaact caatattcta actagcgatt 2941 tatctaaatt aaattacatt atgcttttat aacttaccta ctagcctgcc caacatttac 3001 acgatcgttt tataattaag aaaaaactaa tgatgaagat taaaaccttc atcatcctta 3061 cgtcaattga attctctagc actcgaagct tattgtcttc aatgtaaaag aaaagctggt 3121 ctaacaagat gacaactaga acaaagggca ggggccatac tgcggccacg actcaaaacg 3181 acagaatgcc aggccctgag ctttcgggct ggatctctga gcagctaatg accggaagaa 3241 ttcctgtaag cgacatcttc tgtgatattg agaacaatcc aggattatgc tacgcatccc 3301 aaatgcaaca aacgaagcca aacccgaaga cgcgcaacag tcaaacccaa acggacccaa 3361 tttgcaatca tagttttgag gaggtagtac aaacattggc ttcattggct actgttgtgc 3421 aacaacaaac catcgcatca gaatcattag aacaacgcat tacgagtctt gagaatggtc 3481 taaagccagt ttatgatatg gcaaaaacaa tctcctcatt gaacagggtt tgtgctgaga 3541 tggttgcaaa atatgatctt ctggtgatga caaccggtcg ggcaacagca accgctgcgg 3601 caactgaggc ttattgggcc gaacatggtc aaccaccacc tggaccatca ctttatgaag 3661 aaagtgcgat tcggggtaag attgaatcta gagatgagac cgtccctcaa agtgttaggg 3721 aggcattcaa caatctaaac agtaccactt cactaactga ggaaaatttt gggaaacctg 3781 acatttcggc aaaggatttg agaaacatta tgtatgatca cttgcctggt tttggaactg 3841 ctttccacca attagtacaa gtgatttgta aattgggaaa agatagcaac tcattggaca 3901 tcattcatgc tgagttccag gccagcctgg ctgaaggaga ctctcctcaa tgtgccctaa 3961 ttcaaattac aaaaagagtt ccaatcttcc aagatgctgc tccacctgtc atccacatcc 4021 gctctcgagg tgacattccc cgagcttgcc agaaaagctt gcgtccagtc ccaccatcgc 4081 ccaagattga tcgaggttgg gtatgtgttt ttcagcttca agatggtaaa acacttggac 4141 tcaaaatttg agccaatctc ccttccctcc gaaagaggcg aataatagca gaggcttcaa 4201 ctgctgaact atagggtacg ttacattaat gatacacttg tgagtatcag ccctggataa 4261 tataagtcaa ttaaacgacc aagataaaat tgttcatatc tcgctagcag cttaaaatat 4321 aaatgtaata ggagctatat ctctgacagt attataatca attgttatta agtaacccaa 4381 accaaaagtg atgaagatta agaaaaacct acctcggctg agagagtgtt ttttcattaa 4441 ccttcatctt gtaaacgttg agcaaaattg ttaaaaatat gaggcgggtt atattgccta 4501 ctgctcctcc tgaatatatg gaggccatat accctgtcag gtcaaattca acaattgcta 4561 gaggtggcaa cagcaataca ggcttcctga caccggagtc agtcaatggg gacactccat 4621 cgaatccact caggccaatt gccgatgaca ccatcgacca tgccagccac acaccaggca 4681 gtgtgtcatc agcattcatc cttgaagcta tggtgaatgt catatcgggc cccaaagtgc 4741 taatgaagca aattccaatt tggcttcctc taggtgtcgc tgatcaaaag acctacagct 4801 ttgactcaac tacggccgcc atcatgcttg cttcatacac tatcacccat ttcggcaagg 4861 caaccaatcc acttgtcaga gtcaatcggc tgggtcctgg aatcccggat catcccctca 4921 ggctcctgcg aattggaaac caggctttcc tccaggagtt cgttcttccg ccagtccaac 4981 taccccagta tttcaccttt gatttgacag cactcaaact gatcacccaa ccactgcctg 5041 ctgcaacatg gaccgatgac actccaacag gatcaaatgg agcgttgcgt ccaggaattt 5101 catttcatcc aaaacttcgc cccattcttt tacccaacaa aagtgggaag aaggggaaca 5161 gtgccgatct aacatctccg gagaaaatcc aagcaataat gacttcactc caggacttta 5221 agatcgttcc aattgatcca accaaaaata tcatgggaat cgaagtgcca gaaactctgg 5281 tccacaagct gaccggtaag aaggtgactt ctaaaaatgg acaaccaatc atccctgttc 5341 ttttgccaaa gtacattggg ttggacccgg tggctccagg agacctcacc atggtaatca 5401 cacaggattg tgacacgtgt cattctcctg caagtcttcc agctgtgatt gagaagtaat 5461 tgcaataatt gactcagatc cagttttata gaatcttctc agggatagtg ataacatcta 5521 tttagtaatc cgtccattag aggagacact tttaattgat caatatacta aaggtgcttt 5581 acaccattgt cttttttctc tcctaaatgt agaacttaac aaaagactca taatatactt 5641 gtttttaaag gattgattga tgaaagatca taactaataa cattacaaat aatcctacta 5701 taatcaatac ggtgattcaa atgttaatct ttctcattgc acatactttt tgcccttatc 5761 ctcaaattgc ctgcatgctt acatctgagg atagccagtg tgacttggat tggaaatgtg 5821 gagaaaaaat cgggacccat ttctaggttg ttcacaatcc aagtacagac attgcccttc 5881 taattaagaa aaaatcggcg atgaagatta agccgacagt gagcgtaatc ttcatctctc 5941 ttagattatt tgttttccag agtaggggtc gtcaggtcct tttcaatcgt gtaaccaaaa 6001 taaactccac tagaaggata ttgtggggca acaacacaat gggcgttaca ggaatattgc 6061 agttacctcg tgatcgattc aagaggacat cattctttct ttgggtaatt atccttttcc 6121 aaagaacatt ttccatccca cttggagtca tccacaatag cacattacag gttagtgatg 6181 tcgacaaact agtttgtcgt gacaaactgt catccacaaa tcaattgaga tcagttggac 6241 tgaatctcga agggaatgga gtggcaactg acgtgccatc tgcaactaaa agatggggct 6301 tcaggtccgg tgtcccacca aaggtggtca attatgaagc tggtgaatgg gctgaaaact 6361 gctacaatct tgaaatcaaa aaacctgacg ggagtgagtg tctaccagca gcgccagacg 6421 ggattcgggg cttcccccgg tgccggtatg tgcacaaagt atcaggaacg ggaccgtgtg 6481 ccggagactt tgccttccat aaagagggtg ctttcttcct gtatgatcga cttgcttcca 6541 cagttatcta ccgaggaacg actttcgctg aaggtgtcgt tgcatttctg atactgcccc 6601 aagctaagaa ggacttcttc agctcacacc ccttgagaga gccggtcaat gcaacggagg 6661 acccgtctag tggctactat tctaccacaa ttagatatca ggctaccggt tttggaacca 6721 atgagacaga gtacttgttc gaggttgaca atttgaccta cgtccaactt gaatcaagat 6781 tcacaccaca gtttctgctc cagctgaatg agacaatata tacaagtggg aaaaggagca 6841 ataccacggg aaaactaatt tggaaggtca accccgaaat tgatacaaca atcggggagt 6901 gggccttctg ggaaactaaa aaaacctcac tagaaaaatt cgcagtgaag agttgtcttt 6961 cacagttgta tcaaacggag ccaaaaacat cagtggtcag agtccggcgc gaacttcttc 7021 cgacccaggg accaacacaa caactgaaga ccacaaaatc atggcttcag aaaattcctc 7081 tgcaatggtt caagtgcaca gtcaaggaag ggaagctgca gtgtcgcatc taacaaccct 7141 tgccacaatc tccacgagtc cccaatccct cacaaccaaa ccaggtccgg acaacagcac 7201 ccataataca cccgtgtata aacttgacat ctctgaggca actcaagttg aacaacatca 7261 ccgcagaaca gacaacgaca gcacagcctc cgacactccc tctgccacga ccgcagccgg 7321 acccccaaaa gcagagaaca ccaacacgag caagagcact gacttcctgg accccgccac 7381 cacaacaagt ccccaaaacc acagcgagac cgctggcaac aacaacactc atcaccaaga 7441 taccggagaa gagagtgcca gcagcgggaa gctaggctta attaccaata ctattgctgg 7501 agtcgcagga ctgatcacag gcgggagaag aactcgaaga gaagcaattg tcaatgctca 7561 acccaaatgc aaccctaatt tacattactg gactactcag gatgaaggtg ctgcaatcgg 7621 actggcctgg ataccatatt tcgggccagc agccgaggga atttacatag aggggctaat 7681 gcacaatcaa gatggtttaa tctgtgggtt gagacagctg gccaacgaga cgactcaagc 7741 tcttcaactg ttcctgagag ccacaactga gctacgcacc ttttcaatcc tcaaccgtaa 7801 ggcaattgat ttcttgctgc agcgatgggg cggcacatgc cacattctgg gaccggactg 7861 ctgtatcgaa ccacatgatt ggaccaagaa cataacagac aaaattgatc agattattca 7921 tgattttgtt gataaaaccc ttccggacca gggggacaat gacaattggt ggacaggatg 7981 gagacaatgg ataccggcag gtattggagt tacaggcgtt ataattgcag ttatcgcttt 8041 attctgtata tgcaaatttg tcttttagtt tttcttcaga ttgcttcatg gaaaagctca 8101 gcctcaaatc aatgaaacca ggatttaatt atatggatta cttgaatcta agattacttg 8161 acaaatgata atataataca ctggagcttt aaacatagcc aatgtgattc taactccttt 8221 aaactcacag ttaatcataa acaaggtttg acatcaatct agttatctct ttgagaatga 8281 taaacttgat gaagattaag aaaaaggtaa tctttcgatt atctttaatc ttcatccttg 8341 attctacaat catgacagtt gtctttagtg acaagggaaa gaagcctttt tattaagttg 8401 taataatcag atctgcgaac cggtagagtt tagttgcaac ctaacacaca taaagcattg 8461 gtcaaaaagt caatagaaat ttaaacagtg agtggagaca acttttaaat ggaagcttca 8521 tatgagagag gacgcccacg agctgccaga cagcattcaa gggatggaca cgaccaccat 8581 gttcgagcac gatcatcatc cagagagaat tatcgaggtg agtaccgtca atcaaggagc 8641 gcctcacaag tgcgcgttcc tactgtattt cataagaaga gagttgaacc attaacagtt 8701 cctccagcac ctaaagacat atgtccgacc ttgaaaaaag gatttttgtg tgacagtagt 8761 ttttgcaaaa aagatcacca gttggagagt ttaactgata gggaattact cctactaatc 8821 gcccgtaaga cttgtggatc agtagaacaa caattaaata taactgcacc caaggactcg 8881 cgcttagcaa atccaacggc tgatgatttc cagcaagagg aaggtccaaa aattaccttg 8941 ttgacactga tcaagacggc agaacactgg gcgagacaag acatcagaac catagaggat 9001 tcaaaattaa gagcattgtt gactctatgt gctgtgatga cgaggaaatt ctcaaaatcc 9061 cagctgagtc ttttatgtga gacacaccta aggcgcgagg ggcttgggca agatcaggca 9121 gaacccgttc tcgaagtata tcaacgatta cacagtgata aaggaggcag ttttgaagct 9181 gcactatggc aacaatggga ccgacaatcc ctaattatgt ttatcactgc attcttgaat 9241 attgctctcc agttaccgtg tgaaagttct gctgtcgttg tttcagggtt aagaacattg 9301 gttcctcaat cagataatga ggaagcttca accaacccgg ggacatgctc atggtctgat 9361 gagggtaccc cttaataagg ctgactaaaa cactatataa ccttctactt gatcacaata 9421 ctccgtatac ctatcatcat atatttaatc aagacgatat cctttaaaac ttattcagta 9481 ctataatcac tctcgtttca aattaataag atgtgcatga ttgccctaat atatgaagag 9541 gtatgataca accctaacag tgatcaaaga aaatcataat ctcgtatcgc tcgtaatata 9601 acctgccaag catacctctt gcacaaagtg attcttgtac acaaataatg ttttactcta 9661 caggaggtag caacgatcca tcccatcaaa aaataagtat ttcatgactt actaatgatc 9721 tcttaaaata ttaagaaaaa ctgacggaac ataaattctt tatgcttcaa gctgtggagg 9781 aggtgtttgg tattggctat tgttatatta caatcaataa caagcttgta aaaatattgt 9841 tcttgtttca agaggtagat tgtgaccgga aatgctaaac taatgatgaa gattaatgcg 9901 gaggtctgat aagaataaac cttattattc agattaggcc ccaagaggca ttcttcatct 9961 ccttttagca aagtactatt tcagggtagt ccaattagtg gcacgtcttt tagctgtata 10021 tcagtcgccc ctgagatacg ccacaaaagt gtctctaagc taaattggtc tgtacacatc 10081 ccatacattg tattaggggc aataatatct aattgaactt agccgtttaa aatttagtgc 10141 ataaatctgg gctaacacca ccaggtcaac tccattggct gaaaagaagc ttacctacaa 10201 cgaacatcac tttgagcgcc ctcacaatta aaaaatagga acgtcgttcc aacaatcgag 10261 cgcaaggttt caaggttgaa ctgagagtgt ctagacaaca aaatattgat actccagaca 10321 ccaagcaaga cctgagaaaa aaccatggct aaagctacgg gacgatacaa tctaatatcg 10381 cccaaaaagg acctggagaa aggggttgtc ttaagcgacc tctgtaactt cttagttagc 10441 caaactattc aggggtggaa ggtttattgg gctggtattg agtttgatgt gactcacaaa 10501 ggaatggccc tattgcatag actgaaaact aatgactttg cccctgcatg gtcaatgaca 10561 aggaatctct ttcctcattt atttcaaaat ccgaattcca caattgaatc accgctgtgg 10621 gcattgagag tcatccttgc agcagggata caggaccagc tgattgacca gtctttgatt 10681 gaacccttag caggagccct tggtctgatc tctgattggc tgctaacaac caacactaac 10741 catttcaaca tgcgaacaca acgtgtcaag gaacaattga gcctaaaaat gctgtcgttg 10801 attcgatcca atattctcaa gtttattaac aaattggatg ctctacatgt cgtgaactac 10861 aacggattgt tgagcagtat tgaaattgga actcaaaatc atacaatcat cataactcga 10921 actaacatgg gttttctggt ggagctccaa gaacccgaca aatcggcaat gaaccgcatg 10981 aagcctgggc cggcgaaatt ttccctcctt catgagtcca cactgaaagc atttacacaa 11041 ggatcctcga cacgaatgca aagtttgatt cttgaattta atagctctct tgctatctaa 11101 ctaaggtaga atacttcata ttgagctaac tcatatatgc tgactcaata gttatcttga 11161 catctctgct ttcataatca gatatataag cataataaat aaatactcat atttcttgat 11221 aatttgttta accacagata aatcctcact gtaagccagc ttccaagttg acacccttac 11281 aaaaaccagg actcagaatc cctcaaacaa gagattccaa gacaacatca tagaattgct 11341 ttattatatg aataagcatt ttatcaccag aaatcctata tactaaatgg ttaattgtaa 11401 ctgaacccgc aggtcacatg tgttaggttt cacagattct atatattact aactctatac 11461 tcgtaattaa cattagataa gtagattaag aaaaaagcct gaggaagatt aagaaaaact 11521 gcttattggg tctttccgtg ttttagatga agcagttgaa attcttcctc ttgatattaa 11581 atggctacac aacataccca atacccagac gctaggttat catcaccaat tgtattggac 11641 caatgtgacc tagtcactag agcttgcggg ttatattcat catactccct taatccgcaa 11701 ctacgcaact gtaaactccc gaaacatatc taccgtttga aatacgatgt aactgttacc 11761 aagttcttga gtgatgtacc agtggcgaca ttgcccatag atttcatagt cccagttctt 11821 ctcaaggcac tgtcaggcaa tggattctgt cctgttgagc cgcggtgcca acagttctta 11881 gatgaaatca ttaagtacac aatgcaagat gctctcttct tgaaatatta tctcaaaaat 11941 gtgggtgctc aagaagactg tgttgatgaa cactttcaag agaaaatctt atcttcaatt 12001 cagggcaatg aatttttaca tcaaatgttt ttctggtatg atctggctat tttaactcga 12061 aggggtagat taaatcgagg aaactctaga tcaacatggt ttgttcatga tgatttaata 12121 gacatcttag gctatgggga ctatgttttt tggaagatcc caatttcaat gttaccactg 12181 aacacacaag gaatccccca tgctgctatg gactggtatc aggcatcagt attcaaagaa 12241 gcggttcaag ggcatacaca cattgtttct gtttctactg ccgacgtctt gataatgtgc 12301 aaagatttaa ttacatgtcg attcaacaca actctaatct caaaaatagc agagattgag 12361 gatccagttt gttctgatta tcccaatttt aagattgtgt ctatgcttta ccagagcgga 12421 gattacttac tctccatatt agggtctgat gggtataaaa ttattaagtt cctcgaacca 12481 ttgtgcttgg ccaaaattca attatgctca aagtacactg agaggaaggg ccgattctta 12541 acacaaatgc atttagctgt aaatcacacc ctagaagaaa ttacagaaat gcgtgcacta 12601 aagccttcac aggctcaaaa gatccgtgaa ttccatagaa cattgataag gctggagatg 12661 acgccacaac aactttgtga gctattttcc attcaaaaac actgggggca tcctgtgcta 12721 catagtgaaa cagcaatcca aaaagttaaa aaacatgcta cggtgctaaa agcattacgc 12781 cctatagtga ttttcgagac atactgtgtt tttaaatata gtattgccaa acattatttt 12841 gatagtcaag gatcttggta cagtgttact tcagatagga atctaacacc gggtcttaat 12901 tcttatatca aaagaaatca attccctccg ttgccaatga ttaaagaact actatgggaa 12961 ttttaccacc ttgaccaccc tccacttttc tcaaccaaaa ttattagtga cttaagtatt 13021 tttataaaag acagagctac cgcagtagaa aggacatgct gggatgcagt attcgagcct 13081 aatgttctag gatataatcc acctcacaaa tttagtacta aacgtgtacc ggaacaattt 13141 ttagagcaag aaaacttttc tattgagaat gttctttcct acgcacaaaa actcgagtat 13201 ctactaccac aatatcggaa cttttctttc tcattgaaag agaaagagtt gaatgtaggt 13261 agaaccttcg gaaaattgcc ttatccgact cgcaatgttc aaacactttg tgaagctctg 13321 ttagctgatg gtcttgctaa agcatttcct agcaatatga tggtagttac ggaacgtgag 13381 caaaaagaaa gcttattgca tcaagcatca tggcaccaca caagtgatga ttttggtgaa 13441 catgccacag ttagagggag tagctttgta actgatttag agaaatacaa tcttgcattt 13501 agatatgagt ttacagcacc ttttatagaa tattgcaacc gttgctatgg tgttaagaat 13561 gtttttaatt ggatgcatta tacaatccca cagtgttata tgcatgtcag tgattattat 13621 aatccaccac ataacctcac actggagaat cgagacaacc cccccgaagg gcctagttca 13681 tacaggggtc atatgggagg gattgaagga ctgcaacaaa aactctggac aagtatttca 13741 tgtgctcaaa tttctttagt tgaaattaag actggtttta agttacgctc agctgtgatg 13801 ggtgacaatc agtgcattac tgttttatca gtcttcccct tagagactga cgcagacgag 13861 caggaacaga gcgccgaaga caatgcagcg agggtggccg ccagcctagc aaaagttaca 13921 agtgcctgtg gaatcttttt aaaacctgat gaaacatttg tacattcagg ttttatctat 13981 tttggaaaaa aacaatattt gaatggggtc caattgcctc agtcccttaa aacggctaca 14041 agaatggcac cattgtctga tgcaattttt gatgatcttc aagggaccct ggctagtata 14101 ggcactgctt ttgagcgatc catctctgag acacgacata tctttccttg caggataacc 14161 gcagctttcc atacgttttt ttcggtgaga atcttgcaat atcatcatct cgggttcaat 14221 aaaggttttg accttggaca gttaacactc ggcaaacctc tggatttcgg aacaatatca 14281 ttggcactag cggtaccgca ggtgcttgga gggttatcct tcttgaatcc tgagaaatgt 14341 ttctaccgga atctaggaga tccagttacc tcaggcttat tccagttaaa aacttatctc 14401 cgaatgattg agatggatga tttattctta cctttaattg cgaagaaccc tgggaactgc 14461 actgccattg actttgtgct aaatcctagc ggattaaatg tccctgggtc gcaagactta 14521 acttcatttc tgcgccagat tgtacgcagg accatcaccc taagtgcgaa aaacaaactt 14581 attaatacct tatttcatgc gtcagctgac ttcgaagacg aaatggtttg taaatggcta 14641 ttatcatcaa ctcctgttat gagtcgtttt gcggccgata tcttttcacg cacgccgagc 14701 gggaagcgat tgcaaattct aggatacctg gaaggaacac gcacattatt agcctctaag 14761 atcatcaaca ataatacaga gacaccggtt ttggacagac tgaggaaaat aacattgcaa 14821 aggtggagcc tatggtttag ttatcttgat cattgtgata atatcctggc ggaggcttta 14881 acccaaataa cttgcacagt tgatttagca cagattctga gggaatattc atgggctcat 14941 attttagagg gaagacctct tattggagcc acactcccat gtatgattga gcaattcaaa 15001 gtgttttggc tgaaacccta cgaacaatgt ccgcagtgtt caaatgcaaa gcaaccaggt 15061 gggaaaccat tcgtgtcagt ggcagtcaag aaacatattg ttagtgcatg gccgaacgca 15121 tcccgaataa gctggactat cggggatgga atcccataca ttggatcaag gacagaagat 15181 aagataggac aacctgctat taaaccaaaa tgtccttccg cagccttaag agaggccatt 15241 gaattggcgt cccgtttaac atgggtaact caaggcagtt cgaacagtga cttgctaata 15301 aaaccatttt tggaagcacg agtaaattta agtgttcaag aaatacttca aatgacccct 15361 tcacattact caggaaatat tgttcacagg tacaacgatc aatacagtcc tcattctttc 15421 atggccaatc gtatgagtaa ttcagcaacg cgattgattg tttctacaaa cactttaggt 15481 gagttttcag gaggtggcca gtctgcacgc gacagcaata ttattttcca gaatgttata 15541 aattatgcag ttgcactgtt cgatattaaa tttagaaaca ctgaggctac agatatccaa 15601 tataatcgtg ctcaccttca tctaactaag tgttgcaccc gggaagtacc agctcagtat 15661 ttaacataca catctacatt ggatttagat ttaacaagat accgagaaaa cgaattgatt 15721 tatgacagta atcctctaaa aggaggactc aattgcaata tctcattcga taatccattt 15781 ttccaaggta aacggctgaa cattatagaa gatgatctta ttcgactgcc tcacttatct 15841 ggatgggagc tagccaagac catcatgcaa tcaattattt cagatagcaa caattcatct 15901 acagacccaa ttagcagtgg agaaacaaga tcattcacta cccatttctt aacttatccc 15961 aagataggac ttctgtacag ttttggggcc tttgtaagtt attatcttgg caatacaatt 16021 cttcggacta agaaattaac acttgacaat tttttatatt acttaactac tcaaattcat 16081 aatctaccac atcgctcatt gcgaatactt aagccaacat tcaaacatgc aagcgttatg 16141 tcacggttaa tgagtattga tcctcatttt tctatttaca taggcggtgc tgcaggtgac 16201 agaggactct cagatgcggc caggttattt ttgagaacgt ccatttcatc ttttcttaca 16261 tttgtaaaag aatggataat taatcgcgga acaattgtcc ctttatggat agtatatccg 16321 ctagagggtc aaaacccaac acctgtgaat aattttctct atcagatcgt agaactgctg 16381 gtgcatgatt catcaagaca acaggctttt aaaactacca taagtgatca tgtacatcct 16441 cacgacaatc ttgtttacac atgtaagagt acagccagca atttcttcca tgcatcattg 16501 gcgtactgga ggagcagaca cagaaacagc aaccgaaaat acttggcaag agactcttca 16561 actggatcaa gcacaaacaa cagtgatggt catattgaga gaagtcaaga acaaaccacc 16621 agagatccac atgatggcac tgaacggaat ctagtcctac aaatgagcca tgaaataaaa 16681 agaacgacaa ttccacaaga aaacacgcac cagggtccgt cgttccagtc ctttctaagt 16741 gactctgctt gtggtacagc aaatccaaaa ctaaatttcg atcgatcgag acacaatgtg 16801 aaatttcagg atcataactc ggcatccaag agggaaggtc atcaaataat ctcacaccgt 16861 ctagtcctac ctttctttac attatctcaa gggacacgcc aattaacgtc atccaatgag 16921 tcacaaaccc aagacgagat atcaaagtac ttacggcaat tgagatccgt cattgatacc 16981 acagtttatt gtagatttac cggtatagtc tcgtccatgc attacaaact tgatgaggtc 17041 ctttgggaaa tagagagttt caagtcggct gtgacgctag cagagggaga aggtgctggt 17101 gccttactat tgattcagaa ataccaagtt aagaccttat ttttcaacac gctagctact 17161 gagtccagta tagagtcaga aatagtatca ggaatgacta ctcctaggat gcttctacct 17221 gttatgtcaa aattccataa tgaccaaatt gagattattc ttaacaactc agcaagccaa 17281 ataacagaca taacaaatcc tacttggttt aaagaccaaa gagcaaggct acctaagcaa 17341 gtcgaggtta taaccatgga tgcagagaca acagagaata taaacagatc gaaattgtac 17401 gaagctgtat ataaattgat cttacaccat attgatccta gcgtattgaa agcagtggtc 17461 cttaaagtct ttctaagtga tactgagggt atgttatggc taaatgataa tttagccccg 17521 ttttttgcca ctggttattt aattaagcca ataacgtcaa gtgctagatc tagtgagtgg 17581 tatctttgtc tgacgaactt cttatcaact acacgtaaga tgccacacca aaaccatctc 17641 agttgtaaac aggtaatact tacggcattg caactgcaaa ttcaacgaag cccatactgg 17701 ctaagtcatt taactcagta tgctgactgt gagttacatt taagttatat ccgccttggt 17761 tttccatcat tagagaaagt actataccac aggtataacc tcgtcgattc aaaaagaggt 17821 ccactagtct ctatcactca gcacttagca catcttagag cagagattcg agaattaact 17881 aatgattata atcaacagcg acaaagtcgg actcaaacat atcactttat tcgtactgca 17941 aaaggacgaa tcacaaaact agtcaatgat tatttaaaat tctttcttat tgtgcaagca 18001 ttaaaacata atgggacatg gcaagctgag tttaagaaat taccagagtt gattagtgtg 18061 tgcaataggt tctaccatat tagagattgc aattgtgaag aacgtttctt agttcaaacc 18121 ttatatttac atagaatgca ggattctgaa gttaagctta tcgaaaggct gacagggctt 18181 ctgagtttat ttccggatgg tctctacagg tttgattgaa ttaccgtgca tagtatcctg 18241 atacttgcaa aggttggtta ttaacataca gattataaaa aactcataaa ttgctctcat 18301 acatcatatt gatctaatct caataaacaa ctatttaaat aacgaaagga gtccctatat 18361 tatatactat atttagcctc tctccctgcg tgataatcaa aaaattcaca atgcagcatg 18421 tgtgacatat tactgccgca atgaatttaa cgcaacataa taaactctgc actctttata 18481 attaagcttt aacgaaaggt ctgggctcat attgttattg atataataat gttgtatcaa 18541 tatcctgtca gatggaatag tgttttggtt gataacacaa cttcttaaaa caaaattgat 18601 ctttaagatt aagtttttta taattatcat tactttaatt tgtcgtttta aaaacggtga 18661 tagccttaat ctttgtgtaa aataagagat taggtgtaat aaccttaaca tttttgtcta 18721 gtaagctact atttcataca gaatgataaa attaaaagaa aaggcaggac tgtaaaatca 18781 gaaatacctt ctttacaata tagcagacta gataataatc ttcgtgttaa tgataattaa 18841 gacattgacc acgctcatca gaaggctcgc cagaataaac gttgcaaaaa ggattcctgg 18901 aaaaatggtc gcacacaaaa atttaaaaat aaatctattt cttctttttt gtgtgtcca //